@base <http://www.agfa.com/w3c/2009/malignantNeoplasm#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix event: <http://eulersharp.sourceforge.net/2003/03swap/event#> .
@prefix quant: <http://eulersharp.sourceforge.net/2003/03swap/quantities#> .
@prefix clisko: <clinicalSKOSSchemes#> .
@prefix humdis: <humanDisorder#> .
@prefix clinmorph: <clinicalMorphology#> .
@prefix ther: <therapy#> .
@prefix malneo: <> .

<>
    dce:contributor "Julia von Tresckow, MD, University Clinic of Cologne; Susanne Hagist, MD, University Clinic of Cologne" ;
    dce:creator "Hans Cools, MD, Agfa Healthcare/Belgium"@en ;
    dce:description "Formal description of human malignant neoplasia."@en ;
    dce:format "OWL Full"@en ;
    dce:publisher "Agfa Healthcare/Belgium"@en ;
    dce:source "http://nciterms.nci.nih.gov/ncitbrowser/pages/multiple_search.jsf (NCI)"@en ;
    dce:title "Malignant Neoplasia"@en ;
    a owl:Ontology ;
    rdfs:comment "Copyright (c) 2009 Agfa-Gevaert Group All Rights Reserved. THIS IS UNPUBLISHED PROPRIETARY SOURCE CODE OF Agfa-Gevaert Group The copyright notice above does not evidence any actual or intended publication of such source code."@en .

malneo:Anaplastic
    a malneo:Malignant, rdfs:Class ;
    rdfs:isDefinedBy <> ;
    rdfs:label "anaplastic"@en ;
    skos:definition "State of a human cell dividing rapidly and having little or no resemblance to a normal cell (NCI)."@en .

malneo:LymphoidHaematopoieticMalignantNeoplasia
    a rdfs:Class ;
    rdfs:isDefinedBy <> ;
    rdfs:label "malignant neoplasia of lymphoid, haematopoietic and related tissue"@en ;
    rdfs:subClassOf malneo:MalignantNeoplasia ;
    skos:definition "Malignant neoplasia of lymphoid, haematopoetic and related tissue, so called leukemia and lymphoma."@en .

malneo:LymphoidHaematopoieticMalignantNeoplasm
    a rdfs:Class ;
    rdfs:isDefinedBy <> ;
    rdfs:label "malignant neoplasm of lymphoid, haematopoietic and related tissue"@en ;
    rdfs:subClassOf malneo:MalignantNeoplasm ;
    skos:definition "Malignant neoplasm as a result of malignant neoplasia of lymphoid, haematopoetic and related tissue."@en .

malneo:Malignant
    a rdfs:Class ;
    rdfs:isDefinedBy <> ;
    rdfs:label "malignant"@en ;
    rdfs:subClassOf humdis:Malignant ;
    skos:definition "State of having anaplastic cells, with or without being invasive and/or metastatic and/or clonal."@en .

malneo:MalignantNeoplasia
    a rdfs:Class ;
    rdfs:isDefinedBy <> ;
    rdfs:label "malignant neoplasia"@en ;
    rdfs:subClassOf humdis:Neoplasia, [
        a owl:Restriction ;
        owl:onProperty event:hasOutput ;
        owl:someValuesFrom malneo:MalignantNeoplasm
    ], [
        a owl:Restriction ;
        owl:onProperty humdis:hasState ;
        owl:someValuesFrom malneo:Malignant
    ] ;
    skos:definition "Malignant cell proliferation."@en .

malneo:MalignantNeoplasm
    a rdfs:Class ;
    rdfs:isDefinedBy <> ;
    rdfs:label "malignant neoplasm"@en ;
    rdfs:subClassOf clinmorph:Neoplasm, [
        a owl:Restriction ;
        owl:onProperty event:outputOf ;
        owl:someValuesFrom malneo:MalignantNeoplasia
    ] ;
    skos:definition "Abnormal tissue as a result of malignant neoplasia."@en .

malneo:Melanoma
    a rdfs:Class ;
    rdfs:isDefinedBy <> ;
    rdfs:label "melanoma"@en ;
    rdfs:subClassOf malneo:MalignantNeoplasia ;
    skos:definition "Malignant neoplasia of melanocytes of skin."@en .

malneo:MinimalResidual
    a malneo:Anaplastic, rdfs:Class ;
    rdfs:isDefinedBy <> ;
    rdfs:label "minimal residual"@en ;
    rdfs:subClassOf ther:Residual ;
    skos:definition "State of a malignant neoplasia having a small number of anaplastic cells remaining after treatment when the patient is in remission."@en .

malneo:MinimalResidualDisease
    a rdfs:Class ;
    rdfs:isDefinedBy <> ;
    rdfs:label "minimal residual disease"@en ;
    rdfs:subClassOf malneo:MalignantNeoplasia, [
        a owl:Restriction ;
        owl:onProperty humdis:hasState ;
        owl:someValuesFrom malneo:MinimalResidual
    ] ;
    skos:definition "Small number of anaplastic cells remaining in a patient (during or) after treatment when the patient is in remission."@en .

malneo:SecondaryBrainAndMeningesMalignantNeoplasia
    a rdfs:Class ;
    rdfs:isDefinedBy <> ;
    rdfs:label "secondary brain and cerebral meninges malignant neoplasia"@en ;
    rdfs:subClassOf malneo:MalignantNeoplasia, [
        a owl:Restriction ;
        owl:onProperty humdis:hasState ;
        owl:someValuesFrom humdis:Secondary
    ] ;
    skos:definition "Brain and cerebral meninges malignant neoplasia due to another human health disorder."@en ;
    skos:exactMatch [
        a skos:Concept ;
        skos:inScheme clisko:icd10 ;
        skos:notation "C79.3"^^clisko:icd10DT
    ] .

malneo:SecondaryColonAndRectumMalignantNeoplasia
    a rdfs:Class ;
    rdfs:isDefinedBy <> ;
    rdfs:label "secondary colon and rectum malignant neoplasia"@en ;
    rdfs:subClassOf malneo:MalignantNeoplasia, [
        a owl:Restriction ;
        owl:onProperty humdis:hasState ;
        owl:someValuesFrom humdis:Secondary
    ] ;
    skos:definition "Colon and rectum malignant neoplasia due to another human health disorder."@en ;
    skos:exactMatch [
        a skos:Concept ;
        skos:inScheme clisko:sct20080731 ;
        skos:notation "188444005"^^clisko:sct20080731DT
    ], [
        a skos:Concept ;
        skos:inScheme clisko:icd10 ;
        skos:notation "C78.5"^^clisko:icd10DT
    ] .

malneo:SecondarySkinMalignantNeoplasia
    a rdfs:Class ;
    rdfs:isDefinedBy <> ;
    rdfs:label "secondary skin malignant neoplasia"@en ;
    rdfs:subClassOf malneo:MalignantNeoplasia, [
        a owl:Restriction ;
        owl:onProperty humdis:hasState ;
        owl:someValuesFrom humdis:Secondary
    ] ;
    skos:definition "Skin malignant neoplasia due to another human health disorder."@en ;
    skos:exactMatch [
        a skos:Concept ;
        skos:inScheme clisko:sct20080731 ;
        skos:notation "94579000"^^clisko:sct20080731DT
    ], [
        a skos:Concept ;
        skos:inScheme clisko:icd10 ;
        skos:notation "C79.2"^^clisko:icd10DT
    ] .

malneo:TrunkMelanoma
    a rdfs:Class ;
    rdfs:isDefinedBy <> ;
    rdfs:label "melanoma of trunk"@en ;
    rdfs:subClassOf malneo:Melanoma ;
    skos:definition "Malignant neoplasia of melanocytes of skin of trunk."@en ;
    skos:exactMatch [
        a skos:Concept ;
        skos:inScheme clisko:sct20080731 ;
        skos:notation "269579005"^^clisko:sct20080731DT
    ], [
        a skos:Concept ;
        skos:inScheme clisko:icd10 ;
        skos:notation "C43.5"^^clisko:icd10DT
    ] .