chear
type: Ontology
comment: Children's health and wellbeing are influenced by interactions between environmental and genetic factors. NIEHS is establishing an infrastructure, the Children's Health Exposure Analysis Resource (CHEAR), to provide the extramural research community access to laboratory and data analyses that add or expand the inclusion of environmental exposures in children's health research. The goal of CHEAR is to provide tools so researchers can assess the full range of environmental exposures which may affect children's health. We anticipate that CHEAR will be used by children's health researchers conducting epidemiological or clinical studies that currently have limited consideration of environmental exposures, or those who have collected exposure data but seek more extensive analyses. Read more at: https://www.niehs.nih.gov/research/supported/exposure/chear/
imports: cogat
imports: hasco
imports: cl-basic.owl
imports: cmo.owl
imports: stato.owl
imports: uo.owl
imports: sio-subset-labels.owl
version IRI: http://hadatac.org/ont/chear/2.8

PCB153
type: Class
subclass of: Polychlorobiphenyl
notation: PCB153

N-Acetyl-S-(2-carbamoylethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: AAMA

Mercapturic acids of acrolein and crotonaldehyde
type: Class
subclass of: PAH
notation: AMA

N-Acetyl-S-(N-methylcarbamoyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: AMCC

Apgar Score
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Datatype
    intersection of: Datatype
      on datatype: integer
      with restrictions:
        min inclusive: 0
    intersection of: Datatype
      on datatype: integer
      with restrictions:
        max inclusive: 10
  on property: hasValue
subclass of: Birth Outcome
subclass of: Sum
definition: A method to quickly summarize the health of newborn children. The Apgar score was invented by Virginia Apgar in 1952 when Apgar was an anesthesiologist who developed the score in order to ascertain the effects of obstetric anesthesia on babies. The Apgar scale is determined by evaluating the newborn baby on five simple criteria on a scale from zero to two, then summing up the five values thus obtained. The resulting Apgar score ranges from zero to 10. The five criteria are summarized using words chosen to form a backronym (Appearance, Pulse, Grimace, Activity, Respiration).

2-Aminothiazoline-4-carboxylic acid
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: ATCA

Absorbance Reader
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Microplate Reader
definition: Absorbance readers are used for assays such as ELISA assays, protein and nucleic acid quantification or enzyme activity assays. A light source illuminates the sample using a specific wavelength (selected by an optical filter, or a monochromator), and a light detector located on the other side of the well measures how much of the initial (100%) light is transmitted through the sample: the amount of transmitted light will typically be related to the concentration of the molecule of interest.

Active Non-Tobacco Smoker
type: QualityValue
type: Class
subclass of: Active Smoker
definition: Active Non-Tobacco Smoker
notation: 1

Adolescent Period
type: Class
subclass of: Restriction
  all values from: Class
    intersection of: Birthing
  on property: inRelationTo
subclass of: FromBirth
subclass of: TimeInterval
definition: The age span ranging from adolescence to adulthood

Adopted
type: Class
subclass of: Non-Biological Relative
definition: Adoption is a process whereby a person assumes the parenting of another, usually a child, from that person's biological or legal parent or parents, and, in so doing, permanently transfers all rights and responsibilities, along with filiation, from the biological parent or parents.

Adult
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Demographic
subclass of: Developmental Quality
definition: Refers to a person above a threshold age.
notation: 3

Advanced Graduate Degree
type: QualityValue
type: Class
subclass of: Education
definition: Having earned a pos-baccalaureate degree
notation: 4

Agilent 1100 HPLC
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: High-Performance Liquid Chromatography

Aligent 8800 Triple Quadrupole ICP-MS
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Triple Quadrupole Inductively Coupled Plasma Mass Spectrometer

Analysis Mode
type: QualityVariable
type: Class
subclass of: SampleIndicator
definition: Analysis Mode

Atomic Absorption Spectroscopy
type: Class
subclass of: Atomic Spectroscopy

Atomic Emission Spectroscopy
type: Class
subclass of: Atomic Spectroscopy

1-hydroxybenz[a]anthacene
type: Class
subclass of: PAH
editorial note: Only found in one journal article, no where else. Maybe mis-spelled?
notation: BAA1

Benzo[a]pyrene tetraol
type: Class
subclass of: PAH
notation: BAPT

1-hydroxybenzo[c]-phenanthrene
type: Class
subclass of: PAH
notation: BCP1

2-hydroxybenzo[c]-phenanthrene
type: Class
subclass of: PAH
notation: BCP2

3-hydroxybenzo[c]-phenanthrene
type: Class
subclass of: PAH
notation: BCP3

2,2',4,4',6-Pentabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
editorial note: To Do: align with CHEBI.
notation: BDE100

2,2',4,4',5,5'-Hexabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
editorial note: To Do: align with CHEBI.
notation: BDE153

2,2',4,4',5,6'-Hexabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
editorial note: To Do: align with CHEBI.
notation: BDE154

2,2',4'-Tribromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
editorial note: To Do: align with CHEBI.
notation: BDE17

2,2',3,4,4',5',6-Heptabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
editorial note: To Do: align with CHEBI.
notation: BDE183

2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
editorial note: To Do: align with CHEBI.
notation: BDE209

2,4,4'-Tribromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
editorial note: To Do: align with CHEBI.
notation: BDE28

2,2',4,4'-Tetrabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
editorial note: To Do: align with CHEBI.
notation: BDE47

2,3',4,4'-Tetrabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
editorial note: To Do: align with CHEBI.
notation: BDE66

2,2',3,4,4'-Pentabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
editorial note: To Do: align with CHEBI.
notation: BDE85

2,2',4,4',5-Pentabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
editorial note: To Do: align with CHEBI.
notation: BDE99

Blackbody Infrared Radiative Dissociation (BIRD)
type: Class
subclass of: TandemMassSpectrometry

N-Acetyl-S-(benzyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: BMA

Benzophenone-3
type: Class
subclass of: Environmental Phenol
definition: Oxybenzone is a benzophenone derivative used as a sunscreen agent. Oxybenzone absorbs UVB and UVA II rays, resulting in a photochemical excitation and absorption of energy. Upon return to ground state, the absorbed energy results in emission of longer wavelength radiation and decreased skin penetration of radiation which reduces the risk of DNA damage.
editorial note: Duplicate of OXB?
notation: BP3

N-Acetyl-S-(n-propyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: BPMA

Behavior Rating Inventory of Executive Function – Preschool Version
type: Class
subclass of: NeurocognitiveAssessent
definition: Standardized rating scale designed to specifically measure the range of executive function in preschool-aged children

Bathroom Count
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Room Count
definition: Total Number of Bathrooms in the Home

Bedroom Count
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Room Count
definition: Total Number of Bedrooms in the Home

Before
type: Class
subclass of: RelativeTime
definition: A negative index of a time measurement in relation to a reference event. A conventional time measurement can be generated from a before time measurement by duplicating the measurement, reversing the sign of the value, and removing the "Before" class.

Biological Relative
type: Class
subclass of: Relative
definition: Being from the same biological kinship as another person. In that aspect, consanguinity is the quality of being descended from the same ancestor as another person.

Birth Cohort Study
type: Class
subclass of: CohortStudy

Bisulfite Pyrosequencing
type: Class
subclass of: Nucleic Acid Sequencing

Boiler Count
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Household Appliance Count
definition: A boiler is an object that heats up water. This attribute quantifies the number of boilers in the home.

Buccal Cell
type: Class
subclass of: Cell
definition: Cells collected from the inner epithelium of the cheek

Preschool Child Behavior Checklist
type: Class
subclass of: NeurocognitiveAssessent
definition: Child Behavior Checklist for ages 1 ½ through 5

Preschool Child Behavior Checklist Externalizing Subscale
type: Class
subclass of: NeurocognitiveAssessent
definition: Subscale of preschool CBCL that assesses externalizing behaviors

Preschool Child Behavior Checklist Internalizing Subscale
type: Class
subclass of: NeurocognitiveAssessent
definition: Subscale of preschool CBCL that assesses internalizing behaviors

N-Acetyl-S- (2-carboxyethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: CEMA

3-hydroxychrysene
type: Class
subclass of: PAH
notation: CHRY3

Collision-Induced Dissociation (CID)
type: Class
subclass of: TandemMassSpectrometry

Cotinine (total)
type: Class
subclass of: Tobacco Metabolite
editorial note: To Do: align with CHEBI.
notation: COTT

Cold Vapor Atomic Fluorescence Spectroscopy Instrument
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Atomic Fluorescence Spectroscopy Instrument
definition: Used in the measurement of trace amounts of volatile heavy metals such as mercury, cold vapour AFS makes use of the unique characteristic of mercury that allows vapour measurement at room temperature.

N-Acetyl-S-(2-cyanoethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: CYMA

Canned Food Consumption
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Canned Food Consumption Frequency
definition: Whether or not canned food is consumed.
notation: 9

Car Count
type: QuantityVariable
type: Class
subclass of: Housing Characteristic
subclass of: Count
definition: Total Number of Cars in the Home
editorial note: Again, this isn't related to physical properties of housing. This is more closely related to Socioeconomic Status. Consider moving it.

Cement Floor
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Floor Type
definition: Cement Floor Type
notation: 10

Childhood Cohort Study
type: Class
subclass of: CohortStudy

Childhood Period
type: Class
subclass of: Restriction
  all values from: Class
    intersection of: Birthing
  on property: inRelationTo
subclass of: FromBirth
subclass of: TimeInterval
definition: The age span ranging from birth to adolescence

Fibrinogen Assay (Clauss method)
type: Class
subclass of: Assay

Collection Date of Sample
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: TimeInterval
definition: Collection Date of Sample

College Graduate
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: C0424933
definition: The quality of having graduated from College
notation: 12

Color Object Association Test
type: Class
subclass of: NeurocognitiveAssessent
definition: a reliable and a valid measure of declarative memory for healthy children ages 18-36 months, living in a disadvantaged community

Colorimetric Assay
type: Class
subclass of: Assay

Valid measurement
type: Class
subclass of: Comment

Slightly hemolyzed
type: Class
subclass of: Comment

Moderately hemolyzed
type: Class
subclass of: Comment

Markedly hemolyzed
type: Class
subclass of: Comment

Icteric
type: Class
subclass of: Comment

Turbid
type: Class
subclass of: Comment

Very turbid
type: Class
subclass of: Comment

Lipemic
type: Class
subclass of: Comment

Lipemic sample, clarified before running
type: Class
subclass of: Comment

Cellular debris present
type: Class
subclass of: Comment

Small clot present
type: Class
subclass of: Comment

Run out-of-contol; insufficient sample for repeat analysis
type: Class
subclass of: Comment

Fibrin present
type: Class
subclass of: Comment

Red blood cells present
type: Class
subclass of: Comment

Interfering substances present
type: Class
subclass of: Comment

Urine grossly hematuric
type: Class
subclass of: Comment

Quantity of sample insufficient for analysis
type: Class
subclass of: Comment

Quantity of sample insufficient for repeat analysis
type: Class
subclass of: Comment

Sample integrity/quality compromised preventing analysis
type: Class
subclass of: Comment

Sample older than 2 weeks
type: Class
subclass of: Comment

Cyclomicrons present
type: Class
subclass of: Comment

Dilution required
type: Class
subclass of: Comment

Result repeated and confirmed
type: Class
subclass of: Comment

Unusually high
type: Class
subclass of: Comment

Unusual color
type: Class
subclass of: Comment

Value less than LOD
type: Class
subclass of: Comment

Analyzed at a later date than rest of samples on worksheet (not a repeat)
type: Class
subclass of: Comment

Short sample; sample probe picked up incomplete volume first time
type: Class
subclass of: Comment

Thawed and clotted
type: Class
subclass of: Comment

Thawed and hemolyzed (covers all three levels)
type: Class
subclass of: Comment

Thawed, hemolyzed (covers all three levels) and exposed to light
type: Class
subclass of: Comment

Hemolyzed (covers all three levels), lipemic, and icteric
type: Class
subclass of: Comment

Hemolyzed (covers all three levels) and contaminated
type: Class
subclass of: Comment

Hemolyzed (covers all three levels) and debris present
type: Class
subclass of: Comment

Hemolyzed (covers all three levels) and lipemic
type: Class
subclass of: Comment

Lab confirmed result
type: Class
subclass of: Comment

Did not precipitate
type: Class
subclass of: Comment

Lipemic and turbid
type: Class
subclass of: Comment

Sample frozen
type: Class
subclass of: Comment

No Hct, Hct=40 assumed
type: Class
subclass of: Comment

Panel change
type: Class
subclass of: Comment

Failed negative control
type: Class
subclass of: Comment

Failed positive control
type: Class
subclass of: Comment

Partial match
type: Class
subclass of: Comment

Greater than 99th percentile
type: Class
subclass of: Comment

Mitest not capped
type: Class
subclass of: Comment

Torn, perforated screen
type: Class
subclass of: Comment

Broken Mitest
type: Class
subclass of: Comment

Torn bag (Mitest intact, capped)
type: Class
subclass of: Comment

Overloaded filter
type: Class
subclass of: Comment

Abnormal hemoglobin variant observed
type: Class
subclass of: Comment

Obvious coarse debris
type: Class
subclass of: Comment

Predominantly fibrous material
type: Class
subclass of: Comment

Initial concentration higher than the highest standard
type: Class
subclass of: Comment

Specimen analyzed with less than normal quantity
type: Class
subclass of: Comment

Specimen analyzed in singlicate for an assay that requires duplicates
type: Class
subclass of: Comment

No FOL result; FOL = 8 ng/mL assumed
type: Class
subclass of: Comment

Result repeated with diluted sample
type: Class
subclass of: Comment

Detectable
type: Class
subclass of: Comment

Result reported based on fewer replicates than required
type: Class
subclass of: Comment

Specimen analyzed with less than usual dilution
type: Class
subclass of: Comment

Samples Arrived Thawed and Analyzed
type: Class
subclass of: Comment

HUC sample having discrepancy between fluorometer results and semi quantative Albustix test results
type: Class
subclass of: Comment

No preservative added
type: Class
subclass of: Comment

Common Era
type: Class
subclass of: RelativeTime
equivalent class: Restriction
  has value: First Year of the Common Era
  on property: inRelationTo
definition: Common era time measurements are referenced against (in relation to) the beginning of the common era, 1 CE (or 1 AD).

Competitive-inhibition enzyme-linked immunosorbent assay
type: Class
subclass of: enzyme-linked immunosorbent assay (ELISA)

Competitive Immunoassay
type: Class
subclass of: Immunoassay

Computer
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Household Appliance Count
definition: A machine used for computation and much more.

Conception
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Class
    intersection of: Conceiving
  on property: inRelationTo
subclass of: Beginning
subclass of: FromConception
subclass of: TimeInterval
definition: When a sperm fertilizes an egg

Consumed Alcohol
type: QualityValue
type: Class
subclass of: Alcohol Use
notation: 52

Cousin
type: Class
subclass of: Relative
definition: A person belonging to the same extended family.

N-Acetyl-S-(1,2-dichlorovinyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: DCVMA12

N-Acetyl-S-(2,2-dichlorovinyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: DCVMA22

diethyldithiophosphate
type: Class
subclass of: Alkyl Phosphate Pesticide Metabolite
editorial note: To Do: align with CHEBI.
notation: DEDP

diethylphosphate
type: Class
subclass of: Alkyl Phosphate Pesticide Metabolite
editorial note: To Do: align with CHEBI.
notation: DEP

diethylthiophosphate
type: Class
subclass of: Alkyl Phosphate Pesticide Metabolite
editorial note: To Do: align with CHEBI.
notation: DETP

N-Acetyl-S- (3,4-dihydroxybutyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: DHBMA

dimethyldithiophosphate
type: Class
subclass of: Alkyl Phosphate Pesticide Metabolite
editorial note: To Do: align with CHEBI.
notation: DMDP

dimethylphosphate
type: Class
subclass of: Alkyl Phosphate Pesticide Metabolite
editorial note: To Do: align with CHEBI.
notation: DMP

dimethylthiophosphate
type: Class
subclass of: Alkyl Phosphate Pesticide Metabolite
editorial note: To Do: align with CHEBI.
notation: DMTP

N-Acetyl-S-(2,4-dimethylphenyl)-L-cysteine + N-Acetyl-S-(2,5-dimethylphenyl)-L-cysteine + N-Acetyl-S-(3,4-dimethylphenyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: DPMA

DVD Player Count
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Household Appliance Count
definition: Number of devices in the home that play DVDs.

Date of Birth
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Demographic
subclass of: TimeInterval
definition: Date of day on which a person was born.

Daughter
type: Class
subclass of: Restriction
  all values from: Restriction
    on property: hasAttribute
    some values from: Female
  on property: isRoleOf
subclass of: Child
definition: The female offspring in relation to her parents.

Dental Fillings
type: QualityValue
type: Class
subclass of: Oral Health
notation: 13

Did Not Consume Alcohol
type: QualityValue
type: Class
subclass of: Alcohol Use
notation: 53

Diet Treatment Medical Therapy
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Medical Therapy Procedure
definition: Diet Treatment is a form of Medical Therapy.
notation: 26

Difference
type: Class
subclass of: Quantity
definition: Variables derived from taking the difference of two other variables. For example, the first difference of a time series {yt} is defined as Dyt = yt - yt-1

Drug History
type: QualityVariable
type: Class
subclass of: Alcohol, Tobacco, and Illicit Drug Use
notation: 14

Electron Capture Dissociation (ECD)
type: Class
subclass of: TandemMassSpectrometry

Electron-Detachment Dissociation (EDD)
type: Class
subclass of: TandemMassSpectrometry

Enzyme Immunoassay
type: Class
subclass of: Immunoassay

Electron Transfer Dissociation (ETD)
type: Class
subclass of: TandemMassSpectrometry

Early Childhood Vigilance Test
type: Class
subclass of: NeurocognitiveAssessent
definition: a computer-based assessment of sustained attention during which the child is required to watch a screen where various animated stimuli disappear and reappear

Education Grade 1
type: QualityValue
type: Class
subclass of: Some Elementary School
definition: Finished grade 1
notation: 113

Education Grade 2
type: QualityValue
type: Class
subclass of: Some Elementary School
definition: Finished grade 2
notation: 114

Education Grade 3
type: QualityValue
type: Class
subclass of: Some Elementary School
definition: Finished grade 3
notation: 115

Education Grade 4
type: QualityValue
type: Class
subclass of: Elementary School
definition: Finished grade 4
notation: 116

Education Grade 5
type: QualityValue
type: Class
subclass of: Some Middle School
definition: Finished grade 5
notation: 117

Education Grade 6
type: QualityValue
type: Class
subclass of: Some Middle School
definition: Finished grade 6
notation: 118

Education Grade 7
type: QualityValue
type: Class
subclass of: Some Middle School
definition: Finished grade 7
notation: 119

Elective Caesarian Section
type: QualityValue
type: Class
subclass of: Caesarian Section
definition: A caesarian section that was chosen by the mother but was not medically necessary.
notation: 19

active eosinophilic esophagitis
type: Class
comment: Eosinophilic esophagitis is active when a biopsy of the esophagus reveals a count of more than 25 eosinophils per high-power field area, or 0.158 mm^2 (400x).
subclass of: eosinophilic esophagitis
equivalent class: Restriction
  all values from: Class
    intersection of: Esophagus
    intersection of: Restriction
      on property: hasAttribute
      some values from: Class
        intersection of: eosinophils per high-power field
        intersection of: Restriction
  on property: isPhenotypeOf

mild eosinophilic esophagitis
type: Class
comment: Eosinophilic esophagitis is mild when a biopsy of the esophagus reveals a count of 15-25 eosinophils per high-power field area, or 0.158 mm^2 (400x).
subclass of: eosinophilic esophagitis
equivalent class: Restriction
  all values from: Class
    intersection of: Esophagus
    intersection of: Restriction
      on property: hasAttribute
      some values from: Class
        intersection of: eosinophils per high-power field
        intersection of: Restriction
  on property: isPhenotypeOf

eosinophilic esophagitis in remission
type: Class
comment: Eosinophilic esophagitis is active when a biopsy of the esophagus reveals a count of less than 15 eosinophils per high-power field area, or 0.158 mm^2 (400x).
subclass of: eosinophilic esophagitis
equivalent class: Restriction
  all values from: Class
    intersection of: Esophagus
    intersection of: Restriction
      on property: hasAttribute
      some values from: Class
        intersection of: eosinophils per high-power field
        intersection of: Restriction
  on property: isPhenotypeOf

Ever Smoked
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Smoking Status
definition: The quality of having smoking in the past.
notation: 136

Fast Food Consumption
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Fast Food Consumption Frequency
definition: Whether or not fast food is consumed.
notation: 16

Father
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Restriction
    on property: hasAttribute
    some values from: Male
  on property: isRoleOf
subclass of: Parent
definition: The male parent of a child. Besides the paternal bonds of a father to his children, the father may have a parental legal and social relationship with the child that carries with it certain rights and obligations. An adoptive father is a male who has become the child's parent through the legal process of adoption. A biological father is the male genetic contributor to the creation of the baby, through sexual intercourse or sperm donation. A biological father may have legal obligations to a child not raised by him, such as an obligation of monetary support. A putative father is a man whose biological relationship to a child is alleged but has not been established. A stepfather is a male who is the husband of a child's mother and they may form a family unit, but who generally does not have the legal rights and responsibilities of a parent in relation to the child.

First Trimester
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Class
    intersection of: Conceiving
  on property: inRelationTo
subclass of: FromConception
subclass of: TimeInterval
definition: From pregnancy week 1 through 12 and includes conception. Conception is when the sperm fertilizes the egg. The fertilized egg then travels down the fallopian tube and attaches to the inside of the uterus, where it begins to form the embryo and placenta. The first trimester carries the highest risk of miscarriage (natural death of embryo or fetus).

Forceps-Assisted Birth
type: QualityValue
type: Class
subclass of: Vaginal Birth
definition: A vaginal birth with the assistance of forceps to extract the baby.
notation: 25

Foster
type: Class
subclass of: Non-Biological Relative
definition: Fosterage, the practice of a family bringing up a child not their own, differs from adoption in that the child's parents, not the foster-parents, remain the acknowledged parents. In many modern western societies foster care can be organized by the state to care for children with troubled family backgrounds, usually on a temporary basis. In many pre-modern societies fosterage was a form of patronage, whereby influential families cemented political relationships by bringing up each other's children, similar to arranged marriages, also based on dynastic or alliance calculations.

Freeze/Thaw Cycles Count
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Count
definition: Number of Freeze/Thaw cycles.

Fresh Vegetable Consumption
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Fresh Vegetable Consumption Frequency
definition: Whether or not Fresh Vegetables are consumed.
notation: 29

N-Acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: GAMA

Gas Chromatography
type: Class
subclass of: Chromatography

Gas Chromatographer-Tandem Mass Spectrometer
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Gas Chromatographer–Mass Spectrometer
subclass of: Tandem Mass Spectrometer
definition: MS/MS is the combination of two mass analyzers in one mass spec instrument.

Gel Electrophoresis
type: Class
subclass of: Assay
definition: Gel electrophoresis is a method for separation and analysis of macromolecules (DNA, RNA and proteins) and their fragments, based on their size and charge.

Gravida
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Pregnancy Characteristic
subclass of: Count
definition: Pregnancy Count, regardless of whether pregnancy was carried to Term.

Gravimetric Analysis Instrument
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: PhysicalInstrument
definition: Gravimetric analysis describes a set of methods used in analytical chemistry for the quantitative determination of an analyte (the ion being analyzed) based on its mass. The principle behind this type of analysis is that once an ion's mass has been determined as a unique compound, that known measurement can then be used to determine the same analyte's mass in a mixture, as long as the relative quantities of the other constituents are known.

Mercapturic acids of 1,3-butadiene
type: Class
subclass of: Tobacco Metabolite
notation: HEMA

Health Maintenance Organization Insurance
type: QualityValue
type: Class
subclass of: Insurance
notation: 49

High Performance Liquid Chromatography
type: Class
subclass of: Chromatography

HPLC with Fluorescence Level Detector
type: Class
subclass of: High-Performance Liquid Chromatography
definition: HPLC paired with a Fluorescence Level Detector. Fluorescence spectroscopy (also known as fluorometry or spectrofluorometry) is a type of electromagnetic spectroscopy that analyzes fluorescence from a sample. It involves using a beam of light, usually ultraviolet light, that excites the electrons in molecules of certain compounds and causes them to emit light; typically, but not necessarily, visible light. A complementary technique is absorption spectroscopy. In the special case of single molecule fluorescence spectroscopy, intensity fluctuations from the emitted light are measured from either single fluorophores, or pairs of fluorophores.

High Performance Liquid Chromatography - Tandem Mass Spectrometer
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: High-Performance Liquid Chromatography-Mass Spectrometry
subclass of: Liquid Chromatography - Tandem Mass Spectrometer
definition: Liquid chromatography and tandem Mass Spectrometry. MS/MS (Tandem MS) is the combination of two mass analyzers in one mass spec instrument.

N-Acetyl-S- (3-hydroxypropyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: HPMA

N-Acetyl-S-(2-hydroxypropyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: HPMA2

N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: HPMMA

Haircare Product Use
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Personal Product Use
notation: 30

Head Of Household
type: Class
label: Head of Household
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Class
    intersection of: Household
  on property: inRelationTo
subclass of: Demographic
subclass of: Role
definition: Head of Household is a filing status for individual United States taxpayers. To use the Head of Household filing status, a taxpayer must: (1) Be unmarried or considered unmarried at the end of the year (2) Have paid more than half the cost of keeping up a home for the tax year (either one's own home or the home of a qualifying parent) (3) Usually have a qualifying person who lived with the head in the home for more than half of the tax year unless the qualifying person is a dependent parent.
definition: The Person is the head of Household

Graduated From High School
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: High School or Less
definition: The quality of having graduated from High School
notation: 32

Higher Education
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Education
definition: College or university education beyond the successful completion of high school or grammar school, or the attainment of an approved equivalent
notation: 31

Hospital Readmissions
type: Class
subclass of: Hospital Utilization
subclass of: Count
definition: An episode when a patient who had been discharged from a hospital is admitted again within a specified time interval.

Inductively Coupled Plasma Mass Spectrometry
type: Class
subclass of: MassSpectrometry

Intelligence Quotient
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Physical and Mental Assessment
subclass of: Quantity
definition: A measure of intelligence

Infrared Multiphoton Dissociation (IRMPD)
type: Class
subclass of: TandemMassSpectrometry

In Vitro Fertilization
type: QualityValue
type: Class
subclass of: Assisted Reproductive Therapy
notation: 50

Infinium Methylation EPIC BeadChip Assay
type: Class
subclass of: Methylation Assay
subclass of: Microarray Assay

Insurance Type
type: QualityVariable
type: Class
subclass of: Insurance
definition: Insurance Type

SYNAPT G2-Si Mass Spectrometer
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Hydrogen–Deuterium Exchange Mass Spectrometer

Kaufman ABC Sequence Subscale
type: Class
subclass of: NeurocognitiveAssessent
definition: Subscale of Kaufman ABC designed to measure the ability to solve problems by remembering and using an ordered series of images or ideas

Kaufman ABC
type: Class
subclass of: NeurocognitiveAssessent
definition: culturally fair, cognitive ability test for children

Known Food Allergies
type: QualityVariable
type: Class
subclass of: Medical History

Liquid Chromotography -tandem mass spectrometry
type: Class
subclass of: MassSpectrometry

Liquid Chromotography-Multistage Mass Spectrometery
type: Class
subclass of: MassSpectrometry

Landfill Proximity
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Environmental Exposure
subclass of: Length
definition: How close a household is to a landfill.

Light Bulb Count
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Housing Characteristic
subclass of: Count
definition: Total Number of Lightbulbs in the Home

Limit of Detection
type: Class
subclass of: Concentration
definition: The lowest quantity of a substance that can be distinguished from the absence of that substance (a blank value) with a stated confidence level (generally 99%). The detection limit is estimated from the mean of the blank, the standard deviation of the blank and some confidence factor. Another consideration that affects the detection limit is the accuracy of the model used to predict concentration from the raw analytical signal.

Long Range Polymerase Chain Reaction
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Polymerase Chain Reaction
definition: Amplification of DNA lengths that cannot typically be amplified using routine PCR methods or reagents. For simple DNA templates, polymerases optimized for Long Range PCR can amplify up to 30 kb and beyond. For complex, genomic templates, 20 kb is a typical target.

Mandelic acid
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: MA

Cyclohexane-1,2-dicarboxylic acid mono carboxyisooctyl ester (DINCH)
notation: MCOCH

mono (6-COOH-2-methylheptyl) phthalate
type: Class
subclass of: Phthalate
notation: MCOMHP

mono (7-COOH-2-methyloctyl) phthalate
type: Class
subclass of: Phthalate
notation: MCOMOP

mono-2-ethyl-5- carboxypentyl terephthalate (DEHTP)
notation: MECPTP

mono-2-ethyl-5-hydroxyhexyl terephthalate (DEHTP)
notation: MEHHTP

Mono-2-ethyl-5-oxohexylterephthalate
notation: MEOHTP

2-Methylhippuric acid
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: MHA2

3-Methylhippuric acid + 4-Methylhippuric acid
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: MHA34

N-Acetyl-S-(1-hydroxymethyl-2-propenyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: MHBMA1

N-Acetyl-S-(2-hydroxy-3-butenyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: MHBMA2

N-Acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: MHBMA3

Cyclohexane-1,2-dicarboxylic acid mono hydroxyisononyl ester (DINCH)
notation: MHNCH

monoisononyl phthalate
type: Class
subclass of: Phthalate
editorial note: Duplicate of mINP?
notation: MIP

monooxoisononyl phthalate (DiNP)
notation: MONP

Mono-n-pentyl phthalate
type: Class
subclass of: Phthalate
editorial note: Duplicate of mPeP?
notation: MPP

trans, trans -Muconic acid
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: MU

Malarial Retinopathy
type: QualityValue
type: Class
subclass of: Retinopathy
definition: Retinopathy due to malaria.
notation: 130

Maternal Weight Gain
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Pregnancy Characteristic
subclass of: Weight
definition: The amount of weight gained during a pregnacy.

Metabolite
type: Class
subclass of: Small Molecule
definition: The intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and pheromones). A primary metabolite is directly involved in normal "growth", development, and reproduction. Ethylene is an example of a primary metabolite produced in large-scale by industrial microbiology. A secondary metabolite is not directly involved in those processes, but usually has an important ecological function. Examples include antibiotics and pigments such as resins and terpenes etc. Some antibiotics use primary metabolites as precursors, such as actinomycin which is created from the primary metabolite, tryptophan.

MicroPEM
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Exposure Monitoring Instrument
definition: The MicroPEM device monitors individual exposures to very fine airborne particles—or particulate matter—at two sizes. PM10 has a diameter of less than 10 micrometers (PM10), which is approximately 1/30th the size of a human hair, and PM2.5, which at diameters of less than 2.5 micrometers, is even smaller.

Microwave Oven Count
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Household Appliance Count
definition: Number of machines in the home used to heat up food using microwaves.
editorial note: Putting a note here, but it applies to all of the appliances. These are used to calculate the SES Index that was reported within one of the pilots. So, there needs to be some connection between these terms.

Mother
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Restriction
    on property: hasAttribute
    some values from: Female
  on property: isRoleOf
subclass of: Parent
definition: A mother is the female parent of a child. Mothers are women who inhabit or perform the role of bearing some relation to their children, who may or may not be their biological offspring. Thus, dependent on the context, women can be considered mothers by virtue of having given birth, by raising their child(ren), supplying their ovum for fertilisation, or some combination thereof. Such conditions provide a way of delineating the concept of motherhood, or the state of being a mother. Women who meet the third and first categories usually fall under the terms 'birth mother' or 'biological mother', regardless of whether the individual in question goes on to parent their child. Accordingly, a woman who meets only the second condition may be considered an adoptive mother, and those who meet only the third a surrogacy mother. The above concepts defining the role of mother are neither exhaustive nor universal, as any definition of 'mother' may differ based on how social, cultural, and religious roles are defined.

Multiplex real-time PCR
type: Class
subclass of: Polymerase Chain Reaction

Nicotine (total)
type: Class
subclass of: Tobacco Metabolite
editorial note: To Do: align with CHEBI.
notation: NICT

4-(methlynitrosamino)-1-(3-pyridyl)-1-butanol
type: Class
subclass of: Tobacco Metabolite
editorial note: To Do: align with CHEBI.
notation: NNAL

Neighbor
type: Class
subclass of: Restriction
  all values from: Class
    intersection of: Human
  on property: inRelationTo
subclass of: Demographic
subclass of: Role
definition: A person living near or next door to another person.

Neighborhood Characteristic
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Neighborhood Characteristic Indicator Class

Neurocognitive Assessment
type: Class
subclass of: Physical and Mental Assessment

No Anti Malarial Use
type: QualityValue
type: Class
subclass of: Prescription Medication and Dietary Supplements
notation: 140

No Formal Education
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Education
definition: Has not been educated in a formal setting.
notation: 57

Non-Hispanic Ethnicity
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Ethnicity
definition: Non-Hispanic Ethnicity
notation: 58

Non-Spontaneous Preterm Birth
type: QualityValue
type: Class
subclass of: Preterm Birth
notation: 60

Normal Weight
type: QualityValue
type: Class
subclass of: Restriction
  on property: isAttributeOf
  some values from: Restriction
    on property: hasAttribute
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        on property: STATO_0000129
        some values from: Datatype
subclass of: Body Weight Quality
subclass of: Underweight/Normal
definition: 18.5<=BMI<=25
notation: 61

Not Current Student
type: QualityValue
type: Class
subclass of: StatusDescriptor
definition: The state of an individual not currently engaged in educational activity as a pupil.
notation: 141

Nulliparous
type: QualityValue
type: Class
subclass of: Parity
notation: 62

Used Only Anti Malarials or No Medications
type: QualityValue
type: Class
subclass of: Prescription Medication and Dietary Supplements
notation: 139

Other GI Disease
type: QualityValue
type: Class
subclass of: Medical History
subclass of: Disease
editorial note: This is a temp concept that needs addressing
notation: 69

Other Material Finish
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Floor Type
definition: Flooring is made from another unspecified material.
notation: 70

3-phenoxybenzoic acid
type: Class
subclass of: Alkyl Phosphate Pesticide Metabolite
editorial note: To Do: align with CHEBI.
notation: PBA

2,2',4,4',5,5'-Hexabromobiphenyl
type: Class
subclass of: Polybrominated Diphenyl Ether
editorial note: To Do: align with CHEBI.
notation: PBB153

PCB138
type: Class
subclass of: Polychlorobiphenyl
notation: PCB138

PCB180
type: Class
subclass of: Polychlorobiphenyl
notation: PCB180

Perfluroundecanoic acid
type: Class
subclass of: PFC
notation: PFUNDA

Phenylglyoxylic acid
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: PGA

N-Acetyl-S-(1-phenyl-2-hydroxyethyl-L-cysteine + N-Acetyl-S-(2-phenyl-2-hydroxyethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: PHEMA

2-hydroxyphenanthrene + 3-hydroxyphenanthrene
notation: PHEN2PHEN3

2-hydroxyphenanthrene + 3-hydroxyphenanthrene
type: Class
subclass of: Environmental Phenol
notation: PHEN2_PHEN3

Phenanthrene tetrol
notation: PHET

N-Acetyl-S-(phenyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: PMA

Proton Pump Inhibitor Treatment
type: QualityValue
type: Class
subclass of: Medical Therapy Procedure
definition: Proton Pump Inhibitor Treatment as a form of medical therapy.
editorial note: UPDATE: Yes, add the prescription medication, either as an indicator or as a class under Medical Therapy. Whichever works for the ontology. Why isn't this listed under prescription medication? How do you differentiate between medical therapy and prescription medication?
notation: 27

Parental Health and Family History
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Parental Health and Family History Indicator Class

Parous
type: QualityValue
type: Class
subclass of: Parity
notation: 73

Perfume Use
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Personal Product Use
notation: 74

Peripheral Blood Mononuclear Cell
type: Class
subclass of: Cell
definition: Any peripheral blood cell having a round nucleus. These cells consist of lymphocytes (T cells, B cells, NK cells) and monocytes, whereas erythrocytes and platelets have no nuclei, and granulocytes (neutrophils, basophils, and eosinophils) have multi-lobed nuclei.

Physical Activity and Fitness
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Physical Activity and Fitness Indicator Class

Planned Caesarian Section
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Caesarian Section
definition: Planned caesarian section.
notation: 18

Post-Pregnancy
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Class
    intersection of: Birthing
  on property: inRelationTo
subclass of: FromBirth
subclass of: TimeInterval
definition: The period after birth.

Pre-Pregnancy
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Class
    intersection of: Conceiving
  on property: inRelationTo
subclass of: FromConception
subclass of: TimeInterval
definition: The time before a pregnancy.

Preschool
type: QualityValue
type: Class
subclass of: Education Grade
definition: Finished preschool
notation: 112

Pregnancy
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Class
    intersection of: Conceiving
  on property: inRelationTo
subclass of: FromConception
subclass of: Pregnancy Characteristic
subclass of: TimeInterval
definition: The time during which one or more offspring develops inside a woman.

Pregnancy Cohort Study
type: Class
subclass of: CohortStudy

Pregnancy Complication
type: QualityValue
type: Class
subclass of: Pregnancy Characteristic
notation: 75

Private Insurance
type: QualityValue
type: Class
subclass of: Private Insurance or Self Pay
notation: 103

Public Insurance
type: QualityValue
type: Class
subclass of: Insurance
notation: 79

Quadrapole Time-of-Flight Liquid Chromotography-Mass Spectrometry
type: Class
subclass of: Liquid Chromotography-Mass Spectrometery

Quit Smoking After Pregnancy
type: QualityValue
type: Class
subclass of: Pregnancy Characteristic
subclass of: Prenatal Smoker
subclass of: Quit Smoking
definition: Quit Smoking After Pregnancy
notation: 80

Quit Smoking Before Pregnancy
type: QualityValue
type: Class
subclass of: Pregnancy Characteristic
subclass of: Prenatal Nonsmoker
subclass of: Quit Smoking
definition: A Previous Smoker who Quit Smoking Before Pregnancy
notation: 81

RNA Sequencing
type: Class
subclass of: Nucleic Acid Sequencing

Reichert AR200 Handheld Digital Refractometer
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Refractometer
definition: Lightweight digital refractometer designed for the food, beverage, agricultural, industrial-fluid, chemical, petrochemical, pharmaceutical, medical, and plastic industries.

Religion
type: QualityVariable
type: Class
subclass of: Demographic
definition: Religious Belief

Repeat Caesarian Section
type: QualityValue
type: Class
subclass of: Caesarian Section
definition: Had Repeat Caesarian Section
notation: 21

Replicate Number
type: Class
subclass of: SampleIndicator
definition: Replicate Number

Reproductive Health
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Reproductive Health Indicator Class

Reverse-Phase Mass Spectrometry Profiling
type: Class
subclass of: MassSpectrometry

Surface-Induced Dissociation (SID)
type: Class
subclass of: TandemMassSpectrometry

Mercapturic acid of benzene
type: Class
subclass of: PAH
notation: SPMA

A Sample has a Pairing
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Sampling
definition: Refers to having paired samples.
editorial note: This actually should be a process. What should we do?

Screening
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: TimeInterval
definition: The time period during which a screening process is used to determine the inclusion of a subject in a study.

Second Trimester
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Class
    intersection of: Conceiving
  on property: inRelationTo
subclass of: FromConception
subclass of: TimeInterval
definition: From week 13 through 28. Around the middle of the second trimester, movement of the fetus may be felt. At 28 weeks, more than 90% of babies can survive outside of the uterus if provided with high-quality medical care.

No Insurance / Self-funded
type: QualityValue
type: Class
subclass of: Private Insurance or Self Pay
notation: 89

Severe Malarial Anemia
type: QualityValue
type: Class
subclass of: Anemia
definition: In holoendemic transmission areas, Severe Malarial Anemia (SMA) is the primary clinical manifestation of severe childhood malaria, with cerebral malaria occurring only in rare cases. Mortality rates from SMA can exceed 30% in pediatric populations residing in holoendemic transmission areas. The pathophysiological processes that contribute to SMA involve direct and indirect destruction of parasitized and non-parasitized red blood cells (RBCs), inefficient and/or suppression of erythropoiesis, and dyserythropoiesis.
notation: 127

Shotgun Lipidomics
type: Class
subclass of: Electrospray Ionization Mass Spectrometry

Sleep Characterisitic
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Sleep Characterisitics Indicator Class

Socioeconomic Status Index
type: QuantityVariable
type: Class
subclass of: Socioeconomic Status
subclass of: Quantity
definition: A measure of SES.
editorial note: This is a specific index, derived from other variables. So, it should somehow be connected to this variables. Also, we may want to be more specific about the type of index that it is. Perhaps there should be a general SESIndex and then subclasses of specific measures?

Soil Floor
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Floor Type
definition: The flooring is made of soil.
notation: 84

Solid-Phase Sandwich ELISA
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Sandwich ELISA

Some High School
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: High School or Less
definition: Education Level of Some High School
notation: 87

Son
type: Class
subclass of: Restriction
  all values from: Restriction
    on property: hasAttribute
    some values from: Male
  on property: isRoleOf
subclass of: Child
definition: A son is a male offspring; a boy or man in relation to his parents.

SpectraMax Plus 384 Microplate Reader
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Microplate Reader
definition: Get absorbance measurements from 190 to 1000 nm quickly for samples in test tubes, cuvettes, and 96- or 384-well microplates. The SpectraMax® Plus 384 Microplate Reader gives you walk-up convenience for both standard spectrophotometer and microplate reader applications on the same instrument. Monochromator wavelength selection saves you the time and trouble of ever having to change out filters. Typical applications for this powerful reader include DNA and RNA quantification, enzyme kinetic assays, and ELISA based assays. When your project is ready for high throughput, take advantage of StakMax® automated microplate handling compatibility for full robotic integration.

Spontaneous Caesarian Section
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Caesarian Section
definition: Had a spontaneous caesarian section
notation: 22

Spontaneous Preterm Birth
type: QualityValue
type: Class
subclass of: Preterm Birth
notation: 91

Step
type: Class
subclass of: Non-Biological Relative
definition: A stepfamily is a family where at least one parent has children that are not genetically related to the other spouse or partner. Either one parent may have children from a previous relationship. Children in a stepfamily may live with one biological parent, or they may live with each biological parent for a period of time. In addition, visitation rights mean that children in stepfamilies often have contact with both biological parents, even if they permanently live with only one. A child is referred to as the stepchild, stepdaughter or stepson of their biological parent's new spouse, and that person as the stepparent, stepfather or stepmother of the child. A stepfather is the husband of one's mother, and not one's biological father. A stepmother is the wife of one's father, and not one's biological mother. A step-grandmother is the wife of one's grandfather, and not one's biological grandmother. A step-grandfather is the husband of one's grandmother, and not one's biological grandfather. Similarly, a stepbrother is the son of a stepparent who one is not biologically related to. A stepsister is the daughter of a stepparent to whom one is not biologically related. A step-grandson is the son of a stepson or stepdaughter who one is not biologically related to. A step-granddaughter is the daughter of a stepson or stepdaughter who one is not biologically related. A parent's spouse of the same sex may also count as a stepparent.

Steroid Treatment form of Medical Therapy
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Medical Therapy Procedure
definition: Had a form of treatment which uses steroids.
notation: 28

Stress
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Stress Frequency
definition: Whether or not a person gets stressed.
notation: 92

Study Baseline
type: Class
subclass of: TimeInterval
definition: Point in study set to initial point.

Subject
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Class
    intersection of: Study
  on property: inRelationTo
subclass of: Role
definition: A living individual about whom a research investigator (whether a professional or a student) obtains data through 1) intervention or interaction with the individual, or 2) identifiable private information

3,5,6-trichloro-2-pyridinol
type: Class
subclass of: Alkyl Phosphate Pesticide Metabolite
editorial note: To Do: align with CHEBI.
notation: TCP

N-Acetyl-S-(trichlorovinyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: TCVMA

Total nicotine
type: Class
subclass of: Tobacco Metabolite
editorial note: Duplicate of NIC?
notation: TNIC

2-Thioxothiazolidine-4-carboxylic acid
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: TTCA

Targeted Sequencing
type: Class
subclass of: Nucleic Acid Sequencing
definition: Nucleic acid sequencing that limits the scope of sequencing by filtering out portions of the nucleic acids that do not meet some criteria.

2,4,5,6-Tetrachlorophenol
type: Class
subclass of: Environmental Phenol
definition: PHYSICAL DESCRIPTION: Brown flakes or beige solid. Strong odor. (NTP, 1992)
notation: TeCP2456

Technical Post Junior College
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Technical School
subclass of: Education
definition: Attended a Technical Post Junior College
notation: 93

Technical Post-Middle School
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: High School or Less
subclass of: Technical School
definition: Attended a Technical Post-Middle School.
notation: 94

Technical Post Primary School
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: High School or Less
subclass of: Technical School
definition: Attended a Technical Post Primary School
notation: 95

TermBirth
type: QualityValue
type: Class
subclass of: Birth Outcome
notation: 97

Third Trimester
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Class
    intersection of: Conceiving
  on property: inRelationTo
subclass of: FromConception
subclass of: TimeInterval
definition: From 29 weeks through 40 weeks.

Toaster Count
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Household Appliance Count
definition: Number of appliances used to toast bread.

Tobacco Smoke Exposure
type: QualityValue
type: Class
subclass of: Environmental Exposure
notation: 98

Tri-Cell DMA-80 Direct Mercury Analyzer
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Direct Mercury Analyzer
definition: The DMA-80 is based on the principles of sample thermal decomposition, mercury amalgamation and atomic absorption detection. The DMA-80 has been used to develop the US EPA method 7473 (Mercury in solids and solutions by thermal decomposition, amalgamation, and atomic absorption spectrophotometry). It is furthermore compliant with ASTM method D-6722-01 (Total mercury in coal and coal combustion residues) and ASTM method D-7623-10 (Total mercury in crude oil).

Immunoturbidimetry
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Assay
definition: An analytical technique that uses light scattering, a physical phenomenon resulting from the interaction of light with particles in solution, to measure the concentration of particles. The photometric signal is generated by a decrease in light intensity as a direct consequence of increasing turbidity in the reaction well. Immunoturbidimetry uses the classical antigen-antibody reaction. The antigen-antibody complexes are particles which can be optically detected by an photometer.

Ultra-Performance Liquid Chromatography - Tandem Mass Spectrometer
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Tandem Mass Spectrometer
subclass of: Ultra Performance Liquid Chromatography - Mass Spectrometer

Unknown Education Level
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Education
definition: Level of Education is not known
notation: 101

Unknown Race
type: QualityValue
type: Class
subclass of: Race
definition: Unknown Race
notation: 48

Unplanned Caesarian Section
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Caesarian Section
definition: Had an unplanned caesarian section.
notation: 23

VCR Player Count
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Household Appliance Count
definition: Number of devices that play VCRs in the home.

N-acel-S-(1,2-dichlorovinl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOC1DC

N-Acel-S-(2,2-Dichlorvinyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOC2DC

2-Methylhippuric acid (ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOC2MH

3-methipurc acd & 4-methipurc acd(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOC34M

N-Ace-S-(2-carbamoylethyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCAAM

N-Ace-S-(N-methlcarbamoyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCAMC

2-amnothiazolne-4-carbxylic acid(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCATC

N-Acetyl-S-(benzyl)-L-cysteine(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCBMA

N-Acetyl-S-(n-propyl)-L-cysteine(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCBPM

N-Acetyl-S-(2-Carbxyethyl)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCCEM

N-acetyl-S-(2-cyanoethyl)-L-cyst(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCCYM

N-Ace-S- (3,4-Dihidxybutl)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCDHB

N-Ace-S-(dimethylphenyl)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCDPM

N-ac-S-(2-carbmo-2-hydxel)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCGAM

N-Ace-S-(2-Hydroxyethyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCHEM

N-Ace-S-(2-hydroxypropyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCHP2

N-Ace-S-(3-Hydroxypropyl)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCHPM

Mandelic acid(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCMAD

N-A-S-(1-HydrxMet)-2-Prpn)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCMB1

N-Ac-S-(2-Hydrxy-3-butnyl)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCMB2

N-ace-S-(phenl-2-hydxyetl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCMB3

t,t-Muconic acid(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCMUC

N-ace-S-(phenl-2-hydxyetl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCPHE

Phenylglyoxylic acid(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCPHG

N-Acetyl-S-(phenyl)-L-cysteine(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCPMA

N-A-S-(3-hydrxprpl-1-metl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCPMM

N-Acetyl-S-(trichlorovinyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCTCV

2-thoxothazlidne-4-carbxylic acid(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCTTC

Vacuum Cleaner Count
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Household Appliance Count
definition: Number of appliances in home used for cleaning rugs.

Visit
type: Class
subclass of: TimeInterval
definition: The time interval of an encounter between a study subject and a study administrator.

Washing Machine Count
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Household Appliance Count
definition: Number of machines used for washing clothes in the home.

Weight for Height Z-Score
type: QuantityVariable
type: Class
subclass of: Z-Score
subclass of: StandardScore
definition: Z-Score of the weight/height ratio at a given age.

Fenton Weighted Z-Score
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Class
  intersection of: StandardScore
  intersection of: Restriction
    on property: wasDerivedFrom
    some values from: BirthWeight
  intersection of: Restriction
    on property: wasDerivedFrom
    some values from: Fenton Preterm Growth Chart
  intersection of: Restriction
    on property: wasDerivedFrom
    some values from: Gestational Age at Birth
subclass of: Birth Outcome
subclass of: Z-Score
subclass of: StandardScore
definition: Derived from Birth Weight, Gestational Age, and Child Sex

billion parts per microgram
type: UnitOfMeasurement
notation: x109 µL

HOMA-IR
type: UnitOfMeasurement
notation: (mg/dL)*(µU/mL)

international units per litre
type: UnitOfMeasurement
notation: IU/L

mono-benzyl phthalate
type: Class
subclass of: Phthalate
editorial note: Is this a repeat of MBP?
notation: mBzP

mono(7-carboxyheptyl)phthalate
type: Class
subclass of: Phthalate
notation: mCHpP

mono-carboxy isononyl phthalate
type: Class
subclass of: Phthalate
notation: mCINP

mono-carboxy isooctyl phthalate
type: Class
subclass of: Phthalate
notation: mCIOP

mono-(2-ethyl-5-carboxypentyl) phthalate
type: Class
subclass of: Phthalate
editorial note: Duplicate of MCEPP?
notation: mECPP

mono-2-heptyl phthalate
type: Class
subclass of: Phthalate
notation: mHpP

mono-isodecyl phthalate
type: Class
subclass of: Phthalate
notation: mIDP

mono-isopropyl phthalate
type: Class
subclass of: Phthalate
editorial note: Duplicate of MiPP?
notation: mIPrP

micrograms per deciliter
type: UnitOfMeasurement
notation: µg/dl

microgram per gram
type: UnitOfMeasurement
notation: ug/g

micrograms per meter cubed
type: UnitOfMeasurement
notation: µg/m3

micromole per liter
type: UnitOfMeasurement
notation: µmol/L

microunits per milliliter
type: UnitOfMeasurement
notation: µU/mL

milligram per deciliter
type: UnitOfMeasurement
notation: mg/dl

milligram per gram
type: UnitOfMeasurement
notation: mg/g

millimole per liter
type: UnitOfMeasurement
notation: mmol/L

million parts per microgram
type: UnitOfMeasurement
notation: x106 µL

nanograms per liter
type: UnitOfMeasurement
notation: ng/L

parasites per microgram
type: UnitOfMeasurement
notation: parasites/µL

picograms per milliliter
type: UnitOfMeasurement
notation: pg/mL

picomoles per milliliter
type: UnitOfMeasurement
notation: pmol/ml

thousand parts per microgram
type: UnitOfMeasurement
notation: x103 µL

Cis-Nonachlor
type: Class
subclass of: Organochlorine Compound
notation: CNON

Perfluorooctanesulfonamide
type: Class
subclass of: PFC
notation: PFOSA

hexadecanoic acid
type: Class
subclass of: Fatty Acid
definition: A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
notation: C160

arachidonic acid
type: Class
subclass of: Fatty Acid
definition: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.
notation: C204N6

Ethylbenzene
type: Class
subclass of: Volatile Organic Compound
definition: Ethylbenzene is mainly used in the manufacture of styrene. Acute (short-term) exposure to ethylbenzene in humans results in respiratory effects, such as throat irritation and chest constriction, irritation of the eyes, and neurological effects such as dizziness. Chronic (long-term) exposure to ethylbenzene by inhalation in humans has shown conflicting results regarding its effects on the blood. Animal studies have reported effects on the blood, liver, and kidneys from chronic inhalation exposure to ethylbenzene. Limited information is available on the carcinogenic effects of ethylbenzene in humans. In a study by the National Toxicology Program (NTP), exposure to ethylbenzene by inhalation resulted in an increased incidence of kidney and testicular tumors in rats, and lung and liver tumors in mice. EPA has classified ethylbenzene as a Group D, not classifiable as to human carcinogenicity.
notation: EB

4,4'-DDT
type: Class
subclass of: Organochlorine Compound
notation: PPDDT

oleic acid
type: Class
subclass of: Fatty Acid
definition: An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.
notation: C181N9

Triclosan
type: Class
subclass of: Environmental Phenol
definition: Triclosan is a diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.
notation: TCS

4,4'-DDE
type: Class
subclass of: Organochlorine Compound
notation: PPDDE

Benzene
type: Class
subclass of: Volatile Organic Compound
definition: Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
notation: BZ

Creatinine
type: Class
subclass of: Targeted Analyte
definition: Creatinine is the breakdown product of creatine, a constituent of muscle tissue, that is excreted by the kidney and whose serum level is used to evaluate kidney function.
notation: CRE

2,4-Dichlorophenol
type: Class
subclass of: Environmental Phenol
definition: 2,4-dichlorophenol is a colorless crystalline solid with a medicinal odor. Melting point 45°C. Sinks in water. Strong irritant to tissues; toxic by ingestion.
notation: DCP24

Inorganic Mercury (Hg2+)
type: Class
subclass of: Mercury Species
notation: Hg2

dehydroepiandrosterone sulfate
type: Class
subclass of: Analyte
definition: A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone.

glucose
type: Class
subclass of: Analyte
definition: An aldohexose used as a source of energy and metabolic intermediate.

mono ethyl hexyl phthalate
type: Class
subclass of: Phthalate
definition: PHYSICAL DESCRIPTION: Clear colorless to cloudy white viscous liquid. (NTP, 1992)
notation: MEHP

Tetrachloroethene
type: Class
subclass of: Volatile Organic Compound
definition: TETRACHLOROETHYLENE is a chlorinated hydrocarbon used as an industrial solvent and cooling liquid in electrical transformers. It is a potential carcinogen.
notation: TCE

linoleic acid
type: Class
subclass of: Fatty Acid
definition: An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.
notation: C182N6

Toluene
type: Class
subclass of: Volatile Organic Compound
definition: Toluene is a widely used industrial solvent.
notation: TOL

Pentachlorophenol
type: Class
subclass of: Environmental Phenol
definition: An insecticide and herbicide that has also been used as a wood preservative. Pentachlorphenol is a widespread environmental pollutant. Both chronic and acute pentachlorophenol poisoning are medical concerns. The range of its biological actions is still being actively explored, but it is clearly a potent enzyme inhibitor and has been used as such as an experimental tool.
notation: PCP

Arsenic (V) Acid
type: Class
subclass of: Arsenic Species
notation: Arsenic (V) Acid

Manganese
type: Class
subclass of: Metal
definition: MANGANESE is a trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
notation: Mn

Nicotine
type: Class
subclass of: Tobacco Metabolite
definition: Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
notation: NIC

2-hydroxyphenanthrene
type: Class
subclass of: PAH
notation: PHEN2

3-hydroxyphenanthrene
type: Class
subclass of: PAH
notation: PHEN3

4-hydroxyphenanthrene
type: Class
subclass of: PAH
notation: PHEN4

Cadmium
type: Class
subclass of: Metal
definition: An element with atomic symbol Cd, atomic number 48, and atomic weight 114. It is a metal and ingestion will lead to CADMIUM POISONING.
notation: Cd

cyclic peptide
type: Class
subclass of: Analyte
definition: A molecular entity capable of accepting a hydron from a donor (Bronsted acid).

Lead
type: Class
subclass of: Metal
definition: LEAD is a soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.19, symbol Pb. (Dorland, 28th)
notation: Pb

Magnesium
type: Class
subclass of: Metal
definition: An element with atomic symbol Mg, atomic number 12, and atomic weight 24.3. Magnesium is an alkaline earth metal and is important to bone structure in human physiology.
notation: Mg

Mercury
type: Class
subclass of: Metal
definition: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
notation: Hg

Tin
type: Class
subclass of: Metal
definition: TIN is a trace element that is required in bone formation. It has the atomic symbol Sn, atomic number 50, and atomic weight 118.71.
notation: Sn

Anatabine
type: Class
subclass of: Tobacco Metabolite
notation: ANAT

Trimethylarsine oxide
type: Class
subclass of: Arsenic Species
notation: Trimethylarsine oxide

Uranium
type: Class
subclass of: Metal
definition: Uranium. A radioactive element of the actinide series of metals. URANIUM has an atomic symbol U, atomic number 92, and atomic weight 238.03. U-235 is used as the fissionable fuel in nuclear weapons and as fuel in nuclear power reactors.
notation: U

Vitamin D
type: Class
subclass of: Biomolecule
subclass of: Diet and Nutrition
definition: Vitamin D is a group of fat-soluble prohormones, which can be obtained from sun exposure, food and supplements. Vitamin D is biologically inactive and converted to the biologically active calcitriol via double hydroxylation in the body.

Zinc
type: Class
subclass of: Metal
definition: A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
notation: Zn

Carbon Tetrachloride
type: Class
subclass of: Volatile Organic Compound
definition: CARBON TETRACHLORIDE is a solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
notation: CTET

p-Xylene*
type: Class
subclass of: Volatile Organic Compound
definition: P-xylene is a colorless watery liquid with a sweet odor. Less dense than water. Insoluble in water. Irritating vapor. Freezing point is 56°F. (USCG, 1999)
notation: PXY

alpha-linolenic acid
type: Class
subclass of: Fatty Acid
definition: A linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect.
notation: C183N3

Styrene
type: Class
subclass of: Volatile Organic Compound
definition: STYRENE is a colorless, toxic liquid with a strong aromatic odor. It is used to make rubbers, polymers and copolymers, and polystyrene plastics.
notation: STY

1-hydroxyphenanthrene
type: Class
subclass of: PAH
notation: PHEN1

Boron
type: Class
subclass of: Metal
definition: A trace element with the atomic symbol B, atomic number 5, and atomic weight [10.806; 10.821]. Boron-10, an isotope of boron, is used as a neutron absorber in BORON NEUTRON CAPTURE THERAPY.
notation: B

Arsenic
type: Class
subclass of: Metal
definition: A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)
notation: As

Selenium
type: Class
subclass of: Metal
definition: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.
notation: Se

Cobalt
type: Class
subclass of: Metal
definition: COBALT is a trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
notation: Co

Vanadium
type: Class
subclass of: Metal
definition: A metallic element with the atomic symbol V, atomic number 23, and atomic weight 50.94. It is used in the manufacture of vanadium steel. Prolonged exposure can lead to chronic intoxication caused by absorption usually via the lungs.
notation: V

1,2-Dichloroethane
type: Class
subclass of: Volatile Organic Compound
definition: Ethylene Dichloride is a clear, colorless, oily, synthetic, flammable liquid chlorinated hydrocarbon with a pleasant chloroform-like smell that emits toxic fumes of hydrochloric acid when heated to decomposition. Ethylene dichloride is primarily used to produce vinyl chloride. Inhalation exposure to this substance induces respiratory distress, nausea and vomiting and affects the central nervous system, liver and kidneys. It is mutagenic in animals and is reasonably anticipated to be a human carcinogen. (NCI05)
notation: DE12

2,5-Dichlorophenol
type: Class
subclass of: Environmental Phenol
definition: PHYSICAL DESCRIPTION: Prisms (from benzene, petroleum ether) or white crystals. Odor threshold 30 µg/L at 68-72°F; 33 µg/L at 86°F. Taste threshold 0.5 µg/L. (NTP, 1992)
notation: DCP25

Tungsten
type: Class
subclass of: Metal
definition: Tungsten. A metallic element with the atomic symbol W, atomic number 74, and atomic weight 183.85. TUNGSTEN is used in many manufacturing applications, including increasing the hardness, toughness, and tensile strength of steel; manufacture of filaments for incandescent light bulbs; and in contact points for automotive and electrical apparatus.
notation: W

o-Xylene
type: Class
subclass of: Volatile Organic Compound
definition: O-xylene is a colorless watery liquid with a sweet odor. Less dense than water. Insoluble in water. Irritating vapor. (USCG, 1999)
notation: OXY

Chromium
type: Class
subclass of: Metal
definition: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.
notation: Cr

4-Chlorophenol
type: Class
subclass of: Environmental Phenol
definition: P-chlorophenol is a white crystals with a strong phenol odor. Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible. Used as an intermediate in organic synthesis of dyes and drugs.
notation: MCP4

Nickel
type: Class
subclass of: Metal
definition: NICKEL is a trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.
notation: Ni

all-cis-docosa-4,7,10,13,16,19-hexaenoic acid
type: Class
subclass of: Fatty Acid
definition: A docosahexaenoic acid having six cis-double bonds at positions 4, 7, 10, 13, 16 and 19.
notation: C226N3

Nornicotine
type: Class
subclass of: Tobacco Metabolite
notation: NORN

all-cis-5,8,11,14,17-icosapentaenoic acid
type: Class
subclass of: Fatty Acid
definition: An icosapentaenoic acid having five cis-double bonds at positions 5, 8, 11, 14 and 17.
notation: C205N3

beta-hexachlorocyclohexane
type: Class
subclass of: Organochlorine Compound
notation: BHCH

m-Xylene*
type: Class
subclass of: Volatile Organic Compound
definition: M-xylene is a colorless watery liquid with a sweet odor. Less dense than water. Insoluble in water. Irritating vapor. (USCG, 1999)
notation: MXY

2,4,5-Trichlorophenol
type: Class
subclass of: Environmental Phenol
definition: Exposure to 2,4,5-trichlorophenol may occur during its production or use as a pesticide. Acute (short-term) dermal exposure to 2,4,5-trichlorophenol may burn skin in humans. It also irritates the eyes, nose, pharynx, and lungs in humans. No information is available on the chronic (long-term), reproductive, developmental, or carcinogenic effects of 2,4,5-trichlorophenol in humans. In one study, slight degenerative changes were observed in the liver and kidneys of rats chronically exposed to 2,4,5-trichlorophenol in their diet. EPA has classified 2,4,5-trichlorophenol as a Group D, not classifiable as to human carcinogenicity. PHYSICAL DESCRIPTION: Colorless needles, gray flakes or off-white lumpy solid. Phenolic odor. Formerly used as a fungicide and bactericide.
notation: TCP245

gamma-linolenic acid
type: Class
subclass of: Fatty Acid
definition: A C18, ω-6 acid fatty acid comprising a linolenic acid having cis- double bonds at positions 6, 9 and 12.
notation: C183N6

Molybdenum
type: Class
subclass of: Metal
definition: MOLYBDENUM is a metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.94. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase. (From Dorland, 27th ed)
notation: Mo

Copper
type: Class
subclass of: Metal
definition: COPPER is a heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
notation: Cu

(9Z)-hexadecenoic acid
type: Class
subclass of: Fatty Acid
definition: A hexadecenoic acid with a cis-double bond at position C-9.
notation: C161N7

2,4,6-Trichlorophenol
type: Class
subclass of: Environmental Phenol
definition: 2 4 6-Trichlorophenol is a synthetic, colorless crystalline solid that is slightly soluble in water and soluble in organic solvents. It has been used primarily in pesticide formulations and as a wood preservative, although most uses have been cancelled in the US. When heated to decomposition, 2,4,6-trichlorophenol emits toxic and corrosive fumes of hydrochloric acid and other toxic gases. Exposure of humans to 2,4,6-trichrophenol via inhalation has been reported to cause respiratory effects, altered pulmonary function and pulmonary lesions. It is reasonably anticipated to be a human carcinogen. (NCI05)
notation: TCP246

octadecanoic acid
type: Class
subclass of: Fatty Acid
definition: A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and plastics.
notation: C180

tetracosanoic acid
type: Class
subclass of: Fatty Acid
definition: A C24 straight-chain saturated fatty acid.
notation: C240

tetradecanoic acid
type: Class
subclass of: Fatty Acid
definition: A straight-chain, fourteen-carbon, long-chain saturated fatty acid mostly found in milk fat.
notation: C140

docosanoic acid
type: Class
subclass of: Fatty Acid
definition: A straight-chain, C22, long-chain saturated fatty acid.
notation: C220

Aluminum
type: Class
subclass of: Metal
definition: ALUMINUM is a metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.
notation: Al

phthalic acid
type: Class
subclass of: Phthalate
definition: PHYSICAL DESCRIPTION: White crystals or fine white powder. (NTP, 1992)
notation: PA

Gold
type: Class
subclass of: Metal
definition: GOLD is a yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.
notation: Au

Monomethylarsonic Acid
type: Class
subclass of: Arsenic Species
notation: Monomethylarsonic Acid

Lithium
type: Class
subclass of: Metal
definition: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.
notation: Li

Thallium
type: Class
subclass of: Metal
definition: THALLIUM is a heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.
notation: Tl

Tellurium
type: Class
subclass of: Metal
definition: Tellurium. An element that is a member of the chalcogen family. TELLURIUM has the atomic symbol Te, atomic number 52, and atomic weight 127.60. It has been used as a coloring agent and in the manufacture of electrical equipment. Exposure may cause nausea, vomiting, and CNS depression.
notation: Te

Beryllium
type: Class
subclass of: Metal
definition: Beryllium. An element with the atomic symbol Be, atomic number 4, and atomic weight 9.01218. Short exposure to this element can lead to a type of poisoning known as BERYLLIOSIS.
notation: Be

Silver
type: Class
subclass of: Metal
definition: Silver. An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.
notation: Ag

Antimony
type: Class
subclass of: Metal
definition: ANTIMONY is a metallic element that has the atomic symbol Sb, atomic number 51, and atomic weight 121.75. It is used as a metal alloy and as medicinal and poisonous salts. It is toxic and an irritant to the skin and the mucous membranes.
notation: Sb

Cesium
type: Class
subclass of: Metal
definition: A member of the alkali metals. It has an atomic symbol Cs, atomic number 50, and atomic weight 132.91. Cesium has many industrial applications, including the construction of atomic clocks based on its atomic vibrational frequency.
notation: Cs

Ruthenium
type: Class
subclass of: Metal
definition: RUTHENIUM is a hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.
notation: Ru

4-Hydroxybenzoic acid
type: Class
subclass of: Environmental Phenol
notation: HB4

Ethyl paraben
type: Class
subclass of: Paraben
definition: Ethylparaben is a Standardized Chemical Allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of ethylparaben is Allergens.
notation: EtPB

Methyl Paraben
type: Class
subclass of: Paraben
definition: Methylparaben is a Standardized Chemical Allergen. The physiologic effect of methylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of methylparaben is Allergens.
notation: MePB

Propyl paraben
type: Class
subclass of: Paraben
definition: Propylparaben is a Standardized Chemical Allergen. The physiologic effect of propylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of propylparaben is Allergens.
notation: PrPB

Barium
type: Class
subclass of: Metal
definition: BARIUM is an element of the alkaline earth group of metals. It has an atomic symbol Ba, atomic number 56, and atomic weight 138. All of its acid-soluble salts are poisonous.
notation: Ba

gamma-hexachlorocyclohexane
type: Class
subclass of: Organochlorine Compound
notation: GHCH

8-isoprostane
type: Class
subclass of: Biological Response
subclass of: Biomolecule

Iodine
type: Class
subclass of: Element
definition: Iodine is a nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
notation: I

Ethyl mercury (C2H5Hg+)
type: Class
subclass of: Mercury Species
notation: C2H5Hg

Bisphenol A
type: Class
subclass of: Environmental Phenol
definition: 4,4'-isopropylidenediphenol is a white to light brown flakes or powder. Has a weak medicine odor. Sinks in water. (USCG, 1999)
notation: BPA

Bismuth
type: Class
subclass of: Metal
definition: BISMUTH is a metallic element that has the atomic symbol Bi, atomic number 83 and atomic weight 208.98.
notation: Bi

Strontium
type: Class
subclass of: Metal
definition: STRONTIUM is an element of the alkaline earth family of metals. It has the atomic symbol Sr, atomic number 38, and atomic weight 87.62.
notation: Sr

Titanium
type: Class
subclass of: Metal
definition: TITANIUM is a dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)
notation: Ti

Niobium
type: Class
subclass of: Metal
definition: Niobium. A metal element atomic number 41, atomic weight 92.906, symbol Nb. (From Dorland, 28th ed)
notation: Nb

Platinum
type: Class
subclass of: Metal
definition: Platinum. A heavy, soft, whitish metal, resembling tin, atomic number 78, atomic weight 195.09, symbol Pt. (From Dorland, 28th ed) PLATINUM is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae".
notation: Pt

Gadolinium
type: Class
subclass of: Metal
definition: Gadolinium. An element of the rare earth family of metals. GADOLINIUM has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors.
notation: Gd

Neptunium
type: Class
subclass of: Metal
definition: Neptunium. A radioactive element of the actinide metals family. NEPTUNIUM has the atomic symbol Np, atomic number 93, and atomic weight 237.
notation: Np

Plutonium
type: Class
subclass of: Metal
definition: Plutonium. A naturally radioactive element of the actinide metals series. It has the atomic symbol Pu, atomic number 94, and atomic weight 242. Plutonium is used as a nuclear fuel, to produce radioisotopes for research, in radionuclide batteries for pacemakers, and as the agent of fission in nuclear weapons.
notation: Pu

1-hydroxypyrene
type: Class
subclass of: PAH
notation: PYR1

PCB52
type: Class
subclass of: Polychlorobiphenyl
notation: PCB52

Oxybenzone
type: Class
subclass of: Volatile Organic Compound
definition: Oxybenzone is a benzophenone derivative used as a sunscreen agent. Oxybenzone absorbs UVB and UVA II rays, resulting in a photochemical excitation and absorption of energy. Upon return to ground state, the absorbed energy results in emission of longer wavelength radiation and decreased skin penetration of radiation which reduces the risk of DNA damage.
notation: OXB

2-hydroxyfluorene
type: Class
subclass of: PAH
notation: FLUO2

PCB118
type: Class
subclass of: Polychlorobiphenyl
notation: PCB118

PCB101
type: Class
subclass of: Polychlorobiphenyl
notation: PCB101

4-hydroxybenzophenone
type: Class
subclass of: Benzophenone
notation: OH4BP

Benzyl paraben
type: Class
subclass of: Paraben
definition: Benzylparaben is a Standardized Chemical Allergen. The physiologic effect of benzylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of benzylparaben is Allergens.
notation: BzPB

Heptyl paraben
type: Class
subclass of: Paraben
notation: HePB

Mirex
type: Class
subclass of: Organochlorine Compound
notation: MIREX

N-Acetyl-S- (2-hydroxyethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: HEMA2

Hemoglobin
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Protein
definition: The iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates (with the exception of the fish family Channichthyidae), as well as the tissues of some invertebrates. Hemoglobin in the blood carries oxygen from the respiratory organs (lungs or gills) to the rest of the body (i.e. the tissues). There it releases the oxygen to permit aerobic respiration to provide energy to power the functions of the organism in the process called metabolism.

Nitrogen Oxide
type: Class
subclass of: Analyte

Chloroform
type: Class
subclass of: Volatile Organic Compound
definition: CHLOROFORM is a commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.
notation: CFRM

Perfluorodecanoic acid
type: Class
subclass of: PFC
notation: PFDA

Perfluorooctanoic acid
type: Class
subclass of: PFC
notation: PFOA

3,4-Dihydroxy benzoic acid
type: Class
subclass of: Environmental Phenol
notation: DHB34

Antimalarial
type: QualityValue
type: Class
subclass of: Medication
definition: A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.
notation: 120

Perfluorononanoic acid
type: Class
subclass of: PFC
notation: PFNA

3-Chlorophenol
type: Class
subclass of: Environmental Phenol
definition: PHYSICAL DESCRIPTION: White crystals with an odor of phenol. Sinks in and slowly dissolves in water. (NTP, 1992)
notation: MCP3

Cis-Chlordane
type: Class
subclass of: Organochlorine Compound
notation: CCHL

Trans-Chlordane
type: Class
subclass of: Organochlorine Compound
notation: TCHL

alpha-hexachlorocyclohexane
type: Class
subclass of: Organochlorine Compound
notation: AHCH

Perfluorooctanesulfonic acid
type: Class
subclass of: PFC
definition: Perfluoroalkyls are stable, synthetic chemicals. Perfluoroalkyls are unique because they repel oil, grease, and water. The two perfluoroalkyls made in the largest amounts in the U. S. areperflurooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS). Perfluoroalkyls have been used in surface protection products such as carpet and clothing treatments and coating for paper and cardboard packaging. They have also been used in fire-fighting foams.
notation: PFOS

Perfluorobutanoic acid
type: Class
subclass of: PFC
notation: PFBA

8-hydroxy-2'-deoxyguanosine
type: Class
subclass of: Biological Response
subclass of: Biomolecule
definition: Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.

(15Z)-tetracosenoic acid
type: Class
subclass of: Fatty Acid
definition: A tetracosenoic acid having a cis-double bond at position 15.
notation: C241N9

2-Chlorophenol
type: Class
subclass of: Environmental Phenol
definition: 2-chlorophenol is a colorless to amber liquid with an unpleasant, penetrating odor. Density 1.265 g / cm3. Sinks in water and slowly dissolves. Freezing point 7°C (46°F). Boiling point 175°C (347°F).
notation: MCP2

Triclocarban
type: Class
subclass of: Environmental Phenol
definition: Triclocarban is a triclosan analogue with an antibacterial property. Triclocarban exerts its effect by inhibiting the activity of enoyl-(acyl-carrier protein) (ACP) reductase, widely distributed in bacteria, fungi and plants. ACP reductase catalyses the last step in each cycle of fatty acid elongation in the type II fatty acid synthase systems. As a result, this agent interrupts cell membrane synthesis and leads to bacterial growth inhibition.
notation: TCC

Dimethylarsinic Acid
type: Class
subclass of: Arsenic Species
notation: Dimethylarsinic Acid

Methyl mercury (CH3Hg+)
type: Class
subclass of: Mercury Species
notation: CH3Hg

Arsenous ( III) Acid
type: Class
subclass of: Arsenic Species
notation: Arsenous (III) Acid

cis-vaccenic acid
type: Class
subclass of: Fatty Acid
definition: The cis isomer of vaccenic acid.
notation: C181N7

2,3,5,6-Tetrachlorophenol
type: Class
subclass of: Environmental Phenol
definition: PHYSICAL DESCRIPTION: Leaflets (from ligroin) or light beige powder. (NTP, 1992)
notation: TeCP2356

all-cis-icosa-8,11,14-trienoic acid
type: Class
subclass of: Fatty Acid
definition: An icosatrienoic acid having three cis double bonds at positions 8, 11 and 14.
notation: C203N6

(7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid
type: Class
subclass of: Fatty Acid
definition: The all-cis-isomer of a C22 polyunsaturated fatty acid having five double bonds in the 7-, 10-, 13-, 16- and 19-positions.
notation: C225N3

Hexachlorobenzene
type: Class
subclass of: Organochlorine Compound
notation: HCB

Insulin
type: Class
subclass of: Analyte
subclass of: Biological Response
subclass of: Protein
definition: A peptide hormone produced in the pancreas and involved in regulating the metabolism of carbohydrates (particularly glucose) and fats. Commonly thought of as a protein, it consists of two petide chains, one containing 21 amino acid residues and the other containing 30; the chains are joined together by 2 disulfide bonds. Recombinant insulin is identical to human insulin, but is synthesised by inserting the human insulin gene into E. coli, which then produces insulin for human use. It is used in the treatment of type I and type II diabetes.

Cotinine
type: Class
subclass of: Tobacco Metabolite
definition: The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.
notation: COT

monoethyl phthalate (DEP)
type: Class
subclass of: Phthalate
notation: MEP

Hydroxycotinine
type: Class
label: Hydroxycotinine (total)
subclass of: Tobacco Metabolite
notation: HCOT
notation: HCOTT

Trans-Nonachlor
type: Class
subclass of: Organochlorine Compound
notation: TNON

Arsenobetaine
type: Class
subclass of: Arsenic Species
notation: Arsenobetaine

Perfluoro-n-pentanoic acid
type: Class
subclass of: PFC
notation: PFPeA

Perfluorohexanoic acid
type: Class
subclass of: PFC
notation: PFHxA

N-methyl Perfluorooctane sulfonamido acetic acid
type: Class
subclass of: PFC
notation: NMFOSAA

mono-n-butylphthalate (BzBP, DnBP)
type: Class
subclass of: Phthalate
notation: MnBP

Butyl paraben
type: Class
subclass of: Paraben
definition: Butylparaben is a Standardized Chemical Allergen. The physiologic effect of butylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of butylparaben is Allergens.
notation: BuPB

3-hydroxyfluorene
type: Class
subclass of: PAH
notation: FLUO3

mono-methyl phthalate
type: Class
subclass of: Phthalate
notation: mMP

Cell

abnormal cell
type: Class
subclass of: Cell

Red Blood Cell
type: Class
subclass of: Blood Component
definition: A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen.

Platelet
type: Class
subclass of: Blood Component
definition: A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.

cell in vitro
type: Class
subclass of: Cell

Monocyte
type: Class
subclass of: Lymphocyte
definition: Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.

compound eye retinal cell
type: Class
subclass of: Cell

experimentally modified cell in vitro
type: Class
subclass of: Cell

native cell
type: Class
subclass of: Cell

neural cell
type: Class
subclass of: Cell

neuron
type: Class
subclass of: Cell

systolic blood pressure
type: Class
subclass of: SampleIndicator

diastolic blood pressure
type: Class
subclass of: SampleIndicator

red blood cell count
type: Class
subclass of: Count

white blood cell count
type: Class
subclass of: Count

platelet count
type: Class
subclass of: Count

blood lymphocyte count
type: Class
subclass of: Count

blood monocyte count
type: Class
subclass of: Count

hematocrit
type: Class
subclass of: Ratio

skin fold thickness, tricep
type: Class
subclass of: SampleIndicator

skin fold thickness, subscapular
type: Class
subclass of: SampleIndicator

skin fold thickness, suprailiac
type: Class
subclass of: SampleIndicator

hemoglobin measurement
type: Class
subclass of: Concentration

blood insulin-like growth factor 1 level
type: Class
subclass of: SampleIndicator

parasite count
type: Class
subclass of: Concentration

Sickle Cell Anemia
type: QualityValue
type: Class
subclass of: Medical History
subclass of: Disease
definition: A blood protein disease that is characterized by low number of red blood cells, repeated infections, and periodic episodes of pain, resulting from atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.
notation: 122

Cerebral Malaria
type: QualityValue
type: Class
subclass of: Malaria
definition: A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.
notation: 126

Disease
type: Class
subclass of: Medical History
subclass of: Disease

Drinking Water
type: Class
subclass of: Environmental Material
definition: Drinking Water
definition: Drinking water is water which may be consumed by humans with no adverse effects on their health.

Waist
type: Class
subclass of: BiologicalEntity
definition: The waist is the part of the abdomen between the rib cage and hips. On people with slim bodies, the waist is the narrowest part of the torso.

GO_0016265
deprecated: true

Seizures
type: QualityValue
type: Class
subclass of: Phenotype
definition: Seizures are an intermittent abnormality of the central nervous system due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements. The term epilepsy is used to describe chronic, recurrent seizures.
notation: 125

Coma
type: QualityValue
type: Class
subclass of: Phenotype
definition: Complete absence of wakefulness and content of conscience, which manifests itself as a lack of response to any kind of external stimuli.
notation: 124

Obese
type: QualityValue
type: Class
subclass of: Restriction
  on property: isAttributeOf
  some values from: Restriction
    on property: hasAttribute
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        on property: STATO_0000129
        some values from: Datatype
subclass of: Body Weight Quality
notation: 63

Fever
type: QualityValue
type: Class
subclass of: Phenotype
definition: Elevated body temperature due to failed thermoregulation.
notation: 123

Increased Body Weight
type: QualityValue
type: Class
subclass of: Restriction
  on property: isAttributeOf
  some values from: Restriction
    on property: hasAttribute
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        on property: STATO_0000129
        some values from: Datatype
subclass of: Body Weight Quality
definition: BMI > 25
notation: 72

Overweight
type: QualityValue
type: Class
subclass of: Restriction
  on property: isAttributeOf
  some values from: Restriction
    on property: hasAttribute
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        on property: STATO_0000129
        some values from: Datatype
subclass of: Body Weight Quality
notation: 71

Underweight
type: QualityValue
type: Class
subclass of: Restriction
  on property: isAttributeOf
  some values from: Restriction
    on property: hasAttribute
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        on property: STATO_0000129
        some values from: Datatype
subclass of: Body Weight Quality
subclass of: Underweight/Normal
definition: BMI < 18.5
notation: 99

mass-to-charge ratio
type: UnitOfMeasurement
notation: Th

Teenager
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Demographic
subclass of: Developmental Quality
definition: An individual between the ages of 13 and 19.
notation: 137

African American
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Race
definition: A person having origins in any of the Black racial groups of Africa. Terms such as "Haitian" or "Negro" can be used in addition to "Black or African American".
notation: 8

Hispanic or Latino Ethnicity
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Ethnicity
definition: A person of Cuban, Mexican, Puerto Rican, South or Central American, or other Spanish culture or origin, regardless of race. The term “Spanish origin” can also be used in addition to “Hispanic or Latino.”
notation: 47

Native Hawaiian or Other Pacific Islander
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Race
definition: A person having origins in any of the original peoples of Hawaii, Guam, Samoa, or other Pacific Islands.
notation: 55

American Indian Or AlaskanNative
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Race
definition: A person having origins in any of the original peoples of North and South America (including Central America) and who maintains tribal affiliation or community attachment.
notation: 5

Asian
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Race
definition: A person having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent, including for example, Cambodia, China, India, Japan, Korea, Malaysia, Pakistan, the Philippine Islands, Thailand, and Vietnam.
notation: 6

White
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Race
definition: A person having origins in any of the original peoples of Europe, the Middle East, or North Africa.
notation: 102

Widowed
type: QualityValue
type: Class
subclass of: Unmarried
definition: Indicates a person who is no longer married because of the death of his/her spouse and has not remarried.
notation: 39

Divorced
type: QualityValue
type: Class
subclass of: Unmarried
definition: Indicates a person whose marriage has been legally dissolved and has not remarried.
notation: 40

Separated
type: QualityValue
type: Class
subclass of: Married
definition: Indicates a person living apart from his/her spouse by legal arrangement.
notation: 41

Full Time Employment
type: QualityValue
type: Class
subclass of: Occupation
definition: Employed for a standard number of hours of working time, at least 50% or 20 hours per week.
notation: 64

Domestic Partnership
type: QualityValue
type: Class
subclass of: Unmarried
definition: Indicates a person who is a member of an unmarried couple, including same sex couples, living together in longstanding relationships, that are registered or unregistered.
notation: 42

Multiracial
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Race
definition: Having ancestors of several or various races.
editorial note: Not part of current prov for Race. Should we remove this concept?
notation: 54

Some College
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: C0424933
definition: Indicates that a person has attended college but that they did not receive any degree.
notation: 85

Household Income
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Socioeconomic Status
subclass of: Quantity
definition: A demographic parameter indicating the amount of earnings made by a family.

Homemaker
type: QualityValue
type: Class
subclass of: Occupation
definition: A person who manages a home as their main daily activity.
notation: 68

Student
type: QualityValue
type: Class
subclass of: Occupation
notation: 66

Part Time Employment
type: QualityValue
type: Class
subclass of: Occupation
definition: Employment involving less than the standard or customary working time.
notation: 65

Unemployment
type: QualityValue
type: Class
subclass of: Occupation
definition: The state of not having a job.
notation: 67

Annulled
type: QualityValue
type: Class
subclass of: Never Married
definition: A marital status in which a voidable marriage is legally declared null and void, as though it never existed. Specific grounds for annullment vary within the presiding jurisdiction, whether geographic or religious.
notation: 43

Interlocutory Marital Status
type: QualityValue
type: Class
subclass of: Marital Status
definition: The condition existing when an order or judgement is considered temporary until either a specified period of time has passed or specific information is provided to assist in rendering a permanent decision.
notation: 44

Polygamous
type: QualityValue
type: Class
subclass of: Marital Status
definition: A type of living arrangement or mating system in which at least one member of a relationship has more than one mate.
notation: 45

Childhood
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Demographic
subclass of: Developmental Quality
definition: A time period that begins at the beginning of the human embryonic stage and continues until the end of adolescence.
notation: 11

Hospitalization
type: QualityValue
type: Class
subclass of: Hospital Utilization
subclass of: MedicalProcedure
definition: Admission to a hospital
notation: 104

SO_0000000
deprecated: true

Matched Pair of Subjects
type: Class
subclass of: Collection
definition: A set of 2 subjects which result from a pairing process which assigns subject to a set based on a pairing rule/criteria

Pathogen Transmission
subclass of: Process

Head
type: Class
subclass of: BiologicalEntity

Abdomen
type: Class
subclass of: BiologicalEntity

Retina
type: Class
subclass of: Organ
definition: The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.

Tibia
type: Class
subclass of: BiologicalEntity
definition: The major preaxial endochondral bone in the posterior zeugopod.

Nervous System
type: Class
subclass of: Organ
definition: The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior

Hair
type: Class
subclass of: Tissue
definition: A filament, mostly protein, that grows from follicles found in the dermis[WP]. [database_cross_reference: http://en.wikipedia.org/wiki/Hair]

Urine
type: Class
subclass of: Bodily Fluid
definition: Excretion that is the output of a kidney [database_cross_reference: http://en.wikipedia.org/wiki/Urine][database_cross_reference: https://github.com/geneontology/go-ontology/issues/11025]

Tooth
type: Class
subclass of: Tissue
definition: Skeletal element within the mouth (or in some species, upper part of the digestive tract) that is composed of dentine and is used in procuring or masticating food. [database_cross_reference: http://orcid.org/0000-0002-6601-2165][database_cross_reference: http://en.wikipedia.org/wiki/Tooth_(animal)]

Cerebrospinal fluid
type: Class
subclass of: BiologicalEntity
definition: A clear, colorless fluid that is found in the brain and spinal cord.

Saliva
type: Class
subclass of: Bodily Fluid
definition: A fluid produced in the oral cavity by salivary glands, typically used in predigestion, but also in other functions. [database_cross_reference: http://en.wikipedia.org/wiki/Saliva][database_cross_reference: GO:0046541]

Plasma
type: Class
subclass of: Blood Component
definition: The liquid component of blood, in which erythrocytes are suspended. [database_cross_reference: http://orcid.org/0000-0002-6601-2165]

Serum
type: Class
subclass of: Blood Component
definition: Liquid derived from blood plasma that has clotting factors removed. [database_cross_reference: http://en.wikipedia.org/wiki/Serum_(blood)][database_cross_reference: http://orcid.org/0000-0002-6601-2165]

Placenta
type: Class
subclass of: Pregnancy Sample
subclass of: Tissue
definition: Organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin[GO]. The fetal portion of the placenta is known as the villous chorion. The maternal portion is known as the decidua basalis. The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell. [database_cross_reference: http://en.wikipedia.org/wiki/Placenta][database_cross_reference: http://www.med.umich.edu/lrc/coursepages/m1/embryology/embryo/06placenta.htm]

Trunk
type: Class
subclass of: BiologicalEntity
definition: Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present.

Patella
type: Class
subclass of: BiologicalEntity
definition: The patella, also known as the knee cap or kneepan, is the largest sesamoid bone in the human body. The primary functional role of the patella is knee extension. The patella has convergently evolved in placental mammals and birds; marsupials have only rudimentary, non-ossified patellae. In more primitive tetrapods, including living amphibians and reptiles, the muscle tendons from the upper leg are attached directly to the tibia, and the patella is not present. See also: fabella.

Femur
type: Class
subclass of: BiologicalEntity

Meconium
type: Class
subclass of: Pregnancy Sample
subclass of: Feces
definition: A dark greenish mass that accumulates in the bowel during fetal life and is discharged shortly after birth. [database_cross_reference: BTO:0000838]

Sputum
type: Class
subclass of: Bodily Fluid
definition: Matter ejected from the lungs, bronchi, and trachea, through the mouth. [database_cross_reference: Dorlands_Medical_Dictionary:MerckSource]

Nail
type: Class
subclass of: Tissue
definition: A nail that is part of a manual digit. [database_cross_reference: OBOL:automatic]

Cord Blood
type: Class
subclass of: Pregnancy Sample
subclass of: Whole Blood
definition: Blood that remains in the placenta and in the attached umbilical cord after childbirth[WP]. [database_cross_reference: http://en.wikipedia.org/wiki/Cord_blood]

UBERON_0036255
deprecated: true

meter
type: UnitOfMeasurement
notation: m

kilogram
type: UnitOfMeasurement
notation: kg

second
type: UnitOfMeasurement
notation: s

ampere
type: UnitOfMeasurement
notation: A

kelvin
type: UnitOfMeasurement
notation: K

mole
type: UnitOfMeasurement
notation: mol

candela
type: UnitOfMeasurement
notation: cd

centimeter
type: UnitOfMeasurement
notation: cm

millimeter
type: UnitOfMeasurement
notation: mm

micrometer
type: UnitOfMeasurement
notation: µm

nanometer
type: UnitOfMeasurement
notation: nm

angstrom
type: UnitOfMeasurement
notation: Ang

picometer
type: UnitOfMeasurement
notation: pm

gram
type: UnitOfMeasurement
notation: g

milligram
type: UnitOfMeasurement
notation: mg

microgram
type: UnitOfMeasurement
notation: µg

nanogram
type: UnitOfMeasurement
notation: ng

picogram
type: UnitOfMeasurement
notation: pg

femtogram
type: UnitOfMeasurement
notation: fg

degree Celsius
type: UnitOfMeasurement
notation: C

millisecond
type: UnitOfMeasurement
notation: ms

microsecond
type: UnitOfMeasurement
notation: µs

picosecond
type: UnitOfMeasurement
notation: ps

minute
type: UnitOfMeasurement
notation: min

hour
type: UnitOfMeasurement
notation: h

milliampere
type: UnitOfMeasurement
notation: mA

microampere
type: UnitOfMeasurement
notation: µA

micromole
type: UnitOfMeasurement
notation: µmol

millimole
type: UnitOfMeasurement
notation: mmol

nanomole
type: UnitOfMeasurement
notation: nmol

picomole
type: UnitOfMeasurement
notation: pmol

femtomole
type: UnitOfMeasurement
notation: fmol

attomole
type: UnitOfMeasurement
notation: amol

mass density unit
type: UnitOfMeasurement
notation: mdu

area density unit
type: UnitOfMeasurement
notation: adu

molar
type: UnitOfMeasurement
notation: M

millimolar
type: UnitOfMeasurement
notation: mM

micromolar
type: UnitOfMeasurement
notation: µM

nanomolar
type: UnitOfMeasurement
notation: nM

picomolar
type: UnitOfMeasurement
notation: pM

molal
type: UnitOfMeasurement
notation: mol/kg

millimolal
type: UnitOfMeasurement
notation: mmol/kg

micromolal
type: UnitOfMeasurement
notation: µmol/kg

nanomolal
type: UnitOfMeasurement
notation: nmolal

picomolal
type: UnitOfMeasurement
notation: pmolal

femtomolar
type: UnitOfMeasurement
notation: fM

normal
type: UnitOfMeasurement
notation: Norm

mole fraction
type: UnitOfMeasurement
notation: chi

meter per second per second
type: UnitOfMeasurement
notation: m/s2

radian per second per second
type: UnitOfMeasurement
notation: alpha

radian per second
type: UnitOfMeasurement
notation: rad/s

square meter
type: UnitOfMeasurement
notation: m2

square centimeter
type: UnitOfMeasurement
notation: cm2

square millimeter
type: UnitOfMeasurement
notation: mm2

kilogram per cubic meter
type: UnitOfMeasurement
notation: kg/m3

gram per cubic centimeter
type: UnitOfMeasurement
notation: g/cm3

candela per square meter
type: UnitOfMeasurement
notation: cd/m2

kilogram per square meter
type: UnitOfMeasurement
notation: kg/m2

kilogram per mole
type: UnitOfMeasurement
notation: kg/mol

gram per mole
type: UnitOfMeasurement
notation: g/mol

cubic meter per mole
type: UnitOfMeasurement
notation: m3/mol

cubic centimeter per mole
type: UnitOfMeasurement
notation: cm3/mol

kilogram meter per second
type: UnitOfMeasurement
notation: kg.m/s

turns per second
type: UnitOfMeasurement
notation: 1/s

cubic meter per kilogram
type: UnitOfMeasurement
notation: m3/kg

meter per second
type: UnitOfMeasurement
notation: m/s

cubic meter
type: UnitOfMeasurement
notation: m3

cubic centimeter
type: UnitOfMeasurement
notation: cm3

milliliter
type: UnitOfMeasurement
notation: ml

liter
type: UnitOfMeasurement
notation: L

cubic decimeter
type: UnitOfMeasurement
notation: dm3

microliter
type: UnitOfMeasurement
notation: µl

nanoliter
type: UnitOfMeasurement
notation: nl

picoliter
type: UnitOfMeasurement
notation: pl

femtoliter
type: UnitOfMeasurement
notation: fl

hertz
type: UnitOfMeasurement
notation: Hz

newton
type: UnitOfMeasurement
notation: Ntn

pascal
type: UnitOfMeasurement
notation: Pa

joule
type: UnitOfMeasurement
notation: J

watt
type: UnitOfMeasurement
notation: watt

lux
type: UnitOfMeasurement
notation: lx

lumen
type: UnitOfMeasurement
notation: lm

katal
type: UnitOfMeasurement
notation: kat

radian
type: UnitOfMeasurement
notation: rad

steradian
type: UnitOfMeasurement
notation: sr

becquerel
type: UnitOfMeasurement
notation: Bq

curie
type: UnitOfMeasurement
notation: Ci

Gray
type: UnitOfMeasurement
notation: Gy

roentgen
type: UnitOfMeasurement
notation: Roentgen

sievert
type: UnitOfMeasurement
notation: Sv

millisievert
type: UnitOfMeasurement
notation: mSv

microsievert
type: UnitOfMeasurement
notation: µSv

Roentgen equivalent man
type: UnitOfMeasurement
notation: rem

microgray
type: UnitOfMeasurement
notation: µGy

milligray
type: UnitOfMeasurement
notation: mGy

nanogray
type: UnitOfMeasurement
notation: nGy

nanosievert
type: UnitOfMeasurement
notation: nSv

millicurie
type: UnitOfMeasurement
notation: mCi

microcurie
type: UnitOfMeasurement
notation: µCi

disintegrations per minute
type: UnitOfMeasurement
notation: dpm

counts per minute
type: UnitOfMeasurement
notation: cpm

nanosecond
type: UnitOfMeasurement
notation: ns

foot candle
type: UnitOfMeasurement
notation: ft-c

watt per square meter
type: UnitOfMeasurement
notation: W/m2

einstein per square meter per second
type: UnitOfMeasurement
notation: einstein/sm2

watt per steradian per square meter
type: UnitOfMeasurement
notation: W/sr/m2

microeinstein per square meter per second
type: UnitOfMeasurement
notation: µeinstein/sm2

watt per steradian
type: UnitOfMeasurement
notation: W/sr

mass percentage
type: UnitOfMeasurement
notation: w/w

mass volume percentage
type: UnitOfMeasurement
notation: (w/v)

volume percentage
type: UnitOfMeasurement
notation: %(v/v)

parts per hundred
type: UnitOfMeasurement
notation: pph

parts per thousand
type: UnitOfMeasurement
notation: ppth

parts per million
type: UnitOfMeasurement
notation: ppm

parts per billion
type: UnitOfMeasurement
notation: ppb

parts per trillion
type: UnitOfMeasurement
notation: ppt

parts per quadrillion
type: UnitOfMeasurement
notation: ppq

gram per milliliter
type: UnitOfMeasurement
notation: g/ml

kilogram per liter
type: UnitOfMeasurement
notation: kg/L

gram per liter
type: UnitOfMeasurement
notation: g/L

milligram per milliliter
type: UnitOfMeasurement
notation: mg/ml

unit per milliliter
type: UnitOfMeasurement
notation: U/ml

unit per liter
type: UnitOfMeasurement
notation: U/l

enzyme unit
type: UnitOfMeasurement
notation: enzyme unit

kilogram per meter
type: UnitOfMeasurement
notation: kg/m

percent
type: UnitOfMeasurement
notation: %

count unit
type: UnitOfMeasurement
notation: count

degree Fahrenheit
type: UnitOfMeasurement
notation: F

liter per kilogram
type: UnitOfMeasurement
notation: l/kg

milliliter per kilogram
type: UnitOfMeasurement
notation: ml/kg

microliter per kilogram
type: UnitOfMeasurement
notation: µl/kg

cells per milliliter
type: UnitOfMeasurement
notation: cells per ml

katal per cubic meter
type: UnitOfMeasurement
notation: kat/m3

katal per liter
type: UnitOfMeasurement
notation: kat/l

milliliter per cubic meter
type: UnitOfMeasurement
notation: ml/m3

milliliter per liter
type: UnitOfMeasurement
notation: ml/l

gram per deciliter
type: UnitOfMeasurement
notation: g/dl

deciliter
type: UnitOfMeasurement
notation: dl

colony forming unit
type: UnitOfMeasurement
notation: cfu

plaque forming unit
type: UnitOfMeasurement
notation: pfu

colony forming unit per milliliter
type: UnitOfMeasurement
notation: cfu/ml

plaque forming unit per milliliter
type: UnitOfMeasurement
notation: pfu/ml

disintegrations per second
type: UnitOfMeasurement
notation: dps

volt
type: UnitOfMeasurement
notation: Volt

dalton
type: UnitOfMeasurement
notation: Da

kilodalton
type: UnitOfMeasurement
notation: kDa

watt-hour
type: UnitOfMeasurement
notation: Wh

weber
type: UnitOfMeasurement
notation: Wb

magnetic flux density unit
type: UnitOfMeasurement
notation: MFDU

tesla
type: UnitOfMeasurement
notation: Tesla

volt-hour
type: UnitOfMeasurement
notation: Vh

kilovolt-hour
type: UnitOfMeasurement
notation: kVh

byte
type: UnitOfMeasurement
notation: Byte

kilobyte
type: UnitOfMeasurement
notation: kB

megabyte
type: UnitOfMeasurement
notation: MB

dots per inch
type: UnitOfMeasurement
notation: dpi

micron pixel
type: UnitOfMeasurement
notation: µm pixel

pixels per inch
type: UnitOfMeasurement
notation: p/in

pixels per millimeter
type: UnitOfMeasurement
notation: p/mm

base pair
type: UnitOfMeasurement
notation: bp

kibibyte
type: UnitOfMeasurement
notation: KiB

mebibyte
type: UnitOfMeasurement
notation: MiB

millivolt
type: UnitOfMeasurement
notation: mV

kilovolt
type: UnitOfMeasurement
notation: kV

microvolt
type: UnitOfMeasurement
notation: µV

nanovolt
type: UnitOfMeasurement
notation: nV

picovolt
type: UnitOfMeasurement
notation: pV

megavolt
type: UnitOfMeasurement
notation: MV

newton per meter
type: UnitOfMeasurement
notation: N/m

dyne per cm
type: UnitOfMeasurement
notation: dyn/cm

pascal second
type: UnitOfMeasurement
notation: Pas

poise
type: UnitOfMeasurement
notation: Poise

decibel
type: UnitOfMeasurement
notation: dB

siemens
type: UnitOfMeasurement
notation: 1/AV

watt per meter kelvin
type: UnitOfMeasurement
notation: W/mK

electronvolt
type: UnitOfMeasurement
notation: eV

electric field strength unit
type: UnitOfMeasurement
notation: Efs

volt per meter
type: UnitOfMeasurement
notation: V/m

absorbance unit
type: UnitOfMeasurement
notation: AU

microliters per minute
type: UnitOfMeasurement
notation: µL/min

millimetres of mercury
type: UnitOfMeasurement
notation: mmHg

milligram per liter
type: UnitOfMeasurement
notation: mg/L

microgram per milliliter
type: UnitOfMeasurement
notation: µg/ml

nanogram per milliliter
type: UnitOfMeasurement
notation: ng/ml

milliunits per milliliter
type: UnitOfMeasurement
notation: mU/ml

count per nanomolar second
type: UnitOfMeasurement
notation: 1/nMs

count per molar second
type: UnitOfMeasurement
notation: 1/Ms

count per nanomolar
type: UnitOfMeasurement
notation: 1/nM

count per molar
type: UnitOfMeasurement
notation: 1/M

microgram per liter
type: UnitOfMeasurement
notation: µg/L

cells per microliter
type: UnitOfMeasurement
notation: cp/µl

formazin nephelometric unit
type: UnitOfMeasurement
notation: FNU

curie per liter
type: UnitOfMeasurement
notation: curie/l

microcurie per milliliter
type: UnitOfMeasurement
notation: µcurie/ml

centiMorgan
type: UnitOfMeasurement
notation: cM

centiRay
type: UnitOfMeasurement
notation: cR

kilobasepair
type: UnitOfMeasurement
notation: kbp

megabasepair
type: UnitOfMeasurement
notation: Mb

gigabasepair
type: UnitOfMeasurement
notation: Gb

gigabyte
type: UnitOfMeasurement
notation: GB

terabyte
type: UnitOfMeasurement
notation: TB

9-hydroxyphenanthrene
type: Class
subclass of: PAH
notation: PHEN9

Arsenocholine
type: Class
subclass of: Arsenic Species
notation: Arsenocholine

mono-isononyl phthalate
type: Class
subclass of: Phthalate
notation: mINP

Monoisopropyl phthalate
type: Class
subclass of: Phthalate
notation: MiPP

mono (2-ethyl-5-oxohexyl) phthalate
type: Class
subclass of: Phthalate
notation: MEOHP

2,4'-DDT
type: Class
subclass of: Organochlorine Compound
notation: OPDDT

mono (5-carboxy-2-ethylpentyl) phthalate (DEHP)
type: Class
subclass of: Phthalate
notation: MCEPP

mono-(2-ethylhexyl) terephthalate
notation: MEHTP

Monocyclohexyl phthalate
type: Class
subclass of: Phthalate
notation: MCHP

mono (2-ethyl-5-hydroxyhexyl) phthalate
type: Class
subclass of: Phthalate
notation: MEHHP

N-Ethyl Perfluorooctane sulfonamido acetic acid
notation: NETFOSAA

Mono-2-(carboxymethyl) hexyl phthalate
type: Class
subclass of: Phthalate
notation: MCMHP

mono-hexyl phthalate
type: Class
subclass of: Phthalate
notation: mHxP

2,3,4,5-Tetrachlorophenol
type: Class
subclass of: Environmental Phenol
definition: PHYSICAL DESCRIPTION: Needles (from petroleum ether, ligroin) or beige solid. (NTP, 1992)
notation: TeCP2345

Nicotine-N-oxide
type: Class
subclass of: Tobacco Metabolite
notation: NICO

4,4'-cyclo-hexylidenebisphenol
notation: BPZ

PCB28
type: Class
subclass of: Polychlorobiphenyl
notation: PCB28

3,4-Dihydroxy-benzoic acid methyl ester
type: Class
subclass of: Environmental Phenol
notation: OHMeP

mono benzyl phthalate (BzBP)
type: Class
subclass of: Phthalate
notation: MBP

cis-4,10,13,16-docosatetraenoic acid
type: Class
subclass of: Fatty Acid
notation: C224N6

Perfluorooctanesulfonate
type: Class
subclass of: PFC
notation: PFDODA

6-hydroxychrysene
type: Class
subclass of: PAH
notation: CHRY6

3-Hydroxypropyl-1-methyl mercapturic acid + 3-Hydroxypropyl-2-methyl mercapturic acid + 3-Hydroxypropyl-3-methyl mercapturic acid
notation: HMPMA

1-hydroxychrysene
type: Class
subclass of: PAH
notation: CHRY1

4-hydroxychrysene
type: Class
subclass of: PAH
notation: CHRY4

Interleukin-8
notation: IL8

2-hydroxychrysene
type: Class
subclass of: PAH
notation: CHRY2

mono (3-carboxypropyl) phthalate (multiple)
type: Class
subclass of: Phthalate
notation: MCPP

2,3,4,6-Tetrachlorophenol
type: Class
subclass of: Environmental Phenol
definition: PHYSICAL DESCRIPTION: Brown flakes or beige solid. Strong odor. (NTP, 1992)
notation: TeCP2346

4,4'-(1-phenylethylidene)bisphenol
notation: BPAP

4,4′-(1,4-Phenylenediisopropylidene)bisphenol
notation: BPP

2,2'-bis(4-hydroxyphenyl)butane
notation: BPB

Bisphenol S
type: Class
subclass of: Environmental Phenol
notation: BPS

Perfluorohexane-1-sulphonic acid
type: Class
subclass of: PFC
notation: PFHxS

Perfluorobutanesulfonic acid
type: Class
subclass of: PFC
notation: PFBS

Perfluoroheptanoic acid
type: Class
subclass of: PFC
notation: PFHPA

1-hydroxynaphthalene
type: Class
subclass of: PAH
notation: NAP1

4,4'-(hexafluoroisopropylidene)-dephenol
notation: BPAF

9-hydroxyfluorene
type: Class
subclass of: PAH
notation: FLUO9

Bisphenol F
type: Class
subclass of: Environmental Phenol
notation: BPF

Protocatechuic acid ethyl ester
type: Class
subclass of: Environmental Phenol
notation: OHEtP

6-chloronicotinic acid
notation: CINA6

Mono-n-octyl phthalate
type: Class
subclass of: Phthalate
notation: MOP

2,2'-dihydroxy-methoxybenzophenone
notation: BP8

2,2',4,4'-tetrahydroxybenzophenone
notation: BP2

Benzophenone-1
type: Class
subclass of: Benzophenone
notation: BP1

2-hydroxynaphthalene
type: Class
subclass of: PAH
notation: NAP2

mono-pentyl phthalate
type: Class
subclass of: Phthalate
notation: mPeP

mono-isobutyl phthalate (DiBP)
type: Class
subclass of: Phthalate
notation: MiBP

4-nitrophenol
notation: PNP

Never Smoked
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Smoking Status
definition: The quality of never smoking in the past.
notation: 56

Alive
type: QualityValue
notation: 131

Attribute
type: Class
subclass of: ScienceIndicator

Biological Sex
type: QualityVariable
type: Class
subclass of: Demographic

Circumference
type: QuantityVariable
type: Class
subclass of: Anthropometry

ControlGroup
type: QualityValue
notation: 135

Dead
type: QualityValue
notation: 132

Decreased
type: QualityValue
notation: 133

DNA
type: Class
subclass of: Macromolecule

Genotype
type: Class
subclass of: Medical History

No Sickle Cell Anemia
type: QualityValue
type: Class
subclass of: Medical History
notation: 138

Hermaphrodite
type: QualityValue
notation: 109

Language
type: QualityVariable
type: Class
subclass of: Acculturation
editorial note: Needs to be rooted in sio

Normal
type: QualityValue
notation: 134

Object
type: Class
subclass of: ScienceIndicator

RNA
type: Class
subclass of: Macromolecule

SignLanguage
type: QualityValue
notation: 107

Specific Gravity
type: QuantityVariable
type: Class
subclass of: SampleIndicator
subclass of: Ratio
definition: Specific gravity is the ratio of the density of a substance to the density of a reference substance; equivalently, it is the ratio of the mass of a substance to the mass of a reference substance for the same given volume. Apparent specific gravity is the ratio of the weight of a volume of the substance to the weight of an equal volume of the reference substance. The reference substance is nearly always water at its densest (4°C) for liquids; for gases it is air at room temperature (21°C). Nonetheless, the temperature and pressure must be specified for both the sample and the reference. Pressure is nearly always 1 atm (101.325 kPa). Temperatures for both sample and reference vary from industry to industry.
editorial note: Why is this here? Maybe it belongs in another list

VerbalLanguage
type: QualityValue
notation: 108

WrittenLanguage
type: QualityValue
notation: 106

Cognitive Entity
type: Class
subclass of: NeurocognitiveAssessent

Behavioral Experimental Paradigm
type: Class
subclass of: NeurocognitiveAssessent

Behavioral Experimental Paradigm Condition
type: Class
subclass of: NeurocognitiveAssessent

Cognitive Task
type: Class
subclass of: NeurocognitiveAssessent

72 kDa type IV collagenase
type: Class
label: Interleukin-33
subclass of: Protein
notation: IL33
notation: MMP2

Haptoglobin
type: Class
subclass of: Protein
notation: HAPTOGLOBIN

Metalloproteinase inhibitor 1
type: Class
subclass of: Protein
notation: TIMP1

Lymphotoxin-alpha
type: Class
subclass of: Protein
notation: TNFB

TNF-alpha
type: Class
label: Tumor necrosis factor
subclass of: Biological Response
subclass of: Protein
definition: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918).
notation: TNFA

Interferon gamma
type: Class
subclass of: Protein
notation: IFNG

Interleukin-1 beta
type: Class
subclass of: Biological Response
subclass of: Protein
definition: Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.
notation: IL1B

C-reactive protein
type: Class
subclass of: Biological Response
subclass of: Protein
definition: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Interstitial collagenase
type: Class
subclass of: Protein
notation: MMP1

Granulocyte-macrophage colony-stimulating factor
type: Class
subclass of: Protein
notation: GMCSF

Interleukin-4
type: Class
subclass of: Protein
notation: IL4

Interleukin-5
type: Class
subclass of: Protein
notation: IL5

Histidine-rich protein PFHRP-II
type: Class
subclass of: Protein

Interleukin-6
type: Class
subclass of: Biological Response
subclass of: Protein
definition: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
notation: IL6

Matrilysin
type: Class
subclass of: Protein
notation: MMP7

Stromelysin-2
type: Class
subclass of: Protein
notation: MMP10

Matrix metalloproteinase-9
type: Class
subclass of: Protein
notation: MMP9

Interleukin-9
type: Class
subclass of: Protein
notation: IL9

Metalloproteinase inhibitor 2
type: Class
subclass of: Protein
notation: TIMP2

Interleukin-10
type: Class
subclass of: Biological Response
subclass of: Protein
definition: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
notation: IL10

Interleukin-12 subunit alpha
type: Class
subclass of: Protein
notation: IL12P70

Interleukin-13
type: Class
subclass of: Protein
notation: IL13

Interleukin-15
type: Class
subclass of: Protein
notation: IL15

Leptin
type: Class
subclass of: Analyte
subclass of: Biological Response
subclass of: Protein
definition: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways.

Fms-related tyrosine kinase 3 ligand
type: Class
subclass of: Protein
notation: FLT3L

Interleukin-2
type: Class
subclass of: Protein
notation: IL2

C-C motif chemokine 20
type: Class
subclass of: Protein
notation: MIP3A

Interleukin-17A
type: Class
subclass of: Protein
notation: IL17A

Interleukin-31
type: Class
subclass of: Protein
notation: IL31

Interferon lambda-2
type: Class
subclass of: Protein
notation: IL28A

Interleukin-27 subunit alpha
type: Class
subclass of: Protein
notation: IL27

Interleukin-17F
type: Class
subclass of: Protein
notation: IL17F

Interleukin-22
type: Class
subclass of: Protein
notation: IL22

Interleukin-25
type: Class
subclass of: Protein
notation: IL17EIL25

Interleukin-21
type: Class
subclass of: Protein
notation: IL21

Interleukin-23 subunit alpha
type: Class
subclass of: Protein
notation: IL23

First Year of the Common Era
type: NamedIndividual

Atomic Fluorescence Spectroscopy Instrument
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: PhysicalInstrument
definition: a type of electromagnetic spectroscopy that analyzes fluorescence from a sample. It involves using a beam of light, usually ultraviolet light, that excites the electrons in molecules of certain compounds and causes them to emit light; typically, but not necessarily, visible light.

Acculturation
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Acculturation explains the process of cultural change and psychological change that results following meeting between cultures. This metaclass contains all classes that measure this process.

Active Smoker
type: QualityValue
type: Class
subclass of: Smoking Status
definition: The quality of actively smoking.
editorial note: How is this different from "smoker'?
notation: 2

Assisted Reproductive Therapy
type: QualityValue
type: Class
subclass of: Pregnancy Characteristic
notation: 7

Canned Food Consumption Frequency
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Diet Quantity
definition: Frequency of Canned Food Consumption.
editorial note: Also want to list this under Environmental Exposures (b/c canned food has chemicals in the lining so sometimes it is used as a proxy)

Delivery Characteristics
type: Class
subclass of: StudyIndicator
definition: Attributes related to the delivery of a child.

Direct Mercury Analyzer
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: PhysicalInstrument
definition: Direct mercury analysis incorporates the following sequence: thermal decomposition, catalytic conversion, amalgamation, and atomic absorption spectrophotometry. Controlled heating stages are implemented to first dry and then thermally decompose a sample introduced into a quartz tube. A continuous flow of oxygen carries the decomposition products through a hot catalyst bed where halogens, nitrogen, and sulfur oxides are trapped. All mercury species are reduced to Hg(0) and are then carried along with reaction gases to a gold amalgamator where the mercury is selectively trapped. All nonmercury vapors and decomposition products are flushed from the system by the continuous flow of gas. The amalgamator is subsequently heated and releases all trapped mercury to the single-beam, fixed-wavelength atomic absorption spectrophotometer. Absorbance is measured at 253.7 nm as a function of mercury content

Education Grade
type: QualityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Education
definition: The highest grade of education achieved

Electrospray Ionization Mass Spectrometry
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: MassSpectrometry
definition: Mass spectrometry using ESI is called electrospray ionization mass spectrometry (ESI-MS) or, less commonly, electrospray mass spectrometry (ES-MS). ESI is a so-called 'soft ionization' technique, since there is very little fragmentation. This can be advantageous in the sense that the molecular ion (or more accurately a pseudo molecular ion) is always observed, however very little structural information can be gained from the simple mass spectrum obtained. This disadvantage can be overcome by coupling ESI with tandem mass spectrometry (ESI-MS/MS). Another important advantage of ESI is that solution-phase information can be retained into the gas-phase.

Elementary School
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Some Elementary School
definition: Finished Elementary School
notation: 15

Exposure Monitoring Instrument
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: PhysicalInstrument
definition: A physical instrument that monitors the environment for chemical exposures.

Fast Food Consumption Frequency
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Diet Quantity
definition: Frequency of Fast Food Consumption.

Fenton Preterm Growth Chart
type: Class
subclass of: LineGraph
definition: A growth chart adusted for gestational age

Fresh Vegetable Consumption Frequency
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Diet Quantity
definition: Frequency of Fresh Vegetable Consumption.

Gas Chromatographer–Mass Spectrometer
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Gas Chromatography Instrument
subclass of: Mass Spectrometer
definition: Gas chromatography–mass spectrometry (GC-MS) is an analytical method that combines the features of gas-chromatography and mass spectrometry to identify different substances within a test sample. Applications of GC-MS include drug detection, fire investigation, environmental analysis, explosives investigation, and identification of unknown samples, including that of material samples obtained from planet Mars during probe missions as early as the 1970s. GC-MS can also be used in airport security to detect substances in luggage or on human beings. Additionally, it can identify trace elements in materials that were previously thought to have disintegrated beyond identification. Like liquid chromatography–mass spectrometry, it allows analysis and detection even of tiny amounts of a substance.

Gas Chromatography Instrument
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Chromatography Instrument
definition: Gas chromatography (GC) is a common type of chromatography used in analytical chemistry for separating and analyzing compounds that can be vaporized without decomposition. Typical uses of GC include testing the purity of a particular substance, or separating the different components of a mixture (the relative amounts of such components can also be determined). In some situations, GC may help in identifying a compound. In preparative chromatography, GC can be used to prepare pure compounds from a mixture.

Gestational Age at Birth
type: Class
subclass of: Gestational Age
equivalent class: Class
  intersection of: Gestational Age
  intersection of: Restriction
    all values from: Birth
    on property: measuredAt
definition: Describes how far along a pregnancy is, usually measured in weeks, as measured at birth.

Hydrogen–Deuterium Exchange Mass Spectrometer
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Mass Spectrometer
definition: Hydrogen–deuterium exchange mass spectrometry can determine the overall deuterium content of molecules which have undergone H/D exchange. Because of the sample preparation required, it is typically considered to provide an accurate measurement of non-exchangeable hydrogen atoms only.

High-Performance Liquid Chromatography-Mass Spectrometry
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: High-Performance Liquid Chromatography
subclass of: Liquid Chromatography–Mass Spectrometer
subclass of: Mass Spectrometer
definition: Liquid chromatography–mass spectrometry (LC-MS) is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS). Coupled chromatography - MS systems are popular in chemical analysis because the individual capabilities of each technique are enhanced synergistically. While liquid chromatography separates mixtures with multiple components, mass spectrometry provides structural identity of the individual components with high molecular specificity and detection sensitivity. This tandem technique can be used to analyze biochemical, organic, and inorganic compounds commonly found in complex samples of environmental and biological origin. Therefore, LC-MS may be applied in a wide range of sectors including biotechnology, environment monitoring, food processing, and pharmaceutical, agrochemical, and cosmetic industries.

Inductively Coupled Plasma Mass Spectrometer
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Mass Spectrometer
definition: A type of mass spectrometry which is capable of detecting metals and several non-metals at concentrations as low as one part in 10^15 (part per quadrillion, ppq) on non-interfered low-background isotopes. This is achieved by ionizing the sample with inductively coupled plasma and then using a mass spectrometer to separate and quantify those ions.

Triple Quadrupole Inductively Coupled Plasma Mass Spectrometer
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Inductively Coupled Plasma Mass Spectrometer
definition: A tandem mass spectrometer consisting of two quadrupole mass analyzers in series, with a (non-mass-resolving) radio frequency (RF)–only quadrupole between them to act as a cell for collision-induced dissociation.

Liquid Chromotography-Mass Spectrometery
type: Class
subclass of: MassSpectrometry

Liquid Chromatography - Tandem Mass Spectrometer
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Liquid Chromatography–Mass Spectrometer
subclass of: Tandem Mass Spectrometer
definition: Liquid chromatography and tandem Mass Spectrometry. MS/MS is the combination of two mass analyzers in one mass spec instrument.

Laboratory Result
type: Class
subclass of: SampleIndicator
definition: A measurement taken on a sample.

Mental Health
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Physical and Mental Assessment
definition: Mental Health Indicator

Methylation Assay
type: Class
subclass of: Assay
definition: An assay that measures the methylation levels of sections of a genome.

Microarray Assay
type: Class
subclass of: Assay
definition: An assay that uses a microarray to perform measurements.

Non-smoker
type: QualityValue
type: Class
subclass of: Smoking Status
definition: Doesn't smoker cigarettes.
notation: 59

Oral Health
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Oral Health Indicator Class

Prenatal Nonsmoker
type: QualityValue
type: Class
subclass of: Non-smoker
definition: Could be a former smoker or a non-smoker, so neither should be encoded as the superclass.
editorial note: Should this be a subClassOf PregnancyCharactistic as well?
notation: 76

Prenatal Smoker
type: QualityValue
type: Class
subclass of: Smoker
definition: The quality of having smoked while being pregnant.
editorial note: Should this be a subClassOf PregnancyCharactistic as well?
notation: 77

Previous Smoker
type: QualityValue
type: Class
subclass of: Smoking Status
definition: The quality of having smoked in the past.
notation: 78

Refractometer
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: PhysicalInstrument
definition: A laboratory or field device for the measurement of an index of refraction (refractometry). The index of refraction is calculated from Snell's law while for mixtures, the index of refraction can be calculated from the composition of the material using several mixing rules such as the Gladstone–Dale relation and Lorentz–Lorenz equation.

Sandwich ELISA
type: Class
subclass of: enzyme-linked immunosorbent assay (ELISA)
definition: Sandwich ELISAs involve attachment of a capture antibody to a solid phase support. Samples containing known or unknown antigen are then added in a matrix or buffer that will minimize attachment to the solid phase. An enzyme-labeled antibody is then added for detection.

Sibling
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Class
    intersection of: Restriction
      all values from: Sibling
      on property: hasRole
    intersection of: Human
  on property: inRelationTo
subclass of: Relative
definition: One of two or more individuals having one or both parents in common. A male sibling is a brother, and a female sibling is a sister. In most societies throughout the world, siblings often grow up together, thereby facilitating the development of strong emotional bonds. The emotional bond between siblings is often complicated and is influenced by factors such as parental treatment, birth order, personality, and personal experiences outside the family. However, there are cases where siblings grow up in separate homes, in different environments.

Small Molecule
type: Class
subclass of: Biomolecule
definition: A small molecule is a low molecular weight (< 900 daltons) organic compound that may help regulate a biological process, with a size on the order of 1 nm. Most drugs are small molecules.

Smoker
type: QualityValue
type: Class
subclass of: Smoking Status
definition: The quality of smoking cigarettes.
notation: 105

Stress Frequency
type: QualityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Mental Health
subclass of: BiologicalQuality
definition: How frequently a person gets stressed.
editorial note: Again, we might want to link this to a specific assessment?

Ultra High Performance Liquid Chromatography Instrument
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: High-Performance Liquid Chromatography
definition: Modern HPLC systems have been improved to work at much higher pressures, and therefore are able to use much smaller particle sizes in the columns (<2 μm). These "Ultra High Performance Liquid Chromatography" systems or UHPLCs can work at up to 120 MPa (17,405 lbf/in^2), or about 1200 atmospheres.

Ultra Performance Liquid Chromatography - Mass Spectrometer
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Mass Spectrometer
subclass of: Ultra High Performance Liquid Chromatography Instrument

Vaginal Birth
type: QualityValue
type: Class
subclass of: Pregnancy Characteristic
subclass of: Route Of Delivery
subclass of: Birthing
definition: Had a birthing occur via the vagina.
editorial note: Again, can we add a delivery class
notation: 24

Lymphocyte
type: Class
subclass of: Leukocyte
definition: A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.

Leukocyte
type: Class
subclass of: Blood Component
definition: An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.

Weight
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Anthropometry
subclass of: Mass
definition: The resulting Force from the interaction between a person's Mass and Gravity.

Malaria
type: QualityValue
type: Class
subclass of: Medical History
subclass of: Disease
definition: A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.
notation: 121

esophageal disease
type: Class
subclass of: Disease

Environmental Material
type: Class
subclass of: SampleIndicator
subclass of: Specimen

Retinopathy
type: QualityValue
type: Class
subclass of: Phenotype
definition: Any noninflammatory disease of the retina. This nonspecific term is retained here because of its wide use in the literature, but if possible new annotations should indicate the precise type of retinal abnormality.
notation: 129

Anemia
type: QualityValue
type: Class
subclass of: Phenotype
definition: A reduction in erythrocytes volume or hemoglobin concentration.
notation: 128

Medication
type: QualityVariable
type: Class
subclass of: Prescription Medication and Dietary Supplements
definition: A drug product that contains one or more active and/or inactive ingredients; it is intended to treat, prevent or alleviate the symptoms of disease. This term does not refer to the individual ingredients that make up the product.
notation: 142

Married
type: QualityValue
type: Class
subclass of: Marital Status
definition: Indicates a person currently joined in a legally binding matrimonial union. Classify common law marriage as married. Includes married couples living together and not living together.
notation: 37

Never Married
type: QualityValue
type: Class
subclass of: Unmarried
definition: Indicates a person who has never been married or whose marriages have been annulled.
notation: 38

Household
type: Class
subclass of: Housing Characteristic
subclass of: Community
definition: A household consists of one or more people who live in the same dwelling and also share meals or living accommodation, and may consist of a single family or some other grouping of people. A single dwelling will be considered to contain multiple households if either meals or living space are not shared. The household is the basic unit of analysis in many social, microeconomic and government models, and is important to the fields of economics and inheritance.

Whole Blood
type: Class
subclass of: Bodily Fluid
definition: A fluid that is composed of blood plasma and erythrocytes. [database_cross_reference: http://orcid.org/0000-0002-6601-2165][database_cross_reference: http://en.wikipedia.org/wiki/Blood][database_cross_reference: https://github.com/obophenotype/uberon/issues/9][database_cross_reference: FMA:9670]

Feces
type: Class
subclass of: Biospecimen
definition: Portion of semisolid bodily waste discharged through the anus[MW,modified] [database_cross_reference: http://en.wikipedia.org/wiki/Feces][database_cross_reference: http://www.merriam-webster.com/dictionary/feces]

Entity
type: Class
subclass of: ScienceIndicator

Height
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Anthropometry
definition: Height

Alcohol Use
type: QualityValue
type: Class
subclass of: Alcohol, Tobacco, and Illicit Drug Use
definition: Uses Alcohol
notation: 83

Ancestor
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Class
    intersection of: Restriction
      all values from: Descendant
      on property: hasRole
    intersection of: Human
  on property: inRelationTo
subclass of: Relative
definition: An ancestor or forebear is a parent or (recursively) the parent of an ancestor (i.e., a grandparent, great-grandparent, great-great-grandparent, and so forth). Ancestor is "any person from whom one is descended. In law the person from whom an estate has been inherited."

Atomic Spectroscopy
type: Class
subclass of: Spectroscopy

Beginning
type: Class
subclass of: Restriction
  has value: 1
  on property: hasValue
subclass of: RelativeTime

Birth
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Beginning
subclass of: FromBirth
subclass of: TimeInterval
definition: The ending of a pregnancy by one or more babies leaving a woman's uterus by vagina passage or c-section.

Chromatography Instrument
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: PhysicalInstrument
definition: Chromatography is a laboratory technique for the separation of a mixture. The mixture is dissolved in a fluid called the mobile phase, which carries it through a structure holding another material called the stationary phase. The various constituents of the mixture travel at different speeds, causing them to separate. The separation is based on differential partitioning between the mobile and stationary phases. Subtle differences in a compound's partition coefficient result in differential retention on the stationary phase and thus affect the separation.

Descendant
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Class
    intersection of: Restriction
      all values from: Ancestor
      on property: hasRole
    intersection of: Human
  on property: inRelationTo
subclass of: Relative
definition: The child of a human, or any grandchild, great-grandchild, and so on.

Diet and Nutrition
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Diet and Nutrition Indicator
editorial note: • [WARNING] SDD_00014: The Attributes: [sio:SpecificGravity] are subclasses of neither hasco:StudyIndicator nor hasco:SampleIndicator .

enzyme-linked immunosorbent assay (ELISA)
type: Class
subclass of: Immunoassay
definition: ELISA is an immunoassay that uses antibodies and color change to identify a substance (Wikipedia)

Element
type: Class
subclass of: Targeted Analyte

Environmental Exposure
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: EnvironmentalExposure Indicator Class
editorial note: may need to refine this name in order to clearly differentiate from environmental exposures measured within CHEAR. Perhaps ExternalEnvironmental Exposure. Ok for now but we may want to discuss.

Healthcare Access
type: Class
subclass of: StudyIndicator
definition: Healthcare Access

Hospital Utilization
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Healthcare Access
definition: Hospital Utilization

Liquid Chromatography–Mass Spectrometer
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Liquid Chromatography Instrument
subclass of: Mass Spectrometer
definition: An analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS). Coupled chromatography - MS systems are popular in chemical analysis because the individual capabilities of each technique are enhanced synergistically. While liquid chromatography separates mixtures with multiple components, mass spectrometry provides structural identity of the individual components with high molecular specificity and detection sensitivity. This tandem technique can be used to analyze biochemical, organic, and inorganic compounds commonly found in complex samples of environmental and biological origin.

Liquid Chromatography Instrument
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Chromatography Instrument
definition: A separation technique in which the mobile phase is a liquid. It can be carried out either in a column or a plane. Present day liquid chromatography that generally utilizes very small packing particles and a relatively high pressure is referred to as high performance liquid chromatography (HPLC).

Macromolecule
type: Class
subclass of: Biomolecule
definition: A very large molecule, such as protein, commonly created by polymerization of smaller subunits (monomers). They are typically composed of thousands of atoms or more. The most common macromolecules in biochemistry are biopolymers (nucleic acids, proteins, carbohydrates and polyphenols) and large non-polymeric molecules (such as lipids and macrocycles).

Microplate Reader
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: PhysicalInstrument
definition: Instruments which are used to detect biological, chemical or physical events of samples in microtiter plates. They are widely used in research, drug discovery, bioassay validation, quality control and manufacturing processes in the pharmaceutical and biotechnological industry and academic organizations. Sample reactions can be assayed in 6-1536 well format microtiter plates. The most common microplate format used in academic research laboratories or clinical diagnostic laboratories is 96-well (8 by 12 matrix) with a typical reaction volume between 100 and 200 µL per well. Higher density microplates (384- or 1536-well microplates) are typically used for screening applications, when throughput (number of samples per day processed) and assay cost per sample become critical parameters, with a typical assay volume between 5 and 50 µL per well. Common detection modes for microplate assays are absorbance, fluorescence intensity, luminescence, time-resolved fluorescence, and fluorescence polarization.

Personal Product Use
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Personal Product Use Indicator Class

Polymerase Chain Reaction
type: Class
subclass of: Assay

Preterm Birth
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Birth Outcome
definition: Preterm birth, also known as premature birth, is the birth of a baby at fewer than 37 weeks gestational age.
notation: 88

Private Insurance or Self Pay
type: QualityValue
type: Class
subclass of: Insurance
notation: 51

Quit Smoking
type: QualityValue
type: Class
subclass of: Previous Smoker
definition: Quit Smoking Cigarettes
notation: 82

Room Count
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Housing Characteristic
subclass of: Count
definition: Total Number of Rooms in the Home

Route Of Delivery
type: QualityVariable
type: Class
subclass of: Delivery Characteristics

Underweight/Normal
type: QualityValue
type: Class
subclass of: Restriction
  on property: isAttributeOf
  some values from: Restriction
    on property: hasAttribute
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        on property: STATO_0000129
        some values from: Datatype
subclass of: Body Weight Quality
notation: 100

Benzophenone
type: Class
subclass of: Targeted Analyte

Parity
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Pregnancy Characteristic
subclass of: Count
definition: The number of time that a viviparous organism has given birth

Z-Score
type: Class
subclass of: Anthropometry
definition: A z-score (also known as z-value, standard score, or normal score) is a measure of the divergence of an individual experimental result from the most probable result, the mean. Z is expressed in terms of the number of standard deviations from the mean value.

Age
type: QuantityVariable
type: Class
subclass of: Demographic

Ethnicity
type: QualityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Demographic
subclass of: BiologicalQuality

Female
type: QualityValue
notation: 110

Male
type: QualityValue
notation: 111

Process
type: Class
subclass of: ScienceIndicator

Alcohol, Tobacco, and Illicit Drug Use
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Alcohol, Tobacco, and Illicit Drug Use Indicator Class

Child
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Class
    intersection of: Restriction
      all values from: Parent
      on property: hasRole
    intersection of: Human
  on property: inRelationTo
subclass of: Descendant
definition: A relationship with a parent (such as sons and daughters of any age).

Developmental Quality
type: QualityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: BiologicalQuality
definition: Refers to which stage of development a person is in.

Diet Quantity
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Diet and Nutrition
subclass of: Quantity
definition: A quantity relating to diet and nutrition.
editorial note: What differentiated diet from nutrition? That is why is this needed since we have the DietAndNutrition Class

eosinophils per high-power field
type: Class
comment: A histological count of the eosinophils in a high-power microscopic field of view, or 0.158 mm^2 (x400).
subclass of: Count

Floor Type
type: QualityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Housing Characteristic
subclass of: MaterialEntity
definition: Type of material that makes up the floor.

Medical Therapy Procedure
type: QualityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Medical History
subclass of: MedicalProcedure
definition: Medical Therapy Procedure to aide in treatment.

Mercury Species
type: Class
subclass of: Targeted Analyte

Non-Biological Relative
type: Class
subclass of: Relative
definition: People that are considered relatives but are not related by blood. This includes relatives by marriage, adoption, or fosterage.

Nucleic Acid Sequencing
type: Class
subclass of: Assay

Parent
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Class
    intersection of: Restriction
      all values from: Child
      on property: hasRole
    intersection of: Human
  on property: inRelationTo
subclass of: Ancestor
definition: A parent is the caretaker of a child (where "child" refers to offspring, not necessarily age). A biological parent is a person whose gamete resulted in a child, a male through the sperm, and a female through the ovum. Parents are first-degree relatives and have 50% genetic meet. A female can also become a parent through surrogacy. Some parents may be adoptive parents, who nurture and raise an offspring, but are not actually biologically related to the child. Orphans without adoptive parents can be raised by their grandparents or other family members.

Pregnancy Sample
type: Class
subclass of: Biospecimen
definition: A sample that is taken at or near pregnancy or birth.

Prescription Medication and Dietary Supplements
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Prescription Medication and Dietary Supplements are forms of medical treatment.

Some Middle School
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: High School or Less
definition: Attended Some Middle School
notation: 90

Tandem Mass Spectrometer
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Mass Spectrometer
definition: Tandem mass spectrometry, also known as MS/MS or MS2, involves multiple steps of mass spectrometry selection, with some form of fragmentation occurring in between the stages. In a tandem mass spectrometer, ions are formed in the ion source and separated by mass-to-charge ratio in the first stage of mass spectrometry (MS1). Ions of a particular mass-to-charge ratio (precursor ions) are selected and fragment ions (product ions) are created by collision-induced dissociation, ion-molecule reaction, photodissociation, or other process. The resulting ions are then separated and detected in a second stage of mass spectrometry (MS2).

Technical School
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Education
definition: Attended a Technical School.
notation: 96

eosinophilic esophagitis
type: Class
subclass of: esophageal disease

Esophagus
type: Class
subclass of: Organ

Concentration
type: QuantityVariable
type: Class
subclass of: Laboratory Result

Gestational Age
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Birth Outcome
subclass of: Age
definition: The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization

High-Performance Liquid Chromatography
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: Liquid Chromatography Instrument
definition: High-performance liquid chromatography (HPLC; formerly referred to as high-pressure liquid chromatography), is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. It relies on pumps to pass a pressurized liquid solvent containing the sample mixture through a column filled with a solid adsorbent material. Each component in the sample interacts slightly differently with the adsorbent material, causing different flow rates for the different components and leading to the separation of the components as they flow out the column.

Insurance
type: QualityVariable
type: Class
subclass of: Healthcare Access
subclass of: Socioeconomic Status

Marital Status
type: QualityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Demographic
subclass of: StatusDescriptor
definition: A person's current conjugal status.

Some Elementary School
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: High School or Less
definition: Attended Some Elementary School
notation: 86

Unmarried
type: QualityValue
type: Class
subclass of: Marital Status
definition: Indicates a person not currently joined in a legally binding matrimonial union.
notation: 46

Tissue
type: Class
subclass of: Biospecimen

Biomolecule
type: Class
subclass of: Biospecimen
definition: A biospecimen that is composed of molecular entities.

Birth Outcome
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Birth Outcomes Indicator Class
editorial note: • [WARNING] SDD_00013: The Dictionary Mapping has the following cells with missing labels: cmo:0001297 .

Bodily Fluid
type: Class
subclass of: Biospecimen
definition: Liquids originating from inside the bodies of living people. They include fluids that are excreted or secreted from the body, and body water that normally is not.

Caesarian Section
type: QualityValue
type: Class
subclass of: Pregnancy Characteristic
subclass of: Route Of Delivery
definition: Caesarian Section Medical Procedure. One-third of pregnancies in the US end in C-Sections.
notation: 20

Socioeconomic Status
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Socioeconomic Status Indicator Class

Clinical Measurement
type: Class
subclass of: Physical and Mental Assessment
definition: A quantitative or qualitative value which is the result of an act of assessing a morphological or physiological state or property in a single individual or sample or a group of individuals or samples, based on direct observation or experimental manipulation.

Occupation
type: QualityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Demographic
subclass of: Socioeconomic Status
subclass of: Role
definition: An individual attribute that is the usual or principal work or business of an individual.

Phenotype
type: Class
subclass of: Medical History

Blood Component
type: Class
subclass of: Bodily Fluid
definition: A derivable component of whole blood.

Anthropometry
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Attributes pertaining to the scientific study of the measurements and proportions of the human body.

Biospecimen
type: Class
subclass of: SampleIndicator
subclass of: Specimen
definition: A biological laboratory specimen held by a biorepository for research. Such a specimen would be taken by sampling so as to be representative of any other specimen taken from the source of the specimen. When biological specimens are stored, ideally they remain equivalent to freshly-collected specimens for the purposes of research.

Body Weight Quality
type: Class
subclass of: Anthropometry
subclass of: Quality
definition: A categorization of body mass relative to the height, as defined using Body Mass Index.

High School or Less
type: QualityValue
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Education
definition: Education Level of High School or Less
notation: 33

Housing Characteristic
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Housing Characteristic Indicator Class

Paraben
type: Class
subclass of: Targeted Analyte

Body Mass Index
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Class
  intersection of: Restriction
    on property: wasDerivedFrom
    some values from: Height
  intersection of: Restriction
    on property: wasDerivedFrom
    some values from: Mass
subclass of: Anthropometry
subclass of: Quantity
definition: A measurement relating body weight to height in an organism; typically calculated as the weight of an individual divided by the height of that individual squared. For quadrupeds, the square of body height is often replaced by the square of body length
editorial note: Should we note that this is derived from height and weight? JS: I think so

Smoking Status
type: QualityVariable
type: Class
subclass of: Alcohol, Tobacco, and Illicit Drug Use
subclass of: StatusDescriptor
definition: An indication of a person's current tobacco and nicotine consumption as well as some indication of smoking history
editorial note: We need to discuss this entire hierarchy.

Analyte
type: Class
subclass of: ChemicalEntity

Arsenic Species
type: Class
subclass of: Targeted Analyte
definition: A molecular entity with arsenic components.

Physical and Mental Assessment
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Physical and Mental Assessments Indicator Class

Conceiving
type: Class
comment: to become pregnant with a child.
subclass of: BiologicalReproduction

Mass Spectrometer
type: Class
was approved by: chear-kb:PER-Jim-McCusker
subclass of: PhysicalInstrument
definition: Mass spectrometry (MS) is an analytical technique that ionizes chemical species and sorts the ions based on their mass-to-charge ratio. In simpler terms, a mass spectrum measures the masses within a sample. Mass spectrometry is used in many different fields and is applied to pure samples as well as complex mixtures.

Relative
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Restriction
  all values from: Class
    intersection of: Restriction
      all values from: Relative
      on property: hasRole
    intersection of: Human
  on property: inRelationTo
subclass of: Demographic
subclass of: Role
definition: Broadly, kinship patterns may be considered to include people related by both descent – i.e. social relations during development – and by marriage. Human kinship relations through marriage are commonly called "affinity" in contrast to the relationships that arise in one's group of origin, which may be called one's descent group. In some cultures, kinship relationships may be considered to extend out to people an individual has economic or political relationships with, or other forms of social connections. Within a culture, some descent groups may be considered to lead back to gods or animal ancestors (totems). This may be conceived of on a more or less literal basis.

Polychlorobiphenyl
type: Class
subclass of: Organochlorine Compound

Race
type: QualityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Demographic
subclass of: BiologicalQuality

Alkyl Phosphate Pesticide Metabolite
type: Class
subclass of: Targeted Analyte

Household Appliance Count
type: QuantityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Housing Characteristic
subclass of: Count
definition: Total number of appliances that can be found in the home.

Education
type: QualityVariable
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Demographic
subclass of: Socioeconomic Status
subclass of: ObjectQuality
definition: The act or process of imparting or acquiring knowledge.

Biological Response
type: Class
subclass of: StudyIndicator
definition: Indicator of biological response to environmental exposure
editorial note: abolic_SDD_v1.xlsx

Medical History
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Medical History Indicator Class

Pregnancy Characteristic
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Pregnancy Characteristic Indicator Class

Cell
type: Class
subclass of: Biospecimen

Tobacco Metabolite
type: Class
subclass of: Targeted Analyte

Polybrominated Diphenyl Ether
type: Class
subclass of: Targeted Analyte

Organochlorine Compound
type: Class
subclass of: Targeted Analyte

PFC
type: Class
subclass of: Targeted Analyte

Targeted Analyte
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: Analyte
subclass of: StudyIndicator
definition: A targeted analyte is one that has been selected by the CHEAR program as a prioritized analyte for CHEAR lab hubs to measure.

Demographic
type: Class
was approved by: chear-kb:PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: Demographics are quantifiable characteristics of a given population.
editorial note: SDD-2016-1431-P01_SG_Dictionary_SDD_v1.xlsx

Fatty Acid
type: Class
subclass of: Targeted Analyte
definition: Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax.

Environmental Phenol
type: Class
subclass of: Targeted Analyte

PAH
type: Class
subclass of: Volatile Organic Compound

Phthalate
type: Class
subclass of: Targeted Analyte

Metal
type: Class
subclass of: Element
definition: For environmental purposes, CHEAR metals are metals and metalliods.

Volatile Organic Compound
type: Class
subclass of: Targeted Analyte

min exclusive: 25

min inclusive: 15

max exclusive: 25

max exclusive: 15

min exclusive: 18.5

max exclusive: 25.0

min exclusive: 29.9

min exclusive: 25.0

min exclusive: 25.0

max exclusive: 29.9

max exclusive: 18.5

max exclusive: 25.0