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Metadata

URI
http://purl.obolibrary.org/obo/aero.owl
Contributor(s)
Alan Ruttenberg
Melanie Courtot
Imports
http://purl.obolibrary.org/obo/aero/OMRE_AEROImport.owl
http://purl.obolibrary.org/obo/aero/external-by-hand.owl
http://purl.obolibrary.org/obo/aero/external.owl
http://purl.obolibrary.org/obo/aero/externalDerived.owl
obo:iao.owl
Ontology RDF
RDF (turtle)

Description

The Adverse Event Reporting Ontology (AERO) is designed to facilitate the representation of adverse event reports and their evaluation in relation to clinical guidelines written by various authorities. We take a realist approach in which findings in reports are information artifacts and are related to instances or types that represent patient, symptoms, diseases, etc. We intend that use of this ontology will result in data that interoperates well with OBO Foundry ontologies as we directly use terms from OBO ontologies wherever appropriate.

The initial domain for this work are reports of adverse events following immunization (AEFIs). We represent the Brighton case definitions as our guidelines, show how findings can be assessed in terms of Brighton criteria and how diagnoses of adverse events with different levels of certainty can be obtained by use of the OWL reasoner.

Table of Contents

  1. Classes
  2. Object Properties
  3. Annotation Properties
  4. Named Individuals
  5. Namespaces
  6. Legend

Overview

Pictures say 1,000 words
Figure 1: Ontology overview

Classes

_SymptomsSignsTermsc # Classes

URI http://purl.obolibrary.org/obo/AERO/_SymptomsSignsTerms
Super-classes bfo:Entityc

diagnosis guidelinec # Classes

URI http://purl.obolibrary.org/obo/AERO_0000001
Super-classes obo:IAO_0000033c
Sub-classes obo:AERO_0000003c

disorder resulting from an AEFI processc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000002
Description

MC, 20110126: class renamed from "adverse event following immunization continuant" following AR suggestion

Super-classes obo:AERO_0000005c

Brighton case definitionc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000003
Description

MC, 20110126: this should be linked to the different adverse events reported. AR suggests using a new relation to appear in BFO2, maybe "ascription"

Super-classes obo:AERO_0000001c
Sub-classes obo:AERO_0000242c
obo:AERO_0000039c

Brighton diagnosis of generalized convulsive seizure as an adverse event following immunization c # Classes

URI http://purl.obolibrary.org/obo/AERO_0000004
Description

20121115, MC: originally "a categorical measurement datum whose instances are used to classify adverse events according to whether or not they have some likelihood of being a seizure and if so, to what degree"

Super-classes obo:AERO_0000208c
Restrictions obo:IAO_0000136 some obo:AERO_0000009c
Sub-classes obo:AERO_0000022c
obo:AERO_0000021c
obo:AERO_0000023c

disorder resulting from an adverse event processc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000005
Description

MC, 20110120: This class was initially labeled "adverse event continuant". After discussion with AR, and due to the fact that the word "event" implicitely refers to a process, we renamed this class.

Sub-classes obo:AERO_0000002c

adverse eventc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000009
Description

I initialy made adverse event a defined class: is_a sign and preceded by administration. However, by doing so, and as the range of preceded by is processual entities, I was implicitely making adverse event a subclass of processual entity, therfore making adverse event rash (a continuant) inconsistent.

Sub-classes obo:AERO_0000010c
obo:AERO_0000066c

adverse event following immunizationc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000010
Super-classes obo:AERO_0000009c

_manifestationsc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000011
Description

temporary placeholder - to be removed This class just helps me group some terms during development of the structure

Super-classes obo:OGMS_0000014c
Sub-classes obo:AERO_0000014c
obo:AERO_0000035c
obo:AERO_0000013c
obo:AERO_0000012c

AEFI idiopathic thrombocytopenic purpura according to Brightonc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000012
Super-classes obo:AERO_0000011c

AEFI encephalitis according to Brightonc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000013
Super-classes obo:AERO_0000011c
Restrictions obo:AERO_0000354op some obo:UBERON_0000955c

motor manifestationc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000014
Super-classes obo:AERO_0000011c
Sub-classes obo:AERO_0000027c
obo:AERO_0000043c
obo:AERO_0000044c
obo:AERO_0000025c
obo:AERO_0000040c
obo:AERO_0000042c
obo:AERO_0000028c
obo:AERO_0000373c

adverse event processc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000015
Description

I included the usage of a device into the definition of adverse event as I am aiming at being inclusive, and cover cases such as those described by MAUDE - Manufacturer and User Facility Device Experience. See for example http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfMAUDE/detail.cfm?mdrfoi__id=1942591 - a patient get fitted with bioprosthetic heart valves and dies within the following 4 months.

Sub-classes obo:AERO_0000016c

adverse event following immunization processc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000016
Super-classes obo:AERO_0000015c

seizure level 1 of certainty according to the Brighton criteriac # Classes

URI http://purl.obolibrary.org/obo/AERO_0000021
Description

MC, 20110126: this needs to be linked to the Brighton guideline defined under directive information entity

Super-classes obo:AERO_0000004c

seizure level 2 of certainty according to the Brighton criteriac # Classes

URI http://purl.obolibrary.org/obo/AERO_0000022
Description

MC, 20110126: this needs to be linked to the Brighton guideline defined under directive information entity

Super-classes obo:AERO_0000004c

seizure level 3 of certainty according to the Brighton criteriac # Classes

URI http://purl.obolibrary.org/obo/AERO_0000023
Description

MC, 20110126: this needs to be linked to the Brighton guideline defined under directive information entity

Super-classes obo:AERO_0000004c

atonic motor manifestation findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000025
Super-classes obo:AERO_0000014c
Sub-classes obo:AERO_0000026c

generalized atonic motor manifestation findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000026
Super-classes obo:AERO_0000025c

clonic motor manifestation findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000027
Super-classes obo:AERO_0000014c

generalized motor manifestation findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000028
Super-classes obo:AERO_0000014c

generalized clonic motor manifestation findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000029

generalized tonic motor manifestation findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000030

generalized tonic-clonic motor manifestation findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000031

AEFI hypotonic-hyporesponsive episode according to Brightonc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000035
Super-classes obo:AERO_0000011c

performing a diagnosis of generalized convulsive seizure according to Brighton guidelinesc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000038
Super-classes obo:AERO_0000207c
Restrictions obo:OBI_0000299 some obo:AERO_0000004c

Brighton case definition of generalized convulsive seizure as an adverse event following immunizationc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000039
Super-classes obo:AERO_0000003c
Restrictions obo:OBI_0000297op some ()

shaking findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000040
Super-classes obo:AERO_0000014c
Sub-classes obo:AERO_0000041c

bilateral shaking findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000041
Super-classes obo:AERO_0000040c

syncope findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000042
Description

MC, 20110126: The Brighton guideline on which this is based needs to be checked. Email correspondance with Brighton: [MC] One thing is unclear to me: Level 1 of diagnostic certainty is defined as "witnessed sudden loss of consciousness AND generalized, tonic, clonic, tonic–clonic, or atonic motor manifestations." A footnote adds: atonic in the absence of: hypotonic hyporesponsive episode (as defined by the Brighton Collaboration), syncope, and myoclonic jerks.

If we define syncope as being a loss of consciousness, how can I have a witnessed sudden loss of consciousness and a generalized atonic motor manifestation in the absence of syncope?

[Brighton] Thank you for your question. You are right, that there is an overlap between the clinical presentation of an atonic seizure and a Syncope. This is also true for HHE. This is the very reasonf or the footnote to alert the user of the definition to this differential diagnosis.

If you are working on a database and only have the clinical criteria vailable, you may have some false positives for the atonic seizure cases, unless you obtain additional information, e.g. that the Syncope was vasovagal or orthostatic, or arrhythmic, etc.

Super-classes obo:AERO_0000014c

myoclonic jerk findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000043
Super-classes obo:AERO_0000014c

tonic motor manifestation findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000044
Super-classes obo:AERO_0000014c
Restrictions obo:AERO_0000125op some (obo:AERO_0000044c and ub751bL417C17c)

loss of consciousness findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000045
Super-classes obo:AERO_0000372c
Sub-classes obo:AERO_0000047c

history of unconsciousnessc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000047
Description

MC, 20110126: AR suggest that "history of consciousness is not a process. definition reads "the sudden loss of consciousness was not observed, but the patient was found unconscious", so maybe updating the label would be better : "unwitnessed loss of consciousness with history of unconsciousness" would help

Super-classes obo:AERO_0000045c
Sub-classes obo:AERO_0000048c

witnessed sudden loss of consciousness findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000048
Super-classes obo:AERO_0000047c

bilateral sitec # Classes

URI http://purl.obolibrary.org/obo/AERO_0000050
Super-classes snap:Sitec
Restrictions obo:BFO_0000086 some ogms:OMRE_0000137c

witness rolec # Classes

URI http://purl.obolibrary.org/obo/AERO_0000055
Super-classes snap:Rolec

adverse side effectc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000066
Description

while in some cases the particular may not be actually caused by the intervention, it is an adverse side effect nonetheless.

Super-classes obo:AERO_0000009c

device malfunctionc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000067
Super-classes span:ProcessualEntityc
Restrictions obo:OBI_0000293 some obo:OBI_0000968c

adverse event reportc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000068
Super-classes obo:IAO_0000088c
Restrictions obo:IAO_0000136 some (obo:AERO_0000009c or obo:AERO_0000067c)
obo:OBI_0000312 some obo:AERO_0000209c

reporting processc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000080
Super-classes span:ProcessualEntityc
Restrictions obo:OBI_0000299 some obo:IAO_0000088c
Sub-classes obo:AERO_0000209c

sudden onsetc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000100
Super-classes obo:OGMS_0000014c

rapid progressionc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000101
Super-classes obo:OGMS_0000014c

respiratory distress diagnosisc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000123
Super-classes obo:OGMS_0000014c

performing a diagnosis according to a Brighton case definitionc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000207
Description
Super-classes obo:OBI_0000988c
Sub-classes obo:AERO_0000038c
obo:AERO_0000243c

Brighton diagnosis resultc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000208
Super-classes obo:OGMS_0000014c
Sub-classes obo:AERO_0000267c
obo:AERO_0000004c

adverse event reporting processc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000209
Super-classes obo:AERO_0000080c
Restrictions obo:OBI_0000299 some obo:AERO_0000068c

clinical diagnosis of uncompensated shockc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000210
Super-classes obo:OGMS_0000014c

dermatologic or mucosal signc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000221

tokenc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000223
Sub-classes obo:AERO_0000224c
obo:AERO_0000230c

respiratory-distress-tokenc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000224
Super-classes obo:AERO_0000223c
Members obo:AERO_0000226
obo:AERO_0000225
obo:AERO_0000228
obo:AERO_0000229
obo:AERO_0000227

uncompensated-shock-tokenc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000230
Super-classes obo:AERO_0000223c
Members obo:AERO_0000231
obo:AERO_0000233
obo:AERO_0000232
obo:AERO_0000234

Brighton case definition of anaphylaxis as an adverse event following immunizationc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000242
Super-classes obo:AERO_0000003c

performing a diagnosis of anaphylaxis according to Brighton guidelinesc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000243
Super-classes obo:AERO_0000207c
Restrictions obo:OBI_0000299 some obo:AERO_0000267c

major dermatological criterion for anaphylaxis according to Brightonc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000244
Super-classes obo:AERO_0000248c

generalized urticaria or generalized erythema findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000245
Super-classes obo:OGMS_0000014c
(ub751bL791C22c or ub751bL796C13c)
Restrictions obo:AERO_0000354op some obo:UBERON_0012125c

angioedema findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000246
Description

20130423, MC: in the anaphylaxis case definition, angioedeme can be localized or generalized. There was no need as of today to create specialized subclasses representing those.

Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0012125c
obo:IAO_0000136 some ogms:OMRE_0000105c

generalized pruritus with skin rash findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000247
Super-classes obo:AERO_0000367c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000219c
obo:AERO_0000354op some obo:UBERON_0012125c

_anaphylaxis according to Brighton criteria set of clinical findingsc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000248
Description

20120821, MC: placeholder for development

Super-classes obo:OGMS_0000014c
Sub-classes obo:AERO_0000304c
obo:AERO_0000244c
obo:AERO_0000307c
obo:AERO_0000250c
obo:AERO_0000309c
obo:AERO_0000432c
obo:AERO_0000303c
obo:AERO_0000310c
obo:AERO_0000431c
obo:AERO_0000249c

major cardiovascular criterion for anaphylaxis according to Brightonc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000249
Super-classes obo:AERO_0000248c
Restrictions obo:AERO_0000354op some obo:UBERON_0004535c

major respiratory criterion for anaphylaxis according to Brightonc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000250
Super-classes obo:AERO_0000248c

measured hypotension findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000251
Super-classes obo:OGMS_0000014c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000037c
obo:AERO_0000354op some obo:UBERON_0004535c

uncompensated shock sign findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000252
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0004535c

tachycardia findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000253
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0004535c
obo:IAO_0000136 some ogms:OMRE_0000044c

capillary refill time > 3s findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000254
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0004535c
obo:IAO_0000136 some ogms:OMRE_0000021c
Sub-classes obo:AERO_0000278c

reduced central pulse volume findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000255
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0004535c

decreased level of consciousness or loss of consciousness findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000256
Description

loss of counsciousness is a subclass of decreased consciousness, so saying "is about some decreased level of consciousness" I cover all cases

Restrictions obo:AERO_0000354op some obo:UBERON_0004535c

bilateral wheeze findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000257
Super-classes obo:AERO_0000360c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000114c

stridor findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000258
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0001004c
obo:IAO_0000136 some ogms:OMRE_0000042c

upper airway swelling findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000259
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0001004c
obo:IAO_0000136 some ogms:OMRE_0000116c

tachypnoea findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000260
Super-classes obo:OGMS_0000014c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000045c
obo:AERO_0000354op some obo:UBERON_0001004c

increased use of accessory respiratory muscles findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000261
Super-classes obo:OGMS_0000014c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000031c
obo:AERO_0000354op some obo:UBERON_0001004c

recession findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000262
Super-classes obo:OGMS_0000014c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000355c
obo:AERO_0000354op some obo:UBERON_0001004c

cyanosis findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000263
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0001004c
obo:IAO_0000136 some ogms:OMRE_0000023c

grunting findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000264
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0001004c
obo:IAO_0000136 some ogms:OMRE_0000029c

respiratory distress sign findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000265
Super-classes obo:OGMS_0000014c

Brighton diagnosis of anaphylaxis as an adverse event following immunizationc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000267
Super-classes obo:AERO_0000208c
Sub-classes obo:AERO_0000318c
obo:AERO_0000430c
obo:AERO_0000434c
obo:AERO_0000269c
obo:AERO_0000317c
obo:AERO_0000351c
obo:AERO_0000415c
obo:AERO_0000435c

Level 1 of certainty of anaphylaxis according to Brightonc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000269
Super-classes obo:AERO_0000267c

patientc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000270
Super-classes snap:MaterialEntityc

generalized prickle sensation findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000272
Super-classes obo:AERO_0000365c
Restrictions obo:AERO_0000354op some obo:UBERON_0012125c
obo:IAO_0000136 some ogms:OMRE_0000271c

localized injection site urticaria findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000274
Super-classes obo:AERO_0000370c
Restrictions obo:AERO_0000354op some obo:UBERON_0012125c
obo:IAO_0000136 some ogms:OMRE_0000383c

red and itchy eyes findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000276
Super-classes obo:OGMS_0000014c

reduced peripheral circulation findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000277
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0004535c

capillary refill time > 3s finding without hypotensionc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000278
Super-classes obo:AERO_0000254c
Restrictions obo:AERO_0000354op some obo:UBERON_0004535c

reduced peripheral circulation diagnosisc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000279
Description

The reduced peripheral circulation diagnosis is the minor cardiovascular criterion for anaphylaxis according to Brighton. The diagnosis is established by observing the combination of at least 2 reduced peripheral circulation findings, but at most one of each type.

Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0004535c

generalized pruritus without skin rash findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000281
Super-classes obo:AERO_0000367c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000220c
obo:AERO_0000354op some obo:UBERON_0012125c

persistent dry cough findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000283
Super-classes obo:AERO_0000355c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000027c

hoarse voice findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000285
Super-classes obo:OGMS_0000014c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000030c
obo:AERO_0000354op some obo:UBERON_0001004c

sensation of throat closure findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000290
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0001004c

sneezing or rhinorrhea findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000293
Super-classes obo:OGMS_0000014c

diarrhoea findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000295
Super-classes obo:OGMS_0000014c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000026c
obo:AERO_0000354op some obo:UBERON_0005409c

abdominal pain findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000297
Super-classes obo:OGMS_0000014c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000020c
obo:AERO_0000354op some obo:UBERON_0005409c

nausea findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000299
Super-classes obo:OGMS_0000014c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000038c
obo:AERO_0000354op some obo:UBERON_0005409c

vomiting findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000301
Super-classes obo:OGMS_0000014c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000046c
obo:AERO_0000354op some obo:UBERON_0005409c

mast cell tryptase elevation > upper normal limit findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000302
Super-classes obo:OGMS_0000014c

minor dermatological criterion for anaphylaxis according to Brightonc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000303
Super-classes obo:AERO_0000248c

minor cardiovascular criterion for anaphylaxis according to Brightonc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000304
Super-classes obo:AERO_0000248c

minor respiratory criteria set for anaphylaxis according to Brightonc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000307
Super-classes obo:AERO_0000248c

difficulty breathing without wheeze or stridor findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000308
Super-classes obo:AERO_0000414c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000288c
obo:AERO_0000354op some obo:UBERON_0001004c

minor gastrointestinal criterion for anaphylaxis according to Brightonc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000309
Super-classes obo:AERO_0000248c

minor laboratory criteria set for anaphylaxis according to Brightonc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000310
Super-classes obo:AERO_0000248c

Level 2 of certainty of anaphylaxis according to Brightonc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000317
Super-classes obo:AERO_0000267c

Level 3 of certainty of anaphylaxis according to Brightonc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000318
Super-classes obo:AERO_0000267c

cardiovascular signc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000340

respiratory signc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000341

gastrointestinal signc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000347

Reported anaphylaxis with insufficient evidence to meet the case definitionc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000350
Super-classes obo:AERO_0000415c

not a case of anaphylaxisc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000351
Super-classes obo:AERO_0000267c

dry cough findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000355
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0001004c
Sub-classes obo:AERO_0000283c

chest tightness findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000356
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0001004c
obo:IAO_0000136 some ogms:OMRE_0000022c

indrawing findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000357
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0001004c
obo:IAO_0000136 some ogms:OMRE_0000032c

rhinorrhea findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000358
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0001004c
obo:IAO_0000136 some ogms:OMRE_0000354c

sore throat findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000359
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0001004c
obo:IAO_0000136 some ogms:OMRE_0000040c

wheezing findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000360
Super-classes obo:OGMS_0000014c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000048c
obo:AERO_0000354op some obo:UBERON_0001004c
Sub-classes obo:AERO_0000257c

erythema findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000361
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0012125c
obo:IAO_0000136 some ogms:OMRE_0000205c
Sub-classes obo:AERO_0000362c

generalized erythema findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000362
Super-classes obo:AERO_0000361c
Restrictions obo:AERO_0000354op some obo:UBERON_0012125c
obo:IAO_0000136 some ogms:OMRE_0000104c

red eyes findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000363
Super-classes obo:OGMS_0000014c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000338c
obo:AERO_0000354op some obo:UBERON_0012125c

itchy eyes findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000364
Super-classes obo:OGMS_0000014c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000339c
obo:AERO_0000354op some obo:UBERON_0012125c

prickle sensation findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000365
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0012125c
obo:IAO_0000136 some ogms:OMRE_0000336c
Sub-classes obo:AERO_0000272c

pruritus findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000366
Super-classes obo:OGMS_0000014c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000335c
obo:AERO_0000354op some obo:UBERON_0012125c
Sub-classes obo:AERO_0000367c

generalized pruritus findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000367
Super-classes obo:AERO_0000366c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000107c
obo:AERO_0000354op some obo:UBERON_0012125c
Sub-classes obo:AERO_0000247c
obo:AERO_0000281c

rash findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000368
Super-classes obo:OGMS_0000014c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000337c
obo:AERO_0000354op some obo:UBERON_0012125c
Sub-classes obo:AERO_0000369c

skin rash findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000369
Super-classes obo:AERO_0000368c
Restrictions obo:AERO_0000354op some obo:UBERON_0012125c
obo:IAO_0000136 some ogms:OMRE_0000108c

urticaria findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000370
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0012125c
obo:IAO_0000136 some ogms:OMRE_0000334c
Sub-classes obo:AERO_0000371c
obo:AERO_0000274c

generalized urticaria findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000371
Super-classes obo:AERO_0000370c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000103c
obo:AERO_0000354op some obo:UBERON_0012125c

decreased level of consciousness findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000372
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0004535c
obo:IAO_0000136 some ogms:OMRE_0000024c
Sub-classes obo:AERO_0000045c

tonic-clonic manifestation findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000373
Super-classes obo:AERO_0000014c
Restrictions obo:AERO_0000125op some (obo:AERO_0000027c and ub751bL1955C17c)

sneezing findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000382
Super-classes obo:OGMS_0000014c
Restrictions obo:IAO_0000136 some ogms:OMRE_0000291c

difficulty breathing findingc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000414
Super-classes obo:OGMS_0000014c
Restrictions obo:AERO_0000354op some obo:UBERON_0001004c
Sub-classes obo:AERO_0000308c

reported anaphylaxisc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000415
Super-classes obo:AERO_0000267c
Sub-classes obo:AERO_0000350c

Level 3 of certainty of anaphylaxis - post ICPEc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000430
Description

Following the ICPE meeting in Montreal 2013, MC clarified with JB that the guideline should be understood as "if there is a minor cardiovascular criteria, then we need 2 other systems involved, including respiratory, dermatologic, gastrointestinal and laboratory" and similarly if there is a respiratory criteria. The first iteration was interpreted as (1 minor cardiovascular OR respiratory criterion) AND 2 minors from systems that are neither respiratory nor cardiovascular (dermatologic, gastrointestinal , laboratory systems) to mimic behavior of the ABC tool.

Super-classes obo:AERO_0000267c

minor respiratory criteria set for anaphylaxis according to Brighton - post ICPEc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000431
Description

Following meeting at ICPE Montreal 2013, MC and JB clairfied that "difficulty breathing without wheeze or stridor" should be understood as "difficulty breathing"

Super-classes obo:AERO_0000248c

minor dermatological criterion for anaphylaxis according to Brighton - post ICPEc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000432
Description

Following meeting at ICPE Montreal 2013, MC and JB clairfied that "genralized pruritus withou rash" should be understood as "generalized pruritus"

Super-classes obo:AERO_0000248c

Level 2 of certainty of anaphylaxis according to Brighton - post ICPEc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000434
Super-classes obo:AERO_0000267c

Level 3 of certainty of anaphylaxis - PHAC formc # Classes

URI http://purl.obolibrary.org/obo/AERO_0000435
Description

20130912: In the paper http://dx.doi.org/10.1016/j.vaccine.2010.04.041 "Can the Brighton Collaboration case definitions be used to improve the quality of Adverse Event Following Immunization (AEFI) reporting? Anaphylaxis as a case study", the form used by PHAC and shown in Appendix E states as a footnote "for level III, a skin MAJOR can count as a minor criterion"

Super-classes obo:AERO_0000267c

IAO_0000033c # Classes

URI http://purl.obolibrary.org/obo/IAO_0000033
Sub-classes obo:AERO_0000001c

OBI_0000274c # Classes

URI http://purl.obolibrary.org/obo/OBI_0000274

OBI_0000938c # Classes

URI http://purl.obolibrary.org/obo/OBI_0000938

OBI_0000988c # Classes

URI http://purl.obolibrary.org/obo/OBI_0000988
Restrictions obo:OBI_0000293 some obo:OGMS_0000014c
obo:OBI_0000299 some obo:OBI_0000075c
Sub-classes obo:AERO_0000207c

OBI_0600007c # Classes

URI http://purl.obolibrary.org/obo/OBI_0600007

OGMS_0000014c # Classes

URI http://purl.obolibrary.org/obo/OGMS_0000014
Sub-classes obo:AERO_0000293c
obo:AERO_0000285c
obo:AERO_0000248c
obo:AERO_0000258c
obo:AERO_0000276c
obo:AERO_0000252c
obo:AERO_0000368c
obo:AERO_0000366c
obo:OBI_0000075c
obo:AERO_0000246c
obo:AERO_0000302c
obo:AERO_0000356c
obo:AERO_0000358c
obo:AERO_0000245c
obo:AERO_0000364c
obo:AERO_0000360c
obo:AERO_0000100c
obo:AERO_0000355c
obo:AERO_0000101c
obo:AERO_0000210c
obo:AERO_0000357c
obo:AERO_0000299c
obo:AERO_0000261c
obo:AERO_0000123c
obo:AERO_0000301c
obo:AERO_0000297c
obo:AERO_0000260c
obo:AERO_0000253c
obo:AERO_0000251c
obo:AERO_0000279c
obo:AERO_0000365c
obo:AERO_0000277c
obo:AERO_0000254c
obo:AERO_0000290c
obo:AERO_0000414c
obo:AERO_0000265c
obo:AERO_0000370c
obo:AERO_0000372c
obo:AERO_0000255c
obo:AERO_0000264c
obo:AERO_0000363c
obo:AERO_0000361c
obo:AERO_0000382c
obo:AERO_0000263c
obo:AERO_0000208c
obo:AERO_0000262c
obo:AERO_0000359c
obo:AERO_0000295c
obo:AERO_0000259c
obo:AERO_0000011c
In domain of obo:AERO_0000374op
obo:AERO_0000354op

OGMS_0000045c # Classes

URI http://purl.obolibrary.org/obo/OGMS_0000045

VO_0000002c # Classes

URI http://purl.obolibrary.org/obo/VO_0000002

Entityc # Classes

URI http://www.ifomis.org/bfo/1.1#Entity
Sub-classes AERO:_SymptomsSignsTermsc

MaterialEntityc # Classes

URI http://www.ifomis.org/bfo/1.1/snap#MaterialEntity
Sub-classes obo:AERO_0000270c
In range of obo:AERO_0000354op

Qualityc # Classes

URI http://www.ifomis.org/bfo/1.1/snap#Quality

Rolec # Classes

URI http://www.ifomis.org/bfo/1.1/snap#Role
Sub-classes obo:AERO_0000055c

Sitec # Classes

URI http://www.ifomis.org/bfo/1.1/snap#Site
Sub-classes obo:AERO_0000050c

ProcessualEntityc # Classes

URI http://www.ifomis.org/bfo/1.1/span#ProcessualEntity
Sub-classes obo:AERO_0000067c
obo:AERO_0000080c

Object Properties

found to exhibitop # OPs

URI http://purl.obolibrary.org/obo/AERO_0000088

has componentop # OPs

URI http://purl.obolibrary.org/obo/AERO_0000125
Super-properties ro:has_partop

involvesop # OPs

URI http://purl.obolibrary.org/obo/AERO_0000354
Description

20101115, MC: one difiiculty in defining this relation is how to "cut" the chain at the first system involved. Example (from AR): a patient has a stroke in a nexk artery, which causes brain damage. We would still say "stroke involves cardiovascular system" and NOT "stroke involves nervous system"

Domain(s) obo:OGMS_0000014c
Range(s) snap:MaterialEntityc

is clinical finding aboutop # OPs

URI http://purl.obolibrary.org/obo/AERO_0000374
Super-properties obo:IAO_0000136
Inverse properties obo:AERO_0000088op
Domain(s) obo:OGMS_0000014c

realizesop # OPs

URI http://purl.obolibrary.org/obo/BFO_0000055

begins to exist duringop # OPs

URI http://purl.obolibrary.org/obo/BFO_0000068
Super-properties ro:participates_in

located atop # OPs

URI http://purl.obolibrary.org/obo/BFO_0000083

OBI_0000294op # OPs

URI http://purl.obolibrary.org/obo/OBI_0000294

OBI_0000297op # OPs

URI http://purl.obolibrary.org/obo/OBI_0000297

OBI_0000300op # OPs

URI http://purl.obolibrary.org/obo/OBI_0000300

unfolds_inop # OPs

URI http://purl.org/obo/owl/OBO_REL#unfolds_in

has_partop # OPs

URI http://www.obofoundry.org/ro/ro.owl#has_part

located_inop # OPs

URI http://www.obofoundry.org/ro/ro.owl#located_in

preceded_byop # OPs

URI http://www.obofoundry.org/ro/ro.owl#preceded_by

precedesop # OPs

URI http://www.obofoundry.org/ro/ro.owl#precedes

Annotation Properties

BrightonFormulaap # APs

URI http://purl.obolibrary.org/obo/AERO_0000106

PHAC definitionap # APs

URI http://purl.obolibrary.org/obo/AERO_0000324

IAO_0000115ap # APs

URI http://purl.obolibrary.org/obo/IAO_0000115

IAO_0000118ap # APs

URI http://purl.obolibrary.org/obo/IAO_0000118

IAO_0000119ap # APs

URI http://purl.obolibrary.org/obo/IAO_0000119

commentap # APs

URI http://www.w3.org/2000/01/rdf-schema#comment

labelap # APs

URI http://www.w3.org/2000/01/rdf-schema#label

versionInfoap # APs

URI http://www.w3.org/2002/07/owl#versionInfo

Named Individuals

cynosis-tokenni

Class(es)
obo:AERO_0000224
URI http://purl.obolibrary.org/obo/AERO_0000225

grunting-tokenni

Class(es)
obo:AERO_0000224
URI http://purl.obolibrary.org/obo/AERO_0000226

increased use of accessory respiratory muscles-tokenni

Class(es)
obo:AERO_0000224
URI http://purl.obolibrary.org/obo/AERO_0000227

recession-tokenni

Class(es)
obo:AERO_0000224
URI http://purl.obolibrary.org/obo/AERO_0000228

tachypnoea-tokenni

Class(es)
obo:AERO_0000224
URI http://purl.obolibrary.org/obo/AERO_0000229

tachycardia-tokenni

Class(es)
obo:AERO_0000230
URI http://purl.obolibrary.org/obo/AERO_0000231

capillary refill time above 3s-tokenni

Class(es)
obo:AERO_0000230
URI http://purl.obolibrary.org/obo/AERO_0000232

reduced central pulse volume-tokenni

Class(es)
obo:AERO_0000230
URI http://purl.obolibrary.org/obo/AERO_0000233

decreased level of consciousness or loss of consciousness-tokenni

Class(es)
obo:AERO_0000230
URI http://purl.obolibrary.org/obo/AERO_0000234

Namespaces

default (:)
http://purl.obolibrary.org/obo/aero.owl
AERO
http://purl.obolibrary.org/obo/AERO/
GO
http://purl.org/obo/owl/GO#
OBO_REL
http://purl.org/obo/owl/OBO_REL#
bfo
http://www.ifomis.org/bfo/1.1#
dc
http://purl.org/dc/elements/1.1/
dct
http://purl.org/dc/terms/
obo
http://purl.obolibrary.org/obo/
oboInOwl
http://www.geneontology.org/formats/oboInOwl#
ogms
http://purl.obolibrary.org/obo/ogms/
owl
http://www.w3.org/2002/07/owl#
prov
http://www.w3.org/ns/prov#
rdf
http://www.w3.org/1999/02/22-rdf-syntax-ns#
rdfs
http://www.w3.org/2000/01/rdf-schema#
ro
http://www.obofoundry.org/ro/ro.owl#
sdo
https://schema.org/
skos
http://www.w3.org/2004/02/skos/core#
snap
http://www.ifomis.org/bfo/1.1/snap#
span
http://www.ifomis.org/bfo/1.1/span#
xsd
http://www.w3.org/2001/XMLSchema#

Legend

cClasses
opObject Properties
fpFunctional Properties
dpData Properties
dpAnnotation Properties
pProperties
niNamed Individuals