@prefix rdf: . @prefix : . @prefix cl: . @prefix dc: . @prefix go: . @prefix pr: . @prefix obo: . @prefix owl: . @prefix xml: . @prefix xsd: . @prefix core: . @prefix foaf: . @prefix pato: . @prefix rdfs: . @prefix skos: . @prefix sssom: . @prefix terms: . @prefix uberon: . @prefix ubprop: . @prefix subsets: . @prefix oboInOwl: . @prefix ncbitaxon: . @prefix CCN20230722: . obo:BFO_0000002 a owl:Class . obo:BFO_0000050 a owl:ObjectProperty . obo:BFO_0000051 a owl:ObjectProperty . obo:CLM_0010001 a owl:AnnotationProperty . obo:CLM_0010002 a owl:AnnotationProperty . obo:CLM_0010003 a owl:AnnotationProperty . obo:CLM_1000001 a owl:Class . obo:CLM_1000002 a owl:Class . obo:CLM_1000003 a owl:Class . obo:CLM_1000004 a owl:Class . obo:CLM_1000005 a owl:Class . obo:CLM_1000006 a owl:Class . obo:CLM_1000008 a owl:Class . obo:CLM_1000009 a owl:Class . obo:CLM_1000010 a owl:Class . obo:CLM_1000026 a owl:Class . obo:CLM_1000027 a owl:Class . obo:CLM_1000031 a owl:Class . obo:CLM_1000032 a owl:Class . obo:CLM_1000041 a owl:Class . obo:CLM_1000043 a owl:Class . obo:CLM_1000046 a owl:Class . obo:CLM_1000047 a owl:Class . obo:CLM_1000052 a owl:Class . obo:CLM_1000053 a owl:Class . obo:CLM_1000054 a owl:Class . obo:CLM_1000056 a owl:Class . obo:CLM_1000059 a owl:Class . obo:CLM_1000061 a owl:Class . obo:CLM_1000063 a owl:Class . obo:CLM_1000065 a owl:Class . obo:CLM_1000066 a owl:Class . obo:CLM_1000067 a owl:Class . obo:CLM_1000068 a owl:Class . obo:CLM_1000069 a owl:Class . obo:CLM_1000070 a owl:Class . obo:CLM_1000071 a owl:Class . obo:CLM_1000072 a owl:Class . obo:CLM_1000073 a owl:Class . obo:CLM_1000074 a owl:Class . obo:CLM_1000075 a owl:Class . obo:CLM_1000079 a owl:Class . obo:CLM_1000080 a owl:Class . obo:CLM_1000081 a owl:Class . obo:CLM_1000082 a owl:Class . obo:CLM_1000083 a owl:Class . obo:CLM_1000085 a owl:Class . obo:CL_0000000 obo:IAO_0000115 "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." ; oboInOwl:hasDbXref "CALOHA:TS-2035", "FBbt:00007002", "FMA:68646", "GO:0005623", "KUPO:0000002", "MESH:D002477", "VHOG:0001533", "WBbt:0004017", "XAO:0003012", "ZFA:0009000" ; oboInOwl:inSubset cl:cellxgene_subset, ubprop:_upper_level ; a owl:Class ; rdfs:comment "The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one)." ; rdfs:label "cell" ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_131567 ] ; owl:disjointWith obo:GO_0031012, obo:GO_0032991, obo:GO_0043226, obo:GO_0044423 ; skos:prefLabel "cell" . obo:CL_0000001 obo:IAO_0000115 "A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged." ; oboInOwl:hasDbXref "BTO:0002290" ; oboInOwl:hasExactSynonym "primary cell culture cell", "unpassaged cultured cell" ; oboInOwl:hasRelatedSynonym "primary cell line cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Covers cells actively being cultured or stored in a quiescent state for future use." ; rdfs:label "primary cultured cell" ; rdfs:subClassOf obo:CL_0000010 . obo:CL_0000002 obo:IAO_0000115 "OBSOLETE: A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite growth/propagation in vitro as part of a immortal cell line." ; obo:IAO_0100001 obo:CLO_0000019 ; oboInOwl:hasExactSynonym "continuous cell line cell", "permanent cell line cell" ; a owl:Class ; rdfs:comment """Obsoleted in July 2013 and replaced by the CLO 'immortal cell line cell' class, as a result of CLO-OBI-CL alignment efforts. Covers cells actively being cultured or stored in a quiescent state for future use.""" ; rdfs:label "obsolete immortal cell line cell" ; owl:deprecated true . obo:CL_0000003 obo:IAO_0000115 "OBSOLETE. A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment)." ; obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000000 ; oboInOwl:hasDbXref "CARO:0000013" ; oboInOwl:hasNarrowSynonym "cell in vivo" ; oboInOwl:inSubset ubprop:_upper_level ; a owl:Class ; rdfs:label "obsolete native cell" ; owl:deprecated true . obo:CL_0000004 obo:IAO_0000115 "OBSOLETE: A classification of cells by the organisms within which they are contained." ; oboInOwl:consider "CL:0000000", "CL:0000003", "CL:0001034" ; a owl:Class ; rdfs:comment "This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its species. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate." ; rdfs:label "obsolete cell by organism" ; owl:deprecated true . obo:CL_0000005 obo:IAO_0000115 "Any fibroblast that is derived from the neural crest." ; oboInOwl:hasExactSynonym "fibroblast neural crest derived" ; a owl:Class ; rdfs:label "neural crest derived fibroblast" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000008 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] ) ] . obo:CL_0000006 obo:IAO_0000115 "Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception." ; oboInOwl:hasDbXref "ZFA:0009001" ; oboInOwl:hasExactSynonym "neuronal receptor cell (sensu Animalia)" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "neuronal receptor cell" ; rdfs:subClassOf obo:CL_0000101, obo:CL_0000197 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000197 obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050906 ] ) ] ; skos:prefLabel "neuronal receptor cell" . obo:CL_0000007 obo:IAO_0000115 "A cell found in the embryo before the formation of all the gem layers is complete." ; oboInOwl:hasDbXref "ZFA:0009002" ; a owl:Class ; rdfs:label "early embryonic cell (metazoa)" ; rdfs:subClassOf obo:CL_0002321 ; skos:prefLabel "early embryonic cell (metazoa)" . obo:CL_0000008 obo:IAO_0000115 "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination." ; oboInOwl:hasDbXref "ZFA:0007091" ; a owl:Class ; rdfs:label "migratory cranial neural crest cell" ; rdfs:subClassOf obo:CL_0000333 ; skos:prefLabel "migratory cranial neural crest cell" . obo:CL_0000009 obo:IAO_0000115 "Obsolete. Use PO:0000079 from Plant Ontology instead. An elongated cell with approximately wedge-shaped ends, found in the vascular cambium, which gives rise to the elements of the axial system in the secondary vascular tissues." ; obo:IAO_0100001 obo:PO_0000079 ; oboInOwl:hasRelatedSynonym "xylem initial", "xylem mother cell" ; a owl:Class ; rdfs:label "obsolete fusiform initial" ; owl:deprecated true . obo:CL_0000010 obo:IAO_0000115 "A cell in vitro that is or has been maintained or propagated as part of a cell culture." ; oboInOwl:hasDbXref "MESH:D002478" ; a owl:Class ; rdfs:comment "Note that this class was re-labeled to 'cultured cell' instead of 'cell line cell', as it intent was clarified to cover any cultured cells of multicellular and unicellular organisms. This includes cells actively being cultured, or cells that have been cultured but are stored in a quiescent state for future use. In having been cultured, cells must establish homeostasis and often replicate in a foreign environment. Accomodation of this stress initiates a selection of cells fit for such challenges, wherein necessary adaptive biochemical and.or genetic changes can occur. These changes can set them apart from the in vivo cells from which they derive, and such changes will typically accumulate and change over increasing time in culture." ; rdfs:label "cultured cell" ; rdfs:subClassOf obo:CL_0000578 . obo:CL_0000011 obo:IAO_0000115 "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination." ; oboInOwl:hasDbXref "ZFA:0007095" ; a owl:Class ; rdfs:label "migratory trunk neural crest cell" ; rdfs:subClassOf obo:CL_0000333 . obo:CL_0000012 oboInOwl:consider "CL:0000000", "CL:0000003", "CL:0001034" ; a owl:Class ; rdfs:comment "This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate." ; rdfs:label "obsolete cell by class" ; owl:deprecated true . obo:CL_0000013 oboInOwl:consider "CL:0000140" ; a owl:Class ; rdfs:label "obsolete dentine secreting cell" ; owl:deprecated true . obo:CL_0000014 obo:IAO_0000115 "A stem cell that is the precursor of gametes." ; oboInOwl:hasDbXref "FBbt:00004861", "ZFA:0005956" ; oboInOwl:hasExactSynonym "germline stem cell" ; a owl:Class ; rdfs:label "germ line stem cell" ; rdfs:subClassOf obo:CL_0000034, obo:CL_0000039 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000039 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0017145 ] ) ] . obo:CL_0000015 obo:IAO_0000115 "A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis." ; terms:description """Male germ cells are specialized cells that give rise to the male gametes and are therefore crucial for sexual reproduction in males. Through a complex process called spermatogenesis in the testes male germ cells undergo several stages of development, each with distinctive morphological and physiological characteristics, eventually differentiating into mature spermatozoa (sperm). Male germ cells are responsible for transferring genetic material from male to offspring as part of sexual reproduction. In the initial stage of their life cycle, they exist as spermatogonial stem cells, which multiply by mitotic division to self-renew and to produce daughter cells. The daughter cells then undergo meiotic division, a process that reduces the number of chromosomes in each cell by half, from diploid to haploid – the formation of spermatids. This is critical for maintaining genetic stability from generation to generation, as it ensures that when an egg and sperm cell unite during fertilization, the resulting offspring will have the correct number of chromosomes. The final phase of spermatogenesis is called spermiogenesis, during which spermatozoa - mature and motile sperm cells – are produced from round spermatids. The matured male germ cells or sperm cells are highly specialized, having a streamlined shape designed for efficient movement towards the female egg. A sperm cell is divided into three main parts, namely the head, midpiece, and tail. The head contains the genetic material, the midpiece contains mitochondria that provide energy, and the tail, termed as the flagellum, propels the sperm cell forward. Each of these parts play significant roles in fertilization. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:72290", "MA:0002765", "VHOG:0001531", "ncithesaurus:Spermatogenic_Cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "male germ cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000015", "https://github.com/obophenotype/cell-ontology/issues/574" ; rdfs:subClassOf obo:CL_0000586, [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007283 ] . obo:CL_0000016 obo:IAO_0000115 "A stem cell that is the precursor of male gametes." ; oboInOwl:hasDbXref "FBbt:00004929" ; a owl:Class ; rdfs:label "male germ line stem cell" ; rdfs:subClassOf obo:CL_0000014, obo:CL_0000015 . obo:CL_0000017 obo:IAO_0000115 "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." ; oboInOwl:hasDbXref "BTO:0001275", "CALOHA:TS-0951", "EMAPA:31484", "FBbt:00004936", "FMA:84049", "WBbt:0006799", "ZFA:0009005" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "spermatocyte" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000015, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000020 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048137 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000015 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048137 ] ) ] . obo:CL_0000018 obo:IAO_0000115 "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." ; oboInOwl:hasDbXref "BTO:0001274", "CALOHA:TS-0950", "EMAPA:31486", "FBbt:00004942", "FMA:72294", "WBbt:0006800", "ZFA:0005769" ; oboInOwl:hasExactSynonym "nematoblast" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "spermatid" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000015, obo:CL_0000255, obo:CL_0000413, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000657 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001675 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007288 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007289 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000015 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001375 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001675 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007288 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007289 ] ) ] . obo:CL_0000019 obo:IAO_0000115 "A mature male germ cell that develops from a spermatid." ; terms:description """Sperm cells, also known as spermatozoa or male gametes, are highly specialized cells that are pivotal for sexual reproduction in animals. Produced in the male reproductive organs, specifically the testes, sperm cells play an important role in the process of fertilization, where they fuse with a female gamete or egg cell (ovum) to form a zygote, which marks the beginning of a new organism. Sperm cells hold several unique traits that set them apart from other body cells. Structurally, a sperm cell possesses two main structures: the head, containing the nucleus carrying the paternal genetic information, and the flagellum, which generates energy and grants the sperm cell mobility The process of fertilization occurs when one sperm cell successfully penetrates the egg, delivering its genetic information, and ultimately leading to the formation of a new individual combining both paternal and maternal genetic materials. Notably, while hundreds of millions of sperm cells may be released during ejaculation, only one has the opportunity to successfully fertilize the egg, underscoring the highly competitive nature of this biological process. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:0001277", "BTO:0002046", "CALOHA:TS-0949", "FBbt:00004954", "FMA:67338", "WBbt:0006798", "ZFA:0009006" ; oboInOwl:hasExactSynonym "sperm cell", "spermatozoid", "spermatozoon" ; a owl:Class ; rdfs:label "sperm" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000019" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000255, obo:CL_0000408, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000018 ] . obo:CL_0000020 obo:IAO_0000115 "An euploid male germ cell of an early stage of spermatogenesis." ; oboInOwl:hasDbXref "BTO:0000958", "CALOHA:TS-2193", "EMAPA:31482", "FBbt:00004934", "FBbt:00004935", "FMA:72291", "ZFA:0009007" ; oboInOwl:hasExactSynonym "spermatogonial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "spermatogonium" ; rdfs:subClassOf obo:CL_0000015, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001394 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001501 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000015 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001394 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001501 ] ) ] . obo:CL_0000021 obo:IAO_0000115 "Female germ cell is a germ cell that supports female gamete production." ; oboInOwl:hasDbXref "MA:0000388", "VHOG:0001530", "ncithesaurus:Egg" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "female germ cell" ; rdfs:subClassOf obo:CL_0000255, obo:CL_0000586, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048477 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048477 ] ) ] . obo:CL_0000022 obo:IAO_0000115 "A stem cell that is the precursor of female gametes." ; oboInOwl:hasDbXref "FBbt:00004873" ; a owl:Class ; rdfs:label "female germ line stem cell" ; rdfs:subClassOf obo:CL_0000014, obo:CL_0000021 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000021 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0017145 ] ) ] . obo:CL_0000023 obo:IAO_0000115 "A female germ cell that has entered meiosis." ; oboInOwl:hasDbXref "BTO:0000964", "CALOHA:TS-0711", "FBbt:00004886", "FMA:18644", "MESH:D009865", "WBbt:0006797", "ZFA:0001109" ; oboInOwl:hasRelatedSynonym "oogonium" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "oocyte" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000021, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0007143 ] . obo:CL_0000024 obo:IAO_0000115 "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." ; oboInOwl:hasDbXref "FMA:83673", "ZFA:0005878" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "oogonial cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000021, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000670 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0000278 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000021 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0000278 ] ) ] . obo:CL_0000025 obo:IAO_0000115 "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." ; oboInOwl:hasDbXref "BTO:0000369", "BTO:0003801", "CALOHA:TS-2191", "FBbt:00057012", "FMA:67343", "MESH:D010063", "ZFA:0001570" ; oboInOwl:hasExactSynonym "mature oocyte", "ovum" ; a owl:Class ; rdfs:label "egg cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000675, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0007143 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000023 ] ; foaf:depiction "https://www.swissbiopics.org/api/image/Egg_cell.svg"^^xsd:anyURI . obo:CL_0000026 obo:IAO_0000115 "A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte." ; oboInOwl:hasDbXref "BTO:0000953", "FBbt:00004878" ; oboInOwl:hasRelatedSynonym "nurse cell" ; a owl:Class ; rdfs:label "invertebrate nurse cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000255, obo:CL_0000412, obo:CL_4029002, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000722 ] . obo:CL_0000027 obo:IAO_0000115 "A smooth muscle cell derived from the neural crest." ; a owl:Class ; rdfs:label "smooth muscle cell neural crest derived" ; rdfs:subClassOf obo:CL_0000192, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000008 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] ) ] . obo:CL_0000028 a owl:Class ; rdfs:label "CNS neuron (sensu Nematoda and Protostomia)" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000338 ] . obo:CL_0000029 obo:IAO_0000115 "Any neuron that develops from some migratory neural crest cell." ; oboInOwl:hasDbXref "ZFA:0009009" ; oboInOwl:hasExactSynonym "neuron neural crest derived" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "neural crest derived neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000540, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002676 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] ) ] ; skos:prefLabel "neural crest derived neuron" . obo:CL_0000030 obo:IAO_0000115 "A non-terminally differentiated cell that develops form the neuroectoderm. Glioblast has the potential to differentiate into various types of glial cells, including astrocytes and oligodendrocytes." ; oboInOwl:hasDbXref "ZFA:0009010" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "glioblast" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000133 ] . obo:CL_0000031 obo:IAO_0000115 "A cell that will develop into a neuron often after a migration phase." ; oboInOwl:hasDbXref "BTO:0000930", "FMA:70563", "ZFA:0009011" ; oboInOwl:hasExactSynonym "neuroblast" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "neuroblast (sensu Vertebrata)" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_7742 ] ; skos:prefLabel "neuroblast (sensu Vertebrata)" . obo:CL_0000032 obo:IAO_0000115 "A cell of a platelike structure, especially a thickened plate of ectoderm in the early embryo, from which a sense organ develops." ; oboInOwl:hasDbXref "ZFA:0009012" ; oboInOwl:hasExactSynonym "neural placode cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "neuroplacodal cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000255, obo:CL_0002321, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000114 ] . obo:CL_0000033 obo:IAO_0000115 "An exocrine cell characterized by loss of part of the cytoplasm during the process of secretion. The secreted substance is accumulated at the apical end and is either budded off through the plasma membrane producing secreted vesicles or dissolved in the cytoplasm that is lost during secretion." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "apocrine cell" ; rdfs:subClassOf obo:CL_0000152 . obo:CL_0000034 obo:IAO_0000115 "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "CALOHA:TS-2086", "FMA:63368", "ZFA:0005957" ; oboInOwl:hasExactSynonym "animal stem cell" ; oboInOwl:inSubset cl:cellxgene_subset, cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’." ; rdfs:label "stem cell" ; rdfs:subClassOf obo:CL_0000255, obo:CL_0011115, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_33208 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0017145 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0017145 ] ) ] ; skos:prefLabel "stem cell" . obo:CL_0000035 obo:IAO_0000115 "A stem cell that self-renews as well as give rise to a single mature cell type." ; oboInOwl:hasDbXref "FMA:70569", "ZFA:0009013" ; oboInOwl:hasExactSynonym "unipotent stem cell", "unipotential stem cell" ; a owl:Class ; rdfs:label "single fate stem cell" ; rdfs:subClassOf obo:CL_0000723, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001400 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001400 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0017145 ] ) ] . obo:CL_0000036 obo:IAO_0000115 "A somatic stem cell that is committed to an epithelial fate, possessing the capacity for self-renewal and the ability to differentiate into one or more distinct mature cell types of the epithelial lineage. This cell is crucial for the development, homeostasis, repair, and regeneration of epithelial tissues." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "epithelial stem cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "epithelial fate stem cell" ; rdfs:subClassOf obo:CL_0000723, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030855 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000723 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030855 ] ) ] . obo:CL_0000037 obo:IAO_0000115 "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000725", "CALOHA:TS-0448", "FMA:86475", "MESH:D006412", "VHOG:0001485", "ZFA:0009014" ; oboInOwl:hasExactSynonym "blood forming stem cell", "hemopoietic stem cell" ; oboInOwl:hasRelatedSynonym "HSC", "colony forming unit hematopoietic" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative." ; rdfs:label "hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0000723, obo:CL_0008001, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000566 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002244 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000988 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002244 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048103 ] ) ] ; skos:prefLabel "hematopoietic stem cell" . obo:CL_0000038 obo:IAO_0000115 "A progenitor cell committed to the erythroid lineage." ; oboInOwl:hasDbXref "BTO:0004911", "ZFA:0009015" ; oboInOwl:hasRelatedSynonym "BFU-E", "CFU-E", "blast forming unit erythroid", "burst forming unit erythroid", "colony forming unit erythroid", "erythroid stem cell" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset ; a owl:Class ; rdfs:label "erythroid progenitor cell" ; rdfs:subClassOf obo:CL_0000764, obo:CL_0000839, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000050 ] ; skos:prefLabel "erythroid progenitor cell" . obo:CL_0000039 obo:IAO_0000115 "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." ; oboInOwl:hasDbXref "ZFA:0009016" ; oboInOwl:inSubset cl:general_cell_types_upper_slim, ubprop:_upper_level ; a owl:Class ; rdfs:comment "Originally this term had some plant germ line cell children." ; rdfs:label "germ line cell" ; rdfs:subClassOf obo:CL_0000000, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0022414 ] ; skos:prefLabel "germ line cell" . obo:CL_0000040 obo:IAO_0000115 "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." ; oboInOwl:hasDbXref "CALOHA:TS-1195", "FMA:83553", "ZFA:0009017" ; oboInOwl:hasRelatedSynonym "CFU-M", "colony forming unit macrophage", "colony forming unit monocyte", "monocyte stem cell" ; a owl:Class ; rdfs:comment "Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid." ; rdfs:label "monoblast" ; rdfs:subClassOf obo:CL_0000763, obo:CL_0002194, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017503 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000791 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005730 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002009 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002194 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017503 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000791 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005730 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030224 ] ) ] . obo:CL_0000041 obo:IAO_0000115 "A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive." ; obo:IAO_0000116 "The status of eosinophils as true professional antigen presenting cells is unclear, despite their ability to present exogenous peptides and peptides processed from exogenous proteins (in certain studies) via MHC Class II and activate T cells. Per the equivalence axioms, 'eosinophil' is reasoned to be a subclass of 'professional antigen presenting cell', though the role of eosinophils as such in the body may be limited." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "polymorphonuclear leucocyte", "polymorphonuclear leukocyte" ; oboInOwl:hasExactSynonym "mature eosinocyte", "mature eosinophil leucocyte", "mature eosinophil leukocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Eosinophils are CD125-positive (IL-5R), GM-CSFR-positive, IL-3R-positive, VLA4-positive. They can also express MHC Class I & II, CD4, CD9, CD11a, CD11b, CD11c, CD13, CD15, CD16, CD17, CD18, CD24, CD25,CD28, CD29, CD32, CD33, CD35, CD37, CD39, CD43, CD44, CD45, CD45RB, CD45RO, CD46, CD47, CD48, CD49d, CD49f, CD50, CD52, CD53, CD54, CD55, CD58, CD59, CD62L, CD63, CD65, CD66, CD69, CD71, CD76, CD80, CD81, CD82, CD86, CD87, CD88, CD89, CD92, CD95, CD97, CD98, CD99, CD100, CD101, CD116, CD117, CD119, CD120, CD123, CD124, CD125, CD131, CD137, CD139, CD148, CD149, CD151, CD153, CD156, CD162, CD161, CD162, CD165, CD174, CD182, CD183, CD191, CD192, CD193, CD196, CD213, IL9R, ad integrin, beta-7 integrin, FceRI, IL13Ra1, TGFbR, PAFR, LTB4R, C3aR, CystLT1R, CystLT2R, fMLPR, CRTH2 (PGD2 receptor), histamine 4R, IDO, KYN, PAR-2, Siglec-8, Siglec-10, LIR1, LIR2, LIR3, LIR7, TLR7, TLR8, and VLA-4. Eosinophils can also secrete CXCL1, eotaxin-1, GM-CSF, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL-16, IL-18, IFN-gamma, LTC4, MIP-1alpha, NGF, PAF, RANTES, substance P, TGF-alpha, TGF-beta, TNF-alpha, and VIP." ; rdfs:label "mature eosinophil" ; rdfs:subClassOf obo:CL_0000145, obo:CL_0000771, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007152 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007858 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000014046 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000014047 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000022006 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0005634 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001979 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009129 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000774 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002495 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002540 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045730 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000771 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007152 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007858 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000014046 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000014047 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000022006 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0005634 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001979 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009129 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002495 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002540 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045730 ] ) ] . obo:CL_0000042 obo:IAO_0000115 "A myeloblast committed to the neutrophil lineage. This cell type is GATA-1 positive, C/EBPa-positive, AML-1-positive, c-myb-positive and has low expression of PU.1 transcription factor." ; oboInOwl:hasDbXref "ZFA:0009018" ; oboInOwl:hasRelatedSynonym "neutrophilic granuloblast" ; a owl:Class ; rdfs:comment "These cells are CD11b-negative, CD15-negative, CD16-negative, CD35-negative, CD49d-positive, CD68-positive, lactotransferrin-negative, and fMLP receptor-negative. They are found in the Band 3 fraction." ; rdfs:label "neutrophilic myeloblast" ; rdfs:subClassOf obo:CL_0000834, obo:CL_0000835, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000010799 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000014362 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000834 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000835 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000010799 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000014362 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030223 ] ) ] . obo:CL_0000043 obo:IAO_0000115 "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." ; oboInOwl:hasBroadSynonym "polymorphonuclear leucocyte", "polymorphonuclear leukocyte" ; oboInOwl:hasDbXref "BTO:0001026", "CALOHA:TS-0688" ; oboInOwl:hasExactSynonym "mature basophil leucocyte", "mature basophil leukocyte" ; a owl:Class ; rdfs:comment "Mature basophils are also capable of producing IL-3, IL-5, IL-6, IL-8, IL-13, IL-25, CCL22, tslp, vegf, and LTC4." ; rdfs:label "mature basophil" ; rdfs:subClassOf obo:CL_0000767, obo:CL_0002274, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0005634 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001979 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000770 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002349 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002351 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002830 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032616 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032633 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048295 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000767 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0005634 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001979 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002349 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002351 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002830 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0008015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032616 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032633 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048295 ] ) ] . obo:CL_0000044 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000051 ; a owl:Class ; owl:deprecated true . obo:CL_0000045 obo:IAO_0000115 "OBSOLETE (was not defined before being made obsolete)." ; a owl:Class ; rdfs:comment "Consider using term 'pro-T cell ; CL:0000827' or the term 'thymocyte ; CL:0000893' or one of its children instead." ; rdfs:label "obsolete thymus processed stem cell" ; owl:deprecated true . obo:CL_0000046 obo:IAO_0000115 "OBSOLETE (was not defined before being made obsolete)." ; a owl:Class ; rdfs:comment "Consider using term 'pro-B cell ; CL:0000826' or the term 'immature B cell ; CL:0000816 or one of its children instead." ; rdfs:label "obsolete bursa processed stem cell" ; owl:deprecated true . obo:CL_0000047 obo:IAO_0000115 "An undifferentiated neural cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple central nervous system neuronal and glial cell types." ; oboInOwl:hasDbXref "BTO:0002881", "CALOHA:TS-2360", "FMA:86684", "ZFA:0009019" ; oboInOwl:hasExactSynonym "NSC", "neuronal stem cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "neural stem cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000133 ] . obo:CL_0000048 obo:IAO_0000115 "A stem cell that can give rise to multiple lineages of cells." ; oboInOwl:hasDbXref "FMA:84789", "ZFA:0009020" ; oboInOwl:hasExactSynonym "multi-fate stem cell", "multifate stem cell", "multipotent cell", "multipotent stem cell" ; a owl:Class ; rdfs:label "multi fate stem cell" ; rdfs:subClassOf obo:CL_0000034, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001402 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0017145 ] ) ] ; skos:prefLabel "multi fate stem cell" . obo:CL_0000049 obo:IAO_0000115 "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0004730", "ZFA:0009021" ; oboInOwl:hasExactSynonym "common myeloid precursor" ; oboInOwl:hasRelatedSynonym "CFU-GEMM", "CFU-S", "CMP", "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte", "multipotential myeloid stem cell", "myeloid stem cell", "pluripotent stem cell (bone marrow)" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059)." ; rdfs:label "common myeloid progenitor" ; rdfs:subClassOf obo:CL_0002032 ; owl:disjointWith obo:CL_0000050, obo:CL_0000051, obo:CL_0000557 ; skos:prefLabel "common myeloid progenitor" . obo:CL_0000050 obo:IAO_0000115 "A progenitor cell committed to the megakaryocyte and erythroid lineages." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0009022" ; oboInOwl:hasExactSynonym "CFU-EM", "CFU-MegE", "MEP", "Meg/E progenitor", "colony forming unit erythroid megakaryocyte", "megakaryocyte/erythrocyte progenitor", "megakaryocyte/erythroid progenitor cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2." ; rdfs:label "megakaryocyte-erythroid progenitor cell" ; rdfs:subClassOf obo:CL_0000763, obo:CL_0002032, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030218 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030219 ] ; owl:disjointWith obo:CL_0000557, obo:CL_0002009 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002032 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030218 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030219 ] ) ] ; skos:prefLabel "megakaryocyte-erythroid progenitor cell" . obo:CL_0000051 obo:IAO_0000115 "A oligopotent progenitor cell committed to the lymphoid lineage." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0009023" ; oboInOwl:hasExactSynonym "common lymphocyte precursor", "common lymphocyte progenitor", "common lymphoid precursor" ; oboInOwl:hasRelatedSynonym "CLP", "ELP", "committed lymphopoietic stem cell", "early lymphocyte progenitor", "lymphoid stem cell", "lymphopoietic stem cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative." ; rdfs:label "common lymphoid progenitor" ; rdfs:subClassOf obo:CL_0002032, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030098 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002032 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030098 ] ) ] . obo:CL_0000052 obo:IAO_0000115 "A stem cell from which all cells of the body can form." ; oboInOwl:hasDbXref "FMA:84790", "MESH:D039901", "ZFA:0009024" ; oboInOwl:hasExactSynonym "totipotential stem cell" ; a owl:Class ; rdfs:label "totipotent stem cell" ; rdfs:subClassOf obo:CL_0000723 ; skos:prefLabel "totipotent stem cell" . obo:CL_0000053 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000059 ; a owl:Class ; owl:deprecated true . obo:CL_0000054 obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000062 ; a owl:Class ; rdfs:comment "synonymous with 'osteoblast'" ; rdfs:label "obsolete bone matrix secreting cell" ; owl:deprecated true . obo:CL_0000055 obo:IAO_0000115 "OBSOLETE. A precursor cell with a limited number of potential fates." ; obo:IAO_0000233 "https://github.com/obophenotype/cell-ontology/issues/2922" ; oboInOwl:consider obo:CL_0011026 ; oboInOwl:hasDbXref "BTO:0000125", "FMA:84782" ; oboInOwl:hasExactSynonym "blast cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Redundant grouping term", "define using PATO mulit-potent or oligopotent?" ; rdfs:label "obsolete non-terminally differentiated cell" ; owl:deprecated true ; skos:prefLabel "non-terminally differentiated cell" . obo:CL_0000056 obo:IAO_0000115 "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." ; oboInOwl:hasDbXref "BTO:0000222", "CALOHA:TS-0650", "FBbt:00005083", "FMA:70335", "VHOG:0001529", "ZFA:0009025" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "myoblast" ; rdfs:subClassOf obo:CL_0000680 ; skos:prefLabel "myoblast" . obo:CL_0000057 obo:IAO_0000115 "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000452", "CALOHA:TS-0362", "FMA:63877", "NCIT:C12482", "VHOG:0001482", "ZFA:0009026" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative." ; rdfs:label "fibroblast" ; rdfs:subClassOf obo:CL_0000499 ; skos:prefLabel "fibroblast" . obo:CL_0000058 obo:IAO_0000115 "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." ; oboInOwl:hasDbXref "BTO:0003607", "FMA:66783", "ZFA:0009027" ; oboInOwl:hasExactSynonym "chrondoplast" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "chondroblast" ; rdfs:subClassOf obo:CL_0002320, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0007009 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0002418 ] ; skos:prefLabel "chondroblast" . obo:CL_0000059 obo:IAO_0000115 "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." ; oboInOwl:hasDbXref "BTO:0001663", "FMA:70576" ; oboInOwl:hasExactSynonym "amelocyte", "enamel secreting cell" ; a owl:Class ; rdfs:comment "non-encoded relationship from VSAO produces VSAO:0000066" ; rdfs:label "ameloblast" ; rdfs:subClassOf obo:CL_0000146, obo:CL_0002077, obo:CL_1100001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005176 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0007000 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0097186 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001763 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0001752 ] . obo:CL_0000060 obo:IAO_0000115 "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell." ; oboInOwl:hasDbXref "BTO:0001769", "CALOHA:TS-0696", "FMA:62999", "MESH:D009804", "ZFA:0009029" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "legacy def: One of the cells forming the outer surface of dental pulp that produces tooth dentin." ; rdfs:label "odontoblast" ; rdfs:subClassOf obo:CL_0000710, obo:CL_0002148, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005176 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0007003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0001751 ] . obo:CL_0000061 obo:IAO_0000115 "Skeletogenic cell that produces cementum (a bony substance that covers the root of a tooth), is part of the odontogenic papilla, and develops from a precementoblast cell." ; oboInOwl:hasDbXref "CALOHA:TS-1164", "FMA:63002", "ZFA:0009030" ; oboInOwl:hasExactSynonym "cementum secreting cell" ; a owl:Class ; rdfs:comment "Legacy def: A cell of ectomesenchymal origin that aids in the formation the cementum layer on the roots of teeth." ; rdfs:label "cementoblast" ; rdfs:subClassOf obo:CL_0000062, obo:CL_0000151, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005176 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0007002 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0001753 ] . obo:CL_0000062 obo:IAO_0000115 "Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell." ; oboInOwl:hasDbXref "BTO:0001593", "CALOHA:TS-0720", "FMA:66780", "ZFA:0009031" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "non-encoded relationships from VSAO - capable_of_producing VSAO:0000020" ; rdfs:label "osteoblast" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0007010 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0008883 ] . obo:CL_0000063 obo:IAO_0000115 "OBSOLETE: A classification of cells by their microscopic appearance." ; oboInOwl:consider "CL:0000000", "CL:0000003", "CL:0001034" ; a owl:Class ; rdfs:comment "This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its microscopic appearance. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate." ; rdfs:label "obsolete cell by histology" ; owl:deprecated true . obo:CL_0000064 obo:IAO_0000115 "A cell that has a filiform extrusion of the cell surface." ; oboInOwl:hasDbXref "VHOG:0001532", "XAO:0000031", "ZFA:0009032" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "ciliated cell" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005929 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005929 ] ) ] ; skos:prefLabel "ciliated cell" . obo:CL_0000065 obo:IAO_0000115 "A neuroepithelial glial cell, derived from a radial glial cell originating from the neuroectoderm, lines the ventricles of the brain and the central canal of the spinal cord. This cell is characterized by the presence of cilia on its apical surface, which can be motile or non-motile." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0001724", "FMA:70550", "ZFA:0009033" ; oboInOwl:hasNarrowSynonym "ependymocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "ependymal cell" ; rdfs:subClassOf obo:CL_0000067, obo:CL_0000125, obo:CL_0000710, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004670 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002207 ; owl:someValuesFrom obo:CL_0000681 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004670 ] ) ] ; skos:prefLabel "ependymal cell" . obo:CL_0000066 obo:IAO_0000115 "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000414", "CALOHA:TS-2026", "CARO:0000077", "FBbt:00000124", "FMA:66768", "WBbt:0003672", "ZFA:0009034" ; oboInOwl:hasExactSynonym "epitheliocyte" ; oboInOwl:inSubset cl:cellxgene_subset, cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "epithelial cell" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000483 ] ; owl:disjointWith obo:CL_0000738 ; skos:prefLabel "epithelial cell" ; foaf:depiction "https://www.swissbiopics.org/api/image/Epithelial_cells.svg"^^xsd:anyURI . obo:CL_0000067 obo:IAO_0000115 "An epithelial cell that has a cilia." ; oboInOwl:hasDbXref "FMA:70605", "ZFA:0009035" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "ciliated epithelial cell" ; rdfs:subClassOf obo:CL_0000064, obo:CL_0000066 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005929 ] ) ] ; skos:prefLabel "ciliated epithelial cell" . obo:CL_0000068 obo:IAO_0000115 "An epithelial cell that is part of a duct." ; oboInOwl:hasDbXref "ZFA:0009372" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "duct epithelial cell" ; rdfs:subClassOf obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000058 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000058 ] ) ] . obo:CL_0000069 a owl:Class ; rdfs:label "branched duct epithelial cell" ; rdfs:subClassOf obo:CL_0000068 . obo:CL_0000070 a owl:Class ; rdfs:label "obsolete epithelial cell of gland" ; owl:deprecated true . obo:CL_0000071 obo:IAO_0000115 "An endothelial cell that lines the vasculature." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0009036" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "blood vessel endothelial cell" ; rdfs:subClassOf obo:CL_0002139, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004638 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ] ) ] ; skos:prefLabel "blood vessel endothelial cell" . obo:CL_0000072 a owl:Class ; rdfs:label "non-branched duct epithelial cell" ; rdfs:subClassOf obo:CL_0000068, obo:CL_0002078 . obo:CL_0000073 obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000215 ; a owl:Class ; rdfs:label "obsolete barrier epithelial cell" ; owl:deprecated true . obo:CL_0000074 obo:IAO_0000115 "Obsolete. Use PO:0000066 from Plant Ontology instead. A cell that constitutes the mesophyll of a hydathode and is located between the xylem endings and the epidermis. Proposed to be involved in the retrieval of solutes from the xylem sap." ; obo:IAO_0100001 obo:PO_0000066 ; a owl:Class ; rdfs:label "obsolete epithem cell" ; owl:deprecated true . obo:CL_0000075 obo:IAO_0000115 "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0009038" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "columnar/cuboidal epithelial cell" ; rdfs:subClassOf obo:CL_0000066 ; skos:prefLabel "columnar/cuboidal epithelial cell" . obo:CL_0000076 oboInOwl:hasDbXref "CALOHA:TS-1249", "ZFA:0009039" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "squamous epithelial cell" ; rdfs:subClassOf obo:CL_0000066 ; skos:prefLabel "squamous epithelial cell" . obo:CL_0000077 obo:IAO_0000115 "A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:66773", "ZFA:0009040" ; oboInOwl:hasExactSynonym "mesotheliocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport." ; rdfs:label "mesothelial cell" ; rdfs:subClassOf obo:CL_0000076, obo:CL_0002078, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001136 ] . obo:CL_0000078 obo:IAO_0000115 "Any squamous epithelial cell that is part of some periderm." ; oboInOwl:hasDbXref "ZFA:0009041" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "peridermal cell" ; rdfs:subClassOf obo:CL_0000076, obo:CL_0000362, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003055 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003055 ] ) ] . obo:CL_0000079 obo:IAO_0000115 "An epithelial cell, organized into multiple layers, with only the basal layer being in contact with the basement membrane." ; oboInOwl:hasDbXref "ZFA:0009042" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "stratified epithelial cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000357 ] . obo:CL_0000080 obo:IAO_0000115 "A cell which moves among different tissues of the body, via blood, lymph, or other medium." ; oboInOwl:hasDbXref "ZFA:0009043" ; a owl:Class ; rdfs:label "circulating cell" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000179 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000179 ] ) ] . obo:CL_0000081 obo:IAO_0000115 "A cell found predominately in the blood." ; oboInOwl:hasDbXref "FMA:62844", "MESH:D001773", "ZFA:0009044" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "blood cell" ; rdfs:subClassOf obo:CL_0000988, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0008015 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000988 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0008015 ] ) ] ; skos:prefLabel "blood cell" . obo:CL_0000082 obo:IAO_0000115 "An epithelial cell of the lung." ; oboInOwl:hasDbXref "BTO:0004299" ; oboInOwl:hasExactSynonym "lung epithelial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "epithelial cell of lung" ; rdfs:subClassOf obo:CL_0002632, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000115 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000115 ] ) ] . obo:CL_0000083 obo:IAO_0000115 "An epithelial cell of the pancreas." ; oboInOwl:hasDbXref "BTO:0000028", "ZFA:0009045" ; oboInOwl:hasExactSynonym "pancreas epithelial cell", "pancreatic epithelial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "epithelial cell of pancreas" ; rdfs:subClassOf obo:CL_0002076, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:CL_0000084 obo:IAO_0000115 "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000782", "CALOHA:TS-1001", "FMA:62870", "MESH:D013601", "VHOG:0001479", "ZFA:0009046" ; oboInOwl:hasExactSynonym "T lymphocyte", "T-cell", "T-lymphocyte" ; oboInOwl:hasRelatedSynonym "immature T cell", "mature T cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "T cell" ; rdfs:subClassOf obo:CL_0000542, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000827 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002456 ] ; owl:disjointWith obo:CL_0000945 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000542 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002456 ] ) ] . obo:CL_0000085 obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000014 ; a owl:Class ; rdfs:comment "Obsoleted as there is no need for a term specific for vertebrates." ; rdfs:label "obsolete germ line stem cell (sensu Vertebrata)" ; owl:deprecated true . obo:CL_0000086 obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000014 ; a owl:Class ; rdfs:comment "Obsoleted as there is no need for a term specific for nematods and protostomes." ; rdfs:label "obsolete germ line stem cell (sensu Nematoda and Protostomia)" ; owl:deprecated true . obo:CL_0000087 obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000016 ; a owl:Class ; rdfs:comment "Obsoleted as there is no need for a term specific for nematods and protostomes." ; rdfs:label "obsolete male germ line stem cell (sensu Nematoda and Protostomia)" ; owl:deprecated true . obo:CL_0000088 obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000022 ; a owl:Class ; rdfs:comment "Obsoleted as there is no need for a term specific for nematods and protostomes." ; rdfs:label "obsolete female germ line stem cell (sensu Nematoda and Protostomia)" ; owl:deprecated true . obo:CL_0000089 obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000016 ; a owl:Class ; rdfs:comment "Obsoleted as there is no need for a term specific for vertebrates." ; rdfs:label "obsolete male germ line stem cell (sensu Vertebrata)" ; owl:deprecated true . obo:CL_0000090 obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000022 ; a owl:Class ; rdfs:comment "Obsoleted as there is no need for a term specific for vertebrates." ; rdfs:label "obsolete female germ line stem cell (sensu Vertebrata)" ; owl:deprecated true . obo:CL_0000091 obo:IAO_0000115 "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Kupffer cells are tissue-resident macrophages located in the liver. They are an integral part of the mononuclear phagocyte system and are responsible for the phagocytosis of dead or dying cells, microbes, and other foreign substances. Kupffer cells account for approximately 80-90% of tissue-resident macrophages in the body. They are found within the lumen of liver sinusoids and interface with microbial populations and products. The primary role of Kupffer cells is to maintain homeostasis in the liver. They continuously filter and cleanse the blood that flows through the liver, removing pathogens, endotoxins, particulate matter, aged and dysfunctional red blood cells, and miscellaneous waste products. These cells also play an important role in maintaining iron homeostasis. During the process of phagocytosis, Kupffer cells recycle iron from degraded red blood cells, which is then utilized in the formation of new erythrocytes. Kupffer cells also play key roles in various immune responses and inflammatory processes. They secrete various types of cytokines and chemokines, which contribute to the activation and mobilization of other immune cells. They can also produce reactive oxygen species and nitric oxide, which have microbicidal actions. Although their activity is essential for host defense, excessive or prolonged activation of Kupffer cells may contribute to hepatic injury, inflammation, and fibrosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:0000685", "FMA:14656" ; oboInOwl:hasExactSynonym "hepatic macrophage", "littoral cell of hepatic sinusoid", "liver macrophage", "macrophagocytus stellatus", "stellate cell of von Kupffer", "von Kupffer cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2." ; rdfs:label "Kupffer cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000091" ; rdfs:subClassOf obo:CL_0000864, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001281 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001925 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002064 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0034102 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000864 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001281 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001925 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002064 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0034102 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" . obo:CL_0000092 obo:IAO_0000115 "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." ; terms:description """Osteoclasts, derived from the monocyte/macrophage lineage, play a crucial role in bone remodeling through bone resorption. They are distinguished from other cells by their large size and their unique ability to secrete enzymes and acids that dissolve the calcium phosphate in bone. The formation of osteoclasts is influenced by two primary factors: macrophage colony-stimulating factor (M-CSF) and the ligand-activated receptor (RANKL) of nuclear factor kappa B (NF-κB). Osteoclasts also collaborate with osteoblasts, responsible for new bone formation, to maintain bone health and adapt bone structure. Their coordinated actions allow continuous remodeling while preserving overall bone strength and integrity. Imbalances in osteoclast activity can lead to pathological conditions. For example, excessive activity may contribute to diseases like osteoporosis, periprosthetic osteolysis, bone tumors, and Paget's disease. Other the other hand, osteoclast deficiency ca result in conditions like osteopetrosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:0000968", "CALOHA:TS-0721", "FMA:66781", "MESH:D010010", "ZFA:0009047" ; oboInOwl:hasRelatedSynonym "chondroclast" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid." ; rdfs:label "osteoclast" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000092" ; rdfs:subClassOf obo:CL_0000518, obo:CL_0000766, obo:CL_0001035, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001850 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001937 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007597 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000011178 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001954 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000576 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045453 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000766 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001474 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001850 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001937 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007597 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000011178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001954 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045453 ] ) ] . obo:CL_0000093 obo:IAO_0000115 "OBSOLETE (was not defined before being made obsolete)." ; a owl:Class ; rdfs:comment "Consider using 'osteoclast ; CL:0000092' instead." ; rdfs:label "obsolete osteochondroclast" ; owl:deprecated true . obo:CL_0000094 obo:IAO_0000115 "A leukocyte with abundant granules in the cytoplasm." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000539", "BTO:0001026", "CALOHA:TS-0422", "FMA:62854", "ZFA:0009048" ; oboInOwl:hasExactSynonym "granular leucocyte", "granular leukocyte", "polymorphonuclear leukocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "granulocyte" ; rdfs:subClassOf obo:CL_0000081, obo:CL_0000766, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030141 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001332 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001969 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000766 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030141 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001969 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0008015 ] ) ] . obo:CL_0000095 oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "neuron associated cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000133 ] ; skos:prefLabel "neuron associated cell" . obo:CL_0000096 obo:IAO_0000115 "A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "poly", "polymorphonuclear leucocyte", "polymorphonuclear leukocyte" ; oboInOwl:hasDbXref "BTO:0003473", "ZFA:0009049" ; oboInOwl:hasExactSynonym "PMN", "mature neutrocyte", "mature neutrophil leucocyte", "mature neutrophil leukocyte", "mature neutrophilic leucocyte", "mature neutrophilic leukocyte", "polymorphonuclear neutrophil", "polynuclear neutrophilic leucocyte", "polynuclear neutrophilic leukocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Neutrophils are also capable of secreting GRO-alpha, IL-1beta, IL-1ra, IL-3, IL-12, IP-10, MIG, MIP-1alpha, MIP-1beta, TGF-beta, TNF-alpha, VEGF, and anti-microbial peptides. They can positively influence the chemotaxis of basophils, T-cells, monocytes, macrophages, dendritic cells, and other neutrophils. Neutrophils are also CD35-positive, CD64-positive, CD89-positive, CD184-positive, and fMLP receptor-positive Ly-6G-positive (mouse), TLR2-low, TLR4-low, and lineage-negative (CD2, CD3, CD5, CD9, CD19, CD36, CD49d, CD56, CD61, CD235a (glycophorin-A))." ; rdfs:label "mature neutrophil" ; rdfs:subClassOf obo:CL_0000234, obo:CL_0000775, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017500 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0070820 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0005634 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001979 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000009978 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000010543 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000010799 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001256 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001257 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001456 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001944 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000007597 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002536 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002690 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032637 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000775 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017500 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0070820 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0005634 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001979 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000009978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000010543 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000010799 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001256 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001257 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001944 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000007597 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002536 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006909 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032637 ] ) ] . obo:CL_0000097 obo:IAO_0000115 "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000830", "CALOHA:TS-0603", "FMA:66784" ; oboInOwl:hasExactSynonym "histaminocyte", "labrocyte", "mastocyte" ; oboInOwl:hasRelatedSynonym "tissue basophil" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5." ; rdfs:label "mast cell" ; rdfs:subClassOf obo:CL_0000766, obo:CL_0002274, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030141 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001865 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001255 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000006169 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000831 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002349 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002539 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002660 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002690 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002830 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030210 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000007431 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000766 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030141 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000006169 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002349 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002539 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002660 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002830 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030210 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000007431 ] ) ] . obo:CL_0000098 obo:IAO_0000115 "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." ; oboInOwl:hasBroadSynonym "neuroepithelial cell" ; oboInOwl:hasDbXref "BTO:0004301", "ZFA:0009050" ; a owl:Class ; rdfs:comment "The term \"neuroepithelial cell\" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710)." ; rdfs:label "sensory epithelial cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0000197 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050906 ] ) ] ; skos:prefLabel "sensory epithelial cell" . obo:CL_0000099 obo:IAO_0000115 "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0003811", "FBbt:00005125", "FMA:67313", "WBbt:0005113", "ZFA:0009051" ; oboInOwl:hasRelatedSynonym "CNS interneuron" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "interneuron" ; rdfs:subClassOf obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0014051 ] ; skos:prefLabel "interneuron" . obo:CL_0000100 obo:IAO_0000115 "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000312", "FBbt:00005123", "FMA:83617", "WBbt:0005409", "ZFA:0009052" ; oboInOwl:hasExactSynonym "motoneuron" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "motor neuron" ; rdfs:subClassOf obo:CL_0000527 ; skos:prefLabel "motor neuron" . obo:CL_0000101 obo:IAO_0000115 "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0001037", "FBbt:00005124", "FMA:84649", "MESH:D011984", "WBbt:0005759", "ZFA:0009053" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "sensory neuron" ; rdfs:subClassOf obo:CL_0000526, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050906 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050906 ] ) ] ; skos:prefLabel "sensory neuron" . obo:CL_0000102 obo:IAO_0000115 "A neuron type that respond to multiple stimuli such as mechanical, thermal and chemical. This neuron type is responsible for integrating different types of sensory inputs, allowing organisms to respond appropriately to diverse environmental challenges." ; oboInOwl:hasDbXref "ZFA:0009054" ; oboInOwl:hasRelatedSynonym "polymodal sensory neuron" ; a owl:Class ; rdfs:label "polymodal neuron" ; rdfs:subClassOf obo:CL_2000032 . obo:CL_0000103 obo:IAO_0000115 "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body." ; oboInOwl:hasDbXref "FMA:67282", "ZFA:0009055" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:label "bipolar neuron" ; rdfs:subClassOf obo:CL_0000099, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070006 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070006 ] ) ] . obo:CL_0000104 obo:IAO_0000115 "A neuron with three or more neurites, usually an axon and multiple dendrites." ; oboInOwl:hasDbXref "FMA:67287", "ZFA:0009056" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "multipolar neuron" ; rdfs:subClassOf obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070026 ] . obo:CL_0000105 obo:IAO_0000115 "Neuron with two neurites that are fused grossly when they protrude from the soma and bifurcate a short distance from the soma." ; oboInOwl:hasDbXref "FMA:67305", "ZFA:0009057" ; a owl:Class ; rdfs:label "pseudounipolar neuron" ; rdfs:subClassOf obo:CL_2000032 . obo:CL_0000106 obo:IAO_0000115 "Neuron with one neurite that extends from the cell body." ; oboInOwl:hasDbXref "FMA:67278", "ZFA:0009058" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "unipolar neuron" ; rdfs:subClassOf obo:CL_2000032 . obo:CL_0000107 obo:IAO_0000115 "A neuron whose cell body is within an autonomic ganglion." ; oboInOwl:hasDbXref "FMA:80121", "ZFA:0009059" ; a owl:Class ; rdfs:label "autonomic neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000032, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002410 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002410 ] ) ] . obo:CL_0000108 obo:IAO_0000115 "A neuron that uses acetylcholine as a vesicular neurotransmitter." ; oboInOwl:hasDbXref "BTO:0004902", "FBbt:00007173", "FMA:84796", "MESH:D059329", "WBbt:0006840", "ZFA:0009060" ; a owl:Class ; rdfs:label "cholinergic neuron" ; rdfs:subClassOf obo:CL_0000151, obo:CL_0000540, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0014055 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0014055 ] ) ] ; skos:prefLabel "cholinergic neuron" . obo:CL_0000109 oboInOwl:hasDbXref "MESH:D059331", "ZFA:0009061" ; a owl:Class ; rdfs:label "adrenergic neuron" ; rdfs:subClassOf obo:CL_4033050 . obo:CL_0000110 obo:IAO_0000115 "A neuron that uses neuropeptides as transmitters." ; oboInOwl:hasDbXref "FBbt:00004101", "ZFA:0009062" ; a owl:Class ; rdfs:label "peptidergic neuron" ; rdfs:subClassOf obo:CL_0000540, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002790 ] . obo:CL_0000111 obo:IAO_0000115 "OBSOLETE A neuron that is part of nerve found outside the central nervous system." ; obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_2000032 ; oboInOwl:hasDbXref "FMA:84664" ; a owl:Class ; rdfs:comment "Merging into CL:2000032." ; rdfs:label "obsolete peripheral neuron" ; owl:deprecated true . obo:CL_0000112 obo:IAO_0000115 "A neuron of the invertebrate central nervous system. This neuron innervates the central complex (CX) of an invertebrate brain and it forms columnar patterns with its dendrites. It is involved in navigation and spatial processing." ; a owl:Class ; rdfs:comment "Columnar neurons have been widely studied in Diptera, locusts, honey bees and other insects. In the mammalian brain, a \"columnar organisation\" is referred to neurons of the neocortex, however these differ from columnar neurons which are found in the insects central nervous system." ; rdfs:label "columnar neuron" ; rdfs:subClassOf obo:CL_0000028, obo:CL_0008028, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007601 ] . obo:CL_0000113 obo:IAO_0000115 "A vertebrate phagocyte with a single nucleus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Mononuclear phagocytes are immune cells that form a critical part of the body's innate immune system, the body's first line of defense against infections. Mononuclear phagocytes are characterized by the presence of a single, large nucleus. The ‘Mononuclear Phagocyte System’ nomenclature was introduced to distinguish mononuclear monocytes and macrophages from other cells with multiple nuclei. However, the cells within the mononuclear phagocyte system represent a highly heterogeneous group, all of which are able to perform highly efficient phagocytosis - engulfing and digesting microbes and cellular debris to fight infections and to maintain normal tissue homeostasis. In addition to phagocytosis, mononuclear phagocytes also secrete chemical compounds to recruit other immune cells to a site of infection. These cells produce different types of signaling molecules, including cytokines, chemokines, and reactive oxygen species, triggering a cascade of responses to ensure rapid and efficient containment and neutralization of invading pathogens. These cells are also involved in antigen presentation, a process essential for stimulating an adaptive immune response. They can process and present antigens to T cells, thereby linking the innate and adaptive immune responses. Mononuclear phagocytes play key roles in tissue repair and remodeling. After infection or injury, these cells help in the clearance of dead cells and debris, a crucial step in the initiation of tissue remodeling and the resolution of inflammation. Overall, mononuclear phagocytes are versatile cells that have tailored their functions to meet the unique challenges of different tissues within the body. They are pivotal in homeostasis, immunity, and inflammation, making them important aspects in a range of human diseases including infection, autoimmunity, and cancer. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:0001433", "ZFA:0009064" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "mononuclear phagocyte" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000113" ; rdfs:subClassOf obo:CL_0000518, obo:CL_0000842 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000518 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] ) ] . obo:CL_0000114 obo:IAO_0000115 "An ectodermal cell that is part of the external ectoderm, forming the outermost layer of the developing embryo. It is characterized by its polarized nature, with distinct apical and basal surfaces (Ferrante Jr., Reinke, & Stanley, 1995). Surface ectodermal cell gives rise to the epidermis, hair follicles, nails, sensory organs, and specialized structures like the apical ectodermal ridge crucial for limb development (Skoufa et al., 2024)." ; terms:description """Surface ectoderm cells give rise to external structures such as the epidermis, hair, nails, and sweat glands. They are critical during the early stages of embryonic development, where they delineate and create the organism's exterior body plan. Beyond forming the organism's physical exterior, surface ectodermal cells have other significant roles. For instance, these cells lead to the development of the anterior pituitary gland and the enamel of the teeth. They are also integral to the formation of the sensory organs, including the eyes and the ears. In the eyes, they form the cornea and lens epithelium. In the ears, they form the external ear canal and certain parts of the inner ear. Therefore, these cells are instrumental in the development of various sensory systems in an organism. Certain abnormalities or mutations in surface ectodermal cells could lead to medical conditions known as ectodermal dysplasias. These are a group of inherited disorders affecting the development or function of teeth, hair, nails, and sweat glands. Therefore, understanding the formation and function of surface ectodermal cells is also important in identifying and addressing certain genetic disorders and conditions. In summary, surface ectodermal cells are essential in embryonic development, contributing to the creation of the external physical appearance and the sensory organs of an organism. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:72552" ; oboInOwl:hasExactSynonym "cell of surface ectoderm", "surface ectoderm cell" ; a owl:Class ; rdfs:label "surface ectodermal cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000114" ; rdfs:subClassOf obo:CL_0000221, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000076 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000221 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000076 ] ) ] . obo:CL_0000115 obo:IAO_0000115 "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0001176", "CALOHA:TS-0278", "FMA:66772", "ZFA:0009065" ; oboInOwl:hasExactSynonym "endotheliocyte" ; oboInOwl:inSubset cl:cellxgene_subset, cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]." ; rdfs:label "endothelial cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000222 ] ; skos:prefLabel "endothelial cell" . obo:CL_0000116 obo:IAO_0000115 "Pioneer neurons establish a pathway in the developing central nervous system and then undergo programmed cell death once the adult axons, which follow them, have made connections with the target site. Thus, they are a transient cell type involved in axon guidance." ; oboInOwl:hasDbXref "FBbt:00005128", "ZFA:0009066" ; a owl:Class ; rdfs:label "pioneer neuron" ; rdfs:subClassOf obo:CL_0000540 . obo:CL_0000117 oboInOwl:hasDbXref "ZFA:0009067" ; a owl:Class ; rdfs:label "CNS neuron (sensu Vertebrata)" ; rdfs:subClassOf obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] . obo:CL_0000118 obo:IAO_0000115 "Basket cells are inhibitory GABAergic interneurons of the brain. In general, dendrites of basket cells are free branching and contain smooth spines. Axons are highly branched. The branched axonal arborizations give rise to basket-like structures that surround the soma of the target cell. Basket cells form axo-somatic synapses, meaning their synapses target somas of other cells." ; terms:contributor ; oboInOwl:hasDbXref "ZFA:0009068" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "basket cell" ; rdfs:subClassOf obo:CL_0011005, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070002 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070002 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ) ] ; skos:prefLabel "basket cell" . obo:CL_0000119 obo:IAO_0000115 "Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004." ; oboInOwl:hasDbXref "MESH:D000080906", "ZFA:0009069" ; oboInOwl:hasExactSynonym "Golgi cell", "Golgi neuron", "cerebellar Golgi neuron", "cerebellum Golgi cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cerebellar Golgi cell" ; rdfs:subClassOf obo:CL_4023057, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002956 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002113 ; owl:someValuesFrom obo:UBERON_0002956 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002360 ; owl:someValuesFrom obo:UBERON_0002974 ] ; skos:prefLabel "cerebellar Golgi cell" ; foaf:depiction , . obo:CL_0000120 obo:IAO_0000115 "A neuron of the vertebrate central nervous system that is small in size. This general class includes small neurons in the granular layer of the cerebellar cortex, cerebral cortex neurons that are not pyramidal cells and small neurons without axons found in the olfactory bulb." ; oboInOwl:hasDbXref "BTO:0003393", "ZFA:0009070" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "granule cell" ; rdfs:subClassOf obo:CL_2000029 ; skos:prefLabel "granule cell" . obo:CL_0000121 obo:IAO_0000115 "An inhibitory neuron and the sole output neuron of the cerebellar cortex, the Purkinje cell's soma is located between the granular and molecular layers of the cerebellum. It is one of the largest neural cells in the mammalian brain, ranging from 50 to 80 micrometres in diameter. Purkinje cells have planar, fan-shaped dendrites that branch extensively with little overlap. This cell type receives synaptic input from parallel fibres, which modulate high-frequency spike activity known as \"simple spikes,\" and climbing fibres, which modulate infrequent calcium spike activity known as \"complex spikes\". Purkinje cells are involved in motor coordination, particularly in correcting movements in progress." ; terms:description """Purkinje cells, named after the Czech anatomist Jan Evangelista Purkyně who discovered them, are unique inhibitory neurons in the cerebellar cortex. They are a critical part of the vertebrate nervous system as they provide the only signal output from the cortex to the cerebellar nuclei. They are one of the few types of neurons that are large enough to be seen with the naked eye. The most distinct hallmark of Purkinje cells is their elaborate dendritic arbor, which forms a broad and intricately branching structure resembling a tree. These numerous branches each receive excitatory synaptic inputs from more than 100,000 parallel fibers; in addition, a single climbing fiber makes hundreds of synapses to the soma and proximal dendrites. A single long axon forms an inhibitory projection to the cerebellar nuclei. Purkinje cells play key roles in the coordination of fine, voluntary motor movements and balance. As the sole output of all motor coordination in the cerebellar cortex, they serve as a central relay in the cerebro-cerebellar loop. Each Purkinje cell receives two types of synaptic input: one from parallel fibers (which are axons of granule cells), and the other from climbing fibers (originating from the inferior olivary nucleus). The Purkinje cells process and integrate these diverse kinds of input signals to generate output that controls timing and coordination of movements. Purkinje neurons show considerable synaptic plasticity. Throughout life, these cells continue to undergo long-term potentiation and depression at parallel fiber synapses, which cause long-lasting increase or decrease, respectively, of synaptic transmission and have been proposed as mechanisms for motor learning. Purkinje cells are also known to be implicated in a variety of diseases. Their progressive loss is a prime feature in certain types of ataxia, a collective term used to describe conditions characterized by loss of muscular control and coordination. Furthermore, a significant reduction in the density of Purkinje cells has been reported in conditions such as autism and Huntington’s disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:0001011", "CALOHA:TS-0845", "FMA:67969", "ZFA:0009071" ; oboInOwl:hasExactSynonym "Purkinje neuron", "cerebellar Purkinje cell" ; oboInOwl:hasRelatedSynonym "PC", "PN" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Neurodegenerative disorders affecting Purkinje cells disrupt motor functions. Some of the neurodegenerative disorders that causes loss and degeration of Purkinje cells are Spinocerebellar ataxias (SCAs) (Josef P Kapfhammer and Etsuko Shimobayashi 2023), Friedreich's ataxia (FRDA) (Kevin C Kemp et al., 2016), Fetal alcohol syndrome (Laurent Servais et al., 2016), Dandy-Walker malformation (Alexander Atamian et al., 2024)." ; rdfs:label "Purkinje cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000121" ; rdfs:subClassOf obo:CL_0000617, obo:CL_1001611, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002979 ] ; skos:prefLabel "Purkinje cell" ; foaf:depiction , . obo:CL_0000122 obo:IAO_0000115 "A neuron that has dendritic processes radiating from the cell body forming a star-like shape." ; oboInOwl:hasDbXref "BTO:0002316", "ZFA:0009072" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:label "stellate neuron" ; rdfs:subClassOf obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070010 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070010 ] ) ] ; skos:prefLabel "stellate neuron" . obo:CL_0000123 oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "neuron associated cell (sensu Vertebrata)" ; rdfs:subClassOf obo:CL_0000095, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_7742 ] . obo:CL_0000124 obo:IAO_0000233 ; a owl:Class ; rdfs:comment "This is a grouping class that is no longer needed or wanted." ; rdfs:label "obsolete glial cell (sensu Nematoda and Protostomia)" ; owl:deprecated true . obo:CL_0000125 obo:IAO_0000115 "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Glial cells, also known as neuroglia or simply glia, are non-neuronal cells in the central and peripheral nervous systems that provide support and protection for neurons. They constitute approximately half of the total cells in the human brain and more than half in other parts of the nervous system. Glial cells perform several key functions including, but not limited to, maintaining homeostasis, forming the myelin sheath around the neuron axons, and providing support and nutrition to neurons. These different functions are performed by various glial cell types, including astrocytes, oligodendrocytes, microglia and other specialized types. Astrocytes, for example, are the most abundant glial cells and provide metabolic and nutrient support to neurons, help regulate the extracellular ion and neurotransmitter levels, and play a role in the formation and maintenance of the blood-brain barrier, contributing to the overall homeostasis and functioning of the nervous system. Additionally, astrocytes are involved in synaptic communication and participate in processes such as synaptogenesis and synaptic pruning. Oligodendrocytes in the central nervous system function to insulate neurons by producing a fatty substance known as myelin. The myelin sheath enhances the speed and efficiency of nerve impulse conduction along the axons. Microglia, the immune cells of the central nervous system, protect neurons from pathogens and clear away dead neurons through phagocytosis, a process also known as cellular eating. They also contribute to the regulation of inflammation in response to signals of tissue damage or infection in the central nervous system by releasing cytokines and other signaling molecules that modulate the immune response. Despite their overarching function in the support and protection of neurons, glial cells have also been shown to play significant roles in the pathophysiology of many psychiatric and neurodegenerative diseases, such as Alzheimer’s, Parkinson’s Disease and multiple sclerosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:0002606", "CALOHA:TS-0415", "FBbt:00005144", "FMA:54536", "ZFA:0009073" ; oboInOwl:hasExactSynonym "neuroglial cell" ; oboInOwl:hasRelatedSynonym "neuroglia" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571" ; rdfs:label "glial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000125" ; rdfs:subClassOf obo:CL_0000095 ; skos:prefLabel "glial cell" . obo:CL_0000126 obo:IAO_0000115 "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." ; oboInOwl:hasDbXref "BTO:0000771", "CALOHA:TS-2027", "FMA:54538", "ZFA:0009074" ; oboInOwl:hasExactSynonym "macrogliocyte" ; oboInOwl:hasRelatedSynonym "macroglia" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "macroglial cell" ; rdfs:subClassOf obo:CL_0000125, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000339 ] . obo:CL_0000127 obo:IAO_0000115 "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000099", "CALOHA:TS-0060", "FMA:54537", "ZFA:0009075" ; oboInOwl:hasExactSynonym "astrocytic glia" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive." ; rdfs:label "astrocyte" ; rdfs:subClassOf obo:CL_0000126 . obo:CL_0000128 obo:IAO_0000115 "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000962", "CALOHA:TS-0709", "FMA:54540", "ZFA:0009076" ; oboInOwl:hasExactSynonym "OLs" ; oboInOwl:hasRelatedSynonym "oligodendroglia" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Oligodendrocytes are reportedly MDP-positive and CD4-negative." ; rdfs:label "oligodendrocyte" ; rdfs:subClassOf obo:CL_0000126, obo:CL_4023154, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002453 ] . obo:CL_0000129 obo:IAO_0000115 "A transcriptomically distinct central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Microglial cells, sometimes referred to as microglia, are a type of glial cell that primarily exist within the central nervous system (CNS), notably in the brain and the spinal cord. Classified among the resident immune cells, microglial cells represent about 10% of all cells found within the CNS. These cells are derived from progenitor cells in the yolk sac, which differentiates them from other types of glial cells (such as astrocytes and oligodendrocytes) that are derived from neuroectodermal cell lineages. The primary role of microglial cells is to act as the first and main active form of immune defense in the CNS. They express a vast repertoire of pattern recognition receptors, which allow them to sense and eliminate microbes invading the CNS parenchyma. They represent one of the macrophage populations of the CNS and are responsible for phagocytosis (engulfing and destroying cellular waste or pathogens) in the neural environment. Microglial cells are particularly responsive to pathogens and injuries and change their morphology in reaction to inflammation or insult: In the normal state they are characterized by a ramified shape with small processes; in response to stimuli, some microglia mature and change to an amoeboid shape. Beyond their macrophagic activity, they also perform synaptic pruning during brain development, eliminate unnecessarily produced neurons, and facilitate tissue regeneration and repair. they play integral roles in regulating neural development and supporting cell survival and are important for maintaining tissue homeostasis. While their protective role generally benefits the brain, their over-activation can occasionally lead to neuro-inflammatory diseases, underlining the importance of balanced microglial cell functions. They have been extensively studied for their association with neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasBroadSynonym "brain macrophage" ; oboInOwl:hasDbXref "BTO:0000078", "BTO:0000962", "FMA:54539", "ZFA:0009077" ; oboInOwl:hasExactSynonym "brain-resident macrophage", "hortega cells", "microgliocyte" ; oboInOwl:hasRelatedSynonym "MF.microglia.CNS", "microglia" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive." ; rdfs:label "microglial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000129" ; rdfs:subClassOf obo:CL_0000125, obo:CL_0000878, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002064 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000222 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000034 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001040 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045087 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002064 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045087 ] ) ] . obo:CL_0000130 a owl:Class ; rdfs:label "neuron associated cell (sensu Nematoda and Protostomia)" ; rdfs:subClassOf obo:CL_0000095, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_33317 ] . obo:CL_0000131 obo:IAO_0000115 "An endothelial cell that lines the blood and lymphatic vessels of the digestive tract. This cell forms the gut–vascular barrier (GVB) through tight junctions and crosstalk with pericytes and enteric glial cells, regulating the passage of nutrients and immune cells while restricting microbial translocation into the bloodstream." ; terms:description """Gut endothelial cells are a crucial component of the endothelium, a thin layer of single cells that line the interior surface of blood vessels and lymphatic vessels, including those in the digestive system or \"gut\". These cells plays an integral role in various physiological and metabolic functions, actively participating in nutrient absorption, host defense, and vascular homeostasis in the gut. The primary function of gut endothelial cells lies in their ability to control the passage of materials and the transit of white blood cells into and out of the bloodstream. They achieve this through the formation of a semi-permeable barrier, in which permeability is regulated by tight junctions; complex structures that bring the cells together, sealing the space between them. This ensures a controlled, selective passage of nutrients, ions, and water from the bloodstream into the gut and vice versa, helping maintain homeostasis and overall health. Gut endothelial cells also play a significant role in angiogenesis and serve as a critical regulator of the gut immune responses playing a modulative role in gut immune homeostasis and inflammatory responses. In addition, they generate nitric oxide, a potent vasodilator, which helps in maintaining vascular tonus, preventing platelet and leukocyte adhesion, and decreasing smooth muscle proliferation. These multi-faceted roles make gut endothelial cells indispensable for the normal functioning of the gut and overall health. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "ZFA:0009078" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "gut endothelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000131" ; rdfs:subClassOf obo:CL_0000115, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000223 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ] ) ] . obo:CL_0000132 obo:IAO_0000115 "An hexagonal, flattened, mitochondria-rich endothelial cell that forms a monolayer on the posterior surface of the cornea (the corneal endothelium). Corneal endothelial cells are derived from the neural crest and are responsible for keeping the cornea transparent by maintaining the tissue in a semi-dry state through the action of their ionic pumps and tight junction barrier." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "CALOHA:TS-0172", "FMA:70614", "ZFA:0009079" ; oboInOwl:inSubset cl:cellxgene_subset, cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "corneal endothelial cell" ; rdfs:subClassOf obo:CL_0000115, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001985 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000008 ] . obo:CL_0000133 obo:IAO_0000115 "Ectoderm destined to be nervous tissue." ; oboInOwl:hasDbXref "ZFA:0009080" ; oboInOwl:hasExactSynonym "neurectoderm cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "neurectodermal cell" ; rdfs:subClassOf obo:CL_0000221 ; skos:prefLabel "neurectodermal cell" . obo:CL_0000134 obo:IAO_0000115 "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." ; oboInOwl:hasDbXref "BTO:0002625", "BTO:0003298", "FMA:70546", "ZFA:0009081" ; oboInOwl:hasNarrowSynonym "bone marrow stromal cells", "colony-forming unit-fibroblast", "marrow stromal cells" ; oboInOwl:hasRelatedSynonym "BMSC", "CFU-F", "MSC", "mesenchymal precursor cell", "mesenchymal progenitor cells", "mesenchymal stem cell", "mesenchymal stromal cell", "mesenchymal stromal cells", "stem cells, mesenchymal" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2." ; rdfs:label "mesenchymal stem cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/474" ; rdfs:subClassOf obo:CL_0000048, obo:CL_0002320 ; skos:prefLabel "mesenchymal stem cell" . obo:CL_0000135 obo:IAO_0000115 "An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes." ; oboInOwl:hasDbXref "FMA:63879" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Cultured human fibrocytes are MHCI-positive, MHCII-positive, CD1a-negative, CD3-negative, CD4-negative, CD8-negative, CD10-negative, CD11b-positive, CD13-positive, CD14-negative, CD16-negative, CD18-positive, CD19-negative, CD25-negative, CD29-positive, CD32-positive, CD33-negative, CD34-positive, CD38-negative, CD40-positive, CD44-negative, CD45RO-positive, CD49a-positive, CD49b-positive, CD49c-negative, CD49d-negative, CD49e-positive, CD49f-negative, CD56-negative, CD58-positive, CD61-positive, CD64-positive, CD70-negative, CD71-positive, CD80-positive, CD83-negative, CD86-positive, CD103-negative, CD105-positive, CD181-positive, CD182-negative, CD183-positive, CD184-positive, CD185-negative, CD186-negative, CD191-positive, CD192-negative, CD193-positive, CD194-positive, CD195-positive, CD196-negative, CD197-positive, CD199-positive, desmin-negative, F4/80-positive, Gr1-positive, LSP-1-positive, MHCI-positive, MHCII-positive, alpha-SMA-negative, TCRab-negative, TCRgd-negative, and vimentin-positive. Fibrocytes are also capable of secreting angiogenin, bFGF, CCL2, CCL3, CCL4, CCL8, CXCL1, type I collagen, type III collagen, CTGF, fibronectin, GM-CSF, IL-1a, IL-6, IL-8, IL-10, M-CSF, MMP-9, PDGF-A, TGF-alpha, TGF-beta1, TNF-alpha, and VEGF-A." ; rdfs:label "fibrocyte" ; rdfs:subClassOf obo:CL_0000499, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000057 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002495 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045766 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002495 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045766 ] ) ] . obo:CL_0000136 obo:IAO_0000115 "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000443", "CALOHA:TS-0012", "FMA:63880", "ZFA:0009082" ; oboInOwl:hasExactSynonym "adipose cell", "fat cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "adipocyte" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000325, obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000134 ] ; skos:prefLabel "adipocyte" . obo:CL_0000137 obo:IAO_0000115 "A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi." ; oboInOwl:hasBroadSynonym "bone cell" ; oboInOwl:hasDbXref "BTO:0002038", "CALOHA:TS-1167", "FMA:66779", "VSAO:0000124", "ZFA:0009083" ; a owl:Class ; rdfs:comment "VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118" ; rdfs:label "osteocyte" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0001035, obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002481 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001040 ] . obo:CL_0000138 obo:IAO_0000115 "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." ; oboInOwl:hasDbXref "BTO:0000249", "CALOHA:TS-0138", "FMA:66782", "ZFA:0009084" ; oboInOwl:hasExactSynonym "cartilage cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "chondrocyte" ; rdfs:subClassOf obo:CL_0000153, obo:CL_0000667, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002418 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000058 ] ; skos:prefLabel "chondrocyte" . obo:CL_0000139 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000059 ; a owl:Class ; owl:deprecated true . obo:CL_0000140 obo:IAO_0000115 "Skeletogenic cell that secretes dentine matrix, is derived from odontogenic papilla. Embedded in dentine tissue, and is the transformation of a non-terminally differentiated odontoblast cell." ; oboInOwl:hasDbXref "ZFA:0009086" ; a owl:Class ; rdfs:label "odontocyte" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000060 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000134 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0001751 ] . obo:CL_0000141 obo:IAO_0000115 "An osteocytelike cell with numerous processes, trapped in a lacuna in the cement of the tooth." ; oboInOwl:hasDbXref "FMA:63003", "ZFA:0009087" ; a owl:Class ; rdfs:comment "CHECK: wikipedia says that cementocytes no longer produce cementum, but the phenoscape def is: Skeletogenic cell that produces cementum, is part of the odontogenic papilla, and is a transformation of a cementoblast cell (no change to existing def)." ; rdfs:label "cementocyte" ; rdfs:subClassOf obo:CL_0000137, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005176 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000061 ] . obo:CL_0000142 obo:IAO_0000115 "A cell occurring in the peripheral part of the vitreous body of the eye that may be responsible for production of hyaluronic acid and collagen." ; oboInOwl:hasDbXref "BTO:0004271", "FMA:70620" ; oboInOwl:hasRelatedSynonym "vitreous cell" ; a owl:Class ; rdfs:label "hyalocyte" ; rdfs:subClassOf obo:CL_0000499 . obo:CL_0000143 a owl:Class ; rdfs:label "guidepost cell" ; rdfs:subClassOf obo:CL_0000130 . obo:CL_0000144 obo:IAO_0000115 "OBSOLETE: A classification of cells by their primary end goal or behavior." ; oboInOwl:consider "CL:0000000", "CL:0000003", "CL:0001034" ; a owl:Class ; rdfs:comment "This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its function or behavior. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate." ; rdfs:label "obsolete cell by function" ; owl:deprecated true . obo:CL_0000145 obo:IAO_0000115 "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." ; oboInOwl:hasDbXref "ZFA:0009088" ; oboInOwl:hasRelatedSynonym "APC" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells." ; rdfs:label "professional antigen presenting cell" ; rdfs:subClassOf obo:CL_0000738, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002504 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000738 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002504 ] ) ] . obo:CL_0000146 obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0009089" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "simple columnar epithelial cell" ; rdfs:subClassOf obo:CL_0000075 . obo:CL_0000147 obo:IAO_0000115 "A pigment cell is a cell that contains pigment granules." ; oboInOwl:hasDbXref "VHOG:0001678", "ZFA:0009090" ; oboInOwl:hasExactSynonym "chromatocyte", "chromatophore" ; a owl:Class ; rdfs:label "pigment cell" ; rdfs:subClassOf obo:CL_0000325 ; skos:prefLabel "pigment cell" . obo:CL_0000148 obo:IAO_0000115 "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Melanocytes are specialized cells prevalently found in the skin, but also present in the hair follicles, eyes, inner ear, bones, heart, and brain. Their primary function is the synthesis of melanin, a pigment responsible for coloration of skin, hair, and eyes. The presence and distribution of this pigment play a crucial role in the body's defense mechanism against harmful ultraviolet radiation. In addition to melanin production, melanocytes also engage in a variety of other biological functions. They play a fundamental role in the immune response, owing to their ability to present antigens to T cells. Furthermore, they contribute to the maintenance of the skin's homeostasis by regulating processes such as extracellular matrix remodeling and cytokine production. A balance in melanocyte function is pivotal, as dysfunctions often result in dermatological disorders. For instance, the loss of melanocytes or reduction in their function may lead to hypopigmentation conditions such as vitiligo, whereas an abnormal increase could result in hyperpigmentation disorders or melanoma, a dangerous type of skin cancer. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:0000847", "CALOHA:TS-0613", "FMA:70545", "MESH:D008544", "VHOG:0001679", "ZFA:0009091" ; oboInOwl:hasNarrowSynonym "melanophore" ; oboInOwl:inSubset cl:cellxgene_subset, cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "melanocyte" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000148" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000147, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042470 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000541 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000147 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042470 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000541 ] ) ] . obo:CL_0000149 oboInOwl:hasBroadSynonym "pigment cell" ; a owl:Class ; rdfs:label "visual pigment cell" ; rdfs:subClassOf obo:CL_0000147 ; skos:prefLabel "visual pigment cell" . obo:CL_0000150 obo:IAO_0000115 "An epithelial cell, located in a gland, that is specialised for the synthesis and secretion of specific biomolecules, such as hormones, or mucous." ; oboInOwl:hasDbXref "CALOHA:TS-2085", "FMA:86494" ; oboInOwl:hasExactSynonym "glandular epithelial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "glandular secretory epithelial cell" ; rdfs:subClassOf obo:CL_1100001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002530 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002530 ] ) ] ; skos:prefLabel "glandular secretory epithelial cell" . obo:CL_0000151 obo:IAO_0000115 "A cell that specializes in controlled release of one or more substances." ; oboInOwl:hasDbXref "BTO:0003659", "FMA:86916" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "secretory cell" ; rdfs:subClassOf obo:CL_0000000, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032940 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032940 ] ) ] ; skos:prefLabel "secretory cell" . obo:CL_0000152 obo:IAO_0000115 "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." ; oboInOwl:hasDbXref "FMA:16014", "ZFA:0009092" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "exocrine cell" ; rdfs:subClassOf obo:CL_0000151, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002365 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002365 ] ) ] . obo:CL_0000153 obo:IAO_0000115 "A cell that secretes glycosaminoglycans." ; oboInOwl:hasDbXref "ZFA:0009093" ; oboInOwl:hasExactSynonym "GAG secreting cell" ; oboInOwl:hasNarrowSynonym "hyaluronic acid secreting cell" ; a owl:Class ; rdfs:label "glycosaminoglycan secreting cell" ; rdfs:subClassOf obo:CL_0000327, obo:CL_0000447 ; skos:prefLabel "glycosaminoglycan secreting cell" . obo:CL_0000154 obo:IAO_0000115 "Any secretory cell that is capable of some protein secretion." ; a owl:Class ; rdfs:label "protein secreting cell" ; rdfs:subClassOf obo:CL_0000151, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0009306 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0009306 ] ) ] ; skos:prefLabel "protein secreting cell" . obo:CL_0000155 obo:IAO_0000115 "An epithelial cell of the stomach that is part of the fundic gastric gland. This cell is characterized by a basally located nucleus, abundant rough endoplasmic reticulum, and large apical secretory granules. It produces and secretes pepsinogen, the inactive precursor of the digestive enzyme pepsin." ; oboInOwl:hasDbXref "FMA:62902" ; oboInOwl:hasExactSynonym "chief cell of stomach", "gastric chief cell", "pepsinogen secreting cell", "zymogenic cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "peptic cell" ; rdfs:subClassOf obo:CL_0000152, obo:CL_0000154, obo:CL_0002659, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010038 ] . obo:CL_0000156 obo:IAO_0000115 "OBSOLETE: A cell of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B cells, can be defined, based on the different classes of immunoglobulins that they synthesize." ; a owl:Class ; rdfs:comment "Consider using 'B cell ; CL:0000236' or one of its children instead." ; rdfs:label "obsolete antibody secreting cell" ; owl:deprecated true . obo:CL_0000157 obo:IAO_0000115 "A cell that specializes in secretion of surfactant in the alveoli of the lung." ; a owl:Class ; rdfs:label "surfactant secreting cell" ; rdfs:subClassOf obo:CL_0000151, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043129 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043129 ] ) ] . obo:CL_0000158 obo:IAO_0000115 "A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0004811", "FMA:14119" ; oboInOwl:hasExactSynonym "Clara cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "club cell" ; rdfs:subClassOf obo:CL_0000157, obo:CL_0002202, obo:CL_0008055, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0005902 ] . obo:CL_0000159 oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "seromucus secreting cell" ; rdfs:subClassOf obo:CL_0000151 . obo:CL_0000160 obo:IAO_0000115 "A specialized, columnar, mucus secreting epithelial cell shaped like a flask or goblet. A narrow basal end contains the nucleus while the apical end is swollen by the accumulation of mucus laden secretory granules. Short microvilli project from the apical plasma membrane." ; terms:description """Goblet cells are specialized, simple columnar, secretory epithelial cells that are mostly found in the respiratory and intestinal tracts. The term \"goblet\" refers to their shape, which resembles a flask or goblet, specially at their apical end which is swollen due to the accumulation of secretory granules. The primary function of goblet cells is to to protect and lubricate the underlying tissues by secreting large quantities of mucin, a complex glycoprotein, which forms mucus when hydrated. In the respiratory tract, the mucus secreted by these cells traps dust, bacteria, viruses, and other potentially harmful particles in the inhaled air, preventing them from reaching the delicate tissues of the lungs. In the intestines, the goblet cells secrete mucus that acts as a protective barrier shielding the intestinal epithelium from dietary antigens, pathogens and prevents the intestinal epithelium from being eroded by the actions of the digestive enzymes and the abrasive action of passing food material. Goblet cells are capable of rapidly altering their secretory output in response to stimuli. For example, irritants like smoke or dust can trigger an increased rate of mucus production, as the body attempts to flush out the harmful particles. Conversely, in conditions such as chronic bronchitis and cystic fibrosis, overactive goblet cells can create a thick accumulation of mucus that obstructs the airways and fosters bacterial growth. Lastly, goblet cells are not static, rather, they undergo a dynamic process known as goblet cell metaplasia-differentiation, wherein non-goblet cells in response to chronic injury or inflammation, can differentiate into goblet cells leading to an accumulation of these cells in the tissue, known as goblet cell hyperplasia. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:0001540", "FMA:13148", "ZFA:0009094", "http://en.wikipedia.org/wiki/Goblet_cell" ; oboInOwl:hasExactSynonym "chalice cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "goblet cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000160" ; rdfs:subClassOf obo:CL_0000319, obo:CL_1100001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005902 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0098594 ] ; foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/thumb/c/c4/404_Goblet_Cell_new.jpg/800px-404_Goblet_Cell_new.jpg" . obo:CL_0000161 obo:IAO_0000233 ; oboInOwl:consider obo:CL_0000162 ; a owl:Class ; rdfs:label "obsolete acid secreting cell" ; owl:deprecated true . obo:CL_0000162 obo:IAO_0000115 "An epithelial cell of the stomach that is part of the fundic gastric gland. This cell is characterized by its pyramidal shape, abundant mitochondria, and a complex network of secretory canaliculi lined with microvilli. It secretes hydrochloric acid into the stomach lumen and produces intrinsic factor, essential for vitamin B12 absorption." ; oboInOwl:hasDbXref "BTO:0001780", "FMA:62901" ; oboInOwl:hasExactSynonym "gastric parietal cell", "oxyntic cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Parietal cells have dynamic, actin-supported microvilli that increase in number during active secretion, playing a crucial role in secreting hydrochloric acid and intrinsic factor. The structure and regulation of these microvilli are influenced by proteins such as ASAP3, which modulates Arf6 activity and actin assembly, thereby controlling microvilli formation and parietal cell function." ; rdfs:label "parietal cell" ; rdfs:subClassOf obo:CL_0000152, obo:CL_0002659, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010038 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005902 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001696 ] . obo:CL_0000163 obo:IAO_0000115 "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:83809", "ZFA:0009096" ; oboInOwl:hasExactSynonym "endocrinocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "endocrine cell" ; rdfs:subClassOf obo:CL_0000151, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000949 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0046879 [ a owl:Restriction ; owl:onProperty obo:RO_0002339 ; owl:someValuesFrom obo:UBERON_0001009 ] ) ] ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0046879 [ a owl:Restriction ; owl:onProperty obo:RO_0002339 ; owl:someValuesFrom obo:UBERON_0001009 ] ) ] ] ) ] ; skos:prefLabel "endocrine cell" . obo:CL_0000164 obo:IAO_0000115 "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." ; terms:description """Enteroendocrine cells are a specialized subset of cells located within the epithelial lining of both the small and large intestines, as well as the stomach and pancreas. Constituting less than 1% of the total population of intestinal cells, they are differentiated from a common intestinal cell progenitor, thus sharing lineage with absorptive and goblet cells of the intestines. The distinct characteristic feature of an enteroendocrine cell is its inherent capacity to synthesize and secrete a plethora of gut hormones such as serotonin, somatostatin, neurotensin, cholecystokinin, secretin, gastric inhibitory peptide, motilin, and glucagon-like peptide-1. Integrated within this complex network of signaling agents, these substances control various aspects of the digestive system. Each enteroendocrine cell has its unique combination of hormones to release, determined by its position along the intestinal tract. Intriguingly, these hormones not only modulate local gut function, including motility, absorption and secretion, but also potentiate distant actions on other systems such as endocrine, nervous and immune and play a role in the feeling of satiety. The release of these hormones from enteroendocrine cells is a highly regulated and dynamic process. The cells are equipped with sensory receptors localized on its luminal side that respond to various stimuli, including changes in nutrient composition, chemical or mechanical changes in the gut lumen, or even signals arising from commensal microbiota. This sensory input stimulates a signaling cascade within the cell, culminating in the release of specific hormones into the interstitial fluid. These hormones then make their way into the bloodstream, acting on their respective target receptors to mediate their duties. The multifunctional characteristics of enteroendocrine cells make them crucial for maintaining gut homeostasis and the overall physiological well being of the body. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:0003865", "FMA:62930", "MESH:D019858", "ZFA:0009097" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "enteroendocrine cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000164" ; rdfs:subClassOf obo:CL_0000163, obo:CL_1100001 . obo:CL_0000165 obo:IAO_0000115 "A neuron that is capable of some hormone secretion in response to neuronal signals." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0002691", "FBbt:00005130", "FMA:83810", "ZFA:0009098" ; oboInOwl:hasRelatedSynonym "neurosecretory cell", "neurosecretory neuron" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment """The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. The modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron.""" ; rdfs:label "neuroendocrine cell" ; rdfs:subClassOf obo:CL_0000163, obo:CL_0000527, obo:CL_0000710, obo:CL_1100001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0046879 ] ) ] ; skos:prefLabel "neuroendocrine cell" . obo:CL_0000166 obo:IAO_0000115 "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." ; terms:description """Chromaffin cells, also known as pheochromocytes, are neuroendocrine cells that are typically located in the adrenal medulla, the innermost part of the adrenal gland, which is situated on top of each kidney. Chromaffin cells are also found in small clusters, known as paraganglia, in various locations throughout the body, including the sympathetic nervous system. They derive their name from their ability to stain a brownish-black color upon exposure to chromic salts, a feature made possible due to their high content of granules rich in catecholamines and catecholamine-related neurotransmitters. The primary function of chromaffin cells is the synthesis and release of catecholamines, specifically epinephrine (adrenaline) and norepinephrine (noradrenaline). These neurotransmitters are vital stress hormones that, when released by the adrenal chromaffing cells into the bloodstream, prepare the body for the 'fight or flight' response. This response can enhance the body's performance in a dangerous situation by increasing heart rate, elevating blood sugar, and increasing blood flow to the muscles. The chromaffin cells in paraganglia are responsible for the local release of catecholamines and play a role in regulating blood pressure and other autonomic functions. In addition to their role in stress response, chromaffin cells also contribute to the body's immune response. They secrete several peptides including antimicrobial peptides, and the discovery of LPS and cytokine receptors on chromaffin cells suggests that the adrenal medulla may participate in some aspects of the immune response. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:0000259", "FMA:69263", "ZFA:0009099" ; oboInOwl:hasExactSynonym "phaeochromocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "chromaffin cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000166" ; rdfs:subClassOf obo:CL_0000029, obo:CL_0000568 ; skos:prefLabel "chromaffin cell" . obo:CL_0000167 obo:IAO_0000115 "Any secretory cell that is capable of some peptide hormone secretion." ; oboInOwl:hasDbXref "ZFA:0009100" ; a owl:Class ; rdfs:label "peptide hormone secreting cell" ; rdfs:subClassOf obo:CL_0000151, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030072 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030072 ] ) ] ; skos:prefLabel "peptide hormone secreting cell" . obo:CL_0000168 obo:IAO_0000115 "Any secretory cell that is capable of some insulin secretion." ; oboInOwl:hasDbXref "BTO:0000783", "ZFA:0009101" ; a owl:Class ; rdfs:label "insulin secreting cell" ; rdfs:subClassOf obo:CL_0000154, obo:CL_0000167, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030073 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030073 ] ) ] . obo:CL_0000169 obo:IAO_0000115 "A cell that secretes insulin and is located towards the center of the islets of Langerhans." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "beta cell" ; oboInOwl:hasDbXref "BTO:0000783", "EV:0200009", "FMA:70586", "MA:0002419", "ZFA:0009102", "ncithesaurus:Beta_Cell" ; oboInOwl:hasExactSynonym "B-cell of pancreatic islet", "beta cell of pancreatic islet", "insulin-secreting cell", "pancreatic B cell", "pancreatic B-cell", "pancreatic beta cell", "pancreatic islet core", "type B enteroendocrine cell" ; oboInOwl:hasRelatedSynonym "beta cell islet" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression." ; rdfs:label "type B pancreatic cell" ; rdfs:subClassOf obo:CL_0000168, obo:CL_0008024, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000006 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002351 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000164 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000006 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030073 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-islets-langerhans/v1.2/assets/2d-ftu-pancreas-islets-langerhans.png" . obo:CL_0000170 obo:IAO_0000115 "A cell that secretes glucagon." ; oboInOwl:hasDbXref "FMA:84045", "ZFA:0009103" ; oboInOwl:hasExactSynonym "glucagon-secreting cell" ; a owl:Class ; rdfs:label "glucagon secreting cell" ; rdfs:subClassOf obo:CL_0000167, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070091 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070091 ] ) ] . obo:CL_0000171 obo:IAO_0000115 "A type A enteroendocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000990", "FMA:70585", "MESH:D050416", "ZFA:0009104" ; oboInOwl:hasExactSynonym "alpha cell of islet of Langerhans", "pancreatic alpha cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreatic A cell" ; rdfs:subClassOf obo:CL_0002067, obo:CL_0008024, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000006 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002351 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002067 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000006 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-islets-langerhans/v1.2/assets/2d-ftu-pancreas-islets-langerhans.png" . obo:CL_0000172 obo:IAO_0000115 "Any secretory cell that is capable of some somatostatin secretion." ; oboInOwl:hasDbXref "ZFA:0009105" ; a owl:Class ; rdfs:label "somatostatin secreting cell" ; rdfs:subClassOf obo:CL_0000167, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070253 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070253 ] ) ] . obo:CL_0000173 obo:IAO_0000115 "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000803", "FMA:70587", "ZFA:0005743" ; oboInOwl:hasExactSynonym "D-cell of pancreatic islet", "delta cell of islet", "delta cell of pancreatic islet", "pancreatic D-cell", "pancreatic delta cell", "somatostatin-secreting pancreatic cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreatic D cell" ; rdfs:subClassOf obo:CL_0000502, obo:CL_0008024, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000006 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002351 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000502 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-islets-langerhans/v1.2/assets/2d-ftu-pancreas-islets-langerhans.png" . obo:CL_0000174 obo:IAO_0000115 "Any secretory cell that is capable of some steroid hormone secretion." ; oboInOwl:hasDbXref "ZFA:0009106" ; a owl:Class ; rdfs:label "steroid hormone secreting cell" ; rdfs:subClassOf obo:CL_0000151, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035929 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035929 ] ) ] . obo:CL_0000175 obo:IAO_0000115 "A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0003939", "FMA:18688" ; oboInOwl:hasExactSynonym "corpus luteum cell", "lutein cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "luteal cell" ; rdfs:subClassOf obo:CL_0000179, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002512 ] . obo:CL_0000176 obo:IAO_0000115 "Any secretory cell that is capable of some ecdysteroid secretion." ; a owl:Class ; rdfs:label "ecdysteroid secreting cell" ; rdfs:subClassOf obo:CL_0000174, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045457 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045457 ] ) ] . obo:CL_0000177 obo:IAO_0000115 "Any secretory cell that is capable of some testosterone secretion." ; oboInOwl:hasDbXref "ZFA:0009107" ; a owl:Class ; rdfs:label "testosterone secreting cell" ; rdfs:subClassOf obo:CL_0000151, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035936 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035936 ] ) ] . obo:CL_0000178 obo:IAO_0000115 "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." ; terms:description """Leydig cells are a testosterone-secreting cell in the interstitial area in the testes of males. They are named after Franz Leydig, a German anatomist who discovered these cells in 1850. Uniquely situated within the soft connective tissue surrounding the seminiferous tubules, Leydig cells form an integral part of the male reproductive system. They are usually polygonal cells characterized by well developed smooth endoplasmic reticulum, high lipid content and a large round nucleus. They are found across mammalian species, including humans. The primary function of Leydig cells is the production of androgens, the male sex hormones, the most notable of which is testosterone. Leydig cells synthesize testosterone from cholesterol through a series of enzymatic reactions. The production and release of testosterone are mainly regulated by the luteinizing hormone (LH) released by the anterior pituitary gland. In response to LH, Leydig cells convert cholesterol into testosterone, which then plays a crucial role in the development and maintenance of primary and secondary male sexual characteristics. These include the formation and maturation of male reproductive organs, onset of spermatogenesis, and the presentation of male secondary sexual traits such as the deepening of the voice, growth of facial hair, development of muscles, and a broadening of shoulders. Apart from testosterone production, Leydig cells also secrete insulin-like factor 3 (INSL3) that is essential for testicular descent during embryonic development in males. Dysregulation or loss of Leydig cells can lead to numerous conditions like testosterone deficiency, infertility, and certain forms of testicular cancer. Although not typical, Leydig cells can regenerate if they are damaged, ensuring the continuous production of testosterone and maintaining male reproductive health. They provide an excellent model to study cell differentiation and hormone regulation, thereby enhancing our understanding of reproductive biology and associated disorders. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasBroadSynonym "interstitial cell" ; oboInOwl:hasDbXref "BTO:0000755", "CALOHA:TS-1150", "EMAPA:29655", "FMA:72297", "MESH:D007985", "ZFA:0009108" ; oboInOwl:hasExactSynonym "interstitial cell of Leydig" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Note that the Amphibian Anatomy Ontology (AA) has a class 'leydig cells' but this is unrelated" ; rdfs:label "Leydig cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000178" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000177, obo:CL_4030031, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005212 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0009091 ] . obo:CL_0000179 obo:IAO_0000115 "Any secretory cell that is capable of some progesterone secretion." ; oboInOwl:hasDbXref "ZFA:0009109" ; a owl:Class ; rdfs:label "progesterone secreting cell" ; rdfs:subClassOf obo:CL_0000174, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042701 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042701 ] ) ] . obo:CL_0000180 obo:IAO_0000115 "A steroid hormone secreting cell that secretes estradiol." ; oboInOwl:hasDbXref "ZFA:0009110" ; a owl:Class ; rdfs:label "estradiol secreting cell" ; rdfs:subClassOf obo:CL_0000174, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035938 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035938 ] ) ] . obo:CL_0000181 obo:IAO_0000115 "A cell whose primary function is intermediary metabolism." ; obo:IAO_0000233 ; a owl:Class ; rdfs:comment "Removing this grouping class, because the groupings are incomplete and too hard to maintain." ; rdfs:label "obsolete metabolising cell" ; owl:deprecated true . obo:CL_0000182 obo:IAO_0000115 "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Hepatocytes are the major cell type constituting 70-80% of the liver's cytoplasmic mass, playing crucial roles in maintaining the body's metabolic homeostasis. Dimensions of mature hepatocytes typically range from 20 to 30 μm in humans, but size may vary depending on their location within the liver lobule. Hepatocytes are characterized by high biosynthetic, enzymatic, and endocytic activity. They contain abundant mitochondria, smooth and rough endoplasmic reticulum, peroxisomes, lysosomes, and a large nucleus that is often binucleate. The liver consists of three zones - the periportal Zone 1, midzone 2, and pericentral Zone 3 - which have differential nutrient and oxygen status, and damage susceptibility; hepatocytes in the different zones show signifcant functional heterogeneity ('hepatocyte functional zonation'). Hepatocytes are involved in a multitude of critical functions including the metabolism of lipids, carbohydrates, and proteins, the synthesis of serum proteins (e.g., albumin, transferrin, and lipoproteins), the detoxification and excretion of endogenous and exogenous substances, the storage of vitamins and minerals, and the production and secretion of bile. Heterocytes demonstrate a remarkable regenerative capacity, which enables the liver to recover from injury and loss of tissue mass. Notably, hepatocytes perform biotransformation with both phase I and phase II enzymes, which modify drugs, xenobiotics, and various substances for elimination from the body. Phase I enzymes, such as cytochrome P450, catalyze both oxidative and reductive reactions of many xenobiotics; many of the products of phase I enzymes are substrates for the phase II enzymes, which catalyze conjugation reactions. Alterations in hepatocyte function have significant implications for overall human health and disease. Certain conditions, such as hepatitis, cirrhosis, and liver cancer, can profoundly affect hepatocyte structure and function, thereby disrupting the liver's ability to perform its vital roles within the body. As the primary site for drug metabolism, changes in hepatocyte function can also impact the effectiveness and toxicity of pharmaceuticals. The regenerative ability of hepatocytes makes them valuable cells for liver regenerative medicine and bioartificial liver support systems, and their study has provided significant insights into liver biology and disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:0000575", "CALOHA:TS-0454", "FMA:14515", "ZFA:0009111" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive." ; rdfs:label "hepatocyte" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000182" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000066, obo:CL_0000417, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0005026 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006699 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0098754 ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" . obo:CL_0000183 obo:IAO_0000115 "A cell whose primary function is to shorten." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "contractile cell" ; rdfs:subClassOf obo:CL_0000000 ; skos:prefLabel "contractile cell" . obo:CL_0000184 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000669 ; a owl:Class ; owl:deprecated true . obo:CL_0000185 obo:IAO_0000115 "Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament." ; oboInOwl:hasDbXref "BTO:0002309", "CALOHA:TS-2379", "FMA:67799", "ZFA:0009113" ; oboInOwl:hasExactSynonym "basket epithelial cell", "myoepitheliocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "myoepithelial cell" ; rdfs:subClassOf obo:CL_0000075, obo:CL_0000183 . obo:CL_0000186 obo:IAO_0000115 "An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "MFB" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Myofibroblasts are alpha-SMA-positive, CD34-negative, CD45-negative. They are reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha." ; rdfs:label "myofibroblast cell" ; rdfs:subClassOf obo:CL_0000183, obo:CL_0002320 . obo:CL_0000187 obo:IAO_0000115 "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." ; oboInOwl:hasDbXref "BTO:0000888", "BTO:0000902", "CALOHA:TS-2032", "FBbt:00005074", "FMA:67328", "WBbt:0003675", "ZFA:0009114" ; oboInOwl:hasExactSynonym "muscle fiber", "myocyte" ; oboInOwl:inSubset cl:cellxgene_subset, cl:general_cell_types_upper_slim ; a owl:Class ; rdfs:label "muscle cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000183, obo:CL_0000255, obo:CL_0000393, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000056 ] ; skos:prefLabel "muscle cell" ; foaf:depiction "https://www.swissbiopics.org/api/image/Muscle_cells.svg"^^xsd:anyURI . obo:CL_0000188 obo:IAO_0000115 "A somatic cell located in skeletal muscle." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Skeletal muscle cells, or myocytes, are essential for the musculoskeletal system, featuring a striated appearance from tightly packed sarcomeres. These elongated, multi-nucleated cells convert ATP into mechanical energ and are key for voluntary movement and posture. They also are responsible for maintaining body temperature, storing nutrients, and stabilizing joints. Skeletal muscle cells organize themselves tightly into bundles to form muscle fibers. Embedded within each of these cells are thousands of myofibrils, which are made up of the contractile proteins, actin (the thin filament), and myosin (the thick filament). Contraction of a skeletal muscle cell occurs when these myofibrils shorten, a process driven by the sliding of actin and myosin filaments over each other in a mechanism famously known as the sliding filament theory. Additionally, skeletal muscle cells exhibit a high degree of plasticity, which allows for their adaptation in response to alterations in functional demands or damages. They have an innate regenerative capacity due to the presence of satellite cells—quiescent muscle stem cells that reside within the muscle fibers. Upon muscle injury, these satellite cells become activated, proliferate, and differentiate into new muscle cells, thereby contributing to the repair and growth of injured skeletal muscle. With this, skeletal muscle cells serve not only a pivotal biomechanical function but also possess a great capacity for self-healing and regeneration. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:0004392", "CALOHA:TS-2158", "FMA:9727", "ZFA:0009115" ; oboInOwl:hasExactSynonym "skeletal muscle cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "cell of skeletal muscle" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000188" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001134 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001134 ] ) ] ; skos:prefLabel "cell of skeletal muscle" . obo:CL_0000189 obo:IAO_0000115 "A muscle cell that develops tension more slowly than a fast-twitch fiber." ; terms:description """Slow muscle cells, as the name implies, are a type of muscle cell well known for their slow contractile speed. They are also referred to as type I, slow-twitch, or red muscles because of their high myoglobin content which gives them a dark, reddish appearance. These cells are predominantly found in the postural muscles of the body, such as those in the back and lower limbs. A defining characteristic of slow muscle cells is their significant resistance to fatigue. This is largely due to their efficient oxidative metabolism, which allows them to continuously contract over extended periods without succumbing to fatigue. This extraordinary endurance is facilitated by a high concentration of mitochondria, which enables the efficient use of oxygen for energy production, and capillaries, which supplies the necessary oxygen and nutrients. Additionally, these cells have an abundant supply of myoglobin, a protein that stores and transports oxygen within the muscle cell, further supporting their aerobic metabolism. The primary role of slow muscle cells in the human body is to provide sustained, low-intensity contractions over a prolonged period. They are responsible for maintaining posture and providing stability, rather than delivering short, powerful bursts of activity. They play a pivotal role in supporting various physical activities such as standing, walking, or any form of exercise that requires endurance over speed. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "ZFA:0009116" ; oboInOwl:hasRelatedSynonym "slow muscle fiber" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "slow muscle cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000189" ; rdfs:subClassOf obo:CL_0008046, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000857 ] . obo:CL_0000190 obo:IAO_0000115 "A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron." ; terms:description """Fast muscle cells, also known as type II muscle fibers, are a particular type of muscle cell that specializes in conducting rapid, high-intensity contractions. These cells are primarily found within skeletal muscle groups that are directly involved in gross motor activities, such as running, jumping, or lifting heavy weights. The designation \"fast\" refers to their speed of contraction in response to neural stimuli, which is significantly quicker when compared to other muscle cell types such as slow-twitch or type I muscle fibers. The primary function of fast muscle cells revolves around their role in anaerobic metabolism, which provides the energy needed for short, forceful bursts of power. They contain a high concentration of glycolytic enzymes that facilitate this process, leading to a swift break down of glucose to generate ATP (adenosine triphosphate), the primary energy currency in biological systems. On the downside, the byproduct of this very rapid, anaerobic metabolic process is lactic acid, which can build up and cause muscle fatigue. Fast muscle cells can be further classified into two subtypes based on their metabolic characteristics: type IIa and type IIb/x. Type IIa cells, also known as fast oxidative-glycolytic fibers, possess a good oxygen supply and can function in both anaerobic and aerobic conditions, exhibiting moderate resistance to fatigue. On the other hand, type IIb/x cells, also known as fast glycolytic fibers, primarily rely on anaerobic metabolism and tire out a lot quicker. Both these subtypes can adapt to changing demands due to exercise and conditioning, highlighting the plasticity that is a key characteristic of these versatile muscle cells. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "ZFA:0009117" ; oboInOwl:hasExactSynonym "glycolytic muscle fiber" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "fast muscle cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000190" ; rdfs:subClassOf obo:CL_0008046, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000858 ] . obo:CL_0000191 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000192 ; a owl:Class ; owl:deprecated true . obo:CL_0000192 obo:IAO_0000115 "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Smooth muscle cells are a specialized type of muscle cells that are primarily found within the walls of hollow organs such as the intestine, stomach, bladder, uterus, and blood vessels. These cells are an essential component of the autonomic nervous system controling involuntary movements within the body. Smooth muscle cells play a vital role in many physiological processes due to their unique functionality. They can contract and relax in a slow, sustained, and controlled manner to help modulate the size and shape of the lumens of the organs they surround. For example, in the digestive system, coordinated contraction and relaxation of smooth muscle cells propels food along the gastrointestinal tract - a process known as peristalsis. In the blood vessels, the smooth muscle cells, by contracting or relaxing, either constrict or dilate the vessels, which in turn, help regulate blood flow and pressure. On a cellular level, smooth muscle cells possess a single, centrally located nucleus and contain an arranged network of actin and myosin filaments, which are the proteins responsible for muscle contraction. Unlike their counterparts in skeletal or cardiac muscles, these cells lack specific contact points for these filaments, hence the lack of visible striations. Furthermore, the contraction of smooth muscle cells is regulated by hormones and neurotransmitters, such as acetylcholine and norepinephrine, adding an additional layer of complex regulation to these highly specialized cells. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasBroadSynonym "non-striated muscle cell" ; oboInOwl:hasDbXref "BTO:0004576", "CALOHA:TS-2159", "FMA:14072", "ZFA:0009118" ; oboInOwl:hasExactSynonym "SMCs", "myocytes, smooth muscle", "smooth muscle fiber" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "smooth muscle cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000192" ; rdfs:subClassOf obo:CL_0008000, obo:CL_0008007, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000514 ] ; skos:prefLabel "smooth muscle cell" . obo:CL_0000193 obo:IAO_0000115 "A striated muscle cell of an arthropod heart that participates in heart contraction." ; a owl:Class ; rdfs:label "cardiac muscle cell (sensu Arthopoda)" ; rdfs:subClassOf obo:CL_0000746, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000465 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000746 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000465 ] ) ] . obo:CL_0000194 a owl:Class ; rdfs:comment "Consider CL:0002072." ; rdfs:label "obsolete nodal cardiac cell" ; owl:deprecated true . obo:CL_0000195 a owl:Class ; rdfs:label "obsolete Purkinje fiber" ; owl:deprecated true . obo:CL_0000196 obo:IAO_0000115 "A muscle cell that is involved in the mechanism of insect flight. This encompasses both, cells that power flight and cells that control flight." ; oboInOwl:hasDbXref "FBbt:00003360" ; a owl:Class ; rdfs:label "insect flight muscle cell" ; rdfs:subClassOf obo:CL_0008003 . obo:CL_0000197 obo:IAO_0000115 "A cell that is capable of detection of a stimulus involved in sensory perception." ; oboInOwl:hasDbXref "MESH:D011984" ; oboInOwl:hasExactSynonym "receptor cell" ; a owl:Class ; rdfs:label "sensory receptor cell" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001032 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050906 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001032 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050906 ] ) ] ; skos:prefLabel "sensory receptor cell" . obo:CL_0000198 obo:IAO_0000115 "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings." ; oboInOwl:hasDbXref "ZFA:0009119" ; oboInOwl:hasExactSynonym "nociceptor", "nocireceptor" ; a owl:Class ; rdfs:comment "Editor note: request detection of stimulus involved in sensory perception of pain; add develops_from relationship" ; rdfs:label "pain receptor cell" ; rdfs:subClassOf obo:CL_0000006 . obo:CL_0000199 obo:IAO_0000115 "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." ; oboInOwl:hasDbXref "ZFA:0009120" ; oboInOwl:hasRelatedSynonym "mechanoreceptor" ; a owl:Class ; rdfs:label "mechanoreceptor cell" ; rdfs:subClassOf obo:CL_0000101, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050974 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050974 ] ) ] . obo:CL_0000200 obo:IAO_0000115 "Any neuron that is capable of some detection of mechanical stimulus involved in sensory perception of touch." ; a owl:Class ; rdfs:label "touch receptor cell" ; rdfs:subClassOf obo:CL_0000199, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050976 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050976 ] ) ] . obo:CL_0000201 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000202 ; a owl:Class ; owl:deprecated true . obo:CL_0000202 obo:IAO_0000115 "A mechanoreceptor cell of the auditory or vestibular system that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." ; oboInOwl:hasDbXref "ZFA:0009121" ; oboInOwl:hasRelatedSynonym "auditory receptor cell" ; a owl:Class ; rdfs:comment "In mammals these cells are located in the organ of Corti." ; rdfs:label "auditory hair cell" ; rdfs:subClassOf obo:CL_0000855, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050910 ] . obo:CL_0000203 obo:IAO_0000115 "Any neuronal receptor cell that is capable of some detection of mechanical stimulus involved in sensory perception of gravity." ; a owl:Class ; rdfs:label "gravity sensitive cell" ; rdfs:subClassOf obo:CL_0000006, obo:CL_0000199, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070999 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000006 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070999 ] ) ] . obo:CL_0000204 a owl:Class ; rdfs:label "acceleration receptive cell" ; rdfs:subClassOf obo:CL_0000006 . obo:CL_0000205 obo:IAO_0000115 "A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain." ; oboInOwl:hasDbXref "ZFA:0009123" ; a owl:Class ; rdfs:label "thermoreceptor cell" ; rdfs:subClassOf obo:CL_0000006, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050960 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000006 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050960 ] ) ] . obo:CL_0000206 obo:IAO_0000115 "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." ; oboInOwl:hasDbXref "ZFA:0009124" ; a owl:Class ; rdfs:label "chemoreceptor cell" ; rdfs:subClassOf obo:CL_0000197, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050907 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000197 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050907 ] ) ] ; skos:prefLabel "chemoreceptor cell" . obo:CL_0000207 obo:IAO_0000115 "Any neuron that is capable of some detection of chemical stimulus involved in sensory perception of smell." ; oboInOwl:hasDbXref "BTO:0004185", "FMA:67860", "MESH:D018034", "Wikipedia:Olfactory_receptor_neuron", "ZFA:0009125" ; oboInOwl:hasExactSynonym "Schultze's cell", "odorant receptor cell", "olfactory receptor neuron", "olfactory sensory neuron" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "olfactory receptor cell" ; rdfs:subClassOf obo:CL_0000006, obo:CL_0000206, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005725 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050911 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050911 ] ) ] ; skos:prefLabel "olfactory receptor cell" . obo:CL_0000208 a owl:Class ; rdfs:label "pH receptor cell" ; rdfs:subClassOf obo:CL_0000206 . obo:CL_0000209 obo:IAO_0000115 "A specialized cell involved in gustatory sensory perception." ; oboInOwl:hasDbXref "FMA:67910", "ZFA:0009126" ; oboInOwl:hasExactSynonym "taste bud cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "taste receptor cell" ; rdfs:subClassOf obo:CL_0000098, obo:CL_0000206, obo:CL_0002076, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050912 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000206 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050912 ] ) ] ; skos:prefLabel "taste receptor cell" . obo:CL_0000210 obo:IAO_0000115 "A cell specialized in detecting light stimuli that are involved in visual perception." ; oboInOwl:hasDbXref "BTO:0001060", "CALOHA:TS-0868", "FBbt:00004211", "FMA:86740", "ZFA:0009127" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "photoreceptor cell" ; rdfs:subClassOf obo:CL_0000101, obo:CL_0008028, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050908 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050908 ] ) ] ; skos:prefLabel "photoreceptor cell" ; foaf:depiction "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg"^^xsd:anyURI . obo:CL_0000211 obo:IAO_0000115 "A cell whose function is determined by the generation or the reception of an electric signal." ; oboInOwl:hasDbXref "ZFA:0009128" ; a owl:Class ; rdfs:label "electrically active cell" ; rdfs:subClassOf obo:CL_0000000 ; skos:prefLabel "electrically active cell" . obo:CL_0000212 obo:IAO_0000115 "OBSOLETE. A cell that takes up and metabolizes substances." ; obo:IAO_0000233 ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "It has no child terms. Consider using 'gut absorptive cell'." ; rdfs:label "obsolete absorptive cell" ; owl:deprecated true . obo:CL_0000213 obo:IAO_0000115 "OBSOLETE. A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." ; obo:IAO_0000233 ; oboInOwl:hasExactSynonym "boundary cell" ; a owl:Class ; rdfs:comment "Obsoleted term because redundant" ; rdfs:label "obsolete lining cell" ; owl:deprecated true . obo:CL_0000214 obo:IAO_0000115 "A cell located in the synovial joint." ; oboInOwl:hasDbXref "CALOHA:TS-0995", "ZFA:0009131" ; oboInOwl:hasExactSynonym "synoviocyte" ; a owl:Class ; rdfs:label "synovial cell" ; rdfs:subClassOf obo:CL_0002078, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002217 ] . obo:CL_0000215 obo:IAO_0000115 "OBSOLETE. A cell whose primary function is to prevent the transport of stuff across compartments." ; obo:IAO_0000233 ; a owl:Class ; rdfs:comment "Not needed term" ; rdfs:label "obsolete barrier cell" ; owl:deprecated true . obo:CL_0000216 obo:IAO_0000115 "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." ; oboInOwl:hasDbXref "BTO:0001238", "CALOHA:TS-0922", "FMA:72298", "VHOG:0001348", "ZFA:0009133" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "Sertoli cell" ; rdfs:subClassOf obo:CL_0000511, obo:CL_0000630, obo:CL_0002625, obo:CL_1100001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000630 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001343 ] ) ] . obo:CL_0000217 obo:IAO_0000233 ; a owl:Class ; rdfs:comment "obsoleted because the term is not needed" ; rdfs:label "obsolete insulating cell" ; owl:deprecated true . obo:CL_0000218 obo:IAO_0000115 "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." ; oboInOwl:hasBroadSynonym "Schwann cell", "peripheral neuroglial cell" ; oboInOwl:hasDbXref "CALOHA:TS-0898", "FMA:62121", "ZFA:0009135" ; oboInOwl:hasExactSynonym "neurilemmal cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "myelinating Schwann cell" ; rdfs:subClassOf obo:CL_0002573, obo:CL_4023154, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002377 ] . obo:CL_0000219 obo:IAO_0000115 "A cell that moves by its own activities." ; oboInOwl:hasDbXref "ZFA:0009136" ; a owl:Class ; rdfs:label "motile cell" ; rdfs:subClassOf obo:CL_0000000, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048870 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048870 ] ) ] ; skos:prefLabel "motile cell" . obo:CL_0000220 oboInOwl:consider "CL:0000000", "CL:0000003", "CL:0001034" ; a owl:Class ; rdfs:comment "This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell in a multicellular organiam, apart from a zygote, can potentially be classified by its lineage. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate." ; rdfs:label "obsolete cell by lineage" ; owl:deprecated true . obo:CL_0000221 obo:IAO_0000115 "A cell of the outer of the three germ layers of the embryo." ; oboInOwl:hasDbXref "FMA:72549", "ZFA:0009137" ; oboInOwl:hasExactSynonym "ectoderm cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "ectodermal cell" ; rdfs:subClassOf obo:CL_0000255, obo:CL_0002321, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000924 ] ; skos:prefLabel "ectodermal cell" . obo:CL_0000222 obo:IAO_0000115 "A cell of the middle germ layer of the embryo." ; terms:description """Mesodermal cells are pluripotent and the most abundant in the human body. They contribute to the development of several structures such as the skeletal muscles, bones, heart and blood vessels, kidneys, gonads, connective tissues, and certain layers of the skin. Hence, the mesoderm is often regarded as an active and diverse layer due to its role in forming many bodily structures. In embryonic development, these cells are instrumental, contributing to the body's structures through a carefully coordinated sequence of morphogenetic movements. This process forms the complex multicellular architecture of tissues and organs from a simple ball of cells. Without the function of mesodermal cells, the body's integral structures and systems would cease to form correctly, leading to developmental disorders such as axial mesodermal dysplasia complex (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:72554", "ZFA:0009138" ; oboInOwl:hasExactSynonym "mesoblast", "mesoderm cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "mesodermal cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000222" ; rdfs:subClassOf obo:CL_0000255, obo:CL_0002321, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000926 ] ; skos:prefLabel "mesodermal cell" . obo:CL_0000223 obo:IAO_0000115 "A cell of the inner of the three germ layers of the embryo." ; oboInOwl:hasDbXref "FMA:72555", "ZFA:0009139" ; oboInOwl:hasExactSynonym "endoderm cell" ; a owl:Class ; rdfs:label "endodermal cell" ; rdfs:subClassOf obo:CL_0000255, obo:CL_0002321, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000925 ] ; skos:prefLabel "endodermal cell" . obo:CL_0000224 obo:IAO_0000115 "OBSOLETE: A classification of cells by the number of their nuclei." ; oboInOwl:consider "CL:0000000", "CL:0000003", "CL:0001034" ; a owl:Class ; rdfs:comment "This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its nuclear number (note that this term was previously used as a parent class of enucleate cell). If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate." ; rdfs:label "obsolete cell by nuclear number" ; owl:deprecated true . obo:CL_0000225 obo:IAO_0000115 "A cell that lacks a nucleus." ; oboInOwl:hasDbXref "FMA:68647" ; oboInOwl:hasExactSynonym "non-nucleated cell" ; a owl:Class ; rdfs:label "anucleate cell" ; rdfs:subClassOf obo:CL_0000000, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001405 ] ; owl:disjointWith obo:CL_0002242 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001405 ] ) ] . obo:CL_0000226 obo:IAO_0000115 "A cell with a single nucleus." ; a owl:Class ; rdfs:label "single nucleate cell" ; rdfs:subClassOf obo:CL_0000255, obo:CL_0002242, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] ) ] . obo:CL_0000227 obo:IAO_0000115 "Any cell that has characteristic some binucleate." ; a owl:Class ; rdfs:label "binucleate cell" ; rdfs:subClassOf obo:CL_0000228, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001406 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001406 ] ) ] . obo:CL_0000228 obo:IAO_0000115 "A cell with more than one nucleus." ; oboInOwl:hasExactSynonym "multinucleated cells", "polynuclear cells" ; a owl:Class ; rdfs:label "multinucleate cell" ; rdfs:subClassOf obo:CL_0000255, obo:CL_0002242, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] ) ] ; skos:prefLabel "multinucleate cell" . obo:CL_0000229 obo:IAO_0000115 "OBSOLETE (was not defined before being made obsolete)." ; a owl:Class ; rdfs:comment "Refers to an activated mature lymphocyte phenotype rather than a distinct cell type; consider using 'lymphocyte ; CL:0000542' or one of its children instead." ; rdfs:label "obsolete lymphoblast" ; owl:deprecated true . obo:CL_0000230 obo:IAO_0000115 "OBSOLETE (was not defined before being made obsolete)." ; a owl:Class ; rdfs:comment "Refers to an activated mature T lymphocyte phenotype rather than a distinct cell type; consider using 'T cell ; CL:0000084' or one of its children instead." ; rdfs:label "obsolete T lymphoblast" ; owl:deprecated true . obo:CL_0000231 obo:IAO_0000115 "OBSOLETE (was not defined before being made obsolete)." ; a owl:Class ; rdfs:comment "Refers to an activated mature B lymphocyte phenotype rather than a distinct cell type; consider using 'B cell ; CL:0000236' or one of its children instead." ; rdfs:label "obsolete B lymphoblast" ; owl:deprecated true . obo:CL_0000232 obo:IAO_0000115 "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000424", "CALOHA:TS-0290", "FMA:81100" ; oboInOwl:hasExactSynonym "RBC", "red blood cell" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "erythrocyte" ; rdfs:subClassOf obo:CL_0000081, obo:CL_0000329, obo:CL_0000764, [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0005840 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001945 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002039 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000558 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000764 [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0005840 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001945 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002039 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0008015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0015671 ] ) ] ; skos:prefLabel "erythrocyte" . obo:CL_0000233 obo:IAO_0000115 "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000132", "CALOHA:TS-0803", "FMA:62851" ; oboInOwl:hasExactSynonym "anucleate thrombocyte", "blood platelet", "enucleate thrombocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF." ; rdfs:label "platelet" ; rdfs:subClassOf obo:CL_0000081, obo:CL_0000225, obo:CL_0000458, obo:CL_0000763, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001874 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000556 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007596 ] . obo:CL_0000234 obo:IAO_0000115 "Any cell capable of ingesting particulate matter via phagocytosis." ; oboInOwl:hasDbXref "BTO:0001044", "FMA:83806", "MESH:D010586", "ZFA:0009140" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "phagocyte" ; rdfs:subClassOf obo:CL_0000219, obo:CL_0000325, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006909 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006909 ] ) ] . obo:CL_0000235 obo:IAO_0000115 "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000801", "CALOHA:TS-0587", "FMA:63261", "FMA:83585", "MESH:D008264", "ZFA:0009141" ; oboInOwl:hasExactSynonym "histiocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid." ; rdfs:label "macrophage" ; rdfs:subClassOf obo:CL_0000113, obo:CL_0000145, obo:CL_0000766, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000576 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0031268 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000766 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002504 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006909 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0031268 ] ) ] . obo:CL_0000236 obo:IAO_0000115 "A lymphocyte of B lineage that is capable of B cell mediated immunity." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000776", "CALOHA:TS-0068", "FMA:62869", "MESH:D001402", "VHOG:0001480", "ZFA:0009142" ; oboInOwl:hasExactSynonym "B lymphocyte", "B-cell", "B-lymphocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "B cell" ; rdfs:subClassOf obo:CL_0000945, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0019724 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000945 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0019724 ] ) ] . obo:CL_0000237 oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "keratinizing barrier epithelial cell" ; rdfs:subClassOf obo:CL_0000240, obo:CL_0000311, obo:CL_0002077, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000114 ] . obo:CL_0000238 a owl:Class ; rdfs:label "non keratinizing barrier epithelial cell" ; rdfs:subClassOf obo:CL_0000240 . obo:CL_0000239 obo:IAO_0000115 "An epithelial cell characterized by the presence of a brush border on its apical surface, which increases the surface area for absorption." ; oboInOwl:hasDbXref , "PMID:25422372", "ZFA:0009143" ; a owl:Class ; rdfs:comment "All brush border cells are columnar-cuboidal. The formal logical definition of this term asserts this. Brush border epithelial cells are predominantly found lining the small intestine and the proximal tubules of the kidneys." ; rdfs:label "brush border epithelial cell" ; rdfs:subClassOf obo:CL_0000075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005903 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005903 ] ) ] . obo:CL_0000240 obo:IAO_0000115 "A stratified epithelial cell that is part of squamous epithelium, characterized by multiple layers of cells. The basal layer is directly attached to the basement membrane and the apical layer consists of flattened squamous cells. This provides a protective barrier, commonly found in areas subject to abrasion, such as the skin, oral cavity, and esophagus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0009144" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "stratified squamous epithelial cell" ; rdfs:subClassOf obo:CL_0000076, obo:CL_0000079, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006915 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000079 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006915 ] ) ] . obo:CL_0000241 obo:IAO_0000115 "A stratified epithelial cell that is part of cuboidal epithelium, characterized by multiple layers of cuboidal cells forming the apical layer. This provides a protective lining for ducts in large glands, such as sweat glands." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0009145" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "stratified cuboidal epithelial cell" ; rdfs:subClassOf obo:CL_0000075, obo:CL_0000079, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010077 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000079 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010077 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" . obo:CL_0000242 obo:IAO_0000115 "A specialized epithelial cell located in the skin epidermis and certain mucosal epithelia. It functions as a mechanoreceptor for light touch by forming synapse-like contacts with somatosensory afferent nerve endings, contributing to slowly adapting type I (SAI) tactile responses. Characterized by dense-core neuroendocrine granules, the Merkel cell exhibits both sensory and neuroendocrine properties, including regulated neurotransmitter release via SNARE complex-dependent mechanisms. Its development in mice depends on the transcription factor Atoh1." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:70548", "ZFA:0009146" ; oboInOwl:hasExactSynonym "Merkel's cell" ; oboInOwl:hasRelatedSynonym "MC" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "Merkel cell" ; rdfs:subClassOf obo:CL_0000123, obo:CL_0000710, obo:CL_1100001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0031201 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007269 ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-epidermal-ridge/v1.2/assets/2d-ftu-skin-epidermal-ridge.png" . obo:CL_0000243 obo:IAO_0000115 "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear." ; obo:IAO_0000233 ; a owl:Class ; rdfs:comment "This is a grouping class that is no longer needed or wanted." ; rdfs:label "obsolete glial cell (sensu Vertebrata)" ; owl:deprecated true . obo:CL_0000244 obo:IAO_0000115 "A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:66778", "ZFA:0009148" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "transitional epithelial cell" ; rdfs:subClassOf obo:CL_0000066 . obo:CL_0000245 obo:IAO_0000115 "Obsolete. Use PO:0000353 from Plant Ontology instead. Cell in exodermis or endodermis that remains thin walled when the associated cells develop thick secondary walls. Has casparian strip in endodermis." ; obo:IAO_0100001 obo:PO_0000353 ; a owl:Class ; rdfs:label "obsolete passage cell" ; owl:deprecated true . obo:CL_0000246 oboInOwl:hasDbXref "ZFA:0009149" ; a owl:Class ; rdfs:label "Mauthner neuron" ; rdfs:subClassOf obo:CL_0000099 . obo:CL_0000247 obo:IAO_0000115 "Type of neuron that is a primary mechanosensory cell, with peripheral neurites innervating the skin with free nerve endings." ; oboInOwl:hasDbXref "AAO:0010316", "EFO:0003711", "VHOG:0001484", "ZFA:0009150" ; oboInOwl:hasExactSynonym "Rohon Beard cell", "Rohon-Beard cell" ; oboInOwl:hasRelatedSynonym "RB neuron" ; a owl:Class ; rdfs:label "Rohon-Beard neuron" ; rdfs:subClassOf obo:CL_0000531 . obo:CL_0000248 obo:IAO_0000115 "Obsolete. Use PO:0020047 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." ; obo:IAO_0100001 obo:PO_0020047 ; oboInOwl:hasExactSynonym "pollen mother cell", "primary sporogenous cell" ; a owl:Class ; rdfs:label "obsolete microsporocyte" ; owl:deprecated true . obo:CL_0000249 oboInOwl:hasDbXref "ZFA:0009151" ; a owl:Class ; rdfs:label "hatching gland cell" ; rdfs:subClassOf obo:CL_0000151 . obo:CL_0000250 obo:IAO_0000115 "Obsolete. Use PO:0020019 from Plant Ontology instead. A haploid (1n) spore developing into a female gametophyte in heterosporous plants." ; obo:IAO_0100001 obo:PO_0020019 ; a owl:Class ; rdfs:label "obsolete megaspore" ; owl:deprecated true . obo:CL_0000251 oboInOwl:hasDbXref "ZFA:0009152" ; a owl:Class ; rdfs:label "extramedullary cell" ; rdfs:subClassOf obo:CL_0000101 . obo:CL_0000252 obo:IAO_0000115 "Obsolete. Use PO:0020048 from Plant Ontology instead. A haploid (1n) spore developing into a male gametophyte in heterosporous plants; the uninucleate pollen grain in seed plants." ; obo:IAO_0100001 obo:PO_0020048 ; a owl:Class ; rdfs:label "obsolete microspore" ; owl:deprecated true . obo:CL_0000253 oboInOwl:hasDbXref "ZFA:0009153" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "eurydendroid cell" ; rdfs:subClassOf obo:CL_0000527 . obo:CL_0000254 obo:IAO_0000115 "Obsolete. Use PO:0020094 from Plant Ontology instead. The female gamete of plants." ; obo:IAO_0100001 obo:PO_0020094 ; oboInOwl:hasExactSynonym "female gametophyte egg cell" ; a owl:Class ; rdfs:label "obsolete egg cell" ; owl:deprecated true . obo:CL_0000255 obo:IAO_0000115 "Any cell that in taxon some Eukaryota." ; oboInOwl:hasDbXref "MESH:D005057" ; a owl:Class ; rdfs:label "eukaryotic cell" ; rdfs:subClassOf obo:CL_0000000, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_2759 ] ; owl:disjointWith obo:CL_0000520 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_2759 ] ) ] ; skos:prefLabel "eukaryotic cell" . obo:CL_0000256 a owl:Class ; rdfs:label "uric acid accumulating cell" ; rdfs:subClassOf obo:CL_0000325 . obo:CL_0000257 obo:IAO_0000115 "Any cell that in taxon some Eumycetozoa." ; a owl:Class ; rdfs:label "Eumycetozoan cell" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_142796 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_142796 ] ) ] . obo:CL_0000258 obo:IAO_0000115 "Obsolete. Use PO:0000355 from Plant Ontology instead. A fiber like tracheid in the secondary xylem; commonly thick walled, with pointed ends and bordered pits that have lenticular to slit like apertures." ; obo:IAO_0100001 obo:PO_0000355 ; a owl:Class ; rdfs:label "obsolete fiber tracheid" ; owl:deprecated true . obo:CL_0000259 obo:IAO_0100001 obo:DDANAT_0000403 ; a owl:Class ; rdfs:label "obsolete aggregate cell" ; owl:deprecated true . obo:CL_0000260 obo:IAO_0000115 "Obsolete. Use PO:0000373 from Plant Ontology instead. Cell containing mucilages or gums or similar carbohydrate material characterized by the property of swelling in water." ; obo:IAO_0100001 obo:PO_0000373 ; a owl:Class ; rdfs:label "obsolete mucilage cell" ; owl:deprecated true . obo:CL_0000261 oboInOwl:consider false, "http://purl.obolibrary.org/obo/DDANAT_0000002"^^xsd:anyURI ; a owl:Class ; rdfs:comment "Obsoleted becuase this term has an overly general name, no definition, and by it's classification appears to refer to a very specific cell type in dictystelium. If needed, the term should be in DDANAT - probably as a subclass of http://purl.obolibrary.org/obo/DDANAT_0000002" ; rdfs:label "obsolete anterior cell" ; owl:deprecated true . obo:CL_0000262 obo:IAO_0000115 "Obsolete. Use PO:0000351 from Plant Ontology instead. An epidermal cell that divides to produce the guard cells." ; obo:IAO_0100001 obo:PO_0000351 ; a owl:Class ; rdfs:label "obsolete guard mother cell" ; owl:deprecated true . obo:CL_0000263 obo:IAO_0100001 obo:DDANAT_0000002 ; a owl:Class ; rdfs:label "obsolete vegetative cell (sensu Mycetozoa)" ; owl:deprecated true . obo:CL_0000264 obo:IAO_0000115 "Obsolete. Use PO:0000400 from Plant Ontology instead. A cambial cell on the phloem side of the cambial zone that is the source of one or more cells arising by periclinal divisions and differentiating into phloem elements with or without additional divisions in various planes." ; obo:IAO_0100001 obo:PO_0000400 ; oboInOwl:hasExactSynonym "phloem mother cell" ; a owl:Class ; rdfs:label "obsolete phloem initial" ; owl:deprecated true . obo:CL_0000265 obo:IAO_0100001 obo:DDANAT_0000404 ; a owl:Class ; rdfs:label "obsolete anterior like cell" ; owl:deprecated true . obo:CL_0000266 obo:IAO_0000115 "Obsolete. Use PO:0004011 from Plant Ontology instead. A cell constituting an active locus of meristematic activity in a tissue composed of somewhat older, differentiating cells." ; obo:IAO_0100001 obo:PO_0004011 ; a owl:Class ; rdfs:label "obsolete meristemoid" ; owl:deprecated true . obo:CL_0000267 obo:IAO_0100001 obo:DDANAT_0000405 ; a owl:Class ; rdfs:label "obsolete prespore cell" ; owl:deprecated true . obo:CL_0000268 obo:IAO_0000115 "Obsolete. Consult Plant Ontology instead. The cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. Classified into sieve cell and sieve tube member." ; a owl:Class ; rdfs:label "obsolete sieve element" ; owl:deprecated true . obo:CL_0000269 obo:IAO_0100001 obo:DDANAT_0000406 ; a owl:Class ; rdfs:label "obsolete prestalk cell" ; owl:deprecated true . obo:CL_0000270 obo:IAO_0000115 "Obsolete. Use PO:0000284 from Plant Ontology instead. An epidermal cell associated with a stoma and at least morphologically distinguishable from the epidermal cells composing the groundmass of the tissue." ; obo:IAO_0100001 obo:PO_0000284 ; a owl:Class ; rdfs:label "obsolete subsidiary cell" ; owl:deprecated true . obo:CL_0000271 obo:IAO_0100001 obo:DDANAT_0000408 ; a owl:Class ; rdfs:label "obsolete prestalk A cell" ; owl:deprecated true . obo:CL_0000272 obo:IAO_0000115 "OBSOLETE, use term from Plant Ontology. A cell localized in the vascular cambium or phellogen. Its periclinal division can contribute cells either to the outside or to the inside of the axis; in vascular cambium, classified into fusiform initials (source of axial cells of xylem and phloem) and ray initials (source of the ray cells)." ; a owl:Class ; rdfs:comment "replaced_by PO:0000295" ; rdfs:label "obsolete cambial initial" ; owl:deprecated true . obo:CL_0000273 obo:IAO_0100001 obo:DDANAT_0000410 ; a owl:Class ; rdfs:label "obsolete prestalk AB cell" ; owl:deprecated true . obo:CL_0000274 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000009 ; a owl:Class ; owl:deprecated true . obo:CL_0000275 obo:IAO_0100001 obo:DDANAT_0000409 ; a owl:Class ; rdfs:label "obsolete prestalk B cell" ; owl:deprecated true . obo:CL_0000276 obo:IAO_0000115 "Obsolete. Use PO:0000077 from Plant Ontology instead. Cell variable in form and size, being more or less thick, often lignified, secondary walls. Belongs to the category of subcells and may or may not be devoid of protoplast at maturity." ; obo:IAO_0100001 obo:PO_0000077 ; a owl:Class ; rdfs:label "obsolete sclerenchyma cell" ; owl:deprecated true . obo:CL_0000277 obo:IAO_0000115 "OBSOLETE: Initial population of prestalk cells that activate the ecmA promoter at the mound stage and that presumably further differentiate into pstA and pstO cells." ; obo:IAO_0100001 obo:DDANAT_0000406 ; a owl:Class ; rdfs:comment "This cell type does not exist in Dictyostelium. it has been long deleted in their anatomy ontology." ; rdfs:label "obsolete prestalk I cell" ; owl:deprecated true . obo:CL_0000278 obo:IAO_0000115 "Obsolete. Use PO:0020090 from Plant Ontology instead. OBSOLETED, use term from Plant Ontology. A cell containing the two polar nuclei which, after double fertilization, will develop into the endosperm." ; obo:IAO_0100001 obo:PO_0020090 ; a owl:Class ; rdfs:label "obsolete central cell" ; owl:deprecated true . obo:CL_0000279 obo:IAO_0100001 obo:DDANAT_0000407 ; a owl:Class ; rdfs:label "obsolete prestalk 0 cell" ; owl:deprecated true . obo:CL_0000280 obo:IAO_0000115 "Obsolete. Use PO:0020097 from Plant Ontology instead. The cell that will give rise to the generative nuclei which will participate in fertilization." ; obo:IAO_0100001 obo:PO_0020097 ; a owl:Class ; rdfs:label "obsolete generative cell" ; owl:deprecated true . obo:CL_0000281 obo:IAO_0100001 obo:DDANAT_0000411 ; a owl:Class ; rdfs:label "obsolete pstAB/ALC" ; owl:deprecated true . obo:CL_0000282 obo:IAO_0000115 "Obsolete. Use PO:0000282 from Plant Ontology instead. An outgrowth from the epidermis. Trichomes vary in size and complexity and include hairs, scales, and other structures and may be glandular. In Arabidopsis, patterning of trichome development is not random but does not appear to be lineage-based like stomata." ; obo:IAO_0100001 obo:PO_0000282 ; a owl:Class ; rdfs:label "obsolete trichome" ; owl:deprecated true . obo:CL_0000283 obo:IAO_0100001 obo:DDANAT_0000412 ; a owl:Class ; rdfs:label "obsolete pstO/ALC" ; owl:deprecated true . obo:CL_0000284 obo:IAO_0000115 "Obsolete. Use PO:0000071 from Plant Ontology instead. A specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." ; obo:IAO_0100001 obo:PO_0000071 ; a owl:Class ; rdfs:label "obsolete companion cell" ; owl:deprecated true . obo:CL_0000285 obo:IAO_0100001 obo:DDANAT_0000413 ; a owl:Class ; rdfs:label "obsolete stalk cell" ; owl:deprecated true . obo:CL_0000286 obo:IAO_0000115 "A cell of a filament of a fungal mycelium." ; a owl:Class ; rdfs:label "hyphal cell" ; rdfs:subClassOf obo:CL_0000521 . obo:CL_0000287 obo:IAO_0000115 "Any photoreceptor cell that is part of some eye." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0009154" ; oboInOwl:inSubset cl:cellxgene_subset, cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "eye photoreceptor cell" ; rdfs:subClassOf obo:CL_0000006, obo:CL_0000210, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000970 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000210 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000970 ] ) ] ; skos:prefLabel "eye photoreceptor cell" . obo:CL_0000288 obo:IAO_0000115 "Obsolete. Use PO:0000191 from Plant Ontology instead. A cell in the micropylar end of the embryo sac associated with the egg in the egg apparatus of angiosperms. Plays a vital role in fertilization." ; obo:IAO_0100001 obo:PO_0000191 ; a owl:Class ; rdfs:label "obsolete synergid" ; owl:deprecated true . obo:CL_0000289 obo:IAO_0100001 obo:DDANAT_0000402 ; a owl:Class ; rdfs:label "obsolete chemotactic amoeboid cell (sensu Mycetozoa)" ; owl:deprecated true . obo:CL_0000290 obo:IAO_0000115 "Obsolete. Use PO:0000274 from Plant Ontology instead. A fiber of the xylem tissue, Two types are recognized in the secondary xylem: fiber tracheids and libriform fibers." ; obo:IAO_0100001 obo:PO_0000274 ; a owl:Class ; rdfs:label "obsolete xylem fiber cell" ; owl:deprecated true . obo:CL_0000291 obo:IAO_0100001 obo:DDANAT_0000414 ; a owl:Class ; rdfs:label "obsolete spore (sensu Mycetozoa)" ; owl:deprecated true . obo:CL_0000292 obo:IAO_0000115 "Obsolete. Use PO:0000293 from Plant Ontology instead. One of a pair of cells flanking the stomatal pore and causing the opening and closing of the pore by changes in turgor." ; obo:IAO_0100001 obo:PO_0000293 ; oboInOwl:hasExactSynonym "stomatal guard cell" ; a owl:Class ; rdfs:label "obsolete guard cell" ; owl:deprecated true . obo:CL_0000293 obo:IAO_0000115 "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." ; oboInOwl:hasDbXref "ZFA:0005745" ; a owl:Class ; rdfs:label "structural cell" ; rdfs:subClassOf obo:CL_0000000 ; skos:prefLabel "structural cell" . obo:CL_0000294 obo:IAO_0000115 "Obsolete. Consult Plant Ontology instead. A type of sieve element that has relatively undifferentiated sieve areas (with narrow pores), rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants." ; a owl:Class ; rdfs:label "obsolete sieve cell" ; owl:deprecated true . obo:CL_0000295 obo:IAO_0000115 "A peptide hormone secreting cell that produces growth hormone, somatotropin." ; oboInOwl:hasDbXref "ZFA:0009155" ; oboInOwl:hasExactSynonym "growth hormone secreting cell", "somatotrophin secreting cell" ; a owl:Class ; rdfs:label "somatotropin secreting cell" ; rdfs:subClassOf obo:CL_0000167, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030252 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030252 ] ) ] ; skos:prefLabel "somatotropin secreting cell" . obo:CL_0000296 obo:IAO_0000115 "Obsolete. Use PO:0020099 from Plant Ontology instead. Cell type formed after the first mitotic division of the microgametophye, The nucleus of this cell migrates to the tip of the pollen tube after germination and disintegrates when the pollen tube penetrates the nucellus." ; obo:IAO_0100001 obo:PO_0020099 ; a owl:Class ; rdfs:label "obsolete vegetative cell" ; owl:deprecated true . obo:CL_0000297 obo:IAO_0000115 "Obsolete. Use PO:0000115 from Plant Ontology instead. A cell that surrounds a trichome and provides support for the trichome." ; obo:IAO_0100001 obo:PO_0000115 ; a owl:Class ; rdfs:label "obsolete socket cell" ; owl:deprecated true . obo:CL_0000298 obo:IAO_0000115 "Obsolete. Use PO:0000273 from Plant Ontology instead. A cell composing the xylem." ; obo:IAO_0100001 obo:PO_0000273 ; a owl:Class ; rdfs:label "obsolete xylem element" ; owl:deprecated true . obo:CL_0000299 obo:IAO_0000115 "OBSOLETED. Commonly used for a cell in root epidermis that gives rise to a root hair. The daughter cell produced by the asymmetric division of a root epidermal cell that gives rise to a root hair." ; a owl:Class ; rdfs:comment "Obsoleted. Use trichoblast from the plant ontology (PO:0000262)." ; rdfs:label "obsolete trichoblast" ; owl:deprecated true . obo:CL_0000300 obo:IAO_0000115 "A mature sexual reproductive cell having a single set of unpaired chromosomes." ; terms:description """Gametes are reproductive cells essential for sexual reproduction in eukaryotic organisms, including humans, animals, and many plants. These cells are haploid, containing half the genome or only one set of chromosomes, which is a contrast to the diploid state (two sets of chromosomes) found in most cells in a multicellular organism. This reduction in genetic material is crucial since it allows for the re-establishment of the diploid number of chromosomes when two gametes merge to form a diploid zygote during fertilization. There are two major types of gametes in animals: sperm cells in males and egg (or ova) in females. These gametes contribute equally to the genetic makeup of the offspring but are morphologically and functionally distinct. Sperm cells (or spermatozoa) are characterized by their motility, small size, and large quantities; they are produced continuously in vast numbers through a process called spermatogenesis in the male gonads or testes. Female gametes are much larger, fewer in numbers, and are not motile; they undergo a development process known as oogenesis, which takes place within the ovaries. The egg also contributes most of the cytoplasm and organelles (including mitochondria) to the zygote that are required for initial cell division stages after fertilization. Gametes have a primary role in sexual reproduction and genetic variation, which aids in evolution. The formation of gametes involves a special type of cell division called meiosis that introduces genetic diversity via the process of recombination and independent assortment. Following the fusion of male and female gametes, the combination of paternal and maternal genetic material in the zygote allows for genetic recombination, which is a fundamental source of genetic variation and, thus, evolution. Therefore, gametes not only are critical to the inception of new individuals but also contribute to species survival and evolution. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "CALOHA:TS-0395", "FBbt:00005412", "FMA:18649", "ZFA:0009156" ; oboInOwl:hasExactSynonym "haploid nucleated cell" ; oboInOwl:hasRelatedSynonym "haploid germ cell" ; a owl:Class ; rdfs:label "gamete" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000300" ; rdfs:subClassOf obo:CL_0000413, obo:CL_0000586, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0009566 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001375 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0009566 ] ) ] . obo:CL_0000301 obo:IAO_0000115 "A primordial germ cell of insects. Such cells form at the posterior pole of the early embryo." ; oboInOwl:hasDbXref "FBbt:00000092" ; a owl:Class ; rdfs:label "pole cell" ; rdfs:subClassOf obo:CL_0000670 . obo:CL_0000302 obo:IAO_0000115 "OBSOLETE (was not defined before being made obsolete)." ; a owl:Class ; rdfs:comment "Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead." ; rdfs:label "obsolete IgM B cell" ; owl:deprecated true . obo:CL_0000303 obo:IAO_0000115 "OBSOLETE (was not defined before being made obsolete)." ; a owl:Class ; rdfs:comment "Not a differentiation state per se, and IgG isotypes vary by species; consider using 'B cell ; CL:0000236' or one of its children instead." ; rdfs:label "obsolete IgG B cell" ; owl:deprecated true . obo:CL_0000304 obo:IAO_0000115 "OBSOLETE (was not defined before being made obsolete)." ; a owl:Class ; rdfs:comment "Not a differentiation state per se, and IgA isotypes vary by species. Consider using 'B cell ; CL:0000236' or one of its children instead." ; rdfs:label "obsolete IgA B cell" ; owl:deprecated true . obo:CL_0000305 obo:IAO_0000115 "OBSOLETE (was not defined before being made obsolete)." ; a owl:Class ; rdfs:comment "Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead." ; rdfs:label "obsolete IgE B cell" ; owl:deprecated true . obo:CL_0000306 oboInOwl:hasExactSynonym "lens cell" ; oboInOwl:inSubset cl:eye_upper_slim ; a owl:Class ; rdfs:label "crystallin accumulating cell" ; rdfs:subClassOf obo:CL_0000325 . obo:CL_0000307 obo:IAO_0000115 "An epithelial cell found in the trachea." ; oboInOwl:hasDbXref "FMA:74793" ; oboInOwl:hasExactSynonym "tracheocyte" ; a owl:Class ; rdfs:comment "This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell'" ; rdfs:label "tracheal epithelial cell" ; rdfs:subClassOf obo:CL_0002202, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000377 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] . obo:CL_0000308 a owl:Class ; rdfs:label "metal ion accumulating cell" ; rdfs:subClassOf obo:CL_0000325 . obo:CL_0000309 oboInOwl:hasExactSynonym "cuprophilic cell" ; a owl:Class ; rdfs:label "copper accumulating cell" ; rdfs:subClassOf obo:CL_0000308 . obo:CL_0000310 a owl:Class ; rdfs:label "iron accumulating cell" ; rdfs:subClassOf obo:CL_0000308 . obo:CL_0000311 oboInOwl:hasDbXref "ZFA:0009157" ; a owl:Class ; rdfs:label "keratin accumulating cell" ; rdfs:subClassOf obo:CL_0000325 . obo:CL_0000312 obo:IAO_0000115 "An epithelial cell of stratified squamous tissues, including skin, oral mucosa (Hiroshima et al., 2011), and esophagus (Whelan et al., 2018), that produces keratin proteins and secretes antimicrobial peptides to form a resilient barrier against environmental damage, dehydration, pathogens, and microbial invasion. It undergoes successive stages of differentiation marked by changes in keratin expression, supporting tissue integrity, wound repair, and contributing to immune defense." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000667", "CALOHA:TS-0500", "FMA:62879", "ZFA:0009158" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "keratinocyte" ; rdfs:subClassOf obo:CL_0000237, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002775 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002776 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042060 ] . obo:CL_0000313 obo:IAO_0000115 "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." ; oboInOwl:hasDbXref "BTO:0003687", "FMA:62511" ; oboInOwl:hasExactSynonym "serous cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "serous secreting cell" ; rdfs:subClassOf obo:CL_0000159 . obo:CL_0000314 a owl:Class ; rdfs:label "milk secreting cell" ; rdfs:subClassOf obo:CL_0000151 . obo:CL_0000315 obo:IAO_0000115 "A cell secreting tears, the fluid secreted by the lacrimal glands. This fluid moistens the conjunctiva and cornea." ; oboInOwl:hasExactSynonym "tears secreting cell" ; a owl:Class ; rdfs:label "tear secreting cell" ; rdfs:subClassOf obo:CL_0000152, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001817 ] . obo:CL_0000316 obo:IAO_0000115 "Obsolete. Use PO:0000082 from Plant Ontology instead. A meristemic ray cell in the vascular cambium that gives rise to ray cells of the secondary xylem and secondary phloem." ; obo:IAO_0100001 obo:PO_0000082 ; a owl:Class ; rdfs:label "obsolete ray initial" ; owl:deprecated true . obo:CL_0000317 obo:IAO_0000115 "An epithelial cell that is part of a sebaceous gland. This cell produces and secretes sebum, an oily, lipid-rich substance, through holocrine secretion where the entire cell ruptures to release its contents." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "sebum secreting cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "sebocyte" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000152, obo:CL_0000362, obo:CL_0002308, obo:CL_2000021 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001821 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-hair-follicle/v1.0/assets/2d-ftu-skin-hair-follicle.png" . obo:CL_0000318 obo:IAO_0000115 "A cell secreting sweat, the fluid excreted by the sweat glands of mammals. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products." ; a owl:Class ; rdfs:label "sweat secreting cell" ; rdfs:subClassOf obo:CL_0000150 . obo:CL_0000319 obo:IAO_0000115 "Any cell that is capable of some mucus secretion." ; oboInOwl:hasDbXref "BTO:0003689", "ZFA:0009159" ; oboInOwl:hasExactSynonym "mucous cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "mucus secreting cell" ; rdfs:subClassOf obo:CL_0000159, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070254 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070254 ] ) ] . obo:CL_0000320 obo:IAO_0000115 "Obsolete. Use PO:0000431 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and produces four haploid (1n) megaspores; also called megaspore mother cell." ; obo:IAO_0100001 obo:PO_0000431 ; oboInOwl:hasExactSynonym "archesporial cell", "megaspore mother cell" ; a owl:Class ; rdfs:label "obsolete megasporocyte" ; owl:deprecated true . obo:CL_0000321 obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000151 ; oboInOwl:consider obo:CL_1001597 ; a owl:Class ; rdfs:label "obsolete seminal fluid secreting cell" ; owl:deprecated true . obo:CL_0000322 obo:IAO_0000115 "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." ; terms:contributor ; terms:date "2024-09-02T08:27:21Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0000395", "CALOHA:TS-2168", "FMA:62499", "MESH:D056809" ; oboInOwl:hasExactSynonym "alveolar epithelial cell", "alveolus of lung epithelial cell", "epithelial cell of alveolus of lung", "pneumocyte", "pneumonocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "pulmonary alveolar epithelial cell" ; rdfs:subClassOf obo:CL_0000082, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004821 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004821 ] ) ] . obo:CL_0000323 a owl:Class ; rdfs:label "lysozyme secreting cell" ; rdfs:subClassOf obo:CL_0000154 . obo:CL_0000324 oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "metanephric mesenchyme stem cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000134, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000222 ] . obo:CL_0000325 obo:IAO_0000115 "A cell that is specialised to accumulate a particular substance(s)." ; oboInOwl:inSubset ubprop:_upper_level ; a owl:Class ; rdfs:label "stuff accumulating cell" ; rdfs:subClassOf obo:CL_0000000 ; skos:prefLabel "stuff accumulating cell" . obo:CL_0000326 a owl:Class ; rdfs:label "glycogen accumulating cell" ; rdfs:subClassOf obo:CL_0000325 . obo:CL_0000327 oboInOwl:hasDbXref "ZFA:0009162" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "extracellular matrix secreting cell" ; rdfs:subClassOf obo:CL_0000499 ; skos:prefLabel "extracellular matrix secreting cell" . obo:CL_0000328 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_4023154 ; a owl:Class ; rdfs:comment "see: https://github.com/obophenotype/cell-ontology/issues/161" ; rdfs:label "obsolete myelin accumulating cell" ; owl:deprecated true . obo:CL_0000329 obo:IAO_0000115 "Any cell that is capable of some oxygen transport." ; oboInOwl:hasDbXref "ZFA:0009164" ; a owl:Class ; rdfs:label "oxygen accumulating cell" ; rdfs:subClassOf obo:CL_0000000, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0015671 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0015671 ] ) ] ; skos:prefLabel "oxygen accumulating cell" . obo:CL_0000330 obo:IAO_0000115 "Obsolete. Use PO:0000075 from Plant Ontology instead. An elongated living cell with unevenly thickened nonlignified primary walls." ; obo:IAO_0100001 obo:PO_0000075 ; a owl:Class ; rdfs:label "obsolete collenchymal cell" ; owl:deprecated true . obo:CL_0000331 obo:IAO_0000115 "Obsolete. Use PO:0000301 from Plant Ontology instead. A tracheary element of the xylem that has no perforations, as contrasted with a vessel member. May occur in primary and in secondary xylem. May have any kind of secondary wall thickening found in tracheary elements." ; obo:IAO_0100001 obo:PO_0000301 ; a owl:Class ; rdfs:label "obsolete tracheid" ; owl:deprecated true . obo:CL_0000332 obo:IAO_0000115 "OBSOLETE, use term from Plant Ontology. A cell formed after asymmetric division of root epidermal cell that does not give rise to a root hair." ; obo:IAO_0100001 obo:PO_0020090 ; oboInOwl:hasRelatedSynonym "non-hair cell" ; a owl:Class ; rdfs:label "obsolete atrichoblast" ; owl:deprecated true . obo:CL_0000333 obo:IAO_0000115 "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." ; oboInOwl:hasDbXref "FMA:86667", "ZFA:0007086" ; a owl:Class ; rdfs:label "migratory neural crest cell" ; rdfs:subClassOf obo:CL_0000219, obo:CL_0011012, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0007004 ] ; skos:prefLabel "migratory neural crest cell" . obo:CL_0000334 oboInOwl:hasDbXref "BTO:0002307", "FAO:0000032" ; oboInOwl:hasRelatedSynonym "yeast-form" ; a owl:Class ; rdfs:label "vegetative cell (sensu Fungi)" ; rdfs:subClassOf obo:CL_0000521 . obo:CL_0000335 obo:IAO_0000115 "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." ; oboInOwl:hasDbXref "ZFA:0009166" ; a owl:Class ; rdfs:label "mesenchyme condensation cell" ; rdfs:subClassOf obo:CL_0008019 ; skos:prefLabel "mesenchyme condensation cell" . obo:CL_0000336 obo:IAO_0000115 "A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation." ; oboInOwl:hasDbXref "FMA:69262", "ZFA:0009167" ; oboInOwl:hasExactSynonym "medullary chromaffin cell of adrenal gland" ; a owl:Class ; rdfs:label "adrenal medulla chromaffin cell" ; rdfs:subClassOf obo:CL_0000457, obo:CL_1000426, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001236 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000011 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001236 ] ) ] . obo:CL_0000337 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000031 ; a owl:Class ; owl:deprecated true . obo:CL_0000338 obo:IAO_0000115 "A neural precursor of the central nervous system." ; oboInOwl:hasBroadSynonym "neuroblast" ; oboInOwl:hasDbXref "FBbt:00005146" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "neuroblast (sensu Nematoda and Protostomia)" ; rdfs:subClassOf obo:CL_0000047, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_33317 ] . obo:CL_0000339 obo:IAO_0000115 "An early neural cell developing from the early ependymal cell of the neural tube." ; oboInOwl:hasDbXref "FMA:70564", "ZFA:0009169" ; oboInOwl:hasExactSynonym "spongioblast" ; a owl:Class ; rdfs:label "glioblast (sensu Vertebrata)" ; rdfs:subClassOf obo:CL_0000030, obo:CL_0000123 . obo:CL_0000340 obo:IAO_0000115 "A precursor of the central nervous system that gives rise to glial cells only." ; oboInOwl:hasDbXref "FBbt:00005145" ; a owl:Class ; rdfs:label "glioblast (sensu Nematoda and Protostomia)" ; rdfs:subClassOf obo:CL_0000030, obo:CL_0000130 . obo:CL_0000341 obo:RO_0002161 obo:NCBITaxon_33511 ; a owl:Class ; rdfs:label "pigment cell (sensu Nematoda and Protostomia)" ; rdfs:subClassOf obo:CL_0000147 . obo:CL_0000342 obo:IAO_0000115 "Any animal cell containing pigment granules." ; oboInOwl:hasDbXref "ZFA:0009170" ; a owl:Class ; rdfs:label "pigment cell (sensu Vertebrata)" ; rdfs:subClassOf obo:CL_0000147, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_7742 ] . obo:CL_0000343 obo:IAO_0000115 "A pigment cell that is capable of detecting light stimulus that is involved in visual perception." ; oboInOwl:hasDbXref "FMA:63846", "ZFA:0009171" ; a owl:Class ; rdfs:label "visual pigment cell (sensu Vertebrata)" ; rdfs:subClassOf obo:CL_0000149, obo:CL_0000342, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050908 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000342 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050908 ] ) ] . obo:CL_0000344 a owl:Class ; rdfs:label "obsolete non-visual cell (sensu Vertebrata)" ; owl:deprecated true . obo:CL_0000345 obo:IAO_0000115 "A mesenchymal cell that is part of a small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp." ; oboInOwl:hasDbXref "ZFA:0009173" ; a owl:Class ; rdfs:comment "Merge with odontoblast?" ; rdfs:label "dental papilla cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0008019, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001763 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000008 ] . obo:CL_0000346 obo:IAO_0000115 "A specialized mesenchymal cell that resides in the dermal papilla located at the bottom of hair follicles. This cell plays a pivotal roles in hair formation, growth, and cycling." ; a owl:Class ; rdfs:comment "Are these really all stem cells?" ; rdfs:label "hair follicle dermal papilla cell" ; rdfs:subClassOf obo:CL_0000134, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000412 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000412 ] ) ] . obo:CL_0000347 obo:IAO_0000115 "A cell of the sclera of the eye." ; oboInOwl:hasDbXref "ZFA:0009174" ; oboInOwl:inSubset cl:eye_upper_slim ; a owl:Class ; rdfs:label "scleral cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000255, obo:CL_0000293, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001773 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000008 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000293 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001773 ] ) ] ; skos:prefLabel "scleral cell" . obo:CL_0000348 obo:IAO_0000115 "A structural cell that is part of optic choroid." ; oboInOwl:hasDbXref "ZFA:0009175" ; oboInOwl:inSubset cl:eye_upper_slim ; a owl:Class ; rdfs:label "choroidal cell of the eye" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000255, obo:CL_0000293, _:genid1645, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000008 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000293 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001776 ] ) ] . obo:CL_0000349 obo:IAO_0000115 "Any cell that is part of some extraembryonic structure." ; oboInOwl:hasDbXref "ZFA:0009176" ; oboInOwl:inSubset cl:cellxgene_subset, cl:general_cell_types_upper_slim ; a owl:Class ; rdfs:label "extraembryonic cell" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000478 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000478 ] ) ] . obo:CL_0000350 obo:IAO_0000115 "Any extraembryonic cell that is part of some amnioserosa." ; a owl:Class ; rdfs:label "amnioserosal cell" ; rdfs:subClassOf obo:CL_0000349, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010302 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000349 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010302 ] ) ] . obo:CL_0000351 obo:IAO_0000115 "An extraembryonic cell that develops from a trophectodermal cell. This cell is found in the outer layer of the blastocyst and can invade other structures in the uterus once the blastocyst implants into the uterine wall. A trophoblast cell is involved in the implantation of the embryo into the uterine wall, placental formation, remodelling of maternal vasculature in the uterus, nutrient and gas exchange, hormone production, and immune modulation to support fetal development." ; terms:description """Trophoblast cells, originating from the blastocyst's outer layer, are highly specialized and pivotal for embryo development. Their crucial roles include facilitating implantation and contributing to the formation of the placenta, an essential organ for fetal nutrition, gas exchange, and waste removal during pregnancy. These cells play a crucial role in implantation by adhering to the uterus lining. Post-implantation, some trophoblast cells differentiate, forming syncytiotrophoblasts. These multi-nucleated cells absorb nutrients, release waste, and secrete hormones, including human chorionic gonadotropin (hCG), sustaining pregnancy. Trophoblast cells also play a crucial role in immune tolerance, preventing the maternal immune system from treating the fetus as foreign. This balance is vital for a healthy pregnancy. Dysfunctional trophoblast cells may lead to complications like miscarriages or preeclampsia, emphasizing their importance in both embryology and reproductive medicine. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:83028" ; oboInOwl:hasExactSynonym "trophoblastic cell" ; a owl:Class ; rdfs:label "trophoblast cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000351" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000349, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_1000274 ] . obo:CL_0000352 obo:IAO_0000115 "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." ; a owl:Class ; rdfs:label "epiblast cell" ; rdfs:subClassOf obo:CL_0000052 ; skos:prefLabel "epiblast cell" . obo:CL_0000353 obo:IAO_0000115 "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." ; oboInOwl:hasDbXref "BTO:0001473", "FMA:72551", "ZFA:0009177" ; oboInOwl:hasExactSynonym "blastomere" ; a owl:Class ; rdfs:label "blastoderm cell" ; rdfs:subClassOf obo:CL_0000007 . obo:CL_0000354 oboInOwl:hasDbXref "ZFA:0009178", "ncithesaurus:Blastemal_Cell" ; oboInOwl:hasExactSynonym "blastema cell" ; a owl:Class ; rdfs:label "blastemal cell" ; rdfs:subClassOf obo:CL_0000048 . obo:CL_0000355 obo:IAO_0000115 "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." ; oboInOwl:hasDbXref "FMA:86767", "ZFA:0009179" ; a owl:Class ; rdfs:comment "Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo." ; rdfs:label "multi-potent skeletal muscle stem cell" ; rdfs:subClassOf obo:CL_0000048, obo:CL_0000188 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000048 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001134 ] ) ] ; skos:prefLabel "multi-potent skeletal muscle stem cell" . obo:CL_0000356 a owl:Class ; rdfs:label "hair matrix stem cell" ; rdfs:subClassOf obo:CL_0000035 . obo:CL_0000357 oboInOwl:hasDbXref "ZFA:0009180" ; a owl:Class ; rdfs:label "stratified epithelial stem cell" ; rdfs:subClassOf obo:CL_0000036 . obo:CL_0000358 obo:IAO_0000115 "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." ; terms:description """Smooth muscle cells, as a broader category, are non-striated, involuntary muscle cells that usually exhibit contractions and dilation to facilitate numerous physiological functions. Sphincter associated smooth muscle cells are a specific type of smooth muscle cell that are primarily associated with the functioning of various anatomical sphincters in the human body. The traits that distinguishes sphincter associated smooth muscle cells from other smooth muscle cells are their location and specialized function in sphincter mechanisms. Sphincter associated smooth muscle cells play a pivotal role in regulating the opening and closure of the bodily sphincters. These sphincters can be found at multiple locations within the body including the gastrointestinal tract (namely the esophagus, stomach, small intestine, and rectum), the urinary tract, and the circulatory system. Upon receiving signals from the autonomous nervous system, these cells contract or relax to modulate the aperture of sphincters, thus controlling the movement of substances through them. Due to their precise and vital functional role, any dysfunction or dysregulation in these cells can lead to serious medical conditions, such as gastroesophageal reflux or urinary incontinence. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; a owl:Class ; rdfs:label "sphincter associated smooth muscle cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000358" ; rdfs:subClassOf obo:CL_0000192, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004590 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004590 ] ) ] . obo:CL_0000359 obo:IAO_0000115 "A smooth muscle cell associated with the vasculature." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Vascular associated smooth muscle cells (VSMCs) are specialized cells that constitute a major component of the blood vessel wall in the circulatory system. They derive their name from the predominantly smooth appearance under microscopic examination, as opposed to the striated appearance of cardiac and skeletal muscles. A principal function of VSMCs is to regulate vascular tone, which directly dictates blood pressure and blood flow distribution across various body parts. This is achieved through coordinated contraction and relaxation of the muscles in response to a variety of extracellular signals. When a blood vessel is exposed to stimuli like pressure or injury, VSMCs contract, resulting in vasoconstriction and ultimately, an increase in blood pressure. Conversely, in response to vasodilators, these cells relax, leading to vasodilation and a consequent decrease in blood pressure. VSMCs are also involved in vascular remodeling, a process where blood vessels adapt their structure to long-term changes in hemodynamic conditions or disease states. In diseases like atherosclerosis and hypertension, an aberrant proliferative and synthetic phenotype of VSMCs contributes to the formation of plaques, leading to vessel hardening or even occlusion. Recent research has further implicated these cells in immune responses, recognizing their function in leukocyte recruitment and inflammation, factors that are largely instrumental in vascular pathologies. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "ZFA:0009181" ; oboInOwl:hasExactSynonym "VSMC", "vascular smooth muscle cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "vascular associated smooth muscle cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000359" ; rdfs:subClassOf obo:CL_0000192, obo:CL_4033054, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002049 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002049 ] ) ] . obo:CL_0000360 obo:IAO_0000115 "A cell of the early embryo at the developmental stage in which the blastomeres, resulting from repeated mitotic divisions of the fertilized ovum (zygote), form a compact cell mass." ; a owl:Class ; rdfs:label "morula cell" ; rdfs:subClassOf obo:CL_0000007, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000085 ] . obo:CL_0000361 obo:IAO_0000115 "A cell of the embryo in the early stage following the blastula, characterized by morphogenetic cell movements, cell differentiation, and the formation of the three germ layers." ; oboInOwl:hasDbXref "ZFA:0009182" ; a owl:Class ; rdfs:label "gastrula cell" ; rdfs:subClassOf obo:CL_0000007, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004734 ] . obo:CL_0000362 obo:IAO_0000115 "An epithelial cell of the integument (the outer layer of an organism)." ; oboInOwl:hasDbXref "BTO:0001470", "CALOHA:TS-0283", "FMA:62411", "MESH:D000078404", "ZFA:0009183" ; oboInOwl:hasExactSynonym "cell of epidermis" ; oboInOwl:hasNarrowSynonym "epithelial cell of skin" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "epidermal cell" ; rdfs:subClassOf obo:CL_0002159, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007376 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007376 ] ) ] . obo:CL_0000363 obo:IAO_0000115 "Obsolete. Use PO:0000081 from Plant Ontology instead. OBSOLETE, use term from the Plant Ontology. A secondary vascular cell that develops from the fusiform cambial initials and oriented with their longest diameter parallel with the main axis of stem or root. These cells make up the axial system, also known as vertical or longitudinal system." ; obo:IAO_0100001 obo:PO_0000081 ; a owl:Class ; rdfs:label "obsolete axial cell" ; owl:deprecated true . obo:CL_0000364 obo:IAO_0000115 "Obsolete. Consult Plant Ontology. A cell that develops from the ray initial and composes all rays (panels of tissue variable in height and width, formed by the ray initials in the vascular cambium and extending radially in the secondary xylem and secondary phloem) in the secondary vascular tissues." ; a owl:Class ; rdfs:label "obsolete ray cell" ; owl:deprecated true . obo:CL_0000365 obo:IAO_0000115 "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." ; oboInOwl:hasBroadSynonym "zygote" ; oboInOwl:hasDbXref "BTO:0000854", "EHDAA2:0004546", "FMA:72395" ; a owl:Class ; rdfs:label "animal zygote" ; rdfs:subClassOf obo:CL_0000007, obo:CL_0000255, obo:CL_0010017, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_33208 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0010017 [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_33208 ] ) ] ; skos:prefLabel "animal zygote" . obo:CL_0000366 obo:IAO_0000115 "Obsolete. Use PO:0000084 from Plant Ontology instead. Male gamete, part of male germ unit." ; obo:IAO_0100001 obo:PO_0000084 ; oboInOwl:hasRelatedSynonym "gametophyte sperm cell", "male gametophyte sperm cell", "pollen germ cell" ; a owl:Class ; rdfs:label "obsolete sperm cell (sensu Viridiplantae)" ; owl:deprecated true . obo:CL_0000367 oboInOwl:hasRelatedSynonym "glial cell (sensu Nematoda)" ; a owl:Class ; rdfs:label "sheath cell (sensu Nematoda)" ; rdfs:subClassOf obo:CL_0000619 . obo:CL_0000368 obo:IAO_0000115 "Obsolete. Use PO:0000352 from Plant Ontology instead. Cell containing glucosinolates ('mustard oil glucosides') and myrosinases, enzymes hydrolyzing the glucosinolates. Occurs in eleven dicotyledon families, the two largest of which are the Brassicaceae and Euphorbiaceae." ; obo:IAO_0100001 obo:PO_0000352 ; a owl:Class ; rdfs:label "obsolete myrosin cell" ; owl:deprecated true . obo:CL_0000369 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002372 ; a owl:Class ; owl:deprecated true . obo:CL_0000370 obo:IAO_0000115 "Obsolete. Use PO:0000078 from Plant Ontology instead. Parenchyma cell with the wall ingrowth (or invaginations) that increase the surface of the plasmalemma. Appears to be specialized for short-distance transfer of solutes." ; obo:IAO_0100001 obo:PO_0000078 ; oboInOwl:hasRelatedSynonym "intermediary cell" ; a owl:Class ; rdfs:label "obsolete transfer cell" ; owl:deprecated true . obo:CL_0000371 obo:IAO_0000115 "The cell protoplasm after removal of the cell wall." ; obo:RO_0002161 obo:NCBITaxon_33208 ; oboInOwl:hasDbXref "MESH:D011523" ; a owl:Class ; rdfs:label "protoplast" ; rdfs:subClassOf obo:CL_0000578 . obo:CL_0000372 obo:IAO_0000115 "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization that forms a socket around the base of a cuticular specialization produced by a trichogen cell." ; oboInOwl:hasBroadSynonym "socket cell" ; oboInOwl:hasDbXref "FBbt:00005171" ; a owl:Class ; rdfs:label "tormogen cell" ; rdfs:subClassOf obo:CL_0000463 . obo:CL_0000373 obo:IAO_0000115 "A progenitor cell found in the larval epidermis of insects and that gives rise to the adult abdominal epidermis." ; oboInOwl:hasDbXref "FBbt:00001789" ; a owl:Class ; rdfs:label "histoblast" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_50557 ] . obo:CL_0000374 obo:IAO_0000115 "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization, often in the form of a hair, bristle, peg or scale. The base of this specialization is often surrounded by a socket produced by a closely associated tormogen cell." ; oboInOwl:hasBroadSynonym "hair cell" ; oboInOwl:hasDbXref "BTO:0004744", "FBbt:00005169" ; a owl:Class ; rdfs:label "trichogen cell" ; rdfs:subClassOf obo:CL_0000463 . obo:CL_0000375 obo:IAO_0100001 obo:CL_0007010 ; oboInOwl:hasDbXref "BTO:0002051" ; a owl:Class ; rdfs:label "obsolete osteoprogenitor cell" ; owl:deprecated true . obo:CL_0000376 a owl:Class ; rdfs:label "humidity receptor cell" ; rdfs:subClassOf obo:CL_0000006 . obo:CL_0000377 a owl:Class ; rdfs:label "tracheoblast" ; rdfs:subClassOf obo:CL_0000069 . obo:CL_0000378 oboInOwl:hasExactSynonym "support cell (sensu Nematoda and Protostomia)" ; a owl:Class ; rdfs:label "supporting cell (sensu Nematoda and Protostomia)" ; rdfs:subClassOf obo:CL_0000630 . obo:CL_0000379 oboInOwl:hasDbXref "ZFA:0009185" ; a owl:Class ; rdfs:label "sensory processing neuron" ; rdfs:subClassOf obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050893 ] . obo:CL_0000380 obo:IAO_0000115 "The support cell that makes the thecogen dendritic cap - a cuticle-like matrix around the tip of the eo-dendrite and which encloses the soma of the eo-neuron." ; oboInOwl:hasDbXref "FBbt:00005173" ; oboInOwl:hasExactSynonym "fly sheath cell" ; a owl:Class ; rdfs:label "thecogen cell" ; rdfs:subClassOf obo:CL_0000378 . obo:CL_0000381 obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000165 ; a owl:Class ; rdfs:comment "'neuroendocrine cell' (which has exact synonym \"neurosecretory cell\") and 'neurosecretory neuron' may all refer to the same cell type." ; rdfs:label "obsolete neurosecretory neuron" ; owl:deprecated true . obo:CL_0000382 obo:IAO_0000115 "A cell that is part of a scolopidium and surrounds the dendrite of a scolopidial neuron." ; oboInOwl:hasDbXref "FBbt:00005219" ; oboInOwl:hasExactSynonym "scolopidial sheath cell" ; a owl:Class ; rdfs:label "scolopale cell" ; rdfs:subClassOf obo:CL_0000255, obo:CL_0000378, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001038 ] . obo:CL_0000383 oboInOwl:hasDbXref "ZFA:0009187" ; a owl:Class ; rdfs:label "nephrogenic mesenchyme stem cell" ; rdfs:subClassOf obo:CL_0000134, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000134 ] . obo:CL_0000384 oboInOwl:hasDbXref "ZFA:0009188" ; a owl:Class ; rdfs:label "ligament cell" ; rdfs:subClassOf obo:CL_0000630 . obo:CL_0000385 obo:IAO_0000115 "A precursor of mature hemocytes." ; obo:RO_0002161 obo:NCBITaxon_33511 ; oboInOwl:hasDbXref "FBbt:00005062" ; a owl:Class ; rdfs:label "prohemocyte (sensu Nematoda and Protostomia)" ; rdfs:subClassOf obo:CL_0008001 . obo:CL_0000386 obo:IAO_0000233 ; a owl:Class ; rdfs:comment "The obsoleted term is redundant" ; rdfs:label "obsolete attachment cell" ; owl:deprecated true . obo:CL_0000387 obo:IAO_0000115 "A blood cell of the circulatory system of arthropods." ; oboInOwl:hasDbXref "FBbt:00005063" ; a owl:Class ; rdfs:label "hemocyte (sensu Arthropoda)" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000255, obo:CL_0000390, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_6656 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000385 ] . obo:CL_0000388 obo:IAO_0000115 "An elongated fibrocyte that is part of a tendon. The cytoplasm is stretched between the collagen fibres of the tendon. They have a central cell nucleus with a prominent nucleolus. Tendon cells have a well-developed rough endoplasmic reticulum and they are responsible for synthesis and turnover of tendon fibres and ground substance." ; oboInOwl:hasDbXref "ZFA:0009189" ; oboInOwl:hasExactSynonym "muscle attachment cell" ; oboInOwl:hasRelatedSynonym "tenocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "tendon cell" ; rdfs:subClassOf obo:CL_0000135, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000043 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000043 ] ) ] . obo:CL_0000389 a owl:Class ; rdfs:label "socket cell (sensu Nematoda)" ; rdfs:subClassOf obo:CL_0000619, obo:CL_0000658 . obo:CL_0000390 obo:RO_0002161 obo:NCBITaxon_33511 ; a owl:Class ; rdfs:label "blood cell (sensu Nematoda and Protostomia)" ; rdfs:subClassOf obo:CL_0000081 . obo:CL_0000391 obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000394 ; a owl:Class ; rdfs:comment "Obsoleted as podocytes are not a distinct cell type from plasmatocytes." ; rdfs:label "obsolete podocyte (sensu Diptera)" ; owl:deprecated true . obo:CL_0000392 obo:IAO_0000115 "A hemocyte that synthesizes and secretes melanins as part of the antimicrobial immune response. It is characterized morphologically by crystal inclusions of phenoloxidases in its cytoplasm, hence its name." ; a owl:Class ; rdfs:label "crystal cell" ; rdfs:subClassOf obo:CL_0000387, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000395 ] . obo:CL_0000393 obo:IAO_0000115 "A cell whose function is determined by its response to an electric signal." ; oboInOwl:hasDbXref "ZFA:0009190" ; a owl:Class ; rdfs:label "electrically responsive cell" ; rdfs:subClassOf obo:CL_0000211 ; skos:prefLabel "electrically responsive cell" . obo:CL_0000394 obo:IAO_0000115 "A phagocytic hemocyte, responsible for the engulfment of small particles, microbes, and apoptotic tissue debris. It may also secretes antimicrobial peptides and contribute to the production and secretion of proteins of the hemolymph." ; oboInOwl:hasDbXref "FBbt:00001685" ; oboInOwl:hasRelatedSynonym "macrophage" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "plasmatocyte" ; rdfs:subClassOf obo:CL_0000387, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035010 ] . obo:CL_0000395 obo:IAO_0000115 "A precursor of mature crystal cells." ; oboInOwl:hasDbXref "FBbt:00001689" ; a owl:Class ; rdfs:label "procrystal cell" ; rdfs:subClassOf obo:CL_0000385 . obo:CL_0000396 obo:IAO_0000115 "A hemocyte found in immuno-stimulated larvae." ; oboInOwl:hasDbXref "FBbt:00001687" ; a owl:Class ; rdfs:label "lamellocyte" ; rdfs:subClassOf obo:CL_0000387 . obo:CL_0000397 obo:IAO_0000115 "Any interneuron that has its soma located in some ganglion." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "ganglion interneuron" ; rdfs:subClassOf obo:CL_0000099, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000045 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000045 ] ) ] . obo:CL_0000398 obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000385 ; a owl:Class ; rdfs:comment "Obsoleted as this is actually the same thing as prohemocytes." ; rdfs:label "obsolete polygonal cell" ; owl:deprecated true . obo:CL_0000399 obo:IAO_0000115 "Obsolete. Consult Plant Ontology instead. OBSOLETED, not defined prior to obsoletion." ; a owl:Class ; rdfs:label "obsolete phloem element" ; owl:deprecated true . obo:CL_0000400 obo:IAO_0000115 "Obsolete. Use PO:0000332 from Plant Ontology instead. An epidermal cell with a characteristic convoluted anticlinal cell wall that gives a jigsaw like appearance to the lamina." ; obo:IAO_0100001 obo:PO_0000332 ; a owl:Class ; rdfs:label "obsolete pavement cell" ; owl:deprecated true . obo:CL_0000401 obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000394 ; a owl:Class ; rdfs:comment "Obsoleted as plasmatocytes are the macrophages (phagocytic cells) of Diptera." ; rdfs:label "obsolete macrophage (sensu Diptera)" ; owl:deprecated true . obo:CL_0000402 obo:IAO_0000115 "OBSOLETE. An interneuron that has its cell body in a central nervous system." ; obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000099 ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Interneurons are commonly described as being only found in the central nervous system. However, in CL we define 'interneuron' more broadly as any neuron that is neither a motor neuron nor a sensory neuron, regardless of its location, so we need this term to refer strictly to interneurons of the central nervous system." ; rdfs:label "obsolete CNS interneuron" ; owl:deprecated true . obo:CL_0000403 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000850 ; a owl:Class ; owl:deprecated true . obo:CL_0000404 obo:IAO_0000115 "A cell that initiates an electrical signal and passes that signal to another cell." ; oboInOwl:hasDbXref "ZFA:0009193" ; a owl:Class ; rdfs:label "electrically signaling cell" ; rdfs:subClassOf obo:CL_0000211 ; skos:prefLabel "electrically signaling cell" . obo:CL_0000405 obo:IAO_0000233 ; a owl:Class ; rdfs:comment "Obsoleted as the term seems completely unused in the literature." ; rdfs:label "obsolete neuroepidermoblast" ; owl:deprecated true . obo:CL_0000406 oboInOwl:hasDbXref "ZFA:0009194" ; a owl:Class ; rdfs:label "CNS short range interneuron" ; rdfs:subClassOf obo:CL_0000099 . obo:CL_0000407 obo:IAO_0000115 "A cell that anchors the cell body of a scolopidial neuron to the integument." ; oboInOwl:hasDbXref "FBbt:00005221" ; a owl:Class ; rdfs:label "scolopidial ligament cell" ; rdfs:subClassOf obo:CL_0000255, obo:CL_0000378, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001038 ] . obo:CL_0000408 obo:IAO_0000115 "Any male germ cell that has characteristic some haploid and is capable of some fertilization." ; terms:description """The male gamete, also known as a sperm cell, is a highly specialized cell type critical to sexual reproduction. Sperm are produced during a process called spermatogenesis within the male reproductive organ, specifically the testes. They are haploid cells, carrying the genetic material from the male parent, and fuse with the ovum, the female gamete, to form a diploid zygote during fertilization, thereby initiating gestation and the development of a new organism. The male gamete is distinguished by its morphology, notably its elongated shape which is geared towards locomotion. One of the primary characteristics of a male gamete is its flagellum, or tail, which propels the cell towards the female gamete. It additionally contains an elongated head region housing the nucleus, where the genetic material is stored. The anterior section of the head, the acrosome, releases enzymes essential for penetrating the protective layers of the ovum during the fertilization process. The function of male gametes does not cease upon fertilization. In addition to delivering the paternal set of chromosomes, fusion of the sperm cell with the ovum causes an increase in cytosolic Ca2+ which then activates the female egg cell to undergo the so-called cortical reaction during which the egg’s zona pellucida is changed so fusion with additional sperm is prevented. The Ca2+ signal also initiates the development of the zygote and eventual formation of an embryo. Male gametes also contribute towards forming the placenta, which supplies nutrients and removes waste products during gestation. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:0001277", "CALOHA:TS-0949" ; a owl:Class ; rdfs:label "male gamete" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000408" ; rdfs:subClassOf obo:CL_0000015, obo:CL_0000300 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000015 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001375 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0009566 ] ) ] . obo:CL_0000409 obo:IAO_0100001 obo:CL_0000382 ; a owl:Class ; rdfs:comment "Obsoleted as this refers to the same cell type as 'scolopale cell'." ; rdfs:label "obsolete scolopidial sheath cell" ; owl:deprecated true . obo:CL_0000410 oboInOwl:hasDbXref "ZFA:0009195" ; a owl:Class ; rdfs:label "CNS long range interneuron" ; rdfs:subClassOf obo:CL_0000099 . obo:CL_0000411 obo:IAO_0000115 "An epithelial cell of the hypodermis of Caenorhabditis." ; oboInOwl:hasBroadSynonym "roundworm hypodermal cell" ; oboInOwl:hasDbXref "WBbt:0007846", "ZFA:0009196" ; a owl:Class ; rdfs:comment "This term was originally added to CL for parity with the Worm anatomy ontology, which is dedicated to C elegans. It is not clear if it makes sense to try and generalize the concept and include in CL, and this term may be obsoleted in future. Note there is no similarity to the hypodermis in vertebrates." ; rdfs:label "Caenorhabditis hypodermal cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0000228, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_6237 ] . obo:CL_0000412 obo:IAO_0000115 "A cell that contains more than two haploid sets of chromosomes." ; a owl:Class ; rdfs:label "polyploid cell" ; rdfs:subClassOf obo:CL_0000000, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001377 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001377 ] ) ] . obo:CL_0000413 obo:IAO_0000115 "A cell whose nucleus contains a single haploid genome." ; a owl:Class ; rdfs:label "haploid cell" ; rdfs:subClassOf obo:CL_0000000, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001375 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001375 ] ) ] . obo:CL_0000414 obo:IAO_0000115 "OBSOLETE: A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei." ; oboInOwl:consider "CL:0000000", "CL:0000003", "CL:0000255", "CL:0001034" ; a owl:Class ; rdfs:comment "This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell with chromosomes can be classified by its ploidy. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), eukaryotic cell (CL:0000255) or cell in vitro (CL:0001034) as appropriate." ; rdfs:label "obsolete cell by ploidy" ; owl:deprecated true . obo:CL_0000415 obo:IAO_0000115 "A cell whose nucleus has two haploid genomes." ; oboInOwl:hasDbXref "FMA:72300" ; a owl:Class ; rdfs:label "diploid cell" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0000416 a owl:Class ; rdfs:label "polytene cell" ; rdfs:subClassOf obo:CL_0000412 . obo:CL_0000417 a owl:Class ; rdfs:label "endopolyploid cell" ; rdfs:subClassOf obo:CL_0000412 . obo:CL_0000418 obo:IAO_0000115 "An epithelial cell found in C. elegans that firmly hold the outer body wall and the lips to the inner cylinder of the pharynx in a manner that keeps these organs from breaking apart, while still giving each organ freedom of movement during feeding." ; oboInOwl:hasDbXref "WBbt:0005793" ; a owl:Class ; rdfs:label "arcade cell" ; rdfs:subClassOf obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_6237 ] . obo:CL_0000419 obo:IAO_0000115 "An epithelial fate stem cell found in flatworms." ; oboInOwl:hasDbXref "BTO:0003039" ; a owl:Class ; rdfs:label "seam cell" ; rdfs:subClassOf obo:CL_0000036 . obo:CL_0000420 obo:IAO_0000115 "An epithelial cell that forms a syncytium, which is a multinucleated cell resulting from the fusion of multiple cells." ; oboInOwl:hasDbXref "Wikipedia:Syncytium" ; a owl:Class ; rdfs:label "syncytial epithelial cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_4052002 . obo:CL_0000421 obo:IAO_0000115 "A free floating cell, including amebocytes and eleocytes, in the coelom of certain animals, especially annelids." ; oboInOwl:hasDbXref "BTO:0002856", "WBbt:0005751" ; a owl:Class ; rdfs:label "coelomocyte" ; rdfs:subClassOf obo:CL_0000080, obo:CL_0000519 . obo:CL_0000422 obo:IAO_0000115 "A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment." ; a owl:Class ; rdfs:label "mitogenic signaling cell" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0000423 a owl:Class ; rdfs:label "tip cell" ; rdfs:subClassOf obo:CL_0000422 . obo:CL_0000424 obo:IAO_0000115 "A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids." ; oboInOwl:hasDbXref "WBbt:0005812" ; a owl:Class ; rdfs:label "excretory cell" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0000425 obo:IAO_0000115 "Forms the terminal part of the cuticle-lined excretory duct of C. elegans." ; a owl:Class ; rdfs:label "pore cell" ; rdfs:subClassOf obo:CL_0000658 . obo:CL_0000426 obo:IAO_0000233 ; a owl:Class ; rdfs:comment "This is a cell used in tissue engineering and is out of scope for CL." ; rdfs:label "obsolete scaffold cell" ; owl:deprecated true . obo:CL_0000427 obo:IAO_0000115 "A scaffolding cell type found in C. elegans, this cell plays a supportive role to the muscle arms. May also have an endocrine role." ; a owl:Class ; rdfs:label "GLR cell" ; rdfs:subClassOf obo:CL_0002320 . obo:CL_0000428 oboInOwl:hasDbXref "ZFA:0000084" ; a owl:Class ; rdfs:label "yolk cell" ; rdfs:subClassOf obo:CL_0000325, obo:CL_0000349 . obo:CL_0000429 obo:IAO_0000115 "A columnar epithelial cell that is part of an insect imaginal disc." ; oboInOwl:hasDbXref "FBbt:00007108" ; a owl:Class ; rdfs:comment "This term does not encompass all the cell types that may be found in an epithelial disc (such as the peripodial or adepithelial cells), only the cells that form the disc epithelium proper." ; rdfs:label "imaginal disc cell" ; rdfs:subClassOf obo:CL_0000146, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000939 ] . obo:CL_0000430 obo:IAO_0000115 "A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red." ; oboInOwl:hasDbXref "ZFA:0009198" ; oboInOwl:hasRelatedSynonym "xanthophore" ; a owl:Class ; rdfs:label "xanthophore cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000147, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0005002 ] . obo:CL_0000431 obo:IAO_0000115 "A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platelets or iridisomes. The color-generating components produce a silver, gold, or iridescent color." ; oboInOwl:hasDbXref "ZFA:0009199" ; oboInOwl:hasRelatedSynonym "guanophore" ; a owl:Class ; rdfs:label "iridophore" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000147, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0005001 ] . obo:CL_0000432 obo:IAO_0000115 "A fibroblast that synthesizes collagen and uses it to produce reticular fibers, thus providing structural support. Reticular cells are found in many organs, including the spleen, lymph nodes and kidneys. Subtypes of reticular cells include epithelial, mesenchymal, and fibroblastic reticular cells. Fibroblastic reticular cells are involved in directing B cells and T cells to specific regions within a tissue, whereas epithelial and mesenchymal reticular cells are associated with certain areas of the brain." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:62877", "ZFA:0009200" ; oboInOwl:hasExactSynonym "reticulum cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "reticular cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" ; rdfs:subClassOf obo:CL_0000057 . obo:CL_0000433 obo:IAO_0000115 "Obsolete. Use PO:0000244 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that will undergo megagametogenesis." ; obo:IAO_0100001 obo:PO_0000244 ; a owl:Class ; rdfs:label "obsolete functional megaspore" ; owl:deprecated true . obo:CL_0000434 obo:IAO_0000115 "A secretory cell that discharges its product without loss of cytoplasm." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "eccrine cell" ; rdfs:subClassOf obo:CL_1100001 . obo:CL_0000435 oboInOwl:hasDbXref "ZFA:0009201" ; a owl:Class ; rdfs:label "alkali secreting cell" ; rdfs:subClassOf obo:CL_0000151 . obo:CL_0000436 a owl:Class ; rdfs:label "vaginal lubricant secreting cell" ; rdfs:subClassOf obo:CL_0000151, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] . obo:CL_0000437 obo:IAO_0000115 "A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH)." ; oboInOwl:hasDbXref "BTO:0002482", "FMA:83100", "ZFA:0009202" ; oboInOwl:hasExactSynonym "delta basophil", "follicle stimulating hormone secreting cell", "gonadotrope", "gonadotrope cell", "gonadotroph", "gonadotropic cell", "pituitary delta cell" ; a owl:Class ; rdfs:label "gonadtroph" ; rdfs:subClassOf obo:CL_0000438, obo:CL_0000639 . obo:CL_0000438 obo:IAO_0000115 "A peptide hormone secreting cell pituitary that produces luteinizing hormone." ; oboInOwl:hasDbXref "ZFA:0009203" ; a owl:Class ; rdfs:label "luteinizing hormone secreting cell" ; rdfs:subClassOf obo:CL_0000151, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032275 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032275 ] ) ] ; skos:prefLabel "luteinizing hormone secreting cell" . obo:CL_0000439 obo:IAO_0000115 "A peptide hormone cell that secretes prolactin." ; oboInOwl:hasDbXref "ZFA:0009204" ; a owl:Class ; rdfs:label "prolactin secreting cell" ; rdfs:subClassOf obo:CL_0000154, obo:CL_0000167, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070459 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070459 ] ) ] ; skos:prefLabel "prolactin secreting cell" . obo:CL_0000440 obo:IAO_0000115 "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." ; oboInOwl:hasDbXref "BTO:0002277", "ZFA:0009205" ; oboInOwl:hasExactSynonym "melanotrope", "melanotroph" ; a owl:Class ; rdfs:label "melanocyte stimulating hormone secreting cell" ; rdfs:subClassOf obo:CL_0000167, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0036160 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0036160 ] ) ] ; skos:prefLabel "melanocyte stimulating hormone secreting cell" . obo:CL_0000441 obo:IAO_0000115 "A stem cell that gives rise to the follicle cells that surround the oocyte in female arthropods." ; oboInOwl:hasBroadSynonym "somatic stem cell" ; oboInOwl:hasDbXref "FBbt:00004903" ; a owl:Class ; rdfs:label "follicle stem cell (sensu Arthropoda)" ; rdfs:subClassOf obo:CL_0000036, _:genid1645 . obo:CL_0000442 obo:IAO_0000115 "A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0004267", "FMA:83037", "MESH:D020566" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Due to its unique lineage and distinct function, this is not a type of dendritic cell; CL:0000451." ; rdfs:label "follicular dendritic cell" ; rdfs:subClassOf obo:CL_0000451 ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-red-pulp/v1.2/assets/2d-ftu-spleen-red-pulp.png", "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-white-pulp/v1.2/assets/2d-ftu-spleen-white-pulp.png" . obo:CL_0000443 obo:IAO_0000115 "Any secretory cell that is capable of some calcitonin secretion." ; oboInOwl:hasDbXref "ZFA:0009206" ; a owl:Class ; rdfs:label "calcitonin secreting cell" ; rdfs:subClassOf obo:CL_0000167, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0036161 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0036161 ] ) ] . obo:CL_0000444 obo:IAO_0000115 "A muscle cell in which the fibers are organised into sarcomeres but in which adjacent myofibrils are offset from each other, producing an oblique banding pattern." ; a owl:Class ; rdfs:comment "Examples include the somatic muscles of nemotodes and cephalopods." ; rdfs:label "obliquely striated muscle cell" ; rdfs:subClassOf obo:CL_0000737, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002479 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002479 ] ) ] . obo:CL_0000445 a owl:Class ; rdfs:label "apoptosis fated cell" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0000446 obo:IAO_0000115 "An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone." ; oboInOwl:hasDbXref "BTO:0004712", "CALOHA:TS-2140", "FMA:69078" ; oboInOwl:hasExactSynonym "parathyroid chief cell", "parathyroid gland chief cell", "parathyroid hormone secreting cell", "principal cell of parathyroid gland" ; a owl:Class ; rdfs:label "chief cell of parathyroid gland" ; rdfs:subClassOf obo:CL_1001593, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011197 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035898 ] . obo:CL_0000447 a owl:Class ; rdfs:label "carbohydrate secreting cell" ; rdfs:subClassOf obo:CL_0000151 ; skos:prefLabel "carbohydrate secreting cell" . obo:CL_0000448 obo:IAO_0000115 "An adipocyte with light coloration and few mitochondria. It contains a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole." ; oboInOwl:hasDbXref "CALOHA:TS-1119", "FMA:83434" ; oboInOwl:hasExactSynonym "white adipose cell" ; oboInOwl:hasRelatedSynonym "white fat cell" ; a owl:Class ; rdfs:label "white adipocyte" ; rdfs:subClassOf obo:CL_0000136, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001347 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002334 ] . obo:CL_0000449 obo:IAO_0000115 "A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." ; oboInOwl:hasDbXref "CALOHA:TS-0099", "FMA:83435" ; oboInOwl:hasExactSynonym "brown adipose cell", "brown fat cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "brown adipocyte" ; rdfs:subClassOf obo:CL_0000136, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001348 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002335 ] . obo:CL_0000450 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000136 ; a owl:Class ; owl:deprecated true . obo:CL_0000451 obo:IAO_0000115 "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0002042", "CALOHA:TS-0194", "FMA:83036", "MESH:D003713", "ZFA:0009209" ; oboInOwl:hasRelatedSynonym "interdigitating cell", "veiled cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "dendritic cell" ; rdfs:subClassOf obo:CL_0000113, obo:CL_0000145, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042613 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045580 ] ; owl:disjointWith obo:CL_0000542 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000738 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002504 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0019882 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045580 ] ) ] . obo:CL_0000452 obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0002258 ; a owl:Class ; rdfs:comment "This term is redundant and has been merged with thyroid follicular cell" ; rdfs:label "obsolete thyroid hormone secreting cell" ; owl:deprecated true . obo:CL_0000453 obo:IAO_0000115 "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000705", "CALOHA:TS-2375", "FMA:63072", "MESH:D007801" ; oboInOwl:hasExactSynonym "LC" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis." ; rdfs:label "Langerhans cell" ; rdfs:subClassOf obo:CL_0000766, obo:CL_0000990, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001293 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000763 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002828 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001293 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002828 ] ) ] . obo:CL_0000454 obo:IAO_0000115 "A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types." ; oboInOwl:hasDbXref "ZFA:0009211" ; oboInOwl:hasExactSynonym "adrenaline secreting cell", "epinephrin secreting cell" ; a owl:Class ; rdfs:label "epinephrine secreting cell" ; rdfs:subClassOf obo:CL_0000457, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048242 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048242 ] ) ] . obo:CL_0000455 obo:IAO_0000115 "Obsolete. Use PO:0004531 from Plant Ontology instead. A cell characterized by conspicuous and rather stable accumulation of starch." ; obo:IAO_0100001 obo:PO_0004531 ; a owl:Class ; rdfs:label "obsolete starch sheath cell" ; owl:deprecated true . obo:CL_0000456 obo:IAO_0000115 "Any secretory cell that is capable of some mineralocorticoid secretion." ; a owl:Class ; rdfs:label "mineralocorticoid secreting cell" ; rdfs:subClassOf obo:CL_0000174, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035931 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035931 ] ) ] . obo:CL_0000457 oboInOwl:hasDbXref "ZFA:0009212" ; a owl:Class ; rdfs:label "biogenic amine secreting cell" ; rdfs:subClassOf obo:CL_0000151 ; skos:prefLabel "biogenic amine secreting cell" . obo:CL_0000458 obo:IAO_0000115 "A cell type that secretes 5-Hydroxytryptamine (serotonin)." ; oboInOwl:hasDbXref "ZFA:0009213" ; oboInOwl:hasExactSynonym "5-HT secreting cell", "5-Hydroxytryptamine secreting cell" ; a owl:Class ; rdfs:label "serotonin secreting cell" ; rdfs:subClassOf obo:CL_0000457, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001820 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001820 ] ) ] . obo:CL_0000459 obo:IAO_0000115 "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." ; oboInOwl:hasDbXref "ZFA:0009214" ; oboInOwl:hasExactSynonym "noradrenaline secreting cell", "norepinephrin secreting cell", "norepinephrine secreting cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "noradrenergic cell" ; rdfs:subClassOf obo:CL_0000457, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048243 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048243 ] ) ] ; skos:prefLabel "noradrenergic cell" . obo:CL_0000460 obo:IAO_0000115 "Any secretory cell that is capable of some glucocorticoid secretion." ; oboInOwl:hasDbXref "ZFA:0009215" ; a owl:Class ; rdfs:label "glucocorticoid secreting cell" ; rdfs:subClassOf obo:CL_0000174, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035933 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035933 ] ) ] . obo:CL_0000461 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000648 ; a owl:Class ; owl:deprecated true . obo:CL_0000462 obo:IAO_0000115 "A cell of mesodermal origin that is closely associated with the epithelium of an imaginal disc. It is a precursor of some of the insect's adult muscles." ; oboInOwl:hasDbXref "FBbt:00003219" ; a owl:Class ; rdfs:label "adepithelial cell" ; rdfs:subClassOf obo:CL_0000680, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_50557 ] . obo:CL_0000463 obo:IAO_0000115 "An epidermal cell that secretes chitinous cuticle from its apical side." ; oboInOwl:hasDbXref "FBbt:00007325" ; a owl:Class ; rdfs:comment "While insect epidermis is generally columnar/cuboidal, there are certainly well studied cases where it is not (e.g.- Rhodnius prolixus when starved). So it would be safer to add this as a differentium for particular species where this is known. -DSJ." ; rdfs:label "epidermal cell (sensu Arthropoda)" ; rdfs:subClassOf obo:CL_0000362, obo:CL_0000710, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_6656 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000464 ] . obo:CL_0000464 obo:IAO_0000115 "An epidermal progenitor cell that arises from neuroectoderm and in turn gives rise to the epidermal sheath of ventral and cephalic regions." ; oboInOwl:hasDbXref "FBbt:00004994" ; a owl:Class ; rdfs:label "epidermoblast" ; rdfs:subClassOf obo:CL_0000710, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000114 ] . obo:CL_0000465 obo:IAO_0000115 "A precursor of the cells that form the dorsal vessel of arthropods." ; oboInOwl:hasDbXref "FBbt:00001666" ; a owl:Class ; rdfs:label "cardioblast (sensu Arthropoda)" ; rdfs:subClassOf obo:CL_0010021, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_6656 ] . obo:CL_0000466 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000193 ; a owl:Class ; owl:deprecated true . obo:CL_0000467 obo:IAO_0000115 "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." ; oboInOwl:hasDbXref "ZFA:0009216" ; oboInOwl:hasExactSynonym "ACTH secreting cell", "adrenocorticotrophic hormone secreting cell", "corticotrophin hormone secreting cell", "corticotropin hormone secreting cell", "corticotropin secreting cell" ; a owl:Class ; rdfs:label "adrenocorticotropic hormone secreting cell" ; rdfs:subClassOf obo:CL_0000167, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0051458 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0051458 ] ) ] ; skos:prefLabel "adrenocorticotropic hormone secreting cell" . obo:CL_0000468 obo:IAO_0000115 "A precursor of the central nervous system that gives rise to both neurons and glial cells." ; oboInOwl:hasDbXref "FBbt:00005147" ; oboInOwl:hasExactSynonym "neuro-glioblast", "neuroglioblast" ; a owl:Class ; rdfs:label "neuroglioblast (sensu Nematoda and Protostomia)" ; rdfs:subClassOf obo:CL_0000047, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_33317 ] . obo:CL_0000469 obo:IAO_0000115 "A neural progenitor cell that is the daughter of a neuroblast (sensu arthopoda). The progeny of ganglion mother cells develop into neurons, glia and (occasionally) epithelial cells." ; oboInOwl:hasDbXref "FBbt:00005149" ; a owl:Class ; rdfs:label "ganglion mother cell" ; rdfs:subClassOf obo:CL_0011020, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000338 ] . obo:CL_0000470 oboInOwl:hasDbXref "ZFA:0009217" ; a owl:Class ; rdfs:label "digestive enzyme secreting cell" ; rdfs:subClassOf obo:CL_0000154 . obo:CL_0000471 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000295 ; a owl:Class ; owl:deprecated true . obo:CL_0000472 obo:IAO_0000115 "Obsolete. Use PO:0000076 from Plant Ontology instead. OBSOLETE, use term from Plant Ontology. Parenchyma cells containing chloroplasts; a component of leaf mesophyll and other green parenchyma tissue." ; obo:IAO_0100001 obo:PO_0000076 ; a owl:Class ; rdfs:label "obsolete chlorenchyma cell" ; owl:deprecated true . obo:CL_0000473 obo:IAO_0000115 "OBSOLETE: A cell whose primary function is to protect the organism." ; obo:IAO_0000233 ; a owl:Class ; rdfs:comment "Unsustainable functional grouping term of dubious utility." ; rdfs:label "OBSOLETE defensive cell" ; owl:deprecated true . obo:CL_0000474 obo:IAO_0000115 "An insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel." ; oboInOwl:hasDbXref "FBbt:00005058" ; oboInOwl:hasNarrowSynonym "pericardial cell" ; a owl:Class ; rdfs:label "pericardial nephrocyte" ; rdfs:subClassOf obo:CL_0000519, obo:CL_0002520 . obo:CL_0000475 obo:IAO_0000115 "Obsolete. Use PO:0000245 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that do not participate in megagametogenesis." ; obo:IAO_0100001 obo:PO_0000245 ; a owl:Class ; rdfs:label "obsolete degenerate megaspore" ; owl:deprecated true . obo:CL_0000476 obo:IAO_0000115 "A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center." ; oboInOwl:hasDbXref "FMA:83099", "MESH:D052684", "ZFA:0009218" ; oboInOwl:hasExactSynonym "beta-basophil", "thyroid stimulating hormone secreting cell", "thyrotrope" ; a owl:Class ; rdfs:label "thyrotroph" ; rdfs:subClassOf obo:CL_0000639, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070460 ] . obo:CL_0000477 obo:IAO_0000115 "A somatic epithelial cell of the insect egg chamber." ; oboInOwl:hasBroadSynonym "follicle cell", "ovarian follicle cell" ; oboInOwl:hasDbXref "FBbt:00004904" ; a owl:Class ; rdfs:label "follicle cell of egg chamber" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000500, _:genid1778, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000441 ] . obo:CL_0000478 obo:IAO_0000115 "A peptide hormone secreting cell that secretes oxytocin stimulating hormone" ; a owl:Class ; rdfs:label "oxytocin stimulating hormone secreting cell" ; rdfs:subClassOf obo:CL_0000167 . obo:CL_0000479 obo:IAO_0000115 "A peptide hormone secreting cell that secretes vasopressin stimulating hormone" ; a owl:Class ; rdfs:label "vasopressin stimulating hormone secreting cell" ; rdfs:subClassOf obo:CL_0000167 . obo:CL_0000480 obo:IAO_0000115 "A peptide hormone secreting cell that secretes secretin stimulating hormone" ; a owl:Class ; rdfs:label "secretin stimulating hormone secreting cell" ; rdfs:subClassOf obo:CL_0000167 . obo:CL_0000481 obo:IAO_0000115 "A peptide hormone secreting cell that secretes cholecystokin stimulating hormone." ; a owl:Class ; rdfs:label "cholecystokin stimulating hormone secreting cell" ; rdfs:subClassOf obo:CL_0000167 . obo:CL_0000482 obo:IAO_0000115 "An endocrine cell that secretes juvenile hormone." ; oboInOwl:hasDbXref "FBbt:00058020" ; a owl:Class ; rdfs:label "juvenile hormone secreting cell" ; rdfs:subClassOf obo:CL_0000151, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045443 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045443 ] ) ] . obo:CL_0000483 obo:IAO_0000115 "A peptide hormone secreting cell that secretes bombesin stimulating hormone." ; a owl:Class ; rdfs:label "bombesin stimulating hormone secreting cell" ; rdfs:subClassOf obo:CL_0000167 . obo:CL_0000484 obo:IAO_0000115 "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "MC(TC)", "MCTC", "TC mast cells" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "They are CD88-positive. The cytoplasmic granules contain high levels of histamine and heparin (mouse) or major neutral proteases, tryptase, chymase, carboxypeptidase A, and cathepsin G (humans). Reportedly, they cannot produce leukotrienes (LTC4) and IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype." ; rdfs:label "connective tissue type mast cell" ; rdfs:subClassOf obo:CL_0000097, obo:CL_0002320 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000097 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002384 ] ) ] . obo:CL_0000485 obo:IAO_0000115 "Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "MC(T)", "MCT", "T mast cells" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "They are CD88-negative. The cytoplasmic granules contain low levels of histamine and high levels of chondroitin sulfate (mouse) or major neutral proteases and tryptase (humans). Additionally, they can produce leukotrienes (LTC4), IL-5, IL-6, and low levels of IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype." ; rdfs:label "mucosal type mast cell" ; rdfs:subClassOf obo:CL_0000097, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001961 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002540 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000097 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001961 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002540 ] ) ] . obo:CL_0000486 obo:IAO_0000115 "A large binucleate cell that forms a 'garland' around the anterior end of the proventriculus (cardia) at its junction with the esophagus in both adults and larvae flies. Each cell is surrounded by a basement membrane and there are numerous micro-invaginations (lacunae) extending from the surface into the cytoplasm. At the mouth of each lacuna is a doubled filament forming a specialised filtration system (diaphragm). The filtrate is endocytosed from the lacunae." ; oboInOwl:hasBroadSynonym "garland nephrocyte" ; oboInOwl:hasDbXref "BTO:0004596", "FBbt:00005059" ; a owl:Class ; rdfs:label "garland cell" ; rdfs:subClassOf obo:CL_0000227, obo:CL_0000519, obo:CL_0002520 . obo:CL_0000487 obo:IAO_0000115 "A secretory cell of ectodermal origin. This cell may have important functions in fatty acid and hydrocarbon metabolism and is metabolically linked to the fat body and tracheae. This cell is exclusive of arthropods." ; oboInOwl:hasDbXref "FBbt:00004995" ; a owl:Class ; rdfs:comment "Oenocytes are highly variable in size, shape, cluster formation and anatomical location. In adults, oenocytes tend to be smaller but more numerous than in larvae. While oenocytes have been found in arachnids and crustaceans, they have been most abundantly described in insects." ; rdfs:label "oenocyte" ; rdfs:subClassOf obo:CL_0000151, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_6656 ] . obo:CL_0000488 obo:IAO_0000115 "A photoreceptor cell that detects visible light." ; oboInOwl:hasDbXref "ZFA:0009219" ; a owl:Class ; rdfs:label "visible light photoreceptor cell" ; rdfs:subClassOf obo:CL_0000210, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0009584 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000210 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0009584 ] ) ] . obo:CL_0000489 a owl:Class ; rdfs:label "scotopic photoreceptor cell" ; rdfs:subClassOf obo:CL_0000210 . obo:CL_0000490 oboInOwl:hasDbXref "ZFA:0009220" ; a owl:Class ; rdfs:label "photopic photoreceptor cell" ; rdfs:subClassOf obo:CL_0000488 . obo:CL_0000491 obo:IAO_0000115 "OBSOLETE: A cell responsible for spontaneous cytotoxicity of a variety of tumor cells without prior immunization. These natural killer cells are found in non-immune humans and experimental animals and are thought by some to be the same as killer cells (killing by antibody-dependent cell cytotoxicity), but they can also kill in the absence of antibody." ; a owl:Class ; rdfs:comment "This term had an incorrect definition and was overly broad. Consider using 'cytotoxic T cell ; CL:0000910' (in most cases) or another lymphocyte cell type if cytotoxicity is shown to be part of the cell's phenotype in a particular experimental situation." ; rdfs:label "obsolete cytotoxic T cell" ; owl:deprecated true . obo:CL_0000492 obo:IAO_0000115 "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "CALOHA:TS-1146", "FMA:70572" ; oboInOwl:hasExactSynonym "CD4-positive T-helper cell", "CD4-positive helper T lymphocyte", "CD4-positive helper T-cell", "CD4-positive helper T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "CD4-positive helper T cell" ; rdfs:subClassOf obo:CL_0000624, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000896 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] ) ] . obo:CL_0000493 obo:IAO_0000115 "OBSOLETE: Subpopulation of CD4+ cells which induce CD8+ suppressor T cells to suppress antibody production by B cells. They also stimulate other cellular immune responses." ; a owl:Class ; rdfs:comment "This term was defined too narrowly; consider using the term 'regulatory T cell ; CL:0000815' instead." ; rdfs:label "obsolete regulatory T cell" ; owl:deprecated true . obo:CL_0000494 obo:IAO_0000115 "A photoreceptor cell that detects ultraviolet light." ; oboInOwl:hasDbXref "ZFA:0009221" ; a owl:Class ; rdfs:label "UV sensitive photoreceptor cell" ; rdfs:subClassOf obo:CL_0000210, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0009589 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000210 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0009589 ] ) ] . obo:CL_0000495 obo:IAO_0000115 "A photoreceptor cell that is sensitive to blue light." ; oboInOwl:hasDbXref "ZFA:0009222" ; a owl:Class ; rdfs:label "blue sensitive photoreceptor cell" ; rdfs:subClassOf obo:CL_0000490 . obo:CL_0000496 obo:IAO_0000115 "A photoreceptor cell that is sensitive to green light." ; oboInOwl:hasDbXref "ZFA:0009223" ; a owl:Class ; rdfs:label "green sensitive photoreceptor cell" ; rdfs:subClassOf obo:CL_0000490 . obo:CL_0000497 obo:IAO_0000115 "A photoreceptor cell that is sensitive to red light." ; oboInOwl:hasDbXref "ZFA:0009224" ; a owl:Class ; rdfs:label "red sensitive photoreceptor cell" ; rdfs:subClassOf obo:CL_0000490 . obo:CL_0000498 obo:IAO_0000115 "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." ; oboInOwl:hasDbXref "FMA:84776", "ZFA:0009225" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "inhibitory interneuron" ; rdfs:subClassOf obo:CL_0000099 ; skos:prefLabel "inhibitory interneuron" . obo:CL_0000499 obo:IAO_0000115 "A connective tissue cell of an organ found in the loose connective tissue." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0002064", "FMA:83624", "ZFA:0009226" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "stromal cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000134 ] ; skos:prefLabel "stromal cell" . obo:CL_0000500 obo:IAO_0000115 "An epithelial somatic cell associated with a maturing oocyte." ; a owl:Class ; rdfs:label "follicular epithelial cell" ; rdfs:subClassOf obo:CL_0000066 . obo:CL_0000501 obo:IAO_0000115 "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." ; terms:description """Granulosa cells are a type of somatic cell most commonly known for their crucial role within the ovarian follicles of female mammalian species. Named for their grainy appearance, they are situated in the follicular epithelium, lining the inner part of the follicle and directly surrounding the oocyte. These cells stand as an integral part of the ovarian structure and function. One of the primary roles of granulosa cells is to aid in the production and secretion of sex hormones, particularly estrogen. They achieve this by working in tandem with theca cells, which stay attached to the external layer of the follicle. Theca cells produce androstenedione (a type of androgen) which granulosa cells then convert into estradiol, a form of estrogen, with the help of the enzyme aromatase. Moreover, granulosa cells participate in luteinization, transforming into luteal granulosa cells as a response to the luteinizing hormone during ovulation. This allows the formation of the corpus luteum, responsible for the secretion of progesterone necessary to maintain pregnancy. Granulosa cells also play a significant role in follicular development and oocyte maturation, involving close communication with the contained oocyte. They support the oocyte through the provision of nutrients and growth factors, control its meiotic cycle and ensure it is appropriately oriented and instructed for impending ovulation. Furthermore, granulosa cells contribute to the formation of the zona pellucida and the follicular fluid, providing an optimal environment for the oocyte's growth and maturation. These cells, thus, perform multiple vital roles, underscoring their importance in fertility and reproductive health. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:0000542", "CALOHA:TS-0729", "FMA:18718", "ZFA:0009227" ; oboInOwl:hasExactSynonym "granulosa cell of ovary" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "granulosa cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000501" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000174, obo:CL_0002174, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_4033066 ] . obo:CL_0000502 obo:IAO_0000115 "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." ; terms:description """Type D enteroendocrine cells, also known as D or delta cells, are specialized hormone-releasing cells found in the pancreas and also scattered throughout the lining of the gastrointestinal tract in mammals, notably within the stomach and the upper part of the small intestine known as the duodenum. The primary role of D cells is to produce and secrete somatostatin, a potent paracrine inhibitor. In the gastrointestinal tract, somatostatin slows down digestion. It reduces gastric acid secretion and slows down the rate of gastric emptying, thereby prolonging and controling the digestive p. Functionally, these effects are aimed at sustaining nutrient absorption to optimize energy extraction from consumed food. In the pancreas, D cells maintain a vital role in endocrine regulation. D cells in the pancreatic islands secrete somatostatin to inhibit the release of both insulin and glucagon from type A cells and B cells, glucoregulatory hormones that control blood sugar levels. Hence, D cells contribute considerably to the homeostasis of the body's metabolic processes. It is also noteworthy that dysfunctional D cells or irregular somatostatin signaling has been associated with certain pathologies such as neuroendocrine tumors and gastric ulcers. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:62935", "ZFA:0009228" ; oboInOwl:hasExactSynonym "D cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type D enteroendocrine cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000502" ; rdfs:subClassOf obo:CL_0000164, obo:CL_0000165, obo:CL_0000172 . obo:CL_0000503 obo:IAO_0000115 "A specialized stromal cell that forms the theca layer outside the basal lamina lining the ovarian follicle, appearing during the secondary follicle stage." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0002850", "ZFA:0009229" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "theca cell" ; rdfs:subClassOf obo:CL_0002132, obo:CL_0002174, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000155 ] . obo:CL_0000504 obo:IAO_0000115 "A enteroendocrine cell part of the glands of the gastric mucosa. They produce histamine and peptides such as chromogranins. This cell type respond to gastrin by releasing histamine which acts as a paracrine stimulator of the release of hydrochloric acid from the gastric parietal cells." ; oboInOwl:hasDbXref "BTO:0002692" ; oboInOwl:hasExactSynonym "ECL" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Consider enterochromaffin cell (CL:0002065). For several years this cell type was \"enterochromaffin cell\" despite a MESH dbxref and a free text definition that clearly meant enterochromaffin-like cell." ; rdfs:label "enterochromaffin-like cell" ; rdfs:subClassOf obo:CL_0000164, obo:CL_0002274 . obo:CL_0000505 obo:IAO_0000115 "A peptide hormone secreting cell that secretes substance P." ; oboInOwl:hasDbXref "ZFA:0009230" ; a owl:Class ; rdfs:label "substance P secreting cell" ; rdfs:subClassOf obo:CL_0000167 . obo:CL_0000506 obo:IAO_0000115 "An endorphine cell that secretes enkephalin." ; oboInOwl:hasDbXref "ZFA:0009231" ; a owl:Class ; rdfs:label "enkephalin secreting cell" ; rdfs:subClassOf obo:CL_0000507 . obo:CL_0000507 obo:IAO_0000115 "A peptide hormone secreting cell that secretes endorphin." ; oboInOwl:hasDbXref "ZFA:0009232" ; a owl:Class ; rdfs:label "endorphin secreting cell" ; rdfs:subClassOf obo:CL_0000167 . obo:CL_0000508 obo:IAO_0000115 "An endocrine cell found in the stomach and duodenum and is responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." ; oboInOwl:hasDbXref "BTO:0004108", "FMA:67609" ; oboInOwl:hasExactSynonym "G cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type G enteroendocrine cell" ; rdfs:subClassOf obo:CL_0000164, obo:CL_0000165, obo:CL_0000506, obo:CL_0000509 . obo:CL_0000509 obo:IAO_0000115 "A peptide hormone secreting cell that secretes gastrin." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "gastrin secreting cell" ; rdfs:subClassOf obo:CL_0000167 . obo:CL_0000510 obo:IAO_0000115 "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix." ; terms:description """Paneth cells are specialized epithelial cells that are primarily located at the bottom of the crypts of Lieberkühn in the small intestine, where they play a pivotal role in maintaining gut homeostasis. They have also been found in smaller numbers in the colonic crypts and other parts of the gastrointestinal tract. Paneth cells are characterized by large acidophilic granules, which take up most of the cytoplasmic volume, causing the nucleus to be pushed toward the base of the cell. Paneth cells function as a part of the innate immune system. The large granules inside the cells are filled with antimicrobial peptides, such as defensins and lysozymes. Upon bacterial intrusion or cellular signaling indicating a potential infection, Paneth cells release the granules containing the antimicrobial substances into the crypt lumen, effectively serving as the first line of defense against bacterial invasion within the gastrointestinal tract. In essence, Paneth cells serve as guardians, protecting the intestinal stem cells from harmful pathogens that may disturb the gut ecosystem. In addition to their primary role in immunity, Paneth cells are also crucial for supporting the stem cell niche in the intestinal crypts. They are located adjacent to Lgr5+ stem cells and secrete various growth factors such as EGF, TGF-alpha, Wnt3, and Notch ligand Dll4. These factors regulate the self-renewal and differentiation of these stem cells, which continuously replenish the intestinal epithelium. Consequently, any abnormality or dysfunction in Paneth cells could lead to a disturbance in gut homeostasis, possibly resulting in various illnesses such as inflammatory bowel disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:0000993", "FMA:62897" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "paneth cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000510" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000323, obo:CL_0002563, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011184 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005773 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005902 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_4047017 ] . obo:CL_0000511 obo:IAO_0000115 "A peptide hormone secreting cell that secretes androgen binding protein." ; a owl:Class ; rdfs:label "androgen binding protein secreting cell" ; rdfs:subClassOf obo:CL_0000154 . obo:CL_0000512 oboInOwl:consider obo:CL_0000151 ; a owl:Class ; rdfs:comment "The term paracrine describes a role of a secreted hormone. There are a vast number of cell types that could fit this description, however it is difficult to know every case where a secreted hormone has paracrine effects." ; rdfs:label "obsolete paracrine cell" ; owl:deprecated true . obo:CL_0000513 obo:IAO_0000115 "A precursor cell destined to differentiate into cardiac muscle cell." ; oboInOwl:hasDbXref "FMA:84797", "ZFA:0009234" ; oboInOwl:hasExactSynonym "cardiac muscle progenitor cell", "cardiomyocyte progenitor cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cardiac muscle myoblast" ; rdfs:subClassOf obo:CL_0002494, obo:CL_0010021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001133 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000056 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001133 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000746 ] ) ] . obo:CL_0000514 obo:IAO_0000115 "A precursor cell destined to differentiate into smooth muscle myocytes." ; terms:description """A precursor to the smooth muscle cell, the smooth muscle myoblast, is integral to various body systems, including the cardiovascular, gastrointestinal, and respiratory systems. Smooth muscle myoblasts arise from the differentiation of mesenchymal stem cells, a process tightly regulated by specific genetic factors and environmental signals. Their role extends to myogenesis, particularly in the formation of muscular tissue, especially during embryonic development. Smooth muscle myoblasts possess distinctive cellular characteristics. In contrast to skeletal muscle myoblasts, they do not fuse to create multinucleated fibers. Instead, they differentiate into individual, uninucleated smooth muscle cells. This differentiation unfolds in two distinct phases: proliferation, marked by rapid division to increase cell numbers, and differentiation, involving structural and functional transformation into mature smooth muscle cells. This intricate process is intricately mediated by various signaling molecules and transcription factors. Functionally, smooth muscle myoblasts and the mature muscle cells they generate play pivotal roles in various physiological processes. Smooth muscle cells orchestrate involuntary muscle responses and are integral to body systems that regulate blood flow, propel food along the digestive tract, and control airflow in the respiratory tract. These diverse functions underscore the significance of smooth muscle myoblasts in the body's growth, maintenance, and overall function. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:84798", "ZFA:0009235" ; oboInOwl:hasExactSynonym "myoblast, smooth muscle" ; oboInOwl:hasRelatedSynonym "satellite cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "smooth muscle myoblast" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000514" ; rdfs:subClassOf obo:CL_0000056, [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000192 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000056 [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000192 ] ) ] ; skos:prefLabel "smooth muscle myoblast" . obo:CL_0000515 obo:IAO_0000115 "A myoblast that differentiates into skeletal muscle fibers." ; oboInOwl:hasDbXref "FMA:84799", "ZFA:0009236" ; oboInOwl:hasExactSynonym "skeletal myoblast" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "skeletal muscle myoblast" ; rdfs:subClassOf obo:CL_0000056, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000355 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0008002 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000056 [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0008002 ] ) ] ; skos:prefLabel "skeletal muscle myoblast" . obo:CL_0000516 obo:IAO_0000115 "A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:54550", "ZFA:0009237" ; oboInOwl:hasExactSynonym "perineural satellite cell", "perineuronal satellite oligodendroglial cell", "satellite oligodendrocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "perineuronal satellite cell" ; rdfs:subClassOf obo:CL_0000123, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000339 ] . obo:CL_0000517 obo:IAO_0000115 "A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." ; oboInOwl:hasExactSynonym "lipophage" ; a owl:Class ; rdfs:label "macrophage derived foam cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000255, obo:CL_0000891, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000235 ] . obo:CL_0000518 obo:IAO_0000115 "A phagocyte in vertebrates that is able to phagocytosis." ; a owl:Class ; rdfs:label "phagocyte (sensu Vertebrata)" ; rdfs:subClassOf obo:CL_0000234, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_7742 ] . obo:CL_0000519 obo:IAO_0000115 "A phagocyte from organisms in the Nematoda or Protostomia clades." ; obo:RO_0002161 obo:NCBITaxon_33511 ; a owl:Class ; rdfs:label "phagocyte (sensu Nematoda and Protostomia)" ; rdfs:subClassOf obo:CL_0000234 . obo:CL_0000520 obo:RO_0002161 obo:NCBITaxon_2759 ; oboInOwl:hasDbXref "MESH:D011387" ; a owl:Class ; rdfs:label "prokaryotic cell" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0000521 obo:IAO_0000115 "Any cell that in taxon some Fungi." ; a owl:Class ; rdfs:label "fungal cell" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_4751 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_4751 ] ) ] . obo:CL_0000522 obo:IAO_0000115 "OBSOLETE: The reproductive structure of bacteria, fungi and cryptograms." ; a owl:Class ; rdfs:label "obsolete spore" ; owl:deprecated true . obo:CL_0000523 obo:IAO_0000115 "A cell from the inner layer of the trophoblast of the early mammalian embryo that gives rise to the outer surface and villi of the chorion. Mononuclear crytoblasts fuse to give rise to a multinuclear cytotrophoblast." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:83042" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mononuclear cytotrophoblast cell" ; rdfs:subClassOf obo:CL_0000351 . obo:CL_0000524 obo:IAO_0000115 "A cell, usually of bacteria or yeast, which has partially lost its cell wall." ; oboInOwl:hasExactSynonym "sphaeroplast" ; a owl:Class ; rdfs:label "spheroplast" ; rdfs:subClassOf obo:CL_0000371 . obo:CL_0000525 obo:IAO_0000115 "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:83043" ; oboInOwl:hasExactSynonym "syncytial trophoblast cell", "syncytiotrophoblastic cell" ; oboInOwl:hasRelatedSynonym "plasmidotrophoblast cell", "syntrophoblast cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "syncytiotrophoblast cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/2100" ; rdfs:subClassOf obo:CL_0000351, obo:CL_4052002, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000371 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000351 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] ) ] . obo:CL_0000526 obo:IAO_0000115 "A neuron which conveys sensory information centrally from the periphery." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:87653", "ZFA:0009238" ; oboInOwl:hasExactSynonym "input neuron" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "afferent neuron" ; rdfs:subClassOf obo:CL_0000540 ; skos:prefLabel "afferent neuron" . obo:CL_0000527 obo:IAO_0000115 "A neuron which sends impulses peripherally to activate muscles or secretory cells." ; oboInOwl:hasDbXref "ZFA:0009239" ; oboInOwl:hasExactSynonym "output neuron" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "efferent neuron" ; rdfs:subClassOf obo:CL_0000540 ; skos:prefLabel "efferent neuron" . obo:CL_0000528 obo:IAO_0000115 "A nerve cell where transmission is mediated by nitric oxide." ; oboInOwl:hasDbXref "FMA:84792", "ZFA:0009240" ; a owl:Class ; rdfs:label "nitrergic neuron" ; rdfs:subClassOf obo:CL_0000540 . obo:CL_0000529 oboInOwl:hasDbXref "ZFA:0009241" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "pigmented epithelial cell" ; rdfs:subClassOf obo:CL_0000710 . obo:CL_0000530 obo:IAO_0000115 "A neuron that develops during the early segmentation stages in teleosts, before the neural tube is formed." ; oboInOwl:hasDbXref "ZFA:0009242" ; a owl:Class ; rdfs:label "primary neuron (sensu Teleostei)" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000029, _:genid1931, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002240 ] . obo:CL_0000531 obo:IAO_0000115 "A primary neuron (sensu Teleostei) that has a sensory function." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "primary sensory neuron (sensu Teleostei)" ; rdfs:subClassOf obo:CL_0000101, obo:CL_0000530 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000101 obo:CL_0000530 ) ] . obo:CL_0000532 obo:IAO_0000115 "A primary motor neuron with its soma in the caudal region of a spinal cord. The axon of this motoneuron exit the spinal cord from one single point and innervates the lateral surface of ventral axial muscles" ; oboInOwl:hasDbXref "ZFA:0009243" ; oboInOwl:hasExactSynonym "CaP motorneuron" ; oboInOwl:hasRelatedSynonym "cap cell", "caudal primary motor neuron" ; a owl:Class ; rdfs:label "CAP motoneuron" ; rdfs:subClassOf obo:CL_0000533 . obo:CL_0000533 obo:IAO_0000115 "A primary neuron (sensu Teleostei) that has a motor function." ; oboInOwl:hasDbXref "ZFA:0009244" ; a owl:Class ; rdfs:label "primary motor neuron (sensu Teleostei)" ; rdfs:subClassOf obo:CL_0000530, obo:CL_0011001 . obo:CL_0000534 obo:IAO_0000115 "A primary neuron (sensu Teleostei) that is neither a sensory neuron or a motor neuron." ; oboInOwl:hasDbXref "ZFA:0009245" ; a owl:Class ; rdfs:label "primary interneuron (sensu Teleostei)" ; rdfs:subClassOf obo:CL_0000530, obo:CL_0005000 . obo:CL_0000535 obo:IAO_0000115 "A neuron of teleosts that develops later than a primary neuron, typically during the larval stages." ; oboInOwl:hasDbXref "ZFA:0009246" ; a owl:Class ; rdfs:label "secondary neuron (sensu Teleostei)" ; rdfs:subClassOf obo:CL_2000029, obo:UBERON_0010313, _:genid1949, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002240 ] . obo:CL_0000536 obo:IAO_0000115 "A secondary neuron (sensu Teleostei) that has a motor function." ; oboInOwl:hasDbXref "ZFA:0009247" ; a owl:Class ; rdfs:label "secondary motor neuron (sensu Teleostei)" ; rdfs:subClassOf obo:CL_0000535, obo:CL_0011001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000100 obo:CL_0000535 ) ] . obo:CL_0000537 obo:IAO_0000115 "Obsolete. Use PO:0020093 from Plant Ontology instead. OBSOLETE, use term from plant ontology. A cell located at the chalazal end of the mature embryo sac in angiosperms." ; obo:IAO_0100001 obo:PO_0020093 ; a owl:Class ; rdfs:label "obsolete antipodal cell" ; owl:deprecated true . obo:CL_0000538 obo:IAO_0000115 "Obsolete. Use PO:0000349 from Plant Ontology instead. A relatively unspecialized cell that will give rise to specialized cell types of the epidermis." ; obo:IAO_0100001 obo:PO_0000349 ; a owl:Class ; rdfs:label "obsolete epidermal initial" ; owl:deprecated true . obo:CL_0000539 obo:IAO_0000115 "OBSOLETE: A cell in a tissue that markedly differs in form, size, or contents from other cells in the same tissue." ; a owl:Class ; rdfs:label "obsolete idioblast" ; owl:deprecated true . obo:CL_0000540 obo:IAO_0000115 "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000938", "CALOHA:TS-0683", "FBbt:00005106", "FMA:54527", "VHOG:0001483", "WBbt:0003679", "ZFA:0009248" ; oboInOwl:hasExactSynonym "nerve cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma." ; rdfs:label "neuron" ; rdfs:subClassOf obo:CL_0000393, obo:CL_0000404, obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0019226 ] ; owl:equivalentClass [ a owl:Restriction ; owl:hasSelf true ; owl:onProperty obo:RO_0020104 ] ; skos:prefLabel "neuron" ; foaf:depiction "https://www.swissbiopics.org/api/image/Neuron_cells.svg"^^xsd:anyURI . obo:CL_0000541 obo:IAO_0000115 "A cell that originates from the neural crest and differentiates into a pigment cell." ; oboInOwl:hasDbXref "BTO:0003217", "FMA:83377", "ZFA:0009249" ; a owl:Class ; rdfs:comment "Derived from UBERON:0002342 neural crest." ; rdfs:label "melanoblast" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] . obo:CL_0000542 obo:IAO_0000115 "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000775", "CALOHA:TS-0583", "FMA:62863", "MESH:D008214", "VHOG:0001535", "ZFA:0009250" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Editors note: consider adding taxon constraint to vertebrata (PMID:18025161)" ; rdfs:label "lymphocyte" ; rdfs:subClassOf obo:CL_0000842, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017500 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000792 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0040072 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000051 ] ; owl:disjointWith obo:CL_0000766 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000738 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017500 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000792 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0040072 ] ) ] . obo:CL_0000543 obo:IAO_0000115 "Obsolete. Use PO:0000289 from Plant Ontology instead. One of the series of cellular components of a sieve tube. It shows a more or less pronounced differentiation between sieve plates (wide pores) and lateral sieve areas (narrow pores). Also sieve tube element and the obsolete sieve tube segment." ; obo:IAO_0100001 obo:PO_0000289 ; oboInOwl:hasExactSynonym "sieve tube element" ; a owl:Class ; rdfs:label "obsolete sieve tube member" ; owl:deprecated true . obo:CL_0000544 a owl:Class ; rdfs:label "slowly adapting mechanoreceptor cell" ; rdfs:subClassOf obo:CL_0000199 . obo:CL_0000545 obo:IAO_0000115 "A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0001678", "FMA:84382" ; oboInOwl:hasExactSynonym "T helper cells type 1", "T(H)-1 cell", "Th1 CD4+ T cell", "Th1 T cell", "Th1 T lymphocyte", "Th1 T-cell", "Th1 T-lymphocyte", "Th1 cell", "helper T cell type 1" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'Th1 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 1 T cells." ; rdfs:label "T-helper 1 cell" ; rdfs:subClassOf obo:CL_0000492, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001835 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001202 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001207 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000492 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001835 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001202 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001207 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] ) ] . obo:CL_0000546 obo:IAO_0000115 "A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0001679", "FMA:84385", "MESH:D018418" ; oboInOwl:hasExactSynonym "T helper cells type 2", "T(H)-2 cell", "Th2 T cell", "Th2 T lymphocyte", "Th2 T-cell", "Th2 T-lymphocyte", "Th2 cell", "helper T cell type 2" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell' (see CL:0001051), but includes the additional necessary and sufficient conditions to allow classification as a T-helper 2 T cell." ; rdfs:label "T-helper 2 cell" ; rdfs:subClassOf obo:CL_0000492, obo:CL_0001051, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001941 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032633 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000492 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001941 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001202 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001207 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032633 ] ) ] . obo:CL_0000547 obo:IAO_0000115 "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." ; oboInOwl:hasDbXref "FMA:83518" ; oboInOwl:hasExactSynonym "rubriblast" ; oboInOwl:hasRelatedSynonym "pronormoblast" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset ; a owl:Class ; rdfs:label "proerythroblast" ; rdfs:subClassOf obo:CL_0000764, obo:CL_0002242, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017503 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005730 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0040072 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001945 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000038 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000764 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017503 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005730 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002505 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0040072 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001945 ] ) ] ; skos:prefLabel "proerythroblast" . obo:CL_0000548 obo:IAO_0000115 "OBSOLETE. A native cell that is part of some Metazoa." ; obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000000 ; oboInOwl:hasExactSynonym "metazoan cell" ; oboInOwl:inSubset ubprop:_upper_level ; a owl:Class ; rdfs:label "obsolete animal cell" ; owl:deprecated true ; foaf:depiction "https://www.swissbiopics.org/api/image/Animal_cells.svg"^^xsd:anyURI . obo:CL_0000549 obo:IAO_0000115 "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." ; oboInOwl:hasDbXref "FMA:83505", "ZFA:0005236" ; oboInOwl:hasExactSynonym "basophilic normoblast", "early erythroblast", "early normoblast", "prorubricyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "basophilic erythroblast" ; rdfs:subClassOf obo:CL_0000765, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017503 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000792 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001945 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000765 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017503 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000792 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001945 ] ) ] ; skos:prefLabel "basophilic erythroblast" . obo:CL_0000550 obo:IAO_0000115 "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." ; oboInOwl:hasDbXref "FMA:83506", "ZFA:0005241" ; oboInOwl:hasExactSynonym "intermediate erythroblast", "intermediate normoblast", "polychromatic erythroblast", "polychromatic normoblast", "polychromatophilic normoblast", "rubricyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "polychromatophilic erythroblast" ; rdfs:subClassOf obo:CL_0000765, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017504 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000792 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001945 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000549 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000765 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017504 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000792 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001945 ] ) ] ; skos:prefLabel "polychromatophilic erythroblast" . obo:CL_0000551 a owl:Class ; rdfs:label "unimodal nocireceptor" ; rdfs:subClassOf obo:CL_0000198 . obo:CL_0000552 obo:IAO_0000115 "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." ; oboInOwl:hasDbXref "FMA:84646" ; oboInOwl:hasExactSynonym "acidophilic erythroblast", "eosinophilic erythroblast", "late erythoblast", "orthochromatic normoblast", "pyknotic eto enrythroblast" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "orthochromatic erythroblast" ; rdfs:subClassOf obo:CL_0000765, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017502 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0030263 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000550 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000765 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017502 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0030263 ] ) ] ; skos:prefLabel "orthochromatic erythroblast" . obo:CL_0000553 obo:IAO_0000115 "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0001164", "CALOHA:TS-0610", "FMA:84235", "MESH:D055016" ; oboInOwl:hasExactSynonym "CFU-Meg", "Meg-CFC", "MkP", "colony-forming unit-megakaryocyte", "megacaryoblast", "megacaryocyte progenitor cell", "megakaryoblast", "megakaryocytic progenitor cell" ; oboInOwl:hasRelatedSynonym "promegacaryocyte", "promegakaryocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative." ; rdfs:label "megakaryocyte progenitor cell" ; rdfs:subClassOf obo:CL_0000763, obo:CL_0000839, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000050 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007113 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030219 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000839 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030219 ] ) ] . obo:CL_0000554 obo:IAO_0000115 "A peptide hormone secreting cell that secretes gastrin stimulating hormone." ; a owl:Class ; rdfs:label "gastrin stimulating hormone secreting cell" ; rdfs:subClassOf obo:CL_0000167 . obo:CL_0000555 obo:IAO_0100001 obo:CL_4023161 ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "obsolete neuronal brush cell" ; owl:deprecated true . obo:CL_0000556 obo:IAO_0000115 "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000843", "CALOHA:TS-0611", "FMA:83555" ; oboInOwl:hasExactSynonym "megacaryocyte", "megalocaryocyte", "megalokaryocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Megakaryocytes are reportedly CD181-positive and CD182-positive." ; rdfs:label "megakaryocyte" ; rdfs:subClassOf obo:CL_0000763, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001393 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000553 ] ; owl:disjointWith obo:CL_0000764 . obo:CL_0000557 obo:IAO_0000115 "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Granulocyte monocyte progenitor cells (GMP cells), originating from hematopoietic stem cells in the bone marrow, are a critical intermediate in myeloid cell development. Positioned at a key differentiation juncture, these cells exhibit bidirectional potential, giving rise to both granulocyte and monocyte lineages. Their primary role is to generate mature granulocytes and monocytes, essential components of the body's innate immunity and inflammatory responses. Granulocytes, such as neutrophils, eosinophils, and basophils, contribute to the first line of defense against infections by migrating to the infection site and phagocytosing pathogens. Monocytes can differentiate into macrophages or dendritic cells, playing diverse roles in immune responses. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasBroadSynonym "CFU-C , Colony forming unit in culture" ; oboInOwl:hasDbXref "ZFA:0009251" ; oboInOwl:hasExactSynonym "colony forming unit granulocyte macrophage", "granulocyte-macrophage progenitor", "granulocyte/monocyte precursor", "granulocyte/monocyte progenitor" ; oboInOwl:hasRelatedSynonym "CFU-GM", "GMP" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative." ; rdfs:label "granulocyte monocyte progenitor cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000557" ; rdfs:subClassOf obo:CL_0000763, obo:CL_0001012, obo:CL_1001610, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000007857 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000007858 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001865 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030225 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030851 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002032 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000007857 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000007858 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030225 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030851 ] ) ] . obo:CL_0000558 obo:IAO_0000115 "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." ; oboInOwl:hasDbXref "BTO:0001173", "CALOHA:TS-0864", "MESH:D012156", "ZFA:0009252" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset ; a owl:Class ; rdfs:label "reticulocyte" ; rdfs:subClassOf obo:CL_0000764, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001945 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000552 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0071971 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000764 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001945 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0071971 ] ) ] ; skos:prefLabel "reticulocyte" . obo:CL_0000559 obo:IAO_0000115 "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0004657", "FMA:83551", "ZFA:0009253" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid." ; rdfs:label "promonocyte" ; rdfs:subClassOf obo:CL_0000763, obo:CL_0002194, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042582 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000040 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002194 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042582 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030224 ] ) ] . obo:CL_0000560 obo:IAO_0000115 "A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil. These cells are fMLP receptor-positive, CD11b-positive, CD35-negative, and CD49d-negative." ; oboInOwl:hasBroadSynonym "band", "band cell", "band form", "stab cell" ; oboInOwl:hasDbXref "ZFA:0009254" ; oboInOwl:hasExactSynonym "rod neutrophil" ; a owl:Class ; rdfs:comment "Found in the Band 1 fraction." ; rdfs:label "band form neutrophil" ; rdfs:subClassOf obo:CL_0000096, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017506 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000009129 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000010543 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001337 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001580 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000582 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000096 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017506 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007597 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000009978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000010799 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000009129 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000010543 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001337 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001580 ] ) ] . obo:CL_0000561 obo:IAO_0000115 "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0004044", "FMA:67766", "ZFA:0009255" ; oboInOwl:hasExactSynonym "amacrine neuron" ; oboInOwl:hasRelatedSynonym "AC", "ACs" ; oboInOwl:inSubset cl:cellxgene_subset, cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "amacrine cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000099, obo:CL_0009004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_0000740 ] . obo:CL_0000562 obo:IAO_0000115 "An erythrocyte having a nucleus." ; oboInOwl:hasBroadSynonym "RBC", "red blood cell" ; oboInOwl:hasDbXref "ZFA:0009256" ; a owl:Class ; rdfs:label "nucleate erythrocyte" ; rdfs:subClassOf obo:CL_0000232, obo:CL_0002242, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002421 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000232 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002505 ] ) ] . obo:CL_0000563 obo:IAO_0000115 "A rounded, inactive form that certain bacteria assume under conditions of extreme temperature, dryness, or lack of food. The bacterium develops a waterproof cell wall that protects it from being dried out or damaged." ; oboInOwl:hasDbXref "BTO:0002779" ; oboInOwl:hasExactSynonym "bacterial spore" ; a owl:Class ; rdfs:label "endospore" ; rdfs:subClassOf obo:CL_0000520 . obo:CL_0000564 obo:IAO_0000115 "A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression." ; oboInOwl:hasDbXref "FMA:84196", "ZFA:0009257" ; oboInOwl:hasExactSynonym "neutrophilic premyelocyte", "neutrophilic progranulocyte" ; a owl:Class ; rdfs:comment "These cells are CD11b-negative, CD15-positive, CD16-negative, CD49d-positive, CD68-positive, CD35-negative, and fMLP receptor-negative. They are found in the Band 3 fraction." ; rdfs:label "neutrophilic promyelocyte" ; rdfs:subClassOf obo:CL_0000834, obo:CL_0000836, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000010543 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000014362 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000009978 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000042 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000836 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000010543 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000014362 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000009978 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030223 ] ) ] . obo:CL_0000565 obo:IAO_0000115 "A cell found in fat bodies whose primary function is intermediary metabolism." ; a owl:Class ; rdfs:label "fat body cell" ; rdfs:subClassOf obo:CL_0000325 . obo:CL_0000566 obo:IAO_0000115 "A mesenchymal stem cell capable of developing into blood vessel endothelium." ; oboInOwl:hasDbXref "ZFA:0009258" ; oboInOwl:hasExactSynonym "angioblast", "chondroplast" ; a owl:Class ; rdfs:comment "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive." ; rdfs:label "angioblastic mesenchymal cell" ; rdfs:subClassOf obo:CL_0000134, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001444 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002112 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000016043 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000134 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001444 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002112 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000016043 ] ) ] ; skos:prefLabel "angioblastic mesenchymal cell" . obo:CL_0000567 a owl:Class ; rdfs:label "polymodal nocireceptor" ; rdfs:subClassOf obo:CL_0000198 . obo:CL_0000568 obo:IAO_0000115 "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." ; oboInOwl:hasDbXref "BTO:0003866", "FMA:83114", "MESH:D001078" ; oboInOwl:hasExactSynonym "APUD cell" ; a owl:Class ; rdfs:label "amine precursor uptake and decarboxylation cell" ; rdfs:subClassOf obo:CL_0000165 ; skos:prefLabel "amine precursor uptake and decarboxylation cell" . obo:CL_0000569 obo:IAO_0000115 "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." ; oboInOwl:hasDbXref "ZFA:0009259" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cardiac mesenchymal cell" ; rdfs:subClassOf obo:CL_0008019, obo:CL_2000073, [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0002494 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0008019 [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0002494 ] ) ] . obo:CL_0000570 obo:IAO_0000115 "A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. This cell expresses a form of the neural cell adhesion molecule (N-CAM) on its surface and secretes calcitonin and serotonin (5-hydroxytryptamine)." ; oboInOwl:hasDbXref "FMA:68653", "SCTID:176770005", "ZFA:0009260" ; oboInOwl:hasExactSynonym "C cell", "C cell of thyroid gland", "clear cell of thyroid gland", "parafollicular cell of thyroid gland", "thyroid parafollicular cell" ; a owl:Class ; rdfs:label "parafollicular cell" ; rdfs:subClassOf obo:CL_0000163, obo:CL_0000443, obo:CL_0000458, obo:CL_0000710, obo:CL_0002257, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001747 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001820 [ a owl:Restriction ; owl:onProperty obo:RO_0002339 ; owl:someValuesFrom obo:UBERON_0001009 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0036161 [ a owl:Restriction ; owl:onProperty obo:RO_0002339 ; owl:someValuesFrom obo:UBERON_0001009 ] ) ] ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000710 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001820 [ a owl:Restriction ; owl:onProperty obo:RO_0002339 ; owl:someValuesFrom obo:UBERON_0001009 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0036161 [ a owl:Restriction ; owl:onProperty obo:RO_0002339 ; owl:someValuesFrom obo:UBERON_0001009 ] ) ] ] ) ] . obo:CL_0000571 obo:IAO_0000115 "A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light." ; oboInOwl:hasDbXref "ZFA:0009261" ; a owl:Class ; rdfs:label "leucophore" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000147, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0005003 ] . obo:CL_0000572 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000148 ; a owl:Class ; owl:deprecated true . obo:CL_0000573 obo:IAO_0000115 "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0001036", "CALOHA:TS-0866", "FMA:67748", "ZFA:0009262" ; oboInOwl:hasRelatedSynonym "cone" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "retinal cone cell" ; rdfs:subClassOf obo:CL_0010009, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002672 ] ; skos:prefLabel "retinal cone cell" . obo:CL_0000574 obo:IAO_0000115 "A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance." ; oboInOwl:hasDbXref "ZFA:0009263" ; a owl:Class ; rdfs:label "erythrophore" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000147, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0005004 ] . obo:CL_0000575 obo:IAO_0000115 "An epithelial cell of the cornea." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0004298", "CALOHA:TS-0173", "FMA:70551", "ZFA:0009264" ; oboInOwl:hasExactSynonym "epithelial cell of cornea" ; oboInOwl:inSubset cl:cellxgene_subset, cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "corneal epithelial cell" ; rdfs:subClassOf obo:CL_0000076, obo:CL_0002159, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001772 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001772 ] ) ] . obo:CL_0000576 obo:IAO_0000115 "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000876", "CALOHA:TS-0638", "FMA:62864", "ZFA:0009265" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid." ; rdfs:label "monocyte" ; rdfs:subClassOf obo:CL_0000113, obo:CL_0000766, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000559 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030225 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030316 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043011 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000766 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030225 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030316 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043011 ] ) ] . obo:CL_0000577 obo:IAO_0000115 "A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain)." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Type EC enteroendocrine cells, also known as enterochromaffin cells, are a vital hormone-secreting cell type found in the gastrointestinal tract. These cells are named after their location in the intestines (“entero”) and because they are stainable by chromium salts (“chromaffin”). The primary function of type EC enteroendocrine cells is to act as chemosensors and lies in their capacity to produce and secrete serotonin, also known as 5-hydroxytryptamine (5-HT). Serotonin is a neurotransmitter that plays a significant role in modulating motility, secretion, vasodilation, perception of pain, and appetite in the gastrointestinal system. However, its function is not limited to the gastrointestinal tract; once secreted, serotonin is distributed via the bloodstream and contributes to regulating mood, appetite, and sleep in the brain. Via specific chemosensory receptors type EC enteroendocrine cells are able to respond to various environmental, metabolic, and homeostatic stimuli and transduce information from the gut to the nervous system: Food intake, particularly the ingestion of fats and carbohydrates, prompts these cells to produce and release serotonin; the mechanical stimulus of food in the lumen can also trigger release. The distribution, function, and responsiveness of type EC cells reveal them as a crucial link between the intestinal environment, the nervous system, and the regulation of numerous bodily functions. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:62934", "FMA:83132", "MESH:D004759" ; oboInOwl:hasExactSynonym "Kulchitsky cell", "argentaffin cell", "enterochromaffin cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "type EC enteroendocrine cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000577" ; rdfs:subClassOf obo:CL_0000164, obo:CL_0000166, obo:CL_0000458, obo:CL_0000506, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004786 ] . obo:CL_0000578 obo:IAO_0000115 "A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure." ; a owl:Class ; rdfs:comment "This class has been re-labeled to imply reference only to in vitro experimentally modified cells, similarly, the definition has been slightly updated to reflect this. 'experimentally modified cell' refers only to cells in vitro, and not modified in vivo/in environment cells. There is currently no class representing unmodified in vitro cells (other than the parent 'cell in vitro'), or a class representing modified native cells. More granular subclassing of experimentally modified cell can be found in ReO. MHB 1.12.12" ; rdfs:label "experimentally modified cell in vitro" ; rdfs:subClassOf obo:CL_0001034 . obo:CL_0000579 obo:IAO_0000115 "A follicle cell that migrates from the anterior pole of the insect egg chamber to the anterior of the oocyte where they participate in the formation of the micropyle." ; oboInOwl:hasDbXref "FBbt:00004905" ; a owl:Class ; rdfs:label "border follicle cell" ; rdfs:subClassOf obo:CL_0000477 . obo:CL_0000580 obo:IAO_0000115 "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. This cell type is CD13-positive, CD16-negative, integrin alpha-M-positive, CD15-positive, CD33-positive, CD24-positive, C/EBP-a-positive, C/EBPe-positive, PU.1-positive, lactotransferrin-positive, myeloperoxidase-positive and NGAL-positive." ; oboInOwl:hasDbXref "BTO:0003455", "FMA:83540", "ZFA:0009266" ; a owl:Class ; rdfs:comment "These cells are also CD15-positive, CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction." ; rdfs:label "neutrophilic myelocyte" ; rdfs:subClassOf obo:CL_0000776, obo:CL_0002087, obo:CL_0002193, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017502 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042582 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005310 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000009725 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000009978 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000010543 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0070820 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001483 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001456 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001892 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002031 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000776 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017502 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042582 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005310 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000009725 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000009978 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000010543 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0070820 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001892 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002031 ] ) ] . obo:CL_0000581 obo:IAO_0000115 "A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive." ; oboInOwl:hasDbXref "BTO:0001034", "FMA:83025", "ZFA:0009267" ; a owl:Class ; rdfs:comment "Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+." ; rdfs:label "peritoneal macrophage" ; rdfs:subClassOf obo:CL_0000864, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001179 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001807 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002064 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000006172 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042742 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001813 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002062 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000864 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001179 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001807 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002064 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000006172 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042742 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002062 ] ) ] . obo:CL_0000582 obo:IAO_0000115 "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin." ; oboInOwl:hasDbXref "FMA:84197", "ZFA:0009268" ; oboInOwl:hasExactSynonym "juvenile neutrophil" ; a owl:Class ; rdfs:comment "These cells are also CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction." ; rdfs:label "neutrophilic metamyelocyte" ; rdfs:subClassOf obo:CL_0000776, obo:CL_0002192, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017502 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017507 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000792 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042582 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0070820 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005310 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000009725 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000009978 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000010543 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001580 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001456 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001892 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002031 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000580 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000776 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017502 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017507 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000792 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042582 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0070820 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005310 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000009725 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000009978 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000010543 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001580 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001892 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002031 ] ) ] . obo:CL_0000583 obo:IAO_0000115 "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Alveolar macrophages are unique tissue-resident macrophages found in the lungs, specifically in the air sacs or alveoli where gas exchange occurs. They are characterized by specific surface markers including: F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative. These specialized immune cells form a crucial part of the body's defense mechanism, playing important roles in pulmonary health and homeostasis. They are the first line of defense in the pulmonary immune response, acting as scavengers that patrol the alveoli and engulf foreign particles like bacteria, dust, and other debris that enter the lungs through inhalation. The primary function of these alveolar macrophages is phagocytosis, whereby they consume and digest foreign substances, dead cells, and other particulates. In the lung, alveolar macrophages are also responsible for clearing surfactant. Additionally, alveolar macrophages also play an integral role in initiating the immune response, as they secrete several pro-inflammatory cytokines and chemokines that recruit other immune cells to the site of infection or inflammation. Beyond their role in host defense, alveolar macrophages contribute to tissue remodeling and wound repair in the lungs, aiding in maintaining lung integrity. They also regulate local inflammation and control the immune response to prevent excessive inflammation that may be harmful. However, an imbalance in the function of alveolar macrophages can contribute to various lung diseases. Abnormal alveolar macrophage activation has been implicated in chronic inflammatory diseases such as emphysema, asthma, and fibrosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:0000802", "CALOHA:TS-0030", "FMA:83023" ; oboInOwl:hasExactSynonym "dust cell" ; oboInOwl:hasRelatedSynonym "MF.Lu" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-.", "The marker set MSR1, FABP4 can identify the Human cell type alveolar macrophage in the lung with a confidence of 0.80 (NS-Forest FBeta value)." ; rdfs:label "alveolar macrophage" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000583" ; rdfs:subClassOf obo:CL_0000864, obo:CL_1001603, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001206 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_8850000 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001013 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001807 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001931 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002064 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002972 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000864 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001206 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_8850000 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001807 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001931 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002064 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002972 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0019882 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ] ) ] . obo:CL_0000584 obo:IAO_0000115 "An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000398", "FMA:62122", "MESH:D020895", "ZFA:0009269" ; oboInOwl:hasNarrowSynonym "differentiated enterocyte", "mature enterocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "enterocyte" ; rdfs:subClassOf obo:CL_0000239, obo:CL_0000677, obo:CL_0002563 . obo:CL_0000585 obo:IAO_0000115 "OBSOLETE: A class of lymphocytes characterized by the lack of surface markers specific for either T or B cells." ; a owl:Class ; rdfs:comment "This term is rather archaic; consider using 'natural killer cell ; CL:0000623', 'pro-B cell ; CL:0000826', 'pro-T cell ; CL:0000827', or other appropriate lymphocyte-related term depending on the context." ; rdfs:label "obsolete null cell" ; owl:deprecated true . obo:CL_0000586 obo:IAO_0000115 "The reproductive cell in multicellular organisms." ; oboInOwl:hasDbXref "BTO:0000535", "NCIT:C12597", "VHOG:0001534", "WBbt:0006796" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "germ cell" ; rdfs:subClassOf obo:CL_0000039, [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0009566 ] ; skos:prefLabel "germ cell" . obo:CL_0000587 obo:IAO_0000115 "A thermoreceptor cell that detects reduced temperatures." ; a owl:Class ; rdfs:label "cold sensing thermoreceptor cell" ; rdfs:subClassOf obo:CL_0000205 . obo:CL_0000588 obo:IAO_0000115 "A specialized osteoclast associated with the absorption and removal of cementum." ; oboInOwl:hasDbXref "BTO:0002516", "FMA:83027", "ZFA:0009270" ; a owl:Class ; rdfs:label "odontoclast" ; rdfs:subClassOf obo:CL_0000092, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042483 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000092 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042483 ] ) ] . obo:CL_0000589 obo:IAO_0000115 "A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated." ; oboInOwl:hasBroadSynonym "inner hair cell" ; oboInOwl:hasDbXref "BTO:0003667", "FMA:62365" ; a owl:Class ; rdfs:label "cochlear inner hair cell" ; rdfs:subClassOf obo:CL_4023120 . obo:CL_0000590 obo:IAO_0000115 "A progesterone secreting cell in the corpus luteum that develops from theca cells." ; oboInOwl:hasDbXref "BTO:0002850", "FMA:18690" ; oboInOwl:hasExactSynonym "small lutein cell", "theca lutein cell" ; a owl:Class ; rdfs:label "small luteal cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000175, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000503 ] . obo:CL_0000591 obo:IAO_0000115 "A thermoreceptor cell that detects increased temperatures." ; a owl:Class ; rdfs:label "warmth sensing thermoreceptor cell" ; rdfs:subClassOf obo:CL_0000205 . obo:CL_0000592 obo:IAO_0000115 "A large, progesterone secreting cell in the corpus luteum that develops from the granulosa cells." ; oboInOwl:hasDbXref "FMA:18689" ; oboInOwl:hasExactSynonym "granulosa lutein cell" ; oboInOwl:hasRelatedSynonym "granulosoluteocytus" ; a owl:Class ; rdfs:label "large luteal cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000175, obo:CL_0000177, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000501 ] . obo:CL_0000593 obo:IAO_0000115 "A steroid hormone secreting cell that secretes androgen." ; oboInOwl:hasDbXref "ZFA:0009271" ; a owl:Class ; rdfs:label "androgen secreting cell" ; rdfs:subClassOf obo:CL_0000174, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035935 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035935 ] ) ] . obo:CL_0000594 obo:IAO_0000115 "An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers." ; terms:description """Skeletal muscle satellite cells (SMSCs) are a type of adult stem cell that nestles on the outer surface of the myofiber, positioned between the sarcolemma (plasma membrane of the muscle cell) and peripheral basement membrane. The primary function of SMSCs lies in their capacity to facilitate the growth and repair of damaged skeletal muscle. Upon muscle injury or trauma, these normally quiescent cells activate, proliferate, and differentiate into myoblasts. These myoblasts subsequently mature and fuse to form myotubes, which ultimately help in the repair and rebuilding of muscle fibers. This response is an integral part of the skeletal muscle's ability to recover from injury and adapt to enhanced or changing physical demands, thereby maintaining and improving muscle function. Furthermore, SMSCs also contribute to hypertrophic muscle growth due to resistance exercise and endurance training, with the notable feature of their multi-nucleated nature resulting from the fusion of differentiated myoblasts. The additional nuclei support enhanced protein synthesis, thus allowing the muscle fibers to grow and strengthen in response to exercise. In aging and in diseases, the number or functionality of these cells can decrease, leading to impaired muscle regeneration and progressive muscle weakness. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "ZFA:0009272" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Skeletal muscle satellite cells are not traditionally referred to as myoblasts. They are a heterogeneous population whose division, following activiation, contributes to the formation of skeletal muscle fibers and to maintenance of the skeletal muscle statelite cell population." ; rdfs:label "skeletal muscle satellite cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000594" ; rdfs:subClassOf obo:CL_0000188, obo:CL_0000680 . obo:CL_0000595 obo:IAO_0000115 "An erythrocyte lacking a nucleus." ; oboInOwl:hasBroadSynonym "red blood cell" ; oboInOwl:hasRelatedSynonym "RBC" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "enucleate erythrocyte" ; rdfs:subClassOf obo:CL_0000225, obo:CL_0000232, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002422 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000232 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001405 ] ) ] . obo:CL_0000596 obo:IAO_0000115 "A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature." ; oboInOwl:hasDbXref "FAO:0000017" ; oboInOwl:hasExactSynonym "meiotically-derived spore" ; a owl:Class ; rdfs:label "sexual spore" ; rdfs:subClassOf obo:CL_0002369 . obo:CL_0000597 obo:IAO_0000115 "The smaller of two types of asexual spores formed by some fungi. An ovoid to pear-shaped asexual spore that contains very little cytoplasm and organelles, is uninucleate, and forms in vegetative hypae within a mycelium. Micronidia are extruded from the hyphal cell wall." ; oboInOwl:hasDbXref "FAO:0000028" ; a owl:Class ; rdfs:label "microconidium" ; rdfs:subClassOf obo:CL_0002381 . obo:CL_0000598 obo:IAO_0000115 "Pyramidal neurons have a pyramid-shaped soma with a single axon, a large apical dendrite and multiple basal dendrites. The apex and an apical dendrite typically point toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala." ; oboInOwl:hasDbXref "BTO:0003102", "FMA:67310", "FMA:86775", "NIFSTD:sao862606388", "ZFA:0009273" ; oboInOwl:hasExactSynonym "projection neuron", "pyramidal cell" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:label "pyramidal neuron" ; rdfs:subClassOf obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070015 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070015 ] ) ] ; skos:prefLabel "pyramidal neuron" . obo:CL_0000599 obo:IAO_0000115 "An asexual, nonmotile spore formed by higher fungi; conidia are usually made from the side or tip of specialized sporogenous cells and do not form by progressive cleavage of the cytoplasm." ; oboInOwl:hasDbXref "BTO:0000283", "FAO:0000024" ; a owl:Class ; rdfs:label "conidium" ; rdfs:subClassOf obo:CL_0000605 . obo:CL_0000600 obo:IAO_0000115 "A fungal cell with two or more genetically distinct nuclei." ; a owl:Class ; rdfs:label "heterokaryon" ; rdfs:subClassOf obo:CL_0000228, obo:CL_0000521 . obo:CL_0000601 obo:IAO_0000115 "A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea." ; oboInOwl:hasDbXref "BTO:0003666", "FMA:62366" ; a owl:Class ; rdfs:label "cochlear outer hair cell" ; rdfs:subClassOf obo:CL_4023120 . obo:CL_0000602 obo:IAO_0000115 "A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls." ; oboInOwl:hasDbXref "ZFA:0009274" ; a owl:Class ; rdfs:label "pressoreceptor cell" ; rdfs:subClassOf obo:CL_1000082 . obo:CL_0000603 obo:IAO_0000115 "A fungal cell with two genetically distinct haploid nuclei." ; a owl:Class ; rdfs:label "dikaryon" ; rdfs:subClassOf obo:CL_0000227, obo:CL_0000600 . obo:CL_0000604 obo:IAO_0000115 "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0001024", "CALOHA:TS-0870", "FMA:67747", "ZFA:0009275" ; oboInOwl:hasRelatedSynonym "rod" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "retinal rod cell" ; rdfs:subClassOf obo:CL_0010009, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002672 ] ; skos:prefLabel "retinal rod cell" . obo:CL_0000605 obo:IAO_0000115 "A spore formed following mitosis or mitoses." ; oboInOwl:hasDbXref "FAO:0000023" ; a owl:Class ; rdfs:label "fungal asexual spore" ; rdfs:subClassOf obo:CL_0002369 . obo:CL_0000606 obo:IAO_0000115 "The larger of two types of asexual spores formed by some fungi; usually round or oblong." ; oboInOwl:hasDbXref "FAO:0000038" ; a owl:Class ; rdfs:label "macroconidium" ; rdfs:subClassOf obo:CL_0000599 . obo:CL_0000607 obo:IAO_0000115 "A thick walled spore that stores and protects one or more nuclei following sexual reproduction in an Ascomycete." ; oboInOwl:hasDbXref "BTO:0000097", "FAO:0000020" ; a owl:Class ; rdfs:label "ascospore" ; rdfs:subClassOf obo:CL_0000596 . obo:CL_0000608 obo:IAO_0000115 "A thick walled, sexual, resting spore formed by Zygomycetes; sometimes refers to the spore and the multi-layered cell wall that encloses the spore, the zygosporangium." ; oboInOwl:hasDbXref "FAO:0000040" ; a owl:Class ; rdfs:label "zygospore" ; rdfs:subClassOf obo:CL_0000596 . obo:CL_0000609 obo:IAO_0000115 "A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem." ; oboInOwl:hasDbXref "FMA:62351" ; oboInOwl:hasExactSynonym "vestibular receptor cell" ; a owl:Class ; rdfs:label "vestibular hair cell" ; rdfs:subClassOf obo:CL_0002374 . obo:CL_0000610 oboInOwl:consider "PO:0009002" ; a owl:Class ; rdfs:comment "This term was obsoleted as it is redundant with PO:0009002 in the cell ontology (PO)" ; rdfs:label "obsolete plant cell" ; owl:deprecated true . obo:CL_0000611 obo:IAO_0000115 "Any granulocytopoietic cell that has part some transcription factor PU.1 and has part some CCAAT/enhancer-binding protein alpha and has part some erythroid transcription factor and lacks plasma membrane part some CD19 molecule and lacks plasma membrane part some CD4 molecule and lacks plasma membrane part some integrin alpha-M and lacks plasma membrane part some CD3 epsilon and lacks plasma membrane part some neural cell adhesion molecule 1 and lacks plasma membrane part some CD2 molecule and lacks plasma membrane part some T-cell surface glycoprotein CD8 alpha chain and lacks plasma membrane part some membrane-spanning 4-domains subfamily A member 1 and lacks plasma membrane part some T-cell surface glycoprotein CD5 and lacks plasma membrane part some CD14 molecule and lacks plasma membrane part some lymphocyte antigen 6G and lacks plasma membrane part some lymphocyte antigen 76 (mouse) and has plasma membrane part some CD34 molecule and has plasma membrane part some ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 and has plasma membrane part some interleukin-3 receptor class 2 alpha chain and has plasma membrane part some interleukin-5 receptor subunit alpha and has plasma membrane part some mast/stem cell growth factor receptor and is capable of some eosinophil differentiation." ; oboInOwl:hasRelatedSynonym "CFU-Eo", "EoP", "colony forming unit eosinophil", "eosinophil stem cell" ; a owl:Class ; rdfs:comment "These cells are CD34-positive, CD45RA-negative, CD71-negative, and lineage-negative (CD2, CD3 epsilon, CD4, CD5, CD8a, CD14, CD19, CD20, integrin alpha-M, NCAM-1, SCA-1, Ly6G, Ly76)." ; rdfs:label "eosinophil progenitor cell" ; rdfs:subClassOf obo:CL_0000763, obo:CL_0002191, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001865 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001867 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000557 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030222 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002191 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030222 ] ) ] . obo:CL_0000612 obo:IAO_0000115 "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive." ; oboInOwl:hasDbXref "BTO:0003454", "FMA:83542" ; a owl:Class ; rdfs:label "eosinophilic myelocyte" ; rdfs:subClassOf obo:CL_0000772, obo:CL_0002087, obo:CL_0002193, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042582 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0070820 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001483 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001456 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001892 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002031 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000772 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042582 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0070820 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001892 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002031 ] ) ] . obo:CL_0000613 obo:IAO_0000115 "A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa." ; oboInOwl:hasExactSynonym "BaP" ; oboInOwl:hasRelatedSynonym "CFU-Bas", "basophilic stem cell", "colony forming unit basophil" ; a owl:Class ; rdfs:comment "BaP are also CD13-low and integrin beta-7-low. They are lin-negative (CD2, CD3e, CD4, CD5, CD8, CD11b, CD14, CD19, CD20, ly6g, ly76, and NCAM-1). They also lack expression of mast cell protease 1 (MCP-1) and microphthalmia-associated transcription factor (mitf)." ; rdfs:label "basophil progenitor cell" ; rdfs:subClassOf obo:CL_0000763, obo:CL_0002191, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007858 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002028 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030221 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000007431 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000016401 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002191 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007858 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030221 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000007431 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000016401 ] ) ] . obo:CL_0000614 obo:IAO_0000115 "A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive." ; oboInOwl:hasDbXref "BTO:0003456", "FMA:83543" ; a owl:Class ; rdfs:label "basophilic myelocyte" ; rdfs:subClassOf obo:CL_0000768, obo:CL_0002087, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042582 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0005730 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0070820 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001483 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001456 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001892 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002031 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000768 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042582 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0005730 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0070820 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001892 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002031 ] ) ] . obo:CL_0000615 obo:IAO_0000115 "A thick walled spore containing one or more haploid nuclei produced by sexual reproduction in an Basidiomycete; formed externally on extrusions of the basidium." ; oboInOwl:hasDbXref "BTO:0002166", "FAO:0000021" ; a owl:Class ; rdfs:label "basidiospore" ; rdfs:subClassOf obo:CL_0000596 . obo:CL_0000616 obo:IAO_0000115 "OBSOLETE: A walled spore produced in a sporangium." ; a owl:Class ; rdfs:label "obsolete sporangiospore" ; owl:deprecated true . obo:CL_0000617 obo:IAO_0000115 "A neuron that uses GABA as a vesicular neurotransmitter" ; oboInOwl:hasDbXref "FBbt:00007228", "FMA:84788", "MESH:D059330", "WBbt:0005190", "ZFA:0009276" ; oboInOwl:hasExactSynonym "GABA-ergic neuron" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "GABAergic neuron" ; rdfs:subClassOf obo:CL_0000151, obo:CL_0000540, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ) ] ; skos:prefLabel "GABAergic neuron" . obo:CL_0000618 a owl:Class ; rdfs:label "sheath cell" ; rdfs:subClassOf obo:CL_0000075 . obo:CL_0000619 oboInOwl:hasExactSynonym "support cell (sensu Nematoda)" ; a owl:Class ; rdfs:label "supporting cell (sensu Nematoda)" ; rdfs:subClassOf obo:CL_0000378 . obo:CL_0000620 obo:IAO_0000115 "OBSOLETE: A sporangiospore that is motile, having flagella." ; oboInOwl:hasDbXref "FAO:0000039" ; a owl:Class ; rdfs:label "obsolete zoospore" ; owl:deprecated true . obo:CL_0000621 obo:IAO_0000115 "A myoblast that is committed to a myotube-specific program of differentiation but not yet fused. It undergoes very limited additional proliferation. After fusion, it will take on a muscle identity specified by a `muscle founder cell` (CL:0008006)." ; a owl:Class ; rdfs:label "fusion competent myoblast" ; rdfs:subClassOf obo:CL_0008018 . obo:CL_0000622 obo:IAO_0000115 "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." ; terms:description """Acinar cells are specialized exocrine gland cells that secrete specific enzymes and fluids to aid in digestion. Found primarily in the pancreas and salivary glands, the term acinar is derived from the Latin word 'acinus' which means 'grape'; this is because acinar cells are arranged in a grape-like cluster around small ducts, formulating an acinus structure. In the salivary glands, acinar cells secrete digestive enzymes as well as other substances such as mucus and water. These secretions service the initial stages of the digestive process, preparing the consumed food for onward digestion in the stomach and intestines by lubricating and partially breaking it down. In the pancreas, acinar cells are responsible for synthesizing and secreting a significant amount of digestive enzymes, such as trypsin, chymotrypsin, and amylase. These enzymes are stored in zymogen granules inside the acinar cells until they are dispatched into the small intestine. Once within the small intestine, they break down proteins, carbohydrates, and fats into substances that can be absorbed. This is vital to the effective and efficient digestion and absorption of nutrients from the food we consume. Acinar cells have high protein synthesis rates and are susceptible to accumulation of misfolded proteins; the subsequential induction of ER stress is thought to be involved in the development of pancreatitis, a serious inflammatory disease of the exocrine pancreas. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:83625", "MESH:D061354", "ZFA:0009277" ; oboInOwl:hasExactSynonym "acinic cell", "acinous cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "acinar cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000622" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000154, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009842 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 obo:CL_0000154 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009842 ] ) ] . obo:CL_0000623 obo:IAO_0000115 "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "large granular lymphocyte", "null cell" ; oboInOwl:hasDbXref "BTO:0000914", "BTO:0004716", "CALOHA:TS-0664", "FMA:63147", "FMA:83601", "MESH:D007694", "VHOG:0001697", "ZFA:0009278" ; oboInOwl:hasExactSynonym "NK cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "natural killer cell" ; rdfs:subClassOf obo:CL_0001067, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000825 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002228 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050776 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001067 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050776 ] ) ] . obo:CL_0000624 obo:IAO_0000115 "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "CD4-positive, alpha-beta T lymphocyte", "CD4-positive, alpha-beta T-cell", "CD4-positive, alpha-beta T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "CD4-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000791, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] ; owl:disjointWith obo:CL_0000625 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid3167 ] . obo:CL_0000625 obo:IAO_0000115 "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "CD8-positive, alpha-beta T lymphocyte", "CD8-positive, alpha-beta T-cell", "CD8-positive, alpha-beta T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "CD8-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000791, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000025402 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000791 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000025402 ] ) ] . obo:CL_0000626 obo:IAO_0000115 "A granule cell that has a soma located in an olfactory bulb granule cell layer. An olfactory granule cell is an interneuron that lacks an axon, makes reciprocal dendro-dendritic synapses with mitral cells and tufted cells and is involved in the fine spatio-temporal tuning of the responses of these principal olfactory bulb neurons to odors." ; oboInOwl:hasDbXref "ZFA:0001694" ; oboInOwl:hasExactSynonym "olfactory bulb granule cell" ; a owl:Class ; rdfs:comment "Granule cells are the most abundant neuronal population in the olfactory bulb and are continuously renewed throughout life." ; rdfs:label "olfactory granule cell" ; rdfs:subClassOf obo:CL_0000120, obo:CL_1001434, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005378 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002103 ; owl:someValuesFrom obo:CL_1001502 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002103 ; owl:someValuesFrom obo:CL_1001503 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_1001502 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_1001503 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002428 ; owl:someValuesFrom obo:GO_0007608 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000120 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005378 ] ) ] ; skos:prefLabel "olfactory granule cell" . obo:CL_0000627 obo:IAO_0000115 "OBSOLETE. A cell involved in transporting nutrients, minerals, water, gases and other chemicals between cells for a variety of purposes including conveying nutrition to other tissues, removing waste products from the tissues, conveying gases for respiration, distributing heat and repelling invasion of foreign substances." ; obo:IAO_0000233 ; a owl:Class ; rdfs:comment "Unsustainable functional grouping term of dubious utility." ; rdfs:label "obsolete transporting cell" ; owl:deprecated true . obo:CL_0000628 obo:IAO_0000115 "A cell that can perform photosynthesis, in which carbohydrates are synthesized from carbon dioxide and water, using light as the energy source." ; a owl:Class ; rdfs:comment "see PMID:21177950, The making of a photosynthetic animal." ; rdfs:label "photosynthetic cell" ; rdfs:subClassOf obo:CL_0000000, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0015979 ] . obo:CL_0000629 obo:IAO_0000115 "A cell that is specialized to store a particular substance(s), which is(are) later released from the store for a particular purpose." ; a owl:Class ; rdfs:label "storage cell" ; rdfs:subClassOf obo:CL_0000325 . obo:CL_0000630 obo:IAO_0000115 "A cell whose primary function is to support other cell types." ; oboInOwl:hasDbXref "BTO:0002315", "ZFA:0009387" ; oboInOwl:hasExactSynonym "supportive cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "supporting cell" ; rdfs:subClassOf obo:CL_0000000 ; skos:prefLabel "supporting cell" . obo:CL_0000631 obo:IAO_0000115 "Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen." ; a owl:Class ; rdfs:label "labyrinth supporting cell" ; rdfs:subClassOf obo:CL_0000630 . obo:CL_0000632 obo:IAO_0000115 "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0002741", "CALOHA:TS-0452", "FMA:67763", "ZFA:0009279" ; oboInOwl:hasExactSynonym "Ito cell", "hepatic perisinusoidal cell", "perisinusoidal cell" ; oboInOwl:hasRelatedSynonym "fat-storing cell", "lipocyte", "vitamin A-storing cells" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen." ; rdfs:label "hepatic stellate cell" ; rdfs:subClassOf obo:CL_0000057, obo:CL_0000327, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000007939 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002320 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000007939 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" . obo:CL_0000633 obo:IAO_0000115 "A tall supporting cell that is arranged in rows adjacent to the last row of outer phalangeal cells. This cell type constitutes the outer border of the organ of Corti." ; oboInOwl:hasDbXref "FMA:79799" ; oboInOwl:hasExactSynonym "Hensen's cell", "cell of Hensen", "external limiting cell of organ of Corti" ; a owl:Class ; rdfs:label "Hensen cell" ; rdfs:subClassOf obo:CL_0002490 . obo:CL_0000634 obo:IAO_0000115 "A cuboidal cell which along with Boettcher's cells form the floor of the external spiral sulcus, external to the organ of Corti." ; oboInOwl:hasDbXref "FMA:79802" ; oboInOwl:hasExactSynonym "cell of Claudius" ; oboInOwl:hasRelatedSynonym "external supporting cell of Claudius" ; a owl:Class ; rdfs:label "Claudius cell" ; rdfs:subClassOf obo:CL_0002315 . obo:CL_0000635 obo:IAO_0000115 "The outer phalangeal cells of the organ of Corti. This cell holds the base of the hair cell in a cup-shaped depression." ; oboInOwl:hasDbXref "FMA:75725" ; oboInOwl:hasExactSynonym "Deiters cell", "outer phalangeal cell" ; a owl:Class ; rdfs:label "Deiter's cell" ; rdfs:subClassOf obo:CL_0002165 . obo:CL_0000636 obo:IAO_0000115 "Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0003064", "ZFA:0009280" ; oboInOwl:hasExactSynonym "Muller cell", "Muller glia", "Müller cell" ; oboInOwl:inSubset cl:cellxgene_subset, cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "Mueller cell" ; rdfs:subClassOf obo:CL_0000681, obo:CL_0009004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] . obo:CL_0000637 obo:IAO_0000115 "A cell that stains readily in the anterior pituitary gland." ; oboInOwl:hasDbXref "FMA:83089" ; a owl:Class ; rdfs:label "chromophil cell of anterior pituitary gland" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000166, obo:CL_0000167, obo:CL_0012001, obo:CL_2000004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002196 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002196 ] ) ] ; skos:prefLabel "chromophil cell of anterior pituitary gland" . obo:CL_0000638 obo:IAO_0000115 "An acidophilic chromophil cell that of the anterior pituitary gland." ; oboInOwl:hasDbXref "FMA:83093" ; oboInOwl:hasExactSynonym "acidophil cell of pars anterior of adenohypophysis", "acidophil of pars anterior of adenohypophysis", "acidophil of pars distalis of adenohypophysis", "pituitary alpha cell" ; a owl:Class ; rdfs:label "acidophil cell of pars distalis of adenohypophysis" ; rdfs:subClassOf obo:CL_0000637, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006964 ] ; skos:prefLabel "acidophil cell of pars distalis of adenohypophysis" . obo:CL_0000639 obo:IAO_0000115 "A basophilic chromophil cell that of the anterior pituitary gland." ; oboInOwl:hasDbXref "FMA:83094" ; oboInOwl:hasExactSynonym "basophil cell of anterior lobe of hypophysis" ; oboInOwl:hasRelatedSynonym "beta cell", "pituitary beta cell" ; a owl:Class ; rdfs:label "basophil cell of pars distalis of adenohypophysis" ; rdfs:subClassOf obo:CL_0000637 . obo:CL_0000640 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000467 ; a owl:Class ; owl:deprecated true . obo:CL_0000641 obo:IAO_0000115 "A cell that is resistant to stains." ; oboInOwl:hasDbXref "FMA:83626" ; oboInOwl:hasExactSynonym "chromophobic cell" ; a owl:Class ; rdfs:label "chromophobe cell" ; rdfs:subClassOf obo:CL_0000163 . obo:CL_0000642 obo:IAO_0000115 "An agranular supporting cell of the anterior pituitary (adenohypophysis) that is characterized by a star-like morphology and ability to form follicles. Folliculostellate cells communicate with each other and with endocrine cells via gap junctions." ; oboInOwl:hasDbXref "ZFA:0009281" ; oboInOwl:hasExactSynonym "folliculo-stellate cell", "pituitary folliculostellate cell" ; oboInOwl:hasRelatedSynonym "FS cell", "FSC", "Sox2-positive stem cell" ; a owl:Class ; rdfs:comment "Folliculostellate cells are a heterogeneous group of cells rather than a single cell type, with different morphology and gene expression profiles. Due to this heterogeneity, it is unclear if different properties that have been attributed to folliculostellate cells (pluripotent, proliferative, phagocytic) are common in all folliculostellate cells or limited to particular subsets." ; rdfs:label "folliculostellate cell" ; rdfs:subClassOf obo:CL_0000630, obo:CL_2000004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002196 ] ; skos:prefLabel "folliculostellate cell" . obo:CL_0000643 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002085 ; a owl:Class ; owl:deprecated true . obo:CL_0000644 obo:IAO_0000115 "Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:54559", "ZFA:0009282" ; oboInOwl:hasExactSynonym "Bergmann astrocyte", "Bergmann glial cell of cerebellum" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "Bergmann glial cell" ; rdfs:subClassOf obo:CL_0002603, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002979 ] ; foaf:depiction . obo:CL_0000645 obo:IAO_0000115 "A glial cell of astrocytic lineage with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment." ; oboInOwl:hasDbXref "BTO:0003793", "FMA:83503" ; a owl:Class ; rdfs:label "pituicyte" ; rdfs:subClassOf obo:CL_0012000, obo:CL_2000004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002198 ] . obo:CL_0000646 obo:IAO_0000115 "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000939", "FMA:62516" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "basal cell" ; rdfs:subClassOf obo:CL_0000036 . obo:CL_0000647 obo:IAO_0000115 "A phagocytic syncytial cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes." ; oboInOwl:hasDbXref "BTO:0003107", "FMA:83035", "MESH:D015726" ; oboInOwl:hasExactSynonym "Langerhans giant cell", "foreign body giant cell", "macrophage polykaryon", "multinucleate giant cell", "syncytial giant cell" ; oboInOwl:hasRelatedSynonym "MGC" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:comment "Role or process: Chronic infection, granulomatous inflammation. Consider also megakaryocyte (CL:0000556) as sometimes multinucleated giant cell is used to refer to this." ; rdfs:label "multinucleated giant cell" ; rdfs:subClassOf obo:CL_0000766, obo:CL_4052002, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0002432 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0002544 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000235 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000766 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0002432 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0002544 ] ) ] . obo:CL_0000648 obo:IAO_0000115 "A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "juxtaglomerular cell" ; oboInOwl:hasDbXref "FMA:84138", "ZFA:0005238" ; oboInOwl:hasExactSynonym "JG cell", "renin secreting cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney granular cell" ; rdfs:subClassOf obo:CL_0000154, obo:CL_0000192, obo:CL_1000618, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002001 ] ) ] . obo:CL_0000649 obo:IAO_0000115 "A keratinocyte found within the stratum spinosum (prickle cell layer) of the epidermis, distinguished by numerous intercellular desmosomes, which give it a “prickly” or spiny appearance. Positioned above the mitotically active basal layer and beneath the granular layer, it contributes to the skin’s mechanical strength and barrier function, preventing water loss and pathogen entry. This cell expresses differentiation-specific keratins K1 and K10 in mice, unlike basal cells that express K5 and K14, and lacks the keratohyalin granules found in granular cells, marking its intermediate stage of epidermal differentiation." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:69059" ; oboInOwl:hasExactSynonym "prickle cell of epidermis", "spinous keratinocytes of epidermis" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "spinous cell of epidermis" ; rdfs:subClassOf obo:CL_4052060, obo:CL_4052061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002026 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4052060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002026 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-epidermal-ridge/v1.2/assets/2d-ftu-skin-epidermal-ridge.png" . obo:CL_0000650 obo:IAO_0000115 "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries." ; oboInOwl:hasDbXref "BTO:0000853", "CALOHA:TS-0617", "FMA:70972", "MESH:D050527", "ZFA:0009283" ; oboInOwl:hasExactSynonym "kidney mesangial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Do all of these cells really develop from some mesenchymal stem cell?" ; rdfs:label "mesangial cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000669, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000134 ] . obo:CL_0000651 obo:IAO_0000115 "OBSOLETE. A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands" ; obo:IAO_0100001 obo:CL_0002181 ; oboInOwl:hasBroadSynonym "neck cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "duplicate term" ; rdfs:label "obsolete mucous neck cell" ; owl:deprecated true . obo:CL_0000652 obo:IAO_0000115 "This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation." ; oboInOwl:hasDbXref "BTO:0001068", "FMA:83417", "ZFA:0009284" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "pinealocyte" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000163, obo:CL_0000710, obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001905 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030187 ] ; skos:prefLabel "pinealocyte" . obo:CL_0000653 obo:IAO_0000115 "A specialized kidney epithelial cell, contained within a glomerulus, that contains \"feet\" that interdigitate with the \"feet\" of other podocytes." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Podocytes are highly specialized, terminally differentiated glomerular visceral epithelial cells that wrap around the capillaries in the kidneys. They play an essential role in kidney function, particularly in the filtration selectivity of the glomerulus. Each podocyte is characterized by a unique architecture with a large cell body, ‘major processes’ extending outwardly from the cell body and ‘foot processes’, also known as pedicels, which surround. the glomerular capillary loops Podocytes represent the last barrier of the glomerular filtration membrane in the kidney. This barrier prevents the leakage of plasma proteins from the blood into the urine, hence maintaining protein homeostasis in the body. The foot processes of the podocytes interdigitate with those from neighboring cells. The cell-cell junctions between the foot processes, the slit-diaphragms, are thought to create a molecular sensor of renal filtration that prevents the passage of macromolecules while allowing water and small solutes to pass. Podocytes also contribute to the glomerular basement membrane by secreting collagen and maintain glomerular endothelial cell fenestration by secreting VEGFA. They have been shown to play a role in inducing cytoskeletal regulation, cell adhesion, and inflammatory response, consistent with their essential function in the kidney. The importance of podocytes is further emphasized by the effects of their damage or loss. Abnormalities in podocytes often result in severe kidney diseases (podocytopathies), including focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD). Injury to the podocytes can result in \"effacement\" or flattening of foot processes, leading to increased permeability of the filtration barrier and proteinuria (an excess of serum protein in urine) which is a common symptom of kidney diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasBroadSynonym "epithelial cell of visceral layer of glomerular capsule" ; oboInOwl:hasDbXref "BTO:0002295", "FMA:70967", "ZFA:0009285" ; oboInOwl:hasExactSynonym "glomerular podocyte", "glomerular visceral epithelial cell", "kidney podocyte", "renal podocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "podocyte" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000653", "https://github.com/obophenotype/cell-ontology/issues/1460" ; rdfs:subClassOf obo:CL_0002522, obo:CL_1000450, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005751 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005751 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" . obo:CL_0000654 obo:IAO_0000115 "A primary oocyte is an oocyte that has not completed female meosis I." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000512", "FMA:18645" ; oboInOwl:hasRelatedSynonym "primary oogonium" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "primary oocyte" ; rdfs:subClassOf obo:CL_0000023, [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0051321 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000024 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000023 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0051321 ] ) ] . obo:CL_0000655 obo:IAO_0000115 "A secondary oocyte is an oocyte that has not completed meiosis II." ; oboInOwl:hasDbXref "BTO:0003094", "FMA:18646" ; oboInOwl:hasRelatedSynonym "primary oogonium" ; a owl:Class ; rdfs:label "secondary oocyte" ; rdfs:subClassOf obo:CL_0000023, [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0007147 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000654 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000023 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0007147 ] ) ] . obo:CL_0000656 obo:IAO_0000115 "A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes." ; oboInOwl:hasDbXref "BTO:0001115", "CALOHA:TS-2194", "FMA:72292" ; a owl:Class ; rdfs:label "primary spermatocyte" ; rdfs:subClassOf obo:CL_0000017, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001394 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007140 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000017 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001394 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007140 ] ) ] . obo:CL_0000657 obo:IAO_0000115 "One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids." ; oboInOwl:hasDbXref "BTO:0000709", "CALOHA:TS-2195", "FBbt:00004941", "FMA:72293" ; a owl:Class ; rdfs:label "secondary spermatocyte" ; rdfs:subClassOf obo:CL_0000017, obo:CL_0000255, obo:CL_0000413, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000656 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007142 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000017 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001375 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007142 ] ) ] . obo:CL_0000658 obo:IAO_0000115 "An epithelial cell that secretes cuticle." ; a owl:Class ; rdfs:label "cuticle secreting cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0000327 . obo:CL_0000659 obo:IAO_0000115 "An extracellular matrix secreting cell that secretes eggshell." ; a owl:Class ; rdfs:label "eggshell secreting cell" ; rdfs:subClassOf obo:CL_0000327, obo:CL_0000500 . obo:CL_0000660 obo:IAO_0000115 "An extracellular matrix secreting cell that secretes glycocalyx." ; a owl:Class ; rdfs:label "glycocalyx secreting cell" ; rdfs:subClassOf obo:CL_0000327 . obo:CL_0000661 a owl:Class ; rdfs:label "distal tip cell (sensu Nematoda)" ; rdfs:subClassOf obo:CL_0000422 . obo:CL_0000662 a owl:Class ; rdfs:label "neuroglioblast (sensu Nematoda)" ; rdfs:subClassOf obo:CL_0000468 . obo:CL_0000663 obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_1000147 ; a owl:Class ; rdfs:label "obsolete valve cell" ; owl:deprecated true . obo:CL_0000664 obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_1000147 ; a owl:Class ; rdfs:label "obsolete closable valve cell" ; owl:deprecated true . obo:CL_0000665 obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_1000147 ; a owl:Class ; rdfs:label "obsolete permanently open valve cell" ; owl:deprecated true . obo:CL_0000666 obo:IAO_0000115 "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues." ; terms:description """Fenestrated cells are specialized epithelial cells that are characterized by a distinctive structural feature, fenestrations or tiny pores, which allow an exchange of substances such as fluids, nutrients, and waste between blood vessels and the surrounding tissue environments. These cells are present in various types of epithelial tissues in the human body, including the intestinal tract, endocrine glands, and certain parts of the renal system. There are multiple types of endothelial cell fenestrations. The most common type is found in systemic capillaries of the endocrine tissue (e.g., pancreatic islets), gastrointestinal mucosa, and renal peritubular capillaries. Here, the fenestrated cells have fenestrations in their peripheral cytoplasm with a unique thin and permeable diaphragm that provides a high degree of selectivity, blocking the passage of larger molecules while allowing the free movement of smaller ones. In contrast, other types of fenestrations, such as the discontinuous epithelium of the liver sinusoidal endothelial cells, do not have diaphragms. Characteristically, fenestrated cells play a vital role in the filtering process of body systems. They are a key part of the glomeruli in the kidneys where blood is filtered under high pressure. The fenestrations present in the endothelial cells lining the capillaries of the glomerulus allow the free passage of water and small solute molecules towards the Bowman's capsule, leaving behind larger proteins and cells in the blood, thereby aiding in the filtration and waste removal process. In the endocrine system, fenestrated cells in glandular capillaries allow the prompt release of hormones into the bloodstream. These cells have tightly clustered fenestrations which increase the surface area available for passive diffusion, improving the efficiency of hormone secretion. In villi of the small intestine, these cells increase absorption efficiency, permitting the exchange of water, electrolytes, and nutrients. Overall, fenestrated cells contribute immensely to important physiological processes of filtration, absorption, and secretion, primarily connecting our body's circulation system with the surrounding tissues and organs. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "ZFA:0009286" ; oboInOwl:hasExactSynonym "window cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "fenestrated endothelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000666" ; rdfs:subClassOf obo:CL_0000115, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002064 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002064 ] ) ] . obo:CL_0000667 obo:IAO_0000115 "An extracellular matrix secreting cell that secretes collagen." ; oboInOwl:hasDbXref "ZFA:0009287" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "collagen secreting cell" ; rdfs:subClassOf obo:CL_0000327 ; skos:prefLabel "collagen secreting cell" . obo:CL_0000668 obo:IAO_0000115 "OBSOLETE: The cell characteristic of an organ, as distinguished from associated connective or supporting tissues." ; oboInOwl:hasDbXref "BTO:0002174", "FMA:84638" ; a owl:Class ; rdfs:comment "OBSOLETE: Term was made obsolete to avoid confusion with plant parenchymal cell. Cell type has a similar but slightly different meaning in botany (plants): see PO:0000074." ; rdfs:label "obsolete parenchymal cell" ; owl:deprecated true . obo:CL_0000669 obo:IAO_0000115 "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0002441", "FMA:63174", "ZFA:0009112" ; oboInOwl:hasExactSynonym "ARC", "adventitial reticular cell", "cell of Rouget", "pericyte cell", "pericyte of Rouget" ; oboInOwl:hasRelatedSynonym "adventitial cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A." ; rdfs:label "pericyte" ; rdfs:subClassOf obo:CL_0000183, obo:CL_0000630, obo:CL_0002320, obo:CL_0008034 . obo:CL_0000670 obo:IAO_0000115 "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." ; oboInOwl:hasDbXref "FMA:70567", "ZFA:0009288" ; oboInOwl:hasExactSynonym "gonocyte", "primitive germ cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "primordial germ cell" ; rdfs:subClassOf obo:CL_0000039, obo:CL_0000219, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000039 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048870 ] ) ] . obo:CL_0000671 obo:IAO_0000115 "A follicle cell that migrates from the dorso-anterior part of the oocyte associated follicular epithelium, in between the nurse cells and the oocyte, and participates in the formation of the operculum." ; oboInOwl:hasDbXref "FBbt:00004906" ; oboInOwl:hasExactSynonym "centripetal follicle cell" ; a owl:Class ; rdfs:label "centripetally migrating follicle cell" ; rdfs:subClassOf obo:CL_0000477 . obo:CL_0000672 obo:IAO_0000115 "Obsolete. Use PO:0000290 from Plant Ontology instead. A water conducting cell, tracheid or vessel member." ; obo:IAO_0100001 obo:PO_0000290 ; a owl:Class ; rdfs:label "obsolete tracheary element" ; owl:deprecated true . obo:CL_0000673 obo:IAO_0000115 "An intrinsic neuron of the mushroom body of arthropods and annelids. They have tightly packed, cytoplasm-poor cell bodies." ; oboInOwl:hasBroadSynonym "mushroom body intrinsic neuron" ; oboInOwl:hasDbXref "FBbt:00003686" ; oboInOwl:hasRelatedSynonym "globuli cell" ; a owl:Class ; rdfs:label "Kenyon cell" ; rdfs:subClassOf obo:CL_0000028, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001058 ] . obo:CL_0000674 obo:IAO_0000115 "A follicle cell that is part of the stalk connecting adjacent egg chambers." ; oboInOwl:hasDbXref "FBbt:00004910" ; oboInOwl:hasExactSynonym "stalk cell", "stalk follicle cell" ; a owl:Class ; rdfs:label "interfollicle cell" ; rdfs:subClassOf obo:CL_0000477 . obo:CL_0000675 obo:IAO_0000115 "A mature sexual reproductive cell of the female germline." ; a owl:Class ; rdfs:label "female gamete" ; rdfs:subClassOf obo:CL_0000021, obo:CL_0000300 . obo:CL_0000676 oboInOwl:hasDbXref "BTO:0001033" ; a owl:Class ; rdfs:label "cap cell" ; rdfs:subClassOf obo:CL_0000378 . obo:CL_0000677 obo:IAO_0000115 "Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules." ; oboInOwl:hasDbXref "ZFA:0009289" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "gut absorptive cell" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001277 ] . obo:CL_0000678 obo:IAO_0000115 "A neuron with soma location in the central nervous system that project its axon to the contralateral side of a central nervous system. This neuron can have its soma in the spinal cord, in the hemisphere of the brain, in the retina or in the ventral nerve cord of invertebrates." ; a owl:Class ; rdfs:comment "Historically, commissural neurons, particularly in the spinal cord, have been used as a model to understand axon guidance during development." ; rdfs:label "commissural neuron" ; rdfs:subClassOf obo:CL_2000029 . obo:CL_0000679 obo:IAO_0000115 "A neuron that is capable of some neurotansmission by glutamate secretion." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FBbt:00100291", "WBbt:0006829", "ZFA:0009290" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "glutamatergic neuron" ; rdfs:subClassOf obo:CL_0000151, obo:CL_0000540, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061535 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061535 ] ) ] ; skos:prefLabel "glutamatergic neuron" . obo:CL_0000680 obo:IAO_0000115 "A non-terminally differentiated cell that is capable of developing into a muscle cell." ; oboInOwl:hasDbXref "ZFA:0009291" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "muscle precursor cell" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000222 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000187 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011115 [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000187 ] ) ] ; skos:prefLabel "muscle precursor cell" . obo:CL_0000681 obo:IAO_0000115 "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." ; oboInOwl:hasDbXref "ZFA:0009292" ; oboInOwl:hasNarrowSynonym "forebrain radial glial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment """Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of radial glial cells acting as neural progenitors throughout life.""" ; rdfs:label "radial glial cell" ; rdfs:subClassOf obo:CL_0000125, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000710 ] ; skos:prefLabel "radial glial cell" . obo:CL_0000682 obo:IAO_0000115 "An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """M cells, or microfold cells, of the gut are specialized epithelial cells found in the lining of the gut, specifically in the follicle-associated epithelium of mucosa-associated lymphoid tissue, where they function as sentries against toxins and pathogens. M cells are characterized by apical microfolds (hence their alternate name) which express unique adhesion molecules that enable them to sample the luminal macromolecules. Other morphological features that distinguish M cells from other intestinal mucosal cells include sparse microvilli and a reduced thickness of the glycocalyx, which permits adhesion while not hindering the transport of molecules. They also have unique intraepithelial invaginations on the basolateral side which are filled with macrophages and other immune cells that can process the engulfed macromolecules quickly. These morphological characteristics enable M cells to serve a dual role in immune responses. They initiate the immune response by transporting antigens (such as toxic or pathogenic substances) across the epithelial layer to lymphocytes and antigen-presenting cells in the underlying lymphoid tissue. This specialized transport process is called 'transcytosis.' They also have specialized molecules like glycoprotein-2 for bacterial uptake. Simultaneously, M cells help maintain immune tolerance to food antigens and commensal bacteria, preventing unnecessary reactions to non-pathogenic substances and hypersensitivity conditions. While these functions are crucial for well-being, M cell dysfunction can lead to serious conditions like Crohn's disease and other inflammatory bowel diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasBroadSynonym "M cell"@en ; oboInOwl:hasDbXref "BTO:0003600", "FMA:62929", "ZFA:0009293" ; oboInOwl:hasExactSynonym "M-cell", "microfold cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Should double check and see if M cells are particular to a specific region." ; rdfs:label "M cell of gut" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000682" ; rdfs:subClassOf obo:CL_0002563, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004693 ] . obo:CL_0000683 obo:IAO_0000115 "A cell that transports hormones from neurosecretory cells. This nerve cell is characterized by bipolar shape and endfeet that contact a basal lamina around blood vessels, and/or the pia mater or vitreous body of the eye and additionally contact the ventricular surface or sub-retinal space." ; oboInOwl:hasDbXref "MESH:D063928", "ZFA:0009294" ; oboInOwl:hasExactSynonym "ependymal astrocyte" ; a owl:Class ; rdfs:label "ependymoglial cell" ; rdfs:subClassOf obo:CL_0000065 . obo:CL_0000684 a owl:Class ; rdfs:label "littoral cell of liver" ; rdfs:subClassOf obo:CL_0000077, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] . obo:CL_0000685 obo:IAO_0000115 "Obsolete. Use PO:0004010 from Plant Ontology instead. A cell synthesizing protoplasm and producing new cells by division and with only a primary cell wall." ; obo:IAO_0100001 obo:PO_0004010 ; a owl:Class ; rdfs:label "obsolete meristematic cell" ; owl:deprecated true . obo:CL_0000686 obo:IAO_0000115 "A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid." ; oboInOwl:hasDbXref "ZFA:0009295" ; a owl:Class ; rdfs:label "cerebrospinal fluid secreting cell" ; rdfs:subClassOf obo:CL_0000710, obo:CL_1100001, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0033326 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0033326 ] ) ] . obo:CL_0000687 oboInOwl:hasDbXref "FBbt:00004213" ; oboInOwl:hasExactSynonym "R1 cell" ; a owl:Class ; rdfs:label "R1 photoreceptor cell" ; rdfs:subClassOf obo:CL_0000488, obo:CL_2000019, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000971 ] . obo:CL_0000688 obo:IAO_0000115 "A fibroblast-like cell that provides support at neuromuscular junctions in vertebrates and are localized outside the synaptic basal lamina." ; oboInOwl:hasDbXref "ZFA:0009296" ; a owl:Class ; rdfs:label "perijunctional fibroblast" ; rdfs:subClassOf obo:CL_0000057, obo:CL_0000630 . obo:CL_0000689 obo:IAO_0000115 "A cell with both myofibrils and secretory granules." ; a owl:Class ; rdfs:label "myoendocrine cell" ; rdfs:subClassOf obo:CL_0000163 . obo:CL_0000690 oboInOwl:hasDbXref "FBbt:00004215" ; oboInOwl:hasExactSynonym "R2 cell" ; a owl:Class ; rdfs:label "R2 photoreceptor cell" ; rdfs:subClassOf obo:CL_0000488, obo:CL_2000019, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000971 ] . obo:CL_0000691 obo:IAO_0000115 "Any interneuron that has characteristic some stellate morphology." ; oboInOwl:hasDbXref "ZFA:0009297" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "stellate interneuron" ; rdfs:subClassOf obo:CL_0000099, obo:CL_0000122 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070010 ] ) ] . obo:CL_0000692 obo:IAO_0000115 "A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse." ; oboInOwl:hasBroadSynonym "Schwann cell" ; oboInOwl:hasDbXref "ZFA:0009298" ; oboInOwl:hasExactSynonym "perisynaptic Schwann cell", "teloglia" ; oboInOwl:hasRelatedSynonym "tSC" ; a owl:Class ; rdfs:label "terminal Schwann cell" ; rdfs:subClassOf obo:CL_0000630, obo:CL_0002376 . obo:CL_0000693 obo:IAO_0000115 "An interneuron that has spider-like appearance with a small round soma, a large number (7-10) of short, smooth, or slightly beaded primary dendrites that give rise to only a few secondary branches, and a branched axon that establishes a dense axonal mesh with thin shafts." ; oboInOwl:hasDbXref "ZFA:0009299" ; oboInOwl:hasExactSynonym "NGF cell", "neuroglioform cell", "spiderweb cell" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "neurogliaform cell" ; rdfs:subClassOf obo:CL_0000099, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070001 ] ) ] . obo:CL_0000694 oboInOwl:hasDbXref "FBbt:00004217" ; oboInOwl:hasExactSynonym "R3 cell" ; a owl:Class ; rdfs:label "R3 photoreceptor cell" ; rdfs:subClassOf obo:CL_0000488, obo:CL_2000019, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000971 ] . obo:CL_0000695 obo:IAO_0000115 "A type of transient, early-born glutamatergic neuron located primarily in the marginal zone (future layer I) of the developing cerebral cortex and hippocampus in vertebrates. it is characterized by a bipolar morphology with an elongated soma, a single thick dendrite oriented toward the pial surface, and a long, thin axon that extends tangentially to form horizontal plexuses across the cortical surface. It is important for the multiple developmental processes including migration, dendritogenesis and synaptogenesis. It typically undergoes programmed cell death following cortical maturation with species- and region specific patterns of survival. In mice, it is predominantly observed in the hippocampal formation, particularly in the stratum lacunosum-moleculare and outer molecular layer of the dentate gyrus (van Bruggen et al., 2023). In contrast, in humans, a second morphologically distinct subpopulation emerges mid-gestation and persists postnatally, with surviving cells observed in the cortical sulci and the hippocampus." ; terms:contributor ; oboInOwl:hasDbXref "ZFA:0009300" ; oboInOwl:hasExactSynonym "CR cells", "Horizontal cells of Cajal" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "While previously called 'pioneer neurons' of the marginal zone, Cajal-Retzius cells are differentiated from pioneer neurons (which are Reln-negative) by their Reln-immunoreactivity." ; rdfs:label "Cajal-Retzius cell" ; rdfs:subClassOf obo:CL_0000679, obo:CL_0012001, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070006 ] . obo:CL_0000696 obo:IAO_0000115 "A cell that stores and secretes pancreatic polypeptide hormone." ; terms:description """PP cells, also known as pancreatic polypeptide cells (and previously called F cells or gamma cells), are enteroendocrine cells predominantly found in the islets of Langerhans in the head of the pancreas. They are one of the four main endocrine cell types present in the pancreatic islets, along with type A, B and D cells. PP cells are notable for their production of pancreatic polypeptide, an anorexigenic hormone that modulates food intake and energy homeostasis. By secreting pancreatic polypeptide, PP cells play a significant role in the management of both digestive and appetite regulation. Upon ingestion of food, there is a significant increase in the secretion of pancreatic polypeptide, which then reduces biliary secretion and helps slow down the movement of food through the digestive tract. This allows more time for digestion to take place and nutrients to be absorbed, promoting the efficient use of dietary intake. The pancreatic polypeptide further reduces appetite by interacting with the hypothalamus, the area of the brain responsible for control of hunger. Given their important role in digestion, malfunction or damage to PP cells can lead to a disturbance in the digestive process and contribute to some disease conditions. For example, an overproduction of pancreatic polypeptide can result in conditions such as pancreatic tumors and diabetes. Conversely, an under secretion might contribute to obesity due to impaired dietary control. Furthermore, PP cells may also play a role in the body's energy balance, suggesting their implication in conditions related to energy metabolism. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:62938", "FMA:83409" ; oboInOwl:hasExactSynonym "type F enteroendocrine cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "PP cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000696" ; rdfs:subClassOf obo:CL_0000164, obo:CL_0000167 . obo:CL_0000697 oboInOwl:hasDbXref "FBbt:00004219" ; oboInOwl:hasExactSynonym "R4 cell" ; a owl:Class ; rdfs:label "R4 photoreceptor cell" ; rdfs:subClassOf obo:CL_0000488, obo:CL_2000019, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000971 ] . obo:CL_0000698 a owl:Class ; rdfs:label "obsolete paraganglial cell" ; owl:deprecated true . obo:CL_0000699 obo:IAO_0000115 "A type of glomus or chief cell, is sensitive to hypoxia and produce catecholamines." ; a owl:Class ; rdfs:label "paraganglial type 1 cell" ; rdfs:subClassOf obo:CL_0000165 . obo:CL_0000700 obo:IAO_0000115 "A neuron that releases dopamine as a neurotransmitter." ; oboInOwl:hasDbXref "BTO:0004032", "FBbt:00005131", "FMA:84787", "MESH:D059290", "WBbt:0006746", "ZFA:0009301" ; oboInOwl:hasExactSynonym "dopaminergic cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "dopaminergic neuron" ; rdfs:subClassOf obo:CL_4033050, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061527 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061527 ] ) ] ; skos:prefLabel "dopaminergic neuron" . obo:CL_0000701 obo:IAO_0000115 "Supports paraganglial type 1 cell." ; a owl:Class ; rdfs:label "paraganglia type 2 cell" ; rdfs:subClassOf obo:CL_0000630 . obo:CL_0000702 oboInOwl:hasDbXref "FBbt:00004221" ; oboInOwl:hasExactSynonym "R5 cell" ; a owl:Class ; rdfs:label "R5 photoreceptor cell" ; rdfs:subClassOf obo:CL_0000488, obo:CL_2000019, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000971 ] . obo:CL_0000703 obo:IAO_0000115 "Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors." ; oboInOwl:hasDbXref "BTO:0002315", "ZFA:0009302" ; a owl:Class ; rdfs:label "sustentacular cell" ; rdfs:subClassOf obo:CL_0000630 . obo:CL_0000704 obo:IAO_0000115 "A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels." ; oboInOwl:hasDbXref "ZFA:0009303" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "endothelial tip cell" ; rdfs:subClassOf obo:CL_0000071 . obo:CL_0000705 oboInOwl:hasDbXref "FBbt:00004223" ; oboInOwl:hasExactSynonym "R6 cell" ; a owl:Class ; rdfs:label "R6 photoreceptor cell" ; rdfs:subClassOf obo:CL_0000488, obo:CL_2000019, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000971 ] . obo:CL_0000706 obo:IAO_0000115 "A specialized ependymal cell that is part of the choroid plexus epithelium, responsible for producing cerebrospinal fluid (CSF) by selectively filtering and modifying blood plasma components before secreting it into the brain and spinal cord. This cell is characterized by a brush border on its apical surface, which enhances the secretion of CSF." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:date "2023-08-04T08:48:30Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "choroid plexus cell" ; oboInOwl:hasDbXref "FMA:70549", "ZFA:0009304" ; oboInOwl:hasExactSynonym "epithelial cell of choroid plexus" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "A choroid plexus epithelial cell possesses non-motile 9+0 cilia. While these cilia can exhibit transient motility during development, they generally do not contribute significantly to the directional flow of cerebrospinal fluid (CSF). Instead, they are primarily involved in sensory functions." ; rdfs:label "choroid plexus epithelial cell" ; rdfs:subClassOf obo:CL_0000065, obo:CL_0000239, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003911 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0033326 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000065 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003911 ] ) ] . obo:CL_0000707 oboInOwl:hasDbXref "FBbt:00004225" ; oboInOwl:hasExactSynonym "R7 cell" ; a owl:Class ; rdfs:label "R7 photoreceptor cell" ; rdfs:subClassOf obo:CL_0000494, obo:CL_2000019, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000971 ] . obo:CL_0000708 obo:IAO_0000115 "Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus." ; oboInOwl:hasDbXref "ZFA:0009305" ; oboInOwl:hasRelatedSynonym "leptomemingeal cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "leptomeningeal cell" ; rdfs:subClassOf obo:CL_0000327, obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003210 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000327 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003210 ] ) ] . obo:CL_0000709 oboInOwl:hasDbXref "FBbt:00004227" ; oboInOwl:hasExactSynonym "R8 cell" ; a owl:Class ; rdfs:label "R8 photoreceptor cell" ; rdfs:subClassOf obo:CL_0000488, obo:CL_2000019, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000971 ] . obo:CL_0000710 obo:IAO_0000115 "Epithelial cells derived from neural plate and neural crest." ; oboInOwl:hasBroadSynonym "neuroepithelial cell" ; oboInOwl:hasDbXref "BTO:0004301", "FMA:70557" ; a owl:Class ; rdfs:comment "The term \"neuroepithelial cell\" is used to describe both this cell type and sensory epithelial cell (CL:0000098)." ; rdfs:label "neurecto-epithelial cell" ; rdfs:subClassOf obo:CL_0000075, obo:CL_0002077, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000133 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002077 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000133 ] ) ] ; skos:prefLabel "neurecto-epithelial cell" . obo:CL_0000711 obo:IAO_0000115 "Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0002236", "MESH:D054885" ; oboInOwl:hasExactSynonym "cumulus cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cumulus granulosa cell" ; rdfs:subClassOf obo:CL_0000154, obo:CL_0000501, obo:UBERON_0004120, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_4033084 ] . obo:CL_0000712 obo:IAO_0000115 "Any epidermal cell that is part of some stratum granulosum of epidermis." ; a owl:Class ; rdfs:label "stratum granulosum cell" ; rdfs:subClassOf obo:CL_0000362, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002069 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000362 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002069 ] ) ] . obo:CL_0000713 a owl:Class ; rdfs:label "corona radiata cell" ; rdfs:subClassOf obo:CL_0000711 . obo:CL_0000714 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000513 ; a owl:Class ; owl:deprecated true . obo:CL_0000715 obo:IAO_0000115 "A crystal cell that derives from the embryonic head mesoderm." ; oboInOwl:hasDbXref "FBbt:00001690" ; a owl:Class ; rdfs:label "embryonic crystal cell" ; rdfs:subClassOf obo:CL_0000392, obo:CL_0011008 . obo:CL_0000716 obo:IAO_0000115 "A crystal cell that derives from the larval lymph gland." ; a owl:Class ; rdfs:label "lymph gland crystal cell" ; rdfs:subClassOf obo:CL_0000392, obo:CL_0000735 . obo:CL_0000717 obo:IAO_0000115 "OBSOLETE. A subset of motor neurons that innervates intrafusal muscle fibers and has small diameter axons." ; obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0008037 ; a owl:Class ; rdfs:comment "Term merged into CL:0008037." ; rdfs:label "obsolete fusimotor neuron" ; owl:deprecated true . obo:CL_0000718 obo:IAO_0000115 "A cell of an ommatidium that secretes lens materials." ; oboInOwl:hasDbXref "FBbt:00004193" ; oboInOwl:hasExactSynonym "Semper cell" ; oboInOwl:hasRelatedSynonym "cone cell (sensu Endopterygota)" ; a owl:Class ; rdfs:comment "Not to be confused with the Semper cells of the Semper organ found in gastropods." ; rdfs:label "compound eye cone cell" ; rdfs:subClassOf obo:CL_0000306, obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000971 ] . obo:CL_0000719 a owl:Class ; rdfs:label "posterior cone cell (sensu Endopterygota)" ; rdfs:subClassOf obo:CL_0000718 . obo:CL_0000720 a owl:Class ; rdfs:label "anterior cone cell (sensu Endopterygota)" ; rdfs:subClassOf obo:CL_0000718 . obo:CL_0000721 a owl:Class ; rdfs:label "equatorial cone cell (sensu Endopterygota)" ; rdfs:subClassOf obo:CL_0000718 . obo:CL_0000722 a owl:Class ; rdfs:label "cystoblast" ; rdfs:subClassOf obo:CL_0000255, obo:CL_0000586, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_6656 ] . obo:CL_0000723 obo:IAO_0000115 "A stem cell that can give rise to cell types of the body other than those of the germ-line." ; oboInOwl:hasDbXref "CALOHA:TS-2086", "MESH:D053687", "ZFA:0009307" ; a owl:Class ; rdfs:label "somatic stem cell" ; rdfs:subClassOf obo:CL_0000034, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048103 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048103 ] ) ] ; skos:prefLabel "somatic stem cell" . obo:CL_0000724 obo:IAO_0000115 "A differentiated cell that functions as a site of nitrogen fixation under aerobic conditions." ; oboInOwl:hasDbXref "BTO:0000600" ; a owl:Class ; rdfs:label "heterocyst" ; rdfs:subClassOf obo:CL_0000520, obo:CL_0000725 . obo:CL_0000725 obo:IAO_0000115 "Any cell that is capable of some nitrogen fixation." ; a owl:Class ; rdfs:label "nitrogen fixing cell" ; rdfs:subClassOf obo:CL_0000000, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0009399 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0009399 ] ) ] . obo:CL_0000726 obo:IAO_0000115 "An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material." ; a owl:Class ; rdfs:comment "Considering obsoleting as sometimes used to refer to protozoans too. But reference indicates term was intended for fungus." ; rdfs:label "chlamydospore" ; rdfs:subClassOf obo:CL_0000605 . obo:CL_0000727 obo:IAO_0000233 ; a owl:Class ; rdfs:comment "Obsoleted as this level of precision is deemed unnecessary for CL. Consider using either the more general CL:0001658 or, if you need to refer to primary pigment cells specifically, a term from a taxon-specific ontology such as FBbt:00004231." ; rdfs:label "obsolete primary pigment cell" ; owl:deprecated true . obo:CL_0000728 obo:IAO_0000233 ; a owl:Class ; rdfs:comment "Obsoleted as this level of precision is deemed unnecessary for CL. Consider using either the more general CL:0001658 or, if you need to refer to secondary pigment cells specifically, a term from a taxon-specific ontology such as FBbt:00004232." ; rdfs:label "obsolete secondary pigment cell" ; owl:deprecated true . obo:CL_0000729 obo:IAO_0000233 ; a owl:Class ; rdfs:comment "Obsoleted as this level of precision is deemed unnecessary for CL. Consider using either the more general CL:0001658 or, if you need to refer to tertiary pigment cells specifically, a term from a taxon-specific ontology such as FBbt:00004233." ; rdfs:label "obsolete tertiary pigment cell" ; owl:deprecated true . obo:CL_0000730 obo:IAO_0000115 "A cell at the front of a migrating epithelial sheet." ; a owl:Class ; rdfs:label "leading edge cell" ; rdfs:subClassOf obo:CL_0000066 . obo:CL_0000731 obo:IAO_0000115 "A cell of a layer of transitional epithelium in the wall of the proximal urethra, bladder, ureter or renal pelvis, external to the lamina propria." ; terms:description """Urothelial cells are a unique type of epithelial cell found lining the urinary tract system. They form the urothelium, a specialized, multi-layered epithelium that lines major portions of the urinary tract, including the renal pelvis, ureters, bladder, and the proximal part of the urethra. The distinct characteristic of urothelial cells is their ability to stretch and contract depending on the volume of liquid they contain - a feature that facilitates the essential role they play in maintaining the functionality and integrity of the urinary system. The primary function of urothelial cells is to provide an impermeable barrier to urine, preventing the toxic components present in the urine from seeping back into the body's bloodstream. The urothelium consists of a superficial umbrella cell layer, 1–2 layers of intermediate cells, and a basal cell layer. The umbrella layer is composed of large, mostly binucleated cells that are covered in an asymmetrical unit membrane, the uroplakin plaques. These plaques function to seal the apical membrane of the bladder from the toxic and highly variable contents of urine. The lipid bilayer structure of uroplakin plaques has an exceptionally high concentration of uroplakins that contribute to the barrier function of the urothelium. Beyond their mechanical function, urothelial cells also play a role in sensing and signaling changes in the urinary system. They express a number of sensor molecules or respond to thermal, mechanical and chemical stimuli and can release chemical mediators. This allows them to act as sensory transducers because they detect changes in the filling state of the bladder and transmit this information to the nervous system. Moreover, these versatile cells contribute to the defense mechanism against urinary tract pathogens. They respond to bacterial infections by releasing chemical messengers, cytokines and chemokines, to attract immune cells, and also can engulf pathogens via endocytosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:84127", "ZFA:0009308" ; oboInOwl:hasNarrowSynonym "urinary tract transitional epithelial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "urothelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000731" ; rdfs:subClassOf obo:CL_0000244, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000365 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000244 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000365 ] ) ] . obo:CL_0000732 a owl:Class ; rdfs:label "amoeboid cell" ; rdfs:subClassOf obo:CL_0000219 . obo:CL_0000733 obo:IAO_0000115 "A plasmatocyte that derives from the larval lymph gland." ; a owl:Class ; rdfs:label "lymph gland plasmatocyte" ; rdfs:subClassOf obo:CL_0000394, obo:CL_0000735 . obo:CL_0000734 obo:IAO_0100001 obo:CL_0011009 ; a owl:Class ; rdfs:comment "Obsoleted as this is the same thing as 'embryonic plasmatocyte'." ; rdfs:label "obsolete embryonic gland plasmatocyte" ; owl:deprecated true . obo:CL_0000735 obo:IAO_0000115 "A hemocyte that derives from the larval lymph gland." ; oboInOwl:hasDbXref "FBbt:00005917" ; a owl:Class ; rdfs:label "lymph gland hemocyte" ; rdfs:subClassOf obo:CL_0000387 . obo:CL_0000736 obo:IAO_0100001 obo:CL_0011008 ; a owl:Class ; rdfs:comment "Obsoleted as this term probably resulted from a confusion. Hemocytes are either derived from the embryonic head mesoderm (\"embryonic hemocytes\") or from the larval lymph gland (\"lymph gland hemocytes\"), not from an \"embryonic gland\"." ; rdfs:label "obsolete embryonic gland hemocyte" ; owl:deprecated true . obo:CL_0000737 obo:IAO_0000115 "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." ; oboInOwl:hasDbXref "BTO:0002916", "CALOHA:TS-2157", "FMA:86936", "ZFA:0005784" ; a owl:Class ; rdfs:label "striated muscle cell" ; rdfs:subClassOf obo:CL_0000187, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001410 ] ; owl:disjointWith obo:CL_0008000 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001410 ] ) ] ; skos:prefLabel "striated muscle cell" . obo:CL_0000738 obo:IAO_0000115 "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000751", "CALOHA:TS-0549", "FMA:62852", "MESH:D007962", "NCIT:C12529", "ZFA:0009309" ; oboInOwl:hasExactSynonym "leucocyte", "white blood cell" ; oboInOwl:hasRelatedSynonym "immune cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "leukocyte" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000219, obo:CL_0000255, obo:CL_0000988, obo:CL_0002242, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002405 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_7742 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000037 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001667 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000988 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002505 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001667 ] ) ] . obo:CL_0000739 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000043 ; a owl:Class ; owl:deprecated true . obo:CL_0000740 obo:IAO_0000115 "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0001800", "FMA:67765", "MESH:D012165", "ZFA:0009310" ; oboInOwl:hasExactSynonym "gangliocyte", "ganglion cell of retina" ; oboInOwl:hasRelatedSynonym "RGC", "RGCs" ; oboInOwl:inSubset cl:cellxgene_subset, cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "retinal ganglion cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000540, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000966 ] ; skos:prefLabel "retinal ganglion cell" . obo:CL_0000741 obo:IAO_0000115 "A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord." ; oboInOwl:hasDbXref "ZFA:0009311" ; oboInOwl:hasExactSynonym "SACMN" ; a owl:Class ; rdfs:label "spinal accessory motor neuron" ; rdfs:subClassOf obo:CL_0008039 . obo:CL_0000742 obo:IAO_0000115 "A round chondrocyte that first differentiates in the late embryonic growth plate of bone." ; oboInOwl:hasDbXref "ZFA:0009312" ; a owl:Class ; rdfs:label "periarticular chondrocyte" ; rdfs:subClassOf obo:CL_1001607 . obo:CL_0000743 obo:IAO_0000115 "Chondrocyte that is terminally differentiated, produces type X collagen, is large in size, and often associated with the replacement of cartilage by bone (endochondral ossification)." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0009313" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "is hypertrophic pathological or normal? and can it be described using a pato term?" ; rdfs:label "hypertrophic chondrocyte" ; rdfs:subClassOf obo:CL_0000138 . obo:CL_0000744 obo:IAO_0000115 "A columnar chondrocyte that differentiates in the late embryonic growth plate of bone. Columnar chondrocytes vigorously proliferate and form columns in the growth plate." ; oboInOwl:hasDbXref "ZFA:0009314" ; a owl:Class ; rdfs:label "columnar chondrocyte" ; rdfs:subClassOf obo:CL_0000138 . obo:CL_0000745 obo:IAO_0000115 "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0004120", "ZFA:0009315" ; oboInOwl:hasExactSynonym "horizontal cell" ; oboInOwl:hasRelatedSynonym "HC", "HCs" ; oboInOwl:inSubset cl:cellxgene_subset, cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "retina horizontal cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000099, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0003902 ] . obo:CL_0000746 obo:IAO_0000115 "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Cardiac muscle cells, also known as cardiomyocytes or cardiac myocytes, are specialized cells that form the heart tissue. These cells are elongated, branched, and contain a single centrally located nucleus. Their anatomy is composed primarily of densely packed myofibrils, which are protein structures that consist of sarcomeres - the fundamental units of muscle contraction. Cardiac muscle cells are united at their ends through specialized junctions known as intercalated discs, which allow the heart to contract in a unified, powerful and rhythmic way. Functionally, cardiac muscle cells are responsible for the heart's consistent pumping action that circulates blood throughout the body. Unlike most cells in the body, cardiac muscle cells spontaneously depolarize and generate action potentials without external stimulation. This unique trait stems from the presence of ion channels in the cells' membrane that allow a cyclic flow of ions across the membrane, which create the electrical impulses necessary for heart contraction. The spread of these electrical signals from one cardiac muscle cell to another - facilitated by the interconnected network made by the intercalated disks - results in a synchronized contraction of the heart muscle. Unlike skeletal muscle cells which can tire and need rest, cardiac muscle cells have to work ceaselessly throughout the entire lifespan, without the opportunity for rest, to ensure continuous circulation of blood. This is made possible through the high volume of mitochondria and a constant supply of oxygen from coronary circulation. In conclusion, cardiac muscle cells, through their unique structure and vital functionality, play a pivotal role in sustaining life by providing the means for blood to reach every cell in the body. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasBroadSynonym "cardiocyte" ; oboInOwl:hasDbXref "BTO:0001539", "CALOHA:TS-0115", "FMA:14067", "MESH:D032383", "ZFA:0009316" ; oboInOwl:hasExactSynonym "cardiac muscle fiber", "cardiac myocyte", "cardiomyocyte", "heart muscle cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction." ; rdfs:label "cardiac muscle cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000746" ; rdfs:subClassOf obo:CL_0000737, obo:CL_0002494, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002478 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0060047 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000513 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007100 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002478 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0060047 ] ) ] . obo:CL_0000747 obo:IAO_0000115 "A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance." ; oboInOwl:hasDbXref "ZFA:0009317" ; oboInOwl:hasRelatedSynonym "blue chromatophore" ; a owl:Class ; rdfs:label "cyanophore" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000147, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0005005 ] . obo:CL_0000748 obo:IAO_0000115 "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0009318" ; oboInOwl:hasRelatedSynonym "BC", "BCs", "BPs" ; oboInOwl:inSubset cl:cellxgene_subset, cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "retinal bipolar neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000679, obo:CL_0008028, obo:CL_0009004, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001791 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0061535 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0098976 ] ) ] ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001791 ] ) ] . obo:CL_0000749 obo:IAO_0000115 "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0009319" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "ON-bipolar cell" ; rdfs:subClassOf obo:CL_0000748 . obo:CL_0000750 obo:IAO_0000115 "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the outer half of the inner plexiform layer. These cells depolarize in response to light to dark transition." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0009320" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "OFF-bipolar cell" ; rdfs:subClassOf obo:CL_0000748 . obo:CL_0000751 obo:IAO_0000115 "A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells but not by cone photoreceptor cells. These neurons depolarize in response to light." ; obo:RO_0002175 obo:NCBITaxon_32443 ; oboInOwl:hasDbXref "FMA:67750", "ZFA:0009321" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "rod bipolar cell" ; rdfs:subClassOf obo:CL_0000749, [ a owl:Restriction ; owl:onProperty obo:RO_0002102 ; owl:someValuesFrom obo:UBERON_0008925 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002102 ; owl:someValuesFrom obo:UBERON_0008926 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002103 ; owl:someValuesFrom obo:CL_0000604 ] . obo:CL_0000752 obo:IAO_0000115 "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer." ; oboInOwl:hasDbXref "ZFA:0009322" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cone retinal bipolar cell" ; rdfs:subClassOf obo:CL_0000748, [ a owl:Restriction ; owl:onProperty obo:RO_0002103 ; owl:someValuesFrom obo:CL_0000573 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000748 [ a owl:Restriction ; owl:onProperty obo:RO_0002103 ; owl:someValuesFrom obo:CL_0000573 ] ) ] . obo:CL_0000753 obo:IAO_0000115 "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell body of these cells is in the middle of the inner plexiform layer. The dendritic tree is stout and the axon terminates in sublamina 1. The axonal terminal is wide and has only a few varicosities." ; oboInOwl:hasExactSynonym "DB1 cone bipolar cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type 1 cone bipolar cell (sensu Mus)" ; rdfs:subClassOf obo:CL_0000752, [ a owl:Restriction ; owl:onProperty obo:RO_0002102 ; owl:someValuesFrom obo:UBERON_0008922 ] . obo:CL_0000754 obo:IAO_0000115 "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is not well filled and the dendrites are more delicate than in type 1 cells. The axon terminal is bushier and exhibits a dense plexus of varicosities in the inner part of sublamina 1 (Ghosh et al., 2004). It can be differentiated from other retinal bipolar neurons by its expression of marker genes: Neto1, Lhx3 and Irx-6 (Shekhar, 2016)." ; oboInOwl:hasExactSynonym "FMB cone bipolar cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type 2 cone bipolar cell (sensu Mus)" ; rdfs:subClassOf obo:CL_0000752, [ a owl:Restriction ; owl:onProperty obo:RO_0002102 ; owl:someValuesFrom obo:UBERON_0008922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_P50481 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_Q8R4I7 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_Q9ER75 ] ; owl:equivalentClass _:genid3167 . obo:CL_0000755 obo:IAO_0000115 "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is delicate and the dendritic tips appear small when compared with type 1 cells. The axon terminal is stratified and restricted to sublamina 2 of the inner plexiform layer." ; oboInOwl:hasExactSynonym "DB2 cone bipolar cell" ; a owl:Class ; rdfs:label "type 3 cone bipolar cell (sensu Mus)" ; rdfs:subClassOf obo:CL_0000752, [ a owl:Restriction ; owl:onProperty obo:RO_0002102 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002103 ; owl:someValuesFrom obo:CL_0000604 ] . obo:CL_0000756 obo:IAO_0000115 "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell has a diffuse axon terminal with varicosities in sublaminae 1 and 2 of the inner plexiform layer." ; oboInOwl:hasExactSynonym "DB3 cone bipolar cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type 4 cone bipolar cell (sensu Mus)" ; rdfs:subClassOf obo:CL_0000752, [ a owl:Restriction ; owl:onProperty obo:RO_0002102 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002102 ; owl:someValuesFrom obo:UBERON_0008924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002103 ; owl:someValuesFrom obo:CL_0000604 ] . obo:CL_0000757 obo:IAO_0000115 "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is restricted to sublamina 3 of the inner plexiform layer. It is narrowly stratified and branched. The dendritic tree has many delicate branches." ; oboInOwl:hasExactSynonym "DB4 cone bipolar cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type 5 cone bipolar cell (sensu Mus)" ; rdfs:subClassOf obo:CL_0000752, [ a owl:Restriction ; owl:onProperty obo:RO_0002102 ; owl:someValuesFrom obo:UBERON_0008924 ] . obo:CL_0000758 obo:IAO_0000115 "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The cell has a loose, delicate axon terminal that opens in sublamina 3 of the inner plexiform layer and descends into sublamina 4." ; oboInOwl:hasExactSynonym "DB5 cone bipolar cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type 6 cone bipolar cell (sensu Mus)" ; rdfs:subClassOf obo:CL_0000752, [ a owl:Restriction ; owl:onProperty obo:RO_0002102 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0000759 obo:IAO_0000115 "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is narrowly stratified and are found just below a calretinin-expressing band in sublamina 4 of the inner plexiform layer." ; oboInOwl:hasExactSynonym "IMB cone bipolar cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type 7 cone bipolar cell (sensu Mus)" ; rdfs:subClassOf obo:CL_0000752, [ a owl:Restriction ; owl:onProperty obo:RO_0002102 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0000760 obo:IAO_0000115 "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. This cell has the widest dendritic field and the widest axon terminal of all retinal bipolar cells. The axon terminal is delicate and stratified through sublaminae 4 and 5 of the inner plexiform layer." ; oboInOwl:hasExactSynonym "DB6 cone bipolar cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type 8 cone bipolar cell (sensu Mus)" ; rdfs:subClassOf obo:CL_0000752, [ a owl:Restriction ; owl:onProperty obo:RO_0002102 ; owl:someValuesFrom obo:UBERON_0008925 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002102 ; owl:someValuesFrom obo:UBERON_0008926 ] . obo:CL_0000761 obo:IAO_0000115 "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The dendritic tree is wide and the dendritic convergence indicates cone selectivity. The axon terminal is sparsely branched and terminates in sublamina 5 of the inner plexiform layer." ; oboInOwl:hasExactSynonym "BB cone bipolar cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type 9 cone bipolar cell (sensu Mus)" ; rdfs:subClassOf obo:CL_0000752, [ a owl:Restriction ; owl:onProperty obo:RO_0002102 ; owl:someValuesFrom obo:UBERON_0008926 ] . obo:CL_0000762 obo:IAO_0000115 "A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates." ; oboInOwl:hasDbXref "ZFA:0009323" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:comment "Note that this is a non-mammalian cell type. Use platelet ; CL:0000233 for thrombocytes (platelets) in mammals." ; rdfs:label "nucleated thrombocyte" ; rdfs:subClassOf obo:CL_0000226, obo:CL_0000763, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000828 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007596 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000763 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007596 ] ) ] . obo:CL_0000763 obo:IAO_0000115 "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." ; oboInOwl:hasDbXref "BTO:0001441", "CALOHA:TS-0647", "MESH:D022423", "ZFA:0009324" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "myeloid cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000255, obo:CL_0000988, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000049 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000988 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000049 ] ) ] ; skos:prefLabel "myeloid cell" . obo:CL_0000764 obo:IAO_0000115 "A immature or mature cell in the lineage leading to and including erythrocytes." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "CALOHA:TS-0290", "FMA:62845", "FMA:83516", "ZFA:0009325" ; oboInOwl:hasExactSynonym "erythropoietic cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes." ; rdfs:label "erythroid lineage cell" ; rdfs:subClassOf obo:CL_0000763 ; skos:prefLabel "erythroid lineage cell" . obo:CL_0000765 obo:IAO_0000115 "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." ; oboInOwl:hasDbXref "BTO:0001571", "CALOHA:TS-0289", "FMA:83504", "MESH:D004900", "ZFA:0005237" ; oboInOwl:hasExactSynonym "normoblast" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset ; a owl:Class ; rdfs:label "erythroblast" ; rdfs:subClassOf obo:CL_0000764, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005634 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0005730 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000547 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030218 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000764 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005634 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0005730 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030218 ] ) ] ; skos:prefLabel "erythroblast" . obo:CL_0000766 obo:IAO_0000115 "A cell of the monocyte, granulocyte, or mast cell lineage." ; oboInOwl:hasDbXref "ZFA:0009326" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "myeloid leukocyte" ; rdfs:subClassOf obo:CL_0000738, obo:CL_0000763 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000738 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000049 ] ) ] . obo:CL_0000767 obo:IAO_0000115 "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "polymorphonuclear leucocyte", "polymorphonuclear leukocyte" ; oboInOwl:hasDbXref "BTO:0000129", "CALOHA:TS-0073", "FMA:62862" ; oboInOwl:hasExactSynonym "basophilic leucocyte", "basophilic leukocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive." ; rdfs:label "basophil" ; rdfs:subClassOf obo:CL_0000094, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001344 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001950 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001255 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001865 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000007431 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000094 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001344 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001950 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000007431 ] ) ] . obo:CL_0000768 obo:IAO_0000115 "Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking." ; oboInOwl:hasExactSynonym "immature basophilic leucocyte", "immature basophilic leukocyte" ; a owl:Class ; rdfs:label "immature basophil" ; rdfs:subClassOf obo:CL_0000767, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017509 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000830 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000767 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017509 ] ) ] . obo:CL_0000769 obo:IAO_0000115 "A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive." ; oboInOwl:hasDbXref "FMA:84198" ; a owl:Class ; rdfs:label "basophilic metamyelocyte" ; rdfs:subClassOf obo:CL_0000768, obo:CL_0002192, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017507 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000792 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042582 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0070820 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001456 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001892 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002031 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000614 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000768 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017507 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000792 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042582 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0070820 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001892 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002031 ] ) ] . obo:CL_0000770 obo:IAO_0000115 "A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." ; a owl:Class ; rdfs:label "band form basophil" ; rdfs:subClassOf obo:CL_0000768, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017506 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000769 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000768 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017506 ] ) ] . obo:CL_0000771 obo:IAO_0000115 "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "polymorphonuclear leucocyte", "polymorphonuclear leukocyte" ; oboInOwl:hasDbXref "BTO:0000399", "CALOHA:TS-0279", "FMA:62861", "MESH:D004804" ; oboInOwl:hasExactSynonym "eosinocyte", "eosinophilic granulocyte", "eosinophilic leucocyte", "eosinophilic leukocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte." ; rdfs:label "eosinophil" ; rdfs:subClassOf obo:CL_0000094, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001254 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001255 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000005178 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000094 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001254 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000005178 ] ) ] . obo:CL_0000772 obo:IAO_0000115 "Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking." ; oboInOwl:hasExactSynonym "immature eosinocyte", "immature eosinophilic leucocyte", "immature eosinophilic leukocyte" ; a owl:Class ; rdfs:label "immature eosinophil" ; rdfs:subClassOf obo:CL_0000771, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017509 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000833 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000771 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017509 ] ) ] . obo:CL_0000773 obo:IAO_0000115 "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative." ; a owl:Class ; rdfs:label "eosinophilic metamyelocyte" ; rdfs:subClassOf obo:CL_0000772, obo:CL_0002192, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017502 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017507 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000792 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042582 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0070820 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001456 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001892 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002031 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000612 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000772 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017502 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017507 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000792 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042582 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0070820 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001892 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002031 ] ) ] . obo:CL_0000774 obo:IAO_0000115 "A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature eosinophil." ; a owl:Class ; rdfs:label "band form eosinophil" ; rdfs:subClassOf obo:CL_0000772, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017506 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000773 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000772 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017506 ] ) ] . obo:CL_0000775 obo:IAO_0000115 "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "PMN", "poly", "polymorphonuclear leucocyte", "polymorphonuclear leukocyte", "polymorphonuclear neutrophil", "polynuclear neutrophilic leucocyte", "polynuclear neutrophilic leukocyte" ; oboInOwl:hasDbXref "BTO:0000130", "CALOHA:TS-0688", "FMA:62860", "MESH:D009504", "ZFA:0009327" ; oboInOwl:hasExactSynonym "neutrocyte", "neutrophil leucocyte", "neutrophil leukocyte", "neutrophilic leucocyte", "neutrophilic leukocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "neutrophil" ; rdfs:subClassOf obo:CL_0000094, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001479 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000094 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001479 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ] ) ] . obo:CL_0000776 obo:IAO_0000115 "Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking." ; oboInOwl:hasDbXref "ZFA:0009328" ; oboInOwl:hasExactSynonym "immatuer neutrophilic leukocyte", "immature neutrocyte", "immature neutrophil leucocyte", "immature neutrophil leukocyte", "immature neutrophilic leucocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "immature neutrophil" ; rdfs:subClassOf obo:CL_0000775, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017509 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000564 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000775 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017509 ] ) ] . obo:CL_0000777 obo:IAO_0000115 "A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling." ; oboInOwl:hasBroadSynonym "mesangial cell" ; a owl:Class ; rdfs:label "mesangial phagocyte" ; rdfs:subClassOf obo:CL_0000864, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002320 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048771 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000864 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002320 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0019882 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048771 ] ) ] . obo:CL_0000778 obo:IAO_0000115 "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." ; oboInOwl:hasDbXref "ZFA:0009329" ; a owl:Class ; rdfs:comment "Morphology: mononuclear, highly vesicular." ; rdfs:label "mononuclear osteoclast" ; rdfs:subClassOf obo:CL_0000092, obo:CL_0000113 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000092 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] ) ] . obo:CL_0000779 obo:IAO_0000115 "A specialized multinuclear osteoclast, forming a syncytium through the fusion of mononuclear precursor cells, associated with the absorption and removal of bone." ; oboInOwl:hasExactSynonym "multinucleated osteoclast" ; a owl:Class ; rdfs:comment "Morphology: multinucleated, highly vesicular." ; rdfs:label "multinuclear osteoclast" ; rdfs:subClassOf obo:CL_0000092, obo:CL_0000783, obo:CL_4052002, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000778 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000092 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] ) ] . obo:CL_0000780 obo:IAO_0000115 "A specialized multinuclear osteoclast associated with the absorption and removal of cementum." ; oboInOwl:hasExactSynonym "multinucleated odontoclast" ; a owl:Class ; rdfs:comment "Morphology: multinucleated, highly vesicular; location: roots of deciduous (milk) teeth." ; rdfs:label "multinuclear odontoclast" ; rdfs:subClassOf obo:CL_0000588, obo:CL_0000779, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000781 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000588 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] ) ] . obo:CL_0000781 obo:IAO_0000115 "A specialized mononuclear osteoclast associated with the absorption and removal of cementum." ; oboInOwl:hasDbXref "ZFA:0009330" ; a owl:Class ; rdfs:comment "Morphology: Mononuclear, highly vesicular; location: roots of deciduous (milk) teeth." ; rdfs:label "mononuclear odontoclast" ; rdfs:subClassOf obo:CL_0000588, obo:CL_0000778 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000588 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] ) ] . obo:CL_0000782 obo:IAO_0000115 "A dendritic cell of the myeloid lineage." ; oboInOwl:hasBroadSynonym "interdigitating cell", "veiled cell" ; oboInOwl:hasDbXref "BTO:0004721" ; oboInOwl:hasExactSynonym "CD11c+CD123- DC", "mDC" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8)." ; rdfs:label "myeloid dendritic cell" ; rdfs:subClassOf obo:CL_0000766, obo:CL_0000990, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001865 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000763 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000763 ] ) ] . obo:CL_0000783 obo:IAO_0000115 "A phagocyte formed by the fusion of mononuclear phagocytes." ; a owl:Class ; rdfs:label "multinucleated phagocyte" ; rdfs:subClassOf obo:CL_0000228, obo:CL_0000518 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000518 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] ) ] . obo:CL_0000784 obo:IAO_0000115 "A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0004625" ; oboInOwl:hasExactSynonym "DC2", "IPC", "T-associated plasma cell", "interferon-producing cell", "lymphoid dendritic cell", "pDC", "plasmacytoid T cell", "plasmacytoid monocyte", "type 2 DC" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "plasmacytoid dendritic cell" ; rdfs:subClassOf obo:CL_0000451, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032606 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000451 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032606 ] ) ] . obo:CL_0000785 obo:IAO_0000115 "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." ; oboInOwl:hasDbXref "ZFA:0009331" ; oboInOwl:hasExactSynonym "mature B lymphocyte", "mature B-cell", "mature B-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Mature B cells are also reportedly CD10-negative, CD19-positive, CD22-positive, CD34-negative, CD48-positive, CD79a-positive, CD84-positive, CD127-negative, CD352-positive, RAG-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Transcription factors expressed: Pax5-positive." ; rdfs:label "mature B cell" ; rdfs:subClassOf obo:CL_0000145, obo:CL_0001201, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000818 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042113 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0002335 ] ; owl:disjointWith obo:CL_0000816, obo:CL_0000817, obo:CL_0000818 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001201 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002504 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0002335 ] ) ] . obo:CL_0000786 obo:IAO_0000115 "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000392", "FMA:70574", "MESH:D010950", "ZFA:0009332" ; oboInOwl:hasExactSynonym "plasma B cell", "plasma B-cell", "plasmacyte", "plasmocyte" ; oboInOwl:hasRelatedSynonym "effector B cell", "effector B-cell" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive." ; rdfs:label "plasma cell" ; rdfs:subClassOf obo:CL_0000946, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017508 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005794 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0019814 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042613 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001935 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000980 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000946 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017508 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005794 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0019814 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001935 ] ) ] . obo:CL_0000787 obo:IAO_0000115 "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0009333" ; oboInOwl:hasExactSynonym "memory B lymphocyte", "memory B-cell", "memory B-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Memory B-cells are also reportedly CD5-negative, CD10-negative, CD21-positive, CD22-positive, CD23-negative, CD24-positive, CD25-positive, CD27-positive, CD34-negative, CD38-negative, CD40-positive, CD43-negative, CD44-positive, CD45-positive, CD53-positive, CD80-negative, CD81-negative, CD86-positive, and CD196/CCR6-positive." ; rdfs:label "memory B cell" ; rdfs:subClassOf obo:CL_0000785, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001935 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0002344 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001935 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0002344 ] ) ] . obo:CL_0000788 obo:IAO_0000115 "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0009334" ; oboInOwl:hasExactSynonym "naive B lymphocyte", "naive B-cell", "naive B-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'naive B cell'. Per DSD: Naive B cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive." ; rdfs:label "naive B cell" ; rdfs:subClassOf obo:CL_0000785, [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0002344 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001963 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0002344 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001963 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] ) ] . obo:CL_0000789 obo:IAO_0000115 "A T cell that expresses an alpha-beta T cell receptor complex." ; oboInOwl:hasDbXref "ZFA:0009335" ; oboInOwl:hasExactSynonym "alpha-beta T lymphocyte", "alpha-beta T-cell", "alpha-beta T-lymphocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset ; a owl:Class ; rdfs:label "alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000084, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042105 ] ; owl:disjointWith obo:CL_0000798 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042105 ] ) ] . obo:CL_0000790 obo:IAO_0000115 "An alpha-beta T cell that has an immature phenotype and has not completed T cell selection." ; oboInOwl:hasExactSynonym "immature alpha-beta T lymphocyte", "immature alpha-beta T-cell", "immature alpha-beta T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "immature alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000789, obo:CL_0002420 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000789 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0045058 ] ) ] . obo:CL_0000791 obo:IAO_0000115 "A alpha-beta T cell that has a mature phenotype." ; oboInOwl:hasExactSynonym "mature alpha-beta T lymphocyte", "mature alpha-beta T-cell", "mature alpha-beta T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "mature alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000789, obo:CL_0002419, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000790 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000789 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0045058 ] ) ] . obo:CL_0000792 obo:IAO_0000115 "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." ; oboInOwl:hasBroadSynonym "Treg", "suppressor T cell", "suppressor T lymphocyte", "suppressor T-cell", "suppressor T-lymphocyte" ; oboInOwl:hasExactSynonym "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte", "CD4-positive, CD25-positive, alpha-beta regulatory T-cell", "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'Treg'. The inclusion of CD127lo in the logical definition is compatible with both human and mouse T cells of this subtype." ; rdfs:label "CD4-positive, CD25-positive, alpha-beta regulatory T cell" ; rdfs:subClassOf obo:CL_0000624, obo:CL_0000815, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001869 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001869 ] ) ] . obo:CL_0000793 obo:IAO_0000115 "A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "IEL", "intraepithelial lymphocyte" ; oboInOwl:hasExactSynonym "CD4-positive, alpha-beta intraepithelial T lymphocyte", "CD4-positive, alpha-beta intraepithelial T-cell", "CD4-positive, alpha-beta intraepithelial T-lymphocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "CD4-positive, alpha-beta intraepithelial T cell" ; rdfs:subClassOf obo:CL_0000624, obo:CL_0000797, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000810 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001277 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002385 ] ) ] . obo:CL_0000794 obo:IAO_0000115 "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "cytotoxic T cell", "cytotoxic T lymphocyte", "cytotoxic T-cell", "cytotoxic T-lymphocyte", "killer T cell", "killer T lymphocyte", "killer T-cell", "killer T-lymphocyte" ; oboInOwl:hasDbXref "CALOHA:TS-0190" ; oboInOwl:hasExactSynonym "CD8-positive, alpha-beta cytotoxic T lymphocyte", "CD8-positive, alpha-beta cytotoxic T-cell", "CD8-positive, alpha-beta cytotoxic T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Note that while T cells of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo." ; rdfs:label "CD8-positive, alpha-beta cytotoxic T cell" ; rdfs:subClassOf obo:CL_0000625, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003466 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003499 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000906 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001913 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0033380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000625 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003466 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003499 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001913 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0033380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ) ] . obo:CL_0000795 obo:IAO_0000115 "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." ; oboInOwl:hasBroadSynonym "suppressor T cell", "suppressor T lymphocyte", "suppressor T-cell", "suppressor T-lymphocyte" ; oboInOwl:hasExactSynonym "CD8+ T(reg)", "CD8+ Treg", "CD8+ regulatory T cell", "CD8-positive T(reg)", "CD8-positive Treg", "CD8-positive, alpha-beta Treg", "CD8-positive, alpha-beta regulatory T lymphocyte", "CD8-positive, alpha-beta regulatory T-cell", "CD8-positive, alpha-beta regulatory T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "CD8-positive, alpha-beta regulatory T cell" ; rdfs:subClassOf obo:CL_0000625, obo:CL_0000815 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000625 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] ) ] . obo:CL_0000796 obo:IAO_0000115 "A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "IEL", "intraepithelial lymphocyte" ; oboInOwl:hasExactSynonym "CD8-positive, alpha-beta intraepithelial T lymphocyte", "CD8-positive, alpha-beta intraepithelial T-cell", "CD8-positive, alpha-beta intraepithelial T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "CD8-alpha-beta-positive, alpha-beta intraepithelial T cell" ; rdfs:subClassOf obo:CL_0000797, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000025402 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000797 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000025402 ] ) ] . obo:CL_0000797 obo:IAO_0000115 "A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." ; oboInOwl:hasBroadSynonym "IEL", "intraepithelial lymphocyte" ; oboInOwl:hasExactSynonym "alpha-beta intraepithelial T lymphocyte", "alpha-beta intraepithelial T-cell", "alpha-beta intraepithelial T-lymphocyte" ; a owl:Class ; rdfs:label "alpha-beta intraepithelial T cell" ; rdfs:subClassOf obo:CL_0000791, obo:CL_0002496 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000791 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001277 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002385 ] ) ] . obo:CL_0000798 obo:IAO_0000115 "A T cell that expresses a gamma-delta T cell receptor complex." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0009336" ; oboInOwl:hasExactSynonym "gamma-delta T lymphocyte", "gamma-delta T-cell", "gamma-delta T-lymphocyte", "gammadelta T cell" ; oboInOwl:hasRelatedSynonym "gd T cell" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways." ; rdfs:label "gamma-delta T cell" ; rdfs:subClassOf obo:CL_0000084, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042106 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042106 ] ) ] . obo:CL_0000799 obo:IAO_0000115 "A gamma-delta T cell that has an immature phenotype." ; oboInOwl:hasDbXref "ZFA:0009337" ; oboInOwl:hasExactSynonym "immature gamma-delta T lymphocyte", "immature gamma-delta T-cell", "immature gamma-delta T-lymphocyte" ; a owl:Class ; rdfs:comment "Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways." ; rdfs:label "immature gamma-delta T cell" ; rdfs:subClassOf obo:CL_0000798, obo:CL_0002420, [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0042492 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000807 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000798 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0042492 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0045058 ] ) ] . obo:CL_0000800 obo:IAO_0000115 "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location." ; oboInOwl:hasDbXref "ZFA:0009338" ; oboInOwl:hasExactSynonym "mature gamma-delta T lymphocyte", "mature gamma-delta T-cell", "mature gamma-delta T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "mature gamma-delta T cell" ; rdfs:subClassOf obo:CL_0000798, obo:CL_0002419, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000799 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000798 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0045058 ] ) ] . obo:CL_0000801 obo:IAO_0000115 "A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses." ; oboInOwl:hasBroadSynonym "IEL", "intraepithelial lymphocyte" ; oboInOwl:hasDbXref "ZFA:0009339" ; oboInOwl:hasExactSynonym "gamma-delta intraepithelial T lymphocyte", "gamma-delta intraepithelial T-cell", "gamma-delta intraepithelial T-lymphocyte" ; a owl:Class ; rdfs:label "gamma-delta intraepithelial T cell" ; rdfs:subClassOf obo:CL_0000800, obo:CL_0002496 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000800 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001277 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002385 ] ) ] . obo:CL_0000802 obo:IAO_0000115 "A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "IEL", "intraepithelial lymphocyte" ; oboInOwl:hasExactSynonym "CD8-positive, gamma-delta intraepithelial T lymphocyte", "CD8-positive, gamma-delta intraepithelial T-cell", "CD8-positive, gamma-delta intraepithelial T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "CD8-alpha alpha positive, gamma-delta intraepithelial T cell" ; rdfs:subClassOf obo:CL_0000801, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001084 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000801 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001084 ] ) ] . obo:CL_0000803 obo:IAO_0000115 "A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative." ; oboInOwl:hasBroadSynonym "IEL", "intraepithelial lymphocyte" ; oboInOwl:hasExactSynonym "CD4-positive, gamma-delta intraepithelial T lymphocyte", "CD4-positive, gamma-delta intraepithelial T-cell", "CD4-positive, gamma-delta intraepithelial T-lymphocyte" ; a owl:Class ; rdfs:label "CD4-negative CD8-negative gamma-delta intraepithelial T cell" ; rdfs:subClassOf obo:CL_0000801, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000801 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] ) ] . obo:CL_0000804 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000084 ; a owl:Class ; owl:deprecated true . obo:CL_0000805 obo:IAO_0000115 "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive." ; oboInOwl:hasExactSynonym "ISP", "T.ISP.th", "immature single positive T cell", "immature single positive T lymphocyte", "immature single positive T-lymphocyte" ; a owl:Class ; rdfs:comment "Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages." ; rdfs:label "immature single positive thymocyte" ; rdfs:subClassOf obo:CL_0000893, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001307 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0043384 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000025402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000808 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000893 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0043384 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000025402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0000806 obo:IAO_0000115 "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive." ; oboInOwl:hasExactSynonym "DN2 alpha-beta immature T lymphocyte", "DN2 alpha-beta immature T-cell", "DN2 alpha-beta immature T-lymphocyte", "DN2 cell", "DN2 immature T cell", "TN2 cell", "TN2 thymocyte", "double negative 2", "preT.DN2.Th" ; a owl:Class ; rdfs:comment "Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains. Also, there is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'." ; rdfs:label "DN2 thymocyte" ; rdfs:subClassOf obo:CL_0002489, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000894 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000893 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] ) ] . obo:CL_0000807 obo:IAO_0000115 "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." ; oboInOwl:hasBroadSynonym "early cortical thymocyte" ; oboInOwl:hasExactSynonym "DN3 alpha-beta immature T lymphocyte", "DN3 alpha-beta immature T-cell", "DN3 alpha-beta immature T-lymphocyte", "DN3 cell", "DN3 immature T cell", "TN3 cell", "TN3 thymocyte", "double negative 3", "preT.DN3.Th" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'." ; rdfs:label "DN3 thymocyte" ; rdfs:subClassOf obo:CL_0002489, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001307 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0043384 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000806 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000893 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0043384 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] ) ] . obo:CL_0000808 obo:IAO_0000115 "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." ; oboInOwl:hasBroadSynonym "early cortical thymocyte" ; oboInOwl:hasExactSynonym "DN4 alpha-beta immature T lymphocyte", "DN4 alpha-beta immature T-lymphocyte", "DN4 cell", "DN4 immature T cell", "DN4 immature T-cell", "T.DN4.th", "double negative 4" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'." ; rdfs:label "DN4 thymocyte" ; rdfs:subClassOf obo:CL_0002489, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001307 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0043384 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000807 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000893 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0043384 ] ) ] . obo:CL_0000809 obo:IAO_0000115 "A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "late cortical thymocyte" ; oboInOwl:hasExactSynonym "DP cell", "DP thymocyte", "double-positive, alpha-beta immature T lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Thymocytes of this stage are undergoing positive and negative selection." ; rdfs:label "double-positive, alpha-beta thymocyte" ; rdfs:subClassOf obo:CL_0000790, obo:CL_0000893, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000025402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000805 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000790 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000025402 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" . obo:CL_0000810 obo:IAO_0000115 "An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative." ; oboInOwl:hasExactSynonym "CD4-positive, alpha-beta immature T lymphocyte", "CD4-positive, alpha-beta immature T-cell", "CD4-positive, alpha-beta immature T-lymphocyte", "SP CD4 cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "CD4-positive, alpha-beta thymocyte" ; rdfs:subClassOf obo:CL_0000790, obo:CL_0000893, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000809 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000790 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] ) ] . obo:CL_0000811 obo:IAO_0000115 "An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative." ; oboInOwl:hasExactSynonym "CD8-positive, alpha-beta immature T lymphocyte", "CD8-positive, alpha-beta immature T-cell", "CD8-positive, alpha-beta immature T-lymphocyte", "SP CD8 cell" ; oboInOwl:hasRelatedSynonym "CD8-positive, alpha-beta immature T cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "CD8-positive, alpha-beta thymocyte" ; rdfs:subClassOf obo:CL_0000790, obo:CL_0000893, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000025402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000809 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000790 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000025402 ] ) ] . obo:CL_0000812 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000084 ; a owl:Class ; owl:deprecated true . obo:CL_0000813 obo:IAO_0000115 "A long-lived, antigen-experienced T cell that has acquired a memory phenotype including distinct surface markers and the ability to differentiate into an effector T cell upon antigen reexposure." ; oboInOwl:hasDbXref "BTO:0003435", "ZFA:0009342" ; oboInOwl:hasExactSynonym "memory T lymphocyte", "memory T-cell", "memory T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "memory T cell" ; rdfs:subClassOf obo:CL_0002419, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001603 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0043379 ] ; owl:disjointWith obo:CL_0000898 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002419 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001603 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0002286 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0043379 ] ) ] . obo:CL_0000814 obo:IAO_0000115 "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "mature NK T lymphocyte", "mature NK T-cell", "mature NK T-lymphocyte", "mature NKT cell", "mature natural killer T cell", "mature natural killer T lymphocyte", "mature natural killer T-cell", "mature natural killer T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "mature NK T cell" ; rdfs:subClassOf obo:CL_0000791, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001874 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002042 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032394 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045087 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000791 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001874 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032394 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045087 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ) ] . obo:CL_0000815 obo:IAO_0000115 "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "suppressor T cell", "suppressor T lymphocyte", "suppressor T-cell", "suppressor T-lymphocyte" ; oboInOwl:hasDbXref "BTO:0004520", "FMA:84070", "MESH:D050378" ; oboInOwl:hasExactSynonym "Treg", "regulatory T lymphocyte", "regulatory T-cell", "regulatory T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta." ; rdfs:label "regulatory T cell" ; rdfs:subClassOf obo:CL_0002419, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002419 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] ) ] . obo:CL_0000816 obo:IAO_0000115 "An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0009343" ; oboInOwl:hasExactSynonym "immature B lymphocyte", "immature B-cell", "immature B-lymphocyte", "newly formed B cell" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive." ; rdfs:label "immature B cell" ; rdfs:subClassOf obo:CL_0001201, [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0045190 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000954 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001201 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0045190 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] ) ] . obo:CL_0000817 obo:IAO_0000115 "A precursor B cell is a B cell with the phenotype CD10-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0001133", "CALOHA:TS-0819", "ZFA:0009344" ; oboInOwl:hasRelatedSynonym "pre-B cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "precursor B cell" ; rdfs:subClassOf obo:CL_0001201, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071753 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001898 ] ; owl:disjointWith obo:CL_0000826 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001201 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001898 ] ) ] . obo:CL_0000818 obo:IAO_0000115 "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0009345" ; oboInOwl:hasExactSynonym "transitional B cell", "transitional stage B lymphocyte", "transitional stage B-cell", "transitional stage B-lymphocyte" ; oboInOwl:hasNarrowSynonym "T1 B cell", "T2 B cell", "T3 B cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'transitional B cell'." ; rdfs:label "transitional stage B cell" ; rdfs:subClassOf obo:CL_0001201, [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0002335 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000816 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001201 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0002335 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0000819 obo:IAO_0000115 "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." ; oboInOwl:hasExactSynonym "B-1 B lymphocyte", "B-1 B-cell", "B-1 B-lymphocyte", "B-1 cell", "B1 B cell", "B1 B lymphocyte", "B1 B-cell", "B1 B-lymphocyte", "B1 cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "There are small numbers of B-1 cells found in the lymph nodes and spleen, while larger numbers can be found in the peritoneal and pleural cavities. B-1 B cells are reportedly CD11b-positive, CD20-positive, CD21-positive, CD27-positive, CD44-positive, CD45RB-positive, CD48-positive, CD70-negative, CD150-positive, CD244-negative, CD352-positive, sIgM-positive, and sIgD-low." ; rdfs:label "B-1 B cell" ; rdfs:subClassOf obo:CL_0000785, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045087 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0071753 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045087 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0071753 ] ) ] . obo:CL_0000820 obo:IAO_0000115 "A B-1 B cell that has the phenotype CD5-positive." ; oboInOwl:hasExactSynonym "B-1a B lymphocyte", "B-1a B-cell", "B-1a B-lymphocyte", "B1a B cell", "B1a B lymphocyte", "B1a B-cell", "B1a B-lymphocyte", "B1a cell", "CD5(+) B1 cell", "CD5+ B1 cell", "CD5-positive B1 cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "B-1a B cell" ; rdfs:subClassOf obo:CL_0000819, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001839 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000819 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001839 ] ) ] . obo:CL_0000821 obo:IAO_0000115 "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell." ; oboInOwl:hasExactSynonym "B-1b B lymphocyte", "B-1b B-cell", "B-1b B-lymphocyte", "B1b B cell", "B1b B lymphocyte", "B1b B-cell", "B1b B-lymphocyte", "B1b cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "B-1b B cell" ; rdfs:subClassOf obo:CL_0000819, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000819 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] ) ] . obo:CL_0000822 obo:IAO_0000115 "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." ; oboInOwl:hasExactSynonym "B-2 B lymphocyte", "B-2 B-cell", "B-2 B-lymphocyte", "B2 B cell", "B2 B lymphocyte", "B2 B-cell", "B2 B-lymphocyte", "B2 cell" ; oboInOwl:hasRelatedSynonym "B-0 B cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "B-2 B cells are reportedly CD48-positive, CD244-negative, and CD352-positive." ; rdfs:label "B-2 B cell" ; rdfs:subClassOf obo:CL_0000785, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] ) ] . obo:CL_0000823 obo:IAO_0000115 "A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)." ; oboInOwl:hasDbXref "ZFA:0009346" ; oboInOwl:hasExactSynonym "immature NK cell" ; oboInOwl:hasRelatedSynonym "p-NK" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules." ; rdfs:label "immature natural killer cell" ; rdfs:subClassOf obo:CL_0000623, obo:CL_0001082, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000937 ] ; owl:disjointWith obo:CL_0000824, obo:CL_0000937 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000623 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001501 ] ) ] . obo:CL_0000824 obo:IAO_0000115 "A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "LAK cell", "lymphokine activated killer cell" ; oboInOwl:hasDbXref "ZFA:0009347" ; oboInOwl:hasExactSynonym "mature NK cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mature natural killer cell" ; rdfs:subClassOf obo:CL_0000623, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000823 ] . obo:CL_0000825 obo:IAO_0000115 "A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." ; oboInOwl:hasDbXref "ZFA:0009348" ; oboInOwl:hasExactSynonym "NKP", "natural killer cell progenitor", "pro-natural killer cell" ; oboInOwl:hasRelatedSynonym "null cell", "preNK cell" ; a owl:Class ; rdfs:comment "Most markers only described for human pro NK cells." ; rdfs:label "pro-NK cell" ; rdfs:subClassOf obo:CL_0000838, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001874 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001381 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001898 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000051 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000838 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001874 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001381 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001898 ] ) ] . obo:CL_0000826 obo:IAO_0000115 "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "pre-pro B cell" ; oboInOwl:hasDbXref "BTO:0003104", "ZFA:0009349" ; oboInOwl:hasExactSynonym "pro-B lymphocyte", "pro-B-cell", "pro-B-lymphocyte", "progenitor B cell", "progenitor B lymphocyte", "progenitor B-cell", "progenitor B-lymphocyte" ; oboInOwl:hasRelatedSynonym "pre-B cell (Philadelphia nomenclature)" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative." ; rdfs:label "pro-B cell" ; rdfs:subClassOf obo:CL_0000838, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001903 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000006611 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0033152 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000051 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000838 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001903 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000006611 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0033152 ] ) ] . obo:CL_0000827 obo:IAO_0000115 "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." ; oboInOwl:hasDbXref "ZFA:0009350" ; oboInOwl:hasExactSynonym "pro-T lymphocyte", "progenitor T cell" ; oboInOwl:hasNarrowSynonym "DN1 cell", "DN1 thymocyte", "TN1 cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "pro-T cell" ; rdfs:subClassOf obo:CL_0000838, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000051 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030217 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000838 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030217 ] ) ] . obo:CL_0000828 obo:IAO_0000115 "A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates." ; oboInOwl:hasDbXref "ZFA:0009351" ; a owl:Class ; rdfs:comment "Note that this is a non-mammalian cell type." ; rdfs:label "thromboblast" ; rdfs:subClassOf obo:CL_0000226, obo:CL_0000763, obo:CL_0000839, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000050 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002574 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000839 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002574 ] ) ] . obo:CL_0000829 obo:IAO_0000115 "A myeloblast committed to the basophil lineage." ; a owl:Class ; rdfs:label "basophilic myeloblast" ; rdfs:subClassOf obo:CL_0000835, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030221 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000835 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030221 ] ) ] . obo:CL_0000830 obo:IAO_0000115 "A promyelocyte committed to the basophil lineage." ; oboInOwl:hasDbXref "FMA:84208" ; a owl:Class ; rdfs:label "basophilic promyelocyte" ; rdfs:subClassOf obo:CL_0000836, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000829 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030221 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000836 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030221 ] ) ] . obo:CL_0000831 obo:IAO_0000115 "A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative." ; oboInOwl:hasExactSynonym "MCP" ; oboInOwl:hasRelatedSynonym "CFU-MC", "CFU-Mast", "colony forming unit mast cell" ; a owl:Class ; rdfs:comment "MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa." ; rdfs:label "mast cell progenitor" ; rdfs:subClassOf obo:CL_0000763, obo:CL_0000839, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007858 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000005307 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001963 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002980 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000005178 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000016401 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002028 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0060374 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000009143 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000007431 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000839 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007858 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000005307 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001963 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002980 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000005178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000016401 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0060374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000009143 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000007431 ] ) ] . obo:CL_0000832 obo:IAO_0000115 "A myeloblast committed to the eosinophil lineage." ; a owl:Class ; rdfs:label "eosinophilic myeloblast" ; rdfs:subClassOf obo:CL_0000835, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000611 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030222 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000835 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030222 ] ) ] . obo:CL_0000833 obo:IAO_0000115 "A promyelocyte committed to the eosinophil lineage." ; oboInOwl:hasDbXref "FMA:84199" ; a owl:Class ; rdfs:label "eosinophilic promyelocyte" ; rdfs:subClassOf obo:CL_0000836, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000832 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030222 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000836 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030222 ] ) ] . obo:CL_0000834 obo:IAO_0000115 "A progenitor cell of the neutrophil lineage." ; oboInOwl:hasDbXref "ZFA:0009352" ; oboInOwl:hasRelatedSynonym "neutrophil stem cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "neutrophil progenitor cell" ; rdfs:subClassOf obo:CL_0000763, obo:CL_0002191, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000557 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030223 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002191 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030223 ] ) ] . obo:CL_0000835 obo:IAO_0000115 "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." ; oboInOwl:hasDbXref "BTO:0000187", "FMA:83524", "ZFA:0009353" ; a owl:Class ; rdfs:label "myeloblast" ; rdfs:subClassOf obo:CL_0000763, obo:CL_0002191, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017503 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000791 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0042582 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0040072 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000557 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002191 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017503 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000791 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0042582 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0040072 ] ) ] . obo:CL_0000836 obo:IAO_0000115 "A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "CALOHA:TS-0825", "FMA:83530" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "promyelocyte" ; rdfs:subClassOf obo:CL_0000763, obo:CL_0002191, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017503 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005730 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042582 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001483 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0040072 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001456 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001892 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000835 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000839 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017503 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005730 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042582 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0040072 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001892 ] ) ] . obo:CL_0000837 obo:IAO_0000115 "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000725", "CALOHA:TS-0448", "ZFA:0009354" ; oboInOwl:hasExactSynonym "MPP", "hemopoietic progenitor cell" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Markers differ between mouse and human." ; rdfs:label "hematopoietic multipotent progenitor cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000255, obo:CL_0008001, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000037 ] ; owl:disjointWith obo:CL_0002032 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000988 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] ) ] ; skos:prefLabel "hematopoietic multipotent progenitor cell" . obo:CL_0000838 obo:IAO_0000115 "A progenitor cell restricted to the lymphoid lineage." ; oboInOwl:hasBroadSynonym "lymphoid progenitor cell" ; oboInOwl:hasDbXref "BTO:0004731", "CALOHA:TS-2025", "FMA:70338", "ZFA:0009355" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Note that this is a class of cell types, not an identified single cell type." ; rdfs:label "lymphoid lineage restricted progenitor cell" ; rdfs:subClassOf obo:CL_0002031, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030098 ] ; owl:disjointWith obo:CL_0000839 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002031 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030098 ] ) ] . obo:CL_0000839 obo:IAO_0000115 "A progenitor cell restricted to the myeloid lineage." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "myeloid progenitor cell" ; oboInOwl:hasDbXref "BTO:0004730", "CALOHA:TS-2099", "FMA:70339", "ZFA:0009356" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Note that this is a class of cell types, not an identified single cell type." ; rdfs:label "myeloid lineage restricted progenitor cell" ; rdfs:subClassOf obo:CL_0002031, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030099 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002031 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030099 ] ) ] ; skos:prefLabel "myeloid lineage restricted progenitor cell" . obo:CL_0000840 obo:IAO_0000115 "An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasNarrowSynonym "immature myeloid dendritic cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "immature conventional dendritic cell" ; rdfs:subClassOf obo:CL_0000766, obo:CL_0000990, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001029 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001412 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001438 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0000841 obo:IAO_0000115 "A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node." ; oboInOwl:hasBroadSynonym "mature dendritic cell" ; oboInOwl:hasDbXref "FMA:83038" ; oboInOwl:hasNarrowSynonym "mature myeloid dendritic cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "mature conventional dendritic cell" ; rdfs:subClassOf obo:CL_0000766, obo:CL_0000990, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001310 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000840 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001412 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001438 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0000842 obo:IAO_0000115 "A leukocyte with a single non-segmented nucleus in the mature form." ; oboInOwl:hasDbXref "BTO:0000878", "CALOHA:TS-0768", "FMA:86713", "ZFA:0009357" ; oboInOwl:hasExactSynonym "mononuclear cell" ; oboInOwl:hasNarrowSynonym "peripheral blood mononuclear cell" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset ; a owl:Class ; rdfs:label "mononuclear leukocyte" ; rdfs:subClassOf obo:CL_0000226, obo:CL_0000738 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000738 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] ) ] . obo:CL_0000843 obo:IAO_0000115 "A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative." ; oboInOwl:hasExactSynonym "Fo B cell", "Fo B-cell", "follicular B lymphocyte", "follicular B-cell", "follicular B-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Follicular B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive." ; rdfs:label "follicular B cell" ; rdfs:subClassOf obo:CL_0000822, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002037 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001338 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001338 ] ) ] . obo:CL_0000844 obo:IAO_0000115 "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "GC B cell", "GC B lymphocyte", "GC B-cell", "GC B-lymphocyte", "germinal center B lymphocyte", "germinal center B-cell", "germinal center B-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive." ; rdfs:label "germinal center B cell" ; rdfs:subClassOf obo:CL_0000785, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010754 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000843 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010754 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] ) ] . obo:CL_0000845 obo:IAO_0000115 "A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "MZ B cell", "MZ B lymphocyte", "MZ B-cell", "MZ B-lymphocyte", "marginal zone B cell", "marginal zone B lymphocyte", "marginal zone B-cell", "marginal zone B-lymphocyte" ; oboInOwl:hasExactSynonym "B cell of marginal zone of spleen", "marginal zone of spleen B cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive." ; rdfs:label "marginal zone B cell of spleen" ; rdfs:subClassOf obo:CL_0000785, obo:CL_2000074, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001251 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001880 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002037 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001338 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042742 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0071753 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001251 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001880 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042742 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0071753 ] ) ] . obo:CL_0000846 obo:IAO_0000115 "An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "vestibular dark cell" ; rdfs:subClassOf obo:CL_0000066 . obo:CL_0000847 obo:IAO_0000115 "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob." ; oboInOwl:hasDbXref "ZFA:0009358" ; oboInOwl:hasExactSynonym "ciliated olfactory sensory neuron", "ciliated sensory neuron" ; a owl:Class ; rdfs:label "ciliated olfactory receptor neuron" ; rdfs:subClassOf obo:CL_0000064, obo:CL_0000207 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000207 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005929 ] ) ] . obo:CL_0000848 obo:IAO_0000115 "An olfactory receptor cell in which the apical ending of the dendrite is a knob that bears numerous microvilli." ; oboInOwl:hasDbXref "ZFA:0009359" ; oboInOwl:hasExactSynonym "microvillous olfactory sensory neuron" ; oboInOwl:hasRelatedSynonym "microvillous sensory neuron" ; a owl:Class ; rdfs:label "microvillous olfactory receptor neuron" ; rdfs:subClassOf obo:CL_0000207 . obo:CL_0000849 obo:IAO_0000115 "An olfactory receptor cell with short cilia growing in an invagination bordered by microvilli." ; oboInOwl:hasDbXref "ZFA:0009360" ; oboInOwl:hasExactSynonym "crypt cell", "crypt olfactory sensory neuron", "crypt sensory neuron" ; a owl:Class ; rdfs:label "crypt olfactory receptor neuron" ; rdfs:subClassOf obo:CL_0000207 . obo:CL_0000850 obo:IAO_0000115 "A neuron that releases serotonin as a neurotransmitter." ; oboInOwl:hasDbXref "FBbt:00005133", "MESH:D059326", "WBbt:0006837", "ZFA:0009361" ; oboInOwl:hasExactSynonym "5-HT neuron", "5-hydroxytryptamine neuron" ; oboInOwl:hasRelatedSynonym "serotinergic neuron" ; a owl:Class ; rdfs:label "serotonergic neuron" ; rdfs:subClassOf obo:CL_0000458, obo:CL_0000540, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0060096 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0060096 ] ) ] . obo:CL_0000851 obo:IAO_0000115 "Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded." ; oboInOwl:hasDbXref "ZFA:0009362" ; a owl:Class ; rdfs:label "neuromast mantle cell" ; rdfs:subClassOf obo:CL_0000151, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008904 ] ; owl:disjointWith obo:CL_0000855 . obo:CL_0000852 obo:IAO_0000115 "Neuromast support cell is a non-sensory cell of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; neuromast support cells are surrounded by neuromast mantle cells." ; oboInOwl:hasDbXref "ZFA:0009363" ; oboInOwl:hasExactSynonym "neuromast support cell" ; a owl:Class ; rdfs:label "neuromast supporting cell" ; rdfs:subClassOf obo:CL_0000255, obo:CL_0000630, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008904 ] ; owl:disjointWith obo:CL_0000855 . obo:CL_0000853 obo:IAO_0000115 "Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons." ; oboInOwl:hasDbXref "FMA:62302", "ZFA:0009364" ; oboInOwl:hasExactSynonym "olfactory epithelial support cell", "olfactory sustentacular cell", "supporting cell of olfactory epithelium", "sustentaculocyte of olfactory epithelium" ; a owl:Class ; rdfs:label "olfactory epithelial supporting cell" ; rdfs:subClassOf obo:CL_0000630, obo:CL_0002167 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000630 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001997 ] ) ] ; skos:prefLabel "olfactory epithelial supporting cell" . obo:CL_0000854 obo:IAO_0000115 "Interneuromast cell is a neuroectodermal cell deposited by the migrating lateral line primordium between the neuromasts. Interneuromast cells proliferate and migrate to form additional neuromasts." ; oboInOwl:hasDbXref "ZFA:0009365" ; a owl:Class ; rdfs:label "interneuromast cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000133, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000032 ] . obo:CL_0000855 obo:IAO_0000115 "Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." ; oboInOwl:hasBroadSynonym "hair cell" ; oboInOwl:hasDbXref "BTO:0004744", "ZFA:0009366" ; a owl:Class ; rdfs:label "sensory hair cell" ; rdfs:subClassOf obo:CL_0000199 . obo:CL_0000856 obo:IAO_0000115 "Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." ; oboInOwl:hasDbXref "ZFA:0009367" ; a owl:Class ; rdfs:label "neuromast hair cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000006, obo:CL_0000855, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008904 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000855 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008904 ] ) ] . obo:CL_0000857 obo:IAO_0000115 "A skeletal muscle myoblast that differentiates into slow muscle fibers." ; oboInOwl:hasDbXref "ZFA:0009368" ; a owl:Class ; rdfs:label "slow muscle myoblast" ; rdfs:subClassOf obo:CL_0000515, [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000189 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000056 [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000189 ] ) ] . obo:CL_0000858 obo:IAO_0000115 "A skeletal muscle myoblast that differentiates into fast muscle fibers." ; oboInOwl:hasDbXref "ZFA:0009369" ; a owl:Class ; rdfs:label "fast muscle myoblast" ; rdfs:subClassOf obo:CL_0000515, [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000190 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000056 [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000190 ] ) ] . obo:CL_0000859 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000061 ; a owl:Class ; owl:deprecated true . obo:CL_0000860 obo:IAO_0000115 "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Classical monocytes are a subtype of monocytes that are characterized by high CD14 but no CD16 expression. Emerging from the bone marrow and entering the bloodstream, these cells play central roles in immune responses and regulation of inflammation. CD14-positive CD16-negative monocytes form the majority of circulating monocytes in the body, typically contributing to around 80-90% of the total monocyte pool. The primary function of the classical monocytes is to serve in the frontline of host defense against infections. They are primed to migrate to sites of infection, and they express pattern recognition receptors that help them identify and phagocytose pathogens, leading to their destruction. Classical monocytes also contribute to inflammation by producing several pro-inflammatory cytokines including interleukins and tumor necrosis factors. In response to specific signals from tissues under pathological conditions, such as infection or injury, classical monocytes can leave the bloodstream and migrate towards the affected sites. Following their arrival, these cells differentiate into diverse cell types including macrophages and dendritic cells to combat specific pathogens or injury. Dysregulated monocyte activity can lead to the development of many human diseases including inflammation, infection, tissue injury, and various autoimmune diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasExactSynonym "inflammatory monocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Markers: CCR2+CXCCR1 (human, mouse, rat)." ; rdfs:label "classical monocyte" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000860" ; rdfs:subClassOf obo:CL_0000576, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002548 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006954 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001199 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000576 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002548 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006909 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006954 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001199 ] ) ] . obo:CL_0000861 obo:IAO_0000115 "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." ; oboInOwl:hasDbXref "FMA:84643", "FMA:84645" ; oboInOwl:hasExactSynonym "free macrophage", "wandering histiocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response)." ; rdfs:label "elicited macrophage" ; rdfs:subClassOf obo:CL_0000235, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0006954 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002064 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000860 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000235 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0006954 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002064 ] ) ] . obo:CL_0000862 obo:IAO_0000115 "A macrophage that suppresses immune responses." ; a owl:Class ; rdfs:comment "Markers: May express: IL10, TGFbeta." ; rdfs:label "suppressor macrophage" ; rdfs:subClassOf obo:CL_0000861, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000861 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] ) ] . obo:CL_0000863 obo:IAO_0000115 "An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity." ; terms:description """Inflammatory macrophages, also sometimes referred to as M1 or classically activated macrophages, play an important role in the inflammatory response. The M1/M2 classification is based upon macrophage polarization rather than macrophage location and refers to macrophage activation towards either a more inflammatory or more resolving phenotype, respectively, although the functional diversity of macrophages is more nuanced than such a dichotomy suggests. Inflammatory macrophages are derived from monocytes recruited to a site of infection or injury. M1 macrophages are classically activated, typically by IFN-γ or lipopolysaccharide (LPS). Upon sensing signs of inflammation, they quickly respond by increasing their pro-inflammatory activity. They achieve this by producing a range of signaling molecules, such as nitric oxide, reactive oxygen species, and numerous cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1, -6 and -12. The release of these potent molecules helps to recruit other immune cells to the site, killing off pathogenic organisms and facilitation inflammation. At the same time, M1 macrophages can also present antigens to T cells, thereby helping to induce an adaptive immune response. Over time, these macrophages may transition in phenotype and function to help resolve the inflammation and promote tissue repair. Despite the beneficial role of inflammatory macrophages in dealing with pathogens, chronic activation of these cells can lead to harmful effects. Over time, continuous production of pro-inflammatory molecules can cause damage to tissues and organs. This is seen in certain chronic inflammatory diseases, such as atherosclerosis, diabetes, obesity, asthma, and various autoimmune disorders. In such situations, the normally protective function of inflammatory macrophages is not properly controlled, which can contribute to disease pathology. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasExactSynonym "classically activated macrophage" ; oboInOwl:hasRelatedSynonym "M1 macrophage" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response)." ; rdfs:label "inflammatory macrophage" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000863" ; rdfs:subClassOf obo:CL_0000861, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032611 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032635 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032640 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042554 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042742 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045428 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000861 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032611 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032635 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032640 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042554 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042742 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045428 ] ) ] . obo:CL_0000864 obo:IAO_0000115 "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." ; oboInOwl:hasDbXref "FMA:84642", "FMA:84644" ; oboInOwl:hasExactSynonym "fixed macrophage", "resting histiocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "tissue-resident macrophage" ; rdfs:subClassOf obo:CL_0000235, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000479 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000235 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000479 ] ) ] . obo:CL_0000865 obo:IAO_0000115 "A gut-associated lymphoid tissue macrophage found in lamina propria of the gut." ; oboInOwl:hasExactSynonym "gastrointestinal system (lamina propria) macrophage", "macrophage of gastrointestinal system (lamina propria)", "macrophage of gastrointestinal tract (lamina propria)" ; a owl:Class ; rdfs:label "gastrointestinal tract (lamina propria) macrophage" ; rdfs:subClassOf obo:CL_0000885, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004780 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000885 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004780 ] ) ] . obo:CL_0000866 obo:IAO_0000115 "A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Role or process: immune, clearance of apoptotic thymocytes, antigen-presentation." ; rdfs:label "thymic macrophage" ; rdfs:subClassOf obo:CL_0000864, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043277 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000864 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043277 ] ) ] . obo:CL_0000867 obo:IAO_0000115 "A tissue-resident macrophage found in a secondary lymphoid organ." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "secondary lymphoid organ macrophage" ; rdfs:subClassOf obo:CL_0000864 . obo:CL_0000868 obo:IAO_0000115 "A secondary lymphoid organ macrophage found in a lymph node. This cell is CD169-high." ; oboInOwl:hasExactSynonym "MF.LN" ; a owl:Class ; rdfs:comment "Marker was observed on rat cells." ; rdfs:label "lymph node macrophage" ; rdfs:subClassOf obo:CL_0000867, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001931 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001813 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000867 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001931 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001813 ] ) ] . obo:CL_0000869 obo:IAO_0000115 "A gut-associated lymphoid tissue macrophage found in tonsils." ; a owl:Class ; rdfs:label "tonsillar macrophage" ; rdfs:subClassOf obo:CL_0000885, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002372 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002395 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000884 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002372 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002395 ] ) ] . obo:CL_0000870 obo:IAO_0000115 "A gut-associated lymphoid tissue macrophage found in the Peyer's patches." ; a owl:Class ; rdfs:label "Peyer's patch macrophage" ; rdfs:subClassOf obo:CL_0000885, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001211 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000885 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001211 ] ) ] . obo:CL_0000871 obo:IAO_0000115 "A secondary lymphoid organ macrophage found in the spleen." ; oboInOwl:hasDbXref "FMA:83026" ; a owl:Class ; rdfs:comment "Role or process: immune, clearance of apoptotic and senescent cells." ; rdfs:label "splenic macrophage" ; rdfs:subClassOf obo:CL_0000867, obo:CL_2000074, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0034102 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000867 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0034102 ] ) ] . obo:CL_0000872 obo:IAO_0000115 "A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Markers: Mouse: F4/80-, MARCO+, SR-A+, SIGN-R1+, Dectin2+." ; rdfs:label "splenic marginal zone macrophage" ; rdfs:subClassOf obo:CL_0000871, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001251 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001806 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001884 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001885 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000006172 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000871 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001251 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001806 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001884 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001885 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000006172 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-red-pulp/v1.2/assets/2d-ftu-spleen-red-pulp.png" . obo:CL_0000873 obo:IAO_0000115 "A splenic macrophage found in the areas surrounding the white pulp of the spleen, adjacent to the marginal sinus. Markers include F4/80-negative, Dectin2-low, sialoadhesin-positive." ; a owl:Class ; rdfs:comment "Markers: Mouse: F4/80-, Dectin2-low, sialoadhesin+." ; rdfs:label "splenic metallophillic macrophage" ; rdfs:subClassOf obo:CL_0000871, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001251 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001813 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001931 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001959 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001806 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000871 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001251 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001931 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001959 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001806 ] ) ] . obo:CL_0000874 obo:IAO_0000115 "A splenic macrophage found in the red-pulp of the spleen, and involved in immune responses to blood-borne pathogens and in the clearance of senescent erythrocytes. Markers include F4/80-positive, CD68-positive, MR-positive, Dectin2-positive, macrosialin-positive, and sialoadhesin-low." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Markers: Mouse: F4/80+, CD68+, MR+, Dectin2+, macrosialin+, sialoadhesin-low; role or process: immune, clearance of senescent erythrocytes." ; rdfs:label "splenic red pulp macrophage" ; rdfs:subClassOf obo:CL_0000871, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001250 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001013 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001806 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002064 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002972 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006955 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001931 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000871 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001250 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001806 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002064 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002972 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006955 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0034102 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001931 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-red-pulp/v1.2/assets/2d-ftu-spleen-red-pulp.png" . obo:CL_0000875 obo:IAO_0000115 "A type of monocyte characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, and decrease size relative to classical monocytes, but increased co-stimulatory activity. May also play a role in tissue repair." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "patrolling monocyte", "resident monocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Markers: CCR2-CX3CCR1+ (human, mouse, rat); human: CD16+, CCR5+, CD32/FcgRII-high, MHCII+, CD86+; mouse: CD62L-Ly6C-." ; rdfs:label "non-classical monocyte" ; rdfs:subClassOf obo:CL_0000576, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000587 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002393 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0031294 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030224 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001206 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000576 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000587 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0031294 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030224 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001206 ] ) ] . obo:CL_0000876 obo:IAO_0000115 "A splenic macrophage found in the white pulp of the spleen. Markers include F4/80-negative, CD68-positive, and macrosialin-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Markers: Mouse: F4/80-, CD68+, macrosialin+." ; rdfs:label "splenic white pulp macrophage" ; rdfs:subClassOf obo:CL_0000871, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001959 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001813 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002064 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000871 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001959 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002064 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-white-pulp/v1.2/assets/2d-ftu-spleen-white-pulp.png" . obo:CL_0000877 obo:IAO_0000115 "A splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centers. A marker for a cell of this type is Mertk-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "splenic tingible body macrophage" ; rdfs:subClassOf obo:CL_0000876, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001249 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000010329 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043277 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000876 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001249 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000010329 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043277 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-red-pulp/v1.2/assets/2d-ftu-spleen-red-pulp.png" . obo:CL_0000878 obo:IAO_0000115 "A tissue-resident macrophage found in the central nervous system." ; terms:description """Central Nervous System (CNS) macrophages represent an integral part of the brain's innate immune system. These immune cells play crucial roles in maintenance and regulation, homeostasis, and disease response, thereby helping in the overall cognitive functioning of an organism. There are different macrophage populations in the CNS, often classified into microglial cells, which reside in the parenchyma, and non-parenchymal macrophages at the interface between the brain and the periphery, including the perivascular spaces, the choroid plexus, and the meninges. CNS macrophages are derived from erythromyeloid progenitors in the yolk sac. CNS macrophages have distinct morphologies: Meningeal and perivascular macrophages have a more elongated shape than microglia, which are characterized by a small cell body with fine processes; in contrast, choroid plexus macrophages typically have a stellate shape. Microglia are the most abundant abundant mononuclear phagocytes and have been shown to play a number of physiological roles, including proinflammatory and anti-inflammatory functions, synaptic pruning and remodeling, and apoptotic cell removal through phagocytosis. Non-parenchymal CAMs primarily support the barrier function against external antigens. Meningeal macrophages have been shown to respond to peripheral microbial challenges and to protect the brain against fatal viral infection. CNS macrophages are also involved in the initiation and progression of many neurological diseases, such as Alzheimer's disease and Parkinson's disease as well as multiple sclerosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasExactSynonym "CNS macrophage" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "central nervous system macrophage" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000878" ; rdfs:subClassOf obo:CL_0000864, obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000864 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] . obo:CL_0000879 obo:IAO_0000115 "A border associated macrophage that is part of a meninx. This macrophage type is elongated and amoeboid spindle-shaped with limited mobility. This macrophage is highly phagocytic, expresses scavenger receptors, has dynamic protrusions and extends its processes during inflammation." ; oboInOwl:hasExactSynonym "subdural leptomeningeal macrophage", "subdural meningeal macrophage" ; oboInOwl:hasRelatedSynonym "MM", "MnMΦ", "sdΜΦ" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "meningeal macrophage" ; rdfs:subClassOf obo:CL_4042003, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002360 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0005044 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4042003 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002360 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0005044 ] ) ] . obo:CL_0000880 obo:IAO_0000115 "A border associated macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This central nervous system macrophage has a star-like shaped body and expresses scavenger receptors." ; oboInOwl:hasRelatedSynonym "cpMΦ" ; a owl:Class ; rdfs:label "choroid plexus macrophage" ; rdfs:subClassOf obo:CL_4042003, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001886 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0005044 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4042003 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001886 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0005044 ] ) ] . obo:CL_0000881 obo:IAO_0000115 "A border associated macrophage that is adjacent to a small blood vessel of a brain. A perivascular macrophage expresses the markers CD14, CD16 and CD163. In homeostatic conditions, this central nervous system macrophage has a non-motile cell body with extending and retracting projections through the blood vessel wall." ; oboInOwl:hasRelatedSynonym "pvMΦ" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "perivascular macrophage" ; rdfs:subClassOf obo:CL_4033054, obo:CL_4042003, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001889 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001925 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4042003 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001925 ] ) ] . obo:CL_0000882 obo:IAO_0000115 "A thymic macrophage found in the thymic medulla." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "thymic medullary macrophage" ; rdfs:subClassOf obo:CL_0000866, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002124 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000866 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002124 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" . obo:CL_0000883 obo:IAO_0000115 "A thymic macrophage found in the thymic cortex." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "thymic cortical macrophage" ; rdfs:subClassOf obo:CL_0000866, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002123 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000866 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002123 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" . obo:CL_0000884 obo:IAO_0000115 "A tissue-resident macrophage found in the mucosa associated lymphoid tissue." ; a owl:Class ; rdfs:label "mucosa-associated lymphoid tissue macrophage" ; rdfs:subClassOf obo:CL_0000867, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001961 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000867 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001961 ] ) ] . obo:CL_0000885 obo:IAO_0000115 "A mucosa-associated lymphoid tissue macrophage found in the mucosa-associated lymphoid tissues of the gut." ; a owl:Class ; rdfs:label "gut-associated lymphoid tissue macrophage" ; rdfs:subClassOf obo:CL_0000884, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001962 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002387 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000884 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001962 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002387 ] ) ] . obo:CL_0000886 obo:IAO_0000115 "A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues." ; a owl:Class ; rdfs:label "nasal and broncial associated lymphoid tissue macrophage" ; rdfs:subClassOf obo:CL_0000884, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001963 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002395 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000884 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001963 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002395 ] ) ] . obo:CL_0000887 obo:IAO_0000115 "A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens. This macrophage is capable of activating invaraint NKT cells and is CD169-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lymph node subcapsular sinus macrophage" ; rdfs:subClassOf obo:CL_0000868, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032816 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002194 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000868 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001931 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032816 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002194 ] ) ] . obo:CL_0000888 obo:IAO_0000115 "A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lymph node tingible body macrophage" ; rdfs:subClassOf obo:CL_0000868, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002006 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002905 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043277 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000868 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002006 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002905 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043277 ] ) ] . obo:CL_0000889 obo:IAO_0000115 "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis." ; rdfs:label "myeloid suppressor cell" ; rdfs:subClassOf obo:CL_0000766, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001501 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000766 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001501 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] ) ] . obo:CL_0000890 obo:IAO_0000115 "An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling." ; terms:description """Alternatively activated macrophages, also referred to as M2 macrophages, are immune cells originating from monocytes. The M1/M2 classification is based upon macrophage polarization rather than macrophage location and refers to macrophage activation towards either a more inflammatory or more resolving phenotype, respectively, although the functional diversity of macrophages is more nuanced than such a dichotomy suggests. M2 macrophages cells are differentiated from their precursors generally in response to Th2 cytokines, such as interleukin-4 (IL-4), interleukin-10 (IL-10), and interleukin-13 (IL-13). Tissue-resident macrophages are also sometimes said to have an “M2-like” phenotype. M2 macrophages play key roles in immunoregulation and disease resolution. Functionally, alternatively activated macrophages are essential in wound healing and tissue repair and remodeling, largely due to their potent anti-inflammatory actions and their ability to promote angiogenesis. They achieve these functions by the production of specific growth factors and signaling proteins including Arg1, Ym1/2, Fizz1, and TGF-β. Additionally, they provide defense against specific categories of pathogens, particularly parasites, through specific communication with Th2 cells. However, dysfunction of M2 macrophages can be harmful. Alternatively activated macrophages have been associated with several pathological conditions such as asthma, fibrosis, and tumor progression. This is due to their capacity to inhibit inflammatory responses, promote unneeded wound healing processes, and support tumour growth and spreading. Furthermore, complex roles have been observed in metabolic disorders, cardiovascular diseases, and neurodegenerative diseases, showing the diverse functional spectrum of these cells. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasRelatedSynonym "M2 macrophage" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Role or process: tissue remodeling." ; rdfs:label "alternatively activated macrophage" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000890" ; rdfs:subClassOf obo:CL_0000861, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001844 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048771 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000861 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001844 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048771 ] ) ] . obo:CL_0000891 obo:IAO_0000115 "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." ; oboInOwl:hasDbXref "BTO:0003872", "FMA:83586", "MESH:D005487" ; a owl:Class ; rdfs:label "foam cell" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0000892 obo:IAO_0000115 "A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." ; a owl:Class ; rdfs:label "smooth muscle cell derived foam cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000255, obo:CL_0000891, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000192 ] . obo:CL_0000893 obo:IAO_0000115 "An immature T cell located in the thymus." ; oboInOwl:hasBroadSynonym "immature T cell", "immature T lymphocyte", "immature T-cell", "immature T-lymphocyte" ; oboInOwl:hasDbXref "BTO:0001372", "CALOHA:TS-1042", "FMA:72202", "MESH:D060168", "XAO:0003159" ; oboInOwl:hasExactSynonym "thymic lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "thymocyte" ; rdfs:subClassOf obo:CL_0002420, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0045058 ] ) ] . obo:CL_0000894 obo:IAO_0000115 "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative." ; oboInOwl:hasExactSynonym "DN1 thymic pro-T lymphocyte", "DN1 thymic pro-T-cell", "DN1 thymic pro-T-lymphocyte", "DN1 thymic progenitor T cell", "DN1 thymocyte", "double negative 1", "preT.DN1.Th" ; a owl:Class ; rdfs:label "DN1 thymic pro-T cell" ; rdfs:subClassOf obo:CL_0000827, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002425 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000827 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ] ) ] . obo:CL_0000895 obo:IAO_0000115 "An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "naive CD4+ T cell" ; oboInOwl:hasExactSynonym "T.4Nve.Sp", "Th0", "naive thymus-derived CD4-positive, alpha-beta T lymphocyte", "naive thymus-derived CD4-positive, alpha-beta T-cell", "naive thymus-derived CD4-positive, alpha-beta T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD4+ T cell', but includes additional markers known to be expressed on naive CD4+ T cells." ; rdfs:label "naive thymus-derived CD4-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000624, obo:CL_0000898, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002436 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001307 ] ) ] . obo:CL_0000896 obo:IAO_0000115 "A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." ; oboInOwl:hasExactSynonym "activated CD4-positive, alpha-beta T lymphocyte", "activated CD4-positive, alpha-beta T-cell", "activated CD4-positive, alpha-beta T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "activated CD4-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000624, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001318 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000895 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] ) ] . obo:CL_0000897 obo:IAO_0000115 "A CD4-positive, alpha-beta T cell that has differentiated into a memory T cell." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasExactSynonym "CD4-positive, alpha-beta memory T lymphocyte", "CD4-positive, alpha-beta memory T-cell", "CD4-positive, alpha-beta memory T-lymphocyte" ; oboInOwl:hasRelatedSynonym "T4.Mem.Sp" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "CD4-positive, alpha-beta memory T cell" ; rdfs:subClassOf obo:CL_0000624, obo:CL_0000813 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001603 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0002286 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0043379 ] ) ] . obo:CL_0000898 obo:IAO_0000115 "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." ; oboInOwl:hasExactSynonym "naive T lymphocyte", "naive T-cell", "naive T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "naive T cell" ; rdfs:subClassOf obo:CL_0002419, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001203 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001318 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001307 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002419 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0045058 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001307 ] ) ] . obo:CL_0000899 obo:IAO_0000115 "CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "MESH:D058504" ; oboInOwl:hasExactSynonym "IL-17-producing CD4+ T helper", "T helper cells type 17", "T(H)-17 cell", "Th17 CD4+ T cell", "Th17 T cell", "Th17 T lymphocyte", "Th17 T-cell", "Th17 T-lymphocyte", "Th17 cell", "helper T cell type 17" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'Th17 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 17 T cells." ; rdfs:label "T-helper 17 cell" ; rdfs:subClassOf obo:CL_0000492, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003455 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001207 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001202 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032620 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000492 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003455 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001207 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001202 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032620 ] ) ] . obo:CL_0000900 obo:IAO_0000115 "A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "naive CD8+ T cell" ; oboInOwl:hasExactSynonym "naive thymus-dervied CD8-positive, alpha-beta T lymphocyte", "naive thymus-dervied CD8-positive, alpha-beta T-cell", "naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte" ; oboInOwl:hasNarrowSynonym "T.8Nve.Sp" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell traffics in secondary lymphoid organs and blood. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD8+ T cell', but includes additional markers known to be expressed on naive CD8+ T cells." ; rdfs:label "naive thymus-derived CD8-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000625, obo:CL_0000898, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002437 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000625 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001307 ] ) ] . obo:CL_0000901 obo:IAO_0000115 "CD4-positive alpha-beta T cell with regulatory function that produces IL-10." ; oboInOwl:hasExactSynonym "T-regulatory T cell type 1", "Tr1 T cell", "Tr1 T lymphocyte", "Tr1 T-cell", "Tr1 T-lymphocyte" ; a owl:Class ; rdfs:comment "These cells are reportedly induced by IL-10 and are capable of producing IFN-gamma, IL-5, IL-10, and TGF-beta.)" ; rdfs:label "Tr1 cell" ; rdfs:subClassOf obo:CL_0000492, obo:CL_0000815, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032613 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] ) ] . obo:CL_0000902 obo:IAO_0000115 "CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function." ; oboInOwl:hasExactSynonym "iTreg", "induced Treg", "induced regulatory T cell", "induced regulatory T lymphocyte", "induced regulatory T-cell", "induced regulatory T-lymphocyte" ; oboInOwl:hasRelatedSynonym "aTreg", "adaptive Treg" ; a owl:Class ; rdfs:label "induced T-regulatory cell" ; rdfs:subClassOf obo:CL_0000792, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001350 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001852 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000896 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000792 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001350 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001852 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000896 ] ) ] . obo:CL_0000903 obo:IAO_0000115 "CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function." ; oboInOwl:hasExactSynonym "nTreg", "natural Treg", "natural regulatory T cell", "natural regulatory T lymphocyte", "natural regulatory T-cell", "natural regulatory T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "natural T-regulatory cell" ; rdfs:subClassOf obo:CL_0000792, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001350 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001318 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001852 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000809 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000792 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001350 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001852 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000809 ] ) ] . obo:CL_0000904 obo:IAO_0000115 "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; oboInOwl:hasBroadSynonym "central memory CD4+ T cell" ; oboInOwl:hasExactSynonym "central CD4-positive, alpha-beta memory T cell", "central CD4-positive, alpha-beta memory T lymphocyte", "central CD4-positive, alpha-beta memory T-cell", "central CD4-positive, alpha-beta memory T-lymphocyte", "central memory CD4-positive, alpha-beta T lymphocyte", "central memory CD4-positive, alpha-beta T-cell", "central memory CD4-positive, alpha-beta T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD4+ T cell', but includes additional markers known to be expressed on central memory CD4+ T cells." ; rdfs:label "central memory CD4-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0001204, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001203 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001204 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001203 ] ) ] . obo:CL_0000905 obo:IAO_0000115 "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "effector memory CD4+ T cell" ; oboInOwl:hasExactSynonym "effector CD4-positive, alpha-beta memory T cell", "effector CD4-positive, alpha-beta memory T lymphocyte", "effector CD4-positive, alpha-beta memory T-cell", "effector CD4-positive, alpha-beta memory T-lymphocyte", "effector memory CD4-positive, alpha-beta T lymphocyte", "effector memory CD4-positive, alpha-beta T-cell", "effector memory CD4-positive, alpha-beta T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD4+ T cell', but includes additional markers known to be expressed on effector memory CD4+ T cells." ; rdfs:label "effector memory CD4-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0001204, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001204 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] ) ] . obo:CL_0000906 obo:IAO_0000115 "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative." ; oboInOwl:hasExactSynonym "activated CD8-positive, alpha-beta T lymphocyte", "activated CD8-positive, alpha-beta T-cell", "activated CD8-positive, alpha-beta T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "activated CD8-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000625, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001318 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000900 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000625 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] ) ] . obo:CL_0000907 obo:IAO_0000115 "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; oboInOwl:hasBroadSynonym "central memory CD8+ T cell" ; oboInOwl:hasExactSynonym "central CD8-positive, alpha-beta memory T cell", "central CD8-positive, alpha-beta memory T lymphocyte", "central CD8-positive, alpha-beta memory T-cell", "central CD8-positive, alpha-beta memory T-lymphocyte", "central memory CD8-positive, alpha-beta T lymphocyte", "central memory CD8-positive, alpha-beta T-cell", "central memory CD8-positive, alpha-beta T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD8+ T cell', but includes additional markers known to be expressed on central memory CD8+ T cells." ; rdfs:label "central memory CD8-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0001203, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001203 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001203 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001203 ] ) ] . obo:CL_0000908 obo:IAO_0000115 "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines." ; oboInOwl:hasExactSynonym "CD8-positive, alpha-beta cytokine secreting effector T lymphocyte", "CD8-positive, alpha-beta cytokine secreting effector T-cell", "CD8-positive, alpha-beta cytokine secreting effector T-lymphocyte" ; a owl:Class ; rdfs:label "CD8-positive, alpha-beta cytokine secreting effector T cell" ; rdfs:subClassOf obo:CL_0000625, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001318 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000906 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000625 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ) ] . obo:CL_0000909 obo:IAO_0000115 "A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasExactSynonym "CD8-positive, alpha-beta memory T lymphocyte", "CD8-positive, alpha-beta memory T-cell", "CD8-positive, alpha-beta memory T-lymphocyte" ; oboInOwl:hasRelatedSynonym "T.8Mem.Sp" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "CD8-positive, alpha-beta memory T cell" ; rdfs:subClassOf obo:CL_0000625, obo:CL_0000813 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000625 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001603 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0002286 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0043379 ] ) ] . obo:CL_0000910 obo:IAO_0000115 "A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000289", "CALOHA:TS-0190", "FMA:70573" ; oboInOwl:hasExactSynonym "cytotoxic T lymphocyte", "cytotoxic T-cell", "cytotoxic T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "cytotoxic T cell" ; rdfs:subClassOf obo:CL_0000911, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001913 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001913 ] ) ] . obo:CL_0000911 obo:IAO_0000115 "A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response." ; oboInOwl:hasExactSynonym "effector T lymphocyte", "effector T-cell", "effector T-lymphocyte" ; a owl:Class ; rdfs:label "effector T cell" ; rdfs:subClassOf obo:CL_0002419, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0045026 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002419 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0045026 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0045058 ] ) ] . obo:CL_0000912 obo:IAO_0000115 "A effector T cell that provides help in the form of secreted cytokines to other immune cells." ; oboInOwl:hasDbXref "BTO:0002417", "MESH:D006377" ; oboInOwl:hasExactSynonym "T-helper cell", "helper T lymphocyte", "helper T-cell", "helper T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "helper T cell" ; rdfs:subClassOf obo:CL_0000911, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] ) ] . obo:CL_0000913 obo:IAO_0000115 "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "effector memory CD8+ T cell" ; oboInOwl:hasExactSynonym "effector CD8-positive, alpha-beta memory T cell", "effector CD8-positive, alpha-beta memory T lymphocyte", "effector CD8-positive, alpha-beta memory T-cell", "effector CD8-positive, alpha-beta memory T-lymphocyte", "effector memory CD8-positive, alpha-beta T lymphocyte", "effector memory CD8-positive, alpha-beta T-cell", "effector memory CD8-positive, alpha-beta T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD8+ T cell', but includes additional markers known to be expressed on effector memory CD8+ T cells." ; rdfs:label "effector memory CD8-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0001203, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001203 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] ) ] . obo:CL_0000914 obo:IAO_0000115 "An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "immature NK T lymphocyte", "immature NK T-cell", "immature NK T-lymphocyte", "immature NKT cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "immature NK T cell" ; rdfs:subClassOf obo:CL_0000790, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003469 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000809 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000790 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003469 ] ) ] . obo:CL_0000915 obo:IAO_0000115 "An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "CD8-alpha-alpha-positive, alpha-beta intraepithelial T lymphocyte", "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-cell", "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell" ; rdfs:subClassOf obo:CL_0000797, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000811 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000797 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001084 ] ) ] . obo:CL_0000916 obo:IAO_0000115 "A mature gamma-delta T cell located in the epidermis that regulates wound healing." ; oboInOwl:hasExactSynonym "DETC", "dendritic epidermal T lymphocyte", "dendritic epidermal T-cell", "dendritic epidermal T-lymphocyte" ; a owl:Class ; rdfs:comment "In mice, DETC have an invariant T cell receptor." ; rdfs:label "dendritic epidermal T cell" ; rdfs:subClassOf obo:CL_0000800, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002401 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0060054 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000800 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0060054 ] ) ] . obo:CL_0000917 obo:IAO_0000115 "A CD8-positive, alpha-beta positive T cell that has the phenotype T-bet-positive, eomesodermin-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." ; oboInOwl:hasDbXref "BTO:0004793", "BTO:0004888", "FMA:84793" ; oboInOwl:hasExactSynonym "CD8-positive Th1 cell", "T-cytotoxic T cell type 1", "Tc1 CD8+ T cell", "Tc1 T cell", "Tc1 T lymphocyte", "Tc1 T-cell", "Tc1 T-lymphocyte", "Th1 CD8-positive T cell", "Th1 non-TFH CD8-positive T cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'Tc1 CD8+ T cell', but its logical definition includes additional known characteristics of Tc1 T cells." ; rdfs:label "Tc1 cell" ; rdfs:subClassOf obo:CL_0000908, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001835 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003463 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001202 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001207 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000908 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001835 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003463 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001202 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001207 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] ) ] . obo:CL_0000918 obo:IAO_0000115 "A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4." ; oboInOwl:hasDbXref "BTO:0004794", "FMA:84794" ; oboInOwl:hasExactSynonym "CD8-positive Th2 cell", "T-cytotoxic T cell type 2", "Tc2 T cell", "Tc2 T lymphocyte", "Tc2 T-cell", "Tc2 T-lymphocyte", "Th2 CD8-positive T cell", "Th2 non-TFH CD8-positive T cell" ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell' (see CL:0001052), but includes the additional necessary and sufficient conditions to allow classification as a Tc2 T cell." ; rdfs:label "Tc2 cell" ; rdfs:subClassOf obo:CL_0000908, obo:CL_0001052, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001941 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032633 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000908 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001941 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001202 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001207 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032633 ] ) ] . obo:CL_0000919 obo:IAO_0000115 "A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function." ; oboInOwl:hasExactSynonym "CD8+CD25+ T cell", "CD8+CD25+ T lymphocyte", "CD8+CD25+ T(reg)", "CD8+CD25+ T-cell", "CD8+CD25+ T-lymphocyte", "CD8+CD25+ Treg", "CD8-positive, CD25-positive Treg", "CD8-positive, CD25-positive, alpha-beta regulatory T lymphocyte", "CD8-positive, CD25-positive, alpha-beta regulatory T-cell", "CD8-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" ; a owl:Class ; rdfs:label "CD8-positive, CD25-positive, alpha-beta regulatory T cell" ; rdfs:subClassOf obo:CL_0000795, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001350 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000906 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000795 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001350 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] ) ] . obo:CL_0000920 obo:IAO_0000115 "CD8-positive, alpha-beta positive regulatory T cell with the phenotype CD28-negative and FoxP3-positive." ; oboInOwl:hasExactSynonym "CD8+CD28- T cell", "CD8+CD28- T lymphocyte", "CD8+CD28- T(reg)", "CD8+CD28- T-cell", "CD8+CD28- T-lymphocyte", "CD8+CD28- Treg", "CD8-positive, CD28-negative T(reg)", "CD8-positive, CD28-negative Treg", "CD8-positive, CD28-negative, alpha-beta regulatory T lymphocyte", "CD8-positive, CD28-negative, alpha-beta regulatory T-cell", "CD8-positive, CD28-negative, alpha-beta regulatory T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "CD8-positive, CD28-negative, alpha-beta regulatory T cell" ; rdfs:subClassOf obo:CL_0000795, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001350 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001841 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000906 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000795 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001350 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001841 ] ) ] . obo:CL_0000921 obo:IAO_0000115 "An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "classical NK T cell", "type I NK T lymphocyte", "type I NK T-cell", "type I NK T-lymphocyte", "type I NKT cell" ; oboInOwl:hasRelatedSynonym "invariant NK T cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "In mouse the canonical TCR is V-alpha-14, and in humans it is V-alpha 24." ; rdfs:label "type I NK T cell" ; rdfs:subClassOf obo:CL_0000814, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043208 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000814 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043208 ] ) ] . obo:CL_0000922 obo:IAO_0000115 "An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d." ; oboInOwl:hasExactSynonym "type II NK T lymphocyte", "type II NK T-cell", "type II NK T-lymphocyte", "type II NKT cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type II NK T cell" ; rdfs:subClassOf obo:CL_0000814, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002288 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000814 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002288 ] ) ] . obo:CL_0000923 obo:IAO_0000115 "A type I NK T cell that has the phenotype CD4-positive." ; oboInOwl:hasExactSynonym "CD4-positive type I NK T lymphocyte", "CD4-positive type I NK T-cell", "CD4-positive type I NK T-lymphocyte", "CD4-positive type I NKT cell" ; oboInOwl:hasNarrowSynonym "NKT.4+.SP" ; a owl:Class ; rdfs:label "CD4-positive type I NK T cell" ; rdfs:subClassOf obo:CL_0000921, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000921 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] ) ] . obo:CL_0000924 obo:IAO_0000115 "A type I NK T cell that has the phenotype CD4-negative and CD8-negative." ; oboInOwl:hasExactSynonym "CD4-negative, CD8-negative type I NK T lymphocyte", "CD4-negative, CD8-negative type I NK T-cell", "CD4-negative, CD8-negative type I NK T-lymphocyte", "CD4-negative, CD8-negative type I NKT cell" ; oboInOwl:hasNarrowSynonym "NKT.4-.Sp" ; a owl:Class ; rdfs:label "CD4-negative, CD8-negative type I NK T cell" ; rdfs:subClassOf obo:CL_0000921, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000921 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] ) ] . obo:CL_0000925 obo:IAO_0000115 "A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers." ; oboInOwl:hasExactSynonym "activated CD4-positive type I NK T lymphocyte", "activated CD4-positive type I NK T-cell", "activated CD4-positive type I NK T-lymphocyte", "activated CD4-positive type I NKT cell" ; a owl:Class ; rdfs:label "activated CD4-positive type I NK T cell" ; rdfs:subClassOf obo:CL_0000923, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032633 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000921 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032633 ] ) ] . obo:CL_0000926 obo:IAO_0000115 "A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses." ; oboInOwl:hasExactSynonym "CD4-positive type I NK T cell secreting IFN-gamma", "CD4-positive type I NK T lymphocyte secreting interferon-gamma", "CD4-positive type I NK T-cell secreting interferon-gamma", "CD4-positive type I NK T-lymphocyte secreting interferon-gamma", "CD4-positive type I NKT cell secreting interferon-gamma" ; a owl:Class ; rdfs:label "CD4-positive type I NK T cell secreting interferon-gamma" ; rdfs:subClassOf obo:CL_0000923, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000925 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002827 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000921 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002827 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] ) ] . obo:CL_0000927 obo:IAO_0000115 "A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses." ; oboInOwl:hasExactSynonym "CD4-positive type I NK T cell secreting IL-4", "CD4-positive type I NK T lymphocyte secreting interleukin-4", "CD4-positive type I NK T-cell secreting interleukin-4", "CD4-positive type I NK T-lymphocyte secreting interleukin-4", "CD4-positive type I NKT cell secreting interleukin-4" ; a owl:Class ; rdfs:label "CD4-positive type I NK T cell secreting interleukin-4" ; rdfs:subClassOf obo:CL_0000923, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000925 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002830 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032616 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032633 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000921 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002830 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032616 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032633 ] ) ] . obo:CL_0000928 obo:IAO_0000115 "A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers." ; oboInOwl:hasExactSynonym "activated CD4-negative, CD8-negative type I NK T lymphocyte", "activated CD4-negative, CD8-negative type I NK T-cell", "activated CD4-negative, CD8-negative type I NK T-lymphocyte", "activated CD4-negative, CD8-negative type I NKT cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "activated CD4-negative, CD8-negative type I NK T cell" ; rdfs:subClassOf obo:CL_0000924, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002369 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000921 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002369 ] ) ] . obo:CL_0000929 obo:IAO_0000115 "A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses." ; oboInOwl:hasExactSynonym "CD4-negative, CD8-negative type I NK T cell secreting IFN-gamma", "CD4-negative, CD8-negative type I NK T lymphocyte secreting interferon-gamma", "CD4-negative, CD8-negative type I NK T-cell secreting interferon-gamma", "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interferon-gamma", "CD4-negative, CD8-negative type I NKT cell secreting interferon-gamma" ; a owl:Class ; rdfs:label "CD4-negative, CD8-negative type I NK T cell secreting interferon-gamma" ; rdfs:subClassOf obo:CL_0000924, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000928 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002827 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000921 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002827 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] ) ] . obo:CL_0000930 obo:IAO_0000115 "A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses." ; oboInOwl:hasExactSynonym "CD4-negative, CD8-negative type I NK T cell secreting IL-4", "CD4-negative, CD8-negative type I NK T lymphocyte secreting interleukin-4", "CD4-negative, CD8-negative type I NK T-cell secreting interleukin-4", "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interleukin-4", "CD4-negative, CD8-negative type I NKT cell secreting interleukin-4" ; a owl:Class ; rdfs:label "CD4-negative, CD8-negative type I NK T cell secreting interleukin-4" ; rdfs:subClassOf obo:CL_0000924, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000928 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002830 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032633 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000921 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002830 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032633 ] ) ] . obo:CL_0000931 obo:IAO_0000115 "A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." ; oboInOwl:hasExactSynonym "activated type II NK T lymphocyte", "activated type II NK T-cell", "activated type II NK T-lymphocyte", "activated type II NKT cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "activated type II NK T cell" ; rdfs:subClassOf obo:CL_0000922, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002369 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000922 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002369 ] ) ] . obo:CL_0000932 obo:IAO_0000115 "A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers." ; oboInOwl:hasExactSynonym "type II NK T cell secreting IFN-gamma", "type II NK T lymphocyte secreting interferon-gamma", "type II NK T-cell secreting interferon-gamma", "type II NK T-lymphocyte secreting interferon-gamma", "type II NKT cell secreting interferon-gamma" ; a owl:Class ; rdfs:label "type II NK T cell secreting interferon-gamma" ; rdfs:subClassOf obo:CL_0000922, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000931 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000922 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] ) ] . obo:CL_0000933 obo:IAO_0000115 "A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." ; oboInOwl:hasExactSynonym "type II NK T cell secreting IL-4", "type II NK T lymphocyte secreting interleukin-4", "type II NK T-cell secreting interleukin-4", "type II NK T-lymphocyte secreting interleukin-4", "type II NKT cell secreting interleukin-4" ; a owl:Class ; rdfs:label "type II NK T cell secreting interleukin-4" ; rdfs:subClassOf obo:CL_0000922, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000931 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032633 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000922 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032633 ] ) ] . obo:CL_0000934 obo:IAO_0000115 "A CD4-positive, alpha-beta T cell that has cytotoxic function." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "CD4-positive, alpha-beta cytotoxic T lymphocyte", "CD4-positive, alpha-beta cytotoxic T-cell", "CD4-positive, alpha-beta cytotoxic T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "CD4-positive, alpha-beta cytotoxic T cell" ; rdfs:subClassOf obo:CL_0000624, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000896 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001913 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001913 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ) ] . obo:CL_0000935 obo:IAO_0000115 "A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "CD4-negative, CD8-negative, alpha-beta intraepithelial T lymphocyte", "CD4-negative, CD8-negative, alpha-beta intraepithelial T-cell", "CD4-negative, CD8-negative, alpha-beta intraepithelial T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "CD4-negative, CD8-negative, alpha-beta intraepithelial T cell" ; rdfs:subClassOf obo:CL_0000797, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025403 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000797 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025403 ] ) ] . obo:CL_0000936 obo:IAO_0000115 "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "lymphoid-primed multipotent progenitor" ; oboInOwl:hasRelatedSynonym "ELP", "GMLP", "LMPP" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative." ; rdfs:label "early lymphoid progenitor" ; rdfs:subClassOf obo:CL_0000837, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001460 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002001 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002035 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030098 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000837 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030098 ] ) ] . obo:CL_0000937 obo:IAO_0000115 "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." ; oboInOwl:hasExactSynonym "pre-NK cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high." ; rdfs:label "pre-natural killer cell" ; rdfs:subClassOf obo:CL_0000623, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001381 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000623 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001381 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] ) ] . obo:CL_0000938 obo:IAO_0000115 "NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "CD16-CD56bright NK cell", "CD16-negative, CD56-bright NK cell", "CD56-bright cytokine secreting NK cell", "CD56-bright cytokine secreting natural killer cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'CD16-CD56bright NK cell'. Markers are associated with human cell types." ; rdfs:label "CD16-negative, CD56-bright natural killer cell, human" ; rdfs:subClassOf obo:CL_0000824, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001483 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001319 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001024 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000824 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001319 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001024 ] ) ] . obo:CL_0000939 obo:IAO_0000115 "A mature natural killer cell that has the phenotype CD56-low, CD16-positive and which is capable of cytotoxicity and cytokine production." ; oboInOwl:hasExactSynonym "CD16+CD56+ NK cell", "CD16-positive, CD56-dim NK cell", "CD16-positive, CD56-low NK cell", "CD16-positive, CD56-low natural killer cell", "CD16-positive, CD56-positive NK cell", "CD16-positive, CD56-positive natural killer cell", "cytotoxic CD56-dim NK cell", "cytotoxic CD56-dim natural killer cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'CD16+CD56+ NK cell'. Markers are associated with human cell types." ; rdfs:label "CD16-positive, CD56-dim natural killer cell, human" ; rdfs:subClassOf obo:CL_0000824, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042267 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001024 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000824 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042267 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001024 ] ) ] . obo:CL_0000940 obo:IAO_0000115 "An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "mucosal invariant T lymphocyte", "mucosal invariant T-cell", "mucosal invariant T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "mucosal invariant T cell" ; rdfs:subClassOf obo:CL_0000791, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002227 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032394 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000791 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002227 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032394 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ) ] . obo:CL_0000941 obo:IAO_0000115 "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative." ; a owl:Class ; rdfs:comment "In the mouse this cell expresses CD8-alpha-alpha." ; rdfs:label "thymic conventional dendritic cell" ; rdfs:subClassOf obo:CL_0000990, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000894 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001013 ] ) ] . obo:CL_0000942 obo:IAO_0000115 "A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "thymic plasmacytoid dendritic cell" ; rdfs:subClassOf obo:CL_0000784, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001865 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000894 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000784 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001865 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" . obo:CL_0000943 obo:IAO_0000115 "A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma." ; oboInOwl:hasExactSynonym "B effector 1 cell" ; oboInOwl:hasRelatedSynonym "B effector cell type 1" ; a owl:Class ; rdfs:comment "Be1 cells are also reportedly capable of secreting IL-6, IL-10, and IL-12. They are also reportedly CD11b-negative and B220-positive." ; rdfs:label "Be1 Cell" ; rdfs:subClassOf obo:CL_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032623 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032640 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045627 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000968 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032640 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045627 ] ) ] . obo:CL_0000944 obo:IAO_0000115 "A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6." ; oboInOwl:hasExactSynonym "B effector 2 cell" ; oboInOwl:hasRelatedSynonym "B effector cell type 2" ; a owl:Class ; rdfs:comment "Be2 cells are also reportedly capable of secreting IL-13 and TNF. They are also reportedly CD11b-negative and B220-positive." ; rdfs:label "Be2 cell" ; rdfs:subClassOf obo:CL_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032623 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032633 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032635 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045630 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000968 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032633 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032635 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045630 ] ) ] . obo:CL_0000945 obo:IAO_0000115 "A lymphocyte of B lineage with the commitment to express an immunoglobulin complex." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex)." ; rdfs:label "lymphocyte of B lineage" ; rdfs:subClassOf obo:CL_0000542, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000826 ] . obo:CL_0000946 obo:IAO_0000115 "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "antibody secreting cell" ; rdfs:subClassOf obo:CL_0000945, [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0042571 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000945 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0042571 ] ) ] . obo:CL_0000947 obo:IAO_0000115 "A long lived plasma cell that secretes IgE." ; a owl:Class ; rdfs:label "IgE plasma cell" ; rdfs:subClassOf obo:CL_0000974, [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071743 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000974 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071743 ] ) ] . obo:CL_0000948 obo:IAO_0000115 "A class switched memory B cell that expresses IgE on the cell surface." ; oboInOwl:hasExactSynonym "IgE memory B lymphocyte", "IgE memory B-cell", "IgE memory B-lymphocyte", "memory IgE B cell", "memory IgE B lymphocyte", "memory IgE B-cell", "memory IgE B-lymphocyte" ; a owl:Class ; rdfs:label "IgE memory B cell" ; rdfs:subClassOf obo:CL_0000972, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071742 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000972 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071742 ] ) ] . obo:CL_0000949 obo:IAO_0000115 "A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult." ; a owl:Class ; rdfs:label "IgD plasmablast" ; rdfs:subClassOf obo:CL_0000980, [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071739 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000980 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071739 ] ) ] . obo:CL_0000950 obo:IAO_0000115 "A plasmablast that secretes IgE." ; a owl:Class ; rdfs:label "IgE plasmablast" ; rdfs:subClassOf obo:CL_0000980, [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071743 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000980 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071743 ] ) ] . obo:CL_0000951 obo:IAO_0000115 "A short lived plasma cell that secretes IgE." ; a owl:Class ; rdfs:label "IgE short lived plasma cell" ; rdfs:subClassOf obo:CL_0000975, [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071743 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000975 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071743 ] ) ] . obo:CL_0000952 obo:IAO_0000115 "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." ; a owl:Class ; rdfs:label "preBCR-positive large pre-B-II cell" ; rdfs:subClassOf obo:CL_0000957, [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0071708 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0035369 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001858 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001859 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000957 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0071708 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0035369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001858 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001859 ] ) ] . obo:CL_0000953 obo:IAO_0000115 "A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes." ; a owl:Class ; rdfs:label "preBCR-negative large pre-B-II cell" ; rdfs:subClassOf obo:CL_0000957, [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0071708 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0035369 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001858 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001859 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000957 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0071708 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0035369 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001858 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001859 ] ) ] . obo:CL_0000954 obo:IAO_0000115 "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes." ; oboInOwl:hasExactSynonym "small pre-BII cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Small pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-negative, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive." ; rdfs:label "small pre-B-II cell" ; rdfs:subClassOf obo:CL_0000955, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003457 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003460 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0019815 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0035369 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0071708 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000955 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003457 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003460 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0019815 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0035369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0071708 ] ) ] . obo:CL_0000955 obo:IAO_0000115 "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain." ; oboInOwl:hasDbXref "BTO:0001133", "CALOHA:TS-0819" ; oboInOwl:hasExactSynonym "pre-B-lymphocyte", "pre-BII cell" ; a owl:Class ; rdfs:comment "pre-B-II cell are also reportedly CD19-positive, CD22-positive, CD38-positive, CD45-positive, and CD48-positive." ; rdfs:label "pre-B-II cell" ; rdfs:subClassOf obo:CL_0000817, [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000006611 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0071707 ] ; owl:disjointWith obo:CL_0000956 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000817 [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000006611 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0071707 ] ) ] . obo:CL_0000956 obo:IAO_0000115 "A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein." ; oboInOwl:hasExactSynonym "pre-BI cell" ; oboInOwl:hasRelatedSynonym "pro-B cell (Philadelphia nomenclature)" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Human pre-B-I cells are reportedly CD10-positive, CD19-positive, CD22-positive, CD38-positive, CD45-low, CD79a-positive, CD127-negative, pre-BCR-negative, IgM-negative, IgD-negative, and Tdt-positive. Transcription factors expressed: Pax5-positive." ; rdfs:label "pre-B-I cell" ; rdfs:subClassOf obo:CL_0000817, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003457 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003460 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000006611 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0071707 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001858 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001859 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000817 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003457 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003460 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000006611 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0071707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001858 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001859 ] ) ] . obo:CL_0000957 obo:IAO_0000115 "A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative." ; oboInOwl:hasBroadSynonym "large pre-B cell" ; oboInOwl:hasExactSynonym "large pre-BII cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Large pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-positive, pre-BCR-positive, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive." ; rdfs:label "large pre-B-II cell" ; rdfs:subClassOf obo:CL_0000955, [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000003457 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000003460 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0046651 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000955 [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000003457 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000003460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0046651 ] ) ] . obo:CL_0000958 obo:IAO_0000115 "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative." ; oboInOwl:hasExactSynonym "T1 B lymphocyte", "T1 B-cell", "T1 B-lymphocyte", "transitional stage 1 B cell" ; a owl:Class ; rdfs:comment "T1 B cells are also reportedly CD10-negative/positive??, CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive." ; rdfs:label "T1 B cell" ; rdfs:subClassOf obo:CL_0000818, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001318 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001338 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001880 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000818 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001338 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001880 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] ) ] . obo:CL_0000959 obo:IAO_0000115 "A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive." ; oboInOwl:hasExactSynonym "T2 B lymphocyte", "T2 B-cell", "T2 B-lymphocyte", "transitional stage 2 B cell" ; a owl:Class ; rdfs:comment "T2 B cells are also reportedly CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive." ; rdfs:label "T2 B cell" ; rdfs:subClassOf obo:CL_0000818, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001318 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001338 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001880 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000958 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000818 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001880 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] ) ] . obo:CL_0000960 obo:IAO_0000115 "A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM)." ; oboInOwl:hasExactSynonym "An1 B cell", "T3 B lymphocyte", "T3 B-cell", "T3 B-lymphocyte", "transitional stage 3 B cell" ; a owl:Class ; rdfs:label "T3 B cell" ; rdfs:subClassOf obo:CL_0000818, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0002515 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001318 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001338 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001880 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000959 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000818 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0002515 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001880 ] ) ] . obo:CL_0000961 obo:IAO_0000115 "A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells." ; oboInOwl:hasExactSynonym "Bm1 B lymphocyte", "Bm1 B-cell", "Bm1 B-lymphocyte" ; a owl:Class ; rdfs:comment "These cells are also reportedly CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative." ; rdfs:label "Bm1 B cell" ; rdfs:subClassOf obo:CL_0000843, obo:CL_0002056, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000843 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001880 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] ) ] . obo:CL_0000962 obo:IAO_0000115 "A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells." ; oboInOwl:hasExactSynonym "Bm2 B lymphocyte", "Bm2 B-cell", "Bm2 B-lymphocyte" ; a owl:Class ; rdfs:comment "These cells are also CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative." ; rdfs:label "Bm2 B cell" ; rdfs:subClassOf obo:CL_0000843, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001880 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000961 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000843 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001880 ] ) ] . obo:CL_0000963 obo:IAO_0000115 "A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive." ; oboInOwl:hasExactSynonym "Bm3-delta B lymphocyte", "Bm3-delta B-cell", "Bm3-delta B-lymphocyte" ; a owl:Class ; rdfs:label "Bm3-delta B cell" ; rdfs:subClassOf obo:CL_0000844, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071753 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000965 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000844 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0000964 obo:IAO_0000115 "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative." ; oboInOwl:hasExactSynonym "Bm2' B lymphocyte", "Bm2' B-cell", "Bm2-prime B cell", "Bm2-prime B-lymphocyte" ; oboInOwl:hasRelatedSynonym "germinal center founder cell" ; a owl:Class ; rdfs:comment "Bm2' B cells are also reportedly CD10-positive, CD39-negative, CD44-negative, CD71-positive, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative." ; rdfs:label "Bm2' B cell" ; rdfs:subClassOf obo:CL_0000844, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001880 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000962 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002634 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000844 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001880 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002634 ] ) ] . obo:CL_0000965 obo:IAO_0000115 "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." ; oboInOwl:hasExactSynonym "Bm3 B lymphocyte", "Bm3 B-cell", "Bm3 B-lymphocyte" ; oboInOwl:hasRelatedSynonym "centroblast" ; a owl:Class ; rdfs:comment "Bm3 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-negative, CD71-positive, and CD77-positive." ; rdfs:label "Bm3 B cell" ; rdfs:subClassOf obo:CL_0000844, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000003516 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000964 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0016446 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000844 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000003516 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0016446 ] ) ] . obo:CL_0000966 obo:IAO_0000115 "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor." ; oboInOwl:hasExactSynonym "Bm4 B lymphocyte", "Bm4 B-cell", "Bm4 B-lymphocyte" ; oboInOwl:hasRelatedSynonym "centrocyte" ; a owl:Class ; rdfs:comment "Bm4 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-positive, and CD71-positive." ; rdfs:label "Bm4 B cell" ; rdfs:subClassOf obo:CL_0000844, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000003516 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000963 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016446 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000844 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000003516 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016446 ] ) ] . obo:CL_0000967 obo:IAO_0000115 "A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes." ; oboInOwl:hasExactSynonym "Bm5 B lymphocyte", "Bm5 B-cell", "Bm5 B-lymphocyte" ; a owl:Class ; rdfs:comment "Bm5 B cells are also reportedly CD10-positive, CD23-negative, CD38-negative, CD39-positive, CD44-positive, CD71-positive, and CD77-negative." ; rdfs:label "Bm5 B cell" ; rdfs:subClassOf obo:CL_0001053, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000966 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0002314 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016446 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000787 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0002314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016446 ] ) ] . obo:CL_0000968 obo:IAO_0000115 "A mature B cell that produces cytokines that can influence CD4 T cell differentiation." ; oboInOwl:hasExactSynonym "B effector cell", "effector B cell", "effector B lymphocyte", "effector B-cell", "effector B-lymphocyte" ; a owl:Class ; rdfs:label "Be cell" ; rdfs:subClassOf obo:CL_0000785, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043370 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043370 ] ) ] . obo:CL_0000969 obo:IAO_0000115 "A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses." ; oboInOwl:hasExactSynonym "B(reg)", "B10 cell", "Breg", "regulatory B lymphocyte", "regulatory B-cell", "regulatory B-lymphocyte" ; a owl:Class ; rdfs:comment "Regulatory B cells reportedly represent 1-2% of the spleen and 7-8% of the peritoneal B220-positive cells in mice. They are also found in the bone marrow, lymph node, and blood of mice. These cells are also reportedly capable of secreting IL-10 and are reportedly CD5-positive, CD21-positive, CD24-positive, CD93-negative, B220-positive, IgM-positive, and IgD-positive." ; rdfs:label "regulatory B cell" ; rdfs:subClassOf obo:CL_0000785, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002028 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002028 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] ) ] . obo:CL_0000970 obo:IAO_0000115 "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "IgD+ memory B cell" ; oboInOwl:hasExactSynonym "non-class-switched memory B cell", "unswitched memory B lymphocyte", "unswitched memory B-cell", "unswitched memory B-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'IgD+ memory B cell'. Per DSD: Unswitched memory B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive." ; rdfs:label "unswitched memory B cell" ; rdfs:subClassOf obo:CL_0000787, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071735 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071742 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071745 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001963 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000980 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000787 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071735 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071742 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071745 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001935 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001963 ] ) ] . obo:CL_0000971 obo:IAO_0000115 "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." ; oboInOwl:hasExactSynonym "IgM memory B lymphocyte", "IgM memory B-cell", "IgM memory B-lymphocyte", "memory IgM B cell", "memory IgM B lymphocyte", "memory IgM B-cell", "memory IgM B-lymphocyte" ; a owl:Class ; rdfs:comment "IgM memory B cells are also reportedly CD1c-positive, CD95-positive, CD80-positive, CD84-positive, CD86-positive, CD150-negative, CD229-positive, CD289-positive, and CD290-positive. Transcription factors: Notch2-positive, PAX5-positive, SpiB-positive, Ets1-positive, and OBF1-positive." ; rdfs:label "IgM memory B cell" ; rdfs:subClassOf obo:CL_0001053, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000787 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] ) ] . obo:CL_0000972 obo:IAO_0000115 "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "class switched memory B lymphocyte", "class switched memory B-cell", "class switched memory B-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Per DSD: Class switched memory B cells are also reportedly CD48-positive, CD229-positive, and CD352-positive." ; rdfs:label "class switched memory B cell" ; rdfs:subClassOf obo:CL_0000787, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071753 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001963 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000970 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0045190 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000787 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001963 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0045190 ] ) ] . obo:CL_0000973 obo:IAO_0000115 "A class switched memory B cell that expresses IgA." ; oboInOwl:hasExactSynonym "IgA memory B lymphocyte", "IgA memory B-cell", "IgA memory B-lymphocyte", "memory IgA B cell", "memory IgA B lymphocyte", "memory IgA B-cell", "memory IgA B-lymphocyte" ; a owl:Class ; rdfs:comment "IgA memory B cell are also reportedly RORalpha-positive." ; rdfs:label "IgA memory B cell" ; rdfs:subClassOf obo:CL_0000972, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071745 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000972 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071745 ] ) ] . obo:CL_0000974 obo:IAO_0000115 "A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow." ; a owl:Class ; rdfs:label "long lived plasma cell" ; rdfs:subClassOf obo:CL_0000786, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000975 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001208 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001935 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001002 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000786 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0019814 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001208 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001935 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001002 ] ) ] . obo:CL_0000975 obo:IAO_0000115 "A fully differentiated plasma cell that lives for months." ; a owl:Class ; rdfs:label "short lived plasma cell" ; rdfs:subClassOf obo:CL_0000786, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001604 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000786 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001604 ] ) ] . obo:CL_0000976 obo:IAO_0000115 "A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system." ; a owl:Class ; rdfs:label "IgA short lived plasma cell" ; rdfs:subClassOf obo:CL_0000975, [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071746 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000975 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071746 ] ) ] . obo:CL_0000977 obo:IAO_0000115 "A short lived plasma cell that secretes IgG." ; a owl:Class ; rdfs:label "IgG short lived plasma cell" ; rdfs:subClassOf obo:CL_0000975, [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071736 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000975 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071736 ] ) ] . obo:CL_0000978 obo:IAO_0000115 "A short lived plasma cell that secretes IgM." ; a owl:Class ; rdfs:label "IgM short lived plasma cell" ; rdfs:subClassOf obo:CL_0000975, [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071754 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000975 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071754 ] ) ] . obo:CL_0000979 obo:IAO_0000115 "An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface." ; oboInOwl:hasExactSynonym "IgG memory B lymphocyte", "IgG memory B-cell", "IgG memory B-lymphocyte", "memory IgG B cell", "memory IgG B lymphocyte", "memory IgG B-cell", "memory IgG B-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "IgG memory B cell" ; rdfs:subClassOf obo:CL_0000972, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071735 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000972 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071735 ] ) ] . obo:CL_0000980 obo:IAO_0000115 "An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "CD20-negative B cell" ; oboInOwl:hasDbXref "FMA:84371" ; oboInOwl:hasExactSynonym "CD27-positive, CD38-positive, CD20-negative B cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'plasmablast'. Plasmablasts are also reportedly CD48-positive, CD63-positive, CD229-positive, CD270-positive, CD319-positive, CD352-positive, CD361-positive, and IgD-negative." ; rdfs:label "plasmablast" ; rdfs:subClassOf obo:CL_0000785, obo:CL_0000946, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001935 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000785 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001963 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001935 ] [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0042571 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001963 ] ) ] . obo:CL_0000981 obo:IAO_0000115 "A memory B cell with the phenotype IgD-negative and CD27-negative." ; oboInOwl:hasExactSynonym "dn memory B cell", "dn memory B lymphocyte", "dn memory B-cell", "dn memory B-lymphocyte", "double negative memory B lymphocyte", "double negative memory B-cell", "double negative memory B-lymphocyte" ; a owl:Class ; rdfs:label "double negative memory B cell" ; rdfs:subClassOf obo:CL_0001053, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001963 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000787 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001963 ] ) ] . obo:CL_0000982 obo:IAO_0000115 "A plasmablast that secretes IgG." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "IgG plasmablast" ; rdfs:subClassOf obo:CL_0000980, [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071736 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000980 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071736 ] ) ] . obo:CL_0000983 obo:IAO_0000115 "A plasmablast that secretes IgM." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "IgM plasmablast" ; rdfs:subClassOf obo:CL_0000980, [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071754 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000980 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071754 ] ) ] . obo:CL_0000984 obo:IAO_0000115 "A plasmablast that secretes IgA." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "IgA plasmablast" ; rdfs:subClassOf obo:CL_0000980, [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071746 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000980 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071746 ] ) ] . obo:CL_0000985 obo:IAO_0000115 "A fully differentiated plasma cell that secretes IgG." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "IgG plasma cell" ; rdfs:subClassOf obo:CL_0000974, [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071736 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000974 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071736 ] ) ] . obo:CL_0000986 obo:IAO_0000115 "A fully differentiated plasma cell that secretes IgM." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "IgM plasma cell" ; rdfs:subClassOf obo:CL_0000974, [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071754 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000974 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071754 ] ) ] . obo:CL_0000987 obo:IAO_0000115 "A fully differentiated plasma cell that secretes IgA." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "IgA plasma cell" ; rdfs:subClassOf obo:CL_0000974, [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071746 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000974 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071746 ] ) ] . obo:CL_0000988 obo:IAO_0000115 "A cell of a hematopoietic lineage." ; oboInOwl:hasDbXref "BTO:0000574", "CALOHA:TS-2017", "FMA:70366", "FMA:83598", "ZFA:0005830" ; oboInOwl:hasExactSynonym "haematopoietic cell", "haemopoietic cell", "hemopoietic cell" ; oboInOwl:inSubset cl:cellxgene_subset, cl:general_cell_types_upper_slim ; a owl:Class ; rdfs:label "hematopoietic cell" ; rdfs:subClassOf obo:CL_0000000 ; skos:prefLabel "hematopoietic cell" . obo:CL_0000989 obo:IAO_0000115 "CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative." ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000001)(PMID:19243617). These cells are CD281-positive (TLR1), CD282-positive (TLR2), CD285-positive (TLR5), CD286-positive (TLR6), and CD288-positive (TLR8)." ; rdfs:label "CD11c-low plasmacytoid dendritic cell" ; rdfs:subClassOf obo:CL_0000784, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002978 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001013 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000784 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001013 ] ) ] . obo:CL_0000990 obo:IAO_0000115 "Conventional dendritic cell is a dendritic cell that is CD11c-high." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "interdigitating cell", "veiled cell" ; oboInOwl:hasDbXref "FMA:84191" ; oboInOwl:hasExactSynonym "DC1", "cDC", "dendritic reticular cell", "type 1 DC" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive." ; rdfs:label "conventional dendritic cell" ; rdfs:subClassOf obo:CL_0000451, [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001013 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000451 [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001013 ] ) ] . obo:CL_0000991 obo:IAO_0000115 "CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD45RA-positive, CD85g-positive(ILT7), CD123-positive, CD303-positive." ; oboInOwl:hasExactSynonym "CD303-positive dendritic cell" ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000004)(PMID:19243617). These cells are CD281-positive (TLR1), CD286-positive (TLR6), and CD290-positive (TLR10)." ; rdfs:label "CD11c-negative plasmacytoid dendritic cell" ; rdfs:subClassOf obo:CL_0000784, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001292 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001398 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001865 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000784 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001292 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001398 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032606 ] ) ] . obo:CL_0000992 obo:IAO_0000115 "Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD80-low and CD86-low." ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000006)(PMID:19243617)." ; rdfs:label "immature CD11c-low plasmacytoid dendritic cell" ; rdfs:subClassOf obo:CL_0000766, obo:CL_0000989, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001029 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001412 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001438 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000989 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0000993 obo:IAO_0000115 "Mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD83-high and is CD80-positive, CD86-positive, and MHCII-positive." ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000007)(PMID:19243617)." ; rdfs:label "mature CD11c-low plasmacytoid dendritic cell" ; rdfs:subClassOf obo:CL_0000766, obo:CL_0000989, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001310 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000992 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001412 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001438 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000989 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0000994 obo:IAO_0000115 "Immature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-negative, CD86-low and MHCII-low." ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000008)(PMID:19243617)." ; rdfs:label "immature CD11c-negative plasmacytoid dendritic cell" ; rdfs:subClassOf obo:CL_0000991, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001438 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000995 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001412 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000991 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001438 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0019882 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001412 ] ) ] . obo:CL_0000995 oboInOwl:hasBroadSynonym "CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid" ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617)." ; rdfs:label "CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor" ; rdfs:subClassOf obo:CL_0001060, obo:CL_0011026 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:CL_0001021 obo:CL_0001026 ) ] . obo:CL_0000996 obo:IAO_0000115 "Mature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000009)(PMID:19243617)." ; rdfs:label "mature CD11c-negative plasmacytoid dendritic cell" ; rdfs:subClassOf obo:CL_0000991, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001310 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000994 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001412 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001438 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000991 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0000997 obo:IAO_0000115 "Immature CD8-alpha-negative CD11b-positive dendritic cell is a CD8-alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low." ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000010)(PMID:19243617)." ; rdfs:label "immature CD8-alpha-negative CD11b-positive dendritic cell" ; rdfs:subClassOf obo:CL_0000840, obo:CL_0000999 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000999 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0000998 obo:IAO_0000115 "CD8-alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8-alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells." ; oboInOwl:hasExactSynonym "DC.8-4-11b-", "triple negative dendritic cell" ; a owl:Class ; rdfs:comment "These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000011)(PMID:19243617)." ; rdfs:label "CD8-alpha-negative CD11b-negative dendritic cell" ; rdfs:subClassOf obo:CL_0000766, obo:CL_0000990, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001026 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002010 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002474 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001026 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002474 ] ) ] . obo:CL_0000999 obo:IAO_0000115 "CD8-alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8-alpha-negative." ; oboInOwl:hasExactSynonym "DC.4+" ; a owl:Class ; rdfs:comment "Defined as having a disposition to secreting anti-inflammatory cytokines. These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000012)(PMID:19243617)." ; rdfs:label "CD4-positive CD11b-positive dendritic cell" ; rdfs:subClassOf obo:CL_0000766, obo:CL_0002465, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001026 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002010 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050728 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001026 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050728 ] ) ] . obo:CL_0001000 obo:IAO_0000115 "CD8-alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8-alpha-positive." ; oboInOwl:hasExactSynonym "DC.8+" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Cells are defined as having a disposition to secreting inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000013)(PMID:19243617)." ; rdfs:label "CD8-alpha-positive CD11b-negative dendritic cell" ; rdfs:subClassOf obo:CL_0000766, obo:CL_0000990, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001026 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002010 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042590 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050729 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001026 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042590 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050729 ] ) ] . obo:CL_0001001 obo:IAO_0000115 "Immature CD8-alpha-negative CD11b-negative dendritic cell is a CD8-alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." ; a owl:Class ; rdfs:comment "These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000014)(PMID:19243617)." ; rdfs:label "immature CD8-alpha-negative CD11b-negative dendritic cell" ; rdfs:subClassOf obo:CL_0000840, obo:CL_0000998 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000998 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0001002 obo:IAO_0000115 "Mature CD8-alpha-negative CD11b-negative dendritic cell is a CD8-alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." ; a owl:Class ; rdfs:comment "These markers are associated with mouse cells. Defined as having a disposition to secretion of anti-inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000015)(PMID:19243617)." ; rdfs:label "mature CD8-alpha-negative CD11b-negative dendritic cell" ; rdfs:subClassOf obo:CL_0000841, obo:CL_0000998, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000998 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0001003 obo:IAO_0000115 "Mature CD8-alpha-negative CD11b-positive dendritic cell is a CD8-alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000016)(PMID:19243617)." ; rdfs:label "mature CD8-alpha-negative CD11b-positive dendritic cell" ; rdfs:subClassOf obo:CL_0000841, obo:CL_0000999, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000997 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000999 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0001004 obo:IAO_0000115 "Immature CD8-alpha-positive CD11b-negative dendritic cell is a CD8-alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000017)(PMID:19243617)." ; rdfs:label "immature CD8-alpha-positive CD11b-negative dendritic cell" ; rdfs:subClassOf obo:CL_0000840, obo:CL_0001000 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001000 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0001005 obo:IAO_0000115 "Mature CD8-alpha-positive CD11b-negative dendritic cell is a CD8-alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000018)(PMID:19243617)." ; rdfs:label "mature CD8-alpha-positive CD11b-negative dendritic cell" ; rdfs:subClassOf obo:CL_0000841, obo:CL_0001000, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001004 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001000 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0001006 obo:IAO_0000115 "Dermal dendritic cell is a conventional dendritic cell that is CD11b-positive, CD205-positive and CD8 alpha-negative." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0004812" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000019)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD288-positive (TLR8), and CD289-positive (TLR9)." ; rdfs:label "dermal dendritic cell" ; rdfs:subClassOf obo:CL_0002465, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001026 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001084 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001026 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001084 ] ) ] . obo:CL_0001007 obo:IAO_0000115 "Interstitial dendritic cell is a conventional dendritic cell that is CD11b-positive, CD1a-positive, CD206-positive, CD209-positive, and CD36-positive." ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000020)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10)." ; rdfs:label "interstitial dendritic cell" ; rdfs:subClassOf obo:CL_0002465, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001300 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001905 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002025 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002972 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001300 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001905 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002025 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002972 ] ) ] . obo:CL_0001008 obo:IAO_0000115 "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." ; oboInOwl:hasExactSynonym "LSK stem cell", "Sca1-positive hematopoietic stem cell" ; a owl:Class ; rdfs:comment "Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617)." ; rdfs:label "Kit and Sca1-positive hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0000037, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001014 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001308 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001896 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002977 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001833 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ] ; owl:disjointWith obo:CL_0001024 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000037 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001308 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001896 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002977 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001833 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ] ) ] . obo:CL_0001009 obo:IAO_0000115 "Immature dermal dendritic cell is a dermal dendritic cell that is CD80-low, CD86-low, and MHCII-low." ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000022)(PMID:19243617)." ; rdfs:label "immature dermal dendritic cell" ; rdfs:subClassOf obo:CL_0000840, obo:CL_0001006 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001006 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0001010 obo:IAO_0000115 "Mature dermal dendritic cell is a dermal dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000023)(PMID:19243617)." ; rdfs:label "mature dermal dendritic cell" ; rdfs:subClassOf obo:CL_0000841, obo:CL_0001006, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001009 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001006 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0001011 obo:IAO_0000115 "Immature interstitial dendritic cell is a interstitial dendritic cell that is CD80-low, CD86-low, and MHCII-low." ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000024)(PMID:19243617)." ; rdfs:label "immature interstitial dendritic cell" ; rdfs:subClassOf obo:CL_0000840, obo:CL_0001007 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001007 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0001012 a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617)." ; rdfs:label "CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor" ; rdfs:subClassOf obo:CL_0001060, obo:CL_0011026 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:CL_0000557 obo:CL_0001027 ) ] . obo:CL_0001013 obo:IAO_0000115 "Mature interstitial dendritic cell is a interstitial dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000025)(PMID:19243617)." ; rdfs:label "mature interstitial dendritic cell" ; rdfs:subClassOf obo:CL_0000841, obo:CL_0001007, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001011 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001007 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0001014 obo:IAO_0000115 "CD1a-positive Langerhans cell is a Langerhans_cell that is CD1a-positive and CD324-positive." ; oboInOwl:hasExactSynonym "CD1a-LC" ; a owl:Class ; rdfs:comment "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000026)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD286-positive (TLR6), CD287-positive (TLR7), and CD290-positive (TLR10). When activated, these cells are capable of producing IL-6, IL-8, and IL-15." ; rdfs:label "CD1a-positive Langerhans cell" ; rdfs:subClassOf obo:CL_0000453, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001447 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002025 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000453 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001447 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002025 ] ) ] . obo:CL_0001015 obo:IAO_0000115 "CD8-alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8-alpha-low." ; a owl:Class ; rdfs:comment "These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000027)(PMID:19243617). They are also CD205-high, CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD285-positive (TLR5), CD286-positive (TLR6), and CD289-positive (TLR9)." ; rdfs:label "CD8-alpha-low Langerhans cell" ; rdfs:subClassOf obo:CL_0000453, [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001026 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001084 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000453 [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001026 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001084 ] ) ] . obo:CL_0001016 obo:IAO_0000115 "Immature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-low, CD86-low, and MHCII-low." ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000028)(PMID:19243617)." ; rdfs:label "immature CD1a-positive Langerhans cell" ; rdfs:subClassOf obo:CL_0000840, obo:CL_0001014 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001014 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0001017 obo:IAO_0000115 "Mature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000029)(PMID:19243617). When activated, these cells produce IL-6, IL-8, and IL-15." ; rdfs:label "mature CD1a-positive Langerhans cell" ; rdfs:subClassOf obo:CL_0000841, obo:CL_0001014, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001016 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001014 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0001018 obo:IAO_0000115 "Immature CD8-alpha-low Langerhans cell is a CD8-alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low." ; a owl:Class ; rdfs:comment "These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000030)(PMID:19243617)." ; rdfs:label "immature CD8-alpha-low Langerhans cell" ; rdfs:subClassOf obo:CL_0000840, obo:CL_0001015 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001015 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0001019 a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617)." ; rdfs:label "CD115-positive monocyte OR common dendritic progenitor" ; rdfs:subClassOf obo:CL_0000763, obo:CL_0002031 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:CL_0001022 obo:CL_0001029 ) ] . obo:CL_0001020 obo:IAO_0000115 "Mature CD8-alpha-low Langerhans cell is a CD8-alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive." ; a owl:Class ; rdfs:comment "These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000031)(PMID:19243617)." ; rdfs:label "mature CD8-alpha-low Langerhans cell" ; rdfs:subClassOf obo:CL_0000841, obo:CL_0001015, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001018 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001015 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0001021 obo:IAO_0000115 "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." ; oboInOwl:hasExactSynonym "CD10-positive common lymphocyte precursor", "CD10-positive common lymphocyte progenitor", "CD10-positive common lymphoid precursor" ; a owl:Class ; rdfs:comment "These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617)." ; rdfs:label "CD34-positive, CD38-positive common lymphoid progenitor" ; rdfs:subClassOf obo:CL_0000051, obo:CL_0000995, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001898 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002043 ] ; owl:disjointWith obo:CL_0001025 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001898 ] ) ] . obo:CL_0001022 obo:IAO_0000115 "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." ; a owl:Class ; rdfs:comment "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617)." ; rdfs:label "CD115-positive monocyte" ; rdfs:subClassOf obo:CL_0000576, obo:CL_0000839, obo:CL_0001019, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000576 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ] ) ] . obo:CL_0001023 obo:IAO_0000115 "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low." ; oboInOwl:hasBroadSynonym "CD117-positive common myeloid precursor" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617)." ; rdfs:label "Kit-positive, CD34-positive common myeloid progenitor" ; rdfs:subClassOf obo:CL_0001030, obo:CL_0001059, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002035 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0033001 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001481 ] ; owl:disjointWith obo:CL_0001026 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001059 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0033001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001481 ] ) ] . obo:CL_0001024 obo:IAO_0000115 "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." ; oboInOwl:hasDbXref "CALOHA:TS-0448" ; oboInOwl:hasExactSynonym "CD133-positive hematopoietic stem cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617)." ; rdfs:label "CD34-positive, CD38-negative hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0000037, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001483 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001892 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001945 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001786 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001809 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001843 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000037 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001892 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001945 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001786 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001809 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001843 ] ) ] . obo:CL_0001025 obo:IAO_0000115 "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low." ; oboInOwl:hasExactSynonym "CD217-positive common lymphocyte precursor", "CD217-positive common lymphocyte progenitor", "CD217-positive common lymphoid precursor" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Kit-positive, Sca1-positive common lymphoid progenitor" ; rdfs:subClassOf obo:CL_0000051, obo:CL_0001030, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001014 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001963 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002001 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000936 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002979 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000051 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001963 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002979 ] ) ] . obo:CL_0001026 obo:IAO_0000115 "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." ; oboInOwl:hasNarrowSynonym "CD71-positive common myeloid precursor" ; a owl:Class ; rdfs:comment "Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617)." ; rdfs:label "CD34-positive, CD38-positive common myeloid progenitor" ; rdfs:subClassOf obo:CL_0000995, obo:CL_0001059, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001836 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001867 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001898 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002043 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001865 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001059 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001836 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001867 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001898 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001865 ] ) ] . obo:CL_0001027 obo:IAO_0000115 "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." ; oboInOwl:hasExactSynonym "CD7-negative lymphoid precursor" ; a owl:Class ; rdfs:comment "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617)." ; rdfs:label "CD7-negative lymphoid progenitor cell" ; rdfs:subClassOf obo:CL_0000051, obo:CL_0001012, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001836 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001021 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000051 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001836 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] ) ] . obo:CL_0001028 obo:IAO_0000115 "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." ; oboInOwl:hasExactSynonym "CD7-positive lymphoid precursor" ; a owl:Class ; rdfs:comment "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617)." ; rdfs:label "CD7-positive lymphoid progenitor cell" ; rdfs:subClassOf obo:CL_0000051, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001836 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001027 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000051 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001836 ] ) ] . obo:CL_0001029 obo:IAO_0000115 "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." ; oboInOwl:hasExactSynonym "CDP", "common dendritic precursor", "pro-DCs" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617)." ; rdfs:label "common dendritic progenitor" ; rdfs:subClassOf obo:CL_0001019, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002001 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002009 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002065 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002031 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002065 ] ) ] . obo:CL_0001030 a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617)." ; rdfs:label "CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor" ; rdfs:subClassOf obo:CL_0001060, obo:CL_0011026 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:CL_0001023 obo:CL_0001025 ) ] . obo:CL_0001031 obo:IAO_0000115 "An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. A mature cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers." ; oboInOwl:hasDbXref "BTO:0004278", "ZFA:0001691" ; oboInOwl:hasExactSynonym "granule cell of the cerebellum" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "It has been noted in at least some mammalian species that granule cells are the most numerous cell type in the cerebellum and in the brain, with at least 99% of all cerebellar neurons being granule cells." ; rdfs:label "cerebellar granule cell" ; rdfs:subClassOf obo:CL_0000120, obo:CL_2000028, obo:UBERON_0004121, [ a owl:Restriction ; owl:onProperty obo:RO_0002207 ; owl:someValuesFrom obo:CL_0002362 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000120 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] ; skos:prefLabel "cerebellar granule cell" ; foaf:depiction , . obo:CL_0001032 obo:IAO_0000115 "Granule cell that is part of the cerebral cortex." ; a owl:Class ; rdfs:label "cortical granule cell" ; rdfs:subClassOf obo:CL_0000120, obo:CL_0010012 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000120 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] ; skos:prefLabel "cortical granule cell" . obo:CL_0001033 obo:IAO_0000115 "Granule cell with a soma found in the hippocampus." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "hippocampal granule cell" ; rdfs:subClassOf obo:CL_0001032, obo:CL_0002608 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000120 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002421 ] ) ] ; skos:prefLabel "hippocampal granule cell" . obo:CL_0001034 obo:IAO_0000115 "A cell that is maintained or propagated in a controlled artificial environment for use in an investigation." ; terms:contributor ; oboInOwl:creation_date "2012-01-12T09:58:38Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "'In vitro', translating literally to 'in glass', typically refers to a controlled, often sterile, laboratory setting where cells or other specimens are placed by some agent for the purpose of studying or manipulating them as part of some research investigation. 'In vitro' is intended to contrast with 'native',which refers to cells or other biological entities that are found in a natural setting. It describes unicellular organisms removed from a natural environement and multicellular organism cells removed from an organism, or cells derived in culture from such displaced cells." ; rdfs:label "cell in vitro" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0001035 obo:IAO_0000115 "A connective tissue cell found in bone." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Bone cells, also known as osteocytes, form the building blocks of the skeletal system. They represent the most common type of bone cell, making up approximately 95% of the total bone cell population in mature adult bone tissue. Osteocytes are a stellate shape with numerous long, slender dendritic processes. The formation of bone is a complex process involving the action of osteoclasts - cells that break down and reabsorb old bone, followed by osteoblasts that rebuild the bone. Osteocytes serve as coordinators for these two types of bone cells to ensure a balance in the bone remodeling process, contributing to maintaining both bone strength and mineral homeostasis. The primary functions of osteocytes involve the creation, maintenance, and repair of bone tissue. They ensure that bone remodeling is performed by forming a network within the bone and communicating with other cells to help them respond to mechanical strain and damage. A remarkable aspect of osteocytes is their ability to perceive mechanical forces, translating them into biochemical signals that regulate bone remodeling and adaptation. Defects in osteocyte function, aside from other bone cells, have been associated with several bone disorders such as osteoporosis, renal osteodystrophy, and skeletal manifestations of diabetes. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2011-11-16T04:28:16Z"^^xsd:dateTime ; oboInOwl:inSubset cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "bone cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0001035" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001474 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001474 ] ) ] . obo:CL_0001039 obo:IAO_0000115 "Osteoblast that is terminally differentiated, located adjacent to acellular or cellular bone tissue within periosteum, and is capable of mineralizing the matrix." ; oboInOwl:hasDbXref "VSAO:0000116" ; a owl:Class ; rdfs:label "terminally differentiated osteoblast" ; rdfs:subClassOf obo:CL_0000062 . obo:CL_0001040 obo:IAO_0000115 "Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone." ; oboInOwl:hasDbXref "VSAO:0000117" ; a owl:Class ; rdfs:comment "VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118" ; rdfs:label "non-terminally differentiated osteoblast" ; rdfs:subClassOf obo:CL_0000062, obo:CL_0001035, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002481 ] . obo:CL_0001041 obo:IAO_0000115 "A CD8-positive alpha-beta-positive T cell with the phenotype CXCR3-positive and having suppressor function. They are capable of producing IL-10, suppressing proliferation, and suppressing IFN-gamma production." ; oboInOwl:hasExactSynonym "CD8+CXCR3+ T cell", "CD8+CXCR3+ T lymphocyte", "CD8+CXCR3+ T(reg)", "CD8+CXCR3+ T-cell", "CD8+CXCR3+ Treg", "CD8-positive, CXCR3-positive, T(reg)", "CD8-positive, CXCR3-positive, Treg", "CD8-positive, CXCR3-positive, alpha-beta regulatory T lymphocyte", "CD8-positive, CXCR3-positive, alpha-beta regulatory T-cell", "CD8-positive, CXCR3-positive, alpha-beta regulatory T-lymphocyte" ; a owl:Class ; rdfs:comment "These cells may be the human equivalent of murine CD8-positive, CD122-positive alpha-beta regulatory T cell. They are also found in the CD45RA-negative and CD62L-positive fraction." ; rdfs:label "CD8-positive, CXCR3-positive, alpha-beta regulatory T cell" ; rdfs:subClassOf obo:CL_0000795, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001207 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032689 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042130 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000795 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001207 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032689 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042130 ] ) ] . obo:CL_0001042 obo:IAO_0000115 "CD4-positive, alpha-beta T cell that produces IL-22." ; oboInOwl:hasExactSynonym "T(H)-22 cell", "Th22 T cell", "Th22 T lymphocyte", "Th22 T-cell", "Th22 T-lymphocyte", "Th22 cell", "helper T cell type 22" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "TH22 cells are also reportedly CCR4-positive, CCR6-positive, CCR10-positive, CXCR3-negative. TH22 cells are reportedly capable of secreting IL-13." ; rdfs:label "T-helper 22 cell" ; rdfs:subClassOf obo:CL_0000492, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032626 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000492 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032626 ] ) ] . obo:CL_0001043 obo:IAO_0000115 "A recently activated CD4-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." ; oboInOwl:hasBroadSynonym "activated CD4+ T cell" ; oboInOwl:hasExactSynonym "activated CD4-positive, alpha-beta T lymphocyte, human", "activated CD4-positive, alpha-beta T-cell, human", "activated CD4-positive, alpha-beta T-lymphocyte, human" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'activated CD4+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD4+ T cells. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II." ; rdfs:label "activated CD4-positive, alpha-beta T cell, human" ; rdfs:subClassOf obo:CL_0000896, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000896 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0001044 obo:IAO_0000115 "A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." ; oboInOwl:hasBroadSynonym "effector CD4+ T cell" ; oboInOwl:hasExactSynonym "effector CD4-positive, alpha-beta T lymphocyte", "effector CD4-positive, alpha-beta T-cell", "effector CD4-positive, alpha-beta T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'effector CD4+ T cell'. The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy." ; rdfs:label "effector CD4-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000624, obo:CL_0000911, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000911 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] ) ] . obo:CL_0001045 obo:IAO_0000115 "A naive regulatory T cell with the phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-negative." ; oboInOwl:hasExactSynonym "naive CCR4+ Treg", "naive CCR4-positive regulatory T lymphocyte", "naive CCR4-positive regulatory T-cell", "naive CCR4-positive regulatory T-lymphocyte" ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'naive CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown." ; rdfs:label "naive CCR4-positive regulatory T cell" ; rdfs:subClassOf obo:CL_0001047, obo:CL_0002677, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001017 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002677 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001200 ] ) ] . obo:CL_0001046 obo:IAO_0000115 "A memory regulatory T cell with phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-positive." ; oboInOwl:hasExactSynonym "memory CCR4+ Treg", "memory CCR4-positive regulatory T lymphocyte", "memory CCR4-positive regulatory T-cell", "memory CCR4-positive regulatory T-lymphocyte" ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'memory CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown." ; rdfs:label "memory CCR4-positive regulatory T cell" ; rdfs:subClassOf obo:CL_0001047, obo:CL_0002678, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002678 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001200 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0001047 obo:IAO_0000115 "A CD4-positive, CD25-positive, alpha-beta regulatory T cell with the additional phenotype CCR4-positive." ; oboInOwl:hasExactSynonym "CCR+ Treg", "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte", "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell", "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte" ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown." ; rdfs:label "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell" ; rdfs:subClassOf obo:CL_0000792, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001200 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000792 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001200 ] ) ] . obo:CL_0001048 obo:IAO_0000115 "A CD4-positive, CD25-positive, CCR4-positive, alpha-beta T regulatory cell with the phenotype HLA-DRA-positive, indicating recent activation." ; oboInOwl:hasExactSynonym "activated CCR4+ Treg", "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte", "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell", "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte" ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'activated CCR4+ Treg'. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II." ; rdfs:label "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell, human" ; rdfs:subClassOf obo:CL_0001047, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001047 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0001049 obo:IAO_0000115 "A recently activated CD8-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, CCR7-negative, and CD25-positive." ; oboInOwl:hasBroadSynonym "activated CD8+ T cell" ; oboInOwl:hasExactSynonym "activated CD8-positive, alpha-beta T lymphocyte, human", "activated CD8-positive, alpha-beta T-cell, human", "activated CD8-positive, alpha-beta T-lymphocyte, human" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'activated CD8+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD8+ T cells. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD8+ T cells, as activated mouse T cells do not express MHC class II." ; rdfs:label "activated CD8-positive, alpha-beta T cell, human" ; rdfs:subClassOf obo:CL_0000906, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000906 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0001050 obo:IAO_0000115 "A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "effector CD8+ T cell" ; oboInOwl:hasExactSynonym "effector CD8-positive, alpha-beta T lymphocyte", "effector CD8-positive, alpha-beta T-cell", "effector CD8-positive, alpha-beta T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'effector CD8+ T cell'. The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy." ; rdfs:label "effector CD8-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000625, obo:CL_0000911, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000911 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000025402 ] ) ] . obo:CL_0001051 obo:IAO_0000115 "A CD4-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." ; oboInOwl:hasBroadSynonym "non-Th1/Th17 CD4+ T cell" ; oboInOwl:hasExactSynonym "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte", "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell", "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell'. Cells of this phenotype may include T-helper 2 T cells and some naive CD4+ T cells." ; rdfs:label "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000624, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001202 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001207 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001202 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001207 ] ) ] . obo:CL_0001052 obo:IAO_0000115 "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." ; oboInOwl:hasBroadSynonym "non-Tc1/Tc17 CD8+ T cell" ; oboInOwl:hasExactSynonym "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte", "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell", "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell'. Cells of this phenotype may include Tc2 T cells and some naive CD8+ T cells." ; rdfs:label "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000625, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001202 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001207 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000625 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001202 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001207 ] ) ] . obo:CL_0001053 obo:IAO_0000115 "A memory B cell that lacks expression of surface IgD." ; oboInOwl:hasExactSynonym "IgD- memory B cell" ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'IgD- memory B cell'. The majority of these cells are class-switched, though some are IgM-positive." ; rdfs:label "IgD-negative memory B cell" ; rdfs:subClassOf obo:CL_0000787, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000787 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] ) ] . obo:CL_0001054 obo:IAO_0000115 "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasNarrowSynonym "monocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes." ; rdfs:label "CD14-positive monocyte" ; rdfs:subClassOf obo:CL_0000576, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001889 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000576 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001889 ] ) ] . obo:CL_0001055 obo:IAO_0000115 "An intermediate monocyte that is CD14-positive and with low amounts of CD16." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "intermediate monocyte, human" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Definition is valid for human intermediate monocytes." ; rdfs:label "CD14-positive, CD16-low monocyte" ; rdfs:subClassOf obo:CL_0002393, obo:CL_0002397, [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001483 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002393 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001483 ] ) ] . obo:CL_0001056 obo:IAO_0000115 "A dendritic cell with the phenotype HLA-DRA-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "dendritic cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human dendritic cells." ; rdfs:label "dendritic cell, human" ; rdfs:subClassOf obo:CL_0000451, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000451 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0001057 obo:IAO_0000115 "A myeloid dendritic cell with the phenotype HLA-DRA-positive." ; oboInOwl:hasBroadSynonym "myeloid dendritic cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'myeloid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human myeloid dendritic cells." ; rdfs:label "myeloid dendritic cell, human" ; rdfs:subClassOf obo:CL_0000782, obo:CL_0001056 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000782 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0001058 obo:IAO_0000115 "A plasmacytoid dendritic cell with the phenotype HLA-DRA-positive, CD123-positive, and CD11c-negative." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "plasmacytoid dendritic cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'plasmacytoid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human plasmacytoid dendritic cells." ; rdfs:label "plasmacytoid dendritic cell, human" ; rdfs:subClassOf obo:CL_0000784, obo:CL_0001056, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001013 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001865 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000784 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0001059 obo:IAO_0000115 "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." ; oboInOwl:hasExactSynonym "common myeloid precursor, CD34-positive" ; oboInOwl:hasRelatedSynonym "CFU-GEMM", "CFU-S", "CMP", "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte", "multipotential myeloid stem cell", "myeloid stem cell", "pluripotent stem cell (bone marrow)" ; a owl:Class ; rdfs:comment "CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative." ; rdfs:label "common myeloid progenitor, CD34-positive" ; rdfs:subClassOf obo:CL_0000049, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007858 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043011 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007858 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002573 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043011 ] ) ] . obo:CL_0001060 obo:IAO_0000115 "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." ; terms:contributor ; oboInOwl:creation_date "2010-01-06T03:43:27Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "hematopoietic oligopotent progenitor cell, lineage-negative" ; rdfs:subClassOf obo:CL_0002032, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002032 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001401 ] ) ] . obo:CL_0001061 obo:IAO_0000115 "A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models." ; terms:contributor ; terms:date "2017-01-30T18:53:32Z"^^xsd:dateTime ; oboInOwl:hasDbXref "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12913" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "https://github.com/obophenotype/cell-ontology/issues/448" ; rdfs:label "abnormal cell" ; rdfs:subClassOf obo:CL_0000000, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000460 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] . obo:CL_0001062 obo:IAO_0000115 "A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasBroadSynonym "TEMRA" ; oboInOwl:hasExactSynonym "CD8+ TEMRA", "CD8-positive TEMRA" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is seen in human but not found in the mouse." ; rdfs:label "effector memory CD8-positive, alpha-beta T cell, terminally differentiated" ; rdfs:subClassOf obo:CL_0000909, obo:CL_4030002, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001017 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000913 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000909 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001017 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0043379 ] ) ] . obo:CL_0001063 obo:IAO_0000115 "An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism." ; terms:contributor ; terms:date "2017-01-30T19:16:26Z"^^xsd:dateTime ; oboInOwl:hasDbXref "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12922" ; oboInOwl:hasRelatedSynonym "tumor cell", "tumour cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "https://github.com/obophenotype/cell-ontology/issues/448" ; rdfs:label "neoplastic cell" ; rdfs:subClassOf obo:CL_0001061, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002011 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001061 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002011 ] ) ] . obo:CL_0001064 obo:IAO_0000115 "A neoplastic cell that is capable of entering a surrounding tissue" ; terms:contributor ; terms:date "2017-01-30T19:39:12Z"^^xsd:dateTime ; oboInOwl:hasDbXref "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12917" ; oboInOwl:hasRelatedSynonym "cancer cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "https://github.com/obophenotype/cell-ontology/issues/448" ; rdfs:label "malignant cell" ; rdfs:subClassOf obo:CL_0001063, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002097 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001063 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002097 ] ) ] . obo:CL_0001065 obo:IAO_0000115 "A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2017-01-30T20:20:48Z"^^xsd:dateTime ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "innate lymphoid cell" ; rdfs:subClassOf obo:CL_0000542, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045087 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000542 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045087 ] ) ] . obo:CL_0001066 obo:IAO_0000115 "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." ; oboInOwl:hasDbXref "BTO:0004911" ; oboInOwl:hasRelatedSynonym "BFU-E", "CFU-E", "blast forming unit erythroid", "burst forming unit erythroid", "colony forming unit erythroid", "erythroid stem cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "erythroid progenitor cell, mammalian" ; rdfs:subClassOf obo:CL_0000038, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001945 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030218 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000038 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001945 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030218 ] ) ] . obo:CL_0001067 obo:IAO_0000115 "An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2017-01-30T20:42:44Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "group 1 innate lymphoid cell" ; rdfs:subClassOf obo:CL_0001065, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001065 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] ) ] . obo:CL_0001068 obo:IAO_0000115 "A group 1 innate lymphoid cell that is non-cytotoxic." ; terms:contributor ; terms:date "2017-01-30T20:54:12Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "ILC1" ; rdfs:subClassOf obo:CL_0001067 . obo:CL_0001069 obo:IAO_0000115 "An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2017-01-30T21:20:08Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "ILC2", "natural helper cell", "nuocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "group 2 innate lymphoid cell" ; rdfs:subClassOf obo:CL_0001065, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032634 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001065 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032634 ] ) ] . obo:CL_0001070 obo:IAO_0000115 "An adipocyte that is beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "MESH:D000069797" ; oboInOwl:hasExactSynonym "beige brown adipocyte", "beige fat cell", "beige/brite adipocyte", "brite adipocyte", "brite cell", "brite fat cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "beige adipocyte" ; rdfs:subClassOf obo:CL_0000136, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001347 ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" . obo:CL_0001071 obo:IAO_0000115 "An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2017-01-31T20:21:26Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "ILC3" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "group 3 innate lymphoid cell" ; rdfs:subClassOf obo:CL_0001065, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003455 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001065 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003455 ] ) ] . obo:CL_0001072 obo:IAO_0000115 "An innate lymphoid cell in the human with the phenotype CD34-negative, CD117-positive, and a precusor to NK cells, ILC2 cells, and ILC3 cells." ; oboInOwl:hasExactSynonym "CD34-negative, CD117-positive ILC", "CD34-negative, CD117-positive ILCP", "CD34-negative, CD117-positive innate lymphoid cell precusor" ; a owl:Class ; rdfs:label "CD34-negative, CD117-positive innate lymphoid cell, human" ; rdfs:subClassOf obo:CL_0001082, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_P28906 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P10721 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001074 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001065 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_P28906 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001501 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P10721 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0001073 obo:IAO_0000115 "An innate lymphoid cell in the human with the phenotype CD34-negative, CD56-positive, CD117-positive.Thie cell type may include precusors to NK cells and ILC3 cells." ; oboInOwl:hasExactSynonym "CD34-negative, CD56-positive, CD117-positive ILC", "CD34-negative, CD56-positive, CD117-positive ILCP", "CD34-negative, CD56-positive, CD117-positive innate lymphoid cell precursor" ; a owl:Class ; rdfs:label "CD34-negative, CD56-positive, CD117-positive innate lymphoid cell, human" ; rdfs:subClassOf obo:CL_0001072, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P13591 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001072 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P10721 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P13591 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0001074 obo:IAO_0000115 "An innate lymphoid cell precursor in the human with the phenotype CD34-positive, CD56-positive, CD117-positive.Thie cell type may include precusors to NK cells and ILC3 cells." ; oboInOwl:hasExactSynonym "CD34-positive, CD56-positive, CD117-positive CILP" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human" ; rdfs:subClassOf obo:CL_0001082, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P10721 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P13591 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P28906 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001065 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001501 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P10721 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P13591 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P28906 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0001075 obo:IAO_0000115 "An innate lymphoid cell in the human with the phenotype KLRG1-positive that is a precusor for ILC2 cells." ; oboInOwl:hasExactSynonym "KLRG1-positive ILC" ; a owl:Class ; rdfs:label "KLRG1-positive innate lymphoid cell, human" ; rdfs:subClassOf obo:CL_0001072, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_Q96E93 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001072 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_Q96E93 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0001076 obo:IAO_0000115 "An innate lymphoid cell in the human with the phenotype NKp46-positive that is a precusor for NK cells and ILC3 cells." ; oboInOwl:hasExactSynonym "NKp46-positive ILC" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "NKp46-positive innate lymphoid cell, human" ; rdfs:subClassOf obo:CL_0001074, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_O76036 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001074 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_O76036 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0001077 obo:IAO_0000115 "An ILC1 cell in the human with the phenotype CD56-negative, IL-7Ralpha-positive, T-bet-positive." ; oboInOwl:hasExactSynonym "innate lymphoid cell 1, human" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "ILC1, human" ; rdfs:subClassOf obo:CL_0001068, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_Q9UL17 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P16871 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001068 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_Q9UL17 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P16871 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0001078 obo:IAO_0000115 "A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "ILC3, human" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "group 3 innate lymphoid cell, human" ; rdfs:subClassOf obo:CL_0001071, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P16871 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001071 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P16871 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0001079 obo:IAO_0000115 "A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive, and NKp44-positive." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "NKp44-positive group 3 innate lymphoid cell, human" ; rdfs:subClassOf obo:CL_0001078, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_O95944 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001071 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_O95944 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P16871 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0001080 obo:IAO_0000115 "A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive, and NKp44-negative." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "NKp44-negative group 3 innate lymphoid cell, human" ; rdfs:subClassOf obo:CL_0001078, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_O95944 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001071 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_O95944 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P16871 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0001081 obo:IAO_0000115 "A group 2 innate lymphoid cell in the human with the phenotype CD25-positive, CD127-positive, CD161-positive, and GATA-3-positive." ; oboInOwl:hasExactSynonym "ILC2, human" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "group 2 innate lymphoid cell, human" ; rdfs:subClassOf obo:CL_0001069, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_P23771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P01589 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P16871 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_Q12918 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_Q9Y5Y4 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001069 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_P23771 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P01589 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P16871 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_Q12918 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_Q9Y5Y4 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0001082 obo:IAO_0000115 "An innate lyphoid cell with an immature phenotype." ; oboInOwl:hasExactSynonym "immature ILC" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "immature innate lymphoid cell" ; rdfs:subClassOf obo:CL_0001065, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001501 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001065 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001501 ] ) ] . obo:CL_0001087 obo:IAO_0000115 "A CD4-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2021-01-18T16:32:44Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "TEMRA" ; oboInOwl:hasExactSynonym "CD4+ TEMRA", "CD4-positive TEMRA" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is seen in human but not found in the mouse." ; rdfs:label "effector memory CD4-positive, alpha-beta T cell, terminally differentiated" ; rdfs:subClassOf obo:CL_0000897, obo:CL_4030002, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001017 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000905 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000897 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001017 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0043379 ] ) ] . obo:CL_0001200 obo:IAO_0000115 "A lymphocyte of B lineage that is CD19-positive." ; terms:contributor ; a owl:Class ; rdfs:comment "Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex)." ; rdfs:label "lymphocyte of B lineage, CD19-positive" ; rdfs:subClassOf obo:CL_0000945, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_40674 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000945 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_40674 ] ) ] . obo:CL_0001201 obo:IAO_0000115 "A B cell that is CD19-positive." ; terms:contributor ; oboInOwl:hasExactSynonym "B lymphocyte, CD19-positive", "B-cell, CD19-positive", "B-lymphocyte, CD19-positive", "CD19+ B cell", "CD19-positive B cell" ; a owl:Class ; rdfs:label "B cell, CD19-positive" ; rdfs:subClassOf obo:CL_0000236, obo:CL_0001200 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001200 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0019724 ] ) ] . obo:CL_0001202 obo:IAO_0000115 "A plasmablast that is CD86-positive." ; terms:contributor ; oboInOwl:hasBroadSynonym "CD86-positive, CD20-negative plasmablast" ; oboInOwl:hasExactSynonym "CD86+ plasmablast" ; a owl:Class ; rdfs:label "CD86-positive plasmablast" ; rdfs:subClassOf obo:CL_0000980, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001412 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000980 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001412 ] ) ] . obo:CL_0001203 obo:IAO_0000115 "A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "CD8-positive, alpha-beta memory T lymphocyte, CD45RO-positive", "CD8-positive, alpha-beta memory T-cell, CD45RO-positive", "CD8-positive, alpha-beta memory T-lymphocyte, CD45RO-positive" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "CD8-positive, alpha-beta memory T cell, CD45RO-positive" ; rdfs:subClassOf obo:CL_0000909, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000906 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001307 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001381 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000909 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0043379 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001381 ] ) ] . obo:CL_0001204 obo:IAO_0000115 "CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." ; oboInOwl:hasExactSynonym "CD4-positive, alpha-beta memory T lymphocyte, CD45RO-positive", "CD4-positive, alpha-beta memory T-cell, CD45RO-positive", "CD4-positive, alpha-beta memory T-lymphocyte, CD45RO-positive" ; a owl:Class ; rdfs:label "CD4-positive, alpha-beta memory T cell, CD45RO-positive" ; rdfs:subClassOf obo:CL_0000897, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000896 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001307 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001381 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000897 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0043379 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001381 ] ) ] . obo:CL_0001658 oboInOwl:hasDbXref "FBbt:00004230" ; a owl:Class ; rdfs:label "visual pigment cell (sensu Nematoda and Protostomia)" ; rdfs:subClassOf obo:CL_0000149, obo:CL_0000341 . obo:CL_0002000 obo:IAO_0000115 "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T10:14:16Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "c- Kit-positive erythroid progenitor cell" ; a owl:Class ; rdfs:comment "Markers found on mouse cells." ; rdfs:label "Kit-positive erythroid progenitor cell" ; rdfs:subClassOf obo:CL_0001066, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0033001 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001833 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001865 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000009127 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001345 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002006 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001066 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0033001 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001833 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001865 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000009127 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001345 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] ) ] . obo:CL_0002001 obo:IAO_0000115 "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." ; terms:contributor ; oboInOwl:creation_date "2010-01-13T03:19:22Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population." ; rdfs:label "CD34-positive, CD38-positive granulocyte monocyte progenitor" ; rdfs:subClassOf obo:CL_0000557, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001026 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000557 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001865 ] ) ] . obo:CL_0002002 obo:IAO_0000115 "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." ; terms:contributor ; oboInOwl:creation_date "2010-01-13T03:19:28Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are found on mouse cells." ; rdfs:label "Kit-positive granulocyte monocyte progenitor" ; rdfs:subClassOf obo:CL_0000557, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001206 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001843 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001023 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0033001 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001479 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000557 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001206 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001843 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0033001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001479 ] ) ] . obo:CL_0002003 obo:IAO_0000115 "An erythroid progenitor cell that is CD34-positive and is GlyA-negative." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T10:14:30Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:83517" ; a owl:Class ; rdfs:comment "Cell markers associated with human cells." ; rdfs:label "CD34-positive, GlyA-negative erythroid progenitor cell" ; rdfs:subClassOf obo:CL_0001066, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001460 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002005 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001066 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] ) ] . obo:CL_0002004 obo:IAO_0000115 "A proerythoblast that is CD34-negative and GlyA-negative." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T10:31:50Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Cell surface markers are associated with human cells." ; rdfs:label "CD34-negative, GlyA-negative proerythroblast" ; rdfs:subClassOf obo:CL_0000547, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001460 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002003 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000547 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001460 ] ) ] . obo:CL_0002005 obo:IAO_0000115 "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." ; terms:contributor ; oboInOwl:creation_date "2010-01-13T03:43:10Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are associated with human cell type." ; rdfs:label "CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell" ; rdfs:subClassOf obo:CL_0000050, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001865 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000050 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002006 obo:IAO_0000115 "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." ; terms:contributor ; oboInOwl:creation_date "2010-01-13T03:43:12Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell" ; rdfs:subClassOf obo:CL_0000050, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001479 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001843 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0033001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000050 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001479 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001843 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0033001 ] ) ] . obo:CL_0002007 obo:IAO_0000115 "A lineage marker-negative, CD34-positive, IL5r-alpha-positive, and Sca1-negative eosinophil progenitor cell." ; terms:contributor ; oboInOwl:creation_date "2010-01-14T03:25:15Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are found on mouse cells." ; rdfs:label "Kit-low, CD34-positive eosinophil progenitor cell" ; rdfs:subClassOf obo:CL_0000611, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002002 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002065 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000611 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002065 ] ) ] . obo:CL_0002008 obo:IAO_0000115 "A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell." ; terms:contributor ; oboInOwl:creation_date "2010-01-14T03:25:17Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are associated with human cells." ; rdfs:label "CD34-positive, CD38-positive eosinophil progenitor cell" ; rdfs:subClassOf obo:CL_0000611, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000611 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001865 ] ) ] . obo:CL_0002009 obo:IAO_0000115 "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." ; terms:contributor ; oboInOwl:creation_date "2010-01-19T02:51:58Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "MDP" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "macrophage dendritic cell progenitor" ; rdfs:subClassOf obo:CL_0000763, obo:CL_0002032, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000557 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030224 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043011 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002032 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030224 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043011 ] ) ] . obo:CL_0002010 obo:IAO_0000115 "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." ; oboInOwl:creation_date "2010-01-19T03:39:30Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "pre-conventional dendritic cell" ; rdfs:subClassOf obo:CL_0000763, obo:CL_0002031, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042613 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001013 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001968 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002001 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001029 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002031 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001968 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002001 ] ) ] . obo:CL_0002011 obo:IAO_0000115 "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." ; terms:contributor ; oboInOwl:creation_date "2010-01-26T02:43:40Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "murine MDP" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Kit-positive macrophage dendritic cell progenitor" ; rdfs:subClassOf obo:CL_0002009, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001206 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002001 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002002 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002065 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002009 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001206 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002065 ] ) ] . obo:CL_0002012 obo:IAO_0000115 "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T10:31:56Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Kit-low proerythroblast" ; rdfs:subClassOf obo:CL_0000547, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002981 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002000 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001945 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002065 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000547 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001945 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002065 ] ) ] . obo:CL_0002013 obo:IAO_0000115 "A basophilic erythroblast that is GlyA-positive." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T10:41:15Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are associated with human cells." ; rdfs:label "GlyA-positive basophilic erythroblast" ; rdfs:subClassOf obo:CL_0000549, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001460 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002004 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000549 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001460 ] ) ] . obo:CL_0002014 obo:IAO_0000115 "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T10:41:22Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Cell surface markers are associated with mouse cells." ; rdfs:label "Kit-negative, Ly-76 high basophilic erythroblast" ; rdfs:subClassOf obo:CL_0000549, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002981 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000549 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002981 ] ) ] . obo:CL_0002015 obo:IAO_0000115 "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T10:53:11Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "late basophilic and polychromatophilic erythroblast" ; a owl:Class ; rdfs:label "Kit-negative, Ly-76 high polychromatophilic erythroblast" ; rdfs:subClassOf obo:CL_0000550, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002014 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002981 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000550 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002981 ] ) ] . obo:CL_0002016 obo:IAO_0000115 "A polychromatiic erythroblast that is Gly-A-positive and CD71-low." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T10:53:16Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Cell surface markers are associated with human cells." ; rdfs:label "CD71-low, GlyA-positive polychromatic erythroblast" ; rdfs:subClassOf obo:CL_0000550, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001460 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002013 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001945 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000550 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001945 ] ) ] . obo:CL_0002017 obo:IAO_0000115 "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T11:04:15Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Cell surface markers associated with mouse cells." ; rdfs:label "Kit-negative, Ly-76 high orthochromatophilic erythroblasts" ; rdfs:subClassOf obo:CL_0000552, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002981 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001945 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000552 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001945 ] ) ] . obo:CL_0002018 obo:IAO_0000115 "An erythroblast that is GlyA-positive and CD71-negative." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T11:04:21Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers associated with human cells." ; rdfs:label "CD71-negative, GlyA-positive orthochromatic erythroblast" ; rdfs:subClassOf obo:CL_0000552, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001945 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001460 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002016 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000552 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001945 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001460 ] ) ] . obo:CL_0002019 obo:IAO_0000115 "A reticulocyte that is Ly76-high and is Kit-negative." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T11:37:00Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Marker associated with mouse cells." ; rdfs:label "Ly-76 high reticulocyte" ; rdfs:subClassOf obo:CL_0002422, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002981 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002422 [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002981 ] ) ] . obo:CL_0002020 obo:IAO_0000115 "A reticulocyte that is GlyA-positive." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T11:48:25Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers is associated with human cells." ; rdfs:label "GlyA-positive reticulocytes" ; rdfs:subClassOf obo:CL_0002422, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001460 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002018 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002422 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001460 ] ) ] . obo:CL_0002021 obo:IAO_0000115 "An enucleate erythrocyte that is GlyA-positive." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T11:51:22Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Marker is associated with human cell types." ; rdfs:label "GlyA-positive erythrocyte" ; rdfs:subClassOf obo:CL_0000595, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001460 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002020 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000595 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001460 ] ) ] . obo:CL_0002022 obo:IAO_0000115 "An enucleate erythrocyte that is Lyg-76-high." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T11:51:27Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Marker is associated with mouse cell types." ; rdfs:label "Ly-76 high positive erythrocyte" ; rdfs:subClassOf obo:CL_0000595, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002019 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002981 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000595 [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002981 ] ) ] . obo:CL_0002023 obo:IAO_0000115 "A megakaroycotye progenitor cell that is CD34-positive, CD41-positive and CD42-positive on the cell surface." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T02:39:09Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are associated with human cell type." ; rdfs:label "CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell" ; rdfs:subClassOf obo:CL_0000553, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001907 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009127 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002025 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000553 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001907 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009127 ] ) ] . obo:CL_0002024 obo:IAO_0000115 "A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T02:39:15Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Kit-positive megakaryocyte progenitor cell" ; rdfs:subClassOf obo:CL_0000553, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001833 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000005178 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002006 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001479 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001483 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000553 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001833 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000005178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001479 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001483 ] ) ] . obo:CL_0002025 obo:IAO_0000115 "A megakaryocyte progenitor cell that is CD34-positive, CD41-positive, and CD42-negative." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T03:52:47Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are commonly associated with human cells." ; rdfs:label "CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell" ; rdfs:subClassOf obo:CL_0000553, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001907 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009127 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002005 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000553 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001907 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009127 ] ) ] . obo:CL_0002026 obo:IAO_0000115 "A megakaryocyte progenitor cell that is CD34-negative, CD41-positive and CD42-positive." ; terms:contributor ; oboInOwl:creation_date "2010-04-26T03:59:22Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are commonly associated with human cells." ; rdfs:label "CD34-negative, CD41-positive, CD42-positive megakaryocyte cell" ; rdfs:subClassOf obo:CL_0000556, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001907 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009127 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002023 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000556 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001907 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009127 ] ) ] . obo:CL_0002027 obo:IAO_0000115 "A megakaryocyte cell with is CD9-positive and CD41-positive." ; terms:contributor ; oboInOwl:creation_date "2010-04-27T10:39:07Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are commonly associated with mouse cells." ; rdfs:label "CD9-positive, CD41-positive megakaryocyte cell" ; rdfs:subClassOf obo:CL_0000556, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000005178 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009127 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002024 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000556 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000005178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009127 ] ) ] . obo:CL_0002028 obo:IAO_0000115 "A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa" ; terms:contributor ; oboInOwl:creation_date "2010-04-27T12:46:33Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "BMCP" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low." ; rdfs:label "basophil mast progenitor cell" ; rdfs:subClassOf obo:CL_0000763, obo:CL_0002191, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007858 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000007431 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000016401 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001867 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000557 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030221 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0060374 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000839 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007858 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000007431 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000016401 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030221 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0060374 ] ) ] . obo:CL_0002029 obo:IAO_0000115 "A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low." ; terms:contributor ; oboInOwl:creation_date "2010-04-27T01:22:19Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Fc-epsilon RIalpha-low mast cell progenitor" ; rdfs:subClassOf obo:CL_0000831, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002044 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000831 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009143 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000007431 ] ) ] . obo:CL_0002030 obo:IAO_0000115 "A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high." ; terms:contributor ; oboInOwl:creation_date "2010-04-27T01:22:32Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Fc-epsilon RIalpha-high basophil progenitor cell" ; rdfs:subClassOf obo:CL_0000613, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002044 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000613 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000007431 ] ) ] . obo:CL_0002031 obo:IAO_0000115 "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." ; terms:contributor ; oboInOwl:creation_date "2010-01-06T03:43:20Z"^^xsd:dateTime ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:label "hematopoietic lineage restricted progenitor cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000255, obo:CL_0008001, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001400 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002032 ] ; owl:disjointWith obo:CL_0002032 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000988 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001400 ] ) ] ; skos:prefLabel "hematopoietic lineage restricted progenitor cell" . obo:CL_0002032 obo:IAO_0000115 "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." ; terms:contributor ; oboInOwl:creation_date "2010-01-06T03:43:27Z"^^xsd:dateTime ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset ; a owl:Class ; rdfs:comment "This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060)." ; rdfs:label "hematopoietic oligopotent progenitor cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000255, obo:CL_0008001, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001401 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000837 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000988 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001401 ] ) ] ; skos:prefLabel "hematopoietic oligopotent progenitor cell" . obo:CL_0002033 obo:IAO_0000115 "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." ; terms:contributor ; oboInOwl:creation_date "2010-01-08T09:19:25Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "ST stem cell", "ST-HSC" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low." ; rdfs:label "short term hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0001008, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002001 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002034 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001008 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001833 ] ) ] . obo:CL_0002034 obo:IAO_0000115 "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." ; terms:contributor ; oboInOwl:creation_date "2010-01-08T09:19:28Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "LT stem cell", "LT-HSC" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "long term hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0001008, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002001 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001843 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001008 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001833 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001843 ] ) ] . obo:CL_0002035 obo:IAO_0000115 "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." ; terms:contributor ; oboInOwl:creation_date "2010-01-08T11:16:33Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Slamf1-negative multipotent progenitor cell" ; rdfs:subClassOf obo:CL_0000837, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001833 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002001 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002036 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000837 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001833 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ] ) ] . obo:CL_0002036 obo:IAO_0000115 "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." ; terms:contributor ; oboInOwl:creation_date "2010-01-08T11:16:35Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "KSL cell" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Slamf1-positive multipotent progenitor cell" ; rdfs:subClassOf obo:CL_0000837, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001833 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002033 ] ; owl:disjointWith obo:CL_0002043 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000837 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001833 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ] ) ] . obo:CL_0002037 obo:IAO_0000115 "Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive." ; terms:contributor ; oboInOwl:creation_date "2009-10-20T02:20:43Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "memory alpha beta IEL" ; a owl:Class ; rdfs:label "CD2-positive, CD5-positive, CD44-positive alpha-beta intraepithelial T cell" ; rdfs:subClassOf obo:CL_0000793, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001083 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001839 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000793 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001839 ] ) ] . obo:CL_0002038 obo:IAO_0000115 "A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2009-10-29T04:01:27Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "T(FH)", "Tfh" ; oboInOwl:hasRelatedSynonym "follicular B helper T cell", "follicular T cell", "follicular T-cell", "follicular T-helper cell", "follicular helper T cell", "follicular helper T-cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "T follicular helper cell" ; rdfs:subClassOf obo:CL_0000492, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003450 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001209 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001860 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001919 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045830 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0051024 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000492 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003450 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001209 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001860 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001919 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045830 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0051024 ] ) ] . obo:CL_0002039 obo:IAO_0000115 "A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell." ; terms:contributor ; oboInOwl:creation_date "2009-10-29T04:09:16Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "immature NK T cell stage I" ; rdfs:subClassOf obo:CL_0000914, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001307 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001874 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000025402 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000914 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001874 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000025402 ] ) ] . obo:CL_0002040 obo:IAO_0000115 "A CD24-low, CD44-negative, NK1.1-negative NK T cell." ; terms:contributor ; oboInOwl:creation_date "2009-10-29T04:13:43Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "NKT.44-NK1.1-.Th" ; a owl:Class ; rdfs:comment "NKT.44-NK1.1-.Th was assigned as an exact synonym based on sorting strategy displayed at immgene.org." ; rdfs:label "immature NK T cell stage II" ; rdfs:subClassOf obo:CL_0000914, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001307 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001874 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002039 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000914 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001874 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0002041 obo:IAO_0000115 "A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell." ; terms:contributor ; oboInOwl:creation_date "2009-10-29T04:14:48Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "NKT.44+.NK1.1-.Th" ; a owl:Class ; rdfs:label "immature NK T cell stage III" ; rdfs:subClassOf obo:CL_0000914, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001874 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002040 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001008 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000914 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001874 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001008 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0002042 obo:IAO_0000115 "A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2009-10-29T04:17:38Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "NKT.44+.NK1.1-.Th" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "immature NK T cell stage IV" ; rdfs:subClassOf obo:CL_0000914, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001874 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002041 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001008 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000914 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001874 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001008 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0002043 obo:IAO_0000115 "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." ; terms:contributor ; oboInOwl:creation_date "2010-01-12T11:14:15Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Cell markers are associated with human hematopoietic multipotent progenitor cells." ; rdfs:label "CD34-positive, CD38-negative multipotent progenitor cell" ; rdfs:subClassOf obo:CL_0000837, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001843 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001024 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000837 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001843 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] ) ] . obo:CL_0002044 obo:IAO_0000115 "A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative." ; terms:contributor ; oboInOwl:creation_date "2010-04-27T01:22:38Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Kit-positive, integrin beta7-high basophil mast progenitor cell" ; rdfs:subClassOf obo:CL_0002028, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001479 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000009143 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002028 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001479 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000009143 ] ) ] . obo:CL_0002045 obo:IAO_0000115 "A pro-B cell that is CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive." ; terms:contributor ; oboInOwl:creation_date "2010-04-28T10:50:07Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "fraction A" ; oboInOwl:hasRelatedSynonym "pre pro B cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Markers associated with mouse cells." ; rdfs:label "fraction A pre-pro B cell" ; rdfs:subClassOf obo:CL_0000826, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002039 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002980 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000826 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002039 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002980 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0002046 obo:IAO_0000115 "A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage." ; terms:contributor ; oboInOwl:creation_date "2010-04-28T11:19:11Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Markers are commonly associated with human cells. These cells are also reportedly CD21-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive." ; rdfs:label "early pro-B cell" ; rdfs:subClassOf obo:CL_0000826, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001338 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0071707 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0035369 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001288 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001898 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000826 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0071707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0035369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001288 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001898 ] ) ] . obo:CL_0002047 obo:IAO_0000115 "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative." ; terms:contributor ; oboInOwl:creation_date "2010-04-28T11:56:21Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "Fr. B", "Fraction B" ; a owl:Class ; rdfs:comment "Markers are commonly associated with mouse cells. These cells are also reportedly RAG1-positive and RAG2-positive." ; rdfs:label "fraction B precursor B cell" ; rdfs:subClassOf obo:CL_0002400, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002039 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002045 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002400 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002039 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0002048 obo:IAO_0000115 "A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive." ; terms:contributor ; oboInOwl:creation_date "2010-04-28T12:06:06Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Late pro-B cells are also reportedly CD10-positive, CD20-negative, CD21-negative, and TdT-positive. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive." ; rdfs:label "late pro-B cell" ; rdfs:subClassOf obo:CL_0000817, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001288 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002046 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001002 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000817 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001288 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001002 ] ) ] . obo:CL_0002049 obo:IAO_0000115 "A precursor B cell that is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain." ; terms:contributor ; oboInOwl:creation_date "2010-04-28T02:04:01Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "Fraction C" ; a owl:Class ; rdfs:label "fraction C precursor B cell" ; rdfs:subClassOf obo:CL_0002400, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001858 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001859 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0071707 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002039 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000003457 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000003460 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002047 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002400 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001858 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001859 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0071707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002039 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000003457 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000003460 ] ) ] . obo:CL_0002050 obo:IAO_0000115 "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive." ; terms:contributor ; oboInOwl:creation_date "2010-04-28T02:13:46Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "Fr. C'", "Fraction C-prime" ; a owl:Class ; rdfs:label "fraction C' precursor B cell" ; rdfs:subClassOf obo:CL_0000817, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0035369 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002039 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002049 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000817 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0035369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002039 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0002051 obo:IAO_0000115 "A pre-BCR positive B cell that is CD38-high." ; terms:contributor ; oboInOwl:creation_date "2010-04-28T02:27:47Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "large pre-B cell type I" ; a owl:Class ; rdfs:comment "Markers are associated with human cells." ; rdfs:label "CD38-high pre-BCR positive cell" ; rdfs:subClassOf obo:CL_0000952, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001288 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002048 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001408 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000952 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001288 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002052 obo:IAO_0000115 "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive." ; terms:contributor ; oboInOwl:creation_date "2010-04-28T02:55:16Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "Fr. D" ; oboInOwl:hasExactSynonym "fraction D pre-B cell" ; a owl:Class ; rdfs:comment "Fraction D precursor B cells are also reportedly CD24-positive and sIgD-negative." ; rdfs:label "fraction D precursor B cell" ; rdfs:subClassOf obo:CL_0002400, [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0071708 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0035369 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002039 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002050 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000817 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0071708 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0035369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002039 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001879 ] ) ] . obo:CL_0002053 obo:IAO_0000115 "A small pre-B cell that is CD22-positive and CD38-low." ; terms:contributor ; oboInOwl:creation_date "2010-04-28T03:04:48Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "small pre-B cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Markers are associated with human cell. RAG expression maybe diminishing." ; rdfs:label "CD22-positive, CD38-low small pre-B cell" ; rdfs:subClassOf obo:CL_0000954, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001288 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002051 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001408 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000954 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001288 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002054 obo:IAO_0000115 "An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive." ; terms:contributor ; oboInOwl:creation_date "2010-04-28T03:13:47Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers associated with mouse cells. These cells are also reportedly sIgD-negative." ; rdfs:label "fraction E immature B cell" ; rdfs:subClassOf obo:CL_0000816, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002052 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000816 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001879 ] ) ] . obo:CL_0002055 obo:IAO_0000115 "An immature B cell that is CD38-negative, CD10-low, CD21-low, and CD22-high." ; terms:contributor ; oboInOwl:creation_date "2010-04-28T03:19:14Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are associated with human cell type." ; rdfs:label "CD38-negative immature B cell" ; rdfs:subClassOf obo:CL_0000816, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002053 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001288 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001338 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001898 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000816 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001288 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001898 ] ) ] . obo:CL_0002056 obo:IAO_0000115 "A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative." ; terms:contributor ; oboInOwl:creation_date "2010-04-30T03:01:48Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "fraction F mature B cell" ; rdfs:subClassOf obo:CL_0000822, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001880 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002037 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001338 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002054 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001880 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001338 ] ) ] . obo:CL_0002057 obo:IAO_0000115 "A classical monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive." ; terms:contributor ; oboInOwl:creation_date "2010-06-05T08:25:41Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "CD16- monocyte", "CD16-negative monocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'CD16- monocyte'. The markers used in the definition are associated with human monocytes." ; rdfs:label "CD14-positive, CD16-negative classical monocyte" ; rdfs:subClassOf obo:CL_0000860, obo:CL_0001054, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001483 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001465 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001925 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000860 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001465 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001925 ] ) ] . obo:CL_0002058 obo:IAO_0000115 "A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive." ; terms:contributor ; oboInOwl:creation_date "2010-06-05T08:25:44Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. Also, this cell-type is sometimes described as being Gr1-negative." ; rdfs:label "Gr1-low non-classical monocyte" ; rdfs:subClassOf obo:CL_0000875, obo:CL_0002398, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001014 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002398 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001199 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002980 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000875 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001206 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001199 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002980 ] ) ] . obo:CL_0002059 obo:IAO_0000115 "A conventional thymic dendritic cell that is CD8-alpha-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-06-07T02:48:36Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "CD8alpha-alpha-positive thymic conventional dendritic cell", "DC.8+.Th" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "CD8-alpha-positive thymic conventional dendritic cell" ; rdfs:subClassOf obo:CL_0000941, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001084 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000941 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001084 ] ) ] . obo:CL_0002060 obo:IAO_0000115 "A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes." ; terms:contributor ; oboInOwl:creation_date "2010-06-22T10:46:12Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "melanophage" ; rdfs:subClassOf obo:CL_0000864, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002097 ] . obo:CL_0002061 obo:IAO_0000115 "A T-helper cell that is characterized by secreting interleukin 9 and responding to helminth infections. This cell-type can derives from Th2 cells in the presence of TGF-beta and IL-4. Th2 cytokine production is surpressed." ; terms:contributor ; oboInOwl:creation_date "2010-06-22T11:18:44Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "T helper cells type 9", "T(H)-9 cell", "Th9" ; a owl:Class ; rdfs:label "T-helper 9 cell" ; rdfs:subClassOf obo:CL_0000492, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000008982 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002215 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032638 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000492 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000008982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002215 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032638 ] ) ] . obo:CL_0002062 obo:IAO_0000115 "A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-06-23T04:37:54Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0000780", "FMA:62500" ; oboInOwl:hasExactSynonym "lung type 1 cells", "membranous pneumocytes", "pulmonary alveolar type I cell", "small alveolar cells", "squamous alveolar cell", "squamous alveolar lining cell", "type 1 alveolar epithelial cells", "type 1 pneumocyte", "type I alveolar cells", "type I alveolar epithelial cells", "type I pneumocyte" ; oboInOwl:hasRelatedSynonym "AT1", "ATI" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The marker set AGER can identify the Human cell type pulmonary alveolar type 1 cell in the lung with a confidence of 0.85 (NS-Forest FBeta value)." ; rdfs:label "pulmonary alveolar type 1 cell" ; rdfs:subClassOf obo:CL_0000076, obo:CL_0000322, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007585 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000008 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000322 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007585 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" . obo:CL_0002063 obo:IAO_0000115 "A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants via specialized organelles called alveolar lamellar bodies. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, has a rounded apical surface that projects above the level of the surrounding epithelium, and its free surface is covered by short microvilli." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-06-24T12:04:13Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0000538", "FMA:62501" ; oboInOwl:hasExactSynonym "cuboidal type II cell", "granular pneumocyte", "great alveolar cell", "lung type 2 cell", "type 2 alveolar epithelial cell", "type 2 alveolocyte", "type 2 pneumocyte", "type II alveolar cell", "type II alveolar epithelial cell", "type II alveolocyte", "type II pneumocyte" ; oboInOwl:hasRelatedSynonym "AT2", "ATII", "TII", "lung type II cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The marker set SFTPA1 can identify the Human cell type pulmonary alveolar type 2 cell in the lung with a confidence of 0.95 (NS-Forest FBeta value)." ; rdfs:label "pulmonary alveolar type 2 cell" ; rdfs:subClassOf obo:CL_0000157, obo:CL_0000322, obo:CL_0008055, obo:CL_1000272, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0097208 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001872 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_4040003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000009 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000322 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032940 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043129 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" . obo:CL_0002064 obo:IAO_0000115 "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Pancreatic acinar cells are the functional units of the exocrine pancreas. These cells are structurally arranged in small clusters - or acini - with a small central lumen, and their primary function is to produce and secrete enzymes that facilitate digestion of proteins, carbohydrates, and fats within the small intestine. Some of the most important digestive enzymes synthesized by the pancreatic acinar cells include amylase, which digests carbohydrates, lipase, which breaks down fats, and several proteases such as trypsin and chymotrypsin which are vital for the digestion of proteins. Importantly, these enzymes are produced as proenzymes or zymogens to avoid autolysis, or the breakdown of the pancreas itself. The release of these enzymes by the pancreatic acinar cells is strictly regulated by hormones and neurochemicals. Cholecystokinin (CCK) released from the enteroendocrine cells in the duodenum cause the release of these enzymes. Moreover, acinar cells also respond to another hormone, secretin, by releasing bicarbonate-rich fluid which helps to neutralize the gastric acid in the duodenum. Dysregulation in the function of pancreatic acinar cells can lead to severe health issues, including pancreatitis, which is characterized by inflammatory damage to the organ due to the premature activation of digestive enzymes. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-06-24T03:16:29Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0000028", "CALOHA:TS-0737", "FMA:63032", "ZFA:0005739" ; oboInOwl:hasExactSynonym "acinar cell of pancreas" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreatic acinar cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002064" ; rdfs:subClassOf obo:CL_0000622, obo:CL_1001599, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001263 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042589 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000622 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001263 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-pancreatic-acinus/v1.2/assets/2d-ftu-pancreas-pancreatic-acinus.png" . obo:CL_0002065 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000577 ; a owl:Class ; owl:deprecated true . obo:CL_0002066 obo:IAO_0000115 "A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane." ; terms:contributor ; oboInOwl:creation_date "2010-06-28T08:24:30Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:14118" ; oboInOwl:hasExactSynonym "Kultschitzky cell of bronchiole", "bronchiolar Kulchitsky cell", "respiratory enterochromaffin cell" ; oboInOwl:hasRelatedSynonym "P cell" ; a owl:Class ; rdfs:label "Feyrter cell" ; rdfs:subClassOf obo:CL_0000165 . obo:CL_0002067 obo:IAO_0000115 "An enteroendocrine cell that produces glucagon." ; terms:contributor ; terms:description """Type A enteroendocrine cells, also known as alpha cells or A cells, are a species of endocrine cells primarily located in the pancreatic islets of Langerhans; they have also been identified within the lining of the stomach. Functionally, these cells are pivotal in glucose metabolism and homeostasis, accounting for about 20% of the total population of cells in the pancreatic islets. The primary role of type A enteroendocrine cells involves the synthesis, storage, and secretion of the peptide hormone glucagon, which is critical in energy regulation throughout the body. In response to a decrease in blood glucose levels, the pancreatic A cells are stimulated to secrete glucagon into the bloodstream. Glucagon acts on its target cells, mainly in the liver, to stimulate glycogenolysis and gluconeogenesis processes, thereby increasing blood glucose levels back to normal. In this way, pancreatic A cells play an integral role in maintaining glucose homeostasis and preventing hypoglycemia. Pancreatic A cells also participate in the local regulation of islet activities as glucagon acts through glucagon receptors on A, B and D type cells within the islets. Recent studies have also shown that Pancreatic A cells play a role in the generation and regeneration of B type cells. Following beta cell injuries pancreatic A cells increase in numbers and produce Glucagon-like peptide-1 (GLP-1), which increases the proliferation and cytoprotection of beta cells. In response to extreme injury of B type cells pancreatic A cells can transform (transdifferentiate) into functioning B type cells. Until recently, glucagon has been considered a pancreas-specific hormone; however, extrapancreatic glucagon has been reported in patients who had undergone complete, and glucagon-positive cells been identified in the human stomach, indicating that Type A enteroendocrine cells are not restricted to the pancreas. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-09-10T10:48:54Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62939" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type A enteroendocrine cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002067" ; rdfs:subClassOf obo:CL_0000164, obo:CL_0000170 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000164 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070091 ] ) ] . obo:CL_0002068 obo:IAO_0000115 "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-06-28T08:36:15Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0001032", "FMA:14146" ; oboInOwl:hasExactSynonym "Purkinje cell fiber", "Purkinje muscle cell", "myocytus conducens cardiacus" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "Purkinje myocyte" ; rdfs:subClassOf obo:CL_0002086 . obo:CL_0002069 obo:IAO_0000115 "Mostly cylindrical, resemble Type 1 in their contents and the presence of a kinocilium and stereocilium apically; much greater variation in size, some almost span the entire thickness of the sensory epithelium, while others are smaller than Type 1; receive multiple efferent nerve boutons around their bases as well as afferent endings, which are small expansions rather than chalices." ; terms:contributor ; oboInOwl:creation_date "2010-06-29T09:58:13Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:67909" ; oboInOwl:hasExactSynonym "type 2 vestibular hair cell", "type 2 vestibular sensory cell", "type II hair cell" ; a owl:Class ; rdfs:label "type II vestibular sensory cell" ; rdfs:subClassOf obo:CL_0000609 . obo:CL_0002070 obo:IAO_0000115 "Bottle-shaped with narrow neck; broad, rounded basal portion where nucleus is located; stereocilia and a single kinocilium is present apically; receive nerve bouton at their base from an afferent cup-shaped (chalice or calyx) nerve ending." ; terms:contributor ; oboInOwl:creation_date "2010-06-29T09:58:19Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62352" ; oboInOwl:hasExactSynonym "type 1 vestibular hair cell", "type 1 vestibular sensory cell", "type I hair cell" ; a owl:Class ; rdfs:label "type I vestibular sensory cell" ; rdfs:subClassOf obo:CL_0000609 . obo:CL_0002071 obo:IAO_0000115 "Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-06-29T11:07:25Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "columnar cell" ; oboInOwl:hasDbXref "BTO:0002484", "FMA:63638", "FMA:66771" ; oboInOwl:hasExactSynonym "columnar cell of the colon", "vacuolar absorptive cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "enterocyte of epithelium of large intestine" ; rdfs:subClassOf obo:CL_0000584, obo:CL_0002253 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000584 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001278 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/large-intestine-crypt-lieberkuhn/v1.2/assets/2d-ftu-large-intestine-crypt-lieberkuhn.png" . obo:CL_0002072 obo:IAO_0000115 "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." ; terms:contributor ; oboInOwl:creation_date "2010-06-29T11:41:37Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "pacemaker cell" ; oboInOwl:hasDbXref "BTO:0004190", "FMA:67101" ; oboInOwl:hasExactSynonym "P cell", "cardiac pacemaker cell", "myocytus nodalis" ; a owl:Class ; rdfs:label "nodal myocyte" ; rdfs:subClassOf obo:CL_0002086 . obo:CL_0002073 obo:IAO_0000115 "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." ; terms:contributor ; oboInOwl:creation_date "2010-06-29T02:39:32Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:67142" ; a owl:Class ; rdfs:label "transitional myocyte" ; rdfs:subClassOf obo:CL_0002086 . obo:CL_0002074 obo:IAO_0000115 "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." ; terms:contributor ; oboInOwl:creation_date "2010-06-29T11:50:47Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:67111" ; a owl:Class ; rdfs:label "myocardial endocrine cell" ; rdfs:subClassOf obo:CL_0000163, obo:CL_0002086 . obo:CL_0002075 obo:IAO_0000115 "A rare type of columnar epithelial cell that is part of the tracheobronchial epithelium. This cell is characterized by a distinctive tuft of apical microvilli, which extends into the cytoplasm, and a pear-shaped morphology, broad at the base and tapering to a narrow apex. It plays vital roles in chemosensation, producing cytokines like IL-25, and enhancing mucociliary clearance through acetylcholine release to support mucus movement and airway defense." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-06-29T03:22:46Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "pulmonary brush cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "The marker set POU2F3, HOMER3, MYB can identify the Human cell type brush cell of tracheobronchial tree in the lung with a confidence of 0.56 (NS-Forest FBeta value)." ; rdfs:label "brush cell of tracheobronchial tree" ; rdfs:subClassOf obo:CL_0000075, obo:CL_0002202, obo:CL_0002204, [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000061 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008397 ] ) ] . obo:CL_0002076 obo:IAO_0000115 "An epithelial cell derived from endoderm." ; terms:contributor ; oboInOwl:creation_date "2010-06-29T03:38:14Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:69075", "ZFA:0009383" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "endo-epithelial cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000223 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000223 ] ) ] ; skos:prefLabel "endo-epithelial cell" . obo:CL_0002077 obo:IAO_0000115 "An epithelial cell derived from ectoderm." ; terms:contributor ; oboInOwl:creation_date "2010-06-29T03:38:22Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:69074", "ZFA:0009385" ; a owl:Class ; rdfs:label "ecto-epithelial cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000221 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000221 ] ) ] ; skos:prefLabel "ecto-epithelial cell" . obo:CL_0002078 obo:IAO_0000115 "Epithelial cell derived from mesoderm or mesenchyme." ; terms:contributor ; oboInOwl:creation_date "2010-06-29T03:49:14Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:69076", "ZFA:0009388" ; oboInOwl:hasExactSynonym "epithelial mesenchymal cell" ; a owl:Class ; rdfs:label "meso-epithelial cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000222 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000222 ] ) ] . obo:CL_0002079 obo:IAO_0000115 "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-06-30T08:49:43Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:63099", "ZFA:0009380" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreatic ductal cell" ; rdfs:subClassOf obo:CL_0000069, obo:CL_1001433, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001064 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0015106 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000083 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001064 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0015106 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-intercalated-duct/v1.2/assets/2d-ftu-pancreas-intercalated-duct.png", "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-pancreatic-acinus/v1.2/assets/2d-ftu-pancreas-pancreatic-acinus.png" . obo:CL_0002080 obo:IAO_0000115 "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-06-30T08:49:52Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62455", "ZFA:0005740" ; oboInOwl:hasExactSynonym "centroacinar cell of Langerhans", "pancreatic centroacinar cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreatic centro-acinar cell" ; rdfs:subClassOf obo:CL_1001433, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001263 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0015106 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000083 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001263 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0015106 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-intercalated-duct/v1.2/assets/2d-ftu-pancreas-intercalated-duct.png", "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-pancreatic-acinus/v1.2/assets/2d-ftu-pancreas-pancreatic-acinus.png" . obo:CL_0002081 obo:IAO_0000115 "This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery." ; terms:contributor ; oboInOwl:creation_date "2010-06-30T04:23:42Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:84187" ; oboInOwl:hasExactSynonym "sheath cell of carotid body" ; a owl:Class ; rdfs:label "type II cell of carotid body" ; rdfs:subClassOf obo:CL_0000703, obo:CL_0002256 . obo:CL_0002082 obo:IAO_0000115 "A chromaffin cell of the adrenal medulla that produces epinephrine." ; terms:contributor ; oboInOwl:creation_date "2010-07-14T09:41:42Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:69322" ; oboInOwl:hasExactSynonym "adrenal secreting cell of the adrenal medulla", "adrenergic chromaffin cell", "epiniphrine secreting cell of the adrenal medulla" ; a owl:Class ; rdfs:label "type II cell of adrenal medulla" ; rdfs:subClassOf obo:CL_0000336, obo:CL_0000454 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000336 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048242 ] ) ] . obo:CL_0002083 obo:IAO_0000115 "A chromaffin cell of the adrenal medulla that produces norepinephrine." ; terms:contributor ; oboInOwl:creation_date "2010-07-14T10:12:24Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:69321" ; oboInOwl:hasExactSynonym "noradrenergic chromaffin cell" ; a owl:Class ; rdfs:label "type I cell of adrenal medulla" ; rdfs:subClassOf obo:CL_0000336, obo:CL_0000459 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000336 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048243 ] ) ] . obo:CL_0002084 obo:IAO_0000115 "A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport." ; terms:contributor ; oboInOwl:creation_date "2010-07-14T03:22:02Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Boettcher's cell", "Bottcher cell", "Bottcher's cell" ; a owl:Class ; rdfs:label "Boettcher cell" ; rdfs:subClassOf obo:CL_0002315 . obo:CL_0002085 obo:IAO_0000115 "A specialized elongated ventricular ependymal cell with one or more processes that extend into the brain parenchyma or associated blood vessels where they contact blood vessel endothelial cells and/or neurons. These cells are found in the ventricles and circumventricular organs of the brain. They are involved in hormonal regulation, gatekeeping molecules between the bloodstream and cerebrospinal fluid, metabolic sensing, and regulating food intake." ; terms:contributor ; oboInOwl:creation_date "2010-07-15T11:21:11Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0001953", "FMA:54560" ; oboInOwl:hasExactSynonym "stretch cell" ; oboInOwl:hasNarrowSynonym "tanycyte-like cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "This class includes cells that are sometimes referred to as tanycyte-like cells, located in circumventricular organs (Langlet et al., 2023) as well as tanycytes located in the ventricles." ; rdfs:label "tanycyte" ; rdfs:subClassOf obo:CL_0000065 . obo:CL_0002086 obo:IAO_0000115 "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." ; terms:contributor ; oboInOwl:creation_date "2010-07-21T01:33:38Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:67968" ; a owl:Class ; rdfs:label "specialized cardiac myocyte" ; rdfs:subClassOf obo:CL_0000746 . obo:CL_0002087 obo:IAO_0000115 "A leukocyte that lacks granules." ; terms:contributor ; oboInOwl:creation_date "2010-07-22T11:30:33Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62855" ; oboInOwl:hasExactSynonym "agranular leukocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:label "nongranular leukocyte" ; rdfs:subClassOf obo:CL_0000738, [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0030141 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000738 [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0030141 ] ) ] . obo:CL_0002088 obo:IAO_0000115 "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-07-22T03:26:00Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0003914", "FMA:86573" ; oboInOwl:hasExactSynonym "ICC", "intestinal pacemaker cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Some argue this cell type is of mesenchymal origin." ; rdfs:label "interstitial cell of Cajal" ; rdfs:subClassOf obo:CL_0000710, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043134 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000710 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043134 ] ) ] . obo:CL_0002089 obo:IAO_0000115 "A group 2 innate lymphoid cell in the mouse capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive." ; terms:contributor ; oboInOwl:creation_date "2010-08-12T02:22:19Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "nuocyte" ; a owl:Class ; rdfs:label "group 2 innate lymphoid cell, mouse" ; rdfs:subClassOf obo:CL_0001069, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001008 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001326 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001893 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001927 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000007431 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001860 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000008982 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000008994 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002830 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032616 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001069 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001008 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001326 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001893 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001927 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000007431 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001860 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000008982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000008994 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002830 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032616 ] ) ] . obo:CL_0002090 obo:IAO_0000115 "One of two small cells formed by the first and second meiotic division of oocytes." ; terms:contributor ; oboInOwl:creation_date "2010-08-23T09:49:53Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EHDAA2:0004716", "FMA:85543", "MESH:D059705", "WBbt:0008429", "XAO:0000262" ; a owl:Class ; rdfs:label "polar body" ; rdfs:subClassOf obo:CL_0000021 . obo:CL_0002091 obo:IAO_0000115 "A small cell formed by the first meiotic division of oocytes." ; terms:contributor ; oboInOwl:creation_date "2010-08-23T09:49:58Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EHDAA2:0000541", "EMAPA:16032", "FMA:18650", "VHOG:0000464" ; oboInOwl:hasExactSynonym "first polar body", "polocytus primarius" ; a owl:Class ; rdfs:label "primary polar body" ; rdfs:subClassOf obo:CL_0002090 . obo:CL_0002092 obo:IAO_0000115 "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." ; terms:contributor ; oboInOwl:creation_date "2010-07-22T04:48:15Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004850", "FMA:83621", "MESH:D001854" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense." ; rdfs:label "bone marrow cell" ; rdfs:subClassOf obo:CL_0001035, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001035 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] ) ] . obo:CL_0002093 obo:IAO_0000115 "A small cell formed by the second meiotic division of oocytes. In mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell." ; terms:contributor ; oboInOwl:creation_date "2010-08-23T09:50:01Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EHDAA2:0001820", "EMAPA:16034", "EMAPA:16045", "FMA:18651" ; oboInOwl:hasExactSynonym "polocytus secundarius", "second polar body" ; a owl:Class ; rdfs:label "secondary polar body" ; rdfs:subClassOf obo:CL_0002090 . obo:CL_0002094 obo:IAO_0000115 "A cell that makes up the loose connective tissue of the ovary." ; terms:contributor ; oboInOwl:creation_date "2010-08-23T11:11:34Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:18709" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "interstitial cell of ovary" ; rdfs:subClassOf obo:CL_0002132 . obo:CL_0002095 obo:IAO_0000115 "A cell in the hilum of the ovary that produces androgens." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-08-23T11:18:18Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:18710" ; oboInOwl:hasExactSynonym "hilar cell of ovary" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "hilus cell of ovary" ; rdfs:subClassOf obo:CL_0000593, obo:CL_0002132 . obo:CL_0002096 obo:IAO_0000115 "A specialised myocyte that lies between the sinoatrial node and the atrioventricular node and is involved in the conduction of electrical signals." ; terms:contributor ; oboInOwl:creation_date "2010-08-23T11:24:11Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:223275" ; a owl:Class ; rdfs:label "internodal tract myocyte" ; rdfs:subClassOf obo:CL_0002086, obo:CL_0008009, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009966 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009966 ] ) ] . obo:CL_0002097 obo:IAO_0000115 "A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol." ; terms:contributor ; oboInOwl:creation_date "2010-08-24T01:37:44Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:69545" ; oboInOwl:hasExactSynonym "adrenal cortex cell", "adrenocortical cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cortical cell of adrenal gland" ; rdfs:subClassOf obo:CL_0000174, obo:CL_0002078, obo:CL_1001601 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002078 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001235 ] ) ] . obo:CL_0002098 obo:IAO_0000115 "A cardiac myocyte that is connected to other cardiac myocytes by transverse intercalated discs (GO:0014704) at a regular interval." ; terms:contributor ; terms:description """Cardiac myocytes, also known as cardiac muscle cells, form the majority of the cardiac tissue and are responsible for the contractile function of the heart. These myocytes are columnar-shaped cells with centrally located nuclei, and they exhibit visibly striated cytoplasm due to the organized array of myofibrils, which are composed of filaments of actin and myosin. Cardiac myocytes connect with each other through specialized structures called intercalated discs, facilitating electrical and mechanical continuity and enabling synchronous contraction of the heart. They also possess a high number of mitochondria to meet their high energy demand for continuous heartbeat action. Cardiac myocytes are capable of automaticity, meaning they have the unique ability to spontaneously and rhythmically generate their electrical impulses, a characteristic led by pacemaker cells. The electrical signals initiated and propagated in these cells are responsible for heartbeats. They also respond to the electrical signals transmitted by the autonomic nervous system and chemical signals like hormones. Thus, cardiac myocytes not only participate in maintaining the heart’s function but also play a role in modulating heart rate and strength of contraction in response to the body's changing needs. Consequently, malfunction of these cells leads to serious cardiac diseases such as heart failure and arrhythmias. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-08-23T11:33:10Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:67967" ; oboInOwl:hasExactSynonym "regular cardiac muscle cell", "regular cardiac muscle fiber" ; a owl:Class ; rdfs:label "regular cardiac myocyte" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002098" ; rdfs:subClassOf obo:CL_0000746 . obo:CL_0002099 obo:IAO_0000115 "A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids." ; terms:contributor ; oboInOwl:creation_date "2010-08-24T01:42:02Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:69273" ; oboInOwl:hasExactSynonym "epithelial cell of zona glomerulosa of adrenal gland" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type I cell of adrenal cortex" ; rdfs:subClassOf obo:CL_0000456, obo:CL_0002097, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002053 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002097 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002053 ] ) ] . obo:CL_0002100 obo:IAO_0000115 "A regular cardiac myocyte of the interventricular region of the heart." ; terms:contributor ; oboInOwl:creation_date "2010-08-23T11:40:52Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:228792" ; a owl:Class ; rdfs:label "regular interventricular cardiac myocyte" ; rdfs:subClassOf obo:CL_0002098 . obo:CL_0002101 obo:IAO_0000115 "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." ; oboInOwl:hasExactSynonym "CD38+ naive B cell", "CD38+ naive B lymphocyte", "CD38+ naive B-cell", "CD38+ naive B-lymphocyte", "CD38-positive naive B lymphocyte", "CD38-positive naive B-cell", "CD38-positive naive B-lymphocyte" ; a owl:Class ; rdfs:label "CD38-positive naive B cell" ; rdfs:subClassOf obo:CL_0000788, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000788 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002102 obo:IAO_0000115 "A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." ; oboInOwl:hasExactSynonym "CD38- naive B cell", "CD38- naive B lymphocyte", "CD38- naive B-cell", "CD38- naive B-lymphocyte", "CD38-negative naive B lymphocyte", "CD38-negative naive B-cell", "CD38-negative naive B-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "CD38-negative naive B cell" ; rdfs:subClassOf obo:CL_0000788, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000788 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002103 obo:IAO_0000115 "An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative." ; oboInOwl:hasExactSynonym "IgG+ dn memory B cell", "IgG+ dn memory B lymphocyte", "IgG+ dn memory B-cell", "IgG+ dn memory B-lymphocyte", "IgG+ double negative memory B cell", "IgG+ double negative memory B lymphocyte", "IgG+ double negative memory B-cell", "IgG+ double negative memory B-lymphocyte", "IgG-positive dn memory B cell", "IgG-positive dn memory B lymphocyte", "IgG-positive dn memory B-cell", "IgG-positive dn memory B-lymphocyte", "IgG-positive double negative memory B lymphocyte", "IgG-positive double negative memory B-cell", "IgG-positive double negative memory B-lymphocyte" ; a owl:Class ; rdfs:label "IgG-positive double negative memory B cell" ; rdfs:subClassOf obo:CL_0000981, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071735 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000981 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071735 ] ) ] . obo:CL_0002104 obo:IAO_0000115 "An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative." ; oboInOwl:hasExactSynonym "IgG- dn memory B cell", "IgG- dn memory B lymphocyte", "IgG- dn memory B-cell", "IgG- dn memory B-lymphocyte", "IgG- double negative memory B cell", "IgG- double negative memory B lymphocyte", "IgG- double negative memory B-cell", "IgG- double negative memory B-lymphocyte", "IgG-negative dn memory B cell", "IgG-negative dn memory B lymphocyte", "IgG-negative dn memory B-cell", "IgG-negative dn memory B-lymphocyte", "IgG-negative double negative memory B lymphocyte", "IgG-negative double negative memory B-cell", "IgG-negative double negative memory B-lymphocyte" ; a owl:Class ; rdfs:label "IgG-negative double negative memory B cell" ; rdfs:subClassOf obo:CL_0000981, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071735 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000981 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071735 ] ) ] . obo:CL_0002105 obo:IAO_0000115 "A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive." ; oboInOwl:hasExactSynonym "CD38+ IgG memory B cell", "CD38+ IgG memory B lymphocyte", "CD38+ IgG memory B-cell", "CD38+ IgG memory B-lymphocyte", "CD38-positive IgG memory B lymphocyte", "CD38-positive IgG memory B-cell", "CD38-positive IgG memory B-lymphocyte" ; a owl:Class ; rdfs:label "CD38-positive IgG memory B cell" ; rdfs:subClassOf obo:CL_0000979, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000979 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002106 obo:IAO_0000115 "An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive." ; a owl:Class ; rdfs:label "IgD-positive CD38-positive IgG memory B cell" ; rdfs:subClassOf obo:CL_0002105, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002105 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] ) ] . obo:CL_0002107 obo:IAO_0000115 "An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive." ; a owl:Class ; rdfs:label "IgD-negative CD38-positive IgG memory B cell" ; rdfs:subClassOf obo:CL_0001053, obo:CL_0002105 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002105 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] ) ] . obo:CL_0002108 obo:IAO_0000115 "A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive." ; a owl:Class ; rdfs:label "CD38-negative IgG memory B cell" ; rdfs:subClassOf obo:CL_0000979, obo:CL_0001053, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000979 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002109 obo:IAO_0000115 "A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." ; oboInOwl:hasExactSynonym "B220+CD38+ naive B cell", "B220+CD38+ naive B lymphocyte", "B220+CD38+ naive B-cell", "B220+CD38+ naive B-lymphocyte", "B220-positive CD38-positive naive B lymphocyte", "B220-positive CD38-positive naive B-cell", "B220-positive CD38-positive naive B-lymphocyte", "CD38+B220+ naive B cell", "CD38+B220+ naive B lymphocyte", "CD38+B220+ naive B-cell", "CD38+B220+ naive B-lymphocyte" ; a owl:Class ; rdfs:label "B220-positive CD38-positive naive B cell" ; rdfs:subClassOf obo:CL_0002101, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002101 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] ) ] . obo:CL_0002110 obo:IAO_0000115 "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." ; a owl:Class ; rdfs:label "B220-low CD38-positive naive B cell" ; rdfs:subClassOf obo:CL_0002109, [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002101 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001014 ] ) ] . obo:CL_0002111 obo:IAO_0000115 "An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative." ; oboInOwl:hasExactSynonym "CD38- unswitched memory B cell", "CD38- unswitched memory B lymphocyte", "CD38- unswitched memory B-cell", "CD38- unswitched memory B-lymphocyte", "CD38-negative unswitched memory B lymphocyte", "CD38-negative unswitched memory B-cell", "CD38-negative unswitched memory B-lymphocyte" ; a owl:Class ; rdfs:label "CD38-negative unswitched memory B cell" ; rdfs:subClassOf obo:CL_0000970, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000970 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002112 obo:IAO_0000115 "A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." ; a owl:Class ; rdfs:label "B220-positive CD38-negative unswitched memory B cell" ; rdfs:subClassOf obo:CL_0002111, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002111 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] ) ] . obo:CL_0002113 obo:IAO_0000115 "A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." ; a owl:Class ; rdfs:label "B220-low CD38-negative unswitched memory B cell" ; rdfs:subClassOf obo:CL_0002112, [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002111 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001014 ] ) ] . obo:CL_0002114 obo:IAO_0000115 "A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative." ; oboInOwl:hasExactSynonym "CD38+ unswitched memory B cell", "CD38+ unswitched memory B lymphocyte", "CD38+ unswitched memory B-cell", "CD38+ unswitched memory B-lymphocyte", "CD38-positive unswitched memory B lymphocyte", "CD38-positive unswitched memory B-cell", "CD38-positive unswitched memory B-lymphocyte" ; a owl:Class ; rdfs:label "CD38-positive unswitched memory B cell" ; rdfs:subClassOf obo:CL_0000970, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000970 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002115 obo:IAO_0000115 "A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." ; a owl:Class ; rdfs:label "B220-positive CD38-positive unswitched memory B cell" ; rdfs:subClassOf obo:CL_0002114, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002114 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] ) ] . obo:CL_0002116 obo:IAO_0000115 "A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." ; a owl:Class ; rdfs:label "B220-low CD38-positive unswitched memory B cell" ; rdfs:subClassOf obo:CL_0002115, [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002114 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001014 ] ) ] . obo:CL_0002117 obo:IAO_0000115 "A class switched memory B cell that lacks IgG on the cell surface." ; oboInOwl:hasExactSynonym "IgG- class switched memory B cell", "IgG- class switched memory B lymphocyte", "IgG- class switched memory B-cell", "IgG- class switched memory B-lymphocyte", "IgG-negative class switched memory B lymphocyte", "IgG-negative class switched memory B-cell", "IgG-negative class switched memory B-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "IgG-negative class switched memory B cell" ; rdfs:subClassOf obo:CL_0000972, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071735 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000972 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071735 ] ) ] . obo:CL_0002118 obo:IAO_0000115 "A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative." ; a owl:Class ; rdfs:label "CD38-negative IgG-negative class switched memory B cell" ; rdfs:subClassOf obo:CL_0002117, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002117 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002119 obo:IAO_0000115 "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative." ; a owl:Class ; rdfs:label "CD38-positive IgG-negative class switched memory B cell" ; rdfs:subClassOf obo:CL_0002117, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002117 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002120 obo:IAO_0000115 "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative." ; a owl:Class ; rdfs:label "CD24-positive CD38-negative IgG-negative class switched memory B cell" ; rdfs:subClassOf obo:CL_0002118, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002118 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0002121 obo:IAO_0000115 "A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative." ; a owl:Class ; rdfs:label "CD24-negative CD38-negative IgG-negative class switched memory B cell" ; rdfs:subClassOf obo:CL_0002118, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002118 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0002122 obo:IAO_0000115 "A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative." ; a owl:Class ; rdfs:label "B220-positive CD38-positive IgG-negative class switched memory B cell" ; rdfs:subClassOf obo:CL_0002119, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002119 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] ) ] . obo:CL_0002123 obo:IAO_0000115 "A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive." ; a owl:Class ; rdfs:label "B220-low CD38-positive IgG-negative class switched memory B cell" ; rdfs:subClassOf obo:CL_0002122, [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002119 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001014 ] ) ] . obo:CL_0002124 obo:IAO_0000115 "A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma." ; terms:contributor ; oboInOwl:creation_date "2010-08-18T09:57:19Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "gammadelta27-positive", "gd27-positive" ; a owl:Class ; rdfs:label "CD27-positive gamma-delta T cell" ; rdfs:subClassOf obo:CL_0000800, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001963 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002126 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000800 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001963 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ) ] . obo:CL_0002125 obo:IAO_0000115 "A circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative and is capable of IL-17 secretion." ; terms:contributor ; oboInOwl:creation_date "2010-08-18T09:57:29Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "gammadelta-17 cells" ; a owl:Class ; rdfs:label "CD27-negative gamma-delta T cell" ; rdfs:subClassOf obo:CL_0000800, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003455 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001963 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002126 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032620 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000800 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003455 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001963 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032620 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ) ] . obo:CL_0002126 obo:IAO_0000115 "A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low)." ; terms:contributor ; oboInOwl:creation_date "2010-08-18T10:35:37Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "CD25-positive, CD27-positive immature gamma-delta T cell" ; rdfs:subClassOf obo:CL_0000799, obo:CL_0000893, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001919 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001307 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001318 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001083 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001839 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000799 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001919 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001839 ] ) ] . obo:CL_0002127 obo:IAO_0000115 "A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation." ; terms:contributor ; oboInOwl:creation_date "2010-08-20T02:14:25Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "innate effector T cell" ; rdfs:subClassOf obo:CL_0000911, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045087 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045087 ] ) ] . obo:CL_0002128 obo:IAO_0000115 "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-positive, CCR5-high, CD45RA-negative, and capable of producing IL-17 and some IFNg." ; oboInOwl:hasExactSynonym "CD8-positive Th17 cell", "Tc17 CD8+ T cell", "Tc17 T cell", "Tc17 T lymphocyte", "Tc17 T-cell", "Tc17 T-lymphocyte", "Th17 CD8-positive T cell", "Th17 non-TFH CD8-positive T cell" ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'Tc17 CD8+ T cell', but its logical definition includes additional known characteristics of Tc17 T cells. Found in the CD27-positive, CD28-positive or CD27-negative, CD28-positive fractions with the phenotype CCR4-negative and CCR7-negative (this sentence not part of definition)." ; rdfs:label "Tc17 cell" ; rdfs:subClassOf obo:CL_0000908, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001202 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032620 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001201 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000908 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001202 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032620 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001201 ] ) ] . obo:CL_0002129 obo:IAO_0000115 "Regular cardiac myocyte of a cardiac atrium." ; terms:contributor ; terms:description """Regular atrial cardiac myocytes, also known as atrial myocytes, are specialized muscle cells found in the atria – the upper chambers of the heart. They contract and relax during the heart's cycle, modulating the pumping of blood through the atria and into the ventricles. Additionally, endowed with inherent rhythmic electrical activity, atrial myocytes contribute significantly to the initiation and propagation of the heart’s electrical impulses. A distinguishing feature that separates atrial myocytes from other cardiac myocytes is their ability to synthesize and secrete atrial natriuretic peptide (ANP) in response to atrial stretch or dilatation. ANP acts as a potent vasodilator and diuretic, helping to maintain blood pressure and volume homeostasis. The phenomena of atrial stretch or distension, which triggers ANP release, is often in response to excess blood volume entering the heart, providing a mechanism at the cellular level which actively regulates systemic cardiovascular balance. Like all cardiac myocytes, atrial myocytes are embedded in a dense network of connective tissue that provides structural support. These cells are characterized by a single, centrally located nucleus, and overall, have a rod-like appearance with branching ends that connect with adjacent cells to form a continuous, synchronized ensemble. Their cytoplasm is abundant with mitochondria, reflecting the high energy demand associated with constant contraction and relaxation. At the ultrastructural level, atrial myocytes display striations due to the regular arrangement of actin and myosin proteins, which facilitate the contraction process essential for the heart's pump function. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-08-23T11:41:03Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:83108" ; oboInOwl:hasExactSynonym "atrial cardiac muscle cell", "atrial myocyte", "regular atrial cardiac muscle fiber", "regular cardiac muscle cell of atrium" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "regular atrial cardiac myocyte" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002129" ; rdfs:subClassOf obo:CL_0002098 . obo:CL_0002130 obo:IAO_0000115 "A cardiac myocyte of the interatrial region of the heart." ; terms:contributor ; oboInOwl:creation_date "2010-08-23T11:41:09Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:228790" ; a owl:Class ; rdfs:label "regular interatrial cardiac myocyte" ; rdfs:subClassOf obo:CL_0002098 . obo:CL_0002131 obo:IAO_0000115 "Regular cardiac myocyte of a cardiac ventricle." ; terms:contributor ; oboInOwl:creation_date "2010-08-23T11:41:13Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "ventricular cardiac muscle cell" ; oboInOwl:hasDbXref "FMA:83109" ; oboInOwl:hasExactSynonym "regular cardiac muscle cell of ventricle", "regular ventricular cardiac muscle fiber", "ventricular myocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "regular ventricular cardiac myocyte" ; rdfs:subClassOf obo:CL_0002098 . obo:CL_0002132 obo:IAO_0000115 "A stomal cell of the ovary" ; terms:contributor ; oboInOwl:creation_date "2010-08-23T12:10:31Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:72299" ; oboInOwl:hasExactSynonym "ovarian stromal cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "stromal cell of ovary" ; rdfs:subClassOf obo:CL_0000499, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] . obo:CL_0002133 obo:IAO_0000115 "A stromal cell of the ovarian cortex." ; terms:contributor ; oboInOwl:creation_date "2010-08-23T12:12:15Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:256169" ; a owl:Class ; rdfs:label "stromal cell of ovarian cortex" ; rdfs:subClassOf obo:CL_0002132 . obo:CL_0002134 obo:IAO_0000115 "A stromal cell of the ovarian medulla." ; terms:contributor ; oboInOwl:creation_date "2010-08-23T12:12:17Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:256171" ; a owl:Class ; rdfs:label "stromal cell of ovarian medulla" ; rdfs:subClassOf obo:CL_0002132, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013192 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013192 ] ) ] . obo:CL_0002135 obo:IAO_0000115 "Epidermal cells that do not contain keratin. Cell type is usually associated with moist epidermal tissues." ; terms:contributor ; oboInOwl:creation_date "2010-08-24T08:43:27Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62880" ; a owl:Class ; rdfs:label "nonkeratinized cell of epidermis" ; rdfs:subClassOf obo:CL_0000362, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] . obo:CL_0002136 obo:IAO_0000115 "A cell in the zona fasciculata that produce glucocorticoids, e.g cortisol." ; terms:contributor ; oboInOwl:creation_date "2010-08-24T01:50:42Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:69547" ; oboInOwl:hasExactSynonym "type II cortical cell of adrenal gland" ; a owl:Class ; rdfs:label "type II cell of adrenal cortex" ; rdfs:subClassOf obo:CL_0000460, obo:CL_0002097 . obo:CL_0002137 obo:IAO_0000115 "A cell in the zona reticularis that produce sex hormones." ; terms:contributor ; oboInOwl:creation_date "2010-08-24T01:50:44Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:69564" ; a owl:Class ; rdfs:label "type III cell of adrenal cortex" ; rdfs:subClassOf obo:CL_0000593, obo:CL_0002097 . obo:CL_0002138 obo:IAO_0000115 "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Endothelial cells of lymphatic vessels are specialized type of cells that form the interior lining of the lymphatic system, which primarily comprises the lymph vessels and nodes. These cells play a critical role in creating a barrier between the lymphatic system and the surrounding tissues. They are structurally different from the endothelial cells of the blood vessels due to the presence of anchoring filaments and lack of a continuous basement membrane, and have a unique phenotype marked by the expression of various cell-specific markers such as Prox-1, VEGFR-3, and LYVE-1. A significant function of these endothelial cells is to maintain the fluid balance within the body. They facilitate the uptake of excess interstitial fluid that collects in the body tissues, and ensure its transport back into the bloodstream via the lymphatic vessels. These cells also enable the absorption of fats and fat-soluble vitamins from the digestive system, and their subsequent transport in the form of chyle, a milky fluid, to the blood. Furthermore, endothelial cells of lymphatic vessels play a pivotal role in the body's immune response. They enable the passage of lymphocytes, that are crucial for the body's defense mechanism, from the tissues into the lymph where these cells are activated to fight against foreign bodies and infections. Also, they regulate inflammation reactions by controlling the migration of inflammatory cells, and are thus involved in pathological conditions with an inflammatory component. Lastly, these cells have been noted for their involvement in various disease states related to tissue edema, metastasis, and tumor growth, thus highlighting their importance in both health and disease states. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-08-24T02:05:28Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004167", "FMA:68458" ; oboInOwl:hasExactSynonym "LEC", "lymphatic endothelial cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "endothelial cell of lymphatic vessel" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002138" ; rdfs:subClassOf obo:CL_0002139, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001473 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0005022 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001473 ] ) ] . obo:CL_0002139 obo:IAO_0000115 "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." ; terms:contributor ; terms:description """Endothelial cells of the vascular tree, commonly referred to as vascular endothelial cells, line the entire circulatory system, from the heart to the smallest capillaries. These cells have a unique, flattened shape, and are tightly bound together, forming a thin layer known as the endothelium. The endothelium is responsible for maintaining the interior surface of blood vessels, and plays a critical role in ensuring the smooth flow of blood. Vascular endothelial cells act as a semi-permeable membrane, controlling the passage of materials and the transit of white blood cells into and out of the bloodstream. These cells are also involved in blood coagulation. When a blood vessel is damaged, endothelial cells promote clotting to prevent excessive bleeding and facilitate wound healing. Other functions include regulation of blood pressure and blood volume by releasing vasodilators and vasoconstrictors to either widen or constrict blood vessels, accordingly. Furthermore, the endothelial cells are crucial in the formation of new blood vessels, a process known as angiogenesis. This is particularly important in wound healing and the growth of new tissues during development or after injury. In the context of diseases such as cancer, angiogenesis helps facilitate tumor growth by providing nutrients and oxygen. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-08-24T02:06:40Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0001854", "CALOHA:TS-1106", "FMA:67755" ; oboInOwl:hasExactSynonym "vascular endothelial cell" ; oboInOwl:hasNarrowSynonym "cubodial endothelial cell of vascular tree" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive." ; rdfs:label "endothelial cell of vascular tree" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002139" ; rdfs:subClassOf obo:CL_0000115 ; skos:prefLabel "endothelial cell of vascular tree" . obo:CL_0002140 obo:IAO_0000115 "An acinar cell that is part of a skin sebaceous gland. This cell produces and secretes sebum into hair follicles." ; terms:contributor ; oboInOwl:creation_date "2010-08-24T09:27:52Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "acinar cell of sebaceous gland" ; oboInOwl:hasDbXref "BTO:0004613", "FMA:70953" ; oboInOwl:hasExactSynonym "acinar cell of skin sebaceous gland" ; a owl:Class ; rdfs:label "skin sebocyte" ; rdfs:subClassOf obo:CL_0000317, obo:CL_0000622, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003487 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000622 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003487 ] ) ] . obo:CL_0002141 obo:IAO_0000115 "A parathyroid chief cell that is actively secreting hormone. Have large Golgi complexes with numerous vesicles and small membrane-bound granules; secretory granules are rare, cytoplasmic glycogen sparse, much of the cytoplasm being occupied by flat sacs of granular endoplasmic reticulum in parallel arrays; in normal humans, inactive chief cells outnumber active chief cells in a ratio of 3-5:1" ; terms:contributor ; oboInOwl:creation_date "2010-08-24T09:30:15Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:69082" ; a owl:Class ; rdfs:label "active chief cell of parathyroid gland" ; rdfs:subClassOf obo:CL_0000446 . obo:CL_0002142 obo:IAO_0000115 "A cell pyramidal in shape, with their broad ends facing and forming the greater extent of the lining of the main lumen. Secretes glycoproteins associated with mucus." ; terms:contributor ; oboInOwl:creation_date "2010-08-24T02:15:16Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70659" ; a owl:Class ; rdfs:label "dark cell of eccrine sweat gland" ; rdfs:subClassOf obo:CL_0000152, obo:CL_0000318, obo:CL_0000434, obo:CL_1000448, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000423 ] . obo:CL_0002143 obo:IAO_0000115 "A chief cell that is smaller than light chief cells and has a smaller and darker nucleus and a finely granular cytoplasm with many granules." ; terms:contributor ; oboInOwl:creation_date "2010-08-24T02:18:36Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:69080" ; a owl:Class ; rdfs:label "dark chief cell of parathyroid gland" ; rdfs:subClassOf obo:CL_0000446 . obo:CL_0002144 obo:IAO_0000115 "An endothelial cell found in capillaries." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-08-24T10:15:00Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004956", "CALOHA:TS-0112", "FMA:67756" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "capillary endothelial cell" ; rdfs:subClassOf obo:CL_0002653, obo:CL_2000008, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001915 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000071 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001915 ] ) ] . obo:CL_0002145 obo:IAO_0000115 "A multi-ciliated epithelial cell located in the trachea and bronchi, characterized by a columnar shape and motile cilia on its apical surface. These cilia facilitate mucociliary clearance by moving mucus and trapped particles toward the pharynx." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Ciliated columnar cells of the tracheobronchial tree compose the inner lining of the tracheobronchial tree, the system of airways consisting of trachea, bronchi and bronchioles that allow passage of air into the lungs, where gas exchange occurs. A defining feature of these endo-epithelial cells are the tiny hair-like structures covering their surface, known as cilia. The nucleus is located at the base of the cell, and the area above it is rich in mitochondria and well-developed endoplasmic reticulum, both crucial for the energy-intensive process of cilia operation. The primary function of these ciliated cells is to keep the respiratory tract clean via mucociliary clearance or the respiratory escalator. These cells create a two-layered 'coat': The lower \"sol\" layer is watery where the cilia can beat in coordinated waves, and the upper \"gel\" layer is thick and sticky, trapping inhaled particles, such as dust, bacteria, viruses, and other potentially harmful substances. This rhythmical beating of the cilia then moves the mucus and trapped particles upwards and out of the respiratory tract, which is then either coughed out or swallowed. Damage or dysfunction of these ciliated cells, as seen in diseases such as primary ciliary dyskinesia, cystic fibrosis, or chronic bronchitis, may lead to reduced or ineffective mucociliary clearance and an increased susceptibility to respiratory infections. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-08-24T03:38:29Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70542" ; oboInOwl:hasExactSynonym "ciliated columnar cell of tracheobronchial tree" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The marker set C1orf194, MS4A8 can identify the Human cell type multiciliated columnar cell of tracheobronchial tree in the lung with a confidence of 0.86 (NS-Forest FBeta value).", "These cells possess numerous cilia on their surface, typically ranging from 200 to 300 per cell. The cilia vary in length, measuring between 6 to 7 μm in the upper airways (trachea) and becoming shorter, around 4 μm, in the smaller airways (terminal bronchioles). These cells form a two-layered 'coat' in the airway: the lower 'sol' layer is watery, allowing the cilia to beat in coordinated waves, while the upper 'gel' layer is thick and sticky, trapping inhaled particles." ; rdfs:label "multiciliated columnar cell of tracheobronchial tree" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002145" ; rdfs:subClassOf obo:CL_0002202, obo:CL_4030034, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002209 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000041 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008397 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0031514 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0010007 ] ) ] . obo:CL_0002146 obo:IAO_0000115 "A sweat producing cell of eccrine sweat glands. Pyramidal in shape, with its base resting on the basal lamina or myoepitheliocytes, and its microvillus-covered apical plasma membrane line up the intercellular canaliculi. Cell is not stained by hematoxylin or eosin." ; terms:contributor ; oboInOwl:creation_date "2010-08-24T10:33:02Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70658" ; a owl:Class ; rdfs:label "clear cell of eccrine sweat gland" ; rdfs:subClassOf obo:CL_0000152, obo:CL_0000318, obo:CL_0000434, obo:CL_1000448, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000423 ] . obo:CL_0002147 obo:IAO_0000115 "A chief cell of parathyroid glands that does not stain with hematoxylin or eosin. This cell is larger, has a larger nucleus and fewer secretory granules than dark chief cells." ; terms:contributor ; oboInOwl:creation_date "2010-08-24T10:39:42Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:69081" ; oboInOwl:hasExactSynonym "clear chief cell of parathyroid cell" ; a owl:Class ; rdfs:label "clear chief cell of parathyroid gland" ; rdfs:subClassOf obo:CL_0000446 . obo:CL_0002148 obo:IAO_0000115 "A cell found within the dental pulp." ; terms:contributor ; oboInOwl:creation_date "2010-08-24T02:52:09Z"^^xsd:dateTime ; oboInOwl:hasDbXref "CALOHA:TS-0195", "FMA:87170" ; a owl:Class ; rdfs:label "dental pulp cell" ; rdfs:subClassOf obo:CL_0002159, obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001754 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002159 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001754 ] ) ] . obo:CL_0002149 obo:IAO_0000115 "An epithelial cell of the uterus. This cell has a mesodermal origin." ; terms:contributor ; oboInOwl:creation_date "2010-08-24T10:45:54Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:256161" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "epithelial cell of uterus" ; rdfs:subClassOf obo:CL_0002078, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006955 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006955 ] ) ] . obo:CL_0002150 obo:IAO_0000115 "Epithelioid macrophage is an activated macrophage that resembles an epithelial cell with finely granular, pale eosinophilic cytoplasm and central, ovoid nucleus (oval or elongate). This cell type is able to merge into one another to form aggregates. The presence of such aggregates may characterize some pathologic conditions, mainly granulomatous inflammation." ; terms:contributor ; oboInOwl:creation_date "2010-08-24T03:48:30Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "epithelioid cell" ; oboInOwl:hasDbXref "FMA:83514" ; oboInOwl:hasExactSynonym "epithelioid histocyte", "epitheloid macrophage" ; a owl:Class ; rdfs:label "epithelioid macrophage" ; rdfs:subClassOf obo:CL_0000235, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000861 ] . obo:CL_0002151 obo:IAO_0000115 "A promyelocyte that is considerably smaller, with more condensed chromatin, and nucleoli are no longer conspicuous." ; terms:contributor ; oboInOwl:creation_date "2010-08-24T03:07:50Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:83534" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "late promyelocyte" ; rdfs:subClassOf obo:CL_0000836 . obo:CL_0002152 obo:IAO_0000115 "A simple columnar epithelial cell located in the endocervix." ; terms:contributor ; oboInOwl:creation_date "2010-08-24T10:47:47Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:86486" ; a owl:Class ; rdfs:label "columnar cell of endocervix" ; rdfs:subClassOf obo:CL_0000146, obo:CL_0002535, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012252 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000146 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012252 ] ) ] . obo:CL_0002153 obo:IAO_0000115 "The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-08-24T10:53:03Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0001943", "FMA:68650" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "corneocyte" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000225, obo:CL_0000255, obo:CL_0000311, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002027 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000312 ] . obo:CL_0002154 obo:IAO_0000115 "A promyelocyte with a nucleus that is indented and contains more marginated heterochromatin compared to its precursor cell (myeloblast); cytoplasm is deeply basophilic and contains numerous mitochondria and meandering cysternae of endoplasmic reticulum; largest of the granulocyte lineages." ; terms:contributor ; oboInOwl:creation_date "2010-08-24T03:07:53Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:83533" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "early promyelocyte" ; rdfs:subClassOf obo:CL_0000836 . obo:CL_0002155 obo:IAO_0000115 "A crenated erythrocyte with 30+ crenations, bumps or spurs that are the result of damage due to age or disease." ; terms:contributor ; oboInOwl:creation_date "2010-08-24T03:15:21Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:81099" ; oboInOwl:hasExactSynonym "burr cell" ; a owl:Class ; rdfs:label "echinocyte" ; rdfs:subClassOf obo:CL_0000595 . obo:CL_0002156 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000764 ; a owl:Class ; owl:deprecated true . obo:CL_0002157 obo:IAO_0000115 "A cell type that makes up the highly vascular membrane lining the marrow cavity of long bones." ; terms:contributor ; terms:description """Endosteal cells, also known as osteogenic cells, are a specialized type of cell that resides in the endosteum of the bone marrow cavity. The endosteum is a thin vascular membrane of connective tissue that lines the inner surface of the bony tissue that forms the medullary cavity of long bones. This specific location assigns endosteal cells critical roles in the bone maintenance and regeneration process as they actively participate in bone remodeling, a process that involves both the formation and resorption of bone tissue. Endosteal cells function by regulating the activity of both osteoblasts and osteoclasts. Osteoblasts are cells that deposit new bone, and osteoclasts are responsible for bone resorption, a process important for the maintenance, repair, and remodelling of bones. When new bone tissue is required, such as in instances of bone fractures or increased mechanical stress, endosteal cells differentiate into osteoblasts to facilitate the bone formation process. Conversely, when bone resorption is necessary, these cells are known to release signals that lead to the recruitment and activation of osteoclasts. In addition to this, endosteal cells play a significant role in hematopoiesis, which is the formation of blood cellular components. They function in this process by providing a niche for hematopoietic stem cells, serving to support their maintenance and differentiation. Understanding the functionality of endosteal cells is important in the field of regenerative medicine and stem cell therapy, especially in diseases affecting bone remodeling and hematopoiesis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-08-24T03:33:58Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:86495" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "endosteal cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002157" ; rdfs:subClassOf obo:CL_0001035, obo:CL_0002078, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009859 ] . obo:CL_0002158 obo:IAO_0000115 "Epithelial cell found on the external side of the tympanic membrane" ; terms:contributor ; oboInOwl:creation_date "2010-08-25T10:25:31Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70558" ; a owl:Class ; rdfs:label "external epithelial cell of tympanic membrane" ; rdfs:subClassOf obo:CL_0002159 . obo:CL_0002159 obo:IAO_0000115 "Epithelial cells derived from general body ectoderm and ectoderm placodes." ; terms:contributor ; oboInOwl:creation_date "2010-08-26T08:31:08Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70556" ; a owl:Class ; rdfs:label "general ecto-epithelial cell" ; rdfs:subClassOf obo:CL_0002077 . obo:CL_0002160 obo:IAO_0000115 "A cell type found in the basal epithelial layer on the external side of the tympanic membrane. Cell type is flattened with intracellular spaces of variable dimensions." ; terms:contributor ; oboInOwl:creation_date "2010-08-25T10:28:44Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "basal external epithelial cell of tympanic membrane" ; rdfs:subClassOf obo:CL_0002158 . obo:CL_0002161 obo:IAO_0000115 "A cell type found on the superficial layer of the external side of the tympanic membrane. This cell-type lacks a nucleus." ; terms:contributor ; oboInOwl:creation_date "2010-08-25T10:28:48Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "superficial external epithelial cell of tympanic membrane" ; rdfs:subClassOf obo:CL_0002158 . obo:CL_0002162 obo:IAO_0000115 "An extremely flattened cell type found on the inner side of the tympanic membrane. The surface of this cell type carries sparse pleomorphic microvilli that are more common near the junctional zones." ; terms:contributor ; oboInOwl:creation_date "2010-08-25T10:49:46Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70626" ; a owl:Class ; rdfs:label "internal epithelial cell of tympanic membrane" ; rdfs:subClassOf obo:CL_0002076, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002364 ] . obo:CL_0002163 obo:IAO_0000115 "A rod-shpaed cell that forms a single row adjacent to and supporting the inner hair cells." ; terms:contributor ; oboInOwl:creation_date "2010-08-25T11:05:21Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:75726" ; a owl:Class ; rdfs:label "internal pillar cell of cochlea" ; rdfs:subClassOf obo:CL_1000191 . obo:CL_0002164 obo:IAO_0000115 "A rod-shaped cell found in 3 or 4 rows that lie adjacent to and support the outer hair cells." ; terms:contributor ; oboInOwl:creation_date "2010-08-25T11:05:23Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:75727" ; a owl:Class ; rdfs:label "external pillar cell of cochlea" ; rdfs:subClassOf obo:CL_1000191 . obo:CL_0002165 obo:IAO_0000115 "A supporting cell that is attached to the basement membrane and forms rows that support the hair cells." ; terms:contributor ; oboInOwl:creation_date "2010-08-25T01:29:07Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:79800" ; a owl:Class ; rdfs:label "phalangeal cell" ; rdfs:subClassOf obo:CL_0002490 . obo:CL_0002166 obo:IAO_0000115 "An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth." ; terms:contributor ; oboInOwl:creation_date "2010-08-26T08:51:27Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62987" ; oboInOwl:hasExactSynonym "epithelial cell rests of Malassez", "epithelial debris of Malassez" ; a owl:Class ; rdfs:label "epithelial cell of Malassez" ; rdfs:subClassOf obo:CL_0002159, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011595 ] . obo:CL_0002167 obo:IAO_0000115 "A specialized cell involved in sensory perception of smell." ; terms:contributor ; oboInOwl:creation_date "2010-08-26T01:47:13Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:67870" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "olfactory epithelial cell" ; rdfs:subClassOf obo:CL_0000098, obo:CL_0000206, obo:CL_0000710, obo:CL_0002319, obo:CL_0002631, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001997 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050911 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001997 ] ) ] ; skos:prefLabel "olfactory epithelial cell" . obo:CL_0002168 obo:IAO_0000115 "A border cell is a slender columnar cell on the medial portion of the basilar membrane." ; terms:contributor ; oboInOwl:creation_date "2010-08-25T01:47:12Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:79798" ; a owl:Class ; rdfs:label "border cell of cochlea" ; rdfs:subClassOf obo:CL_0002315 . obo:CL_0002169 obo:IAO_0000115 "An epithelial cell located on the basal lamina of the olfactory epithelium." ; terms:contributor ; oboInOwl:creation_date "2010-08-26T01:58:54Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "horizontal basal cell" ; oboInOwl:hasDbXref "FMA:62303" ; a owl:Class ; rdfs:label "basal cell of olfactory epithelium" ; rdfs:subClassOf obo:CL_0002167, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000482 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002167 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000482 ] ) ] ; skos:prefLabel "basal cell of olfactory epithelium" . obo:CL_0002170 obo:IAO_0000115 "A keratinized cell located in the hard palate or gingiva." ; terms:contributor ; oboInOwl:creation_date "2010-08-26T02:51:30Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "keratinized cell of the oral mucosa" ; rdfs:subClassOf obo:CL_0000237, obo:CL_0002336, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003729 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000237 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003729 ] ) ] . obo:CL_0002171 obo:IAO_0000115 "A rounded or elliptical epithelial cell, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles; form a distinct basal zone spaced slightly from the basal surface of the epithelium." ; terms:contributor ; oboInOwl:creation_date "2010-08-26T01:59:18Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:67874" ; oboInOwl:hasExactSynonym "blastema cell of olfactory epithelium" ; a owl:Class ; rdfs:label "globose cell of olfactory epithelium" ; rdfs:subClassOf obo:CL_0002169 . obo:CL_0002172 obo:IAO_0000115 "A long, spindle-shaped supporting cells arranged in parallel rows that secretes components of the tectorial membrane and potassium ions into the endolymph." ; terms:contributor ; oboInOwl:creation_date "2010-08-25T02:02:48Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:79797" ; oboInOwl:hasExactSynonym "interdental cell" ; a owl:Class ; rdfs:label "interdental cell of cochlea" ; rdfs:subClassOf obo:CL_0002315, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002276 ] . obo:CL_0002173 obo:IAO_0000115 "A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells." ; terms:contributor ; oboInOwl:creation_date "2010-08-25T02:20:55Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:84143", "KUPO:0001033" ; oboInOwl:hasExactSynonym "Goormaghtigh cell", "polar cushion cells" ; oboInOwl:hasRelatedSynonym "lacis cell" ; a owl:Class ; rdfs:label "extraglomerular mesangial cell" ; rdfs:subClassOf obo:CL_0000650, obo:CL_1000618, obo:CL_1001318, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002321 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002320 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002321 ] ) ] . obo:CL_0002174 obo:IAO_0000115 "A cell within the follicle of an ovary." ; obo:RO_0002161 obo:NCBITaxon_50557 ; terms:contributor ; oboInOwl:creation_date "2010-08-25T03:01:27Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EMAPA:31247", "FMA:70589" ; a owl:Class ; rdfs:label "follicular cell of ovary" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001305 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001305 ] ) ] . obo:CL_0002175 obo:IAO_0000115 "A cell within the primary follicle of the ovary." ; terms:contributor ; oboInOwl:creation_date "2010-08-25T03:03:42Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70590" ; a owl:Class ; rdfs:label "primary follicular cell of ovary" ; rdfs:subClassOf obo:CL_0002174 . obo:CL_0002176 obo:IAO_0000115 "A cell of a secondary follicile within the ovary." ; terms:contributor ; oboInOwl:creation_date "2010-08-25T03:03:48Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70591" ; a owl:Class ; rdfs:label "secondary follicular cell of ovary" ; rdfs:subClassOf obo:CL_0002174 . obo:CL_0002177 obo:IAO_0000115 "A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature." ; terms:contributor ; oboInOwl:creation_date "2010-08-25T03:10:10Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:83102" ; oboInOwl:hasExactSynonym "folliculostellate cell of pars anterior of adenohypophysis" ; a owl:Class ; rdfs:label "folliculostellate cell of pars distalis of adenohypophysis" ; rdfs:subClassOf obo:CL_0000642, obo:CL_0000710, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006964 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000642 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006964 ] ) ] . obo:CL_0002178 obo:IAO_0000115 "An epithelial cell found in the lining of the stomach." ; terms:contributor ; oboInOwl:creation_date "2010-08-25T03:22:08Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62948" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "epithelial cell of stomach" ; rdfs:subClassOf obo:CL_0002251, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001276 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001276 ] ) ] . obo:CL_0002179 obo:IAO_0000115 "A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall." ; terms:contributor ; oboInOwl:creation_date "2010-08-25T03:23:22Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62949", "FMA:86552" ; oboInOwl:hasExactSynonym "surface mucosal cell of stomach" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "foveolar cell of stomach" ; rdfs:subClassOf obo:CL_0000075, obo:CL_0002180 . obo:CL_0002180 obo:IAO_0000115 "An epithelial cell of the stomach. This cell produces mucous." ; terms:contributor ; oboInOwl:creation_date "2010-08-25T03:38:51Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:63464" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "mucous cell of stomach" ; rdfs:subClassOf obo:CL_0000319, obo:CL_0002178, obo:CL_1100001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001276 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070254 ] ) ] . obo:CL_0002181 obo:IAO_0000115 "A columnar epithelial mucous secreting cell located in the neck of the gastric glands. These cells have numerous apical secretory vesicles containing mucins and a basally displaced nucleus. The mucous they secrete is distinct histochemically from that of the surface mucous cells of stomach." ; terms:contributor , ; terms:date "2025-02-21T11:14:30Z"^^xsd:dateTime ; oboInOwl:creation_date "2010-08-25T03:41:30Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "neck cell" ; oboInOwl:hasDbXref "FMA:62954" ; oboInOwl:hasExactSynonym "mucous neck cell" ; a owl:Class ; rdfs:label "mucous neck cell of gastric gland" ; rdfs:subClassOf obo:CL_0000075, obo:CL_0000152, obo:CL_0002180, obo:CL_0002659, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000325 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0098594 ] . obo:CL_0002182 obo:IAO_0000115 "OBSOLETE. A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall." ; obo:IAO_0100001 obo:CL_0002179 ; terms:contributor ; oboInOwl:creation_date "2010-08-25T03:45:10Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62949" ; a owl:Class ; rdfs:comment "Duplicate with foveolar cell of stomach" ; rdfs:label "obsolete surface mucosal cell of stomach" ; owl:deprecated true . obo:CL_0002183 obo:IAO_0000115 "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit." ; terms:contributor ; oboInOwl:creation_date "2010-08-25T03:57:08Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62953" ; a owl:Class ; rdfs:label "stem cell of gastric gland" ; rdfs:subClassOf obo:CL_0000048, obo:CL_0002178, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000325 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000048 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000325 ] ) ] . obo:CL_0002184 obo:IAO_0000115 "A flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells; lie in contact with the basal lamina of olfactory epithelium." ; terms:contributor ; oboInOwl:creation_date "2010-08-26T01:59:22Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62304" ; oboInOwl:hasExactSynonym "horizontal basal cells" ; a owl:Class ; rdfs:label "basal proper cell of olfactory epithelium" ; rdfs:subClassOf obo:CL_0002169 . obo:CL_0002185 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000312 ; a owl:Class ; owl:deprecated true . obo:CL_0002186 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000649 ; a owl:Class ; owl:deprecated true . obo:CL_0002187 obo:IAO_0000115 "A mitotically active, columnar-shaped keratinocyte located in the stratum basale of the epidermis and attached to the basement membrane. This cell exhibits heterogeneity, encompassing stem and progenitor subpopulations with distinct molecular and proliferative characteristics (Haensel et al., 2020), and serves as the primary source of new keratinocytes for epidermal renewal, homeostasis, and regeneration." ; terms:contributor ; oboInOwl:creation_date "2010-08-26T03:12:49Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70571" ; oboInOwl:hasExactSynonym "epidermal basal cell", "epidermal basal keratinocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "basal cell of epidermis" ; rdfs:subClassOf obo:CL_0000646, obo:CL_0011026, obo:CL_1000428, obo:CL_4052061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002025 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030216 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000646 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002025 ] ) ] . obo:CL_0002188 obo:IAO_0000115 "An endothelial cell that is part of the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate." ; terms:contributor ; oboInOwl:creation_date "2010-08-26T10:59:44Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004632", "FMA:70970" ; oboInOwl:inSubset cl:cellxgene_subset, cl:kidney_upper_slim ; a owl:Class ; rdfs:comment "Glomerular endothelial cells have 60-80 nm fenestrations typically lacking diaphragms in adults but present during embryonic development. Some studies found diaphragms in 2-6% of mature rat glomerular capillaries. Their presence may depend on fixation techniques, developmental stage, or dynamic cell changes. Additionally, these cells help maintain the structural integrity of glomerular capillaries through interactions with the basement membrane and podocytes." ; rdfs:label "glomerular endothelial cell" ; rdfs:subClassOf obo:CL_0000666, obo:CL_0002681, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000074 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0036053 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000074 ] ) ] . obo:CL_0002189 obo:IAO_0000115 "A keratinocyte located in the stratum granulosum of the epidermis, characterized by the presence of keratohyalin granules containing filaggrin—which aggregate keratin filament —and by lamellar granules that secrete lipids and enzymes essential for forming the skin’s waterproof barrier. As these cells progress toward the surface, they adopt a flattened morphology and initiate keratinization to become corneocyte and form the protective stratum corneum. In human epidermis, granular keratinocytes are transcriptomically distinguished by high expression of differentiation markers such as DSC1, KRT2, IVL, and TGM3 (Wang et al., 2020), and LOR, FLG, and SPINK5 (Cheng et al., 2018)." ; terms:contributor ; oboInOwl:creation_date "2010-08-26T03:19:00Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70543" ; oboInOwl:hasExactSynonym "granular keratinocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "granular cell of epidermis" ; rdfs:subClassOf obo:CL_0000712, obo:CL_4052061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0036457 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0097209 ] . obo:CL_0002190 obo:IAO_0000115 "A flat keratinocyte immediately below the cornified layer." ; terms:contributor ; oboInOwl:creation_date "2010-08-26T03:37:02Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:86925" ; a owl:Class ; rdfs:label "squamous cell of epidermis" ; rdfs:subClassOf obo:CL_0000312 . obo:CL_0002191 obo:IAO_0000115 "A cell involved in the formation of a granulocyte." ; terms:contributor ; oboInOwl:creation_date "2010-08-30T12:54:27Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:83519" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "granulocytopoietic cell" ; rdfs:subClassOf obo:CL_0000839, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030851 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000839 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030851 ] ) ] . obo:CL_0002192 obo:IAO_0000115 "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare." ; terms:contributor ; oboInOwl:creation_date "2010-08-30T01:08:15Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:83541" ; a owl:Class ; rdfs:label "metamyelocyte" ; rdfs:subClassOf obo:CL_0000763, obo:CL_0002191, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002193 ] . obo:CL_0002193 obo:IAO_0000115 "A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-08-30T01:08:19Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0000734", "FMA:83525" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "myelocyte" ; rdfs:subClassOf obo:CL_0000763, obo:CL_0002191, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000836 ] . obo:CL_0002194 obo:IAO_0000115 "A cell involved in the formation of a monocyte (monopoiesis)." ; terms:contributor ; oboInOwl:creation_date "2010-08-30T01:27:48Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:83552" ; a owl:Class ; rdfs:label "monopoietic cell" ; rdfs:subClassOf obo:CL_0000839, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030224 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000839 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030224 ] ) ] . obo:CL_0002195 obo:IAO_0000115 "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)." ; terms:contributor ; oboInOwl:creation_date "2010-08-30T02:00:42Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:86577" ; oboInOwl:hasRelatedSynonym "HpSC" ; a owl:Class ; rdfs:label "hepatic stem cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/800" ; rdfs:subClassOf obo:CL_0000048, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000048 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:CL_0002196 obo:IAO_0000115 "A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratio that can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue." ; obo:RO_0002175 obo:NCBITaxon_9606 ; obo:RO_0004050 "Liver progenitor cells have been variously named in rodent and human studies as oval cells, hepatic progenitor cells, liver stem cells, ductular reactions, or atypical ductular cells. They were first described as oval cells in rats due to their large nuclear-to-cytoplasm ratio and oval-shaped nuclei. On the difference between 'hepatic liver stem cells' (HLSC) and 'oval cells': \"... unlike a well-known hepatic progenitor cell population, known as oval cells in rodents, HLSCs do not express CK-7, CK-19, c-kit, CD133 and alpha-smooth muscle actin (α-SMA) (Gaudio et al., 2009)\"." ; terms:contributor ; oboInOwl:creation_date "2010-08-30T02:01:49Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004270", "FMA:86576" ; oboInOwl:hasExactSynonym "hepatic oval cell", "hepatic progenitor cell", "liver progenitor cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "hepatic oval stem cell" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" . obo:CL_0002197 obo:IAO_0000115 "A parathyroid chief cell that is not actively secreting hormone. Contains small Golgi complexes with only a few grouped vesicles and membrane-bound secretory granules; glycogen and many lipofuscin granules abound but sacs of granular endoplasmic reticulum are rare and dispersed. In normal humans, inactive chief cells out number active chief cells in a ratio of 3-5:1." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T11:14:01Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "inactive chief cell of parathyoid gland" ; rdfs:subClassOf obo:CL_0000446 . obo:CL_0002198 obo:IAO_0000115 "A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T11:26:49Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:67606", "MESH:D024862" ; oboInOwl:hasExactSynonym "oxyphil" ; a owl:Class ; rdfs:label "oncocyte" ; rdfs:subClassOf obo:CL_0002076 . obo:CL_0002199 obo:IAO_0000115 "An oncocyte located in the parathyroid gland." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T11:33:23Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:69084" ; a owl:Class ; rdfs:label "oxyphil cell of parathyroid gland" ; rdfs:subClassOf obo:CL_0002198, obo:CL_0002260 . obo:CL_0002200 obo:IAO_0000115 "An oncocyte located in the thyroid." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T11:33:26Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:87169" ; oboInOwl:hasExactSynonym "Askanazy cells", "Hurthle cells" ; a owl:Class ; rdfs:label "oxyphil cell of thyroid" ; rdfs:subClassOf obo:CL_0002198, obo:CL_0002257 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002198 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002046 ] ) ] . obo:CL_0002201 obo:IAO_0000115 "A renal intercalated cell that secretes base and reabsorbs acid in the distal segments of the kidney tubule to maintain acid/base balance." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-09-02T01:43:55Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "type B intercalated cell", "type B-IC" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "renal beta-intercalated cell" ; rdfs:subClassOf obo:CL_0005010 . obo:CL_0002202 obo:IAO_0000115 "An epithelial cell of the tracheobronchial tree." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T02:09:14Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:66816" ; a owl:Class ; rdfs:label "epithelial cell of tracheobronchial tree" ; rdfs:subClassOf obo:CL_0002632, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008397 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008397 ] ) ] . obo:CL_0002203 obo:IAO_0000115 "A tuft cell that is part of the epithelium of large intestine." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T02:20:50Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:263222" ; oboInOwl:hasExactSynonym "brush cell of epithelium proper of large intestine", "brush cell of large intestine", "tuft cell of epithelium of large intestine" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Brush cells are a distinct cell type from brush border cell-types." ; rdfs:label "tuft cell of large intestine" ; rdfs:subClassOf obo:CL_0002253, obo:CL_0019032 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001278 ] ) ] . obo:CL_0002204 obo:IAO_0000115 "An epithelial cell found in various organs, including the gastrointestinal and respiratory tracts, characterized by a tuft of 120-140 blunt microvilli on its apical surface. This cell exhibits diverse functions depending on its location, which includes chemosensation, initiation of immune responses, contribution to mucociliary clearance, and defense against parasites." ; terms:contributor ; terms:description """Brush cells, also referred to as tuft cells or multivesicular cells, are a specialized type of epithelial cell mainly noted for their characteristic 'brush border' composed of microvilli. These cells reside in the epithelial lining of tissue organs such as the respiratory tract, gastrointestinal tract, and the bile ducts. The name derives from their distinct appearance under the microscope, which resembles a brush due to the dense layer of microvilli protruding into the lumen. A key function of brush cells is chemosensation: They express a variety of signaling molecules and receptors that enable them to detect specific chemical stimuli in the environment and act as sensory transducers. Many of these receptors are responsive to luminal content, which makes brush cells vital for regulating and coordinating appropriate physiological responses to changes in these substances. Recent research has also elucidated an important role for these cells in immunity. Intestinal brush cells have been found to be the source of a cytokine called interleukin-25, which can initiate type 2 immune responses during parasitic infections. This immune function, along with the chemosensing abilities, signifies that brush cells could serve crucial roles in health and disease, although much research is still required to fully elucidate their myriad roles in physiology and pathology. Overall, brush cells are a versatile cell type, whose distinct morphology and functional capabilities allow them to perform a unique set of functions within the body. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-09-02T02:28:53Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:67978" ; oboInOwl:hasExactSynonym "brush cell", "caveolated cell", "fibrillovesicular cell", "multivesicular cell", "peculiar cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "tuft cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002204" ; rdfs:subClassOf obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0151001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0151001 ] ) ] . obo:CL_0002205 obo:IAO_0000115 "A brush cell found in the epithelium of lobular bronchiole." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T02:38:34Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:263220" ; a owl:Class ; rdfs:label "brush cell of lobular bronchiole" ; rdfs:subClassOf obo:CL_0000082, obo:CL_0002075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8600001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8600001 ] ) ] . obo:CL_0002206 obo:IAO_0000115 "A brush cell of the epithelium in the terminal bronchiole." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T02:38:36Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:263228" ; a owl:Class ; rdfs:label "brush cell of terminal bronchiole" ; rdfs:subClassOf obo:CL_0000082, obo:CL_0002075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001958 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001958 ] ) ] . obo:CL_0002207 obo:IAO_0000115 "Brush cell of the epithelium in the trachea." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-09-02T02:38:37Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:263224" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "brush cell of trachea" ; rdfs:subClassOf obo:CL_0000307, obo:CL_0002075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001901 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001901 ] ) ] . obo:CL_0002208 obo:IAO_0000115 "A brush cell found in the epithelium of bronchus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-09-02T02:38:42Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:263226" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "brush cell of bronchus" ; rdfs:subClassOf obo:CL_0002075, obo:CL_0002328 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002031 ] ) ] . obo:CL_0002209 obo:IAO_0000115 "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T02:53:59Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:69060" ; oboInOwl:hasExactSynonym "undifferentiated columnar cell of tracheobronchial tree" ; a owl:Class ; rdfs:label "intermediate epitheliocyte" ; rdfs:subClassOf obo:CL_0002202 . obo:CL_0002210 obo:IAO_0000115 "A slow muscle cell that contains high levels of myoglobin and oxygen storing proteins giving the cell a red appearance." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T03:20:03Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:84448" ; oboInOwl:hasExactSynonym "oxidative muscle fiber", "red muscle fiber" ; a owl:Class ; rdfs:label "red muscle cell" ; rdfs:subClassOf obo:CL_0008046 . obo:CL_0002211 obo:IAO_0000115 "A slow muscle cell that has large amounts of myoglobin, stores energy as triglycerides, generates ATP by the oxidative method and is resistant to fatigue." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T03:24:05Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0001812", "CALOHA:TS-0940", "FMA:84413" ; oboInOwl:hasExactSynonym "slow twitch fiber", "slow twitch muscle cell", "slow twitch muscle fiber", "slow-twitch muscle fiber", "type 1 muscle cell", "type 1 muscle fiber", "type I muscle fiber" ; oboInOwl:hasRelatedSynonym "intermediate muscle fiber" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type I muscle cell" ; rdfs:subClassOf obo:CL_0000189, obo:CL_0002210 . obo:CL_0002212 obo:IAO_0000115 "A fast muscle fiber cell that stores energy in the form of glycogen and creatine phosphate." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T03:28:45Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0001813", "FMA:84414" ; oboInOwl:hasExactSynonym "type 2 muscle cell", "type 2 muscle fiber", "type II muscle fiber" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type II muscle cell" ; rdfs:subClassOf obo:CL_0000190 . obo:CL_0002213 obo:IAO_0000115 "A muscle cell with low content of myoglobin and other oxygen storing proteins. This muscle cell has a white appearance." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T03:28:48Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:84449" ; a owl:Class ; rdfs:label "white muscle cell" ; rdfs:subClassOf obo:CL_0000190 . obo:CL_0002214 obo:IAO_0000115 "A type II muscle cell that contains large amounts of myoglobin, has many mitochondria and very many blood capillaries. Type II A cells are red, have a very high capacity for generating ATP by oxidative metabolic processes, split ATP at a very rapid rate, have a fast contraction velocity and are resistant to fatigue." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T03:31:38Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0001813", "FMA:84415" ; oboInOwl:hasExactSynonym "fast twitch A", "fatigue resistant fast twitch muscle cell", "type 2a muscle cell", "type 2a muscle fiber", "type IIa muscle fiber" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type IIa muscle cell" ; rdfs:subClassOf obo:CL_0002210, obo:CL_0002212 . obo:CL_0002215 obo:IAO_0000115 "A type II muscle cell that contains a low content of myoglobin, relatively few mitochondria, relatively few blood capillaries and large amounts of glycogen. Type II B fibres are white, geared to generate ATP by anaerobic metabolic processes, not able to supply skeletal muscle fibres continuously with sufficient ATP, fatigue easily, split ATP at a fast rate and have a fast contraction velocity." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T03:31:42Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:84416" ; oboInOwl:hasExactSynonym "type 2b muscle cell", "type 2b muscle fiber", "type IIb muscle fiber" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type IIb muscle cell" ; rdfs:subClassOf obo:CL_0002212, obo:CL_0002213 . obo:CL_0002216 obo:IAO_0000115 "An intermediate muscle cell that has characteristics of both fast and slow muscle cells." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T03:51:17Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:84450" ; a owl:Class ; rdfs:label "intermediate muscle cell" ; rdfs:subClassOf obo:CL_0008046 . obo:CL_0002217 obo:IAO_0000115 "A trophoblast that leaves the placenta and invades the endometrium and myometrium. This cell type is crucial in increasing blood flow to the fetus." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T04:04:36Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0002366", "FMA:86564" ; a owl:Class ; rdfs:label "intermediate trophoblast cell" ; rdfs:subClassOf obo:CL_0000351 . obo:CL_0002218 obo:IAO_0000115 "A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." ; terms:contributor ; oboInOwl:creation_date "2010-10-07T01:58:00Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "immature DEC precursor", "immature DETC precursor" ; a owl:Class ; rdfs:comment "NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments." ; rdfs:label "immature dendritic epithelial T cell precursor" ; rdfs:subClassOf obo:CL_0002404 . obo:CL_0002219 obo:IAO_0000115 "A trophoblast found at the junction of the placenta. This cell type makes a unique fibronectin-trophouteronectin junction that helps mediate attachment of the placenta to the uterus. This cell type is also found junction of the chorion layer of the external membranes and the decidua." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T04:14:28Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "anchoring trophoblast" ; rdfs:subClassOf obo:CL_0000351 . obo:CL_0002220 obo:IAO_0000115 "A cell located between the pinealocytes." ; terms:contributor ; oboInOwl:creation_date "2010-09-02T04:28:41Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:86575" ; a owl:Class ; rdfs:label "interstitial cell of pineal gland" ; rdfs:subClassOf obo:CL_0000710 ; skos:prefLabel "interstitial cell of pineal gland" . obo:CL_0002221 obo:IAO_0000115 "A squamous cell that has keratin in the esophagus." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T10:11:06Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:86549" ; a owl:Class ; rdfs:label "keratinized squamous cell of esophagus" ; rdfs:subClassOf obo:CL_0000237, obo:CL_0002252 . obo:CL_0002222 obo:IAO_0000115 "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T10:38:03Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70950" ; oboInOwl:inSubset cl:eye_upper_slim ; a owl:Class ; rdfs:label "vertebrate lens cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0000306, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000965 ] . obo:CL_0002223 obo:IAO_0000115 "A cell of the transparent layer of simple cuboidal epithelium over the anterior surface of the lens; transform into lens fiber(s)." ; terms:contributor ; terms:description """The anterior lens cells, also known as lens epithelial cells, are an integral part of the eye's structure and play a critical role in the organ's physiological functioning. They are situated in the anterior portion of the lens, precisely in the lens capsule, and stretch over the lens' frontal surface. The primary function of anterior lens cells is to facilitate eye accommodation by controlling the shape and thickness of the eye lens. The cells are involved in continuous proliferation, migration, and differentiation into lens fiber cells, helping to maintain lens growth and transparency. Anterior lens cells have a prolonged life span and reveal an extraordinary ability to function indefinitely, a characteristic that is critical for maintaining lens transparency. Damage or disturbance to the anterior lens cells can give rise to lens opacity, eventually leading to cataracts, which is a common cause of vision loss. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-09-07T10:45:45Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:63181" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "anterior lens cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002223" ; rdfs:subClassOf obo:CL_0002224 . obo:CL_0002224 obo:IAO_0000115 "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-09-07T10:45:47Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:67559" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "lens epithelial cell" ; rdfs:subClassOf obo:CL_0000075, obo:CL_0002222, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001803 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001803 ] ) ] . obo:CL_0002225 obo:IAO_0000115 "A lens fiber cell that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Secondary lens fibers are a specialized type of elongated cells located within the structure of the eye's lens. They play an essential role in vision by enabling light transmission and focus on the retina, which allows for clear, distinct vision. These cells are characterized by their lack of nuclei and organelles, their orderly alignment, and their high protein content, particularly crystallins. Lens fibers are differentiated from equatorial epithelial cells of the lens in a process that involves cell elongation, denucleation and tight packing, which serve to reduce light scattering occurrences in the eye. This differentiation accelerates substantially after birth in comparison to during embryogenesis and continues throughout life, contributing to the growth of the eye lens. Secondary lens fibers are specifically those cells that are newly differentiated and cover the old lens fiber core. This process also leads to the removal of light-obstructing cellular components, mainly nuclei and organelles, making these fibers transparent and ideal for their function. The fibers carry out their primary function of light refraction via a high concentration of specialized proteins known as crystallins, which form a gradient of refractive index together with the cytoplasm. This index manipulation facilitates precise light focus onto the retina. Secondary lens fibers also contribute to the lens's shape and biomechanical properties through intercellular interactions, particularly at the sutures where the ends of the fibers meet. Any disruption to secondary lens fibers can lead to vision problems, including cataracts, which is the clouding of the lens resulting from the aggregation of crystallin proteins. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-09-07T10:53:39Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "secondary lens fibre" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "secondary lens fiber" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002225" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0011004, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002228 ] . obo:CL_0002226 obo:IAO_0000115 "A secondary lens fiber cell that lacks a nucleus." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T11:15:23Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:67561" ; oboInOwl:hasExactSynonym "non-nucleated secondary lens fibre" ; a owl:Class ; rdfs:label "non-nucleated secondary lens fiber" ; rdfs:subClassOf obo:CL_0002225, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002227 ] . obo:CL_0002227 obo:IAO_0000115 "A secondary fiber cell that contains a nucleus." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T11:15:26Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70949" ; oboInOwl:hasExactSynonym "nucleated secondary lens fibre" ; a owl:Class ; rdfs:label "nucleated secondary lens fiber" ; rdfs:subClassOf obo:CL_0002225 . obo:CL_0002228 obo:IAO_0000115 "An elongating cell that rapidly obliterates the lumen of the lens vesicle. Subsequently, differentiation of this cell type at the lens equator leads to the formation of secondary fiber cells that come to overlie the primary fibers." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-09-07T11:19:01Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70613" ; oboInOwl:hasExactSynonym "primary lens fibre" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "primary lens fiber" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0011004, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002223 ] . obo:CL_0002229 obo:IAO_0000115 "A chief cell that is bigger than dark chief cells and has a larger and lighter nucleus and a cytoplasm with few granules." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T11:46:54Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:69079" ; a owl:Class ; rdfs:label "light chief cell of parathyroid gland" ; rdfs:subClassOf obo:CL_0000446 . obo:CL_0002230 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002325 ; a owl:Class ; owl:deprecated true . obo:CL_0002231 obo:IAO_0000115 "An epithelial cell of the prostate." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T01:49:29Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:256163", "FMA:66817" ; oboInOwl:hasExactSynonym "prostate epithelial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "epithelial cell of prostate" ; rdfs:subClassOf obo:CL_0002076, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:CL_0002232 obo:IAO_0000115 "An epithelial cell of prostatic duct." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T01:55:51Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:74224" ; oboInOwl:hasExactSynonym "ductal epithelial cell of prostate" ; a owl:Class ; rdfs:label "epithelial cell of prostatic duct" ; rdfs:subClassOf obo:CL_0000072, obo:CL_0002231, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000072 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002485 ] ) ] . obo:CL_0002233 obo:IAO_0000115 "An epithelial cell of the prostatic acinus." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T01:55:53Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:74223" ; oboInOwl:hasExactSynonym "acinar epithelial cell of prostate" ; a owl:Class ; rdfs:label "epithelial cell of prostatic acinus" ; rdfs:subClassOf obo:CL_0002231, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004179 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002231 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004179 ] ) ] . obo:CL_0002234 obo:IAO_0000115 "A cell of the basal layer of the epithelium in the prostatic acinus." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T01:59:08Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:74265" ; oboInOwl:hasExactSynonym "basal epithelial cell of prostatic acinus" ; a owl:Class ; rdfs:label "basal cell of prostatic acinus" ; rdfs:subClassOf obo:CL_0002233, obo:CL_0002341 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002341 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004179 ] ) ] . obo:CL_0002235 obo:IAO_0000115 "A cell of the luminal layer of the epithelium in the prostatic acinus." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T01:59:10Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:74266" ; a owl:Class ; rdfs:label "luminal cell of prostatic acinus" ; rdfs:subClassOf obo:CL_0002233, obo:CL_0002340 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002340 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004179 ] ) ] . obo:CL_0002236 obo:IAO_0000115 "A cell that constitutes the basal layer of epithelium in the prostatic duct." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T01:59:12Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:74226" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "basal epithelial cell of prostatic duct" ; rdfs:subClassOf obo:CL_0000068, obo:CL_0002341, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002341 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002485 ] ) ] . obo:CL_0002237 obo:IAO_0000115 "A cell that constitutes the luminal layer of epithelium of prostatic duct." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T01:59:16Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:74225" ; a owl:Class ; rdfs:label "luminal epithelial cell of prostatic duct" ; rdfs:subClassOf obo:CL_0000068, obo:CL_0002340, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002340 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002485 ] ) ] . obo:CL_0002238 obo:IAO_0000115 "A primordial germ cell that is destined to become a male germ cell." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T02:11:13Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EHDAA2:0001053", "EMAPA:18686", "FMA:84771", "VHOG:0000662" ; oboInOwl:hasExactSynonym "male primordial germ cell", "testis primordial germ cell" ; a owl:Class ; rdfs:label "male gonocyte" ; rdfs:subClassOf obo:CL_0000670, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000473 ] . obo:CL_0002239 obo:IAO_0000115 "A primordial cell from which an oocyte (ovum) ultimately is developed." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T02:11:16Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EHDAA2:0000505", "EMAPA:17965", "FMA:84772", "ISBN:0721662544", "VHOG:0000661" ; oboInOwl:hasExactSynonym "ovary primordial germ cell", "ovigerm" ; a owl:Class ; rdfs:label "ooblast" ; rdfs:subClassOf obo:CL_0000255, obo:CL_0000670, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] . obo:CL_0002240 obo:IAO_0000115 "A fibroblast in the bone marrow." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T02:25:18Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:84377" ; a owl:Class ; rdfs:label "marrow fibroblast" ; rdfs:subClassOf obo:CL_0000057, obo:CL_0010001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] ) ] . obo:CL_0002241 obo:IAO_0000115 "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-09-07T02:29:38Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:84467" ; oboInOwl:hasExactSynonym "pulmonary myofibroblast", "pulmonary septal cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "The marker set DPT, APOD can identify the Human cell type pulmonary interstitial fibroblast in the lung with a confidence of 0.58 (NS-Forest FBeta value)." ; rdfs:label "pulmonary interstitial fibroblast" ; rdfs:subClassOf obo:CL_0000057, obo:CL_4030031, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000046 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005169 ] ) ] . obo:CL_0002242 obo:IAO_0000115 "A cell containing at least one nucleus." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T03:32:33Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:67513" ; a owl:Class ; rdfs:label "nucleate cell" ; rdfs:subClassOf obo:CL_0000000, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002505 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002505 ] ) ] ; skos:prefLabel "nucleate cell" . obo:CL_0002243 obo:IAO_0000115 "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." ; terms:contributor ; terms:description """The smooth muscle cell of sphincter of pupil is a specialized cell type typically found within the eye, more specifically within the sphincter muscle of the iris. These cells can constrict and dilate in response to light signals, tightly regulating the amount of light reaching the retina. Contraction narrows the pupil in bright conditions (pupillary constriction), protecting the retina from excessive light. In low light, relaxation allows dilation (pupillary dilation), enhancing visual perception in dim conditions. These cells are also innervated by parasympathetic fibers from the oculomotor nerve. Light signals to the Edinger-Westphal nucleus stimulate the release of acetylcholine, contracting the cells. On the contrary, sympathetic stimulation induces relaxation. This precise control plays a crucial role in optimizing visual function, highlighting their essential role in vision biology. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-09-08T08:53:42Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70611" ; oboInOwl:hasExactSynonym "smooth muscle fiber of sphincter of pupil" ; oboInOwl:hasRelatedSynonym "smooth muscle fibre of sphincter of pupil" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "smooth muscle cell of sphincter of pupil" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002243" ; rdfs:subClassOf obo:CL_0000358, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001607 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000133 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001607 ] ) ] . obo:CL_0002244 obo:IAO_0000115 "A stratified squamous epithelial cell located in the ectocervix." ; terms:contributor ; oboInOwl:creation_date "2010-09-08T09:12:23Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:86483" ; oboInOwl:hasExactSynonym "ectocervical squamous cell" ; a owl:Class ; rdfs:label "squamous cell of ectocervix" ; rdfs:subClassOf obo:CL_1001575, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012251 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012251 ] ) ] . obo:CL_0002245 obo:IAO_0000115 "OBSOLETE: A lymphocyte that lacks T or B cell surface markers." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T03:43:42Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:83601" ; a owl:Class ; rdfs:label "obsolete null lymphocyte" ; owl:deprecated true . obo:CL_0002246 obo:IAO_0000115 "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T03:57:09Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0002669", "FMA:86711", "MESH:D000072916" ; oboInOwl:hasExactSynonym "PBSC" ; a owl:Class ; rdfs:label "peripheral blood stem cell" ; rdfs:subClassOf obo:CL_0000037, obo:CL_0000080, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] . obo:CL_0002247 obo:IAO_0000115 "A tissue macrophage that is in the pleural space." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T04:16:43Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:83024" ; a owl:Class ; rdfs:label "pleural macrophage" ; rdfs:subClassOf obo:CL_0000864 . obo:CL_0002248 obo:IAO_0000115 "A pluripotent stem cell has the ability to form cells from all three germ layers (ectoderm, mesoderm, and endoderm). However, unlike totipotent stem cells, they cell can not generate all the cells of the whole organism such as placenta." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T04:26:06Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70570", "MESH:D039904" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "pluripotent stem cell" ; rdfs:subClassOf obo:CL_0000723 . obo:CL_0002249 obo:IAO_0000115 "A stem cell that can differentiate into a cardiac myocyte." ; terms:contributor ; oboInOwl:creation_date "2010-09-07T04:40:32Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:75620" ; a owl:Class ; rdfs:label "primitive cardiac myocyte" ; rdfs:subClassOf obo:CL_0000035, obo:CL_0002078 . obo:CL_0002250 obo:IAO_0000115 "A stem cell located in epithelium the based of the crypt of Lieberkuhn. Division of these cells serve both to maintain the stem cell population and produce the transit amplifying cells that are all precursors of all cell types that populate the intestinal epithelium." ; terms:contributor ; terms:description """Intestinal crypt stem cells, also known as crypt base columnar cells, are a unique type of cell, characterized by the highly specific marker LGR5, found in the intestinal epithelium. Situated at the bottom of the minute pockets known as crypts of Lieberkühn, these are undifferentiated cells that have the ability to perpetually self-renew, as well as differentiate into various other cell types that constitute the epithelial lining of the intestine. The fundamental role of intestinal crypt stem cells is to provide a constant supply of new cells to maintain the cellular turnover of the intestinal epithelium, a tissue known for rapid self-renewal. These stem cells are nurtured and protected by specialized epithelial and mesenchymal cells, and together constitute the intestinal stem cell niche. An important function of intestinal crypt stem cells is to sustain the balance between cell division and programmed cell death, called apoptosis, to ensure the integrity of the intestinal lining. Given their active proliferation rate, these stem cells initiate the creation of diverse differentiated cell types, including enterocytes (the primary absorptive cells in the intestinal lumen), goblet cells (that produce mucus to protect the epithelial layer), enteroendocrine cells (involved in producing gastrointestinal hormones), and Paneth cells (involved in secreting antimicrobial peptides). This diversity in output regulates the physiological activities of the gut ranging from nutrient absorption, hormone secretion, bacterial balance, to immunity. Research studies suggest that dysregulation in intestinal crypt stem cell proliferation and differentiation is associated with several intestinal disorders including intestinal cancer, and various enteropathies. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-09-08T09:21:22Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:63379" ; oboInOwl:hasExactSynonym "stem cell of intestinal crypt of Lieberkuhn" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "intestinal crypt stem cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002250" ; rdfs:subClassOf obo:CL_0000048, obo:CL_0002563, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001983 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000034 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001983 ] ) ] . obo:CL_0002251 obo:IAO_0000115 "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." ; terms:contributor ; oboInOwl:creation_date "2010-09-08T09:26:53Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "epithelial cell of alimentary canal" ; rdfs:subClassOf obo:CL_0002076, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003929 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003929 ] ) ] . obo:CL_0002252 obo:IAO_0000115 "An epithelial cell of the lining of the esophagus." ; terms:contributor ; oboInOwl:creation_date "2010-09-08T09:28:20Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:63071", "ZFA:0009400" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "epithelial cell of esophagus" ; rdfs:subClassOf obo:CL_0002251, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001976 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001976 ] ) ] . obo:CL_0002253 obo:IAO_0000115 "An epithelial cell of the lining of the large intestine." ; terms:contributor ; oboInOwl:creation_date "2010-09-08T09:28:22Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004297", "FMA:256157" ; oboInOwl:hasRelatedSynonym "epithelial cell of colon" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "epithelial cell of large intestine" ; rdfs:subClassOf obo:CL_0002563, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001278 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002563 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] . obo:CL_0002254 obo:IAO_0000115 "An epithelial cell of the lining of the small intestine." ; terms:contributor ; oboInOwl:creation_date "2010-09-08T09:41:46Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:256159" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "epithelial cell of small intestine" ; rdfs:subClassOf obo:CL_0002563, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002563 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:CL_0002255 obo:IAO_0000115 "A stromal cell of the endometrium, characterized by its fibroblast-like morphology, regenerative capacity, and ability to undergo decidualization. It differentiates into a decidual stromal cell during pregnancy, essential for embryo implantation and maintenance. This cell is involved in tissue proliferation, remodeling, and breakdown, responding to hormonal changes, particularly estrogen and progesterone." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-09-08T09:50:04Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "stromal cell of uterus" ; oboInOwl:hasDbXref "CALOHA:TS-1266", "FMA:86490" ; oboInOwl:hasExactSynonym "endometrial stromal cell", "endometrial stromal fibroblast" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "stromal cell of endometrium" ; rdfs:subClassOf obo:CL_0000499, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002337 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0046697 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002388 ; owl:someValuesFrom obo:CL_2000002 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002337 ] ) ] . obo:CL_0002256 obo:IAO_0000115 "A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings." ; terms:contributor ; oboInOwl:creation_date "2010-09-08T10:34:45Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:84188" ; oboInOwl:hasExactSynonym "carotid body sustentacular cell" ; a owl:Class ; rdfs:label "supporting cell of carotid body" ; rdfs:subClassOf obo:CL_0000630, obo:CL_0000710 . obo:CL_0002257 obo:IAO_0000115 "An epithelial cell of thyroid gland." ; terms:contributor ; oboInOwl:creation_date "2010-09-08T01:46:51Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:256167", "MESH:D000072637" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "epithelial cell of thyroid gland" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0002076, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002046 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002046 ] ) ] . obo:CL_0002258 obo:IAO_0000115 "An epithelial cell that is part of the thyroid follicle epithelium, with a shape that ranges from squamous when inactive to cuboidal or columnar when active, reflecting its hormonal activity. Its apical surface is lined with microvilli projecting into the colloid-filled lumen, where it synthesizes, stores, and secretes the thyroid hormones thyroxine (T4) and triiodothyronine (T3), releasing them into the bloodstream in response to thyroid-stimulating hormone (TSH)." ; terms:contributor , ; oboInOwl:creation_date "2010-09-08T01:50:08Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0003736", "CALOHA:TS-1285", "FMA:68782" ; oboInOwl:hasExactSynonym "follicular cell of thyroid gland", "principal cell of thyroid gland", "thyroid gland follicular cell", "thyroid hormone secreting cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "thyroid follicular cell" ; rdfs:subClassOf obo:CL_0000163, obo:CL_0000167, obo:CL_0002257, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012363 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005902 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0070460 [ a owl:Restriction ; owl:onProperty obo:RO_0002339 ; owl:someValuesFrom obo:UBERON_0001009 ] ) ] ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012363 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0070460 [ a owl:Restriction ; owl:onProperty obo:RO_0002339 ; owl:someValuesFrom obo:UBERON_0001009 ] ) ] ] ) ] . obo:CL_0002259 obo:IAO_0000115 "The stem cell from which glial precursor cell arises from." ; terms:contributor ; oboInOwl:creation_date "2010-09-08T02:14:14Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:87171" ; oboInOwl:hasNarrowSynonym "totipotent neuroepithelial stem cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "neuroepithelial stem cell" ; rdfs:subClassOf obo:CL_0000723 . obo:CL_0002260 obo:IAO_0000115 "An epithelial cell of the parathyroid gland." ; terms:contributor ; oboInOwl:creation_date "2010-09-08T02:29:38Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70547" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "epithelial cell of parathyroid gland" ; rdfs:subClassOf obo:CL_0002076, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001132 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001132 ] ) ] . obo:CL_0002261 obo:IAO_0000115 "An endothelial cell found in the mucosa associated with the facial skeleton." ; terms:contributor ; oboInOwl:creation_date "2010-09-14T10:40:12Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70627" ; a owl:Class ; rdfs:label "endothelial cell of viscerocranial mucosa" ; rdfs:subClassOf obo:CL_0002076 . obo:CL_0002262 obo:IAO_0000115 "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Endothelial cells of sinusoids, often referred to as sinusoidal endothelial cells (SECs), are a specialized type of endothelial cell that primarily reside in the capillaries of the liver, spleen, and bone marrow. These cells form the innermost monolayer of the sinusoidal blood vessels, also known as sinusoids, that mediate the exchange of nutrients, metabolites, and waste materials between the blood and the surrounding organ tissue. SECs possess distinctive morphological features including a large, flattened shape, an abundance of fenestrations or pores, and the lack of a continuous basement membrane. These structural characteristics distinguish sinusoidal endothelial cells from other, more regularly structured endothelial cells in the body. Due to their special fenestrated structure, SECs facilitate the exchange of macromolecules, like lipoproteins and hyaluronan, between plasma and the surrounding organ parenchymal cells. These fenestrations act like sieves, allowing the passage of substances based on their size and charge. It's noteworthy that the permeability characteristics of SECs can be regulated dynamically according to the body's homeostatic needs. Beyond their key role in exchange mechanisms, endothelial cells of sinusoids are involved in several other functions. In the liver, for example, they help in the removal and endocytic degradation of waste macromolecules, immune response, and regulation of liver regeneration. They also participate in the formation and remodeling of blood vessels, a process known as angiogenesis. Additionally, in recent years, it has been discovered that these cells may have a role in disease conditions like cirrhosis and liver cancer. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-09-14T10:57:26Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:63134" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "endothelial cell of sinusoid" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002262" ; rdfs:subClassOf obo:CL_0000071, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003909 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003909 ] ) ] . obo:CL_0002263 obo:IAO_0000115 "One of three types of epithelial cells that populate the parathyroid gland; cytological characteristics intermediate between those of the chief cell and of the oxyphil cell. Because only one hormone is produced, the three cell forms are widely believed to be different phases in the life cycle of a single cell type, with the chief cell being its physiologically active stage." ; terms:contributor ; oboInOwl:creation_date "2010-09-08T02:33:50Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:69324" ; a owl:Class ; rdfs:label "transitional cell of parathyroid gland" ; rdfs:subClassOf obo:CL_0002260 . obo:CL_0002264 obo:IAO_0000115 "A type of enteroendocrine cell found in the stomach that secretes glucagon." ; terms:contributor ; oboInOwl:creation_date "2010-09-10T10:54:42Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:83411" ; a owl:Class ; rdfs:label "type A cell of stomach" ; rdfs:subClassOf obo:CL_0002067, obo:CL_1001517 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002067 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001276 ] ) ] . obo:CL_0002265 obo:IAO_0000115 "A D cell located in the colon." ; terms:contributor ; oboInOwl:creation_date "2010-09-10T11:37:35Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:268744" ; oboInOwl:hasExactSynonym "colon D-cell", "colonic delta cell", "delta cell of colon" ; a owl:Class ; rdfs:label "type D cell of colon" ; rdfs:subClassOf obo:CL_0000502, obo:CL_0009042, obo:CL_1001588 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000502 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:CL_0002266 obo:IAO_0000115 "A type D cell of the small intestine." ; terms:contributor ; oboInOwl:creation_date "2010-09-10T01:34:22Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:268736" ; oboInOwl:hasExactSynonym "delta cell of small intestine", "small intestine D-cell", "small intestine delta cell" ; a owl:Class ; rdfs:label "type D cell of small intestine" ; rdfs:subClassOf obo:CL_0000502, obo:CL_0009006 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000502 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:CL_0002267 obo:IAO_0000115 "A type D cell found in the stomach." ; terms:contributor ; oboInOwl:creation_date "2010-09-10T01:36:03Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:83410" ; oboInOwl:hasExactSynonym "delta cell of stomach", "stomach D-cell", "stomach delta cell" ; a owl:Class ; rdfs:label "type D cell of stomach" ; rdfs:subClassOf obo:CL_0000502, obo:CL_0002659, obo:CL_1000222 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000502 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001276 ] ) ] . obo:CL_0002268 obo:IAO_0000115 "An enteroendocrine cell that stores and secretes Ghrelin." ; terms:contributor ; oboInOwl:creation_date "2010-09-10T01:47:45Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:63418" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "P/D1 enteroendocrine cell" ; rdfs:subClassOf obo:CL_0000164, obo:CL_0002269 . obo:CL_0002269 obo:IAO_0000115 "An endocrine cell that secretes vasoactive intestinal peptide." ; terms:contributor ; oboInOwl:creation_date "2010-09-10T01:52:20Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "vasoactive intestinal peptide secreting cell" ; rdfs:subClassOf obo:CL_0000167 . obo:CL_0002270 obo:IAO_0000115 "A type EC enteroendocrine cell in the duodenum and jejunum that stores and secretes motilin and 5-hydroxytryptamine." ; terms:contributor ; oboInOwl:creation_date "2010-09-10T02:13:47Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "Mo enteroendocrine cell" ; oboInOwl:hasDbXref "FMA:62941" ; a owl:Class ; rdfs:label "type EC2 enteroendocrine cell" ; rdfs:subClassOf obo:CL_0000577, obo:CL_0002272, obo:CL_1001516 . obo:CL_0002271 obo:IAO_0000115 "A type EC enteredocrine cell in the intestines that stores and secretes substance P and 5-hydroxytryptamine." ; terms:contributor ; oboInOwl:creation_date "2010-09-10T02:13:49Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62940" ; a owl:Class ; rdfs:label "type EC1 enteroendocrine cell" ; rdfs:subClassOf obo:CL_0000505, obo:CL_0000577, obo:CL_1001516 . obo:CL_0002272 obo:IAO_0000115 "A cell that secretes motilin, a gastric hormone that at low pH inhibits gastric motor activity, whereas at high pH has a stimulating effect." ; terms:contributor ; oboInOwl:creation_date "2010-09-10T02:31:13Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "motilin secreting cell" ; rdfs:subClassOf obo:CL_0000167 . obo:CL_0002273 obo:IAO_0000115 "A type EC enteroendocrine cell type that is numerous in the fundus of the stomach; stores 5-hydroxytryptamine and histamine." ; terms:contributor ; oboInOwl:creation_date "2010-09-10T02:35:17Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:63208" ; a owl:Class ; rdfs:label "type ECL enteroendocrine cell" ; rdfs:subClassOf obo:CL_0000577, obo:CL_0002274 . obo:CL_0002274 obo:IAO_0000115 "A cell type that secretes histamine." ; terms:contributor ; oboInOwl:creation_date "2010-09-10T03:04:42Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "histamine secreting cell" ; rdfs:subClassOf obo:CL_0000457, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001821 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001821 ] ) ] . obo:CL_0002275 obo:IAO_0000115 "A PP cell located in the islets of the pancreas." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Pancreatic polypeptide (PP) cells (also called F or gamma cells) are unique endocrine cells located within the Islets of Langerhans in the pancreas. PP cells are one of the rarer pancreatic cell types and are more prevalent in the head and neck of the pancreas. They are critical in normal pancreatic physiological functions and are involved in the development of pancreatic endocrine disorders. The primary function of PP cells is the production and secretion of the pancreatic polypeptide hormone (PP). This hormone plays a crucial role in several gastrointestinal functions and metabolic responses. The release of the PP hormone is stimulated after eating, especially in protein-rich meals, leading to it being present in large amounts during digestion. The fundamental role of PP is to self-regulate pancreatic secretion activities ensuring its exocrine and endocrine functions are under control. The pancreatic polypeptide hormone from PP cells also aids in adapting to low physical activity and fasting by reducing the production of insulin and glucagon and inhibiting the hepatic glucose production. Additionally, this hormone influences gut motility by slowing down the gastric emptying and reducing small intestinal transit, thereby controlling the pace at which nutritional substances are absorbed. Because of these functions, any malfunction or irregularity in PP cells can result in various disorders such as diabetes and pancreatic diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-09-10T03:30:31Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0000805", "FMA:70588", "MESH:D050418", "ZFA:0005742" ; oboInOwl:hasExactSynonym "PP cell of pancreatic islet", "PP-cell of pancreatic islet", "pancreatic polypeptide-secreting cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell." ; rdfs:label "pancreatic PP cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002275" ; rdfs:subClassOf obo:CL_0000696, obo:CL_0008024, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000006 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000696 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000006 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-islets-langerhans/v1.2/assets/2d-ftu-pancreas-islets-langerhans.png" . obo:CL_0002276 obo:IAO_0000115 "OBSOLETE: A PP cell located in the pancreatic acinus. Obsoleted due to a lack of published evidence that this cell type is actually found in the pancreatic acinus." ; terms:contributor ; oboInOwl:creation_date "2010-09-10T03:30:33Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:85400" ; oboInOwl:hasExactSynonym "type F cell of pancreatic acinus" ; a owl:Class ; rdfs:label "obsolete PP cell of pancreatic acinus" ; owl:deprecated true . obo:CL_0002277 obo:IAO_0000115 "An enteroendocrine cell commonest in the duodenum and jejunum, rare in ileum, that secretes cholecystokinin. This cell type is involved in the regulation of digestive enzymes and bile." ; terms:contributor ; oboInOwl:creation_date "2010-09-10T03:44:36Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62937" ; oboInOwl:hasExactSynonym "CCK cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type I enteroendocrine cell" ; rdfs:subClassOf obo:CL_0000167, obo:CL_0009006 . obo:CL_0002278 obo:IAO_0000115 "An enteroendocrine cell of duodenum and jejunum that produces gastric inhibitory peptide." ; terms:contributor ; oboInOwl:creation_date "2010-09-10T03:51:47Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62942" ; oboInOwl:hasExactSynonym "type K enteroendocrine cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "GIP cell" ; rdfs:subClassOf obo:CL_0000167, obo:CL_0009006 . obo:CL_0002279 obo:IAO_0000115 "A enteroendocrine cell type that is numerous in ileum, present in jejunum and large intestine, few in duodenum. This cell type produces glucagon-like immunoreactants (glicentin, glucagon-37, glucagon-29, GLP-1 and -2) and PYY." ; terms:contributor ; oboInOwl:creation_date "2010-09-10T03:59:09Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62944" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type L enteroendocrine cell" ; rdfs:subClassOf obo:CL_0000167, obo:CL_1001516 . obo:CL_0002280 obo:IAO_0000115 "An enteroendocrine cell found in the ileum and jejunum that produces neurotensin." ; terms:contributor ; oboInOwl:creation_date "2010-09-10T04:08:29Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62943" ; oboInOwl:hasExactSynonym "N cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type N enteroendocrine cell" ; rdfs:subClassOf obo:CL_0000167, obo:CL_0009006 . obo:CL_0002281 obo:IAO_0000115 "Scattered in duodenojejunal mucosa, this enteroendocrine cell secretes secretin and serotonin." ; terms:contributor ; oboInOwl:creation_date "2010-09-10T04:44:46Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62936" ; a owl:Class ; rdfs:label "type S enteroendocrine cell" ; rdfs:subClassOf obo:CL_0000167, obo:CL_0000458, obo:CL_0009006 . obo:CL_0002282 obo:IAO_0000115 "An enteroendocrine cell which produces a gastrin- and cholecystokinin-like peptide. The apical microvilli-rich plasma membrane is in open contact with the small intestine mucosa. This cell type is devoid of gastrin-17 but contains other fragments of the gastrin polypeptide." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T09:48:34Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:63421" ; a owl:Class ; rdfs:label "type TG enteroendocrine cell" ; rdfs:subClassOf obo:CL_0000164, obo:CL_0000509 . obo:CL_0002283 obo:IAO_0000115 "An epithelial cell of the mucosa associated with facial skeleton." ; terms:contributor ; oboInOwl:creation_date "2010-09-14T11:04:02Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70581" ; a owl:Class ; rdfs:label "ecto-epithelial cell of viscerocranial mucosa" ; rdfs:subClassOf obo:CL_0002159 . obo:CL_0002284 obo:IAO_0000115 "An enteroendocrine cell found in the fundus and pylorus; this cell type has dense round secretory granules that contain ghrelin." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T10:12:12Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:63209" ; oboInOwl:hasExactSynonym "A-like", "X/A-like" ; a owl:Class ; rdfs:label "type X enteroendocrine cell" ; rdfs:subClassOf obo:CL_0000164, obo:CL_0005018 . obo:CL_0002285 obo:IAO_0000115 "A taste receptor cell that is characterized by morphologically identifiable synaptic contacts with the gustatory nerve fibers and expression of the synaptic membrane protein-25 (SNAP-25) and NCAM." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T10:57:21Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "taste bud basal cell" ; oboInOwl:hasDbXref "FMA:67940" ; oboInOwl:hasExactSynonym "type 3 taste cell" ; a owl:Class ; rdfs:label "type III taste bud cell" ; rdfs:subClassOf obo:CL_0000048, obo:CL_0000209 . obo:CL_0002286 obo:IAO_0000115 "A taste receptor cell that has a short microvilli, a projecting apical region, a large rounded nucleus, and expresses taste chemoreceptors thus making them the transducing cell for taste qualities." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T10:57:26Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62381" ; oboInOwl:hasExactSynonym "type 2 taste cell" ; a owl:Class ; rdfs:label "type II taste cell" ; rdfs:subClassOf obo:CL_0000209 . obo:CL_0002287 obo:IAO_0000115 "A rounded, mitotically active stem cell which is the source of new cells of the taste bud; located basally." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T10:57:29Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "taste bud basal cell" ; oboInOwl:hasDbXref "FMA:62380" ; oboInOwl:hasExactSynonym "type 4 taste cell" ; a owl:Class ; rdfs:comment "There is debate about the exact lineage of these cell types from this progenitor. See PMID:15738192." ; rdfs:label "type IV taste receptor cell" ; rdfs:subClassOf obo:CL_0000034, obo:CL_0000209 . obo:CL_0002288 obo:IAO_0000115 "A cell type that forms the boundary with the surrounding epithelium." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T10:57:31Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:67941" ; a owl:Class ; rdfs:label "type V taste receptor cell" ; rdfs:subClassOf obo:CL_0000209 . obo:CL_0002289 obo:IAO_0000115 "A densely staining taste receptor cell that contains many dense vacuoles in their apical regions which project into the apical space and bear microvilli. This cell type serves as a supporting cell by surrounding and isolating the other cell types from each other; secrete a dense amorphous material that surrounds the microvilli in the taste pore. This cell type expresses a glial glutumate transporter, GLAST." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T10:57:35Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62356" ; oboInOwl:hasExactSynonym "dark tongue cell", "type I taste cell", "type taste 1 cell" ; a owl:Class ; rdfs:label "type I taste bud cell" ; rdfs:subClassOf obo:CL_0000209, obo:CL_0000703 . obo:CL_0002290 obo:IAO_0000115 "A sperm bearing a Y chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T11:35:24Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:84058" ; oboInOwl:hasExactSynonym "Y bearing sperm", "Y-bearing sperm" ; a owl:Class ; rdfs:label "Y chromosome-bearing sperm cell" ; rdfs:subClassOf obo:CL_0000019 . obo:CL_0002291 obo:IAO_0000115 "A sperm bearing an X chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T11:35:26Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:84057" ; oboInOwl:hasExactSynonym "X bearing sperm", "X-bearing sperm" ; a owl:Class ; rdfs:label "X chromosome-bearing sperm cell" ; rdfs:subClassOf obo:CL_0000019 . obo:CL_0002292 obo:IAO_0000115 "A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-09-13T01:40:21Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:84186" ; oboInOwl:hasExactSynonym "glomus cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "type I cell of carotid body" ; rdfs:subClassOf obo:CL_0000710 . obo:CL_0002293 obo:IAO_0000115 "An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T02:34:22Z"^^xsd:dateTime ; oboInOwl:hasDbXref "CALOHA:TS-1040", "FMA:72208" ; oboInOwl:hasExactSynonym "epithelial cell of thymus gland", "epithelial reticular cell", "epithelial reticular cell of thymus", "thymic epithelial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "epithelial cell of thymus" ; rdfs:subClassOf obo:CL_0002076, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] ) ] . obo:CL_0002294 obo:IAO_0000115 "An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T02:37:23Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:72209" ; oboInOwl:hasRelatedSynonym "subcapsular thymic epithelial cell" ; a owl:Class ; rdfs:label "type-1 epithelial cell of thymus" ; rdfs:subClassOf obo:CL_0002364 . obo:CL_0002295 obo:IAO_0000115 "A thymic epithelial cell that has an eccentric, round, or irregularly shaped hetero or euchromatic nucleus. The hallmark of this cell type is the presence of vacuoles, which are clustered in one area of the cytoplasm in the vicinity of the nucleus. The vacuoles are small and acquire a grape-like form, occasionally showing delicate internal microvillous projections." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T02:37:26Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:72214" ; oboInOwl:hasExactSynonym "cystic thymic epithelial cells", "large mTEC", "large medullary thymic epithelial cells" ; a owl:Class ; rdfs:label "type-6 epithelial cell of thymus" ; rdfs:subClassOf obo:CL_0002365 . obo:CL_0002296 obo:IAO_0000115 "An epithelial cell with high nuclear and cytoplasmic electron-density. This cell type is found in the deeper portions of the cortex but is more abundant in the medulla of the thymus." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T02:37:45Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:72212" ; oboInOwl:hasExactSynonym "dark thymic epithelial cell" ; a owl:Class ; rdfs:label "type-4 epithelial cell of thymus" ; rdfs:subClassOf obo:CL_0002364, obo:CL_0002365 . obo:CL_0002297 obo:IAO_0000115 "A thymic epithelial cell with moderate nuclear and cytoplasmic electron-density. Scattered in the cortex, this cell type is predominant in the mid and deep cortex." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T02:37:51Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:72211" ; oboInOwl:hasExactSynonym "intermediate thymic epithelial cell" ; a owl:Class ; rdfs:label "type-3 epithelial cell of thymus" ; rdfs:subClassOf obo:CL_0002364 . obo:CL_0002298 obo:IAO_0000115 "A thymic epithelial cell type with low nuclear and cytoplasmic electrondensity; has a round, euchromatic nucleus and occurs in small groups at the corticomedullary junction or scattered singly in the medulla." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T02:37:54Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:72213" ; oboInOwl:hasExactSynonym "undifferentiated mTEC", "undifferentiated medullary thymic epithelial cell", "undifferentiated thymic epithelial cell" ; a owl:Class ; rdfs:label "type-5 epithelial cell of thymus" ; rdfs:subClassOf obo:CL_0002365 . obo:CL_0002299 obo:IAO_0000115 "An epithelial cell scattered in the cortex, predominant in the outer cortex with a large pale nucleus and a prominent nucleolus." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T02:37:58Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:72210" ; oboInOwl:hasExactSynonym "pale thymic epithelial cell" ; a owl:Class ; rdfs:label "type-2 epithelial cell of thymus" ; rdfs:subClassOf obo:CL_0002364 . obo:CL_0002300 obo:IAO_0000115 "A small medullary thymic epithelial cell with a spindle shape, often arranged in groups and connected to each other by large desmosomes and interdigitations. The cytoplasm is sparse, with scanty organelles and thick bundles of cytokeratin." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T03:23:25Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "spindle shaped mTEC", "spindle shaped medullary thymic epithelial cell" ; a owl:Class ; rdfs:label "type-7 epithelial cell of thymus" ; rdfs:subClassOf obo:CL_0002365 . obo:CL_0002301 obo:IAO_0000115 "A resident stromal cell located in the synovial membrane and responsible for the production of immune-related cytokines and chemokines. This cell type secretes glycoproteins and hyaluronic acid, has abundant granular endoplasmic reticulum, but contains fewer vacuoles and vesicles." ; terms:contributor , ; oboInOwl:creation_date "2010-09-13T03:39:14Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0003652", "FMA:66788" ; oboInOwl:hasExactSynonym "fibroblast-like synoviocyte", "synovial fibroblast" ; a owl:Class ; rdfs:comment "Type B synovial cells play a key role in the pathogenesis of chronic inflammatory diseases, such as rheumatoid arthritis, and are essential for the maintenance of normal joint functions. Fibroblast-like synoviocytes from different joints have different properties, which may contribute to the characteristic pattern of joint involvement in different types of arthritis." ; rdfs:label "type B synovial cell" ; rdfs:subClassOf obo:CL_0000214, obo:CL_0000499, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030213 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0001090 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002018 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002018 ] ) ] . obo:CL_0002302 obo:IAO_0000115 "A synovial cell that is macrophage-like, characterized by surface ruffles or lamellipodia, plasma membrane invaginations and associated micropinocytotic vesicles, Golgi apparatus and little granular endoplasmic reticulum." ; terms:contributor ; oboInOwl:creation_date "2010-09-13T03:39:17Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:66787" ; oboInOwl:hasExactSynonym "type A synoviocyte" ; a owl:Class ; rdfs:comment "Type A cells are usually round and located in the upper part of the synovial intima." ; rdfs:label "type A synovial cell" ; rdfs:subClassOf obo:CL_0000214, obo:CL_0000234, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002018 ], _:genid8380 . obo:CL_0002303 obo:IAO_0000115 "A cell that is part of pigmented ciliary epithelium. This cell type uptakes sodium and chloride ions from stromal interstitium and passes the ions to non-pigmented ciliary epithelial cells via gap junctions." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Pigmented ciliary epithelial cells, which are a type of pigment cell, have a crucial function within the eye's ciliary body. The ciliary body, located behind the iris, is one of the eye’s most vital structures and consists of two types of epithelial cells: the pigmented and the non-pigmented ciliary epithelial cells. The pigmented ciliary epithelial cells form the outer layer of the ciliary body and exhibit a black or brown pigmentation due to the melanin they contain. One key function of pigmented ciliary epithelial cells is to aid in the formation of aqueous humor, an intraocular fluid that nourishes the cornea and lens, and maintains intraocular pressure which is essential for the eye’s shape and light refraction. These cells facilitate this function in conjunction with the non-pigmented ciliary epithelial cells. Together, the pigmented and non-pigmented ciliary epithelial cells form a bilayer epithelium that allows the secretion of aqueous humor through a bi-directional fluid transport mechanism. Pigmented ciliary epithelial cells also contribute to the blood-aqueous barrier, a physiological frontier that controls the entry and exit of various substances from the blood to the aqueous humor and vice versa. The pigmentation in these cells, intensified by melanin, helps to absorb scattered light coming into the eye, reducing any potential damage and glare. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-09-13T04:09:27Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70606" ; oboInOwl:hasExactSynonym "PE cell" ; oboInOwl:inSubset cl:cellxgene_subset, cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "In a consensus model of unidirectional secretion, aqueous humour is formed by transferring solute, principally NaCl, from stroma to posterior chamber, with water passively following the osmotic gradient. Unidirectional secretion comprises three sequential steps. First, NaCl is transferred from the stromal interstitium into the pigmented ciliary epithelial (PE) cells. Second, solute passes from the PE into the non-pigmented ciliary epithelial (NPE) cells through gap junctions. Finally, NPE cells release Na+ and Cl− into the aqueous humour." ; rdfs:label "pigmented ciliary epithelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002303" ; rdfs:subClassOf obo:CL_0000529, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001778 ] . obo:CL_0002304 obo:IAO_0000115 "A cell that is part of non-pigmented ciliary epithelium. This cell type participates in aqueous humor formation by releasing solute, principally sodium and chloride ions received from pigmented epithelial cells via gap junctions, into the aqueous humor of the eye." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-09-13T04:09:31Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70607" ; oboInOwl:hasExactSynonym "NPE cell", "nonpigmented ciliary epithelial cell" ; oboInOwl:inSubset cl:cellxgene_subset, cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "In a consensus model of unidirectional secretion, aqueous humour is formed by transferring solute, principally NaCl, from stroma to posterior chamber, with water passively following the osmotic gradient. Unidirectional secretion comprises three sequential steps. First, NaCl is transferred from the stromal interstitium into the pigmented ciliary epithelial (PE) cells. Second, solute passes from the PE into the non-pigmented ciliary epithelial (NPE) cells through gap junctions. Finally, NPE cells release Na+ and Cl− into the aqueous humour." ; rdfs:label "non-pigmented ciliary epithelial cell" ; rdfs:subClassOf obo:CL_0000710, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001778 ] . obo:CL_0002305 obo:IAO_0000115 "An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH." ; oboInOwl:hasDbXref "FMA:70981", "KUPO:0001055" ; oboInOwl:hasExactSynonym "kidney distal tubule epithelial cell" ; oboInOwl:inSubset cl:cellxgene_subset, cl:kidney_upper_slim ; a owl:Class ; rdfs:label "epithelial cell of distal tubule" ; rdfs:subClassOf obo:CL_0002078, obo:CL_1000494, obo:CL_1000615, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004135 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004135 ] ) ] . obo:CL_0002306 obo:IAO_0000115 "An epithelial cell of the proximal tubule of the kidney." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:70973", "KUPO:0001044" ; oboInOwl:hasExactSynonym "kidney proximal tubule epithelial cell" ; oboInOwl:inSubset cl:cellxgene_subset, cl:kidney_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The vast majority of proximal tubule epithelial cells have a brush border, but there are rare exceptions." ; rdfs:label "epithelial cell of proximal tubule" ; rdfs:subClassOf obo:CL_0002078, obo:CL_1000494, obo:CL_1000615, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004134 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004134 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" . obo:CL_0002307 obo:IAO_0000115 "A brush border epithelial cell located in the proximal tubule of the kidney, essential for reabsorbing substances like glucose and amino acids from the glomerular filtrate. These cells also secrete organic ions, playing a crucial role in maintaining kidney homeostasis, including electrolyte and acid-base balance, and excreting metabolic waste." ; terms:contributor ; oboInOwl:creation_date "2010-09-14T11:29:20Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "The vast majority of proximal tubule epithelial cells have a brush border, but there are rare exceptions." ; rdfs:label "brush border cell of the proximal tubule" ; rdfs:subClassOf obo:CL_0000239, obo:CL_0002306 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002306 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005903 ] ) ] . obo:CL_0002308 obo:IAO_0000115 "An epithelial cell of a skin gland." ; terms:contributor ; oboInOwl:creation_date "2010-09-14T12:00:07Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70657" ; oboInOwl:hasExactSynonym "epithelial cell of gland of skin" ; a owl:Class ; rdfs:label "epithelial cell of skin gland" ; rdfs:subClassOf obo:CL_0002159, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002419 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002419 ] ) ] . obo:CL_0002309 obo:IAO_0000115 "A basophil chromphil cell of the anterior pitiutary gland that produce adrenocorticotropic hormone, melanocyte-stimulating hormone and lipotropin. This cell type is irregular in shape and has short dendritic processes which are inserted among other neighboring cells;" ; terms:contributor ; oboInOwl:creation_date "2010-09-14T02:08:23Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0002509", "FMA:83098", "MESH:D052680" ; a owl:Class ; rdfs:label "corticotroph" ; rdfs:subClassOf obo:CL_0000467, obo:CL_0000639 . obo:CL_0002310 obo:IAO_0000115 "An acidophil cell of the anterior pituitary gland that produces both prolactin and growth hormone." ; terms:contributor ; oboInOwl:creation_date "2010-09-14T02:25:34Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:83097" ; a owl:Class ; rdfs:label "mammosomatotroph" ; rdfs:subClassOf obo:CL_0000295, obo:CL_0000439, obo:CL_0000638 . obo:CL_0002311 obo:IAO_0000115 "An acidophilic cell of the anterior pituitary that produces prolactin." ; terms:contributor ; oboInOwl:creation_date "2010-09-14T02:30:57Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:83096" ; oboInOwl:hasExactSynonym "epsilon-acidophil", "lactotrope", "lactotroph", "lactotropic cell", "mammotrope", "mammotrophic cell", "mammotropic cell" ; a owl:Class ; rdfs:label "mammotroph" ; rdfs:subClassOf obo:CL_0000439, obo:CL_0000638 . obo:CL_0002312 obo:IAO_0000115 "An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." ; terms:contributor ; oboInOwl:creation_date "2010-09-14T02:33:09Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:83095", "MESH:D052683" ; oboInOwl:hasExactSynonym "somatotrope", "somatotropic cell", "somatrophic cell" ; a owl:Class ; rdfs:label "somatotroph" ; rdfs:subClassOf obo:CL_0000295, obo:CL_0000638 ; skos:prefLabel "somatotroph" . obo:CL_0002313 obo:IAO_0000115 "An ecto-epithelial cell of the prostate gland that secretes hormones." ; terms:contributor ; oboInOwl:creation_date "2010-09-14T03:01:58Z"^^xsd:dateTime ; oboInOwl:hasDbXref "CALOHA:TS-1280", "FMA:74390", "FMA:86774" ; oboInOwl:hasExactSynonym "glandular cell of prostate", "neuro-epithelial cell of prostate gland" ; a owl:Class ; rdfs:label "endocrine-paracrine cell of prostate gland" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0002159, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0046879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002159 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0046879 ] ) ] . obo:CL_0002314 obo:IAO_0000115 "An auditory epithelial support cell located in the vestibular epithelium that has many hallmarks of glial cells. This cell type express glial markers such as vimentin, S100, glutamate-aspartate transporter, low affinity neurotrophin receptor p75, glial fibrillary acidic protein, and proteolipid protein." ; terms:contributor ; oboInOwl:creation_date "2010-09-14T03:20:01Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:75809" ; a owl:Class ; rdfs:label "external supporting cell of vestibular epithelium" ; rdfs:subClassOf obo:CL_0002316 . obo:CL_0002315 obo:IAO_0000115 "An epithelial supporting cell located in the cochlea." ; terms:contributor ; oboInOwl:creation_date "2010-09-14T03:31:38Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:79796" ; a owl:Class ; rdfs:label "supporting cell of cochlea" ; rdfs:subClassOf obo:CL_0001035, obo:CL_0005014, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001844 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001844 ] ) ] . obo:CL_0002316 obo:IAO_0000115 "A supporting cell of the vestibular epithelium." ; terms:contributor ; oboInOwl:creation_date "2010-09-14T03:31:44Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:75607" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "supporting cell of vestibular epithelium" ; rdfs:subClassOf obo:CL_0005014, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001862 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001862 ] ) ] . obo:CL_0002317 obo:IAO_0000115 "An external limiting cell found in the vestibular epithelium." ; terms:contributor ; oboInOwl:creation_date "2010-09-14T03:33:50Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:75808" ; a owl:Class ; rdfs:label "external limiting cell of vestibular epithelium" ; rdfs:subClassOf obo:CL_0002316 . obo:CL_0002318 obo:IAO_0000115 "A mesothelial cell capable of circulating in the blood by first losing its squamous character. This cell can incorporate into the regenerating mesothelium." ; terms:contributor ; oboInOwl:creation_date "2010-09-15T10:47:11Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:86712" ; a owl:Class ; rdfs:label "peripheral blood mesothelial cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000081, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000077 ] . obo:CL_0002319 obo:IAO_0000115 "A cell that is part of the nervous system." ; terms:contributor ; oboInOwl:creation_date "2010-09-15T01:34:57Z"^^xsd:dateTime ; oboInOwl:hasDbXref "CALOHA:TS-2040", "FMA:70333" ; oboInOwl:inSubset cl:cellxgene_subset, cl:general_cell_types_upper_slim ; a owl:Class ; rdfs:label "neural cell" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ] ) ] ; skos:prefLabel "neural cell" . obo:CL_0002320 obo:IAO_0000115 "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." ; terms:contributor ; oboInOwl:creation_date "2010-09-15T03:01:54Z"^^xsd:dateTime ; oboInOwl:hasDbXref "CALOHA:TS-2096", "FMA:63875", "MESH:D003239", "ZFA:0009392" ; oboInOwl:inSubset cl:cellxgene_subset, cl:general_cell_types_upper_slim ; a owl:Class ; rdfs:label "connective tissue cell" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002384 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002384 ] ) ] ; skos:prefLabel "connective tissue cell" . obo:CL_0002321 obo:IAO_0000115 "A cell of the embryo." ; terms:contributor ; terms:description """Embryonic cells in metazoans, which include all multicellular animals, are biological units in their earliest developmental stages from conception until the organism is fully formed. They are derived from a fertilized egg, which undergoes a series of cell divisions to produce a multicellular organism. During the early phases of embryonic development, these cells exhibit pluripotency, meaning they possess the potential to differentiate into a diverse array of specialized cell types that constitute different body tissues and structures. The balance between cell proliferation and differentiation in embryonic cells is crucial for successful development. When cells continue to divide without differentiating, overgrowth may occur leading to conditions such as teratomas (tumors of embryonic cells). Conversely, if cell differentiation proceeds at the expense of cell proliferation, developmental anomalies could occur regarding size or mass of the organism or its parts. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-09-15T03:39:21Z"^^xsd:dateTime ; oboInOwl:hasDbXref "CALOHA:TS-0263", "FMA:82840", "WBbt:0007028", "ZFA:0007089" ; a owl:Class ; rdfs:label "embryonic cell (metazoa)" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002321" ; rdfs:subClassOf obo:CL_0000000 ; skos:prefLabel "embryonic cell (metazoa)" . obo:CL_0002322 obo:IAO_0000115 "A stem cell of embryonic origin." ; terms:contributor ; oboInOwl:creation_date "2010-09-15T03:44:35Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0001086", "CALOHA:TS-0263", "FMA:82841", "MESH:D053595" ; oboInOwl:hasExactSynonym "ESC" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "This is an in vitro cell type and may be removed in future releases. These cells are reportedly SSEA-4-positive, CD73-negative, and CD324-positive." ; rdfs:label "embryonic stem cell" ; rdfs:subClassOf obo:CL_0000034, obo:CL_0002321 . obo:CL_0002323 obo:IAO_0000115 "A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface." ; terms:contributor ; oboInOwl:creation_date "2010-09-20T10:13:37Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0000066" ; a owl:Class ; rdfs:label "amniocyte" ; rdfs:subClassOf obo:CL_0000349, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0000173 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000349 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0000173 ] ) ] . obo:CL_0002324 obo:IAO_0000115 "A myoepithelial cell that is part of a mammary gland and is located in the basal layer. During lactation, a basal-myoepithelial cell of mammary gland contracts under the stimulation of oxytocin. In humans, a basal-myoepithelial cell of mammary gland can be identified by high levels of CD49f and low levels of EpCAM." ; terms:contributor , , ; oboInOwl:creation_date "2010-09-20T11:42:14Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "basal myoepithelial cell", "basal-myoepithelial cell" ; oboInOwl:hasDbXref "CALOHA:TS-2378", "FMA:67800" ; oboInOwl:hasExactSynonym "myoepithelial cell of mammary gland" ; oboInOwl:hasNarrowSynonym "basal cell of lactiferous duct", "myoepithelial cell of lactiferous gland" ; oboInOwl:hasRelatedSynonym "B-Myo cell", "BM", "basal" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Due inconsistencies in naming this and other mammary gland epithelial cell types, several mammary gland experts gathered for a breast atlas annotation jamboree organized by Chan-Zuckerberg initiative. They agreed to label this cell type as basal-myoepithelial cell (and abbreviated: B-Myo cell)." ; rdfs:label "basal-myoepithelial cell of mammary gland" ; rdfs:subClassOf obo:CL_0000185, obo:CL_0002327 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000185 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ) ] . obo:CL_0002325 obo:IAO_0000115 "A milk-producing glandular epithelial cell that is part of a mammary gland alveolus and differentiates from a luminal adaptive secretory precursor cell during secretory differentiation (also termed lactogenesis I). Following secretory activation (also termed lactogenesis II), a lactocyte is involved in the synthesis and/or transport of milk constituents including proteins, oligosaccharides, lactose, micronutrients, fat, hormones, immunoglobulins, and cytokines into the lumen of the lactating mammary gland." ; terms:contributor , , ; oboInOwl:creation_date "2010-09-20T01:30:57Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "mammary alveolar cell" ; oboInOwl:hasDbXref "FMA:74506", "FMA:79866" ; oboInOwl:hasExactSynonym "epithelial cell of lactiferous gland", "lactaction-associated mammary epithelial cell", "lactation-derived mammary cell", "luminal cell of alveolus of lactiferous gland", "mammary alveolar epithelial cell", "mammary gland alveolar epithelial cell" ; oboInOwl:hasRelatedSynonym "LMC" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "lactocyte" ; rdfs:subClassOf obo:CL_0000314, obo:CL_0002159, obo:CL_1001586, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003214 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_4033057 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003214 ] ) ] . obo:CL_0002326 obo:IAO_0000115 "A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast." ; terms:contributor ; oboInOwl:creation_date "2010-09-20T01:37:53Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "mature luminal cell" ; oboInOwl:hasDbXref "FMA:73280" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "luminal epithelial cell of mammary gland" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000069, obo:CL_0002327, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0009116 ] . obo:CL_0002327 obo:IAO_0000115 "An epithelial cell of the mammary gland." ; terms:contributor ; oboInOwl:creation_date "2010-09-20T01:49:37Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004300" ; oboInOwl:hasExactSynonym "breast epithelial cell", "mammary epithelial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "mammary gland epithelial cell" ; rdfs:subClassOf obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ) ] . obo:CL_0002328 obo:IAO_0000115 "An epithelial cell of the bronchus." ; terms:contributor ; oboInOwl:creation_date "2010-09-20T02:00:00Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0002922" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "bronchial epithelial cell" ; rdfs:subClassOf obo:CL_0002202, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002031 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:CL_0002329 obo:IAO_0000115 "An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """The basal epithelial cells of the tracheobronchial tree are critical components found in the lining of the airway passages, including the trachea and bronchi. They are keratin-5-positive, nonciliated, cuboidal cells and typically tightly attached to the basement membrane. In humans, the proportion of basal cells in the respiratory epithelium gradually decreases going down the tracheobronchial tree: they represent approximately 34% of the cells in the trachea, 27% in the large airways, and 10% in the small airways, although it is worth noting that there are differences in the compositions of the tracheobronchial epithelia between different species. Basal epithelial cells serve as the basal layer of the tracheobronchial epithelium, providing both structural and regenerative support for the epithelial tissue that lines the upper regions of the respiratory tract. They serve as progenitor or stem cells that are capable of differentiating into multiple cell types, such as ciliated and secretory cells. This gives them a central role in homeostatic maintenance of the epithelium, and in repairing damaged epithelium after an injury or during disease. This regenerative capacity is crucial in maintaining the integrity of the tracheobronchial surface, especially given its continual exposure to inhaled irritants and microorganisms. In addition to their primary restorative function, basal epithelial cells are also involved in the initial immune response within the tracheobronchial tree. Equipped with pattern recognition receptors, these cells can identify and respond to pathogenic organisms, triggering an immune response and producing a range of inflammatory mediators, such as cytokines and chemokines, to help combat infections. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-09-20T02:10:36Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "basal epithelial cell of tracheobronchial tree" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002329" ; rdfs:subClassOf obo:CL_0002202 . obo:CL_0002330 obo:IAO_0000115 "An undifferentiated columnar cell of the bronchus epithelium" ; terms:contributor ; oboInOwl:creation_date "2010-09-20T02:17:58Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "undifferentiated cell of bronchus epithelium" ; rdfs:subClassOf obo:CL_0002328 . obo:CL_0002331 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_1000349 ; a owl:Class ; owl:deprecated true . obo:CL_0002332 obo:IAO_0000115 "A multi-ciliated epithelial cell located in the bronchus epithelium, characterized by a columnar shape and motile cilia on its apical surface." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-09-20T02:21:12Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "ciliated epithelial cell of the bronchus" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "multiciliated epithelial cell of the bronchus" ; rdfs:subClassOf obo:CL_0002145, obo:CL_0002328 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002031 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0031514 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0010007 ] ) ] . obo:CL_0002333 obo:IAO_0000115 "An adipocyte derived from a neural crest cell." ; terms:contributor ; oboInOwl:creation_date "2010-09-20T02:25:25Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "neural crest derived adipocyte" ; rdfs:subClassOf obo:CL_0000136, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000005 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000136 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] ) ] . obo:CL_0002334 obo:IAO_0000115 "An undifferentiated fibroblast that can be stimulated to form a fat cell." ; terms:contributor ; oboInOwl:creation_date "2010-09-20T02:31:53Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0001107" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "preadipocyte" ; rdfs:subClassOf obo:CL_0000057 . obo:CL_0002335 obo:IAO_0000115 "A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha)." ; terms:contributor ; oboInOwl:creation_date "2010-09-20T02:38:38Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "brown preadipocyte" ; rdfs:subClassOf obo:CL_0002334 . obo:CL_0002336 obo:IAO_0000115 "An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek." ; terms:contributor ; oboInOwl:creation_date "2010-09-20T02:52:54Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "buccal mucosa cell" ; rdfs:subClassOf obo:CL_0002261 . obo:CL_0002337 obo:IAO_0000115 "A stem cell found in the basal layer of the epidermis, hair follicle, and sebaceous gland, characterised by its quiescent nature, high proliferative potential, and capacity for long-term self-renewal. This cell maintains epidermal homeostasis by producing transit-amplifying cells that differentiate to replenish the stratified squamous epithelium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-09-20T03:07:03Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "KSC" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "keratinocyte stem cell" ; rdfs:subClassOf obo:CL_0000048, obo:CL_0000312, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0036334 ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-hair-follicle/v1.0/assets/2d-ftu-skin-hair-follicle.png" . obo:CL_0002338 obo:IAO_0000115 "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-positive, CD117-positive, CD122-positive,and CD161-positive." ; terms:contributor ; oboInOwl:creation_date "2010-09-21T10:06:53Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "p-NK" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily)." ; rdfs:label "CD56-positive, CD161-positive immature natural killer cell, human" ; rdfs:subClassOf obo:CL_0000823, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001381 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001874 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002344 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000823 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001381 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001874 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0002339 obo:IAO_0000115 "A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium." ; terms:contributor ; oboInOwl:creation_date "2010-09-20T03:21:06Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "CD133-positive prostate epithelial cell" ; a owl:Class ; rdfs:label "prostate stem cell" ; rdfs:subClassOf obo:CL_0000048, obo:CL_0002341 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000034 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:CL_0002340 obo:IAO_0000115 "The exocrine cell of the prostate, this epithelial cell secretes prostatic acid phosphotase and PSA, and is dependent on androgen hormones for survival." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-09-20T03:34:05Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "luminal cell of prostate epithelium" ; rdfs:subClassOf obo:CL_0002231 ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" . obo:CL_0002341 obo:IAO_0000115 "An undifferentiated cell of the prostate epithelium that lacks secretory activity." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-09-20T03:34:10Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "basal cell of prostate epithelium" ; rdfs:subClassOf obo:CL_0002231 ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" . obo:CL_0002342 obo:IAO_0000115 "A circulating endothelial cell of the phenotype CD146-positive, CD105-positive, CD45-negative. This cell type is indicative of recent vascular damage." ; terms:contributor ; oboInOwl:creation_date "2010-09-20T03:49:58Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "circulating endothelial cell" ; rdfs:subClassOf obo:CL_0000115 . obo:CL_0002343 obo:IAO_0000115 "A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-09-20T04:00:02Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "dNK cell", "decidual NK cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "decidual natural killer cell, human" ; rdfs:subClassOf obo:CL_0000349, obo:CL_0000824, obo:CL_4052028, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002450 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001483 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009766 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001024 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000824 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009766 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001024 ] ) ] . obo:CL_0002344 obo:IAO_0000115 "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." ; terms:contributor ; oboInOwl:creation_date "2010-09-20T04:33:11Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "p-NK" ; a owl:Class ; rdfs:comment "Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily)." ; rdfs:label "CD56-negative, CD161-positive immature natural killer cell, human" ; rdfs:subClassOf obo:CL_0000823, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001381 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001874 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000823 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001381 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001874 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_0002345 obo:IAO_0000115 "An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver." ; terms:contributor ; oboInOwl:creation_date "2010-09-20T04:41:01Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "preNK.BM" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "CD27-low, CD11b-low immature natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0000823, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001008 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002977 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009616 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002346 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001963 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000823 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001008 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002977 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009616 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001963 ] ) ] . obo:CL_0002346 obo:IAO_0000115 "An immature natural killer cell that is NK1.1-positive and DX-5 negative." ; terms:contributor ; oboInOwl:creation_date "2010-09-21T10:11:44Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Dx5-negative, NK1.1-positive immature natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0000823, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001008 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002977 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000823 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001008 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002977 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] ) ] . obo:CL_0002347 obo:IAO_0000115 "A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion." ; terms:contributor ; oboInOwl:creation_date "2010-09-21T10:19:49Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "CD27-high, CD11b-high natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0000824, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002349 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001963 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000824 [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001963 ] ) ] . obo:CL_0002348 obo:IAO_0000115 "A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors." ; terms:contributor ; oboInOwl:creation_date "2010-09-21T10:19:54Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "CD27-low, CD11b-high natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0000824, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002347 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001963 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000824 [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001963 ] ) ] . obo:CL_0002349 obo:IAO_0000115 "A natural killer cell that is CD27-high and CD11b-low." ; terms:contributor ; oboInOwl:creation_date "2010-09-21T10:20:00Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "CD27-high, CD11b-low natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0000824, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002345 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001963 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000824 [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001963 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ] ) ] . obo:CL_0002350 obo:IAO_0000115 "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Endocardial cells, often referred to as endothelial cells of the heart, constitute the innermost lining layer of the heart tissues, forming the endocardium. They play a critical role in maintaining heart functionality and homeostasis. These cells, flat and squamous in structure, are adjoined closely to form a tight barrier that separates the heart's muscular layer, the myocardium, from the blood flowing through the heart chambers. Functionally, endocardial cells are key players in several crucial physiological processes within the heart. Synthesizing matrix molecules that contribute to the structural formation of the heart, these cells actively partake in maintaining its structural integrity. They also exhibit unique metabolic activity, which aids in maintaining optimal cardiac functioning in both healthy and pathological conditions. Importantly, they are known for their involvement in modulating myocardial contraction and relaxation, that is crucial for normal heart rhythm and function. They achieve this by producing factors like nitric oxide (NO) which, amongst other things, aids in the regulation of blood pressure, prevents blood clotting and inhibits the adherence of blood cells to the vessel wall. In pathological states, endocardial cells can undergo a transformation process known as endothelial-mesenchymal transition (EndMT), which is inherently involved in several cardiac diseases. In this transition, they acquire the ability to migrate and differentiate into several other types of cells contributing to disease progression. Moreover, their dysfunction can lead to endocarditis, an inflammation of the endocardium, as well as increase the risk of other heart diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-09-21T04:33:05Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:75621" ; oboInOwl:hasExactSynonym "endocardial endothelial cell", "endothelial cell of endocardium" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "endocardial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002350" ; rdfs:subClassOf obo:CL_0010008, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002165 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002165 ] ) ] . obo:CL_0002351 obo:IAO_0000115 "A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." ; terms:contributor ; oboInOwl:creation_date "2010-09-21T04:41:06Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "pancreatic endocrine progenitor", "pancreatic islet progenitor cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "progenitor cell of endocrine pancreas" ; rdfs:subClassOf obo:CL_0011026 . obo:CL_0002352 obo:IAO_0000115 "A hematopoietic stem cell that exists during embryogenesis." ; terms:contributor ; oboInOwl:creation_date "2010-09-22T09:05:13Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "gestational hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0000037, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] ) ] . obo:CL_0002353 obo:IAO_0000115 "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative." ; terms:contributor ; oboInOwl:creation_date "2010-09-22T09:08:32Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "fetal liver hematopoietic progenitor cell" ; rdfs:subClassOf obo:CL_0002352, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001308 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001896 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042611 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001833 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002352 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001308 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001896 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042611 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001833 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ] ) ] . obo:CL_0002354 obo:IAO_0000115 "A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive." ; terms:contributor ; oboInOwl:creation_date "2010-09-22T09:08:34Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "hemangioblast precursor" ; a owl:Class ; rdfs:label "yolk sac hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0002352, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001040 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042611 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001006 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002352 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042611 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001006 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] ) ] . obo:CL_0002355 obo:IAO_0000115 "A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation." ; terms:contributor ; oboInOwl:creation_date "2010-09-22T09:27:05Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "primitive erythroblast", "primitive erythrocyte", "primitive erythroid cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "primitive red blood cell" ; rdfs:subClassOf obo:CL_0002417, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000008467 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000008857 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000586 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002361 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002417 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000008467 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000008857 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000586 ] ) ] . obo:CL_0002356 obo:IAO_0000115 "A primitive erythrocyte that has undergone enucleation. This cell type is 3-6 fold bigger than the fetal derived erythrocytes that they co-circulate with during fetal development. Expresses epsilon-gamma hemoglobin chains." ; terms:contributor ; oboInOwl:creation_date "2010-09-22T09:35:16Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "megalocyte" ; a owl:Class ; rdfs:label "primitive reticulocyte" ; rdfs:subClassOf obo:CL_0002417, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000586 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002355 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002417 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000586 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002355 ] ) ] . obo:CL_0002357 obo:IAO_0000115 "A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins." ; terms:contributor ; oboInOwl:creation_date "2010-09-22T09:38:32Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "macrocyte" ; a owl:Class ; rdfs:label "fetal derived definitive erythrocyte" ; rdfs:subClassOf obo:CL_0000595, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000008857 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002353 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000595 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000008857 ] ) ] . obo:CL_0002358 obo:IAO_0000115 "Derived from the Greek word pyren (the pit of a stone fruit), this is a transient nucleated cell type that results from exclusion of the nucleus from the primitive erythrocyte." ; terms:contributor ; oboInOwl:creation_date "2010-09-22T10:02:37Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "pyrenocyte" ; rdfs:subClassOf obo:CL_0002417, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000587 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002355 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002417 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000587 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002355 ] ) ] . obo:CL_0002359 obo:IAO_0000115 "A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells." ; terms:contributor ; oboInOwl:creation_date "2010-09-22T10:30:02Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "placental hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0002352, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:CL_0002360 obo:IAO_0000115 "A hematopoietic stem cell from the aorta-gonad-mesonephros region of the developing embryo. First seen at E10.5 in mouse embryos. May give rise to fetal liver HSC." ; terms:contributor ; oboInOwl:creation_date "2010-09-22T10:31:49Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "AGM hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0002352 . obo:CL_0002361 obo:IAO_0000115 "A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41." ; terms:contributor ; oboInOwl:creation_date "2010-09-22T10:47:28Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "EryP-CFC", "inner blood island hemangioblast" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "primitive erythroid progenitor" ; rdfs:subClassOf obo:CL_0002417, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009127 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002418 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002417 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009127 ] ) ] . obo:CL_0002362 obo:IAO_0000115 "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive." ; terms:contributor ; oboInOwl:creation_date "2010-09-22T01:40:44Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "granule cell precursor", "granule cell progenitor" ; oboInOwl:hasRelatedSynonym "GCP" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cerebellar granule cell precursor" ; rdfs:subClassOf obo:CL_0000031, obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009841 ] ; skos:prefLabel "cerebellar granule cell precursor" . obo:CL_0002363 obo:IAO_0000115 "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-09-22T01:57:40Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "corneal fibroblast", "corneal keratocyte" ; oboInOwl:inSubset cl:cellxgene_subset, cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "keratocyte" ; rdfs:subClassOf obo:CL_0000005, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001777 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001777 ] ) ] . obo:CL_0002364 obo:IAO_0000115 "An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Cortical thymic epithelial cells (cTECs) are a vital cell type located in the thymus, a lymphoid organ that plays a key role in the development of T cells, which are essential for the adaptive immune system. cTECs also have a role in forming barriers and lining surfaces. In the thymus, their presence contributes to the distinctive architecture of both the cortex and medulla. cTECs also play a significant part in the selection and development of T cells. During T cell maturation, these cells express both self and non-self proteins via the major histocompatibility complex (MHC) to immature T cells. cTECs then stimulate the T cells that can recognize such proteins, an important event known as positive selection. This process aids in the creation of a diverse T cell receptor (TCR) repertoire that can react to a wide range of antigens, therefore ensuring effective immunity. Apart from aiding in T cells' positive selection, cTECs also contribute to eliminating self-reactive T cells, a role essential in preventing autoimmune diseases. These cells induce an apoptosis-driven process known as \"negative selection\" which eliminates T cells that are too highly reactive to self-antigens. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-09-23T03:17:12Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004562" ; oboInOwl:hasExactSynonym "cTEC" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "cortical thymic epithelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002364" ; rdfs:subClassOf obo:CL_0002293, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002123 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002123 ] ) ] . obo:CL_0002365 obo:IAO_0000115 "An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output." ; terms:contributor ; terms:description """Medullary thymic epithelial cells (mTECs) are distinct cells situated in the thymic medulla, a vital organ where T cells mature. mTECs are recognized by their unique appearance, characterized by large, plump cells with abundant cytoplasm and irregularly shaped nuclei. They inhabit a microenvironment closely interacting with various thymic cell types, including conventional dendritic cells and thymocytes. The primary function of mTECs revolves around negative selection of developing T cells, thus preventing autoimmune responses. mTECs allow developing T cells to recognize and be responsive to foreign antigens while remaining tolerant to the body's own tissues. They achieve this through a process called promiscuous gene expression where they express and display a vast array of self-antigens. This process is regulated by a transcriptional regulator called autoimmune regulator (Aire), which contributes to immunological self-tolerance. mTECs themselves have a self-renewing ability and sustain the continuous export of mature T cells. They also express a number of genes that encode for chemokines and other signaling molecules which draw in and retain developing T cells for the process of negative selection. The three-dimensional network formed by these cells provides a physical platform for such selection. Together, mTECs hold a critical place in the maintenance of immune homeostasis, demonstrating the conceptual links that exist between population of stromal cells, thymocytes development, tissue-restricted antigen expression, and negative selection. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-09-23T03:17:14Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004563" ; oboInOwl:hasExactSynonym "mTEC" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "medullary thymic epithelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002365" ; rdfs:subClassOf obo:CL_0002293, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002124 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002124 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" . obo:CL_0002366 obo:IAO_0000115 "A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin." ; terms:contributor ; terms:description """Myometrial cells are specialized smooth muscle cells located in the myometrium, the middle layer of the uterine wall. Unique to female reproductive physiology, they play a key role in pregnancy and childbirth. These cells are distinctive in their capability to substantially increase in size and number during pregnancy, preparing the uterus to accommodate the growing fetus. As pregnancy progresses, myometrial cells demonstrate a progressive growth in uterine mass through cellular hypertrophy. They are also responsible for the production of extracellular matrix proteins like collagen, which aids in supporting cell structure and function, further facilitating uterine enlargement. During childbirth, myometrial cells are responsible for the expansion and contraction of the uterus. They can propagate action potentials and generate considerable force, which is critical to their function in the reproductive system. After pregnancy, these cells can reduce in size, a process known as uterine involution. Given the important role these cells play in female reproductive physiology, dysregulation of the myometrial cell function can contribute to uterine pathologies such as uterine fibroids. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-09-23T03:46:34Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004519" ; oboInOwl:hasExactSynonym "myometrium smooth muscle cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "myometrial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002366" ; rdfs:subClassOf obo:CL_0002601, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001296 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001296 ] ) ] . obo:CL_0002367 obo:IAO_0000115 "A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure." ; terms:contributor ; oboInOwl:creation_date "2010-09-23T04:18:50Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "trabeculocyte" ; a owl:Class ; rdfs:label "trabecular meshwork cell" ; rdfs:subClassOf obo:CL_0000115, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005969 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005969 ] ) ] . obo:CL_0002368 obo:IAO_0000115 "An epithelial cell of the respiratory tract epithelium. These cells have an endodermal origin." ; terms:contributor ; oboInOwl:creation_date "2010-09-23T04:38:49Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004533" ; oboInOwl:hasExactSynonym "airway epithelial cell", "respiratory epithelial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "respiratory tract epithelial cell" ; rdfs:subClassOf obo:CL_0002076, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004802 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004802 ] ) ] ; skos:prefLabel "respiratory tract epithelial cell" . obo:CL_0002369 obo:IAO_0000115 "A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions." ; terms:contributor ; oboInOwl:creation_date "2010-10-01T09:02:42Z"^^xsd:dateTime ; oboInOwl:hasDbXref "MESH:D013172" ; a owl:Class ; rdfs:label "fungal spore" ; rdfs:subClassOf obo:CL_0000521 . obo:CL_0002370 obo:IAO_0000115 "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion." ; terms:contributor ; terms:description """The respiratory goblet cell is a highly specialized cell type found primarily within the respiratory tract, including the nose, trachea, and lungs. Named because their shape resembles a goblet - a drinking vessel with a wide body and narrow neck - these cells form a vital part of the respiratory system's protective mechanisms. They are found within the columnar epithelium lining these organs, which forms a barrier between the internal body and the exterior environment. A principal function of the respiratory goblet cell is the production and secretion of mucus, a carbohydrate-rich, viscous and gel-like substance that plays a critical role in trapping dust, bacteria, viruses, and other airborne particles that are inhaled. The mucus secreted by the goblet cells covers the lining of the respiratory tract, effectively catching these particles and preventing them from reaching the lungs and causing infection. Mucus also provides hydration and lubrication to the respiratory tract surfaces, which is important in maintaining the tissue's health and functioning. In addition to their mucus-secreting capabilities, respiratory goblet cells also play a significant role in the body's inflammatory responses. When the respiratory system is exposed to irritants or pathogens, the number and activity of goblet cells often increase, leading to a higher production of mucus. This is a protective response designed to trap and neutralize the harmful substances more effectively. However, in conditions like chronic obstructive pulmonary disease (COPD) and asthma, an overproliferation of goblet cells, also known as goblet cell hyperplasia, can lead to excessive mucus production and airway obstruction. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-09-23T04:42:27Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "respiratory goblet cell", "respiratory mucosa goblet cells" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "respiratory tract goblet cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002370" ; rdfs:subClassOf obo:CL_0000160, obo:CL_0008055 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004802 ] ) ] . obo:CL_0002371 obo:IAO_0000115 "OBSOLETE. A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell)." ; obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000000 ; terms:contributor ; terms:description """Somatic cells represent the majority of the cell types in the human body. They are fundamental building blocks of organs, tissues, and other bodily structures, with every organ being composed of distinct subpopulations of these cells. The primary function of somatic cells is to maintain the function and survival of an organism. They carry significant information in the form of DNA, and through the process of mitosis, contribute to the repair and regeneration of body tissues. Further, some types of somatic cells work in a collaborative manner to form complex functional structures such as the skin and lining of the gut, demonstrating a higher level of organization. However, it's important to note that somatic cells are distinct from germ cells, which are responsible for sexual reproduction by forming sperm or eggs. Any alterations in the DNA of somatic cells, due to mutations, will not affect the offspring as they aren't involved in transmission of genetic information to the next generation. While most somatic cells contain two copies of each chromosome (diploid), a certain subset may possess a single set of chromosomes (haploid), specifically found in male ants, bees, and other hymenopterans. Hence, diversity is a defining characteristic of somatic cells, reflecting in their structures, roles, and genetic makeup. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2010-09-24T09:44:42Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0001268", "FMA:72300", "WBbt:0008378" ; oboInOwl:inSubset ubprop:_upper_level ; a owl:Class ; rdfs:label "obsolete somatic cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002371" ; owl:deprecated true . obo:CL_0002372 obo:IAO_0000115 "A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development." ; terms:contributor ; oboInOwl:creation_date "2010-09-24T01:13:01Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FBbt:00005812" ; oboInOwl:hasExactSynonym "myofiber", "myofibril" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "myotube" ; rdfs:subClassOf obo:CL_0000737, obo:CL_4052002, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002478 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002478 ] ) ] ; skos:prefLabel "myotube" . obo:CL_0002373 obo:IAO_0000115 "A peptide hormone secreting cell that secretes growth hormone releasing hormone." ; terms:contributor ; oboInOwl:creation_date "2010-09-24T01:36:44Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "GHRH secreting cell", "somatocrinin secreting cell" ; a owl:Class ; rdfs:label "growth hormone releasing hormone secreting cell" ; rdfs:subClassOf obo:CL_0000167 . obo:CL_0002374 obo:IAO_0000115 "A hair cell of the ear that contains the organs of balance and hearing." ; terms:contributor ; oboInOwl:creation_date "2010-09-24T01:49:31Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "ear receptor cell" ; a owl:Class ; rdfs:label "ear hair cell" ; rdfs:subClassOf obo:CL_0000006, obo:CL_0000855, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001690 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000855 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001690 ] ) ] . obo:CL_0002375 obo:IAO_0000115 "A multipotent progenitor cell that develops from a migratory neural crest cell. The schwann cell precursor is embedded among axons, with minimal extracellular space separating them from nerve cell membranes. This cell lacks a basal lamina, which distinguishes it from more mature Schwann cells. In rodents, cadherin-19 (Cdh19) serves as a specific marker for this developmental stage." ; terms:contributor ; oboInOwl:creation_date "2010-09-24T02:06:10Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Schwann cell precursor cell" ; oboInOwl:hasRelatedSynonym "SCP" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Schwann cell precursor are capable of differentiating into Schwann cells and other cell types such as melanocytes, neurons, and mesenchymal cells." ; rdfs:label "Schwann cell precursor" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:CL_0002573 ] . obo:CL_0002376 obo:IAO_0000115 "A glial cell that ensheaths multiple small diameter axons in the peripheral nervous system. The non-myelinating Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. These cells can de-differentiate into immature Schwann cells." ; terms:contributor ; oboInOwl:creation_date "2010-09-24T02:10:26Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "Schwann cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "non-myelinating Schwann cell" ; rdfs:subClassOf obo:CL_0002573, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002377 ] . obo:CL_0002377 obo:IAO_0000115 "A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons." ; terms:contributor ; oboInOwl:creation_date "2010-09-24T02:10:31Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "Schwann cell" ; oboInOwl:hasDbXref "ZFA:0001725" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "immature Schwann cell" ; rdfs:subClassOf obo:CL_0002573, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002375 ] . obo:CL_0002378 obo:IAO_0000115 "A double negative thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive and is found in the fetal thymus." ; terms:contributor ; oboInOwl:creation_date "2010-10-07T02:21:07Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "fetal Vgamma2+ thymocyte" ; a owl:Class ; rdfs:comment "NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments." ; rdfs:label "immature Vgamma2-positive fetal thymocyte" ; rdfs:subClassOf obo:CL_0002404 . obo:CL_0002379 obo:IAO_0000115 "A neurecto-epithelial cell found in the arachnoid villi of dura mater. This cell type facilitates flow of cerebrospinal fluid into the blood." ; terms:contributor ; oboInOwl:creation_date "2010-09-28T02:23:46Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:86588" ; oboInOwl:hasExactSynonym "arachnoid cap cell" ; a owl:Class ; rdfs:label "meningothelial cell" ; rdfs:subClassOf obo:CL_0000710 . obo:CL_0002380 obo:IAO_0000115 "An asexual spore formed by Oomycetes; formed upon fertilization of an oosphere." ; terms:contributor ; oboInOwl:creation_date "2010-10-01T09:22:45Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FAO:0000039" ; a owl:Class ; rdfs:label "oospore" ; rdfs:subClassOf obo:CL_0000605 . obo:CL_0002381 obo:IAO_0000115 "A conidium that has only one nucleus." ; terms:contributor ; oboInOwl:creation_date "2010-10-01T09:26:39Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FAO:0000025" ; a owl:Class ; rdfs:label "uninucleate conidium" ; rdfs:subClassOf obo:CL_0000599 . obo:CL_0002382 obo:IAO_0000115 "A conidium that has more than one nucleus." ; terms:contributor ; oboInOwl:creation_date "2010-10-01T09:31:28Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FAO:0000033" ; a owl:Class ; rdfs:label "multinucleate conidium" ; rdfs:subClassOf obo:CL_0000599 . obo:CL_0002383 obo:IAO_0000115 "A uninucleate spore formed on specialized cells or projections, sterigma, of a conidiophore head." ; oboInOwl:hasDbXref "FAO:0000033" ; a owl:Class ; rdfs:label "conidium of conidiophore head" ; rdfs:subClassOf obo:CL_0002381 . obo:CL_0002384 obo:IAO_0000115 "A macroconidium that has only one nucleus." ; oboInOwl:hasDbXref "FAO:0000029" ; a owl:Class ; rdfs:label "uninucleate macroconidium" ; rdfs:subClassOf obo:CL_0000606, obo:CL_0002381 . obo:CL_0002385 obo:IAO_0000115 "An oblong or round asexual spore formed from conidial chains." ; oboInOwl:hasDbXref "BTO:0000127", "FAO:0000042" ; oboInOwl:hasRelatedSynonym "blastospore" ; a owl:Class ; rdfs:label "blastoconidium" ; rdfs:subClassOf obo:CL_0000606 . obo:CL_0002386 obo:IAO_0000115 "A macroconidium that has more than one nucleus." ; oboInOwl:hasDbXref "FAO:0000035" ; a owl:Class ; rdfs:label "multinucleate macroconidium" ; rdfs:subClassOf obo:CL_0000606, obo:CL_0002382 . obo:CL_0002387 obo:IAO_0000115 "Cylindrical spore formed by development and compartmentation of hyphae; the hyphae are often supporting blastoconidiophores." ; oboInOwl:hasDbXref "FAO:0000041" ; oboInOwl:hasRelatedSynonym "arthrospore" ; a owl:Class ; rdfs:label "arthroconidium" ; rdfs:subClassOf obo:CL_0000606 . obo:CL_0002388 obo:IAO_0000115 "An arthroconidium that has more than one nucleus." ; oboInOwl:hasDbXref "FAO:0000037" ; a owl:Class ; rdfs:label "multinucleate arthroconidium" ; rdfs:subClassOf obo:CL_0002386, obo:CL_0002387 . obo:CL_0002389 obo:IAO_0000115 "An arthroconidium that has only one nucleus." ; oboInOwl:hasDbXref "FAO:0000031" ; a owl:Class ; rdfs:label "uninucleate arthroconidium" ; rdfs:subClassOf obo:CL_0002384, obo:CL_0002387 . obo:CL_0002390 obo:IAO_0000115 "A blastoconidium that has only one nucleus." ; oboInOwl:hasDbXref "FAO:0000030" ; a owl:Class ; rdfs:label "uninucleate blastconidium" ; rdfs:subClassOf obo:CL_0002384, obo:CL_0002385 . obo:CL_0002391 obo:IAO_0000115 "A blastoconidium that has more than one nucleus." ; oboInOwl:hasDbXref "FAO:0000036" ; a owl:Class ; rdfs:label "multinucleate blastoconidium" ; rdfs:subClassOf obo:CL_0002385, obo:CL_0002386 . obo:CL_0002392 obo:IAO_0000115 "Obsolete. Use PO:0025017 from Plant Ontology instead. A plant cell that arises through meiosis and develops into a gametophyte." ; obo:IAO_0100001 obo:PO_0025017 ; a owl:Class ; rdfs:label "obsolete plant spore" ; owl:deprecated true . obo:CL_0002393 obo:IAO_0000115 "A monocyte that has characteristics of both patrolling and inflammatory monocytes." ; terms:contributor ; oboInOwl:creation_date "2010-10-04T10:52:03Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "intermediate monocyte" ; rdfs:subClassOf obo:CL_0000576, [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0030224 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001199 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000860 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000576 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0030224 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001199 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] ) ] . obo:CL_0002394 obo:IAO_0000115 "A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-10-04T02:38:58Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Markers are found in human cells. Normally they represent 3-5% of peripheral blood mDCs (human). These cells express high levels of CD283 (TLR3), are capable of producing IL-12p70 and IFN-beta upon stimulation, and inducing a TH1 response [PMCID:PMC2882828]. They are also Necl2-positive. May be human equivalent of murine CD8-alpha-positive DCs." ; rdfs:label "CD141-positive myeloid dendritic cell" ; rdfs:subClassOf obo:CL_0000782, obo:CL_0000784, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002105 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002827 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042590 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000782 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002827 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032606 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042590 ] ) ] . obo:CL_0002395 obo:IAO_0000115 "A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative." ; terms:contributor ; oboInOwl:creation_date "2010-10-04T11:26:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product." ; rdfs:label "Gr1-high classical monocyte" ; rdfs:subClassOf obo:CL_0000860, obo:CL_0001022, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001014 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001206 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002980 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000860 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001206 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002980 ] ) ] . obo:CL_0002396 obo:IAO_0000115 "A patrolling monocyte that is CD14-low and CD16-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-10-04T12:25:42Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "non-classical monocyte, human" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Markers are associated with human monocytes." ; rdfs:label "CD14-low, CD16-positive monocyte" ; rdfs:subClassOf obo:CL_0000875, obo:CL_0001054, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002397 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001889 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000875 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001889 ] ) ] . obo:CL_0002397 obo:IAO_0000115 "A CD14-positive monocyte that is also CD16-positive and CCR2-negative." ; terms:contributor ; oboInOwl:creation_date "2010-10-04T12:49:47Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "CD16+ monocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+)." ; rdfs:label "CD14-positive, CD16-positive monocyte" ; rdfs:subClassOf obo:CL_0001054, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001199 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001054 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001199 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ] ) ] . obo:CL_0002398 obo:IAO_0000115 "An intermediate monocyte that is Gr1-positive, CD43-positive." ; terms:contributor ; oboInOwl:creation_date "2010-10-04T12:49:49Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Gr1-positive, CD43-positive monocyte" ; rdfs:subClassOf obo:CL_0001022, obo:CL_0002393, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002980 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002395 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000576 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002980 ] ) ] . obo:CL_0002399 obo:IAO_0000115 "A myeloid dendritic cell that is CD1c-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-10-04T02:39:01Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Normally represent 10-20% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10) [PMID:20204387]. Upon TLR stimulation, these cells were potent producers of CXCL8 (IL-8), while producing little TNF-alpha." ; rdfs:label "CD1c-positive myeloid dendritic cell" ; rdfs:subClassOf obo:CL_0000782, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002027 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032637 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000782 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002027 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032637 ] ) ] . obo:CL_0002400 obo:IAO_0000115 "A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive." ; terms:contributor ; oboInOwl:creation_date "2010-10-05T10:11:38Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "fraction B/C precursor B cell" ; rdfs:subClassOf obo:CL_0000817, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000817 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] ) ] . obo:CL_0002401 obo:IAO_0000115 "A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." ; terms:contributor ; oboInOwl:creation_date "2010-10-07T02:05:46Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "mature DEC precursor", "mature DETC precursor" ; a owl:Class ; rdfs:comment "NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments." ; rdfs:label "mature dendritic epithelial T cell precursor" ; rdfs:subClassOf obo:CL_0002404, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002218 ] . obo:CL_0002402 obo:IAO_0000115 "A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative." ; terms:contributor ; oboInOwl:creation_date "2010-10-05T11:18:03Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Peyers patch B cell" ; a owl:Class ; rdfs:label "Peyer's patch B cell" ; rdfs:subClassOf obo:CL_0000822, obo:CL_0009014, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002037 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001338 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001211 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001338 ] ) ] . obo:CL_0002403 obo:IAO_0000115 "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." ; terms:contributor ; oboInOwl:creation_date "2010-10-07T02:24:36Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "fetal Vgamma2-positive" ; a owl:Class ; rdfs:comment "NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments." ; rdfs:label "mature Vgamma2-positive fetal thymocyte" ; rdfs:subClassOf obo:CL_0002404, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002378 ] . obo:CL_0002404 obo:IAO_0000115 "A thymocyte found in the fetal thymus." ; terms:contributor ; oboInOwl:creation_date "2010-10-07T02:28:25Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "fetal thymocyte" ; rdfs:subClassOf obo:CL_0000893 . obo:CL_0002405 obo:IAO_0000115 "A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative)." ; terms:contributor ; oboInOwl:creation_date "2010-10-07T02:33:39Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "gammadelta thymocyte", "gd thymocyte" ; a owl:Class ; rdfs:label "gamma-delta thymocyte" ; rdfs:subClassOf obo:CL_0000798, obo:CL_0002489 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000893 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042106 ] ) ] . obo:CL_0002406 obo:IAO_0000115 "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive." ; terms:contributor ; oboInOwl:creation_date "2010-10-07T02:53:44Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "Vgamma2-positive thymocyte" ; a owl:Class ; rdfs:comment "NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments." ; rdfs:label "immature Vgamma2-positive thymocyte" ; rdfs:subClassOf obo:CL_0002405 . obo:CL_0002407 obo:IAO_0000115 "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative." ; terms:contributor ; oboInOwl:creation_date "2010-10-07T02:53:48Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Vgamma2-positive" ; a owl:Class ; rdfs:comment "NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments." ; rdfs:label "mature Vgamma2-positive thymocyte" ; rdfs:subClassOf obo:CL_0002405, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002406 ] . obo:CL_0002408 obo:IAO_0000115 "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain that does not contain a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive." ; terms:contributor ; oboInOwl:creation_date "2010-10-07T02:59:05Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "Vgamma2-negative thymocyte" ; a owl:Class ; rdfs:comment "NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments." ; rdfs:label "immature Vgamma2-negative thymocyte" ; rdfs:subClassOf obo:CL_0002405 . obo:CL_0002409 obo:IAO_0000115 "A thymocyte that has a T cell receptor consisting of a gamma chain that does not contain the Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative." ; terms:contributor ; oboInOwl:creation_date "2010-10-07T02:59:08Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Vgamma2-negative" ; a owl:Class ; rdfs:comment "NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments." ; rdfs:label "mature Vgamma2-negative thymocyte" ; rdfs:subClassOf obo:CL_0002405, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002408 ] . obo:CL_0002410 obo:IAO_0000115 "A cell that is found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and has long cytoplasmic processes that encircle the base of the acinus. Expresses several intermediate filament proteins including vimentin and nestin. Shares many of the characteristics of hepatatic stellate cells, but not stellate cells of the central nervous system. Upon activation, this cell type undergoes morphological and gene expression changes that make the cell suggestive of being a type of myofibroblast." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-11-10T09:40:33Z"^^xsd:dateTime ; oboInOwl:hasDbXref "MESH:D058954" ; oboInOwl:hasExactSynonym "PaSC", "pancreas stellate cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreatic stellate cell" ; rdfs:subClassOf obo:CL_0000057, obo:CL_0002574 . obo:CL_0002411 obo:IAO_0000115 "A gamma-delta receptor that expresses Vgamma1.1 but does not express Vdelta6.3 chains in the T-cell receptor." ; terms:contributor ; oboInOwl:creation_date "2010-10-07T03:07:44Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Vg1.1-positive, Vd6.3-negative T cell" ; a owl:Class ; rdfs:label "Vgamma1.1-positive, Vdelta6.3-negative thymocyte" ; rdfs:subClassOf obo:CL_0002405 . obo:CL_0002412 obo:IAO_0000115 "A gamma-delta receptor that expresses Vgamma1.1-Vdelta6.3 chains in the T-cell receptor." ; terms:contributor ; oboInOwl:creation_date "2010-10-07T03:03:00Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Vg1.1+Vd6.3+ T cell" ; a owl:Class ; rdfs:label "Vgamma1.1-positive, Vdelta6.3-positive thymocyte" ; rdfs:subClassOf obo:CL_0002405 . obo:CL_0002413 obo:IAO_0000115 "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-negative." ; terms:contributor ; oboInOwl:creation_date "2010-10-07T03:10:32Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "mature Vg1.1-positive, Vd6.3-negative T cell" ; a owl:Class ; rdfs:label "mature Vgamma1.1-positive, Vdelta6.3-negative thymocyte" ; rdfs:subClassOf obo:CL_0002411 . obo:CL_0002414 obo:IAO_0000115 "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-positive." ; terms:contributor ; oboInOwl:creation_date "2010-10-07T03:10:35Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "immature Vg1.1-positive, Vd6.3-negative T cell" ; a owl:Class ; rdfs:label "immature Vgamma1.1-positive, Vdelta6.3-negative thymocyte" ; rdfs:subClassOf obo:CL_0002411 . obo:CL_0002415 obo:IAO_0000115 "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-positive." ; terms:contributor ; oboInOwl:creation_date "2010-10-07T03:10:39Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "immature Vg1.1+Vd6.3+ T cell" ; a owl:Class ; rdfs:label "immature Vgamma1.1-positive, Vdelta6.3-positive thymocyte" ; rdfs:subClassOf obo:CL_0002412 . obo:CL_0002416 obo:IAO_0000115 "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-negative." ; terms:contributor ; oboInOwl:creation_date "2010-10-07T03:10:41Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "mature Vg1.1+Vd6.3+ T cell" ; a owl:Class ; rdfs:label "mature Vgamma1.1-positive, Vdelta6.3-positive thymocyte" ; rdfs:subClassOf obo:CL_0002412 . obo:CL_0002417 obo:IAO_0000115 "An immature or mature cell of the first erythroid lineage to arise during embryonic development." ; terms:contributor ; oboInOwl:creation_date "2010-10-12T11:22:41Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "primitive erythroid lineage cell" ; rdfs:subClassOf obo:CL_0000764 . obo:CL_0002418 obo:IAO_0000115 "A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells." ; terms:contributor ; oboInOwl:creation_date "2010-10-12T12:21:16Z"^^xsd:dateTime ; oboInOwl:hasDbXref "MESH:D055018" ; a owl:Class ; rdfs:label "hemangioblast" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000222, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002354 ] . obo:CL_0002419 obo:IAO_0000115 "A T cell that expresses a T cell receptor complex and has completed T cell selection." ; terms:contributor ; oboInOwl:creation_date "2010-10-12T01:56:15Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "CD3e-positive T cell", "mature T-cell" ; oboInOwl:hasRelatedSynonym "CD3epsilon T cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "mature T cell" ; rdfs:subClassOf obo:CL_0000084, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042101 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0045058 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042101 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0045058 ] ) ] . obo:CL_0002420 obo:IAO_0000115 "A T cell that has not completed T cell selection." ; terms:contributor ; oboInOwl:creation_date "2010-10-12T01:56:17Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0001372", "CALOHA:TS-1042" ; oboInOwl:hasExactSynonym "immature T-cell" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:cellxgene_subset ; a owl:Class ; rdfs:label "immature T cell" ; rdfs:subClassOf obo:CL_0000084, [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0045058 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0045058 ] ) ] . obo:CL_0002421 obo:IAO_0000115 "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." ; terms:contributor ; oboInOwl:creation_date "2010-10-15T09:24:05Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "nucleated reticulocyte" ; rdfs:subClassOf obo:CL_0000558, obo:CL_0002242 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000558 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002505 ] ) ] . obo:CL_0002422 obo:IAO_0000115 "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes." ; terms:contributor ; oboInOwl:creation_date "2010-10-15T09:24:08Z"^^xsd:dateTime ; oboInOwl:hasDbXref "CALOHA:TS-0864", "FMA:66785" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "enucleated reticulocyte" ; rdfs:subClassOf obo:CL_0000225, obo:CL_0000558, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005840 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000558 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005840 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001405 ] ) ] . obo:CL_0002423 obo:IAO_0000115 "A DN2 thymocyte that is Kit-hi." ; terms:contributor ; oboInOwl:creation_date "2010-10-21T10:12:05Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Observed in mice. There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'." ; rdfs:label "DN2a thymocyte" ; rdfs:subClassOf obo:CL_0000806, [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002065 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000806 [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002065 ] ) ] . obo:CL_0002424 obo:IAO_0000115 "A DN2 thymocyte that is Kit-low." ; terms:contributor ; oboInOwl:creation_date "2010-10-21T10:12:08Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Observed in mice. There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'." ; rdfs:label "DN2b thymocyte" ; rdfs:subClassOf obo:CL_0000806, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002423 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002065 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000806 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002065 ] ) ] . obo:CL_0002425 obo:IAO_0000115 "A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-10-21T01:16:24Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "ETP", "preT.ETP.Th" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "ETPs are reportedly CD1a-negative, CD4-negative, CD7-positive, CD8a-negative, CD8b-negative, CD33-low, CD34-high, CD38-low, CD45RA-positive, and CD45RO-negative." ; rdfs:label "early T lineage precursor" ; rdfs:subClassOf obo:CL_0000827, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000827 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] ) ] . obo:CL_0002426 obo:IAO_0000115 "A mature natural killer cell that is CD11b-positive and CD27-positive." ; terms:contributor ; oboInOwl:creation_date "2010-10-25T03:07:59Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "A natural killer cell that is NK1.1-positive, CD11b-positive, and CD27-positive." ; rdfs:label "CD11b-positive, CD27-positive natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0002438, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001963 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002438 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001963 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] ) ] . obo:CL_0002427 obo:IAO_0000115 "A double-positive, alpha-beta thymocyte that is small and not proliferating." ; terms:contributor ; oboInOwl:creation_date "2010-10-21T01:59:06Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "T.DP.sm.Th" ; a owl:Class ; rdfs:label "resting double-positive thymocyte" ; rdfs:subClassOf obo:CL_0000809, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000587 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000809 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000587 ] ) ] . obo:CL_0002428 obo:IAO_0000115 "A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating." ; terms:contributor ; oboInOwl:creation_date "2010-10-21T01:59:11Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "T.DPb.Th", "activated double-positive thymocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "double-positive blast" ; rdfs:subClassOf obo:CL_0000809, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000586 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0008283 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002427 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000809 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000586 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0008283 ] ) ] . obo:CL_0002429 obo:IAO_0000115 "A double-positive thymocyte that is CD69-positive and has begun positive selection." ; terms:contributor ; oboInOwl:creation_date "2010-10-21T02:11:52Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "T.DP69+.Th" ; a owl:Class ; rdfs:label "CD69-positive double-positive thymocyte" ; rdfs:subClassOf obo:CL_0000809, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0043368 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002428 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042105 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000809 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0043368 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042105 ] ) ] . obo:CL_0002430 obo:IAO_0000115 "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." ; terms:contributor ; oboInOwl:creation_date "2010-10-21T02:29:19Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "T.4int8+.Th", "T_4int8+_Th" ; a owl:Class ; rdfs:label "CD4-intermediate, CD8-positive double-positive thymocyte" ; rdfs:subClassOf obo:CL_0000809, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0043368 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002429 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001004 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000809 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0043368 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001004 ] ) ] . obo:CL_0002431 obo:IAO_0000115 "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD8 co-receptor." ; terms:contributor ; oboInOwl:creation_date "2010-10-21T02:29:23Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "T.4+8int.Th", "T_4+8int_Th" ; a owl:Class ; rdfs:label "CD4-positive, CD8-intermediate double-positive thymocyte" ; rdfs:subClassOf obo:CL_0000809, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0043368 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002429 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000025402 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000809 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0043368 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000025402 ] ) ] . obo:CL_0002432 obo:IAO_0000115 "A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." ; terms:contributor ; oboInOwl:creation_date "2010-10-21T02:43:52Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "CD24-positive, CD4 single-positive semimature thymocyte", "T.4SP24int.Th" ; a owl:Class ; rdfs:comment "Described in the immgene database as being CD24-intermediate." ; rdfs:label "CD24-positive, CD4 single-positive thymocyte" ; rdfs:subClassOf obo:CL_0000810, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002433 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000810 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] ) ] . obo:CL_0002433 obo:IAO_0000115 "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." ; terms:contributor ; oboInOwl:creation_date "2010-10-21T02:46:02Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "T.4SP69+.Th", "intermediate CD4-single-positive" ; a owl:Class ; rdfs:label "CD69-positive, CD4-positive single-positive thymocyte" ; rdfs:subClassOf obo:CL_0000810, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002431 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000810 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] ) ] . obo:CL_0002434 obo:IAO_0000115 "A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." ; terms:contributor ; oboInOwl:creation_date "2010-10-21T02:59:10Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "CD24-positive, CD8 single-positive semimature thymocyte", "T.8SP24int.Th" ; a owl:Class ; rdfs:comment "Described in the immgene database as being CD24-intermediate." ; rdfs:label "CD24-positive, CD8 single-positive thymocyte" ; rdfs:subClassOf obo:CL_0000811, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002435 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000811 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] ) ] . obo:CL_0002435 obo:IAO_0000115 "A CD8-positive, CD4-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." ; terms:contributor ; oboInOwl:creation_date "2010-10-21T02:59:14Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "T.8SP69+.Th", "intermediate CD8-single-positive" ; a owl:Class ; rdfs:label "CD69-positive, CD8-positive single-positive thymocyte" ; rdfs:subClassOf obo:CL_0000811, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002430 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000811 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] ) ] . obo:CL_0002436 obo:IAO_0000115 "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-10-21T03:31:19Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "T.4SP24-.Th" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "mature CD4 single-positive thymocyte" ; rdfs:subClassOf obo:CL_0000624, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002432 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0002437 obo:IAO_0000115 "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-10-21T03:51:50Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "T.8SP24-.Th" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "mature CD8 single-positive thymocyte" ; rdfs:subClassOf obo:CL_0000625, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002434 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000625 [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0002438 obo:IAO_0000115 "A mature NK cell that is NK1.1-positive." ; terms:contributor ; oboInOwl:creation_date "2010-10-25T03:18:04Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "NK.sp", "NK1.1-positive NK cell" ; a owl:Class ; rdfs:comment "Note: Nk1.1 expression is restricted to C57BL strains of laboratory mice." ; rdfs:label "NK1.1-positive natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0000824, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002977 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000824 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002977 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] ) ] . obo:CL_0002439 obo:IAO_0000115 "A NK1.1-positive T cell that is NKGA2-positive." ; terms:contributor ; oboInOwl:creation_date "2010-10-25T03:31:09Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "NK.G2A+.SP" ; a owl:Class ; rdfs:label "NKGA2-positive natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0002438, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002023 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002438 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002023 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] ) ] . obo:CL_0002440 obo:IAO_0000115 "A NK1.1-positive T cell that is Ly49D-positive." ; terms:contributor ; oboInOwl:creation_date "2010-10-25T03:36:19Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "NK.49D+.Sp" ; a owl:Class ; rdfs:label "Ly49D-positive natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0002438, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009619 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002438 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009619 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] ) ] . obo:CL_0002441 obo:IAO_0000115 "A NK1.1-positive T cell that is CD94-positive." ; terms:contributor ; oboInOwl:creation_date "2010-10-25T03:36:28Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "NK.94+.Sp" ; a owl:Class ; rdfs:label "CD94-positive natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0002438, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001402 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002438 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] ) ] . obo:CL_0002442 obo:IAO_0000115 "A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative." ; terms:contributor ; oboInOwl:creation_date "2010-10-25T03:56:21Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "CD94- Ly49I-negative NK cell", "NK.49Cl-94-.Sp" ; a owl:Class ; rdfs:label "CD94-negative, Ly49CI-negative natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0000623, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001402 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000009618 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000623 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001402 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000009618 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] ) ] . obo:CL_0002443 obo:IAO_0000115 "A NK1.1-positive T cell that is Ly49Cl-positive." ; terms:contributor ; oboInOwl:creation_date "2010-10-25T03:36:38Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Ly49I-positive NK cell", "NK.49Cl+.Sp" ; a owl:Class ; rdfs:label "Ly49CI-positive natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0002438, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009618 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002438 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009618 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] ) ] . obo:CL_0002444 obo:IAO_0000115 "A NK1.1-positive T cell that is Ly49H-positive." ; terms:contributor ; oboInOwl:creation_date "2010-10-25T03:36:43Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "LyH49H-positive" ; a owl:Class ; rdfs:label "Ly49H-positive natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0002438, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009623 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002438 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] ) ] . obo:CL_0002445 obo:IAO_0000115 "A NK1.1-positive T cell that is Ly49D-negative." ; terms:contributor ; oboInOwl:creation_date "2010-10-25T03:39:02Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "NK.49D-.Sp" ; a owl:Class ; rdfs:label "Ly49D-negative natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0002438, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000009619 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002438 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000009619 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] ) ] . obo:CL_0002446 obo:IAO_0000115 "A NK1.1-positive T cell that is Ly49Cl-negative." ; terms:contributor ; oboInOwl:creation_date "2010-10-25T03:52:04Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Ly49I-negative NK cell", "NK.49Cl-.Sp" ; a owl:Class ; rdfs:label "Ly49CI-negative natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0002438, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000009618 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002438 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000009618 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] ) ] . obo:CL_0002447 obo:IAO_0000115 "A NK1.1-positive T cell that is CD94-negative." ; terms:contributor ; oboInOwl:creation_date "2010-10-25T03:54:18Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "NK.94-.Sp" ; a owl:Class ; rdfs:label "CD94-negative natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0002438, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001402 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002438 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] ) ] . obo:CL_0002448 obo:IAO_0000115 "A NK1.1-positive T cell that is Ly49H-negative." ; terms:contributor ; oboInOwl:creation_date "2010-10-25T03:42:42Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "LyH49H-negative" ; a owl:Class ; rdfs:label "Ly49H-negative natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0002438, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000009623 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid11008 ] . obo:CL_0002449 obo:IAO_0000115 "A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive." ; terms:contributor ; oboInOwl:creation_date "2010-10-25T03:56:27Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "NK.49Cl+94+.Sp" ; a owl:Class ; rdfs:label "CD94-positive Ly49CI-positive natural killer cell, mouse" ; rdfs:subClassOf obo:CL_0002441, obo:CL_0002443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002438 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009618 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] ) ] . obo:CL_0002450 obo:IAO_0000115 "A specialized hair cell that has an elongated kinocilium upon which an otolith accretes. The tether cell then anchors the otolith in place." ; terms:contributor ; oboInOwl:creation_date "2010-11-10T01:41:00Z"^^xsd:dateTime ; oboInOwl:hasDbXref "ZFA:0005565" ; a owl:Class ; rdfs:label "tether cell" ; rdfs:subClassOf obo:CL_0002374 . obo:CL_0002451 obo:IAO_0000115 "A multi-fate stem cell that is the source of cells for growth of the mammary gland during puberty and gestation. This cell type gives rise to both the luminal and myoepithelial cell types of the gland, and have been shown to have the ability to regenerate the entire organ in mice. This cell type also plays an important role in carcinogenesis of the breast. This cell type is Lin-, CD24-positive, CD29-hi." ; terms:contributor ; oboInOwl:creation_date "2010-11-10T01:46:51Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "mammary stem cell" ; rdfs:subClassOf obo:CL_0000048 . obo:CL_0002452 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000134 ; a owl:Class ; owl:deprecated true . obo:CL_0002453 obo:IAO_0000115 "A proliferative and migratory glial progenitor cell that derives from a neural stem cell and resides within the central nervous system. It possesses the capacity to differentiate into a committed oligodendrocyte progenitor (COP) through a well-defined series of maturation steps, ultimately giving rise to a myelinating oligodendrocyte (MOL). In mice and humans, it is characterized by the expression of specific molecular markers, including Pdgfra, Cspg4 (also known as NG2) and Olig2." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description "This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991)." ; oboInOwl:creation_date "2010-11-10T02:51:34Z"^^xsd:dateTime ; oboInOwl:hasDbXref "MESH:D000073637" ; oboInOwl:hasRelatedSynonym "NG2 cell", "O2-A", "OPC", "Polydendrocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "oligodendrocyte precursor cell" ; rdfs:subClassOf obo:CL_0000123, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000125 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000047 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000339 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_4023059 ] . obo:CL_0002454 obo:IAO_0000115 "CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8-alpha-negative and is CD205-positive." ; terms:contributor ; oboInOwl:creation_date "2010-11-22T01:10:28Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "DC.8-4-11b+", "spleen double-negative dendritic cell" ; a owl:Class ; rdfs:label "CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell" ; rdfs:subClassOf obo:CL_0002465, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002465 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] ) ] . obo:CL_0002455 obo:IAO_0000115 "A CD11c-low plasmacytoid dendritic cell that is CD8-alpha-negative and CD4-positive." ; terms:contributor ; oboInOwl:creation_date "2010-11-22T01:27:37Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "DC.pDC.8-" ; a owl:Class ; rdfs:label "CD8-alpha-negative plasmacytoid dendritic cell" ; rdfs:subClassOf obo:CL_0000989, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000989 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] ) ] . obo:CL_0002456 obo:IAO_0000115 "A CD11c-low plasmacytoid dendritic cell that is CD8-alpha-positive and CD4-positive." ; terms:contributor ; oboInOwl:creation_date "2010-11-22T01:23:07Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "DC.pDC.8+" ; a owl:Class ; rdfs:label "CD8-alpha-positive plasmacytoid dendritic cell" ; rdfs:subClassOf obo:CL_0000989, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001084 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000989 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001084 ] ) ] . obo:CL_0002457 obo:IAO_0000115 "A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-11-22T03:57:57Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "epidermal Langerhans cell" ; rdfs:subClassOf obo:CL_0000453, obo:CL_0002465, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000453 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-epidermal-ridge/v1.2/assets/2d-ftu-skin-epidermal-ridge.png" . obo:CL_0002458 obo:IAO_0000115 "A dermal dendritic cell that is langerin-positive and CD103-positive." ; terms:contributor ; oboInOwl:creation_date "2010-11-22T04:06:22Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "langerin-positive dermal dendritic cell" ; rdfs:subClassOf obo:CL_0001006, obo:CL_0002461 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001006 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001010 ] ) ] . obo:CL_0002459 obo:IAO_0000115 "A dermal dendritic cell that is langerin-negative, CD103-negative, and CD11b-positive." ; terms:contributor ; oboInOwl:creation_date "2010-11-22T04:09:44Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "langerin-negative dermal dendritic cell" ; rdfs:subClassOf obo:CL_0001006, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001010 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001006 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001010 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] ) ] . obo:CL_0002460 obo:IAO_0000115 "A conventional thymic dendritic cell that is CD8-alpha-negative." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-11-23T10:58:53Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "DC.8-.Th" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "CD8-alpha-negative thymic conventional dendritic cell" ; rdfs:subClassOf obo:CL_0000941, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000941 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] ) ] . obo:CL_0002461 obo:IAO_0000115 "A conventional dendritic cell that is CD103-positive. This cell type is usually found in non-lymphoid tissue." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T01:32:43Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "CD103-positive dendritic cell" ; rdfs:subClassOf obo:CL_0000766, obo:CL_0000990, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001010 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002010 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001010 ] ) ] . obo:CL_0002462 obo:IAO_0000115 "A F4/80-negative dendritic cell located in adipose tissue." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T01:38:21Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "adipose dendritic cell" ; rdfs:subClassOf obo:CL_0000766, obo:CL_0000990, obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001013 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001813 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002010 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001013 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001813 ] ) ] . obo:CL_0002463 obo:IAO_0000115 "An adipose dendritic cell that is SIRPa-positive." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T01:40:44Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "DC.SIRPa+.Ad" ; a owl:Class ; rdfs:label "SIRPa-positive adipose dendritic cell" ; rdfs:subClassOf obo:CL_0002462, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001968 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001968 ] ) ] . obo:CL_0002464 obo:IAO_0000115 "An adipose dendritic cell that is SIRPa-negative." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T01:40:46Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "DC.SIRPa-.Ad" ; a owl:Class ; rdfs:label "SIRPa-negative adipose dendritic cell" ; rdfs:subClassOf obo:CL_0002462, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001968 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001968 ] ) ] . obo:CL_0002465 obo:IAO_0000115 "A conventional dendritic cell that expresses CD11b (ITGAM)." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T01:50:05Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "CD11b-positive dendritic cell" ; rdfs:subClassOf obo:CL_0000990, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] ) ] . obo:CL_0002466 obo:IAO_0000115 "A CD11b-positive dendritic cell located in the serosal portion of the small intestine epithelium. This cell type is CD45-positive, MHC-II-positive, CD11c-low, CD103-negative." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T02:00:21Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "DC.11cloSer.SI" ; a owl:Class ; rdfs:label "small intestine serosal dendritic cell" ; rdfs:subClassOf obo:CL_0002465, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001010 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001013 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002465 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001010 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001013 ] ) ] ; foaf:depiction . obo:CL_0002467 obo:IAO_0000115 "A myeloid suppressor cell that is Gr1-high and CD11c-negative." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T02:15:12Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "MDS.Gr1hi" ; a owl:Class ; rdfs:label "Gr1-high myeloid suppressor cell" ; rdfs:subClassOf obo:CL_0000889, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001013 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002980 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000889 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002980 ] ) ] . obo:CL_0002468 obo:IAO_0000115 "A myeloid suppressor cell that is Gr1-low and CD11c-positive." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T02:19:43Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "MDS.Gr1lo" ; a owl:Class ; rdfs:label "Gr1-low myeloid suppressor cell" ; rdfs:subClassOf obo:CL_0000889, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001013 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002980 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000889 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002980 ] ) ] . obo:CL_0002469 obo:IAO_0000115 "Gr1-high monocyte that lacks MHC-II receptor complex." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T03:27:12Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Mo.6C+II-" ; a owl:Class ; rdfs:label "MHC-II-negative classical monocyte" ; rdfs:subClassOf obo:CL_0002395, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042613 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002395 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042613 ] ) ] . obo:CL_0002470 obo:IAO_0000115 "Gr1-high monocyte that has a MHC-II receptor complex." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T03:30:21Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Mo.6c+II" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "MHC-II-positive classical monocyte" ; rdfs:subClassOf obo:CL_0002395, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002395 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ] ) ] . obo:CL_0002471 obo:IAO_0000115 "Gr1-low non-classical monocyte that lacks expression of a MHC-II complex." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T03:38:15Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Mo.6C-II-" ; a owl:Class ; rdfs:label "MHC-II-negative non-classical monocyte" ; rdfs:subClassOf obo:CL_0002058, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042613 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002058 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042613 ] ) ] . obo:CL_0002472 obo:IAO_0000115 "Gr1-low non-classical monocyte that has low to intermediate expression of the MHC-II complex." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T03:47:53Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Mo.6C-IIint" ; a owl:Class ; rdfs:label "MHC-II-low non-classical monocyte" ; rdfs:subClassOf obo:CL_0002058, [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042613 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002058 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042613 ] ) ] . obo:CL_0002473 obo:IAO_0000115 "Gr1-low non-classical monocyte that has high surface expression of a MHC-II complex." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T03:47:55Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Mo.6C-II+" ; a owl:Class ; rdfs:label "MHC-II-high non-classical monocyte" ; rdfs:subClassOf obo:CL_0002058, [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002058 [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ] ) ] . obo:CL_0002474 obo:IAO_0000115 "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T04:00:52Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "lymphoid MHC-II-negative classical monocyte" ; rdfs:subClassOf obo:CL_0002469, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001013 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002469 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001012 ] ) ] . obo:CL_0002475 obo:IAO_0000115 "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-intermediate, and CD11b-high." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T04:09:09Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "lymphoid MHC-II-negative non-classical monocyte" ; rdfs:subClassOf obo:CL_0002471, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001013 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002471 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001012 ] ) ] . obo:CL_0002476 obo:IAO_0000115 "A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T04:19:25Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004732" ; oboInOwl:hasRelatedSynonym "MF.BM" ; a owl:Class ; rdfs:label "bone marrow macrophage" ; rdfs:subClassOf obo:CL_0000864, obo:CL_0010004, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001014 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002980 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000864 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002980 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ] ) ] . obo:CL_0002477 obo:IAO_0000115 "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T04:31:28Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "adipose macrophage" ; rdfs:subClassOf obo:CL_0000864, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001013 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001968 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000864 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001968 ] ) ] . obo:CL_0002478 obo:IAO_0000115 "An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T04:40:50Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "MF.Autofl.Ad" ; a owl:Class ; rdfs:label "F4/80-negative adipose macrophage" ; rdfs:subClassOf obo:CL_0002477, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001813 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002477 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ] ) ] . obo:CL_0002479 obo:IAO_0000115 "An adipose macrophage that does not express MHC-II but is F4/80-positive." ; terms:contributor ; oboInOwl:creation_date "2010-11-23T04:35:53Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "MF.F480+.Ad" ; a owl:Class ; rdfs:label "F4/80-positive adipose macrophage" ; rdfs:subClassOf obo:CL_0002477, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002477 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ] ) ] . obo:CL_0002480 obo:IAO_0000115 "A goblet cell located in the nasal epithelium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-12-03T03:03:02Z"^^xsd:dateTime ; oboInOwl:hasDbXref "MP:0002262" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "The marker set LYPD2, MUC5AC can identify the Human cell type nasal mucosa goblet cell in the lung with a confidence of 0.81 (NS-Forest FBeta value)." ; rdfs:label "nasal mucosa goblet cell" ; rdfs:subClassOf obo:CL_0002370, obo:CL_0002631, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005384 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000027 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001826 ] ) ] . obo:CL_0002481 obo:IAO_0000115 "The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule." ; terms:contributor ; oboInOwl:creation_date "2010-12-03T03:11:48Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "peritubular myoid cell" ; rdfs:subClassOf obo:CL_0000185, obo:CL_0002625 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000185 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001343 ] ) ] . obo:CL_0002482 obo:IAO_0000115 "A melanocyte that produces pigment in the dermis." ; terms:contributor ; oboInOwl:creation_date "2010-12-03T03:17:05Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "dermal melanocyte" ; rdfs:subClassOf obo:CL_1000458, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] ) ] . obo:CL_0002483 obo:IAO_0000115 "A melanocyte that produces pigment within the hair follicle." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2010-12-03T03:17:09Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "hair follicle melanocyte" ; rdfs:subClassOf obo:CL_0002559, obo:CL_2000000 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002073 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-hair-follicle/v1.0/assets/2d-ftu-skin-hair-follicle.png" . obo:CL_0002484 obo:IAO_0000115 "A melanocyte that produces pigment in the epithelium." ; terms:contributor ; oboInOwl:creation_date "2010-12-03T03:17:14Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "The text defintion reference to the MP term appears to reference an epidermal melanocyte term. This term represents any melanocyte in any epithelium." ; rdfs:label "epithelial melanocyte" ; rdfs:subClassOf obo:CL_0000148, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000483 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000483 ] ) ] . obo:CL_0002485 obo:IAO_0000115 "A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium." ; terms:contributor ; oboInOwl:creation_date "2010-12-03T03:25:32Z"^^xsd:dateTime ; oboInOwl:inSubset cl:eye_upper_slim ; a owl:Class ; rdfs:label "retinal melanocyte" ; rdfs:subClassOf obo:CL_0000148, obo:CL_0009004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] . obo:CL_0002486 obo:IAO_0000115 "A melanocyte located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) ." ; terms:contributor ; oboInOwl:creation_date "2010-12-03T03:29:15Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "strial intermediate cell" ; rdfs:subClassOf obo:CL_0000710, obo:CL_0002484, obo:CL_0002491, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002282 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002282 ] ) ] . obo:CL_0002487 obo:IAO_0000115 "A neuronal receptor that respond to mechanical pressure or distortion in the skin." ; terms:contributor ; oboInOwl:creation_date "2010-12-06T02:53:30Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "cutaneous/subcutaneous mechanoreceptor cell" ; rdfs:subClassOf obo:CL_0000199 . obo:CL_0002488 obo:IAO_0000115 "A trophoblast cell that has a large volume of cytoplasm, is polyploid and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta." ; terms:contributor ; oboInOwl:creation_date "2010-12-06T02:55:24Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "giant trophoblast cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "trophoblast giant cell" ; rdfs:subClassOf obo:CL_0000351, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000586 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001974 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000351 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000586 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001974 ] ) ] . obo:CL_0002489 obo:IAO_0000115 "A thymocyte that lacks expression of CD4 and CD8." ; terms:contributor ; oboInOwl:creation_date "2010-12-06T03:03:38Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "CD4-CD8- T cell", "double negative T cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "These are precursors to mature T cells; normally, they do not circulate, but are found in the thymus and they have not undergone rearrangement of the alpha and beta T cell receptor genes." ; rdfs:label "double negative thymocyte" ; rdfs:subClassOf obo:CL_0000893, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025402 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000893 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025402 ] ) ] . obo:CL_0002490 obo:IAO_0000115 "A supporting cell of the organ of Corti." ; terms:contributor ; oboInOwl:creation_date "2010-12-06T03:09:01Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "organ of Corti supporting cell" ; rdfs:subClassOf obo:CL_0002315, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002227 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002227 ] ) ] . obo:CL_0002491 obo:IAO_0000115 "A specialized cell involved in auditory sensory perception." ; terms:contributor ; oboInOwl:creation_date "2010-12-06T03:18:43Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "auditory epithelial cell" ; rdfs:subClassOf obo:CL_0000098, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050910 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050910 ] ) ] . obo:CL_0002492 obo:IAO_0000115 "A polarized columnar cell that covesr the lateral surface of the cochlear duct, secretes potassium ions and forms a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria." ; terms:contributor ; oboInOwl:creation_date "2010-12-06T03:20:41Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "strial marginal cell" ; rdfs:subClassOf obo:CL_0002491 . obo:CL_0002493 obo:IAO_0000115 "A polarized cell that is juxtaposed to fibrocytes in the underlying spiral ligament. This cell type secretes potassium ions derived from fibrocytes through gap junctions." ; terms:contributor ; oboInOwl:creation_date "2010-12-06T03:26:53Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Basal cells form a multi-layered epithelial barrier that separates the extracellular spaces of the stria vascularis and the spiral ligament[PMID:18353863]" ; rdfs:label "strial basal cell" ; rdfs:subClassOf obo:CL_0002491, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002282 ] . obo:CL_0002494 obo:IAO_0000115 "A cell located in the heart, including both muscle and non muscle cells." ; terms:contributor ; oboInOwl:creation_date "2010-12-07T09:37:22Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0001539", "CALOHA:TS-0115", "FMA:83808", "FMA:84791" ; oboInOwl:hasExactSynonym "heart cell" ; a owl:Class ; rdfs:comment "From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart." ; rdfs:label "cardiocyte" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007100 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007100 ] ) ] ; skos:prefLabel "cardiocyte" . obo:CL_0002495 obo:IAO_0000115 "A fetal and neonatal heart cell that undergoes proliferation and is not yet terminally differentiated into a binucleate or a multinucleate cardiac myocyte." ; terms:contributor ; oboInOwl:creation_date "2010-12-07T09:50:41Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "embryonic cardiomyocyte", "neonatal cardiomyocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "fetal cardiomyocyte" ; rdfs:subClassOf obo:CL_0000746 . obo:CL_0002496 obo:IAO_0000115 "A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response." ; terms:contributor ; oboInOwl:creation_date "2010-12-07T09:54:50Z"^^xsd:dateTime ; oboInOwl:hasDbXref "MESH:D000075942" ; oboInOwl:hasExactSynonym "IEL", "intraepithelial T cell", "intraepithelial T-cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "intraepithelial lymphocyte" ; rdfs:subClassOf obo:CL_0002419, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001277 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002385 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002419 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001277 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002385 ] ) ] . obo:CL_0002497 obo:IAO_0000115 "A trophoblast giant cell derived from the mural trophectoderm." ; terms:contributor ; oboInOwl:creation_date "2010-12-07T10:07:47Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EMAPA:16066" ; a owl:Class ; rdfs:label "primary trophoblast giant cell" ; rdfs:subClassOf obo:CL_0002488 . obo:CL_0002498 obo:IAO_0000115 "A trophoblast giant cell that is derived from ectoplacental cone and, later in gestation, the spongiotrophoblast." ; terms:contributor ; oboInOwl:creation_date "2010-12-07T10:07:52Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "secondary trophoblast giant cell" ; rdfs:subClassOf obo:CL_0002488 . obo:CL_0002499 obo:IAO_0000115 "A trophoblast cell that arises in the junctional zone (basal plate) of the placenta." ; terms:contributor ; oboInOwl:creation_date "2010-12-07T12:56:56Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "spongiotrophoblast" ; a owl:Class ; rdfs:label "spongiotrophoblast cell" ; rdfs:subClassOf obo:CL_0000351, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004021 ] . obo:CL_0002500 obo:IAO_0000115 "A P/D1 enteroendocrine cell that is Grimelius positive and stores bombesin-like polypeptide." ; terms:contributor ; oboInOwl:creation_date "2010-12-07T03:42:06Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "P enteroendocrine cell" ; rdfs:subClassOf obo:CL_0002268 . obo:CL_0002501 obo:IAO_0000115 "A P/D1 enteroendocrine cell that is argyrophilic and stores vasoactive intestinal polypeptide." ; terms:contributor ; oboInOwl:creation_date "2010-12-07T03:42:09Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:63207" ; a owl:Class ; rdfs:label "type D1 enteroendocrine cell" ; rdfs:subClassOf obo:CL_0002268 . obo:CL_0002502 obo:IAO_0000115 "An enteroendocrine cell of the small intestine that secretes motilin." ; terms:contributor ; oboInOwl:creation_date "2010-12-07T03:55:49Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "Mo enteroendocrine cell" ; oboInOwl:hasDbXref "FMA:63420" ; a owl:Class ; rdfs:label "type M enteroendocrine cell" ; rdfs:subClassOf obo:CL_0002272, obo:CL_0009006 . obo:CL_0002503 obo:IAO_0000115 "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" ; terms:contributor ; oboInOwl:creation_date "2010-12-07T04:03:56Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0002441", "FMA:84639" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "adventitial cell" ; rdfs:subClassOf obo:CL_0000630, obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005742 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002320 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005742 ] ) ] . obo:CL_0002504 obo:IAO_0000115 "A smooth muscle cell of the intestine." ; terms:contributor ; terms:description """Enteric smooth muscle cells are a specialized type of cell found in the gastrointestinal tract. They are an integral part of the enteric nervous system, which regulates the functions of the gastrointestinal system. These cells have a unique structural organization that enables their primary function: the contraction and relaxation necessary for the propulsion of gastrointestinal contents. Smooth muscle cells in the enteric system possess unique attributes that distinguish them from other smooth muscle cells in the body. One crucial function is peristalsis, where these cells contract in a coordinated manner, generating a wave of contraction and relaxation. This peristaltic movement facilitates the movement of food particles through the digestive tract, playing a vital role in the digestion and absorption processes in animals. Additionally, these cells are responsible for maintaining the tone of gastrointestinal sphincters, controlling passage and preventing one-sided movement of the contents. Enteric smooth muscle cells are also involved in local immune responses of the gastrointestinal tract. They can communicate with local immune cells and secrete cytokines or other signaling molecules in response to infectious organisms, which makes them crucial mediocellular players in gastrointestinal homeostasis and response to disease. Their interactions with other cell types, such as neurons, myofibroblasts, and interstitial cells of Cajal, further contribute to these cells' role in maintaining the physiological functions of the gastrointestinal system. Overall, enteric smooth muscle cells provide an indispensable contribution to the complex operations of the digestive tract. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2011-01-17T03:39:38Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "intestinal smooth muscle cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "enteric smooth muscle cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002504" ; rdfs:subClassOf obo:CL_0000192, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] . obo:CL_0002505 obo:IAO_0000115 "A CD11b-positive dendritic cell that is CD11b-high, CD45-positive, MHC-II-positive and CD103-negative." ; terms:contributor ; oboInOwl:creation_date "2011-01-21T01:27:41Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "DC.103-11b+.Lv" ; a owl:Class ; rdfs:label "liver CD103-negative dendritic cell" ; rdfs:subClassOf obo:CL_0002454, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001010 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001281 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002454 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001010 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001281 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001012 ] ) ] . obo:CL_0002506 obo:IAO_0000115 "A CD11b-positive dendritic cell that is CD11b-low, CD45-positive, MHC-II-high and CD103-positive that is located in the liver." ; terms:contributor ; oboInOwl:creation_date "2011-01-21T01:27:45Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "DC.103+11b-.Lv" ; a owl:Class ; rdfs:label "liver CD103-positive dendritic cell" ; rdfs:subClassOf obo:CL_0002454, obo:CL_0002461, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001281 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002454 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001281 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001010 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ] ) ] . obo:CL_0002507 obo:IAO_0000115 "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative." ; terms:contributor ; oboInOwl:creation_date "2011-01-21T01:57:00Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "langerin-positive lymph node dendritic cell" ; rdfs:subClassOf obo:CL_0000990, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001293 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001293 ] ) ] . obo:CL_0002508 obo:IAO_0000115 "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-negative, MHC-II-positive, and CD4-negative and CD8a-negative." ; terms:contributor ; oboInOwl:creation_date "2011-01-21T02:13:58Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "langerin-negative, CD103-negative lymph node dendritic cell" ; rdfs:subClassOf obo:CL_0000990, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001010 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001293 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001010 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001293 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ] ) ] . obo:CL_0002509 obo:IAO_0000115 "A langerin-positive lymph node dendritic cell that is CD103-positive and CD11b-low." ; terms:contributor ; oboInOwl:creation_date "2011-01-21T02:07:54Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "CD103-positive, langerin-positive lymph node dendritic cell" ; rdfs:subClassOf obo:CL_0002454, obo:CL_0002461, obo:CL_0002507, [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002507 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001010 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ] ) ] . obo:CL_0002510 obo:IAO_0000115 "A langerin-positive lymph node dendritic cell that is CD103-negative and CD11b-high." ; terms:contributor ; oboInOwl:creation_date "2011-01-21T02:11:14Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "CD103-negative, langerin-positive lymph node dendritic cell" ; rdfs:subClassOf obo:CL_0002454, obo:CL_0002507, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001010 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002507 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001010 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001012 ] ) ] . obo:CL_0002511 obo:IAO_0000115 "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-low." ; terms:contributor ; oboInOwl:creation_date "2011-01-21T02:22:15Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "CD11b-low, CD103-negative, langerin-negative lymph node dendritic cell" ; rdfs:subClassOf obo:CL_0002454, obo:CL_0002508, [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002508 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001012 ] ) ] . obo:CL_0002512 obo:IAO_0000115 "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-high." ; terms:contributor ; oboInOwl:creation_date "2011-01-21T02:16:21Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "CD11b-high, CD103-negative, langerin-negative lymph node dendritic cell" ; rdfs:subClassOf obo:CL_0002454, obo:CL_0002508, [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002508 [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001012 ] ) ] . obo:CL_0002513 obo:IAO_0000115 "A CD8-alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment." ; terms:contributor ; oboInOwl:creation_date "2011-01-24T10:22:18Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "tgd.vg5+.IEL" ; a owl:Class ; rdfs:label "Vgamma5-positive CD8-alpha alpha positive gamma-delta intraepithelial T cell" ; rdfs:subClassOf obo:CL_0000802 . obo:CL_0002514 obo:IAO_0000115 "A CD8-alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment." ; terms:contributor ; oboInOwl:creation_date "2011-01-24T10:25:44Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "tgd.vg5-.IEL" ; a owl:Class ; rdfs:label "Vgamma5-negative CD8-alpha alpha positive gamma-delta intraepithelial T cell" ; rdfs:subClassOf obo:CL_0000802 . obo:CL_0002515 obo:IAO_0000115 "An interrenal chromaffin cell found in teleosts that contain heterogeneous vesicles with electron-dense granules located asymmetrically within the vesicular membrane." ; terms:contributor ; oboInOwl:creation_date "2011-02-08T10:11:55Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "interrenal noradrenaline type cell", "type n interrenal cell" ; a owl:Class ; rdfs:label "interrenal norepinephrine type cell" ; rdfs:subClassOf obo:CL_0000459, obo:CL_0002516 . obo:CL_0002516 obo:IAO_0000115 "A chromaffin cell interspersed among the interrenal epithelial layer of the anterior kidney of teloest fish." ; terms:contributor ; oboInOwl:creation_date "2011-02-08T10:21:35Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "interrenal chromaffin cell" ; rdfs:subClassOf obo:CL_0000166 . obo:CL_0002517 obo:IAO_0000115 "An interrenal chromaffin cell found in teleosts that contain small, homogeneous electron-lucent granules that are separated from the vesicular membrane by a visible halo." ; terms:contributor ; oboInOwl:creation_date "2011-02-08T10:27:05Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "type a interrenal cell" ; oboInOwl:hasRelatedSynonym "interrenal adrenaline secreting cell" ; a owl:Class ; rdfs:label "interrenal epinephrin secreting cell" ; rdfs:subClassOf obo:CL_0000454, obo:CL_0002516 . obo:CL_0002518 obo:IAO_0000115 "An epithelial cell of the kidney." ; terms:contributor ; oboInOwl:creation_date "2011-02-08T10:46:34Z"^^xsd:dateTime ; oboInOwl:hasDbXref "KUPO:0001019", "ZFA:0009374" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "kidney epithelial cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_1000497 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:CL_0002519 obo:IAO_0000115 "An interrenal epithelial kidney cell is an epithelial cell found in the anterior kidney of teleosts fish. This cell type is arranged in layers around the posterior cardinal vein and contains many mitochondria with tubulovesicular cristae. Interrenal chromaffin cells are interspersed among the tissue layer created by this cell type." ; terms:contributor ; oboInOwl:creation_date "2011-02-08T11:03:32Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "interrenal epithelial cell" ; rdfs:subClassOf obo:CL_0002518 . obo:CL_0002520 obo:IAO_0000115 "An insect excretory cell that regulates hemolymph composition by filtration and filtrate endocytosis." ; terms:contributor ; oboInOwl:creation_date "2011-02-08T01:34:56Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004597" ; a owl:Class ; rdfs:label "nephrocyte" ; rdfs:subClassOf obo:CL_0002522, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_50557 ] . obo:CL_0002521 obo:IAO_0000115 "An adipocyte that is part of subcutaneous adipose tissue." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-02-21T02:51:22Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "subcutaneous fat cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "subcutaneous adipocyte" ; rdfs:subClassOf obo:CL_0000136, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002190 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000136 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002190 ] ) ] . obo:CL_0002522 obo:IAO_0000115 "A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both." ; terms:contributor ; oboInOwl:creation_date "2011-02-08T01:37:59Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "renal filtration cell" ; rdfs:subClassOf obo:CL_0000255, obo:CL_0000424, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001008 ] . obo:CL_0002523 obo:IAO_0000115 "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros." ; terms:contributor , ; oboInOwl:creation_date "2011-02-08T01:58:30Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "mesonephric glomerular visceral epithelial cell" ; a owl:Class ; rdfs:label "mesonephric podocyte" ; rdfs:subClassOf obo:CL_0000653, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000653 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ) ] . obo:CL_0002524 obo:IAO_0000115 "A disseminated nephrocyte is a nephrocyte that filters hemolymph and is found at scattered locations in the fat body or other tissues." ; terms:contributor ; oboInOwl:creation_date "2011-02-08T02:07:33Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "disseminated nephrocyte" ; rdfs:subClassOf obo:CL_0002520 . obo:CL_0002525 obo:IAO_0000115 "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." ; terms:contributor ; oboInOwl:creation_date "2011-02-08T02:02:13Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "metanephric glomerular visceral epithelial cell" ; a owl:Class ; rdfs:label "metanephric podocyte" ; rdfs:subClassOf obo:CL_0000653, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000653 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:CL_0002526 obo:IAO_0000115 "A dermal dendritic cell that is CD1a-negative and CD14-positive." ; oboInOwl:hasExactSynonym "CD14+ dermal DC" ; a owl:Class ; rdfs:comment "They are also CD11c-positive, CD40-positive, CD85j-positive (ILT-2), CD163-positive, CD205-positive (DEC205), CD207-negative (langerin), CD209-positive (DC-SIGN), CD274-positive (PD-L1), CD324-negative (E-cadherin), Factor XIIIa-positive, LOX-I-positive, CLEC6-positive, Dectin-1-positive, and DCIR-positive. Upon stimulation, these cells are capable of producing IL1-beta, IL6, IL8, IL10, IL12p40, IL19, IL20, IL24, TGF-beta, TNF-alpha, GM-CSF, and MCP1. They reside in the dermis." ; rdfs:label "CD14-positive dermal dendritic cell" ; rdfs:subClassOf obo:CL_0001006, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002025 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001889 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045191 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001006 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002025 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045191 ] ) ] . obo:CL_0002527 obo:IAO_0000115 "An immature CD14-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." ; a owl:Class ; rdfs:label "immature CD14-positive dermal dendritic cell" ; rdfs:subClassOf obo:CL_0001009, obo:CL_0002526 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002526 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0002528 obo:IAO_0000115 "A mature CD14-positive dermal dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." ; a owl:Class ; rdfs:label "mature CD14-positive dermal dendritic cell" ; rdfs:subClassOf obo:CL_0001010, obo:CL_0002526, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002527 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002526 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0002529 obo:IAO_0000115 "A dermal dendritic cell that is CD1a-positive and CD14-negative." ; oboInOwl:hasExactSynonym "CD1a+ dermal DC" ; a owl:Class ; rdfs:comment "Reside in the dermis. They are also CD11c-positive, CD40-positive, CD207-negative (langerin), CD209-negative (DC-SIGN), and CD324-negative (E-cadherin). When activated, they are capable of producing CXCL8 (IL-8) and IL-15. Possibly a precursor of Langerhans cells or equivalent of langerin-positive dermal DCs in the mouse." ; rdfs:label "CD1a-positive dermal dendritic cell" ; rdfs:subClassOf obo:CL_0001006, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002025 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001006 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002025 ] ) ] . obo:CL_0002530 obo:IAO_0000115 "An immature CD1a-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." ; a owl:Class ; rdfs:label "immature CD1a-positive dermal dendritic cell" ; rdfs:subClassOf obo:CL_0001009, obo:CL_0002529 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002529 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0002531 obo:IAO_0000115 "A mature CD1a-positive dermal dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." ; a owl:Class ; rdfs:label "mature CD1a-positive dermal dendritic cell" ; rdfs:subClassOf obo:CL_0001010, obo:CL_0002529, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002530 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002529 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0002532 obo:IAO_0000115 "A myeloid dendritic cell found in the blood that is CD16-positive." ; oboInOwl:hasExactSynonym "CD16+ mDC", "CD16-mDC" ; a owl:Class ; rdfs:comment "Normally represent 65-75% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), CD289-positive (TLR9), and CD290-positive (TLR10) by RT-PCR [PMID:17332250]. Upon TLR stimulation, these cells are potent producers of TNF-alpha, while producing little CXCL8 (IL8)." ; rdfs:label "CD16-positive myeloid dendritic cell" ; rdfs:subClassOf obo:CL_0000782, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032640 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000782 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032640 ] ) ] . obo:CL_0002533 obo:IAO_0000115 "An immature CD16-positive myeloid dendritic cell is CD80-low, CD86-low, and MHCII-low." ; a owl:Class ; rdfs:label "immature CD16-positive myeloid dendritic cell" ; rdfs:subClassOf obo:CL_0000840, obo:CL_0002532 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002532 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0002534 obo:IAO_0000115 "A mature CD16-positive myeloid dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." ; a owl:Class ; rdfs:label "mature CD16-positive myeloid dendritic cell" ; rdfs:subClassOf obo:CL_0000841, obo:CL_0002532, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002533 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002532 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001438 ] ) ] . obo:CL_0002535 obo:IAO_0000115 "An epithelial cell of the cervix." ; terms:contributor ; oboInOwl:creation_date "2011-02-24T08:20:08Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "cervical canal epithelial cell", "cervical canal of uterus epithelial cell", "cervix epithelial cell", "cervix of uterus epithelial cell", "epithelial cell of cervical canal", "epithelial cell of cervical canal of uterus", "epithelial cell of cervix of uterus", "epithelial cell of neck of uterus", "epithelial cell of uterine cervix", "neck of uterus epithelial cell", "uterine cervix epithelial cell" ; a owl:Class ; rdfs:label "epithelial cell of cervix" ; rdfs:subClassOf obo:CL_0002149, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004801 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000002 ] ) ] . obo:CL_0002536 obo:IAO_0000115 "An epithelial cell that is part of the amnion." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-02-28T12:38:01Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "amniotic epithelial cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "epithelial cell of amnion" ; rdfs:subClassOf obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000305 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000305 ] ) ] . obo:CL_0002537 obo:IAO_0000115 "A mesenchymal stem cell of the amnion membrane." ; terms:contributor ; oboInOwl:creation_date "2011-02-28T12:44:24Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "amniotic membrane stem cell" ; a owl:Class ; rdfs:label "amnion mesenchymal stem cell" ; rdfs:subClassOf obo:CL_0000134, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000305 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000305 ] ) ] . obo:CL_0002538 obo:IAO_0000115 "An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes." ; terms:contributor ; terms:description """Intrahepatic cholangiocytes represent a subset of the biliary epithelial cells that form a network of tubes in the liver called the biliary tree The intrahepatic cholangiocytes reside specifically in the intrahepatic bile ducts and play a crucial role in liver physiology and bile production and secretion, thereby aiding in the digestion and absorption of fats in the small intestine. These specific cholangiocytes arise from bipotent hepatoblasts, whereas extrahepatic cholangiocytes share an embryologic origin with the ventral pancreas. Recent research suggests that there is also heterogeneity within populations of intrahepatic cholangiocytes with different transcriptional profiles, proliferative capacity, and biological function; for example, subpopulations differ in calcium-mobilizing receptors. The primary function of intrahepatic cholangiocytes is related to bile formation and maintenance of its flow. In addition to their secretory and absorptive activities, they are involved in the regulation of bile composition, volume, and alkalinization, contributing to the neutralization of the acidic chyme (partly digested food) that enters the intestine from the stomach. Intrahepatic cholangiocytes are also recognized for their role in liver regeneration and repair, often proliferating in response to injury. Intrahepatic cholangiocytes take part in certain pathological conditions, like primary biliary cirrhosis and cholangiocarcinoma. Changes in these cells often lead to abnormalities in bile formation and transport, causing cholestatic liver diseases. Overall, the primary and secondary functional activities of intrahepatic cholangiocytes are vital in maintaining liver function, digestive processes, and contributing to the body's response to liver injury. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2011-02-28T01:20:20Z"^^xsd:dateTime ; oboInOwl:hasDbXref "ZFA:0009379" ; oboInOwl:hasExactSynonym "small bile duct cholangiocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "intrahepatic cholangiocyte" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002538" ; rdfs:subClassOf obo:CL_1000488, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004823 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000488 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004823 ] ) ] . obo:CL_0002539 obo:IAO_0000115 "A smooth muscle cell of the aorta." ; terms:contributor ; terms:description """Aortic smooth muscle cells are specialized and highly differentiated muscle cells that are located in the tunica media layer of the aorta. They consist of spindle-shaped cells with a centrally located nucleus. These cells are rich in actin and myosin, muscle contractile proteins, that allow them to exert force and change shape. Aortic smooth muscle cells play a vital role in maintaining blood pressure and circulation, and are essential for vascular integrity and function. The primary function of these cells is contraction and relaxation, which enables the regulation of blood flow and pressure in the aorta, and helps in the distribution of oxygen and nutrients throughout the body. Additionally, a critical characteristic of smooth muscle cells is their plasticity. They can undergo phenotypic modulation in response to changes in their environment or vascular injury, switching from a contractile to a synthetic phenotype. The contractile phenotype is characterized by high contractility and low proliferation rate, while the synthetic phenotype is marked by increased cell proliferation and matrix synthesis but reduced contractile function. Aortic smooth muscle cells have a significant role in the physiological and pathological processes of the cardiovascular system. In the normal physiological state, they contribute to the elasticity and flexibility of the aorta. Conversely, in pathological states, changes in the function and structure of aortic smooth muscle cells are connected with various vascular diseases, including atherosclerosis, hypertension, and aneurysm. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2011-02-28T01:42:12Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004577" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "aortic smooth muscle cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002539" ; rdfs:subClassOf obo:CL_0019018, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004178 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004178 ] ) ] . obo:CL_0002540 obo:IAO_0000115 "A mesenchymal stem cell that is part of the bone marrow." ; terms:contributor ; oboInOwl:creation_date "2011-02-28T01:47:47Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "mesenchymal stem cell of the bone marrow" ; rdfs:subClassOf obo:CL_0000134, obo:CL_0002092 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] ) ] . obo:CL_0002541 obo:IAO_0000115 "A mesenchymal stem cell of the chorionic membrane." ; terms:contributor ; oboInOwl:creation_date "2011-02-28T03:04:35Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "chorionic membrane mesenchymal stem cell" ; rdfs:subClassOf obo:CL_0000134, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003124 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003124 ] ) ] . obo:CL_0002542 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_1000413 ; a owl:Class ; owl:deprecated true . obo:CL_0002543 obo:IAO_0000115 "An endothelial cell that is part of the vein." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Vein endothelial cells form a thin layer of squamous cells, the endothelium, lining the interior surface of veins throughout the body. They shape the inner cellular lining of the entire vascular system, including the heart, playing a crucial role in blood circulation. The unique characteristic compact arrangement of these cells enables veins to act as a barrier between the blood (that can contain foreign substances) and the surrounding venous tissue and maintain the integrity of the vascular system. The primary function of vein endothelial cells is to control the exchange of substances between the bloodstream and the surrounding tissues. They facilitate selective transportation of molecules depending on their size and solubility, including gases, nutrients, hormones, and waste products. Vein endothelial cells also play a protective role by inhibiting the translocation of toxins or pathogens from blood to tissues. Additionally, these cells are involved in blood coagulation and inflammation response, primarily by producing substances that inhibit blood clot formation under normal conditions and initiating clotting when necessary. Another significant function of vein endothelial cells is the regulation of blood flow and blood pressure. They produce and release several substances, including nitric oxide and prostacyclin, which help in controlling vasodilation and vasoconstriction, thereby regulating blood pressure. These cells are also responsible for angiogenesis, the formation of new blood vessels, which is crucial during wound healing and in the formation of granulation tissue. Consequently, any dysfunction in vein endothelial cells can lead to severe health problems like atherosclerosis, hypertension, and thrombosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2011-02-28T03:48:11Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:62104", "KUPO:0001099" ; oboInOwl:hasExactSynonym "endothelial cell of vein", "venous endothelial cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "vein endothelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002543" ; rdfs:subClassOf obo:CL_0000071, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001638 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000071 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001638 ] ) ] . obo:CL_0002544 obo:IAO_0000115 "An arterial endothelial cell that is part of the aorta endothelium." ; terms:contributor ; oboInOwl:creation_date "2011-02-28T03:54:42Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0003245", "CALOHA:TS-0047" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "aortic endothelial cell" ; rdfs:subClassOf obo:CL_1000413 . obo:CL_0002545 obo:IAO_0000115 "An endothelial cell that is part of the thoracic endothelium." ; terms:contributor ; oboInOwl:creation_date "2011-02-28T03:59:09Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "thoracic aorta endothelial cell" ; rdfs:subClassOf obo:CL_0002544, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001515 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001515 ] ) ] . obo:CL_0002546 obo:IAO_0000115 "An endothelial progenitor cell that participates in angiogenesis during development." ; terms:contributor ; oboInOwl:creation_date "2011-02-28T04:20:39Z"^^xsd:dateTime ; oboInOwl:hasDbXref "ZFA:0005773" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "See CL:0002619." ; rdfs:label "embryonic blood vessel endothelial progenitor cell" ; rdfs:subClassOf obo:CL_0000222 . obo:CL_0002547 obo:IAO_0000115 "A fibroblast of the aortic adventitia." ; terms:contributor ; oboInOwl:creation_date "2011-02-28T04:43:41Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "fibroblast of the aortic adventitia" ; rdfs:subClassOf obo:CL_1000306, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004664 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000306 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004664 ] ) ] . obo:CL_0002548 obo:IAO_0000115 "A fibroblast that is part of the heart." ; terms:contributor ; oboInOwl:creation_date "2011-02-28T04:57:44Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "cardiac fibroblast" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "fibroblast of cardiac tissue" ; rdfs:subClassOf obo:CL_0000057, obo:CL_0002494, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:CL_0002549 obo:IAO_0000115 "A fibroblast that is part of the choroid plexus." ; terms:contributor ; oboInOwl:creation_date "2011-02-28T05:01:39Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "fibroblast of choroid plexus" ; rdfs:subClassOf obo:CL_0000057, obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001886 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001886 ] ) ] . obo:CL_0002550 obo:IAO_0000115 "A fibroblast that is part of the conjuctiva of the eye." ; terms:contributor ; oboInOwl:creation_date "2011-02-28T05:03:44Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "fibroblast of the conjunctiva" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001811 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001811 ] ) ] . obo:CL_0002551 obo:IAO_0000115 "Any skin fibroblast that is part of some dermis." ; terms:contributor ; oboInOwl:creation_date "2011-02-28T05:05:33Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "fibroblast of dermis" ; rdfs:subClassOf obo:CL_0002620, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002620 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] ) ] . obo:CL_0002552 obo:IAO_0000115 "Any fibroblast that is part of some gingiva." ; terms:contributor ; oboInOwl:creation_date "2011-02-28T05:09:12Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "fibroblast of gingiva" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001828 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001828 ] ) ] . obo:CL_0002553 obo:IAO_0000115 "A fibroblast that is part of lung." ; terms:contributor ; oboInOwl:creation_date "2011-02-28T05:11:03Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0000764", "CALOHA:TS-0575" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "fibroblast of lung" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:CL_0002554 obo:IAO_0000115 "A fibroblast of the lymphatic system." ; terms:contributor ; oboInOwl:creation_date "2011-02-28T05:16:18Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "fibroblast of lymphatic vessel" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001473 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001473 ] ) ] . obo:CL_0002555 obo:IAO_0000115 "A fibroblast that is part of the mammary gland." ; terms:contributor ; oboInOwl:creation_date "2011-02-28T05:18:38Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "fibroblast of mammary gland" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ) ] . obo:CL_0002556 obo:IAO_0000115 "A fibroblast of the periodontium." ; terms:contributor ; oboInOwl:creation_date "2011-02-28T05:19:48Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "fibroblast of periodontium" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001758 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001758 ] ) ] . obo:CL_0002557 obo:IAO_0000115 "A fibroblast of pulmonary artery." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-02-28T05:22:27Z"^^xsd:dateTime ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "fibroblast of pulmonary artery" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002012 ] ) ] . obo:CL_0002558 obo:IAO_0000115 "A fibroblast that is part of villous mesenchyme." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-02-28T05:24:28Z"^^xsd:dateTime ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "fibroblast of villous mesenchyme" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] . obo:CL_0002559 obo:IAO_0000115 "An animal cell that is part of a hair follicle." ; terms:contributor ; oboInOwl:creation_date "2011-03-01T04:11:01Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "hair follicle cell" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002073 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002073 ] ) ] . obo:CL_0002560 obo:IAO_0000115 "An epithelial cell that resides in the inner root sheath of the hair follicle." ; terms:contributor ; oboInOwl:creation_date "2011-03-01T04:27:51Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "inner root sheath cell" ; rdfs:subClassOf obo:CL_0000362, obo:CL_0002559, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005941 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002559 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005941 ] ) ] . obo:CL_0002561 obo:IAO_0000115 "An epithelial cell that is part of the outer root sheath." ; terms:contributor ; oboInOwl:creation_date "2011-03-01T04:29:47Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "outer root sheath cell" ; rdfs:subClassOf obo:CL_0000362, obo:CL_0002559, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005942 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005942 ] ) ] . obo:CL_0002562 obo:IAO_0000115 "An epidermal cell that is part of the germinal matrix." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-03-01T04:31:06Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "trichocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "hair germinal matrix cell" ; rdfs:subClassOf obo:CL_0000362, obo:CL_0002559, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006004 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000362 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006004 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-hair-follicle/v1.0/assets/2d-ftu-skin-hair-follicle.png" . obo:CL_0002563 obo:IAO_0000115 "An epithelial cell of the lining of the intestine." ; terms:contributor ; oboInOwl:creation_date "2011-03-01T05:18:31Z"^^xsd:dateTime ; oboInOwl:hasDbXref "ZFA:0009399" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "intestinal epithelial cell" ; rdfs:subClassOf obo:CL_0002251, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001277 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001277 ] ) ] . obo:CL_0002564 obo:IAO_0000115 "A connective tissue cell of the nucleus pulposus cell of intervertebral disc." ; terms:contributor ; oboInOwl:creation_date "2011-03-02T02:12:23Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "nucleus pulposus cell of intervertebral disc" ; rdfs:subClassOf obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002242 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002320 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002242 ] ) ] . obo:CL_0002565 obo:IAO_0000115 "A pigment cell located in the epithelium of the iris." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-03-01T05:28:52Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "iris pigment epithelial cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0000342, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002506 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000342 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002506 ] ) ] . obo:CL_0002566 obo:IAO_0000115 "A melanocyte that appears darker due to content or amount of melanin granules." ; terms:contributor ; oboInOwl:creation_date "2011-03-01T05:57:11Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "melanotic melanocyte", "melanotic melanophore" ; a owl:Class ; rdfs:label "dark melanocyte" ; rdfs:subClassOf obo:CL_0000148 . obo:CL_0002567 obo:IAO_0000115 "A melanocyte that appears lighter in color." ; terms:contributor ; oboInOwl:creation_date "2011-03-01T05:58:23Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "amelanotic melanocyte", "amelanotic melanophore" ; a owl:Class ; rdfs:label "light melanocyte" ; rdfs:subClassOf obo:CL_0000148 . obo:CL_0002568 obo:IAO_0000115 "A mesenchymal stem cell that is part of Wharton's jelly." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-03-01T09:51:18Z"^^xsd:dateTime ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mesenchymal stem cell of Wharton's jelly" ; rdfs:subClassOf obo:CL_0002569 . obo:CL_0002569 obo:IAO_0000115 "A mesenchymal stem cell of the umbilical cord." ; terms:contributor ; oboInOwl:creation_date "2011-03-01T09:55:12Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "mesenchymal stem cell of umbilical cord" ; rdfs:subClassOf obo:CL_0000134, obo:CL_0000349, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003422 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003422 ] ) ] . obo:CL_0002570 obo:IAO_0000115 "A mesenchymal stem cell of adipose tissue." ; terms:contributor ; terms:description """Mesenchymal stem cells of adipose tissue, also known commonly as adipose-derived stem cells (ADSCs), are a population of adult stem cells that can be obtained easily from adipose tissues. They have many of the same regenerative properties as other mesenchymal stem cells, but are more easily accessible than bone marrow-derived stem cells. Adipose-derived stem cells show immense promise in the field of regenerative medicine due to their ability to differentiate into adipocytes, chondrocytes, myocytes, osteoblasts, and other cell types. ADSCs also possess immunomodulatory and homeostatic functions: they have the ability to suppress immune responses and provide a therapeutic environment for tissue repair and regeneration, as well as supporting the proliferation of adipocytes and the overall expansion of adipose tissue and contributing to the tissue's ability to react to demands of energy storage and mobilization. Dysfunction of these cells may contribute to metabolic complications observed in obesity and diabetes. ADSCs have been used for therapeutic applications such as pathological wound healing, severe refractory acute graft-versus-host disease, and idiopathic thrombocytopenic purpura. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2011-03-01T09:57:17Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "mesenchymal stem cell of adipose" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "mesenchymal stem cell of adipose tissue" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002570" ; rdfs:subClassOf obo:CL_0000134, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001013 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001013 ] ) ] . obo:CL_0002571 obo:IAO_0000115 "A mesenchymal stem cell of liver." ; terms:contributor ; oboInOwl:creation_date "2011-03-01T09:58:51Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "hepatic mesenchymal stem cell" ; rdfs:subClassOf obo:CL_0000134, obo:CL_0002195 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:CL_0002572 obo:IAO_0000115 "A mesenchymal stem cell of the vertebrae." ; terms:contributor ; oboInOwl:creation_date "2011-03-01T10:40:27Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "vertebral mesenchymal stem cell" ; rdfs:subClassOf obo:CL_0000134, obo:CL_0001035, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002412 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002412 ] ) ] . obo:CL_0002573 obo:IAO_0000115 "A glial cell that myelinates or ensheathes axons in the peripheral nervous system." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Schwann cells, also known as neurolemmocytes, are a type of glial cell located in the peripheral nervous system. These cells play a significant role in the healthy functioning of nerves by producing myelin, a fatty substance that forms a coating around nerve fibers. Myelin serves as an insulator and enhances the speed and efficiency of electrical nerve impulses; a single Schwann cell can myelinate a single axon. Myelination starts by the elongation and envelopment of the Schwann cell around the axon, followed by the synthesis and deposition of myelin layers. Some studies suggest that Schwann cells may regulate neuronal action potential, muscular contraction, and the sensitive response. While Schwann cells are most commonly known for the formation of the myelin sheath, some Schwann cells do not form myelin: Remak Schwann cells, a class of nonmyelinating Schwann cells, ensheath axons with smaller diameter, such as C fiber nociceptors in sciatic nerves and form Remak bundles. Schwann cells are found along both motor and sensory neurons and are crucial for the advancement and recovery of peripheral nerve injuries, due to their capacity to support nerve regeneration. In cases of nerve injury, Schwann cells play a vital role in recovery by initiating Wallerian degeneration, a process in which the part of the axon distal to the injury site degrades and is then cleared away. Following this, Schwann cells can guide the regrowth of the nerve, providing a conducive environment for axon regeneration. They remodel themselves into a regenerative phenotype, proliferate, and organize themselves into bands of Büngner that provide physical and chemical guidance for the regrowths of axons. This function of Schwann cells in the repair and regeneration of nervous system highlights their therapeutic potential in peripheral nerve injury treatments. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2011-03-02T01:19:27Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0001220", "CALOHA:TS-0898", "MESH:D012583" ; oboInOwl:hasExactSynonym "neurolemmocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "A myelinating Schwann cell wraps around a single axon. Myelination occurs in larger diameter axons, while a process called ensheathment occurs on smaller diameter axons in which a single cell wraps around multiple small, unmyelinated axons separating them with a thin layer of cytoplasm. The structure formed is called a Remak bundle." ; rdfs:label "Schwann cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002573" ; rdfs:subClassOf obo:CL_0000125, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000010 ] . obo:CL_0002574 obo:IAO_0000115 "A stromal cell of the pancreas." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-03-02T02:40:41Z"^^xsd:dateTime ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "stromal cell of pancreas" ; rdfs:subClassOf obo:CL_0000499, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:CL_0002575 obo:IAO_0000115 "A pericyte of the central nervous system." ; terms:contributor ; oboInOwl:creation_date "2011-03-02T02:54:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "central nervous system pericyte" ; rdfs:subClassOf obo:CL_0000669, obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000669 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] . obo:CL_0002576 obo:IAO_0000115 "A glial cell that is part of the perineurium. This cell type has thin long bipolar cytoplasmic processes, pinocytotic vesicles, fragments of external lamina and/or external lamina-like material, attachment plaques, and desmosome-like junctions. Perineurial cells historically have been referred to as fibroblasts because of shape; however, unlike fibroblasts, a perineurial cell: does not have a compact nucleus and large endoplasmic reticulum; does have a double basement membrane opposed to a single basal lamina; is carefully joined to other perineurial cells by tight junctions into a single sheet as opposed to arranged in a large mass; and finally, can surround a small axon bundle at a nerve terminal whereas a fibroblast cannot." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; oboInOwl:creation_date "2011-03-02T03:03:58Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "perineurial glial cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "There are studies that largely accept the idea that the perineurial cell is a modified fibroblast with myofibroblastic features." ; rdfs:label "perineurial cell" ; rdfs:subClassOf obo:CL_0000125, obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000121 ] . obo:CL_0002577 obo:IAO_0000115 "An epithelial cell of the placenta." ; terms:contributor ; oboInOwl:creation_date "2011-03-02T03:21:30Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "placental epithelial cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0000349, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:CL_0002578 obo:IAO_0000115 "A preadipocyte found in mesenteric tissue." ; terms:contributor ; oboInOwl:creation_date "2011-03-03T04:19:40Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "mesenteric preadipocyte" ; rdfs:subClassOf obo:CL_0002334, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002095 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002334 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002095 ] ) ] . obo:CL_0002579 obo:IAO_0000115 "A preadipocyte that is part of an omentum." ; terms:contributor ; oboInOwl:creation_date "2011-03-03T04:19:42Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "omentum preadipocyte" ; rdfs:subClassOf obo:CL_0002334, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003688 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002334 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003688 ] ) ] . obo:CL_0002580 obo:IAO_0000115 "A preadipocyte that is part of the breast." ; terms:contributor ; oboInOwl:creation_date "2011-03-03T04:19:46Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "preadipocyte of the breast" ; rdfs:subClassOf obo:CL_0002334, obo:CL_4006000 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002334 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000310 ] ) ] . obo:CL_0002581 obo:IAO_0000115 "A preadipocyte that is part of a perirenal fat tissue." ; terms:contributor ; oboInOwl:creation_date "2011-03-03T04:20:04Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "perirenal preadipocyte" ; rdfs:subClassOf obo:CL_0002334, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005406 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002334 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005406 ] ) ] . obo:CL_0002582 obo:IAO_0000115 "A preadipocyte that is part of visceral tissue." ; terms:contributor ; oboInOwl:creation_date "2011-03-03T04:32:56Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "visceral preadipocyte" ; rdfs:subClassOf obo:CL_0002334 . obo:CL_0002583 obo:IAO_0000115 "A preadipocyte that is part of subcutaneous tissue." ; terms:contributor ; oboInOwl:creation_date "2011-03-03T04:33:01Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "subcutaneous preadipocyte" ; rdfs:subClassOf obo:CL_0002334, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002072 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002334 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002072 ] ) ] . obo:CL_0002584 obo:IAO_0000115 "An epithelial cell of the kidney cortex." ; oboInOwl:hasDbXref "KUPO:0001016" ; a owl:Class ; rdfs:label "renal cortical epithelial cell" ; rdfs:subClassOf obo:CL_0002518, obo:CL_0002681 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002518 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001225 ] ) ] . obo:CL_0002585 obo:IAO_0000115 "A blood vessel endothelial cell that is part of the retina." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Retinal blood vessel endothelial cells constitute the innermost lining of the blood vessels found in the retina, the light-sensitive layer of tissue at the back of the eye. The primary role of these cells revolves around their location within the retinal vascular system, forming the structure of the blood-retinal barrier, a subset of the larger blood-ocular barrier system. The endothelial cells are particularly involved in the growth of new retinal blood vessels from pre-existing ones (angiogenesis); this is critical in managing the amount of oxygen and essential nutrients delivered to the ocular tissues. They are crucial for maintaining homeostasis in the retinal environment by controlling the exchange of molecules between the blood and the retina. Furthermore, they mediate immune cell trafficking, supporting the immune privilege of the eye by preventing the unrestricted infiltration of inflammatory cells into the retina, thus maintaining ocular health and normal vision. The malfunction or dysfunction of retinal blood vessel endothelial cells is implicated in numerous ocular pathologies, particularly diabetic retinopathy, which is one of the leading causes of blindness worldwide. In such conditions, the compromise in the integrity of the blood-retinal barrier and excess angiogenesis can lead to retinal edema and pathological neovascularization, resulting in vision loss. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2011-03-06T03:28:27Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "retinal blood vessel endothelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002585" ; rdfs:subClassOf obo:CL_0000071, obo:CL_0009004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000071 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] . obo:CL_0002586 obo:IAO_0000115 "An epithelial cell of the retinal pigmented epithelium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Retinal pigment epithelial (RPE) cells form a single layer of cells at the back of the eye sandwiched between the neurosensory retina and the choroid, playing a significant role in maintaining vision health. These pigment-laden cells are highly specialized and perform an array of metabolic and transport functions essential for the maintenance of the photoreceptor cells (rods and cones) in the retina. The pigmentation of RPE cells actively aids in the absorption of excess light and the prevention of light scattering, thus enhancing the eye's optical properties. The retinal pigment epithelium forms a key part of the blood/retina barrier. The cells have long sheet-like microvilli on their apical membrane that project into the light-sensitive outer segments of the photoreceptors, forming a close structural interaction. The basolateral membrane of the RPE interacts with the underlying Bruch’s membrane, which separates the RPE cells from fenestrated endothelium of the choriocapillaris. RPE cells support the photoreceptor by providing them with oxygen and nutrients (such as glucose, retinol and fatty acids) and removing waste products. They also recycle the visual pigment, in a process called the \"visual cycle\", where the RPE cells play a vital role in the regeneration of visual pigment (11-cis retinol) following the absorption of light. This is essential for the maintenance of photoreceptor excitability. Beyond this, RPE cells take part in the phagocytosis process, where they digest the shed ends of photoreceptor outer segments, thus, preventing the build-up of waste residue that could otherwise harm retinal health. They also secrete various factors, including growth factors required to maintain the structural integrity of choriocapillaris endothelium and photoreceptors, as well as immunosuppressive factors that play an important role in establishing the immune privilege of the eye. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2011-03-06T03:37:09Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004910", "FMA:75802" ; oboInOwl:inSubset cl:cellxgene_subset, cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "retinal pigment epithelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002586" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0000149, obo:CL_0009004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001782 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042470 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001782 ] ) ] . obo:CL_0002587 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002140 ; a owl:Class ; owl:deprecated true . obo:CL_0002588 obo:IAO_0000115 "A smooth muscle cell of the umbilical vein." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T05:00:51Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "smooth muscle cell of the umbilical vein" ; rdfs:subClassOf obo:CL_0019018, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002066 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002066 ] ) ] . obo:CL_0002589 obo:IAO_0000115 "A smooth muscle cell of the bachiocephalic vasculature." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T05:00:58Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "smooth muscle cell of the brachiocephalic vasculature" ; rdfs:subClassOf obo:CL_0019018, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001529 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001529 ] ) ] . obo:CL_0002590 obo:IAO_0000115 "A vascular associated smooth muscle cell of the brain vasculature." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T05:01:20Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "smooth muscle cell of the brain vasculature" ; rdfs:subClassOf obo:CL_0000359, obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:CL_0002591 obo:IAO_0000115 "A smooth muscle of the pulmonary artery." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Smooth muscle cells of the pulmonary artery form a principal component of the pulmonary artery's media layer, the middle section of the artery wall typically found between endothelial inner layer (intima) and the outermost connective tissue layer (adventitia). The unique structure of these cells, defined by fusiform shape and the absence of striations, sets them apart from other muscle cell types, including cardiac and skeletal. The primary function of smooth muscle cells of the pulmonary artery is to regulate the diameter of the pulmonary artery, which in turn controls the flow of blood into the lungs. They accomplish this task through the contraction and relaxation, indicative of vasoconstriction and vasodilation respectively. When these cells contract, the diameter of the artery narrows, leading to reduced blood flow. Conversely, relaxation of these cells widens the artery, facilitating increased blood flow. Such blood flow modulation is crucial for the maintenance of blood pressure and ensuring that the lungs receive an adequate blood supply for efficient oxygen exchange. As a result, abnormal function or proliferation of these cells can contribute to conditions such as pulmonary hypertension, a condition characterized by high blood pressure in the arteries leading to the lungs. This can occur due to hypoxia (lack of enough oxygen), leading to excessive constriction or proliferation of the smooth muscle cells. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2011-03-06T05:01:28Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0003336" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "smooth muscle cell of the pulmonary artery" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002591" ; rdfs:subClassOf obo:CL_0019018, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002012 ] ) ] . obo:CL_0002592 obo:IAO_0000115 "A smooth muscle cell of the coronary artery." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-03-06T05:01:34Z"^^xsd:dateTime ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "smooth muscle cell of the coronary artery" ; rdfs:subClassOf obo:CL_0002494, obo:CL_0019018, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001621 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001621 ] ) ] . obo:CL_0002593 obo:IAO_0000115 "A smooth muscle of the internal thoracic artery." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T05:01:41Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "smooth muscle cell of the internal thoracic artery" ; rdfs:subClassOf obo:CL_0002595, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002456 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002456 ] ) ] . obo:CL_0002594 obo:IAO_0000115 "A smooth muscle cell of the umbilical artery." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T05:01:48Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "smooth muscle cell of the umbilical artery" ; rdfs:subClassOf obo:CL_0019018, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001310 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001310 ] ) ] . obo:CL_0002595 obo:IAO_0000115 "A smooth muscle cell of the subclavian artery." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T05:01:52Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "smooth muscle cell of the subclavian artery" ; rdfs:subClassOf obo:CL_0019018, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001533 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001533 ] ) ] . obo:CL_0002596 obo:IAO_0000115 "Smooth muscle cell of the carotid artery." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T05:01:56Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "smooth muscle cell of the carotid artery" ; rdfs:subClassOf obo:CL_0019018, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005396 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005396 ] ) ] . obo:CL_0002597 obo:IAO_0000115 "A smooth muscle cell of the bladder." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-03-06T05:43:24Z"^^xsd:dateTime ; oboInOwl:hasDbXref "KUPO:0001122" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "smooth muscle cell of bladder" ; rdfs:subClassOf obo:CL_0000192, obo:CL_1001319 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] . obo:CL_0002598 obo:IAO_0000115 "Any smooth muscle cell that is part of some bronchus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Bronchial smooth muscle cells are specialized types of cells found in the bronchi of the respiratory system in mammals. These bronchi are tubular structures that function to carry air from the trachea into the lungs. As part of the smooth muscle tissue, bronchial smooth muscle cells are involuntary cells, meaning they function with minimal direct voluntary control. They are characterized by their elongated spindle-shaped structure, with each cell containing a single central nucleus. The primary function of bronchial smooth muscle cells is to control airway diameter, which directly influences the flow of air into and out of the lungs. Muscular contractions and relaxations mediated by these cells enable the bronchi to constrict or expand, facilitating the regulation of respiratory airflow. Additionally, these cells play a pivotal role in immune responses as they produce and release various substances that can instigate or lessen inflammation of airway tissue. Furthermore, bronchial smooth muscle cells can proliferate and lay down collagen and other extracellular matrix proteins, contributing to the structural integrity of the bronchial tubes. In pathological conditions, such as asthma and chronic obstructive pulmonary disease, the function and biology of bronchial smooth muscle cells change. Asthma, for example, is associated with an abnormal increase in the mass of the bronchial smooth muscles, leading to narrowing of the airways and resultant breathing difficulties. These cells also exhibit altered contractile behavior and an augmented immune response during inflammatory lung diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2011-03-06T05:46:39Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004402" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "bronchial smooth muscle cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002598" ; rdfs:subClassOf obo:CL_0019019, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:CL_0002599 obo:IAO_0000115 "A smooth muscle cell of the esophagus." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T05:48:17Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "smooth muscle cell of the esophagus" ; rdfs:subClassOf obo:CL_0000192, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:CL_0002600 obo:IAO_0000115 "A smooth muscle cell of the trachea." ; terms:contributor ; terms:description """Smooth muscle cells of the trachea have a characteristic 'smooth' (non-striated) appearance under the microscope, a distinguishing feature that differentiates them from skeletal and cardiac muscle cells. The smooth appearance is due to the organization of actin and myosin filaments in the cell, which allows for a controlled, contractile function. These cells play a key role in controlling the diameter of the trachea, thus regulating the airflow. They are responsible for the involuntary constriction and relaxation of the trachea influencing the air passage during various physiological behaviors like breathing, coughing, and sneezing. This autonomic control allows for adaptations to specific body requirements without conscious control, such as increasing air flow during exercise or restricting it during rest. In conditions such as asthma, chronic bronchitis, and emphysema, there are changes in smooth muscle cells. For example, the mass of smooth muscle cells increases in chronic airway diseases, possibly in response to chronic inflammation. This increase may indicate a pathological condition or be a part of the body's response to injury and repair. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2011-03-06T05:50:28Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "smooth muscle cell of trachea" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002600" ; rdfs:subClassOf obo:CL_0019019, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] . obo:CL_0002601 obo:IAO_0000115 "A smooth muscle cell of the uterus." ; terms:contributor ; terms:description """Uterine smooth muscle cells are specialized cells that make up the majority of the uterus and in particular, the myometrium. The myometrium is a thick, involuntary muscle layer, principally consisting of verticillate cell bundles that sculpt the helical architecture of the uterus. This dense muscular tissue, packed with uterine smooth muscle cells, is responsible for the significant contractile force witnessed during the physical processes of labor and childbirth. In the non-pregnant uterus, they exist in a quiescent phase. Upon implantation, these cells are primarily responsible for the expansion consequently allowing the uterus to accommodate the growing fetus. Towards the end of pregnancy, under the influence of hormonal and mechanical signals, uterine smooth muscle cells transition from a relaxed phase to an active contractile phase, culminating in the delivery of the fetus. At the cellular level, these transitions involve significant changes in the electrophysiological properties of uterine smooth muscle cells. Governed by a complex interplay of ion channels, transporters, and signaling proteins, these cells adjust their electrical activity, conduction properties, and contracting mechanisms. Any issues with these processes can result in problems such as preterm birth or labor dysfunction. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2011-03-06T05:53:28Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "uterine smooth muscle cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002601" ; rdfs:subClassOf obo:CL_0000192, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ) ] . obo:CL_0002602 obo:IAO_0000115 "Any connective tissue cell that is part of some annulus fibrosus disci intervertebralis." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T06:50:53Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "anulus pulposus cell" ; a owl:Class ; rdfs:label "annulus pulposus cell" ; rdfs:subClassOf obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004715 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002320 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004715 ] ) ] . obo:CL_0002603 obo:IAO_0000115 "An astrocyte of the cerebellum." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T06:57:27Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "astrocyte of the cerebellum" ; rdfs:subClassOf obo:CL_0000127, obo:CL_2000005, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002037 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000127 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] . obo:CL_0002604 obo:IAO_0000115 "An astrocyte that is part of the hippocampus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-03-06T06:57:33Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "astrocyte of the hippocampal formation", "astrocyte of the hippocampus" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "hippocampal astrocyte" ; rdfs:subClassOf obo:CL_0002605, obo:CL_1001580 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000127 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002421 ] ) ] . obo:CL_0002605 obo:IAO_0000115 "A transcriptomically distinct astrocyte that is found in the cerebral cortex." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-03-06T06:57:36Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "astrocyte of the cerebral cortex" ; rdfs:subClassOf obo:CL_0012000, obo:CL_1001579 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000127 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] . obo:CL_0002606 obo:IAO_0000115 "An astrocyte of the spinal cord." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T07:11:26Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "astrocyte of the spinal cord" ; rdfs:subClassOf obo:CL_0000127, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000127 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:CL_0002607 obo:IAO_0000115 "A neural crest cell that gives rise to cells of the enteric nervous system." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T07:24:35Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "migratory enteric neural crest cell" ; rdfs:subClassOf obo:CL_0000333 . obo:CL_0002608 obo:IAO_0000115 "A neuron with a soma found in the hippocampus." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T07:31:49Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "hippocampal neuron" ; rdfs:subClassOf obo:CL_0010012, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002421 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002421 ] ) ] ; skos:prefLabel "hippocampal neuron" . obo:CL_0002609 obo:IAO_0000115 "OBSOLETE. A CNS neuron of the cerebral cortex." ; obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0010012 ; terms:contributor ; oboInOwl:creation_date "2011-03-06T07:37:08Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004102", "FMA:84104" ; oboInOwl:hasExactSynonym "cortical neuron" ; a owl:Class ; rdfs:label "obsolete neuron of cerebral cortex" ; owl:deprecated true . obo:CL_0002610 obo:IAO_0000115 "A neuron of the raphe nuclei." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T07:42:06Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "raphe nuclei neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0004684 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0004684 ] ) ] . obo:CL_0002611 obo:IAO_0000115 "A CNS neuron of the dorsal spinal cord." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T07:43:34Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "neuron of the dorsal spinal cord" ; rdfs:subClassOf obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002256 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002256 ] ) ] . obo:CL_0002612 obo:IAO_0000115 "A neuron of the ventral spinal cord." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T07:46:03Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "neuron of the ventral spinal cord" ; rdfs:subClassOf obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002257 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002257 ] ) ] . obo:CL_0002613 obo:IAO_0000115 "A neuron of the striatum." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T07:47:12Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "striatum neuron" ; rdfs:subClassOf obo:CL_0012001, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002435 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002435 ] ) ] . obo:CL_0002614 obo:IAO_0000115 "A neuron of the substantia nigra." ; terms:contributor ; oboInOwl:creation_date "2011-03-06T07:48:42Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "neuron of the substantia nigra" ; rdfs:subClassOf obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002038 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002038 ] ) ] . obo:CL_0002615 obo:IAO_0000115 "An adipocyte that is part of omentum tissue." ; terms:contributor ; oboInOwl:creation_date "2011-03-14T10:17:00Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "omental adipocyte", "omental fat cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "adipocyte of omentum tissue" ; rdfs:subClassOf obo:CL_0000136, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003688 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000136 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003688 ] ) ] . obo:CL_0002616 obo:IAO_0000115 "An adipocyte of perirenal fat tissue." ; terms:contributor ; oboInOwl:creation_date "2011-03-14T10:17:05Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "perirenal adipocyte cell", "perirenal fat cell" ; a owl:Class ; rdfs:label "perirenal adipocyte" ; rdfs:subClassOf obo:CL_0000136, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005406 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000136 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005406 ] ) ] . obo:CL_0002617 obo:IAO_0000115 "An adipocyte that is part of the breast." ; terms:contributor ; oboInOwl:creation_date "2011-03-14T10:17:07Z"^^xsd:dateTime ; oboInOwl:hasDbXref "CALOHA:TS-2377" ; oboInOwl:hasExactSynonym "breast adipocyte", "fat cell of breast" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma.[CALOHA]" ; rdfs:label "adipocyte of breast" ; rdfs:subClassOf obo:CL_0000136, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000310 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000136 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000310 ] ) ] . obo:CL_0002618 obo:IAO_0000115 "An endothelial cell of the umbilical vein." ; terms:contributor ; terms:description """Endothelial cells of the umbilical vein form the inner lining of the veins found in the umbilical cord. They are involved in tube formation and migration which are essential for angiogenesis, the process of generating new blood vessels; this is critical during the fetal stage for the development of the circulatory system. Endothelial cells of the umbilical vein also play a role in controlling the passage of white blood cells into tissues during inflammatory responses. Because human umbilical vein endothelial cells (HUVECs) can easily be derived from the umbilical cord, and because they express common endothelial cell markers, they have been used as an epithelial cell model for studies on cell proliferation, migration, angiogenesis, and inflammation. They have been used as models for vascular diseases like atherosclerosis, for investigating how tumor cells infiltrate blood vessels and form metastases. Thus, while endothelial cells of the umbilical vein play a critical role in vascular biology, they also represent a powerful tool in disease studies and potential treatment strategies. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2011-03-14T11:36:51Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0004296" ; a owl:Class ; rdfs:label "endothelial cell of umbilical vein" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002618" ; rdfs:subClassOf obo:CL_0002543, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002066 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002066 ] ) ] . obo:CL_0002619 obo:IAO_0000115 "An adult angioblastic cell released from the bone marrow, or from the kidney in some teleost species, capable of blood circulation and participation in angiogenesis by differentiating into blood vessel endothelial cells." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-03-14T12:11:18Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "EPC" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "The existence of adult endothelial progenitor cells has been controversial in the past." ; rdfs:label "adult endothelial progenitor cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/1410", "https://github.com/obophenotype/cell-ontology/issues/348" ; rdfs:subClassOf obo:CL_0000566 . obo:CL_0002620 obo:IAO_0000115 "A fibroblast of skin." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-03-14T12:31:49Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0001255", "CALOHA:TS-0935" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "skin fibroblast" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002097 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002097 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-dermal-papilla/v1.1/assets/2d-ftu-skin-dermal-papilla.png" . obo:CL_0002621 obo:IAO_0000115 "Any stratified squamous epithelial cell that is part of some gingival epithelium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-03-14T12:46:28Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "gingival epithelial cell" ; rdfs:subClassOf obo:CL_0000240, obo:CL_1001576, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001949 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000240 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001949 ] ) ] . obo:CL_0002622 obo:IAO_0000115 "A stromal cell of the prostate." ; terms:contributor ; oboInOwl:creation_date "2011-03-14T02:11:10Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0003972" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "prostate stromal cell" ; rdfs:subClassOf obo:CL_0000499, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:CL_0002623 obo:IAO_0000115 "An acinar cell of salivary gland." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-03-14T02:22:22Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "acinar cell of salivary gland" ; rdfs:subClassOf obo:CL_0000622, obo:CL_1001596 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000622 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001044 ] ) ] . obo:CL_0002624 obo:IAO_0000115 "A paneth cell of the appendix." ; terms:contributor ; oboInOwl:creation_date "2011-03-15T09:38:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "paneth cell of the appendix" ; rdfs:subClassOf obo:CL_0000510, obo:CL_1001585 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000510 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ) ] . obo:CL_0002625 obo:IAO_0000115 "A cell of the seminiferous tubule epithelium." ; terms:contributor ; oboInOwl:creation_date "2011-03-15T11:59:23Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "seminiferous tubule epithelial cell" ; rdfs:subClassOf obo:CL_0000068, obo:CL_0000077, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004813 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001343 ] ) ] . obo:CL_0002626 obo:IAO_0000115 "An immature astrocyte." ; oboInOwl:hasExactSynonym "immature astrocytic glia" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "immature astrocyte" ; rdfs:subClassOf obo:CL_0000127 . obo:CL_0002627 obo:IAO_0000115 "A mature astrocyte that is capable of producing cytokines." ; oboInOwl:hasExactSynonym "activated astrocyte", "mature astrocytic glia" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Mature astrocytes are reportedly able to produce aspartate, ATP, BDNF, BMP-2a, BMP-3, CCL2, CCL3, CCL4, CCL5, CCL19, CCL20,CD40L, CNTF, CTGF, CXCL1, CXCL2, CXCL8, edn-1, aFGF, bFGF, G-CSF, glutamate, GM-CSF, IFN-alpha, IFN-beta, IFN-gamma, IGF-1, IL-1alpha, IL-1beta, IL-2, Il-4, IL-6, IL-10, IL-12, LIF, MIP-2, NGF, nitric oxide, NT3, taurine, TGF-beta, TNF-alpha, TNF-beta." ; rdfs:label "mature astrocyte" ; rdfs:subClassOf obo:CL_0000127 . obo:CL_0002628 obo:IAO_0000115 "An immature microglial cell with a ramified morphology." ; oboInOwl:hasExactSynonym "immature microglia", "quiescent microglia", "resting microglia" ; a owl:Class ; rdfs:comment "Immature microglia are reportedly CD34-positive, CD163-negative, MHCI-negative, MHCII-negative." ; rdfs:label "immature microglial cell" ; rdfs:subClassOf obo:CL_0000129 . obo:CL_0002629 obo:IAO_0000115 "A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation." ; terms:description """Mature microglial cells represented one of the macrophage populations within the central nervous system (CNS). Microglial cells serve as the primary immune defense mechanism within the CNS, playing active roles in maintaining brain homeostasis and responding to pathological processes. In response to pathogens and injuries, microglial cells mature and change their morphology from a ramified shape with small processes (normal state) to an amoeboid shape (mature state). Mature microglial cells possess multiple functional abilities, thereby enabling them to execute diverse roles in order to maintain the health of surrounding neural cells. They act to clear away cellular debris, dead neurons, or plaque formations through the process of phagocytosis. They are also continuously scanning their environment and are able to detect subtle changes in the neural landscape caused by injury, disease, or infection. Upon detection of such changes, these cells become activated and present antigens and secrete cytokines and chemokines to initiate an inflammation response, which sustains the brain’s defense against injurious agents. Their role is not solely destructive or defensive: mature microglial cells also contribute to neurodevelopment by guiding the formation of neural circuits, synaptogenesis, and remodeling. Furthermore, they assist in managing synaptic plasticity, a key process in learning and memory functions. While the dysregulation of microglial cells has been implicated in various neurodegenerative diseases, they are also regarded as potential therapeutic targets for such conditions, given their crucial roles in maintaining CNS health. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasExactSynonym "activated microglia", "mature microglia", "reactive microglia" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Mature microglia are reportedly CCR2-positive, CD4-positive, CD9-positive, CD11a-positive, CD11b-positive, CD11c-positive, CD13-positive, CD16-positive, CDw17-positive, CD18-positive, CD21-positive, CD26-negative, CD32-positive, CD35-positive, CD36-positive, CD40-positive, CD44-positive, CD45-positive, CD53-positive, CD54-positive, CD56-negative, CD58-positive, CD63-positive, CD64-positive, CD66-positive, CD80-positive, CD86-positive, CD87-positive, CD92-positive, CD106-positive, CD107a-positive, CD147-positive, CD155-positive, CD162-positive, CD163-positive, CD171-negative, CD200R-positive, CXCR3-positive, CX3CR1-positive, fibronectin-positive, GD3-positive, GLUT1-positive, GLUT3-negative, GLUT5-positive, MHCI-positive, MHCII-positive, P2X4-positive, RFD7-negative, RGS5-negative, alpha-SMA-negative, vimentin-positive, and vwf-negative. Mature microglia are capable of producing BDNF, CCL3, CCL5, CCL7, CCL8, CCL9, CCL19, CCL20,CD40L, CSF, CXCL1, CXCL2, CXCL4, CXCL5, CXCL8, CXCL9, CXCL10, glutamate, IL-1beta, IL-1ra, IL-3, IL-6, IL-10, IL-12, LT, MMP-2, MMP-9, NGF, nitric oxide, ROS, TGF-beta, TNF-alpha." ; rdfs:label "mature microglial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002629" ; rdfs:subClassOf obo:CL_0000129, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002536 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002537 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000129 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002536 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002537 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006909 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0019882 ] ) ] . obo:CL_0002630 obo:IAO_0000115 "A spore formed from bacteria in the order Actinomycetales." ; terms:contributor ; oboInOwl:creation_date "2011-06-16T01:01:41Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "actinomycete-type spore" ; rdfs:subClassOf obo:CL_0000520 . obo:CL_0002631 obo:IAO_0000115 "Any epithelial cell that is part of some upper respiratory tract epithelium." ; terms:contributor ; oboInOwl:creation_date "2011-06-21T12:28:55Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "epithelial cell of upper respiratory tract" ; rdfs:subClassOf obo:CL_0002368, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004814 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004814 ] ) ] ; skos:prefLabel "epithelial cell of upper respiratory tract" . obo:CL_0002632 obo:IAO_0000115 "Any epithelial cell that is part of some lower respiratory tract epithelium." ; terms:contributor ; oboInOwl:creation_date "2011-06-21T12:29:31Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "epithelial cell of lower respiratory tract" ; rdfs:subClassOf obo:CL_0002368, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004815 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004815 ] ) ] . obo:CL_0002633 obo:IAO_0000115 "A basal cell in the respiratory tract." ; terms:contributor ; terms:description """Respiratory basal cells are highly specialized cells that serve a crucial role in the human airway epithelium, predominantly found lining the surfaces of the trachea and bronchi. These cells exhibit a distinctive columnar shape and are attached directly to the basal lamina. They are characterized by the presence of high amounts of cytoplasmic keratins, predominantly keratin 5 and 14, and transcription factor tumor protein (tp63), which set them apart from other types of lung epithelial cells such as ciliated cells and secretory cells. Basal cells are essential for maintaining airway integrity. They make up one third of all respiratory epithelial cells and serve as stem cells as they can transform into different cell types, like goblet cells, ciliated cells, and club cells, when needed for homeostatic maintenance of the epithelial barrier or to repair and restore a healthy cellular environment after injury. Their position at the interface between the internal environment and the external atmosphere makes these cells a first line of defense against air-borne irritants, allergens, and pathogens. Their robust, intrinsic reparative properties facilitate effective recovery from such adversities. However, damage to respiratory basal cells or abnormalities in their function are associated with several respiratory pathologies such as asthma, chronic obstructive pulmonary disease, and lung cancer. Therefore, understanding these cells' function, and their role in disease, is crucial for the development of new therapeutic strategies for respiratory disorders. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2011-06-21T03:11:10Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "airway basal cell", "airway basal stem cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "respiratory basal cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002633" ; rdfs:subClassOf obo:CL_0000646, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004802 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000646 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004802 ] ) ] . obo:CL_0002634 obo:IAO_0000115 "An epithelial cell of the anal column." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T12:11:38Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "epithelial cell of anal column" ; rdfs:subClassOf obo:CL_0002253, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009882 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009882 ] ) ] . obo:CL_0002635 obo:IAO_0000115 "A nonkeratinized epithelial cell of the anal canal." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T02:05:33Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:263146" ; a owl:Class ; rdfs:label "nonkeratinized epithelial cell of anal column" ; rdfs:subClassOf obo:CL_0002634 . obo:CL_0002636 obo:IAO_0000115 "A nonkeratinized cell epithleial cell of the inferior part of the anal canal." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T02:06:53Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:263144" ; a owl:Class ; rdfs:label "nonkeratinized epithelial cell of inferior part of anal canal" ; rdfs:subClassOf obo:CL_0002635, obo:CL_1000438 . obo:CL_0002637 obo:IAO_0000115 "An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T02:08:40Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "keratinized epithelial cell of the anal canal" ; rdfs:subClassOf obo:CL_0000237, obo:CL_0002634 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000237 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000159 ] ) ] . obo:CL_0002638 obo:IAO_0000115 "A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole. This cell types gives rise to alveolar cell types and club cells in response to lung injury. This cell type expresses markers Scgb1a1 and Sftpc." ; terms:contributor , ; oboInOwl:creation_date "2011-06-21T03:26:08Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "BASC", "basal epithelial cell of bronchioalveolar duct junction" ; a owl:Class ; rdfs:label "bronchioalveolar stem cell" ; rdfs:subClassOf obo:CL_0002633, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002051 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004903 ] . obo:CL_0002639 obo:IAO_0000115 "An amniotic stem cell is a mesenchymalstem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue type such as skin, cartilage, cardiac tissue, nerves, muscle, and bone" ; terms:contributor ; oboInOwl:creation_date "2011-06-21T03:55:39Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Not clear to me if amniotic stem cell is a different cell type from amnion mesenchymal stem cells. They are treated as distinct in the literature as isolations methods are different, so I will keep them as separate terms for now." ; rdfs:label "amniotic stem cell" ; rdfs:subClassOf obo:CL_0000134, obo:CL_0002323 . obo:CL_0002640 obo:IAO_0000115 "An epithelial fate stem cell derived form the amnion membrane." ; terms:contributor ; oboInOwl:creation_date "2011-06-21T04:06:17Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "amniotic epithelial stem cell" ; rdfs:subClassOf obo:CL_0000036 . obo:CL_0002641 obo:IAO_0000115 "An epithelial cell of the esophageal gland proper." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T02:16:51Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:256141" ; a owl:Class ; rdfs:label "epithelial cell of esophageal gland proper" ; rdfs:subClassOf obo:CL_0002657 . obo:CL_0002642 obo:IAO_0000115 "An epithelial cell of the esophageal cardiac gland that occurs both in the proximal and distal esophagus, within the lamina propia." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T02:16:54Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:256143" ; a owl:Class ; rdfs:label "epithelial cell of esophageal cardiac gland" ; rdfs:subClassOf obo:CL_0002657 . obo:CL_0002643 obo:IAO_0000115 "An epithelial cell of stratum corneum of esophageal epithelium that lacks keratin." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T02:22:09Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:263148" ; a owl:Class ; rdfs:label "nonkeratinized cell of stratum corneum of esophageal epithelium" ; rdfs:subClassOf obo:CL_0002654 . obo:CL_0002644 obo:IAO_0000115 "An endothelial cell of viscerocranial mucosa that is part of the tympanic region of the viscerocranial mucosa." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T02:25:44Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70628" ; a owl:Class ; rdfs:label "endo-epithelial cell of tympanic part of viscerocranial mucosa" ; rdfs:subClassOf obo:CL_0002261 . obo:CL_0002645 obo:IAO_0000115 "An endocranial viscerocranial mucosa cell that is part of viscerocranial mucosa." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T02:25:46Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70629" ; a owl:Class ; rdfs:label "endo-epithelial cell of pharyngotympanic part of viscerocranial mucosa" ; rdfs:subClassOf obo:CL_0002261 . obo:CL_0002646 obo:IAO_0000115 "An ecto-epithelial cell of the buccal region of the viscerocranial mucosa." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T02:34:12Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70577" ; a owl:Class ; rdfs:label "obsolete epithelial cell of buccal part of viscerocranial mucosa" ; owl:deprecated true . obo:CL_0002647 obo:IAO_0000115 "An ecto-epithelial cell of the palatal region of the viscerocranial mucosa." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T02:34:14Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70580" ; a owl:Class ; rdfs:label "obsolete epithelial cell of anterior palatal part of viscerocranial mucosa" ; owl:deprecated true . obo:CL_0002648 obo:IAO_0000115 "An ecto-epithelial cell of the nasal region of the viscerocranial mucosa." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T02:36:06Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70554" ; a owl:Class ; rdfs:label "obsolete epithelial cell of nasal part of viscerocranial mucosa" ; owl:deprecated true . obo:CL_0002649 obo:IAO_0000115 "An ecto-epithelial cell of the gingival region of the viscerocranial mucosa." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T02:36:11Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70579" ; a owl:Class ; rdfs:label "obsolete epithelial cell of gingival part of viscerocranial mucosa" ; owl:deprecated true . obo:CL_0002650 obo:IAO_0000115 "An ecto-epithelial cell of the paranasal region of the viscerocranial mucosa." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T02:38:18Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70578" ; a owl:Class ; rdfs:label "obsolete epithelial cell of paranasal sinus part of viscerocranial mucosa" ; owl:deprecated true . obo:CL_0002651 obo:IAO_0000115 "An endothelial cell that is part of the venous sinus of spleen. This endothelial cell has an elongated, spindle-shaped, flattened morphology that is parallel to long axis of sinus. This cell type rests on a basement membrane interrupted by numerous narrow slits." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T03:06:49Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:72140" ; oboInOwl:hasExactSynonym "stave cell" ; a owl:Class ; rdfs:label "endothelial cell of venous sinus of spleen" ; rdfs:subClassOf obo:CL_0002262 . obo:CL_0002652 obo:IAO_0000115 "A venule endothelial cell that is cubodial, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-07-08T03:14:10Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "endothelial cell of postcapillary venule of lymph node" ; oboInOwl:hasDbXref "FMA:67759" ; oboInOwl:hasExactSynonym "HEV cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Markers expressed on HEV include: MAdCAM-1,PNAd (sulfated and glycosylated molecules, i.e. GlyCAM-1, CD34, endomucin, nepmucin), ICAM-1, ICAM-2,Fuc-TVII, beta 3GlcNAcT-3, GlcNAc6ST2,CCL21, CCL19, CXCL13, CXCL12, Autotaxin, DARC, angiomodulin, LRHG." ; rdfs:label "endothelial cell of high endothelial venule" ; rdfs:subClassOf obo:CL_1000414, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410037 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002139 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410037 ] ) ] . obo:CL_0002653 obo:IAO_0000115 "A squamous shaped endothelial cell." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T03:31:25Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "squamous endothelial cell" ; rdfs:subClassOf obo:CL_0000115 . obo:CL_0002654 obo:IAO_0000115 "An epithelial cell of stratum corneum of esophageal epithelium." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T03:46:35Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70733" ; a owl:Class ; rdfs:label "epithelial cell of stratum corneum of esophageal epithelium" ; rdfs:subClassOf obo:CL_0002252 . obo:CL_0002655 obo:IAO_0000115 "An epithelial cell of stratum spinosum of esophageal epithelium." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T03:48:26Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:70732" ; a owl:Class ; rdfs:label "epithelial cell of stratum spinosum of esophageal epithelium" ; rdfs:subClassOf obo:CL_0002252 . obo:CL_0002656 obo:IAO_0000115 "A glandular epithelial cell of the endometrium. Following ovulation, these cells secrete a glycogen-rich substance known as histotroph or uterine milk, which nourishes the embryo if implantation occurs." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T03:54:08Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "glandular cell of endometrium" ; oboInOwl:hasDbXref "FMA:86489" ; a owl:Class ; rdfs:label "glandular endometrial unciliated epithelial cell" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000152, obo:CL_0009084, obo:CL_1001591, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002451 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002451 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032940 ] ) ] . obo:CL_0002657 obo:IAO_0000115 "A glandular epithelial cell of the esophagus." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T03:55:57Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:86548" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "glandular cell of esophagus" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0002252 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001976 ] ) ] . obo:CL_0002658 obo:IAO_0000115 "A glandular epithelial cell of the large intestine." ; terms:contributor ; oboInOwl:creation_date "2011-07-08T04:03:01Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:87194" ; a owl:Class ; rdfs:label "glandular cell of the large intestine" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0002253 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] . obo:CL_0002659 obo:IAO_0000115 "A glandular epithelial cell that is part of the stomach." ; terms:contributor ; oboInOwl:creation_date "2011-07-11T01:20:35Z"^^xsd:dateTime ; oboInOwl:hasDbXref "CALOHA:TS-1284", "FMA:86554" ; oboInOwl:hasExactSynonym "glandular cell of stomach" ; a owl:Class ; rdfs:label "glandular epithelial cell of stomach" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0002178 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001276 ] ) ] . obo:CL_0002660 obo:IAO_0000115 "A luminal epithelial cell of mammary gland located in acinus of structure." ; terms:contributor ; oboInOwl:creation_date "2011-07-11T01:44:31Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:74505" ; a owl:Class ; rdfs:comment "Consider if synonymous with mammary alveolar cell CL:0002325. Some use this term to refer to the non-lactating cell type that gives rise to the lactating cell type." ; rdfs:label "luminal cell of acinus of lactiferous gland" ; rdfs:subClassOf obo:CL_0002326 . obo:CL_0002661 obo:IAO_0000115 "A luminal cell of terminal ducts, i.e.e the terminal branch of a lactiferous duct which alveolar cells drain into." ; terms:contributor ; oboInOwl:creation_date "2011-07-11T01:44:33Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:87168" ; a owl:Class ; rdfs:label "luminal cell of lactiferous terminal ductal lobular unit" ; rdfs:subClassOf obo:CL_0002662 . obo:CL_0002662 obo:IAO_0000115 "A luminal epithelial cell of the lactiferous duct. This cuboidal epithelial cell expresses keratin-18 and is estrogen-receptor alpha positive." ; terms:contributor ; oboInOwl:creation_date "2011-07-11T01:44:48Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:74504" ; a owl:Class ; rdfs:label "luminal cell of lactiferous duct" ; rdfs:subClassOf obo:CL_0002326 . obo:CL_0002663 obo:IAO_0000115 "A myocardial endocrine cell that is part of the atrium." ; terms:contributor ; oboInOwl:creation_date "2011-07-11T02:45:39Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:83389" ; a owl:Class ; rdfs:label "myocardial endocrine cell of atrium" ; rdfs:subClassOf obo:CL_0002074, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002081 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002074 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002081 ] ) ] . obo:CL_0002664 obo:IAO_0000115 "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." ; terms:contributor ; oboInOwl:creation_date "2011-07-11T03:15:38Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "cardiovascular progenitor cell" ; oboInOwl:hasRelatedSynonym "CPC" ; a owl:Class ; rdfs:comment "Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell." ; rdfs:label "cardioblast" ; rdfs:subClassOf obo:CL_0000048 . obo:CL_0002665 obo:IAO_0000115 "A fibrocyte of the cochlea that has specialized structural and molecular adaptions." ; terms:contributor ; oboInOwl:creation_date "2011-07-11T03:35:01Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "otic fibrocyte" ; rdfs:subClassOf obo:CL_0000135, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006725 ] . obo:CL_0002666 obo:IAO_0000115 "An otic fibrocyte that underlies the spiral prominence and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." ; terms:contributor ; oboInOwl:creation_date "2011-07-11T03:40:40Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "type II otic fibrocyte", "type II spiral ligament fibrocyte" ; a owl:Class ; rdfs:label "type 2 otic fibrocyte" ; rdfs:subClassOf obo:CL_0002665 . obo:CL_0002667 obo:IAO_0000115 "An otic fibrocyte that resides above the stria vasularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." ; terms:contributor ; oboInOwl:creation_date "2011-07-11T03:40:42Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "type V otic fibrocyte", "type V spiral ligament fibrocyte" ; a owl:Class ; rdfs:label "type 5 otic fibrocyte" ; rdfs:subClassOf obo:CL_0002665 . obo:CL_0002668 obo:IAO_0000115 "An otic fibrocyte that is lateral to the basilar membrane and anchoris it to the lateral wall." ; terms:contributor ; oboInOwl:creation_date "2011-07-11T03:40:46Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "type IV otic fibrocyte", "type IV spiral ligament fibrocyte" ; a owl:Class ; rdfs:label "type 4 otic fibrocyte" ; rdfs:subClassOf obo:CL_0002665 . obo:CL_0002669 obo:IAO_0000115 "An otic fibrocyte that lines the otic capsule." ; terms:contributor ; oboInOwl:creation_date "2011-07-11T03:40:50Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "type III otic fibrocyte", "type III spiral ligament fibrocyte" ; a owl:Class ; rdfs:label "type 3 otic fibrocyte" ; rdfs:subClassOf obo:CL_0002665 . obo:CL_0002670 obo:IAO_0000115 "An otic fibrocyte that underlies the stria vascularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." ; terms:contributor ; oboInOwl:creation_date "2011-07-11T03:39:27Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "type I otic fibrocyte", "type I spiral ligament fibrocyte" ; a owl:Class ; rdfs:label "type 1 otic fibrocyte" ; rdfs:subClassOf obo:CL_0002665 . obo:CL_0002671 obo:IAO_0000115 "An endothelial stalk cell is a specialized endothelial cell that follows behind the tip cell of an angiogenic sprout." ; terms:contributor ; terms:description """Endothelial stalk cells are specialized vascular cells vital in angiogenesis, a process through which new blood vessels are formed from pre-existing ones; specifically, endothelial stalk cells are involved in sprouting angiogenesis, where they help form the body of new blood vessels. Vascular sprouting relies on the coordinated activity of migrating endothelial tip cells at the forefront and proliferating stalk cells that elongate the sprout. The process is tightly controlled by different growths factors: Vascular Endothelial Growth Factor acts on endothelial cells, inducing them to become endothelial tip cells that initiate sprouting. After sprouting initiation, activation of Notch signaling suppresses differentiation toward a tip cell phenotype and some of the endothelial cells differentiate into stalk cells, which follow tip cells, multiply, and elongate to provide a structural backbone to the growing vessel sprout. In contrast to endothelial tip cells, which migrate and lead the angiogenic sprout, endothelial stalk cells behind the sprouts continue forming the tube or lumen for blood flow and facilitate maturation and stability of the new vessel. The delicate balance between the activities of stalk and tip cells during angiogenesis is crucial to build a functional vascular network. Dysfunctions in endothelial stalk cells can lead to pathological conditions such as impaired wound healing, unregulated tumor growth, and metastasis due to abnormal angiogenesis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2011-08-16T01:49:32Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "endothelial stalk cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002671" ; rdfs:subClassOf obo:CL_0000071 . obo:CL_0002672 obo:IAO_0000115 "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." ; terms:contributor ; oboInOwl:creation_date "2011-08-16T02:38:01Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "retinal progenitor cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000048, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000133 ] ; skos:prefLabel "retinal progenitor cell" . obo:CL_0002673 obo:IAO_0000115 "A skeletal muscle cell that is part of the tongue." ; terms:contributor ; terms:description """Tongue muscle cells are responsible for essential functions like mastication, deglutition (swallowing), phonation (speech), and taste receptivity. They can be classified into two functional classes - extrinsic and intrinsic muscle cells. The extrinsic tongue muscle cells originate outside the tongue and are primarily involved in determining the position of the tongue within the mouth. Muscle groups such as the genioglossus, hyoglossus, and styloglossus are composed of these extrinsic muscle cells and grant the tongue its wide range of motion. The intrinsic tongue muscle cells, on the other hand, originate and function within the tongue itself, influencing the shape of the tongue during speech, eating, and swallowing. These cells can contract to alter the tongue's shape, making it long, short, curled, or flat, as needed. Together, these two types of muscle cells allow the tongue to perform its vital functions effectively. Moreover, they play a critical role in maintaining oral health by facilitating physical cleaning of the oral cavity and assisting in the mechanical breakdown of food. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2011-08-16T03:10:02Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "tongue muscle cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002673" ; rdfs:subClassOf obo:CL_0008002, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000378 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0008002 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000378 ] ) ] . obo:CL_0002674 obo:IAO_0000115 "A S. pombe mating type determined by the mat1-Mc and mat1-Mi on the mat1 locus." ; terms:contributor ; oboInOwl:creation_date "2011-08-16T03:20:53Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "H- cell" ; a owl:Class ; rdfs:label "H minus" ; rdfs:subClassOf obo:CL_0000521, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_4896 ] . obo:CL_0002675 obo:IAO_0000115 "A S. pombe cell type determined by mat1-Pc and mat1-Pi on the mat1 locus." ; terms:contributor ; oboInOwl:creation_date "2011-08-16T03:20:58Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "H plus" ; rdfs:subClassOf obo:CL_0000521, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_4896 ] . obo:CL_0002676 obo:IAO_0000115 "A neuroblast derived from a neural crest cell." ; terms:contributor ; oboInOwl:creation_date "2011-08-22T09:24:15Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "neural crest derived neuroblast" ; rdfs:subClassOf obo:CL_0000031, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] ; skos:prefLabel "neural crest derived neuroblast" . obo:CL_0002677 obo:IAO_0000115 "A regulatory T cell that has not encountered antigen." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2011-08-25T03:17:21Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "naive regulatory T lymphocyte", "naive regulatory T-cell", "naive regulatory T-lymphocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type has been described as CD45RA-negative, but this doesn't fit with our current definition of naive T cell." ; rdfs:label "naive regulatory T cell" ; rdfs:subClassOf obo:CL_0000792, obo:CL_0000898 . obo:CL_0002678 obo:IAO_0000115 "A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen." ; terms:contributor ; oboInOwl:creation_date "2011-08-25T03:17:34Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Cell has been described as being CD45RA-positive in human, but this doesn't fit with our current definition memory T cell." ; rdfs:label "memory regulatory T cell" ; rdfs:subClassOf obo:CL_0000792, obo:CL_0000897 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000792 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0043379 ] ) ] . obo:CL_0002679 obo:IAO_0000115 "A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13" ; terms:contributor ; oboInOwl:creation_date "2011-08-29T10:08:02Z"^^xsd:dateTime ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:label "natural helper lymphocyte" ; rdfs:subClassOf obo:CL_0000542, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042105 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001013 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001874 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000542 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042105 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001013 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001874 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ] ) ] . obo:CL_0002680 obo:IAO_0000115 "A PP cell found in intestine." ; terms:contributor ; oboInOwl:creation_date "2011-09-27T11:59:01Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "PP cell of intestine" ; rdfs:subClassOf obo:CL_0000696, obo:CL_1001516 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000696 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001277 ] ) ] . obo:CL_0002681 obo:IAO_0000115 "A cell that is part of a cortex of kidney." ; terms:contributor ; oboInOwl:creation_date "2011-10-25T03:49:41Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "kidney cortical cell" ; rdfs:subClassOf obo:CL_1000497, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001225 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001225 ] ) ] . obo:CL_0003001 obo:IAO_0000115 "A retinal ganglion cell that has dendrites stratified in two layers of the inner-plexiform layer." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasExactSynonym "retinal ganglion D cell" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003001" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "bistratified retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, obo:CL_0004247 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000740 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070062 ] ) ] . obo:CL_0003002 obo:IAO_0000115 "A retinal ganglion cell that has a small dendritic field and a medium dendritic arbor with post sympatic terminals in sublaminar layer S3." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003002" ; a owl:Class ; rdfs:label "G1 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ] . obo:CL_0003003 obo:IAO_0000115 "A mono-stratified retinal ganglion cell that has a small dendritic field and a sparse dendritic arbor with post sympatic terminals in sublaminar layer S3." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003003" ; a owl:Class ; rdfs:label "G2 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ] . obo:CL_0003004 obo:IAO_0000115 "A bistratified retinal ganglion cell that has a small dendritic field with sparse density that terminates at the intersection of the S4-S5 sublaminar level, and a second dendrite field that is medium in size and degree of arborization that terminates in sublaminar layer S2." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003004" ; a owl:Class ; rdfs:comment "is_a bistratified retinal ganglion cell S4-S5 dendrite field having (small dendritic field, sparse density) and second dendrite field having (medium, meduim)" ; rdfs:label "G3 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0003001, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0009851 ] . obo:CL_0003005 obo:IAO_0000115 "A mono-stratified retinal ganglion cell that has a small dendritic field and dense dendritic arbor." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003005" ; a owl:Class ; rdfs:comment "Masland nomenclature PMID:11978858" ; rdfs:label "G4 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ] . obo:CL_0003006 obo:IAO_0000115 "A G4 retinal ganglion cell that has post sympatic terminals in sublaminar layers S3 and S4 and is depolarized by illumination of its receptive field center." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003006" ; a owl:Class ; rdfs:label "G4-ON retinal ganglion cell" ; rdfs:subClassOf obo:CL_0003005, obo:CL_4023032, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0003007 obo:IAO_0000115 "A G4 retinal ganglion cell that has post sympatic terminals in sublaminar layers S2 and S3 and is depolarized by decreased illumination of their receptive field center" ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003007" ; a owl:Class ; rdfs:comment "Masland nomenclature PMID:11978858" ; rdfs:label "G4-OFF retinal ganglion cell" ; rdfs:subClassOf obo:CL_0003005, obo:CL_4023033, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ] . obo:CL_0003008 obo:IAO_0000115 "A mono-stratified retinal ganglion cell that has a medium dendritic field and a medium dendritic arbor with post sympatic terminals in sublaminar layer S2." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003008" ; a owl:Class ; rdfs:label "G5 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ] . obo:CL_0003009 obo:IAO_0000115 "A mono-stratified retinal ganglion cell that has a medium dendritic field and a sparse dendritic arbor with post sympatic terminals in sublaminar layer S4 and S5." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003009" ; a owl:Class ; rdfs:label "G6 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008926 ] . obo:CL_0003010 obo:IAO_0000115 "A bistratified retinal ganglion cell that has a dendrite field that terminates in sublaminar layer S2 and a second dendrite field that terminates in sublaminar layer S4." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasExactSynonym "ON-OFF DS" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003010" ; a owl:Class ; rdfs:label "G7 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0003001, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0003011 obo:IAO_0000115 "A mono-stratified retinal ganglion cell that has a large dendritic field and a sparse dendritic arbor with post synaptic terminals in sublaminar layer S4." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003011" ; a owl:Class ; rdfs:label "G8 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0003012 obo:IAO_0000115 "A mono-stratified retinal ganglion cell that has a large dendritic field and a medium dendritic arbor with post synaptic terminals in sublaminar layer S1 and S2." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003012" ; a owl:Class ; rdfs:label "G9 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ] . obo:CL_0003013 obo:IAO_0000115 "A mono-stratified retinal ganglion cell that has a large dendritic field, a medium dendritic arbor, and a long secondary dendrite shaft with post synaptic terminals in sublaminar layer S4." ; oboInOwl:hasDbXref "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003013" ; a owl:Class ; rdfs:comment "Capable of ON directional sensitivity." ; rdfs:label "G10 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0003014 obo:IAO_0000115 "A mono-stratified retinal ganglion cell that has a large dendritic field, a medium dendritic arbor, and a medium length secondary dendrite shaft." ; oboInOwl:hasDbXref "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003014" ; a owl:Class ; rdfs:comment "Is capable of brisk transient currents." ; rdfs:label "G11 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ] . obo:CL_0003015 obo:IAO_0000115 "A G11 retinal ganglion cell that has post synaptic terminals in sublaminar layer S4 and is depolarized by illumination of its receptive field center." ; oboInOwl:hasDbXref "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003015" ; a owl:Class ; rdfs:label "G11-ON retinal ganglion cell" ; rdfs:subClassOf obo:CL_0003014, obo:CL_4023032, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0003016 obo:IAO_0000115 "A G11 retinal ganglion cell that has post synaptic terminals in sublaminar layer S2 and is depolarized by decreased illumination of their receptive field center" ; oboInOwl:hasDbXref "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003016" ; a owl:Class ; rdfs:label "G11-OFF retinal ganglion cell" ; rdfs:subClassOf obo:CL_0003014, obo:CL_4023033, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ] . obo:CL_0003017 obo:IAO_0000115 "A retinal ganglion B cell that has post synaptic terminals in S2." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003017" ; a owl:Class ; rdfs:label "retinal ganglion cell B3 outer" ; rdfs:subClassOf obo:CL_0004183, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ] . obo:CL_0003018 obo:IAO_0000115 "A retinal ganglion B3 cell with dentrites terminating in S4." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasDbXref "BAMS:1010" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003018" ; a owl:Class ; rdfs:label "retinal ganglion cell B3 inner" ; rdfs:subClassOf obo:CL_0004183, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0003020 obo:IAO_0000115 "A retinal ganglion cell C that has post-synaptic terminals in S2." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003020" ; a owl:Class ; rdfs:label "retinal ganglion cell C outer" ; rdfs:subClassOf obo:CL_0004116, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ] . obo:CL_0003021 obo:IAO_0000115 "A retinal ganglion cell C outer that has a medium dendritic field and a dense dendritic arbor." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003021" ; a owl:Class ; rdfs:label "retinal ganglion cell C4" ; rdfs:subClassOf obo:CL_0003020 . obo:CL_0003022 obo:IAO_0000115 "A retinal ganglion cell C outer that has medium dendritic density and field size." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003022" ; a owl:Class ; rdfs:label "retinal ganglion cell C5" ; rdfs:subClassOf obo:CL_0003020 . obo:CL_0003023 obo:IAO_0000115 "A retinal ganglion cell C outer that has dense dendritic diversity." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003023" ; a owl:Class ; rdfs:label "retinal ganglion cell C6" ; rdfs:subClassOf obo:CL_0003020 . obo:CL_0003024 obo:IAO_0000115 "A retinal ganglion cell C with medium cell bodies and large dendritic field." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003024" ; a owl:Class ; rdfs:label "retinal ganglion cell C inner" ; rdfs:subClassOf obo:CL_0004116, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0003025 obo:IAO_0000115 "A retinal ganglion cell C inner that has sparse dendritic density, and large dendritic field." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:hasRelatedSynonym "epsilon" ; oboInOwl:id "CL:0003025" ; a owl:Class ; rdfs:label "retinal ganglion cell C3" ; rdfs:subClassOf obo:CL_0003024 . obo:CL_0003026 obo:IAO_0000115 "A bistratified retinal ganglion cell that has a small dendrite fields with a sparse dendrite arbor terminating in S2 and S3." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003026" ; a owl:Class ; rdfs:label "retinal ganglion cell D1" ; rdfs:subClassOf obo:CL_0003001, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ] . obo:CL_0003027 obo:IAO_0000115 "A bistratified retinal ganglion cell D cell that has medium dendritic arbor and a large dendritic field that terminates in S2 and S4." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:hasRelatedSynonym "ON-OFF direction selective", "iota cell" ; oboInOwl:id "CL:0003027" ; a owl:Class ; rdfs:label "retinal ganglion cell D2" ; rdfs:subClassOf obo:CL_0003001, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0003028 obo:IAO_0000115 "A monostratified retinal ganglion cell that has a small dendrite field with a dense dendrite arbor with post synaptic terminals in sublaminer layer S4." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003028" ; a owl:Class ; rdfs:label "M1 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0003029 obo:IAO_0000115 "A monostratified retinal ganglion cell that has a small soma, a small dendrite field with a dense dendrite arbor, and post synaptic terminals in sublaminer layer S2 and S3." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003029" ; a owl:Class ; rdfs:label "M2 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ] . obo:CL_0003030 obo:IAO_0000115 "A monostratified retinal ganglion cell that has a medium soma and a small dendrite field." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003030" ; a owl:Class ; rdfs:label "M3 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ] . obo:CL_0003031 obo:IAO_0000115 "A monostratified retinal ganglion cell that has post synaptic terminals in sublaminar layer S4 and is depolarized by illumination of its receptive field center." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003031" ; a owl:Class ; rdfs:label "M3-ON retinal ganglion cell" ; rdfs:subClassOf obo:CL_0003030, obo:CL_4023032, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0003032 obo:IAO_0000115 "A monostratified retinal ganglion cell that has post synaptic terminals in sublaminar layer S2 and is depolarized by decreased illumination of their receptive field center" ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003032" ; a owl:Class ; rdfs:label "M3-OFF retinal ganglion cell" ; rdfs:subClassOf obo:CL_0003030, obo:CL_4023033, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ] . obo:CL_0003033 obo:IAO_0000115 "A monostratified retinal ganglion cell that has a large soma, a medium dendritic field with post synaptic terminals in sublaminar layer S3." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003033" ; a owl:Class ; rdfs:label "M4 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ] . obo:CL_0003034 obo:IAO_0000115 "A monostratified retinal ganglion cell that has a small soma, an assymetric dendritic field with post synaptic terminals in sublaminar layer S3." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003034" ; a owl:Class ; rdfs:label "M5 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ] . obo:CL_0003035 obo:IAO_0000115 "A monostratified retinal ganglion cell that contains opsin." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003035" ; a owl:Class ; rdfs:label "M6 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001243 ] . obo:CL_0003036 obo:IAO_0000115 "A monostratified retinal ganglion cell with large soma and large dendritic field, with medium dendritic arbor, and has dendrites in layers 2 and 5." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003036" ; a owl:Class ; rdfs:label "M7 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ] . obo:CL_0003037 obo:IAO_0000115 "An M7 retinal ganglion cells with synaptic terminals in S4 and is depolarized by illumination of its receptive field center." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003037" ; a owl:Class ; rdfs:label "M7-ON retinal ganglion cell" ; rdfs:subClassOf obo:CL_0003036, obo:CL_4023032, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0003038 obo:IAO_0000115 "An M7 retinal ganglion cells with synaptic terminals in S2 and is depolarized by decreased illumination of their receptive field center" ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003038" ; a owl:Class ; rdfs:label "M7-OFF retinal ganglion cell" ; rdfs:subClassOf obo:CL_0003036, obo:CL_4023033, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ] . obo:CL_0003039 obo:IAO_0000115 "A monostratified retinal ganglion cell with large soma and medium dendritic field, with dense dendritic arbor." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003039" ; a owl:Class ; rdfs:label "M8 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ] . obo:CL_0003040 obo:IAO_0000115 "A monostratified retinal ganglion cell with large soma and large dendritic field, with medium dendritic arbor, and has dendrites in layers 1 and 5." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003040" ; a owl:Class ; rdfs:label "M9 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ] . obo:CL_0003041 obo:IAO_0000115 "An M9 retinal ganglion cells with synaptic terminals in S2 and is depolarized by illumination of its receptive field center." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003041" ; a owl:Class ; rdfs:label "M9-ON retinal ganglion cell" ; rdfs:subClassOf obo:CL_0003040, obo:CL_4023032, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ] . obo:CL_0003042 obo:IAO_0000115 "An M9 retinal ganglion cell with synaptic terminals in S4 that is depolarized by decreased illumination of their receptive field center" ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003042" ; a owl:Class ; rdfs:label "M9-OFF retinal ganglion cell" ; rdfs:subClassOf obo:CL_0003040, obo:CL_4023033, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0003043 obo:IAO_0000115 "A monostratified retinal ganglion cell with large soma and large dendritic field, with dense dendritic arbor." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003043" ; a owl:Class ; rdfs:label "M10 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ] . obo:CL_0003044 obo:IAO_0000115 "A bistratified ganglion cell with small, dense dendritic fields that terminate in S1 and S3." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003044" ; a owl:Class ; rdfs:label "M11 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0003001, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ] . obo:CL_0003045 obo:IAO_0000115 "A bistratified ganglion cell with larger, asymetric dendritic fields that terminate in S2 and S4." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003045" ; a owl:Class ; rdfs:label "M12 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0003001, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0003046 obo:IAO_0000115 "A bistratifed retinal ganglion cell that has small, symmetric dendritic fields that terminate in S2 and S4." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003046" ; a owl:Class ; rdfs:label "M13 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0003001, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0003047 obo:IAO_0000115 "A bistratifed retinal ganglion cell that has small, symmetric dendritic fields that terminate in S1 and S4-S5." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003047" ; a owl:Class ; rdfs:label "M14 retinal ganglion cell" ; rdfs:subClassOf obo:CL_0003001, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008929 ] . obo:CL_0003048 obo:IAO_0000115 "A cone cell that detects long wavelength light. Exact peak of spectra detected differs between species. In humans, spectra peaks at 564-580 nm." ; terms:contributor "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasExactSynonym "L cone", "L-cone", "long wavelength sensitive cone", "long- (L) wavelength-sensitive cone", "long-wavelength cone" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003048" ; a owl:Class ; rdfs:label "L cone cell" ; rdfs:subClassOf obo:CL_0000573, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001244 ] . obo:CL_0003049 obo:IAO_0000115 "A cone cell that detects medium wavelength light. Exact peak of spectra detected differs between species. In humans, spectra peaks at 534-545 nm." ; terms:contributor "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasExactSynonym "M cone", "M-cone", "middle wavelength sensitive cone", "middle- (M) wavelength-sensitive cone", "middle-wavelength-sensitive (M) cone" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003049" ; a owl:Class ; rdfs:label "M cone cell" ; rdfs:subClassOf obo:CL_0000573, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001224 ] . obo:CL_0003050 obo:IAO_0000115 "A cone cell that detects short wavelength light. Exact peak of spectra detected differs between species. In humans, spectra peaks at 420-440 nm." ; terms:contributor "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasExactSynonym "S cone", "S-(short-wavelength sensitive) cone", "S-cone", "S-cone photoreceptor", "short wavelength sensitive cone", "short- (S) wavelength-sensitive cone", "short-wavelength sensitive cone", "short-wavelength-sensitive (S) cone" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003050" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "S cone cell" ; rdfs:subClassOf obo:CL_0000573 . obo:CL_0003051 obo:IAO_0000115 "A cone cell that detects ultraviolet (UV) wavelength light." ; terms:contributor "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0003051" ; a owl:Class ; rdfs:label "UV cone cell" ; rdfs:subClassOf obo:CL_0000573 . obo:CL_0004001 obo:IAO_0000115 "An interneuron whose axon stays entirely within the gray matter region where the cell body resides." ; oboInOwl:hasDbXref "BAMS:1002" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004001" ; a owl:Class ; rdfs:comment "Local interneurons form the category of interneurons whose axon stays entirely within the gray matter region where the cell body resides (Swanson, 2003, p. 245; Bota and Swanson, 2007, Fig. 3)." ; rdfs:label "local interneuron" ; rdfs:subClassOf obo:CL_0000099, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002020 ] . obo:CL_0004115 obo:IAO_0000115 "A monostratified retinal ganglion cell with small to medium soma and small to medium dendritic field." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004115" ; a owl:Class ; rdfs:label "retinal ganglion cell B" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ] . obo:CL_0004116 obo:IAO_0000115 "A retinal ganglion with cell medium cell bodies and medium to large dendritic fields." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004116" ; a owl:Class ; rdfs:comment "Group RGC cells are defined as having small to medium cell bodies and medium to large dendritic fields. Their morphology was more heterogeneous than that of Groups RGA and RGB. We classified cells with a large soma and a large dendritic field as RGA, cells with a small to medium to sized soma and a small to medium to sized dendritic field as RGB, and cells with a small to medium to sized soma but a medium to large dendritic field RGC." ; rdfs:label "retinal ganglion cell C" ; rdfs:subClassOf obo:CL_0000740 . obo:CL_0004117 obo:IAO_0000115 "A monostratified retinal ganglion cell with large soma and large dendritic field." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasDbXref "BAMS:1009" ; oboInOwl:hasExactSynonym "alpha cell" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004117" ; a owl:Class ; rdfs:comment "This group includes all of the large bodied/large field RGCs in the rat. Group RGA cells have large somata (15 to 39 micrometers in diameter) and large, radially branching dendritic fields (235 to 748 micrometers in diameter), and many exhibit tracer coupling." ; rdfs:label "retinal ganglion cell A" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ] . obo:CL_0004119 obo:IAO_0000115 "A retinal ganglion cell B that has medium body size, medium dendritic field and dense dendritic arbor, and has post synaptic terminals in S2." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasDbXref "BAMS:1047" ; oboInOwl:hasExactSynonym "retinal ganglion cell B4" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004119" ; a owl:Class ; rdfs:comment "Could not distingush between B1 and B4 from paper." ; rdfs:label "retinal ganglion cell B1" ; rdfs:subClassOf obo:CL_0004115, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ] . obo:CL_0004120 obo:IAO_0000115 "A retinal ganglion A cell found in the retina with large somata, often polygonal in shape. The dendritic fields consist of three to seven stout dendrites that are sparce near soma. Dendrites terminate in S4." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasBroadSynonym "type I" ; oboInOwl:hasDbXref "BAMS:1045" ; oboInOwl:hasExactSynonym "inner alpha retinal ganglion cell" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:hasRelatedSynonym "I-2" ; oboInOwl:id "CL:0004120" ; a owl:Class ; rdfs:label "retinal ganglion cell A1" ; rdfs:subClassOf obo:CL_0004117, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0004121 obo:IAO_0000115 "A retinal ganglion cell B that has a very small but very dense dendritic field, and has post synaptic terminals in S2." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasDbXref "BAMS:1048" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004121" ; a owl:Class ; rdfs:label "retinal ganglion cell B2" ; rdfs:subClassOf obo:CL_0004115, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ] . obo:CL_0004124 obo:IAO_0000115 "A retinal ganglion cell C inner that has medium dendritic diversity." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasDbXref "BAMS:1050" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:hasRelatedSynonym "MTN projecting", "ON-direction-selective", "delta" ; oboInOwl:id "CL:0004124" ; a owl:Class ; rdfs:label "retinal ganglion cell C1" ; rdfs:subClassOf obo:CL_0003024 . obo:CL_0004125 obo:IAO_0000115 "A retinal ganglion cell C inner that has dense dendritic diversity." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasDbXref "BAMS:1067" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004125" ; a owl:Class ; rdfs:label "retinal ganglion cell C2 inner" ; rdfs:subClassOf obo:CL_0003024 . obo:CL_0004126 obo:IAO_0000115 "A retinal ganglion cell C outer that has symmetrical and dense dendritic dendritic tree with a large dendritic field." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasDbXref "BAMS:1066" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004126" ; a owl:Class ; rdfs:label "retinal ganglion cell C2 outer" ; rdfs:subClassOf obo:CL_0003020 . obo:CL_0004137 obo:IAO_0000115 "A retinal ganglion A2 cell with dendrites terminating in S4." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasDbXref "BAMS:1061" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004137" ; a owl:Class ; rdfs:label "retinal ganglion cell A2 inner" ; rdfs:subClassOf obo:CL_0004138, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0004138 obo:IAO_0000115 "A retinal ganglion A cell with dense arbor near soma." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasExactSynonym "outer alpha retinal ganglion cell" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:hasRelatedSynonym "I-1", "type I" ; oboInOwl:id "CL:0004138" ; a owl:Class ; rdfs:label "retinal ganglion cell A2" ; rdfs:subClassOf obo:CL_0004117 . obo:CL_0004139 obo:IAO_0000115 "A retinal ganglion A2 cell with dendrites terminating in S2." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasDbXref "BAMS:1065" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004139" ; a owl:Class ; rdfs:label "retinal ganglion cell A2 outer" ; rdfs:subClassOf obo:CL_0004138, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ] . obo:CL_0004161 obo:IAO_0000115 "A cone whose sensitivity measurements have an average spectral peak of 510 nm. These cones are described in rat." ; obo:RO_0002175 obo:NCBITaxon_9989 ; terms:contributor "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasDbXref "BAMS:1028" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004161" ; a owl:Class ; rdfs:label "510 nm-cone" ; rdfs:subClassOf obo:CL_0003049 . obo:CL_0004162 obo:IAO_0000115 "A cone whose sensitivity measurements have an average spectral peak of 358.2 nm. These cones are described in rat." ; obo:RO_0002175 obo:NCBITaxon_9989 ; terms:contributor "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasDbXref "BAMS:1029" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004162" ; a owl:Class ; rdfs:comment "The photopigment curves that provide best fits to...sensitivity measurements have an average spectral peak of 358.2 nm." ; rdfs:label "360 nm-cone" ; rdfs:subClassOf obo:CL_0003051 . obo:CL_0004183 obo:IAO_0000115 "A monostratified retinal ganglion cell with medium soma, sparse dendritic tree, and medium dendritic field." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasDbXref "BAMS:1049" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004183" ; a owl:Class ; rdfs:comment "Sixty to eighty neurons with small somata (12 to 24 micrometers in diameter), small dendritic fields (99 to 289 micrometers in diameter), and small axonal diameters (04. to 07. micrometers in diameter) make up Group RGB. We classified cells with a large soma and a large dendritic field as RGA, cells with a small to medium to sized soma and a small to medium to sized dendritic field as RGB, and cells with a small to medium to sized soma but a medium to large dendritic field RGC." ; rdfs:label "retinal ganglion cell B3" ; rdfs:subClassOf obo:CL_0004115 . obo:CL_0004213 obo:IAO_0000115 "A type of type 3 cone bipolar cell with distinctive curly dendrites." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004213" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type 3a cone bipolar cell" ; rdfs:subClassOf obo:CL_0000755, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0030425 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000405 ] ) ] ] . obo:CL_0004214 obo:IAO_0000115 "A type of type 3 cone bipolar cell with distinctive crescent-shaped dendrites." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004214" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type 3b cone bipolar cell" ; rdfs:subClassOf obo:CL_0000755, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0030425 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001870 ] ) ] ] . obo:CL_0004215 obo:IAO_0000115 "A type 5 cone bipolar cell with narrowly stratified post synaptic terminals." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004215" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type 5a cone bipolar cell" ; rdfs:subClassOf obo:CL_0000757 . obo:CL_0004216 obo:IAO_0000115 "A type 5 cone bipolar cell with diffuse axonal branches." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004216" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "type 5b cone bipolar cell" ; rdfs:subClassOf obo:CL_0000757 . obo:CL_0004217 obo:IAO_0000115 "A horizontal cell with a large cell body, thick dendrites, and a large dendritic arbor." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasExactSynonym "A Horizontal Cell" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:hasRelatedSynonym "H1" ; oboInOwl:id "CL:0004217" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "H1 horizontal cell" ; rdfs:subClassOf obo:CL_0000745, [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0030424 ] . obo:CL_0004218 obo:IAO_0000115 "A horizontal cell with a small cell body, thin dendrites, and small dendritic arbor." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasExactSynonym "B Horizontal Cell" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:hasRelatedSynonym "H2" ; oboInOwl:id "CL:0004218" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "H2 horizontal cell" ; rdfs:subClassOf obo:CL_0000745, [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:GO_0044316 ] . obo:CL_0004219 obo:IAO_0000115 "A bistratifed retinal amacrine cell with a small dendritic field, dendrite stratification in S1-S2, and a second dendrite stratification in S5. This cell type releases the neurotransmitter glycine." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004219" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "A2 amacrine cell" ; rdfs:subClassOf obo:CL_0004250, obo:CL_0004251, obo:CL_4030028, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008926 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008927 ] . obo:CL_0004220 obo:IAO_0000115 "An amacrine cell with a small, asymteric dendritic field." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004220" ; a owl:Class ; rdfs:label "flag amacrine cell" ; rdfs:subClassOf obo:CL_0004251 . obo:CL_0004221 obo:IAO_0000115 "A flag amacrine cell with post-synaptic terminals in S2 and S3. This cell type releases the neurotransmitter glycine." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004221" ; a owl:Class ; rdfs:label "flag A amacrine cell" ; rdfs:subClassOf obo:CL_0004220, obo:CL_4030028, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ] . obo:CL_0004222 obo:IAO_0000115 "A flag amacrine cell with post-synaptic terminals in S3, S4, and S5. This cell type releases the neurotransmitter glycine." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004222" ; a owl:Class ; rdfs:label "flag B amacrine cell" ; rdfs:subClassOf obo:CL_0004220, obo:CL_4030028, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008926 ] . obo:CL_0004223 obo:IAO_0000115 "A amacrine cell with a small dendritic field and post-synaptic terminals in S1, S2, S3, and S4. AB diffuse-1 amacrine cells have a tent-shaped dendritic arbor and undulate dendrites." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004223" ; a owl:Class ; rdfs:label "AB diffuse-1 amacrine cell" ; rdfs:subClassOf obo:CL_0004251, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0004224 obo:IAO_0000115 "A broadly stratifying amacrine cell that has a small dendritic field and post-synaptic terminals in S2 and S3. This cell type releases the neurotransmitter glycine." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004224" ; a owl:Class ; rdfs:label "AB diffuse-2 amacrine cell" ; rdfs:subClassOf obo:CL_0004251, obo:CL_4030028, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ] . obo:CL_0004225 obo:IAO_0000115 "A broadly stratifying amacrine cell with a small dendritic field, straight dendrites and post-synaptic terminals in S1, S2, and S3." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004225" ; a owl:Class ; rdfs:label "spider amacrine cell" ; rdfs:subClassOf obo:CL_0004251, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ] . obo:CL_0004226 obo:IAO_0000115 "An amacrine cell with a small dendritic field with post-synaptic terminals in S3 and S4." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004226" ; a owl:Class ; rdfs:label "monostratified amacrine cell" ; rdfs:subClassOf obo:CL_0004246, obo:CL_0004251, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0004251 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ] ) ] . obo:CL_0004227 obo:IAO_0000115 "A bistratified amacrine cell with a small dendritic field. Flat bistratified amacrine cells have post-synaptic terminals both on the border of S1 and S2, and on the border of S3 and S4. This cell type releases the neurotransmitter glycine." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004227" ; a owl:Class ; rdfs:label "flat bistratified amacrine cell" ; rdfs:subClassOf obo:CL_0004250, obo:CL_0004251, obo:CL_4030028, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0009738 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0009739 ] . obo:CL_0004228 obo:IAO_0000115 "An amacrine cell with a small dendritic field that has post-synaptic terminals in S1, S2, S3, and S4." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004228" ; a owl:Class ; rdfs:label "broad diffuse amacrine cell" ; rdfs:subClassOf obo:CL_0004251, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0004229 obo:IAO_0000115 "A bistratified amacrine cell with a small dendritic field that has dendrite stratification in S2, and in S3 and S4." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004229" ; a owl:Class ; rdfs:label "A2-like amacrine cell" ; rdfs:subClassOf obo:CL_0004250, obo:CL_0004251, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0009731 ] . obo:CL_0004230 obo:IAO_0000115 "A bistratified amacrine cell with a small dendritic field that has post-synaptic terminals in S1 and the border of S1-S2, and termination of a second arbor within the border of S2-S3 and S3." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004230" ; a owl:Class ; rdfs:label "diffuse bistratified amacrine cell" ; rdfs:subClassOf obo:CL_0004250, obo:CL_0004251, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0009738 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0009852 ] . obo:CL_0004231 obo:IAO_0000115 "A broadly stratifying amacrine cell with a small dendritic field and a complex dendritic arbor. Recurving diffuse amacrine cells have post-synaptic terminals in S2, S3, and S4." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004231" ; a owl:Class ; rdfs:label "recurving diffuse amacrine cell" ; rdfs:subClassOf obo:CL_0004251, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0004232 obo:IAO_0000115 "An amacrine cell with a flat dendritic arbor and a medium dendritic field. Starburst amacrine cells have post-synaptic terminals in S2. This cell type releases the neurotransmitters gamma-aminobutyric acid (GABA) and acetylcholine." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004232" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "starburst amacrine cell" ; rdfs:subClassOf obo:CL_0008061, obo:CL_4030027, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ] . obo:CL_0004233 obo:IAO_0000115 "An amacrine cell with a medium dendritic field and post-synaptic terminals that stratify at S2, with a second stratification that occurs in S3 and S4. This cell type releases the neurotransmitter glycine." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004233" ; a owl:Class ; rdfs:label "DAPI-3 amacrine cell" ; rdfs:subClassOf obo:CL_0004250, obo:CL_0004252, obo:CL_4030028, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0009731 ] . obo:CL_0004234 obo:IAO_0000115 "An amacrine cell with a medium dendritic field and post-synaptic terminals in S2, and in S3-S4." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004234" ; a owl:Class ; rdfs:label "diffuse multistratified amacrine cell" ; rdfs:subClassOf obo:CL_0004252, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0009731 ] . obo:CL_0004235 obo:IAO_0000115 "An amacrine cell with a medium dendritic field and post-synaptic terminals in S2 and S3. This cell type releases the neurotransmitter gamma-aminobutyric acid (GABA)." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004235" ; a owl:Class ; rdfs:label "AB broad diffuse-1 amacrine cell" ; rdfs:subClassOf obo:CL_0004252, obo:CL_4030027, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ] . obo:CL_0004236 obo:IAO_0000115 "An amacrine cell with a medium dendritic field and post-synaptic terminals in S2, S3, and S4. This cell type releases the neurotransmitter gamma-aminobutyric acid (GABA)." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004236" ; a owl:Class ; rdfs:label "AB broad diffuse-2 amacrine cell" ; rdfs:subClassOf obo:CL_0004252, obo:CL_4030027, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0004237 obo:IAO_0000115 "A retinal amacrine cell with a medium dendritic field and post-synaptic terminals in S1, S2, S3, and S4. This cell type releases the neurotransmitter gamma-aminobutyric acid (GABA)." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004237" ; a owl:Class ; rdfs:label "fountain amacrine cell" ; rdfs:subClassOf obo:CL_0004252, obo:CL_4030027, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0004238 obo:IAO_0000115 "A bistratified amacrine cell with a medium dendritic field, a flat and sparse dendritic arbor, and post-synaptic terminals at the intersections of S1 and S2, and S3 and S4." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004238" ; a owl:Class ; rdfs:label "asymmetric bistratified amacrine cell" ; rdfs:subClassOf obo:CL_0004250, obo:CL_0004252, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0009738 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0009739 ] . obo:CL_0004239 obo:IAO_0000115 "A bistratified amacrine cell with a medium dendritic field and post-synaptic terminals in S1-S2, and S4." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004239" ; a owl:Class ; rdfs:label "wavy bistratified amacrine cell" ; rdfs:subClassOf obo:CL_0004250, obo:CL_0004252, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0004240 obo:IAO_0000115 "An amacrine cell with a wide dendritic field, dendrites in S1, and post-synaptic terminals in S1." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004240" ; a owl:Class ; rdfs:label "WF1 amacrine cell" ; rdfs:subClassOf obo:CL_0004253, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008922 ] . obo:CL_0004241 obo:IAO_0000115 "An amacrine cell with a wide dendritic field, dendrites in S2, and post-synaptic terminals in S1." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004241" ; a owl:Class ; rdfs:label "WF2 amacrine cell" ; rdfs:subClassOf obo:CL_0004253, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008922 ] . obo:CL_0004242 obo:IAO_0000115 "An amacrine cell with a wide dendritic field, dendrites in S3, and post-synaptic terminals in S3. Dendrites of this cell type are straight and minimally branched." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004242" ; a owl:Class ; rdfs:label "WF3-1 amacrine cell" ; rdfs:subClassOf obo:CL_0004253, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ] . obo:CL_0004243 obo:IAO_0000115 "An amacrine cell with a wild dendritic field, dendrites in S3, and post-synaptic terminals in S3. Dendrites have spikes, cross over each other, and cover a larger volume than dendrties of W3-1 retinal amacrine cells." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004243" ; a owl:Class ; rdfs:label "WF3-2 amacrine cell" ; rdfs:subClassOf obo:CL_0004253, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008924 ] . obo:CL_0004244 obo:IAO_0000115 "An amacrine cell with a wide dendritic field, dendrites in S4, and post-synaptic terminals in S4." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004244" ; a owl:Class ; rdfs:label "WF4 amacrine cell" ; rdfs:subClassOf obo:CL_0004253, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008925 ] . obo:CL_0004245 obo:IAO_0000115 "An amacrine cell with a wide dendritic field and post-synaptic terminals in S5. This cell type releases the neurotransmitters gamma-aminobutyric acid (GABA) and serotonin." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004245" ; a owl:Class ; rdfs:label "indoleamine-accumulating amacrine cell" ; rdfs:subClassOf obo:CL_0000850, obo:CL_0004253, obo:CL_4030027, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0008926 ] . obo:CL_0004246 obo:IAO_0000115 "A central nervous system neuron that stratifies at one and only one location." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004246" ; a owl:Class ; rdfs:label "monostratified cell" ; rdfs:subClassOf obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070063 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] . obo:CL_0004247 obo:IAO_0000115 "A neuron that stratifies dendrites at two and only two locations." ; terms:contributor "https://orcid.org/0000-0001-7258-9596" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004247" ; a owl:Class ; rdfs:label "bistratified cell" ; rdfs:subClassOf obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070062 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070062 ] ) ] . obo:CL_0004250 obo:IAO_0000115 "An amicrine that stratifies dendrites at two and only two locations." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004250" ; a owl:Class ; rdfs:label "bistratified retinal amacrine cell" ; rdfs:subClassOf obo:CL_0000561, obo:CL_0004247 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000561 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070062 ] ) ] . obo:CL_0004251 obo:IAO_0000115 "An amicrine that has a narrow dendritic field." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004251" ; a owl:Class ; rdfs:label "narrow field retinal amacrine cell" ; rdfs:subClassOf obo:CL_0000561 . obo:CL_0004252 obo:IAO_0000115 "An amicrine that has a medium dendritic field." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004252" ; a owl:Class ; rdfs:label "medium field retinal amacrine cell" ; rdfs:subClassOf obo:CL_0000561 . obo:CL_0004253 obo:IAO_0000115 "An amicrine that has a wide dendritic field." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-5260-9315" ; oboInOwl:hasOBONamespace "cell" ; oboInOwl:id "CL:0004253" ; a owl:Class ; rdfs:label "wide field retinal amacrine cell" ; rdfs:subClassOf obo:CL_0000561 . obo:CL_0005000 obo:IAO_0000115 "A CNS interneuron located in the spinal cord." ; oboInOwl:hasDbXref "ZFA:0000778" ; a owl:Class ; rdfs:comment "Is_a interneuron, part_of UBERON:0002240." ; rdfs:label "spinal cord interneuron" ; rdfs:subClassOf obo:CL_0000099, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002240 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] ; skos:prefLabel "spinal cord interneuron" . obo:CL_0005001 obo:IAO_0000115 "A non-terminally differentiated cell that originates from the neural crest and differentiates into an iridophore." ; oboInOwl:hasDbXref "ZFA:0005328" ; a owl:Class ; rdfs:comment "Derived from UBERON:0002342 neural crest." ; rdfs:label "iridoblast" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] . obo:CL_0005002 obo:IAO_0000115 "A non-terminally differentiated cell that differentiates into a xanthophore." ; oboInOwl:hasDbXref "ZFA:0005245" ; a owl:Class ; rdfs:label "xanthoblast" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] . obo:CL_0005003 obo:IAO_0000115 "A non-terminally differentiated cell that originates from the neural crest and differentiates into a leucophore." ; oboInOwl:hasDbXref "ZFA:0005329" ; a owl:Class ; rdfs:label "leucoblast" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] . obo:CL_0005004 obo:IAO_0000115 "A non-terminally differentiated cell that originates from the neural crest and differentiates into an erythrophore." ; oboInOwl:hasDbXref "ZFA:0005331" ; a owl:Class ; rdfs:label "pigment erythroblast" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] . obo:CL_0005005 obo:IAO_0000115 "A non-terminally differentiated cell that originates from the neural crest and differentiates into a cyanophore." ; oboInOwl:hasDbXref "ZFA:0005332" ; a owl:Class ; rdfs:label "cyanoblast" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] . obo:CL_0005006 obo:IAO_0000115 "Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Ionocytes are specialized cells predominantly found in the mammalian respiratory and renal systems as well as in the gills, skin, and intestinal tract of fish. These cells play crucial roles in maintaining ion and acid-base homeostasis. Ionocytes demonstrate remarkable plasticity and are able to adapt themselves in response to changes in environmental conditions such as pH, salinity, ion concentration, and temperature. These cells work by selectively absorbing specific ions from the environment, thus maintaining the body's internal ionic balance. The most commonly absorbed ions include sodium (Na+), chloride (Cl-), calcium (Ca2+), and hydrogen (H+). Moreover, ionocytes contribute to acid-base regulation. In response to acidosis or alkalosis, ionocytes can either excrete or retain hydrogen (H+) and bicarbonate (HCO3-) ions to readjust the blood pH. Further, experimental evidence suggests a functional complexity of ionocytes, implying diverse roles beyond ion regulation. Recent research highlights ionocytes' involvement in ammonia excretion and the regulation of extracellular fluid volume, highlighting their contribution to the overall homeostatic process. Malfunctioning ionocytes have been implicated in various diseases, including cystic fibrosis which is caused by mutations in the chloride channel CFTR, an ionocyte marker. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "ZFA:0005323" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "ionocyte" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005006" ; rdfs:subClassOf obo:CL_0000066 . obo:CL_0005007 obo:IAO_0000115 "Kolmer-Agduhr neurons are ciliated GABAergic neurons that contact the central canal of the spinal cord and have ipsilateral ascending axons." ; oboInOwl:hasDbXref "ZFA:0005240" ; oboInOwl:hasExactSynonym "KA cell", "KA interneuron", "KA neuron", "Kolmer-Agduhr cell" ; a owl:Class ; rdfs:label "Kolmer-Agduhr neuron" ; rdfs:subClassOf obo:CL_0005000, obo:CL_0011005 . obo:CL_0005008 obo:IAO_0000115 "An auditory hair cell located in the macula that is sensitive to auditory stimuli." ; a owl:Class ; rdfs:label "macular hair cell" ; rdfs:subClassOf obo:CL_0000202, obo:CL_0002374, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000054 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000202 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000054 ] ) ] . obo:CL_0005009 obo:IAO_0000115 "A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the apical membrane of the cell is regulated by aldosterone and vasopressin. In mammals this cell type is located in the renal collecting duct system." ; terms:description """Renal principal cells are the major cell type in the initial collecting tubule and the cortical and outer medullary collecting ducts, as well as the connecting tubule, in the nephrons of the kidneys. A key function of renal principal cells is the regulation of water balance in the body. These cells express aquaporin-2 (AQP2) water channels, which facilitate the reabsorption of water from the fluid within the renal tubule lumen back into the blood. The translocation of AQP2 to the cell membrane is controlled by the hormone vasopressin: In response to high vasopressin levels, AQP2 moves to the cell membrane, allowing water to pass through effectively and be reabsorbed, therefore concentrating the urine. Conversely, in low vasopressin conditions, AQP2 is removed from the membrane, reducing water reabsorption and diluting the urine. Renal principal cells are also involved in the regulation of sodium and potassium levels in the body. They have sodium channels (ENaC) in their luminal membranes which permit the reabsorption of sodium ions from the tubule fluid back into the blood, resulting in a net reabsorption of sodium ions into the systemic circulation. This process is controlled, in part, by the hormone aldosterone. Additionally, renal principal cells contain potassium channels that facilitate the secretion of potassium ions into the urine. The activities of these channels, in coordination with other cell types in the nephron, are critical for maintaining electrolyte balance and overall body homeostasis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "ZFA:0005322" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "renal principal cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005009" ; rdfs:subClassOf obo:CL_0000075, obo:CL_0002518 . obo:CL_0005010 obo:IAO_0000115 "A cuboidal epithelial cell of the kidney that regulates acid/base balance." ; terms:description """Renal intercalated cells are specialized cells located in the collecting duct system of the kidneys. The primary role of intercalated cells is to reabsorb bicarbonate ions and secrete hydrogen ions, thereby maintaining the acid-base homeostasis in the blood. They comprise two main subtypes primarily distinguished by their functional and morphological attributes: alpha and beta intercalated cells. Alpha intercalated cells are more predominant when the body is in a state of acidosis, a condition characterized by an increased acidity of the blood. These cells are specialized in secreting excessive hydrogen ions into the urine through a mechanism involving vacuolar H+-ATPase and H+/K+-ATPase pumps on their apical membranes. They simultaneously reabsorb bicarbonate ions from the tubular fluid and return them to the bloodstream via mechanisms involving carbonic anhydrase II and bicarbonate/chloride exchangers on the basolateral membrane. This dual process helps to increase blood pH towards normal levels. When the body is in a state of alkalosis, a condition characterized by lowered levels of hydrogen ions in the blood, beta intercalated cells are more predominant. They primarily reabsorb hydrogen ions from the tubular fluid through vacuolar H+-ATPase and H+/K+-ATPase pumps on their basolateral membranes, while secreting bicarbonate ions into the urine via pendrin, a bicarbonate/chloride exchanger in the apical membrane. These mechanisms work together to decrease blood pH towards normal levels. In summary, renal intercalated cells play a critical role in the delicate balance of the body’s pH, safeguarding the body from potential harm caused by acidemia or alkalemia. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:86560", "ZFA:0009375" ; oboInOwl:hasExactSynonym "intercalated cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Intercalated cells are also called “mitochondria-rich cells”, reflecting the high levels of round mitochondria at their apical pole, or in their cytoplasm, a distribution that is quite different from that of other kidney tubule cells, which accumulated mitochondria around the basolateral membrane. These cells also have numerous irregular apical microvilli compared with the surrounding segment-specific cells. Intercalated cells lack a central cilium, at least in the cortex, which also differentiates them from the adjacent principal cells." ; rdfs:label "renal intercalated cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005010" ; rdfs:subClassOf obo:CL_0000075, obo:CL_0002078, obo:CL_1000449 . obo:CL_0005011 obo:IAO_0000115 "A cuboidal epithelial cell of the kidney which secretes acid and reabsorbs base to regulate acid/base balance." ; terms:description """Renal alpha-intercalated cells are located within the connecting tubules and collecting ducts of the kidneys, which are components of the kidney's complex nephron system. Along with beta-intercalated cells, they play a critical role in the body’s acid-base balance. Renal alpha-intercalated cells contain an abundance of proton pumps and enzymes like carbonic anhydrase, which aid in the transport of hydrogen ions for secretion in the urine. The bicarbonate/chloride transporters on their apical membrane meanwhile take up bicarbonate ions from the urine and supply them back into the blood. Through this mechanism, these cells contribute significantly to the neutrality of blood pH, and dysfunction of renal alpha-intercalated cells often leads to distal renal tubular acidosis, a condition resulting in acidic blood and alkaline urine. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "ZFA:0009376" ; oboInOwl:hasExactSynonym "type A intercalated cell", "type A-IC" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Type A intercalated cells are the more abundant type of intercalated cell in the outer stripe of the outer medulla in most mammalian species." ; rdfs:label "renal alpha-intercalated cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005011" ; rdfs:subClassOf obo:CL_0005010, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0046717 ] . obo:CL_0005012 obo:IAO_0000115 "A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface." ; terms:description """The multi-ciliated epithelial cell are terminally differentiated epithelia that line brain ventricles, the respiratory tract and parts of the female and male reproductive organs in animals, playing critical roles in the maintenance of homeostasis through ciliary motion. They are characterized by the presence of hundreds of motile cilia, hair-like microtubule-based organelles that beat in a coordinated fashion to direct fluid flow over the cell surface. Multi-ciliated epithelial cells have fundamental roles in the proper functioning of many organ systems. In the respiratory system, they line the airways and orchestrate the coordinated movement of mucus, effectively clearing the airways of inhaled particles and pathogens. These cells are also vital in the ventricular system of the brain where they facilitate cerebrospinal fluid circulation, thus contributing to the maintenance of the brain's microenvironment. In the fallopian tube, multi-ciliated epithelial cells aid in the transport of oocytes from the ovary to the uterus, a process crucial to reproduction. The formation and function of multi-ciliated epithelial cells is a highly regulated process that involves several stages of development including cell specification, centriole multiplication, and ciliogenesis. Any disruption in these processes can result in dysfunctional or decreased numbers of cilia, which can lead to a myriad of health issues, ranging from chronic respiratory infections to infertility. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasBroadSynonym "multi-ciliated cell"@en, "multiciliated cell"@en ; oboInOwl:hasDbXref "ZFA:0005242" ; oboInOwl:hasExactSynonym "multi-ciliated epithelial cell", "multiciliated epithelial cell"@en ; oboInOwl:hasRelatedSynonym "MCC"@en ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "While the term 'multi-ciliated epithelial cell' refers to cells with multiple motile cilia, there are exceptions where epithelial cells may have multiple non-motile cilia. Examples include olfactory sensory neurons, which have non-motile cilia for sensory detection, and choroid plexus epithelial cells, which possess multiple non-motile cilia with transient motility during development. Multiciliated cells are essential for human health, and their dysfunction can lead to various diseases known as ciliopathies, such as primary ciliary dyskinesia. This condition affects the respiratory system, brain ventricles, and reproductive system, leading to chronic respiratory infections, hydrocephalus, and infertility" ; rdfs:label "multiciliated epithelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005012" ; rdfs:subClassOf obo:CL_0000067, obo:CL_0000075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0031514 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0010007 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0031514 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0010007 ] ) ] . obo:CL_0005013 obo:IAO_0000115 "A ciliated epithelial cell with a single cilium." ; oboInOwl:hasDbXref "ZFA:0005243" ; a owl:Class ; rdfs:label "single ciliated epithelial cell" ; rdfs:subClassOf obo:CL_0000067 . obo:CL_0005014 obo:IAO_0000115 "A non-sensory cell that extends from the basement membrane to the apical surface of the auditory epithelium and provides support for auditory hair cells." ; oboInOwl:hasDbXref "ZFA:0005244" ; oboInOwl:hasExactSynonym "auditory epithelial support cell" ; a owl:Class ; rdfs:label "auditory epithelial supporting cell" ; rdfs:subClassOf obo:CL_0000630, obo:CL_0000710, obo:CL_0002491 . obo:CL_0005015 obo:IAO_0000115 "An auditory epithelial support cell that surrounds the nerve fibers and synapses of the auditory inner hair cells." ; oboInOwl:hasDbXref "FMA:79801" ; a owl:Class ; rdfs:label "inner phalangeal cell" ; rdfs:subClassOf obo:CL_0002165 . obo:CL_0005016 obo:IAO_0000115 "Obsolete. Use PO:0030007 from Plant Ontology instead. The apical cell is the upper cell formed after the first division of a plant zygote." ; obo:IAO_0100001 obo:PO_0030007 ; a owl:Class ; rdfs:label "obsolete apical cell" ; owl:deprecated true . obo:CL_0005017 obo:IAO_0000115 "Obsolete. Use PO:0002002 from Plant Ontology instead. The lower cell formed after the first division of a plant zygote." ; obo:IAO_0100001 obo:PO_0002002 ; a owl:Class ; rdfs:label "obsolete plant basal cell" ; owl:deprecated true . obo:CL_0005018 obo:IAO_0000115 "A cell that secretes ghrelin, the peptide hormone that stimulates hunger." ; oboInOwl:hasDbXref "ZFA:0005599" ; a owl:Class ; rdfs:label "ghrelin secreting cell" ; rdfs:subClassOf obo:CL_0000167, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0036321 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0036321 ] ) ] . obo:CL_0005019 obo:IAO_0000115 "Ghrelin secreting cells found in the endocrine pancreas." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Pancreatic epsilon cells are a specialized type of endocrine cell found in the islets of Langerhans, a region of the pancreas responsible for hormone production. These clusters of cells constitute only about 1% of the pancreatic islet cell population, making them a relatively small yet significant component of the pancreas. Pancreatic epsilon cells have a round or ovoid shape with occasional cytoplasmic extensions and are characterized by small and spherical granules. The principal function of pancreatic epsilon cells involves the synthesis and release of the hormone ghrelin, a peptide hormone predominantly produced in the stomach; pancreatic epsilon cells are one of the few sites outside the gastrointestinal tract known to produce this hormone. Ghrelin has multiple vital roles, playing a significant part in generating hunger sensations, promoting fat storage, and influencing various metabolic processes. It also stimulates the release of Growth Hormone (GH) from the anterior pituitary gland. During fetal development, when they form a layer around the islet, epsilon cells are an important source of ghrelin, likely secreting the hormone into the circulation; their numbers decrease in adults. While research on pancreatic epsilon cells is still ongoing, these cells have been implicated in several disease states, most notably Type 2 diabetes and metabolic syndrome. The dysfunction or reduction in the number of pancreatic epsilon cells can lead to anomalies in ghrelin production, impacting overall metabolic homeostasis and glucose regulation. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "ZFA:0005598" ; oboInOwl:hasExactSynonym "pancreatic E cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "In mammals the endocrine pancreas is called the Islets of Langerhans." ; rdfs:label "pancreatic epsilon cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005019" ; rdfs:subClassOf obo:CL_0005018, obo:CL_0008024 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0008024 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0036321 ] ) ] . obo:CL_0005020 obo:IAO_0000115 "Lymphatic progenitor cells." ; terms:contributor ; oboInOwl:creation_date "2012-01-12T04:44:34Z"^^xsd:dateTime ; oboInOwl:hasDbXref "ZFA:0009393" ; a owl:Class ; rdfs:comment "Usually express Prox1, or prox1b." ; rdfs:label "lymphangioblast" ; rdfs:subClassOf obo:CL_0000048, obo:CL_4033054, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004536 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000048 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004536 ] ) ] . obo:CL_0005021 obo:IAO_0000115 "Mesenchymal derived lymphatic progenitor cells that give rise to the superficial lymphatics." ; terms:contributor ; oboInOwl:creation_date "2012-01-12T05:01:22Z"^^xsd:dateTime ; oboInOwl:hasDbXref "ZFA:0009394" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "mesenchymal lymphangioblast" ; rdfs:subClassOf obo:CL_0000134, obo:CL_0005020 . obo:CL_0005022 obo:IAO_0000115 "Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells." ; terms:contributor ; oboInOwl:creation_date "2012-01-12T05:21:09Z"^^xsd:dateTime ; oboInOwl:hasDbXref "ZFA:0009395" ; oboInOwl:hasNarrowSynonym "parachordal lymphangioblast" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "vascular lymphangioblast" ; rdfs:subClassOf obo:CL_0005020, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001638 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005020 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001638 ] ) ] . obo:CL_0005023 obo:IAO_0000115 "Cranial motor neuron which innervates muscles derived from the branchial (pharyngeal) arches." ; oboInOwl:hasDbXref "PMID:14699587", "ZFA:0005731" ; oboInOwl:hasExactSynonym "branchi motor neuron", "special visceral motor neuron" ; a owl:Class ; rdfs:label "branchiomotor neuron"@en ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0015000, [ a owl:Restriction ; owl:onProperty obo:RO_0002130 ; owl:someValuesFrom obo:UBERON_0004164 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0015000 [ a owl:Restriction ; owl:onProperty obo:RO_0002130 ; owl:someValuesFrom obo:UBERON_0004164 ] ) ] . obo:CL_0005024 obo:IAO_0000115 "A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic." ; oboInOwl:hasDbXref "ZFA:0005733" ; oboInOwl:hasExactSynonym "somatic motor neuron" ; a owl:Class ; rdfs:label "somatomotor neuron"@en ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000100, obo:CL_0000108, [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_0008002 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000100 [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_0008002 ] ) ] . obo:CL_0005025 obo:IAO_0000115 "A motor neuron that synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles and glands of the pulmonary, cardiovascular, and gastrointestinal systems." ; oboInOwl:hasDbXref "ZFA:0005732" ; oboInOwl:hasExactSynonym "general visceral motor neuron" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Note that these neurons do not synapse directly onto muscles" ; rdfs:label "visceromotor neuron"@en ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000100, [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_0011102 ] . obo:CL_0005026 obo:IAO_0000115 "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation." ; terms:description """Hepatoblasts are immature precursor cells that predominate during the early stages of liver development, specifically in the embryonic phase of life. They first arise from the endoderm, one of the three primary germ layers in the very early embryo, and then differentiate into two distinct mature liver cell types - the hepatocytes and cholangiocytes. During liver organogenesis hepatoblasts proliferate and migrate into the septum transversum to form the liver bud. Proliferation and differentiation of these cells are regulated by several soluble factors, such as hepatocyte growth factor, which is a mitogen of both hepatoblasts and mature hepatocytes. As they start to differentiate into hepatocytes and cholangiocytes, the cells begin to express hepatic markers like albumin and alpha-fetoprotein. Although hepatoblasts are specified embryonic liver cells that are bipotential for hepatocytes and cholangiocytes, a subset of liver cells (called oval cells) has been identified in adults that express stem cell markers, such as CD133 and cKIT, and has been suggested to have the same potential as hepatoblasts to differentiate into hepatocytes and cholangiocytes. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "hepatoblast"@en ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005026", "https://github.com/obophenotype/cell-ontology/issues/800" ; rdfs:subClassOf obo:CL_0000048 . obo:CL_0007000 obo:IAO_0000115 "Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins." ; terms:contributor ; oboInOwl:creation_date "2012-06-15T01:27:01Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "unsure of neural crest contribution. In VSAO we have develops_from CL:0000008" ; rdfs:label "preameloblast" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005176 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002077 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001763 ] . obo:CL_0007001 obo:IAO_0000115 "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." ; terms:contributor ; oboInOwl:creation_date "2012-06-15T02:51:27Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "scleroblast" ; a owl:Class ; rdfs:comment "Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts)" ; rdfs:label "skeletogenic cell" ; rdfs:subClassOf obo:CL_0000000 ; skos:prefLabel "skeletogenic cell" . obo:CL_0007002 obo:IAO_0000115 "Skeletogenic cell that has the potential to develop into a cementoblast." ; terms:contributor ; oboInOwl:creation_date "2012-06-15T04:37:13Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "precementoblast" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005176 ] . obo:CL_0007003 obo:IAO_0000115 "Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell." ; terms:contributor ; oboInOwl:creation_date "2012-06-15T05:15:11Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "preodontoblast" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005176 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000008 ] . obo:CL_0007004 obo:IAO_0000115 "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." ; terms:contributor ; oboInOwl:creation_date "2012-06-27T08:27:35Z"^^xsd:dateTime ; oboInOwl:hasDbXref "ZFA:0007084" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "premigratory neural crest cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0011012, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002342 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000133 ] ; skos:prefLabel "premigratory neural crest cell" . obo:CL_0007005 obo:IAO_0000115 "Cell that is part of the notochord." ; terms:contributor ; oboInOwl:creation_date "2012-06-27T08:47:31Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "NOTE: TO DO, notochord development still needs work." ; rdfs:label "notochordal cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002328 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0007006 ] . obo:CL_0007006 obo:IAO_0000115 "Mesodermal cell that is axially located and gives rise to the cells of the notochord." ; terms:contributor ; oboInOwl:creation_date "2012-06-27T08:52:41Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "axial mesodermal cell" ; a owl:Class ; rdfs:label "chordamesodermal cell" ; rdfs:subClassOf obo:CL_0000222, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004880 ] . obo:CL_0007007 obo:IAO_0000115 "Notochordal cell that is part of the outer epithelium of the notochord and surrounds the vacuolated notochord cells." ; terms:contributor ; oboInOwl:creation_date "2012-06-27T09:26:37Z"^^xsd:dateTime ; oboInOwl:hasDbXref "ZFA:0005744" ; a owl:Class ; rdfs:label "notochordal sheath cell" ; rdfs:subClassOf obo:CL_0007005 . obo:CL_0007008 obo:IAO_0000115 "Notochordal cell that is inner portion of the notochord and becomes vacuolated as development proceeds." ; terms:contributor ; oboInOwl:creation_date "2012-06-27T09:29:30Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "chordablast", "chordoblast" ; a owl:Class ; rdfs:label "notochordal vacuole cell" ; rdfs:subClassOf obo:CL_0007005 . obo:CL_0007009 obo:IAO_0000115 "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." ; terms:contributor ; oboInOwl:creation_date "2012-06-27T10:44:01Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "prechondroblast" ; rdfs:subClassOf obo:CL_0011026 ; skos:prefLabel "prechondroblast" . obo:CL_0007010 obo:IAO_0000115 "Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells." ; terms:contributor ; terms:description """Preosteoblast is a critical cell type involved in bone formation, crucial in a process known as ossification or osteogenesis. They are derived from mesenchymal stem cells and are an intermediate stage marking the transition from an osteoprogenitor cell to a fully differentiated osteoblast. The presence of preosteoblasts signifies the site of new bone deposition, highlighting their crucial role in skeletal development and in response to bone injury repairs. The primary function of preosteoblasts is to differentiate into osteoblasts, which are responsible for secreting osteoid (the unmineralized portion of bone matrix) and regulating the process of bone mineralization. Preosteoblasts are regulated by various growth factors and hormones, including bone morphogenic proteins (BMPs), fibroblast growth factors (FGFs), parathyroid hormone (PTH) and Vitamin D. However, the function of preosteoblasts is not limited to bone formation alone. In addition to osteogenesis, preosteoblasts significantly contribute to the maintenance of bone homeostasis through regulating the activity of osteoclasts - the cells responsible for bone resorption. This regulation is mediated through RANK/RANKL/OPG pathway signaling. Osteoprotegerin (OPG) released from the preosteoblasts acts as a decoy receptor for RANKL impairing osteoclast formation, hence preventing excessive bone resorption. This regulatory role indicates the dual functionality of preosteoblasts, which are indispensable for both the formation of new bone and the maintenance of existing bone tissue. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2012-06-27T10:57:21Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "osteoprogenitor cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "preosteoblast" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0007010" ; rdfs:subClassOf obo:CL_0001035, obo:CL_0002320, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008883 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000222 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] . obo:CL_0007011 obo:IAO_0000115 "Neuron that is part of the enteric nervous system." ; terms:contributor ; oboInOwl:creation_date "2012-06-28T08:20:31Z"^^xsd:dateTime ; oboInOwl:hasDbXref "ZFA:0005775" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "enteric neuron" ; rdfs:subClassOf obo:CL_0000029, obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002005 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002005 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002607 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002005 ] ) ] . obo:CL_0007012 obo:IAO_0000115 "Odontoblast that non-terminally differentiated, located in the odontogenic papilla and dentine tissue, and transforms from a odontoblast cell." ; a owl:Class ; rdfs:label "non-terminally differentiated odontoblast" ; rdfs:subClassOf obo:CL_0000060, obo:CL_0011026 . obo:CL_0007013 obo:IAO_0000115 "Odontoblast that is terminally differentiated and derived from an odontogenic papilla and associated with dentine." ; a owl:Class ; rdfs:label "terminally differentiated odontoblast" ; rdfs:subClassOf obo:CL_0000060 . obo:CL_0007014 obo:IAO_0000115 "OBSOLETE: A cultured cell that has been passaged at least one time in culture." ; obo:IAO_0100001 obo:CLO_0000001 ; terms:contributor ; oboInOwl:creation_date "2012-11-28T11:54:59Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "passaged cultured cell" ; a owl:Class ; rdfs:comment """Obsoleted in July 2013 and replaced by the CLO 'cell line cell' class, as a result of CLO-OBI-CL alignment efforts. Covers cells actively being cultured or stored in a quiescent state for future use.""" ; rdfs:label "obsolete cell line cell" ; owl:deprecated true . obo:CL_0007015 obo:IAO_0000115 "OBSOLETE: A cell line cell that is expected to be capable of replicating a limited number of times in culture before undergoing senescence. Mortal cell line cells cannot be propagated indefinitely (as immortal cell line cells can)." ; obo:IAO_0100001 obo:CLO_0000018 ; terms:contributor ; oboInOwl:creation_date "2012-11-28T11:56:20Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "finite cell line cell" ; oboInOwl:hasRelatedSynonym "primary cell line cell" ; a owl:Class ; rdfs:comment """Obsoleted in July 2013 and replaced by the CLO 'mortal cell line cell' class, as a result of CLO-OBI-CL alignment efforts. Covers cells actively being cultured or stored in a quiescent state for future use.""" ; rdfs:label "obsolete mortal cell line cell" ; owl:deprecated true . obo:CL_0007016 obo:IAO_0000115 "Muscle precursor cell that is adjacent to the notochord and part of the presomitic mesoderm." ; terms:contributor ; oboInOwl:creation_date "2012-12-30T12:43:15Z"^^xsd:dateTime ; oboInOwl:hasDbXref "ZFA:0000003" ; a owl:Class ; rdfs:comment "In teleosts, adaxial cells give rise to slow muscle myoblasts." ; rdfs:label "adaxial cell" ; rdfs:subClassOf obo:CL_0000680, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003059 ] . obo:CL_0007017 obo:IAO_0000115 "An epidermal cell with apical microvilli or a single apical projection have synaptic associations with nerve fibres in the epidermis." ; terms:contributor ; a owl:Class ; rdfs:comment "Taxon specificity not yet fully known, but are known in anuran larvae but not in adults." ; rdfs:label "Stiftchenzellen" ; rdfs:subClassOf obo:CL_0000206, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005902 ] . obo:CL_0007018 obo:IAO_0000115 "Ciliated cell of the embryonic epidermis and functions in embryonic movements." ; terms:contributor ; a owl:Class ; rdfs:comment "Taxon specificity not clear -present in embryonic anurans." ; rdfs:label "epidermal ciliary cell"@en ; rdfs:subClassOf obo:CL_0000064, obo:CL_0002321, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] . obo:CL_0007019 terms:contributor ; a owl:Class ; rdfs:comment "taxon specificity not clear. Appears in early larval stages of anurans and persists after metamorphosis." ; rdfs:label "epidermal mucus secreting cell"@en ; rdfs:subClassOf obo:CL_0000319 . obo:CL_0007020 obo:IAO_0000115 "Characteristic early embryonic cell with a bottle or flask shape that is first to migrate inwards at the blastopore during gastrulation in amphibians." ; terms:contributor ; a owl:Class ; rdfs:label "bottle cell"@en ; rdfs:subClassOf obo:CL_0000007 . obo:CL_0007021 obo:IAO_0000115 "Secretory cell that produces a chemical mixture that triggers antipredator behavior. The substance is released only upon disruption of the epidermis. [Behavior of teleost fishes, second edition, edited by Pitcher, 1992]" ; terms:contributor ; oboInOwl:hasExactSynonym "alarm substance secreting cell", "club cell (zebrafish)" ; oboInOwl:hasRelatedSynonym "club cell" ; a owl:Class ; rdfs:label "alarm substance cell"@en ; rdfs:subClassOf obo:CL_0000151, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] . obo:CL_0007022 obo:IAO_0000115 "A specialized pore forming cell of the follicle, located adjacent to the animal pole of the oocyte. The micropylar cell makes the single micropyle (pore) through the chorion through which the sperm fertilizes the egg." ; terms:contributor ; oboInOwl:hasDbXref "ZFA:0005239" ; oboInOwl:hasExactSynonym "plug cell" ; a owl:Class ; rdfs:label "micropylar cell"@en ; rdfs:subClassOf obo:CL_0002174 . obo:CL_0007023 obo:IAO_0000115 "Epidermal cell rich in mitochondria. In amphibians, appears during metamorphosis." ; terms:contributor ; a owl:Class ; rdfs:label "flask cell"@en ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] . obo:CL_0008000 obo:IAO_0000115 "Any muscle cell in which the fibers are not organised into sarcomeres." ; a owl:Class ; rdfs:label "non-striated muscle cell" ; rdfs:subClassOf obo:CL_0000187 ; skos:prefLabel "non-striated muscle cell" . obo:CL_0008001 obo:IAO_0000115 "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "hematopoietic precursor cell" ; rdfs:subClassOf obo:CL_0000988 ; skos:prefLabel "hematopoietic precursor cell" . obo:CL_0008002 obo:IAO_0000115 "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." ; oboInOwl:hasDbXref "MESH:D018485" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "skeletal muscle fiber"@en ; rdfs:subClassOf obo:CL_0000188, obo:CL_0002372, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000515 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001134 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002478 ] ) ] ; skos:prefLabel "skeletal muscle fiber" . obo:CL_0008003 obo:IAO_0000115 "A myotube that is part of some somatic muscle. Examples include arthropod somatic muscle cells." ; a owl:Class ; rdfs:label "somatic muscle myotube" ; rdfs:subClassOf obo:CL_0002372, obo:CL_0008004 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0008004 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002478 ] ) ] . obo:CL_0008004 obo:IAO_0000115 "A muscle cell that is part of some somatic muscle." ; oboInOwl:hasDbXref "FBbt:00005073" ; a owl:Class ; rdfs:label "somatic muscle cell"@en ; rdfs:subClassOf obo:CL_0000187 . obo:CL_0008005 obo:IAO_0000115 "A somatic muscle cell that is obliquely striated and mononucleated. Examples include the somatic muscles of nematodes." ; a owl:Class ; rdfs:label "obliquely striated somatic muscle cell" ; rdfs:subClassOf obo:CL_0000226, obo:CL_0000444, obo:CL_0008004 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0008004 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002479 ] ) ] . obo:CL_0008006 obo:IAO_0000115 "A myoblast that detemines the properties (size, shape and attachment to the epidermis) of a `somatic muscle myotube` (CL:0008003) . It develops into a somatic muscle myotube via fusion with `fusion component myoblasts` (CL:0000621)." ; a owl:Class ; rdfs:label "muscle founder cell"@en ; rdfs:subClassOf obo:CL_0008018 . obo:CL_0008007 obo:IAO_0000115 "A muscle cell that is part of some visceral muscle." ; oboInOwl:hasDbXref "FBbt:00005070" ; a owl:Class ; rdfs:label "visceral muscle cell"@en ; rdfs:subClassOf obo:CL_0000187, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8600004 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8600004 ] ) ] ; skos:prefLabel "visceral muscle cell" . obo:CL_0008008 obo:IAO_0000115 "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods." ; a owl:Class ; rdfs:label "striated visceral muscle cell"@en ; rdfs:subClassOf obo:CL_0000737, obo:CL_0008007 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0008007 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001410 ] ) ] ) ] . obo:CL_0008009 obo:IAO_0000115 "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods." ; a owl:Class ; rdfs:label "transversely striated visceral muscle cell"@en ; rdfs:subClassOf obo:CL_0008008, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002478 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0008007 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002478 ] ) ] ) ] . obo:CL_0008010 obo:IAO_0000115 "A cranial motor neuron whose soma is located in the midbrain andor hindbrain and which innervates the skeletal muscles of the eye or tongue." ; a owl:Class ; rdfs:label "cranial somatomotor neuron" ; rdfs:subClassOf obo:CL_0005024, obo:CL_0015000 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0015000 [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_0008002 ] ) ] . obo:CL_0008011 obo:IAO_0000115 "A skeletal muscle satellite cell that divides by stem cell division. A proportion of this population undergoes symmetric stem cell division, producing two skeletal muscle satellite stem cells. The rest undergo asymmetric stem cell division - retaining their identity while budding off a daughter cell that differentiates into an adult skeletal muscle myoblast." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "skeletal muscle satellite stem cell" ; rdfs:subClassOf obo:CL_0000035, obo:CL_0000594 ; owl:disjointWith obo:CL_0008020 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000594 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001400 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0017145 ] ) ] . obo:CL_0008012 obo:IAO_0000115 "A skeletal muscle satellite cell that is mitotically quiescent. These cells are wedge shaped and have a large nuclear to cytoplasmic ratio with few organelles, a small nucleus and condensed interphase chromatin. Satellite cells typically remain in this state until activated following muscle damage." ; a owl:Class ; rdfs:label "quiescent skeletal muscle satellite cell" ; rdfs:subClassOf obo:CL_0000594 . obo:CL_0008013 obo:IAO_0000115 "A visceromotor motor neuron whose soma is located in the hindbrain, and which synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles of the head." ; a owl:Class ; rdfs:label "cranial visceromotor neuron"@en ; rdfs:subClassOf obo:CL_0005025, obo:CL_0015000, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002028 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005025 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002028 ] ) ] . obo:CL_0008014 obo:IAO_0000115 "A motor neuron that is capable of directly inducing muscle contraction." ; a owl:Class ; rdfs:comment "In vertebrates, all motor neurons are excitatory, but various types of inhibitory motor neurons exist in invertebrates." ; rdfs:label "obsolete excitatory motor neuron"@en ; owl:deprecated true . obo:CL_0008015 obo:IAO_0000115 "A motor neuron that is capable of directly inhibiting muscle contraction." ; obo:RO_0002161 obo:NCBITaxon_7742 ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "In vertebrates, all motor neurons are excitatory, but various types of inhibitory motor neurons exist in invertebrates." ; rdfs:label "inhibitory motor neuron"@en ; rdfs:subClassOf obo:CL_0000100 . obo:CL_0008016 obo:IAO_0000115 "A skeletal muscle satellite cell that has become mitotically active - typically following muscle damage." ; a owl:Class ; rdfs:label "activated skeletal muscle satellite cell" ; rdfs:subClassOf obo:CL_0000594, _:genid11008 . obo:CL_0008017 obo:IAO_0000115 "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers." ; oboInOwl:hasBroadSynonym "myogenic precursor cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins." ; rdfs:label "adult skeletal muscle myoblast" ; rdfs:subClassOf obo:CL_0000188, obo:CL_0000515 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000056 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001134 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0008002 ] ) ] . obo:CL_0008018 obo:IAO_0000115 "A myoblast that is commited to developing into a somatic muscle." ; a owl:Class ; rdfs:label "somatic muscle myoblast" ; rdfs:subClassOf obo:CL_0000056, [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0008003 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000056 [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0008003 ] ) ] . obo:CL_0008019 obo:IAO_0000115 "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "mesenchyme cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "mesenchymal cell" ; rdfs:subClassOf obo:CL_0000219, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003104 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0016477 ] ; skos:prefLabel "mesenchymal cell" . obo:CL_0008020 obo:IAO_0000115 "A skeletal muscle satellite cell that undergoes symmetric division to produce two adult skeleltal muscle myoblasts." ; a owl:Class ; rdfs:label "skeletal muscle satellite myogenic cell" ; rdfs:subClassOf obo:CL_0000594, [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0008017 ] . obo:CL_0008021 obo:IAO_0000115 "Any peripheral nervous system neuron that has its soma located in some anterior lateral line ganglion." ; a owl:Class ; rdfs:label "anterior lateral line ganglion neuron" ; rdfs:subClassOf obo:CL_2000031, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_2001391 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000032 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_2001391 ] ) ] . obo:CL_0008022 obo:IAO_0000115 "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves." ; a owl:Class ; rdfs:label "endocardial cushion cell" ; rdfs:subClassOf obo:CL_0000569, obo:CL_0002494, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002062 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000569 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002062 ] ) ] . obo:CL_0008023 obo:IAO_0100001 obo:CL_0002548 ; a owl:Class ; rdfs:comment "Duplicate term." ; rdfs:label "obsolete cardiac fibroblast" ; owl:deprecated true . obo:CL_0008024 obo:IAO_0000115 "An endocrine cell that is part of the pancreas." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreatic endocrine cell" ; rdfs:subClassOf obo:CL_0000083, obo:CL_0000164 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000163 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:CL_0008025 obo:IAO_0000115 "A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter." ; oboInOwl:hasDbXref "ZFA:0005873" ; a owl:Class ; rdfs:label "noradrenergic neuron" ; rdfs:subClassOf obo:CL_0000459, obo:CL_4033050, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061533 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061533 ] ) ] . obo:CL_0008026 obo:IAO_0000115 "An epithelial cell that is part of the epithelium of a tracheal tube in an open tracheal system, such as that found in insects." ; oboInOwl:hasDbXref "FBbt:00005038" ; a owl:Class ; rdfs:label "open tracheal system tracheocyte" ; rdfs:subClassOf obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003127 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003127 ] ) ] . obo:CL_0008027 obo:IAO_0000115 "A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells. These neurons have axons that arborize and synapse to targets in inner plexiform layers 4 and 5 and depolarize in response to light." ; terms:contributor ; oboInOwl:creation_date "2017-06-29T11:05:22Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "rod bipolar cell (sensu Mus)" ; rdfs:subClassOf obo:CL_0000751 . obo:CL_0008028 obo:IAO_0000115 "Any neuron that is capable of part of some visual perception." ; terms:contributor ; oboInOwl:creation_date "2017-07-09T19:12:36Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "visual system neuron" ; rdfs:subClassOf obo:CL_0000540, [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007601 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007601 ] ) ] ; skos:prefLabel "visual system neuron" . obo:CL_0008029 obo:IAO_0000233 ; terms:contributor ; oboInOwl:creation_date "2017-07-12T11:10:52Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Consider GABAergic neuron or inhibitory interneuron instead. Do note that not all GABAergic neurons are inhibitory (see PMID:12209121) and replacing inhibitory neuron with GABAergic neuron should be done with caution." ; rdfs:label "obsolete inhibitory neuron" ; owl:deprecated true . obo:CL_0008030 obo:IAO_0000233 ; terms:contributor ; oboInOwl:creation_date "2017-07-12T11:11:06Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Consider using glutamatergic neuron instead. Do note that not all glutamatergic neurons are excitatory and replacing excitatory neuron with glutamatergic neuron should be done with caution." ; rdfs:label "obsolete excitatory neuron" ; owl:deprecated true . obo:CL_0008031 obo:IAO_0000115 "An interneuron that has its soma located in the cerebral cortex." ; oboInOwl:hasExactSynonym "cerebral cortex interneuron" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cortical interneuron"@en ; rdfs:subClassOf obo:CL_0000099, obo:CL_0010012 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] . obo:CL_0008032 obo:IAO_0000115 "A GABAergic interneuron in human cortical layer 1 that has large rosehip-shaped axonal boutons and compact arborization." ; a owl:Class ; rdfs:comment "A rosehip cell has been shown to have an immunohistochemical profile GAD1+CCK+, CNR1–SST–CALB2–PVALB– that matches a single transcriptomically defined cell type whose specific molecular marker signature is not seen in mouse cortex." ; rdfs:label "rosehip neuron"@en ; rdfs:subClassOf obo:CL_0010011, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005390 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000005110 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000007785 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011467 ] . obo:CL_0008033 obo:IAO_0000115 "A pericyte of the decidual vasculature." ; terms:contributor ; oboInOwl:creation_date "2020-02-29T11:45:57Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "decidual perivascular cell" ; oboInOwl:inSubset cl:added_for_HCA ; a owl:Class ; rdfs:label "decidual pericyte"@en ; rdfs:subClassOf obo:CL_0000349, obo:CL_2000078, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002450 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000669 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002450 ] ) ] . obo:CL_0008034 obo:IAO_0000115 "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2020-02-29T17:33:55Z"^^xsd:dateTime ; oboInOwl:hasDbXref "ZFA:0005944" ; oboInOwl:inSubset cl:added_for_HCA, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "mural cell"@en ; rdfs:subClassOf obo:CL_4033054 . obo:CL_0008035 obo:IAO_0000115 "Any vascular associated smooth muscle cell that is part of some microcirculatory vessel." ; terms:contributor ; oboInOwl:creation_date "2020-02-29T17:37:00Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "microcirculation associated smooth muscle cell"@en ; rdfs:subClassOf obo:CL_0000359, obo:CL_0008034, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010523 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010523 ] ) ] . obo:CL_0008036 obo:IAO_0000115 "A trophoblast cell that is not part of a placental villous." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Extravillous trophoblasts (EVTs), a specialized subset of trophoblast cells, play crucial roles in establishing and sustaining pregnancy. Firstly, they anchor the fetus to the maternal tissue, providing structural stability. Secondly, they are instrumental in modifying the maternal spiral arteries to ensure an adequate supply of maternal blood to the placenta and the developing fetus. EVTs invade maternal decidua and myometrium and replace the endothelial lining of the spiral arteries, transforming these high-resistance, narrow vessels into low-resistance, wide vessels, favouring higher blood flow. Thirdly, these cells also play an immunological role, creating an environment conducive to the acceptance of the semi-allogeneic fetus, by expressing non-classical MHC molecules, thereby averting any potential maternal immune response towards fetal tissues. While EVTs are commonly associated with healthy pregnancies, abnormalities in their function or development have been connected to problematic pregnancies. Conditions like pre-eclampsia and fetal growth restriction (FGR) may arise if EVT cells do not effectively invade the maternal decidua or adequately remodel. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2020-03-02T08:45:06Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "EVT", "extravillous cytotrophloblast" ; oboInOwl:inSubset cl:added_for_HCA, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "extravillous trophoblast"@en ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0008036" ; rdfs:subClassOf obo:CL_0000351 . obo:CL_0008037 obo:IAO_0000115 "A lower motor neuron that innervates only intrafusal muscle fibers. Unlike the alpha motor neurons, gamma motor neurons do not directly adjust the lengthening or shortening of muscles but function in adjusting the sensitivity of muscle spindles and in keeping muscle spindles taut, thereby allowing the continued firing of alpha neurons." ; oboInOwl:hasDbXref "FMA:83660", "MESH:D009047", "SAO:143800623" ; oboInOwl:hasExactSynonym "fusimotor neuron" ; a owl:Class ; rdfs:label "gamma motor neuron"@en ; rdfs:subClassOf obo:CL_0008039, [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_0008047 ] . obo:CL_0008038 obo:IAO_0000115 "A large, multipolar lower motor neuron of the brainstem and spinal cord that innervates the extrafusal muscle fibers of skeletal muscle and are directly responsible for initiating their contraction. While their cell bodies are in the CNS (in the anterior gray horn of the spinal cord), they are part of the somatic nervous system - a branch of the PNS." ; terms:contributor ; oboInOwl:creation_date "2020-09-23T20:16:26Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "alpha motoneuron" ; a owl:Class ; rdfs:label "alpha motor neuron"@en ; rdfs:subClassOf obo:CL_0008039, [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_0008046 ] . obo:CL_0008039 obo:IAO_0000115 "The motor neurons of vertebrates that directly innervate skeletal muscles. They receive input from upper motor neurons." ; terms:contributor ; oboInOwl:creation_date "2020-09-23T20:22:07Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:84632" ; a owl:Class ; rdfs:label "lower motor neuron"@en ; rdfs:subClassOf obo:CL_0005024 . obo:CL_0008040 obo:IAO_0000115 "An endothelial cell of the venule that is squamous shaped. This is in contrast to the cubodial shape of high endothelial venule cells." ; terms:contributor ; terms:date "2024-07-03T19:52:47Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "squamous endothelial cell of venule"@en ; rdfs:subClassOf obo:CL_0002653, obo:CL_1000414 . obo:CL_0008041 obo:IAO_0000115 "A mesothelial cell that is part of the intestinal serosa." ; terms:contributor ; terms:date "2025-02-04T18:42:26Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "mesothelial cell of intestine" ; rdfs:subClassOf obo:CL_0000077, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001243 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001243 ] ) ] . obo:CL_0008042 obo:IAO_0000115 "A tanycyte of the subfornical organ (SFO). These cells extend long and slender fibers extending from their cell bodies in the ependyma toward fenestrated capillaries associated with the SFO, where they form a dense network surrounding these capillaries." ; terms:contributor ; terms:date "2025-03-11T11:43:39Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "tanycyte-like cell of subfornical organ" ; a owl:Class ; rdfs:label "tanycyte of subfornical organ" ; rdfs:subClassOf obo:CL_0002085, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002219 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002085 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002219 ] ) ] . obo:CL_0008044 obo:IAO_0000115 "A tanycyte of the area postrema (AP). These cells extend long and slender fibers extending from their cell bodies in the ependyma toward fenestrated capillaries associated with the AP, where they form a dense network surrounding these capillaries." ; terms:contributor ; terms:date "2025-03-11T12:09:13Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "tanycyte-like cell of area postrema" ; a owl:Class ; rdfs:label "tanycyte of area postrema" ; rdfs:subClassOf obo:CL_0002085, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002162 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002085 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002162 ] ) ] . obo:CL_0008045 obo:IAO_0000115 "A tanycyte of the subcommisural organ (SCO). These cells extend long and slender fibers extending from their cell bodies in the ependyma toward fenestrated capillaries associated with the SCO, where they form a dense network surrounding these capillaries." ; terms:contributor ; terms:date "2025-03-11T12:09:34Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "tanycyte-like cell of subcommissural organ" ; a owl:Class ; rdfs:label "tanycyte of subcommissural organ" ; rdfs:subClassOf obo:CL_0002085, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002139 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002085 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002139 ] ) ] . obo:CL_0008046 obo:IAO_0000115 "A skeletal muscle fiber that is innervated by alpha motor neuron and generates tension by contracting, thereby allowing for skeletal movement. These fibers make up the large mass of skeletal muscle tissue and are attached to bones by tendons." ; terms:contributor ; oboInOwl:creation_date "2020-09-26T21:06:15Z"^^xsd:dateTime ; oboInOwl:hasDbXref "TH:H3.03.00.0.00007" ; oboInOwl:hasExactSynonym "myofibra extrafusalis" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "extrafusal muscle fiber"@en ; rdfs:subClassOf obo:CL_0008002, [ a owl:Restriction ; owl:onProperty obo:RO_0002103 ; owl:someValuesFrom obo:CL_0008038 ] ; owl:disjointWith obo:CL_0008047 . obo:CL_0008047 obo:IAO_0000115 "A skeletal muscle fiber that is part of a muscle spindle. These are specialized muscle fibers that serve as proprioceptors, detecting the amount and rate of change in length of a muscle. They are innervated by both sensory neurons and motor neurons (gamma and beta motorneurons, collectively referred to as fusimotor neurons)." ; terms:contributor ; oboInOwl:creation_date "2020-09-26T21:07:01Z"^^xsd:dateTime ; oboInOwl:hasDbXref "TH:H3.03.00.0.00012" ; oboInOwl:hasExactSynonym "myofibra intrafusalis" ; a owl:Class ; rdfs:label "intrafusal muscle fiber"@en ; rdfs:subClassOf obo:CL_0002319, obo:CL_0008002, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003718 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0008002 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003718 ] ) ] . obo:CL_0008048 obo:IAO_0000115 "A glutamatergic motor neuron with a soma in the brainstem or cerebral cortex. They do not synapse directly to muscles but rather to lower motor neurons, which do. They are the main controllers of voluntary movement." ; terms:contributor ; oboInOwl:creation_date "2020-09-28T09:41:48Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "upper motor neuron"@en ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000100, obo:CL_0000679, [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_0008039 ] . obo:CL_0008049 obo:IAO_0000115 "A giant pyramidal neuron with a soma in layer Vb of the primary motor cortex that sends its axons down the spinal cord via the corticospinal tract, either synapsing directly with alpha motor neurons, or targeting interneurons in the spinal cord. In humans, Betz cells are the largest known in the central nervous system." ; obo:RO_0002175 obo:NCBITaxon_9443 ; terms:contributor ; oboInOwl:creation_date "2020-09-28T09:52:58Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "pyramidal cell of Betz" ; a owl:Class ; rdfs:label "Betz cell"@en ; rdfs:subClassOf obo:CL_2000049, obo:CL_4023041, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0022315 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002101 ; owl:someValuesFrom obo:UBERON_0002707 ] ; foaf:depiction "https://en.wikipedia.org/w/index.php?title=Betz_cell&oldid=977472330#/media/File:GolgiStainedPyramidalCell.jpg" . obo:CL_0008053 obo:IAO_0000115 "A capillary endothelial cell that is part of the circumventricular organs (CVOs), characterized by fenestrations that facilitate selective permeability to molecules, distinguishing it from the non-fenestrated endothelial cells of the blood-brain barrier. This cell is integral to the unique vascular structure of CVOs, which lack a traditional blood-brain barrier. It enables bidirectional exchange of polar molecules between blood and neural tissue, supporting neuroendocrine signaling, fluid balance, and immune responses. It is marked by the expression of PLVAP, a component of the fenestral diaphragm, in both rodents and humans." ; terms:contributor ; terms:date "2025-03-14T12:44:38Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "circumventricular organ capillary endothelial cell" ; rdfs:subClassOf obo:CL_0000666, obo:CL_0002144, obo:CL_2000044, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005408 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002144 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005408 ] ) ] . obo:CL_0008055 obo:IAO_0000115 "A secretory epithelial cell of the respiratory tract epithelium. These cells have an endodermal origin." ; terms:contributor "https://orcid.org/0000-0002-7073-9172" ; terms:date "2025-02-19T16:01:02Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "respiratory tract secretory epithelial cell" ; rdfs:subClassOf obo:CL_0002368, obo:CL_1100001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1100001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004802 ] ) ] . obo:CL_0008059 obo:IAO_0000115 "A neuron that releases both gamma-aminobutyric acid and glycine as vesicular neurotransmitters. Examples include types of amacrine cell and types of cerebellar inhibitory neurons." ; terms:contributor ; terms:date "2025-06-19T09:57:55Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "GABA-Gly neuron" ; rdfs:subClassOf obo:CL_0000617, obo:CL_1001509 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061537 ] ) ] . obo:CL_0008060 obo:IAO_0000115 "A neuron that releases both gamma-aminobutyric acid and glutamate as vesicular neurotransmitters." ; terms:contributor ; terms:date "2025-06-19T10:06:06Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "GABA-Glut neuron" ; rdfs:subClassOf obo:CL_0000617, obo:CL_0000679 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061535 ] ) ] . obo:CL_0008061 obo:IAO_0000115 "A neuron that releases both gamma-aminobutyric acid and acetylcholine as vesicular neurotransmitters. Examples include some types of striatal interneuron." ; terms:contributor ; terms:date "2025-06-19T10:13:06Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "GABA-Chol neuron" ; rdfs:subClassOf obo:CL_0000108, obo:CL_0000617 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0014055 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ) ] . obo:CL_0009000 obo:IAO_0000115 "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." ; oboInOwl:hasExactSynonym "spinal sensory neuron" ; a owl:Class ; rdfs:label "sensory neuron of spinal nerve" ; rdfs:subClassOf obo:CL_3000004, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001780 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000101 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001780 ] ) ] . obo:CL_0009001 obo:IAO_0000115 "Any cell in the compound eye, a light sensing organ composed of ommatidia." ; oboInOwl:hasDbXref "GOC:pr", "PMID:12021768" ; a owl:Class ; rdfs:label "compound eye retinal cell" ; rdfs:subClassOf obo:CL_0009004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005388 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000018 ] ) ] ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005388 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000018 ] ) ] ] ) ] . obo:CL_0009002 obo:IAO_0000115 "Any cell participating in the inflammatory response to a foreign substance, e.g. neutrophil, macrophage." ; oboInOwl:hasDbXref "GOC:pr", "http://en.wikipedia.org/wiki/Inflammatory_response" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "inflammatory cell" ; rdfs:subClassOf obo:CL_0000000, [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0006954 ] . obo:CL_0009003 obo:IAO_0000115 "Any cell in the midgut (middle subdivision of a digestive tract) of an insect larva." ; oboInOwl:hasDbXref "GOC:pr", "http://en.wikipedia.org/wiki/Insect#Midgut" ; a owl:Class ; rdfs:label "larval midgut cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/710" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002548 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_50557 ] . obo:CL_0009004 obo:IAO_0000115 "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." ; oboInOwl:hasDbXref "PMID:10702418" ; a owl:Class ; rdfs:label "retinal cell" ; rdfs:subClassOf obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005388 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002319 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005388 ] ) ] ; skos:prefLabel "retinal cell" . obo:CL_0009005 obo:IAO_0000115 "Any cell in a salivary gland." ; oboInOwl:hasDbXref "GOC:pr", "http://en.wikipedia.org/wiki/Salivary_gland" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "salivary gland cell" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001044 ] . obo:CL_0009006 obo:IAO_0000115 "An enteroendocrine cell that is located in the small intestine." ; terms:contributor ; terms:description """The enteroendocrine cell of the small intestine is a specialized type of cell that forms part of the lining of the intestinal wall. These cells are interspersed among absorptive cells, mucus-secreting goblet cells, and other gut cell types, forming the crypt-villus axis, which is the functional unit of the small intestinal epithelium. Functionally, enteroendocrine cells play a pivotal role in the gut-endocrine system, which is responsible for the digestive process. These cells translate the luminal nutrient status into hormonal signals thereby acting as chemosensors. They contain secretory granules at their base which release hormones into the bloodstream following chemo-sensation. The hormones they secrete perform diverse functions including regulating gastric secretion, gut motility, insulin release, appetite control and other local and systemic effects. In addition to their endocrine functions, enteroendocrine cells also play a part in the modulation of the immune response in the gut. They can secrete cytokines and chemokines that have a role in directing the immune response to invading pathogens. Moreover, emerging research suggests that these cells play a role in maintaining the balance between gut resident bacteria, known as the gut microbiota, and the host. As such, a comprehensive understanding of the enteroendocrine cells of the small intestine underpins knowledge in nutrition, endocrinology, and various gastroenterological conditions. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasExactSynonym "small intestine enteroendocrine cell" ; oboInOwl:inSubset cl:cellxgene_subset, pato:location_grouping ; a owl:Class ; rdfs:label "enteroendocrine cell of small intestine" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009006" ; rdfs:subClassOf obo:CL_1001516, obo:CL_1001598 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000164 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] ; foaf:depiction . obo:CL_0009007 obo:IAO_0000115 "A macrophage which is resident in the lamina propria of the small intestine." ; terms:contributor ; oboInOwl:hasBroadSynonym "macrophage of small intestine" ; oboInOwl:hasExactSynonym "small intestine lamina propria resident macrophage" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "gastrointestinal tract (lamina propria) macrophage of small intestine" ; rdfs:subClassOf obo:CL_0000865, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001238 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000885 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001238 ] ) ] . obo:CL_0009008 obo:IAO_0000115 "A macrophage which is resident in the lamina propria of the large intestine." ; terms:contributor ; oboInOwl:hasBroadSynonym "macrophage of large intestine" ; oboInOwl:hasExactSynonym "large intestine lamina propria resident macrophage" ; oboInOwl:inSubset cl:cellxgene_subset, pato:location_grouping ; a owl:Class ; rdfs:label "gastrointestinal tract (lamina propria) macrophage of large intestine" ; rdfs:subClassOf obo:CL_0000865, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011189 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000885 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011189 ] ) ] . obo:CL_0009009 obo:IAO_0000115 "A paneth cell that is located in the epithelium of the colon." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Paneth cells of the colon are specialized secretory epithelial cells that can be found in the large intestine, albeit in small numbers compared with the small intestine where Paneth cells are more abundant. Under disease conditions such as inflammatory bowel disease, Paneth cells increase in numbers in the colon. They reside in the crypts of Lieberkühn, which are glandular structures embedded within the mucosal layer of the small and large intestine. Paneth cells play a crucial role in maintaining intestinal homeostasis and acting as a frontline of defense in our bodies against ingested microbes. They achieve this through the secretion of antimicrobial peptides and proteins such as lysozyme and defensins, which can directly kill or inhibit the growth of various bacteria, fungi, and viruses. They degranulate these substances into the intestinal lumen, especially under conditions of pathogenic invasion or damage to the epithelial lining. Moreover, Paneth cells are essential for the maintenance of intestinal stem cells, which continually replace the epithelium of the intestine. They create a niche for these stem cells at the base of the crypts, secreting various signaling molecules and factors that are essential for the growth and differentiation of intestinal stem cells. In essence, the existence and function of Paneth cells are fundamental to the overall gut health and immune defense system, by providing both antimicrobial functions and a conducive environment for the renewal of the intestinal lining. The role of Paneth cells specifically in the colon is of interest in the context of inflammatory bowel disease, such as ulcerative colitis and Crohn’s disease: Their presence in the colon is thought to represent Paneth cell metaplasia and indicates a chronic inflammatory state. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasBroadSynonym "paneth cell of epithelium of large intestine" ; oboInOwl:hasExactSynonym "paneth cell of epithelium of colon", "paneth-like cell" ; oboInOwl:inSubset cl:cellxgene_subset, pato:location_grouping, core:human_reference_atlas ; a owl:Class ; rdfs:label "paneth cell of colon" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009009" ; rdfs:subClassOf obo:CL_0000510, obo:CL_1001588 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000510 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000397 ] ) ] . obo:CL_0009010 obo:IAO_0000115 "Transit-amplifying cells (TACs) are an undifferentiated population in transition between stem cells and differentiated cells." ; terms:contributor ; oboInOwl:hasExactSynonym "transient amplifying cell", "transit amplifying progenitor cell", "transit-amplifying cell" ; oboInOwl:hasRelatedSynonym "TAC", "TACs" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "transit amplifying cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000034 ] . obo:CL_0009011 obo:IAO_0000115 "A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the colon. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """Transit amplifying cells (TACs) are an intermediate, undifferentiated population between stem cells and differentiated cells. They can be found in multiple regions such as the small intestine and the colon. TACs of the colon, are integral components of the colonic crypts and vital players in the maintenance of colonic tissue. These cells serve a critical function in the rapid and constant renewal of the epithelium lining the colon, with the whole epithelial surface renewed approximately every 5-7 days. They divide rapidly and progressively differentiate into mature columnar epithelium cells, including enterocytes, goblet cells, and enteroendocrine cells. The continued proliferation of transit amplifying cells is fundamental to maintain the balance in cell population while preventing tissue degeneration and maintaining a state of homeostasis. However, uncontrolled proliferation and compromised differentiation capacity can contribute to the development of colon cancers. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasBroadSynonym "transit amplifying cell of large intestine" ; oboInOwl:hasExactSynonym "colon transit amplifying cell", "transient amplifying cell of colon", "transient amplifying cell of crypt of Lieberkuhn of colon", "transit amplifying cell of crypt of Lieberkuhn of colon", "transit-amplifying cell of colon" ; oboInOwl:inSubset cl:cellxgene_subset, pato:location_grouping, core:human_reference_atlas ; a owl:Class ; rdfs:label "transit amplifying cell of colon" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009011" ; rdfs:subClassOf obo:CL_0002253, obo:CL_4047017, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4047017 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013485 ] ) ] . obo:CL_0009012 obo:IAO_0000115 "A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the small intestine. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells." ; terms:contributor ; terms:description """Transit amplifying cells (TACs) represent an intermediate population between stem cells and fully differentiated cells, and can be found in multiple regions such as the colon and the small intestine. The small intestine's efficiency in absorbing nutrients, its protective barrier function, and its innate cellular renewal every few days is largely dependent on the role played by these TACs. TACs of the small intestine are primarily present in the crypt-villus structure of the intestine, more specifically in the crypt region. They originate from Lgr5+ intestinal stem cells that reside at the base of the crypts. Following their derivation from stem cells, TACs undergo up to six rounds of rapid division over a 48-72 hour period, effectively amplifying the cell population, hence their name. During this process, they gradually migrate upward along the walls of the crypt from where they differentiate into diverse mature cell types such as enterocytes, goblet cells, and Paneth cells. TACs serve as an important element in the homeostasis and regeneration of the intestinal epithelium, amplifying the pool of cells available for differentiation. They also minimize genetic errors during DNA replication by serving as a 'buffer zone' between the long-lived stem cells and the terminal differentiated cells of the gut lining, thus reducing the potential for propagation of mutation-causing defects. Lastly, TACs play an essential part in gastrointestinal tissue repair following injury or inflammation. Their rapid proliferation and subsequent differentiation abilities often help expedite the wound healing process in the intestinal epithelium. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasExactSynonym "small intestine transit amplifying cell", "transient amplifying cell of crypt of Lieberkuhn of small intestine", "transient amplifying cell of small intestine", "transit amplifying cell of crypt of Lieberkuhn of small intestine", "transit-amplifying cell of small intestine" ; oboInOwl:inSubset cl:cellxgene_subset, pato:location_grouping ; a owl:Class ; rdfs:label "transit amplifying cell of small intestine" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009012" ; rdfs:subClassOf obo:CL_0002254, obo:CL_4047017, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001241 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4047017 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001241 ] ) ] ; foaf:depiction . obo:CL_0009013 obo:IAO_0000115 "A progenitor cell with hepatic and biliary lineage potential, identified in mouse and human, and anatomically restricted to the ductal plate of fetal liver." ; terms:contributor ; oboInOwl:hasExactSynonym "HHyP cell", "fetal hepatobiliary hybrid progenitor cell" ; oboInOwl:inSubset cl:added_for_HCA ; a owl:Class ; rdfs:label "fetal hepatobiliary progenitor cell" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_40674 ] . obo:CL_0009014 obo:IAO_0000115 "A lymphocyte that is part of a Peyer's patch. These cells have a major role in driving the immune response to antigens sampled from the intestinal lumen, and in regulating the formation of follicle-associated epithelium and M cells in Peyer's patches by converting intestitial enterocytes into M cells." ; terms:contributor ; oboInOwl:hasExactSynonym "Peyer's patch resident lymphocyte" ; oboInOwl:hasNarrowSynonym "small intestine Peyer's patch lymphocyte" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "Peyer's patch lymphocyte" ; rdfs:subClassOf obo:CL_0000542, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001211 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000542 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001211 ] ) ] . obo:CL_0009015 obo:IAO_0000115 "A follicular dendritic cell located in the Peyer's patch. These cells from a meshwork in which Peyer's patch B cells reside." ; terms:contributor ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "Peyer's patch follicular dendritic cell" ; rdfs:subClassOf obo:CL_0000442, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001211 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000442 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001211 ] ) ] . obo:CL_0009016 obo:IAO_0000115 "An intestinal stem cell that is located in the large intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the large intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasBroadSynonym "crypt stem cell of large intestine" ; oboInOwl:hasExactSynonym "stem cell of large intestine crypt of Lieberkuhn" ; oboInOwl:inSubset cl:cellxgene_subset, pato:location_grouping, core:human_reference_atlas ; a owl:Class ; rdfs:label "intestinal crypt stem cell of large intestine" ; rdfs:subClassOf obo:CL_0002250, obo:CL_0002253, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001984 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002250 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001984 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/large-intestine-crypt-lieberkuhn/v1.2/assets/2d-ftu-large-intestine-crypt-lieberkuhn.png" . obo:CL_0009017 obo:IAO_0000115 "An intestinal stem cell that is located in the small intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the small intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells." ; terms:contributor ; terms:description """Intestinal crypt stem cells of the small intestine are a type of adult stem cell intimately involved in the continuous replenishment of the intestinal epithelium, the innermost layer of the intestine responsible for nutrient absorption. These cells, located within the crypts of Lieberkühn, are the origin of various cell lineages that make up the functional units of the small intestine. They possess self-renewal ability, an essential feature of stem cells, which allows them to maintain a steady population in the small intestine. One of the critical roles of intestinal crypt stem cells is to drive the continual renewal process taking place in the small intestine every 3-5 days. By proliferating intensively, these cells produce transient amplifying (TA) cells that are characterized by quick division and progressive differentiation. These cells eventually differentiate into specialized cell types, encompassing absorptive enterocytes, mucin-secreting goblet cells, hormone-secreting enteroendocrine cells, and Paneth cells, all of which have essential roles in digestion and nutrient absorption in the small intestine. Intestinal crypt stem cells of the small intestine are also play a significant part in injury recovery. Under regular conditions, these cells primarily exist in an active state, facilitating the constant renovation of the gut lining. However, upon injury or loss of regular intestinal crypt stem cells reserve intestinal stem cells, a slow-cycling and radio-resistant population, can be stimulated to take over the duties of active crypt stem cells. Such plasticity provides a powerful regenerative mechanism that ensures the intestinal epithelium's function and structural integrity amidst diverse conditions. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasBroadSynonym "crypt stem cell of small intestine" ; oboInOwl:hasExactSynonym "stem cell of small intestine crypt of Lieberkuhn" ; oboInOwl:inSubset cl:cellxgene_subset, pato:location_grouping ; a owl:Class ; rdfs:label "intestinal crypt stem cell of small intestine" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009017" ; rdfs:subClassOf obo:CL_0002250, obo:CL_0002254, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001241 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002250 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001241 ] ) ] ; foaf:depiction . obo:CL_0009018 obo:IAO_0000115 "A lymphocyte that resides in the lamina propria of the large intestine." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasExactSynonym "lamina propria lymphocyte of large intestine" ; oboInOwl:inSubset pato:location_grouping, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "lymphocyte of large intestine lamina propria" ; rdfs:subClassOf obo:CL_0000542, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011189 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000542 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011189 ] ) ] . obo:CL_0009019 obo:IAO_0000115 "A kidney cortical cell that is part of the nephrogenic zone." ; terms:contributor ; oboInOwl:hasExactSynonym "cortical nephrogenic niche cell", "cortical nephrogenic zone cell" ; oboInOwl:inSubset cl:added_for_HCA ; a owl:Class ; rdfs:label "nephrogenic zone cell" ; rdfs:subClassOf obo:CL_0002681, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009871 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002681 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009871 ] ) ] . obo:CL_0009020 obo:IAO_0000115 "An intestinal tuft cell that is a part of a vermiform appendix." ; terms:contributor ; oboInOwl:hasExactSynonym "appendix tuft cell", "tuft cell of appendix vermiformis", "tuft cell of vermiform appendix" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "tuft cell of appendix" ; rdfs:subClassOf obo:CL_0002203, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0019032 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ) ] . obo:CL_0009021 obo:IAO_0000115 "A stromal cell found in the lamina propria of the large intestine." ; terms:contributor ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "stromal cell of lamina propria of large intestine" ; rdfs:subClassOf obo:CL_0000499, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011189 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011189 ] ) ] . obo:CL_0009022 obo:IAO_0000115 "A stromal cell found in the lamina propria of the small intestine." ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset, pato:location_grouping ; a owl:Class ; rdfs:label "stromal cell of lamina propria of small intestine" ; rdfs:subClassOf obo:CL_0000499, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001238 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001238 ] ) ] . obo:CL_0009023 obo:IAO_0000115 "A T cell which resides in the Peyer's patch of the small intestine." ; terms:contributor ; oboInOwl:hasExactSynonym "T cell of Peyer's patch of small intestine", "T cell of small intestine Peyer's patch" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "small intestine Peyer's patch T cell" ; rdfs:subClassOf obo:CL_0002419, obo:CL_0009014, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003454 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002419 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003454 ] ) ] . obo:CL_0009024 obo:IAO_0000115 "A mesothelial cell that is part of the small intestine." ; terms:contributor ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "mesothelial cell of small intestine" ; rdfs:subClassOf obo:CL_0008041, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001206 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001206 ] ) ] . obo:CL_0009025 obo:IAO_0000115 "A mesothelial cell that is part of the colon." ; terms:contributor ; oboInOwl:hasBroadSynonym "mesothelial cell of large intestine" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "mesothelial cell of colon" ; rdfs:subClassOf obo:CL_0008041, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003335 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003335 ] ) ] . obo:CL_0009026 obo:IAO_0000115 "An enterocyte that is a part of a vermiform appendix." ; terms:contributor ; oboInOwl:hasExactSynonym "appendix enterocyte", "enterocyte of appendix vermiformis", "enterocyte of vermiform appendix" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "enterocyte of appendix" ; rdfs:subClassOf obo:CL_0002071, obo:CL_1000405 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000584 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ) ] . obo:CL_0009027 obo:IAO_0000115 "A transit amplifying cell that is part of a crypt of Lieberkuhn of large intestine." ; terms:contributor ; oboInOwl:hasExactSynonym "appendix transit amplifying cell", "transit amplifying cell of appendix vermiformis", "transit amplifying cell of vermiform appendix" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "transit amplifying cell of appendix" ; rdfs:subClassOf obo:CL_0002253, obo:CL_4047017, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013486 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0009028 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4047017 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013486 ] ) ] . obo:CL_0009028 obo:IAO_0000115 "An intestinal crypt stem cell that is located in the vermiform appendix. These stem cells reside at the bottom of crypts in the appendix and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells." ; terms:contributor ; oboInOwl:hasExactSynonym "appendix intestinal crypt stem cell", "intestinal crypt stem cell of appendix vermiformis", "intestinal crypt stem cell of vermiform appendix", "stem cell of intestinal crypt of Lieberkuhn of appendix", "stem cell of intestinal crypt of Lieberkuhn of appendix vermiformis" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "intestinal crypt stem cell of appendix" ; rdfs:subClassOf obo:CL_0009016, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013486 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002250 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013486 ] ) ] . obo:CL_0009029 obo:IAO_0000115 "A mesothelial cell that is located in a vermiform appendix." ; terms:contributor ; oboInOwl:hasExactSynonym "appendix mesothelial cell", "mesothelial cell of appendix vermiformis", "mesothelial cell of vermiform appendix" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "mesothelial cell of appendix" ; rdfs:subClassOf obo:CL_0008041, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012498 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012498 ] ) ] . obo:CL_0009030 obo:IAO_0000115 "An intestinal enteroendocrine cell that is located in a vermiform appendix." ; terms:contributor ; oboInOwl:hasExactSynonym "appendix enteroendocrine cell", "enteroendocrine cell of appendix vermiformis", "enteroendocrine cell of vermiform appendix" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "enteroendocrine cell of appendix" ; rdfs:subClassOf obo:CL_1000405, obo:CL_1001516 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001516 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ) ] . obo:CL_0009031 obo:IAO_0000115 "A T cell that is located in a vermiform appendix." ; terms:contributor ; oboInOwl:hasExactSynonym "T cell of appendix vermiformis", "T cell of vermiform appendix", "appendix T cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "T cell of appendix" ; rdfs:subClassOf obo:CL_0000084, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ) ] . obo:CL_0009032 obo:IAO_0000115 "A B cell that is located in a vermiform appendix." ; terms:contributor ; oboInOwl:hasExactSynonym "B cell of appendix vermiformis", "B cell of vermiform appendix", "appendix B cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "B cell of appendix" ; rdfs:subClassOf obo:CL_0000236, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000236 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ) ] . obo:CL_0009033 obo:IAO_0000115 "A plasma cell that is located in a vermiform appendix." ; terms:contributor ; oboInOwl:hasExactSynonym "appendix plasma cell", "plasma cell of appendix vermiformis", "plasma cell of vermiform appendix" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "plasma cell of appendix" ; rdfs:subClassOf obo:CL_0000786, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000786 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ) ] . obo:CL_0009034 obo:IAO_0000115 "A dendritic cell that is located in a vermiform appendix." ; terms:contributor ; oboInOwl:hasExactSynonym "appendix dendritic cell", "dendritic cell of appendix vermiformis", "dendritic cell of vermiform appendix" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "dendritic cell of appendix" ; rdfs:subClassOf obo:CL_0000451, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000451 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ) ] . obo:CL_0009035 obo:IAO_0000115 "A stromal cell found in the lamina propria of the vermiform appendix." ; terms:contributor ; oboInOwl:hasExactSynonym "stromal cell of appendix lamina propria", "stromal cell of lamina propria of appendix vermiformis" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "stromal cell of lamina propria of vermiform appendix" ; rdfs:subClassOf obo:CL_0009021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011189 ] ) ] . obo:CL_0009036 obo:IAO_0000115 "A macrophage located in the vermiform appendix." ; terms:contributor ; oboInOwl:hasExactSynonym "macrophage of appendix", "macrophage of appendix vermiformis", "macrophage of vermiform appendix" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "appendix macrophage" ; rdfs:subClassOf obo:CL_0000235, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000235 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ) ] . obo:CL_0009037 obo:IAO_0000115 "A B lymphocyte that resides in the mantle zone of the lymph node germinal center. These are generally IgM and IgD positive activated B cells that form a 'corona' around the germinal center and are part of the establishment of a secondary lymphatic follicule." ; terms:contributor ; oboInOwl:hasBroadSynonym "mantle zone B cell" ; oboInOwl:hasExactSynonym "mantle zone B cell of lymph node" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "lymph node mantle zone B cell" ; rdfs:subClassOf obo:CL_0000236, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010420 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000236 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010420 ] ) ] . obo:CL_0009038 obo:IAO_0000115 "A macrophage that is located in the colon." ; terms:contributor ; terms:description """Colon macrophages are a heterogeneous population of macrophages in the gastrointestinal tract. Intestinal macrophages represent the largest group of macrophages in the body and play a key role as sentinels for pathogen recognition and elimination. Because the gastrointestinal tract is continually exposed to a high antigenic load derived from microbes and food intake, macrophages in the intestines are crucial not only for the gut’s immune defense but also for maintaining gastrointestinal homeostasis, avoiding chronic inflammation despite constantly facing foreign antigens. The phenotypic profiles and cytokine production of intestinal macrophages therefore differ from conventional macrophages elsewhere in the body. Colon macrophages orchestrate a wide variety of immune responses. They interact with the colon’s microflora thanks to their location in the mucosal layer, thus playing an important role in shaping gut immunity. By presenting antigens, they help to activate and steer an appropriate immune response either by triggering inflammation against harmful pathogens or by supporting tolerance for beneficial microbes. Therefore, disturbances in the colon macrophage population is thought to contribute to colon-related diseases such as inflammatory bowel disease and colon cancer. These immune cells are versatile and multifunctional, not just limited to defensive actions. Colon macrophages interact with the enteric nervous system to regulate gut secretion and motility. They also play a crucial role in maintaining colon tissue health and integrity by contributing to tissue repair processes. This occurs either through phagocytosis of dead cells and remnants, or indirectly through the release of growth factor molecules, which stimulate cellular proliferation and differentiation necessary for tissue regeneration. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasExactSynonym "macrophage of colon" ; oboInOwl:inSubset cl:cellxgene_subset, pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "colon macrophage" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009038" ; rdfs:subClassOf obo:CL_0000235, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000235 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:CL_0009039 obo:IAO_0000115 "A goblet cell that is located in the colon." ; terms:contributor ; terms:description """Colon goblet cells are a subset of intestinal goblet cells that are localized in the epithelial lining of the colon. They are specialized secretory epithelial cells that are recognized by their characteristic ‘goblet’ or flask-like shape and typically have a distinctive appearance due to the accumulation of secretory vesicles in their cytoplasm. The primary function of goblet cells is the secretion of mucus, which is an essential substance for the protection and successful functioning of the intestinal tract. In the colon, goblet cells continuously renew the inner mucus layer, which is attached and impervious to bacteria (the outer layer of the colon is unattached and is the habitat of commensal bacteria) The mucus secreted by goblet cells is rich in glycoproteins known as mucins, especially MUC2, forming a complex web of molecules that comprises the foundational structure of the mucus layer. It traps and eliminates harmful bacteria, while selectively allowing beneficial microbiota to access the epithelial surface and aid in digestion and nutrient absorption. The mucus layer not only provides a provides a protective barrier against pathogen invasion, as well as mechanical damage, and the erosive effects of digestive enzymes, it also acts as a lubricant to facilitate the passage of food material. Colon goblet cells are also involved in regulating the local immune response within the gut, maintaining the delicate balance between necessary immune reactions to harmful pathogens and tolerance to beneficial microbiota and dietary substances. Goblet cells can modulate immune responses by presenting antigens to dendritic cells, as well as through the production of immunomodulatory molecules that can alter the behavior of immune cells. When the inner mucus layer of the colon is defective, it might be a pathophysiological mechanism for colitis and infectious diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasExactSynonym "goblet cell of colon" ; oboInOwl:inSubset cl:cellxgene_subset, pato:location_grouping ; a owl:Class ; rdfs:label "colon goblet cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009039" ; rdfs:subClassOf obo:CL_0011108, obo:CL_1000320 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000397 ] ) ] . obo:CL_0009040 obo:IAO_0000115 "A stromal cell found in the lamina propria of the colon." ; terms:contributor ; oboInOwl:hasExactSynonym "stromal cell of colon lamina propria" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "stromal cell of lamina propria of colon" ; rdfs:subClassOf obo:CL_0009021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007177 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007177 ] ) ] . obo:CL_0009041 obo:IAO_0000115 "A tuft cell that is part of the colonic epithelium, primarily adapted for microbial sensing in the dense colonic microbiota. Unlike its small intestinal counterpart, it does not participate in parasite-driven tuft cell–ILC2 circuits. Instead, it detects bacterial metabolites via taste-signaling pathways (Strine and Craig, 2022). The colonic tuft cell plays a key role in epithelial repair, modulates inflammatory responses through IL-25 secretion, and contributes to intestinal homeostasis by balancing microbiome interactions (Sebastian et al., 2021)." ; terms:contributor ; terms:description """Tuft cells, also often referred to as brush cells or caveolated cells, are highly specialized sensory cells found in the colon, among other organs. They were named for their unique appearance under an electron microscope, which presents a distinctive ‘tuft-like’ morphology. They are characterized by apical microvilli, arranged in an irregular tuft that confers a dome-like shape. These cells comprise only a small fraction of the cells in the epithelial layer of the colon, making them among the least populous cell types in this region. Tuft cells in the colon primarily function as chemosensory cells that can sense and respond to environmental changes. These cells can detect and respond to microbial metabolites, helping initiate immune responses against potential threats. Recent studies have revealed that tuft cells play a role in responding to intestinal parasitic infections. When a gastrointestinal parasite infects the colon, tuft cells are activated and release the cytokine IL-25. This action increases the production of tuft cells and triggers essential Th2 immune responses to expel the parasites. Also, the removal of tuft cells has been linked to increased susceptibility to these infections. However, overactivity of tuft cells has been associated with inflammatory bowel disease, highlighting the need for a delicate balance of tuft cell function to maintain colon homeostasis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasExactSynonym "colon tuft cell" ; oboInOwl:inSubset cl:cellxgene_subset, pato:location_grouping ; a owl:Class ; rdfs:label "tuft cell of colon" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009041" ; rdfs:subClassOf obo:CL_0002203, obo:CL_0011108 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000397 ] ) ] . obo:CL_0009042 obo:IAO_0000115 "An enteroendocrine cell that is located in the colon." ; terms:contributor ; oboInOwl:hasExactSynonym "colon enteroendocrine cell" ; oboInOwl:inSubset cl:cellxgene_subset, pato:location_grouping ; a owl:Class ; rdfs:label "enteroendocrine cell of colon" ; rdfs:subClassOf obo:CL_0011108, obo:CL_1001516 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000164 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:CL_0009043 obo:IAO_0000115 "An intestinal crypt stem cell that is located in the crypt of Lieberkuhn of colon." ; terms:contributor ; terms:description """Intestinal crypt stem cells of the colon, also known as colon crypt base columnar (CBC) cells, are highly specialized cells primarily responsible for the constant self-renewal of the colonic epithelium. These cells are found in the crypts of Lieberkühn - deeply invaginated sections of the colon's mucosal layer. The prime function of intestinal crypt stem cells of the colon is to serve as the source of constant cell regeneration in the colon. Every few days, these stem cells divide and differentiate into the various other types of intestinal cells, such as enterocytes, goblet cells, and enteroendocrine cells. A constant renewal cycle is necessary due to the harsh environment of the colon where cells continuously encounter abrasive food matter and potential pathogens, leading to a high turnover rate. When the colon's mucosal layer suffers damage, a rapid response is triggered whereby colon crypt stem cells divide faster and are directed to injured sites to repair the epithelial layer. Dysregulation of these cells' function or proliferation can contribute to disorders such as colorectal cancer. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:inSubset cl:cellxgene_subset, pato:location_grouping ; a owl:Class ; rdfs:label "intestinal crypt stem cell of colon" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009043" ; rdfs:subClassOf obo:CL_0009016, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002250 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013485 ] ) ] . obo:CL_0009044 obo:IAO_0000115 "A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response." ; terms:contributor ; oboInOwl:hasBroadSynonym "gastrointestinal tract small intestine (lamina propria) leukocyte", "small intestine lamina propria leukocyte", "small intestine lamina propria leukocyte (LPL)" ; oboInOwl:hasExactSynonym "gastrointestinal tract (lamina propria) lymphocyte of small intestine", "lamina propria lymphocyte of small intestine", "small intestine lamina propria lymphocyte" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "lymphocyte of small intestine lamina propria" ; rdfs:subClassOf obo:CL_0000542, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001238 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000542 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001238 ] ) ] ; foaf:depiction . obo:CL_0009045 obo:IAO_0000115 "A B cell found in the lymph node medullary sinus." ; terms:contributor ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "B cell of medullary sinus of lymph node" ; rdfs:subClassOf obo:CL_0000236, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009744 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000236 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009744 ] ) ] . obo:CL_0009046 obo:IAO_0000115 "A T cell found in the lymph node medullary sinus." ; terms:contributor ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "T cell of medullary sinus of lymph node" ; rdfs:subClassOf obo:CL_0000084, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009744 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009744 ] ) ] . obo:CL_0009047 obo:IAO_0000115 "A macrophage found in the medullary sinus of the lymph node." ; terms:contributor ; oboInOwl:hasBroadSynonym "medullary sinus macrophage" ; oboInOwl:hasExactSynonym "lymph node medullary sinus macrophage" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "macrophage of medullary sinus of lymph node" ; rdfs:subClassOf obo:CL_0000235, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009744 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000235 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009744 ] ) ] . obo:CL_0009048 obo:IAO_0000115 "A macrophage that is located in the anorectum." ; terms:contributor ; oboInOwl:hasExactSynonym "macrophage of anorectum" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "anorectum macrophage" ; rdfs:subClassOf obo:CL_0000235, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000235 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009049 obo:IAO_0000115 "A layer of smooth muscle cells that forms the outer layer of the high endothelial venule of lymph node and pumps to allow flow of lymph fluid carrying lymphocytes." ; terms:contributor ; oboInOwl:hasBroadSynonym "high endothelial venule smooth muscle cell" ; oboInOwl:hasExactSynonym "high endothelial venule of lymph node smooth muscle cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "smooth muscle cell of high endothelial venule of lymph node" ; rdfs:subClassOf obo:CL_0008035, obo:CL_0019018, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410038 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410038 ] ) ] . obo:CL_0009050 obo:IAO_0000115 "A B cell that is located in the anorectum." ; terms:contributor ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "B cell of anorectum" ; rdfs:subClassOf obo:CL_0000236, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000236 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009051 obo:IAO_0000115 "A T cell that is located in the anorectum." ; terms:contributor ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "T cell of anorectum" ; rdfs:subClassOf obo:CL_0000084, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009052 obo:IAO_0000115 "A smooth muscle cell that is located in the anorectum." ; terms:contributor ; oboInOwl:hasExactSynonym "anorectum smooth muscle cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "smooth muscle cell of anorectum" ; rdfs:subClassOf obo:CL_1000279, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009053 obo:IAO_0000115 "A stromal cell found in the lamina propria of the anorectum." ; terms:contributor ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "stromal cell of anorectum lamina propria" ; rdfs:subClassOf obo:CL_0009021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011189 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009054 obo:IAO_0000115 "A microfold cell (M cell) that is part of the anorectum." ; terms:contributor ; oboInOwl:hasExactSynonym "M cell of anorectum" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "microfold cell of epithelium proper of anorectum" ; rdfs:subClassOf obo:CL_1000360, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000682 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009055 obo:IAO_0000115 "A paneth cell that is located in the anorectum." ; terms:contributor ; oboInOwl:hasExactSynonym "anorectum paneth cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "paneth cell of anorectum" ; rdfs:subClassOf obo:CL_0000510, obo:CL_0002658, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000510 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009056 obo:IAO_0000115 "A transit amplifying cell that is located in the anorectum." ; terms:contributor ; oboInOwl:hasExactSynonym "anorectum transit amplifying cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "transit amplifying cell of anorectum" ; rdfs:subClassOf obo:CL_0002253, obo:CL_4047017, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4047017 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009057 obo:IAO_0000115 "A goblet cell that is located in the anorectum." ; terms:contributor ; oboInOwl:hasExactSynonym "goblet cell of anorectum" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "anorectum goblet cell" ; rdfs:subClassOf obo:CL_1000320, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000320 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009058 obo:IAO_0000115 "An enterocyte that is located in the anorectum." ; terms:contributor ; oboInOwl:hasExactSynonym "anorectum enterocyte" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "enterocyte of anorectum" ; rdfs:subClassOf obo:CL_0002071, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000584 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009059 obo:IAO_0000115 "A plasma cell that is located in the medullary sinus of the lymph node." ; terms:contributor ; oboInOwl:hasBroadSynonym "medullary plasma cell", "medullary sinus plasma cell", "plasma cell of medullary sinus" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "plasma cell of medullary sinus of lymph node" ; rdfs:subClassOf obo:CL_0000786, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009744 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000786 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009744 ] ) ] . obo:CL_0009060 obo:IAO_0000115 "A mature B cell located in the marginal zone of the lymph node." ; terms:contributor ; oboInOwl:hasBroadSynonym "marginal zone B cell" ; oboInOwl:hasExactSynonym "lymph node marginal zone B cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "marginal zone B cell of lymph node" ; rdfs:subClassOf obo:CL_0000785, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410065 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410065 ] ) ] . obo:CL_0009061 obo:IAO_0000115 "An intestinal crypt stem cell that is located in the anorectum." ; terms:contributor ; oboInOwl:hasExactSynonym "anorectum intestinal crypt stem cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "intestinal crypt stem cell of anorectum" ; rdfs:subClassOf obo:CL_0009016, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0009016 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009062 obo:IAO_0000115 "A specialized type of CD4 positive T cell, the follicular helper T cell (TFH cell), that upregulates CXCR5 expression to enable its follicular localization. These specialised T cells reside in the germinal center of the lymph node." ; terms:contributor ; oboInOwl:hasExactSynonym "T follicular helper cell of germinal center of lymph node", "T follicular helper cell of lymph node germinal center", "lymph node germinal center T follicular helper cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "germinal center T cell" ; rdfs:subClassOf obo:CL_0002038, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009039 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002038 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009039 ] ) ] . obo:CL_0009063 obo:IAO_0000115 "An enteroendocrine cell that is located in the anorectum." ; terms:contributor ; oboInOwl:hasExactSynonym "anorectum enteroendocrine cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "enteroendocrine cell of anorectum" ; rdfs:subClassOf obo:CL_0002253, obo:CL_1001516, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000164 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009064 obo:IAO_0000115 "A T cell located in the lymph node paracortex, where macrophages and dendritic cells present antigenic peptides to these naïve T cells, stimulating them to become activated helper T cells or cytotoxic T lymphocytes." ; terms:contributor ; oboInOwl:hasBroadSynonym "paracortex T cell", "paracortical T cell" ; oboInOwl:hasExactSynonym "T cell of lymph node paracortex" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "lymph node paracortex T cell" ; rdfs:subClassOf obo:CL_0000084, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410066 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410066 ] ) ] . obo:CL_0009065 obo:IAO_0000115 "An intestinal tuft cell that is located in the anorectum." ; terms:contributor ; oboInOwl:hasExactSynonym "anorectum tuft cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "tuft cell of anorectum" ; rdfs:subClassOf obo:CL_0002203, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0019032 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009066 obo:IAO_0000115 "A stratified squamous epithelial cell that is part of the anal canal." ; terms:contributor ; oboInOwl:hasExactSynonym "anal canal stratified squamous epithelial cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "stratified squamous epithelial cell of anal canal" ; rdfs:subClassOf obo:CL_0000240, obo:CL_0002253, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0015716 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000240 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0015716 ] ) ] . obo:CL_0009067 obo:IAO_0000115 "An enterocyte found in the small intestine of newborn mammals and characterized by the presence of an apical canalicular system (ACS) leading to production of large vacuoles, important for colostral macromolecule uptake. After birth, the vacuolated fetal-type enterocytes are replaced with enterocytes lacking an ACS." ; terms:contributor ; oboInOwl:hasBroadSynonym "vacuolated enterocyte" ; oboInOwl:hasRelatedSynonym "early enterocyte", "immature enterocyte" ; a owl:Class ; rdfs:label "vacuolated fetal-type enterocyte" ; rdfs:subClassOf obo:CL_0000584, obo:CL_0002254, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_40674 ] . obo:CL_0009068 obo:IAO_0000115 "An unconventional T lymphocyte population within the thymic medulla that is potentially a thymic resident population." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "CD8aa(I) thymocyte" ; rdfs:subClassOf obo:CL_0000893, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002124 ] . obo:CL_0009069 obo:IAO_0000115 "An unconventional T lymphocyte population within the thymic medulla that expresses both alpha/beta and gamma/delta T cell signatures." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "CD8aa(II) thymocyte" ; rdfs:subClassOf obo:CL_0000893, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002124 ] . obo:CL_0009070 obo:IAO_0000115 "A thymic epithelial cell located at the corticomedullary junction." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "corticomedullary thymic epithelial cell" ; rdfs:subClassOf obo:CL_0002293, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003988 ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" . obo:CL_0009071 obo:IAO_0000115 "A thymic medullary epithelial cell considered to be a pre-AIRE mTEC population." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "medullary thymic epithelial cell type 1" ; rdfs:subClassOf obo:CL_0002365, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003846 ] . obo:CL_0009072 obo:IAO_0000115 "A thymic medullary epithelial cell that expresses AIRE or other canonical markers of mature mTECs like Fezf2." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "medullary thymic epithelial cell type 2" ; rdfs:subClassOf obo:CL_0002365, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003846 ] . obo:CL_0009073 obo:IAO_0000115 "A thymic medullary epithelial cell considered to be a post-AIRE cell. This group of AIRE-mTECs is heterogeneous and also includes mTECs within Hassall's Corpuscles." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasExactSynonym "corneocyte-like mTECs", "corneocyte-like medullary thymic epithelial cell", "post-Aire cell" ; oboInOwl:hasRelatedSynonym "mTEC III" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "medullary thymic epithelial cell type 3" ; rdfs:subClassOf obo:CL_0002365, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003846 ] . obo:CL_0009074 obo:IAO_0000115 "A thymic medullary epithelial cell that expresses typical tuft cell markers instead of classical mTEC or cTEC markers. This population has a bulbous-like structure." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasBroadSynonym "thymic tuft cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "medullary thymic epithelial cell type 4" ; rdfs:subClassOf obo:CL_0002365, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003846 ] . obo:CL_0009075 obo:IAO_0000115 "A thymic medullary epithelial cell that expresses muscle-specific biomarkers." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "myo-medullary thymic epithelial cell" ; rdfs:subClassOf obo:CL_0002365, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003846 ] . obo:CL_0009076 obo:IAO_0000115 "A thymic medullary epithelial cell that expresses neuroendocrine biomarkers." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "neuro-medullary thymic epithelial cell" ; rdfs:subClassOf obo:CL_0002365, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003846 ] . obo:CL_0009077 obo:IAO_0000115 "A thymic epithelial cell located within the subcapsular region of the thymus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "subcapsular thymic epithelial cell" ; rdfs:subClassOf obo:CL_0002364, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006936 ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" . obo:CL_0009078 obo:IAO_0000115 "A fibroblast located in the thymic capsule." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasExactSynonym "thymic capsular fibroblast" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "thymic fibroblast type 1" ; rdfs:subClassOf obo:CL_0000057, obo:CL_4030001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002122 ] . obo:CL_0009079 obo:IAO_0000115 "A fibroblast located between thymic lobules." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasExactSynonym "thymic interlobular fibroblast" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "thymic fibroblast type 2" ; rdfs:subClassOf obo:CL_0000057, obo:CL_4030001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004791 ] . obo:CL_0009080 obo:IAO_0000115 "A tuft cell located in the small intestine." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasExactSynonym "brush cell of epithelium of small intestine", "brush cell of epithelium proper of small intestine", "brush cell of small intestine", "tuft cell of epithelium of small intestine" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "tuft cell of small intestine" ; rdfs:subClassOf obo:CL_0002254, obo:CL_0019032, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001902 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0019032 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] ; foaf:depiction , "https://cdn.humanatlas.io/digital-objects/2d-ftu/small-intestine-villus/v1.0/assets/2d-ftu-small-intestine-villus.png" . obo:CL_0009081 obo:IAO_0000115 "The human equivalent of a DN2 thymocyte; typically contains two phases, in the latter of which these thymocytes begin the process of beta selection." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2021-11-25T09:26:32Z"^^xsd:dateTime ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in human versus mouse thymus. This term is restricted for use with human data." ; rdfs:label "specified double negative thymocyte (Homo sapiens)" ; rdfs:subClassOf obo:CL_0002489, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] . obo:CL_0009082 obo:IAO_0000115 "The human equivalent of a DN3 thymocyte; these thymocytes finish the process of beta selection." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2021-11-25T09:30:45Z"^^xsd:dateTime ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in human versus mouse thymus. This term is restricted for use with human data." ; rdfs:label "committed double negative thymocyte (Homo sapiens)" ; rdfs:subClassOf obo:CL_0002489, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] . obo:CL_0009083 obo:IAO_0000115 "The human equivalent of a DN4 thymocyte." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2021-11-25T09:32:13Z"^^xsd:dateTime ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in human versus mouse thymus. This term is restricted for use with human data." ; rdfs:label "rearranging double negative thymocyte (Homo sapiens)" ; rdfs:subClassOf obo:CL_0002489, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] . obo:CL_0009084 obo:IAO_0000115 "An epithelial cell that is part of an endometrium glandular epithelium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2021-11-30T16:13:30Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0010710" ; oboInOwl:hasExactSynonym "endometrial glandular epithelial cell", "epithelial cell of endometrial gland" ; oboInOwl:inSubset pato:location_grouping, core:human_reference_atlas ; a owl:Class ; rdfs:label "glandular epithelial cell of endometrium" ; rdfs:subClassOf obo:CL_0002149, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012276 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012276 ] ) ] . obo:CL_0009085 obo:IAO_0000115 "An adult endothelial progenitor cell characterised in vivo by homing to ischemic sites and paracrine support of angiogenesis. They may form discrete colonies." ; terms:contributor ; terms:date "2022-02-18T09:55:33Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "CFU-Hill" ; a owl:Class ; rdfs:label "colony forming unit – Hill cell" ; rdfs:subClassOf obo:CL_0002619 . obo:CL_0009086 obo:IAO_0000115 "An endothelial cell that is part of a respiratory system lymphatic vessel." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2021-12-03T14:00:44Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0010667" ; oboInOwl:inSubset cl:cellxgene_subset, pato:location_grouping, core:human_reference_atlas ; a owl:Class ; rdfs:label "endothelial cell of respiratory system lymphatic vessel" ; rdfs:subClassOf obo:CL_0002138, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003529 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003456 ] ) ] . obo:CL_0009087 obo:IAO_0000115 "An extravillous trophoblast that is polynuclear." ; terms:contributor ; terms:date "2021-12-03T14:37:32Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0010712" ; oboInOwl:hasExactSynonym "fused EVT" ; a owl:Class ; rdfs:label "fused extravillous trophoblast" ; rdfs:subClassOf obo:CL_0008036 . obo:CL_0009088 obo:IAO_0000115 "An adult endothelial progenitor cell characterised in vivo by homing to ischemic sites and paracrine support of angiogenesis. These cells do not form colonies." ; terms:contributor ; terms:date "2022-02-18T10:12:57Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "circulating angiogenic cell" ; rdfs:subClassOf obo:CL_0002619 . obo:CL_0009089 obo:IAO_0000115 "A pericyte cell that is part of a lung." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2021-12-03T17:13:33Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0010669" ; oboInOwl:hasExactSynonym "lung pericyte cell", "pulmonary pericyte" ; oboInOwl:inSubset cl:cellxgene_subset, pato:location_grouping, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The marker set HIGD1B, KCNK3 can identify the Human cell type lung pericyte in the lung with a confidence of 0.84 (NS-Forest FBeta value)." ; rdfs:label "lung pericyte" ; rdfs:subClassOf obo:CL_0000669, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000047 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000669 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" . obo:CL_0009090 obo:IAO_0000115 "An adult endothelial progenitor cell that is resident of adult vasculature and capable of differentiating to regenerate endothelial cell populations. Endothelial colony forming cells are characterised in vivo by clonal proliferative status, de novo vessel formation, homing to ischemic sites and paracrine support of angiogenesis. These cells are phenotypically similar to endothelial cells." ; terms:contributor ; terms:date "2022-02-18T10:15:32Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "ECFC" ; a owl:Class ; rdfs:label "endothelial colony forming cell" ; rdfs:subClassOf obo:CL_0002619, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004537 ] . obo:CL_0009091 obo:IAO_0000115 "A stem cell found in the interstitial compartment of the neonatal testis; it is capable of self-renewal as well as differentiation into steroidogenic cells (adult Leydig cells). Intermediate stages of development include progenitor Leydig cells and immature Leydig cells." ; terms:contributor ; terms:date "2022-02-18T14:09:25Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "stem Leydig cell" ; a owl:Class ; rdfs:label "Leydig stem cell" ; rdfs:subClassOf obo:CL_0000034, obo:CL_4030031, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005212 ] . obo:CL_0009092 obo:IAO_0000115 "An endothelial cell that is part of a placenta." ; terms:contributor ; terms:date "2021-12-13T13:53:01Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0010708" ; oboInOwl:hasExactSynonym "placental endothelial cell" ; oboInOwl:inSubset cl:cellxgene_subset, pato:location_grouping ; a owl:Class ; rdfs:label "endothelial cell of placenta" ; rdfs:subClassOf obo:CL_0000115, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:CL_0009093 obo:IAO_0000115 "A smooth muscle cell that is part of a placenta." ; terms:contributor ; terms:date "2021-12-13T13:56:42Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0010709" ; oboInOwl:hasExactSynonym "placental smooth muscle cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "smooth muscle cell of placenta" ; rdfs:subClassOf obo:CL_0000192, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:CL_0009094 obo:IAO_0000115 "An endothelial cell that is part of a hepatic portal vein." ; terms:contributor ; terms:date "2021-12-13T14:01:05Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "portal endothelial cell" ; oboInOwl:hasDbXref "EFO:0010704" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "endothelial cell of hepatic portal vein" ; rdfs:subClassOf obo:CL_0002543, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001639 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001639 ] ) ] . obo:CL_0009095 obo:IAO_0000115 "An endothelial cell that is part of a uterus." ; terms:contributor ; terms:date "2021-12-13T14:39:25Z"^^xsd:dateTime ; terms:description """The endothelial cell of the uterus is a specialized type of endothelial cell found in the inner lining of blood vessels, specifically those in the uterus. These cells play critical roles in maintaining uterine health, fertilization, and pregnancy processes. They form the interior surface of blood vessels, creating a barrier between the vessel lumen and surrounding tissue. This fluid environment, maintained by these endothelial cells, provides a platform for the material exchange between blood and tissues, thereby modulating blood coagulation, immune responses, and controlling vasodilation and vasoconstriction. Functionally, the endothelial cells of the uterus are paramount in regulating the uterine blood flow, an important determinant of successful conception and pregnancy outcomes. They support the vascular changes during the reproductive cycle, particularly the spiral arteriolar development and function, essential in endometrial thickening, maturation, and eventual shedding during menstruation periods. The cells also contribute to angiogenesis, a process crucial during implantation and placenta development, whereby new blood vessels form from pre-existing vessels to supply the growing fetus with oxygen and nutrients. Uterine endothelial cells are also implicated in mediating immune responses within the uterus. Changes in these cells can influence various conditions such as reproductive disorders and complications including heavy menstrual bleeding, endometrial hyperplasia, fertility problems, and cancer. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "EFO:0010711" ; oboInOwl:hasExactSynonym "uterine endothelial cell" ; oboInOwl:inSubset cl:cellxgene_subset, pato:location_grouping ; a owl:Class ; rdfs:label "endothelial cell of uterus" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009095" ; rdfs:subClassOf obo:CL_0000115, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ) ] . obo:CL_0009096 obo:IAO_0000115 "Any cell that is part of the esophageal non-keratinized stratified squamous epithelium. In humans, the esophagus, which requires flexibility to accommodate swallowing of a bolus, is covered with a non-keratinized epithelium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-02-21T15:00:13Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "esophageal non-keratinized squamous epithelial cell", "esophageal nonkeratinized squamous epithelial cell", "esophagus non-keratinizing squamous epithelial cell", "esophagus nonkeratinizing squamous epithelial cell", "non-keratinized squamous epithelial cell of esophagus", "non-keratinizing squamous epithelial cell of esophagus", "nonkeratinized squamous epithelial cell of esophagus", "nonkeratinizing squamous epithelial cell of esophagus" ; a owl:Class ; rdfs:label "esophagus non-keratinized squamous epithelial cell" ; rdfs:subClassOf obo:CL_0000238, obo:CL_0002252, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006920 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000238 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006920 ] ) ] . obo:CL_0009097 obo:IAO_0000115 "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development." ; terms:contributor ; terms:date "2022-02-21T15:39:10Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "embryonic skeletal muscle fiber" ; rdfs:subClassOf obo:CL_0008002, [ a owl:Restriction ; owl:onProperty obo:RO_0002491 ; owl:someValuesFrom obo:UBERON_0000068 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0008002 [ a owl:Restriction ; owl:onProperty obo:RO_0002491 ; owl:someValuesFrom obo:UBERON_0000068 ] ) ] . obo:CL_0009098 obo:IAO_0000115 "A skeletal muscle fiber found at the fetal and neonatal stages. In mammalian fetuses and neonates, skeletal muscle expresses myosin heavy chain-neonatal (MyHC-neo, encoded by the MYH8 gene). This expression disappears shortly after birth and is replaced by expression of adult heavy chain myosins." ; terms:contributor ; terms:date "2022-02-21T15:43:16Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "fetal and neonatal skeletal muscle fiber" ; rdfs:subClassOf obo:CL_0008002, [ a owl:Restriction ; owl:onProperty obo:RO_0002488 ; owl:someValuesFrom obo:UBERON_0000092 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0007221 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0008002 [ a owl:Restriction ; owl:onProperty obo:RO_0002488 ; owl:someValuesFrom obo:UBERON_0000092 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0007221 ] ) ] . obo:CL_0009099 obo:IAO_0000115 "A progenitor cell that is a tissue-resident mesenchymal cell, important for skeletal muscle regeneration, and able to differentiate into both adipocytes or fibroblasts." ; terms:contributor ; terms:date "2022-02-21T16:50:02Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "fibro/adipogenic progenitor" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "fibro/adipogenic progenitor cell" ; rdfs:subClassOf obo:CL_0008019, obo:CL_0011026 . obo:CL_0009100 obo:IAO_0000115 "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-03-17T12:00:44Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "portal fibroblast" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "hepatic portal fibroblast" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001279 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001279 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" . obo:CL_0009101 obo:IAO_0000115 "A reticular cell involved in directing B cells and T cells to specific regions within a tissue." ; terms:contributor ; terms:date "2022-03-21T15:20:33Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "FRC" ; a owl:Class ; rdfs:label "fibroblastic reticular cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" ; rdfs:subClassOf obo:CL_0000186, obo:CL_0000432 . obo:CL_0009102 obo:IAO_0000115 "A specialized, fibroblastic reticular cell of mesenchymal origin found in lymph nodes. In human, it expresses several markers common to myofibroblasts (desmin, vimentin, CD73, CD90, α-smooth muscle actin (αSMA)), and can be differentiated from endothelial cells by its lack of CD31 expression. These cells are critical for the overall organization and function of the lymph node. Lymph node fibroblastic reticular cells (FRCs) can be further classified based on their location, function, and unique marker expression." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-03-21T15:24:01Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "fibroblastic reticular cell" ; a owl:Class ; rdfs:label "lymph node fibroblastic reticular cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" ; rdfs:subClassOf obo:CL_0009101, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0009101 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] ) ] . obo:CL_0009103 obo:IAO_0000115 "A fibroblastic reticular cell found in the lymph node subcapsular sinus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-03-21T15:59:56Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "marginal reticular cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lymph node marginal reticular cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" ; rdfs:subClassOf obo:CL_0009102, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0005463 ] . obo:CL_0009104 obo:IAO_0000115 "A fibroblastic reticular cell found in the lymph node germinal center dark zone (B cell zone)." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-03-21T16:55:46Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "lymph node germinal center dark zone fibroblastic reticular cell" ; oboInOwl:hasRelatedSynonym "T-B boundary reticular cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "B cell zone reticular cells share similarities with Ch25h-expresssing Ccl19lo T reticular cells found at the B cell follicle T zone interface of mouse lymph nodes." ; rdfs:label "B cell zone reticular cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" ; rdfs:subClassOf obo:CL_0009102, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410053 ] . obo:CL_0009105 obo:IAO_0000115 "A fibroblastic reticular cell found in the lymph node T cell domain." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-03-21T17:19:56Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "lymph node T cell domain fibroblastic reticular cell" ; oboInOwl:hasRelatedSynonym "interfollicular reticular cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "T cell zone reticular cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" ; rdfs:subClassOf obo:CL_0009102, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010417 ] . obo:CL_0009106 obo:IAO_0000115 "A specialized fibroblast found in the medulla of lymph node." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-03-22T09:03:15Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "lymph node medullary reticular cell", "medullary reticular cell of lymph node" ; oboInOwl:hasRelatedSynonym "MedRC" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Origin and phenotype of medullary reticular cells are less well understood in humans than in mice." ; rdfs:label "medullary reticular cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" ; rdfs:subClassOf obo:CL_0009102, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002007 ] . obo:CL_0009107 obo:IAO_0000115 "A lymphatic endothelial cell located in the subcapsular sinus ceiling of a lymph node. In human, it's characterized by a unique marker expression (NT5e+ and Caveolin-1+)." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-03-22T10:30:28Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "lymphatic endothelial cell of subcapsular sinus ceiling of lymph node" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "lymphatic endothelial cell of subcapsular sinus ceiling" ; rdfs:subClassOf obo:CL_0009115, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410071 ] . obo:CL_0009108 obo:IAO_0000115 "A lymphatic endothelial cell located in the subcapsular sinus floor of a lymph node. In human, it's characterized by a unique marker expression (TNFRSF9+)." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-03-22T10:39:28Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "lymphatic endothelial cell of subcapsular sinus floor of lymph node" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "lymphatic endothelial cell of subcapsular sinus floor" ; rdfs:subClassOf obo:CL_0009115, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410072 ] . obo:CL_0009109 obo:IAO_0000115 "A lymphatic endothelial cell located in a lymph node trabecula." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-03-23T15:08:44Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "lymphatic endothelial cell of lymph node trabecula", "lymphatic endothelial cell of trabeculae" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lymphatic endothelial cell of trabecula" ; rdfs:subClassOf obo:CL_0009115, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002195 ] . obo:CL_0009110 obo:IAO_0000115 "A lymphatic endothelial cell located in the ceiling part of a lymph node medulla." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-03-23T15:13:30Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "lymphatic endothelial cell of lymph node medulla ceiling" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "lymphatic endothelial cell of medulla ceiling" ; rdfs:subClassOf obo:CL_0009115, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002007 ] . obo:CL_0009111 obo:IAO_0000115 "A germinal center B cell found in a lymph node germinal center light zone." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-03-24T09:03:44Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "lymph node centrocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "centrocyte" ; rdfs:subClassOf obo:CL_0000844, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410052 ] . obo:CL_0009112 obo:IAO_0000115 "A germinal center B cell found in a lymph node germinal center dark zone." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-03-24T09:12:41Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "lymph node centroblast" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "centroblast" ; rdfs:subClassOf obo:CL_0000844, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410053 ] . obo:CL_0009113 obo:IAO_0000115 "A regulatory T cell present in the B cell follicles and germinal centers of lymphoid tissues. In humans, it is CXCR5+." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-03-24T09:36:29Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "follicular regulatory T cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "T follicular regulatory cell" ; rdfs:subClassOf obo:CL_0000815, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001744 ] . obo:CL_0009114 obo:IAO_0000115 """A B cell found in the perisinusoidal area of a lymph node. In humans, monocytoid B cells are a morphologically distinct B cell population (oval nuclei, abundant cytoplasm, monocyte-like appearance), share many similarities with marginal zone B cells including marker expression, and are increased in disease settings.""" ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-03-24T10:18:12Z"^^xsd:dateTime ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "monocytoid B cell" ; rdfs:subClassOf obo:CL_0000236, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410066 ] . obo:CL_0009115 obo:IAO_0000115 "An endothelial cell located in a lymph node lymphatic vessel." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "lymph node lymphatic vessel endothelial cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" ; rdfs:subClassOf obo:CL_0002138, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001473 ] ) ] . obo:CL_0009116 obo:IAO_0000115 "A progenitor cell with the potential to differentiate into luminal epithelial cells of mammary glands. In mouse, CD61 and c-kit were found to be coexpressed by the majority of, but not all, committed luminal progenitor cells." ; terms:contributor ; oboInOwl:hasBroadSynonym "luminal progenitor cell" ; oboInOwl:hasExactSynonym "progenitor cell of luminal mammary epithelium" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "progenitor cell of mammary luminal epithelium" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] . obo:CL_0010000 obo:IAO_0000115 "A hair follicle matrix region cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the hair bulb to become the hair medulla cortex and hair root sheath." ; a owl:Class ; rdfs:label "keratinized cell of hair follicle" ; rdfs:subClassOf obo:CL_2000092, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005933 ] . obo:CL_0010001 obo:IAO_0000115 "A stromal cell that is part_of a bone marrow." ; terms:contributor ; oboInOwl:hasExactSynonym "bone marrow stromal cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "stromal cell of bone marrow" ; rdfs:subClassOf obo:CL_0000499, obo:CL_0002092 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] ) ] . obo:CL_0010002 obo:IAO_0000115 "An epithelial cell that is part_of a umbilical artery." ; terms:contributor ; oboInOwl:hasExactSynonym "umbilical artery epithelial cell" ; a owl:Class ; rdfs:label "epithelial cell of umbilical artery" ; rdfs:subClassOf obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001310 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001310 ] ) ] . obo:CL_0010003 obo:IAO_0000115 "OBSOLETE. An epithelial cell that is part_of a alveolus of lung." ; obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000322 ; terms:contributor ; oboInOwl:hasDbXref "MESH:D056809" ; oboInOwl:hasExactSynonym "alveolus of lung epithelial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "This cell type is exactly the same as 'pulmonary alveolar epithelial cell'." ; rdfs:label "obsolete epithelial cell of alveolus of lung" ; owl:deprecated true . obo:CL_0010004 obo:IAO_0000115 "A mononuclear cell that is part_of a bone marrow." ; terms:contributor ; oboInOwl:hasExactSynonym "bone marrow mononuclear cell" ; a owl:Class ; rdfs:label "mononuclear cell of bone marrow" ; rdfs:subClassOf obo:CL_0000842, obo:CL_1001610 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] ) ] . obo:CL_0010005 obo:IAO_0000115 "A specialized cardiomyocyte that transmit signals from the AV node to the cardiac Purkinje fibers." ; oboInOwl:hasExactSynonym "AV bundle cell" ; a owl:Class ; rdfs:label "atrioventricular bundle cell" ; rdfs:subClassOf obo:CL_0010007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002353 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002353 ] ) ] . obo:CL_0010006 obo:IAO_0000115 "Any blood vessel endothelial cell that is part of some heart." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cardiac blood vessel endothelial cell" ; rdfs:subClassOf obo:CL_0000071, obo:CL_0010008 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000071 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:CL_0010007 obo:IAO_0000115 "Any cell that is part of some His-Purkinje system." ; a owl:Class ; rdfs:label "His-Purkinje system cell" ; rdfs:subClassOf obo:CL_0002494, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004146 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004146 ] ) ] . obo:CL_0010008 obo:IAO_0000115 "Any endothelial cell that is part of some heart." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Cardiac endothelial cells are a specialized subset of endothelial cells, the cell type responsible for forming the inner lining of cardiovascular structures such as the heart, and blood vessels. They are a pivotal component of the heart's microenvironment and play a key role in regulating blood pressure, maintaining cardiac homeostasis, in addition to cooperating with other cardiac cells like cardiomyocytes and fibroblasts in the orchestration of a coordinated heart function. Cardiac endothelial cells contribute to the each stage of the heart's operation, whether during relaxation or contraction. Cardiac endothelial cells release nitric oxide, a potent vasodilator that regulates blood vessel dilation consequently controlling blood pressure and flow. They also produce a myriad of growth factors that aid in new blood vessel formation, known as angiogenesis, crucially needed for tissue repair and regeneration when the heart undergoes damage, as in cases of myocardial infarction. Furthermore, cardiac endothelial cells control the passage of nutrients, hormones, and gases between the bloodstream and the heart tissue, ensuring its complex metabolic demands are met adequately. They serve as a selective barrier, regulating the transit of cells and signaling molecules, thereby playing a pivotal role in inflammatory responses and immune cell trafficking. They also contribute to the maintenance of blood fluidity and clotting balance through a complex interplay of anti-thrombic and pro-thrombic factors. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "cardiac endothelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0010008" ; rdfs:subClassOf obo:CL_0000115, obo:CL_0002494, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:CL_0010009 obo:IAO_0000115 "Any photoreceptor cell that is part of some camera-type eye." ; oboInOwl:hasExactSynonym "camera type eye photoreceptor cell" ; a owl:Class ; rdfs:label "camera-type eye photoreceptor cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000287, obo:CL_0009004, _:genid11713 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000210 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ] ) ] ; skos:prefLabel "camera-type eye photoreceptor cell" . obo:CL_0010010 obo:IAO_0000115 "A GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell receives excitatory inputs primarily from parallel fibers and plays a crucial role in feed-forward inhibition by suppressing the activity of Purkinje cells and modulating the output of the cerebellar cortex. The stellate cell is part of the local circuitry that contributes to the fine-tuning of motor coordination and a regulator of cerebellar blood flow via neurovascular coupling." ; oboInOwl:hasRelatedSynonym "cerebellar SC" ; a owl:Class ; rdfs:label "cerebellar stellate cell" ; rdfs:subClassOf obo:CL_0000691, obo:CL_4042035 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000122 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002974 ] ) ] ; foaf:depiction , . obo:CL_0010011 obo:IAO_0000115 "A GABAergic interneuron whose soma is located in the cerebral cortex." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cerebral cortex GABAergic interneuron" ; rdfs:subClassOf obo:CL_0008031, obo:CL_0011005 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011005 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] . obo:CL_0010012 obo:IAO_0000115 "A CNS neuron of the cerebral cortex." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasDbXref "BTO:0004102", "FMA:84104" ; oboInOwl:hasExactSynonym "cortical neuron", "neuron of cerebral cortex" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "cerebral cortex neuron" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/1359" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0012001, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] ; skos:prefLabel "cerebral cortex neuron" . obo:CL_0010013 oboInOwl:hasExactSynonym "light pinealocyte" ; a owl:Class ; rdfs:label "type I pinealocyte" ; rdfs:subClassOf obo:CL_0000652 . obo:CL_0010014 oboInOwl:hasExactSynonym "dark pinealocyte" ; a owl:Class ; rdfs:label "type II pinealocyte" ; rdfs:subClassOf obo:CL_0000652 . obo:CL_0010015 obo:IAO_0000115 "A highly specialized cell type exclusive to and forming neuroepithelium of the Saccus vasculosus, covering the caudal diverticulum of the infundibular recess." ; a owl:Class ; rdfs:comment "Editor note: remember to link to Saccus vasculosus in next uberon release" ; rdfs:label "coronet cell" ; rdfs:subClassOf obo:CL_0000066 . obo:CL_0010016 obo:IAO_0000115 "A cell with a flagellum surrounded by a collar of microvilli. The motion of the flagellum draws water past the microvilli, serving either a feeding or sensory function. Collar cells are found in multiple animals, including sponges, echinoderms, and cnidarians. They are also found outside animals in the choanoflagellates. Although collar cells are superficially similar, their cytoskeletal structure and functional biology are different in different groups of organisms." ; a owl:Class ; rdfs:label "collar cell" ; rdfs:subClassOf obo:CL_0000064 . obo:CL_0010017 obo:IAO_0000115 "A zygote in a plant or an animal." ; oboInOwl:hasDbXref "MESH:D015053" ; a owl:Class ; rdfs:label "zygote"@en ; rdfs:seeAlso ; rdfs:subClassOf obo:CL_0000000 ; skos:prefLabel "zygote" . obo:CL_0010020 obo:IAO_0000115 "Any glial cell that is part of some heart." ; a owl:Class ; rdfs:label "cardiac glial cell" ; rdfs:subClassOf obo:CL_0000125, obo:CL_0002494, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:CL_0010021 obo:IAO_0000115 "Any myoblast that develops into some cardiac muscle cell." ; oboInOwl:hasDbXref "MESH:D032386" ; a owl:Class ; rdfs:label "cardiac myoblast" ; rdfs:subClassOf obo:CL_0000056, [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000746 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000056 [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000746 ] ) ] . obo:CL_0010022 obo:IAO_0000115 "A neuron that has its soma in the heart." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "This term is used in 3 GO terms that were created as part of the heart development focus project." ; rdfs:label "cardiac neuron" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/pull/1488" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000032, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000948 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000032 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:CL_0011000 obo:IAO_0000115 "A CNS interneuron located in the dorsal horn of the spinal cord." ; oboInOwl:hasRelatedSynonym "dorsal spinal cord interneuron" ; a owl:Class ; rdfs:label "dorsal horn interneuron" ; rdfs:subClassOf obo:CL_0002611, obo:CL_0005000 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002256 ] ) ] . obo:CL_0011001 obo:IAO_0000115 "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "spinal cord motor neuron" ; rdfs:subClassOf obo:CL_0000100, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002240 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000100 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:CL_0011002 obo:IAO_0000115 "A motor neuron that is generated only on limb levels and send axons into the limb mesenchyme." ; a owl:Class ; rdfs:comment "Need to MIREOT in 'spinal cord lateral column' from Uberon" ; rdfs:label "lateral motor column neuron" ; rdfs:subClassOf obo:CL_0011001 . obo:CL_0011003 obo:IAO_0000115 "A neurosecretory neuron residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, that is capable of secreting the hormones oxytocin or vasopressin, and sometimes both, into the systemic circulation." ; terms:contributor ; oboInOwl:hasDbXref "ILX:0107463" ; oboInOwl:hasExactSynonym "magnocellular neuron" ; a owl:Class ; rdfs:label "magnocellular neurosecretory cell" ; rdfs:subClassOf obo:CL_0000165, obo:CL_0012001, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001898 ] . obo:CL_0011004 obo:IAO_0000115 "A vetebrate lens cell that is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Lens fiber cells are specialized, elongated cells located in the ocular lens, an important part of the eye responsible for focusing light onto the retina to create clear defined images. These cells are unique among body cells, as they are transparent and filled with a clear protein called crystallin to facilitate the passage of light. The entire life cycle of a lens fiber cell includes differentiation from lens epithelial cells, which are the progenitor cells lying at the anterior surface of the lens. In response to various signals, these cells elongate and migrate towards the posterior pole, while simultaneously undergoing a process of denucleation and degradation of cellular organelles. This unique process ensures that the cells do not scatter light, which is critical for the transparency of the lens. After reaching full maturity, lens fiber cells form tightly packed layers, known as laminae, to make up the distinctive architecture of the ocular lens. Lens fiber cells play pivotal roles in vision. Their primary function is to transmit and focus the light that enters the eye onto the retina, providing the sharpness and clarity necessary for vision. The precise alignment and organization of these cells allow for optimal light transmittance and minimizes scattering, thereby maintaining the transparency of the lens. As such, disruptions or abnormalities in lens fiber cells can lead to serious vision impairment, including conditions like cataracts, a common condition characterized by the opacification of the lens. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "ZFA:0009401" ; oboInOwl:hasExactSynonym "lens fibre cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "lens fiber cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0011004" ; rdfs:subClassOf obo:CL_0002222 . obo:CL_0011005 obo:IAO_0000115 "An interneuron that uses GABA as a vesicular neurotransmitter. These interneurons are inhibitory" ; oboInOwl:hasExactSynonym "GABAergic inhibitory interneuron" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "The formal and textual definitions of this term will need to be altered if evidence for non-inhibitory GABA-ergic neurons emerges." ; rdfs:label "GABAergic interneuron" ; rdfs:subClassOf obo:CL_0000498, obo:CL_0000617 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ) ] ; skos:prefLabel "GABAergic interneuron" . obo:CL_0011006 obo:IAO_0000115 "A cerebellar interneuron characterized by a spindle-shaped or triangular soma, parasagittally oriented and located at the border between the granular layer and the Purkinje cell layer. The Lugaro cell extends dendrites predominantly in the parasagittal plane, forming synaptic interactions with basket, stellate, and Golgi cells. Its axonal projections extend upward into the molecular layer, where they form a parasagittal plexus and emit long transverse collaterals that run parallel to the long axis of the cerebellar folia. The Lugaro cell is capable of co-releasing GABA and glycine, as evidenced by the expression of glutamate decarboxylase (GAD65/67) and the glycine transporter GlyT2." ; oboInOwl:hasRelatedSynonym "globular cell" ; a owl:Class ; rdfs:label "Lugaro cell" ; rdfs:subClassOf obo:CL_0008059, obo:CL_4023057, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002956 ] ; foaf:depiction , . obo:CL_0011007 obo:IAO_0000115 "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites." ; oboInOwl:hasExactSynonym "paraxial mesoderm cell", "somitic mesoderm cell" ; oboInOwl:hasNarrowSynonym "presomitic mesoderm cell" ; a owl:Class ; rdfs:label "paraxial cell" ; rdfs:subClassOf obo:CL_0000222, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003059 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000222 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003059 ] ) ] . obo:CL_0011008 obo:IAO_0000115 "A hemocyte derived from the embryonic head mesoderm, which enters the hemolymph as a circulating cell." ; a owl:Class ; rdfs:label "embryonic hemocyte" ; rdfs:subClassOf obo:CL_0000387 . obo:CL_0011009 obo:IAO_0000115 "A plasmatocyte derived from the embryonic head mesoderm." ; a owl:Class ; rdfs:label "embryonic plasmatocyte" ; rdfs:subClassOf obo:CL_0000394, obo:CL_0011008 . obo:CL_0011010 obo:IAO_0000115 "A cell derived from the mesoderm that is found at the periphery of the embryo." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "lateral mesodermal cell" ; rdfs:subClassOf obo:CL_0000222 . obo:CL_0011011 obo:IAO_0000115 "A cell derived from the mesoderm that is located between the paraxial mesoderm and the lateral plate." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "intermediate mesodermal cell" ; rdfs:subClassOf obo:CL_0000222 . obo:CL_0011012 obo:IAO_0000115 "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." ; terms:description """Neural crest cells are a group of transient and highly migratory cells that originate from the neuroectoderm during the early stages of embryonic development. They are multipotent cells with an exceptional degree of plasticity, capable of differentiating into various somatic cell types and therefore play a fundamental role in the formation of various organs and tissues, making them critical contributors to the developing embryo. After the initiation of neurulation (the formation of the neural tube) neural crest cells start to undergo epithelial-to-mesenchymal transition and delaminate and migrate from the dorsal neural tube to several regions throughout the embryo. They differentiate into a range of diverse cell types, such as neurons and glial cells of the peripheral nervous system, including sensory and autonomic neurons. They also contribute to the formation of adrenal glands, pigment cells in the skin (melanocytes), cardiac structures, including parts of the heart septum and major arteries, as well as bones and cartilage of the face and skull. Disorders or aberrations in the development or migration of the neural crest cells can lead to serious congenital malformations, such as neurocristopathies, including Hirschsprung disease, neuroblastoma, and neurofibromatosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "neural crest cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0011012" ; rdfs:subClassOf obo:CL_0000048, obo:CL_0002321 ; skos:prefLabel "neural crest cell" . obo:CL_0011013 obo:IAO_0000115 "A sperm cell that is cabaple of motion (motility)." ; terms:contributor ; a owl:Class ; rdfs:label "motile sperm cell" ; rdfs:subClassOf obo:CL_0000019, obo:CL_0000219, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0097722 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000019 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0097722 ] ) ] . obo:CL_0011014 obo:IAO_0000115 "A sperm cell that is not cabaple of motion (motility)." ; terms:contributor ; a owl:Class ; rdfs:label "non-motile sperm cell" ; rdfs:subClassOf obo:CL_0000019 . obo:CL_0011015 obo:IAO_0000115 "A motile sperm cell that contain no F-actin, and their motility is powered by a dynamic filament system." ; terms:contributor ; a owl:Class ; rdfs:label "amoeboid sperm cell" ; rdfs:subClassOf obo:CL_0011013 . obo:CL_0011016 obo:IAO_0000115 "A motile sperm cell that contains a slender threadlike microscopic appendage that enables motion." ; terms:contributor ; a owl:Class ; rdfs:label "flagellated sperm cell" ; rdfs:subClassOf obo:CL_0011013, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030317 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011013 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030317 ] ) ] . obo:CL_0011017 obo:IAO_0000115 "Cell that is part of the vagal neural crest population. The vagal neural crest arises from the axial level of somites 1-7 and has been described as a hybrid between the head and the trunk populations." ; terms:contributor ; a owl:Class ; rdfs:label "vagal neural crest cell" ; rdfs:subClassOf obo:CL_0011012 . obo:CL_0011018 obo:IAO_0000115 "A group 3 innate lymphoid cell that express ROR gamma t and IL-7R alpha in the absence of lineage markers (e.g. CD3, CD19, B220, CD11c, Gr-1), with the functional ability to interact with mesenchymal cells through lymphotoxin and tumor necrosis factor. Lymphoid tissue-inducer cells are key to the development of lymph nodes and Peyer’s patches." ; terms:contributor ; oboInOwl:hasExactSynonym "LTi", "lymphoid tissue inducer cell" ; a owl:Class ; rdfs:label "lymphoid tissue–inducer cell" ; rdfs:subClassOf obo:CL_0001071, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ] . obo:CL_0011019 obo:IAO_0000115 "A mesothelial cell that is part of the epicardium." ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "mesothelial cell of epicardium" ; rdfs:subClassOf obo:CL_0000077, obo:CL_0002494, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002348 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002348 ] ) ] . obo:CL_0011020 obo:IAO_0000115 "An undifferentiated cell derived from a neural stem cell, with a limited capacity to self-renew (Dibajnia and Morshead, 2013) and the ability to generate multiple types of lineage-restricted progenitors, contributing to the formation of neurons, astrocytes, and oligodendrocytes." ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "neural progenitor cell" ; rdfs:subClassOf obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000047 ] . obo:CL_0011021 obo:IAO_0000115 "A fibroblast that is part of upper back skin." ; terms:contributor ; a owl:Class ; rdfs:label "fibroblast of upper back skin" ; rdfs:subClassOf obo:CL_0011022, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009015 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009015 ] ) ] . obo:CL_0011022 obo:IAO_0000115 "A fibroblast that is part of skin of back." ; terms:contributor ; a owl:Class ; rdfs:label "fibroblast of skin of back" ; rdfs:subClassOf obo:CL_0002620, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001068 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001068 ] ) ] . obo:CL_0011023 obo:IAO_0000115 "A mast cell that is CD25+." ; terms:contributor ; oboInOwl:hasExactSynonym "CD25+ neoplastic mast cell" ; a owl:Class ; rdfs:comment "Mast cells do not normally express CD25, but neoplastic mast cells may be CD25-positive." ; rdfs:label "CD25+ mast cell" ; rdfs:subClassOf obo:CL_0001063, [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:CL_0000097 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001063 [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:CL_0000097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] ) ] . obo:CL_0011024 obo:IAO_0000115 "A double negative thymocyte that is CD3-positive, CD4-negative, CD8-negative, that that are present in the periphery in very low numbers and predominantly produce INF-gamma, TNF-alpha, and a low amount of TGF-beta, but not IL-2, IL-4, IL-10 or IL-13 upon activation." ; terms:contributor ; oboInOwl:hasExactSynonym "CD4-negative, CD8-negative, alpha-beta regulatory T cells", "DN Treg", "double-negative alpha-beta regulatory T cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "double negative T regulatory cell" ; rdfs:subClassOf obo:CL_0002489, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002489 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] ) ] . obo:CL_0011025 obo:IAO_0000115 "An effector T cell that displays impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity) and has limited proliferative potential." ; terms:contributor ; oboInOwl:hasExactSynonym "Tex cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "exhausted T cell" ; rdfs:subClassOf obo:CL_0000911 . obo:CL_0011026 obo:IAO_0000115 "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "progenitor cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000255, obo:CL_0011115, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000034 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011115 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000034 ] ) ] ; skos:prefLabel "progenitor cell" . obo:CL_0011027 obo:IAO_0000115 "Any fibroblast that is part of skeletal muscle tissue." ; terms:contributor ; terms:description """Skeletal muscle fibroblasts (SMFs), with their spindle-shaped morphology, play a crucial role in maintaining the structure and function of skeletal muscles. They produce connective tissues enveloping muscle fibers, offering vital structural support for optimal muscle contraction. SMFs are integral components of the dynamic and complex microenvironment of muscle tissue, contributing significantly to healthy muscle development and homeostasis. SMFs primarily synthesize and secrete extracellular matrix (ECM) components, such as collagen, fibronectin, and proteoglycans. The resulting ECM exhibits mechanical properties that resist tensile forces from muscle contractions, ensuring muscle efficiency. It also crucially transmits force during muscle movement, aids muscle attachment to the skeletal structure, and serves as a scaffold for muscle regeneration and repair. Following injury, they proliferate and transform into myofibroblasts, aiding wound contraction and depositing new ECM for tissue repair. Additionally, these fibroblasts modulate inflammatory responses by secreting cytokines and interact with other cell types, like immune cells and satellite cells, to coordinate muscle healing. In diseases, an imbalance in SMF activity may lead to conditions such as fibrosis, marked by excessive ECM deposition and impaired muscle function. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasExactSynonym "skeleton muscle fibroblast" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "skeletal muscle fibroblast" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0011027" ; rdfs:subClassOf obo:CL_0000188, obo:CL_1001609 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001134 ] ) ] . obo:CL_0011028 obo:IAO_0000115 "A neural-crest derived glial cell that supports the growth and survival of primary olfactory neuroons from the neuroepithelium in the nasal cavity to the brain by encasing large bundles of numerous unmyelinated axons." ; terms:contributor ; oboInOwl:hasDbXref "BTO:0002771" ; oboInOwl:hasExactSynonym "OEC" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "olfactory ensheathing cell" ; rdfs:subClassOf obo:CL_0000125 . obo:CL_0011029 obo:IAO_0000115 "An explosive cell containing one giant secretory organelle called a cnidocyst (also known as a cnida (plural cnidae) or nematocyst) that contains a toxin responsible for the stings delivered by a cnidarian to other organisms. Cnidae are used to capture prey and as a defense against predators. The presence of cnidocytes defines the phylum Cnidaria (corals, sea anemones, hydrae, jellyfish, etc.)." ; terms:contributor ; oboInOwl:hasExactSynonym "cnidoblast", "nematocyte" ; a owl:Class ; rdfs:label "cnidocyte" ; rdfs:subClassOf obo:CL_0000151, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042151 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_6073 ] . obo:CL_0011030 obo:IAO_0000115 "Any microvascular endothelial cell that is part of the dermis." ; terms:contributor ; oboInOwl:hasExactSynonym "DMEC cell", "dermal microvascular endothelium cell" ; a owl:Class ; rdfs:label "dermal microvascular endothelial cell" ; rdfs:subClassOf obo:CL_2000008, obo:CL_2000010 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] ) ] . obo:CL_0011031 obo:IAO_0000115 "A dendritic cell that develops from a monocyte." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasExactSynonym "MDDC cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "monocyte-derived dendritic cell" ; rdfs:subClassOf obo:CL_0000782, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000576 ] . obo:CL_0011032 obo:IAO_0000115 "An enterocyte that possesses a large supranuclear vacuolar system that preferentially internalizes dietary protein via receptor-mediated and fluid-phase endocytosis for intracellular digestion and trans-cellular transport. In zebrafish these cells are located in the posterior region of the mid intestine throughout life. In mammals they are found in the ileum pre-weaning and later are replaced by mature enterocytes." ; terms:contributor ; oboInOwl:hasBroadSynonym "vacuolated enterocyte" ; oboInOwl:hasExactSynonym "LRE" ; oboInOwl:hasRelatedSynonym "early enterocyte", "immature enterocyte" ; a owl:Class ; rdfs:label "lysosome-rich enterocyte" ; rdfs:subClassOf obo:CL_0000584 . obo:CL_0011100 obo:IAO_0000115 "Neuron that secretes the neurotransmitter galanin." ; a owl:Class ; rdfs:label "galanergic neuron" ; rdfs:subClassOf obo:CL_0000540 . obo:CL_0011101 obo:IAO_0000115 "Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." ; terms:description """The chorionic trophoblast cell, vital for placental development in mammals, originates from the blastocyst's outer layer, the trophectoderm. As a significant component of the placenta, the chorion forms the external fetal-maternal interface and consists primarily of chorionic trophoblast cells. These cells are pivotal in embryogenesis, fetal nutrition, waste removal, and immune response generation, contributing crucially to the success of pregnancy. Chorionic trophoblast cells undergo trophoblast differentiation, giving rise to specialized sub-types: cytotrophoblasts and syncytiotrophoblasts. Cytotrophoblasts, found in the inner layer, serve as stem cells and contribute to proliferative activities. In contrast, syncytiotrophoblasts, originating from cytotrophoblasts, form the outer layer with a distinctive multinucleated, continuous, and non-proliferative structure. These cells play a key role in maternal-fetal gas and nutrient exchange, producing essential hormones like human chorionic gonadotropin (hCG), progesterone, and estrogen, vital for sustaining pregnancy. Apart from their physiological roles, chorionic trophoblast cells play a crucial role in shielding the fetus from the maternal immune system. They accomplish this by modifying the expression of major histocompatibility complex (MHC) molecules, which are self-identifying proteins utilized by the immune system to identify foreign cells. Through selective expression of specific types of these molecules, trophoblast cells can evade cytotoxic T cells that might otherwise attack them, while still retaining the ability to attract natural killer cells. These natural killer cells assist in trophoblast invasion and the remodeling of blood vessels in the uterus. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "chorionic trophoblast cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0011101" ; rdfs:subClassOf obo:CL_0000351, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003124 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000351 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003124 ] ) ] . obo:CL_0011102 obo:IAO_0000115 "Parasympathetic neurons are part of the parasympathetic nervous sysem and the cell bodies lie in the brain and sacral region of the spinal cord. The neurons are mainly cholinergic." ; oboInOwl:hasDbXref "ZFA:0005776" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "parasympathetic neuron" ; rdfs:subClassOf obo:CL_0000107 . obo:CL_0011103 obo:IAO_0000115 "Sympathetic neurons are part of the sympathetic nervous system and are primarily adrenergic producing the neurotransmitter noradrenalin along with other neuropeptides." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "ZFA:0005777" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "sympathetic neuron" ; rdfs:subClassOf obo:CL_0000107 . obo:CL_0011104 obo:IAO_0000115 """A type of interneuron in the retinal inner nuclear layer which carries information from the inner plexiform layer and the outer plexiform layer.""" ; oboInOwl:inSubset cl:eye_upper_slim ; a owl:Class ; rdfs:comment "Need to MIREOT retinal inner nuclear layer (part of)" ; rdfs:label "interplexiform cell" ; rdfs:subClassOf obo:CL_0000099, obo:CL_0000748, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001791 ] . obo:CL_0011105 obo:IAO_0000115 """A type of interneuron in the retinal inner nuclear layer which carries information from the inner plexiform layer and the outer plexiform layer, using dopamine.""" ; a owl:Class ; rdfs:comment "This type of cell is found in Danio rerio." ; rdfs:label "dopamanergic interplexiform cell" ; rdfs:subClassOf obo:CL_0000700, obo:CL_0011104 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011104 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061527 ] ) ] . obo:CL_0011106 obo:IAO_0000115 """A type of interneuron in the retinal inner nuclear layer which carries information from the inner plexiform layer and the outer plexiform layer using GABA.""" ; a owl:Class ; rdfs:comment "This type of cell is found in many mammals." ; rdfs:label "GABAnergic interplexiform cell" ; rdfs:subClassOf obo:CL_0008060, obo:CL_0011005, obo:CL_0011104 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011104 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ) ] . obo:CL_0011107 obo:IAO_0000115 "OBSOLETE: Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer." ; obo:IAO_0100001 obo:CL_0000636 ; oboInOwl:hasExactSynonym "Muller glia", "Müller cell" ; a owl:Class ; rdfs:comment "Term was duplicated, use CL:0000636 instead" ; rdfs:label "obsolete Muller cell" ; owl:deprecated true . obo:CL_0011108 obo:IAO_0000115 "Epithelial cell that is part of the colon epithelium." ; oboInOwl:hasExactSynonym "colonic epithelial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "colon epithelial cell" ; rdfs:subClassOf obo:CL_0002253, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000397 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000397 ] ) ] . obo:CL_0011109 obo:IAO_0000115 "A neuron that releases hypocretin as a neurotransmitter." ; oboInOwl:hasDbXref "ZFA:0005778" ; oboInOwl:hasExactSynonym "orexin" ; a owl:Class ; rdfs:label "hypocretin-secreting neuron" ; rdfs:subClassOf obo:CL_0000151, obo:CL_0000540, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061585 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061585 ] ) ] . obo:CL_0011110 obo:IAO_0000115 "Neuron that secretes histamine." ; oboInOwl:hasDbXref "FBbt:00007367" ; a owl:Class ; rdfs:label "histaminergic neuron" ; rdfs:subClassOf obo:CL_0000540, obo:CL_0002274, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061538 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061538 ] ) ] . obo:CL_0011111 obo:IAO_0000115 "a specialized neuroendocrine cell that synthesizes and secretes GnRH decapeptide, a key regulator of reproductive function. It originates from the olfactory placode during embryonic development and migrates into the forebrain where it localises predominantly in the hypothalamus and in humans, in extrahypothalamic regions like the basal ganglia (Skrapits et al., 2021). This cell regulates reproduction by secreting GnRH into the pituitary portal vessels to induce the release of gonadotropins into the general circulation. It expresses receptor subunits required for AMPA, NMDA, and kainate receptor signaling and may use glutamate as a neurotransmitter in recurrent collateral innervation." ; oboInOwl:hasExactSynonym "GnRH neuron", "GnRH-secreting neuron" ; a owl:Class ; rdfs:label "hypothalamic gonadotropin-releasing hormone neuron" ; rdfs:subClassOf obo:CL_0000165, obo:CL_0012001, [ a owl:Restriction ; owl:onProperty obo:RO_0002596 ; owl:someValuesFrom obo:GO_0032274 ] . obo:CL_0011112 obo:IAO_0000115 "OBSOLETE: Neurons part of the hypothalamic supraoptic and paraventricular nuclei that secrete the hormones, oxytocin and vasopressin into the systemic circulation from the posterior pituitary gland." ; obo:IAO_0100001 obo:CL_0011003 ; a owl:Class ; rdfs:comment "Duplicated term, please see CL:0011003 instead" ; rdfs:label "obsolete magnocellular neurosecretory cell" ; owl:deprecated true . obo:CL_0011113 obo:IAO_0000115 "Neuron found in the spiral ganglion." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "spiral ganglion neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000032, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000395 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000032 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000395 ] ) ] . obo:CL_0011114 obo:IAO_0000115 "A segmented neutrophilic cell of the bone marrow reserve pool that expresses CD11b (integrin alpha-M) and high levels of CD16 (low affinity immunoglobulin gamma Fc region receptor III) on its cell surface." ; a owl:Class ; rdfs:label "segmented neutrophil of bone marrow" ; rdfs:subClassOf obo:CL_0000096, obo:CL_1001610 . obo:CL_0011115 obo:IAO_0000115 "A cell that, by division or terminal differentiation, can give rise to other cell types." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell." ; rdfs:label "precursor cell" ; rdfs:subClassOf obo:CL_0000000, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030154 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030154 ] ) ] ; skos:prefLabel "precursor cell" . obo:CL_0012000 obo:IAO_0000115 "An astrocyte of the forebrain." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasExactSynonym "forebrain astrocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "astrocyte of the forebrain" ; rdfs:subClassOf obo:CL_0000127, obo:CL_2000005, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000127 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ] ) ] . obo:CL_0012001 obo:IAO_0000115 "A CNS neuron of the forebrain." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasExactSynonym "forebrain neuron" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "neuron of the forebrain" ; rdfs:subClassOf obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001890 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001890 ] ) ] ; skos:prefLabel "neuron of the forebrain" . obo:CL_0013000 obo:IAO_0000115 "Any radial glial cell that is part of some forebrain." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "forebrain radial glial cell"@en ; rdfs:subClassOf obo:CL_0000681, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000681 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ] ) ] . obo:CL_0015000 obo:IAO_0000115 "Motor neuron that innervate muscles that control eye, jaw, and facial movements of the vertebrate head and parasympathetic neurons that innervate certain glands and organs." ; oboInOwl:hasDbXref "PMID:14699587", "ZFA:0005730" ; oboInOwl:hasExactSynonym "cranial motoneuron" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cranial motor neuron" ; rdfs:subClassOf obo:CL_0000100 . obo:CL_0017000 obo:IAO_0000115 "An ionocyte that is part of the lung epithelium. The cells from this type are major sources of the CFTR protein in human and mice." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description """The pulmonary ionocyte is a relatively newly identified, specific epithelial cell type found primarily in the pulmonary or respiratory system. Discovered through novel mapping techniques in 2018, these cells are surprisingly rare, making up less than 2% of the cells in the lung's airway, yet they play an essential role in the airway surface liquid and mucus regulation, a crucial factor in lung health. The main responsibility of the pulmonary ionocyte pertains to the regulation and mobilization of chloride ions. They express a high level of CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene, which encodes a protein channel across the membrane of cells that produce mucus, sweat, saliva, tears, and digestive enzymes. The activity of CFTR regulates the movement of chloride ions and fluids in and out of cells, which helps maintain a balance of fluid in the organs they are expressed in. If CFTR is dysfunctional, it can cause conditions such as cystic fibrosis, characterized by thick, sticky mucus that can clog the lungs and obstruct the pancreas, leading to respiratory and digestive issues. The discovery of this cell type offers new doors to the treatment and further understanding of diseases like cystic fibrosis. Increased understanding of pulmonary ionocytes could contribute to the development of novel therapeutic approaches to manipulate the function of CFTR in the lungs and other organs affected by dysfunctional CFTR. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The marker set ASCL3, BSND can identify the Human cell type pulmonary ionocyte in the lung with a confidence of 0.82 (NS-Forest FBeta value)." ; rdfs:label "pulmonary ionocyte" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0017000" ; rdfs:subClassOf obo:CL_0000082, obo:CL_0005006, [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000032 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005006 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000115 ] ) ] . obo:CL_0017001 obo:IAO_0000115 "A mesodermal cell that is part of the splanchnic layer of lateral plate mesoderm." ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "splanchnic mesodermal cell" ; rdfs:subClassOf obo:CL_0011010, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004872 ] . obo:CL_0017002 obo:IAO_0000115 "A neuroendocrine cell that is part of the prostate epithelium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasExactSynonym "neuroendocrine cell of prostate epithelium", "neuroendocrine cell of the prostate" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "prostate neuroendocrine cell" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000165, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000428 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000165 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000428 ] ) ] . obo:CL_0017003 obo:IAO_0000115 "An epithelial cell that is part of the prostatic urethra." ; terms:contributor ; a owl:Class ; rdfs:label "epithelial cell of prostatic urethra" ; rdfs:subClassOf obo:CL_1000296, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001335 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001335 ] ) ] . obo:CL_0017004 obo:IAO_0000115 "A supportive cell with a small, oval-shaped body and one to five telopodes. Telopodes are cytoplasmic protrusions from tens to hundreds of micrometers long and mostly below 0.2 microns of caliber." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasNarrowSynonym "interstitial Cajal cell-like cell", "interstitial Cajal-like cell" ; oboInOwl:hasRelatedSynonym "ICLC", "interstitial neuron" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Telocytes manage to develop complex networks in almost all organs of the human body. Although staining positively for vimentin antibody, some uncertainty still persists over the mesenchymal origin of these cells." ; rdfs:label "telocyte" ; rdfs:subClassOf obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0120327 ] . obo:CL_0017005 obo:IAO_0000115 "A lymphocyte that has gotten larger after being stimulated by an antigen." ; terms:contributor ; terms:date "2022-08-17T14:20:01Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0000772", "EFO:0000572", "FMA:83030" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:label "lymphoblast" ; rdfs:subClassOf obo:CL_0000542, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0046649 ] . obo:CL_0017006 obo:IAO_0000115 "A lymphocyte of B lineage that has gotten larger after being stimulated by an antigen." ; terms:contributor ; terms:date "2022-08-17T14:30:32Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0005293", "FMA:83031" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:label "B-lymphoblast" ; rdfs:subClassOf obo:CL_0000945, obo:CL_0017005 . obo:CL_0017009 obo:IAO_0000115 "A human dendritic cell that expresses the AXL and SIGLEC6 genes." ; terms:contributor ; terms:date "2022-08-25T14:18:37Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "AS DC, human" ; a owl:Class ; rdfs:label "Axl+ dendritic cell, human" ; rdfs:subClassOf obo:CL_0001056, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_O43699 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_P30530 ] . obo:CL_0017010 obo:IAO_0000115 "A hillock cell that is part of the urethra." ; terms:contributor ; terms:date "2022-10-13T13:51:35Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "hillock cell of urethra" ; a owl:Class ; rdfs:label "hillock cell of urethral epithelium" ; rdfs:subClassOf obo:CL_1000296, obo:CL_4030024 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4030024 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:CL_0017011 obo:IAO_0000115 "A hillock cell that is part of the prostatic urethra." ; terms:contributor ; terms:date "2022-10-13T13:58:15Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "hillock cell of prostatic urethra" ; a owl:Class ; rdfs:label "hillock cell of prostatic urethral epithelium" ; rdfs:subClassOf obo:CL_0017003, obo:CL_0017010 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4030024 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001335 ] ) ] . obo:CL_0017500 obo:IAO_0000115 "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain." ; terms:contributor ; oboInOwl:creation_date "2010-05-25T01:36:34Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "neutrophillic cytoplasm" ; rdfs:subClassOf obo:GO_0005737, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070046 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005737 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070046 ] ) ] . obo:CL_0017501 obo:IAO_0000115 "Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin." ; obo:IAO_0000233 ; obo:IAO_0100001 obo:GO_0098537 ; terms:contributor ; oboInOwl:creation_date "2009-12-22T03:54:43Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Obsoleted because duplicate with GO term." ; rdfs:label "obsolete lobed nucleus" ; owl:deprecated true . obo:CL_0017502 obo:IAO_0000115 "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain." ; terms:contributor ; oboInOwl:creation_date "2009-12-22T04:23:25Z"^^xsd:dateTime ; oboInOwl:hasNarrowSynonym "eosinophilic" ; a owl:Class ; rdfs:label "acidophilic cytoplasm" ; rdfs:subClassOf obo:GO_0005737, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002418 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005737 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002418 ] ) ] ; skos:prefLabel "acidophilic cytoplasm" . obo:CL_0017503 obo:IAO_0000115 "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." ; terms:contributor ; oboInOwl:creation_date "2009-12-22T04:24:54Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "basophilic cytoplasm" ; rdfs:subClassOf obo:GO_0005737, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002094 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005737 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002094 ] ) ] ; skos:prefLabel "basophilic cytoplasm" . obo:CL_0017504 obo:IAO_0000115 "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." ; terms:contributor ; oboInOwl:creation_date "2009-12-28T04:25:23Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "polychromatophilic cytoplasm" ; rdfs:subClassOf obo:GO_0005737, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070047 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005737 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070047 ] ) ] ; skos:prefLabel "polychromatophilic cytoplasm" . obo:CL_0017505 obo:IAO_0000115 "OBSOLETE. A nucleus size quality which is relatively high compared to the amount of cytoplasm present in the same cell." ; obo:IAO_0000233 ; obo:IAO_0100001 obo:PATO_0040072 ; terms:contributor ; oboInOwl:creation_date "2009-12-23T10:53:24Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "This class was a phenotype, not a cell type." ; rdfs:label "obsolete increased nucleus size" ; owl:deprecated true . obo:CL_0017506 obo:IAO_0000115 "A concave nuclear shape where the nucleus is indented to more than half the distance to the farthest nuclear margin, but in no area is the chromatin condensed to a single filament." ; terms:contributor ; oboInOwl:creation_date "2009-12-23T02:18:43Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "banded nucleus" ; rdfs:subClassOf obo:GO_0005634 . obo:CL_0017507 obo:IAO_0000115 "A concave nucleus shape where the indentation is smaller than half of the distance to the farthest nuclear margin." ; terms:contributor ; oboInOwl:creation_date "2009-12-23T02:31:25Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "reniform nucleus" ; rdfs:subClassOf obo:GO_0005634, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001871 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005634 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001871 ] ) ] . obo:CL_0017508 obo:IAO_0000115 "Heterochromatin that is arranged in a carthwheel pattern." ; terms:contributor ; oboInOwl:creation_date "2009-12-28T04:28:35Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "cartwheel heterochromatin" ; rdfs:subClassOf obo:GO_0000792 . obo:CL_0017509 obo:IAO_0000115 "Any nucleus that has characteristic some alobate." ; a owl:Class ; rdfs:label "alobate nucleus"@en ; rdfs:subClassOf obo:GO_0005634, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002506 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005634 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002506 ] ) ] . obo:CL_0019001 obo:IAO_0000115 "Any serous secreting cell that is part of the tracheobronchial epithelium." ; terms:contributor ; terms:date "2020-05-07T16:03:27Z"^^xsd:dateTime ; terms:description """Serous cells of the tracheobronchial are found on the surface epithelium, submucosal glands, or both, depending on species. They appear in tubulo-acinar arrangements in submucosal glands. Tracheobronchial serous cells play a vital role in maintaining respiratory health by secreting serous fluid, which is rich in enzymes, ions, and antimicrobial proteins. This serous fluid is essential in clearing out debris, trapping and neutralizing inhaled pathogens and particulate matters, thereby helping in preventing infections. Their secretory products also include water and electrolytes that, combined with mucus (from mucous cells), maintain proper humidity within the airway and lubricate its surfaces, facilitating unhindered airflow. Dysfunction of these cells may lead to diseases such as cystic fibrosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasExactSynonym "serous cell of tracheobronchial tree" ; oboInOwl:inSubset cl:added_for_HCA, cl:cellxgene_subset ; a owl:Class ; rdfs:label "tracheobronchial serous cell"@en ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0019001" ; rdfs:subClassOf obo:CL_0000255, obo:CL_0000313, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007196 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000313 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007196 ] ) ] . obo:CL_0019002 obo:IAO_0000115 "Any chondrocyte that is part of the tracheobronchial tree." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2020-05-07T17:29:51Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "chondrocyte of tracheobronchial tree" ; oboInOwl:inSubset cl:added_for_HCA, core:human_reference_atlas ; a owl:Class ; rdfs:label "tracheobronchial chondrocyte"@en ; rdfs:subClassOf obo:CL_0000138, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007196 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000138 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007196 ] ) ] . obo:CL_0019003 obo:IAO_0000115 "Any goblet cell that is part of the tracheobronchial epithelium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2020-05-07T18:14:52Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "goblet cell of tracheobronchial tree" ; oboInOwl:inSubset cl:added_for_HCA, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "tracheobronchial goblet cell"@en ; rdfs:subClassOf obo:CL_0002202, obo:CL_0002370 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008397 ] ) ] . obo:CL_0019015 obo:IAO_0000115 "An eosinophil with a ring-shaped nucleus that is resident in the lung parenchyma. In mouse, lung parenchyma resident eosinophils are IL-5-independent Siglec-F(intermediate) CD62L+ CD101(low). In human, they are Siglec-8+ CD62L+ IL-3R(low)." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2020-05-26T09:42:19Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "lung-resident eosinophil", "rEos" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lung parenchyma resident eosinophil"@en ; rdfs:subClassOf obo:CL_0000774, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008946 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000774 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008946 ] ) ] . obo:CL_0019017 obo:IAO_0000115 "A smooth muscle cell that is part of any lymphatic vessel." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2020-07-21T12:29:51Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "smooth muscle cell of lymphatic vessel" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lymphatic vessel smooth muscle cell"@en ; rdfs:subClassOf obo:CL_0000359, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001473 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001473 ] ) ] . obo:CL_0019018 obo:IAO_0000115 "A smooth muscle cell that is part of any blood vessel." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2020-07-21T12:42:48Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "smooth muscle cell of blood vessel" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "blood vessel smooth muscle cell"@en ; rdfs:subClassOf obo:CL_0000359, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ] ) ] . obo:CL_0019019 obo:IAO_0000115 "A smooth muscle cell that is part of the tracheobronchial tree." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2020-07-21T12:50:22Z"^^xsd:dateTime ; terms:description """Tracheobronchial smooth muscle cells are universally located in the tracheobronchial tree and play a critical role in controlling and modulating the size of the airway lumen, thereby contributing significantly to the airflow resistance. These cells display both phasic and tonic characteristics, which are vital for airway contractility. Phasic activity manifests as cyclic contraction and relaxation, similar to the behavior seen in gastrointestinal smooth muscle cells, whilst tonic activity resembles vascular smooth muscle cells, maintaining a constant degree of tension. These features enable tracheobronchial smooth muscle cells to constrict the airways in response to various mechanical and chemical stimuli, including allergens, parasympathetic nervous stimulation, changes in gas composition, and cold air, thus protecting the delicate alveoli from potential damage. Tracheobronchial smooth muscle cells, beyond their contractile function, actively contribute to airway remodeling in conditions like asthma. Their proliferative and synthetic capabilities lead to smooth muscle hypertrophy, hyperplasia, and the production of extracellular matrix components, collectively causing abnormal airway narrowing. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasExactSynonym "smooth muscle cell of tracheobronchial tree" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The marker set ACTA2, TAGLN can identify the Human cell type tracheobronchial smooth muscle cell in the lung with a confidence of 0.69 (NS-Forest FBeta value)." ; rdfs:label "tracheobronchial smooth muscle cell"@en ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0019019" ; rdfs:subClassOf obo:CL_0000192, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007196 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000056 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007196 ] ) ] . obo:CL_0019020 obo:IAO_0000115 "An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes." ; terms:contributor ; terms:date "2020-09-03T12:24:24Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "large bile duct cholangiocyte" ; a owl:Class ; rdfs:label "extrahepatic cholangiocyte"@en ; rdfs:subClassOf obo:CL_1000488, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004822 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000488 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004822 ] ) ] . obo:CL_0019021 obo:IAO_0000115 "An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid." ; terms:contributor ; terms:date "2020-09-09T13:56:47Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0010705" ; oboInOwl:hasExactSynonym "periportal LSEC", "periportal hepatic sinusoidal endothelial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "endothelial cell of periportal hepatic sinusoid"@en ; rdfs:subClassOf obo:CL_1000398, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001279 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000398 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001279 ] ) ] . obo:CL_0019022 obo:IAO_0000115 "An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid." ; terms:contributor ; terms:date "2020-09-10T12:38:29Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0010706" ; oboInOwl:hasExactSynonym "central venous hepatic sinusoidal endothelial cell", "pericentral LSEC" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "endothelial cell of pericentral hepatic sinusoid"@en ; rdfs:subClassOf obo:CL_1000398, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0006841 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000398 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0006841 ] ) ] . obo:CL_0019026 obo:IAO_0000115 "Any hepatocyte that is part of the liver lobule periportal region. These cells are primarily involved in oxidative energy metabolism." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2020-10-12T10:29:31Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "periportal hepatocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "periportal region hepatocyte"@en ; rdfs:subClassOf obo:CL_0000182, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8400006 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000182 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8400006 ] ) ] . obo:CL_0019028 obo:IAO_0000115 "Any hepatocyte that is part of the liver lobule midzonal region. These cells have mixed functionality in comparison with those in the other two regions of the liver lobule." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2020-10-12T10:57:40Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "midzonal hepatocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "midzonal region hepatocyte"@en ; rdfs:subClassOf obo:CL_0000182, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8400007 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000182 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8400007 ] ) ] . obo:CL_0019029 obo:IAO_0000115 "Any hepatocyte that is part of the liver lobule centrilobular region. These cells are the primary location for the biotransformation of drugs." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2020-10-12T11:03:51Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "centrilobular hepatocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "centrilobular region hepatocyte"@en ; rdfs:subClassOf obo:CL_0000182, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8400008 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000182 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8400008 ] ) ] . obo:CL_0019031 obo:IAO_0000115 "Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3." ; terms:contributor ; terms:date "2020-10-14T14:59:07Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "intestinal goblet cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "intestine goblet cell"@en ; rdfs:subClassOf obo:CL_0000160, obo:CL_0002563, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_4047017 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001277 ] ) ] . obo:CL_0019032 obo:IAO_0000115 "A tuft cell that is part of the intestinal epithelium, characterized by a distinctive apical tuft and lateral cytospinules connecting to neighbouring cells. This cell senses luminal stimuli via taste receptors and succinate signalling, initiating type 2 immune responses through the secretion of interleukin-25 while modulating epithelial regeneration through prostaglandin synthesis. It expresses key molecular markers such as doublecortin-like kinase 1 (DCLK1) in mice (Hendel et al., 2022), and KIT proto-oncogene in humans (Huang et al., 2024). Developed from intestinal crypt stem cells, this cell requires transcription factor POU2F3 for its development." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2020-10-15T12:47:46Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "intestinal brush cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "intestinal tuft cell"@en ; rdfs:subClassOf obo:CL_0002204, obo:CL_0002563, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002250 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001277 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/large-intestine-crypt-lieberkuhn/v1.2/assets/2d-ftu-large-intestine-crypt-lieberkuhn.png" . obo:CL_0700009 obo:IAO_0000115 "OBSOLETE. A renal beta-intercalated cell that is part of the cortical collecting duct. The medullary collecting duct does not contain the renal beta-intercalated cell type." ; obo:IAO_0100001 obo:CL_4030005 ; terms:date "2022-08-26T10:31:29Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "B-IC", "kidney collecting duct intercalated cell type B" ; a owl:Class ; rdfs:comment "Created with IRI in incorrect ID range" ; rdfs:label "obsolete kidney collecting duct beta-intercalated cell" ; owl:deprecated true . obo:CL_1000001 obo:IAO_0000115 "Any neuron that has its soma located in some retrotrapezoid nucleus." ; a owl:Class ; rdfs:label "retrotrapezoid nucleus neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0009918 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0009918 ] ) ] . obo:CL_1000022 obo:IAO_0000115 "Any epithelial cell that is part of some mesonephric nephron tubule." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "mesonephric nephron tubule epithelial cell" ; rdfs:subClassOf obo:CL_1000449, obo:CL_1000507, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005329 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005329 ] ) ] . obo:CL_1000036 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002196 ; a owl:Class ; owl:deprecated true . obo:CL_1000042 obo:IAO_0000115 "Any neuroblast (sensu Vertebrata) that is part of some forebrain." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "forebrain neuroblast" ; rdfs:subClassOf obo:CL_0000031, obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000031 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ] ) ] . obo:CL_1000050 obo:IAO_0000115 "Any glial cell that is part of some lateral line nerve." ; a owl:Class ; rdfs:label "lateral line nerve glial cell" ; rdfs:subClassOf obo:CL_0000125, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008906 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008906 ] ) ] . obo:CL_1000073 obo:IAO_0000115 "Any radial glial cell that is part of some spinal cord." ; a owl:Class ; rdfs:label "spinal cord radial glial cell" ; rdfs:subClassOf obo:CL_0000681, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000681 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:CL_1000082 oboInOwl:hasDbXref "ZFA:0009370" ; a owl:Class ; rdfs:label "stretch receptor cell" ; rdfs:subClassOf obo:CL_0000006 . obo:CL_1000083 oboInOwl:hasDbXref "ZFA:0009371" ; a owl:Class ; rdfs:label "stratified keratinized epithelial stem cell" ; rdfs:subClassOf obo:CL_0000357 . obo:CL_1000085 a owl:Class ; rdfs:label "stratified non keratinized epithelial stem cell" ; rdfs:subClassOf obo:CL_0000357 . obo:CL_1000090 obo:IAO_0000115 "Any epithelial cell that is part of some pronephric nephron tubule." ; a owl:Class ; rdfs:label "pronephric nephron tubule epithelial cell" ; rdfs:subClassOf obo:CL_1000449, obo:CL_1000507, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005310 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005310 ] ) ] . obo:CL_1000123 obo:IAO_0000115 "Any epithelial cell that is part of some metanephric nephron tubule." ; a owl:Class ; rdfs:label "metanephric nephron tubule epithelial cell" ; rdfs:subClassOf obo:CL_1000449, obo:CL_1000507, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005146 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005146 ] ) ] . obo:CL_1000143 obo:IAO_0000115 "Any goblet cell that is part of some lung epithelium." ; terms:description """Lung goblet cells are critical components of the respiratory tract, specifically found in the bronchial segments. They are secretory epithelial cells known for their signature \"goblet\" or cup-like shape. Their primary function is to produce and secrete mucus that aids in trapping airborne particles and pathogens, preventing them from reaching the delicate environment of the lung. As part of the lung's epithelial lining, they act as frontline defenders, maintaining lung health and function. The lung goblet cells are densely packed with granules containing mucin glycoproteins, the primary component of mucus. As mucus is produced and secreted, it moves towards the lumen of the lungs where the cilia, hair-like structures of the neighboring ciliated epithelial cells, help to navigate it upwards and out of the respiratory tract. This coordinated action ensures the expulsion of unwanted particles and pathogens, effectively cleaning the respiratory tract. Dysfunction or abnormal proliferation of lung goblet cells can result in pathological conditions such as chronic obstructive pulmonary disorder (COPD) and asthma, where excessive mucus production leads to airway obstruction. Furthermore, lung goblet cells respond to a variety of stimuli, including toxins, allergens, irritants, and infections, adjusting their mucus production accordingly. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "lung goblet cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000143" ; rdfs:subClassOf obo:CL_0000082, obo:CL_0002370, obo:CL_1000272 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000115 ] ) ] . obo:CL_1000147 obo:IAO_0000115 "A cell that is part of a cardiac valve." ; oboInOwl:hasDbXref "ZFA:0009402" ; oboInOwl:hasExactSynonym "heart valve cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cardiac valve cell" ; rdfs:subClassOf obo:CL_0002494, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000946 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000946 ] ) ] . obo:CL_1000155 obo:IAO_0000115 "A specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium." ; oboInOwl:hasDbXref "FBbt:00005797" ; oboInOwl:hasExactSynonym "Malpighian tubule Type II cell" ; a owl:Class ; rdfs:label "Malpighian tubule stellate cell" ; rdfs:subClassOf obo:CL_0000151, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001054 ] . obo:CL_1000182 obo:IAO_0000115 "Any tip cell that is part of some Malpighian tubule." ; a owl:Class ; rdfs:label "malpighian tubule tip cell" ; rdfs:subClassOf obo:CL_0000255, obo:CL_0000423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001054 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000423 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001054 ] ) ] . obo:CL_1000191 obo:IAO_0000115 "A rod-like cell in the inner ear, having their heads joined and their bases on the basilar membrane widely separated so as to form a spiral tunnel known as the tunnel of Corti." ; oboInOwl:hasDbXref "FMA:75722" ; oboInOwl:hasExactSynonym "pillar cell of cochlea", "pillar cell of corti", "rod cell of Corti" ; oboInOwl:hasRelatedSynonym "cochlear pillar cell" ; a owl:Class ; rdfs:label "pillar cell" ; rdfs:subClassOf obo:CL_0002490 . obo:CL_1000217 obo:IAO_0000115 "Any chondrocyte that is part of some growth plate cartilage." ; a owl:Class ; rdfs:label "growth plate cartilage chondrocyte" ; rdfs:subClassOf obo:CL_0000138, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004129 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000138 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004129 ] ) ] . obo:CL_1000222 obo:IAO_0000115 "A specialised neuroendocrine cell located in the gastric mucosa that regulates digestive processes including acid secretion and gut motility. This cell stores hormones in large dense core vesicles and synaptic-like microvesicles." ; oboInOwl:hasBroadSynonym "DES cell", "diffuse endocrine system cell" ; a owl:Class ; rdfs:label "stomach neuroendocrine cell" ; rdfs:subClassOf obo:CL_0000165, obo:CL_1001517, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0046717 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000165 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001276 ] ) ] . obo:CL_1000223 obo:IAO_0000115 "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Pulmonary neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Pulmonary neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Lung neuroendocrine cells, also commonly known as pulmonary neuroendocrine cells (PNECs), are predominantly located in the respiratory epithelium of the bronchial and bronchiolar airways in the lungs. These cells, characterised by their small size and granular appearance, have a distinctive morphology that sets them apart from other lung cells. They are considered part of the diffuse neuroendocrine system due to their scattered distribution through the epithelium and have been classified into solitary cells and clustered forms known as neuroepithelial bodies. The primary function of PNECs is linked to regulation and maintenance of the lung environment. They are sensory in nature and can secrete various bioactive substances such as serotonin, calcitonin, calcitonin gene-related peptides, and bombesin-like peptides which modulate airway smooth muscle tone and influence gut motility. For example, they act as oxygen sensors in response to hypoxia and are responsible for releasing neuropeptides that can induce responses. Moreover, PNECs provide an afferent function as they are equipped with long microvilli that project into the lumen of the bronchus and react to changes in the chemical composition of the luminal content. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasExactSynonym "lung neuroendocrine cell" ; oboInOwl:hasRelatedSynonym "PNEC" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The marker set CHGA, GRP can identify the Human cell type pulmonary neuroendocrine cell in the lung with a confidence of 0.94 (NS-Forest FBeta value)." ; rdfs:label "pulmonary neuroendocrine cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000223" ; rdfs:subClassOf obo:CL_0000006, obo:CL_0000098, obo:CL_0000165, obo:CL_0000206, obo:CL_0000458, obo:CL_1000272, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0031045 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070483 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000043 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000165 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:CL_1000236 obo:IAO_0000115 "Any glial cell that is part of some posterior lateral line nerve." ; a owl:Class ; rdfs:label "posterior lateral line nerve glial cell" ; rdfs:subClassOf obo:CL_1000050, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_2000175 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_2000175 ] ) ] . obo:CL_1000239 obo:IAO_0000115 "Any glial cell that is part of some anterior lateral line nerve." ; a owl:Class ; rdfs:label "anterior lateral line nerve glial cell" ; rdfs:subClassOf obo:CL_1000050, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_2000425 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_2000425 ] ) ] . obo:CL_1000245 obo:IAO_0000115 "Any peripheral nervous system neuron that has its soma located in some posterior lateral line ganglion." ; a owl:Class ; rdfs:label "posterior lateral line ganglion neuron" ; rdfs:subClassOf obo:CL_2000031, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_2001314 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000032 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_2001314 ] ) ] . obo:CL_1000271 obo:IAO_0000115 "An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "lung ciliated cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "lung multiciliated epithelial cell" ; rdfs:subClassOf obo:CL_0000082, obo:CL_4030034 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000115 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0031514 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0010007 ] ) ] . obo:CL_1000272 obo:IAO_0000115 "Any secretory cell that is part of some lung." ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "lung secretory cell" ; rdfs:subClassOf obo:CL_0000151, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:CL_1000274 obo:IAO_0000115 "An extraembryonic cell that is part of the trophectoderm, representing the first lineage to differentiate in the embryo. This cell is crucial for implantation into the uterine wall and differentiates into trophoblast cells, which contribute to placenta formation and facilitate maternal-fetal nutrient and signal exchange." ; oboInOwl:hasExactSynonym "trophectoderm cell" ; a owl:Class ; rdfs:label "trophectodermal cell" ; rdfs:subClassOf obo:CL_0000349, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004345 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000351 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000349 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004345 ] ) ] . obo:CL_1000275 obo:IAO_0000115 "A smooth muscle cell that is part of the small intestine." ; terms:description """Smooth muscle cells of the small intestine form a key component of the enteric system which is imperative for gastrointestinal motility. These cells are a specialized subgroup of smooth muscle cells, specifically found in the layers of the small intestine. The small intestine represents a significant part of the digestive system and plays a crucial role in the absorption of nutrients into the bloodstream. Smooth muscle cells of the small intestine are predominantly responsible for creating the contractions and relaxations that constitute intestinal motility. They trigger these movements in a coordinated and rhythmic manner known as peristalsis and segmentation. Peristalsis is a form of longitudinal and sequential contraction that pushes food from the upper gastrointestinal tract to the lower parts. Segmentation works by squeezing the intestine randomly, thereby facilitating the mixing of food particles and increasing contact with absorptive surfaces. These two processes are critical for intestinal motility and an effective digestive process. Apart from facilitating transit of food through contractions, these smooth muscle cells play a role in controlling the diameter of the vessels and the blood flow in the small intestine by their constrictive ability. These smooth muscle cells also contribute to the structural integrity of the small intestine by forming a part of its muscularis externa and muscularis mucosae. Additionally, they interact with other cell types such as enteric neurons and interstitial cells of Cajal (ICC), forming an integrated cellular network that ensures optimal functioning of the intestinal tract. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:15050" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of small intestine" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "smooth muscle cell of small intestine" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000275" ; rdfs:subClassOf obo:CL_0002504, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002504 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] ; foaf:depiction . obo:CL_1000276 obo:IAO_0000115 "A smooth muscle cell that is part of the duodenum." ; oboInOwl:hasDbXref "FMA:15058" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of duodenum" ; a owl:Class ; rdfs:label "smooth muscle fiber of duodenum" ; rdfs:subClassOf obo:CL_1000275, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001902 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000275 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] . obo:CL_1000277 obo:IAO_0000115 "A smooth muscle cell that is part of the jejunum." ; oboInOwl:hasDbXref "FMA:15062" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of jejunum" ; a owl:Class ; rdfs:label "smooth muscle fiber of jejunum" ; rdfs:subClassOf obo:CL_1000275, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002115 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000275 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002115 ] ) ] . obo:CL_1000278 obo:IAO_0000115 "A smooth muscle cell that is part of the ileum." ; terms:description """The smooth muscle fiber of the ileum primarily refers to a specific class of muscle cells present in the ileum, the final segment of the small intestine. Distinguished from skeletal muscle and cardiac muscle, smooth muscle does not possess striations and is under the control of the involuntary nervous system. These cells primarily facilitate the movement of digested food, a process known as peristalsis. These cells coordinate rhythmic contractions and relaxations, propelling the chyme toward the colon. This process is vital for efficient nutrient absorption in the small intestine and the transfer of undigested material to the large intestine. Moreover, the smooth muscle fibers enhance the ileum's ability to expand and adapt to volume changes without elevating internal pressure, known as compliance. The smooth muscle fiber of the ileum contributes to reflex responses, enhancing muscle contractions to propel intestinal contents in different physiological conditions. This involves intricate molecular signaling with neurotransmitters, hormones, and local signals. Thus, beyond its structural role, the smooth muscle fiber is crucial for the physiological functions of digestion and absorption in the small intestine. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:15066" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of ileum" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "smooth muscle fiber of ileum" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000278" ; rdfs:subClassOf obo:CL_1000275, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001902 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002116 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000275 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002116 ] ) ] . obo:CL_1000279 obo:IAO_0000115 "A smooth muscle cell that is part of the large intestine." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:15653" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of large intestine" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "smooth muscle cell of large intestine" ; rdfs:subClassOf obo:CL_0002504, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002504 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] . obo:CL_1000280 obo:IAO_0000115 "A smooth muscle cell that is part of the colon." ; oboInOwl:hasDbXref "FMA:15663" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of colon" ; a owl:Class ; rdfs:label "smooth muscle cell of colon" ; rdfs:subClassOf obo:CL_1000279, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001278 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002504 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:CL_1000281 obo:IAO_0000115 "A smooth muscle cell that is part of the cecum." ; oboInOwl:hasDbXref "FMA:15681" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of cecum", "smooth muscle fiber of cecum" ; a owl:Class ; rdfs:label "smooth muscle cell of cecum" ; rdfs:subClassOf obo:CL_1000280, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001153 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001153 ] ) ] . obo:CL_1000282 obo:IAO_0000115 "A smooth muscle cell that is part of the ascending colon." ; oboInOwl:hasDbXref "FMA:17518" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of ascending colon" ; a owl:Class ; rdfs:label "smooth muscle fiber of ascending colon" ; rdfs:subClassOf obo:CL_1000280, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001156 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000280 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001156 ] ) ] . obo:CL_1000283 obo:IAO_0000115 "A smooth muscle cell that is part of the transverse colon." ; oboInOwl:hasDbXref "FMA:17519" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of transverse colon" ; a owl:Class ; rdfs:label "smooth muscle fiber of transverse colon" ; rdfs:subClassOf obo:CL_1000280, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001157 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000280 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001157 ] ) ] . obo:CL_1000284 obo:IAO_0000115 "A smooth muscle cell that is part of the descending colon." ; oboInOwl:hasDbXref "FMA:17520" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of descending colon" ; a owl:Class ; rdfs:label "smooth muscle fiber of descending colon" ; rdfs:subClassOf obo:CL_1000280, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001158 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000280 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001158 ] ) ] . obo:CL_1000285 obo:IAO_0000115 "A smooth muscle cell that is part of the sigmoid colon." ; oboInOwl:hasDbXref "FMA:17521" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of sigmoid colon" ; a owl:Class ; rdfs:label "smooth muscle cell of sigmoid colon" ; rdfs:subClassOf obo:CL_1000280, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001159 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000280 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001159 ] ) ] . obo:CL_1000286 obo:IAO_0000115 "A smooth muscle cell that is part of the rectum." ; oboInOwl:hasDbXref "FMA:17522" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of rectum", "smooth muscle fiber of rectum" ; a owl:Class ; rdfs:label "smooth muscle cell of rectum" ; rdfs:subClassOf obo:CL_1000279, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001052 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001278 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001052 ] ) ] . obo:CL_1000287 obo:IAO_0000115 "A muscle cell that is part of the anterior internodal tract." ; oboInOwl:hasDbXref "FMA:223276" ; a owl:Class ; rdfs:label "myocyte of anterior internodal tract" ; rdfs:subClassOf obo:CL_0002096 . obo:CL_1000288 obo:IAO_0000115 "A muscle cell that is part of the atrial branch of anterior internodal tract." ; oboInOwl:hasDbXref "FMA:223277" ; a owl:Class ; rdfs:label "myocyte of atrial branch of anterior internodal tract" ; rdfs:subClassOf obo:CL_0002096 . obo:CL_1000289 obo:IAO_0000115 "A muscle cell that is part of the atrial septal branch of anterior internodal tract." ; oboInOwl:hasDbXref "FMA:223278" ; a owl:Class ; rdfs:label "myocyte of atrial septal branch of anterior internodal tract" ; rdfs:subClassOf obo:CL_0002096 . obo:CL_1000290 obo:IAO_0000115 "A muscle cell that is part of the middle internodal tract." ; oboInOwl:hasDbXref "FMA:223279" ; a owl:Class ; rdfs:label "myocyte of middle internodal tract" ; rdfs:subClassOf obo:CL_0002096 . obo:CL_1000291 obo:IAO_0000115 "A muscle cell that is part of the posterior internodal tract." ; oboInOwl:hasDbXref "FMA:223280" ; a owl:Class ; rdfs:label "myocyte of posterior internodal tract" ; rdfs:subClassOf obo:CL_0002096 . obo:CL_1000292 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002253 ; a owl:Class ; owl:deprecated true . obo:CL_1000293 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002254 ; a owl:Class ; owl:deprecated true . obo:CL_1000294 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002149 ; a owl:Class ; owl:deprecated true . obo:CL_1000295 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002231 ; a owl:Class ; owl:deprecated true . obo:CL_1000296 obo:IAO_0000115 "An epithelial cell that is part of the urethra." ; terms:description """Epithelial cells of the urethra constitute the inner lining of the urethra, forming a mucosal barrier that helps protect the body from external contaminants. The type of epithelial cells found in the urethra can vary along its length. In general, the urethra is lined with stratified squamous epithelium in its distal or external portion, which is closer to the external environment. This type of epithelium provides protection against mechanical stress and pathogens. Closer to the bladder, the urethra transitions to a different type of epithelium. In males, the proximal part of the urethra is lined with pseudostratified columnar epithelium in the region where it passes through the prostate gland. In females, the transitional epithelium may be present in the proximal part of the urethra near the bladder. Epithelial cells of the urethra are primarily dedicated to the protection of underlying tissues from mechanical stress and pathogens during micturition (urination). They do this by creating a tight, impermeable barrier that prevents the entry and colonization of invading microbes. They produce a variety of antimicrobials and are tightly packed to prevent infiltration between cells, forming an integral part of the body's innate immune system. In addition to their protective role, these cells are involved in the secretion of mucus. This mucus acts as a lubricant that ensures the smooth and easy passage of urine from the bladder through the urethra and out of the body, reducing any potential damage from the erosive action of urine. Epithelial cells of the urethra are dynamic, constantly renewing their numbers to replace any cells lost through wear and tear. Any disruptions to the function or integrity of these cells may contribute to urinary tract infections and other urological disorders. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:256165" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "epithelial cell of urethra" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000296" ; rdfs:subClassOf obo:CL_0000066, obo:CL_1001320 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:CL_1000297 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002257 ; a owl:Class ; owl:deprecated true . obo:CL_1000298 obo:IAO_0000115 "A mesothelial cell that is part of the dura mater." ; oboInOwl:hasDbXref "FMA:256516" ; oboInOwl:hasExactSynonym "squamous mesothelial cell of dura mater" ; a owl:Class ; rdfs:label "mesothelial cell of dura mater" ; rdfs:subClassOf obo:CL_0000077, obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002363 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002363 ] ) ] . obo:CL_1000299 obo:IAO_0000115 "A fibroblast that is part of the connective tissue of prostate." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:261271" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "fibroblast of connective tissue of prostate" ; rdfs:subClassOf obo:CL_0000057, obo:CL_0002622 ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" . obo:CL_1000300 obo:IAO_0000115 "A fibroblast that is part of the outer membrane of prostatic capsule." ; oboInOwl:hasDbXref "FMA:261273" ; a owl:Class ; rdfs:label "fibroblast of outer membrane of prostatic capsule" ; rdfs:subClassOf obo:CL_0000057, obo:CL_0002622 . obo:CL_1000301 obo:IAO_0000115 "A fibroblast that is part of the subepithelial connective tissue of prostatic gland." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:261275" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "fibroblast of subepithelial connective tissue of prostatic gland" ; rdfs:subClassOf obo:CL_0000057, obo:CL_0002622 ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" . obo:CL_1000302 obo:IAO_0000115 "A fibroblast that is part of the papillary layer of dermis." ; oboInOwl:hasDbXref "FMA:261277" ; a owl:Class ; rdfs:label "fibroblast of papillary layer of dermis" ; rdfs:subClassOf obo:CL_0002551, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001992 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002551 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001992 ] ) ] . obo:CL_1000303 obo:IAO_0000115 "A fibroblast that is part of the areolar connective tissue." ; oboInOwl:hasDbXref "FMA:261279" ; a owl:Class ; rdfs:label "fibroblast of areolar connective tissue" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006815 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006815 ] ) ] . obo:CL_1000304 obo:IAO_0000115 "A fibroblast that is part of the connective tissue of nonglandular part of prostate." ; oboInOwl:hasDbXref "FMA:261281" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "fibroblast of connective tissue of nonglandular part of prostate" ; rdfs:subClassOf obo:CL_0000057, obo:CL_0002622 . obo:CL_1000305 obo:IAO_0000115 "A fibroblast that is part of the connective tissue of glandular part of prostate." ; oboInOwl:hasDbXref "FMA:261283" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "fibroblast of connective tissue of glandular part of prostate" ; rdfs:subClassOf obo:CL_0000057, obo:CL_0002622 . obo:CL_1000306 obo:IAO_0000115 "A fibroblast that is part of the tunica adventitia of artery." ; oboInOwl:hasDbXref "FMA:261285" ; a owl:Class ; rdfs:label "fibroblast of tunica adventitia of artery" ; rdfs:subClassOf obo:CL_4052030, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007240 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007240 ] ) ] . obo:CL_1000307 obo:IAO_0000115 "A fibroblast that is part of the dense regular elastic tissue." ; oboInOwl:hasDbXref "FMA:261287" ; a owl:Class ; rdfs:label "fibroblast of dense regular elastic tissue" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002521 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007846 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007846 ] ) ] . obo:CL_1000308 obo:IAO_0000115 "A fibrocyte that is part of the adventitia of ureter." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:261289" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "fibrocyte of adventitia of ureter" ; rdfs:subClassOf obo:CL_0000135, obo:CL_1000708 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001252 ] ) ] . obo:CL_1000309 obo:IAO_0000115 "An adipocyte that is part of the epicardial fat." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:261293" ; oboInOwl:hasExactSynonym "adipocyte of epicardial fat", "epicardial fat cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "epicardial adipocyte" ; rdfs:subClassOf obo:CL_0000136, obo:CL_0002494, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002348 ] . obo:CL_1000310 obo:IAO_0000115 "An adipocyte that is part of the epicardial fat of right ventricle." ; oboInOwl:hasDbXref "FMA:261297" ; oboInOwl:hasExactSynonym "epicardial adipocyte of right ventricle", "epicardial fat cell of right ventricle" ; a owl:Class ; rdfs:label "adipocyte of epicardial fat of right ventricle" ; rdfs:subClassOf obo:CL_1000309, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002080 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000309 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002080 ] ) ] . obo:CL_1000311 obo:IAO_0000115 "An adipocyte that is part of the epicardial fat of left ventricle." ; oboInOwl:hasDbXref "FMA:261300" ; oboInOwl:hasExactSynonym "epicardial adipocyte of left ventricle", "epicardial fat cell of left ventricle" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "adipocyte of epicardial fat of left ventricle" ; rdfs:subClassOf obo:CL_1000309, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002084 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000309 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002084 ] ) ] . obo:CL_1000312 obo:IAO_0000115 "A goblet cell that is part of the epithelium of bronchus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Bronchial goblet cells are a subset of goblet cells that are predominantly found in the respiratory tract, specifically within the bronchi and bronchioles. Named for their flask-like shape and their apparent similarity to a goblet, these cells contribute significantly to the maintenance of lung health and homeostasis. In humans, goblet cells comprise up to 25% of the bronchial epithelial columnar cells and are an integral part of the mucus-secreting system of the respiratory tract and are primarily responsible for the production and secretion of mucus. The mucus secreted by bronchial goblet cells serves as a protective layer over the delicate and sensitive structures of the bronchi. The mucus, an amalgamation of glycoproteins, lipids, and other substances, traps any inhaled dust, microorganisms, and pollutants, preventing them from reaching deeper lung tissues and causing potential damage. Additionally, the mucus secretion aids in moistening the airway surface, thereby facilitating effective gas exchange and maintaining the overall health of the respiratory tract. Bronchial goblet cells have an innate defense mechanism wherein they increase secretion of mucus in response to irritants, infection or inflammation in the airway. This strategy, however, if incessantly stimulated, can lead to airway obstruction and health complications like asthma and chronic obstructive pulmonary disease (COPD). (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:263032" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of bronchus" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "The marker set PLCG2, ANKRD36C can identify the Human cell type bronchial goblet cell in the lung with a confidence of 0.55 (NS-Forest FBeta value)." ; rdfs:label "bronchial goblet cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000312" ; rdfs:subClassOf obo:CL_0002328, obo:CL_0019003, [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000026 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:CL_1000313 obo:IAO_0000115 "A goblet cell that is part of the epithelium of stomach." ; oboInOwl:hasDbXref "FMA:263035" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of stomach" ; a owl:Class ; rdfs:label "gastric goblet cell" ; rdfs:subClassOf obo:CL_0000160, obo:CL_0002180 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] . obo:CL_1000314 obo:IAO_0000115 "A goblet cell that is part of the epithelium of gastric cardiac gland." ; oboInOwl:hasDbXref "FMA:263038" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of gastric cardiac gland" ; a owl:Class ; rdfs:label "gastric cardiac gland goblet cell" ; rdfs:subClassOf obo:CL_0000152, obo:CL_0002659, obo:CL_1000313, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008859 ] ) ] ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008859 ] ) ] . obo:CL_1000315 obo:IAO_0000115 "A goblet cell that is part of the epithelium of principal gastric gland." ; oboInOwl:hasDbXref "FMA:263040" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of principal gastric gland" ; a owl:Class ; rdfs:label "principal gastric gland goblet cell" ; rdfs:subClassOf obo:CL_0000152, obo:CL_0002659, obo:CL_1000313, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009971 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009971 ] ) ] . obo:CL_1000316 obo:IAO_0000115 "OBSOLETE: A goblet cell that is part of the epithelium of small intestine." ; obo:IAO_0100001 obo:CL_1000495 ; oboInOwl:hasDbXref "FMA:263042" ; a owl:Class ; rdfs:label "obsolete goblet cell of epithelium of small intestine" ; owl:deprecated true . obo:CL_1000317 obo:IAO_0000115 "A goblet cell that is part of the epithelium of intestinal villus." ; oboInOwl:hasDbXref "FMA:263046" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of intestinal villus" ; a owl:Class ; rdfs:label "intestinal villus goblet cell" ; rdfs:subClassOf obo:CL_1000495, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013636 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013636 ] ) ] . obo:CL_1000318 obo:IAO_0000115 "A goblet cell that is part of the epithelium of crypt of lieberkuhn of small intestine." ; oboInOwl:hasDbXref "FMA:263050" ; a owl:Class ; rdfs:label "obsolete small intestine crypt goblet cell" ; owl:deprecated true . obo:CL_1000319 obo:IAO_0000115 "OBSOLETE: A goblet cell that is part of the epithelium proper of small intestine." ; oboInOwl:hasDbXref "FMA:263052" ; a owl:Class ; rdfs:label "obsolete goblet cell of epithelium proper of small intestine" ; owl:deprecated true . obo:CL_1000320 obo:IAO_0000115 "A goblet cell that is part of the epithelium of large intestine." ; terms:description """The large intestine goblet cell is a highly specialized type of mucosal epithelial cell that is located within the epithelial lining of the large intestine. The key function of goblet cells is the production and secretion of a protective layer of mucus which is essential for maintaining gut homeostasis. Goblet cells have a characteristic 'goblet-like' shape, which adapts them for this specific function: organelles such as the nucleus, mitochondria, ER, and Golgi apparatus are located in the basal portion of the cell; while the vesicles with mucins (required for mucus production) are located apically, close to the apical membrane where their exocytosis takes place. The goblet cells of the large intestine produce a thick layer of mucus that coats the intestinal lumen. This mucus provides a barrier that prevents the direct contact of intestinal cells with bacteria and other potentially toxic substances present in the digestive tract. It also lubricates the intestine to facilitate the smooth passage of digested food material. It is worth noting that the mucus system differs between the small and large intestine: although in both the mucus is built around MUC2 mucin polymers produced by goblet cells, it is becoming clear that there are several types of goblet cells that function in different ways. From an immunological perspective, large intestine goblet cells participate in promoting a balanced gut immune response. They contribute to the process known as immune tolerance, where they prevent the body's immune system from overreacting to the trillions of bacteria present in the gut. These cells achieve this by secreting molecules that help maintain a calm environment, limiting inflammatory reactions unless absolutely necessary. Any dysfunction or decrease in the number of goblet cells can result in a compromised intestinal barrier leading to various health issues, including inflammatory bowel disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:263054" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of large intestine" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "large intestine goblet cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000320" ; rdfs:subClassOf obo:CL_0002253, obo:CL_0019031 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001278 ] ) ] . obo:CL_1000321 obo:IAO_0000115 "A goblet cell that is part of the epithelium of crypt of Lieberkuhn of large intestine." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:263056" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "large intestine crypt goblet cell" ; rdfs:subClassOf obo:CL_0002658, obo:CL_1000320, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0022281 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0022281 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/large-intestine-crypt-lieberkuhn/v1.2/assets/2d-ftu-large-intestine-crypt-lieberkuhn.png" . obo:CL_1000322 obo:IAO_0000115 "A goblet cell that is part of the epithelium of pancreatic duct." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:263058" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of pancreatic duct" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreatic goblet cell" ; rdfs:subClassOf obo:CL_0000069, obo:CL_0000160, obo:CL_1001599, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009970 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-pancreatic-acinus/v1.2/assets/2d-ftu-pancreas-pancreatic-acinus.png" . obo:CL_1000323 obo:IAO_0000115 "A goblet cell that is part of the epithelium of pyloric gland." ; oboInOwl:hasDbXref "FMA:263061" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of pyloric gland" ; a owl:Class ; rdfs:label "pyloric gastric gland goblet cell" ; rdfs:subClassOf obo:CL_0000152, obo:CL_0002659, obo:CL_1000313, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001276 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008861 ] ) ] ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008861 ] ) ] . obo:CL_1000324 obo:IAO_0000115 "A goblet cell that is part of the epithelium proper of duodenum." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:263063" ; oboInOwl:hasExactSynonym "goblet cell of epithelium proper of duodenum" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "duodenal goblet cell" ; rdfs:subClassOf obo:CL_1000317, obo:CL_1001589 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008346 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/small-intestine-villus/v1.0/assets/2d-ftu-small-intestine-villus.png" . obo:CL_1000325 obo:IAO_0000115 "A goblet cell that is part of the epithelium proper of jejunum." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:263065" ; oboInOwl:hasExactSynonym "goblet cell of epithelium proper of jejunum" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "jejunal goblet cell" ; rdfs:subClassOf obo:CL_1000317, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000400 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000400 ] ) ] . obo:CL_1000326 obo:IAO_0000115 "A goblet cell that is part of the epithelium proper of ileum." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """The ileal goblet cell is a subset of intestinal goblet cells that are a key component of the epithelium of the ileum, a portion of the small intestine. Goblet cells are named and characterized by their distinctive 'goblet' shape with a narrow base tapering to a broad apical surface; located between the lumen of the intestine and the internal environment of the body, they serve an integral role in maintaining gut homeostasis. Like all intestinal goblet cells, the primary function of ileal goblet cells is the production and secretion of mucins, large, heavily glycosylated proteins that combine to form mucus. This mucus lining serves as a protective barrier, shielding the underlying tissue from the potentially damaging effects of digestive enzymes, acids, or pathogenic microbes present in the gut lumen. Their strategic location in the ileal segment of the intestinal tract aids in efficient nutrient absorption while also maintaining an impregnable barrier against potential pathogens, ensuring an intricate balance. Goblet cells of the ileum also play a significant role in immune modulation. They are thought to promote oral tolerance (the immune unresponsiveness to orally ingested antigens such as food) by delivering luminal antigens to underlying dendritic cells, thereby driving immune education and tolerogenic responses. They also secrete bioactive molecules, such as the trefoil factor peptide TFF3, which aids in repairing damaged epithelium. By performing these crucial functions, ileal goblet cells not only aid in maintaining intestinal health, but also contribute significantly to the overall well-being of the organism. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:263067" ; oboInOwl:hasExactSynonym "goblet cell of epithelium proper of ileum" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "ileal goblet cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000326" ; rdfs:subClassOf obo:CL_1000317, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008345 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008345 ] ) ] . obo:CL_1000327 obo:IAO_0000115 "A goblet cell that is part of the epithelium proper of appendix." ; oboInOwl:hasDbXref "FMA:263069" ; oboInOwl:hasExactSynonym "goblet cell of epithelium proper of appendix" ; a owl:Class ; rdfs:label "appendix goblet cell" ; rdfs:subClassOf obo:CL_1000320, obo:CL_1000405 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009697 ] ) ] . obo:CL_1000328 obo:IAO_0000115 "OBSOLETE: A goblet cell that is part of the epithelium proper of large intestine." ; oboInOwl:hasDbXref "FMA:263071" ; a owl:Class ; rdfs:label "obsolete goblet cell of epithelium proper of large intestine" ; owl:deprecated true . obo:CL_1000329 obo:IAO_0000115 "A goblet cell that is part of the epithelium of trachea." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Tracheal goblet cells are specialized cells found in the lining of the trachea. They are a key component of the tracheobronchial epithelium, a critical region responsible for maintaining open airways and preventing the ingress of harmful particles or irritants. Goblet cells are filled with membrane-bound secretory granules, which are responsible for their distinctive, goblet-like shape. Goblet cells specialize in the production and secretion of mucus, a slimy substance composed primarily of glycoproteins (mucins) and water. This sticky mucus serves to trap foreign particles and pollutants, such as dust, bacteria, and viruses that an organism breathes in. After trapping these particles, the cilia on neighboring ciliated epithelial cells beat synchronously, forming a coordinated escalator to push mucus upwards toward the pharynx, where it's either swallowed or expectorated. This system, known as the mucociliary clearance or escalator, forms a crucial barrier in the lungs against respiratory pathogens and external insults. Changes in the number or function of tracheal goblet cells can engender health complications. For example, goblet cell hyperplasia, or excessive growth of goblet cells, is a common feature of chronic inflammatory lung diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD). This condition results in mucus hypersecretion, airway blockage, and increased risk of respiratory tract infections. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:263075" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of trachea" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "tracheal goblet cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000329" ; rdfs:subClassOf obo:CL_0000307, obo:CL_0019003, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001901 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] . obo:CL_1000330 obo:IAO_0000115 "A serous secreting cell that is part of the epithelium of trachea." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Serous cells are specialized epithelial cells and can be found lining the trachea and brochus. They are among the major components of the respiratory epithelium. These cells are known for their production and release of serous secretions, which form a key component of airway mucus. These secretions primarily comprise of water, proteins, and enzymes, such as lysozyme and peroxidases. Their main purposes are to provide hydration and lubrication to the airway tissue and to act as a defense mechanism against pathogens. While the lysozyme and peroxidases contribute to the destruction of bacteria, the water in the secretions helps to liquefy the mucus, facilitating the effective functioning of the ciliated cells that propel the mucus up the trachea. The coordinated action between serous cells and other cell types in the tracheal epithelium proves essential for maintaining a healthy respiratory tract. Dysfunction or damage of these cells can lead to various respiratory tract disorders, such as cystic fibrosis and asthma. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:263078" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "serous cell of epithelium of trachea" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000330" ; rdfs:subClassOf obo:CL_0019001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001901 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000313 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001901 ] ) ] . obo:CL_1000331 obo:IAO_0000115 "A serous secreting cell that is part of the epithelium of bronchus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Serous cells of the epithelium of the bronchus, also termed bronchial serous cells, are predominantly found within the seromucous glands located in the bronchial submucosa. Serous cells can also be found in the trachea and are characterized by small, sparse, electron-dense granules. Serous cells are specialized cells responsible for the production and secretion of serous fluid. Serous fluid, mainly composed of water, proteins, and various types of salts, provides many benefits: it helps moisturize the airways, keep the bronchial tube walls moist, and safeguard the bronchial tubes against various foreign particles and infectious agents such as bacteria and viruses. Moreover, the fluid released by these cells assists in the lubrication and reduced friction in the bronchi, allowing for smoother airflow. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:263080" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "serous cell of epithelium of bronchus" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000331" ; rdfs:subClassOf obo:CL_0019001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002031 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000313 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002031 ] ) ] . obo:CL_1000332 obo:IAO_0000115 "A serous secreting cell that is part of the epithelium of terminal bronchiole." ; oboInOwl:hasDbXref "FMA:263082" ; a owl:Class ; rdfs:label "serous cell of epithelium of terminal bronchiole" ; rdfs:subClassOf obo:CL_0019001, obo:CL_1000272, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001958 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000313 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001958 ] ) ] . obo:CL_1000333 obo:IAO_0000115 "A serous secreting cell that is part of the epithelium of bronchiole." ; oboInOwl:hasDbXref "FMA:263084" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "serous cell of epithelium of lobular bronchiole" ; rdfs:subClassOf obo:CL_0019001, obo:CL_1000272, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8600001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000313 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8600001 ] ) ] . obo:CL_1000334 obo:IAO_0000115 "An enterocyte that is part of the epithelium of small intestine." ; terms:description """Enterocytes of the epithelium of the small intestine are specialized cells that reside in the lining of the small intestine, and are primarily responsible for the essential process of nutrient absorption. These cells are columnar epithelial cells with an apical surface lined with microvilli, a feature referred to as the 'brush border', to maximize the surface area available for absorption. Enterocytes play a critical role in both the digestion and absorption of nutrients from food. Their extensive brush border contains enzymes that further assist in nutrient breakdown and transport proteins that transfer nutrients, such as glucose, amino acids, lipids, and vitamins, across the cell membrane. The enterocytes of the small intestine also participate in the barrier function of the gut lining. Enterocytes are connected by tight junctions, which act as a primary defense line against pathogenic invasion by maintaining intestinal barrier integrity. Additionally, their cell surface is coated in glycocalyx and mucus which forms a defensive barrier preventing the penetration of harmful bacteria into the systemic circulation. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:263086" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "enterocyte of epithelium of small intestine" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000334" ; rdfs:subClassOf obo:CL_0000584, obo:CL_0002254, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001902 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000584 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001902 ] ) ] ; foaf:depiction . obo:CL_1000335 obo:IAO_0000115 "An enterocyte that is part of the epithelium of intestinal villus." ; oboInOwl:hasDbXref "FMA:263088" ; a owl:Class ; rdfs:label "enterocyte of epithelium of intestinal villus" ; rdfs:subClassOf obo:CL_1000334, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013636 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000584 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013636 ] ) ] . obo:CL_1000336 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_1000346 ; a owl:Class ; owl:deprecated true . obo:CL_1000337 obo:IAO_0000115 "An enterocyte that is part of the epithelium of duodenal gland." ; oboInOwl:hasDbXref "FMA:263092" ; a owl:Class ; rdfs:label "enterocyte of epithelium of duodenal gland" ; rdfs:subClassOf obo:CL_1000334, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001212 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000584 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001212 ] ) ] . obo:CL_1000338 obo:IAO_0000115 "An enterocyte that is part of the epithelium of crypt of Lieberkuhn of small intestine." ; oboInOwl:hasDbXref "FMA:263094" ; a owl:Class ; rdfs:label "enterocyte of epithelium of crypt of Lieberkuhn of small intestine" ; rdfs:subClassOf obo:CL_1000334, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001983 ] . obo:CL_1000339 obo:IAO_0000115 "An enterocyte that is part of the epithelium proper of small intestine." ; oboInOwl:hasDbXref "FMA:263096" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "enterocyte of epithelium proper of small intestine" ; rdfs:subClassOf obo:CL_1000334 . obo:CL_1000340 obo:IAO_0000115 "An enterocyte that is part of the epithelium proper of duodenum." ; oboInOwl:hasDbXref "FMA:263098" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "enterocyte of epithelium proper of duodenum" ; rdfs:subClassOf obo:CL_1000339, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] . obo:CL_1000341 obo:IAO_0000115 "An enterocyte that is part of the epithelium proper of jejunum." ; oboInOwl:hasDbXref "FMA:263100" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "enterocyte of epithelium proper of jejunum" ; rdfs:subClassOf obo:CL_1000339 . obo:CL_1000342 obo:IAO_0000115 "An enterocyte that is part of the epithelium proper of ileum." ; terms:description """Enterocytes of the epithelium proper of the ileum, commonly known as ileal enterocytes, are specialized epithelial cells found lining the inner surface of the ileum, the final section of the small intestine in the human body. They play a pivotal role in nutrient absorption, digestive metabolic functions, and the maintenance of the host’s immune response. Like enterocytes in other parts of the intestine, ileal enterocytes exhibit distinct characteristics specific to their function and role. They have microvilli on their apical surfaces to increase absorption and are important in the absorption of vitamins and the reabsorption of bile salts. These cells also produce enzymes that metabolize lipids and xenobiotics. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:263102" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "enterocyte of epithelium proper of ileum" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000342" ; rdfs:subClassOf obo:CL_1000339 . obo:CL_1000343 obo:IAO_0000115 "A paneth cell that is part of the epithelium of small intestine." ; terms:description """Paneth cells of the epithelium of the small intestine, often referred to simply as Paneth cells, are a type of specialized secretory cell that forms an integral part of the intestinal crypts of Lieberkühn – gland-like invaginations lining the small intestine. Named after the Austrian physician Josef Paneth, who first identified them in the late 19th century, these cells are significant because of their substantial involvement in the mucosal immune system and intestinal stem cell maintenance. Functionally, Paneth cells play a key role in maintaining gut homeostasis and in the first line of antimicrobial defense, mainly through the secretion of a range of antimicrobial peptides and proteins. These include lysozymes, cryptdins, or alpha-defensins, which have potent activity against various gut pathogens including bacteria, fungi, and parasites. Furthermore, Paneth cells of the small intestine are also known to release secretory phospholipase A2, an enzyme active against gram-positive bacteria. Additionally, they secrete several growth factors like EGF, TGF-alpha, and Wnt3, which are crucial for stem cell support and the overall maintenance of intestinal mucosal integrity. The unique location of Paneth cells at the base of the crypts positions them in very close proximity to intestinal stem cells. This not only facilitates their role in stem cell maintenance but also involves them in epithelial regeneration and repair following injury. Dysfunctional Paneth cells have been associated with several gut disorders, like Crohn’s disease and necrotizing enterocolitis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:263104" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "paneth cell of epithelium of small intestine" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000343" ; rdfs:subClassOf obo:CL_0000510, obo:CL_1001598 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000510 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001902 ] ) ] ; foaf:depiction . obo:CL_1000344 obo:IAO_0000115 "A Paneth cell that is part of the epithelium proper of small intestine." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:263106" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "paneth cell of epithelium proper of small intestine" ; rdfs:subClassOf obo:CL_1000343 . obo:CL_1000345 obo:IAO_0000115 "A paneth cell that is part of the epithelium of crypt of Lieberkuhn of small intestine." ; oboInOwl:hasDbXref "FMA:263108" ; a owl:Class ; rdfs:label "paneth cell of epithelium of crypt of Lieberkuhn of small intestine" ; rdfs:subClassOf obo:CL_1000343 . obo:CL_1000346 obo:IAO_0000115 "An enterocyte that is part of the epithelium proper of large intestine." ; oboInOwl:hasDbXref "FMA:263090", "FMA:263112" ; oboInOwl:hasNarrowSynonym "vacuolar absorptive cell of epithelium proper of large intestine" ; a owl:Class ; rdfs:label "enterocyte of epithelium proper of large intestine" ; rdfs:subClassOf obo:CL_0002071 . obo:CL_1000347 obo:IAO_0000115 "An enterocyte (absorptive epithelial cell) of the colonic epithelium, characterized by a columnar shape. This cell is responsible for the absorption, transport, and metabolization of short-chain fatty acids (SCFAs) produced by gut bacteria, as well as the transport and absorption of water and electrolytes." ; terms:description """Enterocytes of the colon are specialized epithelial cells located in the lining of the colon, the largest part of the large intestine. These cells play a critical role in absorbing water, electrolytes, and certain vitamins from the food material passed on from the small intestine. With a unique structure of finger-like protrusions referred to as microvilli, the enterocytes increase their surface area for effective absorption. The colon is the last part of the digestive system, and as such, it is responsible for compacting undigested food materials and forming fecal matter. Enterocytes of the colon facilitate this process effectively through absorption of water. Enterocytes are known for their high regeneration potential, replenishing every 4-5 days, enabling the healthy functioning of the colon. They originate from stem cells located in the crypt of the colon and differentiate into mature enterocytes as they migrate upwards towards the luminal surface. This constant turnover aids in maintaining the intestinal barrier, preventing the entry of detrimental substances into the systemic circulation. Their tight junctions with other epithelial cells provide a robust barrier against invasive pathogens. Enterocytes of the colon are involved in the communication with the gut microbiota. These cells harbor enzymes necessary for the metabolism of short-chain fatty acids, which are the byproducts of the fermentation process by gut bacteria. Short-chain fatty acids serve as a major energy source for colonocytes and are important for maintaining colonic health. The dysfunction of enterocytes, therefore, could lead to disorders such as inflammatory bowel disease or colorectal cancer. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:263114" ; oboInOwl:hasExactSynonym "enterocyte of colon" ; oboInOwl:hasNarrowSynonym "vacuolar absorptive cell of epithelium of colon" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "colonocyte" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000347" ; rdfs:subClassOf obo:CL_0002071, obo:CL_0011108, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0019626 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035377 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002071 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000397 ] ) ] . obo:CL_1000348 obo:IAO_0000115 "A basal cell that is part of the epithelium of trachea." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Basal cells of epithelium of trachea are a vital cell population within the respiratory tract's lining, specifically in the trachea's epithelium. These cells are located at the base of the columnar epithelial cell layer and can be identified by their characteristic cuboidal shape, a large nucleus and few organelles, as well as scattered microvilli. The basal cells are not in direct contact with the lumen, which is covered by a layer of ciliated and non-ciliated columnar cells. Instead, the basal cells are connected to, and line, a thin basement membrane. The primary function of basal cells involves stem cell activity and epithelial tissue maintenance. Basal cells in the trachea play a crucial role in the regeneration and repair of the tracheal epithelium during damage or injury, acting as progenitor cells for ciliated and secretory cells. They serve as a reserve pool of cells, ready to proliferate and differentiate as needed for homeostatic tissue maintenance or in repair processes when the epithelium has been compromised, whether by injury or disease. These cells are also implicated in numerous disease pathways. Conditions like chronic obstructive pulmonary disease and lung cancer exhibit unusual behavior and quantities of tracheal basal cells, making these cells a focal point in respiratory disease research. In summary, basal cells in the tracheal epithelium have a multifaceted role in maintaining, repairing, and influencing tracheal health, playing a crucial role in the stability of the respiratory system. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:263118" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "basal cell of epithelium of trachea" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000348" ; rdfs:subClassOf obo:CL_0002633, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001901 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002633 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001901 ] ) ] . obo:CL_1000349 obo:IAO_0000115 "A basal cell found in the bronchus epithelium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """The basal cells of the epithelium of the bronchus are a vital component of the cellular linings found within the bronchial tubes of the respiratory system. They are typically nonciliated, cuboidal cells that are tightly attached to the basement membrane, thereby providing structural support for the epithelial tissues. The function of the basal cell of the bronchial epithelium is multifaceted, underscoring the importance of these cells for respiratory health. One of their primary roles involves regeneration and cellular turnover. They serve as local stem cells, being able to proliferate and differentiate into other cell types such as ciliated and secretory epithelial cells. This regenerative function of basal cells is required for maintaining the integrity of the bronchial epithelium and is especially critical after injury or during disease states when there is an increased need for new cells to repair damaged tissue or replace lost cells. In addition to these regenerative duties, basal cells of the bronchial epithelium play a crucial role in providing a defensive barrier against inhaled substances. They participate in the coordinated immune response directed against airborne pathogens, foreign particles, and toxins that enter the respiratory tract. Basal cells can respond to inflammation or irritation by altering their activities, which include proliferating, differentiating, or producing bioactive substances. Throughout all these responses, the basal cells help to maintain the homeostasis of the bronchial tubes, allowing for the efficient transport of air to and from the lungs. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:263120" ; oboInOwl:hasExactSynonym "basal cell of bronchus" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "basal cell of epithelium of bronchus" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000349" ; rdfs:subClassOf obo:CL_0002328, obo:CL_0002329, obo:CL_0002633 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002633 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002031 ] ) ] . obo:CL_1000350 obo:IAO_0000115 "A basal cell that is part of the epithelium of terminal bronchiole." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:263122" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "basal cell of epithelium of terminal bronchiole" ; rdfs:subClassOf obo:CL_0002633, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001958 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002633 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001958 ] ) ] . obo:CL_1000351 obo:IAO_0000115 "A basal cell that is part of the epithelium of respiratory bronchiole." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:263124" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "basal cell of epithelium of respiratory bronchiole" ; rdfs:subClassOf obo:CL_0002633, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001955 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002633 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001955 ] ) ] . obo:CL_1000352 obo:IAO_0000115 "A basal cell that is part of the epithelium of bronchiole." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:263126" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "basal cell of epithelium of lobular bronchiole" ; rdfs:subClassOf obo:CL_0002633, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8600001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002633 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8600001 ] ) ] . obo:CL_1000353 obo:IAO_0000115 "A M cell that is part of the epithelium of small intestine." ; terms:description """Microfold cells, also widely known as M cells, are a distinct type of epithelial cell found in the gut, including the small intestine, specifically within the Peyer’s patches, a component of the gut-associated lymphoid tissue (GALT). M cells play a crucial role in the immune response within the intestine environment. These cells are characterized by microfolds (short microvilli, which give them their name), a reduced, thin glycocalyx, and a deeply invaginated basolateral membrane next to immune cells such as B cells, T cells, and macrophages, and DCs. These features allow the M cells to form the first point of contact between the gut lumen and the intestinal immune system. They are well-regulated gateways that capture and transport antigens, such as bacteria, viruses, and other foreign substances found in the lumen, to the underlying cells of the immune system. This specialized transport mechanism, called ‘transcytosis’, involves engulfment of these antigens from the apical side, transport across their cytoplasm, and release on the basolateral side of the cells, where immune responses can be initiated. Furthermore, M cells have complex interactions with members of the gut microbiota and other immune cells, making them essential for maintaining gut homeostasis. This cross-talk shapes the diversity and makeup of the gut microbiota, subsequently having a substantial impact on the host's health. In certain situations, pathogenic organisms can exploit the transcytosis mechanism to infiltrate the host's system, causing various infectious diseases. The overarching significance of M cells in the small intestine lies in their role of surveillance and protection against a wide range of potentially harmful pathogens, while also facilitating beneficial interactions with commensal microbes. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:263128" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "microfold cell of epithelium of small intestine" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000353" ; rdfs:subClassOf obo:CL_0000682, obo:CL_0002254, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001902 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000682 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:CL_1000354 obo:IAO_0000115 "A M cell that is part of the epithelium of intestinal villus." ; oboInOwl:hasDbXref "FMA:263130" ; a owl:Class ; rdfs:label "microfold cell of epithelium of intestinal villus" ; rdfs:subClassOf obo:CL_1000353, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013636 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000682 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001213 ] ) ] . obo:CL_1000355 obo:IAO_0000115 "A M cell that is part of the epithelium proper of small intestine." ; oboInOwl:hasDbXref "FMA:263132" ; a owl:Class ; rdfs:label "microfold cell of epithelium proper of small intestine" ; rdfs:subClassOf obo:CL_1000353 . obo:CL_1000356 obo:IAO_0000115 "A M cell that is part of the epithelium proper of duodenum." ; oboInOwl:hasDbXref "FMA:263134" ; a owl:Class ; rdfs:label "microfold cell of epithelium proper of duodenum" ; rdfs:subClassOf obo:CL_1000354, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008346 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000682 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] . obo:CL_1000357 obo:IAO_0000115 "A M cell that is part of the epithelium proper of jejunum." ; oboInOwl:hasDbXref "FMA:263136" ; a owl:Class ; rdfs:label "microfold cell of epithelium proper of jejunum" ; rdfs:subClassOf obo:CL_1000353, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002115 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000682 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002115 ] ) ] . obo:CL_1000358 obo:IAO_0000115 "A M cell that is part of the epithelium proper of ileum." ; oboInOwl:hasDbXref "FMA:263138" ; a owl:Class ; rdfs:label "microfold cell of epithelium proper of ileum" ; rdfs:subClassOf obo:CL_1000353, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002116 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000682 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002116 ] ) ] . obo:CL_1000359 obo:IAO_0000115 "A M cell that is part of the epithelium proper of appendix." ; oboInOwl:hasDbXref "FMA:263140" ; a owl:Class ; rdfs:label "microfold cell of epithelium proper of appendix" ; rdfs:subClassOf obo:CL_1000360, obo:CL_1000405 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000682 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ) ] . obo:CL_1000360 obo:IAO_0000115 "A M cell that is part of the epithelium proper of large intestine." ; oboInOwl:hasDbXref "FMA:263142" ; a owl:Class ; rdfs:label "microfold cell of epithelium proper of large intestine" ; rdfs:subClassOf obo:CL_0000682, obo:CL_0002253 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000682 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] . obo:CL_1000361 obo:IAO_0000115 "A transitional myocyte that is part of the interatrial septum." ; oboInOwl:hasDbXref "FMA:263152" ; a owl:Class ; rdfs:label "transitional myocyte of interatrial septum" ; rdfs:subClassOf obo:CL_0002073, obo:CL_2000022, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002085 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002073 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002085 ] ) ] . obo:CL_1000362 obo:IAO_0000115 "A transitional myocyte that is part of the interventricular septum." ; oboInOwl:hasDbXref "FMA:263154" ; a owl:Class ; rdfs:label "transitional myocyte of interventricular septum" ; rdfs:subClassOf obo:CL_0002073, obo:CL_2000022, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002094 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002073 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002094 ] ) ] . obo:CL_1000363 obo:IAO_0000115 "A transitional myocyte that is part of the atrial branch of anterior internodal tract." ; oboInOwl:hasDbXref "FMA:263156" ; a owl:Class ; rdfs:label "transitional myocyte of atrial branch of anterior internodal tract" ; rdfs:subClassOf obo:CL_1000480 . obo:CL_1000364 obo:IAO_0000115 "A transitional myocyte that is part of the anterior internodal tract." ; oboInOwl:hasDbXref "FMA:263158" ; a owl:Class ; rdfs:label "transitional myocyte of anterior internodal tract" ; rdfs:subClassOf obo:CL_1000480 . obo:CL_1000365 obo:IAO_0000115 "A transitional myocyte that is part of the atrial septal branch of anterior internodal tract." ; oboInOwl:hasDbXref "FMA:263160" ; a owl:Class ; rdfs:label "transitional myocyte of atrial septal branch of anterior internodal tract" ; rdfs:subClassOf obo:CL_1000480 . obo:CL_1000366 obo:IAO_0000115 "A transitional myocyte that is part of the middle internodal tract." ; oboInOwl:hasDbXref "FMA:263162" ; a owl:Class ; rdfs:label "transitional myocyte of middle internodal tract" ; rdfs:subClassOf obo:CL_1000480 . obo:CL_1000367 obo:IAO_0000115 "A transitional myocyte that is part of the posterior internodal tract." ; oboInOwl:hasDbXref "FMA:263164" ; a owl:Class ; rdfs:label "transitional myocyte of posterior internodal tract" ; rdfs:subClassOf obo:CL_1000480 . obo:CL_1000368 obo:IAO_0000115 "A transitional myocyte that is part of the anterior division of left branch of atrioventricular bundle." ; oboInOwl:hasDbXref "FMA:263166" ; a owl:Class ; rdfs:label "transitional myocyte of anterior division of left branch of atrioventricular bundle" ; rdfs:subClassOf obo:CL_1000370 . obo:CL_1000369 obo:IAO_0000115 "A transitional myocyte that is part of the septal division of left branch of atrioventricular bundle." ; oboInOwl:hasDbXref "FMA:263168" ; a owl:Class ; rdfs:label "transitional myocyte of septal division of left branch of atrioventricular bundle" ; rdfs:subClassOf obo:CL_1000370 . obo:CL_1000370 obo:IAO_0000115 "A transitional myocyte that is part of the left branch of atrioventricular bundle." ; oboInOwl:hasDbXref "FMA:263170" ; a owl:Class ; rdfs:label "transitional myocyte of left branch of atrioventricular bundle" ; rdfs:subClassOf obo:CL_1000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005986 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002073 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005986 ] ) ] . obo:CL_1000371 obo:IAO_0000115 "A transitional myocyte that is part of the right branch of atrioventricular bundle." ; oboInOwl:hasDbXref "FMA:263172" ; a owl:Class ; rdfs:label "transitional myocyte of right branch of atrioventricular bundle" ; rdfs:subClassOf obo:CL_1000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005987 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002073 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005987 ] ) ] . obo:CL_1000372 obo:IAO_0000115 "A transitional myocyte that is part of the atrial part of atrioventricular bundle." ; oboInOwl:hasDbXref "FMA:263174" ; a owl:Class ; rdfs:label "transitional myocyte of atrial part of atrioventricular bundle" ; rdfs:subClassOf obo:CL_1000481 . obo:CL_1000373 obo:IAO_0000115 "A transitional myocyte that is part of the ventricular part of atrioventricular bundle." ; oboInOwl:hasDbXref "FMA:263176" ; a owl:Class ; rdfs:label "transitional myocyte of ventricular part of atrioventricular bundle" ; rdfs:subClassOf obo:CL_1000481 . obo:CL_1000374 obo:IAO_0000115 "A transitional myocyte that is part of the posterior division of left branch of atrioventricular bundle." ; oboInOwl:hasDbXref "FMA:263178" ; a owl:Class ; rdfs:label "transitional myocyte of posterior division of left branch of atrioventricular bundle" ; rdfs:subClassOf obo:CL_1000370 . obo:CL_1000375 obo:IAO_0000115 "A myocardial endocrine cell that is part of the septal division of left branch of atrioventricular bundle." ; oboInOwl:hasDbXref "FMA:263180" ; a owl:Class ; rdfs:label "myocardial endocrine cell of septal division of left branch of atrioventricular bundle" ; rdfs:subClassOf obo:CL_0002074, obo:CL_0008009, obo:CL_0010007, obo:CL_2000046, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005986 ] . obo:CL_1000376 obo:IAO_0000115 "A Purkinje myocyte that is part of the interventricular septum." ; oboInOwl:hasDbXref "FMA:263182" ; a owl:Class ; rdfs:label "Purkinje myocyte of interventricular septum" ; rdfs:subClassOf obo:CL_0002068, obo:CL_2000022, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002094 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002068 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002094 ] ) ] . obo:CL_1000377 obo:IAO_0000115 "A Feyrter cell that is part of the epithelium of trachea." ; oboInOwl:hasDbXref "FMA:263184" ; a owl:Class ; rdfs:label "dense-core granulated cell of epithelium of trachea" ; rdfs:subClassOf obo:CL_0000307, obo:CL_0002066, obo:CL_0008055, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001901 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001901 ] ) ] . obo:CL_1000378 obo:IAO_0000115 "A type I vestibular sensory cell that is part of the stato-acoustic epithelium." ; oboInOwl:hasDbXref "FMA:263186" ; a owl:Class ; rdfs:label "type 1 vestibular sensory cell of stato-acoustic epithelium" ; rdfs:subClassOf obo:CL_0002070, obo:CL_3000004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009969 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002070 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009969 ] ) ] . obo:CL_1000379 obo:IAO_0000115 "A type I vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth." ; oboInOwl:hasDbXref "FMA:263188" ; a owl:Class ; rdfs:label "type 1 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth" ; rdfs:subClassOf obo:CL_0002070, obo:CL_3000004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003241 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002070 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002214 ] ) ] . obo:CL_1000380 obo:IAO_0000115 "A type I vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth." ; oboInOwl:hasDbXref "FMA:263190" ; a owl:Class ; rdfs:label "type 1 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth" ; rdfs:subClassOf obo:CL_0002070, obo:CL_3000004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002212 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003242 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002070 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002212 ] ) ] . obo:CL_1000381 obo:IAO_0000115 "A type I vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth." ; oboInOwl:hasDbXref "FMA:263192" ; a owl:Class ; rdfs:label "type 1 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth" ; rdfs:subClassOf obo:CL_0002070, obo:CL_3000004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006935 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002070 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006935 ] ) ] . obo:CL_1000382 obo:IAO_0000115 "A type II vestibular sensory cell that is part of the stato-acoustic epithelium." ; oboInOwl:hasDbXref "FMA:263194" ; a owl:Class ; rdfs:label "type 2 vestibular sensory cell of stato-acoustic epithelium" ; rdfs:subClassOf obo:CL_0002069, obo:CL_3000004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009969 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002069 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009969 ] ) ] . obo:CL_1000383 obo:IAO_0000115 "A type II vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth." ; oboInOwl:hasDbXref "FMA:263196" ; a owl:Class ; rdfs:label "type 2 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth" ; rdfs:subClassOf obo:CL_0002069, obo:CL_3000004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003241 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002069 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002214 ] ) ] . obo:CL_1000384 obo:IAO_0000115 "A type II vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth." ; oboInOwl:hasDbXref "FMA:263198" ; a owl:Class ; rdfs:label "type 2 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth" ; rdfs:subClassOf obo:CL_0002069, obo:CL_3000004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002212 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003242 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002069 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002212 ] ) ] . obo:CL_1000385 obo:IAO_0000115 "A type II vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth." ; oboInOwl:hasDbXref "FMA:263200" ; a owl:Class ; rdfs:label "type 2 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth" ; rdfs:subClassOf obo:CL_0002069, obo:CL_3000004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006935 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002069 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006935 ] ) ] . obo:CL_1000386 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002205 ; a owl:Class ; owl:deprecated true . obo:CL_1000387 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002203 ; a owl:Class ; owl:deprecated true . obo:CL_1000388 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002207 ; a owl:Class ; owl:deprecated true . obo:CL_1000389 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002208 ; a owl:Class ; owl:deprecated true . obo:CL_1000390 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002206 ; a owl:Class ; owl:deprecated true . obo:CL_1000391 obo:IAO_0000115 "A melanocyte that is part of the eyelid." ; oboInOwl:hasDbXref "FMA:59175" ; oboInOwl:hasExactSynonym "eyelid melanocyte", "sebaceous gland of wolff" ; a owl:Class ; rdfs:label "melanocyte of eyelid" ; rdfs:subClassOf obo:CL_0000148, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001711 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001711 ] ) ] . obo:CL_1000393 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002543 ; a owl:Class ; owl:deprecated true . obo:CL_1000394 obo:IAO_0000115 "A myoepithelial cell that is part of the intralobular part of terminal lactiferous duct." ; oboInOwl:hasDbXref "FMA:62158" ; a owl:Class ; rdfs:label "myoepithelial cell of intralobular lactiferous duct" ; rdfs:subClassOf obo:CL_0000185 . obo:CL_1000395 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002169 ; a owl:Class ; owl:deprecated true . obo:CL_1000396 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000362 ; a owl:Class ; owl:deprecated true . obo:CL_1000397 obo:IAO_0000115 "An endothelial cell that is part of the venous sinus of red pulp of spleen." ; oboInOwl:hasDbXref "FMA:62817" ; a owl:Class ; rdfs:comment "todo - add logical definition to UBERON:0009967" ; rdfs:label "endothelial cell of venous sinus of red pulp of spleen" ; rdfs:subClassOf obo:CL_0002651, obo:CL_2000053, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009967 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009967 ] ) ] . obo:CL_1000398 obo:IAO_0000115 "An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Endothelial cells of hepatic sinusoids, also known as hepatic or liver sinusoidal endothelial cells (HSEC or LSEC), are unique, specialized type of endothelial cells located in the liver. They are the building units of the hepatic sinusoid, which functions as a specialized capillary system that facilitates the exchange of various substances between the blood and hepatocytes. This finely tuned environment, facilitated by HSEC, is primordial for the liver's multiple physiologic functions that include nutrient metabolism, toxin inactivation, and immunomodulation. The HSEC have a distinctive morphology that sets them apart from the typical endothelial cells found in other organs. These cells are exceptionally thin to allow for efficient transfer of molecules and characterized by fenestrations, which are non-diaphragmatic, sieve-like openings that provide an open filtration pathway from the sinusoidal lumen to the space of Disse, where hepatocytes are exposed. The fenestration is a crucial feature that allows lipoproteins, nutrients, and other plasma components easy access to hepatocytes for essential liver functions, including clearance of waste products and metabolic regulation. HSECs further play a vital role in immune functionality in the liver. They act as a sentinel, determining the nature of the immune response to encountered particulates. They possess a capacity for antigen presentation and express a series of immune-related surface molecules, which helps in immunosurveillance and immunoregulation. The HSEC also aid in the removal and destruction of virus-infected cells, harmful microorganisms, and circulatory waste products to safeguard liver health and general systemic cleanliness. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:000125", "FMA:62911" ; oboInOwl:hasExactSynonym "LSEC", "endotheliocyte of hepatic sinusoid", "liver sinusoidal endothelial cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "endothelial cell of hepatic sinusoid" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000398" ; rdfs:subClassOf obo:CL_0000666, obo:CL_0002262, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001281 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001281 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" . obo:CL_1000399 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002178 ; a owl:Class ; owl:deprecated true . obo:CL_1000400 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002183 ; a owl:Class ; owl:deprecated true . obo:CL_1000401 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002181 ; a owl:Class ; owl:deprecated true . obo:CL_1000402 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002252 ; a owl:Class ; owl:deprecated true . obo:CL_1000403 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002262 ; a owl:Class ; owl:deprecated true . obo:CL_1000404 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002180 ; a owl:Class ; owl:deprecated true . obo:CL_1000405 obo:IAO_0000115 "An epithelial cell that is part of the appendix." ; oboInOwl:hasDbXref "FMA:63602" ; oboInOwl:hasExactSynonym "columnar epitheliocyte of appendix", "epithelial cell of vermiform appendix" ; a owl:Class ; rdfs:label "epithelial cell of appendix" ; rdfs:subClassOf obo:CL_0002253, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009697 ] ; owl:equivalentClass _:genid14932 . obo:CL_1000406 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002320 ; a owl:Class ; owl:deprecated true . obo:CL_1000407 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002202 ; a owl:Class ; owl:deprecated true . obo:CL_1000408 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002231 ; a owl:Class ; owl:deprecated true . obo:CL_1000409 obo:IAO_0000115 "A muscle cell that is part of the sinoatrial node." ; oboInOwl:hasDbXref "FMA:67102" ; oboInOwl:hasExactSynonym "SA nodal myocyte", "SA node cardiac muscle cell", "sinoatrial node cell", "sinoatrial node myocyte", "sinuatrial node myocyte" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "myocyte of sinoatrial node" ; rdfs:subClassOf obo:CL_0002072, obo:CL_0008009, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002351 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002351 ] ) ] . obo:CL_1000410 obo:IAO_0000115 "A muscle cell that is part of the atrioventricular node." ; oboInOwl:hasDbXref "FMA:67106" ; oboInOwl:hasExactSynonym "AV nodal myocyte", "AV node cardiac muscle cell", "AV node cell", "atrioventricular node cell", "atrioventricular node myocyte" ; a owl:Class ; rdfs:label "myocyte of atrioventricular node" ; rdfs:subClassOf obo:CL_0002072, obo:CL_0008009, obo:CL_2000022, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002352 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002352 ] ) ] . obo:CL_1000411 obo:IAO_0000115 "An endothelial cell that is part of the small intestine Peyer's patch." ; oboInOwl:hasDbXref "FMA:67757" ; a owl:Class ; rdfs:label "endothelial cell of Peyer's patch" ; rdfs:subClassOf obo:CL_0000131, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003454 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003454 ] ) ] . obo:CL_1000412 obo:IAO_0000115 "An endothelial cell that is part of the arteriole." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:67760", "KUPO:0001097" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "endothelial cell of arteriole" ; rdfs:subClassOf obo:CL_0000071, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001980 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001980 ] ) ] . obo:CL_1000413 obo:IAO_0000115 "A blood vessel endothelial cell that is part of an arterial endothelium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Endothelial cells of the artery, also referred to as arterial endothelial cells, form an integral part of the arterial system. They form a single layer, known as the endothelium, lining the interior surface of arteries, and are able to respond to the high-pressure and flow conditions present in arteries. The primary role of these cells is to provide a barrier between the vessel wall and the blood, exhibiting selective permeability to regulate the movement of liquids, gases, and blood-borne substances across the vascular wall. Arterial endothelial cells significantly contribute to maintaining vascular homeostasis. They are at the forefront of sensations and responses to mechanical stimuli, like shear stress and blood pressure changes. An additional key function pertains to the production of nitric oxide, which helps to regulate vascular tone and blood pressure, prevents platelet aggregation, limits leukocyte adhesion to the endothelium, and inhibits smooth muscle cell proliferation. These varied but connected functions help to preclude the development of atherosclerosis, ensuring normal circulation and arterial health. Moreover, these cells play a pivotal role in inflammation and coagulation processes. During inflammatory events, they express various adhesion molecules, aiding in leukocyte recruitment and rolling onto the vessel walls for immune response. They also produce anticoagulant and procoagulant substances, involved in blood clotting and clot dissolution, respectively. Dysregulation of the usual functions of arterial endothelial cells can result in serious pathophysiological conditions, such as atherosclerosis, hypertension, and other cardiovascular diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "BTO:0004758", "FMA:67761", "KUPO:0001095" ; oboInOwl:hasExactSynonym "arterial endothelial cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "endothelial cell of artery" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000413" ; rdfs:subClassOf obo:CL_0000071, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001917 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001637 ] ) ] . obo:CL_1000414 obo:IAO_0000115 "An endothelial cell that is part of the venule." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:67762" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "endothelial cell of venule" ; rdfs:subClassOf obo:CL_0000071, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001979 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002139 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001979 ] ) ] . obo:CL_1000415 obo:IAO_0000115 "An epithelial cell that is part of the gallbladder." ; oboInOwl:hasDbXref "FMA:67780" ; a owl:Class ; rdfs:label "epithelial cell of gallbladder" ; rdfs:subClassOf obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002110 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002110 ] ) ] . obo:CL_1000416 obo:IAO_0000115 "OBSOLETE. A myoepithelial cell that is part of the mammary gland." ; obo:IAO_0100001 obo:CL_0002324 ; a owl:Class ; rdfs:comment "Term merged into CL:0002324 (myoepithelial cell of mammary gland)" ; rdfs:label "obsolete myoepithelial cell of lactiferous gland" ; owl:deprecated true . obo:CL_1000417 obo:IAO_0000115 "A myoepithelial cell that is part of the sweat gland." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:67801" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "myoepithelial cell of sweat gland" ; rdfs:subClassOf obo:CL_0000185, obo:CL_1000448 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000185 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001820 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-hair-follicle/v1.0/assets/2d-ftu-skin-hair-follicle.png" . obo:CL_1000418 obo:IAO_0000115 "A myoepithelial cell that is part of the mammary gland alveolus." ; oboInOwl:hasDbXref "FMA:67802" ; oboInOwl:hasExactSynonym "basal cell of alveolus of lactiferous gland", "myoepithelial cell of mammary alveolus" ; a owl:Class ; rdfs:label "myoepithelial cell of lactiferous alveolus" ; rdfs:subClassOf obo:CL_0002324, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003214 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000185 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003214 ] ) ] . obo:CL_1000419 obo:IAO_0000115 "A myoepithelial cell that is part of the lactiferous duct." ; oboInOwl:hasDbXref "FMA:67803" ; a owl:Class ; rdfs:label "myoepithelial cell of lactiferous duct" ; rdfs:subClassOf obo:CL_0000068, obo:CL_0002324, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001765 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000185 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001765 ] ) ] . obo:CL_1000420 obo:IAO_0000115 "A myoepithelial cell that is part of the terminal lactiferous duct." ; oboInOwl:hasDbXref "FMA:67804" ; a owl:Class ; rdfs:label "myoepithelial cell of terminal lactiferous duct" ; rdfs:subClassOf obo:CL_0000185 . obo:CL_1000421 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002138 ; a owl:Class ; owl:deprecated true . obo:CL_1000422 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000336 ; a owl:Class ; owl:deprecated true . obo:CL_1000423 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002099 ; a owl:Class ; owl:deprecated true . obo:CL_1000424 obo:IAO_0000115 "A chromaffin cell that is part of the paraaortic body." ; oboInOwl:hasDbXref "FMA:69328" ; oboInOwl:hasExactSynonym "chromaffin cell of para-aortic body" ; a owl:Class ; rdfs:label "chromaffin cell of paraaortic body" ; rdfs:subClassOf obo:CL_1000425, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001237 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001237 ] ) ] . obo:CL_1000425 obo:IAO_0000115 "A chromaffin cell that is part of the paraganglion." ; oboInOwl:hasDbXref "FMA:69335" ; a owl:Class ; rdfs:label "chromaffin cell of paraganglion" ; rdfs:subClassOf obo:CL_0000166, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012279 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012279 ] ) ] . obo:CL_1000426 obo:IAO_0000115 "A chromaffin cell that is part of the adrenal gland." ; oboInOwl:hasDbXref "FMA:69794" ; oboInOwl:hasExactSynonym "adrenal chromaffin cell" ; a owl:Class ; rdfs:label "chromaffin cell of adrenal gland" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000166, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002369 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002369 ] ) ] . obo:CL_1000427 obo:IAO_0000115 "A chromaffin cell that is part of the adrenal cortex." ; oboInOwl:hasDbXref "FMA:69795" ; oboInOwl:hasExactSynonym "chromaffin cell of adrenal cortex" ; a owl:Class ; rdfs:comment "Not clear this cell type exists. Can't call it a cortical adrenal cell because of different germ layer origin." ; rdfs:label "adrenal cortex chromaffin cell" ; rdfs:subClassOf obo:CL_1000426, obo:CL_1001601 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001235 ] ) ] . obo:CL_1000428 obo:IAO_0000115 "A somatic stem cell that is part of the epidermis." ; oboInOwl:hasDbXref "FMA:70541", "ZFA:0007122" ; oboInOwl:hasExactSynonym "epidermal stem cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "stem cell of epidermis" ; rdfs:subClassOf obo:CL_0000723, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000723 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] ) ] . obo:CL_1000429 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002260 ; a owl:Class ; owl:deprecated true . obo:CL_1000430 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000706 ; a owl:Class ; owl:deprecated true . obo:CL_1000431 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000575 ; a owl:Class ; owl:deprecated true . obo:CL_1000432 obo:IAO_0000115 "An epithelial cell that is part of the conjunctiva." ; oboInOwl:hasDbXref "FMA:70552" ; oboInOwl:hasExactSynonym "epithelial cell of conjunctiva" ; oboInOwl:inSubset cl:cellxgene_subset, cl:eye_upper_slim ; a owl:Class ; rdfs:label "conjunctival epithelial cell" ; rdfs:subClassOf obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001811 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001811 ] ) ] . obo:CL_1000433 obo:IAO_0000115 "An epithelial cell that is part of the lacrimal canaliculus." ; oboInOwl:hasDbXref "FMA:70553" ; a owl:Class ; rdfs:label "epithelial cell of lacrimal canaliculus" ; rdfs:subClassOf obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001770 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001770 ] ) ] . obo:CL_1000434 obo:IAO_0000115 "An epithelial cell that is part of the external acoustic meatus." ; oboInOwl:hasDbXref "FMA:70555" ; a owl:Class ; rdfs:label "epithelial cell of external acoustic meatus" ; rdfs:subClassOf obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001352 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001352 ] ) ] . obo:CL_1000435 obo:IAO_0000115 "An epithelial cell that is part of the lacrimal drainage system." ; oboInOwl:hasDbXref "FMA:70559" ; oboInOwl:hasRelatedSynonym "epithelial cell of lacrimal duct" ; a owl:Class ; rdfs:label "epithelial cell of lacrimal drainage system" ; rdfs:subClassOf obo:CL_0000072, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001850 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000068 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001850 ] ) ] . obo:CL_1000436 obo:IAO_0000115 "An epithelial cell that is part of the lacrimal sac." ; terms:description """Epithelial cells of the lacrimal sac play a significant role in the physiology of tear drainage, acting as an integral part of the lacrimal drainage system. The lacrimal sac is part of the nasolacrimal duct system, a conduit which connects the eye to the nasal cavity, and is lined by multilayered, non-keratinizing, squamous epithelial cells. The epithelial cells of the lacrimal sac are specialized for the purpose of maintaining a moist environment and protecting the surface of the eye. They form a barrier that traps and removes potential contaminants from the tear film during the drainage process. These cells also actively contribute to tear turnover by expediting the drainage of excess tears. Dysfunctional epithelial cells of the lacrimal sac can lead to dacryocystitis, a condition characterized by inflammation of the lacrimal sac. Epithelial cells of the lacrimal sac also perform various other tasks which ensure the overall health of the eye. They are involved in the regulation of immune responses within the lacrimal apparatus and may have a possible role in host-microbiome interactions. Thus, epithelial cells of the lacrimal sac play a multifaceted role in tear drainage and ocular surface defence, directly translating to eye health and vision quality. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:70560" ; a owl:Class ; rdfs:label "epithelial cell of lacrimal sac" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000436" ; rdfs:subClassOf obo:CL_1000437, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001351 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001351 ] ) ] . obo:CL_1000437 obo:IAO_0000115 "An epithelial cell that is part of the nasolacrimal duct." ; oboInOwl:hasDbXref "FMA:70561" ; a owl:Class ; rdfs:label "epithelial cell of nasolacrimal duct" ; rdfs:subClassOf obo:CL_1000435, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002392 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000072 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002392 ] ) ] . obo:CL_1000438 obo:IAO_0000115 "An epithelial cell that is part of the wall of inferior part of anal canal." ; oboInOwl:hasDbXref "FMA:70562" ; a owl:Class ; rdfs:label "epithelial cell of wall of inferior part of anal canal" ; rdfs:subClassOf obo:CL_0002634 . obo:CL_1000439 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002187 ; a owl:Class ; owl:deprecated true . obo:CL_1000440 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002283 ; a owl:Class ; owl:deprecated true . obo:CL_1000441 obo:IAO_0000115 "An epithelial cell that is part of the viscerocranial mucosa." ; oboInOwl:hasDbXref "FMA:70583" ; a owl:Class ; rdfs:label "epithelial cell of viscerocranial mucosa" ; rdfs:subClassOf obo:CL_0000066 . obo:CL_1000442 obo:IAO_0000115 "An urothelial cell that is part of the trigone of urinary bladder." ; oboInOwl:hasDbXref "FMA:70598" ; oboInOwl:hasExactSynonym "epithelial cell of vesical trigone" ; a owl:Class ; rdfs:label "urothelial cell of trigone of urinary bladder" ; rdfs:subClassOf obo:CL_1001428, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000365 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001257 ] ) ] ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000731 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000365 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001257 ] ) ] ] ) ] . obo:CL_1000443 obo:IAO_0000115 "A smooth muscle cell that is part of the ciliary body." ; terms:description """Ciliary muscle cells are specialized contractile cells that constitute the ciliary muscle, a component of the eye in vertebrates. These cells form a ring around the iris, the eye's colored part. Ciliary muscle cells fall into the category of smooth muscle cells, characterized by their lack of the striations typical of skeletal and cardiac muscle cells. Their shape is elongated and pointed at both ends, and they occur in multi-nucleated syncytia where many cells share the same cytoplasm. Ciliary muscle cells primarily control the eye's accommodation, adjusting the thickness and curvature of the lens to fine-tune the focus of light on the retina. When ciliary muscle cells contract, tension on the zonular fibers holding the lens in place is reduced, allowing the lens to become thicker and increase its refractive power. Conversely, when the ciliary muscle cells relax, the tension on the zonular fibers increases, causing the lens to become flatter and decrease its refractive power. This adjustment facilitates clear vision at different distances, ranging from near to far objects. Additionally, ciliary muscle cells play a role in draining the eye's aqueous humor, which is the clear fluid that fills the anterior chamber of the eye between the cornea and the lens. By controlling the shape of the surrounding trabecular meshwork through muscle contractions and relaxations, ciliary muscle cells indirectly regulate intraocular pressure, a factor critical for preventing ocular conditions like glaucoma. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:70610" ; oboInOwl:hasExactSynonym "smooth muscle cell of ciliary body" ; oboInOwl:inSubset cl:cellxgene_subset, cl:eye_upper_slim ; a owl:Class ; rdfs:label "ciliary muscle cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000443" ; rdfs:subClassOf obo:CL_0000192, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001775 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001775 ] ) ] . obo:CL_1000444 obo:IAO_0000115 "A mesothelial cell that is part of the anterior chamber of eyeball." ; oboInOwl:hasDbXref "FMA:70615" ; a owl:Class ; rdfs:label "mesothelial cell of anterior chamber of eye" ; rdfs:subClassOf obo:CL_0000077, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001766 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001766 ] ) ] . obo:CL_1000445 obo:IAO_0000115 "A myoepithelial cell that is part of the dilatator pupillae." ; oboInOwl:hasDbXref "FMA:70619" ; a owl:Class ; rdfs:label "myoepithelial cell of dilator pupillae" ; rdfs:subClassOf obo:CL_0000185, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001608 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000185 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001608 ] ) ] . obo:CL_1000446 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002261 ; a owl:Class ; owl:deprecated true . obo:CL_1000447 obo:IAO_0000115 "A basal cell that is part of the epithelium of esophagus." ; oboInOwl:hasDbXref "FMA:70731" ; oboInOwl:hasExactSynonym "basal cell of esophageal epithelium" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "epithelial cell of stratum germinativum of esophagus" ; rdfs:subClassOf obo:CL_0000646, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001976 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000646 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001976 ] ) ] . obo:CL_1000448 obo:IAO_0000115 "An epithelial cell that is part of the sweat gland." ; oboInOwl:hasDbXref "FMA:70952" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "epithelial cell of sweat gland" ; rdfs:subClassOf obo:CL_0000362, obo:CL_0002308, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001820 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001820 ] ) ] . obo:CL_1000449 obo:IAO_0000115 "An epithelial cell that is part of the nephron." ; terms:description """Epithelial cells of the nephron form the epithelial lining of the nephron, the functional unit of the kidney that filters the blood to produce urine. Each kidney holds approximately one million nephrons, each of which is composed of several distinct parts, including the renal corpuscle, the proximal tubule, the loop of Henle, and the distal tubule. All sections are lined with highly specialized epithelial cells adapted to perform different functions within the sections of the nephron. The different epithelial cells of the nephron play crucial roles in the process of filtration, reabsorption, secretion, and excretion, essential tasks for the regulation of body fluid composition and volume. During filtration, the blood is forced through the walls of glomerular capillaries into the Bowman's capsule, where waste products, electrolytes, and water are separated from the blood cells and proteins. As the filtrate then passes through the nephron, epithelial cells of the tubular portion reabsorb useful substances such as glucose, amino acids, and electrolytes, along with most of the water back into the bloodstream. Waste products like urea and creatinine, as well as excess ions and water, remain in the tubule for elimination. In addition, epithelial cells of the nephron also play a vital part in maintaining the body's acid-base balance by actively secreting hydrogen ions into the urine while reabsorbing bicarbonate from the urine back into the blood. They are also involved in the regulation of blood pressure through the renin-angiotensin-aldosterone system and contribute to erythrocyte production by releasing the hormone erythropoietin in response to low oxygen levels in the blood. Abnormalities or damage in renal epithelial cells often result in impaired kidney function, leading to various renal diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:70965" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "epithelial cell of nephron" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000449" ; rdfs:subClassOf obo:CL_0002518, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001285 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001285 ] ) ] . obo:CL_1000450 obo:IAO_0000115 "An epithelial cell that is part of the glomerular capsule." ; oboInOwl:hasDbXref "FMA:70966", "KUPO:0001034" ; oboInOwl:hasExactSynonym "Bowmans capsule epithelial cell", "epithelial cell of Bowman's capsule" ; oboInOwl:inSubset cl:cellxgene_subset, cl:kidney_upper_slim ; a owl:Class ; rdfs:label "epithelial cell of glomerular capsule" ; rdfs:subClassOf obo:CL_1000510, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001230 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001230 ] ) ] . obo:CL_1000451 obo:IAO_0100001 obo:CL_0000653 ; a owl:Class ; rdfs:label "obsolete epithelial cell of visceral layer of glomerular capsule" ; owl:deprecated true . obo:CL_1000452 obo:IAO_0000115 "An epithelial cell that is part of the glomerular parietal epithelium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:70968", "KUPO:0001035" ; oboInOwl:hasExactSynonym "epithelial cell of parietal layer of glomerular capsule" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "parietal epithelial cell" ; rdfs:subClassOf obo:CL_1000450, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005750 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005750 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" . obo:CL_1000453 obo:IAO_0000115 "An epithelial cell that is part of the intermediate tubule." ; oboInOwl:hasDbXref "FMA:70980" ; a owl:Class ; rdfs:label "epithelial cell of intermediate tubule" ; rdfs:subClassOf obo:CL_1000909, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004136 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000494 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004136 ] ) ] . obo:CL_1000454 obo:IAO_0000115 "An epithelial cell that is part of the collecting duct of renal tubule." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Kidney collecting duct epithelial cells are a specialized type of cells that form an integral part of the renal system. Located in the collecting duct system of the kidneys, these cells are responsible for one of the final steps in the process of urine formation, and they are instrumental in the fine tuning of the volume and composition of urine by reabsorbing water and certain solutes back into the bloodstream. These cells express specific channels and carriers that actively and passively transport ions and water. They also have channels on their membranes, such as sodium channels and potassium channels, involved in reabsorbing or secreting these electrolytes depending upon the body's needs. The function of renal collecting duct epithelial cells can be regulated by a variety of hormones, including vasopressin (antidiuretic hormone), which can modulate the ion channels and carriers and hence indirectly influence body fluid homeostasis. Aside from their function in ion and water balance, kidney collecting duct epithelial cells also aid in maintaining the body's acid-base balance. They have specialized functionality to secret hydrogen ions into the tubular lumen, which contributes to acid excretion. Any dysfunction may have serious implications and lead to various renal or systemic diseases, exemplifying the importance of these cells in maintaining overall body homeostasis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:70982", "KUPO:0001059" ; oboInOwl:hasExactSynonym "epithelial cell of renal collecting tubule" ; oboInOwl:inSubset cl:cellxgene_subset, cl:kidney_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney collecting duct epithelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000454" ; rdfs:subClassOf obo:CL_0000072, obo:CL_1000449, obo:CL_1001225 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001232 ] ) ] . obo:CL_1000456 obo:IAO_0000115 "A mesothelial cell that is part of the parietal peritoneum." ; oboInOwl:hasDbXref "FMA:72142" ; a owl:Class ; rdfs:label "mesothelial cell of parietal peritoneum" ; rdfs:subClassOf obo:CL_1000490, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001366 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001366 ] ) ] . obo:CL_1000457 obo:IAO_0000115 "A mesothelial cell that is part of the visceral peritoneum." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:72143" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mesothelial cell of visceral peritoneum" ; rdfs:subClassOf obo:CL_1000490, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001178 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001178 ] ) ] . obo:CL_1000458 obo:IAO_0000115 "A melanocyte that is part of the skin of body." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Melanocytes of the skin are specialized pigment cells crucial for producing and distributing melanin, the pigment determining skin, in addition to hair and eye color. Located in the basal layer of the epidermis, melanocytes serve as a natural sunscreen, protecting skin cells from harmful UV radiation. Structurally dendritic, they synthesize melanin through melanogenesis, transferring melanosomes to keratinocytes for UV shielding Beyond pigmentation and UV protection, melanocytes play roles in immune and inflammatory responses. They respond to environmental changes, communicate with skin cell types, and secrete cytokines and growth factors influencing skin homeostasis. Dysregulation may lead to pigment disorders like vitiligo and melasma or contribute to skin cancer, particularly malignant melanoma. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "CALOHA:TS-2374", "FMA:72144" ; oboInOwl:hasExactSynonym "skin melanocyte" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "melanocyte of skin" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000458" ; rdfs:subClassOf obo:CL_0000148, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002097 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002097 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-epidermal-ridge/v1.2/assets/2d-ftu-skin-epidermal-ridge.png" . obo:CL_1000459 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002293 ; a owl:Class ; owl:deprecated true . obo:CL_1000461 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002233 ; a owl:Class ; owl:deprecated true . obo:CL_1000462 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002232 ; a owl:Class ; owl:deprecated true . obo:CL_1000463 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002236 ; a owl:Class ; owl:deprecated true . obo:CL_1000464 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002234 ; a owl:Class ; owl:deprecated true . obo:CL_1000465 obo:IAO_0000115 "A chromaffin cell that is part of the ovary." ; oboInOwl:hasDbXref "FMA:74319" ; a owl:Class ; rdfs:label "chromaffin cell of ovary" ; rdfs:subClassOf obo:CL_0000166, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] . obo:CL_1000466 obo:IAO_0000115 "A chromaffin cell that is part of the right ovary." ; oboInOwl:hasDbXref "FMA:74320" ; a owl:Class ; rdfs:label "chromaffin cell of right ovary" ; rdfs:subClassOf obo:CL_1000465, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002118 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002118 ] ) ] . obo:CL_1000467 obo:IAO_0000115 "A chromaffin cell that is part of the left ovary." ; oboInOwl:hasDbXref "FMA:74321" ; a owl:Class ; rdfs:label "chromaffin cell of left ovary" ; rdfs:subClassOf obo:CL_1000465, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002119 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002119 ] ) ] . obo:CL_1000468 obo:IAO_0000115 "A myoepithelial cell that is part of the acinus of lactiferous gland." ; oboInOwl:hasDbXref "FMA:74469" ; oboInOwl:hasExactSynonym "basal cell of acinus of lactiferous gland" ; a owl:Class ; rdfs:label "myoepithelial cell of acinus of lactiferous gland" ; rdfs:subClassOf obo:CL_0002324, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001912 ] . obo:CL_1000469 obo:IAO_0000115 "A myoepithelial cell that is part of the main lactiferous duct." ; oboInOwl:hasDbXref "FMA:74499" ; a owl:Class ; rdfs:label "myoepithelial cell of main lactiferous duct" ; rdfs:subClassOf obo:CL_0000185 . obo:CL_1000470 obo:IAO_0000115 "A myoepithelial cell that is part of the primary lactiferous duct." ; oboInOwl:hasDbXref "FMA:74500" ; a owl:Class ; rdfs:label "myoepithelial cell of primary lactiferous duct" ; rdfs:subClassOf obo:CL_0000185 . obo:CL_1000471 obo:IAO_0000115 "A myoepithelial cell that is part of the secondary lactiferous duct." ; oboInOwl:hasDbXref "FMA:74501" ; a owl:Class ; rdfs:label "myoepithelial cell of secondary lactiferous duct" ; rdfs:subClassOf obo:CL_0000185 . obo:CL_1000472 obo:IAO_0000115 "A myoepithelial cell that is part of the tertiary lactiferous duct." ; oboInOwl:hasDbXref "FMA:74502" ; a owl:Class ; rdfs:label "myoepithelial cell of tertiary lactiferous duct" ; rdfs:subClassOf obo:CL_0000185 . obo:CL_1000473 obo:IAO_0000115 "A myoepithelial cell that is part of the quarternary lactiferous duct." ; oboInOwl:hasDbXref "FMA:74503" ; a owl:Class ; rdfs:label "myoepithelial cell of quarternary lactiferous duct" ; rdfs:subClassOf obo:CL_0000185 . obo:CL_1000474 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0000307 ; a owl:Class ; owl:deprecated true . obo:CL_1000475 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002350 ; a owl:Class ; owl:deprecated true . obo:CL_1000476 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_0002325 ; a owl:Class ; owl:deprecated true . obo:CL_1000477 obo:IAO_0000115 "A nodal myocyte that is part of the sinoatrial node." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:83383" ; oboInOwl:hasExactSynonym "cardiac pacemaker cell of sinuatrial node", "pacemaker cell of sinoatrial node", "pacemaker cell of sinuatrial node" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cardiac pacemaker cell of sinoatrial node" ; rdfs:subClassOf obo:CL_1000409 . obo:CL_1000478 obo:IAO_0000115 "A transitional myocyte that is part of the sinoatrial node." ; oboInOwl:hasDbXref "FMA:83384" ; oboInOwl:hasExactSynonym "transitinal myocyte of sinuatrial node" ; a owl:Class ; rdfs:label "transitional myocyte of sinoatrial node" ; rdfs:subClassOf obo:CL_0002073, obo:CL_1000409 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002073 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002351 ] ) ] . obo:CL_1000479 obo:IAO_0000115 "A Purkinje myocyte that is part of the atrioventricular node." ; oboInOwl:hasDbXref "FMA:83386" ; a owl:Class ; rdfs:label "Purkinje myocyte of atrioventricular node" ; rdfs:subClassOf obo:CL_0002068, obo:CL_1000410 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002068 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002352 ] ) ] . obo:CL_1000480 obo:IAO_0000115 "A transitional myocyte that is part of the internodal tract." ; oboInOwl:hasDbXref "FMA:83387" ; a owl:Class ; rdfs:label "transitional myocyte of internodal tract" ; rdfs:subClassOf obo:CL_0002073, obo:CL_0002096 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002073 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009966 ] ) ] . obo:CL_1000481 obo:IAO_0000115 "A transitional myocyte that is part of the atrioventricular bundle." ; oboInOwl:hasDbXref "FMA:83388" ; a owl:Class ; rdfs:label "transitional myocyte of atrioventricular bundle" ; rdfs:subClassOf obo:CL_0002073, obo:CL_0008009, obo:CL_0010005, obo:CL_2000046 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002073 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002353 ] ) ] . obo:CL_1000482 obo:IAO_0000115 "A myocardial endocrine cell that is part of the interventricular septum." ; oboInOwl:hasDbXref "FMA:83390" ; a owl:Class ; rdfs:label "myocardial endocrine cell of interventricular septum" ; rdfs:subClassOf obo:CL_0002074, obo:CL_2000022, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002094 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002074 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002094 ] ) ] . obo:CL_1000483 obo:IAO_0000115 "A Purkinje myocyte that is part of the internodal tract." ; oboInOwl:hasDbXref "FMA:83392" ; a owl:Class ; rdfs:label "Purkinje myocyte of internodal tract" ; rdfs:subClassOf obo:CL_0002068, obo:CL_0002096 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002068 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009966 ] ) ] . obo:CL_1000484 obo:IAO_0000115 "A Purkinje myocyte that is part of the atrioventricular bundle." ; oboInOwl:hasDbXref "FMA:83393" ; a owl:Class ; rdfs:label "Purkinje myocyte of atrioventricular bundle" ; rdfs:subClassOf obo:CL_0002068, obo:CL_0008009, obo:CL_0010005, obo:CL_2000046 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002068 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002353 ] ) ] . obo:CL_1000486 obo:IAO_0000115 "A basal cell that is part of the urothelium. Compared to other urothelial cell types, a basal cell of the urothelium is positioned along the basement membrane, is the most undifferentiated and serves a progenitor role." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:84150" ; oboInOwl:hasExactSynonym "urothelial basal cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "It has been noted in at least some mammalian species that the urothelial basal cell type is distinguished by expression of high levels of cytokeratin-5 (CK5), p63 and the signalling molecule Sonic hedgehog (Shh). Similar to intermediate cells, the urothelial basal cell type expresses CK17 but is negative for uroplakins (UPK) and CK20. Urothelial basal cells have also been noted to be smaller in diameter than urothelial intermediate cells." ; rdfs:label "basal cell of urothelium" ; rdfs:subClassOf obo:CL_0000646, obo:CL_0000731 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000646 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000365 ] ) ] . obo:CL_1000487 obo:IAO_0000115 "A smooth muscle cell that is part of the prostate gland." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Smooth muscle cells of the prostate constitute a critical component of the prostatic stroma, enveloping glandular structures to support functions like secretion and fluid expulsion. Like other smooth muscles, smooth muscle cells of the prostate lack the striations characteristic of skeletal and cardiac muscle cell. Functionally, they play a crucial role in reproductive and urinary functions. Smooth muscle cells of the prostate contribute to the transport and expulsion of prostatic secretions into the urethra and respond dynamically to signaling molecules such as hormones and neurotransmitters. For instance, under sympathetic nervous stimulation, they contract and apply pressure on the gland's ducts, facilitating the secretion process. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:84583" ; oboInOwl:hasExactSynonym "smooth muscle fiber of prostate" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "smooth muscle cell of prostate" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000487" ; rdfs:subClassOf obo:CL_0000192, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" . obo:CL_1000488 obo:IAO_0000115 "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." ; terms:description """Cholangiocytes, also known as biliary epithelial cells, are specialized epithelial cells that line the biliary tract, which constitutes the gall bladder and bile ducts inside the liver. Crucial to the maintenance of the liver's health and function, cholangiocytes have a key role in the modification and secretion of bile, a fluid produced by hepatocytes that is essential to digestion and the absorption of fats and vitamins. Cholangiocytes accomplish their primary function through the expression of a variety of transport proteins located on their apical and basolateral membranes, which propel bile acids and other contents of the bile into the biliary lumen. The hepatic bile, once secreted by the hepatocytes, is further modified by cholangiocytes via secretion and absorption processes. These processes help in the regulation of bile volume and composition, which is fundamental in ensuring the efficient digestion of dietary fats and fat-soluble vitamins and the excretion of cholesterol. In addition to their role in bile modification, cholangiocytes also perform several other integral functions. For instance, these cells express Toll-like receptors (TLRs) which allow cholangiocytes to initiate an immune response against pathogens in the biliary lumen. When functioning normally, these cells contribute to biliary integrity, hepatic architecture, and overall hepatic physiology. However, when they become pathological, they are involved in the progression of liver diseases, such as primary biliary cirrhosis and cholangiocarcinoma – the malignancy of the biliary tract. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:86481", "ZFA:0009397" ; oboInOwl:hasExactSynonym "epithelial cell of bile duct" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cholangiocyte" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000488" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000069, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002394 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0005026 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0015106 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0032782 ] ) ] ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000069 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002394 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0015106 ] ) ] . obo:CL_1000489 obo:IAO_0000115 "A reticular cell that is part of the splenic cord." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:86497" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "reticular cell of splenic cord" ; rdfs:subClassOf obo:CL_0000432, obo:CL_2000051, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001266 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000432 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001266 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-white-pulp/v1.2/assets/2d-ftu-spleen-white-pulp.png" . obo:CL_1000490 obo:IAO_0000115 "A mesothelial cell that is part of the peritoneum." ; oboInOwl:hasDbXref "FMA:86736" ; oboInOwl:hasExactSynonym "peritoneal mesothelial cell" ; a owl:Class ; rdfs:label "mesothelial cell of peritoneum" ; rdfs:subClassOf obo:CL_0000077, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002358 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002358 ] ) ] . obo:CL_1000491 obo:IAO_0000115 "A mesothelial cell that is part of the pleura." ; terms:description """Mesothelial cells of the pleura form a significant part of the pleural membrane, a thin, double-layered serous membrane that lines the thoracic cavity and encompasses the lungs. These specialized cells contribute to the pleura's key function of producing a lubricating serous fluid, which reduces friction between the lung's outer surface (visceral pleura) and the inner lining of the thoracic cavity (parietal pleura) during respiration. The cellular structure of mesothelial cells, characterized by microvilli on their surface, aids in the secretion and absorption of the pleural fluid, effectively supporting the smooth expansion and contraction of the lungs. Dysregulation in mesothelial cells can lead to pathologies, including pleural effusion and malignant mesothelioma. Mesothelial cells of the pleura display unique immunologic properties. They act as a first line of defense against infection because they are able to recognize pathogens and respond by secreting various cytokines and chemokines. Additionally, these cells are directly involved in the translocation of immune cells into the pleural cavity during inflammatory response, thereby playing an active role in the immune response within the pleural environment. In the event of pleural injury, these cells are also involved in the mesothelial-mesenchymal transition, a process that allows mesothelial cells to transdifferentiate into myofibroblasts and promote tissue repair. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:86737" ; oboInOwl:hasExactSynonym "pleural mesothelial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "mesothelial cell of pleura" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000491" ; rdfs:subClassOf obo:CL_0000077, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000977 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000977 ] ) ] . obo:CL_1000492 obo:IAO_0000115 "A mesothelial cell that is part of the parietal pleura." ; oboInOwl:hasDbXref "FMA:86738" ; a owl:Class ; rdfs:label "mesothelial cell of parietal pleura" ; rdfs:subClassOf obo:CL_1000491, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002400 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002400 ] ) ] . obo:CL_1000493 obo:IAO_0000115 "A mesothelial cell that is part of the visceral pleura." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Mesothelial cells of visceral pleura are specialized epithelial cells that line the inner layer of the pleura, the membrane that envelops the lungs. Positioned adjacent to the lung tissue, these cells form a protective barrier and contribute to the structure of the visceral pleura. They are characterized by their cuboidal to squamous epithelial shape and the presence of microvilli on their surface, a feature aiding in fluid and solute exchange between the pleura and the lungs. The primary function of mesothelial cells of visceral pleura is to secrete a lubricating serous fluid to facilitate smooth, frictionless lung movement within the thoracic cavity during respiration. This helps in the prevention of trauma or damage stemming from the constant rubbing of the lung tissue against the chest wall, hence playing a pivotal role in maintaining respiratory function. Besides fluid secretion, these cells have an essential role in the transportation of fluids and particles across the pleura, as well as in inflammation, wound healing, and tissue repair processes within the pleura. Mesothelial cells of visceral pleura are notably implicated in the development of pleural diseases such as pleural effusion and pleural mesothelioma, a rare and aggressive form of cancer primarily linked with exposure to asbestos. Alterations, such as hyperplasia or metaplasia, may occur in these mesothelial cells under pathological conditions. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "FMA:86739" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "mesothelial cell of visceral pleura" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000493" ; rdfs:subClassOf obo:CL_1000491, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002401 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002401 ] ) ] . obo:CL_1000494 obo:IAO_0000115 "An epithelial cell that is part of a nephron tubule." ; oboInOwl:hasDbXref "FMA:86785", "KUPO:0001022" ; oboInOwl:hasExactSynonym "kidney tubule epithelial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "This needs to be further defined as a juxtamedullary nephron. Will request the juxtamedullary nephron tubule class from UBERON." ; rdfs:label "nephron tubule epithelial cell" ; rdfs:subClassOf obo:CL_1000449, obo:CL_1000507, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004810 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004810 ] ) ] . obo:CL_1000495 obo:IAO_0000115 "A goblet cell that is part of the small intestine." ; oboInOwl:hasDbXref "FMA:86929" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of small intestine", "goblet cell of small intestine", "small intestinal goblet cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "small intestine goblet cell" ; rdfs:subClassOf obo:CL_0019031, obo:CL_1001598 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001902 ] ) ] . obo:CL_1000497 obo:IAO_0000115 "A cell that is part of a kidney." ; oboInOwl:hasDbXref "KUPO:0001010", "ZFA:0009389" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "kidney cell" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:CL_1000500 obo:IAO_0000115 "A cell that is part of kidney interstitium." ; oboInOwl:hasDbXref "KUPO:0001013", "ZFA:0009390" ; oboInOwl:inSubset cl:cellxgene_subset, cl:kidney_upper_slim ; a owl:Class ; rdfs:label "kidney interstitial cell" ; rdfs:subClassOf obo:CL_1000497, obo:CL_4030031, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005215 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005215 ] ) ] . obo:CL_1000504 obo:IAO_0000115 "A cell that is part of a renal medulla." ; oboInOwl:hasDbXref "KUPO:0001017", "ZFA:0009391" ; a owl:Class ; rdfs:label "kidney medulla cell" ; rdfs:subClassOf obo:CL_1000497, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000362 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000362 ] ) ] . obo:CL_1000505 obo:IAO_0000115 "A cell that is part of a renal pelvis." ; oboInOwl:hasDbXref "KUPO:0001018" ; oboInOwl:inSubset cl:kidney_upper_slim ; a owl:Class ; rdfs:label "kidney pelvis cell" ; rdfs:subClassOf obo:CL_1000497, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001224 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001224 ] ) ] . obo:CL_1000507 obo:IAO_0000115 "A cell that is part of a nephron tubule." ; oboInOwl:hasDbXref "KUPO:0001020" ; oboInOwl:inSubset cl:cellxgene_subset, cl:kidney_upper_slim ; a owl:Class ; rdfs:label "kidney tubule cell" ; rdfs:subClassOf obo:CL_1000497, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001231 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001231 ] ) ] . obo:CL_1000510 obo:IAO_0000115 "Any kidney epithelial cell that is part of some glomerular epithelium." ; oboInOwl:hasDbXref "KUPO:0001023" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "kidney glomerular epithelial cell" ; rdfs:subClassOf obo:CL_1000746, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004188 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002518 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004188 ] ) ] . obo:CL_1000546 obo:IAO_0000115 "An epithelial cell that is part of a renal medulla collecting duct." ; oboInOwl:hasDbXref "KUPO:0001060" ; oboInOwl:inSubset cl:kidney_upper_slim ; a owl:Class ; rdfs:label "kidney medulla collecting duct epithelial cell" ; rdfs:subClassOf obo:CL_1000454, obo:CL_1000504, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005185 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005185 ] ) ] . obo:CL_1000547 obo:IAO_0000115 "An epithelial cell that is part of some inner medullary collecting duct." ; oboInOwl:hasDbXref "KUPO:0001061" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "kidney inner medulla collecting duct epithelial cell" ; rdfs:subClassOf obo:CL_1000546, obo:CL_1000617, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004205 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004205 ] ) ] . obo:CL_1000548 obo:IAO_0000115 "An epithelial cell that is part of an outer medullary collecting duct." ; oboInOwl:hasDbXref "KUPO:0001062" ; a owl:Class ; rdfs:label "kidney outer medulla collecting duct epithelial cell" ; rdfs:subClassOf obo:CL_1000546, obo:CL_1000616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004204 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004204 ] ) ] . obo:CL_1000549 obo:IAO_0000115 "An epithelial cell that is part of a cortical collecting duct." ; oboInOwl:hasDbXref "KUPO:0001063" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "kidney cortex collecting duct epithelial cell" ; rdfs:subClassOf obo:CL_0002584, obo:CL_1000454, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004203 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004203 ] ) ] . obo:CL_1000550 obo:IAO_0000115 "Any kidney cell that is part of some papillary duct." ; oboInOwl:hasDbXref "KUPO:0001064" ; oboInOwl:inSubset cl:kidney_upper_slim ; a owl:Class ; rdfs:label "kidney papillary duct principal epithelial cell" ; rdfs:subClassOf obo:CL_1001225, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005167 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005167 ] ) ] . obo:CL_1000596 obo:IAO_0000115 "Any kidney cell that is part of some juxtamedullary cortex." ; oboInOwl:hasDbXref "KUPO:0001111" ; a owl:Class ; rdfs:label "inner renal cortex cell" ; rdfs:subClassOf obo:CL_0002681, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005271 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005271 ] ) ] . obo:CL_1000597 obo:IAO_0000115 "A cell that is part of a tip of a renal papilla." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001112" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "papillary tips cell" ; rdfs:subClassOf obo:CL_1000505, obo:CL_1000617, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009095 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009095 ] ) ] . obo:CL_1000600 obo:IAO_0000115 "Any cell that is part of some lower urinary tract." ; oboInOwl:hasDbXref "KUPO:0001115" ; a owl:Class ; rdfs:label "lower urinary tract cell" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001556 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001556 ] ) ] . obo:CL_1000601 obo:IAO_0000115 "Any cell that is part of some ureter." ; oboInOwl:hasDbXref "KUPO:0001116" ; a owl:Class ; rdfs:label "ureteral cell" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000056 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000056 ] ) ] . obo:CL_1000606 obo:IAO_0000115 "Any neuron that has its soma located in some kidney." ; oboInOwl:hasDbXref "KUPO:0001015" ; a owl:Class ; rdfs:label "kidney nerve cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_1000500, obo:CL_2000032, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002113 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:CL_1000612 obo:IAO_0000115 "Any renal cortical epithelial cell that is part of some renal corpuscle." ; oboInOwl:hasDbXref "KUPO:0001021" ; oboInOwl:inSubset cl:kidney_upper_slim ; a owl:Class ; rdfs:label "kidney corpuscule cell" ; rdfs:subClassOf obo:CL_0002584, obo:CL_1000449, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001229 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002584 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001229 ] ) ] . obo:CL_1000615 obo:IAO_0000115 "Any kidney tubule cell that is part of some renal cortex tubule." ; oboInOwl:hasDbXref "KUPO:0001024" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "kidney cortex tubule cell" ; rdfs:subClassOf obo:CL_0002584, obo:CL_1000449, obo:CL_1000507, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006853 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000507 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006853 ] ) ] . obo:CL_1000616 obo:IAO_0000115 "Any kidney medulla cell that is part of some outer medulla of kidney." ; oboInOwl:hasDbXref "KUPO:0001025" ; a owl:Class ; rdfs:label "kidney outer medulla cell" ; rdfs:subClassOf obo:CL_1000504, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001293 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000504 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001293 ] ) ] . obo:CL_1000617 obo:IAO_0000115 "Any kidney medulla cell that is part of some inner medulla of kidney." ; oboInOwl:hasDbXref "KUPO:0001026" ; a owl:Class ; rdfs:label "kidney inner medulla cell" ; rdfs:subClassOf obo:CL_1000504, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001294 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000504 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001294 ] ) ] . obo:CL_1000618 obo:IAO_0000115 "Any kidney cortical cell that is part of some juxtaglomerular apparatus." ; oboInOwl:hasDbXref "KUPO:0001028" ; oboInOwl:hasExactSynonym "juxtaglomerulus cell" ; oboInOwl:inSubset cl:kidney_upper_slim ; a owl:Class ; rdfs:label "juxtaglomerular complex cell" ; rdfs:subClassOf obo:CL_0002681, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002303 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002681 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002303 ] ) ] . obo:CL_1000681 obo:IAO_0000115 "A cell that is part of an interstitial compartment of a renal cortex." ; oboInOwl:hasDbXref "KUPO:0001091" ; a owl:Class ; rdfs:label "kidney cortex interstitial cell" ; rdfs:subClassOf obo:CL_0002584, obo:CL_1000500, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005270 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000500 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005270 ] ) ] . obo:CL_1000682 obo:IAO_0000115 "A cell that is part of an interstitum of a renal medulla." ; oboInOwl:hasDbXref "KUPO:0001092" ; a owl:Class ; rdfs:label "kidney medulla interstitial cell" ; rdfs:subClassOf obo:CL_1000500, obo:CL_1000504, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005211 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000500 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005211 ] ) ] . obo:CL_1000691 obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001101" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney interstitial myofibroblast" ; rdfs:subClassOf obo:CL_0000186, obo:CL_1000500 . obo:CL_1000692 obo:IAO_0000115 "A fibroblast that is part of an interstitial compartment of a kidney." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001102" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney interstitial fibroblast" ; rdfs:subClassOf obo:CL_0000057, obo:CL_1000500 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005215 ] ) ] . obo:CL_1000693 oboInOwl:hasDbXref "KUPO:0001103" ; a owl:Class ; rdfs:label "kidney interstitial fibrocyte" ; rdfs:subClassOf obo:CL_0000135, obo:CL_1000500 . obo:CL_1000695 obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001106" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney interstitial alternatively activated macrophage" ; rdfs:subClassOf obo:CL_0000890, obo:CL_1000500 . obo:CL_1000696 oboInOwl:hasDbXref "KUPO:0001107" ; a owl:Class ; rdfs:label "kidney interstitial inflammatory macrophage" ; rdfs:subClassOf obo:CL_0000863, obo:CL_1000500 . obo:CL_1000697 oboInOwl:hasDbXref "KUPO:0001108" ; a owl:Class ; rdfs:label "kidney interstitial suppressor macrophage" ; rdfs:subClassOf obo:CL_0000862, obo:CL_1000500 . obo:CL_1000698 obo:IAO_0000115 "A tissue-resident macrophage that is part of some kidney." ; terms:description """Kidney resident macrophages are a heterogeneous population of immune cell found in the cortex and medullary regions of the kidney as well as within and surround the glomeruli. Their primary role involves maintaining homeostasis and immune surveillance in the kidney microenvironment, defending against ascending urinary infections. Beyond traditional macrophage roles such as phagocytosis and antigen presentation, kidney resident macrophages also contribute significantly to the response to kidney injury including tissue repair and angiogenesis. Under normal physiological conditions, kidney resident macrophages work to maintain the balance of the kidney's microenvironment by removing dead cells, pathogens and cellular debris, to limit inflammation and tissue damage. They are ‘professional’ phagocytes, clearing pathogens and debris by engulfing and digesting these harmful materials. Moreover, they are capable of presenting antigens to other immune cells, which aids in the activation of the adaptive immune response. Kidney resident macrophages show a high degree of plasticity: in response to environmental stimuli they change their morphology and cell surface markers. For example, in response to acute injury, some macrophages adopt a pro-inflammatory phenotype and augment tissue damage; once the injury stimulus is removed, they may change to mediate tissue repair. While kidney macrophages contribute to wound healing, tissue repair and regeneration by producing key growth factors and cytokines that stimulate cell proliferation, collagen production, and blood vessel formation, dysregulation in their activity can also lead to progressive inflammation and fibrosis, common features in chronic kidney disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001109" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "kidney resident macrophage" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000698" ; rdfs:subClassOf obo:CL_0000864, obo:CL_1000500 . obo:CL_1000699 obo:IAO_0000115 "A resident-dendritic cell that is part of a kidney." ; oboInOwl:hasDbXref "KUPO:0001110" ; a owl:Class ; rdfs:label "kidney resident dendritic cell" ; rdfs:subClassOf obo:CL_0001007, obo:CL_1000500 . obo:CL_1000702 obo:IAO_0000115 "Any smooth muscle cell that is part of some kidney pelvis smooth muscle." ; oboInOwl:hasDbXref "KUPO:0001113" ; a owl:Class ; rdfs:label "kidney pelvis smooth muscle cell" ; rdfs:subClassOf obo:CL_0000192, obo:CL_1000505, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004227 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004227 ] ) ] . obo:CL_1000703 obo:IAO_0000115 "Any kidney epithelial cell that is part of some kidney pelvis urothelium." ; oboInOwl:hasDbXref "KUPO:0001114" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "kidney pelvis urothelial cell" ; rdfs:subClassOf obo:CL_0000731, obo:CL_0002518, obo:CL_1000505, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004788 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002518 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004788 ] ) ] . obo:CL_1000706 obo:IAO_0000115 "A urothelial cell that is part of the urothelium of ureter." ; oboInOwl:hasDbXref "KUPO:0001117" ; a owl:Class ; rdfs:label "ureter urothelial cell" ; rdfs:subClassOf obo:CL_0000731, obo:CL_1000601, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001254 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000731 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001254 ] ) ] . obo:CL_1000708 obo:IAO_0000115 "Any ureteral cell that is part of some adventitia of ureter." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001119" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "ureter adventitial cell" ; rdfs:subClassOf obo:CL_0000115, obo:CL_0002503, obo:CL_1000601, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001252 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000601 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001252 ] ) ] . obo:CL_1000714 obo:IAO_0000115 "Any renal principal cell that is part of some cortical collecting duct." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001130" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney cortex collecting duct principal cell" ; rdfs:subClassOf obo:CL_1000549, obo:CL_1001431 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004203 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-cortical-collecting-duct/v1.3/assets/2d-ftu-kidney-cortical-collecting-duct.png", "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" . obo:CL_1000715 obo:IAO_0000115 "Any renal intercalated cell that is part of some cortical collecting duct." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001131" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney cortex collecting duct intercalated cell" ; rdfs:subClassOf obo:CL_1000549, obo:CL_1001432 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005010 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004203 ] ) ] . obo:CL_1000716 obo:IAO_0000115 "Principal cell that is part of some outer medullary collecting duct. It is known in some mammalian species that this cell may express the epithelial sodium channel (ENaC)." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001132" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney outer medulla collecting duct principal cell" ; rdfs:subClassOf obo:CL_1000548, obo:CL_1001431 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004204 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png", "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-outer-medullary-collecting-duct/v1.2/assets/2d-ftu-kidney-outer-medullary-collecting-duct.png" . obo:CL_1000717 obo:IAO_0000115 "Intercalated cell that is part of some outer medullary collecting duct. It is known in some mammalian species that this cell may contribute in the maintenance of acid/base homeostasis." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001133" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney outer medulla collecting duct intercalated cell" ; rdfs:subClassOf obo:CL_1000548, obo:CL_1001432 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005010 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004204 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-outer-medullary-collecting-duct/v1.2/assets/2d-ftu-kidney-outer-medullary-collecting-duct.png" . obo:CL_1000718 obo:IAO_0000115 "Any renal principal cell that is part of some inner medullary collecting duct." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001134" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney inner medulla collecting duct principal cell" ; rdfs:subClassOf obo:CL_1000547, obo:CL_1001431 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004205 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-inner-medullary-collecting-duct/v1.2/assets/2d-ftu-kidney-inner-medullary-collecting-duct.png", "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" . obo:CL_1000719 obo:IAO_0000115 "Any renal intercalated cell that is part of some inner medullary collecting duct." ; oboInOwl:hasDbXref "KUPO:0001135" ; a owl:Class ; rdfs:label "kidney inner medulla collecting duct intercalated cell" ; rdfs:subClassOf obo:CL_1000547, obo:CL_1001432 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005010 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004205 ] ) ] . obo:CL_1000720 obo:IAO_0000115 "Any renal intercalated cell that is part of some papillary duct." ; oboInOwl:hasDbXref "KUPO:0001136" ; a owl:Class ; rdfs:label "kidney papillary duct intercalated cell" ; rdfs:subClassOf obo:CL_1000550, obo:CL_1001432 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005010 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005167 ] ) ] . obo:CL_1000721 obo:IAO_0000115 "Any renal principal cell that is part of some papillary duct." ; oboInOwl:hasDbXref "KUPO:0001137" ; a owl:Class ; rdfs:label "kidney papillary duct principal cell" ; rdfs:subClassOf obo:CL_1000550, obo:CL_1001431 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005167 ] ) ] . obo:CL_1000742 obo:IAO_0000115 "A mesangial cell located among the glomerular capillaries in a renal corpuscle." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001032" ; oboInOwl:hasExactSynonym "intraglomerular mesangial cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Like smooth muscle, a glomerular mesangial cell is contractile and possesses the filaments actin and myosin. The contractile mechanism is also similar to that of smooth muscle, with Ca2+/calmodulin-activated myosin light-chain kinase instigating myosin-actin cross-bridge cycling. Mesangial cell phagocytosis of apoptotic neutrophils involves a novel CD36-independent, alpha(v)beta3/TSP-mediated mechanism that is uncoupled from chemokine secretion, emphasizing the injury-limiting potential of mesangial cell phagocytosis of apoptotic cells." ; rdfs:label "glomerular mesangial cell" ; rdfs:subClassOf obo:CL_0000234, obo:CL_0000650, obo:CL_1000746, obo:CL_1001318, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002320 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070252 ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" . obo:CL_1000746 obo:IAO_0000115 "Any kidney corpuscule cell that is part of some renal glomerulus." ; oboInOwl:hasDbXref "KUPO:0001036" ; a owl:Class ; rdfs:label "glomerular cell" ; rdfs:subClassOf obo:CL_1000612, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000074 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000612 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000074 ] ) ] . obo:CL_1000768 obo:IAO_0000115 "Any nephron tubule epithelial cell that is part of some renal connecting tubule." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Kidney connecting tubule epithelial cells are found in collecting duct system of the kidney, specifically in at the interconnection segment between the nephron and the collecting ducts. The epithelial cells lining the connecting tubule are crucial for the journey of filtrate before it empties into urine-collecting ducts and therefore play a critical role in maintaining the body’s fluid and electrolyte balance. One of the principal functions of connecting tubule epithelial cells involves the selective reabsorption and secretion of various solutes. This reabsorption process includes critical regulatory electrolytes such as sodium ions (Na+), chloride ions (Cl-), and bicarbonate ions (HCO3-), thus playing a role in the regulation of the acid-base homeostasis. Their function also involves the secretion of potassium ions (K+) into the renal tubular fluid. The connecting tubule epithelial cells are primarily intercalated cells, which can be categorized into two types according to their specific functions: type A intercalated cells, which secrete acid, and the type B intercalated cells, which secrete base (bicarbonate) and reabsorb chloride. By regulating the concentrations of these ions, as well as reabsorption of water, connecting tubule epithelial cells contribute substantively to maintaining the body's electrolyte levels, pH balance, and overall homeostasis. In addition to intercalating cells, the collecting duct system also has principal cells, which are characterized by the expression of the water channel AQP2. AQP2-expressing cells have also been identified in connecting tubules, but there is some controversy whether these represent a unique cell type as there are some morphologic differences compared with principal cells. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001058" ; oboInOwl:inSubset cl:cellxgene_subset, cl:kidney_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney connecting tubule epithelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000768" ; rdfs:subClassOf obo:CL_1000494, obo:CL_1000615, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005097 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000494 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005097 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" . obo:CL_1000803 obo:IAO_0000115 "A cell that is part of an interstitial compartment of an inner renal medulla." ; oboInOwl:hasDbXref "KUPO:0001093" ; a owl:Class ; rdfs:label "kidney inner medulla interstitial cell" ; rdfs:subClassOf obo:CL_1000617, obo:CL_1000682, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005214 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000682 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005214 ] ) ] . obo:CL_1000804 obo:IAO_0000115 "A kidney cell that is part of an interstitial compartment of an outer renal medulla." ; oboInOwl:hasDbXref "KUPO:0001094" ; a owl:Class ; rdfs:label "kidney outer medulla interstitial cell" ; rdfs:subClassOf obo:CL_1000616, obo:CL_1000682, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005213 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000682 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005213 ] ) ] . obo:CL_1000838 obo:IAO_0000115 "Any epithelial cell of proximal tubule that is part of some proximal convoluted tubule and has part some brush border." ; terms:description """Kidney proximal convoluted tubule epithelial cells line the most voluminous part of the kidney's nephron, the proximal convoluted tubule, located in the cortex of the kidney. These cells are primarily involved in reabsorption and secretion processes, key functions that facilitate homeostasis within the body. Proximal convoluted tubule epithelial cells extensively function in the reabsorption process to a greater degree than their counterparts in the proximal straight tubule. Approximately two-thirds of filtrated sodium and water, nearly all nutrient sugars and amino acids, and a significant portion of bicarbonates pass through the proximal convoluted tubule, are effectively absorbed by the epithelial cells, and reenter the bodily circulation. By absorbing bicarbonates and secreting protons into the tubular fluid, proximal convoluted tubule epithelial cells also contribute to the pH regulation in the body . In addition to reabsorption, proximal convoluted tubule epithelial cells also play a critical role in the excretion of waste metabolites and xenobiotics. These cells possess a range of transporters that secrete metabolic end products and certain drugs, hence aiding in their elimination. This function underlines their importance for body detoxification. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001045" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "kidney proximal convoluted tubule epithelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000838" ; rdfs:subClassOf obo:CL_0002307, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001287 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002306 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001287 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005903 ] ) ] . obo:CL_1000839 obo:IAO_0000115 "Any epithelial cell of proximal tubule that is part of some proximal straight tubule." ; terms:description """Kidney proximal straight tubule epithelial cells line the straight portion of the proximal tubule of the nephron, extending from the cortical medullary ray into the outer stripe of the outer medulla. They are characterized by a brush border of dense microvilli on their apical surface, enhancing the cell's surface area and aiding reabsorption, though reabsorption occurs more heavily in the proximal convoluted tubule preceding the straight portion of the tubule. The primary function of the kidney proximal straight tubule epithelial cells is to reabsorb the filtrate that the kidney produces, which includes glucose, sodium, and water. The reabsorption occurs through both passive and active transport methods. These cells exhibit enzyme-rich microvilli that also absorb small proteins and peptides. Consequently, they are involved in the regulation of plasma levels of various substances, including glucose, amino acids, and electrolytes, and maintain the body's pH homeostasis by secreting H+ ions into the urine and absorbing bicarbonate ions. These cells are also reported to be involved in drug metabolism. Many drugs are filtered from the blood by the kidneys and subsequently reabsorbed by the kidney proximal tubule epithelial cells back into the bloodstream. Furthermore, these cells play a significant role in the progression of kidney diseases. For example, in diabetic nephropathy and acute kidney injury, kidney proximal straight tubule epithelial cells can undergo cellular changes and result in malfunctions such as reduced reabsorption and increased excretion. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001046" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "kidney proximal straight tubule epithelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000839" ; rdfs:subClassOf obo:CL_0002306, obo:CL_1000616, obo:CL_1001021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001290 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002306 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001290 ] ) ] . obo:CL_1000849 obo:IAO_0000115 "Any epithelial cell of distal tubule that is part of some distal convoluted tubule." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Kidney distal convoluted tubule epithelial cells, often referred to simply as distal convoluted tubule (DCT) cells, constitute a significant portion of the nephron -- the functional building unit of the kidney involved in filtration and reabsorption of substances from blood. The DCT epithelial cells form lining of the distal convoluted tubule, a segment of the nephron located after the loop of Henle and before the collecting tubule. These cells are characterized by unique morphological features such as small size, low height and fewer microvilli compared to proximal convoluted tubule epithelial cells. These cells perform a host of vital functions contributing to the regulation of extracellular fluid volume and electrolyte balance, blood pressure and pH. While the DCT is less prominent in water and sodium reabsorption compared to the proximal tubule and the loop of Henle, it plays a crucial role in fine-tuning the process. DCT epithelial cells are responsible for the final adjustments of sodium, potassium and calcium reabsorption, thereby affecting overall fluid and electrolyte balance, blood pressure regulation and bone health. The reabsorption process is regulated by hormones including aldosterone and parathyroid hormone. The distal convoluted tubule (DCT) also plays a significant role in acid-base homeostasis by secreting protons (H+) into the tubular fluid and reabsorbing bicarbonate ions (HCO3-), thus regulating the pH of the blood. The ability of DCT cells to adjust urine concentration plays a part in maintaining the body’s pH balance and preventing conditions like acidosis or alkalosis. In summary, kidney distal convoluted tubule epithelial cells perform functions that are crucial to maintaining body's homeostasis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001056" ; oboInOwl:inSubset cl:cellxgene_subset, cl:kidney_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney distal convoluted tubule epithelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000849" ; rdfs:subClassOf obo:CL_0002305, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001292 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002305 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001292 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" . obo:CL_1000850 obo:IAO_0000115 "An epithelial cell that is part of the macula densa, characterized by a tightly packed arrangement, apically positioned nuclei, and prominent primary cilia, creating a distinctive 'dense spot' appearance under microscopy. It is involved in regulating renal blood flow, glomerular filtration rate, and renin release." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Macula densa epithelial cells, as part of the complex nephron structure, play a crucial role in kidney function. These cells, which make up the macula densa, help regulate blood pressure and the filtration rate of the glomerulus by sensing sodium chloride amounts in the kidney tubules. Found where the thick ascending limb of the Loop of Henle touches the afferent arteriole, macula densa epithelial cells are positioned in an optimal location to monitor and respond to changes in the filtrate composition. These cells maintain intraglomerular homeostasis. When the sodium chloride concentration is high, macula densa cells respond by secreting adenosine and vasoconstricting the afferent arteriole to decrease the glomerular filtration rate. Conversely, if the sodium chloride concentration in the filtrate is low, the production and release of nitric oxide cause vasodilation to enhance the glomerular filtration rate. Macula densa epithelial cells also have a role in tubuloglomerular feedback mechanisms, an essential autoregulatory renal response. They send feedback to the glomerular mesangial cells, allowing constriction or relaxation of the afferent arteriole as needed depending on the content of the filtrate. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001057" ; oboInOwl:hasExactSynonym "macula densa cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "macula densa epithelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000850" ; rdfs:subClassOf obo:CL_0000067, obo:CL_0002305, obo:CL_1000618, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002335 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0097730 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0003093 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_1900133 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002335 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png", "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" . obo:CL_1000854 obo:IAO_0000115 "A blood vessel cell that is part of a kidney." ; oboInOwl:hasDbXref "KUPO:0001014" ; a owl:Class ; rdfs:label "kidney blood vessel cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_1000504, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003517 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0008015 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003517 ] ) ] . obo:CL_1000891 obo:IAO_0000115 "Any kidney blood vessel cell that is part of some kidney arterial blood vessel." ; oboInOwl:hasDbXref "KUPO:0001029" ; oboInOwl:inSubset cl:cellxgene_subset, cl:kidney_upper_slim ; a owl:Class ; rdfs:label "kidney arterial blood vessel cell" ; rdfs:subClassOf obo:CL_1000854, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003644 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000854 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003644 ] ) ] . obo:CL_1000892 obo:IAO_0000115 "An endothelial cell that is part of the capillary of the kidney." ; oboInOwl:hasDbXref "KUPO:0001030" ; oboInOwl:inSubset cl:cellxgene_subset, cl:kidney_upper_slim ; a owl:Class ; rdfs:label "kidney capillary endothelial cell" ; rdfs:subClassOf obo:CL_0002144, obo:CL_1000854, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003527 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003527 ] ) ] . obo:CL_1000893 obo:IAO_0000115 "Any kidney blood vessel cell that is part of some renal vein." ; oboInOwl:hasDbXref "KUPO:0001031" ; oboInOwl:inSubset cl:kidney_upper_slim ; a owl:Class ; rdfs:label "kidney venous blood vessel cell" ; rdfs:subClassOf obo:CL_1000854, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001140 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000854 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001140 ] ) ] . obo:CL_1000897 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_1000452 ; a owl:Class ; owl:deprecated true . obo:CL_1000909 obo:IAO_0000115 "Any nephron tubule epithelial cell that is part of some loop of Henle." ; oboInOwl:hasDbXref "KUPO:0001047" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "kidney loop of Henle epithelial cell" ; rdfs:subClassOf obo:CL_1000494, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001288 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000494 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001288 ] ) ] . obo:CL_1000979 obo:IAO_0000115 "Any smooth muscle cell that is part of some muscular coat of ureter." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001118" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "ureter smooth muscle cell" ; rdfs:subClassOf obo:CL_0000192, obo:CL_1000601, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006855 ] ; owl:equivalentClass _:genid15717 . obo:CL_1001005 obo:IAO_0000115 "An endothelial cell that is part of the glomerular capillary of the kidney." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """The glomerular capillary endothelial cell comprises an intrinsic component of the glomerulus in the kidney. Glomeruli contain a network of capillaries where the first step of blood filtration takes place, with glomerular capillary endothelial cells acting as an integral part of this process. Unlike regular endothelial cells that line the vasculature, unique fenestrations (openings) characterize these cells, allowing for enhanced permeability and filtration efficacy. Together with the glomerular basement membrane and podocytes, the glomerular endothelial cells form the glomerular filtration barrier, which is responsible for blood filtration and therefore critical for removal of waste products, such as urea and creatinine, and excess substances, such as glucose and ions, from the bloodstream. The glomerular capillary endothelial cells' fenestrations permit the free flow of a variety of particles, barring larger, negatively charged proteins like serum albumin, enabling the formation of an ultrafiltrate. This ultrafiltrate is the primitive form of urine, which then passes through the proximal tubule for further processing and ultimately helps maintain systemic fluid and electrolyte balance. Moreover, the glomerular capillary endothelial cells are also believed to play a crucial role in renal pathologies. Any compromise to their structural integrity or functional performance can lead to kidney diseases, including but not limited to, diabetic nephropathy and glomerulonephritis. For instance, in diabetes, persistent hyperglycemia can injure these cells, leading to a compromised glomerular filtration barrier and proteinuria, indicating the loss of proteins in the urine. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001037" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "glomerular capillary endothelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001005" ; rdfs:subClassOf obo:CL_0002188, obo:CL_1000892, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004294 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004294 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" . obo:CL_1001006 obo:IAO_0000115 "An endothelial cell which is part of the afferent arteriole in the kidney. This cell is responsible for maintaining renal blood flow and glomerular filtration rate." ; terms:description """Kidney afferent arteriole cells are specialized cell types found in the renal vasculature, specifically in the afferent arterioles which help in maintaining the renal blood flow and glomerular filtration rate. They are essential for the proper functioning of the kidneys, contributing to the regulation of blood pressure and fluid balance within the organism. Located before the glomerulus, a tiny, intricate network of capillaries within the nephron, these cells help control the expansion or contraction of the arteriole, thus regulating the pressure and flow of blood into the glomerulus. Functionally, kidney afferent arteriole cells are largely involved in responding to changes in blood volume and systemic blood pressure. They achieve this by modulating the diameter of the afferent arteriole through a process known as autoregulation. Autoregulation involves two primary mechanisms: the myogenic response and the tubuloglomerular feedback. The myogenic response is essentially the intrinsic ability of the vascular smooth muscle to respond to pressure changes, while the tubuloglomerular feedback is the process where the macula densa cells located near the glomerulus respond to changes in fluid delivery rates in the tubules, sending signals to afferent arterioles to constrict or dilate accordingly. These cells also have significant interaction with renin-containing juxtaglomerular cells, which are located in the wall of afferent arterioles. Juxtaglomerular cells secrete the enzyme renin in response to low blood pressure or sympathetic nerve activity, initiating the renin-angiotensin-aldosterone system cascade that ultimately helps retain sodium and water to increase blood volume and pressure. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001038" ; a owl:Class ; rdfs:label "kidney afferent arteriole cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001006" ; rdfs:subClassOf obo:CL_0002681, obo:CL_1000891, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004639 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004639 ] ) ] . obo:CL_1001009 obo:IAO_0000115 "Any kidney arterial blood vessel cell that is part of some renal efferent arteriole." ; terms:description """Kidney efferent arteriole cells are highly adaptable vascular cells that make up the efferent arterioles in the kidney. These units are integral components of the renal microcirculation system, conducting blood away from the glomeruli after filtration occurs. Efferent arterioles directly affect glomerular hydrostatic pressure and, subsequently, the rate of glomerular filtration. They are the downstream channels that ensure the effective transportation of blood to the peritubular capillaries and vasa recta, critical for maintaining fluid balance and electrolyte homeostasis. Kidney efferent arteriole cells are exceptional in their ability to perform autoregulation—a critical dynamic control of intrarenal blood flow ensuring stable glomerular filtration rates. This is primarily achieved via myogenic and tubuloglomerular feedback mechanisms, where the cells respond to changes in pressure and the concentration of sodium chloride in the tubular fluid, and constrict or dilate depending on the detected changes. Cells associated with the efferent arteriole also respond to several systemic influences. Through complex intracellular signaling pathways, they respond to fluctuations in hormones (like angiotensin II and endothelin) and several other mediators such as nitric oxide and prostaglandins. Their adaptive capability helps maintain homeostasis and ensures the entire system's optimal performance under various physiological conditions. Dysfunctions in kidney efferent arteriole cells can lead to severe pathologies like hypertension and chronic kidney disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001041" ; a owl:Class ; rdfs:label "kidney efferent arteriole cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001009" ; rdfs:subClassOf obo:CL_0002681, obo:CL_1000891, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004640 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004640 ] ) ] . obo:CL_1001016 obo:IAO_0000115 "Any kidney loop of Henle epithelial cell that is part of some ascending limb of loop of Henle." ; oboInOwl:hasDbXref "KUPO:0001048" ; oboInOwl:inSubset cl:cellxgene_subset, cl:kidney_upper_slim ; a owl:Class ; rdfs:label "kidney loop of Henle ascending limb epithelial cell" ; rdfs:subClassOf obo:CL_0002305, obo:CL_1000909, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005164 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000909 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005164 ] ) ] . obo:CL_1001021 obo:IAO_0000115 "Any kidney loop of Henle epithelial cell that is part of some descending limb of loop of Henle." ; terms:description """The kidney loop of Henle descending limb epithelial cells are highly specialized cells that play a crucial role in maintaining the body's salt and water balance. These cells line the descending limb of the loop of Henle, which is a portion of the renal tubule located in the kidneys, an organ responsible for filtering waste products, ions and extra water from the blood and converting them into urine. However, the descending limb epithelial cells are specifically involved in the countercurrent multiplication system, a mechanism to concentrate urine that involves both active and passive transport processes. These cells are notably permeable to water but relatively impermeable to solutes, a characteristic that dramatically influences the osmotic gradient in the renal medulla. As filtrate initially descends down the loop of Henle, water gets drawn out due to the increasing osmotic gradient, thereby concentrating the filtrate. Additionally, these epithelial cells are exceptionally thin walled, allowing water to freely diffuse across the membrane. Furthermore, the kidney loop of Henle descending limb epithelial cells are inextricably linked to the functioning of numerous diuretic drugs, which work by blocking the reabsorption of water and certain electrolytes in the kidneys, leading to increased urine production to rid the body of excess fluids. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001053" ; oboInOwl:inSubset cl:cellxgene_subset, cl:kidney_upper_slim ; a owl:Class ; rdfs:label "kidney loop of Henle descending limb epithelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001021" ; rdfs:subClassOf obo:CL_1000909, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001289 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000909 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001289 ] ) ] . obo:CL_1001033 obo:IAO_0000115 "An endothelial cell that is part of the peritubular capillary of the kidney. This cell is highly fenestrated and plays a vital role in the kidney's filtration process, enabling the exchange of materials between the blood and the renal tubules." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001065" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Peritubular capillary endothelial cells feature fenestrations measuring 60-70 nm in diameter, each traversed by a thin diaphragm." ; rdfs:label "peritubular capillary endothelial cell" ; rdfs:subClassOf obo:CL_0000666, obo:CL_1000892, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012441 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012441 ] ) ] . obo:CL_1001036 obo:IAO_0000115 "A cell that is part of a vasa recta." ; oboInOwl:hasDbXref "KUPO:0001068" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "vasa recta cell" ; rdfs:subClassOf obo:CL_1000504, obo:CL_2000008, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004726 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004726 ] ) ] . obo:CL_1001045 obo:IAO_0000115 "Any kidney arterial blood vessel cell that is part of some renal cortex artery." ; oboInOwl:hasDbXref "KUPO:0001077" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "kidney cortex artery cell" ; rdfs:subClassOf obo:CL_0002681, obo:CL_1000891, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005268 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005268 ] ) ] . obo:CL_1001052 obo:IAO_0000115 "Any kidney venous blood vessel cell that is part of some renal cortex vein." ; oboInOwl:hasDbXref "KUPO:0001084" ; a owl:Class ; rdfs:label "kidney cortex vein cell" ; rdfs:subClassOf obo:CL_0002681, obo:CL_1000893, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005269 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000893 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005269 ] ) ] . obo:CL_1001064 oboInOwl:hasDbXref "KUPO:0001096" ; a owl:Class ; rdfs:comment "Note that the source of this term is KUPO:0001096 (artery smooth muscle cell), which we believe actually denotes the kidney specific structure." ; rdfs:label "kidney artery smooth muscle cell" ; rdfs:subClassOf obo:CL_0019018, obo:CL_1000891 . obo:CL_1001066 oboInOwl:hasDbXref "KUPO:0001098" ; a owl:Class ; rdfs:comment "Note that the source of this term is KUPO:0001098 (arteriole smooth muscle cell), which we believe actually denotes the kidney specific structure." ; rdfs:label "kidney arteriole smooth muscle cell" ; rdfs:subClassOf obo:CL_0019018, obo:CL_1000891 . obo:CL_1001068 oboInOwl:hasDbXref "KUPO:0001100" ; a owl:Class ; rdfs:comment "Note that the source of this term is KUPO:0001068 (venous system smooth muscle cell), which we believe actually denotes the kidney specific structure." ; rdfs:label "kidney venous system smooth muscle cell" ; rdfs:subClassOf obo:CL_0019018, obo:CL_1000893 . obo:CL_1001096 obo:IAO_0000115 "An endothelial cell that lines the interior surface of the afferent arteriole and maintains vascular tone. This cell responds to changing ion concentrations and blood pressure by releasing vasoactive substances, in order to regulate blood flow into the glomeruli, which is essential for glomerular filtration." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Kidney afferent arteriole endothelial cells are a specialized type of cell located within the kidneys, forming the inner lining of the afferent arterioles, which are responsible for delivering blood to the glomeruli - capillary networks responsible for filtration - from where the process of urine formation begins in the nephrons. The endothelial cells in the kidney afferent arterioles have a key function in regulating the blood flow and filtration. They have autocrine and paracrine signaling capabilities, meaning they can signal to themselves and other nearby cells. They produce nitric oxide, prostacyclin, and endothelin, which are powerful vasodilators and vasoconstrictors that regulate renal blood flow. These cells also engage in the mitigation of kidney injury and inflammation by promoting repair and regeneration, demonstrating the multifaceted roles these cells play in maintaining renal health. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001039" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney afferent arteriole endothelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001096" ; rdfs:subClassOf obo:CL_1000412, obo:CL_1001006 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004639 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" . obo:CL_1001097 obo:IAO_0000115 "A smooth muscle cell found in the wall of the afferent arteriole. This cell contracts and relaxes in response to changes in blood pressure, a process known as a myogenic response, to alter artery diameter and regulate blood flow into the glomeruli." ; oboInOwl:hasDbXref "KUPO:0001040" ; a owl:Class ; rdfs:label "kidney afferent arteriole smooth muscle cell" ; rdfs:subClassOf obo:CL_0008035, obo:CL_1001006, obo:CL_1001066 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004639 ] ) ] . obo:CL_1001099 obo:IAO_0000115 "Any endothelial cell that is part of some renal efferent arteriole." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Kidney efferent arteriole endothelial cells constitute a vital component of the kidney's microvascular system. They are unique endothelial cells found lining the walls of efferent arterioles, which transport blood away from the glomeruli in the kidney. The primary responsibilities of the kidney efferent arteriole endothelial cells involve controling renal blood flow, regulating glomerular filtration rate (GFR), and managing perfusion pressure. They do this by contracting and relaxing, effectively narrowing and widening the arteriole's lumen thereby controling the volume and rate of blood flow to the peritubular capillaries and creating the pressure gradient necessary for filtration in the glomerulus. Furthermore, kidney efferent arteriole endothelial cells show a high degree of plasticity in response to pathophysiological stimuli and can undergo structural and functional changes based on local needs. In conditions like hypertension and diabetes, these cells can experience hypertrophy and endothelial dysfunction, contributing to the progression of renal disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001042" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney efferent arteriole endothelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001099" ; rdfs:subClassOf obo:CL_1000412, obo:CL_1001009 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004640 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" . obo:CL_1001100 obo:IAO_0000115 "Any smooth muscle cell that is part of some renal efferent arteriole." ; oboInOwl:hasDbXref "KUPO:0001043" ; a owl:Class ; rdfs:label "kidney efferent arteriole smooth muscle cell" ; rdfs:subClassOf obo:CL_0008035, obo:CL_1001009, obo:CL_1001066 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004640 ] ) ] . obo:CL_1001106 obo:IAO_0000115 "An epithelial cell that is part of some loop of Henle thick ascending limb. It is known in some mammalian species that this cell may express the Na+-K+-2Cl− cotransporter (NKCC2) apically." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001049" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney loop of Henle thick ascending limb epithelial cell" ; rdfs:subClassOf obo:CL_1000504, obo:CL_1001016, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001291 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001016 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001291 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png", "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-thick-ascending-loop-of-henle/v1.2/assets/2d-ftu-kidney-thick-ascending-loop-of-henle.png" . obo:CL_1001107 obo:IAO_0000115 "An epithelial cell that is part of some loop of Henle thin ascending limb." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001050" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney loop of Henle thin ascending limb epithelial cell" ; rdfs:subClassOf obo:CL_1000617, obo:CL_1001016, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004193 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001016 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004193 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-ascending-thin-loop-of-henle/v1.2/assets/2d-ftu-kidney-ascending-thin-loop-of-henle.png", "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" . obo:CL_1001108 obo:IAO_0000115 "An epithelial cell that is part of some loop of Henle thick ascending limb segment located in the renal medulla." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001051" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney loop of Henle medullary thick ascending limb epithelial cell" ; rdfs:subClassOf obo:CL_1000616, obo:CL_1001106, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006376 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001016 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006376 ] ) ] . obo:CL_1001109 obo:IAO_0000115 "An epithelial cell that is part of some loop of Henle thick ascending limb segment located in the renal cortex." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001052" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney loop of Henle cortical thick ascending limb epithelial cell" ; rdfs:subClassOf obo:CL_1001106, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006854 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001016 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006854 ] ) ] . obo:CL_1001111 obo:IAO_0000115 "An epithelial cell that is part of some loop of Henle thin descending limb." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001054" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney loop of Henle thin descending limb epithelial cell" ; rdfs:subClassOf obo:CL_1000453, obo:CL_1000616, obo:CL_1001021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005096 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005096 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-descending-thin-loop-of-henle/v1.1/assets/2d-ftu-kidney-descending-thin-loop-of-henle.png", "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" . obo:CL_1001123 obo:IAO_0000115 "An endothelial cell that is part of the peritubular capillary of the outer renal medulla." ; oboInOwl:hasDbXref "KUPO:0001066" ; a owl:Class ; rdfs:label "kidney outer medulla peritubular capillary cell" ; rdfs:subClassOf obo:CL_1000616, obo:CL_1001033, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006341 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001033 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006341 ] ) ] . obo:CL_1001124 obo:IAO_0000115 "An endothelial cell that is part of the peritubular capillary of the renal cortex." ; oboInOwl:hasDbXref "KUPO:0001067" ; a owl:Class ; rdfs:label "kidney cortex peritubular capillary cell" ; rdfs:subClassOf obo:CL_0002681, obo:CL_1001033, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006851 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001033 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006851 ] ) ] . obo:CL_1001126 obo:IAO_0000115 "Any vasa recta cell that is part of some inner renal medulla vasa recta." ; oboInOwl:hasDbXref "KUPO:0001069" ; a owl:Class ; rdfs:label "inner renal medulla vasa recta cell" ; rdfs:subClassOf obo:CL_1000617, obo:CL_1001036, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004776 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001036 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004776 ] ) ] . obo:CL_1001127 obo:IAO_0000115 "Any vasa recta cell that is part of some outer renal medulla vasa recta." ; oboInOwl:hasDbXref "KUPO:0001070" ; a owl:Class ; rdfs:label "outer renal medulla vasa recta cell" ; rdfs:subClassOf obo:CL_1000616, obo:CL_1001036, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004775 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001036 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004775 ] ) ] . obo:CL_1001131 obo:IAO_0000115 "A cell that is part of some vasa recta ascending limb." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """The vasa recta ascending limb cells are specialized epithelial cells that are part of the vasa recta in the kidney, a crucial component of the renal medulla that functions as a counter-current exchanger to maintain the concentration gradient required for water reabsorption. These particular cells are located in the ascending limb of the vasa recta, which takes blood flow from the medulla back to the cortex. The primary function of vasa recta ascending limb cells is to preserve the renal medulla's hypertonicity, necessary for the kidney's urine concentration mechanism. Unlike the vasa recta descending limb cells, the venous-like epithelial cells of the ascending vasa recta are highly fenestrated and lack pericyte coverage, which facilitates water reuptake. As the blood flows through the ascending limb, it loses solutes and gains water, which is driven by the high solute concentration in the surrounding interstitium. This process acts in concert with cellular action in the descending limb and contributions from the so-called Loop of Henle, which helps with water and sodium chloride retrieval from the urine. In the context of normal physiological processes, the function of the vasa recta ascending limb cells is essential in maintaining the body's overall fluid balance, electrolyte concentration, and systemic blood pressure. Any dysfunction in these cells may lead to impaired urine concentration or dilution capability of the kidney, potentially resulting in conditions like diabetes insipidus or hyponatremia. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001074" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "It is known in some mammalian species that this cell may express PV-1, a component of the fenestral diaphragm." ; rdfs:label "vasa recta ascending limb cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001131" ; rdfs:subClassOf obo:CL_1001036, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009091 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001036 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009091 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-ascending-thin-loop-of-henle/v1.2/assets/2d-ftu-kidney-ascending-thin-loop-of-henle.png" . obo:CL_1001135 obo:IAO_0000115 "Any kidney cortex artery cell that is part of some kidney arcuate artery." ; oboInOwl:hasDbXref "KUPO:0001078" ; a owl:Class ; rdfs:label "arcuate artery cell" ; rdfs:subClassOf obo:CL_1001045, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001552 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001045 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001552 ] ) ] . obo:CL_1001138 obo:IAO_0000115 "Any kidney cortex artery cell that is part of some interlobular artery." ; oboInOwl:hasDbXref "KUPO:0001081" ; a owl:Class ; rdfs:label "interlobular artery cell" ; rdfs:subClassOf obo:CL_1001045, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004723 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001045 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004723 ] ) ] . obo:CL_1001142 obo:IAO_0000115 "Any kidney cortex vein cell that is part of some kidney arcuate vein." ; oboInOwl:hasDbXref "KUPO:0001085" ; a owl:Class ; rdfs:label "arcuate vein cell" ; rdfs:subClassOf obo:CL_1001052, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004719 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001052 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004719 ] ) ] . obo:CL_1001145 obo:IAO_0000115 "Any kidney cortex vein cell that is part of some renal interlobular vein." ; oboInOwl:hasDbXref "KUPO:0001088" ; a owl:Class ; rdfs:label "interlobular vein cell" ; rdfs:subClassOf obo:CL_1001052, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005168 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001052 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005168 ] ) ] . obo:CL_1001209 obo:IAO_0000115 "Any vasa recta ascending limb cell that is part of some inner medulla ascending vasa recta." ; oboInOwl:hasDbXref "KUPO:0001075" ; a owl:Class ; rdfs:label "inner medulla vasa recta ascending limb cell" ; rdfs:subClassOf obo:CL_1001126, obo:CL_1001131, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009092 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001131 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009092 ] ) ] . obo:CL_1001210 obo:IAO_0000115 "Any vasa recta ascending limb cell that is part of some outer medulla ascending vasa recta." ; oboInOwl:hasDbXref "KUPO:0001076" ; a owl:Class ; rdfs:label "outer medulla vasa recta ascending limb cell" ; rdfs:subClassOf obo:CL_1001127, obo:CL_1001131, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009093 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001131 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009093 ] ) ] . obo:CL_1001213 obo:IAO_0000115 "Any endothelial cell that is part of some kidney arcuate artery." ; oboInOwl:hasDbXref "KUPO:0001079" ; a owl:Class ; rdfs:label "arcuate artery endothelial cell" ; rdfs:subClassOf obo:CL_1000413, obo:CL_1001135 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001552 ] ) ] . obo:CL_1001214 obo:IAO_0000115 "Any smooth muscle cell that is part of some kidney arcuate artery." ; oboInOwl:hasDbXref "KUPO:0001080" ; a owl:Class ; rdfs:label "arcuate artery smooth muscle cell" ; rdfs:subClassOf obo:CL_1001064, obo:CL_1001135 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001552 ] ) ] . obo:CL_1001216 obo:IAO_0000115 "Any endothelial cell that is part of some interlobular artery." ; oboInOwl:hasDbXref "KUPO:0001082" ; a owl:Class ; rdfs:label "interlobulary artery endothelial cell" ; rdfs:subClassOf obo:CL_1000413, obo:CL_1001138 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004723 ] ) ] . obo:CL_1001217 obo:IAO_0000115 "Any smooth muscle cell that is part of some interlobular artery." ; oboInOwl:hasDbXref "KUPO:0001083" ; a owl:Class ; rdfs:label "interlobulary artery smooth muscle cell" ; rdfs:subClassOf obo:CL_1001064, obo:CL_1001138 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004723 ] ) ] . obo:CL_1001220 obo:IAO_0000115 "Any endothelial cell that is part of some kidney arcuate vein." ; oboInOwl:hasDbXref "KUPO:0001086" ; a owl:Class ; rdfs:label "arcuate vein endothelial cell" ; rdfs:subClassOf obo:CL_0002543, obo:CL_1001142 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004719 ] ) ] . obo:CL_1001221 obo:IAO_0000115 "Any smooth muscle cell that is part of some kidney arcuate vein." ; oboInOwl:hasDbXref "KUPO:0001087" ; a owl:Class ; rdfs:label "arcuate vein smooth muscle cell" ; rdfs:subClassOf obo:CL_1001068, obo:CL_1001142 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004719 ] ) ] . obo:CL_1001223 obo:IAO_0000115 "Any endothelial cell that is part of some renal interlobular vein." ; oboInOwl:hasDbXref "KUPO:0001089" ; a owl:Class ; rdfs:label "interlobulary vein endothelial cell" ; rdfs:subClassOf obo:CL_0002543, obo:CL_1001145 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005168 ] ) ] . obo:CL_1001224 obo:IAO_0000115 "Any smooth muscle cell that is part of some renal interlobular vein." ; oboInOwl:hasDbXref "KUPO:0001090" ; a owl:Class ; rdfs:label "interlobulary vein smooth muscle cell" ; rdfs:subClassOf obo:CL_1001068, obo:CL_1001145 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005168 ] ) ] . obo:CL_1001225 obo:IAO_0000115 "A cell that is part of a collecting duct of renal tubule." ; oboInOwl:hasDbXref "KUPO:0001012", "Wikipedia:Kidney_collecting_duct_cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "kidney collecting duct cell" ; rdfs:subClassOf obo:CL_1000497, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001232 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001232 ] ) ] . obo:CL_1001285 obo:IAO_0000115 "A cell that is part of some vasa recta descending limb." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Vasa recta descending limb cells are specialized epithelial cells found in the vasa recta, a network of blood vessels in the renal medulla. These cells line the interior surface of the descending limb of the vasa recta and play a crucial role in the filtering and regulation of substances within the blood. In contrast to vasa recta ascending limb cells, the arterial-like epithelial cells of the descending vasa recta are non-fenestrated and covered by a pericyte layer that regulates the medullary blood flow. They help keeping the body’s fluid and electrolyte balance in check through a process known as countercurrent exchange system, in which the cells of the descending limb are permeable to water but relatively impermeable to solutes, such as sodium and urea. As the blood descends into the medulla along its descending limb, water passively diffuses out of the vasa recta, concentrating the blood in solutes. In addition to their central role in water and solute exchange, these cells contribute to maintaining the medullary osmotic gradient, a critical function to concentrate urine. The osmotic gradient is created by the counterflow of water and solutes between the descending and ascending limbs of the vasa recta and the adjacent Loop of Henle. The selective permeability of the descending limb cells allows them to maintain this gradient, which in turn helps to conserve water, a vital role in the overall function of the renal system. Thus, vasa recta descending limb cells have a significant function in renal physiology, particularly in osmoregulation and fluid balance. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001071" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "It is known in some mammalian species that this cell may express the urea transporter B." ; rdfs:label "vasa recta descending limb cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001285" ; rdfs:subClassOf obo:CL_1001036, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009202 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001036 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009202 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-descending-thin-loop-of-henle/v1.1/assets/2d-ftu-kidney-descending-thin-loop-of-henle.png" . obo:CL_1001286 obo:IAO_0000115 "Any vasa recta descending limb cell that is part of some inner medulla descending vasa recta." ; oboInOwl:hasDbXref "KUPO:0001072" ; a owl:Class ; rdfs:label "inner medulla vasa recta descending limb cell" ; rdfs:subClassOf obo:CL_1001126, obo:CL_1001285, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009089 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001285 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009089 ] ) ] . obo:CL_1001287 obo:IAO_0000115 "Any vasa recta descending limb cell that is part of some outer medulla descending vasa recta." ; oboInOwl:hasDbXref "KUPO:0001073" ; a owl:Class ; rdfs:label "outer medulla vasa recta descending limb cell" ; rdfs:subClassOf obo:CL_1001127, obo:CL_1001285, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009090 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001285 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009090 ] ) ] . obo:CL_1001318 obo:IAO_0000115 "A pericyte cell located in the kidney interstitium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001104" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "renal interstitial pericyte" ; rdfs:subClassOf obo:CL_0000669, obo:CL_1000500 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000669 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005215 ] ) ] . obo:CL_1001319 obo:IAO_0000115 "Any cell that is part of some urinary bladder." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "KUPO:0001120" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "bladder cell" ; rdfs:subClassOf obo:CL_1000600, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] . obo:CL_1001320 obo:IAO_0000115 "Any cell that is part of some urethra." ; oboInOwl:hasDbXref "KUPO:0001123" ; a owl:Class ; rdfs:label "urethra cell" ; rdfs:subClassOf obo:CL_1000600, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:CL_1001428 obo:IAO_0000115 "A urothelial cell that is part of the urothelium of the urinary bladder." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """Bladder urothelial cells form the urothelium in the bladder - a specific type of epithelial tissue that constitutes the inner lining of the bladder and other parts of the urinary tract including the renal pelvis, ureters and urethra. These unique cells are specialized to withstand the highly variable and sometimes harsh conditions present in the urinary system. Their key function is maintaining the barrier integrity of the urinary tract even when exposed to high volumes of urine and its solutes, and they play a crucial role in protecting underlying tissues from damage and infection. The bladder urothelial cells exhibit a remarkable spectrum of phenotypic versatility and have an extraordinary capacity to stretch and retract based on the degree of bladder filling and emptying. In their relaxed state, these cells appear large and cuboidal, but upon stretching, they become thinner and exhibit a squamous cell-like appearance. This distinctive feature enables them to adjust to the changes in the urinary bladder volume while remaining impermeable to urinary solutes, thereby preventing a potential toxicity to the bladder wall and infiltration into the bloodstream. Apart from their barrier function, bladder urothelial cells also express a number of sensor molecules or respond to thermal, mechanical and chemical stimuli and can release signaling molecules, thereby playing a key role in sensory mechanisms that communicate vital information about the bladder's mechanical state to the nervous system. This communication helps regulate the micturition cycle and maintain urinary continence. Recent studies have also indicated that these cells may play a role in immune responses, highlighting their importance in bladder physiology. Altered proliferation and differentiation of bladder urothelial cells are implicated in various diseases and conditions such as bladder cancer, interstitial cystitis, and urinary tract infections. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001121", "NCIT:C32210" ; oboInOwl:hasNarrowSynonym "bladder transitional cell", "transitional epithelial cell of urinary bladder" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "bladder urothelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001428" ; rdfs:subClassOf obo:CL_0000731, obo:CL_1001319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004645 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000731 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004645 ] ) ] . obo:CL_1001430 obo:IAO_0000115 "A urothelial cell that is part of the urethra urothelium. This cell plays a crucial role in maintaining the urethral barrier function, protecting against toxic substances in urine, sensing environmental changes, and defending against pathogen entry." ; terms:description """Urethra urothelial cells are highly specialized epithelial cells in the urethra, which is a tubelike structure that carries urine from the bladder to the external urethral orifice. Urothelial cells form the urothelium – a stratified, transitional epithelium lining the bladder, ureters, renal pelvis and urethra. These cells are highly adapted to their specific environment and maintain the crucial function of sustaining the urinary tract's core roles, primarily to transit and store urine without auto-corrosion or pathogen proliferation. Within the urethra urothelial cells are primarily found in proximal two-thirds of the urethra, while the distal third is lined by stratified squamous epithelial cells. The urothelial cells are renowned for their remarkable impermeability and ability to stretch and recoil during the various stages of urine filling and emptying. They form a tight barrier that prevents reabsorption of harmful byproducts and toxic substances present in the urine, guarding the deeper tissues and bloodstream against potential damage. This is largely attributed to specialized junctions, namely zonulae occludentes or tight junctions, in the umbrella cell layer (one of three layers of the urothelium) that seal the intercellular space between adjacent cells. Together with the urothelial plaque (an apical membrane plaque comprised of uroplakin proteins covering the umbrella cells at the luminal surface), the junctional complexes form a very effective permeability barrier that regulates the passage of water and ion from urine to the underlying tissue. A noteworthy feature of urothelial cells is their regulatory and sensory roles involving communication with the underlying layers about the filling and emptying status of the urinary tract. The cells also manage a fine balance between proliferation and differentiation, with the basal cells providing a ready pool of cells to replace the superficial layer when damaged. Their remarkable ability for regeneration and turnover, and their response to signals for repair underpins the durability and functionality of the urothelial tract. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001124" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "urethra urothelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001430" ; rdfs:subClassOf obo:CL_0000731, obo:CL_1000296, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004787 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000731 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004787 ] ) ] . obo:CL_1001431 obo:IAO_0000115 "Any renal principal cell that is part of some collecting duct of renal tubule." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """The kidney collecting duct principal cell is a highly specialized type of cell found in the late distal convoluted tubule and collecting duct of the kidney's nephron. Principal cells are located at the final segments of the renal tubules, where they play a pivotal role in key homeostatic processes. One of their fundamental functions of kidney collecting duct principal cells is the regulation of water reabsorption, which is mediated by aquaporins (water channel proteins). Antidiuretic hormones, such as vasopressin, can stimulate the redistribution of these water channels from an intracellular pools to the apical plasma membrane of the principal cell; translocation of aquaporin (specifically, AQP2) is associated with an increase of osmotic water permeability. The water reabsorption affects the concentration of the final urine; these cells are therefore directly involved in the maintenance of the body's fluid balance. Kidney collecting duct principal cells also participate in sodium and potassium ions regulation. They reabsorb sodium ions from the tubular fluid back into the bloodstream, a process facilitated by the action of aldosterone, a hormone released by the adrenal glands. Similarly, the principal cells secrete potassium ions into the tubular fluid in response to aldosterone, contributing to the regulation of potassium levels in the body. Impaired function of cells can lead to various renal diseases and disorders, highlighting the vital role of kidney collecting duct principal cells in the body's homeostatic processes. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001128" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney collecting duct principal cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001431" ; rdfs:subClassOf obo:CL_0005009, obo:CL_1000454 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001232 ] ) ] . obo:CL_1001432 obo:IAO_0000115 "Any renal intercalated cell that is part of some collecting duct of renal tubule." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:description """The kidney collecting duct intercalated cell, otherwise referred to simply as the intercalated cell, is a specialized epithelial cell type primarily found in the kidney's collecting duct system. It is among the main cells that line this final component of the nephron, crucial in the physiological system that maintains acid-base homeostasis. This unique cell type comes in mainly three subtypes as per the localization of their proton pumps: type A, type B, and non-A, non-B cells. Each subtype plays different roles in regulating acid-base balance and electrolyte homeostasis in the body under varying physiological conditions. Type A intercalated cells reabsorb bicarbonate and secrete protons into urine, leading to the production of acidic urine. These cells are typically prevalent on the renal cortex and function particularly in states of metabolic acidosis or potassium depletion. On the other hand, type B intercalated cells secrete bicarbonate and reabsorb protons; thus, they are crucial in alkaline urine production and potassium conservation. These cells are essential to counter metabolic alkalosis or situations of potassium surplus. The non-A, non-B cells have the characteristic features of both type A and B cells, but play a prominent role under conditions of chronically elevated aldosterone and angiotensin II levels. Through their differentiated roles, intercalated cells also facilitate the reabsorption of sodium and chloride ions, and water to maintain osmolarity. These cells' activity is finely regulated by hormonal signals like aldosterone, angiotensin II, vasopressin, and the parathyroid hormone. Intercalated cell activity can undergo a significant transformation under pathological conditions, and their dysregulation is associated with diseases such as distal renal tubular acidosis, hypertension, and chronic kidney disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "KUPO:0001129", "http://en.wikipedia.org/wiki/Collecting_duct_system#Intercalated_cells" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney collecting duct intercalated cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001432" ; rdfs:subClassOf obo:CL_0005010, obo:CL_1000454 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005010 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001232 ] ) ] . obo:CL_1001433 obo:IAO_0000115 "An epithelial cell of the exocrine pancreas." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "FMA:70986" ; oboInOwl:hasExactSynonym "exocrine pancreas cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "epithelial cell of exocrine pancreas" ; rdfs:subClassOf obo:CL_0000083, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000017 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000017 ] ) ] . obo:CL_1001434 obo:IAO_0000115 "A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons" ; a owl:Class ; rdfs:label "olfactory bulb interneuron" ; rdfs:subClassOf obo:CL_0000099, obo:CL_0000101, obo:CL_0012001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002264 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002264 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002264 ] ) ] ; skos:prefLabel "olfactory bulb interneuron" . obo:CL_1001435 obo:IAO_0000115 "The small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter." ; oboInOwl:hasDbXref "BTO:0003796", "NIFEXT:122" ; oboInOwl:hasExactSynonym "glomerular layer cell", "olfactory bulb (accessory) glomerular layer cell", "olfactory bulb glomerular layer cell", "olfactory bulb glomerularal cell", "olfactory bulb periglomerular cell" ; a owl:Class ; rdfs:label "periglomerular cell" ; rdfs:subClassOf obo:CL_1001434, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005377 ] . obo:CL_1001436 obo:IAO_0000115 "The subcutaneous mechanoreceptors that innervate tylotrich hair follicles." ; a owl:Class ; rdfs:label "hair-tylotrich neuron" ; rdfs:subClassOf obo:CL_0002487 . obo:CL_1001437 obo:IAO_0000115 "The subcutaneous mechanoreceptors that innervate vellus hairs." ; a owl:Class ; rdfs:label "hair-down neuron" ; rdfs:subClassOf obo:CL_0002487 . obo:CL_1001451 obo:IAO_0000115 "A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord." ; oboInOwl:hasExactSynonym "proprioceptive neuron" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "sensory neuron of dorsal root ganglion" ; rdfs:subClassOf obo:CL_0000006, obo:CL_3000004, obo:CL_4023168, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000044 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000044 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000101 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000044 ] ) ] . obo:CL_1001474 obo:IAO_0000115 "An inhibitory, GABAergic projection neuron in the striatum that integrates glutamatergic signals arising from the cerebral cortex and thalamus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0004778" ; oboInOwl:hasExactSynonym "gamma-aminobutyric acid (GABA)ergic spiny projection neuron", "gamma-aminobutyric acid ergic spiny projection neuron", "striatal medium spiny neuron" ; oboInOwl:hasRelatedSynonym "medium-sized densely spiny neuron" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "medium spiny neuron" ; rdfs:subClassOf obo:CL_0000617, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000369 ] . obo:CL_1001502 obo:IAO_0000115 "The large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex." ; a owl:Class ; rdfs:label "mitral cell" ; rdfs:subClassOf obo:CL_1001434, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0004186 ] ; skos:prefLabel "mitral cell" . obo:CL_1001503 obo:IAO_0000115 "The principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala." ; a owl:Class ; rdfs:label "olfactory bulb tufted cell" ; rdfs:subClassOf obo:CL_0012001, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005376 ] ; skos:prefLabel "olfactory bulb tufted cell" . obo:CL_1001505 obo:IAO_0000115 "The secretory neurons of the paraventricular nucleus that synthesize and secrete vasopressin, corticotropin-releasing factor (CRF) and thyrotropin-releasing hormone (TRH) into blood vessels in the hypothalamo-pituitary portal system." ; oboInOwl:hasExactSynonym "parvocellular neuron", "parvocellular neurosecretory neuron" ; a owl:Class ; rdfs:label "parvocellular neurosecretory cell" ; rdfs:subClassOf obo:CL_0000165, obo:CL_0000167, obo:CL_0012001, obo:CL_2000030, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001930 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030103 ] . obo:CL_1001509 obo:IAO_0000115 "The neurons that utilize glycine as a neurotransmitter." ; oboInOwl:hasDbXref "FBbt:00048032", "ZFA:0009396" ; a owl:Class ; rdfs:label "glycinergic neuron" ; rdfs:subClassOf obo:CL_0000151, obo:CL_0000540, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061537 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061537 ] ) ] . obo:CL_1001516 obo:IAO_0000115 "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract." ; terms:description """Intestinal enteroendocrine cells are a highly specialized cell type found within the gastrointestinal epithelium. They account for approximately 1% of the intestinal epithelial cells in what is known as the largest endocrine organ in the human body. Intestinal enteroendocrine cells exhibit an exceptional diversity, both in terms of their secretory products and their distribution along the intestines, varying from the small intestine to the colon. The primary function of intestinal enteroendocrine cells is to maintain gut physiology and homeostasis. They are known for their hormone production and are the source of numerous bioactive molecules including somatostatin, serotonin, cholecystokinin, glucose-dependent insulinotropic peptide, motilin, neurotensin, and others. These hormones and neuropeptides act in autocrine, paracrine, or endocrine signaling, impacting various functions including intestinal motility, secretion, nutrient absorption, and gut barrier functions. Intestinal enteroendocrine cells also serve as the body's frontline of defense, playing an integral role in surveillance against lumen-occurring hazards including pathogen attack. Enteroendocrine cells are divided into ‘closed type’ and ‘open type’. Closed type cells are located close to the basal membrane and do not reach the lumen of the gut. In contrast, the apical side of the open-type intestinal enteroendocrine cells is directly exposed to luminal contents and thus can recognize bacterial metabolites and dietary nutrients. In response, these cells can modulate the immune system responses and thereby function as a key communicator between the gut microbiota and the host. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "intestinal enteroendocrine cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001516" ; rdfs:subClassOf obo:CL_0000164, obo:CL_0002563, [ a owl:Restriction ; owl:onProperty obo:RO_0002207 ; owl:someValuesFrom obo:CL_4052006 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000164 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001277 ] ) ] . obo:CL_1001517 obo:IAO_0000115 "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach." ; a owl:Class ; rdfs:label "stomach enteroendocrine cell" ; rdfs:subClassOf obo:CL_0000164, obo:CL_0002178 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000164 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] . obo:CL_1001561 obo:IAO_0000115 "Chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals." ; a owl:Class ; rdfs:label "vomeronasal sensory neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000101, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002255 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013007 ; owl:someValuesFrom obo:UBERON_0003367 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000101 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0013007 ; owl:someValuesFrom obo:UBERON_0003367 ] ) ] . obo:CL_1001566 obo:IAO_0000115 "OBSOLETE. A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and club cells in response to lung injury." ; obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0002638 ; a owl:Class ; rdfs:comment "Duplicated term - merged into CL:0002638" ; rdfs:label "obsolete bronchioalveolar stem cells" ; owl:deprecated true . obo:CL_1001567 obo:IAO_0000115 "Any endothelial cell of vascular tree that is part of some lung." ; oboInOwl:hasRelatedSynonym "endothelial cell of lung", "pulmonary vessel endothelial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "lung endothelial cell" ; rdfs:subClassOf obo:CL_0002139, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000102 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002139 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:CL_1001568 obo:IAO_0000115 "Any endothelial cell of vascular tree that is part of some pulmonary artery." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0001141" ; oboInOwl:hasRelatedSynonym "PAEC cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "pulmonary artery endothelial cell" ; rdfs:subClassOf obo:CL_1000413, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005317 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002139 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002012 ] ) ] . obo:CL_1001569 obo:IAO_0000115 "An interneuron with a soma found in the hippocampus." ; oboInOwl:hasDbXref "FMA:84777" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "hippocampal interneuron" ; rdfs:subClassOf obo:CL_0002608, obo:CL_0008031 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002421 ] ) ] . obo:CL_1001571 obo:IAO_0000115 "A pyramidal neuron with a soma found in the hippocampus." ; oboInOwl:hasDbXref "NIFSTD:sao131261273", "SAO:sao131261273" ; oboInOwl:hasNarrowSynonym "hippocampus (CA) pyramidal cell", "hippocampus (CA) pyramidal neuron" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "hippocampal pyramidal neuron" ; rdfs:subClassOf obo:CL_0002608, obo:CL_4023111, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002313 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000598 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002421 ] ) ] . obo:CL_1001572 obo:IAO_0000115 "A vascular endothelial cell found in colon blood vessels." ; oboInOwl:hasDbXref "CALOHA:TS-2397" ; oboInOwl:hasRelatedSynonym "colon endothelial cells", "colonic endothelial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "colon endothelial cell" ; rdfs:subClassOf obo:CL_0000131, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013695 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:CL_1001573 obo:IAO_0000115 "Cell of the nasopharyngeal epithelium." ; oboInOwl:hasDbXref "CALOHA:TS-2398" ; oboInOwl:hasRelatedSynonym "nasopharynx respiratory epithelial cells" ; a owl:Class ; rdfs:label "nasopharyngeal epithelial cell" ; rdfs:subClassOf obo:CL_0002251, obo:CL_0002631, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001951 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001728 ] ) ] . obo:CL_1001575 obo:IAO_0000115 "Squamous cell of uterine cervix epithelium." ; oboInOwl:hasDbXref "CALOHA:TS-1251" ; oboInOwl:hasRelatedSynonym "cervix squamous cell", "cervix squamous epithelial cell", "cervix, uterine squamous epithelial cells", "uterine cervix squamous epithelial cell", "uterine cervix squamous epithelial cells" ; a owl:Class ; rdfs:label "uterine cervix squamous cell" ; rdfs:subClassOf obo:CL_0000076, obo:CL_0002535 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000002 ] ) ] . obo:CL_1001576 obo:IAO_0000115 "Squamous cell of oral epithelium." ; oboInOwl:hasDbXref "CALOHA:TS-1252" ; oboInOwl:hasRelatedSynonym "oral cavity mucosa squamous cell", "oral cavity mucosa squamous epithelial cell", "oral mucosa squamous epithelial cell", "oral mucosa squamous epithelial cells" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "oral mucosa squamous cell" ; rdfs:subClassOf obo:CL_0000076, obo:CL_0002251, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002424 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002424 ] ) ] . obo:CL_1001577 obo:IAO_0000115 "Squamous cell of tonsil epithelium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "CALOHA:TS-1253" ; oboInOwl:hasRelatedSynonym "tonsil squamous epithelial cell", "tonsil squamous epithelial cells", "tonsillar squamous cell", "tonsillar squamous epithelial cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "tonsil squamous cell" ; rdfs:subClassOf obo:CL_0000076, obo:CL_0002251, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013696 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002372 ] ) ] . obo:CL_1001578 obo:IAO_0000115 "Squamous cell of vaginal epithelium." ; oboInOwl:hasDbXref "CALOHA:TS-1254" ; oboInOwl:hasRelatedSynonym "vagina squamous epithelial cell", "vagina squamous epithelial cells", "vaginal squamous cell", "vaginal squamous epithelial cell" ; a owl:Class ; rdfs:label "vagina squamous cell" ; rdfs:subClassOf obo:CL_0000076, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001344 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] . obo:CL_1001579 obo:IAO_0000115 "Glial cell of cerebral cortex." ; oboInOwl:hasDbXref "CALOHA:TS-1256" ; oboInOwl:hasRelatedSynonym "brain cortex glial cell", "cerebral cortex glial cells", "cerebrum cortex glial cell" ; a owl:Class ; rdfs:label "cerebral cortex glial cell" ; rdfs:subClassOf obo:CL_0000125, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000956 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] . obo:CL_1001580 obo:IAO_0000115 "A glial cell that is part of the hippocampus." ; oboInOwl:hasDbXref "CALOHA:TS-1257" ; oboInOwl:hasExactSynonym "hippocampus glial cell", "hippocampus neuroglial cell" ; a owl:Class ; rdfs:label "hippocampal glial cell" ; rdfs:subClassOf obo:CL_1001579, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002421 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002421 ] ) ] . obo:CL_1001581 obo:IAO_0000115 "Glial cell of lateral ventricle." ; oboInOwl:hasDbXref "CALOHA:TS-1258" ; oboInOwl:hasRelatedSynonym "lateral ventricle glial cells" ; a owl:Class ; rdfs:label "lateral ventricle glial cell" ; rdfs:subClassOf obo:CL_0000125, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002285 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002285 ] ) ] . obo:CL_1001582 obo:IAO_0000115 "Neuron of lateral ventricle." ; oboInOwl:hasDbXref "CALOHA:TS-1261" ; oboInOwl:hasRelatedSynonym "lateral ventricle neural cell", "lateral ventricle neuronal cell", "lateral ventricle neuronal cells" ; a owl:Class ; rdfs:label "lateral ventricle neuron" ; rdfs:subClassOf obo:CL_0012001, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002285 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002285 ] ) ] . obo:CL_1001583 obo:IAO_0000115 "OBSOLETE: Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma." ; obo:IAO_0100001 obo:CL_0002617 ; oboInOwl:hasRelatedSynonym "breast adipocytes" ; a owl:Class ; rdfs:label "obsolete breast adipocyte" ; owl:deprecated true . obo:CL_1001585 obo:IAO_0000115 "Glandular cell of appendix epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." ; oboInOwl:hasDbXref "CALOHA:TS-1271" ; oboInOwl:hasRelatedSynonym "appendix glandular cells", "caecal appendix glandular cell", "cecal appendix glandular cell", "vermiform appendix glandular cell" ; a owl:Class ; rdfs:label "appendix glandular cell" ; rdfs:subClassOf obo:CL_0002658, obo:CL_1000405 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001154 ] ) ] . obo:CL_1001586 obo:IAO_0000115 "Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts." ; oboInOwl:hasDbXref "CALOHA:TS-1272" ; oboInOwl:hasRelatedSynonym "breast glandular cell", "breast glandular cells", "mammary glandular cell" ; a owl:Class ; rdfs:label "mammary gland glandular cell" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000152, obo:CL_0002327, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003244 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ) ] . obo:CL_1001587 obo:IAO_0000115 "Glandular cell of uterine cervix epithelium." ; oboInOwl:hasDbXref "CALOHA:TS-1273" ; oboInOwl:hasRelatedSynonym "cervix glandular cell", "cervix, uterine glandular cell", "cervix, uterine glandular cells", "uterine cervix glandular cell" ; a owl:Class ; rdfs:label "uterine cervix secretory cell" ; rdfs:subClassOf obo:CL_0002535, obo:CL_1001591 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1100001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000002 ] ) ] . obo:CL_1001588 obo:IAO_0000115 "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." ; oboInOwl:hasDbXref "CALOHA:TS-1274" ; oboInOwl:hasRelatedSynonym "colon glandular cells" ; a owl:Class ; rdfs:label "colon glandular cell" ; rdfs:subClassOf obo:CL_0002658, obo:CL_0011108 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:CL_1001589 obo:IAO_0000115 "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell." ; oboInOwl:hasDbXref "CALOHA:TS-1275" ; oboInOwl:hasNarrowSynonym "duodenum glandular cells" ; a owl:Class ; rdfs:label "duodenum secretory cell" ; rdfs:subClassOf obo:CL_1001598, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008346 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1100001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] . obo:CL_1001590 obo:IAO_0000115 "Glandular cell of epididymal epithelium." ; oboInOwl:hasDbXref "CALOHA:TS-1276" ; oboInOwl:hasRelatedSynonym "epididymal glandular cell", "epididymis glandular cell" ; a owl:Class ; rdfs:label "epididymis secretory cell" ; rdfs:subClassOf obo:CL_0000068, obo:CL_1100001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004544 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1100001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001301 ] ) ] . obo:CL_1001591 obo:IAO_0000115 "Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells." ; oboInOwl:hasDbXref "CALOHA:TS-1277" ; oboInOwl:hasRelatedSynonym "fallopian tube glandular cell", "fallopian tube glandular cells", "oviduct glandular cell", "uterine tube glandular cell" ; a owl:Class ; rdfs:label "oviduct secretory cell" ; rdfs:subClassOf obo:CL_1100001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004804 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1100001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000993 ] ) ] . obo:CL_1001592 obo:IAO_0000115 "Glandular cell of gallbladder epithelium." ; oboInOwl:hasDbXref "CALOHA:TS-1278" ; oboInOwl:hasExactSynonym "gall bladder glandular cell" ; oboInOwl:hasRelatedSynonym "gall bladder glandular cells", "gallbladder glandular cells" ; a owl:Class ; rdfs:label "gallbladder glandular cell" ; rdfs:subClassOf obo:CL_0000150, obo:CL_1000415, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002029 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002110 ] ) ] . obo:CL_1001593 obo:IAO_0000115 "Glandular (secretory) cell of parathyroid epithelium." ; oboInOwl:hasDbXref "CALOHA:TS-1279" ; oboInOwl:hasRelatedSynonym "parathyroid gland glandular cell", "parathyroid gland glandular cells" ; a owl:Class ; rdfs:label "parathyroid glandular cell" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0002260 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001132 ] ) ] . obo:CL_1001595 obo:IAO_0000115 "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells." ; oboInOwl:hasDbXref "CALOHA:TS-1281" ; oboInOwl:hasRelatedSynonym "rectal glandular cell", "rectum glandular cells" ; a owl:Class ; rdfs:label "rectum glandular cell" ; rdfs:subClassOf obo:CL_0002658, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003354 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001052 ] ) ] . obo:CL_1001596 obo:IAO_0000115 "Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts." ; oboInOwl:hasDbXref "CALOHA:TS-1282" ; oboInOwl:hasRelatedSynonym "salivary gland glandular cells" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "salivary gland glandular cell" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000152, obo:CL_0002251, obo:CL_0009005, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004809 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001044 ] ) ] . obo:CL_1001597 obo:IAO_0000115 "Glandular cell of seminal vesicle epithelium." ; terms:description """Seminal vesicle glandular cells belong to a specialized group of epithelial cells that form the internal lining of the seminal vesicles, a pair of male reproductive organs. These cells are located within the complex tubuloalveolar glands that make up the seminal vesicles and are known for their unique pseudostratified columnar epithelium structure. The primary function of these cells is the secretion of a variety of substances that ultimately constitute around 70% of the fluid volume of semen. Seminal cells produce a high-fructose fluid that serves as an energy source for the spermatozoa and promotes their motility. They also secrete other essential substances like proteins, enzymes, vitamin C, prostaglandins, and various other compounds. Collectively, these substances help in the nourishment, protection, and transportation of the spermatozoa throughout the male reproductive system and during the ejaculation process. Secondary to the production of seminal fluid, the seminal vesicle glandular cells also play a role in the contraction of the seminal vesicles during ejaculation. The contraction of these glands, induced by sympathetic nerves, ensures the efficient propulsion of the seminal fluid mixed with spermatozoa into the ejaculatory ducts and subsequently to the urethra. Notably, any malfunction or pathological condition affecting these cells can impact male fertility, emphasizing the importance of understanding the intricate functions of seminal vesicle glandular cells in maintaining the healthy physiological function of male reproduction. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "CALOHA:TS-1283" ; oboInOwl:hasRelatedSynonym "seminal vesicle glandular cells" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "seminal vesicle glandular cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001597" ; rdfs:subClassOf obo:CL_0000068, obo:CL_0000150, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004805 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000998 ] ) ] . obo:CL_1001598 obo:IAO_0000115 "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ." ; oboInOwl:hasDbXref "CALOHA:TS-1286", "FMA:86928" ; oboInOwl:hasNarrowSynonym "small intestinal glandular cell" ; oboInOwl:hasRelatedSynonym "small bowel glandular cell", "small intestine glandular cells" ; a owl:Class ; rdfs:label "small intestine secretory cell" ; rdfs:subClassOf obo:CL_0002254, obo:CL_1100001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001902 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1100001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:CL_1001599 obo:IAO_0000115 "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "BTO:0000028", "CALOHA:TS-1242" ; oboInOwl:hasRelatedSynonym "exocrine pancreas glandular cell", "pancreas exocrine glandular cells" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreas exocrine glandular cell" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000152, obo:CL_1001433, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013697 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000017 ] ) ] . obo:CL_1001601 obo:IAO_0000115 "Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens." ; oboInOwl:hasDbXref "CALOHA:TS-2177" ; oboInOwl:hasRelatedSynonym "adrenal gland glandular cells", "adrenal glandular cell", "suprarenal gland glandular cell" ; a owl:Class ; rdfs:label "adrenal gland glandular cell" ; rdfs:subClassOf obo:CL_0000150, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001235 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001235 ] ) ] . obo:CL_1001602 obo:IAO_0000115 "A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex." ; terms:description """Cerebral cortex endothelial cells are unique endothelial cells responsible for the formation and regulation of the blood-brain barrier (BBB), a specialized structure that separates the circulating blood from the cerebral neural tissue. These cells line the inner surface of nearly all blood vessels that irrigate the cerebral cortex, the outermost layer of the brain involved with complex cognitive functions such as thought, perception, and memory formation. Cerebral cortex endothelial cells are integral to maintaining brain health and function due to their role in regulating brain microenvironment and controlling the passage of essential molecules and cells. The endothelial cells in the cerebral cortex are distinctive due to their highly selective permeability, largely attributable to the existence of unique tight junctions which maintain the barrier function of the BBB. The tightly interconnected structures of these cells prevent most substances from freely diffusing into the brain tissue, ensuring that harmful agents such as toxins, pathogens, or peripheral immune cells don't reach the brain and compromise its function. These cells also express multiple transporters and enzymes, allowing the selective entry of necessary nutrients and metabolites while excluding toxic substances. Cerebral cortex endothelial cells also participate in neurovascular coupling, a process where localized neuronal activity increases cerebral blood flow to satisfy the local metabolic demands. The endothelial cells work in coordination with neurons and other cell types such as astrocytes and pericytes to mediate this process. They have been thought to regulate local blood flow by releasing substances in response to neuronal activity. Additionally, these cells are involved in many pathological conditions. Breakdown or dysfunction of the BBB often marked by altered endothelial cell function is linked to numerous neurological disorders including stroke, multiple sclerosis, Alzheimer’s disease, and brain tumors. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "CALOHA:TS-2372" ; oboInOwl:hasRelatedSynonym "cerebral cortex endothelial cells", "endothelial cells of cerebral cortex" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cerebral cortex endothelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001602" ; rdfs:subClassOf obo:CL_0000115, obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000956 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013694 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] . obo:CL_1001603 obo:IAO_0000115 "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung." ; terms:description """Lung macrophages refer to macrophage populations in the lungs, including the tissue-resident alveolar macrophages and interstitial macrophages, located in the air spaces and the connective tissue of the lung, respectively, and recruited macrophages. They are important in maintaining tissue homeostasis and immunity. The primary function of lung macrophages is to patrol and maintain the pulmonary system, where they serve as the first line of defense against airborne pathogens and inhaled particles. They perform phagocytosis of pathogens, particulate matter, dead cells, and other cellular debris from the lungs to maintain clear air passages and optimize gas exchange. They may also participate in tissue repair and the resolution of inflammation following injury. Lung macrophages also play a critical role in immune regulation. They help to initiate an immune response by secreting cytokines and other inflammatory mediators and by presenting antigens from the pathogens they have engulfed to induce T cell responses. However, if activated improperly, lung macrophages can contribute to inflammatory diseases of the lung such as chronic obstructive pulmonary disease (COPD) or asthma. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:hasDbXref "CALOHA:TS-0576" ; oboInOwl:hasRelatedSynonym "lung macrophages" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "lung macrophage" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001603" ; rdfs:subClassOf obo:CL_0000235, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000235 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:CL_1001606 obo:IAO_0000115 "Keratinocyte from foreskin." ; oboInOwl:hasDbXref "CALOHA:TS-0385" ; a owl:Class ; rdfs:label "foreskin keratinocyte" ; rdfs:subClassOf obo:CL_0000312, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001332 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000312 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001332 ] ) ] . obo:CL_1001607 obo:IAO_0000115 "Chondrocyte forming the hyaline cartilage found in joints." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasDbXref "CALOHA:TS-0056" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "articular chondrocyte" ; rdfs:subClassOf obo:CL_0000138, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010996 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000138 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010996 ] ) ] . obo:CL_1001608 obo:IAO_0000115 "Fibroblast from foreskin." ; oboInOwl:hasDbXref "CALOHA:TS-0384" ; oboInOwl:hasExactSynonym "BJ fibroblast" ; a owl:Class ; rdfs:label "foreskin fibroblast" ; rdfs:subClassOf obo:CL_0002620, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001332 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002620 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001332 ] ) ] . obo:CL_1001609 obo:IAO_0000115 "Fibroblast from muscle organ." ; oboInOwl:hasDbXref "CALOHA:TS-0643" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "muscle fibroblast" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001630 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001630 ] ) ] . obo:CL_1001610 obo:IAO_0000115 "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." ; oboInOwl:hasDbXref "CALOHA:TS-2109" ; oboInOwl:hasRelatedSynonym "bone marrow hematopoietic cells", "bone marrow poietic cells" ; a owl:Class ; rdfs:label "bone marrow hematopoietic cell" ; rdfs:subClassOf obo:CL_0000988, obo:CL_0002092, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012429 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000988 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] ) ] . obo:CL_1001611 obo:IAO_0000115 "Neuron of the cerebellum." ; oboInOwl:hasDbXref "CALOHA:TS-2359", "FMA:84665" ; oboInOwl:hasRelatedSynonym "cerebellum neuron" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cerebellar neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002037 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] ; skos:prefLabel "cerebellar neuron" . obo:CL_1100001 obo:IAO_0000115 "An epithelial cell that is specialised for the synthesis and secretion of specific biomolecules." ; terms:contributor ; terms:date "2024-07-21T09:24:44Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "secretory epithelial cell"@en ; rdfs:subClassOf obo:CL_0000066, obo:CL_0000151 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 obo:CL_0000151 ) ] ; skos:prefLabel "secretory epithelial cell" . obo:CL_2000000 obo:IAO_0000115 "Any melanocyte that is part of a epidermis." ; terms:contributor ; oboInOwl:creation_date "2014-02-03T23:03:09Z"^^xsd:dateTime ; oboInOwl:id "CL:2000000" ; a owl:Class ; rdfs:comment "These cells are found primarily, but not exclusively, in primates including humans" ; rdfs:label "epidermal melanocyte" ; rdfs:subClassOf obo:CL_0002484, obo:CL_1000458, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] ) ] . obo:CL_2000001 obo:IAO_0000115 "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." ; terms:contributor ; oboInOwl:creation_date "2014-02-11T17:29:04Z"^^xsd:dateTime ; oboInOwl:id "CL:2000001" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "peripheral blood mononuclear cell" ; rdfs:subClassOf obo:CL_0000080, obo:CL_0000842, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] . obo:CL_2000002 obo:IAO_0000115 "A specialized, enlarged, connective tissue cell of the decidua with enlarged nucleus, dense membrane‐bound secretory granules and cytoplasmic accumulation of glycogen and lipid droplets. These cells develop by the transformation of endometrial stromal cells during decidualization." ; terms:description """Decidual cells, originating from the endometrial lining in the uterus, undergo significant transformations during pregnancy and are integral to its preparation and maintenance. Their conversion from endometrial fibroblast to a secretory phenotype, known as decidualization, occurs as a normal process in the menstrual cycle or in response to embryo implantation. With crucial roles in regulating maternal immune responses and placental development, decidual cells have a twofold function: preventing rejection of the conceptus by the mother's immune system and guiding placental development to avoid excessive trophoblast invasion leading to pre-eclampsia. During decidualization, these cells secrete proteins and growth factors supporting embryo implantation and sustaining early pregnancy. Furthermore, decidual cells modulate the activities of natural killer cells, macrophages, and T cells in the uterus, maintaining a balance of pro-inflammatory and anti-inflammatory conditions during pregnancy. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2014-02-20T23:06:41Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0002770", "BTO:0005756", "NCIT:C32429" ; oboInOwl:hasExactSynonym "decidua cell", "decidual stromal cell", "decidualized endometrial stromal cell" ; oboInOwl:id "CL:2000002" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "decidual cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000002" ; rdfs:subClassOf obo:CL_0000349, obo:CL_0000499, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002450 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002255 ] . obo:CL_2000004 obo:IAO_0000115 "Any cell that is part of a pituitary gland." ; terms:contributor ; oboInOwl:creation_date "2014-03-26T22:14:56Z"^^xsd:dateTime ; oboInOwl:id "CL:2000004" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "pituitary gland cell" ; rdfs:subClassOf obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000007 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000007 ] ) ] ; skos:prefLabel "pituitary gland cell" . obo:CL_2000005 obo:IAO_0000115 "Any macroglial cell that is part of a brain." ; terms:contributor ; oboInOwl:creation_date "2014-03-28T21:35:27Z"^^xsd:dateTime ; oboInOwl:id "CL:2000005" ; a owl:Class ; rdfs:label "brain macroglial cell" ; rdfs:subClassOf obo:CL_0000126, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000126 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:CL_2000006 obo:IAO_0000115 "Any germinal center B cell that is part of a tonsil." ; terms:contributor ; oboInOwl:creation_date "2014-03-28T21:35:33Z"^^xsd:dateTime ; oboInOwl:id "CL:2000006" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "tonsil germinal center B cell" ; rdfs:subClassOf obo:CL_0000844, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002372 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002372 ] ) ] . obo:CL_2000007 obo:IAO_0000115 "Chondrocyte forming the hyaline cartilage found in the knee joint." ; terms:contributor ; oboInOwl:creation_date "2014-06-04T14:40:11Z"^^xsd:dateTime ; oboInOwl:id "CL:2000007" ; a owl:Class ; rdfs:label "articular chondrocyte of knee joint" ; rdfs:subClassOf obo:CL_1001607, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001607 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001485 ] ) ] . obo:CL_2000008 obo:IAO_0000115 "Any blood vessel endothelial cell that is part of a microvascular endothelium." ; terms:contributor ; oboInOwl:creation_date "2014-06-04T15:07:42Z"^^xsd:dateTime ; oboInOwl:id "CL:2000008" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "microvascular endothelial cell" ; rdfs:subClassOf obo:CL_0000071, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008339 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000071 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008339 ] ) ] . obo:CL_2000009 obo:IAO_0000115 "Any blood vessel endothelial cell that is part of a microvascular endothelium." ; obo:IAO_0100001 obo:CL_2000008 ; terms:contributor ; oboInOwl:creation_date "2014-06-04T15:09:18Z"^^xsd:dateTime ; oboInOwl:id "CL:2000009" ; a owl:Class ; rdfs:label "obsolete microvascular endothelium blood vessel endothelial cell" ; owl:deprecated true . obo:CL_2000010 obo:IAO_0000115 "Any blood vessel endothelial cell that is part of a dermis." ; terms:contributor ; oboInOwl:creation_date "2014-06-04T15:12:06Z"^^xsd:dateTime ; oboInOwl:id "CL:2000010" ; a owl:Class ; rdfs:label "dermis blood vessel endothelial cell" ; rdfs:subClassOf obo:CL_0000071, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000071 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] ) ] . obo:CL_2000011 obo:IAO_0000115 "Any endothelial cell of lymphatic vessel that is part of a dermis." ; terms:contributor ; terms:description """A dermis lymphatic vessel endothelial cell is a specialized type of cell that lines the interior surface of lymphatic vessels present in the dermal layer of the skin. These cells are organized into a single layer, forming an integral part of the lymphatic system which acts as the body's secondary circulatory system. The primary function of dermis lymphatic vessel endothelial cells is to facilitate the transportation and regulation of the lymph fluid within the dermis. They act as a barrier, contributing to fluid homeostasis, lipid transport, and immune cell trafficking. These cells are uniquely equipped to let fluid and larger molecules, including proteins and immune cells, into the lymphatic vessels from the surrounding interstitial space. This is enabled by the specialized junctions between the endothelial cells and the presence of primary lymphatic valves that prevent the backflow of lymph. Another paramount role of dermis lymphatic vessel endothelial cells is their involvement in immune response. By interacting with white blood cells, especially T-cells and dendritic cells, they can mediate local immune surveillance and contribute to both innate and adaptive immune responses. These cells are also implicated in a variety of pathological conditions, including lymphedema and metastasis in cancer. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2014-06-04T15:15:08Z"^^xsd:dateTime ; oboInOwl:id "CL:2000011" ; a owl:Class ; rdfs:label "dermis lymphatic vessel endothelial cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000011" ; rdfs:subClassOf obo:CL_0002138, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002138 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] ) ] . obo:CL_2000012 obo:IAO_0000115 "Any skin fibroblast that is part of a pedal digit skin." ; terms:contributor ; oboInOwl:creation_date "2014-06-04T15:16:44Z"^^xsd:dateTime ; oboInOwl:id "CL:2000012" ; a owl:Class ; rdfs:label "fibroblast of pedal digit skin" ; rdfs:subClassOf obo:CL_0002620, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003530 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002620 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003530 ] ) ] . obo:CL_2000013 obo:IAO_0000115 "Any skin fibroblast that is part of a skin of abdomen." ; terms:contributor ; oboInOwl:creation_date "2014-06-04T15:18:16Z"^^xsd:dateTime ; oboInOwl:id "CL:2000013" ; a owl:Class ; rdfs:label "fibroblast of skin of abdomen" ; rdfs:subClassOf obo:CL_0002620, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001416 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002620 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001416 ] ) ] . obo:CL_2000014 obo:IAO_0000115 "Any skin fibroblast that is part of a upper leg skin." ; terms:contributor ; oboInOwl:creation_date "2014-06-04T15:19:44Z"^^xsd:dateTime ; oboInOwl:id "CL:2000014" ; a owl:Class ; rdfs:label "fibroblast of upper leg skin" ; rdfs:subClassOf obo:CL_0002620, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004262 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002620 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004262 ] ) ] . obo:CL_2000015 obo:IAO_0000115 "Any skin fibroblast that is part of a arm." ; terms:contributor ; oboInOwl:creation_date "2014-06-04T15:29:06Z"^^xsd:dateTime ; oboInOwl:id "CL:2000015" ; a owl:Class ; rdfs:label "fibroblast of arm" ; rdfs:subClassOf obo:CL_0002620, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001460 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002620 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001460 ] ) ] . obo:CL_2000016 obo:IAO_0000115 "Any lung endothelial cell that is part of a microvascular endothelium." ; terms:contributor ; oboInOwl:creation_date "2014-06-04T16:00:56Z"^^xsd:dateTime ; oboInOwl:id "CL:2000016" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "lung microvascular endothelial cell" ; rdfs:subClassOf obo:CL_1001567, obo:CL_2000008 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001567 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008339 ] ) ] . obo:CL_2000017 obo:IAO_0000115 "Any fibroblast that is part of a periodontal ligament." ; terms:contributor ; oboInOwl:creation_date "2014-06-04T16:50:33Z"^^xsd:dateTime ; oboInOwl:id "CL:2000017" ; a owl:Class ; rdfs:label "fibroblast of peridontal ligament" ; rdfs:subClassOf obo:CL_0002556, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008266 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008266 ] ) ] . obo:CL_2000018 obo:IAO_0000115 "Any endothelial cell of artery that is part of a coronary artery." ; terms:contributor ; oboInOwl:creation_date "2014-06-04T17:08:47Z"^^xsd:dateTime ; oboInOwl:id "CL:2000018" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "endothelial cell of coronary artery" ; rdfs:subClassOf obo:CL_0010006, obo:CL_1000413, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001621 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000413 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001621 ] ) ] . obo:CL_2000019 obo:IAO_0000115 "Any photoreceptor cell that is part of a compound eye." ; terms:contributor ; oboInOwl:creation_date "2014-06-24T23:16:45Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FBbt:00006009" ; oboInOwl:id "CL:2000019" ; a owl:Class ; rdfs:label "compound eye photoreceptor cell" ; rdfs:subClassOf obo:CL_0000287, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000018 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000210 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000018 ] ) ] . obo:CL_2000020 obo:IAO_0000115 "Any native cell that is part of a inner cell mass." ; terms:contributor ; oboInOwl:creation_date "2014-06-24T23:16:53Z"^^xsd:dateTime ; oboInOwl:id "CL:2000020" ; a owl:Class ; rdfs:label "inner cell mass cell" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000087 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000087 ] ) ] . obo:CL_2000021 obo:IAO_0000115 "Any native cell that is part of a sebaceous gland." ; terms:contributor ; terms:description """Sebaceous gland cells, also known as sebocytes, are small, oil-producing glands present in the skin of mammals. These specialized cells are predominantly located in the dermis, particularly on the face, scalp, and upper body. The primary function of sebaceous gland cells is the production and secretion of sebum, a complex mixture of lipids including triglycerides, wax esters, squalene, and metabolites of fat-soluble vitamins (such as vitamin E), as well as free fatty acids. The production process involves a unique form of programmed cell death called holocrine secretion. In this process, as sebaceous gland cells mature, they progressively accumulate lipid droplets, before ultimately disintegrating and releasing their lipid-rich contents into the gland's ductal system. The sebum generated by these cells serves multiple purposes. It acts as a waterproofing agent, preventing excessive wetting or drying of the skin and averaging skin's water-holding capacity. Sebum also has antimicrobial properties, providing a natural defense barrier against certain bacterial and fungal species. Additionally, it contributes to the skin’s suppleness and prevents it from becoming brittle. An overproduction or imbalance of sebaceous gland cells can lead to common skin disorders, such as acne, seborrhea, or rosacea, illustrating their importance in skin health. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2014-06-24T23:17:00Z"^^xsd:dateTime ; oboInOwl:id "CL:2000021" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "sebaceous gland cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000021" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001821 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001821 ] ) ] . obo:CL_2000022 obo:IAO_0000115 "Any native cell that is part of a cardiac septum." ; terms:contributor ; oboInOwl:creation_date "2014-06-24T23:17:07Z"^^xsd:dateTime ; oboInOwl:id "CL:2000022" ; a owl:Class ; rdfs:label "cardiac septum cell" ; rdfs:subClassOf obo:CL_0002494, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002099 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002099 ] ) ] . obo:CL_2000023 obo:IAO_0000115 "Any interneuron that is part of a spinal cord ventral column." ; terms:contributor ; oboInOwl:creation_date "2014-06-25T00:23:36Z"^^xsd:dateTime ; oboInOwl:id "CL:2000023" ; a owl:Class ; rdfs:label "spinal cord ventral column interneuron" ; rdfs:subClassOf obo:CL_0005000, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005375 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005375 ] ) ] . obo:CL_2000024 obo:IAO_0000115 "Any neuron that is part of a spinal cord medial motor column." ; terms:contributor ; oboInOwl:creation_date "2014-06-25T00:23:43Z"^^xsd:dateTime ; oboInOwl:id "CL:2000024" ; a owl:Class ; rdfs:label "spinal cord medial motor column neuron" ; rdfs:subClassOf obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0004059 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0004059 ] ) ] . obo:CL_2000025 obo:IAO_0000115 "Any oligodendrocyte that is part of a spinal cord." ; terms:contributor ; oboInOwl:creation_date "2014-06-25T00:23:50Z"^^xsd:dateTime ; oboInOwl:id "CL:2000025" ; a owl:Class ; rdfs:label "spinal cord oligodendrocyte" ; rdfs:subClassOf obo:CL_0000128, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000128 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:CL_2000026 obo:IAO_0000115 "Any Golgi cell that is part of a cerebellum." ; terms:contributor ; oboInOwl:creation_date "2014-06-25T00:23:57Z"^^xsd:dateTime ; oboInOwl:id "CL:2000026" ; a owl:Class ; rdfs:label "obsolete cerebellum Golgi cell" ; owl:deprecated true . obo:CL_2000027 obo:IAO_0000115 "A GABAergic inhibitory interneuron located in the molecular layer of the cerebellar cortex. It projects axons that form specialized synaptic structures around Purkinje cells, including pericellular baskets, which wrap around the Purkinje cell soma, and the pinceau: a brush-like terminal that contacts the initial segment of the Purkinje cell axon. The basket cell modulates Purkinje cell activity through both chemical (GABAergic) and non-synaptic (ephaptic) mechanisms. It is arranged in sagittal rows that align with Purkinje cell zones, contributing to the cerebellum's modular and topographically organized architecture. It plays an essential role in regulating motor coordination and potentially cognitive functions." ; terms:contributor ; oboInOwl:creation_date "2014-06-25T00:24:03Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "cerebellum basket cell" ; oboInOwl:id "CL:2000027" ; a owl:Class ; rdfs:label "cerebellar basket cell" ; rdfs:subClassOf obo:CL_0000118, obo:CL_4042035 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000118 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] ; foaf:depiction , . obo:CL_2000028 obo:IAO_0000115 "Any glutamatergic neuron that is part of a cerebellum." ; terms:contributor ; oboInOwl:creation_date "2014-06-25T00:24:10Z"^^xsd:dateTime ; oboInOwl:id "CL:2000028" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cerebellum glutamatergic neuron" ; rdfs:subClassOf obo:CL_0000679, obo:CL_1001611 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000679 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] ; skos:prefLabel "cerebellum glutamatergic neuron" . obo:CL_2000029 obo:IAO_0000115 "Any neuron that is part of a central nervous system." ; terms:contributor ; oboInOwl:creation_date "2014-06-25T01:17:43Z"^^xsd:dateTime ; oboInOwl:id "CL:2000029" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "central nervous system neuron" ; rdfs:subClassOf obo:CL_0000540, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001017 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] ; skos:prefLabel "central nervous system neuron" . obo:CL_2000030 obo:IAO_0000115 "Any native cell that is part of a hypothalamus." ; terms:contributor ; oboInOwl:creation_date "2014-06-25T01:17:50Z"^^xsd:dateTime ; oboInOwl:id "CL:2000030" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "hypothalamus cell" ; rdfs:subClassOf obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001898 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001898 ] ) ] . obo:CL_2000031 obo:IAO_0000115 "Any neuron that is part of a lateral line ganglion." ; terms:contributor ; oboInOwl:creation_date "2014-06-25T01:17:57Z"^^xsd:dateTime ; oboInOwl:id "CL:2000031" ; a owl:Class ; rdfs:label "lateral line ganglion neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000032, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_2000120 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_32443 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000032 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_2000120 ] ) ] . obo:CL_2000032 obo:IAO_0000115 "A neuron that is part of a peripheral nervous system." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2014-06-25T02:28:17Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:84664" ; oboInOwl:hasExactSynonym "PNS neuron", "peripheral neuron" ; oboInOwl:id "CL:2000032" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "peripheral nervous system neuron" ; rdfs:subClassOf obo:CL_0000540, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000010 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000010 ] ) ] . obo:CL_2000033 obo:IAO_0000115 "Any basal cell of epidermis that is part of a limb." ; terms:contributor ; oboInOwl:creation_date "2014-06-25T02:28:25Z"^^xsd:dateTime ; oboInOwl:id "CL:2000033" ; a owl:Class ; rdfs:label "limb basal cell of epidermis" ; rdfs:subClassOf obo:CL_0002187, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:CL_2000034 obo:IAO_0000115 "Any neuromast hair cell that is part of a anterior lateral line." ; terms:contributor ; oboInOwl:creation_date "2014-06-25T03:44:37Z"^^xsd:dateTime ; oboInOwl:id "CL:2000034" ; a owl:Class ; rdfs:label "anterior lateral line neuromast hair cell" ; rdfs:subClassOf obo:CL_0000856, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_2001470 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000856 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_2001470 ] ) ] . obo:CL_2000035 obo:IAO_0000115 "Any neuromast mantle cell that is part of an anterior lateral line." ; terms:contributor ; oboInOwl:creation_date "2014-06-25T03:44:44Z"^^xsd:dateTime ; oboInOwl:id "CL:2000035" ; a owl:Class ; rdfs:label "anterior lateral line neuromast mantle cell" ; rdfs:subClassOf obo:CL_0000851, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_2001470 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000851 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_2001470 ] ) ] . obo:CL_2000036 obo:IAO_0000115 "Any neuromast support cell that is part of a anterior lateral line." ; terms:contributor ; oboInOwl:creation_date "2014-06-25T03:44:51Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "anterior lateral line neuromast support cell" ; oboInOwl:id "CL:2000036" ; a owl:Class ; rdfs:label "anterior lateral line neuromast supporting cell" ; rdfs:subClassOf obo:CL_0000852, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_2001470 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000852 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_2001470 ] ) ] . obo:CL_2000037 obo:IAO_0000115 "Any neuromast hair cell that is part of a posterior lateral line." ; terms:contributor ; oboInOwl:creation_date "2014-06-25T03:44:57Z"^^xsd:dateTime ; oboInOwl:id "CL:2000037" ; a owl:Class ; rdfs:label "posterior lateral line neuromast hair cell" ; rdfs:subClassOf obo:CL_0000856, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006334 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000856 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006334 ] ) ] . obo:CL_2000038 obo:IAO_0000115 "Any neuromast mantle cell that is part of a posterior lateral line." ; terms:contributor ; oboInOwl:creation_date "2014-06-25T03:45:04Z"^^xsd:dateTime ; oboInOwl:id "CL:2000038" ; a owl:Class ; rdfs:label "posterior lateral line neuromast mantle cell" ; rdfs:subClassOf obo:CL_0000851, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006334 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000851 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006334 ] ) ] . obo:CL_2000039 obo:IAO_0000115 "Any neuromast support cell that is part of a posterior lateral line." ; terms:contributor ; oboInOwl:creation_date "2014-06-25T03:45:11Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "posterior lateral line neuromast support cell" ; oboInOwl:id "CL:2000039" ; a owl:Class ; rdfs:label "posterior lateral line neuromast supporting cell" ; rdfs:subClassOf obo:CL_0000852, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006334 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000852 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006334 ] ) ] . obo:CL_2000040 obo:IAO_0000115 "Any microvascular endothelial cell that is part of a urinary bladder." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2014-07-09T00:04:47Z"^^xsd:dateTime ; oboInOwl:id "CL:2000040" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "bladder microvascular endothelial cell" ; rdfs:subClassOf obo:CL_1001319, obo:CL_2000008 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] . obo:CL_2000041 obo:IAO_0000115 "Any dermis lymphatic vessel endothelial cell that is part of a microvascular endothelium." ; terms:contributor ; oboInOwl:creation_date "2014-07-09T00:09:54Z"^^xsd:dateTime ; oboInOwl:id "CL:2000041" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "dermis microvascular lymphatic vessel endothelial cell" ; rdfs:subClassOf obo:CL_0011030, obo:CL_2000011 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000011 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008339 ] ) ] . obo:CL_2000042 obo:IAO_0000115 "Any fibroblast that is part of a embryo." ; terms:contributor ; oboInOwl:creation_date "2014-07-09T00:12:00Z"^^xsd:dateTime ; oboInOwl:id "CL:2000042" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "embryonic fibroblast" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] ) ] . obo:CL_2000043 obo:IAO_0000115 "Any pericyte cell that is part of a brain." ; terms:contributor ; oboInOwl:creation_date "2014-07-09T00:18:22Z"^^xsd:dateTime ; oboInOwl:id "CL:2000043" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "brain pericyte" ; rdfs:subClassOf obo:CL_0002575, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000669 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:CL_2000044 obo:IAO_0000115 "Any microvascular endothelial cell that is part of a brain." ; terms:contributor ; oboInOwl:creation_date "2014-07-09T00:24:53Z"^^xsd:dateTime ; oboInOwl:id "CL:2000044" ; a owl:Class ; rdfs:label "brain microvascular endothelial cell" ; rdfs:subClassOf obo:CL_0002319, obo:CL_2000008, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:CL_2000045 obo:IAO_0000115 "Any melanocyte of skin that is part of a skin of prepuce of penis." ; terms:contributor , ; oboInOwl:creation_date "2014-07-09T00:45:07Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "melanocyte of foreskin" ; oboInOwl:id "CL:2000045" ; a owl:Class ; rdfs:label "foreskin melanocyte" ; rdfs:subClassOf obo:CL_1000458, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001471 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000458 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001471 ] ) ] . obo:CL_2000046 obo:IAO_0000115 "Any cardiac muscle cell that is part of a cardiac ventricle." ; terms:contributor ; terms:description """Ventricular cardiac muscle cells, or cardiomyocytes, are specialized cells found in the ventricular walls of the heart. They exhibit unique features, including centrally located nuclei, robust cytoskeletal structures, high mitochondria content, and intercalated discs, which contribute to their efficient pumping of blood throughout the body. The main role of ventricular cardiac muscle cells is to coordinate contractions, enabling the heart to pump blood throughout the body. This is achieved through controlled ion movement across cell membranes, generating rhythmic electrical signals called action potentials. Intercalated discs between these cells aid synchronized contractions by allowing efficient signal spread through gap junctions. The high mitochondrial content ensures a constant energy supply for this ongoing contraction cycle. Ventricular cardiac muscle cells contribute not only mechanically but also biochemically by secreting essential hormones like atrial natriuretic peptide and B-type natriuretic peptide for blood pressure regulation and cardiac remodeling. These cells exhibit low turnover under normal conditions, emphasizing their long-term stability, yet have limited regenerative capacity following cardiac injuries. Dysfunction in these cells can result in significant cardiac issues, including heart failure. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2014-08-12T20:50:28Z"^^xsd:dateTime ; oboInOwl:id "CL:2000046" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "ventricular cardiac muscle cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000046" ; rdfs:subClassOf obo:CL_0000746, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002082 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000746 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002082 ] ) ] . obo:CL_2000047 obo:IAO_0000115 "Any motor neuron that is part of a brainstem." ; terms:contributor ; oboInOwl:creation_date "2014-10-02T23:52:53Z"^^xsd:dateTime ; oboInOwl:id "CL:2000047" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "brainstem motor neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000100, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002298 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000100 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002298 ] ) ] . obo:CL_2000048 obo:IAO_0000115 "A lower motor neuron whose soma is located in the anterior horn. Anterior horn motor neurons project from the anterior portion of the grey matter in the spinal cord to some skeletal muscles." ; terms:contributor ; oboInOwl:creation_date "2014-10-03T00:26:27Z"^^xsd:dateTime ; oboInOwl:hasDbXref "NCIT:C12645" ; oboInOwl:hasExactSynonym "anterior horn cell", "ventral horn of spinal cord spinal cord motor neuron" ; oboInOwl:id "CL:2000048" ; a owl:Class ; rdfs:comment "Yang & Connolly (DOI:10.1016/B978-0-323-37101-8.00140-5) classify these as alpha motor neurons. Consider reflecting this if more references support this." ; rdfs:label "anterior horn motor neuron" ; rdfs:subClassOf obo:CL_0002612, obo:CL_0008039, obo:CL_0011001 . obo:CL_2000049 obo:IAO_0000115 "Any pyramidal cell that is part of a primary motor cortex." ; terms:contributor ; oboInOwl:creation_date "2014-10-06T17:39:04Z"^^xsd:dateTime ; oboInOwl:id "CL:2000049" ; a owl:Class ; rdfs:comment "http://www.ncbi.nlm.nih.gov/pubmed/12524689" ; rdfs:label "primary motor cortex pyramidal cell" ; rdfs:subClassOf obo:CL_4023111, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001384 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000598 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001384 ] ) ] . obo:CL_2000050 obo:IAO_0000115 "Any retinal ganglion cell that is part of a retina." ; terms:contributor ; oboInOwl:creation_date "2014-10-06T17:43:59Z"^^xsd:dateTime ; oboInOwl:id "CL:2000050" ; a owl:Class ; rdfs:comment "http://www.ncbi.nlm.nih.gov/pubmed/2889210" ; rdfs:label "obsolete retina retinal ganglion cell" ; owl:deprecated true . obo:CL_2000051 obo:IAO_0000115 "Any fibroblast that is part of a spleen." ; terms:contributor ; oboInOwl:creation_date "2014-10-06T18:58:47Z"^^xsd:dateTime ; oboInOwl:id "CL:2000051" ; a owl:Class ; rdfs:label "splenic fibroblast" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] . obo:CL_2000052 obo:IAO_0000115 "Any endothelial cell of artery that is part of a umbilical cord." ; terms:contributor ; oboInOwl:creation_date "2014-10-06T19:01:48Z"^^xsd:dateTime ; oboInOwl:id "CL:2000052" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=8010" ; rdfs:label "umbilical artery endothelial cell" ; rdfs:subClassOf obo:CL_0000349, obo:CL_1000413, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002331 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000413 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002331 ] ) ] . obo:CL_2000053 obo:IAO_0000115 "Any endothelial cell that is part of a spleen." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2014-10-06T19:06:04Z"^^xsd:dateTime ; oboInOwl:id "CL:2000053" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=5500" ; rdfs:label "splenic endothelial cell" ; rdfs:subClassOf obo:CL_0000115, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-white-pulp/v1.2/assets/2d-ftu-spleen-white-pulp.png" . obo:CL_2000054 obo:IAO_0000115 "A large, granular, liver specific natural killer cell that adheres to the endothelial cells of the hepatic sinusoid." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Pit cells are named for the presence of large cytoplasmic granules that resemble pits (pips) of fruit." ; rdfs:label "hepatic pit cell" ; rdfs:subClassOf obo:CL_4047101 . obo:CL_2000055 obo:IAO_0000115 "Any dendritic cell that is part of a liver." ; terms:contributor ; oboInOwl:creation_date "2014-10-06T19:16:11Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "hepatic dendritic cell" ; oboInOwl:id "CL:2000055" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "http://www.jleukbio.org/content/66/2/322.abstract" ; rdfs:label "liver dendritic cell" ; rdfs:subClassOf obo:CL_0000451, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000451 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:CL_2000056 obo:IAO_0000115 "Any pyramidal cell that is part of a regional part of cerebral cortex." ; terms:contributor ; oboInOwl:creation_date "2014-10-06T19:20:41Z"^^xsd:dateTime ; oboInOwl:id "CL:2000056" ; a owl:Class ; rdfs:label "Meynert cell" ; rdfs:subClassOf obo:CL_2000049 . obo:CL_2000057 obo:IAO_0000115 "Any osteoblast that is part of a femur." ; terms:contributor ; oboInOwl:creation_date "2014-10-06T19:29:45Z"^^xsd:dateTime ; oboInOwl:id "CL:2000057" ; a owl:Class ; rdfs:label "femoral osteoblast" ; rdfs:subClassOf obo:CL_0000062, obo:CL_0001035, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000981 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000981 ] ) ] . obo:CL_2000058 obo:IAO_0000115 "Any osteoblast that is part of a skull." ; terms:contributor ; oboInOwl:creation_date "2014-10-06T19:48:30Z"^^xsd:dateTime ; oboInOwl:id "CL:2000058" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=4600" ; rdfs:label "calvarial osteoblast" ; rdfs:subClassOf obo:CL_0000062, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003129 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003129 ] ) ] . obo:CL_2000059 obo:IAO_0000115 "Any microvascular endothelial cell that is part of a prostate gland." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2014-10-07T17:46:27Z"^^xsd:dateTime ; oboInOwl:id "CL:2000059" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=4400" ; rdfs:label "prostate gland microvascular endothelial cell" ; rdfs:subClassOf obo:CL_2000008, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" . obo:CL_2000060 obo:IAO_0000115 "A trophoblast of placental villi. These cells fuse to form synctial trophoplast - the placental side of the interface between the placenta and maternal blood sinusoids in the decidua." ; terms:contributor ; terms:description """The placental villous trophoblast, a highly specialized cell type crucial for placental development, plays a key role in facilitating exchanges between the maternal bloodstream and the developing fetus. Structurally, placental villous trophoblasts are situated on the villous tree structures, forming an outer epithelial layer. Comprising two subtypes—proliferating cytotrophoblasts forming the inner layer and terminally differentiated syncytiotrophoblasts constituting the outer layer in contact with maternal blood—these cells define the placental architecture. Functionally, placental villous trophoblasts play pivotal roles in forming and maintaining the placenta, ensuring the safe development of the fetus. Their primary function involves managing substance exchange between the mother and fetus, mediating the transfer of gases, nutrients, hormones, and waste materials to support optimal fetal growth. Additionally, these trophoblasts synthesize and release crucial hormones like human chorionic gonadotropin (hCG), which maintains the decidua and signals the mother's body to sustain pregnancy. Acting as a physical and immunological barrier, they protect the fetus from maternal immune cells and prevent the transmission of pathogens, contributing significantly to the success of pregnancy. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:creation_date "2014-10-07T17:48:27Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0006119", "BTO:0006208" ; oboInOwl:hasExactSynonym "vCTB", "villous cytotrophoblast" ; oboInOwl:id "CL:2000060" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Same as synctial trophoblast?" ; rdfs:label "placental villous trophoblast" ; rdfs:seeAlso "http://www.sciencellonline.com/site/productInformation.php?keyword=7120", "https://cellxgene.cziscience.com/cellguide/CL_2000060" ; rdfs:subClassOf obo:CL_0000351, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010005 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000351 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010005 ] ) ] . obo:CL_2000061 obo:IAO_0000115 "Any mesenchymal stem cell that is part of a placenta." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2014-10-07T17:51:11Z"^^xsd:dateTime ; oboInOwl:id "CL:2000061" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=7140" ; rdfs:label "placental amniotic mesenchymal stromal cell" ; rdfs:subClassOf obo:CL_0000134, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:CL_2000062 obo:IAO_0000115 "Any capillary endothelial cell that is part of a placenta." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2014-10-07T17:55:56Z"^^xsd:dateTime ; oboInOwl:id "CL:2000062" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "http://www.ncbi.nlm.nih.gov/books/NBK53245/" ; rdfs:label "placental villus capillary endothelial cell" ; rdfs:subClassOf obo:CL_0002144, obo:CL_0009092 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002144 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:CL_2000063 obo:IAO_0000115 "Any fibroblast that is part of a female gonad." ; terms:contributor ; oboInOwl:creation_date "2014-10-07T17:57:42Z"^^xsd:dateTime ; oboInOwl:id "CL:2000063" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=7330" ; rdfs:label "ovarian fibroblast" ; rdfs:subClassOf obo:CL_0000057, obo:CL_0002132 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] . obo:CL_2000064 obo:IAO_0000115 "A meso-epithelial cell of the ovarian surface epithelium, varying in shape from flat to cuboidal to pseudostratified columnar. This cell plays a crucial role in ovulation by producing proteolytic enzymes in response to gonadotropins, facilitating follicle rupture through tissue breakdown and TNF-alpha signaling. Additionally, this cell contributes to post-ovulatory wound repair (Morris et al., 2022) and exhibits stem cell-like properties (Flesken-Nikitin et al., 2013; Wang et al., 2019)." ; terms:contributor ; oboInOwl:creation_date "2014-10-07T17:59:13Z"^^xsd:dateTime ; oboInOwl:id "CL:2000064" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "ovarian surface epithelial cell" ; rdfs:subClassOf obo:CL_0002078, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001304 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002078 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001304 ] ) ] . obo:CL_2000065 obo:IAO_0000115 "Any microvascular endothelial cell that is part of a female urethra." ; terms:contributor ; oboInOwl:creation_date "2014-10-07T18:18:01Z"^^xsd:dateTime ; oboInOwl:id "CL:2000065" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=7300" ; rdfs:label "ovarian microvascular endothelial cell" ; rdfs:subClassOf obo:CL_1001320, obo:CL_2000008, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001334 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001334 ] ) ] . obo:CL_2000066 obo:IAO_0000115 "Any fibroblast that is part of a cardiac ventricle." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2014-10-07T18:35:38Z"^^xsd:dateTime ; oboInOwl:id "CL:2000066" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=6310" ; rdfs:label "cardiac ventricle fibroblast" ; rdfs:subClassOf obo:CL_0002548, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002082 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002082 ] ) ] . obo:CL_2000067 obo:IAO_0000115 "Any fibroblast that is part of a cardiac atrium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2014-10-07T18:36:54Z"^^xsd:dateTime ; oboInOwl:id "CL:2000067" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=6320" ; rdfs:label "cardiac atrium fibroblast" ; rdfs:subClassOf obo:CL_0002548, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002081 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002081 ] ) ] . obo:CL_2000068 obo:IAO_0000115 "Any fibroblast that is part of a pericardium." ; terms:contributor ; oboInOwl:creation_date "2014-10-07T18:38:06Z"^^xsd:dateTime ; oboInOwl:id "CL:2000068" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=6430" ; rdfs:label "pericardium fibroblast" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002407 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002407 ] ) ] . obo:CL_2000069 obo:IAO_0000115 "Any fibroblast that is part of a gallbladder." ; terms:contributor ; oboInOwl:creation_date "2014-10-07T18:41:43Z"^^xsd:dateTime ; oboInOwl:id "CL:2000069" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=5430" ; rdfs:label "gallbladder fibroblast" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002110 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002110 ] ) ] . obo:CL_2000070 obo:IAO_0000115 "Any fibroblast that is part of a optic choroid." ; terms:contributor ; oboInOwl:creation_date "2014-10-07T18:50:43Z"^^xsd:dateTime ; oboInOwl:id "CL:2000070" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=6620" ; rdfs:label "optic choroid fibroblast" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001776 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001776 ] ) ] . obo:CL_2000071 obo:IAO_0000115 "Any microvascular endothelial cell that is part of a breast." ; terms:contributor ; oboInOwl:creation_date "2014-10-07T19:55:30Z"^^xsd:dateTime ; oboInOwl:id "CL:2000071" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=7600" ; rdfs:label "mammary microvascular endothelial cell" ; rdfs:subClassOf obo:CL_2000008, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000310 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000310 ] ) ] . obo:CL_2000072 obo:IAO_0000115 "Any microvascular endothelial cell that is part of a adipose tissue." ; terms:contributor ; oboInOwl:creation_date "2014-10-07T22:13:45Z"^^xsd:dateTime ; oboInOwl:id "CL:2000072" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=7200" ; rdfs:label "adipose microvascular endothelial cell" ; rdfs:subClassOf obo:CL_0002320, obo:CL_2000008, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001013 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001013 ] ) ] . obo:CL_2000073 obo:IAO_0000115 "Any migratory neural crest cell that is part of a cardiac neural crest." ; terms:contributor ; oboInOwl:creation_date "2014-11-05T01:18:43Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "cardiac neural crest cell" ; oboInOwl:id "CL:2000073" ; a owl:Class ; rdfs:label "migratory cardiac neural crest cell" ; rdfs:subClassOf obo:CL_0000333, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000095 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000333 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000095 ] ) ] . obo:CL_2000074 obo:IAO_0000115 "Any leukocyte that is part of a spleen." ; terms:contributor ; oboInOwl:creation_date "2014-11-05T01:26:50Z"^^xsd:dateTime ; oboInOwl:id "CL:2000074" ; a owl:Class ; rdfs:comment "Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology." ; rdfs:label "splenocyte" ; rdfs:subClassOf obo:CL_0000738, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000738 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] . obo:CL_2000075 obo:IAO_0000115 "Any endodermal cell that is part of a anterior visceral endoderm." ; terms:contributor ; oboInOwl:creation_date "2014-11-05T01:34:13Z"^^xsd:dateTime ; oboInOwl:id "CL:2000075" ; a owl:Class ; rdfs:label "anterior visceral endoderm cell" ; rdfs:subClassOf obo:CL_0000223, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004044 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000223 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004044 ] ) ] . obo:CL_2000076 obo:IAO_0000115 "Any vein endothelial cell that is part of a hindlimb stylopod." ; terms:contributor ; oboInOwl:creation_date "2014-12-02T18:40:47Z"^^xsd:dateTime ; oboInOwl:id "CL:2000076" ; a owl:Class ; rdfs:label "hindlimb stylopod vein endothelial cell" ; rdfs:subClassOf obo:CL_0002543, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002543 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 ] ) ] . obo:CL_2000077 obo:IAO_0000115 "Any striated muscle cell that is part of a skeletal muscle tissue of pectoralis major." ; terms:contributor ; oboInOwl:creation_date "2014-12-02T18:48:17Z"^^xsd:dateTime ; oboInOwl:id "CL:2000077" ; a owl:Class ; rdfs:label "skeletal muscle tissue of pectoralis major striated muscle cell" ; rdfs:subClassOf obo:CL_0000188, obo:CL_0000737, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004510 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000737 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004510 ] ) ] . obo:CL_2000078 obo:IAO_0000115 "Any pericyte cell that is part of a placenta." ; terms:contributor ; oboInOwl:creation_date "2014-12-02T18:51:03Z"^^xsd:dateTime ; oboInOwl:id "CL:2000078" ; a owl:Class ; rdfs:label "placental pericyte" ; rdfs:subClassOf obo:CL_0000669, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000669 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:CL_2000079 obo:IAO_0000115 "Any mesenchymal stem cell of the bone marrow that is part of a femur." ; terms:contributor ; oboInOwl:creation_date "2014-12-02T19:07:31Z"^^xsd:dateTime ; oboInOwl:id "CL:2000079" ; a owl:Class ; rdfs:label "mesenchymal stem cell of femoral bone marrow" ; rdfs:subClassOf obo:CL_0002540, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000981 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002540 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000981 ] ) ] . obo:CL_2000080 obo:IAO_0000115 "Any mesenchymal stem cell of adipose tissue that is part of an abdomen." ; terms:contributor ; oboInOwl:creation_date "2014-12-02T19:10:34Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "mesenchymal stem cell of abdominal adipose" ; oboInOwl:id "CL:2000080" ; a owl:Class ; rdfs:label "mesenchymal stem cell of abdominal adipose tissue" ; rdfs:subClassOf obo:CL_0002570, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002570 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:CL_2000081 obo:IAO_0000115 "Any melanocyte of skin that is part of a skin of face." ; terms:contributor ; oboInOwl:creation_date "2014-12-02T19:10:40Z"^^xsd:dateTime ; oboInOwl:id "CL:2000081" ; a owl:Class ; rdfs:label "melanocyte of skin of face" ; rdfs:subClassOf obo:CL_1000458, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_1000021 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000458 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_1000021 ] ) ] . obo:CL_2000082 obo:IAO_0000115 "OBSOLETE. Any melanocyte of skin that is part of a skin of prepuce of penis." ; obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_2000045 ; terms:contributor ; oboInOwl:creation_date "2014-12-02T19:10:45Z"^^xsd:dateTime ; oboInOwl:id "CL:2000082" ; a owl:Class ; rdfs:comment "Term was merged into foreskin melanocyte CL_2000045" ; rdfs:label "obsolete melanocyte of foreskin" ; owl:deprecated true . obo:CL_2000083 obo:IAO_0000115 "Any hair follicle dermal papilla cell that is part of a scalp." ; terms:contributor ; oboInOwl:creation_date "2014-12-02T19:10:50Z"^^xsd:dateTime ; oboInOwl:id "CL:2000083" ; a owl:Class ; rdfs:label "hair follicle dermal papilla cell of scalp" ; rdfs:subClassOf obo:CL_0000346, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000403 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000346 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000403 ] ) ] . obo:CL_2000084 obo:IAO_0000115 "A goblet cell that is part of the conjunctival epithelium, characterized by apical accumulation of mucin granules (containing MUC5AC in humans; Muc5ac/Muc5b in mice). These gel-forming mucins support tear film stability, ocular lubrication, and pathogen defence. The conjunctival goblet cell forms tight junctions with neighbouring epithelial cells via species-specific claudins (claudin-10 in humans, claudin-2 in mice) and regulates immune homeostasis by facilitating soluble antigen transport to dendritic cells through goblet cell-associated antigen passages (GAPs) (Barbosa et al., 2017). The transcription factor SPDEF is essential for its differentiation." ; terms:contributor ; oboInOwl:creation_date "2014-12-02T19:28:38Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "CGC" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "conjunctiva goblet cell" ; rdfs:subClassOf obo:CL_0000160, obo:CL_1000432, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006763 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006763 ] ) ] . obo:CL_2000085 obo:IAO_0000115 "Any mononuclear cell that is part of a umbilical cord." ; terms:contributor ; oboInOwl:creation_date "2014-12-02T20:14:16Z"^^xsd:dateTime ; oboInOwl:id "CL:2000085" ; a owl:Class ; rdfs:label "mononuclear cell of umbilical cord" ; rdfs:subClassOf obo:CL_0000349, obo:CL_0000842, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002331 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002331 ] ) ] . obo:CL_2000086 obo:IAO_0000115 "Any basket cell that is part of a neocortex." ; terms:contributor ; oboInOwl:creation_date "2014-12-24T00:37:19Z"^^xsd:dateTime ; oboInOwl:id "CL:2000086" ; a owl:Class ; rdfs:label "neocortex basket cell" ; rdfs:subClassOf obo:CL_0000118, obo:CL_0010011, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001950 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000118 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001950 ] ) ] . obo:CL_2000087 obo:IAO_0000115 "Any basket cell that is part of a dentate gyrus of hippocampal formation." ; terms:contributor ; oboInOwl:creation_date "2014-12-24T00:37:24Z"^^xsd:dateTime ; oboInOwl:id "CL:2000087" ; a owl:Class ; rdfs:label "dentate gyrus of hippocampal formation basket cell" ; rdfs:subClassOf obo:CL_0000118, obo:CL_0010011, obo:CL_1001569, obo:CL_4023062 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000118 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001885 ] ) ] . obo:CL_2000088 obo:IAO_0000115 "Any basket cell that is part of a Ammon's horn." ; terms:contributor ; oboInOwl:creation_date "2014-12-24T00:37:30Z"^^xsd:dateTime ; oboInOwl:id "CL:2000088" ; a owl:Class ; rdfs:label "Ammon's horn basket cell" ; rdfs:subClassOf obo:CL_0000118, obo:CL_0010011, obo:CL_1001569, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001954 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000118 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001954 ] ) ] . obo:CL_2000089 obo:IAO_0000115 "A granule cell that has soma location in the dentate gyrus cell layer of the hippocampal formation and has an elliptical cell body and characteristic cone-shaped tree of spiny apical dendrites. The branches extend throughout the molecular layer and the distal tips of the dendritic tree end just at the hippocampal fissure or at the ventricular surface. The dentate gyrus granule cell is the principal cell type of the dentate gyrus." ; terms:contributor ; oboInOwl:creation_date "2015-02-23T05:48:23Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "dentate gyrus of hippocampal formation granule cell" ; oboInOwl:id "CL:2000089" ; a owl:Class ; rdfs:comment "As far as can be determined, all dentate granule cells appear to project to CA3 and the axon trajectory is partially correlated with the position of the parent cell body." ; rdfs:label "dentate gyrus granule cell" ; rdfs:subClassOf obo:CL_0001033, obo:CL_4023062, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005381 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001033 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005381 ] ) ] ; skos:prefLabel "dentate gyrus granule cell" . obo:CL_2000090 obo:IAO_0000115 "Any stellate cell that is part of a dentate gyrus of hippocampal formation." ; terms:contributor ; oboInOwl:creation_date "2015-02-23T05:48:40Z"^^xsd:dateTime ; oboInOwl:id "CL:2000090" ; a owl:Class ; rdfs:label "dentate gyrus of hippocampal formation stellate cell" ; rdfs:subClassOf obo:CL_0000122, obo:CL_4023062 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000122 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001885 ] ) ] . obo:CL_2000091 obo:IAO_0000115 "Any microvascular endothelial cell that is part of a endometrial blood vessel." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2015-03-31T21:02:36Z"^^xsd:dateTime ; oboInOwl:id "CL:2000091" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "endometrial microvascular endothelial cell" ; rdfs:subClassOf obo:CL_0009095, obo:CL_2000008, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0015172 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0015172 ] ) ] . obo:CL_2000092 obo:IAO_0000115 "Any keratinocyte that is part of a hair follicle." ; terms:contributor ; oboInOwl:creation_date "2015-03-31T21:07:02Z"^^xsd:dateTime ; oboInOwl:id "CL:2000092" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "hair follicular keratinocyte" ; rdfs:subClassOf obo:CL_0002559, obo:CL_4052061 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000312 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002073 ] ) ] . obo:CL_2000093 obo:IAO_0000115 "Any fibroblast of lung that is part of a bronchus." ; terms:contributor ; oboInOwl:creation_date "2015-03-31T21:16:22Z"^^xsd:dateTime ; oboInOwl:id "CL:2000093" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "bronchus fibroblast of lung" ; rdfs:subClassOf obo:CL_0002553, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002553 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:CL_2000094 obo:IAO_0000115 "Any epithelial cell of viscerocranial mucosa that is part of a nasal cavity respiratory epithelium." ; terms:contributor ; oboInOwl:creation_date "2015-03-31T22:25:17Z"^^xsd:dateTime ; oboInOwl:id "CL:2000094" ; a owl:Class ; rdfs:label "nasal cavity respiratory epithelium epithelial cell of viscerocranial mucosa" ; rdfs:subClassOf obo:CL_0002631, obo:CL_1000441, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005385 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000441 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005385 ] ) ] . obo:CL_2000095 obo:IAO_0000115 "Any hematopoietic stem cell that is part of a umbilical cord blood." ; terms:contributor ; oboInOwl:creation_date "2015-05-26T18:58:34Z"^^xsd:dateTime ; oboInOwl:id "CL:2000095" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cord blood hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0002246, obo:CL_0002352, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012168 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012168 ] ) ] . obo:CL_2000096 obo:IAO_0000115 "Any fibroblast that is part of a reticular layer of dermis." ; terms:contributor ; oboInOwl:creation_date "2015-08-11T16:28:16Z"^^xsd:dateTime ; oboInOwl:id "CL:2000096" ; a owl:Class ; rdfs:label "fibroblast of the reticular layer of dermis" ; rdfs:subClassOf obo:CL_0002551, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001993 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001993 ] ) ] . obo:CL_2000097 obo:IAO_0000115 "Any dopaminergic neuron that is part of a midbrain." ; terms:contributor ; oboInOwl:creation_date "2015-12-03T16:42:40Z"^^xsd:dateTime ; oboInOwl:id "CL:2000097" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "midbrain dopaminergic neuron" ; rdfs:subClassOf obo:CL_0000700, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001891 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000700 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001891 ] ) ] . obo:CL_3000000 obo:IAO_0000115 "A ciliated epithelial cell of the esophagus." ; terms:contributor ; oboInOwl:creation_date "2019-02-09T16:40:30Z"^^xsd:dateTime ; oboInOwl:id "CL:3000000" ; a owl:Class ; rdfs:label "ciliated epithelial cell of esophagus" ; rdfs:subClassOf obo:CL_0002252 . obo:CL_3000001 obo:IAO_0000115 "A tissue-resident macrophage that is part of the placenta. A Hofbauer cell expresses high levels of growth factors and metalloproteinases that support vasculogenesis, angiogenesis, branching morphogenesis and tissue remodeling. A Hofbauer cell has a fetal origin, is found in the villous stroma, chorion, and amnion, and is present throughout pregnancy." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; oboInOwl:creation_date "2019-02-18T19:41:20Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "fetal Hofbauer cell" ; oboInOwl:hasRelatedSynonym "HBC" ; oboInOwl:id "CL:3000001" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Hofbauer cells are a heterogenic group of macrophages that resemble M2-like cells. Initially described in chorionic villi in humans, a Hofbauer cell is now often used to describe any fetal-derived placental macrophage that resides within the placental villous core, amnion, and chorion laeve." ; rdfs:label "Hofbauer cell" ; rdfs:subClassOf obo:CL_4033087 . obo:CL_3000002 obo:IAO_0000115 "Sympathetic noradrenergic neuron." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2019-02-25T19:30:14Z"^^xsd:dateTime ; oboInOwl:id "CL:3000002" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "sympathetic noradrenergic neuron" ; rdfs:subClassOf obo:CL_0008025, obo:CL_0011103 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011103 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061533 ] ) ] . obo:CL_3000003 obo:IAO_0000115 "A type of autonomic neuron that releases acetylcholine." ; terms:contributor ; oboInOwl:creation_date "2019-02-25T19:32:20Z"^^xsd:dateTime ; oboInOwl:id "CL:3000003" ; a owl:Class ; rdfs:label "sympathetic cholinergic neuron" ; rdfs:subClassOf obo:CL_0000108, obo:CL_0011103 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011103 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0014055 ] ) ] . obo:CL_3000004 obo:IAO_0000115 "A neuron type that is located in a peripheral nervous system and it transmits sensory information from the peripheral (PNS) to the central nervous system (CNS). A sensory neuron converts physical (light, sound, touch) or chemical (such as taste and smell) stimuli into an electrical signal through a process known as sensory transduction. The function of a sensory neuron is to carry informations from the external environment and internal body conditions to the central nervous system for further processing." ; terms:contributor ; oboInOwl:creation_date "2019-02-25T19:34:33Z"^^xsd:dateTime ; oboInOwl:id "CL:3000004" ; a owl:Class ; rdfs:comment "Typically, a sensory neuron has a pseudounipolar morphology." ; rdfs:label "peripheral sensory neuron" ; rdfs:subClassOf obo:CL_0000101, obo:CL_2000032 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000032 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050906 ] ) ] . obo:CL_4006000 obo:IAO_0000115 "A fibroblast that is part of the breast." ; terms:contributor ; oboInOwl:hasExactSynonym "breast fibroblast" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "fibroblast of breast" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000310 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000310 ] ) ] . obo:CL_4006001 obo:IAO_0000115 "A fibroblast that is part of the skin of scalp." ; terms:contributor ; oboInOwl:hasExactSynonym "skin of scalp fibroblast" ; a owl:Class ; rdfs:label "fibroblast of skin of scalp" ; rdfs:subClassOf obo:CL_0002620, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8300000 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8300000 ] ) ] . obo:CL_4023000 obo:IAO_0000115 "A motor neuron that innervates both intrafusal and extrafusal muscle fibers. Low abundancy. They control both muscle contraction and responsiveness of the sensory feedback from muscle spindles." ; terms:contributor ; a owl:Class ; rdfs:label "beta motor neuron" ; rdfs:subClassOf obo:CL_0008039, [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_0008046 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_0008047 ] . obo:CL_4023001 obo:IAO_0000115 "A beta motor neuron that innervates nuclear chain fibers." ; terms:contributor ; a owl:Class ; rdfs:label "static beta motor neuron" ; rdfs:subClassOf obo:CL_4023000 . obo:CL_4023002 obo:IAO_0000115 "A beta motor neuron that innervates the nuclear bag fibers of muscle spindles." ; terms:contributor ; a owl:Class ; rdfs:label "dynamic beta motor neuron" ; rdfs:subClassOf obo:CL_4023000 . obo:CL_4023003 obo:IAO_0000115 "A type of intrafusal muscle fiber that has nuclei arranged in a linear row. Unlike nuclear bag fibers, the equatorial region of these fibers (in the centre of the spindle) is not expanded. These fibers are responsible for the detection of changes in muscle length. They are innervated by static gamma motor neurons and are principally associated with type II sensory fibers." ; terms:contributor ; a owl:Class ; rdfs:label "nuclear chain fiber" ; rdfs:subClassOf obo:CL_0008047 . obo:CL_4023004 obo:IAO_0000115 "A type of intrafusal muscle fiber that lies in the center of a muscle spindle. Nuclei are clustered centrally and give the equatorial region a swollen appearance. They are associated with associated with dynamic gamma motor neurons, and the stretching of the equatorial region of the nuclear bag fibers results in an increase in the firing rate of type Ia sensory fibers." ; terms:contributor ; a owl:Class ; rdfs:label "nuclear bag fiber" ; rdfs:subClassOf obo:CL_0008047 . obo:CL_4023005 obo:IAO_0000115 "A nuclear bag fiber that is sensitive mainly to the rate of change in muscle length." ; terms:contributor ; oboInOwl:hasExactSynonym "bag1 fiber", "nuclear bag1 intrafusal fiber" ; a owl:Class ; rdfs:label "dynamic nuclear bag fiber" ; rdfs:subClassOf obo:CL_4023004 . obo:CL_4023006 obo:IAO_0000115 "A nuclear bag fiber that is sensitive only changes in muscle length but not the rate of that change." ; terms:contributor ; oboInOwl:hasExactSynonym "bag2 fiber", "nuclear bag2 intrafusal fiber" ; a owl:Class ; rdfs:label "static nuclear bag fiber" ; rdfs:subClassOf obo:CL_4023004 . obo:CL_4023007 obo:IAO_0000028 "L2/3 bipolar VIP interneuron (Mus)" ; obo:IAO_0000115 "A VIP GABAergic cortical interneuron with bipolar morphology, with a soma found in L2/3. L2/3 bipolar VIP cells have extending axons across all layers (with preferences for layers II/III and Va) and a dendritic tree that is vertically more restricted than deeper layer VIP cells and extend fewer dendrites into the layers outside their home layer (location of soma). L2/3 bipolar VIP cells have great variability in firing patterns, though most are continuous adapting. L2/3 bipolar VIP cells are more depolarized in their resting state, had less fast rectification, and had smaller after hyperpolarization than deeper VIP cells." ; terms:contributor ; oboInOwl:hasExactSynonym "L2/3 bipolar Vip (Mus musculus)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "L2/3 bipolar VIP GABAergic interneuron (Mmus)" ; rdfs:subClassOf obo:CL_0000103, obo:CL_4023016, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8440000 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_P32648 ] . obo:CL_4023008 obo:IAO_0000028 "IT neuron" ; obo:IAO_0000115 "A glutamatergic neuron located in the cerebral cortex that projects to structures of telencephalic origins." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770100" ; oboInOwl:hasExactSynonym "IT neuron" ; oboInOwl:inSubset cl:BDS_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "intratelencephalic-projecting glutamatergic cortical neuron" ; rdfs:subClassOf obo:CL_0000679, obo:CL_0010012, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070034 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000679 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070034 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] . obo:CL_4023009 obo:IAO_0000028 "ET glut" ; obo:IAO_0000115 "A glutamatergic neuron located in the cerebral cortex that projects to structures not derived from telencephalon." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770101" ; oboInOwl:hasExactSynonym "ET projecting neuron" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "extratelencephalic-projecting glutamatergic cortical neuron" ; rdfs:subClassOf obo:CL_0000679, obo:CL_0010012, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070028 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000679 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070028 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] . obo:CL_4023010 obo:IAO_0000028 "A7 interneuron" ; obo:IAO_0000115 "A GABAergic cortical interneuron that is strongly labelled for α7 nAChRs. These cells have soma found in L1 and have multipolar dendrites with vertically descending axonal collaterals that project deep into the column, usually branching and terminating in L5A." ; terms:contributor ; oboInOwl:hasExactSynonym "A7 cell (Mus musculus)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:comment "Unlike typical Lamp5 electrophysiology, A7 cells have Vip- and Sst-like firing properties, with active depolarizing hump at near-threshold membrane potentials, and larger hyperpolarization sag, stronger burst, and rebound firing. A7 cells have a transcriptomics signature that looks like Lamp5 GABAergic interneuron." ; rdfs:label "alpha7 GABAergic cortical interneuron (Mmus)" ; rdfs:subClassOf obo:CL_0010011, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000005460 ] . obo:CL_4023011 obo:IAO_0000028 "Lamp5 cortical interneuron" ; obo:IAO_0000115 "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Lamp5. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Lamp5." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770149" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:comment "The marker set LINC00298, KIT can identify the Human cell type lamp5 GABAergic cortical interneuron in the neocortex with a confidence of 0.814687838 (NS-Forest FBeta value)." ; rdfs:label "lamp5 GABAergic cortical interneuron" ; rdfs:subClassOf obo:CL_4023064, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000032148 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000074 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000032148 ] ) ] . obo:CL_4023012 obo:IAO_0000028 "NP glut neuron" ; obo:IAO_0000115 "A glutamatergic neuron located in the cerebral cortex that projects axons locally rather than distantly." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770103" ; oboInOwl:hasExactSynonym "NP neuron" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "near-projecting glutamatergic cortical neuron" ; rdfs:subClassOf obo:CL_0000679, obo:CL_0010012, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070030 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000679 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070030 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] . obo:CL_4023013 obo:IAO_0000028 "CT glut" ; obo:IAO_0000115 "A glutamatergic neuron located in the cerebral cortex that projects to the thalamus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasExactSynonym "CT projecting neuron" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "corticothalamic-projecting glutamatergic cortical neuron" ; rdfs:subClassOf obo:CL_0000679, obo:CL_0010012, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070029 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000679 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070029 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] . obo:CL_4023014 obo:IAO_0000028 "L5 VIP interneuron (Mus)" ; obo:IAO_0000115 "A VIP GABAergic cortical interneuron with a soma found in L5. L5 VIP cells have mostly local morphology with some deep-projecting axons. They show only moderate resistance, comparable to that of sst subclass and unlike typical VIP subclass cells that tend to show high input resistance. L5 VIP cells show particularly low resting membrane potential." ; terms:contributor ; oboInOwl:hasExactSynonym "L5 VIP (Mus musculus)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "L5 VIP GABAergic interneuron (Mmus)" ; rdfs:subClassOf obo:CL_4023016, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005394 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_P32648 ] . obo:CL_4023015 obo:IAO_0000028 "sncg cortical interneuron" ; obo:IAO_0000115 "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Gamma-synuclein. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Sncg." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770150" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:comment "The marker set RXRG, THSD7B can identify the Human cell type sncg GABAergic cortical interneuron in the neocortex with a confidence of 0.628943702 (NS-Forest FBeta value)." ; rdfs:label "sncg GABAergic cortical interneuron" ; rdfs:subClassOf obo:CL_4023064, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000015325 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000081 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000015325 ] ) ] . obo:CL_4023016 obo:IAO_0000028 "VIP cortical interneuron" ; obo:IAO_0000115 "A transcriptomically distinct cortical GABAergic neuron that expresses the vasocactive intestinal polypeptide and that has its soma located in the cerebral cortex. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Vip." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:description "This neuronal type is distinguished by its heterogeneous morphology and electrophysiological characteristics (Pronneke et al., 2015,2020; Apicella and Marchionni, 2022). Variations in morphology and firing patterns are observed in human cortical VIP interneurons. In a study by Lee et al., 2023, four distinct subtypes of VIP neurons were identified, each exhibiting unique morphologies, soma locations, and electrophysiological properties. These subtypes are defined according to their transcriptomic markers: LBH-VIP and CCD184-VIP, both of which display a bipolar morphology with axons and dendrites extending across cortical layers; and SY16-VIP and ADAMTSL1-VIP, characterized by a dendritic arbor that spreads horizontally within the same layer as the soma (Lee et al., 2023). Disruption or malfunction of VIP cortical interneuron is implicated in neurodevelopmental disorders such as Rett Syndrome and Dravet Syndrome (Goff and Goldberg 2021)." ; oboInOwl:hasBroadSynonym "VIP interneuron", "VIP neuron", "VIP-Expressing GABAergic Neuron", "Vip GABAergic neuron" ; oboInOwl:hasDbXref "ILX:0770151" ; oboInOwl:hasRelatedSynonym "VIP type", "VIP-IN", "Vip", "cortical VIP neuron" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:comment "The marker set VIP can identify the Human cell type VIP GABAergic cortical interneuron in the neocortex with a confidence of 0.855531344 (NS-Forest FBeta value)." ; rdfs:label "VIP GABAergic cortical interneuron" ; rdfs:subClassOf obo:CL_4023064, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017299 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000085 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017299 ] ) ] . obo:CL_4023017 obo:IAO_0000028 "sst cortical interneuron" ; obo:IAO_0000115 "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses somatostatin (sst). The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Sst." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770152" ; oboInOwl:hasRelatedSynonym "SOM+ inhibitory interneuron", "SST+ IN", "somatostatin-expressing inhibitory interneuron" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:comment "In the mouse cortex, sst GABAergic cortical interneurons show heterogeneous electrophysiological signatures varying between low-threshold spiking (LTS), regular-spiking and fast-spiking (Song, Y. H., Yoon, J., & Lee, S. H. 2021). Sst GABAergic cortical interneurons have multiple functional roles in the brain. In the mouse, they involved in the generation of slow-waves during the sleep phase of non-rapid eye-movement (NREM) (Funk, C. M. et al., 2017), they maintain synaptic plasticity during motor learning (Adler, A., Zhao, R., et al., 2021), they enhance visual perception in the V1 cortical area by suppressing the activity of pyramidal excitatory neurons (Song, YH. et al., 2020). In humans, malfunctioning of sst GABAergic cortical interneurons is associated with neurodegenerative and psychiatric disorders such as Parkinson's disease, Alzheimer's disease, major depressive disorder, bipolar disorder and schizophrenia as individuals affected by these pathologies show a decrease of expression of SST in the brain (Song YH., Yoon J. et al., 2021).", "The marker set SST, PLCH1 can identify the Human cell type sst GABAergic cortical interneuron in the neocortex with a confidence of 0.842367005 (NS-Forest FBeta value)." ; rdfs:label "sst GABAergic cortical interneuron" ; rdfs:subClassOf obo:CL_4023069, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000015665 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000082 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023069 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000015665 ] ) ] . obo:CL_4023018 obo:IAO_0000028 "pvalb cortical interneuron" ; obo:IAO_0000115 "A transcriptomically distinct GABAergic interneuron with a soma located in a cerebral cortex and it expresses Parvalbumin. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Pvalb." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770154" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:comment "The marker set PVALB, TAC1, MYO5B can identify the Human cell type pvalb GABAergic cortical interneuron in the neocortex with a confidence of 0.691998764 (NS-Forest FBeta value)." ; rdfs:label "pvalb GABAergic cortical interneuron" ; rdfs:subClassOf obo:CL_4023069, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000013502 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000080 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023069 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000013502 ] ) ] . obo:CL_4023019 obo:IAO_0000115 "A VIP GABAergic cortical interneuron that expresses cck. L5/6 cck cells have soma found mainly in L5 and L6 and have large axonal arborization." ; terms:contributor ; oboInOwl:hasExactSynonym "L5/6 CCK Vip (Mus musculus)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "L5/6 cck, VIP GABAergic interneuron (Mmus)" ; rdfs:subClassOf obo:CL_4023016, obo:CL_4023071, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_P32648 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023071 [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_P32648 ] ) ] . obo:CL_4023020 obo:IAO_0000115 "A gamma motor neuron that innervates dynamic nuclear bag fibers (bag1 fibers) and enhances the sensitivities of Ia sensory neurons. They alter muscle spindle sensitivity and increases its discharge in response to velocity of muscle length (rather than just magnitude)." ; terms:contributor ; a owl:Class ; rdfs:label "dynamic gamma motor neuron" ; rdfs:subClassOf obo:CL_0008037, [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_4023005 ] . obo:CL_4023021 obo:IAO_0000115 "A gamma motor neuron that innervates static nuclear bag fibers (bag2 fibers) and increases their firing, in response to an increase in the magnitude of change in length, and controls the static sensitivity of the stretch reflex." ; terms:contributor ; a owl:Class ; rdfs:label "static gamma motor neuron" ; rdfs:subClassOf obo:CL_0008037, [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_4023006 ] . obo:CL_4023022 obo:IAO_0000028 "canopy lamp5 interneuron" ; obo:IAO_0000115 "A Lamp5 GABAergic cortical interneuron that has extended axons in the surface of L1. Canopy Lamp5 cells resemble neurogliaform cells in having elongated horizontal axonal arbors largely confined to L1; but the dendritic arbors are wider and have fewer branches, while the axon is less tortuous and extends further from the soma" ; terms:contributor ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "canopy lamp5 GABAergic cortical interneuron (Mmus)" ; rdfs:subClassOf obo:CL_4023011, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_Q9D387 ] . obo:CL_4023023 obo:IAO_0000028 "L5,6 NGC Lamp5 interneuron (Mus)" ; obo:IAO_0000115 "A lamp 5 GABAergic cortical interneuron with neurogliaform morphology with a soma found in L5,6. L5,6 NGC lamp5 have deep afterhyperpolarization (AHP) but narrow action potentials (APs). Unlike other deep neurogliaform cells (which are caudal ganglionic eminence (CGE) derived), L5,6 NGC lamp5 cells are medial ganglionic eminence (MGE)-derived" ; terms:contributor ; oboInOwl:hasExactSynonym "L5,6 NGC Lamp5 (Mus musculus)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "L5,6 neurogliaform lamp5 GABAergic interneuron (Mmus)" ; rdfs:subClassOf obo:CL_0000693, obo:CL_4023011, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_Q9D387 ] . obo:CL_4023024 obo:IAO_0000028 "NGC Lamp5 interneuron (Mus)" ; obo:IAO_0000115 "A lamp5 GABAergic cortical interneuron with layer-adapting morphology. NGC lamp5 cells have a small round soma, short dendrites, and a wide dense axonal arbor that tends to establish a dense axonal mesh with high connection probability both to themselves and L2 pyramidal cells. NGC lamp5 cells have unique synaptic properties that distinguish them from other GABAergic interneurons, including the release of GABA to the extracellular space via volume transmission, and the ability to produce GABA-B responses in connected postsynaptic targets." ; terms:contributor ; oboInOwl:hasExactSynonym "NGC Lamp5 (Mus musculus)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "neurogliaform lamp5 GABAergic cortical interneuron (Mmus)" ; rdfs:subClassOf obo:CL_0000693, obo:CL_4023011, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_Q9D387 ] . obo:CL_4023025 obo:IAO_0000115 "A sst GABAergic cortical interneuron that is both an interneuron and a projecting neuron. They are found in all layers from upper L2/3 down to the bottom of L6. They have long-range projections, some with axons fading into white matter. These cells have low rebound potential, low hyperpolarization sag, and high variability in membrane time constant." ; terms:contributor ; oboInOwl:hasExactSynonym "LP SST (Mus musculus)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "long-range projecting sst GABAergic cortical interneuron (Mmus)" ; rdfs:subClassOf obo:CL_4023121, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_P60041 ] . obo:CL_4023026 obo:IAO_0000115 "A medium spiny neuron that expresses dopamine type 1 receptors and projects to the globus pallidus internus or the substantia nigra pars reticulata." ; terms:contributor ; oboInOwl:hasExactSynonym "D1-MSN", "dSPN", "dopamine 1 medium spiny neuron" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "direct pathway medium spiny neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_1001474, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001175 ] . obo:CL_4023027 obo:IAO_0000028 "L5 T Martinotti sst interneuron (Mus)" ; obo:IAO_0000115 "A sst GABAergic cortical interneuron with a soma found in L5 and possesses 'T-shaped' Martinotti morphologies with local axonal plexus in L5a and translaminar axons restricted to the uppermost part of L1. They show low-threshold spiking patterns with strong rebound firing, and inhibit the L1 apical tuft of nearby pyramidal cells." ; terms:contributor ; oboInOwl:hasExactSynonym "L5 T Martinotti SST (Mus musculus)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "L5 sst T-Martinotti interneuron (Mmus)" ; rdfs:subClassOf obo:CL_0010011, obo:CL_4023086, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005394 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_P60041 ] . obo:CL_4023028 obo:IAO_0000028 "L5 non-Martinotti sst interneuron (Mus)" ; obo:IAO_0000115 "A sst GABAergic cortical interneuron with a soma found in lower L5 with mostly local axonal arborization but with some sparse ascending axons. L5 non-Martinotti sst cells show somatic localization and local axon plexus in L5b and L5b/6 and substantial innervation of L3 and L4, and receive thalamic input from the ventral posteromedial nucleus and specifically target L4 neurons, avoiding L5 pyramidal cells. L5 non-Martinotti sst cells tend to show a higher input resistance and seem to be less stuttering." ; terms:contributor ; oboInOwl:hasExactSynonym "L5 non-Martinotti SST (Mus musculus)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "L5 non-Martinotti sst GABAergic interneuron (Mmus)" ; rdfs:subClassOf obo:CL_0010011, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005394 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_P60041 ] . obo:CL_4023029 obo:IAO_0000115 "A medium spiny neuron that expresses dopamine type 2 receptors and projects to the external globus pallidus." ; terms:contributor ; oboInOwl:hasExactSynonym "D2-MSN", "dopamine 2 medium spiny neuron", "iSPN" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "indirect pathway medium spiny neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_1001474, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001177 ] . obo:CL_4023030 obo:IAO_0000028 "L2/3/5 fan Martinotti sst interneuron (Mus)" ; obo:IAO_0000115 "A sst GABAergic cortical interneuron that has \"fanning-out' Martinotti morphology that is found in layer 2/3/5 of the cerebral cortex. They have local axon arbor and long ascending axons that spreads horizontally and arborizes significantly in L1." ; terms:contributor ; oboInOwl:hasExactSynonym "L2/3/5 fan Martinotti SST (Mus musculus)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:comment "L2/3/5 fan Martionotti SST cells have an adapting firing pattern and non-zero afterdepolarization (ADP)." ; rdfs:label "L2/3/5 fan Martinotti sst GABAergic interneuron (Mmus)" ; rdfs:subClassOf obo:CL_0010011, obo:CL_4023087, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_P60041 ] . obo:CL_4023031 obo:IAO_0000028 "L4 sst interneuron (Mus)" ; obo:IAO_0000115 "A sst GABAergic cortical interneuron with a soma found in lower L2/3 and upper 5, L4 Sst cells have Martinotti morphology with ascending axons but denser local axons and sparser ‘fanning-out’ projections to L1. L4 sst cells have smaller membrane time constant to calb2 (L2/3/5 fan Martinotti Cell) and non-zero afterdepolarization (ADP)." ; terms:contributor ; oboInOwl:hasExactSynonym "L4 SST (Mus musculus)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "L4 sst Martinotti interneuron (Mmus)" ; rdfs:subClassOf obo:CL_0010011, obo:CL_4023076, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005393 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_P60041 ] . obo:CL_4023032 terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "A retinal ganglion cell that is depolarized by illumination of its receptive field center." ; rdfs:label "ON retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740 . obo:CL_4023033 obo:IAO_0000115 "A retinal ganglion cell that is depolarized by decreased illumination of their receptive field center." ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "OFF retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000740 . obo:CL_4023034 obo:IAO_0000115 "OBSOLETE A sst GABAergic cortical interneuron transcriptomically between the sst and the pvalb families with a soma found in L2/3. Some L2/3 PV-like sst cells have Martinotti morphology while some have basket cell morphology. L2/3 PV-like sst cells have lower AP width and higher firing rate than typical Sst subclass cells. L2/3 PV-like sst cells have high maximum firing rate variability, with many classified as belonging to the pvalb subclass on the basis of electrophysiology." ; obo:IAO_0000233 ; obo:IAO_0100001 obo:PCL_1000002 ; terms:contributor ; oboInOwl:hasExactSynonym "L2/3 PV-like SST Mus)" ; a owl:Class ; rdfs:comment "Moved to PCL. Use PCL:1000002 instead." ; rdfs:label "obsolete L2/3 pvalb-like sst GABAergic cortical interneuron (Mus musculus)" ; owl:deprecated true . obo:CL_4023035 obo:IAO_0000115 "A neuron that is derived from a precursor cell in the lateral ganglion eminence." ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0002-7073-9172" ; oboInOwl:hasExactSynonym "LGE-derived neuron" ; a owl:Class ; rdfs:label "lateral ganglionic eminence derived neuron"@en ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004025 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004025 ] ) ] . obo:CL_4023036 obo:IAO_0000028 "chandelier PV interneuron" ; obo:IAO_0000115 "A transcriptomically distinct pvalb GABAergic cortical interneuron that is recognizable by the straight terminal axonal 'cartridges' of vertically oriented strings of synaptic boutons. Chandelier PV cells' boutons target exclusively the axon initial segment (AIS) of pyramidal cells, with a single cell innervating hundreds of pyramidal cells in a clustered manner. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Chandelier." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasDbXref "ILX:0107356" ; oboInOwl:hasExactSynonym "Chandelier PV" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:comment "In mice, Chandelier PV cells have soma found in in upper L2/3, with some in deep L5 and exhibit fast-spiking but lower firing rate compared to basket cells, and have practically absent hyperpolarization sag.", "The marker set GPR149, CA8 can identify the Human cell type chandelier pvalb GABAergic cortical interneuron in the neocortex with a confidence of 0.799748111 (NS-Forest FBeta value)." ; rdfs:label "chandelier pvalb GABAergic cortical interneuron" ; rdfs:subClassOf obo:CL_4023018, obo:CL_4023083, [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000063 ] . obo:CL_4023038 obo:IAO_0000028 "L6b glut" ; obo:IAO_0000115 "A glutamatergic neuron with a soma found in cortical layer 6b. They are transcriptomically related to corticothalamic-projecting neurons but have differential projections to the thalamus or anterior cingulate. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neuron', Author Categories: 'CrossArea_subclass', cluster L6b." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770163" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "L6b glutamatergic cortical neuron" ; rdfs:subClassOf obo:CL_0000679, obo:CL_0010012, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8440003 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000679 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8440003 ] ) ] . obo:CL_4023039 obo:IAO_0000115 "Any neuron that has its soma located in some amygdala and is capable of some glutamate secretion, neurotransmission." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "An excitatory neuron that is located in the amygdala." ; rdfs:label "amygdala excitatory neuron" ; rdfs:subClassOf obo:CL_0000679, obo:CL_0012001, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001876 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001876 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061535 ] ) ] . obo:CL_4023040 obo:IAO_0000028 "L2/3-6 IT glut" ; obo:IAO_0000115 "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layers L2/3-6." ; terms:contributor ; oboInOwl:hasExactSynonym "L2/3-6 IT projecting neuron" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:label "L2/3-6 intratelencephalic projecting glutamatergic neuron" ; rdfs:subClassOf obo:CL_4023008 . obo:CL_4023041 obo:IAO_0000028 "L5 ET glut" ; obo:IAO_0000115 "A transcriptomically distinct glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons ', Author Categories: 'CrossArea_subclass', clusters L5 ET." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasBroadSynonym "subcerebral projection (SCPN) neuron" ; oboInOwl:hasExactSynonym "Pyramidal tract-like (PT-l)", "burst-firing layer 5 neuron", "thick-tufted layer 5 (TTL5) pyramidal neuron" ; oboInOwl:hasNarrowSynonym "pyramidal tract (PT) neuron" ; oboInOwl:hasRelatedSynonym "L5b neuron" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:comment "The marker set CHST8, POU3F1 can identify the Human cell type L5 extratelencephalic projecting glutamatergic cortical neuron in the neocortex with a confidence of 0.815891473 (NS-Forest FBeta value)." ; rdfs:label "L5 extratelencephalic projecting glutamatergic cortical neuron" ; rdfs:subClassOf obo:CL_4023009, obo:CL_4023111, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005394 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000067 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023009 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005394 ] ) ] . obo:CL_4023042 obo:IAO_0000028 "L6 CT glut" ; obo:IAO_0000115 "A transcriptomically distinct corticothalamic-projecting neuron with a soma found in cortical layer 6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons', Author Categories: 'CrossArea_subclass', clusters L6 CT." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasExactSynonym "L6 CT" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:comment "The marker set SEMA5B, ADAMTSL1, SULF1 can identify the Human cell type L6 corticothalamic-projecting glutamatergic cortical neuron in the neocortex with a confidence of 0.631898455 (NS-Forest FBeta value)." ; rdfs:label "L6 corticothalamic-projecting glutamatergic cortical neuron" ; rdfs:subClassOf obo:CL_4023013, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005395 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0010225 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000070 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023013 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005395 ] ) ] . obo:CL_4023043 obo:IAO_0000028 "L5/6 NP glut MOp" ; obo:IAO_0000115 "A transcriptomically distinct near-projecting glutamatergic neuron with a soma found in layer 5/6 of the primary motor cortex. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons', Author Categories: 'CrossArea_subclass', cluster L5/6 NP." ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770161" ; oboInOwl:hasExactSynonym "L5/6 NP M1", "L5/6 NP MOp" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:label "L5/6 near-projecting glutamatergic neuron of the primary motor cortex" ; rdfs:subClassOf obo:CL_4030067, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001384 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4030067 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001384 ] ) ] . obo:CL_4023044 obo:IAO_0000028 "non-MY ET glut MOp" ; obo:IAO_0000115 "An extratelencephalic-projecting glutamatergic neuron located in layer 5b of the primary motor cortex that does not project to the medulla. Non-MY ET cells are large, big-tufted cells with the apical dendrite often bifurcating close to the soma, suggesting they are corticospinal cells. Non-MY ET cells have bigger hyperpolarization sag, lower input resistance, and smaller AP width, compared to L5 IT neurons." ; terms:contributor ; oboInOwl:hasExactSynonym "non-MY ET M1", "non-MY ET MOp (Mus)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "non-medulla, extratelencephalic-projecting glutamatergic neuron of the primary motor cortex" ; rdfs:subClassOf obo:CL_2000049, obo:CL_4023041 . obo:CL_4023045 obo:IAO_0000028 "MY ET glut MOp" ; obo:IAO_0000115 "An extratelencephalic-projecting glutamatergic neuron located in layer 5b of the primary motor cortex that projects to the medulla. MY ET cells are large, big-tufted cells with the apical dendrite often bifurcating close to the soma, suggesting they are corticospinal cells. MY ET cells have bigger hyperpolarization sag, lower input resistance, and smaller AP width, compared to L5 IT neurons." ; terms:contributor ; oboInOwl:hasExactSynonym "MY ET M1", "MY ET MOp", "medulla-projecting extratelencephalic-projecting glutamatergic neuron of the primary motor cortex" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "medulla-projecting glutamatergic neuron of the primary motor cortex" ; rdfs:subClassOf obo:CL_2000049, obo:CL_4023041, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070031 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0001896 ] . obo:CL_4023046 obo:IAO_0000028 "L6b subplate glut" ; obo:IAO_0000115 "An excitatory glutamatergic neuron transcriptomically related to the CT subclass, with a soma preferentially located in the bottom of L6 of the primary motor cortex." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasExactSynonym "L6b subplate glutamatergic neuron of the primary motor cortex" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:comment "The marker set CCN2, ROS1 can identify the Human cell type L6b glutamatergic neuron of the primary motor cortex in the neocortex with a confidence of 0.819940964 (NS-Forest FBeta value)." ; rdfs:label "L6b glutamatergic neuron of the primary motor cortex" ; rdfs:subClassOf obo:CL_4023038, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001384 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000073 ] . obo:CL_4023047 obo:IAO_0000028 "L2/3 IT glut MOp" ; obo:IAO_0000115 "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2/3 of the primary motor cortex." ; terms:contributor ; oboInOwl:hasExactSynonym "L2/3 IT M1", "L2/3 IT MOp" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:label "L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex" ; rdfs:subClassOf obo:CL_4030059, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001384 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4030059 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001384 ] ) ] . obo:CL_4023048 obo:IAO_0000028 "L4/5 IT glut MOp" ; obo:IAO_0000115 "An intratelencephalic-projecting glutamatergic with a soma located in upper L5 of the primary motor cortex. These cells have thin untufted apical dendrites." ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770174" ; oboInOwl:hasExactSynonym "L4/5 IT M1", "L4/5 IT MOp" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:label "L4/5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex" ; rdfs:subClassOf obo:CL_4030062, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001384 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4030062 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001384 ] ) ] . obo:CL_4023049 obo:IAO_0000028 "L5 IT glut MOp" ; obo:IAO_0000115 "An intratelencephalic-projecting glutamatergic neuron with a soma found in L5 of the primary motor cortex." ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770157" ; oboInOwl:hasExactSynonym "L5 IT M1", "L5 IT MOp" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex" ; rdfs:subClassOf obo:CL_4030064, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001384 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4030064 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001384 ] ) ] . obo:CL_4023050 obo:IAO_0000028 "L6 IT glut MOp" ; obo:IAO_0000115 "An intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted." ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770158" ; oboInOwl:hasExactSynonym "L6 IT M1", "L6 IT MOp" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:label "L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex" ; rdfs:subClassOf obo:CL_2000049, obo:CL_4023095, obo:CL_4030065 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4030065 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001384 ] ) ] . obo:CL_4023051 obo:IAO_0000115 "A transcriptomically distinct type of mesothelial fibroblast that is derived from the neural crest, is localized on blood vessels, and is a key component of the pia and arachnoid membranes surrounding the brain. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Non-neuronal cells', Author Categories: 'CrossArea_subclass', clusters VLMC." ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770143" ; oboInOwl:hasExactSynonym "VLMC" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:label "vascular leptomeningeal cell" ; rdfs:subClassOf obo:CL_4023058, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0011012 ] . obo:CL_4023052 obo:IAO_0000115 "A Betz cell that synapses with lower motor neurons directly." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; a owl:Class ; rdfs:label "Betz upper motor neuron" ; rdfs:subClassOf obo:CL_0008049, [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_0008039 ] . obo:CL_4023053 obo:IAO_0000115 "A Betz cell that syanpses with spinal interneurons." ; obo:RO_0002175 obo:NCBITaxon_9685, obo:NCBITaxon_9989 ; terms:contributor ; a owl:Class ; rdfs:label "spinal interneuron synapsing Betz cell" ; rdfs:subClassOf obo:CL_0008049, [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_0005000 ] . obo:CL_4023054 obo:IAO_0000115 "A mesothelial cell that has undergone mesothelial-to-mesenchymal transition (MMT) to become a fibroblast cell." ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "mesothelial fibroblast" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000077 ] . obo:CL_4023055 obo:IAO_0000028 "CT VAL/VM glut MOp" ; obo:IAO_0000115 "A corticothalamic-projecting glutamatergic neuron that is located in L6 and lower L5 of the primary motor cortex, with a pyramidal morphology and mostly untufted apical dendrites terminating in midcortical layers. CT VAL/VM (ventroanterior-ventrolateral complex/ventromedial nucleus) cells have a near tonic firing pattern and are distinguished from L6 IT neurons by a lower inter-spike interval adaptation index." ; terms:contributor ; oboInOwl:hasExactSynonym "CT VAL/VM M1", "CT VAL/VM MOp" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:comment "The assertion of this cell type under L6 CT is due to the ambiguity of lower L5 and L6." ; rdfs:label "corticothalamic VAL/VM projecting glutamatergic neuron of the primary motor cortex" ; rdfs:subClassOf obo:CL_2000049, obo:CL_4023042, obo:CL_4023095 . obo:CL_4023056 obo:IAO_0000115 "A type of mouse mesothelial fibroblast that is derived from the neural crest, is localized on blood vessels, and is a key component of the pia and arachnoid membranes surrounding the brain." ; terms:contributor ; oboInOwl:hasExactSynonym "VLMC (Mus musculus)" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:label "vascular leptomeningeal cell (Mmus)" ; rdfs:subClassOf obo:CL_4023051, _:genid14930, _:genid14932, _:genid14934, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] . obo:CL_4023057 obo:IAO_0000115 "Any GABAergic interneuron that has its soma located in some cerebellar cortex." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "A GABAergic interneuron whose soma is located in the cerebellar cortex." ; rdfs:label "cerebellar inhibitory GABAergic interneuron" ; rdfs:subClassOf obo:CL_0011005, obo:CL_1001611, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002129 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011005 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002129 ] ) ] ; skos:prefLabel "cerebellar inhibitory GABAergic interneuron" . obo:CL_4023058 obo:IAO_0000115 "A mesothelial fibroblast found in the leptomeninx." ; terms:contributor ; a owl:Class ; rdfs:label "mesothelial fibroblast of the leptomeninx" ; rdfs:subClassOf obo:CL_0002319, obo:CL_4023054, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000391 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023054 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000391 ] ) ] . obo:CL_4023059 obo:IAO_0000115 "An oligodendrocyte precursor cell that is committed to differentiate." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasExactSynonym "COP", "differentiation-committed oligodendrocyte precursor" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "COPs are distinct from OPCs in that the lack expression of Pdgfra and Cspg4 and come out as distinct clusters in transcriptomic profiling. This is the reason that this term is not modelled as a subclassOf OPC but instead linked using develops_from." ; rdfs:label "committed oligodendrocyte precursor" ; rdfs:subClassOf obo:CL_0000123, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002453 ] . obo:CL_4023060 obo:IAO_0000115 "A neuron that has its soma located in CA1-3 of the hippocampus." ; obo:IAO_0000116 "It is unclear as to if the modelling of Ammon's horn includes CA4 (which could be considered part of the dentate gyrus) in Uberon, hence no equivalent class axiom was made." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "hippocampal CA1-3 neuron" ; rdfs:subClassOf obo:CL_0002608, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001954 ] . obo:CL_4023061 obo:IAO_0000115 "A neuron that has its soma located in CA4 of the hippocampus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "hippocampal CA4 neuron" ; rdfs:subClassOf obo:CL_2000029 . obo:CL_4023062 obo:IAO_0000115 "A neuron with its soma located in the dentate gyrus of the hippocampus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "dentate gyrus neuron" ; rdfs:subClassOf obo:CL_0002608, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001885 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001885 ] ) ] ; skos:prefLabel "dentate gyrus neuron" . obo:CL_4023063 obo:IAO_0000028 "MGE interneuron" ; obo:IAO_0000115 "An interneuron that is derived from the medial ganglionic eminence." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasExactSynonym "MGE interneuron" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "medial ganglionic eminence derived interneuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000099, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004024 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004024 ] ) ] . obo:CL_4023064 obo:IAO_0000028 "CGE interneuron" ; obo:IAO_0000115 "An interneuron that is derived from the caudal ganglionic eminence." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasExactSynonym "caudal ganglionic eminence derived GABAergic cortical interneuron" ; oboInOwl:hasRelatedSynonym "CGE cortical interneuron", "CGE interneuron", "CGE-derived GABAergic IN", "CGE-derived cell", "CGE-derived interneuron" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "caudal ganglionic eminence derived cortical interneuron" ; rdfs:subClassOf obo:CL_0010011, obo:CL_4042039 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004026 ] ) ] . obo:CL_4023065 obo:IAO_0000028 "meis2 GABA" ; obo:IAO_0000115 "A GABAergic cell located in the cerebral cortex that expresses meis2." ; terms:contributor ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:label "meis2 expressing cortical GABAergic cell" ; rdfs:subClassOf obo:CL_0000617, obo:CL_0010012, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000010317 ] . obo:CL_4023066 obo:IAO_0000115 "A pyramidal neuron which has an apical tree which is oriented parallel to the pia. This is unlike typical pyramidal neurons which have its apical dendrite aligned vertically." ; terms:contributor ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "horizontal pyramidal neuron" ; rdfs:subClassOf obo:CL_0000598, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070016 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070016 ] ) ] . obo:CL_4023067 obo:IAO_0000115 "OBSOLETE A L2/3 pvalb-like sst GABAergic cortical interneuron (Mus musculus) that has Martinotti morphology." ; obo:IAO_0000233 ; obo:IAO_0100001 obo:PCL_1000004 ; terms:contributor ; oboInOwl:hasExactSynonym "Martinotti L2/3 PV-like SST (Mus)" ; a owl:Class ; rdfs:comment "Moved to PCL. Use PCL:1000004 instead." ; rdfs:label "obsolete Martinotti morphology L2/3 pvalb-like sst GABAergic cortical interneuron (Mus musculus)" ; owl:deprecated true . obo:CL_4023068 obo:IAO_0000115 "An excitatory neuron that has its soma located in the thalamic complex. This neuron type can be involved in a series of circuits related to sensory integration, motor integration, pain processing, social behaviour and reward response." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Abnormalities in glutametergic neurons of the thalamic complex are associated with pathologies such as schizophrenia, colorectal visceral pain and Parkinson's disease." ; rdfs:label "thalamic excitatory neuron" ; rdfs:subClassOf obo:CL_0000679, obo:CL_0012001, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0010225 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0010225 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061535 ] ) ] . obo:CL_4023069 obo:IAO_0000028 "MGE cortical gaba interneuron" ; obo:IAO_0000115 "A GABAergic cortical interneuron that develops from the medial ganglionic eminence and has migrated to the cerebral cortex." ; terms:contributor ; oboInOwl:hasExactSynonym "MGE cortical interneuron" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "medial ganglionic eminence derived GABAergic cortical interneuron" ; rdfs:subClassOf obo:CL_0010011, obo:CL_4023063 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004024 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ) ] . obo:CL_4023070 obo:IAO_0000028 "CGE gaba cortical interneuron" ; obo:IAO_0000115 "OBSOLETE. A GABAergic cortical interneuron that develops from the caudal ganglionic eminence and has migrated to the cerebral cortex." ; obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_4023064 ; terms:contributor ; oboInOwl:hasExactSynonym "CGE cortical interneuron" ; a owl:Class ; rdfs:comment """caudal ganglionic eminence derived GABAergic interneuron and caudal ganglionic eminence derived interneuron are the same cell type. The two must be merged and one needs to be defined as obsolete. We decided to deprecate the entity with the more specific term and redundant qualities in the label. See comments in issue 2357.""" ; rdfs:label "obsolete caudal ganglionic eminence derived GABAergic cortical interneuron" ; owl:deprecated true . obo:CL_4023071 obo:IAO_0000028 "L5/6 cck interneuron (Mus)" ; obo:IAO_0000115 "A GABAergic cortical interneuron that expresses cck. L5/6 cck cells have soma found mainly in L5 and L6 and have large axonal arborization." ; terms:contributor ; oboInOwl:hasExactSynonym "L5/6 CCK (Mus musculus)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "L5/6 cck GABAergic interneuron (Mmus)" ; rdfs:subClassOf obo:CL_0010011, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8440002 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_P09240 ] . obo:CL_4023072 obo:IAO_0000115 "A cell that is part of the brain vasculature." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "brain vascular cell" ; rdfs:subClassOf obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008998 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008998 ] ) ] . obo:CL_4023073 obo:IAO_0000115 "OBSOLETE. A cell that is part of the choroid plexus." ; obo:IAO_0000233 ; obo:IAO_0100001 obo:CL_0000706 ; terms:contributor ; a owl:Class ; rdfs:label "obsolete choroid plexus cell" ; owl:deprecated true . obo:CL_4023074 obo:IAO_0000115 "A neuron that has its soma located in the mammillary body." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mammillary body neuron" ; rdfs:subClassOf obo:CL_0012001, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002206 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002206 ] ) ] . obo:CL_4023075 obo:IAO_0000028 "L6 th sst interneuron (Mus)" ; obo:IAO_0000115 "A sst GABAergic cortical interneuron found in L6 that expresses tyrosine hydroxylase. L6 Th+ SST cells have mostly local axonal arborization within L6." ; terms:contributor ; oboInOwl:hasExactSynonym "L6 Th+ SST (Mus musculus)", "L6 tyrosine hydroxylase positive sst expressing GABAergic cortical interneuron (Mus musculus)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "L6 th sst GABAergic interneuron (Mmus)" ; rdfs:subClassOf obo:CL_0010011, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005395 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_P24529 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_P60041 ] . obo:CL_4023076 obo:IAO_0000115 "An interneuron that has Martinotti morphology. These interneurons are scattered throughout various layers of the cerebral cortex, sending their axons up to the cortical layer I where they form axonal arborization." ; terms:contributor ; oboInOwl:hasDbXref "ILX:0107375", "NIFEXT:55" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "Martinotti neuron" ; rdfs:subClassOf obo:CL_0011005, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070007 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070007 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ) ] . obo:CL_4023077 obo:IAO_0000115 "A type of interneuron that has two clusters of dendritic branches that originate directly from the soma and extend in opposite directions and axons that form a plexus which spreads widely. Compared to bipolar neurons, bitufted neurons have branching that occur close to the soma." ; terms:contributor ; oboInOwl:hasDbXref "ILX:0777212" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "bitufted neuron" ; rdfs:subClassOf obo:CL_0000099, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070012 ] ) ] . obo:CL_4023078 obo:IAO_0000115 "OBSOLETE A L2/3 pvalb-like sst GABAergic cortical interneuron (Mus musculus) that has basket morphology." ; obo:IAO_0000233 ; obo:IAO_0100001 obo:PCL_1000003 ; terms:contributor ; oboInOwl:hasExactSynonym "basket L2/3 PV-like SST (Mus)" ; a owl:Class ; rdfs:comment "Moved to PCL. Use PCL:1000003 instead." ; rdfs:label "obsolete basket morphology L2/3 pvalb-like sst GABAergic cortical interneuron (Mus musculus)" ; owl:deprecated true . obo:CL_4023079 obo:IAO_0000115 "A GABAergic inhibitory neuron that is derived from the midbrain." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "midbrain-derived inhibitory neuron" ; rdfs:subClassOf obo:CL_2000029, obo:UBERON_0004121, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001891 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001891 ] ) ] . obo:CL_4023080 obo:IAO_0000028 "stellate L6 IT glut MOp" ; obo:IAO_0000115 "a L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex that has stellate pyramidal morphology." ; terms:contributor ; oboInOwl:hasExactSynonym "stellate L6 IT MOp (Mus musculus)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "stellate L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus)" ; rdfs:subClassOf obo:CL_4023050, obo:CL_4023093 . obo:CL_4023081 obo:IAO_0000028 "inverted L6 IT glut MOp" ; obo:IAO_0000115 "a L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex that has inverted pyramidal morphology." ; terms:contributor ; oboInOwl:hasExactSynonym "inverted L6 IT MOp (Mus musculus)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "inverted L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus)" ; rdfs:subClassOf obo:CL_4023050, obo:CL_4023092 . obo:CL_4023083 obo:IAO_0000115 "A GABAergic interneuron that selectively innervates the axon initial segment of pyramidal cells. Their local axonal clusters are formed by high-frequency branching at shallow angles, often ramifying around, above or below their somata with a high bouton density. The characteristic terminal portions of the axon form short vertical rows of boutons, resembling the candlesticks and candles of a chandelier. Chandelier cells can be multipolar or bitufted." ; terms:contributor ; oboInOwl:hasBroadSynonym "axo-axonic cell" ; oboInOwl:hasDbXref "ILX:0777213" ; oboInOwl:hasRelatedSynonym "ChC" ; oboInOwl:inSubset cl:BDS_subset, cl:cellxgene_subset ; a owl:Class ; rdfs:label "chandelier cell" ; rdfs:subClassOf obo:CL_0011005, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070011 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011005 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070011 ] ) ] . obo:CL_4023086 obo:IAO_0000115 "A Martinotti neuron that has axons that form a horizontal ramification, making it T-shaped." ; terms:contributor ; oboInOwl:hasExactSynonym "T-shaped Martinotti neuron" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "T Martinotti neuron" ; rdfs:subClassOf obo:CL_4023076, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070008 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070008 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ) ] . obo:CL_4023087 obo:IAO_0000115 "A Martinotti neuron that has axons that form a fan-like plexus." ; terms:contributor ; oboInOwl:hasExactSynonym "fanning-out Martinotti neuron" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "fan Martinotti neuron" ; rdfs:subClassOf obo:CL_4023076, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070009 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070009 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ) ] . obo:CL_4023088 obo:IAO_0000115 "A basket cell that is large, and typically ascends to give rise to many long horizontally and vertically projecting axon collaterals that traverse neighboring columns and can extend through all cortical layers." ; terms:contributor ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "large basket cell" ; rdfs:subClassOf obo:CL_2000086, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070004 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001950 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ) ] . obo:CL_4023089 obo:IAO_0000115 "A basket cell which has simpler dendritic arbors (compared to small or large basket cells), and an axonal plexus of intermediate density, composed of a few long, smooth axonal branches." ; terms:contributor ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "nest basket cell" ; rdfs:subClassOf obo:CL_2000086, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070005 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070005 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001950 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ) ] . obo:CL_4023090 obo:IAO_0000115 "A basket cell with axonal arbors composed of frequent, short, curvy axonal branches that tend to be near their somata and within the same layer." ; terms:contributor ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "small basket cell" ; rdfs:subClassOf obo:CL_2000086, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070003 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001950 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ) ] . obo:CL_4023092 obo:IAO_0000115 "A pyramidal neuron which has an apical tree which is oriented towards the white matter." ; terms:contributor ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "inverted pyramidal neuron" ; rdfs:subClassOf obo:CL_0000598, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070021 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070021 ] ) ] . obo:CL_4023093 obo:IAO_0000115 "A pyramidal neuron which lacks a tuft formation but extends small radial distances forming a star-like shape." ; terms:contributor ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "stellate pyramidal neuron" ; rdfs:subClassOf obo:CL_0000598, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070020 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070020 ] ) ] . obo:CL_4023094 obo:IAO_0000115 "A pyramidal neuron which has a distinctive tuft formation, distal from the soma." ; terms:contributor ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "tufted pyramidal neuron" ; rdfs:subClassOf obo:CL_0000598, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070018 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070018 ] ) ] . obo:CL_4023095 obo:IAO_0000115 "A pyramidal neuron which lacks a clear tuft formation but extends to large radial distances." ; terms:contributor ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "untufted pyramidal neuron" ; rdfs:subClassOf obo:CL_0000598, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070019 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070019 ] ) ] . obo:CL_4023097 obo:IAO_0000115 "A mesothelial fibroblast of the arachnoid barrier layer. Arachnoid barrier cells make up the tight-junctioned layer in the leptomeninx that functions as the physiologic barrier between the cerebrospinal fluid in the subarachnoid space and the fenestrated capillaries in the dura." ; terms:contributor ; oboInOwl:hasRelatedSynonym "AB cell", "ABC" ; a owl:Class ; rdfs:label "arachnoid barrier cell" ; rdfs:subClassOf obo:CL_4023058, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000437 ] . obo:CL_4023098 obo:IAO_0000115 "OBSOLETE An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 2/3 of the human primary motor cortex." ; obo:IAO_0100001 obo:CL_4023047 ; terms:contributor ; oboInOwl:hasExactSynonym "L2/3 IT MOp (human)" ; a owl:Class ; rdfs:comment "Made terms species agnostic, use CL:4023047 instead." ; rdfs:label "obsolete L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Homo sapiens)" ; owl:deprecated true . obo:CL_4023099 obo:IAO_0000115 "OBSOLETE. An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 5 of the human primary motor cortex." ; obo:IAO_0100001 obo:CL_4023049 ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770157" ; oboInOwl:hasExactSynonym "L5 IT MOp (human)" ; a owl:Class ; rdfs:comment "Made terms species agnostic, use CL:4023049 instead." ; rdfs:label "obsolete L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Homo sapiens)" ; owl:deprecated true . obo:CL_4023100 obo:IAO_0000115 "OBSOLETE. An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 6 of the human primary motor cortex." ; obo:IAO_0100001 obo:CL_4023050 ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770158" ; oboInOwl:hasExactSynonym "L6 IT MOp (human)" ; a owl:Class ; rdfs:comment "Made terms species agnostic, use CL:4023050 instead." ; rdfs:label "obsolete L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Homo sapiens)" ; owl:deprecated true . obo:CL_4023101 obo:IAO_0000115 "OBSOLETE. A near-projecting glutamatergic neuron with a soma found in layer 5/6 of the human primary motor cortex." ; obo:IAO_0100001 obo:CL_4023043 ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770161" ; oboInOwl:hasExactSynonym "L5/6 NP MOp (human)" ; a owl:Class ; rdfs:comment "Made terms species agnostic, use CL:4023043 instead." ; rdfs:label "obsolete L5/6 near-projecting glutamatergic neuron of the primary motor cortex (Homo sapiens)" ; owl:deprecated true . obo:CL_4023102 obo:IAO_0000115 "OBSOLETE. A near-projecting glutamatergic neuron with a soma found in layer 5/6 of the marmoset primary motor cortex." ; obo:IAO_0100001 obo:CL_4023043 ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770161" ; oboInOwl:hasExactSynonym "L5/6 NP MOp (marmoset)" ; a owl:Class ; rdfs:comment "Made terms species agnostic, use CL:4023043 instead." ; rdfs:label "obsolete L5/6 near-projecting glutamatergic neuron of the primary motor cortex (Callithrix jacchus)" ; owl:deprecated true . obo:CL_4023103 obo:IAO_0000115 "OBSOLETE. An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 2/3 of the marmoset primary motor cortex." ; obo:IAO_0100001 obo:CL_4023047 ; terms:contributor ; oboInOwl:hasExactSynonym "L2/3 IT MOp (marmoset)" ; a owl:Class ; rdfs:comment "Made terms species agnostic, use CL:4023047 instead." ; rdfs:label "obsolete L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Callithrix jacchus)" ; owl:deprecated true . obo:CL_4023104 obo:IAO_0000115 "OBSOLETE An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 5 of the marmoset primary motor cortex." ; obo:IAO_0100001 obo:CL_4023049 ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770157" ; oboInOwl:hasExactSynonym "L5 IT MOp (marmoset)" ; a owl:Class ; rdfs:comment "Made terms species agnostic, use CL:4023049 instead." ; rdfs:label "obsolete L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Callithrix jacchus)" ; owl:deprecated true . obo:CL_4023105 obo:IAO_0000115 "OBSOLETE. An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 6 of the marmoset primary motor cortex." ; obo:IAO_0100001 obo:CL_4023050 ; terms:contributor ; oboInOwl:hasDbXref "ILX:0770158" ; oboInOwl:hasExactSynonym "L6 IT MOp (marmoset)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:comment "Made terms species agnostic, use CL:4023050 instead." ; rdfs:label "obsolete L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Callithrix jacchus)" ; owl:deprecated true . obo:CL_4023106 obo:IAO_0000115 "OBSOLETE. A mouse GABAergic cell located in the marmoset cerebral cortex that expresses meis2." ; obo:IAO_0100001 obo:CL_4023065 ; terms:contributor ; oboInOwl:hasExactSynonym "Meis2 (Marmoset)" ; a owl:Class ; rdfs:comment false ; rdfs:label "obsolete meis2 expressing cortical GABAergic cell (Callithrix jacchus)" ; owl:deprecated true . obo:CL_4023107 obo:IAO_0000115 "A neuron with soma location in the reticular formation with axons that extend into the spinal cord such. Reticulospinal neuron activity can lead to a variety of motor behaviors." ; terms:contributor ; oboInOwl:hasExactSynonym "RSN" ; a owl:Class ; rdfs:label "reticulospinal neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002275 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0002240 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002275 ] [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:CL_4023108 obo:IAO_0000115 "A magnocellular neurosecretory cell that is capable of producing and secreting oxytocin." ; terms:contributor ; a owl:Class ; rdfs:label "oxytocin-secreting magnocellular cell" ; rdfs:subClassOf obo:CL_0011003, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0036162 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011003 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0036162 ] ) ] . obo:CL_4023109 obo:IAO_0000115 "A magnocellular neurosecretory cell that is capable of producing and secreting vasopressin." ; terms:contributor ; a owl:Class ; rdfs:label "vasopressin-secreting magnocellular cell" ; rdfs:subClassOf obo:CL_0000167, obo:CL_0011003, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030103 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011003 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030103 ] ) ] . obo:CL_4023110 obo:IAO_0000115 "A pyramidal neuron with soma located in the amygdala." ; terms:contributor ; a owl:Class ; rdfs:label "amygdala pyramidal neuron" ; rdfs:subClassOf obo:CL_0000598, obo:CL_0012001, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001876 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000598 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001876 ] ) ] . obo:CL_4023111 obo:IAO_0000115 "A pyramidal neuron with soma located in the cerebral cortex." ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cerebral cortex pyramidal neuron" ; rdfs:subClassOf obo:CL_0000598, obo:CL_0010012 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000598 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] . obo:CL_4023112 obo:IAO_0000115 "An afferent neuron of the vestibular system that innervate the base of the hair cell and increase or decrease their neural firing rate as the receptor cell is excited or inhibited." ; terms:contributor ; a owl:Class ; rdfs:label "vestibular afferent neuron" ; rdfs:subClassOf obo:CL_0000101, [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_0000609 ] . obo:CL_4023113 obo:IAO_0000115 "A vestibular afferent neuron that makes bouton synapses to type II hair cells." ; terms:contributor ; a owl:Class ; rdfs:label "bouton vestibular afferent neuron" ; rdfs:subClassOf obo:CL_4023112, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0043195 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002130 ; owl:someValuesFrom obo:CL_0002069 ] . obo:CL_4023114 obo:IAO_0000115 "A vestibular afferent neuron which posseses a unique postsynaptic terminal, the calyx, which completely covers the basolateral walls of type I hair cells and receives input from multiple ribbon synapses." ; terms:contributor ; a owl:Class ; rdfs:label "calyx vestibular afferent neuron" ; rdfs:subClassOf obo:CL_4023112, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0099096 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002130 ; owl:someValuesFrom obo:CL_0002070 ] . obo:CL_4023115 obo:IAO_0000115 "A spiral ganglion neuron that innervates inner hair cells. Type 1 spiral ganglion neurons are myelinated and bipolar." ; terms:contributor ; oboInOwl:hasExactSynonym "type I spiral ganglion cell" ; a owl:Class ; rdfs:comment "Type 1 spiral ganglion neurons comprise the vast majority of spiral ganglion cells." ; rdfs:label "type 1 spiral ganglion neuron" ; rdfs:subClassOf obo:CL_0011113, obo:UBERON_0000122, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070006 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:CL_0000589 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011113 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:CL_0000589 ] ) ] . obo:CL_4023116 obo:IAO_0000115 "A spiral ganglion neuron that innervates outer hair cells. Type 1 spiral ganglion neurons are unmyelinated and unipolar." ; terms:contributor ; oboInOwl:hasExactSynonym "type II spiral ganglion cell" ; a owl:Class ; rdfs:comment "Outer hair cells form reciprocal synapses onto type 2 spiral ganglion cells, suggesting that the type 2 cells have both afferent and efferent roles." ; rdfs:label "type 2 spiral ganglion neuron" ; rdfs:subClassOf obo:CL_0011113, obo:UBERON_0000122, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070025 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:CL_0000601 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011113 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:CL_0000601 ] ) ] . obo:CL_4023118 obo:IAO_0000028 "L5/6 non-Martinotti sst interneuron (Mus)" ; obo:IAO_0000115 "A sst GABAergic interneuron does not have Martinotti morphology with a soma found in L5/6 of the cerebral cortex." ; terms:contributor ; oboInOwl:hasExactSynonym "L5/6 non-Martinotti SST (Mus musculus)", "L5/6 non-Martinotti morphology sst expressing GABAergic cortical interneuron (Mus musculus)" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:comment "L5/6 non-Martinotti SST cells have strongly facilitating excitatory inputs and moderately depressing outputs. They have faster action potential than Martinotti morphology SST cells and slightly slower than PV basket cells." ; rdfs:label "L5/6 non-Martinotti sst GABAergic interneuron (Mmus)" ; rdfs:subClassOf obo:CL_0010011, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8440002 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_P60041 ] . obo:CL_4023119 obo:IAO_0000115 "A subpopulation of amacrine cell that migrate further than other amacrine cells, and come to lie basal to the inner plexiform layer (IPL) in the ganglion cell layer. Displaced amacrine cells still have their neurites extending apically into the IPL, and therefore exhibit an inverted polarity with respect to the other amacrine cells." ; terms:contributor ; oboInOwl:hasExactSynonym "dACs", "inverted amacrine cell" ; a owl:Class ; rdfs:comment "Displaced amacrine cells are a subset of Sox2 expressing amacrine cells." ; rdfs:label "displaced amacrine cell" ; rdfs:subClassOf obo:CL_0000561, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000015426 ] . obo:CL_4023120 obo:IAO_0000115 "An auditory hair cell found in the cochlea." ; terms:contributor ; oboInOwl:hasDbXref "FMA:62364" ; oboInOwl:hasExactSynonym "cochlear hair cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "cochlea auditory hair cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000202, obo:CL_0002374, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002227 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000202 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002227 ] ) ] . obo:CL_4023121 obo:IAO_0000028 "sst chodl cortical interneuron" ; obo:IAO_0000115 "A transcriptomically distinct sst GABAergic cortical interneuron that also expresses Chodl. These neurons are rare and correspond to the only known cortical interneurons with long-range projection. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Sst Chodl." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:hasBroadSynonym "long-range GABAergic interneuron" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "The marker set NPY can identify the Human cell type sst chodl GABAergic cortical interneuron in the neocortex with a confidence of 0.894026187 (NS-Forest FBeta value)." ; rdfs:label "sst chodl GABAergic cortical interneuron" ; rdfs:subClassOf obo:CL_4023017, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000005444 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000083 ] . obo:CL_4023122 obo:IAO_0000115 "An interneuron located in the cerebral cortex that expresses the oxytocin receptor. These interneurons also express somatostatin." ; obo:RO_0002175 obo:NCBITaxon_10090 ; terms:contributor ; oboInOwl:hasRelatedSynonym "OxtrINs" ; a owl:Class ; rdfs:comment "These cells were first identified in mouse." ; rdfs:label "oxytocin receptor sst GABAergic cortical interneuron" ; rdfs:subClassOf obo:CL_0010011, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001635 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000015665 ] . obo:CL_4023123 obo:IAO_0000115 "A kisspeptin neuron that is located in the hypothalamus. These neurons project to and activate gonadotrophin-releasing hormone neurons (acting via the kisspeptin receptor) in the hypothalamus and stimulate the secretion of gonadotrophin-releasing hormone." ; terms:contributor , ; a owl:Class ; rdfs:label "hypothalamus kisspeptin neuron" ; rdfs:subClassOf obo:CL_0012001, obo:CL_4023130, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001898 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023130 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001898 ] ) ] . obo:CL_4023124 obo:IAO_0000115 "A kisspeptin neuron that is located in the dentate gyrus of the hippocampus." ; terms:contributor , ; a owl:Class ; rdfs:label "dentate gyrus kisspeptin neuron" ; rdfs:subClassOf obo:CL_4023062, obo:CL_4023130 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023130 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001885 ] ) ] . obo:CL_4023125 obo:IAO_0000115 "A hypothalamus kisspeptin neuron that coexpresses kisspeptin, neurokinin B and dynorphin." ; terms:contributor , ; oboInOwl:hasExactSynonym "kisspeptin, neurokinin B and dynorphin expressing neuron" ; a owl:Class ; rdfs:comment "KNDy neurons are involved in the negative feedback of gonadotropin-releasing hormone release in the hypothalamic–pituitary–gonadal axis. Sex steroids released from the gonads act on KNDy neurons as inhibitors of kisspeptin release. This inhibition provides negative feedback control on the hypothalamic–pituitary–gonadal axis. Other roles of KNDy neurons include influences on prolactin production; puberty; stress' effects on reproduction; and the control of thermoregulation." ; rdfs:label "KNDy neuron" ; rdfs:subClassOf obo:CL_4023123, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000012526 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016004 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023123 [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000012526 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016004 ] ) ] . obo:CL_4023127 obo:IAO_0000115 "a KNDy neuron that is located in the arcuate nucleus of the hypothalamus." ; terms:contributor , ; a owl:Class ; rdfs:label "arcuate nucleus of hypothalamus KNDy neuron" ; rdfs:subClassOf obo:CL_4023125, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023125 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001932 ] ) ] . obo:CL_4023128 obo:IAO_0000115 "a KNDy neuron that is located in the rostral periventricular region of the third ventricle." ; obo:IAO_0000116 "In rats and mice, the anteroventral periventricular nucleus plus the periventricular nucleus make up the rostral periventricular region of the third ventricle (RP3V)." ; terms:contributor , ; oboInOwl:hasExactSynonym "RP3V KNDy neuron" ; a owl:Class ; rdfs:label "rostral periventricular region of the third ventricle KNDy neuron" ; rdfs:subClassOf obo:CL_4023125, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8440005 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023125 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8440005 ] ) ] . obo:CL_4023129 obo:IAO_0000115 "A retinal cell that is immature or undifferentiated." ; terms:contributor , ; oboInOwl:hasExactSynonym "retinal stem cell" ; oboInOwl:inSubset cl:eye_upper_slim ; a owl:Class ; rdfs:label "retinoblast" ; rdfs:subClassOf obo:CL_0009004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] . obo:CL_4023130 obo:IAO_0000115 "A neuron that expresses kisspeptin. These neurons are predominantly located in the hypothalamus, but also found in other parts of the brain including the hippocampal dentate gyrus." ; terms:contributor , ; a owl:Class ; rdfs:comment "Gonadal sex steroids stimulate kisspeptin neurons in the RP3V, but inhibit kisspeptin neurons in the ARC." ; rdfs:label "kisspeptin neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000009344 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000009344 ] ) ] . obo:CL_4023154 obo:IAO_0000115 "A glial cell that myelinates axonal processes." ; terms:contributor ; a owl:Class ; rdfs:label "myelinating glial cell" ; rdfs:subClassOf obo:CL_0000125, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0043209 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0043209 ] ) ] . obo:CL_4023158 obo:IAO_0000115 "A neuron in the posterior ventral cochlear nucleus that is distinguished by their long, thick and tentacle-shaped dendrites that typically emanate from one side of the cell body." ; obo:IAO_0000116 "This term is restricted to the mammalian cochlear nucleus to disambiguate for cells of octopus." ; terms:contributor ; a owl:Class ; rdfs:comment "Octopus cells respond only at the onset of a broad-band simple tonal stimulus and form a pathway to the superior paraolivary nucleus and to the ventral nucleus of the lateral lemniscus." ; rdfs:label "octopus cell of the mammalian cochlear nucleus" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002831 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_8440043 ] . obo:CL_4023159 obo:IAO_0000115 "An interneuron that has double bouquet morphology." ; terms:contributor ; a owl:Class ; rdfs:label "double bouquet cell" ; rdfs:subClassOf obo:CL_0000099, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070061 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070061 ] ) ] . obo:CL_4023160 obo:IAO_0000115 "A neuron of the dorsal cochlear nucleus with spiny dendrites that receive input from the axons of granule cells and with axons that release GABA and glycine onto cartwheel, pyramidal and giant cell targets." ; terms:contributor ; oboInOwl:hasDbXref "ILX:0102311" ; a owl:Class ; rdfs:comment "Cartwheel cells share many of the features, molecular and electrophysiological, of cerebellar Purkinje neurons." ; rdfs:label "cartwheel cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0008059, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002829 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002103 ; owl:someValuesFrom obo:CL_0000120 ] . obo:CL_4023161 obo:IAO_0000115 "An excitatory glutamatergic interneuron found in the granular layer of the cerebellar cortex and also in the granule cell domain of the cochlear nucleus. Unipolar brush cells have a round or oval cell body with usually a single short dendrite that ends in a brush-like tuft of short dendrites unique to them known as dendrioles." ; terms:contributor ; oboInOwl:hasExactSynonym "neuronal brush cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "unipolar brush cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000099, obo:CL_0000679, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0044293 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070025 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002028 ] ; skos:prefLabel "unipolar brush cell" ; foaf:depiction , . obo:CL_4023162 obo:IAO_0000115 "A neuron found in the anterior part of the ventral cochlear nucleus that has the appearance of bushes, having short dendrites. Bushy cells give outputs to different parts of the superior olivary complex." ; terms:contributor ; a owl:Class ; rdfs:label "bushy cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002830 ], [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0002128 ] . obo:CL_4023163 obo:IAO_0000115 "A bushy cell that receives only few large excitatory endbulb synapses from auditory nerves. Spherical bush cells give excitatory input to the lateral and medial parts of the superior olive." ; terms:contributor ; oboInOwl:hasRelatedSynonym "SBC" ; a owl:Class ; rdfs:label "spherical bushy cell" ; rdfs:subClassOf obo:CL_4023162 . obo:CL_4023164 obo:IAO_0000115 "A bushy cell that receives a large number of medium-sized synapses, called modified endbulbs. Globular bushy cells extend to the superior olive on both sides of the brainstem where they give input to the bipolar neurons." ; terms:contributor ; oboInOwl:hasExactSynonym "GBC" ; a owl:Class ; rdfs:label "globular bushy cell" ; rdfs:subClassOf obo:CL_4023162 . obo:CL_4023168 obo:IAO_0000115 "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli." ; terms:contributor ; a owl:Class ; rdfs:label "somatosensory neuron" ; rdfs:subClassOf obo:CL_2000032, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003942 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003942 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000010 ] ) ] . obo:CL_4023169 obo:IAO_0000115 "A neuron that is responsible for sensation in the face or motor functions such as biting and chewing. Trigeminal neurons extend a single axon shaft along the lateral white matter of the hindbrain and spinal cord. The highly branched axons innervate the integument of the head." ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "trigeminal neuron" ; rdfs:subClassOf obo:CL_2000029 . obo:CL_4023170 obo:IAO_0000115 "A trigeminal neuron that is responsible for sensation in the face." ; terms:contributor ; a owl:Class ; rdfs:label "trigeminal sensory neuron" ; rdfs:subClassOf obo:CL_0000006, obo:CL_4023169, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003942 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023169 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050906 ] ) ] . obo:CL_4023171 obo:IAO_0000115 "A trigeminal neuron that is responsible for motor functions such as biting and chewing." ; terms:contributor ; a owl:Class ; rdfs:label "trigeminal motor neuron" ; rdfs:subClassOf obo:CL_0000100, obo:CL_4023169 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000100 obo:CL_4023169 ) ] . obo:CL_4023181 obo:IAO_0000115 "A neurecto-epithelial cell that is part of the basal layer of the subcommissural organ and specializes in the secretion of proteins into the subarachnoid space. Hypendymal cells have similar characteristics to ependymal cells and express SCO-spondin." ; terms:contributor ; terms:description """Hypendymal cells are secretory cells located between the ependymal layer and the posterior commissure, forming the hypendmal layer of the subcommissural organ (SCO), a highly conserved gland that is part of the circumventricular system within the brain. Hypendymal cells are bipolar cells with a thin apical pole and basal process. Most of the ultrastructural characteristics of these cells are similar to those described for the ependymal cells (which are arranged into another layer – the ependyma). However, ependymal cells release their secretion into the ventricular cerebrospinal fluid whereas hypendymal cells project processes to the local blood vessels and to the subarachnoidal space. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "hypendymal cell" ; rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023181" ; rdfs:subClassOf obo:CL_0000710, obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002139 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000015658 ] . obo:CL_4023187 obo:IAO_0000115 "A neuron with a small cell body that is located in a koniocellular layer of the lateral geniculate nucleus (LGN)." ; terms:contributor ; oboInOwl:hasDbXref "NIFEXT:44" ; oboInOwl:hasExactSynonym "K cell" ; a owl:Class ; rdfs:comment "In adult monkeys, koniocellular cells can be distinguished from parvocellular and magnocellular of the LGN by their expression of calbindin, the alpha subunit of type II calmodulin-dependent protein kinase, and the gamma subunit of protein kinase C." ; rdfs:label "koniocellular cell" ; rdfs:subClassOf obo:CL_0012001, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0013615 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0013615 ] ) ] . obo:CL_4023188 obo:IAO_0000115 "A retinal ganglion cell that originate in the ganglion cell layer of the retina, and project to the parvocellular layers of the lateral geniculate nucleus (LGN). These cells are known as midget retinal ganglion cells due to the small sizes of their dendritic trees and cell bodies." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0001-7655-4833" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment """There are midget bipolar cells of retina and midget ganglion cells of retina and they are not the same: Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances from the fovea (retinal eccentricity of 4.5mm as compared to 12 mm). Midget ganglion cells (MGC) have larger dendritic fields (here seen at 8 mm) as they increase in eccentricity.""" ; rdfs:label "midget ganglion cell of retina" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0013607 ] . obo:CL_4023189 obo:IAO_0000115 "A retinal ganglion cell located in the ganglion cell layer of the retina. This cell projects to magnocellular cells in the lateral geniculate nucleus (LGN). They have large cell bodies and extensive, branching dendritic networks that contribute to their large receptive fields." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor "https://orcid.org/0000-0001-7258-9596", "https://orcid.org/0000-0001-7655-4833" ; oboInOwl:hasRelatedSynonym "M cell", "M ganglion cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "These cells should not be confused with M1-M14 retinal ganglion cells described in PMID:16626866 which refer to a different classification of retinal ganglion cells." ; rdfs:label "parasol ganglion cell of retina" ; rdfs:subClassOf obo:CL_0000740, [ a owl:Restriction ; owl:onProperty obo:RO_0013001 ; owl:someValuesFrom obo:UBERON_0013606 ] . obo:CL_4028001 obo:IAO_0000115 "Any capillary endothelial cell that is part of a lung." ; terms:contributor ; oboInOwl:creation_date "2021-11-23T02:31:40Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "lung capillary endothelial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "pulmonary capillary endothelial cell" ; rdfs:subClassOf obo:CL_0002144, obo:CL_2000016, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016405 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002144 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:CL_4028002 obo:IAO_0000115 "An alveolar capillary endothelial cell that is located distally to alveolar capillary type 2 endothelial cells." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2021-11-23T03:23:53Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "capillary 1 cell", "general capillary cell" ; oboInOwl:hasRelatedSynonym "CAP1", "gCAP" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "alveolar capillary type 1 endothelial cell" ; rdfs:subClassOf obo:CL_4028001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002299 ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" . obo:CL_4028003 obo:IAO_0000115 "An alveolar capillary endothelial cell that is located proximally to alveolar capillary type 1 endothelial cells and in close apposition to alveolar type 1 epithelial cells (also known as type I pneumocytes)." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2021-11-23T03:23:53Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "CD34hi endothelial cells", "Car4+ capillary endothelial cell", "aerocyte", "alveolar capillary cell", "capillary 2 cell" ; oboInOwl:hasRelatedSynonym "aCAP" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "alveolar capillary type 2 endothelial cell" ; rdfs:subClassOf obo:CL_4028001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002299 ] . obo:CL_4028004 obo:IAO_0000115 "A pulmonary interstitial fibroblast that is part of the alveolus and contains lipid droplets." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , , , ; oboInOwl:creation_date "2021-12-09T15:34:13Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "alveolar fibroblast", "alveolar fibroblast 1", "lipid interstitial cell", "lipofibroblast", "matrix fibroblast 1", "pulmonary lipofibroblast" ; oboInOwl:hasRelatedSynonym "AF1" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The marker set AOC3, LUM can identify the Human cell type alveolar type 1 fibroblast cell in the lung with a confidence of 0.70 (NS-Forest FBeta value)." ; rdfs:label "alveolar type 1 fibroblast cell" ; rdfs:subClassOf obo:CL_0002241, obo:CL_0002553, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002299 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000002 ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" . obo:CL_4028006 obo:IAO_0000115 "A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:creation_date "2021-12-09T15:53:21Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "adventitial fibroblast", "alveolar fibroblast", "matrix fibroblast 2", "mesenchymal alveolar niche cell", "type-2 associated stromal cell" ; oboInOwl:hasExactSynonym "alveolar type 2 fibroblast cell" ; oboInOwl:hasRelatedSynonym "AF2", "AdvF", "MANC" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The marker set SCARA5, CD248 can identify the Human cell type alveolar adventitial fibroblast in the lung with a confidence of 0.85 (NS-Forest FBeta value)." ; rdfs:label "alveolar adventitial fibroblast" ; rdfs:subClassOf obo:CL_0002241, obo:CL_0002553, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002299 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000001 ] . obo:CL_4029001 obo:IAO_0000115 "A cell that supports the development of a gamete by providing it cytoplasmic material (including entire organelles) by direct cross-membrane channels (del Pino, 2021)." ; terms:contributor ; terms:date "2022-06-08T15:29:54Z"^^xsd:dateTime ; oboInOwl:hasDbXref "BTO:0000953" ; oboInOwl:hasOBONamespace "cell" ; a owl:Class ; rdfs:label "gamete-nursing cell" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_4029002 obo:IAO_0000115 "A gamete-nursing cell that derives from a germline cell (del Pino, 2021)." ; terms:contributor ; terms:date "2022-06-08T15:32:29Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "cell" ; a owl:Class ; rdfs:comment "Nurse cells were first described in insects, but recent works suggest they also exist in some mammals (Lei and Spradling, 2016)." ; rdfs:label "germline-derived nurse cell" ; rdfs:subClassOf obo:CL_0000039, obo:CL_4029001 . obo:CL_4029003 obo:IAO_0000115 "A gamete-nursing cell that derives from the somatic tissues of the gonad (del Pino, 2021)." ; terms:contributor ; terms:date "2022-06-08T15:38:03Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "cell" ; a owl:Class ; rdfs:comment "We follow what seems to be a common usage in the literature, which is to reserve the term “nurse cell” proper to cells from the germ line, hence the label “nurse-like”. This term encompasses pyriform cells described in reptiles, bird, and amphibians (del Pino, 2021); it does not encompass mammalian Sertoli cells, which do not appear to transfer cytoplasmic material to spermatogonia (França et al., 2016)." ; rdfs:label "somatic nurse-like cell" ; rdfs:subClassOf obo:CL_4029001 . obo:CL_4030000 obo:IAO_0000115 "A melanocyte located in the vascular uvea and involved in photoprotection, regulation of oxidative damage and immune responses." ; oboInOwl:creation_date "2022-01-20T12:59:06Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "uveal melanocyte" ; a owl:Class ; rdfs:comment "Cellular functions and extracellular interactions of choroidal melanocytes are distinct to skin melanocytes. They might have both neuroectodermal as well as mesectodermal origins." ; rdfs:label "choroidal melanocyte" ; rdfs:subClassOf obo:CL_0000148, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001768 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001768 ] ) ] . obo:CL_4030001 obo:IAO_0000115 "A stromal cell that is part of the thymus." ; terms:date "2022-07-08T11:39:38Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "thymic stromal cell" ; a owl:Class ; rdfs:label "stromal cell of thymus" ; rdfs:subClassOf obo:CL_0000499, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] ) ] . obo:CL_4030002 obo:IAO_0000115 "An alpha-beta memory T cell with the phenotype CD45RA-positive." ; oboInOwl:creation_date "2022-02-01T13:04:46Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "TEMRA", "effector memory RA T cell" ; oboInOwl:hasExactSynonym "TEMRA cell", "terminally differentiated effector memory CD45RA+ T cells", "terminally differentiated effector memory cells re-expressing CD45RA" ; a owl:Class ; rdfs:label "effector memory CD45RA-positive, alpha-beta T cell, terminally differentiated" ; rdfs:subClassOf obo:CL_0000791 . obo:CL_4030003 obo:IAO_0000115 "A cell that makes up the loose connective tissue of the thymus." ; terms:date "2022-07-08T11:48:36Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "thymic interstitial cell" ; a owl:Class ; rdfs:label "interstitial cell of thymus" ; rdfs:subClassOf obo:CL_4030001 . obo:CL_4030004 obo:IAO_0000115 "A large epithelial cell found in the thymus. This cell type may internalize thymocytes through extensions of plasma membrane. The cell surface and cytoplasmic vacuoles of a thymic nurse cell express MHC Class I and MHC Class II antigens. The interaction of these antigens with a developing thymocyte determines whether the thymocyte undergoes positive or negative selection." ; terms:contributor ; terms:date "2022-02-18T12:43:20Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "thymic nurse cell" ; rdfs:subClassOf obo:CL_0002293 . obo:CL_4030005 obo:IAO_0000115 "A renal beta-intercalated cell that is part of the cortical collecting duct. The medullary collecting duct does not contain the renal beta-intercalated cell type." ; terms:date "2022-09-14T16:19:11Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "B-IC", "kidney collecting duct intercalated cell type B" ; a owl:Class ; rdfs:label "kidney collecting duct beta-intercalated cell" ; rdfs:subClassOf obo:CL_0002201, obo:CL_1000715 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002201 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004203 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-cortical-collecting-duct/v1.3/assets/2d-ftu-kidney-cortical-collecting-duct.png" . obo:CL_4030006 obo:IAO_0000115 "An epithelial cell that is part of the fallopian tube that secretes mucus and oviduct-specific products in response to hormonal stimulation from estrogen and luteinizing hormone. This fallopian tube secretory cell is similar in height to the ciliated cell, but typically exhibits a more narrow, columnar shape. Its nucleus is ovoid and oriented perpendicular to the cell's long axis, with denser chromatin and a smaller nucleolus compared to the ciliated cell." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-03-03T10:39:31Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "oviduct secretory epithelial cell" ; oboInOwl:hasExactSynonym "uterine tube secretory epithelial cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The other cell types of the fallopian tube epithelium include the ciliated cell and the intercalary cell, or peg cell. The fallopian tube secretory epithelial cell type has been implicated as a source of high-grade serous ovarian carcinoma." ; rdfs:label "fallopian tube secretory epithelial cell" ; rdfs:subClassOf obo:CL_1001591, obo:CL_4052019 . obo:CL_4030007 obo:IAO_0000115 "A multi-ciliated epithelial cell that is part of the fallopian tube, mainly found on the apex of the mucosal folds. This cell exhibits a columnar shape with an oval nucleus and is characterized by the presence of cilia on its surface. The coordinated beating of these cilia, together with peristaltic contractions, contributes to the self-propulsion of spermatozoa, the transport of ovum during ovulation and the transport of the fertilized ovum to the intramural fallopian tube." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-03-08T12:40:19Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "oviduct ciliated cell" ; oboInOwl:hasExactSynonym "fallopian tube ciliated cell", "fallopian tube multiciliated cell", "uterine tube ciliated epithelial cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "fallopian tube multiciliated epithelial cell" ; rdfs:subClassOf obo:CL_0005012, obo:CL_4052018, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007589 ] . obo:CL_4030008 obo:IAO_0000115 "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the pronephros." ; terms:contributor ; terms:date "2022-03-11T14:38:32Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "pronephric glomerular visceral epithelial cell" ; a owl:Class ; rdfs:label "pronephric podocyte" ; rdfs:subClassOf obo:CL_0000653, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002120 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000653 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002120 ] ) ] . obo:CL_4030009 obo:IAO_0000115 "A brush border cell that is part of segment 1 (S1) of the proximal tubule epithelium, located in the renal cortex." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:date "2022-05-10T13:14:00Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "epithelial cell of segment 1 of proximal tubule" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "epithelial cell of proximal tubule segment 1" ; rdfs:subClassOf obo:CL_1000838, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004196 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004196 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005903 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" . obo:CL_4030010 obo:IAO_0000115 "A brush border cell that is part of segment 2 (S2) of the proximal tubule epithelium, located in the renal cortex. In addition to its reabsorptive functions, it is also specialized in the secretion of organic anions and cations, including para-aminohippurate." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:date "2022-05-10T13:26:13Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "epithelial cell of segment 2 of proximal tubule" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "epithelial cell of proximal tubule segment 2" ; rdfs:subClassOf obo:CL_1000838, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004197 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004197 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005903 ] ) ] . obo:CL_4030011 obo:IAO_0000115 "A brush border cell that is part of segment 3 (S3) of the proximal tubule epithelium, which extends from the medullary rays of the renal cortex into the outer medulla." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:date "2022-05-10T13:31:06Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "epithelial cell of segment 3 of proximal tubule" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The epithelial cell of proximal tubule segment 3 operates under relatively hypoxic conditions and is particularly susceptible to ischemic injury." ; rdfs:label "epithelial cell of proximal tubule segment 3" ; rdfs:subClassOf obo:CL_0002307, obo:CL_1000839 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001290 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005903 ] ) ] . obo:CL_4030012 obo:IAO_0000115 "Epithelial cell of the descending thin limb of the short loop (cortical) nephron limited to the outer medulla (mainly inner strip). It is known in some mammalian species that the short descending limb of the loop of Henle selectively expresses the serine protease Corin, the homeobox TF Uncx, and the urea channel Slc14a2." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-05-13T11:00:29Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "epithelial cell of the descending thin limb of the short loop of Henle" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney loop of Henle short descending thin limb epithelial cell" ; rdfs:subClassOf obo:CL_0000076, obo:CL_1001111, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005099 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005099 ] ) ] . obo:CL_4030013 obo:IAO_0000115 "Epithelial cell of the descending thin limb of the long loop (juxtamedullary) nephron that spans the outer medulla (inner stripe). It is known in some mammalian species that the long descending limb of the loop of Henle in the outer medulla selectively expresses the secreted activin-antagonist protein follistatin (Fst), the GPI-linked adhesion protein Cdh13, and the protein kinase Stk32a." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:date "2022-05-13T11:11:07Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "epithelial cell of the outer medulla of the long descending limb of the loop of Henle" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney loop of Henle long descending thin limb outer medulla epithelial cell" ; rdfs:subClassOf obo:CL_1001111, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005100 ] . obo:CL_4030014 obo:IAO_0000115 "Epithelial cell of the descending thin limb of the long loop (juxtamedullary) nephron that spans the inner medulla. It is known in some mammalian species that the long descending limb of the loop of Henle in the inner medulla selectively expresses the nuclear receptor Nr2e3, the Ig kappa chain Igkc, and the secreted protein dermokine (Dmkn). SLC14A2, which expresses a urea transporter, is also expressed in the inner medulla." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:date "2022-05-13T11:16:54Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "epithelial cell of the inner medulla of the long descending limb of the loop of Henle" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney loop of Henle long descending thin limb inner medulla epithelial cell" ; rdfs:subClassOf obo:CL_1001111, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005100 ] . obo:CL_4030015 obo:IAO_0000115 "A renal alpha-intercalated cell that is part of the collecting duct of the renal tubule." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2022-05-31T11:15:10Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "kidney collecting duct intercalated cell type A" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney collecting duct alpha-intercalated cell" ; rdfs:subClassOf obo:CL_0005011, obo:CL_1001432 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005011 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001232 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-cortical-collecting-duct/v1.3/assets/2d-ftu-kidney-cortical-collecting-duct.png" . obo:CL_4030016 obo:IAO_0000115 "An epithelial cell located in the early distal convoluted tubule." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:date "2022-06-21T12:47:48Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "DCT1 cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "epithelial cell of early distal convoluted tubule" ; rdfs:subClassOf obo:CL_1000849, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005101 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005101 ] ) ] . obo:CL_4030017 obo:IAO_0000115 "An epithelial cell located in the late distal convoluted tubule." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:date "2022-06-21T13:51:46Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "DCT2 cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Although mineralocorticoid receptors are expressed throughout the entire [distal convoluted tubule], the DCT2 is sensitive to the actions of aldosterone, because it expresses an enzyme called 11-β hydroxysteroid dehydrogenase 2 (11-βHSD2)" ; rdfs:label "epithelial cell of late distal convoluted tubule" ; rdfs:subClassOf obo:CL_1000849, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005102 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005102 ] ) ] . obo:CL_4030018 obo:IAO_0000115 "A renal principal cell located in the connecting tubule." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:date "2022-06-27T15:25:10Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney connecting tubule principal cell" ; rdfs:subClassOf obo:CL_0005009, obo:CL_1000768 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005097 ] ) ] . obo:CL_4030019 obo:IAO_0000115 "A renal intercalated cell that is part of the renal connecting tubule." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:date "2022-06-29T11:25:22Z"^^xsd:dateTime ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney connecting tubule intercalated cell" ; rdfs:subClassOf obo:CL_0005010, obo:CL_1000768 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005010 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005097 ] ) ] . obo:CL_4030020 obo:IAO_0000115 "A renal alpha-intercalated cell that is part of the renal connecting tubule." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:date "2022-06-29T12:48:43Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "connecting tubule A-IC", "kidney connecting tubule intercalated cell type A" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney connecting tubule alpha-intercalated cell" ; rdfs:subClassOf obo:CL_0005011, obo:CL_4030019 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005011 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005097 ] ) ] . obo:CL_4030021 obo:IAO_0000115 "A renal beta-intercalated cell that is part of the renal connecting tubule." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:date "2022-06-29T14:31:18Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "connecting tubule B-IC", "kidney connecting tubule intercalated cell type B" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney connecting tubule beta-intercalated cell" ; rdfs:subClassOf obo:CL_0002201, obo:CL_4030019 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002201 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005097 ] ) ] . obo:CL_4030022 obo:IAO_0000115 "A fibroblast that is located in the renal medulla interstitium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:date "2022-07-05T12:13:40Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "kidney medullary fibroblast" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "It has been noted that inner medullary fibroblasts are involved in the regulation of water and electrolyte homeostasis." ; rdfs:label "renal medullary fibroblast" ; rdfs:subClassOf obo:CL_1000682, obo:CL_1000692 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005211 ] ) ] . obo:CL_4030023 obo:IAO_0000115 "A hillock cell that is located in respiratory epithelium. In some mammalian species, this cell type has been noted to express KRT13 and KRT4 and is postulated to play a role in squamous barrier function and immunomodulation." ; terms:date "2022-06-06T08:31:09Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "hillock cell of respiratory tract", "respiratory hillock cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "respiratory tract hillock cell" ; rdfs:subClassOf obo:CL_0002368, obo:CL_4030024 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4030024 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004802 ] ) ] . obo:CL_4030024 obo:IAO_0000115 "An epithelial, transitional cell type between basal and secretory; located in stratified, non-ciliated structures (called hillocks) with high cell turnover in epithelium. In some mammalian species, this cell type has been noted to express KRT13 and is postulated to play a role in squamous barrier function and immunomodulation." ; terms:date "2022-06-24T14:52:24Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "hillock cell" ; rdfs:subClassOf obo:CL_0000066 . obo:CL_4030025 obo:IAO_0000115 "A fibroblast that is located in the renal cortical interstitium." ; terms:date "2022-07-05T15:50:17Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "kidney cortical fibroblast" ; a owl:Class ; rdfs:comment "Renal cortical fibroblasts have key roles in mediating intercellular communication with neighboring/infiltrating cells and extracellular matrix and maintenance of renal tissue architecture. They additionally have an endocrine function in the production of epoetin." ; rdfs:label "renal cortical fibroblast" ; rdfs:subClassOf obo:CL_1000681, obo:CL_1000692 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005270 ] ) ] . obo:CL_4030026 obo:IAO_0000115 "An enterocyte of the human intestine expressing bestrophin-4 (BEST4) calcium-activated ion channels." ; terms:date "2022-09-07T12:34:20Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "BEST4+ enterocyte" ; rdfs:subClassOf obo:CL_0000584, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_Q8NFU0 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_Q8NFU0 ] ) ] . obo:CL_4030027 obo:IAO_0000115 "An amacrine cell that uses GABA as a neurotransmitter." ; terms:date "2022-10-17T12:35:11Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "amacrine cell, GABAergic" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "GABAergic amacrine cell" ; rdfs:subClassOf obo:CL_0000561, obo:CL_0011005 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000561 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ) ] . obo:CL_4030028 obo:IAO_0000115 "An amacrine cell that uses glycine as a neurotransmitter." ; terms:date "2022-10-17T12:40:06Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "amacrine cell, glycinergic" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "glycinergic amacrine cell" ; rdfs:subClassOf obo:CL_0000561, obo:CL_1001509 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000561 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061537 ] ) ] . obo:CL_4030029 obo:IAO_0000115 "A lymphocyte located in blood." ; terms:date "2022-11-04T14:40:00Z"^^xsd:dateTime ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:label "blood lymphocyte" ; rdfs:subClassOf obo:CL_0000542, obo:CL_2000001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000542 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] . obo:CL_4030030 obo:IAO_0000115 "A blood lymphocyte located in the flowing, circulating blood of the body." ; terms:date "2022-11-14T10:08:14Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "peripheral blood lymphocyte" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/pull/1725" ; rdfs:subClassOf obo:CL_4030029, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0013755 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0013756 ] . obo:CL_4030031 obo:IAO_0000115 "Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. \"Interstitial cell\" is a morphological term and refers to a variety of cells with differing origins and phenotypes." ; terms:date "2022-11-30T14:35:08Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "interstitial cell" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005169 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005169 ] ) ] . obo:CL_4030032 obo:IAO_0000115 "An interstitial cell that is part of a cardiac valve leaflet. Along with valve endothelial cells, a valve interstitial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:date "2022-12-06T14:18:45Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "VIC", "cardiac valve interstitial cell", "valvular interstitial cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Activated valve interstitial cells undergo continual turn over into deactivated fibroblasts and other cell fates (such as apoptosis)." ; rdfs:label "valve interstitial cell" ; rdfs:subClassOf obo:CL_0000151, obo:CL_1000147, obo:CL_4030031, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070278 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4030031 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000946 ] ) ] . obo:CL_4030033 obo:IAO_0000115 "An endothelial cell that lines a surface of a cardiac valve leaflet. Along with valve interstitial cells, a valve endothelial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes." ; terms:date "2022-12-09T11:58:49Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "VEC", "valvular endothelial cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "At least in some mammalian species, a valve endothelial cell expresses CD31. Valve endothelial cells can undergo an endothelial to mesenchymal transition to acquire a fibroblast or myofibroblast phenotype that leads to changes in the microenvironmental signals and facilitates tissue regeneration." ; rdfs:label "valve endothelial cell" ; rdfs:subClassOf obo:CL_0010008, obo:CL_1000147 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000946 ] ) ] . obo:CL_4030034 obo:IAO_0000115 "A multiciliated epithelial cell located in the respiratory tract epithelium, characterized by a columnar shape and motile cilia on its apical surface. This cell develops through a highly orchestrated process, transitioning from a basal progenitor via an intermediate deuterosomal cell stage that generates centrioles essential for ciliogenesis." ; terms:date "2023-01-25T11:06:01Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "ciliated cell of the respiratory tract", "respiratory ciliated cell", "respiratory multiciliated cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "respiratory tract multiciliated cell" ; rdfs:subClassOf obo:CL_0002368, obo:CL_0005012, [ a owl:Restriction ; owl:onProperty obo:RO_0002207 ; owl:someValuesFrom obo:CL_4033044 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004802 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0031514 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0010007 ] ) ] . obo:CL_4030035 obo:IAO_0000115 "A dental pulp cell that possesses stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation." ; terms:date "2023-01-10T14:02:02Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "DPSC" ; a owl:Class ; rdfs:label "dental pulp stem cell" ; rdfs:subClassOf obo:CL_0000034, obo:CL_0002148 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000034 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001754 ] ) ] . obo:CL_4030036 obo:IAO_0000115 "A spermatid in an early stage of maturation that has a round morphology and is transcriptionally active." ; terms:date "2023-02-01T13:56:00Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "round spermatid" ; a owl:Class ; rdfs:label "early spermatid" ; rdfs:subClassOf obo:CL_0000018, _:genid17936, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007286 ] . obo:CL_4030037 obo:IAO_0000115 "A spermatid in a late stage of maturation that has an elongated morphology and is transcriptionally inert when the acrosome is fully developed." ; terms:date "2023-02-01T14:02:15Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "elongated spermatid" ; a owl:Class ; rdfs:label "late spermatid" ; rdfs:subClassOf obo:CL_0000018, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000079 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_4030036 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007286 ] . obo:CL_4030038 obo:IAO_0000115 "A CD24-positive, CD-133-positive, vimentin-positive cell found scattered throughout a renal proximal tubule and that may participate in tubular regeneration. Compared to other proximal tubular cell types, this cell contains less cytoplasm, fewer mitochondria and no brush border." ; terms:date "2023-03-07T14:17:39Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "CD133+CD24+CD106- tubular cell", "CD24+CD133+ tubular cell", "CD24-positive tubular cell" ; a owl:Class ; rdfs:comment "After acute tubular injury, this cell type becomes more numerous. In healthy rat kidneys, this cell is not detectable, whereas after unilateral ureteral obstruction (renal injury), it may appear de novo, arguing against the notion that this cell type represents a pre-existing progenitor cell population. In at least one study, data indicate that this cell type represents transiently dedifferentiated tubular cells involved in regeneration." ; rdfs:label "CD24-positive, CD-133-positive, vimentin-positive proximal tubular cell" ; rdfs:subClassOf obo:CL_0002306, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008404 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001786 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017298 ] . obo:CL_4030039 obo:IAO_0000115 "An extratelencephalic-projecting glutamatergic cortical neuron that is morphologically-defined with a large, spindle-shaped cell body, thick bipolar dendrites with limited branching and a moderate density of spines, and often an axon initial segment that emanates from the side of the cell body. This cell type is associated with markers POU3F, BMP3 and ITGA4." ; terms:date "2023-05-25T07:29:21Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "VEN" ; a owl:Class ; rdfs:comment "In humans, a von Economo neuron is restricted to layer 5 of the anterior cingulate, frontoinsular, and medial frontopolar regions of cerebral cortex, while in some other species it is also found in the frontal and occipital poles and may not be restricted to layer 5." ; rdfs:label "von Economo neuron" ; rdfs:subClassOf obo:CL_4023009, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070006 ] . obo:CL_4030040 obo:IAO_0000115 "A multi-ciliated cell of the endometrial epithelium. This cell is characterized by the presence of 9+2 motile cilia on its apical surface, which facilitates the movement of mucus across the endometrial surface." ; terms:date "2023-02-09T11:25:14Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "ciliated cell of the uterus", "uterine ciliated cell" ; oboInOwl:hasExactSynonym "ciliated cell of the endometrium", "endometrial ciliated epithelial cell", "endometrium ciliated epithelial cell" ; a owl:Class ; rdfs:comment "In human samples, the expression of FOXJ1 protein, a regulator for motile cilia with epithelial lineage identity, has been noted." ; rdfs:label "endometrial multiciliated epithelial cell" ; rdfs:subClassOf obo:CL_0002149, obo:CL_0005012, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004811 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0097729 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004811 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0097729 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0010007 ] ) ] . obo:CL_4030041 obo:IAO_0000115 "A ciliated cell of the endometrial luminal epithelium. This cell is characterized by the presence of motile cilia on its apical surface." ; terms:date "2023-02-09T11:34:42Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "luminal endometrial ciliated epithelial cell" ; a owl:Class ; rdfs:label "luminal endometrial multiciliated epithelial cell" ; rdfs:subClassOf obo:CL_4030040, obo:CL_4052050 . obo:CL_4030042 obo:IAO_0000115 "A ciliated cell of the endometrial glandular epithelium. This cell is characterized by the presence of motile cilia on its apical surface." ; terms:date "2023-02-09T11:37:30Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "glandular endometrial ciliated epithelial cell" ; a owl:Class ; rdfs:label "glandular endometrial multiciliated epithelial cell" ; rdfs:subClassOf obo:CL_0009084, obo:CL_4030040 . obo:CL_4030043 obo:IAO_0000115 "A DRD1-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." ; terms:date "2023-06-02T14:05:03Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "D1-matrix", "D1M", "matrix D1-MSN" ; a owl:Class ; rdfs:comment "In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways." ; rdfs:label "matrix D1 medium spiny neuron" ; rdfs:subClassOf obo:CL_0002613, obo:CL_4023026, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0027368 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005382 ] ) ] ] . obo:CL_4030044 a owl:ObjectProperty ; rdfs:label "has_not_completed" . obo:CL_4030045 obo:IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 ?Y" ; a owl:ObjectProperty ; rdfs:label "lacks_part" . obo:CL_4030046 obo:IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" ; a owl:ObjectProperty ; rdfs:label "lacks_plasma_membrane_part" . obo:CL_4030047 obo:IAO_0000115 "A DRD2-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." ; terms:date "2023-06-02T14:40:25Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "D2-matrix", "D2M", "matrix D2-MSN" ; a owl:Class ; rdfs:comment "In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways." ; rdfs:label "matrix D2 medium spiny neuron" ; rdfs:subClassOf obo:CL_0002613, obo:CL_4023029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0027368 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005382 ] ) ] ] . obo:CL_4030048 obo:IAO_0000115 "A DRD1-expressing medium spiny neuron that is part of a striosome of dorsal striatum." ; terms:date "2023-06-02T14:50:43Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "striosome D1 medium spiny neuron" ; oboInOwl:hasRelatedSynonym "D1-striosome", "D1S", "striosome D1-MSN" ; a owl:Class ; rdfs:comment "In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons." ; rdfs:label "striosomal D1 medium spiny neuron" ; rdfs:subClassOf obo:CL_0002613, obo:CL_4023026, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0027371 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005382 ] ) ] ] . obo:CL_4030049 obo:IAO_0000115 "A DRD2-expressing medium spiny neuron that is part of a striosome of dorsal striatum." ; terms:date "2023-06-02T15:03:08Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "striosome D2 medium spiny neuron" ; oboInOwl:hasRelatedSynonym "D2-striosome", "D2S", "striosome D2-MSN" ; a owl:Class ; rdfs:comment "In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons." ; rdfs:label "striosomal D2 medium spiny neuron" ; rdfs:subClassOf obo:CL_0002613, obo:CL_4023029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0027371 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005382 ] ) ] ] . obo:CL_4030050 obo:IAO_0000115 "A medium spiny neuron that expresses both DRD1 and DRD2 and is part of an extra-striosomal part of dorsal striatum." ; terms:date "2023-06-02T15:19:45Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "D1/2", "D1/D2 hybrid", "D1/D2-hybrid MSN", "hybrid D1/2 cell type" ; a owl:Class ; rdfs:comment "It has been noted in non-human primate species that the D1/D2-hybrid medium spiny neuron (D1/2) cell type shows the same amount of DRD1 expression as nearby D1 medium spiny neurons but far less DRD2 expression compared to nearby D2 medium spiny neurons. In Rhesus macaques, RXFP1 has been noted as a highly specific marker gene for the D1/2 cell type. The D1/2 cell type has also been described as having characteristics similar to a novel medium spiny neuron described in rodents (D1H or eccentric spiny projection neuron). Although an extrastriosomal cell type, the D1/2 cell type had been noted to express many of the genes associated with striosome, suggesting a possible homology to ‘‘exo-patch’’ cells." ; rdfs:label "D1/D2-hybrid medium spiny neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0002613, obo:CL_1001474, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005382 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001175 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001177 ] . obo:CL_4030051 obo:IAO_0000115 "A DRD1-expressing medium spiny neuron that is part of a nucleus accumbens shell or olfactory tubercle." ; terms:date "2023-06-14T13:03:50Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "NAc shell and OT D1 medium spiny neuron" ; oboInOwl:hasRelatedSynonym "D1Sh", "NAc shell and OT D1-MSN" ; a owl:Class ; rdfs:comment "In Rhesus macaques, both nucleus accumbens shell and olfactory tubercle D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: GREB1L, ARHGAP6, and GRIA4." ; rdfs:label "nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0002613, obo:CL_1001474, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005403 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001175 ] . obo:CL_4030052 obo:IAO_0000115 "A DRD2-expressing medium spiny neuron that is part of a nucleus accumbens shell or olfactory tubercle." ; terms:date "2023-06-14T13:27:51Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "NAc shell and OT D2 medium spiny neuron" ; oboInOwl:hasRelatedSynonym "D2Sh", "NAc shell and OT D2-MSN", "nucleus accumbens shell and olfactory tubercle D2-MSN" ; a owl:Class ; rdfs:comment "In Rhesus macaques, both nucleus accumbens shell and olfactory tubercle D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: GREB1L, ARHGAP6, and GRIA4." ; rdfs:label "nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0002613, obo:CL_1001474, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005403 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001177 ] . obo:CL_4030053 obo:IAO_0000115 "A DRD1-expressing, medium spiny neuron-like granule cell that is part of an Island of Calleja." ; terms:date "2023-06-14T13:37:45Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "D1-ICj" ; a owl:Class ; rdfs:comment "In Rhesus macaques, the Island of Calleja granule cell type has been noted to have enriched gene expression of CPNE4." ; rdfs:label "Island of Calleja granule cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000120, obo:CL_0002613, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001881 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005403 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001175 ] . obo:CL_4030054 obo:IAO_0000115 "A DRD1-expressing medium spiny neuron that is part of dense, RXFP1-positive cell islands throughout the nucleus accumbens, putamen, and near the adjacent septal nuclei." ; terms:date "2023-06-14T14:46:08Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "RXFP1-positive island D1-medium spiny neuron" ; oboInOwl:hasRelatedSynonym "D1-NUDAP" ; a owl:Class ; rdfs:comment "Regarding the abbreviation D1-NUDAP, NUDAP stands for \"neurochemically unique domains in the accumbens and putamen\". In Rhesus macaques, the RXFP1-positive interface island D1-medium spiny neuron (D1-NUDAP) has been noted to have upregulation of OPRM1 compared to DRD1-expressing medium spiny neurons located outside of the D1-exclusive island and in Islands of Calleja. Kappa-opioid receptor gene (OPRK1) has been noted to be absent from D1-NUDAP cells. Many striosome-specific markers have been noted to be upregulated in D1-NUDAP cells, including KCNIP1, KCNT1, KHDRBS3, and BACH2. PDYN, an acknowledged D1-striosome marker gene, has also been noted to be expressed in D1-NUDAPs. D1-NUDAPs also express some genes found to be selectively expressed in the matrix, including STXBP6, GDA, and SEMA3E. Gene enrichment analysis has revealed that D1-NUDAP neurons express genes that have been implicated in drug addiction and many other functions." ; rdfs:label "RXFP1-positive interface island D1-medium spiny neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0002613, obo:CL_1001474, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005403 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001175 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001666 ] . obo:CL_4030055 obo:IAO_0000115 "A urothelial cell that is part of the regenerative layer(s) of cells directly superficial to basal cells in urothelium. The layer of intermediate cells in the urothelium ranges from one to several layers thick depending on the species with intermediate cells attached to adjacent cell layers and one another via desmosomes." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor "https://orcid.org/0000-0003-3065-9183" ; terms:date "2023-06-16T07:53:43Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:84155" ; oboInOwl:hasExactSynonym "urothelial intermediate cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "It has been noted in at least some mammalian species that the urothelial intermediate cell type is similar to basal cells by expressing CK17 and (unlike umbrella cells) p63 but is positive for uroplakins (UPK) and negative for CK5. Urothelial intermediate cells have also been noted to be larger in diameter than urothelial basal cells." ; rdfs:label "intermediate cell of urothelium" ; rdfs:subClassOf obo:CL_0000731 . obo:CL_4030056 obo:IAO_0000115 "A urothelial cell that is terminally differentiated and part of the urothelial apical surface that forms the high-resistance barrier of urothelium. Umbrella cells have been described as the largest of urothelial cell types, highly polarized, and, in some species, multinucleated. In the relaxed state, these cells form a dome-shaped structure at the apical pole and can also cover multiple underlying intermediate cells, leading to the name umbrella cells. In contrast, these cells flatten when the bladder is filled." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor "https://orcid.org/0000-0003-3065-9183" ; terms:date "2023-06-16T07:59:43Z"^^xsd:dateTime ; oboInOwl:hasDbXref "FMA:84149" ; oboInOwl:hasExactSynonym "facet cell of urothelium", "superficial cell of urothelium" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Umbrella cells are attached to sub-superficial cell layers via desmosomes, while tight junctions localized between superficial cells aid in forming a high-resistance barrier function. Another distinguishing feature of an umbrella cell type is the presence of subapical discoidal/fusiform-shaped vesicles contributing to the plasticity in urothelial cell surface area through a regulated process of endocytosis/exocytosis. It has been noted in at least some mammalian species that the urothelial umbrella cell type expresses UPK1A, UPK1B, UPK2 and UPK3A. Unlike intermediate and basal cells of the urothelium, CK17 is reported to be completely absent and p63 not expressed in umbrella cells." ; rdfs:label "umbrella cell of urothelium" ; rdfs:subClassOf obo:CL_0000731 . obo:CL_4030057 obo:IAO_0000115 "A medium spiny neuron that exhibits transcriptional divergence from direct and indirect spiny projection neurons, for example, enrichment in Casz1, Otof, Cacng5 and Pcdh8 noted in mice. Whilst in general medium spiny neurons have been found to be differentially distributed across the basal ganglia, the eccentric medium spiny neuron cell type has been found to be more evenly distributed throughout cerebral nuclei." ; terms:date "2023-06-23T14:59:36Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "eccentric spiny projection neuron" ; oboInOwl:hasRelatedSynonym "eSPN", "eccentric MSN", "eccentric SPN" ; a owl:Class ; rdfs:comment "The term “eccentric” is used in the name eccentric medium spiny neuron (MSN) due to the exhibited transcriptional divergence from canonical spiny projection neurons. It has been noted in at least one study that an eccentric MSN differs in expression from direct and indirect MSNs by 110 genes (more than the 68 that distinguished direct and indirect spiny projection neurons from each other) and expresses many genes that have little expression in the rest of the striatum. It also has been noted in at least one human study that most eccentric MSNs expressed only DRD1, but many in the basal ganglia co-expressed DRD1 and DRD2, suggesting regional specialization of a more broadly distributed cell type." ; rdfs:label "eccentric medium spiny neuron" ; rdfs:subClassOf obo:CL_1001474 . obo:CL_4030058 obo:IAO_0000115 "A macrophage that expresses the T cell receptor complex at the cell surface." ; terms:contributor ; terms:date "2023-09-26T12:27:14Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "T cell receptor positive macrophage", "TCR+ macrophage" ; oboInOwl:hasRelatedSynonym "TCR.macs" ; a owl:Class ; rdfs:label "TCR-positive macrophage" ; rdfs:subClassOf obo:CL_0000235, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042101 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000235 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042101 ] ) ] . obo:CL_4030059 obo:IAO_0000028 "L2/3 IT" ; obo:IAO_0000115 "A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found between cortical layer 2-4. This intratelencephalic-projecting glutamatergic neuron has thin-tufted apical dendrites and extends its axonal projection into L5 in the neocortex. This neuronal type has a hyperpolarised resting membrane potential. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', clusters L2/3 IT." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2023-10-10T14:10:21Z"^^xsd:dateTime ; oboInOwl:hasDbXref "ILX:0770156" ; oboInOwl:hasRelatedSynonym "L2/3 IT" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Hystorically, the L2/3 intratelencephalic projectic glutametergic neuron was known to have its soma in cortical layer 2/3. MERFISH data showed that this intratelencephalic-projecting glutametergic neuron can have its soma in layer 2/3, 4B, 4C. The position of the soma in layer 4b and 4C is less frequent for this neuronal type in comparison to cortical layer 2/3.", "The marker set ONECUT2, COL5A2 can identify the Human cell type L2/3 intratelencephalic projecting glutamatergic neuron in the neocortex with a confidence of 0.670149932 (NS-Forest FBeta value)." ; rdfs:label "L2/3 intratelencephalic projecting glutamatergic neuron" ; rdfs:subClassOf obo:CL_4023040, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8440000 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000065 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023040 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8440000 ] ) ] . obo:CL_4030060 obo:IAO_0000028 "L2 IT" ; obo:IAO_0000115 "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2." ; terms:contributor ; terms:date "2023-10-10T14:10:36Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "L2 IT" ; a owl:Class ; rdfs:label "L2 intratelencephalic projecting glutamatergic neuron" ; rdfs:subClassOf obo:CL_4023040, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005391 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023040 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005391 ] ) ] . obo:CL_4030061 obo:IAO_0000028 "L3 IT" ; obo:IAO_0000115 "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3." ; terms:contributor ; terms:date "2023-10-10T14:10:47Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "L3 IT" ; a owl:Class ; rdfs:label "L3 intratelencephalic projecting glutamatergic neuron" ; rdfs:subClassOf obo:CL_4023040, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005392 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023040 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005392 ] ) ] . obo:CL_4030062 obo:IAO_0000028 "L4/5 IT" ; obo:IAO_0000115 "An intratelencephalic-projecting glutamatergic with a soma located in cortical layer 4/5." ; terms:contributor ; terms:date "2023-10-10T14:11:04Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "L4/5 IT" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "L4/5 intratelencephalic projecting glutamatergic neuron" ; rdfs:subClassOf obo:CL_4023040, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8440001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023040 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8440001 ] ) ] . obo:CL_4030063 obo:IAO_0000028 "L4 IT" ; obo:IAO_0000115 "A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3-4. This neuron type can have a pyramidal, star-pyramidal or spiny stellate morphology and projects its output to L2/3 and L5A/B. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L4 IT." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2023-10-10T14:11:25Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "L4 IT" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Historically, the L4 intratelencephalic projectic glutametergic neuron was known to have its soma in cortical layer 4. MERFISH data showed that this intratelencephalic-projecting glutametergic neuron can also have its soma in layer 3.", "The marker set RORB, ST8SIA4 can identify the Human cell type L4 intratelencephalic projecting glutamatergic neuron in the neocortex with a confidence of 0.720108696 (NS-Forest FBeta value)." ; rdfs:label "L4 intratelencephalic projecting glutamatergic neuron" ; rdfs:subClassOf obo:CL_4023040, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005393 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000066 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023040 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005393 ] ) ] . obo:CL_4030064 obo:IAO_0000028 "L5 IT" ; obo:IAO_0000115 "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 5. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L5 IT." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2023-10-10T14:11:59Z"^^xsd:dateTime ; oboInOwl:hasDbXref "ILX:0770157" ; oboInOwl:hasRelatedSynonym "L5 IT" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "The marker set ARSJ, RORB, KCNK2 can identify the Human cell type L5 intratelencephalic projecting glutamatergic neuron in the neocortex with a confidence of 0.764261336 (NS-Forest FBeta value)." ; rdfs:label "L5 intratelencephalic projecting glutamatergic neuron" ; rdfs:subClassOf obo:CL_4023040, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005394 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000068 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023040 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005394 ] ) ] . obo:CL_4030065 obo:IAO_0000028 "L6 IT" ; obo:IAO_0000115 "A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L6 IT." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2023-10-10T14:12:23Z"^^xsd:dateTime ; oboInOwl:hasDbXref "ILX:0770158" ; oboInOwl:hasRelatedSynonym "L6 IT" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "The marker set LINC00507, THEMIS can identify the Human cell type L6 intratelencephalic projecting glutamatergic neuron in the neocortex with a confidence of 0.641695703 (NS-Forest FBeta value)." ; rdfs:label "L6 intratelencephalic projecting glutamatergic neuron" ; rdfs:subClassOf obo:CL_4023040, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005395 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000071 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023040 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005395 ] ) ] . obo:CL_4030066 obo:IAO_0000115 "An epithelial cell that is part of a ureteric bud. A ureteric bud cell has the potential to induce metanephric mesenchymal cells to proliferate and convert to epithelia that form renal tubules via: (1) the secretion of multiple diffusible growth factors that rescue renal progenitors from apoptosis and stimulate them to proliferate and (2) contact-dependent mechanisms that induce mesenchymal-epithelial conversion." ; terms:contributor "https://orcid.org/0000-0002-1425-877X" ; terms:date "2023-10-13T11:22:42Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "UB cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "ureteric bud cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000068, obo:CL_0002518, _:genid15717, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000084 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000084 ] ) ] . obo:CL_4030067 obo:IAO_0000115 "A near-projecting glutamatergic neuron with a soma found in cortical layer 5/6." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2023-11-17T11:35:06Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "L5/6 NP" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "The marker set NPSR1-AS1, TLL1 can identify the Human cell type L5/6 near-projecting glutamatergic neuron in the neocortex with a confidence of 0.899288218 (NS-Forest FBeta value)." ; rdfs:label "L5/6 near-projecting glutamatergic neuron" ; rdfs:subClassOf obo:CL_4023012, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8440002 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000069 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023012 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8440002 ] ) ] . obo:CL_4030068 obo:IAO_0000028 "L6 IT Car3" ; obo:IAO_0000115 "A transcriptomically distinct intratelencepalic-projecting glutamatergic neuron that expresses Car3 with a soma found in L6 . The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_cluster', L6 IT Car3." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2023-11-23T09:16:14Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "L6 IT Car3 glutamatergic neuron" ; oboInOwl:hasRelatedSynonym "L6 IT Car3", "L6 IT Car3 neuron", "L6-IT-Car3", "L6-IT-Car3 cell" ; a owl:Class ; rdfs:comment "The marker set SMYD1, THEMIS can identify the Human cell type L6 intratelencephalic projecting Car3 glutamatergic neuron in the neocortex with a confidence of 0.877752028 (NS-Forest FBeta value)." ; rdfs:label "L6 intratelencephalic projecting Car3 glutamatergic neuron" ; rdfs:subClassOf obo:CL_4030065, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000004919 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000072 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4030065 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000004919 ] ) ] . obo:CL_4032000 obo:IAO_0000115 "An epithelial cell of the urethra that has an expression profile similar to lung club cells. Club-like cells of the urethra epithelium are similar to lung club cells in their expression of SCGB1A1 and in their enrichment of immunomodulatory programs." ; obo:IAO_0000116 "The term \"club-like\" is used to disambiguate from club cells which CL defines as a type of bronchial epithelial cell. This seems to reflect common usage of club cell when used without location (club cell seems to mean bronchial club cell, unless it is proceded or preceded by something that says it is not bronchial). In the literature, the name \"club-like\" isn't used." ; terms:contributor ; oboInOwl:hasExactSynonym "club cell of the urethra epithelium", "club-like cell of the prostatic urethra epithelium", "prostate club cell" ; a owl:Class ; rdfs:comment "Club cells typically refer to bronchiolar exocrine cells found in the lungs. This cell type is given the name club cell due to their similarity to club cells in the lungs." ; rdfs:label "club-like cell of the urethral epithelium" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_1000296, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000014505 ] . obo:CL_4032001 obo:IAO_0000115 "A GABAergic interneuron located in the cerebral cortex that expresses reelin (rln)." ; terms:contributor , "http://orcid.org/0000-0001-5501-853X", "http://orcid.org/0000-0001-7476-6306" ; oboInOwl:hasExactSynonym "rln GABAergic cortical interneuron" ; a owl:Class ; rdfs:label "reelin GABAergic cortical interneuron" ; rdfs:subClassOf obo:CL_0010011, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000013879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000013879 ] ) ] . obo:CL_4033000 obo:IAO_0000115 "A(n) endothelial cell that is part of a(n) venule of lymph node." ; terms:contributor ; a owl:Class ; rdfs:label "endothelial cell of venule of lymph node" ; rdfs:subClassOf obo:CL_1000414, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410041 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410041 ] ) ] . obo:CL_4033001 obo:IAO_0000115 "A(n) endothelial cell that is part of a(n) arteriole of lymph node." ; terms:contributor ; a owl:Class ; rdfs:label "endothelial cell of arteriole of lymph node" ; rdfs:subClassOf obo:CL_1000412, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410042 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410042 ] ) ] . obo:CL_4033002 obo:IAO_0000115 "A(n) neuroendocrine cell that is part of a(n) epithelium of crypt of Lieberkuhn." ; terms:contributor ; a owl:Class ; rdfs:label "neuroendocrine cell of epithelium of crypt of Lieberkuhn" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000165, obo:CL_1001516, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011184 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000165 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011184 ] ) ] . obo:CL_4033003 obo:IAO_0000115 "A(n) myoepithelial cell that is part of a(n) bronchus submucosal gland." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "myoepithelial cell of bronchus submucosal gland" ; rdfs:subClassOf obo:CL_0000185, obo:CL_0002328, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410043 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000185 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410043 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" . obo:CL_4033004 obo:IAO_0000115 "A(n) smooth muscle cell that is part of a(n) taenia coli." ; terms:contributor ; a owl:Class ; rdfs:label "smooth muscle cell of taenia coli" ; rdfs:subClassOf obo:CL_1000279, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001278 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012419 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012419 ] ) ] . obo:CL_4033005 obo:IAO_0000115 "A(n) serous secreting cell that is part of a(n) bronchus submucosal gland." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The marker set PRR4, C6orf58 can identify the Human cell type serous secreting cell of bronchus submucosal gland in the lung with a confidence of 0.75 (NS-Forest FBeta value)." ; rdfs:label "serous secreting cell of bronchus submucosal gland" ; rdfs:subClassOf obo:CL_0000152, obo:CL_0019001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410043 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000054 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000313 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410043 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" . obo:CL_4033006 obo:IAO_0000115 "A(n) endothelial cell that is part of a(n) efferent lymphatic vessel." ; terms:contributor ; a owl:Class ; rdfs:label "endothelial cell of efferent lymphatic vessel" ; rdfs:subClassOf obo:CL_0002138, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010397 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010397 ] ) ] . obo:CL_4033007 obo:IAO_0000115 "A(n) brush cell that is part of a(n) epithelium of lobar bronchus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "brush cell of epithelium of lobar bronchus" ; rdfs:subClassOf obo:CL_0000082, obo:CL_0002208, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002339 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002339 ] ) ] . obo:CL_4033008 obo:IAO_0000115 "A(n) vein endothelial cell that is part of a(n) respiratory system." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "vein endothelial cell of respiratory system" ; rdfs:subClassOf obo:CL_0002543, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002543 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:CL_4033009 obo:IAO_0000115 "A(n) goblet cell that is part of a(n) epithelium of lobar bronchus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "goblet cell of epithelium of lobar bronchus" ; rdfs:subClassOf obo:CL_1000143, obo:CL_1000312, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002339 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002339 ] ) ] . obo:CL_4033010 obo:IAO_0000115 "A(n) neuroendocrine cell that is part of a(n) epithelium of lobar bronchus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "neuroendocrine cell of epithelium of lobar bronchus" ; rdfs:subClassOf obo:CL_0000082, obo:CL_0002328, obo:CL_0008055, obo:CL_1000223, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002339 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000165 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002339 ] ) ] . obo:CL_4033011 obo:IAO_0000115 "A(n) smooth muscle cell that is part of a(n) large intestine smooth muscle circular layer." ; terms:contributor ; a owl:Class ; rdfs:label "smooth muscle cell of large intestine smooth muscle circular layer" ; rdfs:subClassOf obo:CL_1000279, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001278 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012398 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012398 ] ) ] . obo:CL_4033012 obo:IAO_0000115 "A(n) smooth muscle cell that is part of a(n) large intestine smooth muscle longitudinal layer." ; terms:contributor ; a owl:Class ; rdfs:label "smooth muscle cell of large intestine smooth muscle longitudinal layer" ; rdfs:subClassOf obo:CL_1000279, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001278 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012399 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012399 ] ) ] . obo:CL_4033013 obo:IAO_0000115 "A keratinocyte of the epidermis suprabasal layer. This cell may express the differentiation markers keratin 10 and keratin 1." ; terms:contributor ; oboInOwl:creation_date "2023-02-02T11:17:04Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "suprabasal keratinocyte" ; rdfs:subClassOf obo:CL_4052061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010402 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000312 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010402 ] ) ] . obo:CL_4033014 obo:IAO_0000115 "A small, narrow, peg-shaped epithelial cell with little cytoplasm that is part of oviduct epithelium. This cell is rarer than the ciliated and secretory epithelial cells of the fallopian tube epithelium and is often found intercalated between them. Peg cells are generally distributed basally along the epithelium and have been found in high concentrations at the fimbriated, distal end of the fallopian tube in humans. It may have a regenerative/stem-cell function. In humans, markers include EPCAM, CD44, and ITGA6." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2023-02-02T15:07:12Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "FTE stem-like cell", "FTESC", "fallopian tube epithelial stem-like cell", "intercalary cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "In vitro evidence supports a stem-cell/regenerative function for these cells" ; rdfs:label "peg cell" ; rdfs:subClassOf obo:CL_4052019, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004804 ] . obo:CL_4033015 obo:IAO_0000115 "A star-shaped glial cell that is part of some retina. This cell links neurons to blood vessels and may provide structural and physiological support to optic nerve head axons." ; terms:contributor ; terms:date "2023-03-02T14:38:32Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "retinal astroglia" ; oboInOwl:inSubset cl:cellxgene_subset, cl:eye_upper_slim ; a owl:Class ; rdfs:comment "In response to elevated intraocular pressure, a retinal astrocyte may modulate extracellular matrix remodeling. In the human retina, a retinal astrocyte is GFAP-positive, SOD3-positive and GYPC-positive." ; rdfs:label "retinal astrocyte" ; rdfs:subClassOf obo:CL_0000127, obo:CL_0009004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000127 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] . obo:CL_4033016 obo:IAO_0000115 "A myofibroblast that is part of an alveoli during alveolarization. The contractile force of this cell elongates the secondary crest, while producing a framework of elastin and tenascin. During the maturation of the septa, secondary crest myofibroblasts, together with matrix fibroblasts, secrete metalloproteinases and other ECM‐remodeling proteins to thin the septal tip ECM. The secondary crest myofibroblast continues producing elastin, eventually undergoing apoptosis during adulthood." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-03-16T09:17:47Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "secondary-crest myofibroblast" ; oboInOwl:hasRelatedSynonym "SCMF", "SCMFs", "alveolar myofibroblast" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "secondary crest myofibroblast" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000186, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000114 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0048286 ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" . obo:CL_4033017 obo:IAO_0000115 "A smooth muscle cell that is part of a bronchiole." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-03-16T09:38:17Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "bronchiolar smooth muscle cell" ; rdfs:subClassOf obo:CL_0019019, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004515 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002186 ] ) ] . obo:CL_4033018 obo:IAO_0000115 "A megakaryocyte that is resident in the lung connective tissue." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-03-16T11:31:23Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "lung resident megakaryocyte", "lung-resident megakaryocyte" ; oboInOwl:hasRelatedSynonym "MKL", "lung MKs" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "lung megakaryocyte" ; rdfs:subClassOf obo:CL_0000556, obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000114 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000556 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000114 ] ) ] . obo:CL_4033019 obo:IAO_0000115 "An ON bipolar cell type with dendrites selectively contacting S-cones." ; terms:contributor ; terms:date "2023-04-04T09:48:15Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "BB cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "The axons of a blue cone bipolar cell terminate close to the ganglion cell layer, where they transfer the S-cone ON signal to small bistratified ganglion cells. Other targets of a blue cone bipolar cell include amacrine cells and possibly large bistratified ganglion cells." ; rdfs:label "ON-blue cone bipolar cell" ; rdfs:subClassOf obo:CL_0000749 . obo:CL_4033020 obo:IAO_0000115 "A mucus secreting cell that is part of a submucosal gland of the trachea." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-03-16T13:03:13Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "tracheal submucosal gland mucous cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mucus secreting cell of trachea gland" ; rdfs:subClassOf obo:CL_0000307, obo:CL_4033037, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005203 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000319 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005203 ] ) ] . obo:CL_4033021 obo:IAO_0000115 "A myoepithelial cell that is part of a submucosal gland of the trachea." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-03-16T13:36:43Z"^^xsd:dateTime ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "myoepithelial cell of trachea gland" ; rdfs:subClassOf obo:CL_0000185, obo:CL_0000307, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005203 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000185 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005203 ] ) ] . obo:CL_4033022 obo:IAO_0000115 "A mucus secreting cell of a submucosal gland of the bronchus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-03-16T15:12:52Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "bronchial gland mucous cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The marker set BPIFB2 can identify the Human cell type mucus secreting cell of bronchus submucosal gland in the lung with a confidence of 0.93 (NS-Forest FBeta value)." ; rdfs:label "mucus secreting cell of bronchus submucosal gland" ; rdfs:subClassOf obo:CL_0002328, obo:CL_4033037, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410043 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000053 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000319 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410043 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" . obo:CL_4033023 obo:IAO_0000115 "An epithelial cell that is part of a collecting duct of an airway submucosal gland." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-03-16T15:20:28Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The marker set GLYATL2, DMBT1 can identify the Human cell type airway submucosal gland collecting duct epithelial cell in the lung with a confidence of 0.46 (NS-Forest FBeta value)." ; rdfs:label "airway submucosal gland collecting duct epithelial cell" ; rdfs:subClassOf obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410077 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000052 ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" . obo:CL_4033024 obo:IAO_0000115 "A basal cell that is part of a duct of an airway submucosal gland." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , "https://orcid.org/0000-0002-9185-3994" ; terms:date "2023-03-16T15:51:39Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "airway submucosal gland duct basal cell" ; rdfs:subClassOf obo:CL_0000646, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410077 ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" . obo:CL_4033025 obo:IAO_0000115 "A fibroblast that is part of the fibrous layer of the perichondrium. This cell is responsible for collagen fiber production." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-03-16T16:12:50Z"^^xsd:dateTime ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "perichondrial fibroblast" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008305 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008305 ] ) ] . obo:CL_4033026 obo:IAO_0000115 "A perichondrial fibroblast that is part of the lung." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-03-16T16:15:39Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "PC-fibro" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "lung perichondrial fibroblast" ; rdfs:subClassOf obo:CL_0002553, obo:CL_4033025 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4033025 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:CL_4033027 obo:IAO_0000115 "An OFF diffuse bipolar cell that makes synaptic contact with both L/M and S-cone photoreceptors and only minimal contact with rod photoreceptors." ; terms:contributor ; terms:date "2023-04-04T10:48:29Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Diffuse Bipolar Cell Type DB1" ; oboInOwl:hasRelatedSynonym "DB1 bipolar", "DB1 bipolar cell", "DB1 cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "In primates, a diffuse bipolar 1 cell on average makes 81 ribbon (output) synapses, 13 contacts are with OFF parasol cells and 47 contacts are with OFF midget cells. This cell might make flat contacts at both triad-associated and non-triad-associated positions on the cone pedicle." ; rdfs:label "diffuse bipolar 1 cell" ; rdfs:subClassOf obo:CL_0000750 . obo:CL_4033028 obo:IAO_0000115 "An OFF diffuse bipolar cell that predominantly connects to ON parasol cells and lateral amacrine cells. This cell contains a large number of synaptic ribbons and a small axon arbor area." ; terms:contributor ; terms:date "2023-04-04T10:49:07Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "DB2 cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "In primates, a diffuse bipolar 2 cell makes an average of 133 ribbon synapses, 47 contacts are with OFF parasol cells and 4 contacts are with OFF midget cells." ; rdfs:label "diffuse bipolar 2 cell" ; rdfs:subClassOf obo:CL_0000750 . obo:CL_4033029 obo:IAO_0000115 "An OFF calbindin-positive bipolar cell that has a large dendritic field and stratifies narrowly close to the middle of the inner plexiform layer. Its axon terminal is characterized by regularly branching and varicose processes resembling beads on a string. Most of DB3a contacts with cones are triad-associated." ; terms:contributor ; terms:date "2023-04-04T10:53:33Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "DB3 cell", "DB3a cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Originally, DB3a cells were termed diffuse bipolar 3 (DB3) cells. When an additional bipolar type which stratifies slightly more vitread and is calbindin negative was detected, this cell was renamed diffuse bipolar 3a cell. The axons of neighboring DB3a cells make homologous gap junctions. The DB3a cells provide the majority of their output to OFF parasol cells." ; rdfs:label "diffuse bipolar 3a cell" ; rdfs:subClassOf obo:CL_0000750 . obo:CL_4033030 obo:IAO_0000115 "An OFF calbindin-negative bipolar cell that has a large dendritic field and stratifies narrowly close to the middle of the inner plexiform layer. Its axon terminal is characterized by regularly branching and varicose processes resembling beads on a string. Most of DB3b contacts with cones are non-triad-associated." ; terms:contributor ; terms:date "2023-04-04T10:53:42Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "DB3b cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "In humans, a DB3b cell is CD15 positive. A DB3b cell might make sparse contacts to rod photoreceptors." ; rdfs:label "diffuse bipolar 3b cell" ; rdfs:subClassOf obo:CL_0000750 . obo:CL_4033031 obo:IAO_0000115 "An ON diffuse bipolar cell that predominantly connects to ON parasol cells and lateral amacrine cells." ; terms:contributor ; terms:date "2023-04-04T09:51:10Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "DB4 cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "diffuse bipolar 4 cell" ; rdfs:subClassOf obo:CL_0000749 . obo:CL_4033032 obo:IAO_0000115 "An ON diffuse bipolar cell that has a large dendritic field and large axon terminals, which show little or no overlap. This cell predominantly connects to narrow thorny ganglion cells." ; terms:contributor ; terms:date "2023-04-04T09:51:22Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "DB6 cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "diffuse bipolar 6 cell" ; rdfs:subClassOf obo:CL_0000749 . obo:CL_4033033 obo:IAO_0000115 "An OFF bipolar cell with a small dendritic tree that provides most of the triad-associated basal (flat) contacts at cone pedicles." ; terms:contributor ; terms:date "2023-04-04T10:54:00Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "FMB cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "flat midget bipolar cell" ; rdfs:subClassOf obo:CL_0000750 . obo:CL_4033034 obo:IAO_0000115 "An ON bipolar cell with a small dendritic tree that forms most of the central (invaginating) elements opposite the synaptic ribbon at the cone triad." ; terms:contributor ; terms:date "2023-04-04T09:51:44Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "IMB cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "invaginating midget bipolar cell" ; rdfs:subClassOf obo:CL_0000749 . obo:CL_4033035 obo:IAO_0000115 "An ON bipolar cell that has large dendritic and axonal fields." ; terms:contributor ; terms:date "2023-04-04T09:54:15Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "GB cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "A giant bipolar cell is usually monostratified, although, very rarely, it can be bistratified." ; rdfs:label "giant bipolar cell" ; rdfs:subClassOf obo:CL_0000749 . obo:CL_4033036 obo:IAO_0000115 "An OFF bipolar cell that is fovea-specific and expresses FEZF1, NXPH1 and NXPH2." ; obo:RO_0002175 obo:NCBITaxon_9443 ; terms:contributor ; terms:date "2023-04-04T10:54:15Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "OFFx cell" ; rdfs:subClassOf obo:CL_0000750, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001786 ] . obo:CL_4033037 obo:IAO_0000115 "A mucus secreting cell of a submucosal gland of the tracheobronchial tree." ; terms:contributor ; terms:date "2023-04-20T10:55:50Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "mucus secreting cell of tracheobronchial tree submucosal gland" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000152, obo:CL_0000319, obo:CL_0002202, obo:CL_0008055, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410077 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000319 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007196 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410077 ] ) ] . obo:CL_4033038 obo:IAO_0000115 "An alpha-beta CD4 T cell that resides in the lung." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-04-27T10:15:45Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "lung resident memory CD4 T cell" ; oboInOwl:hasRelatedSynonym "lung CD4-positive TRM" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "lung resident memory CD4-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000897, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] . obo:CL_4033039 obo:IAO_0000115 "An alpha-beta CD8 T cell that resides in the lung." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-04-27T10:16:07Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "lung CD8-positive TRM" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "In the lung, CXCR6 regulates the localization of lung resident memory CD8-positive, alpha-beta T cells." ; rdfs:label "lung resident memory CD8-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000909, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] . obo:CL_4033040 obo:IAO_0000115 "A lung resident memory CD8-positive, alpha-beta T cell that is CD103-positive." ; terms:contributor , ; terms:date "2023-05-24T12:23:35Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "lung TRM CD8-positive, CD103-positive cell", "lung TRM CD8-positive, integrin alpha E-positive cell", "lung resident memory CD8-positive CD103-positive, alpha-beta T cell" ; a owl:Class ; rdfs:label "lung resident memory CD8-positive, CD103-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_4033039, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001010 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4033039 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001010 ] ) ] . obo:CL_4033041 obo:IAO_0000115 "An alveolar macrophage that expresses CCL3." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-06-15T12:53:08Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "alveolar macrophage CCL3-positive" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "The marker set TNIP3, CXCL5 can identify the Human cell type CCL3-positive alveolar macrophage in the lung with a confidence of 0.67 (NS-Forest FBeta value)." ; rdfs:label "CCL3-positive alveolar macrophage" ; rdfs:subClassOf obo:CL_0000583, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000002123 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000004 ] . obo:CL_4033042 obo:IAO_0000115 "An alveolar macrophage that expresses metallothionein." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-06-15T12:55:34Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "alveolar macrophage MT-positive", "alveolar macrophage metallothionein-positive" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The marker set HMOX1, HPGD can identify the Human cell type metallothionein-positive alveolar macrophage in the lung with a confidence of 0.41 (NS-Forest FBeta value)." ; rdfs:label "metallothionein-positive alveolar macrophage" ; rdfs:subClassOf obo:CL_0000583, [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000005 ] . obo:CL_4033043 obo:IAO_0000115 "A macrophage that is part of the lung connective tissue (pulmonary interstitium). This cell performs tissue remodeling and contributes to barrier immunity through antigen presentation." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-06-15T12:58:11Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "lung IM" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "The marker set F13A1, STAB1, FCGR2B can identify the Human cell type lung interstitial macrophage in the lung with a confidence of 0.46 (NS-Forest FBeta value)." ; rdfs:label "lung interstitial macrophage" ; rdfs:subClassOf obo:CL_0000864, obo:CL_0002320, obo:CL_1001603, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000114 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000031 ] . obo:CL_4033044 obo:IAO_0000115 "An epithelial cell part of respiratory tract epithelium that is a precursor of a multi-ciliated cell. This cell actively amplifies centrioles, a required step for multiciliogenesis." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-06-20T10:27:17Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "In humans, deuterosomal cells have been noted to have enriched expression of the following: PLK4, FOXJ1, DEUP1, FOXN4, YPEL1, HES6 and CDC20B. Deuterosomal cells were termed after deuterosomes, the platforms of active centriole amplification." ; rdfs:label "deuterosomal cell" ; rdfs:subClassOf obo:CL_0002368, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0098535 ] . obo:CL_4033045 obo:IAO_0000115 "A dendritic cell that captures antigens in a lung and migrates to a lymph node or to the spleen to activate T cells." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-06-21T10:04:46Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "lung mDC", "lung mDCs" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lung migratory dendritic cell" ; rdfs:subClassOf obo:CL_0000451 . obo:CL_4033046 obo:IAO_0000115 "A midget ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from invaginating midget bipolar cells." ; terms:contributor ; terms:date "2023-08-08T09:40:08Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "ON-midget RGC", "ON-midget cell", "inner stratifying midget cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "ON midget ganglion cell" ; rdfs:subClassOf obo:CL_4023032, obo:CL_4023188 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023032 obo:CL_4023188 ) ] . obo:CL_4033047 obo:IAO_0000115 "A midget ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from flat midget bipolar cells." ; terms:contributor ; terms:date "2023-08-08T11:05:37Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "OFF-midget RGC", "OFF-midget cell", "outer stratifying midget cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "OFF midget ganglion cell" ; rdfs:subClassOf obo:CL_4023033, obo:CL_4023188 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023033 obo:CL_4023188 ) ] . obo:CL_4033048 obo:IAO_0000115 "A respiratory epithelial cell derived from a basal cell, with a topographic nuclear position between the basal and luminal cells of the airway epithelium. This non-basal, intermediate progenitor cell has limited proliferative capacity and can differentiate into multiciliated, secretory, or rare airway cells (ionocytes, tuft cells, neuroendocrine cells). It shares some ultrastructural features with basal cells but lacks the defined characteristics of fully differentiated cellular phenotypes." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-06-20T10:44:30Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "respiratory parabasal cell", "respiratory suprabasal cell", "respiratory suprabasal progenitor cell" ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:comment "In humans, respiratory tract suprabasal cells have been noted to have enriched expression of the following: CK8, KRT13, IVL, and SERPINB3. Single-cell sequencing indicates that suprabasal cells derived from the nasal epithelium are distinct from those in the tracheobronchial epithelium.", "The marker set TNC, KRT15, SERPINB4 can identify the Human cell type respiratory tract suprabasal cell in the lung with a confidence of 0.62 (NS-Forest FBeta value)." ; rdfs:label "respiratory tract suprabasal cell" ; rdfs:subClassOf obo:CL_0002368, obo:CL_0011026, _:genid18447, [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000059 ] . obo:CL_4033049 obo:IAO_0000115 "A taste receptor cell that is part of a taste bud of a tongue." ; terms:contributor ; terms:date "2023-05-03T07:59:58Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "gustatory cell of tongue" ; a owl:Class ; rdfs:label "taste receptor cell of tongue" ; rdfs:subClassOf obo:CL_0000209, obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014451 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000209 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014451 ] ) ] . obo:CL_4033050 obo:IAO_0000115 "A neuron that releases catecholamine as a neurotransmitter." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2023-05-18T12:07:45Z"^^xsd:dateTime ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Frequently used when describing the developing nervous system in zebrafish. A catecholaminergic neuron expresses tyrosine hydroxylase (TH), tyrosine hydroxylase 2 (TH2), aromatic amino acid decarboxylase (AADC), dopamine b-hydroxylase (DBH), and phenylethanolamine-N-methyl transferase (PEMT), which are enzymes necessary for catecholamine synthesis." ; rdfs:label "catecholaminergic neuron" ; rdfs:subClassOf obo:CL_0000151, obo:CL_0000540, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0160043 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0160043 ] ) ] ; skos:prefLabel "catecholaminergic neuron" . obo:CL_4033051 obo:IAO_0000115 "A parasol ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB3a bipolar cells." ; terms:contributor ; terms:date "2023-08-08T12:34:57Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "OFF-parasol RGC", "OFF-parasol retinal ganglion cell", "outer parasol cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "OFF parasol ganglion cell" ; rdfs:subClassOf obo:CL_4023033, obo:CL_4023189 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023033 obo:CL_4023189 ) ] . obo:CL_4033052 obo:IAO_0000115 "A parasol ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB4 bipolar cells." ; terms:contributor ; terms:date "2023-08-08T12:39:35Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "ON-parasol RGC", "ON-parasol retinal ganglion cell", "inner parasol cell" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "ON parasol ganglion cell" ; rdfs:subClassOf obo:CL_4023032, obo:CL_4023189 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4023032 obo:CL_4023189 ) ] . obo:CL_4033053 obo:IAO_0000115 "A bistratfied retinal ganglion cell with a small dendritic field that has dendrites in the ON and OFF sublamina of the retinal inner plexiform layer and carries blue-ON/yellow-OFF signals. This cell receives bipolar and amacrine input to both the OFF and ON dendritic tree." ; terms:contributor ; terms:date "2023-08-08T12:43:56Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "small bistratified cell", "small bistratified cell, blue-ON/yellow-OFF ganglion cell" ; oboInOwl:hasRelatedSynonym "Polyak's shrub cell", "SBS ganglion cell", "sbRGC" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "small bistratified retinal ganglion cell" ; rdfs:subClassOf obo:CL_0003001, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001792 ] . obo:CL_4033054 obo:IAO_0000115 "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics." ; terms:contributor ; terms:date "2023-08-22T13:40:28Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "perivascular cell" ; rdfs:subClassOf obo:CL_0000000, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002049 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002049 ] ) ] . obo:CL_4033055 obo:IAO_0000115 "A multi-ciliated epithelial cell located in ciliated duct of an airway submucosal gland, characterized by a columnar shape and motile cilia on its apical surface." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2023-09-08T10:32:27Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "airway submucosal gland duct ciliated cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "airway submucosal gland duct multiciliated cell" ; rdfs:subClassOf obo:CL_0000068, obo:CL_0005012, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410077 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8600014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410077 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8600014 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0031514 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0010007 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" . obo:CL_4033056 obo:IAO_0000115 "A terminally differentiated, specialized keratinocyte originating primarily from the nail matrix. During onychokeratinization, these cells undergo progressive flattening and produce high levels of hard, disulfide cross-linked keratins (Eckhart et al., 2024) that form the rigid, compact nail plate. Unlike epidermal keratinocytes, onychocytes are firmly integrated into the nail plate and do not desquamate." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2023-10-03T12:49:46Z"^^xsd:dateTime ; oboInOwl:inSubset cl:cellxgene_subset, core:human_reference_atlas ; a owl:Class ; rdfs:label "onychocyte" ; rdfs:subClassOf obo:CL_4052061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008198 ] . obo:CL_4033057 obo:IAO_0000115 "A luminal epithelial cell of the mammary gland that can proliferate and has the potential to differentiate into a lactocyte during pregnancy. In humans, a luminal adaptive secretory precursor cell can be identified by high levels of the markers EpCAM and CD49f, and in mice it can be identified by low levels of CD29 and high levels of CD14, Kit, CD61, and Tspan8." ; terms:contributor , ; terms:date "2023-10-13T13:02:55Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "alveolar cell", "alveolar progenitor", "luminal progenitor", "luminal progenitor cell", "luminal secretory cell" ; oboInOwl:hasExactSynonym "ER-negative luminal alveolar progenitor" ; oboInOwl:hasRelatedSynonym "AP", "AV", "LASP", "LP", "LumSec" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "luminal adaptive secretory precursor cell of mammary gland" ; rdfs:subClassOf obo:CL_0002326, obo:CL_0011026 . obo:CL_4033058 obo:IAO_0000115 "A luminal epithelial cell of the mammary gland that transduces endocrine cues to orchestrate proliferation, architectural remodeling, and differentiation of other cells in the mammary gland via paracrine signaling. This cell expresses high levels of estrogen receptors. In humans, a luminal hormone-sensing cell can be identified by high levels of EpCAM and low levels of CD49f, and in mice it can be identified by low levels of CD29 and high levels of Foxa1, CD133, and Sca1 (Ly6a)." ; terms:contributor , ; terms:date "2023-10-16T08:30:25Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "hormone sensing cell", "hormone-sensing mammary epithelial cell", "luminal hormone-responsive cell", "luminal mature cell" ; oboInOwl:hasExactSynonym "ER-positive luminal hormone-sensor cell" ; oboInOwl:hasRelatedSynonym "HS", "HS-MEC", "LHS", "LumHR" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:comment "Following lineage specification, a luminal hormone-sensing cell expresses receptors for one or more hormones, such as estrogens, progesterone, androgens, and prolactin. In response to progesterone, luminal hormone-sensing cells express TNFSF11, WNT4, and RSPO1, among other factors, which cause branching, proliferation, and partial differentiation in LASP and B-Myo cells during luteal phases of the estrous/menstrual cycle and during gestation. During ductal elongation, ER activity drives expression of AREG in LHS cells, which is necessary for proliferation of the epithelium to fill the mammary fat pad." ; rdfs:label "luminal hormone-sensing cell of mammary gland" ; rdfs:subClassOf obo:CL_0002326, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000007204 ] . obo:CL_4033059 obo:IAO_0000115 "A lactocyte that highly expresses genes associated with transcription, immune cell function, and cellular stress. A lactocyte type 1 also expresses genes involved in milk component biosynthesis (e.g., LALBA and CSNs), albeit at lower levels than a lactocyte type 2." ; terms:contributor , ; terms:date "2023-10-16T13:15:36Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "luminal cluster 1 cell" ; oboInOwl:hasRelatedSynonym "LC1", "LMC major luminal cluster 1", "progenitor MEC" ; a owl:Class ; rdfs:label "lactocyte type 1" ; rdfs:subClassOf obo:CL_0002325 . obo:CL_4033060 obo:IAO_0000115 "A lactocyte that highly expresses genes associated with lipid production and milk component biosynthesis." ; terms:contributor , ; terms:date "2023-10-16T13:15:55Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "luminal cluster 2 cell" ; oboInOwl:hasRelatedSynonym "LC2", "LMC major luminal cluster 2" ; a owl:Class ; rdfs:label "lactocyte type 2" ; rdfs:subClassOf obo:CL_0002325 . obo:CL_4033061 obo:IAO_0000115 "An endothelial cell that is part of a central vein of liver." ; terms:contributor ; oboInOwl:hasBroadSynonym "endothelial cell of central vein" ; a owl:Class ; rdfs:label "endothelial cell of central vein of liver" ; rdfs:subClassOf obo:CL_0002543, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006841 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006841 ] ) ] . obo:CL_4033062 obo:IAO_0000115 "A trophoblast cell that invades the uterine wall to anchor the placenta to the uterus. An interstitial extravillous trophoblast cell differentiates from an extravillous trophoblast cell, becoming hyperchromatic and changing its morphology to a fibroblast-like spindle-shaped cell. In humans, this cell can be distinguished by the expression of placental-specific protein 8, which stimulates migration." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2024-01-08T15:43:15Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "invasive interstitial extravillous trophoblast cell" ; oboInOwl:hasRelatedSynonym "iEVT", "interstitial extravillous trophoblast", "interstitial trophoblast" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "interstitial extravillous trophoblast cell" ; rdfs:subClassOf obo:CL_0000351, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0008036 ] . obo:CL_4033063 obo:IAO_0000115 "A trophoblast cell that invades the maternal spiral arteries and replace the endothelial lining, remodeling the vessels and allowing for adequate blood transport into the placenta. An endovascular extravillous trophoblast cell differentiates from an extravillous trophoblast cell. In humans, this cell can be distinguished by the expression of CD56." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2024-01-08T15:43:32Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "eEVT", "endovascular extravillous trophoblast", "endovascular trophoblast" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Shortly after implantation, the endovascular extravillous trophoblast cells occlude the maternal spiral arteries, preventing premature oxygen delivery to the placental villi and reducing fetal oxidative stress." ; rdfs:label "endovascular extravillous trophoblast cell" ; rdfs:subClassOf obo:CL_0000351, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0008036 ] . obo:CL_4033064 obo:IAO_0000115 "A tissue-resident macrophage that is part of the uterus." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2024-01-08T16:05:09Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "uterine macrophage" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Uterine macrophages are reported to be evenly distributed throughout the endometrial stroma but with aggregations observed close to the lumen of superficial secretory glands." ; rdfs:label "uterine resident macrophage" ; rdfs:subClassOf obo:CL_0000864, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000864 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ) ] . obo:CL_4033065 obo:IAO_0000115 "A mature B cell that serves as an intermediate stage in the differentiation of naive B cells into a plasmablast. A preplasmablast expresses CD30 and IL-6R and lacks expression of CD20, CD23, CD38 and CD138." ; terms:contributor , ; terms:date "2024-04-25T09:14:58Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "pre-plasmablast", "preplasmablastic cell" ; oboInOwl:hasRelatedSynonym "prePB" ; a owl:Class ; rdfs:label "preplasmablast" ; rdfs:subClassOf obo:CL_0000785, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000788 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000980 ] . obo:CL_4033066 obo:IAO_0000115 "A supporting cell that is part of the ovary and differentiates into a granulosa cell. A pre-granulosa cell develops from an early supporting gonadal cell by repressing testis determination, which can then proliferate to form primordial follicles." ; terms:contributor , ; terms:date "2024-06-07T12:04:57Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "ovarian pregranulosa cell", "pregranulosa cell" ; oboInOwl:hasRelatedSynonym "PG cell" ; a owl:Class ; rdfs:label "pre-granulosa cell" ; rdfs:subClassOf obo:CL_0000255, obo:CL_0000630, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002210 ; owl:someValuesFrom obo:CL_4033083 ] . obo:CL_4033067 obo:IAO_0000115 "A follicular cell of ovary that differentiates from a cuboidal granulosa cell during the secondary follicle stage. Mural granulosa cells line the inner surface of the follicle wall, surrounding the fluid-filled antral cavity. These cells produce oestrogen during the follicular phase in response to follicle-stimulating hormone (FSH), and progesterone after ovulation in response to luteinizing hormone (LH)." ; terms:contributor , ; terms:date "2024-06-07T12:15:13Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0005289" ; oboInOwl:hasRelatedSynonym "MGC", "mural GC" ; a owl:Class ; rdfs:label "mural granulosa cell" ; rdfs:subClassOf obo:CL_0000501, obo:UBERON_0004120, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_4033084 ] . obo:CL_4033068 obo:IAO_0000115 "A(n) B cell that is cycling." ; oboInOwl:hasExactSynonym "proliferating B cell" ; a owl:Class ; rdfs:label "cycling B cell" ; rdfs:subClassOf obo:CL_0000236, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000236 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4033069 obo:IAO_0000115 "A(n) T cell that is cycling." ; oboInOwl:hasExactSynonym "proliferating T cell" ; a owl:Class ; rdfs:label "cycling T cell" ; rdfs:subClassOf obo:CL_0000084, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4033070 obo:IAO_0000115 "A(n) dendritic cell that is cycling." ; oboInOwl:hasExactSynonym "proliferating dendritic cell" ; a owl:Class ; rdfs:label "cycling dendritic cell" ; rdfs:subClassOf obo:CL_0000451, obo:CL_4033078 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000451 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4033071 obo:IAO_0000115 "A(n) natural killer cell that is cycling." ; oboInOwl:hasExactSynonym "proliferating natural killer cell" ; a owl:Class ; rdfs:label "cycling natural killer cell" ; rdfs:subClassOf obo:CL_0000623, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000623 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4033072 obo:IAO_0000115 "A(n) gamma-delta T cell that is cycling." ; oboInOwl:hasExactSynonym "proliferating gamma-delta T cell" ; a owl:Class ; rdfs:label "cycling gamma-delta T cell" ; rdfs:subClassOf obo:CL_0000798, obo:CL_4033069 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000798 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4033073 obo:IAO_0000115 "A(n) monocyte that is cycling." ; oboInOwl:hasExactSynonym "proliferating monocyte" ; a owl:Class ; rdfs:label "cycling monocyte" ; rdfs:subClassOf obo:CL_0000576, obo:CL_4033078, obo:CL_4033081 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000576 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4033074 obo:IAO_0000115 "A(n) CD8-positive, alpha-beta T cell that is cycling." ; oboInOwl:hasExactSynonym "proliferating CD8-positive, alpha-beta T cell" ; a owl:Class ; rdfs:label "cycling CD8-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000625, obo:CL_4033069 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000625 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4033075 obo:IAO_0000115 "A(n) CD4-positive, alpha-beta T cell that is cycling." ; oboInOwl:hasExactSynonym "proliferating CD4-positive, alpha-beta T cell" ; a owl:Class ; rdfs:label "cycling CD4-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000624, obo:CL_4033069 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4033076 obo:IAO_0000115 "A(n) macrophage that is cycling." ; oboInOwl:hasExactSynonym "proliferating macrophage" ; a owl:Class ; rdfs:label "cycling macrophage" ; rdfs:subClassOf obo:CL_0000235, obo:CL_4033078, obo:CL_4033081 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000235 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4033077 obo:IAO_0000115 "A(n) alveolar macrophage that is cycling." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "proliferating alveolar macrophage" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "The marker set PCLAF, RRM2, UBE2C, NUSAP1 can identify the Human cell type cycling alveolar macrophage in the lung with a confidence of 0.26 (NS-Forest FBeta value)." ; rdfs:label "cycling alveolar macrophage" ; rdfs:subClassOf obo:CL_0000583, obo:CL_4033076, [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000006 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000583 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4033078 obo:IAO_0000115 "A(n) mononuclear phagocyte that is cycling." ; oboInOwl:hasExactSynonym "proliferating mononuclear phagocyte" ; a owl:Class ; rdfs:label "cycling mononuclear phagocyte" ; rdfs:subClassOf obo:CL_0000113, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000113 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4033079 obo:IAO_0000115 "A(n) endothelial cell of lymphatic vessel that is cycling." ; oboInOwl:hasExactSynonym "proliferating endothelial cell of lymphatic vessel" ; a owl:Class ; rdfs:label "cycling endothelial cell of lymphatic vessel" ; rdfs:subClassOf obo:CL_0002138, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002138 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4033080 obo:IAO_0000115 "A(n) pulmonary alveolar type 2 cell that is cycling." ; obo:RO_0002175 obo:NCBITaxon_9606 ; oboInOwl:hasExactSynonym "proliferating pulmonary alveolar type 2 cell" ; a owl:Class ; rdfs:comment "The marker set PEG10, PRC1, TOP2A can identify the Human cell type cycling pulmonary alveolar type 2 cell in the lung with a confidence of 0.61 (NS-Forest FBeta value)." ; rdfs:label "cycling pulmonary alveolar type 2 cell" ; rdfs:subClassOf obo:CL_0002063, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000010 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002063 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4033081 obo:IAO_0000115 "A(n) myeloid cell that is cycling." ; oboInOwl:hasExactSynonym "proliferating myeloid cell" ; a owl:Class ; rdfs:label "cycling myeloid cell" ; rdfs:subClassOf obo:CL_0000763, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000763 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4033082 obo:IAO_0000115 "A(n) basal cell that is cycling." ; oboInOwl:hasExactSynonym "proliferating basal cell" ; a owl:Class ; rdfs:label "cycling basal cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000646, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000646 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4033083 obo:IAO_0000115 "A granulosa cell that has a squamous morphology and form a single layer around the oocyte in primordial follicles. This cell develops directly into a cuboidal granulosa cell during the primordial-to-primary follicle transition." ; terms:contributor ; terms:date "2024-09-24T13:13:24Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "flattened granulosa cell" ; oboInOwl:hasRelatedSynonym "pre-granulosa cell", "squamous GC" ; a owl:Class ; rdfs:comment "Often in literature squamous granulosa cell and pre-granulosa cell are used as synonyms. However, this term only makes reference to the quiescent granulosa cells that surround the primordial ovarian follicle, while a pre-granulosa cell proliferates to form the primordial follicle (and thus cells become the squamous granulosa cells)." ; rdfs:label "squamous granulosa cell" ; rdfs:subClassOf obo:CL_0000501, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003981 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002207 ; owl:someValuesFrom obo:CL_4033066 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002210 ; owl:someValuesFrom obo:CL_4033084 ] . obo:CL_4033084 obo:IAO_0000115 "A granulosa cell that has a cuboidal morphology and develops from squamous granulosa cell during the transition between primordial follicle to primary follicle. Cuboidal granulosa cells proliferate to form a second layer within secondary follicles." ; terms:contributor ; terms:date "2024-09-24T13:14:57Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "columnar granulosa cell", "cuboidal epithelial granulosa cell" ; oboInOwl:hasRelatedSynonym "columnar GC", "cuboidal GC" ; a owl:Class ; rdfs:label "cuboidal granulosa cell" ; rdfs:subClassOf obo:CL_0000501, obo:UBERON_0004120, [ a owl:Restriction ; owl:onProperty obo:RO_0002207 ; owl:someValuesFrom obo:CL_4033083 ] . obo:CL_4033085 obo:IAO_0000115 "An ON diffuse bipolar cell that stratifies in the stratum 3 of the inner plexiform layer to make synapses with ON parasol ganglion cells. A diffuse bipolar 5 cell has high expression of MYO16 compared with other bipolar cells." ; obo:RO_0002175 obo:NCBITaxon_9443 ; terms:contributor ; terms:date "2024-10-16T12:46:53Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "DB5 cell" ; a owl:Class ; rdfs:comment "A diffuse bipolar 5 cell typically contacts 7–8 cone photoreceptors. The number and thickness of its dendritic processes are intermediate between those of a diffuse bipolar 6 cell (less dense and thinner) and a diffuse bipolar 4 cell (denser and thicker)." ; rdfs:label "diffuse bipolar 5 cell" ; rdfs:subClassOf obo:CL_0000749 . obo:CL_4033086 obo:IAO_0000115 "A tissue-resident macrophage that is associated with lipids. This cell responsible of anti-inflammatory functions, lipid accumulation and enhancing phagocytosis (Wculek et al., 2022, Liu et al., 2022). In mice and humans, a lipid-associated macrophage is characterized by the marker Trem2 (Jaitlin et al., 2019)." ; terms:contributor , ; terms:date "2024-10-17T10:20:13Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "LAM" ; a owl:Class ; rdfs:comment "Distinct from “adipose macrophage” in Trem2 expression, and is not limited to adipose tissue. Guilliams et al. describe these cells as being distinct from Kupffer cells." ; rdfs:label "lipid-associated macrophage" ; rdfs:subClassOf obo:CL_4047053 . obo:CL_4033087 obo:IAO_0000115 "A tissue-resident macrophage that is part of the placenta. This cell helps preventing immunological rejection of the fetus by modulating the immune environment. A placental resident macrophage has high plasticity to adapt to the changing needs of each phase of pregnancy." ; terms:contributor , ; terms:date "2024-10-31T10:24:21Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "placental macrophage" ; a owl:Class ; rdfs:label "placental resident macrophage" ; rdfs:subClassOf obo:CL_0000864, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000864 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:CL_4033088 obo:IAO_0000115 "A resident macrophage that is part of the decidua. Some decidual macrophages are derived from maternal blood monocytes that are recruited to the uterus shortly after conception. The main functions of a decidual macrophage are implantation, placental development, immune regulation and vascular remodeling." ; terms:contributor , ; terms:date "2024-10-31T10:33:04Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "decidual macrophage", "maternal decidual macrophage" ; a owl:Class ; rdfs:label "decidual resident macrophage" ; rdfs:subClassOf obo:CL_0000349, obo:CL_4033087, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002450 ] . obo:CL_4033089 obo:IAO_0000115 "A follicular cell of ovary that has begun to degenerate and undergo atresia, a specialized apoptosis. This cell is found in an atretic follicle, which is an ovarian follicle that started to mature but failed to reach full development and instead regresses." ; terms:contributor ; terms:date "2024-11-05T11:23:25Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "atretic follicular cell of ovary" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0002174, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0001552 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002174 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0001552 ] ) ] . obo:CL_4033090 obo:IAO_0000115 "A granulosa cell that is undergoing atresia. This cell type displays distinct morphological alterations compared with a healthy granulosa cell, including pyknosis (nuclear condensation) and cellular shrinkage." ; terms:contributor ; terms:date "2024-11-05T11:25:28Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "apoptotic granulosa cell" ; a owl:Class ; rdfs:label "atretic granulosa cell" ; rdfs:subClassOf obo:CL_4033089, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000501 ] . obo:CL_4033091 obo:IAO_0000115 "An amacrine cell that uses both GABA and glycine as neurotransmitters." ; terms:contributor ; terms:date "2024-12-02T13:44:17Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "glycinergic/GABAergic amacrine neuron" ; a owl:Class ; rdfs:label "glycinergic-GABAergic amacrine cell" ; rdfs:subClassOf obo:CL_0008059, obo:CL_4030027, obo:CL_4030028 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000561 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061537 ] ) ] . obo:CL_4033092 obo:IAO_0000115 "An enterocyte that is part of a duodenal epithelium and expresses beta-1,3-glucuronyltransferase 1 (B3GAT1), also known as CD57 or HNK-1." ; terms:contributor , , ; terms:date "2024-12-06T14:32:49Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "CD57+ enterocyte" ; a owl:Class ; rdfs:comment "While CD57 is traditionally associated with immune cells (e.g., NK cells), its expression on enterocytes marks unique epithelial subsets with specific functions or maturation states. These cells are specially enriched in areas of the duodenum within submucosal glands." ; rdfs:label "CD57-positive enterocyte" ; rdfs:subClassOf obo:CL_1000335, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008346 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001440 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000584 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008346 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001440 ] ) ] . obo:CL_4033093 obo:IAO_0000115 "A stem cell that is part of the corneo-scleral limbus. This cell type resides at the basal layer of the epithelium and has a small size and high nuclear to cytoplasmatic ratio (Secker and Daniels, 2009). A limbal stem cell is responsible for corneal epithelial renewal and repair (Li et al., 2023), and to help maintain a clear corneal surface by preventing conjunctival epithelial cells from migrating onto the cornea (Wang et al., 2023)." ; terms:contributor , ; terms:date "2024-12-11T13:59:19Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "limbal epithelial stem cell", "limbal stem cell" ; oboInOwl:hasRelatedSynonym "LESC", "LSC" ; a owl:Class ; rdfs:label "limbal epithelial stem cell of cornea" ; rdfs:subClassOf obo:CL_0000036, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000482 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006761 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000575 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000034 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006761 ] ) ] . obo:CL_4033094 obo:IAO_0000115 "A transcriptionally distinct memory B cell whose presence increases with age, during infections, and in autoimmune diseases. In humans and mice, this cell type can be identified by the expression of T-bet, CD11c, CD11b, and the lack of CD21. An age-associated B cell responds to TLR stimuli, may produce autoantibodies, and participates in antiviral responses and pathogen clearance." ; terms:contributor , ; terms:date "2025-01-08T14:44:57Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "ABC" ; a owl:Class ; rdfs:label "age-associated B cell" ; rdfs:subClassOf obo:CL_0000787 . obo:CL_4033095 obo:IAO_0000115 "An ON bipolar cell that has high expression of DIRC3, KCNJ3, LINC01915, PTPRK compared with other bipolar cells." ; terms:contributor ; terms:date "2025-01-14T13:48:42Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "DB4a" ; a owl:Class ; rdfs:label "diffuse bipolar 4a cell" ; rdfs:subClassOf obo:CL_0000749, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] . obo:CL_4033096 obo:IAO_0000115 "An ON bipolar cell that has high expression of NOS1AP compared with other bipolar cells." ; terms:contributor ; terms:date "2025-01-14T13:49:08Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "DB4b" ; a owl:Class ; rdfs:label "diffuse bipolar 4b cell" ; rdfs:subClassOf obo:CL_0000749, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] . obo:CL_4033097 obo:IAO_0000115 "A specialised endothelial cell that is part of the canal of Schlemm. This cell type shares characteristics and expresses markers of both blood and lymphatic endothelial cells (Kizhatil et al., 2014) and regulates aqueous humor outflow resistance by modulating pore formation and responding to mechanical strain (Stamer et al., 2016)." ; terms:contributor ; terms:date "2025-06-16T13:55:29Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "SC endothelial cell", "SEC" ; a owl:Class ; rdfs:label "Schlemm's canal endothelial cell" ; rdfs:subClassOf obo:CL_0002543, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004029 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004029 ] ) ] ; foaf:depiction "http://purl.obolibrary.org/obo/cl/images/Schlemms_canal_endo_cell_PMID26402712.png"^^xsd:anyURI . obo:CL_4033098 obo:IAO_0000115 "A Schlemm's canal endothelial cell that lines the inner wall of the Schlemm's canal. This cell exhibits a cobblestone appearance due to the significant biomechanical load it experiences, as well as the segmental flow of aqueous humor. The degree of biomechanical stress can lead to the formation of dome-like outpouchings known as giant vacuoles. In addition, the cell contains transcellular pores that mediate aqueous humor transport (Dautriche et al., 2015). This endothelial cell also displays prominent peripheral F-actin bands which help maintain structural integrity under pressure (Ethier et al., 2004)." ; terms:contributor ; terms:date "2025-06-17T13:33:32Z"^^xsd:dateTime ; oboInOwl:hasNarrowSynonym "human Schlemm's canal inner wall cell" ; oboInOwl:hasRelatedSynonym "HSCIW cell" ; a owl:Class ; rdfs:label "inner wall Schlemm's canal endothelial cell" ; rdfs:subClassOf obo:CL_4033097, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0046930 ] ; foaf:depiction "http://purl.obolibrary.org/obo/cl/images/Schlemms_canal_endo_cell_PMID26402712.png"^^xsd:anyURI . obo:CL_4033099 obo:IAO_0000115 "A Schlemm's canal endothelial cell that lines the outer wall of the Schlemm's canal. This cell displays a smooth and flat morphology (Dautriche et al., 2015) and it is distinguished by the presence of Weibel-Palade bodies, specialized organelles that produce, store, and release P-Selectin (Hamanaka et al., 1992). This endothelial cell also exhibits stellate (star-shaped) actin arrangements distributed throughout much of the cell (Ethier et al., 2004)." ; terms:contributor ; terms:date "2025-06-17T13:33:41Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "outer wall Schlemm's canal endothelial cell" ; rdfs:subClassOf obo:CL_4033097, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0033093 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001432 ] ; foaf:depiction "http://purl.obolibrary.org/obo/cl/images/Schlemms_canal_endo_cell_PMID26402712.png"^^xsd:anyURI . obo:CL_4033100 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the atrial intrinsic cardiac ganglion and expresses the marker tyrosine hydroxylase (TH)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "atrial intrinsic cardiac ganglion TH neuron" ; rdfs:subClassOf obo:CL_0010022, obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8600120 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033101 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "superior cervical ganglion TH/DBH neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001989 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000006294 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033102 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker tyrosine hydroxylase (TH)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "superior cervical ganglion TH neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001989 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033103 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker neuropeptide Y (NPY)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "superior cervical ganglion NPY neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001989 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011387 ] . obo:CL_4033104 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "superior cervical ganglion TH/NPY neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001989 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011387 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033105 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker somatostatin (SST)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "superior cervical ganglion SST neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001989 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000015665 ] . obo:CL_4033106 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker vasoactive intestinal peptide (VIP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "superior cervical ganglion VIP neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001989 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017299 ] . obo:CL_4033107 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker calcitonin gene-related peptide (CGRP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "superior cervical ganglion CGRP neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001989 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000027226 ] . obo:CL_4033108 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker dopamine beta-hydroxylase (DBH)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "middle cervical ganglion DBH neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001990 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000006294 ] . obo:CL_4033109 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker tyrosine hydroxylase (TH)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "middle cervical ganglion TH neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001990 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033110 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "middle cervical ganglion TH/NPY neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001990 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011387 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033111 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker neuropeptide Y (NPY)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "middle cervical ganglion NPY neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001990 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011387 ] . obo:CL_4033112 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker vasoactive intestinal peptide (VIP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "middle cervical ganglion VIP neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001990 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017299 ] . obo:CL_4033113 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker enkephalin." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "cervicothoracic ganglion enkephalin neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002441 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000020924 ] . obo:CL_4033114 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker tyrosine hydroxylase (TH)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "cervicothoracic ganglion TH neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002441 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033115 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "cervicothoracic ganglion TH/NPY neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002441 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011387 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033116 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker vasoactive intestinal peptide (VIP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "cervicothoracic ganglion VIP neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002441 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017299 ] . obo:CL_4033117 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker vesicular acetylcholine transporter (VAChT)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "cervicothoracic ganglion VAChT neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002441 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000014968 ] . obo:CL_4033118 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the thoracic ganglion and expresses the marker enkephalin." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "thoracic ganglion enkephalin neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000961 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000020924 ] . obo:CL_4033119 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the thoracic ganglion and expresses the marker tyrosine hydroxylase (TH)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "thoracic ganglion TH neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000961 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033120 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the thoracic ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "thoracic ganglion TH/NPY neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000961 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011387 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033121 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker vasoactive intestinal peptide (VIP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "lumbar ganglion VIP neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8600121 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000005404 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017299 ] . obo:CL_4033122 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker somatostatin (SST) and tyrosine hydroxylase (TH)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "lumbar ganglion SST/TH neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8600121 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000015665 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033123 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "lumbar ganglion TH/NPY neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8600121 ], _:genid18900, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033124 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker tyrosine hydroxylase (TH)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "lumbar ganglion TH neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8600121 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033125 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker neuropeptide Y (NPY)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "lumbar ganglion NPY neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8600121 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011387 ] . obo:CL_4033126 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the sacral ganglion and expresses the marker tyrosine hydroxylase (TH)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "sacral ganglion TH neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8600122 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033127 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the lower airway ganglion and expresses the marker choline O-acetyltransferase (ChAT) and vasoactive intestinal peptide (VIP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "lower airway ganglion ChAT/VIP neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8600123 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000005404 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017299 ] . obo:CL_4033128 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker vasoactive intestinal peptide (VIP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "celiac ganglion VIP neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002262 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017299 ] . obo:CL_4033129 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker peptide histidine isoleucine (PHI)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "celiac ganglion PHI neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002262 ] . obo:CL_4033130 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker calcitonin gene-related peptide (CGRP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "celiac ganglion CGRP neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002262 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000027226 ] . obo:CL_4033131 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker substance P (SP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "celiac ganglion SP neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002262 ] . obo:CL_4033132 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker somatostatin (SOM)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "celiac ganglion SOM neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002262 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000015665 ] . obo:CL_4033133 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker somatostatin (SOM) and calcitonin gene-related peptide (CGRP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "celiac ganglion SOM/CGRP neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002262 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000004973 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000015665 ] . obo:CL_4033134 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the superior mesenteric ganglion and expresses the marker substance P (SP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "superior mesenteric ganglion SP neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005479 ] . obo:CL_4033135 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the inferior mesenteric ganglion and expresses the marker tyrosine hydroxylase (TH)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "inferior mesenteric ganglion TH neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005453 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033136 obo:IAO_0000115 "A sympathetic neuron that has the soma located in the inferior mesenteric ganglion and expresses the marker substance P (SP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "inferior mesenteric ganglion SP neuron" ; rdfs:subClassOf obo:CL_0011103, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005453 ] . obo:CL_4033137 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the otic ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "otic ganglion nNOS neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0003963 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011326 ] . obo:CL_4033138 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the otic ganglion and expresses the marker vasoactive intestinal peptide (VIP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "otic ganglion VIP neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0003963 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017299 ] . obo:CL_4033139 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the ciliary ganglion and expresses the marker vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "ciliary ganglion VIP/PHI neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002058 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017299 ] . obo:CL_4033140 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the ciliary ganglion and expresses the marker tyrosine hydroxylase (TH)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "ciliary ganglion TH neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002058 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033141 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the submandibular ganglion and expresses the marker tyrosine hydroxylase (TH)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "submandibular ganglion TH cholinergic neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002059 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033142 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the submandibular ganglion and expresses the marker vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "submandibular ganglion VIP/PHI neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002059 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017299 ] . obo:CL_4033143 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the submandibular ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "submandibular ganglion nNOS neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002059 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011326 ] . obo:CL_4033144 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pterygopalatine ganglion and expresses the marker vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "pterygopalatine ganglion VIP/PHI neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0003962 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017299 ] . obo:CL_4033145 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pterygopalatine ganglion and expresses the marker vasoactive intestinal peptide (VIP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "pterygopalatine ganglion VIP neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0003962 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017299 ] . obo:CL_4033146 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pterygopalatine ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "pterygopalatine ganglion nNOS neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0003962 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011326 ] . obo:CL_4033147 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the vestibular ganglion and expresses the marker substance P (SP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "vestibular ganglion SP neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000032, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002824 ] . obo:CL_4033148 obo:IAO_0000115 "A sensory neuron that has the soma located in the nodose ganglion and expresses the marker transient receptor potential vanilloid 1 (TRPV1)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "nodose ganglion TRPV1 neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000101, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005363 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001065 ] . obo:CL_4033149 obo:IAO_0000115 "A sensory neuron that has the soma located in the nodose ganglion and expresses the marker purinergic receptor P2X3 (P2X3)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "nodose ganglion P2X3 neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000101, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005363 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000012190 ] . obo:CL_4033150 obo:IAO_0000115 "A sensory neuron that has the soma located in the nodose ganglion and expresses the marker transient receptor potential vanilloid 2 (TRPV2)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "nodose ganglion TRPV2 neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000101, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005363 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001064 ] . obo:CL_4033151 obo:IAO_0000115 "A sensory neuron that has the soma located in the nodose ganglion and expresses the marker parvalbumin (PVALB)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "nodose ganglion PVALB neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000101, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005363 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000013502 ] . obo:CL_4033152 obo:IAO_0000115 "A sensory neuron that has the soma located in the jugular ganglion and expresses the marker transient receptor potential vanilloid 1 (TRPV1)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "jugular ganglion TRPV1 neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000101, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005364 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001065 ] . obo:CL_4033153 obo:IAO_0000115 "A sensory neuron that has the soma located in the jugular ganglion and expresses the marker transient receptor potential vanilloid 2 (TRPV2)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "jugular ganglion TRPV2 neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000101, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005364 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001064 ] . obo:CL_4033154 obo:IAO_0000115 "A sensory neuron that has the soma located in the jugular ganglion and expresses the marker substance P (SP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "jugular ganglion SP neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000101, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005364 ] . obo:CL_4033155 obo:IAO_0000115 "A sensory neuron that has the soma located in the jugular ganglion and expresses the marker calcitonin gene-related peptide (CGRP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "jugular ganglion CGRP neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000101, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005364 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000027226 ] . obo:CL_4033156 obo:IAO_0000115 "A sensory neuron that has the soma located in the jugular ganglion and expresses the marker SPARC-like protein 1 (SPARCL1)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "jugular ganglion SPARCL1 neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000101, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005364 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000015476 ] . obo:CL_4033157 obo:IAO_0000115 "A sensory neuron that has the soma located in the geniculate ganglion and expresses the marker transient receptor potential vanilloid 1 (TRPV1)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "geniculate ganglion TRPV1 neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000101, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001700 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001065 ] . obo:CL_4033158 obo:IAO_0000115 "A sensory neuron that has the soma located in the geniculate ganglion and expresses the marker SPARC-like protein 1 (SPARCL1)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "geniculate ganglion SPARCL1 neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000101, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001700 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000015476 ] . obo:CL_4033159 obo:IAO_0000115 "A sensory neuron that has the soma located in the geniculate ganglion and expresses the marker vesicular glutamate transporter 2 (VGLUT2)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "geniculate ganglion VGLUT2 neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000101, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001700 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000014962 ] . obo:CL_4033160 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker choline O-acetyltransferase (ChAT)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "myenteric ganglion of small intestine ChAT neuron" ; rdfs:subClassOf obo:CL_0007011, _:genid19007, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000005404 ] . obo:CL_4033161 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "myenteric ganglion of small intestine nNOS neuron" ; rdfs:subClassOf obo:CL_0007011, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8600119 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011326 ] . obo:CL_4033162 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker vasoactive intestinal peptide (VIP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "myenteric ganglion of small intestine VIP neuron" ; rdfs:subClassOf obo:CL_0007011, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8600119 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017299 ] . obo:CL_4033163 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS) and vasoactive intestinal peptide (VIP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "myenteric ganglion of small intestine nNOS/VIP neuron" ; rdfs:subClassOf obo:CL_0007011, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8600119 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011326 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017299 ] . obo:CL_4033164 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS) and choline O-acetyltransferase (ChAT)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "myenteric ganglion of small intestine nNOS/ChAT neuron" ; rdfs:subClassOf obo:CL_0007011, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8600119 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000005404 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011326 ] . obo:CL_4033165 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker choline acetyltransferase (ChAT), calreticulin (CALR), somatostatin (SOM), and substance P (SP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "myenteric ganglion of small intestine ChAT/CALR/SOM/SP neuron" ; rdfs:subClassOf obo:CL_0007011, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8600119 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000004984 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000005404 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000015665 ] . obo:CL_4033166 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker vasoactive intestinal peptide (VIP) and galanin (GAL)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "myenteric ganglion of small intestine VIP/GAL neuron" ; rdfs:subClassOf obo:CL_0007011, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8600119 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000007806 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017299 ] . obo:CL_4033167 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker tyrosine hydroxylase (TH)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "pelvic ganglion TH neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0016508 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033168 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "pelvic ganglion TH/DBH neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0016508 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000006294 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4033169 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker vesicular acetylcholine transporter (VAChT)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "pelvic ganglion VAChT neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0016508 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000014968 ] . obo:CL_4033170 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "pelvic ganglion nNOS neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0016508 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011326 ] . obo:CL_4033171 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase (nNOS) 1 and vasoactive intestinal peptide (VIP)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "pelvic ganglion nNOS/VIP neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0016508 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011326 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000017299 ] . obo:CL_4033172 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker neuropeptide Y (NPY) and vesicular acetylcholine transporter (VAChT)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "pelvic ganglion NPY/VAChT neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0016508 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011387 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000014968 ] . obo:CL_4033173 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase 1(nNOS) and vesicular acetylcholine transporter (VAChT)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "pelvic ganglion nNOS/VAChT neuron" ; rdfs:subClassOf obo:CL_0000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0016508 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000011326 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000014968 ] . obo:CL_4033174 obo:IAO_0000115 "A peripheral nervous system neuron that has the soma located in the ovarian nerve plexus ganglion and expresses the marker tyrosine hydroxylase (TH)." ; terms:contributor ; terms:date "2025-07-22T09:18:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "ovarian nerve plexus ganglion TH neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000032, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016301 ] . obo:CL_4040000 obo:IAO_0000115 "A glial precursor cell that generates oligodendrocytes and type-1 and type-2 astrocytes. It has been shown in some mammals that this cell type may express A2B5, nestin, FGFR-1, FGFR-2, FGFR-3, PLP, and DM-20 antigens. Unlike oligodendrocyte precursor cell, it does not initially express PDGFR-alpha and can differentiate into both type-1 and type-2 astrocytes." ; terms:contributor ; terms:date "2023-04-03T14:54:32Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "glial restricted precursor" ; oboInOwl:hasExactSynonym "tripotential glial-restricted precursor cell" ; oboInOwl:hasRelatedSynonym "GRP cell" ; a owl:Class ; rdfs:label "glial restricted tripotential precursor cell" ; rdfs:subClassOf obo:CL_0000123, obo:CL_0011115 . obo:CL_4040001 obo:IAO_0000115 "A horse-specific, highly invasive trophoblast cell that invades the endometrium where it forms endometrial cups." ; obo:RO_0002175 obo:NCBITaxon_9789 ; terms:contributor ; terms:date "2023-04-03T15:08:05Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "equine chorionic girdle cell" ; a owl:Class ; rdfs:comment "Humans, mice and rats have a highly invasive (hemochorial) placentation. Horses have a non-invasive epitheliochorial placenta, except for the transient endometrial cup." ; rdfs:label "chorionic girdle cell" ; rdfs:subClassOf obo:CL_0011101 . obo:CL_4040002 obo:IAO_0000115 "Glial cell that provides support to the enteric nervous system. It is involved in enteric neurotransmission, in maintaining the integrity of the mucosal barrier of the gut and serves as a link between the nervous and immune systems of the gut. In enteric nerve strands, glial processes ensheath multiaxonal bundles which distinguishes enteric glia from all other peripheral glia. Ultrastructurally, the most conspicuous trait of an enteroglial cell is the presence of 10 nm filaments, which criss-cross the cell body, form axial bundles in the processes and appear to firmly anchor the cells to the ganglionic surfaces. Similar to astrocytes, their main constituent is glial fibrillary acidic protein (GFAP)." ; terms:contributor ; terms:date "2023-04-03T15:15:40Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "enteric glial cell" ; oboInOwl:hasRelatedSynonym "enteric glia" ; oboInOwl:inSubset cl:cellxgene_subset ; a owl:Class ; rdfs:label "enteroglial cell" ; rdfs:subClassOf obo:CL_0000125, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002005 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000007939 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002005 ] ) ] . obo:CL_4040003 obo:IAO_0000115 "Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity." ; terms:contributor ; terms:date "2023-06-02T09:19:31Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "fetal alveolar pre-type II epithelial cell", "fetal pre-type 2 pneumocyte", "fetal pre-type II alveolar epithelial cell", "fetal pre-type II pneumocyte" ; a owl:Class ; rdfs:comment "According to PMID:1316350 this cell type does not yet produce surfactant. According to PMID:9109447 and PMID:12114192 this cell type produces low levels of surfactant that can be increased by administration of very low-density lipoproteins. This cell type is of medical relevance, as a central feature of the fetal respiratory distress syndrome seems to be the presence in the lung of abundant pre-type II alveolar epithelial cells (PMID:1316350)." ; rdfs:label "fetal pre-type II pulmonary alveolar epithelial cell" ; rdfs:subClassOf obo:CL_0000322 . obo:CL_4040004 obo:IAO_0000115 "Any mesenchymal stem cell of adipose tissue that is part of an orbital region." ; terms:contributor ; terms:date "2023-09-18T10:43:00Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "OAMSC", "Orbital ASCs", "orbital adipose-derived mesenchymal stem cell" ; a owl:Class ; rdfs:label "mesenchymal stem cell of orbital adipose tissue" ; rdfs:subClassOf obo:CL_0002570, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004088 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002570 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004088 ] ) ] . obo:CL_4040005 obo:IAO_0000115 "A mesenchymal stem cell that is part of the apical papilla tooth root." ; terms:contributor ; terms:date "2023-11-02T09:44:47Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "stem cells from the apical papilla" ; oboInOwl:hasRelatedSynonym "SCAP", "SCAPs" ; a owl:Class ; rdfs:comment "The mesenchymal stem cells of the apical papilla have high capacity for osteogenic, adipogenic, and chondrogenic differentiation." ; rdfs:label "mesenchymal stem cell of apical papilla" ; rdfs:subClassOf obo:CL_0000134, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003677 ] . obo:CL_4040006 obo:IAO_0000115 "A chromatophore that is part of the dermis." ; terms:contributor ; terms:date "2024-03-07T09:37:14Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "dermal chromatophore" ; rdfs:subClassOf obo:CL_0000147, obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] . obo:CL_4042001 obo:IAO_0000115 "A GABAergic interneuron that has its soma located in the striatum and that has an enriched expression of the genes TAC3 and LHX6." ; terms:contributor ; terms:date "2024-03-05T14:29:32Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "TAC3 interneuron" ; a owl:Class ; rdfs:label "TAC3-positive striatal interneuron"@en ; rdfs:subClassOf obo:CL_0002613, obo:CL_0011005, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000016004 ] . obo:CL_4042002 obo:IAO_0000115 "A nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron that co-expresses TAC3 and the DRD1 receptor." ; terms:contributor ; terms:date "2024-03-05T13:36:54Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "D1Sh TAC3 archetype", "TAC3-positive D1Sh-MSN", "TAC3-positive MSN" ; a owl:Class ; rdfs:comment "A TAC3-positive medium spiny neuron has its soma in a cluster in the medial shell region of the nucleus accumbens. In Rhesus Macaque, this medium spiny neuron has an enriched expression of the genes MPPED1, HPCAL1, MEIS3." ; rdfs:label "TAC3-positive medium spiny neuron"@en ; rdfs:subClassOf obo:CL_4030051, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000016004 ] . obo:CL_4042003 obo:IAO_0000115 "A central nervous system macrophage that is part of a choroid plexus, a meninx and a perivascular space. A border associated macrophage interacts with various components of the CNS vasculature and meninges, it participates in immune surveillance and in the regulation of the blood brain barrier." ; terms:contributor ; terms:date "2024-03-26T16:39:56Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "BAM", "CAM", "CNS-associated macrophage" ; a owl:Class ; rdfs:comment "In humans, a border associate macrophage expresses CD45 and CD11B. This cell is also known to have the following molecular signature: CD206, CD38, LYVE1, CD163, CD169." ; rdfs:label "border associated macrophage"@en ; rdfs:subClassOf obo:CL_0000878 . obo:CL_4042004 obo:IAO_0000115 "A choroid plexus macrophage that is part of the apical surface of some choroid plexus epithelium. This macrophage has a star-like shaped body." ; terms:contributor ; terms:date "2024-03-26T19:14:58Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Kolmer’s cell" ; oboInOwl:hasRelatedSynonym "cpepiMΦ", "epiplexus cpMΦ" ; a owl:Class ; rdfs:label "choroid epiplexus macrophage"@en ; rdfs:subClassOf obo:CL_0000880, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003911 ] . obo:CL_4042005 obo:IAO_0000115 "A choroid plexus macrophage that is part of a choroid plexus stroma." ; terms:contributor ; terms:date "2024-03-26T19:21:51Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "cpstMΦ", "stromal cpMΦ" ; a owl:Class ; rdfs:label "stromal choroid plexus macrophage"@en ; rdfs:subClassOf obo:CL_0000880, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005206 ] . obo:CL_4042006 obo:IAO_0000115 "A border associated macrophage which is part of a dura matter. This macrophage phagocytoses intruding pathogens and foreign molecules detected in the bloodstream or in the cerebrospinal fluid. This cell has an amoeboid body with dynamic protrusions in homeostasis." ; terms:contributor ; terms:date "2024-03-26T19:27:03Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "dmMΦ" ; a owl:Class ; rdfs:label "dural macrophage"@en ; rdfs:subClassOf obo:CL_4042003, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002092 ] . obo:CL_4042007 obo:IAO_0000115 "An astrocyte with highly branched protrusions, found in neocortex layers 2-6. It is involved with the formation and elimination of synapses, glutamate clearance, modulation of synaptic functions and regulation of blood flow in response to synaptic activity." ; terms:contributor ; terms:date "2024-04-08T16:01:24Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "This astrocyte extends its branches to several hundred of dendrites to multiple neurons to envelope 100,000 or more synapses. In humans, a protoplasmic astrocyte has an average diameter of 142 µm, and its diameter ranges between 100 and 400 µm. In rodents the average diameter of a protoplasmic astrocites is 56 µm." ; rdfs:label "protoplasmic astrocyte"@en ; rdfs:subClassOf obo:CL_0002605, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001950 ] . obo:CL_4042008 obo:IAO_0000115 "A cell type located in the first layer of the neocortex with radial protrusions extending transversely into the deeper cortex layers, herby facilitating communication across neurons, astrocytes, capillaries, meninges and cerebrospinal fluid through contact with neurons, pia mater and capillaries." ; terms:contributor ; terms:date "2024-04-08T16:29:28Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "In humans, a fibrous astrocyte diameter is circa 182 µm. In rodents, a fibrous astrocyte diameter is circa 85 µm." ; rdfs:label "fibrous astrocyte"@en ; rdfs:subClassOf obo:CL_0000127, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002316 ] . obo:CL_4042009 obo:IAO_0000115 "An astrocyte type that presents radial protrusions across the layers of a cortex. The soma of this astrocyte is part of the first layer of a neocortex. This astrocyte extents its protrusions transversally to the deeper layers of a cortex and it creates contact with neurons, the pia matter and capillaries. This astrocyte is involved in facilitating the communication across neurons, astrocytes, capillaries, meninges and the cerebrospinal fluid." ; terms:contributor ; terms:date "2024-04-08T16:33:45Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "ILA" ; a owl:Class ; rdfs:label "interlaminar astrocyte"@en ; rdfs:subClassOf obo:CL_0002605, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001950 ] . obo:CL_4042010 obo:IAO_0000115 "An interlaminar astrocyte whose soma is part of the first layer of a neocortex and is in contact with a pia surface." ; terms:contributor ; terms:date "2024-04-08T16:37:57Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "pial interlaminar astrocyte"@en ; rdfs:subClassOf obo:CL_4042009 . obo:CL_4042011 obo:IAO_0000115 "An interlaminar astrocyte type whose soma is part of the upper first layer of the neocortex and its processes extend to a pia surface." ; terms:contributor ; terms:date "2024-04-08T16:39:09Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "subpial interlaminar astrocyte"@en ; rdfs:subClassOf obo:CL_4042009, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0002361 ] . obo:CL_4042012 obo:IAO_0000028 "L2MN" ; obo:IAO_0000115 "An L2 intratelencephalic projecting glutamatergic neuron with a soma on the L1-L2 border. This neuron type has small apical dendrites projecting to L1." ; terms:contributor ; terms:date "2024-04-23T09:31:39Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "layer 2 marginal neuron" ; oboInOwl:hasRelatedSynonym "L2MN" ; a owl:Class ; rdfs:label "L2 marginal neuron"@en ; rdfs:subClassOf obo:CL_4030060 . obo:CL_4042013 obo:IAO_0000115 "A transcriptomically distinct lamp5 GABAergic cortical interneuron located in the cerebral cortex that expresses Lamp5 and Lhx6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', Lamp5 Lhx6." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2024-04-23T09:37:55Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Ivy cell", "Lamp5-Lhx6 type" ; a owl:Class ; rdfs:comment "The marker set CHST9, LAMP5 can identify the Human cell type Lamp5 Lhx6 neuron in the neocortex with a confidence of 0.821678322 (NS-Forest FBeta value)." ; rdfs:label "Lamp5 Lhx6 neuron"@en ; rdfs:subClassOf obo:CL_4023011, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000032533 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000075 ] . obo:CL_4042014 obo:IAO_0000115 "A VIP GABAergic cortical interneuron with a soma located in L1-3 of some neocortex in Mmus. This neuron has a multipolar morphology with spiny dendrites concentrating on L1 of the cortex, and has a burst firing electrophysiological signature with highly dynamic dendritic spines." ; terms:contributor ; terms:date "2024-07-11T12:09:53Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "superficial VIP-positive spiny neuron" ; oboInOwl:hasRelatedSynonym "multipolar VIP neuron" ; a owl:Class ; rdfs:label "spiny VIP neuron"@en ; rdfs:subClassOf obo:CL_4023016, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001950 ] . obo:CL_4042015 obo:IAO_0000115 "A VIP GABAergic cortical interneuron expressing vasoactive intestinal polypeptide and choline acetyltransferase in the Mmus neocortex. This interneuron releases both γ-aminobutyric acid and acetylcholine." ; terms:contributor ; terms:date "2024-07-11T12:22:48Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "VIP+/ChAT+ interneuron", "VIP/ChAT interneuron" ; oboInOwl:hasRelatedSynonym "VChI", "VIP+/ChAT+ cell" ; a owl:Class ; rdfs:comment "Work in the mouse barrel cortex and somatosensory cortex shows that a VIP-ChAT interneuron is predominantely located in L2/3 and more rarely in the deeper layers of the cortex (Dudai et al., 2021; Dudai et al., 2020). This neuronal type could be transcriptomically distinct as transcriptomic studies have identified VIP neurons expressing ChAT in a whole brain mouse transcriptomic study (Tasic et al., 2018)." ; rdfs:label "VIP-ChAT interneuron"@en ; rdfs:subClassOf obo:CL_0008061, obo:CL_4023016 . obo:CL_4042016 obo:IAO_0000115 "A serous secreting cell that is part of a submucosal gland in the nasal cavity respiratory epithelium." ; terms:contributor ; terms:date "2024-07-12T10:58:06Z"^^xsd:dateTime ; oboInOwl:hasDbXref "https://cellxgene.cziscience.com/e/9f222629-9e39-47d0-b83f-e08d610c7479.cxg/" ; oboInOwl:hasRelatedSynonym "nasal mucous secretory cell" ; a owl:Class ; rdfs:label "nasal serous secreting cell"@en ; rdfs:subClassOf obo:CL_0000152, obo:CL_0000313, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005385 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011148 ] . obo:CL_4042017 obo:IAO_0000115 "The dorsal-most tanycyte type of the third venticle. These cells projects into the ventromedial or dorsomedial nucleus of the hypothalamus. This type of tanycyte extends its protrusions close to parenchymal neurons without contacting blood vessels. It expresses the glial marker S-100β." ; terms:contributor ; terms:date "2024-08-19T13:06:16Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "DMH tanycyte", "VMH tanycyte" ; a owl:Class ; rdfs:comment "In rodents, a1 tanycytes are known to express DARPP-32, GPR50, NA Vimentin, Connexin 43, GLT-1, GLUT1(+) (Goodman and Hajihosseini 2015; Prevot et al., 2018)." ; rdfs:label "alpha1-tanycyte"@en ; rdfs:subClassOf obo:CL_0002085, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004642 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000014419 ] ; foaf:depiction , . obo:CL_4042018 obo:IAO_0000115 "Tanycyte of the third ventricle, located immediately ventral to alpha-1 tanycytes. These cells project to the ventromedial and arcuate nuclei of the hypothalamus and express the glial marker S-100β." ; terms:contributor ; terms:date "2024-08-19T13:13:20Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "dmARH tanycyte" ; a owl:Class ; rdfs:comment "In rodents, this type of tanycyte is more developmentally advanced than alpha1 tanycytes, shows a high neurogenic competence and expresses the following markers DARPP-32, Vimentin, GPR50, Connexin-43, GLT-1, GLUT1(+) (Goodman and Hajihosseini 2015; Prevot et al., 2018)" ; rdfs:label "alpha2-tanycyte"@en ; rdfs:subClassOf obo:CL_0002085, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000014419 ] ; foaf:depiction , . obo:CL_4042019 obo:IAO_0000115 "A type of tanycyte located in ventral part of the lateral wall of the third ventricle and in the lateral infundibular recess of the brain. This tanycyte has an elongated morphology with multiple microvilli extending into the median eminence. This type of tanycyte expresses FGF receptors 1 and 2, is in contact with GnRH neurons, and is involved in the release of gonadotropin-releasing hormone (GnRH)." ; terms:contributor ; terms:date "2024-08-19T13:17:32Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "vmARH tanycyte" ; a owl:Class ; rdfs:label "beta1-tanycyte"@en ; rdfs:subClassOf obo:CL_0002085, obo:CL_1100001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006250 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002197 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032274 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000007479 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000007489 ] ; foaf:depiction , . obo:CL_4042020 obo:IAO_0000115 "A type of tanycyte located in the floor of third ventricle and the infindibular recess. This tanycyte has an elongated morphology with multiple microvilli extending medially and ventrally to the median eminence, contacting the pial surface and blood vessels. This type of tanycyte expresses FGF receptors 1 and 2, is in contact with GnRH neurons, and is involved in the release of gonadotropin-releasing hormone (GnRH)." ; terms:contributor ; terms:date "2024-08-19T13:21:39Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "ME tanycyte" ; a owl:Class ; rdfs:label "beta2-tanycyte"@en ; rdfs:subClassOf obo:CL_0002085, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006250 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002197 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000007479 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000007489 ] ; foaf:depiction , . obo:CL_4042021 obo:IAO_0000115 "A progenitor cell of the central nervous system that differentiates exclusively onto neurons. This progenitor cell is found in a hippocampus subventricular zone, developing cortex and spinal cord of the central nervous system." ; terms:contributor ; terms:date "2024-09-02T11:42:12Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "NRP" ; a owl:Class ; rdfs:comment "In vitro cultures of embryonic mouse neural tubes show that neuronal-restricted precursors (NRPs) are derived from multipotent neuroepithelial cells to give rise to neurons. This progression suggests a linear relationship between multipotent progenitors and neuronal-restricted differentiation. (Mayer-Proschel et al., 1997). In the spinal cord of rats, neural-restricted precursor cells give rise cholinergic, GABAergic, glutametergic neurons (Cao and Howard et al., 2002)." ; rdfs:label "neuronal-restricted precursor"@en ; rdfs:subClassOf obo:CL_0000123, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] . obo:CL_4042022 obo:IAO_0000115 "A progenitor cell of the central nervous system that differentiates exclusively onto astrocytes. This progenitor cell expresses CD44 and S100 calcium-binding protein B." ; terms:contributor ; terms:date "2024-09-02T11:44:45Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "ARP", "astrocyte precursor cell" ; a owl:Class ; rdfs:comment "In vitro, this progenitor cell can differentiate from glial-restricted precursor cells." ; rdfs:label "astrocyte-restricted precursor"@en ; rdfs:subClassOf obo:CL_0000123, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000127 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001307 ] . obo:CL_4042023 obo:IAO_0000115 "A GABAergic interneuron expressing PTHLH and PVALB that has its soma in a striatum. This GABAergic interneuron type presents a spatial expression gradient of PVALB in the mouse striatum." ; terms:contributor ; terms:date "2024-09-17T10:20:15Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "PTHLH/PVALB cell", "PTHLH +/PVALB+ interneuron" ; a owl:Class ; rdfs:comment "According to spatial transcriptomic data in the human striatum, pthlh-expressing interneurons are one of the most abundant population of interneurons in the striatum (Leonardo D. Garma, et al., 2024)." ; rdfs:label "striatal pthlh-expressing interneuron"@en ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0002613, obo:CL_0011005, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000013433 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000013502 ] . obo:CL_4042024 obo:IAO_0000115 "A pthlh-expressing interneuron that expresses MOXD1 and has its soma in a striatum." ; terms:contributor ; terms:date "2024-09-17T10:26:57Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "striatal PTHLH MOXD1 expressing interneuron"@en ; rdfs:subClassOf obo:CL_4042023, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000010529 ] . obo:CL_4042025 obo:IAO_0000115 "A midbrain dopaminergic neuron that has its soma located in a substantia nigra. This dopaminergic neuron type is highly metabolically active and it is involved in the regulation of movement, cognition, motivation and reward. Neurodegeneration of this dopaminergic neuronal type causes loss in fine motor control in Parkinson's Disease." ; terms:contributor ; terms:date "2024-09-16T13:09:29Z"^^xsd:dateTime ; oboInOwl:hasNarrowSynonym "SNpc dopaminergic neuron" ; a owl:Class ; rdfs:label "substantia nigra dopaminergic neuron"@en ; rdfs:subClassOf obo:CL_0002614, obo:CL_2000097 . obo:CL_4042026 obo:IAO_0000115 "A GABAergic interneuron that has its soma in the anterior section of the substantia nigra pars reticulata. This GABAergic interneuron is characterized by the expression of Six3 and Foxp1 and it develops from Nkx6-2 expressing neuronal progenitors in the ventrolateral midbrain-diencephalon region." ; terms:contributor ; terms:date "2024-09-23T13:56:01Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "aSNpr" ; a owl:Class ; rdfs:label "GABAergic interneuron of the anterior substantia nigra pars reticulata"@en ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0002614, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000007643 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000013047 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000014898 ] . obo:CL_4042027 obo:IAO_0000115 "A GABAergic interneuron that has its soma in the posterior section of the substantia nigra pars reticulata. This GABAergic interneuron is characterised by the expression of the transcription factors Pax5, Ctip2 and Pou6f2 and it develops from the ventrolateral r1 neuroepithelium expresing NKX61." ; terms:contributor ; terms:date "2024-09-23T14:49:11Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "pSNpr" ; a owl:Class ; rdfs:label "GABAergic interneuron of the posterior substantia nigra pars reticulata"@en ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0002614, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000001903 ] . obo:CL_4042028 obo:IAO_0000115 "A neuron in the central nervous system that is not committed to a differentiated fate, has not been newly derived from neurogenesis, and does not integrate into any circuit." ; terms:contributor ; terms:date "2024-10-10T09:14:45Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "IN" ; a owl:Class ; rdfs:comment "It is hypothesised that immature neurons can be utilised as a neurogenic reserve and that they can be involved in circuit plasticity." ; rdfs:label "immature neuron"@en ; rdfs:subClassOf obo:CL_2000029 . obo:CL_4042029 obo:IAO_0000115 "An immature neuron of a cerebral cortex. This neuron develops prenatally and remains in an immature state throughout the lifespan of the organism." ; terms:contributor ; terms:date "2024-10-10T09:14:54Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "cIN" ; a owl:Class ; rdfs:label "cortical immature neuron"@en ; rdfs:subClassOf obo:CL_0010012, obo:CL_4042028, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000956 ] . obo:CL_4042030 obo:IAO_0000115 "A GABAergic interneuron located in the Purkinje layer of the cerebellar cortex. This GABAergic interneuron type has a distinct morphology, it presents a small cell soma near the Purkinje cell layer (PCL), dendrites that extend to the surface of the molecular layer, and beaded axons that make local synapses contacts within the molecular layer. A candelabrum cell is excited by mossy fibers and granule cells but inhibited by Purkinje cells, and it inhibits molecular layer interneurons, which leads to the disinhibition of Purkinje cells." ; terms:contributor ; terms:date "2024-10-15T11:06:31Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "candelabrum interneuron" ; oboInOwl:hasRelatedSynonym "CC" ; a owl:Class ; rdfs:comment "Candelabrum cells are the most abundant interneurons in the Purkinje cell layer and are present in all cerebellar lobules." ; rdfs:label "candelabrum cell"@en ; rdfs:subClassOf obo:CL_4072102 ; foaf:depiction . obo:CL_4042031 obo:IAO_0000115 "An oligodendrocyte of the central nervous system that exhibits immune properties such as self-presentation and non-self antigen presentation to T cells, phagocytosis of debris, and cytokine and chemokine production. Immune oligodendroglia is immunoreactive during inflammation, neurodegenerative disorders, chronic stress and major depressive disorder." ; terms:contributor ; terms:date "2024-10-11T12:51:17Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "immune oligodendrocyte" ; oboInOwl:hasRelatedSynonym "Im-OL", "ImOL", "ImOLG", "imOLG" ; a owl:Class ; rdfs:comment "During inflammation, immuno oligodendroglia express MHC II to interact with immune cells in mouse models (Harrington et al., 2023; Madeira et al., 2022). In a mouse model of major depressive disorder and chronic stress, immuno oligodendroglia were associated with prefrontal cortex hypomyelination (Kokkosis et al., 2022)." ; rdfs:label "immune oligodendroglia"@en ; rdfs:subClassOf obo:CL_0000128, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002504 ] . obo:CL_4042032 obo:IAO_0000115 "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses the transcript PAX6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters PAX6." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor ; terms:date "2024-10-11T13:25:51Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "The marker set RELN, HCRTR2 can identify the Human cell type PAX6 GABAergic cortical interneuron in the neocortex with a confidence of 0.724125093 (NS-Forest FBeta value)." ; rdfs:label "PAX6 GABAergic cortical interneuron"@en ; rdfs:subClassOf obo:CL_4023064, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000012318 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015004 ; owl:someValuesFrom obo:CLM_1000079 ] . obo:CL_4042033 obo:IAO_0000115 "A neuron of the central nervous system that expresses POMC and synthesizes the POMC precursor polypeptide. This neuron type is located in the arcuate nucleus of the hypothalamus and in the nucleus tractus solitarius of the brainstem. The pro-opiomelanocortin neuron is part of the central melanocortin system and it is involved in regulating energy homeostasis, metabolism, and appetite. This neuronal type responds to hormonal signals such as levels of leptin and insulin, and its activation results in the release of α-melanocyte-stimulating hormone (α-MSH), which acts on melanocortin receptors to suppress food intake and increase energy expenditure." ; terms:contributor ; terms:date "2024-10-15T10:17:41Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "POMC neuron", "POMC-expressing neuron" ; a owl:Class ; rdfs:comment "Pro-opiomelanocortin neurons have a diverse projection pattern. The neurons in the rostral arcuate nucleus project to autonomic areas, caudal arcuate POMC neurons project mainly to hypothalamic areas (Toda et al., 2017). Dysregulation of pro-opiomelanocortin neurons is associated with obesity and metabolic disorders (Quarta et al., 2020)." ; rdfs:label "pro-opiomelanocortin neuron"@en ; rdfs:subClassOf obo:CL_0000165, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000013015 ] . obo:CL_4042034 obo:IAO_0000115 "An interneuron neuron characterized by the expression of calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide. This neuron type is involved in nociception and pain modulation by facilitating the transmission of nociceptive signals from peripheral sensory nerve endings to central nervous system structures. This neuron type is found in the dorsal root ganglia (DRG) and trigeminal ganglion, and the spinal cord dorsal horn." ; terms:contributor ; terms:date "2024-10-30T15:35:08Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Calcitonin gene-related peptide neuron" ; oboInOwl:hasRelatedSynonym "CGRP-expressing interneuron", "CGRP-positive neuron" ; a owl:Class ; rdfs:label "CGRP-expressing neuron"@en ; rdfs:subClassOf obo:CL_0000526, obo:CL_2000029 . obo:CL_4042035 obo:IAO_0000115 "A type of cerebellar inhibitory GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell type inhibits Purkinje cells and other molecular layer interneurons. This interneuron plays a crucial role in regulating cerebellar output through feedforward inhibition and is characterized by its fast-spiking properties." ; terms:contributor ; terms:date "2024-10-31T15:55:31Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "MLI" ; a owl:Class ; rdfs:label "molecular layer interneuron"@en ; rdfs:subClassOf obo:CL_4023057, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002974 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002974 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ) ] . obo:CL_4042036 obo:IAO_0000115 "A neuron of the central nervous system with its soma primarily located in the lateral hypothalamic area and surrounding regions, including the zona incerta. This neuron type expresses melanin-concentrating hormone and is involved in regulating various physiological processes, including sleep, feeding behavior, and energy homeostasis." ; terms:contributor ; terms:date "2024-10-31T16:03:26Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "MCH neuron" ; a owl:Class ; rdfs:comment "Nearly all melanin-concentrating hormone neurons express the glutamate transporter VGlut2, however a small subset of them expresses the machinery for GABA release and neurotransmission." ; rdfs:label "melanin-concentrating hormone neuron"@en ; rdfs:subClassOf obo:CL_2000029 . obo:CL_4042037 obo:IAO_0000115 "A interneuron of the striatum expressing gamma-aminobutyric acid and somatostatin. This interneuron has a fusiform soma with a diameter between 9 - 25 µm, it has a long axon up to the length of 1mm. This neuron type displays a low threshold Ca2+ spike (LTS), a high input resistance, and the expression of long-lasting plateau potentials following depolarization from rest." ; terms:contributor ; terms:date "2024-11-27T18:33:46Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "SOM cell" ; oboInOwl:hasRelatedSynonym "striatal SST+ IN" ; a owl:Class ; rdfs:comment "Some striatal SST GABAergic neurons can co-release glutamate and generate excitation-inhibition responses in postsynaptic neurons. This interneuron type has the least dense dendritic branches in the striatum. In the dorsomedial striatum these neurons regulate the activity of striatal projection neurons." ; rdfs:label "sst GABAergic neuron of the striatum"@en ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000617, obo:CL_0002613, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000015665 ] . obo:CL_4042038 obo:IAO_0000115 "A type of primary motor neuron situated in the rostral region of the spinal cord. RoP neurons extend their axons to innervate the ventral trunk musculature." ; terms:contributor ; terms:date "2024-11-13T13:42:01Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "RoP" ; a owl:Class ; rdfs:label "rostral primary motorneuron"@en ; rdfs:subClassOf obo:CL_0000533 . obo:CL_4042039 obo:IAO_0000115 "A neuron of the central nervous system that develops from a caudal ganglionic eminence." ; terms:contributor ; terms:date "2024-11-14T11:27:25Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Neurons derived from the caudal ganglionic eminence consist mostly of neurons populating the cortical layers of the brain and some subcortical areas such as the globus pallidus, the striatus and the hippocampus. Amongst neurons derived from the caudal ganglionic eminence there are cortical GABAergic neurons such as Pax6, Lamp5, VIP, sncg, GABAergic; in the hippocampus, mossy fibers, pyramidal neurons, granule neurons and interneurons; in the striatum and globus pallidus, medium spiny projection neurons." ; rdfs:label "caudal ganglionic eminence derived neuron"@en ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004026 ] . obo:CL_4042040 obo:IAO_0000115 "A glutametergic neuron with its soma located in a basal ganglia. This neuron type is involved in motor control, decision making and learning." ; terms:contributor ; terms:date "2024-11-18T13:37:58Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "The glutametergic neurons in the basal ganglia are part of a series of different circuits such as the corticolstriatal circuit, which is involved in regulating voluntary movements. The subthalamic nucleus circuit, which is involved in modulating the output of the basal ganglia, particularly in controlling movement initiation and inhibition. The thalamocortical loop, which is involved in refining motor movements and integrating sensory information with motor commanding." ; rdfs:label "glutamatergic neuron of the basal ganglia"@en ; rdfs:subClassOf obo:CL_0000679, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002420 ] . obo:CL_4042041 obo:IAO_0000115 "A type of primary motor neuron located in the middle region of the spinal cord. This primary motor neuron type is characterized by their distinct axonal pathways that innervate the middle trunk muscles." ; terms:contributor ; terms:date "2024-11-13T13:39:28Z"^^xsd:dateTime ; oboInOwl:hasDbXref "ZFA:0005179" ; oboInOwl:hasRelatedSynonym "MiP" ; a owl:Class ; rdfs:label "middle primary motoneuron"@en ; rdfs:subClassOf obo:CL_0000533 . obo:CL_4047001 obo:IAO_0000115 "A(n) stromal cell that is cycling." ; oboInOwl:hasExactSynonym "proliferating stromal cell" ; a owl:Class ; rdfs:label "cycling stromal cell" ; rdfs:subClassOf obo:CL_0000499, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4047002 obo:IAO_0000115 "A(n) glial cell that is cycling." ; oboInOwl:hasExactSynonym "proliferating glial cell" ; a owl:Class ; rdfs:label "cycling glial cell" ; rdfs:subClassOf obo:CL_0000125, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4047003 obo:IAO_0000115 "A(n) plasma cell that is cycling." ; oboInOwl:hasExactSynonym "proliferating plasma cell" ; a owl:Class ; rdfs:label "cycling plasma cell" ; rdfs:subClassOf obo:CL_0000786, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000786 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4047004 obo:IAO_0000115 "A(n) type EC enteroendocrine cell that is cycling." ; oboInOwl:hasExactSynonym "proliferating type EC enteroendocrine cell" ; a owl:Class ; rdfs:label "cycling type EC enteroendocrine cell" ; rdfs:subClassOf obo:CL_0000577, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000577 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4047005 obo:IAO_0000115 "A(n) neuroblast (sensu Vertebrata) that is cycling." ; oboInOwl:hasExactSynonym "proliferating neuroblast (sensu Vertebrata)" ; a owl:Class ; rdfs:label "cycling neuroblast (sensu Vertebrata)" ; rdfs:subClassOf obo:CL_0000031, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000031 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0022402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002354 ] ) ] . obo:CL_4047006 obo:IAO_0000115 "An endothelial cell that lines an artery in the fetal circulatory system." ; terms:contributor ; terms:date "2024-08-16T13:52:25Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "endothelial cell of fetal artery", "fetal arterial EC", "fetal artery EC" ; a owl:Class ; rdfs:label "fetal artery endothelial cell" ; rdfs:subClassOf obo:CL_1000413 . obo:CL_4047007 obo:IAO_0000115 "A pericyte that is in an early stage of development, found in newly forming or remodeling blood vessels. An immature pericyte is characterized by it's mesenchymal stem cell-like properties and high proliferative capacity, which allows it to differentiate into various types of pericytes and contribute to the structural and functional maturation of the vasculature. Immature pericytes are stellate in new vessels and elongated with less protrusions in remodeling vessels." ; terms:contributor ; terms:date "2024-08-19T11:32:32Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "imPCs", "immature PCs" ; a owl:Class ; rdfs:label "immature pericyte" ; rdfs:subClassOf obo:CL_0000669 . obo:CL_4047011 obo:IAO_0000115 "An endothelial cell that lines the veins in the fetal circulatory system." ; terms:contributor ; terms:date "2024-09-05T15:45:32Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "fetal venous endothelial cell" ; oboInOwl:hasRelatedSynonym "fetal vein EC", "fetal venous EC" ; a owl:Class ; rdfs:label "fetal vein endothelial cell"@en ; rdfs:subClassOf obo:CL_0002543 . obo:CL_4047012 obo:IAO_0000115 "A specialized pericyte that actively participates in the formation of new blood vessels during angiogenesis by undergoing phenotypic changes, increasing proliferation, and interacting closely with endothelial cells." ; terms:contributor ; terms:date "2024-09-06T08:41:39Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "angiogenic pericyte"@en ; rdfs:subClassOf obo:CL_0000669 . obo:CL_4047017 obo:IAO_0000115 "A transit amplifying cell of the gut epithelium, located in the wall of the intestinal crypt, just above intestinal stem cells from which they derive. These are rapidly dividing cells, capable of multiple rounds of division before differentiating into the various cell types of the gut epithelium (enterocyte, goblet, eneterodendocrine, paneth cells)." ; terms:contributor ; terms:date "2024-09-24T10:48:47Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "transit-amplifying cell" ; oboInOwl:hasRelatedSynonym "TA cell" ; a owl:Class ; rdfs:label "transit amplifying cell of gut"@en ; rdfs:subClassOf obo:CL_0002563, obo:CL_0009010, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013740 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002207 ; owl:someValuesFrom obo:CL_0002250 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0009010 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013740 ] ) ] . obo:CL_4047018 obo:IAO_0000115 "An enterocyte that is part of the colon, in the early stages of differentiation, located in the intestinal crypt-villus axis." ; terms:contributor ; terms:date "2024-09-24T11:50:13Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "early enterocyte of colon" ; a owl:Class ; rdfs:label "early colonocyte"@en ; rdfs:subClassOf obo:CL_1000347, obo:CL_4047019 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4047019 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000397 ] ) ] . obo:CL_4047019 obo:IAO_0000115 "An enterocyte in the early stages of development, located above the transit-amplifying cell zone in the intestinal crypt-villus axis." ; terms:contributor ; terms:date "2024-09-24T12:11:09Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "early enterocyte"@en ; rdfs:subClassOf obo:CL_0000584, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013740 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000584 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013740 ] ) ] . obo:CL_4047023 obo:IAO_0000115 "A fibroblast located in the lamina propria of the intestinal mucosa. This cell expresses PDGFRα and CD81 and is negative for α-smooth muscle actin (α-SMA). This cell is predominantly located in the small intestine adjacent to myofibroblasts surrounding the crypts. It is capable of synthesizing extracellular matrix components and structural proteins such as collagen and elastin." ; terms:contributor ; terms:date "2024-09-24T15:45:18Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "S1 fibroblast" ; a owl:Class ; rdfs:label "intestinal lamina propria fibroblast"@en ; rdfs:subClassOf obo:CL_0000057, obo:CL_0000151, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004780 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070278 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004780 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070278 ] ) ] . obo:CL_4047025 obo:IAO_0000115 "Any type G enteroendocrine cell that is part of some epithelium of stomach." ; terms:contributor ; terms:date "2024-10-24T10:43:22Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "type G cell of stomach"@en ; rdfs:subClassOf obo:CL_0000508, obo:CL_1000222 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000508 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001276 ] ) ] . obo:CL_4047029 obo:IAO_0000115 "An endothelial cell forming the walls of capillaries immediately downstream from arterioles, facilitating the exchange of substances between blood and interstitial fluid. This cell is characterized by a small diameter and may be continuous, fenestrated, or sinusoidal, depending on their location and function. This cell plays a crucial role in tissue oxygenation, nutrient delivery, and maintaining homeostasis within the microvascular network." ; terms:contributor ; terms:date "2024-11-07T12:50:06Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "post-arteriole capillary cell"@en ; rdfs:subClassOf obo:CL_0002144 . obo:CL_4047030 obo:IAO_0000115 "A specialized endothelial cell located in the transition zone between capillaries and small venules in the microvascular system. It exhibits characteristics of both capillary and venous cells, expressing markers from both types. This cell plays a role in regulating blood flow and substance exchange between blood and tissues." ; terms:contributor ; terms:date "2024-11-07T13:22:16Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Cap-Venous endothelial cell" ; a owl:Class ; rdfs:label "pre-venule capillary cell"@en ; rdfs:subClassOf obo:CL_0002144 . obo:CL_4047032 obo:IAO_0000115 "A specialized pericyte located within the basement membrane of a blood capillary. This cell is characterized by its ability to produce and release a variety of bioactive molecules, collectively known as the pericyte secretome, including cytokines and regulators of angiogenesis." ; terms:contributor ; terms:date "2024-11-07T15:36:16Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "secretory pericyte"@en ; rdfs:subClassOf obo:CL_0000151, obo:CL_0000669, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045765 ] . obo:CL_4047034 obo:IAO_0000115 "A smooth muscle cell that is part of the muscularis externa of the stomach wall. It is characterized by its fusiform shape, involuntary control, and ability to generate slow, sustained contractions. This cell is organized in distinct layers and is essential for gastric motility and digestion." ; terms:contributor ; terms:date "2024-12-05T11:10:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "smooth muscle cell of stomach"@en ; rdfs:subClassOf obo:CL_0000192, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008856 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008856 ] ) ] . obo:CL_4047035 obo:IAO_0000115 "A specialized smooth muscle cell located in the outermost layer of the muscularis externa of the stomach wall. This cell is arranged longitudinally along the stomach's axis and is responsible for the contractions that facilitate food movement toward the pylorus." ; terms:contributor ; terms:date "2024-12-05T16:13:49Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "stomach smooth muscle outer longitudinal layer cell"@en ; rdfs:subClassOf obo:CL_4047034 . obo:CL_4047036 obo:IAO_0000115 "A smooth muscle cell located in the middle layer of the muscularis externa of the stomach wall. This cell is arranged concentrically with the stomach's longitudinal axis, forming a continuous sheet of contractile tissue. It is fusiform in shape, containing actin and myosin filaments that enable contraction without striations. This cell contributes to the mechanical digestion and movement of food within the stomach through coordinated contractions, and plays a role in forming the pyloric sphincter in the pyloric region." ; terms:contributor ; terms:date "2024-12-09T10:40:58Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "stomach smooth muscle circular layer cell"@en ; rdfs:subClassOf obo:CL_4047034, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008857 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008857 ] ) ] . obo:CL_4047037 obo:IAO_0000115 "A smooth muscle cell found in the innermost layer of the muscularis externa of the stomach wall. This cell forms a unique layer of smooth muscle fibers oriented obliquely to the stomach's longitudinal axis. It is responsible for aiding in the mixing and churning of gastric contents, contributing to mechanical digestion within the stomach." ; terms:contributor ; terms:date "2024-12-09T10:53:19Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "stomach smooth muscle oblique layer cell" ; a owl:Class ; rdfs:label "stomach smooth muscle inner oblique layer cell"@en ; rdfs:subClassOf obo:CL_4047034, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008862 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008862 ] ) ] . obo:CL_4047038 obo:IAO_0000115 "A multipolar neuron in the myenteric plexus of the gastrointestinal tract, characterized by a small to medium-sized cell body and multiple short dendrites. This neuron exhibits fast excitatory postsynaptic potentials and can be classified into stubby, spiny and hairy subtypes based on dendritic morphology. (Brehmer, 2021)" ; terms:contributor ; terms:date "2024-12-16T13:42:04Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "dogiel type I neuron" ; rdfs:subClassOf obo:CL_0000104, obo:CL_0007011, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002439 ] . obo:CL_4047040 obo:IAO_0000115 "A smooth muscle cell that is found in the inner muscular layer of hollow organs. It is characterized by its spiral/helical arrangement around organ lumens. This cell is crucial for peristaltic movements in organs." ; terms:contributor ; terms:date "2025-01-06T15:40:21Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "smooth muscle circular layer cell" ; rdfs:subClassOf obo:CL_0000192, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012368 ] . obo:CL_4047042 obo:IAO_0000115 "An enteric glial cell located within the myenteric ganglia of the gastrointestinal tract. This cell has a small somata and has very short, irregularly branched processes that surround neuron cell bodies, giving it a protoplasmic-like appearance. It plays crucial roles in modulating myenteric neuron activity, regulating oxidative stress, and influencing neuroinflammation and neurogenesis." ; terms:contributor ; terms:date "2025-02-10T16:49:55Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "type 1 MP" ; a owl:Class ; rdfs:label "type 1 myenteric plexus glia" ; rdfs:subClassOf obo:CL_4040002, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002439 ] . obo:CL_4047043 obo:IAO_0000115 "An enteric glial cell that is associated with neuron cell bodies within submucosal ganglia of the gastrointestinal tract. This cell is located in the submucosa, a layer of connective tissue beneath the intestinal mucosa. This cell plays a role in modulating secretomotor neuron activity and contributes to the regulation of digestive fluid secretion and absorption." ; terms:contributor ; terms:date "2025-02-10T17:02:28Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "type I SMP" ; a owl:Class ; rdfs:label "type 1 submucosal plexus glia" ; rdfs:subClassOf obo:CL_4040002, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009566 ] . obo:CL_4047044 obo:IAO_0000115 "An enteric glial cell that has an elongated, fibrous morphology with long processes that run parallel to nerve fibers connecting enteric myenteric ganglia. This cell is located in the interganglionic fiber tracts of the enteric nervous system." ; terms:contributor ; terms:date "2025-02-11T12:28:37Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "type II enteric glia" ; a owl:Class ; rdfs:label "type 2 interganglionic glia" ; rdfs:subClassOf obo:CL_4040002, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000429 ] . obo:CL_4047045 obo:IAO_0000115 "An enteric glial cell located in the lamina propria of the intestinal mucosa. This cell plays important roles in maintaining gut barrier function, regulating intestinal homeostasis, and mediating interactions between the enteric nervous system and the immune system." ; terms:contributor ; terms:date "2025-02-11T12:39:11Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "type 3 mucosal glia" ; rdfs:subClassOf obo:CL_4040002, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000030 ] . obo:CL_4047047 obo:IAO_0000115 "An enteric glial cell located within the ganglia of the enteric nervous system. This cell is characterized by it’s small somata and short, irregularly branched processes that surround neuronal cell bodies in the myenteric and submucosal ganglia. This cell plays important roles in modulating neuronal activity and neurogenesis in the gastrointestinal tract." ; terms:contributor ; terms:date "2025-02-11T13:35:14Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "intraganglionic glia", "type 1 enteric glia", "type I enteric glia" ; a owl:Class ; rdfs:label "type I enteric glial cell" ; rdfs:subClassOf obo:CL_4040002, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001809 ] . obo:CL_4047048 obo:IAO_0000115 "An enteric glial cell characterized by a small central soma that extends long, thin, bipolar projections. This cell is primarily located along small nerve fibers within the muscle layers of the gastrointestinal tract and is known for its unbranching processes that closely follow these nerve fibers in the muscularis." ; terms:contributor ; terms:date "2025-02-18T11:14:25Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "intramuscular glia" ; a owl:Class ; rdfs:label "type 4 muscularis propria glia" ; rdfs:subClassOf obo:CL_4040002, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006660 ] . obo:CL_4047051 obo:IAO_0000115 "An enterocyte of the human small intestine expressing bestrophin-4 (BEST4) calcium-activated ion channels. These enterocytes have a disinctive transcriptomic profile and are scattered through the small intestine epithelium." ; terms:contributor ; terms:date "2024-07-25T13:05:50Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "small intestine BEST4+ enterocyte" ; rdfs:subClassOf obo:CL_1000334, obo:CL_4030026 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000584 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001902 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_Q8NFU0 ] ) ] . obo:CL_4047052 obo:IAO_0000115 "An enterocyte of the human colon expressing bestrophin-4 (BEST4) calcium-activated ion channels. These cells have a distinct transcriptomic profile compared to other enterocytes and are scattered through the colon epithelium." ; terms:contributor ; terms:date "2024-07-25T13:21:19Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "BEST4+ colonocyte" ; rdfs:subClassOf obo:CL_1000347, obo:CL_4030026 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000347 [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_Q8NFU0 ] ) ] . obo:CL_4047053 obo:IAO_0000115 "A macrophage characterized by high expression of Triggering Receptor Expressed on Myeloid cells 2 (TREM2), found in various tissues including the liver, adipose tissue, bone, gut (Colonna, 2023), and tumor microenvironments, where it is associated with immunosuppressive and anti-inflammatory activity (Colmenares, 2024; Khantakova, 2022). This cell exhibits a distinct gene expression profile in the tumor microenvironment, including overexpression of complement system genes (C1QA, C1QB, C1QC, C3), and SPP1 in both mice and humans (Xiong, 2020; Khantakova, 2022). It is involved in phagocytosis, tissue repair, and modulation of immune responses (Coeho, 2021)." ; terms:contributor ; terms:date "2025-03-17T17:20:08Z"^^xsd:dateTime ; oboInOwl:hasNarrowSynonym "TREM-2 + resident macrophage", "TREM2+ macrophage" ; a owl:Class ; rdfs:label "TREM2-positive macrophage" ; rdfs:subClassOf obo:CL_0000235, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016626 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000235 [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000016626 ] ) ] . obo:CL_4047054 obo:IAO_0000115 "A dendritic cell capable of capturing antigens in peripheral tissues and migrating through blood or lymphatic vessels to secondary lymphoid organs, where it presents processed antigens to T cells. It expresses MHC class II molecules and lacks lineage markers associated with other leukocyte populations, distinguishing it as a member of the dendritic cell lineage. This cell plays a pivotal role in initiating and regulating adaptive immune responses by linking peripheral antigen capture with T cell activation in lymphoid tissues." ; terms:contributor ; terms:date "2025-03-17T17:37:37Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "migratory dendtritic cell" ; rdfs:subClassOf obo:CL_0000451, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002407 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002468 ] . obo:CL_4047056 obo:IAO_0000115 "A columnar, mucin-producing cholangiocyte that lines large bile ducts, including the hilar bile duct, right and left hepatic bile ducts, and large intrahepatic bile ducts. This cell expresses phosphorylated STAT3 and TFF-3 in humans and mice." ; terms:contributor ; terms:date "2025-03-20T14:21:41Z"^^xsd:dateTime ; oboInOwl:hasNarrowSynonym "mucin-secreting cholangiocyte" ; a owl:Class ; rdfs:label "large mucus secreting cholangiocyte" ; rdfs:subClassOf obo:CL_0000319, obo:CL_1000488, obo:CL_1100001 . obo:CL_4047060 obo:IAO_0000115 "A circulating mononuclear phagocyte characterized by the expression of BCL-2-associated athanogene 3 (BAG3) protein, a co-chaperone involved in protein quality control and anti-apoptotic processes. (Fontanella, 2009). It undergoes cellular stress during the differentiation into M2 macrophages and is linked to poor survival rates in multiple cancer types. (Park, 2023)" ; terms:contributor ; terms:date "2025-05-06T14:41:24Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "BAG3+ monocyte" ; a owl:Class ; rdfs:label "BAG3-positive monocyte" ; rdfs:subClassOf obo:CL_0000576, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000004621 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000576 [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000004621 ] ) ] . obo:CL_4047101 obo:IAO_0000115 "A natural killer cell resident to the liver, located in the hepatic sinusoids. In humans this cell type is distinguished from circulating natural killer cells by CD49a or CD69 gene expression. Liver-resident natural killer cells have also been shown to express CCR5, EOMES, KLRB1, GZMK, and CXCR6 in humans." ; terms:contributor , "https://orcid.org/0000-0001-8134-3037" ; terms:date "2024-07-29T13:43:11Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "he-NK", "hepatic NK", "hepatic natural killer cells", "intrahepatic NK", "liver NK cell", "liver resident natural killer cell", "liver-specific natural killer cell", "lr-NK" ; a owl:Class ; rdfs:comment "Liver-resident natural killer cells play a crucial role in modulating the immune response during inflammation by balancing cytotoxic activity and cytokine production, thereby contributing to the maintenance of liver homeostasis and protection against excessive tissue damage." ; rdfs:label "liver-resident natural killer cell" ; rdfs:subClassOf obo:CL_0000623, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001281 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000623 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001281 ] ) ] . obo:CL_4052001 obo:IAO_0000115 "An ependymal cell that lines the lateral, third, and fourth ventricles of the brain. The cell is characterized by multiple motile cilia on its apical surface, which beats in a coordinated manner to facilitate the movement of cerebrospinal fluid (CSF), contributing to brain homeostasis." ; terms:contributor ; terms:date "2024-08-20T10:06:15Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "multiciliated ependymal cells" ; oboInOwl:hasRelatedSynonym "E1" ; a owl:Class ; rdfs:comment "multiciliated ependymal cell, with an average of 16 motile cilia per cell, exhibits two types of planar cell polarity (PCP): rotational polarity, with unidirectional cilia orientation, and translational polarity, with asymmetric cilia positioning in the apical area. This location-specific PCP varies across the ventricular wall, aligning with the direction of CSF flow. These cells are interconnected by adherens and gap junctions, which support intercellular communication and maintain the structural integrity of the ependymal layer. Unlike some other cell types, these cells lack tight junctions." ; rdfs:label "multiciliated ependymal cell" ; rdfs:subClassOf obo:CL_0000065, obo:CL_0005012 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004670 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0031514 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0010007 ] ) ] . obo:CL_4052002 obo:IAO_0000115 "A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm." ; terms:contributor ; terms:date "2024-08-15T10:38:46Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "syncytium" ; oboInOwl:hasRelatedSynonym "SC" ; a owl:Class ; rdfs:label "syncytial cell" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_0000228, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0000768 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0000768 ] ) ] ; skos:prefLabel "syncytial cell" . obo:CL_4052003 obo:IAO_0000115 "A capillary endothelial cell that is part of the intestinal villus. This cell is highly fenestrated, with fenestrations most numerous at the villus tips, and plays a vital role in nutrient absorption and maintaining the selective permeability of the intestinal barrier." ; terms:contributor ; terms:date "2024-09-17T10:03:25Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "villus blood capillary endothelial cells" ; oboInOwl:hasRelatedSynonym "villus tip endothelial cell" ; a owl:Class ; rdfs:label "intestinal villus capillary endothelial cell" ; rdfs:subClassOf obo:CL_0000131, obo:CL_0000666, obo:CL_0002144, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001213 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002144 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001213 ] ) ] . obo:CL_4052004 obo:IAO_0000115 "A specialized fibroblastic reticular cell that is part of gut-associated lymphoid tissue (GALT), responsible for forming a structural network that facilitates immune cell interactions. This cell is found in Peyer's patches, cryptopatches, and isolated lymphoid follicles. It plays crucial roles in maintaining intestinal immunity by controlling innate lymphoid cell homeostasis and function, organizing lymphoid structures, and contributing to intestinal microbiome balance." ; terms:contributor ; terms:date "2024-09-19T11:22:18Z"^^xsd:dateTime ; terms:description "Intestinal fibroblastic reticular cells develop from both perivascular and subepithelial progenitors during Peyer's patch formation. Intestinal fibroblastic reticular cells express key markers such as CCL19, CCL21, CXCL13, TNFSF13B (also known as BAFF), and produce IL-7, which are important for their immune regulatory functions and the organization of lymphoid structures." ; oboInOwl:hasNarrowSynonym "Ccl19-expressing fibroblastic reticular cell", "solitary intestinal lymphoid tissue fibroblastic reticular cell" ; oboInOwl:hasRelatedSynonym "gut-associated secondary lymphoid organs fibroblastic reticular cell" ; a owl:Class ; rdfs:label "intestinal fibroblastic reticular cell" ; rdfs:subClassOf obo:CL_0009101, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001962 ] . obo:CL_4052005 obo:IAO_0000115 "A fibroblast that is part of the subserosa of intestine. This cell interacts with immune cells and play roles in inflammation and fibrosis. In certain conditions, such as Crohn's disease, subserosal fibroblast may differentiate into myofibroblasts." ; terms:contributor ; terms:date "2024-09-19T12:58:29Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "intestinal subserosal fibroblast" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001243 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012375 ] . obo:CL_4052006 obo:IAO_0000115 "An epithelial cell that is part of the crypt of Lieberkuhn, originating from intestinal stem cells and giving rise to enteroendocrine cells (EECs). In mouse and human, this cell can be characterized by the expression of Neurog3, and has the ability to proliferate and differentiate into multiple EEC subtypes. Its proliferative potential contributes to crypt growth, distinguishing it from fully differentiated EECs." ; terms:contributor ; terms:date "2024-09-20T12:13:26Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "EEC Progenitor" ; a owl:Class ; rdfs:comment "The EEC progenitor is also present in other organisms; for example, flies have EEC progenitors but lack intestinal crypts and do not express the same markers. Instead, they are Dl+ and Pros+." ; rdfs:label "intestinal enteroendocrine progenitor" ; rdfs:subClassOf obo:CL_0002563, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011184 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002250 ] . obo:CL_4052007 obo:IAO_0000115 "A fibroblast located adjacent to the intestinal epithelium in both the small intestine and colon, specifically around the crypts. This cell is characterized by the expression of PDGFRα and various collagen isoforms, including COL4A5 and COL4A6. It secretes signalling molecules like TGF-β, Wnt ligands, and BMPs, which are crucial for epithelial homeostasis, intestinal stem cell support, and basement membrane formation." ; terms:contributor ; terms:date "2024-09-23T09:59:27Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "S2 fibroblast", "S2 mesenchymal cells" ; a owl:Class ; rdfs:comment "The S2 fibroblast population has been identified as a subset of intestinal fibroblasts located near the epithelial lining. This population is divided into two subtypes: S2a and S2b. S2a is involved in epithelial differentiation, while S2b, located at the top of the crypt, regulates intestinal stem cell proliferation, niche formation, and wound healing." ; rdfs:label "subepithelial intestinal fibroblast" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001277 ] . obo:CL_4052008 obo:IAO_0000115 "A subepithelial intestinal fibroblast that is located adjacent to the base of the crypt of Lieberkühn, near the intestinal stem cells. Characterized by low PDGFRα expression, this cell is crucial for maintaining the intestinal stem cell niche. Crypt-bottom fibroblast secretes key signaling molecules including canonical Wnt ligands (Wnt2, Wnt2b), Wnt potentiators (Rspo3), and BMP inhibitors (Grem1), which collectively regulate intestinal stem cell function and epithelial homeostasis." ; terms:contributor ; terms:date "2024-09-23T10:23:18Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "CBFs", "bottom pericryptic-associated fibroblasts" ; a owl:Class ; rdfs:label "crypt-bottom fibroblast" ; rdfs:subClassOf obo:CL_4052007, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:CL_0002250 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0013739 ] . obo:CL_4052009 obo:IAO_0000115 "A subepithelial intestinal fibroblast that is located adjacent to the top of the crypt of Lieberkuhn. Characterized by high experession of PDGFRα, this cell secretes a range of signaling factors, including WNTs and BMPs, that drive epithelial differentiation, creating a gradient that regulates the balance between stem cell maintenance and differentiation." ; terms:contributor ; terms:date "2024-09-23T11:14:04Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "CTFs", "S2b fibroblast", "top pericryptic fibroblast" ; a owl:Class ; rdfs:comment "S2b fibroblasts are located at the top of the crypt and express NRG1 and NPY." ; rdfs:label "crypt-top fibroblast" ; rdfs:subClassOf obo:CL_4052007, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0013740 ] . obo:CL_4052010 obo:IAO_0000115 "A stromal cell that serves as a precursor to the theca cell layers in the ovary growing follicles. This cell is present in the early stages of follicular growth, particularly in smaller follicles. Unlike mature theca cell, a pre-theca cell is initially non-steroidogenic and lacks luteinizing hormone receptors." ; terms:contributor ; terms:date "2024-09-25T11:15:57Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "early theca cell", "progenitor theca cell" ; a owl:Class ; rdfs:label "pre-theca cell" ; rdfs:subClassOf obo:CL_0002132, obo:CL_0002174, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012186 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000503 ] . obo:CL_4052011 obo:IAO_0000115 "An enterocyte found in the follicle-associated epithelium (FAE) that covers Peyer's patches and other mucosa-associated lymphoid tissues. This cell has reduced absorptive capacity and expresses higher levels of chemokines CCL20 and CXCL16, compared to regular villus enterocytes. It contributes to antigen sampling and immune interactions, supporting the specialized function of the FAE in mucosal immunity." ; terms:contributor ; terms:date "2024-09-25T15:28:25Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "follicle-associated epithelium enterocyte" ; oboInOwl:hasRelatedSynonym "FAE enterocyte", "follicular enterocyte" ; a owl:Class ; rdfs:label "follicle associated enterocyte" ; rdfs:subClassOf obo:CL_0000584, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004693 ] . obo:CL_4052012 obo:IAO_0000115 "A specialized theca cell that forms the inner, highly vascularized layer of the theca surrounding ovarian follicles. Originating from progenitor theca cells, the theca interna cell is steroidogenic, playing a crucial role in the production of androgens, which serves as a precursor for estrogen synthesis in granulosa cells. This cell expresses luteinizing hormone receptors, enabling it to respond to hormonal signals that regulate steroidogenesis." ; terms:contributor ; terms:date "2024-09-30T11:10:15Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "inTC", "interna TC" ; a owl:Class ; rdfs:label "interna theca cell" ; rdfs:subClassOf obo:CL_0000503, obo:CL_0000593, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000157 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_4052010 ] ; owl:disjointWith obo:CL_4052013 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000157 ] ) ] . obo:CL_4052013 obo:IAO_0000115 "A specialized theca cell that forms the outer layer of the theca surrounding the ovarian follicle, appearing at the antral follicle. Originating from progenitor theca cells, theca externa cell is characterized by its fibroblast-like appearance and primarily function to provide structural support to the developing follicle. This cell produces collagen fibers and extracellular matrix components such as Col1a1 and Col1a2." ; terms:contributor ; terms:date "2024-09-30T11:10:15Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "exTC", "externa TC" ; a owl:Class ; rdfs:label "externa theca cell" ; rdfs:subClassOf obo:CL_0000503, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000156 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_4052010 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000156 ] ) ] . obo:CL_4052014 obo:IAO_0000115 "A capillary endothelial cell that is part of islet of Langerhans, characterized by a high density of fenestrations —approximately ten times greater than those in exocrine pancreatic capillaries. These fenestrations facilitate efficient hormone exchange, which is essential for maintaining glucose homeostasis. The cell's structure and function are regulated by the local production of vascular endothelial growth factor-A (VEGF-A), which maintains its fenestrated architecture." ; terms:contributor ; terms:date "2024-09-30T14:36:12Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "islet endothelial cell", "pancreatic islet endothelial cell" ; a owl:Class ; rdfs:label "pancreatic islet capillary endothelial cell" ; rdfs:subClassOf obo:CL_0000666, obo:CL_0002144, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000006 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002144 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000006 ] ) ] . obo:CL_4052015 obo:IAO_0000115 "Any capillary endothelial cell that is part of an endocrine gland." ; terms:contributor ; terms:date "2024-09-30T15:27:49Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "endocrine gland capillary endothelial cell" ; rdfs:subClassOf obo:CL_0002144, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002368 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002144 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002368 ] ) ] . obo:CL_4052016 obo:IAO_0000115 "A capillary endothelial cell that is part of the pituitary gland. This cell is characterized by its fenestrated structure which facilitates the efficient transport of hormones and other signaling molecules, essential for endocrine signalling." ; terms:contributor ; terms:date "2024-09-30T15:31:45Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "In the anterior pituitary gland of rats, capillary endothelial cells are distinguished by numerous fenestrations, which are covered by a single-layered diaphragm. The diaphragm features a dense ring-like structure." ; rdfs:label "pituitary gland capillary endothelial cell" ; rdfs:subClassOf obo:CL_0000666, obo:CL_2000004, obo:CL_2000044, obo:CL_4052015 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002144 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000007 ] ) ] . obo:CL_4052017 obo:IAO_0000115 "A capillary endothelial cell that is part of the choroid plexus, characterized by its fenestrated nature with 60 to 80 nm fenestrations and lack of tight junctions. This fenestrated structure allows for the rapid delivery of water and other components, aiding in the production of cerebrospinal fluid (CSF)." ; terms:contributor ; terms:date "2024-10-01T11:38:22Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "choroid plexus capillary endothelial cell" ; rdfs:subClassOf obo:CL_0000666, obo:CL_0002144, obo:CL_2000044, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001886 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002144 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001886 ] ) ] . obo:CL_4052018 obo:IAO_0000115 "Any epithelial cell that is part of the fallopian tube." ; terms:contributor ; terms:date "2024-10-01T12:09:12Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "oviduct epithelial cell" ; oboInOwl:hasExactSynonym "uterine tube epithelial cell" ; a owl:Class ; rdfs:label "fallopian tube epithelial cell" ; rdfs:subClassOf obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003889 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003889 ] ) ] . obo:CL_4052019 obo:IAO_0000115 "Any epithelial cell that is part of the fallopian tube and lacks cilia." ; terms:contributor ; terms:date "2024-10-01T12:12:12Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "fallopian tube non-ciliated cell" ; a owl:Class ; rdfs:label "fallopian tube non-ciliated epithelial cell" ; rdfs:subClassOf obo:CL_4052018, [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0005929 ] . obo:CL_4052020 obo:IAO_0000115 "A granzyme K-associated CD8 T cell that resides in the lung, characterized by the expression of granzyme K (GZMK), and tissue residency markers CD103 and CD49a. This cell exhibits cytotoxic potential through its expression of multiple granzymes (GZMA, GZMB, GZMH, GZMM) in addition to GZMK." ; terms:contributor , ; terms:date "2024-10-14T15:42:41Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "lung resident CD8-GZMK" ; a owl:Class ; rdfs:comment "Lung resident granzyme K-associated CD8 T cell represents an intermediate stage of T cell differentiation, with GZMK expression peaking during this phase." ; rdfs:label "lung resident granzyme K-associated CD8 T cell" ; rdfs:subClassOf obo:CL_4033040, obo:CL_4052021 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4033040 [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000003472 ] ) ] . obo:CL_4052021 obo:IAO_0000115 "A CD8 T cell characterized by high expression of Granzyme K (GZMK). This cell is enriched in both inflamed tissues, such as synovial tissue in rheumatoid arthritis and respiratory tissues during COVID-19, as well as non-inflamed tissues like the gut and kidneys. Unlike highly cytotoxic GZMB+ CD8+ T cell, GZMK+ CD8+ T cell exhibits lower direct cytotoxic potential, and is involved in producing pro-inflammatory cytokines such as IFN-γ and TNF-α." ; terms:contributor ; terms:date "2024-10-18T09:51:48Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "granzyme K+ CD8 T cell", "tissue-enriched expressing GzmK CD8 cell" ; oboInOwl:hasNarrowSynonym "GZMK high CD8+ T effector memory cell" ; oboInOwl:hasRelatedSynonym "CD8-GZMK cell", "TteK CD8 cell" ; a owl:Class ; rdfs:label "granzyme K-associated CD8 T cell" ; rdfs:subClassOf obo:CL_0000909, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000003472 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000909 [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000003472 ] ) ] . obo:CL_4052022 obo:IAO_0000115 "A smooth muscle cell that is part of the fallopian tube. This cell is responsible for peristaltic contractions that facilitate gamete and embryo transport, fluid mixing, and embryo admission to the uterus." ; terms:contributor ; terms:date "2024-10-21T12:16:54Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "oviduct smooth muscle cell" ; oboInOwl:hasExactSynonym "uterine tube smooth muscle cell" ; a owl:Class ; rdfs:comment "The fallopian tube smooth muscle cell in the human contracts dynamically in response to hormones and signaling molecules. Prostaglandins, particularly PGF2α and PGE2, have been shown to increase muscular contractions, while progesterone, levonorgestrel, mifepristone, oxytocin, and human chorionic gonadotropin (hCG) decrease them. These contractile responses are crucial for regulating gamete and embryo transport through the fallopian tube." ; rdfs:label "fallopian tube smooth muscle cell" ; rdfs:subClassOf obo:CL_0000192, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003889 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003889 ] ) ] . obo:CL_4052023 obo:IAO_0000115 "An epithelial cell that is part of the endometrial luminal epithelium, forming a continuous layer lining the uterine cavity. This cell undergoes cyclical changes during the menstrual cycle, proliferating under estrogen in the proliferative phase, and differentiating under progesterone in the secretory phase to prepare for potential implantation. During the window of implantation, this cell changes from a tall columnar shape to a shorter columnar or cuboidal form, loses polarity, and becomes receptive to blastocyst implantation." ; terms:contributor ; terms:date "2024-10-22T12:02:23Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "The luminal endometrial unciliated epithelial cell expresses WNT7A, and LGR5 during the proliferative phase, transitioning to express VTCN1 and SULT1E1 in the early secretory phase, and LEFTY1, IL6, and PTGS1 in the mid- to late-secretory phases." ; rdfs:label "luminal endometrial unciliated epithelial cell" ; rdfs:subClassOf obo:CL_1001591, obo:CL_4052050 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011949 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032940 ] ) ] . obo:CL_4052024 obo:IAO_0000115 "A specialized muscle nucleus that is part of an extrafusal muscle fiber and overlaps the muscle-tendon junction, where muscle fibers connect to tendons. Characterized by a distinct transcriptional profile with the expression of genes like COL22A1, this myonucleus supports the structural integrity and function of the junction, playing a key role in transmitting the force generated by muscle contraction to the tendon." ; terms:contributor , ; terms:date "2024-10-30T13:47:39Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "myotendinous junction myonuclei", "myotendinous junction nuclei" ; oboInOwl:hasRelatedSynonym "MTJ nucleus" ; a owl:Class ; rdfs:label "myotendinous junction nucleus" ; rdfs:subClassOf obo:GO_0005634, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0008046 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:GO_0005927 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005634 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0008046 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:GO_0005927 ] ) ] . obo:CL_4052025 obo:IAO_0000115 "A specialized muscle nucleus that is part of an extrafusal muscle fiber, clustered at the postsynaptic side of the neuromuscular junction. This nucleus exhibits a distinct transcriptional profile, including acetylcholine receptor (AChR) subunit genes. It regulates the production of proteins essential for maintaining the structure and function of the neuromuscular junction, supporting efficient nerve-muscle signaling for muscle contraction." ; terms:contributor , ; terms:date "2024-10-31T11:09:04Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "neuromuscular junction myonuclei", "neuromuscular junction nuclei" ; oboInOwl:hasRelatedSynonym "NMJ nuclues" ; a owl:Class ; rdfs:label "neuromuscular junction nucleus" ; rdfs:subClassOf obo:GO_0005634, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0008046 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:GO_0098522 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005634 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0008046 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:GO_0098522 ] ) ] . obo:CL_4052026 obo:IAO_0000115 "A fast type II muscle cell that is part of the skeletal muscle tissue. This cell is characterized by its intermediate metabolic profile, utilizing both glycolytic and oxidative pathways for energy production. In humans, it is distinguished by the expression of myosin heavy chain 1 (MYH1)." ; terms:contributor ; terms:date "2024-11-04T10:26:29Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "type 2x fiber", "type 2x muscle cell", "type 2x muscle fiber", "type IIx muscle fiber" ; a owl:Class ; rdfs:comment "In humans, type IIx fiber contains high levels of MYLK2, enhancing contraction speed and force via myosin phosphorylation, especially under low calcium. This mechanism supports post-activation potentiation, increasing force output in fast-twitch muscles. Additionally, this fiber has abundant ACTN3 (α-actinin-3), linked to muscle power, and exhibits the highest shortening velocity among human muscle fiber types. Notably, type IIx fiber is selectively lost in aging-related sarcopenia, increases in proportion in type 2 diabetes and obesity, and is the first to degenerate in Duchenne Muscular Dystrophy, impacting muscle function across various conditions." ; rdfs:label "type IIx muscle cell" ; rdfs:subClassOf obo:CL_0002212 . obo:CL_4052027 obo:IAO_0000115 "A theca cell undergoing atresia, characterized by distinct morphological changes including hypertrophy, altered cell shape, and disrupted layered organization. This cell exhibits reduced steroidogenic capacity and changes in surrounding vascularization. The onset of theca cell atresia can vary, occurring at different stages of follicle atresia depending on the phase of folliculogenesis." ; terms:contributor ; terms:date "2024-11-06T10:10:51Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "During atresia, theca interna and externa cells undergo distinct morphological and functional changes. Theca interna cells round up, expand in cytoplasmic area, and thicken the internal layer as organization degrades, while showing reduced STAR expression, which lowers androgen production. Theca externa cells display decreased ACTA2 expression, weakening structural integrity." ; rdfs:label "atretic theca cell" ; rdfs:subClassOf obo:CL_4033089, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000503 ] . obo:CL_4052028 obo:IAO_0000115 "A natural killer cell that is part of the uterus, specifically within the endometrium during the non-pregnant state and in the decidua during pregnancy. This cell exhibits dynamic changes in frequency throughout the menstrual cycle, with lower levels during menstruation and a significant increase during the mid-secretory phase and early pregnancy." ; terms:contributor ; terms:date "2024-11-15T10:12:40Z"^^xsd:dateTime ; oboInOwl:hasNarrowSynonym "endometrial natural killer cell" ; oboInOwl:hasRelatedSynonym "uNK cell" ; a owl:Class ; rdfs:label "uterine natural killer cell" ; rdfs:subClassOf obo:CL_0000623, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000623 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ) ] . obo:CL_4052029 obo:IAO_0000115 "A fibroblast that is located beneath the visceral pleura of the lung. This cell contributes to the development of idiopathic pulmonary fibrosis (IPF) by forming fibrotic lesions that originate subpleurally and extend into lung tissue through activation, proliferation, migration, and differentiation into a myofibroblast." ; terms:contributor ; terms:date "2024-11-29T13:54:15Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "subpleural fibroblast" ; rdfs:subClassOf obo:CL_0002553 . obo:CL_4052030 obo:IAO_0000115 "A fibroblast of the adventitia of a blood vessel. This cell contributes to vascular homeostasis, remodeling, and inflammation by producing extracellular matrix components, cytokines, and growth factors. Adventitial fibroblast can transition into an activated state during injury or disease, marked by increased proliferation, migration, matrix deposition, and contractile protein expression" ; terms:contributor ; terms:date "2024-12-05T11:01:15Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Single-cell transcriptomics of murine aorta identifies two adventitial fibroblast-specific markers, PDGFRA and DPEP1, which were validated at the protein level by immunohistochemistry and flow cytometry across human and murine arteries, highlighting fibroblast heterogeneity in health and cardiovascular disease (CVD) in humans and mice." ; rdfs:label "adventitial fibroblast" ; rdfs:subClassOf obo:CL_0000057, obo:CL_0000151, obo:CL_0002503, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005734 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070278 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005734 ] ) ] . obo:CL_4052031 obo:IAO_0000115 "A secretory epithelial cell of the respiratory and terminal bronchioles." ; terms:contributor ; terms:date "2024-11-29T16:14:31Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "RAS cell", "terminal and respiratory bronchioles secretory cell" ; a owl:Class ; rdfs:comment "The respiratory airway secretory cell is cuboidal and has a unique transcriptomic profile compared to other epithelial cells in the same region. In humans, it functions as a multipotent progenitor, capable of regenerating alveolar type 2 (AT2) cells." ; rdfs:label "respiratory airway secretory cell" ; rdfs:subClassOf obo:CL_0000082, obo:CL_0002202, obo:CL_0008055, obo:CL_1000272, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002051 ] . obo:CL_4052032 obo:IAO_0000115 "A CD8 T cell characterized by high expression of Granzyme H (GZMH). This cell exhibits a restricted TCR repertoire and elevated expression of cytotoxic, exhaustion, and type I interferon-stimulated gene signatures compared to controls." ; terms:contributor , ; terms:date "2025-01-10T10:14:31Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "granzyme H+ CD8 T cell" ; oboInOwl:hasRelatedSynonym "GZMH+ CD8+ T cell" ; a owl:Class ; rdfs:comment "This cell type is significantly expanded in systemic lupus erythematosus (SLE) patients. Unlike other CD8 T cell populations, GZMH+ CD8 T cells can comprise up to 50% of all lymphocytes in some SLE patients." ; rdfs:label "granzyme H-associated CD8 T cell" ; rdfs:subClassOf obo:CL_0000909, [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000003490 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000909 [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000003490 ] ) ] . obo:CL_4052033 obo:IAO_0000115 "A tuft cell that is part of the extrahepatic biliary tree, including the gallbladder and extrahepatic bile ducts. It shares a core genetic program with intestinal tuft cells but has unique tissue-specific genes. Biliary tuft cell functions as a bile acid-sensitive regulator, suppressing inflammation and modulating microbiome-dependent neutrophil infiltration in biliary tissues. Unlike its intestinal counterparts, this cell decreases in number postnatally as bile acid production matures, with its abundance negatively regulated by bile acids." ; terms:contributor ; terms:date "2025-01-20T14:39:06Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "gallbladder/extrahepatic bile duct tuft cell" ; a owl:Class ; rdfs:label "biliary tuft cell" ; rdfs:subClassOf obo:CL_0002204, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050728 ] . obo:CL_4052034 obo:IAO_0000115 "A tuft cell that is part of the medullary epithelium of the thymus, characterized by lateral microvilli and specific markers, including L1CAM in both mice (Zhang et al., 2022) and humans (Sun et al., 2023), as well as MHC II in mice (Miller et al., 2018). This cell is pivotal in immune functions such as antigen presentation, central tolerance, and type 2 immunity. A tuft cell in the thymus exhibits characteristics of both a medullary thymic epithelial cell (mTEC) and a peripheral tuft cell. Its development is governed by transcription factors such as POU2F3." ; terms:contributor ; terms:date "2025-01-16T11:29:54Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "thymic tuft cell" ; a owl:Class ; rdfs:comment "A thymic tuft cell is a subset of terminally differentiated medullary thymic epithelial cell comprising 5-10% of total mTECs. Lineage-tracing studies indicate that this cell arises from mature MHCII mTECs, with development occurring through both Aire-dependent and Aire-independent pathways. However, its exact origins remain unclear." ; rdfs:label "tuft cell of thymus" ; rdfs:subClassOf obo:CL_0002204, obo:CL_0002365, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003846 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002491 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003846 ] ) ] . obo:CL_4052035 obo:IAO_0000115 "A tuft cell that is part of the epithelium of pancreatic duct. Present in humans and rats, this cell is absent in the murine pancreas under normal conditions but emerges during acinar-to-ductal metaplasia triggered by injury, inflammation, or oncogenic mutations. It modulates the immune response and protects against pancreatic ductal adenocarcinoma progression by producing suppressive eicosanoids, such as prostaglandin D2. A tuft cell in the pancreatic duct highly expresses the transcription factor POU2F3, which is essential for its development and presence." ; terms:contributor ; terms:date "2025-01-16T11:50:08Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "pancreatic brush cell", "pancreatic tuft cell" ; a owl:Class ; rdfs:label "tuft cell of pancreatic duct" ; rdfs:subClassOf obo:CL_0000068, obo:CL_0002204, obo:CL_1001433, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009970 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009970 ] ) ] . obo:CL_4052036 obo:IAO_0000115 "A tuft cell that is part of the nasal cavity epithelium, located in both the respiratory and olfactory epithelia of the nose. This cell plays key roles in chemosensation, lipid mediator production, immune responses, and epithelial homeostasis." ; terms:contributor ; terms:date "2025-01-21T09:04:03Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "nasal brush cell", "nasal tuft cell" ; a owl:Class ; rdfs:label "tuft cell of nasal cavity" ; rdfs:subClassOf obo:CL_0002204, obo:CL_0002631, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005384 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005384 ] ) ] . obo:CL_4052037 obo:IAO_0000115 "A tuft cell that is part of the olfactory epithelium, characterized by a globular body and the expression of neurogranin (Nrgn) in mice. This cell plays a crucial role in allergen recognition and regulating olfactory stem cell proliferation via TRPM5-dependent ATP sensing and cysteinyl leukotriene production. Unlike nasal respiratory tuft cells, it has low to absent expression of taste receptors, including the G protein Gα gustducin, and rarely contacts olfactory sensory neurons directly." ; terms:contributor ; terms:date "2025-02-06T15:03:53Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "olfactory tuft cell" ; oboInOwl:hasRelatedSynonym "TPRM5+ tuft-MVC", "TRPM5+ microvillous cell", "TRPM5+ microvillous tuft cell", "tuft-microvillous cell" ; a owl:Class ; rdfs:label "tuft cell of olfactory epithelium" ; rdfs:subClassOf obo:CL_0002167, obo:CL_4052036, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0072091 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001997 ] ) ] . obo:CL_4052038 obo:IAO_0000115 "A tuft cell that is part of the nasal cavity respiratory epithelium. Acting as a chemosensor, it detects bitter taste ligands and bacterial signals via taste receptors, maintaining epithelial-microbial homeostasis by stimulating antimicrobial peptide secretion from adjacent epithelial cells. This cell is a major source of IL-25, promoting type 2 immune responses and potentially contributing to chronic rhinosinusitis (O'Leary et al., 2019)." ; terms:contributor ; terms:date "2025-02-06T15:28:14Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "Gɑ-gustducin high respiratory tuft cell", "nasal respiratory solitary chemosensory cell", "tuft-solitary chemosensory cell" ; a owl:Class ; rdfs:label "tuft cell of nasal cavity respiratory epithelium" ; rdfs:subClassOf obo:CL_4052036, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005385 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005385 ] ) ] . obo:CL_4052039 obo:IAO_0000115 "A tuft cell that is part of the epithelium of the submandibular gland, localized to the striated ducts in mice, pigs, and humans, and to the main excretory ducts in rats. This cell is characterized by chemosensory functions, potential roles in immune regulation, and possible involvement in salivary secretion via acetylcholine release." ; terms:contributor ; terms:date "2025-02-12T10:38:11Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "tuft cell of submandibular gland" ; rdfs:subClassOf obo:CL_0002204, obo:CL_0002251, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003359 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003359 ] ) ] . obo:CL_4052040 obo:IAO_0000115 "A tuft cell that is part of the epithelium of the stomach. This cell is characterized by gastric chemosensation and immune regulation through IL-25 secretion, which activates ILC2s to produce IL-13, driving epithelial remodelling and tuft cell expansion. Unlike intestinal tuft cells, which are primarily involved in helminth defense and type 2 immunity, the tuft cell of the stomach is primarily involved in inflammation, metaplasia, and hyperplasia." ; terms:contributor ; terms:date "2025-02-12T11:24:56Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "gastric tuft cell" ; a owl:Class ; rdfs:label "tuft cell of stomach" ; rdfs:subClassOf obo:CL_0002178, obo:CL_0002204 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001276 ] ) ] . obo:CL_4052041 obo:IAO_0000115 "A tuft cell that is part of the epithelium of the pharyngotympanic (auditory) tube. This chemosensory cell is often positioned near cholinoreceptive sensory nerve fibers, suggesting a role in neuroimmune communication. It detects chemical signals and releases neuropeptides, such as acetylcholine (ACh) and CGRP, which contribute to inflammatory responses that help protect deeper tissues from harmful substances." ; terms:contributor ; terms:date "2025-02-12T12:00:10Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "tuft cell of auditory tube" ; rdfs:subClassOf obo:CL_0002204, obo:CL_0002491, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010062 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010062 ] ) ] . obo:CL_4052042 obo:IAO_0000115 "A tuft cell that is part of the epithelium of the urethra. This cell monitors urethral contents by detecting chemical stimuli, such as bitter compounds and sugars. Upon activation, it stimulates sensory nerve fibres and triggers detrusor muscle contraction, likely aiding in pathogen clearance by promoting bladder emptying." ; terms:contributor ; terms:date "2025-02-12T14:39:03Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "urethral brush cell", "urethral cholinergic chemosensory cell", "urethral tuft cell" ; a owl:Class ; rdfs:comment "Urethral tuft cells are heterogeneous, with both cholinergic and non-cholinergic populations present." ; rdfs:label "tuft cell of urethra" ; rdfs:subClassOf obo:CL_0002204, obo:CL_1000296, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002325 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_1904320 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002204 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002325 ] ) ] . obo:CL_4052045 obo:IAO_0000115 "A stromal cell that is part of the ovarian stroma, characterized by its ability to synthesize steroid hormones." ; terms:contributor ; terms:date "2025-03-05T13:37:44Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "steroidogenic interstitial stromal cell", "steroidogenic stromal cell" ; oboInOwl:hasRelatedSynonym "Enpp2− interstitial cell" ; a owl:Class ; rdfs:label "steroidogenic stromal cell of ovary" ; rdfs:subClassOf obo:CL_0002132, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006960 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0120178 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006960 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0120178 ] ) ] . obo:CL_4052046 obo:IAO_0000115 "A luteal cell that is part of the young, developing corpus luteum. This cell promotes progesterone synthesis, marked by high Parm1 expression in mice (Lan et al., 2024). An early luteal cell is associated with steroidogenesis and cell growth, contributing to early corpus luteum function and maturation." ; terms:contributor ; terms:date "2025-03-05T16:40:18Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "active corpus luteum cell" ; a owl:Class ; rdfs:label "early luteal cell" ; rdfs:subClassOf obo:CL_0000175, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006701 ] . obo:CL_4052047 obo:IAO_0000115 "A luteal cell that is part of the older, regressing corpus luteum. This cell exhibits increased expression of genes involved in progesterone metabolism - Akr1c18 in mice (Lan et al., 2024), cell cycle arrest, and apoptosis. A late luteal cell contributes to corpus luteum regression and eventual clearance from the ovary through luteolysis." ; terms:contributor ; terms:date "2025-03-05T16:47:20Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "regressing corpus luteum cell" ; a owl:Class ; rdfs:label "late luteal cell" ; rdfs:subClassOf obo:CL_0000175, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006709 ] . obo:CL_4052048 obo:IAO_0000115 "A cuboidal epithelial cell that is part of the intercalated duct of salivary gland. This cell expresses proteins commonly associated with acinar cells and displays calcium signaling characteristics similar to secretory cells, indicating an active role in the secretory process rather than ion reabsorption." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2024-09-11T09:55:55Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "intercalated duct cell" ; oboInOwl:hasExactSynonym "salivary intercalated duct cells" ; oboInOwl:hasRelatedSynonym "Id cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "intercalated cell of salivary gland" ; rdfs:subClassOf obo:CL_0000068, obo:CL_1001596, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014727 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0015766 ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/mouth-parotid-gland/v1.0/assets/2d-ftu-mouth-parotid-gland.png", "https://cdn.humanatlas.io/digital-objects/2d-ftu/mouth-sublingual-gland/v1.0/assets/2d-ftu-mouth-sublingual-gland.png", "https://cdn.humanatlas.io/digital-objects/2d-ftu/mouth-submandibular-gland/v1.0/assets/2d-ftu-mouth-submandibular-gland.png" . obo:CL_4052049 obo:IAO_0000115 "An columnar/cuboidal epithelial cell that is part of the striated duct of salivary gland, characterized by basal striations formed by infoldings of the plasma membrane. This cell play a crucial role in modifying the electrolyte composition and concentration of saliva through active ion transport, particularly the absorption of sodium and secretion of potassium." ; obo:RO_0002175 obo:NCBITaxon_9606 ; terms:contributor , ; terms:date "2024-09-11T10:00:25Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "SD cells", "striated duct cells" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "striated cell of salivary gland" ; rdfs:subClassOf obo:CL_0000068, obo:CL_0000075, obo:CL_1001596, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014729 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0015766 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0036376 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_1990573 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014729 ] ) ] ; foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/mouth-parotid-gland/v1.0/assets/2d-ftu-mouth-parotid-gland.png", "https://cdn.humanatlas.io/digital-objects/2d-ftu/mouth-submandibular-gland/v1.0/assets/2d-ftu-mouth-submandibular-gland.png" . obo:CL_4052050 obo:IAO_0000115 "An epithelial cell that is part of an endometrium luminal epithelium." ; terms:contributor ; terms:date "2025-03-13T13:46:13Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "endometrial luminal epithelial cell" ; a owl:Class ; rdfs:label "luminal epithelial cell of endometrium" ; rdfs:subClassOf obo:CL_0002149, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011949 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011949 ] ) ] . obo:CL_4052051 obo:IAO_0000115 "​​A uterine natural killer subset that is present in the endometrial lining during the non-pregnant state (Garcia-Alonso et al., 2021) and in the decidua during pregnancy (Vento-Tormo et al., 2018). It expresses the uterine resident marker CD49a and is distinguished from uNK2 and uNK3 by CD39 expression and the absence of CD103 (Whettlock et al., 2022) and CD160 (Marečková et al., 2024). It also expresses higher levels of killer-cell immunoglobulin-like receptors (KIRs) and leukocyte immunoglobulin-like receptor B1 (LILRB1), which facilitate interaction with human leukocyte antigens (HLAs) on extravillous trophoblast cells, promoting immune tolerance and implantation. Enriched in the endometrium post-ovulation (Marečková et al., 2024) and prominent in early pregnancy (Whettlock et al., 2022), uNK1 regulates trophoblast invasion and spiral artery remodeling (Zhang & Wei, 2021)." ; terms:contributor ; terms:date "2025-03-14T10:48:38Z"^^xsd:dateTime ; oboInOwl:hasNarrowSynonym "decidual natural killer cell 1" ; oboInOwl:hasRelatedSynonym "uNK1" ; a owl:Class ; rdfs:label "uterine natural killer cell 1, human" ; rdfs:subClassOf obo:CL_4052028, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_O95971 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_P38570 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P49961 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P56199 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4052028 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_O95971 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_P38570 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P49961 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P56199 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_4052052 obo:IAO_0000115 "A uterine natural killer subset that is present in the endometrial lining during the non-pregnant state (Garcia-Alonso et al., 2021) and in the decidua during pregnancy (Vento-Tormo et al., 2018), peaking in the first trimester. It expresses the uterine resident marker CD49a and is distinguished from uNK1 and uNK3 by the absence of CD39, CD103 (Whettlock et al., 2022), and CD160 (Marečková et al., 2024), with ITGB2 serving as a defining marker (Vento-Tormo et al., 2018). Functionally, it produces more cytokines upon stimulation than uNK1, suggesting a role in immune defense, and secretes XCL1 chemokines, facilitating interactions with maternal dendritic cells and fetal extravillous trophoblasts (Vento-Tormo et al., 2018)." ; terms:contributor ; terms:date "2025-03-14T14:31:03Z"^^xsd:dateTime ; oboInOwl:hasNarrowSynonym "decidual natural killer cell 2" ; oboInOwl:hasRelatedSynonym "uNK2" ; a owl:Class ; rdfs:label "uterine natural killer cell 2, human" ; rdfs:subClassOf obo:CL_4052028, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_O95971 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_P38570 ], [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_P49961 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P56199 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4052028 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_O95971 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_P38570 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_P49961 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P56199 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_4052053 obo:IAO_0000115 "A uterine natural killer subset found in the endometrial lining during the non-pregnant state (Garcia-Alonso et al., 2021) and in the decidua during pregnancy (Vento-Tormo et al., 2018), becoming the dominant uNK subset late in pregnancy. It expresses the uterine resident marker CD49a and is distinguished from uNK1 and uNK2 by CD160 (Marečková et al., 2024) and CD103 expression, the absence of CD39, and low KIR levels (Whettlock et al., 2022). Resembling intraepithelial ILC1 cells, uNK3 primarily supports uterine immune defense (Huhn et al., 2020) and indirectly influences trophoblast behavior through chemokine secretion, such as CCL5 (Vento-Tormo et al., 2018)." ; terms:contributor ; terms:date "2025-03-14T16:15:39Z"^^xsd:dateTime ; oboInOwl:hasNarrowSynonym "decidual natural killer cell 3" ; oboInOwl:hasRelatedSynonym "uNK3" ; a owl:Class ; rdfs:label "uterine natural killer cell 3, human" ; rdfs:subClassOf obo:CL_4052028, [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_P49961 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_O95971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P38570 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P56199 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4052028 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_P49961 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_O95971 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P38570 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P56199 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_4052055 obo:IAO_0000115 "A mature NK T cell that can be identified by the expression of CD56 in humans." ; terms:contributor , ; terms:date "2025-03-26T11:56:38Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "mature NK T lymphocyte, human", "mature NK T-cell, human", "mature NK T-lymphocyte, human", "mature NKT cell, human", "mature natural killer T cell, human", "mature natural killer T lymphocyte, human", "mature natural killer T-lymphocyte, human" ; a owl:Class ; rdfs:label "mature NK T cell, human" ; rdfs:subClassOf obo:CL_0000814, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P13591 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000814 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_P13591 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] . obo:CL_4052058 obo:IAO_0000115 "A Merkel cell found mainly in the basal layer of the epidermis and the outer root sheath of hair follicles, particularly concentrated in areas with high tactile acuity, such as touch domes, hair follicles, and fingertips." ; terms:contributor ; terms:date "2025-06-11T10:01:40Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "epdiermal Merkel cell" ; a owl:Class ; rdfs:label "Merkel cell of epidermis" ; rdfs:subClassOf obo:CL_0000242, obo:CL_0000362, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000242 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] ) ] . obo:CL_4052060 obo:IAO_0000115 "A differentiating keratinocyte found in the epidermis and oral epithelium, located in the stratum spinosum, characterized by a spiny appearance due to abundant intercellular desmosomal junctions." ; terms:contributor ; terms:date "2025-07-02T12:21:06Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "prickle cell" ; a owl:Class ; rdfs:label "spinous cell" ; rdfs:subClassOf obo:CL_0000312, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030057 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001365 ] . obo:CL_4052061 obo:IAO_0000115 "A keratinocyte of the skin epidermis that synthesizes keratin and undergoes successive stages of differentiation as it migrates from the basal layer to the cornified (stratum corneum) layer. These differentiation stages include the basal, spinous (prickle), and granular cell layers. This cell is central to epidermal homeostasis, mediating wound healing, immune modulation, including the secretion of cytokines and chemokines that recruit neutrophils (Simmons and Gallo, 2024), and intercellular communication with adjacent melanocytes (Marrapodi and Bellei, 2024)." ; terms:contributor ; terms:date "2025-07-02T12:32:13Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "keratincyte of epidermis", "skin keratinocyte" ; a owl:Class ; rdfs:comment "Keratinocytes are reportedly CDw210a(IL-10RA)-negative , CDw210b(IL-10RB)-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive." ; rdfs:label "epidermal keratinocyte" ; rdfs:subClassOf obo:CL_0000312, obo:CL_0000362, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0090023 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000312 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] ) ] . obo:CL_4052062 obo:IAO_0000115 "A specialized fibroblast located in the onychodermis that play a key role in nail growth and regeneration by interacting with LGR6-positive nail matrix keratinocytes. These interactions mediate essential signaling pathways, particularly WNT signaling, which is critical for epithelial–mesenchymal communication and coordinated nail development. In humans, this cell expresses key markers, including RSPO4, MSX1, WIF1, and BMP5, all involved in nail differentiation." ; terms:contributor ; terms:date "2025-07-22T14:35:00Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "onychofibroblast" ; rdfs:subClassOf obo:CL_0002620, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001705 ] . obo:CL_4070010 obo:IAO_0000115 "A motor neuron that moves the medial tooth forward" ; obo:RO_0002175 obo:NCBITaxon_6712, obo:NCBITaxon_6752 ; terms:contributor ; oboInOwl:hasExactSynonym "GM" ; a owl:Class ; rdfs:label "gastric mill neuron" ; rdfs:subClassOf obo:CL_0000100, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8910001 ] . obo:CL_4070011 obo:IAO_0000115 "A motor neuron that closes the lateral teeth." ; obo:RO_0002175 obo:NCBITaxon_6712, obo:NCBITaxon_6752 ; terms:contributor ; oboInOwl:hasExactSynonym "LG" ; a owl:Class ; rdfs:label "lateral gastric neuron" ; rdfs:subClassOf obo:CL_0000100, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8910001 ] . obo:CL_4070012 obo:IAO_0000115 "A motor neuron that controls ventral stomach grooves leading to pyloric filter." ; obo:RO_0002175 obo:NCBITaxon_6712, obo:NCBITaxon_6752 ; terms:contributor ; oboInOwl:hasExactSynonym "IC" ; a owl:Class ; rdfs:label "inferior cardiac neuron" ; rdfs:subClassOf obo:CL_0000100, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8910001 ] . obo:CL_4070013 obo:IAO_0000115 "A motor neuron that controls ventral stomach grooves leading to pyloric filter." ; obo:RO_0002175 obo:NCBITaxon_6712, obo:NCBITaxon_6752 ; terms:contributor ; oboInOwl:hasExactSynonym "VD" ; a owl:Class ; rdfs:label "ventricular dilator motor neuron" ; rdfs:subClassOf obo:CL_0000100, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8910001 ] . obo:CL_4070014 obo:IAO_0000115 "A motor neuron that controls pyloric filter movements; innervates the pyloric muscle." ; obo:RO_0002175 obo:NCBITaxon_6712, obo:NCBITaxon_6752 ; terms:contributor ; oboInOwl:hasExactSynonym "PY" ; a owl:Class ; rdfs:label "pyloric motor neuron" ; rdfs:subClassOf obo:CL_0000100, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8910001 ] . obo:CL_4070015 obo:IAO_0000115 "A motor neuron that controls the cardiopyloric valve." ; obo:RO_0002175 obo:NCBITaxon_6712, obo:NCBITaxon_6752 ; terms:contributor ; oboInOwl:hasExactSynonym "PD" ; a owl:Class ; rdfs:label "pyloric dilator neuron" ; rdfs:subClassOf obo:CL_0000100, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8910001 ] . obo:CL_4070016 obo:IAO_0000115 "Pyloric pacemaker neuron that provides feedback to commissural ganglia (CoG) neurons." ; obo:RO_0002175 obo:NCBITaxon_6712, obo:NCBITaxon_6752 ; terms:contributor ; oboInOwl:hasExactSynonym "AB" ; a owl:Class ; rdfs:label "anterior burster neuron" ; rdfs:subClassOf obo:CL_0000099, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8910001 ] . obo:CL_4070017 obo:IAO_0000115 "A motor neuron that controls pyloric filter movements; innervates the lateral pyloric muscle." ; obo:RO_0002175 obo:NCBITaxon_6712, obo:NCBITaxon_6752 ; terms:contributor ; oboInOwl:hasExactSynonym "LP" ; a owl:Class ; rdfs:label "lateral pyloric motor neuron" ; rdfs:subClassOf obo:CL_0000100, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_8910001 ] . obo:CL_4072001 obo:IAO_0000115 "A post-mitotic oligodendrocyte that has exited the cell cycle and begun early stage differentiation. The cell begins to acquire oligodendrocyte-like characteristics but has not yet initiated myelination. In mice, NFOL is marked by the expression of Tcf7l2 and Cemip2 (also known as Tmem2), among other early myelin-related genes. These markers highlight cells transitioning from a precursor to a more differentiated, pre-myelinating state." ; terms:contributor ; oboInOwl:hasRelatedSynonym "NFOL" ; a owl:Class ; rdfs:label "newly formed oligodendrocyte"@en ; rdfs:subClassOf obo:CL_0000123, obo:CL_0000128, [ a owl:Restriction ; owl:onProperty obo:RO_0002207 ; owl:someValuesFrom obo:CL_4023059 ] . obo:CL_4072002 obo:IAO_0000115 "A postmitotic and differentiated oligodendrocyte derived from a oligodendrocyte progenitor cell. A myelin-forming oligodendrocyte begins the expression of myelin genes and actively engages in the myelination process. In mice and humans, it is characterized by the upregulation of the key myelin-associated markers Mbp and Opalin. Additionally, Ctps (CTP synthase) shows peak expression at this stage, suggesting a heightened demand for nucleotide biosynthesis during membrane expansion and myelin production." ; terms:contributor ; oboInOwl:hasRelatedSynonym "MFOL" ; a owl:Class ; rdfs:label "myelin-forming oligodendrocyte"@en ; rdfs:subClassOf obo:CL_0000128, obo:UBERON_0004121, [ a owl:Restriction ; owl:onProperty obo:RO_0002207 ; owl:someValuesFrom obo:CL_4072001 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032289 ] . obo:CL_4072003 obo:IAO_0000115 "A post-mitotic oligodendrocyte derived from a myelin-forming oligodendrocyte (MFOL). A mature Myelinating Oligodendrocyte is a fully differentiated cell that is actively engaged in myelination. In addition to high expression of canonical myelin genes (e.g., Mbp, Plp1, Mog), a MOL can be distinguished by the expression of stage-enriched genes Grm3, Klk6, Ptgds, Anxa5, and Hopx in mice. These markers reflect the functional specialization of a mature oligodendrocyte, including roles in signalling, lipid metabolism, and myelin maintenance." ; terms:contributor ; oboInOwl:hasRelatedSynonym "MOL" ; a owl:Class ; rdfs:label "mature myelinating oligodendrocyte" ; rdfs:subClassOf obo:CL_0000128, obo:UBERON_0004121, [ a owl:Restriction ; owl:onProperty obo:RO_0002207 ; owl:someValuesFrom obo:CL_4072002 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032289 ] . obo:CL_4072005 obo:IAO_0000115 "A type of midbrain dopaminergic neuron localized in the retrorubral field which projects to limbic and cortical regions involved in emotion, motivation, and reward." ; terms:date "2025-05-02T08:37:36Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "A8 dopamine neuron" ; a owl:Class ; rdfs:label "A8 dopaminergic neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000097, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0011172 ] . obo:CL_4072006 obo:IAO_0000115 "A type of dopaminergic neuron in the substantia nigra involved in motor control and particularly vulnerable in Parkinson’s disease. In mice, it is notable for its heterogeneous co-release of dopamine with either glutamate or GABA. It releases GABA through alternative synthesis pathways or reuptake mechanisms independent of GAD expression." ; terms:date "2025-05-02T09:59:34Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "A9 nigral dopamine neuron", "substantia nigra dopaminergic neuron" ; a owl:Class ; rdfs:label "A9 dopaminergic neuron" ; rdfs:subClassOf obo:CL_0008060, obo:CL_4042025 . obo:CL_4072007 obo:IAO_0000115 "A type of dopaminergic neuron found in the ventral tegmental area that is involved in reward processes, motivation and addiction." ; terms:date "2025-05-02T10:13:27Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "A10 VTA Dopaminergic Neuron" ; a owl:Class ; rdfs:label "A10 dopaminergic neuron" ; rdfs:subClassOf obo:BFO_0000002, obo:CL_2000097, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002691 ] . obo:CL_4072008 obo:IAO_0000115 "A type of hypothalamic dopaminergic neuron found in the posterior hypothalamus, projecting to the spinal cord where it modulates pain, motor activity (Koblinger et al., 2014), and somatosensory processing (Zhang et a., 2023)." ; terms:date "2025-05-02T10:33:56Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "A11 dopaminergic neuron" ; rdfs:subClassOf obo:CL_0000700, obo:CL_0012001, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002770 ] . obo:CL_4072009 obo:IAO_0000115 "A type of dopaminergic neuron found in the arcuate hypothalamic nucleus, involved in neuroendocrine regulation, metabolic homeostasis and prolactin secretion." ; terms:date "2025-05-02T10:43:50Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "hypothalamic arcuate nucleus dopaminergic neuron" ; a owl:Class ; rdfs:label "A12 dopaminergic neuron" ; rdfs:subClassOf obo:CL_0000700, obo:CL_0012001, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001932 ] . obo:CL_4072010 obo:IAO_0000115 "A type of dopaminergic neuron located in the rostro-medial part of the zona incerta. It is involved in nociception and prehensile movement." ; terms:date "2025-05-02T14:46:33Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "A13 dopaminergic neuron" ; rdfs:subClassOf obo:CL_0000700, obo:CL_0012001, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0036007 ] . obo:CL_4072011 obo:IAO_0000115 "A type of dopaminergic neuron located in the periventricular nucleus of the hypothalamus and projecting to the lateral septum and the median eminence. It is contributing to neuroendocrine functions, locomotion and stress regulation." ; terms:date "2025-05-06T12:46:22Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "A14 dopaminergic neuron" ; rdfs:subClassOf obo:CL_0000700, obo:CL_2000029, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002322 ] . obo:CL_4072012 obo:IAO_0000115 "A type of dopaminergic neuron located in the preoptic periventricular nucleus of the hypothalamus and implicated in neuroendocrine modulation." ; terms:date "2025-05-06T13:00:54Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "A15 dopaminergic neuron" ; rdfs:subClassOf obo:CL_0000700, obo:CL_0012001, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002622 ] . obo:CL_4072013 obo:IAO_0000115 "A type of dopaminergic interneuron located in the glomerular layer of the main olfactory bulb, characterized by the co-release of dopamine and GABA, and involved in modulating sensory input within olfactory circuits." ; terms:date "2025-05-06T13:12:14Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "A16 dopaminergic neuron" ; rdfs:subClassOf obo:CL_0000700, obo:CL_0011005, obo:CL_1001434, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005377 ] . obo:CL_4072014 obo:IAO_0000115 "A specialized, non-ciliated ependymal glial cell located in the ventricular wall of the organum vasculosum of the lamina terminalis (OVLT) and characterized by elongated basal processes extending into the parenchyma to contact fenestrated capillaries. In mice, it is characterised by the expression of tight junction proteins (claudin 1, occludin, ZO-1) forming a continuous honeycomb junctional pattern. This cell contributes to a functional blood–cerebrospinal fluid (CSF) barrier at the ventricular interface of the OVLT." ; terms:date "2025-06-04T10:27:59Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "Tanycyte-like cells in CVOs" ; oboInOwl:hasExactSynonym "tanycyte-like cell of OVLT", "tanycyte-like ependymal cell of OVLT" ; a owl:Class ; rdfs:label "tanycyte of vascular organ of lamina terminalis" ; rdfs:subClassOf obo:CL_0002085, obo:CL_2000030, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002689 ] . obo:CL_4072015 obo:IAO_0000115 "A Kupffer cell located within the hepatic sinusoids, derived from circulating bone marrow monocytes that acquire the phenotypic markers and functional properties of resident Kupffer cells through niche-dependent imprinting, typically following depletion of the embryonically derived Kupffer cell population. During liver injury, MoKCs become the dominant Kupffer cell subset, exhibiting enhanced proliferation, resistance to apoptosis, and key roles in tissue repair and fibrosis attenuation." ; terms:date "2025-07-11T00:00:00Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "MoKC" ; a owl:Class ; rdfs:label "monocyte-derived Kupffer cell" ; rdfs:subClassOf obo:CL_0000091, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000860 ] . obo:CL_4072102 obo:IAO_0000115 "A type of GABAergic interneuron residing in the Purkinje cell layer of the cerebellar cortex." ; terms:date "2025-04-29T13:06:36Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "PLI" ; a owl:Class ; rdfs:label "Purkinje layer interneuron" ; rdfs:subClassOf obo:CL_4023057, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002979 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002979 ] ) ] . obo:CL_4300028 obo:CLM_0010003 obo:CLM_5007648 ; obo:IAO_0000028 "CB GABA (Mmus)" ; obo:IAO_0000115 "A cerebellar neuron of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:28 CB GABA." ; oboInOwl:hasExactSynonym "28 CB GABA" ; a owl:Class ; rdfs:label "cerebellar GABAergic neuron (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkZTMDBEWFYwVDlSMVg5Rko0UUUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_0000617, obo:CL_1001611, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4300029 obo:CLM_0010003 obo:CLM_5007649 ; obo:IAO_0000028 "CB Glut (Mmus)" ; obo:IAO_0000115 "A cerebellum glutamatergic neuron of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:29 CB Glut." ; oboInOwl:hasExactSynonym "29 CB Glut" ; a owl:Class ; rdfs:label "cerebellar glutamatergic neuron (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkZTMDBEWFYwVDlSMVg5Rko0UUUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_29.h5ad" ; rdfs:subClassOf obo:CL_2000028, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom ], [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4300031 obo:CLM_0010003 obo:CLM_5007651 ; obo:IAO_0000028 "OPC-Oligo (Mmus)" ; obo:IAO_0000115 "A cell of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:31 OPC-Oligo." ; oboInOwl:hasExactSynonym "31 OPC-Oligo" ; a owl:Class ; rdfs:label "OPC-Oligo cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIBMzEgT1BDLU9saWdvAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_0000255, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4300101 obo:CLM_0010003 obo:CLM_5000101, obo:CLM_5007721 ; obo:IAO_0000028 "STR D1 Gaba (Mmus)" ; obo:IAO_0000115 "A direct pathway medium spiny neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Prkch (Mmus), Slc32a1 (Mmus), Drd1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:061 STR D1 Gaba." ; oboInOwl:hasExactSynonym "061 STR D1 Gaba", "Prkch (Mmus), Slc32a1 (Mmus), Drd1 (Mmus) expressing direct pathway medium spiny neuron of brain (Mus musculus)" ; a owl:Class ; rdfs:label "STR D1 Gaba direct pathway medium spiny neuron (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMDYxIFNUUiBEMSBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_09.h5ad" ; rdfs:subClassOf obo:CL_4023026, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4300102 obo:CLM_0010003 obo:CLM_5000102, obo:CLM_5007722 ; obo:IAO_0000028 "STR D2 Gaba (Mmus)" ; obo:IAO_0000115 "A indirect pathway medium spiny neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Adora2a (Mmus), Phactr1 (Mmus), Pcp4l1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:062 STR D2 Gaba." ; oboInOwl:hasExactSynonym "062 STR D2 Gaba", "Adora2a (Mmus), Phactr1 (Mmus), Pcp4l1 (Mmus) expressing indirect pathway medium spiny neuron of brain (Mus musculus)" ; a owl:Class ; rdfs:label "STR D2 Gaba indirect pathway medium spiny neuron (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMDYyIFNUUiBEMiBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_09.h5ad" ; rdfs:subClassOf obo:CL_4023029, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4300348 obo:CLM_0010003 obo:CLM_5000348, obo:CLM_5007968 ; obo:IAO_0000028 "DCO Il22 Gly-Gaba (Mmus)" ; obo:IAO_0000115 "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Tmem204 (Mmus), Slc6a5 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:308 DCO Il22 Gly-Gaba." ; oboInOwl:hasExactSynonym "308 DCO Il22 Gly-Gaba", "Tmem204 (Mmus), Slc6a5 (Mmus) expressing cerebellar neuron of brain (Mus musculus)" ; a owl:Class ; rdfs:label "DCO Il22 Gly-Gaba cerebellar neuron (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzA4IERDTyBJbDIyIEdseS1HYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_0008059, obo:CL_4300028, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4300349 obo:CLM_0010003 obo:CLM_5000349, obo:CLM_5007969 ; obo:IAO_0000028 "CB PLI Gly-Gaba (Mmus)" ; obo:IAO_0000115 "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Rgs6 (Mmus), Slc6a5 (Mmus), Shisa9 (Mmus), Zic1 (Mmus), Bmp6 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:309 CB PLI Gly-Gaba." ; oboInOwl:hasExactSynonym "309 CB PLI Gly-Gaba", "Rgs6 (Mmus), Slc6a5 (Mmus), Shisa9 (Mmus), Zic1 (Mmus), Bmp6 (Mmus) expressing Purkinje layer interneuron of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Purkinje layer interneuron (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_4072102, obo:CL_4300028, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4300351 obo:CLM_0010003 obo:CLM_5000351, obo:CLM_5007971 ; obo:IAO_0000028 "CBX MLI Megf11 Gaba (Mmus)" ; obo:IAO_0000115 "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Homer3 (Mmus), Tfap2b (Mmus), Sorcs3 (Mmus), Cacna1e (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:311 CBX MLI Megf11 Gaba." ; oboInOwl:hasExactSynonym "311 CBX MLI Megf11 Gaba", "Homer3 (Mmus), Tfap2b (Mmus), Sorcs3 (Mmus), Cacna1e (Mmus) expressing molecular layer interneuron of brain (Mus musculus)" ; a owl:Class ; rdfs:label "CBX MLI Megf11 Gaba molecular layer interneuron (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzExIENCWCBNTEkgTWVnZjExIEdhYmEAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMxMSBDQlggTUxJIE1lZ2YxMSBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_4042035, obo:CL_4300028, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4300353 obo:CLM_0010003 obo:CLM_5000353, obo:CLM_5007973 ; obo:IAO_0000028 "CBX Purkinje Gaba (Mmus)" ; obo:IAO_0000115 "A Purkinje cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pcp2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:313 CBX Purkinje Gaba." ; oboInOwl:hasExactSynonym "313 CBX Purkinje Gaba", "Pcp2 (Mmus) expressing Purkinje cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Purkinje cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzEzIENCWCBQdXJraW5qZSBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgEzMTMgQ0JYIFB1cmtpbmplIEdhYmEAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_0000121, obo:CL_4300028, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4300354 obo:CLM_0010003 obo:CLM_5000354, obo:CLM_5007974 ; obo:IAO_0000028 "CB Granule Glut (Mmus)" ; obo:IAO_0000115 "A cerebellar granule cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Ror1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:314 CB Granule Glut." ; oboInOwl:hasExactSynonym "314 CB Granule Glut", "Gabra6 (Mmus), Ror1 (Mmus) expressing cerebellar granule cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "cerebellar granule cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_29.h5ad" ; rdfs:subClassOf obo:CL_0001031, obo:CL_4300029, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4300358 obo:CLM_0010003 obo:CLM_5000358, obo:CLM_5007978 ; obo:IAO_0000028 "Astro-NT NN (Mmus)" ; obo:IAO_0000115 "A transcriptomically defined type of astrocyte located predominantly in the ventral and posterior subcortical areas. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Cd38 (Mmus), Agt (Mmus), Itih3 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:318 Astro-NT NN." ; oboInOwl:hasExactSynonym "318 Astro-NT NN", "Aqp4 (Mmus), Cd38 (Mmus), Agt (Mmus), Itih3 (Mmus) expressing astrocyte of brain (Mus musculus)", "non-telencephalic astrocyte" ; a owl:Class ; rdfs:label "subcortical astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE4IEFzdHJvLU5UIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgEzMTggQXN0cm8tTlQgTk4AAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_0000127, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4300359 obo:CLM_0010003 obo:CLM_5000359, obo:CLM_5007979 ; obo:IAO_0000028 "Astro-TE NN (Mmus)" ; obo:IAO_0000115 "A transcritpomically defined type of astrocytes primarily restricted to the dorsal regions of the cerebrum. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Lhx2 (Mmus), Gpc5 (Mmus), Nr2f1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:319 Astro-TE NN." ; oboInOwl:hasExactSynonym "319 Astro-TE NN", "Gja1 (Mmus), Lhx2 (Mmus), Gpc5 (Mmus), Nr2f1 (Mmus) expressing astrocyte of brain (Mus musculus)", "telencephalic astrocyte" ; a owl:Class ; rdfs:label "astrocyte of cerebrum (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE5IEFzdHJvLVRFIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_0000127, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4300360 obo:CLM_0010003 obo:CLM_5000360, obo:CLM_5007980 ; obo:IAO_0000028 "Astro-OLF NN (Mmus)" ; obo:IAO_0000115 "A transcriptomically defined type of astrocyte located exclusively in the olfactory areas. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Hs3st3a1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:320 Astro-OLF NN." ; oboInOwl:hasExactSynonym "320 Astro-OLF NN", "Gja1 (Mmus), Hs3st3a1 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "olfactory areas astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_0000127, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4300362 obo:CLM_0010003 obo:CLM_5000362, obo:CLM_5007982 ; obo:IAO_0000028 "Tanycyte NN (Mmus)" ; obo:IAO_0000115 "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr50 (Mmus), Apoe (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:322 Tanycyte NN." ; oboInOwl:hasExactSynonym "322 Tanycyte NN", "Gpr50 (Mmus), Apoe (Mmus) expressing tanycyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "tanycyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzIyIFRhbnljeXRlIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_0002085, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4300363 obo:CLM_0010003 obo:CLM_5000363, obo:CLM_5007983 ; obo:IAO_0000028 "Ependymal NN (Mmus)" ; obo:IAO_0000115 "A ependymal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Tmem212 (Mmus), Rarres2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:323 Ependymal NN." ; oboInOwl:hasExactSynonym "323 Ependymal NN", "Tmem212 (Mmus), Rarres2 (Mmus) expressing ependymal cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "ependymal cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_0000065, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4300366 obo:CLM_0010003 obo:CLM_5000366, obo:CLM_5007986 ; obo:IAO_0000028 "OPC NN (Mmus)" ; obo:IAO_0000115 "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:326 OPC NN." ; oboInOwl:hasExactSynonym "326 OPC NN", "Pdgfra (Mmus) expressing oligodendrocyte precursor cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "oligodendrocyte precursor cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_0002453, obo:CL_4300031, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4300367 obo:CLM_0010003 obo:CLM_5000367, obo:CLM_5007987 ; obo:IAO_0000028 "Oligo NN (Mmus)" ; obo:IAO_0000115 "A oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), Gjc3 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:327 Oligo NN." ; oboInOwl:hasExactSynonym "327 Oligo NN", "Cldn11 (Mmus), Gjc3 (Mmus) expressing oligodendrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "oligodendrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzI3IE9saWdvIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_0000128, obo:CL_4300031, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4300370 obo:CLM_0010003 obo:CLM_5000370, obo:CLM_5007990 ; obo:IAO_0000028 "VLMC NN (Mmus)" ; obo:IAO_0000115 "A vascular leptomeningeal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Slc6a13 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:330 VLMC NN." ; oboInOwl:hasExactSynonym "330 VLMC NN", "Apod (Mmus), Slc6a13 (Mmus) expressing vascular leptomeningeal cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "VLMC NN vascular leptomeningeal cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzMwIFZMTUMgTk4AAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMzMCBWTE1DIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_33.h5ad" ; rdfs:subClassOf obo:CL_4023051, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301571 obo:CLM_0010003 obo:CLM_5001561, obo:CLM_5016781 ; obo:IAO_0000028 "DCO Il22 Gly-Gaba_1 (Mmus)" ; obo:IAO_0000115 "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Il22 (Mmus), Rftn1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1141 DCO Il22 Gly-Gaba_1." ; oboInOwl:hasExactSynonym "1141 DCO Il22 Gly-Gaba_1", "Il22 (Mmus), Rftn1 (Mmus) expressing cerebellar neuron of brain (Mus musculus)" ; a owl:Class ; rdfs:label "DCO Il22 Gly-Gaba_1 cerebellar neuron (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0MSBEQ08gSWwyMiBHbHktR2FiYV8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_4300348, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301573 obo:CLM_0010003 obo:CLM_5001563, obo:CLM_5016783 ; obo:IAO_0000028 "DCO Il22 Gly-Gaba_3 (Mmus)" ; obo:IAO_0000115 "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Fat2 (Mmus), Slc6a5 (Mmus), Cgnl1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1143 DCO Il22 Gly-Gaba_3." ; oboInOwl:hasExactSynonym "1143 DCO Il22 Gly-Gaba_3", "Fat2 (Mmus), Slc6a5 (Mmus), Cgnl1 (Mmus) expressing cerebellar neuron of brain (Mus musculus)" ; a owl:Class ; rdfs:label "DCO Il22 Gly-Gaba_3 cerebellar neuron (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0MyBEQ08gSWwyMiBHbHktR2FiYV8zAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_4300348, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301574 obo:CLM_0010003 obo:CLM_5001564, obo:CLM_5016784 ; obo:IAO_0000028 "CB PLI Gly-Gaba_1 (Mmus)" ; obo:IAO_0000115 "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Hmga2 (Mmus), Afap1l2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1144 CB PLI Gly-Gaba_1." ; oboInOwl:hasExactSynonym "1144 CB PLI Gly-Gaba_1", "Hmga2 (Mmus), Afap1l2 (Mmus) expressing Purkinje layer interneuron of brain (Mus musculus)" ; a owl:Class ; rdfs:label "CB PLI Gly-Gaba_1 Purkinje layer interneuron (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_4300349, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301575 obo:CLM_0010003 obo:CLM_5001565, obo:CLM_5016785 ; obo:IAO_0000028 "CB PLI Gly-Gaba_2 (Mmus)" ; obo:IAO_0000115 "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pthlh (Mmus), Tfap2b (Mmus), Rspo2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1145 CB PLI Gly-Gaba_2." ; oboInOwl:hasExactSynonym "1145 CB PLI Gly-Gaba_2", "Pthlh (Mmus), Tfap2b (Mmus), Rspo2 (Mmus) expressing Purkinje layer interneuron of brain (Mus musculus)" ; a owl:Class ; rdfs:label "CB PLI Gly-Gaba_2 Purkinje layer interneuron (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_0008059, obo:CL_4300349, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301576 obo:CLM_0010003 obo:CLM_5001566, obo:CLM_5016786 ; obo:IAO_0000028 "CB PLI Gly-Gaba_3 (Mmus)" ; obo:IAO_0000115 "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pax2 (Mmus), C1ql3 (Mmus), Tfap2b (Mmus), Gabrb1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1146 CB PLI Gly-Gaba_3." ; oboInOwl:hasExactSynonym "1146 CB PLI Gly-Gaba_3", "Pax2 (Mmus), C1ql3 (Mmus), Tfap2b (Mmus), Gabrb1 (Mmus) expressing Purkinje layer interneuron of brain (Mus musculus)" ; a owl:Class ; rdfs:label "CB PLI Gly-Gaba_3 Purkinje layer interneuron (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_4300349, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301578 obo:CLM_0010003 obo:CLM_5001568, obo:CLM_5007970, obo:CLM_5016788 ; obo:IAO_0000028 "CBX Golgi Gly-Gaba (Mmus)" ; obo:IAO_0000115 "A cerebellar Golgi cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Zfp385c (Mmus), Tfap2b (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1148 CBX Golgi Gly-Gaba_1." ; oboInOwl:hasExactSynonym "1148 CBX Golgi Gly-Gaba_1", "310 CBX Golgi Gly-Gaba", "Zfp385c (Mmus), Tfap2b (Mmus) expressing cerebellar Golgi cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "cerebellar Golgi cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_0000119, obo:CL_4300028, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301579 obo:CLM_0010003 obo:CLM_5001569, obo:CLM_5016789 ; obo:IAO_0000028 "CBX MLI Megf11 Gaba_1 (Mmus)" ; obo:IAO_0000115 "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dnah11 (Mmus), Sla (Mmus), Gldc (Mmus), Sdk2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1149 CBX MLI Megf11 Gaba_1." ; oboInOwl:hasExactSynonym "1149 CBX MLI Megf11 Gaba_1", "Dnah11 (Mmus), Sla (Mmus), Gldc (Mmus), Sdk2 (Mmus) expressing molecular layer interneuron of brain (Mus musculus)" ; a owl:Class ; rdfs:label "CBX MLI Megf11 Gaba_1 molecular layer interneuron (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0OSBDQlggTUxJIE1lZ2YxMSBHYWJhXzEAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExNDkgQ0JYIE1MSSBNZWdmMTEgR2FiYV8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_4300351, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301580 obo:CLM_0010003 obo:CLM_5001570, obo:CLM_5016790 ; obo:IAO_0000028 "CBX MLI Megf11 Gaba_2 (Mmus)" ; obo:IAO_0000115 "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Pvalb (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1150 CBX MLI Megf11 Gaba_2." ; oboInOwl:hasExactSynonym "1150 CBX MLI Megf11 Gaba_2", "Gabra6 (Mmus), Pvalb (Mmus) expressing molecular layer interneuron of brain (Mus musculus)" ; a owl:Class ; rdfs:label "CBX MLI Megf11 Gaba_2 molecular layer interneuron (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1MCBDQlggTUxJIE1lZ2YxMSBHYWJhXzIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExNTAgQ0JYIE1MSSBNZWdmMTEgR2FiYV8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_4300351, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301582 obo:CLM_0010003 obo:CLM_5001572, obo:CLM_5016792 ; obo:IAO_0000028 "CBX Purkinje Gaba_1 (Mmus)" ; obo:IAO_0000115 "A Purkinje cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pcp2 (Mmus), Stk17b (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1152 CBX Purkinje Gaba_1." ; oboInOwl:hasExactSynonym "1152 CBX Purkinje Gaba_1", "Pcp2 (Mmus), Stk17b (Mmus) expressing Purkinje cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "CBX Purkinje Gaba_1 Purkinje cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1MiBDQlggUHVya2luamUgR2FiYV8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_4300353, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301583 obo:CLM_0010003 obo:CLM_5016793 ; obo:IAO_0000028 "CBX Purkinje Gaba_2 (Mmus)" ; obo:IAO_0000115 "A Purkinje cell of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1153 CBX Purkinje Gaba_2." ; oboInOwl:hasExactSynonym "1153 CBX Purkinje Gaba_2" ; a owl:Class ; rdfs:label "CBX Purkinje Gaba_2 Purkinje cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1MyBDQlggUHVya2luamUgR2FiYV8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_4300353, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301584 obo:CLM_0010003 obo:CLM_5001574, obo:CLM_5016794 ; obo:IAO_0000028 "CB Granule Glut_1 (Mmus)" ; obo:IAO_0000115 "A cerebellar granule cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Lmx1a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1154 CB Granule Glut_1." ; oboInOwl:hasExactSynonym "1154 CB Granule Glut_1", "Gabra6 (Mmus), Lmx1a (Mmus) expressing cerebellar granule cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "CB Granule Glut_1 cerebellar granule cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_29.h5ad" ; rdfs:subClassOf obo:CL_4300354, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301585 obo:CLM_0010003 obo:CLM_5001575, obo:CLM_5016795 ; obo:IAO_0000028 "CB Granule Glut_2 (Mmus)" ; obo:IAO_0000115 "A cerebellar granule cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Gap43 (Mmus), Rab37 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1155 CB Granule Glut_2." ; oboInOwl:hasExactSynonym "1155 CB Granule Glut_2", "Gabra6 (Mmus), Gap43 (Mmus), Rab37 (Mmus) expressing cerebellar granule cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "CB Granule Glut_2 cerebellar granule cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_29.h5ad" ; rdfs:subClassOf obo:CL_4300354, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301586 obo:CLM_0010003 obo:CLM_5001576, obo:CLM_5007975, obo:CLM_5016796 ; obo:IAO_0000028 "DCO UBC Glut (Mmus)" ; obo:IAO_0000115 "A unipolar brush cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Sln (Mmus), Lmx1a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1156 DCO UBC Glut_1." ; oboInOwl:hasExactSynonym "1156 DCO UBC Glut_1", "315 DCO UBC Glut", "Sln (Mmus), Lmx1a (Mmus) expressing unipolar brush cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "unipolar brush cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_29.h5ad" ; rdfs:subClassOf obo:CL_4023161, obo:CL_4300029, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301589 obo:CLM_0010003 obo:CLM_5001579, obo:CLM_5016799 ; obo:IAO_0000028 "Astro-NT NN_1 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Lhfpl3 (Mmus), Gria1 (Mmus), Hopx (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1159 Astro-NT NN_1." ; oboInOwl:hasExactSynonym "1159 Astro-NT NN_1", "Gfap (Mmus), Lhfpl3 (Mmus), Gria1 (Mmus), Hopx (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-NT NN_1 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1OSBBc3Ryby1OVCBOTl8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4300358, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301590 obo:CLM_0010003 obo:CLM_5001580, obo:CLM_5016800 ; obo:IAO_0000028 "Astro-NT NN_2 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Itih3 (Mmus), Gria2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1160 Astro-NT NN_2." ; oboInOwl:hasExactSynonym "1160 Astro-NT NN_2", "Gja1 (Mmus), A330076C08Rik (Mmus), Itih3 (Mmus), Gria2 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-NT NN_2 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MCBBc3Ryby1OVCBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4300358, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301591 obo:CLM_0010003 obo:CLM_5001581, obo:CLM_5016801 ; obo:IAO_0000028 "Astro-TE NN_1 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Camk2a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1161 Astro-TE NN_1." ; oboInOwl:hasExactSynonym "1161 Astro-TE NN_1", "Myoc (Mmus), Camk2a (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-TE NN_1 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MSBBc3Ryby1URSBOTl8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4300359, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301592 obo:CLM_0010003 obo:CLM_5001582, obo:CLM_5016802 ; obo:IAO_0000028 "Astro-TE NN_2 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Hepacam (Mmus), E330013P04Rik (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1162 Astro-TE NN_2." ; oboInOwl:hasExactSynonym "1162 Astro-TE NN_2", "Hepacam (Mmus), E330013P04Rik (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-TE NN_2 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MiBBc3Ryby1URSBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4300359, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301593 obo:CLM_0010003 obo:CLM_5001583, obo:CLM_5016803 ; obo:IAO_0000028 "Astro-TE NN_3 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Grin2c (Mmus), Dcc (Mmus), Slc7a10 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1163 Astro-TE NN_3." ; oboInOwl:hasExactSynonym "1163 Astro-TE NN_3", "Gja1 (Mmus), Grin2c (Mmus), Dcc (Mmus), Slc7a10 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-TE NN_3 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MyBBc3Ryby1URSBOTl8zAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4300359, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301595 obo:CLM_0010003 obo:CLM_5001585, obo:CLM_5016805 ; obo:IAO_0000028 "Astro-TE NN_5 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Thbs4 (Mmus), Kcnk10 (Mmus), Pak1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1165 Astro-TE NN_5." ; oboInOwl:hasExactSynonym "1165 Astro-TE NN_5", "Gja1 (Mmus), Thbs4 (Mmus), Kcnk10 (Mmus), Pak1 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-TE NN_5 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2NSBBc3Ryby1URSBOTl81AAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4300359, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301596 obo:CLM_0010003 obo:CLM_5001586, obo:CLM_5016806 ; obo:IAO_0000028 "Astro-OLF NN_1 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Prss23 (Mmus), Igfbp2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1166 Astro-OLF NN_1." ; oboInOwl:hasExactSynonym "1166 Astro-OLF NN_1", "Aqp4 (Mmus), Prss23 (Mmus), Igfbp2 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-OLF NN_1 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4300360, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301597 obo:CLM_0010003 obo:CLM_5001587, obo:CLM_5016807 ; obo:IAO_0000028 "Astro-OLF NN_2 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Hs3st3a1 (Mmus), Slco1c1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1167 Astro-OLF NN_2." ; oboInOwl:hasExactSynonym "1167 Astro-OLF NN_2", "Gja1 (Mmus), Hs3st3a1 (Mmus), Slco1c1 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-OLF NN_2 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4300360, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301598 obo:CLM_0010003 obo:CLM_5001588, obo:CLM_5016808 ; obo:IAO_0000028 "Astro-OLF NN_3 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ednrb (Mmus), Hs3st3a1 (Mmus), C230072F16Rik (Mmus), Gria2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1168 Astro-OLF NN_3." ; oboInOwl:hasExactSynonym "1168 Astro-OLF NN_3", "Ednrb (Mmus), Hs3st3a1 (Mmus), C230072F16Rik (Mmus), Gria2 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-OLF NN_3 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4300360, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301602 obo:CLM_0010003 obo:CLM_5001592, obo:CLM_5016812 ; obo:IAO_0000028 "Tanycyte NN_1 (Mmus)" ; obo:IAO_0000115 "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cnmd (Mmus), Lpl (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1172 Tanycyte NN_1." ; oboInOwl:hasExactSynonym "1172 Tanycyte NN_1", "Cnmd (Mmus), Lpl (Mmus) expressing tanycyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Tanycyte NN_1 tanycyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE3MiBUYW55Y3l0ZSBOTl8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4300362, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301603 obo:CLM_0010003 obo:CLM_5001593, obo:CLM_5016813 ; obo:IAO_0000028 "Tanycyte NN_2 (Mmus)" ; obo:IAO_0000115 "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr50 (Mmus), Ccdc170 (Mmus), Nkx2-4 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1173 Tanycyte NN_2." ; oboInOwl:hasExactSynonym "1173 Tanycyte NN_2", "Gpr50 (Mmus), Ccdc170 (Mmus), Nkx2-4 (Mmus) expressing tanycyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Tanycyte NN_2 tanycyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE3MyBUYW55Y3l0ZSBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4300362, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301608 obo:CLM_0010003 obo:CLM_5001598, obo:CLM_5007985, obo:CLM_5016818 ; obo:IAO_0000028 "CHOR NN (Mmus)" ; obo:IAO_0000115 "A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1178 CHOR NN_1." ; oboInOwl:hasExactSynonym "1178 CHOR NN_1", "2900040C04Rik (Mmus) expressing choroid plexus epithelial cell of brain (Mus musculus)", "325 CHOR NN" ; a owl:Class ; rdfs:label "choroid plexus epithelial cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzI1IENIT1IgTk4AAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMyNSBDSE9SIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_0000706, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301611 obo:CLM_0010003 obo:CLM_5001601, obo:CLM_5016821, obo:CLM_5024421 ; obo:IAO_0000028 "COP NN_1 (Mmus)" ; obo:IAO_0000115 "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bmp4 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1181 COP NN_1." ; oboInOwl:hasExactSynonym "1181 COP NN_1", "Gpr17 (Mmus), Bmp4 (Mmus) expressing committed oligodendrocyte precursor of brain (Mus musculus)" ; a owl:Class ; rdfs:label "commited oligodendrocyte precursor (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4023059, obo:CL_4300367, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301612 obo:CLM_0010003 obo:CLM_5001602, obo:CLM_5016822, obo:CLM_5024422 ; obo:IAO_0000028 "NFOL NN_2 (Mmus)" ; obo:IAO_0000115 "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Ptprb (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1182 NFOL NN_2." ; oboInOwl:hasExactSynonym "1182 NFOL NN_2", "9630013A20Rik (Mmus), Ptprb (Mmus) expressing newly formed oligodendrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "newly formed oligodendrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE4MiBORk9MIE5OXzIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExODIgTkZPTCBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4072001, obo:CL_4300367, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301613 obo:CLM_0010003 obo:CLM_5001603, obo:CLM_5016823, obo:CLM_5024423 ; obo:IAO_0000028 "MFOL NN_3 (Mmus)" ; obo:IAO_0000115 "A myelin-forming oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), Sec14l5 (Mmus), 9630013A20Rik (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1183 MFOL NN_3." ; oboInOwl:hasExactSynonym "1183 MFOL NN_3", "Cldn11 (Mmus), Sec14l5 (Mmus), 9630013A20Rik (Mmus) expressing myelin-forming oligodendrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "myelin-forming oligodendrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE4MyBNRk9MIE5OXzMAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExODMgTUZPTCBOTl8zAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4072002, obo:CL_4300367, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301614 obo:CLM_0010003 obo:CLM_5001604, obo:CLM_5016824, obo:CLM_5024424 ; obo:IAO_0000028 "MOL NN_4 (Mmus)" ; obo:IAO_0000115 "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), Anln (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1184 MOL NN_4." ; oboInOwl:hasExactSynonym "1184 MOL NN_4", "Cldn11 (Mmus), Anln (Mmus) expressing mature myelinating oligodendrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "mature myelinating oligodendrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4072003, obo:CL_4300367, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301615 obo:CLM_0010003 obo:CLM_5001605, obo:CLM_5007652, obo:CLM_5007988, obo:CLM_5016825 ; obo:IAO_0000028 "OEC (Mmus)" ; obo:IAO_0000115 "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Npy (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1185 OEC NN_1." ; oboInOwl:hasExactSynonym "1185 OEC NN_1", "32 OEC", "328 OEC NN", "Apod (Mmus), Npy (Mmus) expressing olfactory ensheathing cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "olfactory ensheathing cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIBMzIgT0VDAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECRlMwMERYVjBUOVIxWDlGSjRRRQADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgEzMiBPRUMAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQJGUzAwRFhWMFQ5UjFYOUZKNFFFAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_32.h5ad" ; rdfs:subClassOf obo:CL_0011028, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301616 obo:CLM_0010003 obo:CLM_5001606, obo:CLM_5007989, obo:CLM_5016826 ; obo:IAO_0000028 "ABC NN (Mmus)" ; obo:IAO_0000115 "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Thbd (Mmus), Ccn3 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1186 ABC NN_1." ; oboInOwl:hasExactSynonym "1186 ABC NN_1", "329 ABC NN", "Thbd (Mmus), Ccn3 (Mmus) expressing arachnoid barrier cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "arachnoid barrier cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_33.h5ad" ; rdfs:subClassOf obo:CL_4023097, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4301625 obo:CLM_0010003 obo:CLM_5001615, obo:CLM_5007995, obo:CLM_5016835 ; obo:IAO_0000028 "BAM NN (Mmus)" ; obo:IAO_0000115 "A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Maf (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1195 BAM NN_1." ; oboInOwl:hasExactSynonym "1195 BAM NN_1", "335 BAM NN", "Mrc1 (Mmus), Maf (Mmus) expressing border associated macrophage of brain (Mus musculus)" ; a owl:Class ; rdfs:label "border associated macrophage (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_34.h5ad" ; rdfs:subClassOf obo:CL_4042003, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4304384 obo:CLM_0010001 , , , , , , ; obo:CLM_0010003 obo:CLM_5004314, obo:CLM_5007635, obo:CLM_5007802, obo:CLM_5019534 ; obo:IAO_0000028 "HY Gnrh1 Glut (Mmus)" ; obo:IAO_0000115 "A hypothalamic gonadotropin-releasing hormone neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gnrh1 (Mmus). It is glutamatergic. These cells are located in the Hypothalamus, Olfactory areas, Pallidum, brain , in or close to the regions: Lateral septal nucleus, rostral (rostroventral) part, Medial septal nucleus, Diagonal band nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:2564 HY Gnrh1 Glut_1." ; oboInOwl:hasExactSynonym "0628 HY Gnrh1 Glut_1", "142 HY Gnrh1 Glut", "15 HY Gnrh1 Glut", "2564 HY Gnrh1 Glut_1", "Gnrh1 (Mmus) expressing hypothalamic gonadotropin-releasing hormone neuron of brain (Mus musculus)" ; a owl:Class ; rdfs:label "hypothalamic gonadotropin-releasing hormone neuron (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkZTMDBEWFYwVDlSMVg5Rko0UUUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_15.h5ad" ; rdfs:subClassOf obo:CL_0000679, obo:CL_0011111, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4306426 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5006356, obo:CLM_5007645, obo:CLM_5007922, obo:CLM_5021576, obo:CLM_5029176 ; obo:IAO_0000028 "pinealocyte (Mmus)" ; obo:IAO_0000115 "A pinealocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cngb3 (Mmus), Ush2a (Mmus). It is glutamatergic. These cells are located in the brain , in or close to the regions: third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:4606 Pineal Crx Glut_1." ; oboInOwl:hasExactSynonym "1030 Pineal Crx Glut_1", "25 Pineal Glut", "262 Pineal Crx Glut", "4606 Pineal Crx Glut_1", "Cngb3 (Mmus), Ush2a (Mmus) expressing pinealocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "pinealocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIBMjUgUGluZWFsIEdsdXQAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJGUzAwRFhWMFQ5UjFYOUZKNFFFAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACATI1IFBpbmVhbCBHbHV0AAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECRlMwMERYVjBUOVIxWDlGSjRRRQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_25.h5ad" ; rdfs:subClassOf obo:CL_0000652, _:genid17936, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4306992 obo:CLM_0010001 , , , , , ; obo:CLM_0010003 obo:CLM_5006922, obo:CLM_5022142 ; obo:IAO_0000028 "DCO Il22 Gly-Gaba_2 (Mmus)" ; obo:IAO_0000115 "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Il22 (Mmus), Edaradd (Mmus). It is distinguished from other DCO Il22 Gly-Gaba cells by expression of Ppp1r17. It is GABAergic and glycinergic. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Paraflocculus, arbor vitae, Dorsal cochlear nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5172 DCO Il22 Gly-Gaba_2." ; oboInOwl:hasExactSynonym "1142 DCO Il22 Gly-Gaba_2", "5172 DCO Il22 Gly-Gaba_2", "Il22 (Mmus), Edaradd (Mmus) expressing cerebellar neuron of brain (Mus musculus)" ; a owl:Class ; rdfs:label "DCO Il22 Gly-Gaba_2 cerebellar neuron (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTE3MiBEQ08gSWwyMiBHbHktR2FiYV8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_4300348, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307005 obo:CLM_0010001 , , , , ; obo:CLM_0010003 obo:CLM_5006935, obo:CLM_5022155 ; obo:IAO_0000028 "CB PLI Gly-Gaba_4 (Mmus)" ; obo:IAO_0000115 "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ly6d (Mmus), Kit (Mmus). It is distinguished from other CB PLI Gly-Gaba cells by expression of Ly6d. It is GABAergic. These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae, Interposed nucleus, Nodulus (X) . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5185 CB PLI Gly-Gaba_4." ; oboInOwl:hasExactSynonym "1147 CB PLI Gly-Gaba_4", "5185 CB PLI Gly-Gaba_4", "Ly6d (Mmus), Kit (Mmus) expressing Purkinje layer interneuron of brain (Mus musculus)" ; a owl:Class ; rdfs:comment "Warning: Despite its name, CB PLI Gly-Gaba_4 does not secrete the neurotransmitter Gly, as assessed by expression of multiple marker genes." ; rdfs:label "CB PLI GABA Ly6d Purkinje layer interneuron" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTE4NSBDQiBQTEkgR2x5LUdhYmFfNAAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTE4NSBDQiBQTEkgR2x5LUdhYmFfNAAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_4300349, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307012 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5006942, obo:CLM_5007972, obo:CLM_5022162 ; obo:IAO_0000028 "CBX MLI Cdh22 Gaba (Mmus)" ; obo:IAO_0000115 "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cdh1 (Mmus), Acvr1c (Mmus), Adamts15 (Mmus), Pax2 (Mmus). It is distinguished from other CB GABA cells by expression of Cdh1, Acvr1c, Adamts15, Pax2. It is GABAergic. These cells are located in the Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5192 CBX MLI Cdh22 Gaba_1." ; oboInOwl:hasExactSynonym "1151 CBX MLI Cdh22 Gaba_1", "312 CBX MLI Cdh22 Gaba", "5192 CBX MLI Cdh22 Gaba_1", "Cdh1 (Mmus), Acvr1c (Mmus), Adamts15 (Mmus), Pax2 (Mmus) expressing molecular layer interneuron of brain (Mus musculus)" ; a owl:Class ; rdfs:label "CBX MLI Cdh22 Gaba molecular layer interneuron (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" ; rdfs:subClassOf obo:CL_4042035, obo:CL_4300028, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307026 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5006956, obo:CLM_5007976, obo:CLM_5022176 ; obo:IAO_0000028 "Bergman glial cell (Mmus)" ; obo:IAO_0000115 "A Bergmann glial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr37l1 (Mmus), Ctxn3 (Mmus). It is distinguished from other Astro-Epen cells by expression of Gpr37l1, Ctxn3. These cells are located in the Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5206 Bergmann NN_1." ; oboInOwl:hasExactSynonym "1157 Bergmann NN_1", "316 Bergmann NN", "5206 Bergmann NN_1", "Gpr37l1 (Mmus), Ctxn3 (Mmus) expressing Bergmann glial cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Bergman glial cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIwNiBCZXJnbWFubiBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_0000644, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307027 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5006957, obo:CLM_5007977, obo:CLM_5022177 ; obo:IAO_0000028 "cerebellar astrocyte (Mmus)" ; obo:IAO_0000115 "A transcriptomically defined type of astrocyte localized exclusively in the cerebellum beneath the Purkinje cell layer. It is distinguished from other cells in the brain by selective expression of Dao (Mmus), Efemp1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5207 Astro-CB NN_1." ; oboInOwl:hasExactSynonym "1158 Astro-CB NN_1", "317 Astro-CB NN", "5207 Astro-CB NN_1", "Dao (Mmus), Efemp1 (Mmus) expressing astrocyte of the cerebellum of brain (Mus musculus)" ; a owl:Class ; rdfs:label "cerebellar astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIwNyBBc3Ryby1DQiBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_0002603, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307028 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5006958, obo:CLM_5022178 ; obo:IAO_0000028 "Astro-NT NN_1 Galnt15 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Galnt15 (Mmus), Agt (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Galnt15. These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5208 Astro-NT NN_1." ; oboInOwl:hasExactSynonym "5208 Astro-NT NN_1", "Gfap (Mmus), Galnt15 (Mmus), Agt (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-NT NN_1 Galnt15 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIwOCBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301589, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307029 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5006959, obo:CLM_5022179 ; obo:IAO_0000028 "Astro-NT NN_1 Slc36a2 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Slc36a2 (Mmus), Sfrp5 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Slc36a2, Sfrp5. These cells are located in the Midbrain, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5209 Astro-NT NN_1." ; oboInOwl:hasExactSynonym "5209 Astro-NT NN_1", "Gfap (Mmus), Slc36a2 (Mmus), Sfrp5 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-NT NN_1 Slc36a2 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIwOSBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301589, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307030 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5006960, obo:CLM_5022180 ; obo:IAO_0000028 "Astro-NT NN_1 Nuf2 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Sfrp5 (Mmus), Cldn10 (Mmus), Riiad1 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Nuf2, Shroom3. These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5210 Astro-NT NN_1." ; oboInOwl:hasExactSynonym "5210 Astro-NT NN_1", "Gfap (Mmus), Sfrp5 (Mmus), Cldn10 (Mmus), Riiad1 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-NT NN_1 Nuf2 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxMCBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301589, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307031 obo:CLM_0010001 , , , ; obo:CLM_0010003 obo:CLM_5006961, obo:CLM_5022181 ; obo:IAO_0000028 "Astro-NT NN_1 Six3os1 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Six3os1 (Mmus), Slc36a2 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Six3os1. These cells are located in the Striatum-like amygdalar nuclei, Olfactory areas, brain , in or close to the regions: Medial amygdalar nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5211 Astro-NT NN_1." ; oboInOwl:hasExactSynonym "5211 Astro-NT NN_1", "Myoc (Mmus), Six3os1 (Mmus), Slc36a2 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-NT NN_1 Six3os1 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxMSBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301589, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307032 obo:CLM_0010001 , , , ; obo:CLM_0010003 obo:CLM_5006962, obo:CLM_5022182 ; obo:IAO_0000028 "Astro-NT NN_1 Kcnk10 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Agt (Mmus), Prss35 (Mmus), C4b (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Kcnk10, C4b. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5212 Astro-NT NN_1." ; oboInOwl:hasExactSynonym "5212 Astro-NT NN_1", "Agt (Mmus), Prss35 (Mmus), C4b (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-NT NN_1 Kcnk10 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxMiBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301589, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307033 obo:CLM_0010001 , , , , , , ; obo:CLM_0010003 obo:CLM_5006963, obo:CLM_5022183 ; obo:IAO_0000028 "Astro-NT NN_1 Mecom (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dao (Mmus), Mecom (Mmus), Fbln5 (Mmus), Prelp (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Mecom, Prelp. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Ventral cochlear nucleus, Paraflocculus, Flocculus, Dorsal cochlear nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5213 Astro-NT NN_1." ; oboInOwl:hasExactSynonym "5213 Astro-NT NN_1", "Dao (Mmus), Mecom (Mmus), Fbln5 (Mmus), Prelp (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-NT NN_1 Mecom astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxMyBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301589, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307034 obo:CLM_0010001 , , , ; obo:CLM_0010003 obo:CLM_5006964, obo:CLM_5022184 ; obo:IAO_0000028 "Astro-NT NN_2 Fzd2 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Sfrp5 (Mmus), Gria2 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Fzd2, Gria2, Ttll3. These cells are located in the Midbrain, Thalamus, Pons , in or close to the regions: Midbrain reticular nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5214 Astro-NT NN_2." ; oboInOwl:hasExactSynonym "5214 Astro-NT NN_2", "Gja1 (Mmus), A330076C08Rik (Mmus), Sfrp5 (Mmus), Gria2 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-NT NN_2 Fzd2 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNCBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301590, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307035 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5006965, obo:CLM_5022185 ; obo:IAO_0000028 "Astro-NT NN_2 Sez6l (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Otx2 (Mmus), Unc13c (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Sez6l, Unc13c. These cells are located in the Thalamus , in or close to the regions: Posterior complex of the thalamus, Ventral posteromedial nucleus of the thalamus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5215 Astro-NT NN_2." ; oboInOwl:hasExactSynonym "5215 Astro-NT NN_2", "Gja1 (Mmus), A330076C08Rik (Mmus), Otx2 (Mmus), Unc13c (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-NT NN_2 Sez6l astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNSBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301590, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307036 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5006966, obo:CLM_5022186 ; obo:IAO_0000028 "Astro-NT NN_2 Fam227b (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc7a10 (Mmus), Cyp26b1 (Mmus), Igfbp2 (Mmus), Shroom3 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Fam227b, Shroom3. These cells are located in the Midbrain, Medulla, Pons . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5216 Astro-NT NN_2." ; oboInOwl:hasExactSynonym "5216 Astro-NT NN_2", "Slc7a10 (Mmus), Cyp26b1 (Mmus), Igfbp2 (Mmus), Shroom3 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-NT NN_2 Fam227b astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNiBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301590, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307037 obo:CLM_0010001 , , , , ; obo:CLM_0010003 obo:CLM_5006967, obo:CLM_5022187 ; obo:IAO_0000028 "Astro-NT NN_2 Gm30524 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), A330076C08Rik (Mmus), Fbln5 (Mmus), Mdga2 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Gm30524. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Ventral cochlear nucleus, arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5217 Astro-NT NN_2." ; oboInOwl:hasExactSynonym "5217 Astro-NT NN_2", "Aqp4 (Mmus), A330076C08Rik (Mmus), Fbln5 (Mmus), Mdga2 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-NT NN_2 Gm30524 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNyBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301590, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307038 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5006968, obo:CLM_5022188 ; obo:IAO_0000028 "Astro-TE NN_1 Myoc (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Lhx2 (Mmus), Kcne1l (Mmus), Alpk1 (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Kcne1l, Alpk1. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5218 Astro-TE NN_1." ; oboInOwl:hasExactSynonym "5218 Astro-TE NN_1", "Myoc (Mmus), Lhx2 (Mmus), Kcne1l (Mmus), Alpk1 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-TE NN_1 Myoc astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxOCBBc3Ryby1URSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301591, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307039 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5006969, obo:CLM_5022189 ; obo:IAO_0000028 "Astro-TE NN_1 Rasl10b (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Ddn (Mmus), Myoc (Mmus), Rasl10b (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Rasl10b, Igfbp5. These cells are located in the Hippocampal region, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5219 Astro-TE NN_1." ; oboInOwl:hasExactSynonym "5219 Astro-TE NN_1", "Gfap (Mmus), Ddn (Mmus), Myoc (Mmus), Rasl10b (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-TE NN_1 Rasl10b astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxOSBBc3Ryby1URSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301591, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307040 obo:CLM_0010001 ; obo:CLM_0010003 obo:CLM_5006970, obo:CLM_5022190 ; obo:IAO_0000028 "Astro-TE NN_1 Lncpint (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Dio2 (Mmus), Lncpint (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Lncpint. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5220 Astro-TE NN_1." ; oboInOwl:hasExactSynonym "5220 Astro-TE NN_1", "Myoc (Mmus), Dio2 (Mmus), Lncpint (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-TE NN_1 Lncpint astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyMCBBc3Ryby1URSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301591, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307041 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5006971, obo:CLM_5022191 ; obo:IAO_0000028 "Astro-TE NN_1 Jph4 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Sptbn2 (Mmus), Alpk1 (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Jph4, Alpk1. It is glutamatergic. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5221 Astro-TE NN_1." ; oboInOwl:hasExactSynonym "5221 Astro-TE NN_1", "Myoc (Mmus), Sptbn2 (Mmus), Alpk1 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-TE NN_1 Jph4 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyMSBBc3Ryby1URSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_0000151, obo:CL_4301591, _:genid18197, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307042 obo:CLM_0010001 , , , , ; obo:CLM_0010003 obo:CLM_5006972, obo:CLM_5022192 ; obo:IAO_0000028 "Astro-TE NN_2 Clstn2 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gm6145 (Mmus), E330013P04Rik (Mmus), Slc39a12 (Mmus). It is distinguished from other Astro-TE NN_2 cells by expression of Clstn2. These cells are located in the Hippocampal region , in or close to the regions: Dentate gyrus, molecular layer, Dentate gyrus, polymorph layer, Field CA3, stratum oriens, Dentate gyrus, granule cell layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5222 Astro-TE NN_2." ; oboInOwl:hasExactSynonym "5222 Astro-TE NN_2", "Gm6145 (Mmus), E330013P04Rik (Mmus), Slc39a12 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-TE NN_2 Clstn2 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyMiBBc3Ryby1URSBOTl8yAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgE1MjIyIEFzdHJvLVRFIE5OXzIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301592, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307043 obo:CLM_0010001 , , , ; obo:CLM_0010003 obo:CLM_5006973, obo:CLM_5022193 ; obo:IAO_0000028 "Astro-TE NN_2 Mcm6 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mcm6 (Mmus), Egfr (Mmus), Pcsk6 (Mmus). It is distinguished from other Astro-TE NN_2 cells by expression of Mcm6. These cells are located in the Hippocampal region , in or close to the regions: Dentate gyrus, molecular layer, Dentate gyrus, polymorph layer, Dentate gyrus, granule cell layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5223 Astro-TE NN_2." ; oboInOwl:hasExactSynonym "5223 Astro-TE NN_2", "Mcm6 (Mmus), Egfr (Mmus), Pcsk6 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-TE NN_2 Mcm6 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyMyBBc3Ryby1URSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301592, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307044 obo:CLM_0010001 , , , ; obo:CLM_0010003 obo:CLM_5006974, obo:CLM_5022194 ; obo:IAO_0000028 "Astro-TE NN_3 Cxcl5 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Cxcl5 (Mmus), Ddn (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Cxcl5, Kif5a. These cells are located in the Hippocampal region, Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5224 Astro-TE NN_3." ; oboInOwl:hasExactSynonym "5224 Astro-TE NN_3", "Gja1 (Mmus), Cxcl5 (Mmus), Ddn (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-TE NN_3 Cxcl5 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNCBBc3Ryby1URSBOTl8zAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301593, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307045 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5006975, obo:CLM_5022195 ; obo:IAO_0000028 "Astro-TE NN_3 Fam163a (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Fam163a (Mmus), Kcnq3 (Mmus), Kcnq1ot1 (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Fam163a, Nr2f1, Kcnq1ot1. These cells are located in the Isocortex, Olfactory areas . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5225 Astro-TE NN_3." ; oboInOwl:hasExactSynonym "5225 Astro-TE NN_3", "S1pr1 (Mmus), Fam163a (Mmus), Kcnq3 (Mmus), Kcnq1ot1 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-TE NN_3 Fam163a astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNSBBc3Ryby1URSBOTl8zAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301593, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307046 obo:CLM_0010001 , , , ; obo:CLM_0010003 obo:CLM_5006976, obo:CLM_5022196 ; obo:IAO_0000028 "Astro-TE NN_3 Zic4 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Ranbp3l (Mmus), Emx2os (Mmus), Zic4 (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Zic4. These cells are located in the Lateral septal complex, Isocortex, Olfactory areas , in or close to the regions: Lateral septal nucleus, rostral (rostroventral) part . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5226 Astro-TE NN_3." ; oboInOwl:hasExactSynonym "5226 Astro-TE NN_3", "S1pr1 (Mmus), Ranbp3l (Mmus), Emx2os (Mmus), Zic4 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-TE NN_3 Zic4 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNiBBc3Ryby1URSBOTl8zAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301593, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307047 obo:CLM_0010001 , , , ; obo:CLM_0010003 obo:CLM_5006977, obo:CLM_5022197 ; obo:IAO_0000028 "Astro-TE NN_3 Crym (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Crym (Mmus), Grin2c (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Crym, Gabbr2. These cells are located in the Striatum dorsal region, Striatum ventral region , in or close to the regions: Nucleus accumbens, Caudoputamen . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5227 Astro-TE NN_3." ; oboInOwl:hasExactSynonym "5227 Astro-TE NN_3", "S1pr1 (Mmus), Crym (Mmus), Grin2c (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-TE NN_3 Crym astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNyBBc3Ryby1URSBOTl8zAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301593, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307048 obo:CLM_0010001 , , , ; obo:CLM_0010003 obo:CLM_5006978, obo:CLM_5022198 ; obo:IAO_0000028 "Astro-TE NN_4 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Thbs4 (Mmus), Gm29683 (Mmus), Slc39a12 (Mmus). It is distinguished from other Astro-TE NN cells by expression of Gm29683. These cells are located in the Cortical subplate, brain , in or close to the regions: Lateral amygdalar nucleus, external capsule . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5228 Astro-TE NN_4." ; oboInOwl:hasExactSynonym "1164 Astro-TE NN_4", "5228 Astro-TE NN_4", "S1pr1 (Mmus), Thbs4 (Mmus), Gm29683 (Mmus), Slc39a12 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-TE NN_4 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyOCBBc3Ryby1URSBOTl80AAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4300359, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307049 obo:CLM_0010001 , , , , , ; obo:CLM_0010003 obo:CLM_5006979, obo:CLM_5022199 ; obo:IAO_0000028 "Astro-TE NN_5 Hs3st3a1 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Thbs4 (Mmus), Hs3st3a1 (Mmus), Sfrp1 (Mmus). It is distinguished from other Astro-TE NN_5 cells by expression of Hs3st3a1, Sfrp1. These cells are located in the Olfactory areas, brain , in or close to the regions: Anterior olfactory nucleus, corpus callosum, body, lateral ventricle, corpus callosum, anterior forceps . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5229 Astro-TE NN_5." ; oboInOwl:hasExactSynonym "5229 Astro-TE NN_5", "S1pr1 (Mmus), Thbs4 (Mmus), Hs3st3a1 (Mmus), Sfrp1 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-TE NN_5 Hs3st3a1 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyOSBBc3Ryby1URSBOTl81AAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301595, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307050 obo:CLM_0010001 , , , , , ; obo:CLM_0010003 obo:CLM_5006980, obo:CLM_5022200 ; obo:IAO_0000028 "Astro-TE NN_5 Adamts18 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Adamts18 (Mmus), Crym (Mmus). It is distinguished from other Astro-TE NN_5 cells by expression of Adamts18. These cells are located in the Lateral septal complex, Striatum dorsal region, brain , in or close to the regions: Nucleus accumbens, Caudoputamen, lateral ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5230 Astro-TE NN_5." ; oboInOwl:hasExactSynonym "5230 Astro-TE NN_5", "S1pr1 (Mmus), Adamts18 (Mmus), Crym (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-TE NN_5 Adamts18 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIzMCBBc3Ryby1URSBOTl81AAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301595, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307051 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5006981, obo:CLM_5022201 ; obo:IAO_0000028 "Astro-OLF NN_1 Greb1 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Chrdl1 (Mmus), Ano1 (Mmus), Il33 (Mmus). It is distinguished from other Astro-OLF NN_1 cells by expression of Greb1, Il33. These cells are located in the Olfactory areas, brain , in or close to the regions: Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5231 Astro-OLF NN_1." ; oboInOwl:hasExactSynonym "5231 Astro-OLF NN_1", "Gja1 (Mmus), Chrdl1 (Mmus), Ano1 (Mmus), Il33 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-OLF NN_1 Greb1 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIzMSBBc3Ryby1PTEYgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIzMSBBc3Ryby1PTEYgTk5fMQAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301596, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307052 obo:CLM_0010001 , , , ; obo:CLM_0010003 obo:CLM_5006982, obo:CLM_5022202 ; obo:IAO_0000028 "Astro-OLF NN_1 Stk32a (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Prss23 (Mmus), Stk32a (Mmus). It is distinguished from other Astro-OLF NN_1 cells by expression of Stk32a. These cells are located in the Olfactory areas, brain , in or close to the regions: olfactory nerve layer of main olfactory bulb, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5232 Astro-OLF NN_1." ; oboInOwl:hasExactSynonym "5232 Astro-OLF NN_1", "Aqp4 (Mmus), Prss23 (Mmus), Stk32a (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-OLF NN_1 Stk32a astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIzMiBBc3Ryby1PTEYgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIzMiBBc3Ryby1PTEYgTk5fMQAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301596, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307053 obo:CLM_0010001 , , , ; obo:CLM_0010003 obo:CLM_5006983, obo:CLM_5022203 ; obo:IAO_0000028 "Astro-OLF NN_2 Slc25a34 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Hs3st3a1 (Mmus), Slc25a34 (Mmus), C4b (Mmus). It is distinguished from other Astro-OLF NN_2 cells by expression of Slc25a34, C4b. These cells are located in the Olfactory areas, brain , in or close to the regions: Main olfactory bulb, outer plexiform layer, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5233 Astro-OLF NN_2." ; oboInOwl:hasExactSynonym "5233 Astro-OLF NN_2", "Aqp4 (Mmus), Hs3st3a1 (Mmus), Slc25a34 (Mmus), C4b (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-OLF NN_2 Slc25a34 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301597, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307054 obo:CLM_0010001 , , , ; obo:CLM_0010003 obo:CLM_5006984, obo:CLM_5022204 ; obo:IAO_0000028 "Astro-OLF NN_2 Alk (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Chrdl1 (Mmus), Sfrp1 (Mmus), Atp13a4 (Mmus). It is distinguished from other Astro-OLF NN_2 cells by expression of Alk, Atp13a4. These cells are located in the Olfactory areas , in or close to the regions: Anterior olfactory nucleus, Main olfactory bulb, granule layer, Main olfactory bulb, mitral layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5234 Astro-OLF NN_2." ; oboInOwl:hasExactSynonym "5234 Astro-OLF NN_2", "S1pr1 (Mmus), Chrdl1 (Mmus), Sfrp1 (Mmus), Atp13a4 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-OLF NN_2 Alk astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301597, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307055 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5006985, obo:CLM_5022205 ; obo:IAO_0000028 "Astro-OLF NN_3 Ecrg4 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C230072F16Rik (Mmus), Dipk1c (Mmus), Ecrg4 (Mmus). It is distinguished from other Astro-OLF NN_3 cells by expression of Ecrg4. These cells are located in the Olfactory areas , in or close to the regions: Main olfactory bulb, granule layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5235 Astro-OLF NN_3." ; oboInOwl:hasExactSynonym "5235 Astro-OLF NN_3", "C230072F16Rik (Mmus), Dipk1c (Mmus), Ecrg4 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-OLF NN_3 Ecrg4 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301598, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307056 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5006986, obo:CLM_5022206 ; obo:IAO_0000028 "Astro-OLF NN_3 Sfrp1 (Mmus)" ; obo:IAO_0000115 "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), 6530411M01Rik (Mmus), Sfrp1 (Mmus), Aqp4 (Mmus). It is distinguished from other Astro-OLF NN_3 cells by expression of Sfrp1, Aqp4. These cells are located in the Olfactory areas , in or close to the regions: Main olfactory bulb, granule layer, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5236 Astro-OLF NN_3." ; oboInOwl:hasExactSynonym "5236 Astro-OLF NN_3", "S1pr1 (Mmus), 6530411M01Rik (Mmus), Sfrp1 (Mmus), Aqp4 (Mmus) expressing astrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Astro-OLF NN_3 Sfrp1 astrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301598, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307063 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5006993, obo:CLM_5022213 ; obo:IAO_0000028 "Tanycyte NN_1 Cnmd (Mmus)" ; obo:IAO_0000115 "A tanycyte of subfornical organ of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cnmd (Mmus), Sfta3-ps (Mmus). It is distinguished from other Tanycyte NN_1 cells by expression of Cnmd. These cells are located in the brain , in or close to the regions: choroid plexus, third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5243 Tanycyte NN_1." ; oboInOwl:hasExactSynonym "5243 Tanycyte NN_1", "Cnmd (Mmus), Sfta3-ps (Mmus) expressing tanycyte of subfornical organ of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Tanycyte NN_1 Cnmd tanycyte of subfornical organ (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0MyBUYW55Y3l0ZSBOTl8xAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgE1MjQzIFRhbnljeXRlIE5OXzEAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_0008042, obo:CL_4301602, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307064 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5006994, obo:CLM_5022214 ; obo:IAO_0000028 "Tanycyte NN_1 Glp1r (Mmus)" ; obo:IAO_0000115 "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C230072F16Rik (Mmus), Glp1r (Mmus). It is distinguished from other Tanycyte NN_1 cells by expression of Glp1r. These cells are located in the Hypothalamus, brain , in or close to the regions: Anteroventral periventricular nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5244 Tanycyte NN_1." ; oboInOwl:hasExactSynonym "5244 Tanycyte NN_1", "C230072F16Rik (Mmus), Glp1r (Mmus) expressing tanycyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Tanycyte NN_1 Glp1r tanycyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0NCBUYW55Y3l0ZSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301602, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307065 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5006995, obo:CLM_5022215 ; obo:IAO_0000028 "Tanycyte NN_2 Mylk3 (Mmus)" ; obo:IAO_0000115 "A alpha1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dynlrb2 (Mmus), Mylk3 (Mmus), Sfta3-ps (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Mylk3. It is glutamatergic. These cells are located in the Hypothalamus , in or close to the regions: Periventricular hypothalamic nucleus, intermediate part . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5245 Tanycyte NN_2." ; oboInOwl:hasExactSynonym "5245 Tanycyte NN_2", "Dynlrb2 (Mmus), Mylk3 (Mmus), Sfta3-ps (Mmus) expressing alpha1-tanycyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Tanycyte NN_2 Mylk3 alpha1-tanycyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0NSBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgE1MjQ1IFRhbnljeXRlIE5OXzIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_1100001, obo:CL_4042017, obo:CL_4301603, _:genid18447, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307066 obo:CLM_0010001 , , , , ; obo:CLM_0010003 obo:CLM_5006996, obo:CLM_5022216 ; obo:IAO_0000028 "Tanycyte NN_2 Mroh5 (Mmus)" ; obo:IAO_0000115 "A alpha1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ccdc170 (Mmus), Nkx2-4 (Mmus), Dock8 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Mroh5. These cells are located in the Hypothalamus, brain , in or close to the regions: Periventricular hypothalamic nucleus, intermediate part, third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5246 Tanycyte NN_2." ; oboInOwl:hasExactSynonym "5246 Tanycyte NN_2", "Ccdc170 (Mmus), Nkx2-4 (Mmus), Dock8 (Mmus) expressing alpha1-tanycyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Tanycyte NN_2 Mroh5 alpha1-tanycyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0NiBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4042017, obo:CL_4301603, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307067 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5006997, obo:CLM_5022217 ; obo:IAO_0000028 "Tanycyte NN_2 Dscaml1 (Mmus)" ; obo:IAO_0000115 "A alpha2-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdzph1 (Mmus), Wdr63 (Mmus), Dscaml1 (Mmus), P3h2 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Dscaml1, P3h2. These cells are located in the Hypothalamus , in or close to the regions: Periventricular hypothalamic nucleus, posterior part, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5247 Tanycyte NN_2." ; oboInOwl:hasExactSynonym "5247 Tanycyte NN_2", "Pdzph1 (Mmus), Wdr63 (Mmus), Dscaml1 (Mmus), P3h2 (Mmus) expressing alpha2-tanycyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "alpha2-tanycyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0NyBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4042018, obo:CL_4301603, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307068 obo:CLM_0010001 , , , ; obo:CLM_0010003 obo:CLM_5006998, obo:CLM_5022218 ; obo:IAO_0000028 "Tanycyte NN_2 Otx2 (Mmus)" ; obo:IAO_0000115 "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ccdc146 (Mmus), Tbx3 (Mmus), Otx2 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Otx2, Nkx2-4. These cells are located in the Hypothalamus, brain , in or close to the regions: Periventricular hypothalamic nucleus, posterior part, third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5248 Tanycyte NN_2." ; oboInOwl:hasExactSynonym "5248 Tanycyte NN_2", "Ccdc146 (Mmus), Tbx3 (Mmus), Otx2 (Mmus) expressing tanycyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "Tanycyte NN_2 Otx2 tanycyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0OCBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301603, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307069 obo:CLM_0010001 , , , ; obo:CLM_0010003 obo:CLM_5006999, obo:CLM_5022219 ; obo:IAO_0000028 "Tanycyte NN_2 Col25a1 (Mmus)" ; obo:IAO_0000115 "A beta1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr50 (Mmus), Frzb (Mmus), Foxd2os (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Col25a1, C230072F16Rik. These cells are located in the Hypothalamus, brain , in or close to the regions: third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5249 Tanycyte NN_2." ; oboInOwl:hasExactSynonym "5249 Tanycyte NN_2", "Gpr50 (Mmus), Frzb (Mmus), Foxd2os (Mmus) expressing beta1-tanycyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "beta1-tancyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0OSBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4042019, obo:CL_4301603, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307070 obo:CLM_0010001 , , , , ; obo:CLM_0010003 obo:CLM_5007000, obo:CLM_5022220 ; obo:IAO_0000028 "Tanycyte NN_3 (Mmus)" ; obo:IAO_0000115 "A beta2-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Fndc3c1 (Mmus), Ecrg4 (Mmus). It is distinguished from other Tanycyte NN cells by expression of Ecrg4. These cells are located in the Hypothalamus, brain , in or close to the regions: Median eminence, third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5250 Tanycyte NN_3." ; oboInOwl:hasExactSynonym "1174 Tanycyte NN_3", "5250 Tanycyte NN_3", "Fndc3c1 (Mmus), Ecrg4 (Mmus) expressing beta2-tanycyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "beta-2 tanycyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI1MCBUYW55Y3l0ZSBOTl8zAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4042020, obo:CL_4300362, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307083 obo:CLM_0010001 , , , , ; obo:CLM_0010003 obo:CLM_5007013, obo:CLM_5007984, obo:CLM_5022233, obo:CLM_5029833 ; obo:IAO_0000028 "Hypendymal NN (Mmus)" ; obo:IAO_0000115 "A hypendymal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Sspo (Mmus), Wfdc2 (Mmus). It is distinguished from other Astro-Epen cells by expression of Sspo, Wfdc2. These cells are located in the Midbrain, brain , in or close to the regions: third ventricle, posterior commissure, Subcommissural organ . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5263 Hypendymal NN_1." ; oboInOwl:hasExactSynonym "1177 Hypendymal NN_1", "324 Hypendymal NN", "5263 Hypendymal NN_1", "Sspo (Mmus), Wfdc2 (Mmus) expressing hypendymal cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "hypendemal cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2MyBIeXBlbmR5bWFsIE5OXzEAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNjMgSHlwZW5keW1hbCBOTl8xAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4023181, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307084 obo:CLM_0010001 , , , ; obo:CLM_0010003 obo:CLM_5007014, obo:CLM_5022234 ; obo:IAO_0000028 "CHOR NN_1 Tbc1d1 (Mmus)" ; obo:IAO_0000115 "A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus), Tbc1d1 (Mmus). It is distinguished from other CHOR NN cells by expression of Tbc1d1. These cells are located in the Cerebellum, brain , in or close to the regions: Paraflocculus, choroid plexus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5264 CHOR NN_1." ; oboInOwl:hasExactSynonym "2900040C04Rik (Mmus), Tbc1d1 (Mmus) expressing choroid plexus epithelial cell of brain (Mus musculus)", "5264 CHOR NN_1" ; a owl:Class ; rdfs:label "CHOR NN_1 Tbc1d1 choroid plexus epithelial cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2NCBDSE9SIE5OXzEAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNjQgQ0hPUiBOTl8xAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_4301608, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307085 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5007015, obo:CLM_5022235 ; obo:IAO_0000028 "CHOR NN_1 Slc17a8 (Mmus)" ; obo:IAO_0000115 "A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus), Slc17a8 (Mmus). It is distinguished from other CHOR NN cells by expression of Slc17a8. It is glutamatergic. These cells are located in the brain , in or close to the regions: choroid plexus, lateral ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5265 CHOR NN_1." ; oboInOwl:hasExactSynonym "2900040C04Rik (Mmus), Slc17a8 (Mmus) expressing choroid plexus epithelial cell of brain (Mus musculus)", "5265 CHOR NN_1" ; a owl:Class ; rdfs:label "CHOR NN_1 Slc17a8 choroid plexus epithelial cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2NSBDSE9SIE5OXzEAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNjUgQ0hPUiBOTl8xAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" ; rdfs:subClassOf obo:CL_0000686, obo:CL_4301608, _:genid18562, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307086 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5007016, obo:CLM_5022236 ; obo:IAO_0000028 "OPC NN_1 Neil3 (Mmus)" ; obo:IAO_0000115 "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Pclaf (Mmus), Mki67 (Mmus), Foxg1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Neil3, Foxg1. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5266 OPC NN_1." ; oboInOwl:hasExactSynonym "5266 OPC NN_1", "Pdgfra (Mmus), Pclaf (Mmus), Mki67 (Mmus), Foxg1 (Mmus) expressing oligodendrocyte precursor cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "OPC NN_1 Neil3 oligodendrocyte precursor cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2NiBPUEMgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2NiBPUEMgTk5fMQAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4300366, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307087 obo:CLM_0010001 , , , , ; obo:CLM_0010003 obo:CLM_5007017, obo:CLM_5022237 ; obo:IAO_0000028 "OPC NN_1 Irx2 (Mmus)" ; obo:IAO_0000115 "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Pclaf (Mmus), Irx2 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Neil3, Irx2. These cells are located in the Cerebellum, brain, Midbrain, Pons, Medulla . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5267 OPC NN_1." ; oboInOwl:hasExactSynonym "5267 OPC NN_1", "Pdgfra (Mmus), Pclaf (Mmus), Irx2 (Mmus) expressing oligodendrocyte precursor cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "OPC NN_1 Irx2 oligodendrocyte precursor cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4300366, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307088 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5007018, obo:CLM_5022238 ; obo:IAO_0000028 "OPC NN_1 Mms22l (Mmus)" ; obo:IAO_0000115 "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Mms22l (Mmus), Top2a (Mmus). It is distinguished from other OPC NN_1 cells by expression of Mms22l, Foxg1, Top2a. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5268 OPC NN_1." ; oboInOwl:hasExactSynonym "5268 OPC NN_1", "Pdgfra (Mmus), Olig1 (Mmus), Mms22l (Mmus), Top2a (Mmus) expressing oligodendrocyte precursor cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "OPC NN_1 Mms22l oligodendrocyte precursor cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2OCBPUEMgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2OCBPUEMgTk5fMQAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4300366, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307089 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5007019, obo:CLM_5022239 ; obo:IAO_0000028 "OPC NN_1 Col27a1 (Mmus)" ; obo:IAO_0000115 "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Col27a1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Col27a1. These cells are located in the Midbrain, Pons, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5269 OPC NN_1." ; oboInOwl:hasExactSynonym "5269 OPC NN_1", "Pdgfra (Mmus), Olig1 (Mmus), Col27a1 (Mmus) expressing oligodendrocyte precursor cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "OPC NN_1 Col27a1 oligodendrocyte precursor cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4300366, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307090 obo:CLM_0010001 , , , ; obo:CLM_0010003 obo:CLM_5007020, obo:CLM_5022240 ; obo:IAO_0000028 "OPC NN_1 Rmi2 (Mmus)" ; obo:IAO_0000115 "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Rmi2 (Mmus), Col27a1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Rmi2, Col27a1. These cells are located in the Hypothalamus, Midbrain, Pallidum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5270 OPC NN_1." ; oboInOwl:hasExactSynonym "5270 OPC NN_1", "Pdgfra (Mmus), Olig1 (Mmus), Rmi2 (Mmus), Col27a1 (Mmus) expressing oligodendrocyte precursor cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "OPC NN_1 Rmi2 oligodendrocyte precursor cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4300366, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307091 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5007021, obo:CLM_5022241 ; obo:IAO_0000028 "OPC NN_2 (Mmus)" ; obo:IAO_0000115 "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Cenpf (Mmus), Cenpa (Mmus). It is distinguished from other OPC NN cells by expression of Cenpa. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5271 OPC NN_2." ; oboInOwl:hasExactSynonym "1180 OPC NN_2", "5271 OPC NN_2", "Pdgfra (Mmus), Cenpf (Mmus), Cenpa (Mmus) expressing oligodendrocyte precursor cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "OPC NN_2 oligodendrocyte precursor cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4300366, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307092 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5007022, obo:CLM_5022242 ; obo:IAO_0000028 "COP NN_1 Rgcc (Mmus)" ; obo:IAO_0000115 "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bmp4 (Mmus), Zfp36l1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Rgcc, Plpp4. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5272 COP NN_1." ; oboInOwl:hasExactSynonym "5272 COP NN_1", "Gpr17 (Mmus), Bmp4 (Mmus), Zfp36l1 (Mmus) expressing committed oligodendrocyte precursor of brain (Mus musculus)" ; a owl:Class ; rdfs:label "COP NN_1 Rgcc committed oligodendrocyte precursor (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4301611, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307093 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5007023, obo:CLM_5022243 ; obo:IAO_0000028 "COP NN_1 9130019P16Rik (Mmus)" ; obo:IAO_0000115 "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Gp1bb (Mmus), Pdzd2 (Mmus), Plekhg1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Rgcc, 9130019P16Rik. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5273 COP NN_1." ; oboInOwl:hasExactSynonym "5273 COP NN_1", "Gpr17 (Mmus), Gp1bb (Mmus), Pdzd2 (Mmus), Plekhg1 (Mmus) expressing committed oligodendrocyte precursor of brain (Mus musculus)" ; a owl:Class ; rdfs:label "COP NN_1 9130019P16Rik committed oligodendrocyte precursor (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4301611, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307094 obo:CLM_0010001 ; obo:CLM_0010003 obo:CLM_5007024, obo:CLM_5022244 ; obo:IAO_0000028 "COP NN_1 C1ql1 (Mmus)" ; obo:IAO_0000115 "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bgn (Mmus), Gstp1 (Mmus), C1ql1 (Mmus). It is distinguished from other COP NN_1 cells by expression of C1ql1, Gstp1. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5274 COP NN_1." ; oboInOwl:hasExactSynonym "5274 COP NN_1", "Gpr17 (Mmus), Bgn (Mmus), Gstp1 (Mmus), C1ql1 (Mmus) expressing committed oligodendrocyte precursor of brain (Mus musculus)" ; a owl:Class ; rdfs:label "COP NN_1 C1ql1 committed oligodendrocyte precursor (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4301611, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307095 obo:CLM_0010001 ; obo:CLM_0010003 obo:CLM_5007025, obo:CLM_5022245 ; obo:IAO_0000028 "COP NN_1 Bmp4 (Mmus)" ; obo:IAO_0000115 "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Bmp4 (Mmus), Mob3b (Mmus). It is distinguished from other COP NN_1 cells by expression of Bmp4, Mob3b. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5275 COP NN_1." ; oboInOwl:hasExactSynonym "5275 COP NN_1", "9630013A20Rik (Mmus), Bmp4 (Mmus), Mob3b (Mmus) expressing committed oligodendrocyte precursor of brain (Mus musculus)" ; a owl:Class ; rdfs:label "COP NN_1 Bmp4 committed oligodendrocyte precursor (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4301611, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307096 obo:CLM_0010001 ; obo:CLM_0010003 obo:CLM_5007026, obo:CLM_5022246 ; obo:IAO_0000028 "COP NN_1 Vwc2 (Mmus)" ; obo:IAO_0000115 "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Rab32 (Mmus), Opalin (Mmus). It is distinguished from other COP NN_1 cells by expression of Vwc2, Opalin. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5276 COP NN_1." ; oboInOwl:hasExactSynonym "5276 COP NN_1", "9630013A20Rik (Mmus), Rab32 (Mmus), Opalin (Mmus) expressing committed oligodendrocyte precursor of brain (Mus musculus)" ; a owl:Class ; rdfs:label "COP NN_1 Vwc2 committed oligodendrocyte precursor (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4301611, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307097 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5007027, obo:CLM_5022247 ; obo:IAO_0000028 "COP NN_1 Cck (Mmus)" ; obo:IAO_0000115 "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Bmp4 (Mmus), Cck (Mmus), Ptger1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Bmp4, Cck, Ptger1. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5277 COP NN_1." ; oboInOwl:hasExactSynonym "5277 COP NN_1", "9630013A20Rik (Mmus), Bmp4 (Mmus), Cck (Mmus), Ptger1 (Mmus) expressing committed oligodendrocyte precursor of brain (Mus musculus)" ; a owl:Class ; rdfs:label "COP NN_1 Cck committed oligodendrocyte precursor (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4301611, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307098 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5007028, obo:CLM_5022248 ; obo:IAO_0000028 "NFOL NN_2 9630013A20Rik (Mmus)" ; obo:IAO_0000115 "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Grin2b (Mmus). It is distinguished from other NFOL NN_2 cells by expression of 9630013A20Rik, Grin2b. These cells are located in the Midbrain, Thalamus, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5278 NFOL NN_2." ; oboInOwl:hasExactSynonym "5278 NFOL NN_2", "9630013A20Rik (Mmus), Grin2b (Mmus) expressing newly formed oligodendrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "NFOL NN_2 9630013A20Rik newly formed oligodendrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3OCBORk9MIE5OXzIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNzggTkZPTCBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4301612, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307099 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5007029, obo:CLM_5022249 ; obo:IAO_0000028 "NFOL NN_2 Dbx2 (Mmus)" ; obo:IAO_0000115 "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Dbx2 (Mmus), Rassf10 (Mmus). It is distinguished from other NFOL NN_2 cells by expression of Dbx2, Rassf10. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5279 NFOL NN_2." ; oboInOwl:hasExactSynonym "5279 NFOL NN_2", "9630013A20Rik (Mmus), Dbx2 (Mmus), Rassf10 (Mmus) expressing newly formed oligodendrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "NFOL NN_2 Dbx2 newly formed oligodendrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3OSBORk9MIE5OXzIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNzkgTkZPTCBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4301612, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307100 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5007030, obo:CLM_5022250 ; obo:IAO_0000028 "NFOL NN_2 Rgs16 (Mmus)" ; obo:IAO_0000115 "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Rgs16 (Mmus), Rhbdl2 (Mmus). It is distinguished from other NFOL NN_2 cells by expression of Rgs16, Rhbdl2. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5280 NFOL NN_2." ; oboInOwl:hasExactSynonym "5280 NFOL NN_2", "9630013A20Rik (Mmus), Rgs16 (Mmus), Rhbdl2 (Mmus) expressing newly formed oligodendrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "NFOL NN_2 Rgs16 newly formed oligodendrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MCBORk9MIE5OXzIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyODAgTkZPTCBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4301612, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307101 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5007031, obo:CLM_5022251 ; obo:IAO_0000028 "NFOL NN_2 Il23a (Mmus)" ; obo:IAO_0000115 "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Piezo2 (Mmus), Ptprb (Mmus). It is distinguished from other NFOL NN_2 cells by expression of Il23a, Opalin, Ptprb. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5281 NFOL NN_2." ; oboInOwl:hasExactSynonym "5281 NFOL NN_2", "9630013A20Rik (Mmus), Piezo2 (Mmus), Ptprb (Mmus) expressing newly formed oligodendrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "NFOL NN_2 Il23a newly formed oligodendrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MSBORk9MIE5OXzIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyODEgTkZPTCBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4301612, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307102 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5007032, obo:CLM_5022252 ; obo:IAO_0000028 "MFOL NN_3 Cxcl12 (Mmus)" ; obo:IAO_0000115 "A myelin-forming oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Opalin (Mmus), Cxcl12 (Mmus), Efhd1 (Mmus). It is distinguished from other MFOL NN_3 cells by expression of Cxcl12, Efhd1. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5282 MFOL NN_3." ; oboInOwl:hasExactSynonym "5282 MFOL NN_3", "Opalin (Mmus), Cxcl12 (Mmus), Efhd1 (Mmus) expressing myelin-forming oligodendrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "MFOL NN_3 Cxcl12 myelin-forming oligodendrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MiBNRk9MIE5OXzMAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyODIgTUZPTCBOTl8zAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4301613, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307103 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5007033, obo:CLM_5022253 ; obo:IAO_0000028 "MFOL NN_3 Il23a (Mmus)" ; obo:IAO_0000115 "A myelin-forming oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Ppp1r14a (Mmus), Mroh3 (Mmus). It is distinguished from other MFOL NN_3 cells by expression of Il23a, Ppp1r14a. These cells are located in the Midbrain, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5283 MFOL NN_3." ; oboInOwl:hasExactSynonym "5283 MFOL NN_3", "9630013A20Rik (Mmus), Ppp1r14a (Mmus), Mroh3 (Mmus) expressing myelin-forming oligodendrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "MFOL NN_3 Il23a myelin-forming oligodendrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MyBNRk9MIE5OXzMAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyODMgTUZPTCBOTl8zAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4301613, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307104 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5007034, obo:CLM_5022254 ; obo:IAO_0000028 "MOL NN_4 Plin3 (Mmus)" ; obo:IAO_0000115 "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Prr5l (Mmus), Hapln2 (Mmus), Enpp6 (Mmus), Grm7 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Plin3, Grm7. These cells are located in the Medulla, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5284 MOL NN_4." ; oboInOwl:hasExactSynonym "5284 MOL NN_4", "Prr5l (Mmus), Hapln2 (Mmus), Enpp6 (Mmus), Grm7 (Mmus) expressing mature myelinating oligodendrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "MOL NN_4 Plin3 mature myelinating oligodendrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4301614, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307105 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5007035, obo:CLM_5022255 ; obo:IAO_0000028 "MOL NN_4 Spock3 (Mmus)" ; obo:IAO_0000115 "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), A230001M10Rik (Mmus), Spock3 (Mmus), Rhoj (Mmus). It is distinguished from other MOL NN_4 cells by expression of Spock3, Rhoj. These cells are located in the Midbrain, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5285 MOL NN_4." ; oboInOwl:hasExactSynonym "5285 MOL NN_4", "Cldn11 (Mmus), A230001M10Rik (Mmus), Spock3 (Mmus), Rhoj (Mmus) expressing mature myelinating oligodendrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "MOL NN_4 Spock3 mature myelinating oligodendrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4301614, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307106 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5007036, obo:CLM_5022256 ; obo:IAO_0000028 "MOL NN_4 Art3 (Mmus)" ; obo:IAO_0000115 "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Klk6 (Mmus), Dlc1 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Art3. These cells are located in the Medulla, Pons, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5286 MOL NN_4." ; oboInOwl:hasExactSynonym "5286 MOL NN_4", "Apod (Mmus), Klk6 (Mmus), Dlc1 (Mmus) expressing mature myelinating oligodendrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "MOL NN_4 Art3 mature myelinating oligodendrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4301614, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307107 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5007037, obo:CLM_5022257 ; obo:IAO_0000028 "MOL NN_4 Il33 (Mmus)" ; obo:IAO_0000115 "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Opalin (Mmus), Grm3 (Mmus), Gm5087 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Il33, Gm5087. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5287 MOL NN_4." ; oboInOwl:hasExactSynonym "5287 MOL NN_4", "Opalin (Mmus), Grm3 (Mmus), Gm5087 (Mmus) expressing mature myelinating oligodendrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "MOL NN_4 Il33 mature myelinating oligodendrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4301614, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307108 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5007038, obo:CLM_5022258 ; obo:IAO_0000028 "MOL NN_4 Sspo (Mmus)" ; obo:IAO_0000115 "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mog (Mmus), Anln (Mmus), Gm32633 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Sspo, Selenop. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5288 MOL NN_4." ; oboInOwl:hasExactSynonym "5288 MOL NN_4", "Mog (Mmus), Anln (Mmus), Gm32633 (Mmus) expressing mature myelinating oligodendrocyte of brain (Mus musculus)" ; a owl:Class ; rdfs:label "MOL NN_4 Sspo mature myelinating oligodendrocyte (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4OCBNT0wgTk5fNAAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4OCBNT0wgTk5fNAAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" ; rdfs:subClassOf obo:CL_4301614, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307109 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5007039, obo:CLM_5022259 ; obo:IAO_0000028 "OEC NN_1 Adamts12 (Mmus)" ; obo:IAO_0000115 "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn5 (Mmus), Adamts12 (Mmus). It is distinguished from other OEC cells by expression of Adamts12. These cells are located in the brain , in or close to the regions: olfactory nerve layer of main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5289 OEC NN_1." ; oboInOwl:hasExactSynonym "5289 OEC NN_1", "Cldn5 (Mmus), Adamts12 (Mmus) expressing olfactory ensheathing cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "OEC NN_1 Adamts12 olfactory ensheathing cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_32.h5ad" ; rdfs:subClassOf obo:CL_4301615, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307110 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5007040, obo:CLM_5022260 ; obo:IAO_0000028 "OEC NN_1 Gdpd4 (Mmus)" ; obo:IAO_0000115 "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Aqp1 (Mmus), Cldn5 (Mmus). It is distinguished from other OEC cells by expression of Gdpd4, Cldn5. These cells are located in the brain , in or close to the regions: olfactory nerve layer of main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5290 OEC NN_1." ; oboInOwl:hasExactSynonym "5290 OEC NN_1", "Apod (Mmus), Aqp1 (Mmus), Cldn5 (Mmus) expressing olfactory ensheathing cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "OEC NN_1 Gdpd4 olfactory ensheathing cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_32.h5ad" ; rdfs:subClassOf obo:CL_4301615, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307111 obo:CLM_0010001 , , , ; obo:CLM_0010003 obo:CLM_5007041, obo:CLM_5022261 ; obo:IAO_0000028 "OEC NN_1 A330076C08Rik (Mmus)" ; obo:IAO_0000115 "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Mybpc1 (Mmus), Syk (Mmus). It is distinguished from other OEC cells by expression of A330076C08Rik. These cells are located in the Olfactory areas, brain , in or close to the regions: olfactory nerve layer of main olfactory bulb, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5291 OEC NN_1." ; oboInOwl:hasExactSynonym "5291 OEC NN_1", "Apod (Mmus), Mybpc1 (Mmus), Syk (Mmus) expressing olfactory ensheathing cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "OEC NN_1 A330076C08Rik olfactory ensheathing cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_32.h5ad" ; rdfs:subClassOf obo:CL_4301615, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307112 obo:CLM_0010001 ; obo:CLM_0010003 obo:CLM_5007042, obo:CLM_5022262 ; obo:IAO_0000028 "OEC NN_1 Rasgef1c (Mmus)" ; obo:IAO_0000115 "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Mybpc1 (Mmus), Rasgef1c (Mmus). It is distinguished from other OEC cells by expression of Rasgef1c. It is glutamatergic. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5292 OEC NN_1." ; oboInOwl:hasExactSynonym "5292 OEC NN_1", "Apod (Mmus), Mybpc1 (Mmus), Rasgef1c (Mmus) expressing olfactory ensheathing cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "OEC NN_1 Rasgef1c olfactory ensheathing cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_32.h5ad" ; rdfs:subClassOf obo:CL_0000151, obo:CL_4301615, _:genid18900, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307113 obo:CLM_0010001 ; obo:CLM_0010003 obo:CLM_5007043, obo:CLM_5022263 ; obo:IAO_0000028 "ABC NN_1 Pde11a (Mmus)" ; obo:IAO_0000115 "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc47a1 (Mmus), Pde11a (Mmus). It is distinguished from other ABC NN cells by expression of Pde11a. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5293 ABC NN_1." ; oboInOwl:hasExactSynonym "5293 ABC NN_1", "Slc47a1 (Mmus), Pde11a (Mmus) expressing arachnoid barrier cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "ABC NN_1 Pde11a arachnoid barrier cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_33.h5ad" ; rdfs:subClassOf obo:CL_4301616, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307114 obo:CLM_0010001 ; obo:CLM_0010003 obo:CLM_5007044, obo:CLM_5022264 ; obo:IAO_0000028 "ABC NN_1 Dapl1 (Mmus)" ; obo:IAO_0000115 "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc47a1 (Mmus), Dapl1 (Mmus). It is distinguished from other ABC NN cells by expression of Dapl1. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5294 ABC NN_1." ; oboInOwl:hasExactSynonym "5294 ABC NN_1", "Slc47a1 (Mmus), Dapl1 (Mmus) expressing arachnoid barrier cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "ABC NN_1 Dapl1 arachnoid barrier cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_33.h5ad" ; rdfs:subClassOf obo:CL_4301616, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307115 obo:CLM_0010001 ; obo:CLM_0010003 obo:CLM_5007045, obo:CLM_5022265 ; obo:IAO_0000028 "ABC NN_1 Cubn (Mmus)" ; obo:IAO_0000115 "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Prg4 (Mmus), Cubn (Mmus). It is distinguished from other ABC NN cells by expression of Cubn. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5295 ABC NN_1." ; oboInOwl:hasExactSynonym "5295 ABC NN_1", "Prg4 (Mmus), Cubn (Mmus) expressing arachnoid barrier cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "ABC NN_1 Cubn arachnoid barrier cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_33.h5ad" ; rdfs:subClassOf obo:CL_4301616, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307132 obo:CLM_0010001 , ; obo:CLM_0010003 obo:CLM_5007062, obo:CLM_5007994, obo:CLM_5022282 ; obo:IAO_0000028 "Microglia NN (Mmus)" ; obo:IAO_0000115 "A microglial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C1qa (Mmus), Tmem119 (Mmus). It is distinguished from other Immune cells by expression of C1qa, Tmem119. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5312 Microglia NN_1." ; oboInOwl:hasExactSynonym "1194 Microglia NN_1", "334 Microglia NN", "5312 Microglia NN_1", "C1qa (Mmus), Tmem119 (Mmus) expressing microglial cell of brain (Mus musculus)" ; a owl:Class ; rdfs:label "microglial cell (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_34.h5ad" ; rdfs:subClassOf obo:CL_0000129, [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ], [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307133 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5007063, obo:CLM_5022283 ; obo:IAO_0000028 "BAM NN_1 Mrc1 (Mmus)" ; obo:IAO_0000115 "A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Pf4 (Mmus). It is distinguished from other BAM NN cells by expression of Mrc1, Pf4. These cells are located in the Medulla, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5313 BAM NN_1." ; oboInOwl:hasExactSynonym "5313 BAM NN_1", "Mrc1 (Mmus), Pf4 (Mmus) expressing border associated macrophage of brain (Mus musculus)" ; a owl:Class ; rdfs:label "BAM NN_1 Mrc1 border associated macrophage (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_34.h5ad" ; rdfs:subClassOf obo:CL_4301625, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CL_4307134 obo:CLM_0010001 , , ; obo:CLM_0010003 obo:CLM_5007064, obo:CLM_5022284 ; obo:IAO_0000028 "BAM NN_1 Fos (Mmus)" ; obo:IAO_0000115 "A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Pf4 (Mmus), Fos (Mmus). It is distinguished from other BAM NN cells by expression of Fos. These cells are located in the Isocortex, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5314 BAM NN_1." ; oboInOwl:hasExactSynonym "5314 BAM NN_1", "Mrc1 (Mmus), Pf4 (Mmus), Fos (Mmus) expressing border associated macrophage of brain (Mus musculus)" ; a owl:Class ; rdfs:label "BAM NN_1 Fos border associated macrophage (Mmus)" ; rdfs:seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D", "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_34.h5ad" ; rdfs:subClassOf obo:CL_4301625, [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:hasValue ; owl:onProperty obo:RO_0015001 ] ) ] . obo:CP_0000000 obo:IAO_0100001 obo:CL_0017500 ; a owl:Class ; rdfs:comment "ID was moved to the CL namespace. Use CL:0017500." ; rdfs:label "obsolete CP:0000000" ; owl:deprecated true . obo:CP_0000025 obo:IAO_0100001 obo:CL_0017501 ; a owl:Class ; rdfs:comment "ID was moved to the CL namespace. Use CL:0017501." ; rdfs:label "obsolete CP:0000025" ; owl:deprecated true . obo:CP_0000027 obo:IAO_0100001 obo:CL_0017502 ; a owl:Class ; rdfs:comment "ID was moved to the CL namespace. Use CL:0017502." ; rdfs:label "obsolete CP:0000027" ; owl:deprecated true . obo:CP_0000028 obo:IAO_0100001 obo:CL_0017503 ; a owl:Class ; rdfs:comment "ID was moved to the CL namespace. Use CL:0017503." ; rdfs:label "obsolete CP:0000028" ; owl:deprecated true . obo:CP_0000035 obo:IAO_0100001 obo:CL_0017504 ; a owl:Class ; rdfs:comment "ID was moved to the CL namespace. Use CL:0017504." ; rdfs:label "obsolete CP:0000035" ; owl:deprecated true . obo:CP_0000037 obo:IAO_0100001 obo:CL_0017505 ; a owl:Class ; rdfs:comment "ID was moved to the CL namespace. Use CL:0017505." ; rdfs:label "obsolete CP:0000037" ; owl:deprecated true . obo:CP_0000039 obo:IAO_0100001 obo:CL_0017506 ; a owl:Class ; rdfs:comment "ID was moved to the CL namespace. Use CL:0017506." ; rdfs:label "obsolete CP:0000039" ; owl:deprecated true . obo:CP_0000040 obo:IAO_0100001 obo:CL_0017507 ; a owl:Class ; rdfs:comment "ID was moved to the CL namespace. Use CL:0017507." ; rdfs:label "obsolete CP:0000040" ; owl:deprecated true . obo:CP_0000043 obo:IAO_0100001 obo:CL_0017508 ; a owl:Class ; rdfs:comment "ID was moved to the CL namespace. Use CL:0017508." ; rdfs:label "obsolete CP:0000043" ; owl:deprecated true . obo:GO_0000278 a owl:Class . obo:GO_0000768 a owl:Class . obo:GO_0000791 a owl:Class . obo:GO_0000792 a owl:Class . obo:GO_0001552 a owl:Class . obo:GO_0001667 a owl:Class . obo:GO_0001675 a owl:Class . obo:GO_0001696 a owl:Class . obo:GO_0001816 a owl:Class . obo:GO_0001820 a owl:Class . obo:GO_0001821 a owl:Class . obo:GO_0001913 a owl:Class . obo:GO_0001974 a owl:Class . obo:GO_0002001 a owl:Class . obo:GO_0002215 a owl:Class . obo:GO_0002227 a owl:Class . obo:GO_0002228 a owl:Class . obo:GO_0002244 a owl:Class . obo:GO_0002286 a owl:Class . obo:GO_0002288 a owl:Class . obo:GO_0002314 a owl:Class . obo:GO_0002335 a owl:Class . obo:GO_0002344 a owl:Class . obo:GO_0002349 a owl:Class . obo:GO_0002351 a owl:Class . obo:GO_0002369 a owl:Class . obo:GO_0002385 a owl:Class . obo:GO_0002387 a owl:Class . obo:GO_0002395 a owl:Class . obo:GO_0002407 a owl:Class . obo:GO_0002432 a owl:Class . obo:GO_0002456 a owl:Class . obo:GO_0002468 a owl:Class . obo:GO_0002474 a owl:Class . obo:GO_0002491 a owl:Class . obo:GO_0002495 a owl:Class . obo:GO_0002504 a owl:Class . obo:GO_0002515 a owl:Class . obo:GO_0002536 a owl:Class . obo:GO_0002537 a owl:Class . obo:GO_0002539 a owl:Class . obo:GO_0002540 a owl:Class . obo:GO_0002544 a owl:Class . obo:GO_0002548 a owl:Class . obo:GO_0002573 a owl:Class . obo:GO_0002574 a owl:Class . obo:GO_0002634 a owl:Class . obo:GO_0002660 a owl:Class . obo:GO_0002690 a owl:Class . obo:GO_0002775 a owl:Class . obo:GO_0002776 a owl:Class . obo:GO_0002790 a owl:Class . obo:GO_0002827 a owl:Class . obo:GO_0002828 a owl:Class . obo:GO_0002830 a owl:Class . obo:GO_0002905 a owl:Class . obo:GO_0003093 a owl:Class . obo:GO_0005044 a owl:Class . obo:GO_0005576 a owl:Class . obo:GO_0005634 a owl:Class . obo:GO_0005730 a owl:Class . obo:GO_0005737 a owl:Class . obo:GO_0005773 a owl:Class . obo:GO_0005794 a owl:Class . obo:GO_0005840 a owl:Class . obo:GO_0005902 a owl:Class . obo:GO_0005903 a owl:Class . obo:GO_0005927 a owl:Class . obo:GO_0005929 a owl:Class . obo:GO_0006699 a owl:Class . obo:GO_0006701 a owl:Class . obo:GO_0006709 a owl:Class . obo:GO_0006909 a owl:Class . obo:GO_0006954 a owl:Class . obo:GO_0006955 a owl:Class . obo:GO_0007113 a owl:Class . obo:GO_0007140 a owl:Class . obo:GO_0007142 a owl:Class . obo:GO_0007143 a owl:Class . obo:GO_0007147 a owl:Class . obo:GO_0007269 a owl:Class . obo:GO_0007283 a owl:Class . obo:GO_0007286 a owl:Class . obo:GO_0007288 a owl:Class . obo:GO_0007289 a owl:Class . obo:GO_0007585 a owl:Class . obo:GO_0007596 a owl:Class . obo:GO_0007601 a owl:Class . obo:GO_0007608 a owl:Class . obo:GO_0008015 a owl:Class . obo:GO_0008283 a owl:Class . obo:GO_0009306 a owl:Class . obo:GO_0009399 a owl:Class . obo:GO_0009566 a owl:Class . obo:GO_0009584 a owl:Class . obo:GO_0009589 a owl:Class . obo:GO_0014051 a owl:Class . obo:GO_0014055 a owl:Class . obo:GO_0015106 a owl:Class . obo:GO_0015671 a owl:Class . obo:GO_0015979 a owl:Class . obo:GO_0016446 a owl:Class . obo:GO_0016477 a owl:Class . obo:GO_0017145 a owl:Class . obo:GO_0019226 a owl:Class . obo:GO_0019626 a owl:Class . obo:GO_0019724 a owl:Class . obo:GO_0019814 a owl:Class . obo:GO_0019815 a owl:Class . obo:GO_0019882 a owl:Class . obo:GO_0022402 a owl:Class . obo:GO_0022414 a owl:Class . obo:GO_0030017 a owl:Class . obo:GO_0030057 a owl:Class . obo:GO_0030072 a owl:Class . obo:GO_0030073 a owl:Class . obo:GO_0030098 a owl:Class . obo:GO_0030099 a owl:Class . obo:GO_0030103 a owl:Class . obo:GO_0030141 a owl:Class . obo:GO_0030154 a owl:Class . obo:GO_0030187 a owl:Class . obo:GO_0030210 a owl:Class . obo:GO_0030213 a owl:Class . obo:GO_0030216 a owl:Class . obo:GO_0030217 a owl:Class . obo:GO_0030218 a owl:Class . obo:GO_0030219 a owl:Class . obo:GO_0030221 a owl:Class . obo:GO_0030222 a owl:Class . obo:GO_0030223 a owl:Class . obo:GO_0030224 a owl:Class . obo:GO_0030225 a owl:Class . obo:GO_0030252 a owl:Class . obo:GO_0030263 a owl:Class . obo:GO_0030316 a owl:Class . obo:GO_0030317 a owl:Class . obo:GO_0030424 a owl:Class . obo:GO_0030425 a owl:Class . obo:GO_0030851 a owl:Class . obo:GO_0030855 a owl:Class . obo:GO_0031012 a owl:Class . obo:GO_0031045 a owl:Class . obo:GO_0031201 a owl:Class . obo:GO_0031268 a owl:Class . obo:GO_0031294 a owl:Class . obo:GO_0031514 a owl:Class . obo:GO_0032274 a owl:Class . obo:GO_0032275 a owl:Class . obo:GO_0032289 a owl:Class . obo:GO_0032394 a owl:Class . obo:GO_0032606 a owl:Class . obo:GO_0032609 a owl:Class . obo:GO_0032611 a owl:Class . obo:GO_0032613 a owl:Class . obo:GO_0032616 a owl:Class . obo:GO_0032620 a owl:Class . obo:GO_0032623 a owl:Class . obo:GO_0032626 a owl:Class . obo:GO_0032633 a owl:Class . obo:GO_0032634 a owl:Class . obo:GO_0032635 a owl:Class . obo:GO_0032637 a owl:Class . obo:GO_0032638 a owl:Class . obo:GO_0032640 a owl:Class . obo:GO_0032689 a owl:Class . obo:GO_0032782 a owl:Class . obo:GO_0032816 a owl:Class . obo:GO_0032940 a owl:Class . obo:GO_0032991 a owl:Class . obo:GO_0033001 a owl:Class . obo:GO_0033093 a owl:Class . obo:GO_0033152 a owl:Class . obo:GO_0033326 a owl:Class . obo:GO_0033380 a owl:Class . obo:GO_0034102 a owl:Class . obo:GO_0035010 a owl:Class . obo:GO_0035369 a owl:Class . obo:GO_0035377 a owl:Class . obo:GO_0035898 a owl:Class . obo:GO_0035929 a owl:Class . obo:GO_0035931 a owl:Class . obo:GO_0035933 a owl:Class . obo:GO_0035935 a owl:Class . obo:GO_0035936 a owl:Class . obo:GO_0035938 a owl:Class . obo:GO_0036053 a owl:Class . obo:GO_0036160 a owl:Class . obo:GO_0036161 a owl:Class . obo:GO_0036162 a owl:Class . obo:GO_0036321 a owl:Class . obo:GO_0036334 a owl:Class . obo:GO_0036376 a owl:Class . obo:GO_0036457 a owl:Class . obo:GO_0042060 a owl:Class . obo:GO_0042101 a owl:Class . obo:GO_0042105 a owl:Class . obo:GO_0042106 a owl:Class . obo:GO_0042113 a owl:Class . obo:GO_0042130 a owl:Class . obo:GO_0042151 a owl:Class . obo:GO_0042267 a owl:Class . obo:GO_0042470 a owl:Class . obo:GO_0042483 a owl:Class . obo:GO_0042492 a owl:Class . obo:GO_0042554 a owl:Class . obo:GO_0042571 a owl:Class . obo:GO_0042582 a owl:Class . obo:GO_0042589 a owl:Class . obo:GO_0042590 a owl:Class . obo:GO_0042611 a owl:Class . obo:GO_0042613 a owl:Class . obo:GO_0042701 a owl:Class . obo:GO_0042742 a owl:Class . obo:GO_0043011 a owl:Class . obo:GO_0043129 a owl:Class . obo:GO_0043134 a owl:Class . obo:GO_0043195 a owl:Class . obo:GO_0043208 a owl:Class . obo:GO_0043209 a owl:Class . obo:GO_0043226 a owl:Class . obo:GO_0043277 a owl:Class . obo:GO_0043368 a owl:Class . obo:GO_0043370 a owl:Class . obo:GO_0043379 a owl:Class . obo:GO_0043384 a owl:Class . obo:GO_0044293 a owl:Class . obo:GO_0044316 a owl:Class . obo:GO_0044423 a owl:Class . obo:GO_0045058 a owl:Class . obo:GO_0045087 a owl:Class . obo:GO_0045190 a owl:Class . obo:GO_0045191 a owl:Class . obo:GO_0045428 a owl:Class . obo:GO_0045443 a owl:Class . obo:GO_0045453 a owl:Class . obo:GO_0045457 a owl:Class . obo:GO_0045580 a owl:Class . obo:GO_0045627 a owl:Class . obo:GO_0045630 a owl:Class . obo:GO_0045730 a owl:Class . obo:GO_0045765 a owl:Class . obo:GO_0045766 a owl:Class . obo:GO_0045830 a owl:Class . obo:GO_0046649 a owl:Class . obo:GO_0046651 a owl:Class . obo:GO_0046697 a owl:Class . obo:GO_0046717 a owl:Class . obo:GO_0046879 a owl:Class . obo:GO_0046930 a owl:Class . obo:GO_0048103 a owl:Class . obo:GO_0048137 a owl:Class . obo:GO_0048242 a owl:Class . obo:GO_0048243 a owl:Class . obo:GO_0048286 a owl:Class . obo:GO_0048295 a owl:Class . obo:GO_0048477 a owl:Class . obo:GO_0048771 a owl:Class . obo:GO_0048870 a owl:Class . obo:GO_0050728 a owl:Class . obo:GO_0050729 a owl:Class . obo:GO_0050776 a owl:Class . obo:GO_0050777 a owl:Class . obo:GO_0050893 a owl:Class . obo:GO_0050906 a owl:Class . obo:GO_0050907 a owl:Class . obo:GO_0050908 a owl:Class . obo:GO_0050910 a owl:Class . obo:GO_0050911 a owl:Class . obo:GO_0050912 a owl:Class . obo:GO_0050960 a owl:Class . obo:GO_0050974 a owl:Class . obo:GO_0050976 a owl:Class . obo:GO_0051024 a owl:Class . obo:GO_0051321 a owl:Class . obo:GO_0051458 a owl:Class . obo:GO_0060047 a owl:Class . obo:GO_0060054 a owl:Class . obo:GO_0060096 a owl:Class . obo:GO_0060374 a owl:Class . obo:GO_0061527 a owl:Class . obo:GO_0061533 a owl:Class . obo:GO_0061534 a owl:Class . obo:GO_0061535 a owl:Class . obo:GO_0061537 a owl:Class . obo:GO_0061538 a owl:Class . obo:GO_0061585 a owl:Class . obo:GO_0070091 a owl:Class . obo:GO_0070252 a owl:Class . obo:GO_0070253 a owl:Class . obo:GO_0070254 a owl:Class . obo:GO_0070278 a owl:Class . obo:GO_0070459 a owl:Class . obo:GO_0070460 a owl:Class . obo:GO_0070483 a owl:Class . obo:GO_0070820 a owl:Class . obo:GO_0070999 a owl:Class . obo:GO_0071707 a owl:Class . obo:GO_0071708 a owl:Class . obo:GO_0071735 a owl:Class . obo:GO_0071736 a owl:Class . obo:GO_0071738 a owl:Class . obo:GO_0071739 a owl:Class . obo:GO_0071742 a owl:Class . obo:GO_0071743 a owl:Class . obo:GO_0071745 a owl:Class . obo:GO_0071746 a owl:Class . obo:GO_0071753 a owl:Class . obo:GO_0071754 a owl:Class . obo:GO_0071971 a owl:Class . obo:GO_0072091 a owl:Class . obo:GO_0090023 a owl:Class . obo:GO_0097186 a owl:Class . obo:GO_0097208 a owl:Class . obo:GO_0097209 a owl:Class . obo:GO_0097722 a owl:Class . obo:GO_0097729 a owl:Class . obo:GO_0097730 a owl:Class . obo:GO_0098522 a owl:Class . obo:GO_0098535 a owl:Class . obo:GO_0098594 a owl:Class . obo:GO_0098754 a owl:Class . obo:GO_0098976 a owl:Class . obo:GO_0099096 a owl:Class . obo:GO_0120178 a owl:Class . obo:GO_0120327 a owl:Class . obo:GO_0151001 a owl:Class . obo:GO_0160043 a owl:Class . obo:GO_1900133 a owl:Class . obo:GO_1904320 a owl:Class . obo:GO_1990573 a owl:Class . obo:GO_2001013 a owl:Class . obo:IAO_0000028 a owl:AnnotationProperty . obo:IAO_0000115 a owl:AnnotationProperty . obo:IAO_0000116 a owl:AnnotationProperty . obo:IAO_0000231 a owl:AnnotationProperty . obo:IAO_0000233 a owl:AnnotationProperty . obo:IAO_0000424 a owl:AnnotationProperty . obo:IAO_0000700 a owl:AnnotationProperty . obo:IAO_0100001 a owl:AnnotationProperty . obo:NCBITaxon_10090 a owl:Class . obo:NCBITaxon_131567 a owl:Class . obo:NCBITaxon_142796 a owl:Class . obo:NCBITaxon_2759 a owl:Class . obo:NCBITaxon_32443 a owl:Class . obo:NCBITaxon_33208 a owl:Class . obo:NCBITaxon_33317 a owl:Class . obo:NCBITaxon_40674 a owl:Class . obo:NCBITaxon_4751 a owl:Class . obo:NCBITaxon_4896 a owl:Class . obo:NCBITaxon_50557 a owl:Class . obo:NCBITaxon_6073 a owl:Class . obo:NCBITaxon_6237 a owl:Class . obo:NCBITaxon_6656 a owl:Class . obo:NCBITaxon_7742 a owl:Class . obo:NCBITaxon_9606 a owl:Class . obo:OBI_0000070 a owl:AnnotationProperty . obo:PATO_0000405 a owl:Class . obo:PATO_0000460 a owl:Class . obo:PATO_0000586 a owl:Class . obo:PATO_0000587 a owl:Class . obo:PATO_0001365 a owl:Class . obo:PATO_0001375 a owl:Class . obo:PATO_0001377 a owl:Class . obo:PATO_0001393 a owl:Class . obo:PATO_0001394 a owl:Class . obo:PATO_0001400 a owl:Class . obo:PATO_0001401 a owl:Class . obo:PATO_0001402 a owl:Class . obo:PATO_0001405 a owl:Class . obo:PATO_0001406 a owl:Class . obo:PATO_0001407 a owl:Class . obo:PATO_0001410 a owl:Class . obo:PATO_0001501 a owl:Class . obo:PATO_0001603 a owl:Class . obo:PATO_0001604 a owl:Class . obo:PATO_0001870 a owl:Class . obo:PATO_0001871 a owl:Class . obo:PATO_0001872 a owl:Class . obo:PATO_0001874 a owl:Class . obo:PATO_0001908 a owl:Class . obo:PATO_0001979 a owl:Class . obo:PATO_0002011 a owl:Class . obo:PATO_0002039 a owl:Class . obo:PATO_0002064 a owl:Class . obo:PATO_0002094 a owl:Class . obo:PATO_0002097 a owl:Class . obo:PATO_0002354 a owl:Class . obo:PATO_0002418 a owl:Class . obo:PATO_0002478 a owl:Class . obo:PATO_0002479 a owl:Class . obo:PATO_0002505 a owl:Class . obo:PATO_0002506 a owl:Class . obo:PATO_0010007 a owl:Class . obo:PATO_0040072 a owl:Class . obo:PATO_0045026 a owl:Class . obo:PATO_0070001 a owl:Class . obo:PATO_0070002 a owl:Class . obo:PATO_0070003 a owl:Class . obo:PATO_0070004 a owl:Class . 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obo:PR_000006169 a owl:Class . obo:PR_000006172 a owl:Class . obo:PR_000006294 a owl:Class . obo:PR_000006611 a owl:Class . obo:PR_000007152 a owl:Class . obo:PR_000007204 a owl:Class . obo:PR_000007431 a owl:Class . obo:PR_000007479 a owl:Class . obo:PR_000007489 a owl:Class . obo:PR_000007597 a owl:Class . obo:PR_000007643 a owl:Class . obo:PR_000007785 a owl:Class . obo:PR_000007806 a owl:Class . obo:PR_000007857 a owl:Class . obo:PR_000007858 a owl:Class . obo:PR_000007939 a owl:Class . obo:PR_000008467 a owl:Class . obo:PR_000008857 a owl:Class . obo:PR_000008982 a owl:Class . obo:PR_000008994 a owl:Class . obo:PR_000009127 a owl:Class . obo:PR_000009129 a owl:Class . obo:PR_000009143 a owl:Class . obo:PR_000009344 a owl:Class . obo:PR_000009616 a owl:Class . obo:PR_000009618 a owl:Class . obo:PR_000009619 a owl:Class . obo:PR_000009623 a owl:Class . obo:PR_000009725 a owl:Class . obo:PR_000009766 a owl:Class . obo:PR_000009978 a owl:Class . obo:PR_000010317 a owl:Class . 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obo:PR_000016401 a owl:Class . obo:PR_000016626 a owl:Class . obo:PR_000017298 a owl:Class . obo:PR_000017299 a owl:Class . obo:PR_000020924 a owl:Class . obo:PR_000022006 a owl:Class . obo:PR_000025402 a owl:Class . obo:PR_000025403 a owl:Class . obo:PR_000027226 a owl:Class . obo:PR_000032148 a owl:Class . obo:PR_000032533 a owl:Class . obo:PR_O43699 a owl:Class . obo:PR_O76036 a owl:Class . obo:PR_O95944 a owl:Class . obo:PR_O95971 a owl:Class . obo:PR_P01589 a owl:Class . obo:PR_P09240 a owl:Class . obo:PR_P10721 a owl:Class . obo:PR_P11087 a owl:Class . obo:PR_P13591 a owl:Class . obo:PR_P16871 a owl:Class . obo:PR_P23771 a owl:Class . obo:PR_P24529 a owl:Class . obo:PR_P26618 a owl:Class . obo:PR_P28906 a owl:Class . obo:PR_P30530 a owl:Class . obo:PR_P32648 a owl:Class . obo:PR_P38570 a owl:Class . obo:PR_P49961 a owl:Class . obo:PR_P50481 a owl:Class . obo:PR_P51885 a owl:Class . obo:PR_P56199 a owl:Class . obo:PR_P60041 a owl:Class . obo:PR_Q12918 a owl:Class . obo:PR_Q8NFU0 a owl:Class . obo:PR_Q8R4I7 a owl:Class . obo:PR_Q96E93 a owl:Class . obo:PR_Q9D387 a owl:Class . obo:PR_Q9ER75 a owl:Class . obo:PR_Q9UL17 a owl:Class . obo:PR_Q9Y5Y4 a owl:Class . obo:RO_0000053 a owl:ObjectProperty . obo:RO_0000056 a owl:ObjectProperty . obo:RO_0000086 a owl:ObjectProperty . obo:RO_0001000 a owl:ObjectProperty . obo:RO_0001025 a owl:ObjectProperty . obo:RO_0002100 a owl:ObjectProperty . obo:RO_0002101 a owl:ObjectProperty . obo:RO_0002102 a owl:ObjectProperty . obo:RO_0002103 a owl:ObjectProperty . obo:RO_0002104 a owl:ObjectProperty . obo:RO_0002113 a owl:ObjectProperty . obo:RO_0002120 a owl:ObjectProperty . obo:RO_0002130 a owl:ObjectProperty . obo:RO_0002131 a owl:ObjectProperty . obo:RO_0002134 a owl:ObjectProperty . obo:RO_0002161 a owl:AnnotationProperty . obo:RO_0002162 a owl:ObjectProperty . obo:RO_0002170 a owl:ObjectProperty . obo:RO_0002175 a owl:AnnotationProperty . obo:RO_0002202 a owl:ObjectProperty . obo:RO_0002203 a owl:ObjectProperty . obo:RO_0002207 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obo:UBERON_0004903 a owl:Class . obo:UBERON_0005096 a owl:Class . obo:UBERON_0005097 a owl:Class . obo:UBERON_0005099 a owl:Class . obo:UBERON_0005100 a owl:Class . obo:UBERON_0005101 a owl:Class . obo:UBERON_0005102 a owl:Class . obo:UBERON_0005146 a owl:Class . obo:UBERON_0005164 a owl:Class . obo:UBERON_0005167 a owl:Class . obo:UBERON_0005168 a owl:Class . obo:UBERON_0005169 a owl:Class . obo:UBERON_0005176 a owl:Class . obo:UBERON_0005185 a owl:Class . obo:UBERON_0005203 a owl:Class . obo:UBERON_0005206 a owl:Class . obo:UBERON_0005211 a owl:Class . obo:UBERON_0005212 a owl:Class . obo:UBERON_0005213 a owl:Class . obo:UBERON_0005214 a owl:Class . obo:UBERON_0005215 a owl:Class . obo:UBERON_0005268 a owl:Class . obo:UBERON_0005269 a owl:Class . obo:UBERON_0005270 a owl:Class . obo:UBERON_0005271 a owl:Class . obo:UBERON_0005310 a owl:Class . obo:UBERON_0005317 a owl:Class . obo:UBERON_0005329 a owl:Class . obo:UBERON_0005363 a owl:Class . obo:UBERON_0005364 a owl:Class . obo:UBERON_0005375 a owl:Class . obo:UBERON_0005376 a owl:Class . obo:UBERON_0005377 a owl:Class . obo:UBERON_0005378 a owl:Class . obo:UBERON_0005381 a owl:Class . obo:UBERON_0005382 a owl:Class . obo:UBERON_0005384 a owl:Class . obo:UBERON_0005385 a owl:Class . obo:UBERON_0005388 a owl:Class . obo:UBERON_0005390 a owl:Class . obo:UBERON_0005391 a owl:Class . obo:UBERON_0005392 a owl:Class . obo:UBERON_0005393 a owl:Class . obo:UBERON_0005394 a owl:Class . obo:UBERON_0005395 a owl:Class . obo:UBERON_0005396 a owl:Class . obo:UBERON_0005403 a owl:Class . obo:UBERON_0005406 a owl:Class . obo:UBERON_0005408 a owl:Class . obo:UBERON_0005453 a owl:Class . obo:UBERON_0005463 a owl:Class . obo:UBERON_0005479 a owl:Class . obo:UBERON_0005725 a owl:Class . obo:UBERON_0005734 a owl:Class . obo:UBERON_0005742 a owl:Class . obo:UBERON_0005750 a owl:Class . obo:UBERON_0005751 a owl:Class . obo:UBERON_0005933 a owl:Class . obo:UBERON_0005941 a owl:Class . obo:UBERON_0005942 a owl:Class . obo:UBERON_0005969 a owl:Class . obo:UBERON_0005986 a owl:Class . obo:UBERON_0005987 a owl:Class . obo:UBERON_0006004 a owl:Class . obo:UBERON_0006250 a owl:Class . obo:UBERON_0006334 a owl:Class . obo:UBERON_0006341 a owl:Class . obo:UBERON_0006376 a owl:Class . obo:UBERON_0006660 a owl:Class . obo:UBERON_0006725 a owl:Class . obo:UBERON_0006761 a owl:Class . obo:UBERON_0006763 a owl:Class . obo:UBERON_0006815 a owl:Class . obo:UBERON_0006841 a owl:Class . obo:UBERON_0006851 a owl:Class . obo:UBERON_0006853 a owl:Class . obo:UBERON_0006854 a owl:Class . obo:UBERON_0006855 a owl:Class . obo:UBERON_0006915 a owl:Class . obo:UBERON_0006920 a owl:Class . obo:UBERON_0006935 a owl:Class . obo:UBERON_0006936 a owl:Class . obo:UBERON_0006955 a owl:Class . obo:UBERON_0006960 a owl:Class . obo:UBERON_0006964 a owl:Class . obo:UBERON_0007100 a owl:Class . obo:UBERON_0007177 a owl:Class . obo:UBERON_0007196 a owl:Class . obo:UBERON_0007221 a owl:Class . obo:UBERON_0007240 a owl:Class . obo:UBERON_0007376 a owl:Class . obo:UBERON_0007589 a owl:Class . obo:UBERON_0007846 a owl:Class . obo:UBERON_0008198 a owl:Class . obo:UBERON_0008266 a owl:Class . obo:UBERON_0008305 a owl:Class . obo:UBERON_0008339 a owl:Class . obo:UBERON_0008345 a owl:Class . obo:UBERON_0008346 a owl:Class . obo:UBERON_0008397 a owl:Class . obo:UBERON_0008404 a owl:Class . obo:UBERON_0008856 a owl:Class . obo:UBERON_0008857 a owl:Class . obo:UBERON_0008859 a owl:Class . obo:UBERON_0008861 a owl:Class . obo:UBERON_0008862 a owl:Class . obo:UBERON_0008883 a owl:Class . obo:UBERON_0008904 a owl:Class . obo:UBERON_0008906 a owl:Class . obo:UBERON_0008922 a owl:Class . obo:UBERON_0008923 a owl:Class . obo:UBERON_0008924 a owl:Class . obo:UBERON_0008925 a owl:Class . obo:UBERON_0008926 a owl:Class . obo:UBERON_0008927 a owl:Class . obo:UBERON_0008929 a owl:Class . obo:UBERON_0008946 a owl:Class . obo:UBERON_0008998 a owl:Class . obo:UBERON_0009015 a owl:Class . obo:UBERON_0009039 a owl:Class . obo:UBERON_0009089 a owl:Class . obo:UBERON_0009090 a owl:Class . obo:UBERON_0009091 a owl:Class . obo:UBERON_0009092 a owl:Class . obo:UBERON_0009093 a owl:Class . obo:UBERON_0009095 a owl:Class . obo:UBERON_0009202 a owl:Class . obo:UBERON_0009566 a owl:Class . obo:UBERON_0009697 a owl:Class . obo:UBERON_0009731 a owl:Class . obo:UBERON_0009738 a owl:Class . obo:UBERON_0009739 a owl:Class . obo:UBERON_0009744 a owl:Class . obo:UBERON_0009841 a owl:Class . obo:UBERON_0009842 a owl:Class . obo:UBERON_0009851 a owl:Class . obo:UBERON_0009852 a owl:Class . obo:UBERON_0009859 a owl:Class . obo:UBERON_0009871 a owl:Class . obo:UBERON_0009882 a owl:Class . obo:UBERON_0009918 a owl:Class . obo:UBERON_0009966 a owl:Class . obo:UBERON_0009967 a owl:Class . obo:UBERON_0009969 a owl:Class . obo:UBERON_0009970 a owl:Class . obo:UBERON_0009971 a owl:Class . obo:UBERON_0010005 a owl:Class . obo:UBERON_0010038 a owl:Class . obo:UBERON_0010062 a owl:Class . obo:UBERON_0010077 a owl:Class . obo:UBERON_0010225 a owl:Class . obo:UBERON_0010302 a owl:Class . obo:UBERON_0010313 a owl:Class . obo:UBERON_0010397 a owl:Class . obo:UBERON_0010402 a owl:Class . obo:UBERON_0010417 a owl:Class . obo:UBERON_0010420 a owl:Class . obo:UBERON_0010523 a owl:Class . obo:UBERON_0010754 a owl:Class . obo:UBERON_0010996 a owl:Class . obo:UBERON_0011148 a owl:Class . obo:UBERON_0011172 a owl:Class . obo:UBERON_0011184 a owl:Class . obo:UBERON_0011189 a owl:Class . obo:UBERON_0011197 a owl:Class . obo:UBERON_0011595 a owl:Class . obo:UBERON_0011949 a owl:Class . obo:UBERON_0012168 a owl:Class . obo:UBERON_0012186 a owl:Class . obo:UBERON_0012251 a owl:Class . obo:UBERON_0012252 a owl:Class . obo:UBERON_0012276 a owl:Class . obo:UBERON_0012279 a owl:Class . obo:UBERON_0012363 a owl:Class . obo:UBERON_0012368 a owl:Class . obo:UBERON_0012375 a owl:Class . obo:UBERON_0012398 a owl:Class . obo:UBERON_0012399 a owl:Class . obo:UBERON_0012419 a owl:Class . obo:UBERON_0012429 a owl:Class . obo:UBERON_0012441 a owl:Class . obo:UBERON_0012498 a owl:Class . obo:UBERON_0013192 a owl:Class . obo:UBERON_0013485 a owl:Class . obo:UBERON_0013486 a owl:Class . obo:UBERON_0013606 a owl:Class . obo:UBERON_0013607 a owl:Class . obo:UBERON_0013615 a owl:Class . obo:UBERON_0013636 a owl:Class . obo:UBERON_0013694 a owl:Class . obo:UBERON_0013695 a owl:Class . obo:UBERON_0013696 a owl:Class . obo:UBERON_0013697 a owl:Class . obo:UBERON_0013739 a owl:Class . obo:UBERON_0013740 a owl:Class . obo:UBERON_0013755 a owl:Class . obo:UBERON_0013756 a owl:Class . obo:UBERON_0014451 a owl:Class . obo:UBERON_0014727 a owl:Class . obo:UBERON_0014729 a owl:Class . obo:UBERON_0015172 a owl:Class . obo:UBERON_0015716 a owl:Class . obo:UBERON_0015766 a owl:Class . obo:UBERON_0016405 a owl:Class . obo:UBERON_0016508 a owl:Class . obo:UBERON_0022281 a owl:Class . obo:UBERON_0022315 a owl:Class . obo:UBERON_0027368 a owl:Class . obo:UBERON_0027371 a owl:Class . obo:UBERON_0036007 a owl:Class . obo:UBERON_1000021 a owl:Class . obo:UBERON_2000120 a owl:Class . obo:UBERON_2000175 a owl:Class . obo:UBERON_2000425 a owl:Class . obo:UBERON_2001314 a owl:Class . obo:UBERON_2001391 a owl:Class . obo:UBERON_2001470 a owl:Class . obo:UBERON_8300000 a owl:Class . obo:UBERON_8400006 a owl:Class . obo:UBERON_8400007 a owl:Class . obo:UBERON_8400008 a owl:Class . obo:UBERON_8410003 a owl:Class . obo:UBERON_8410037 a owl:Class . obo:UBERON_8410038 a owl:Class . obo:UBERON_8410041 a owl:Class . obo:UBERON_8410042 a owl:Class . obo:UBERON_8410043 a owl:Class . obo:UBERON_8410050 a owl:Class . obo:UBERON_8410052 a owl:Class . obo:UBERON_8410053 a owl:Class . obo:UBERON_8410065 a owl:Class . obo:UBERON_8410066 a owl:Class . obo:UBERON_8410071 a owl:Class . obo:UBERON_8410072 a owl:Class . obo:UBERON_8410077 a owl:Class . obo:UBERON_8440000 a owl:Class . obo:UBERON_8440001 a owl:Class . obo:UBERON_8440002 a owl:Class . obo:UBERON_8440003 a owl:Class . obo:UBERON_8440005 a owl:Class . obo:UBERON_8440043 a owl:Class . obo:UBERON_8600001 a owl:Class . obo:UBERON_8600004 a owl:Class . obo:UBERON_8600014 a owl:Class . obo:UBERON_8600119 a owl:Class . obo:UBERON_8600120 a owl:Class . obo:UBERON_8600121 a owl:Class . obo:UBERON_8600122 a owl:Class . obo:UBERON_8600123 a owl:Class . obo:UBERON_8850000 a owl:Class . obo:UBERON_8910001 a owl:Class . cl:BDS_subset a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . cl:added_for_HCA a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . cl:blood_and_immune_upper_slim terms:date "2023-03-31T09:17:34Z"^^xsd:dateTime ; a owl:AnnotationProperty ; rdfs:comment "a subset of general classes related to blood and the immune system, primarily of hematopoietic origin" ; rdfs:label "blood_and_immune_upper_slim" ; rdfs:subPropertyOf oboInOwl:SubsetProperty . cl:eye_upper_slim a owl:AnnotationProperty ; rdfs:comment "a subset of general classes related to specific cell types in the eye." ; rdfs:label "eye_upper_slim" ; rdfs:subPropertyOf oboInOwl:SubsetProperty . cl:general_cell_types_upper_slim a owl:AnnotationProperty ; rdfs:comment "a subset of general classes of cell types in the cell ontology." ; rdfs:label "general_cell_types_upper_slim" ; rdfs:subPropertyOf oboInOwl:SubsetProperty . cl:has_high_plasma_membrane_amount obo:IAO_0000115 "OBSOLETE A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617)." ; obo:IAO_0000233 ; obo:IAO_0100001 obo:RO_0015015 ; a owl:ObjectProperty ; rdfs:label "obsolete has_high_plasma_membrane_amount" ; owl:deprecated true . cl:has_low_plasma_membrane_amount obo:IAO_0000115 "OBSOLETE A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617)." ; obo:IAO_0000233 ; obo:IAO_0100001 obo:RO_0015016 ; a owl:ObjectProperty ; rdfs:label "obsolete has_low_plasma_membrane_amount" ; owl:deprecated true . cl:kidney_upper_slim terms:date "2023-11-22T11:18:57Z"^^xsd:dateTime ; a owl:AnnotationProperty ; rdfs:comment "a subset of general classes related to specific cell types in the kidney" ; rdfs:label "kidney_upper_slim" ; rdfs:subPropertyOf oboInOwl:SubsetProperty . obo:IAO_0000700 obo:CL_0000000 ; dc:description "An ontology of cell types." ; dc:title "Cell Ontology" ; dc:type obo:IAO_8000001 ; terms:contributor , , , , , , , , ; terms:license ; a owl:Ontology ; rdfs:comment "See PMID:15693950, PMID:12799354, PMID:20123131, PMID:21208450; Contact Alexander Diehl, addiehl[at]buffalo.edu, university at buffalo." ; owl:versionIRI ; owl:versionInfo "2025-07-30" . dc:description a owl:AnnotationProperty . dc:license a owl:AnnotationProperty . dc:title a owl:AnnotationProperty . dc:type a owl:AnnotationProperty . terms:contributor a owl:AnnotationProperty . terms:date a owl:AnnotationProperty . terms:description a owl:AnnotationProperty . terms:licence a owl:AnnotationProperty . terms:license a owl:AnnotationProperty . oboInOwl:SubsetProperty a owl:AnnotationProperty . oboInOwl:SynonymTypeProperty a owl:AnnotationProperty . oboInOwl:consider a owl:AnnotationProperty . oboInOwl:creation_date a owl:AnnotationProperty . oboInOwl:evidence a owl:AnnotationProperty . oboInOwl:hasBroadSynonym a owl:AnnotationProperty . oboInOwl:hasDbXref a owl:AnnotationProperty . oboInOwl:hasExactSynonym a owl:AnnotationProperty . oboInOwl:hasNarrowSynonym a owl:AnnotationProperty . oboInOwl:hasOBONamespace a owl:AnnotationProperty . oboInOwl:hasRelatedSynonym a owl:AnnotationProperty . oboInOwl:hasSynonymType a owl:AnnotationProperty . oboInOwl:id a owl:AnnotationProperty . oboInOwl:inSubset a owl:AnnotationProperty . oboInOwl:is_inferred a owl:AnnotationProperty . oboInOwl:source a owl:AnnotationProperty . skos:prefLabel a owl:AnnotationProperty . foaf:depiction a owl:AnnotationProperty . a owl:Class . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . a owl:NamedIndividual . sssom:mapping_justification a owl:AnnotationProperty . [] oboInOwl:hasDbXref "PMID:19243617" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource cl:has_high_plasma_membrane_amount ; owl:annotatedTarget "OBSOLETE A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617)." . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000004 ; owl:annotatedTarget "OBSOLETE: A classification of cells by the organisms within which they are contained." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000151 ; owl:annotatedTarget "A cell that specializes in controlled release of one or more substances." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "PMID:34433485", "PMID:34772990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002301 ; owl:annotatedTarget "A resident stromal cell located in the synovial membrane and responsible for the production of immune-related cytokines and chemokines. This cell type secretes glycoproteins and hyaluronic acid, has abundant granular endoplasmic reticulum, but contains fewer vacuoles and vesicles." . [] oboInOwl:hasDbXref "PMID:23147896" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002301 ; owl:annotatedTarget "synovial fibroblast" . [] oboInOwl:hasDbXref "PMID:34433485", "https://en.wikipedia.org/wiki/Fibroblast-like_synoviocyte" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002301 ; owl:annotatedTarget "Type B synovial cells play a key role in the pathogenesis of chronic inflammatory diseases, such as rheumatoid arthritis, and are essential for the maintenance of normal joint functions. Fibroblast-like synoviocytes from different joints have different properties, which may contribute to the characteristic pattern of joint involvement in different types of arthritis." . [] oboInOwl:hasDbXref "PMID:10770586" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002302 ; owl:annotatedTarget _:genid8380 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002302 ; owl:annotatedTarget "A synovial cell that is macrophage-like, characterized by surface ruffles or lamellipodia, plasma membrane invaginations and associated micropinocytotic vesicles, Golgi apparatus and little granular endoplasmic reticulum." . [] oboInOwl:hasDbXref "PMID:10770586" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002302 ; owl:annotatedTarget "Type A cells are usually round and located in the upper part of the synovial intima." . [] oboInOwl:hasDbXref "PMID:15106942" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002303 ; owl:annotatedTarget "A cell that is part of pigmented ciliary epithelium. This cell type uptakes sodium and chloride ions from stromal interstitium and passes the ions to non-pigmented ciliary epithelial cells via gap junctions." . [] oboInOwl:hasDbXref "DOI:10.1016/S1569-2590(05)10005-6", "DOI:10.1111/j.1444-0938.2002.tb02384.x" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002303 ; owl:annotatedTarget """Pigmented ciliary epithelial cells, which are a type of pigment cell, have a crucial function within the eye's ciliary body. The ciliary body, located behind the iris, is one of the eye’s most vital structures and consists of two types of epithelial cells: the pigmented and the non-pigmented ciliary epithelial cells. The pigmented ciliary epithelial cells form the outer layer of the ciliary body and exhibit a black or brown pigmentation due to the melanin they contain. One key function of pigmented ciliary epithelial cells is to aid in the formation of aqueous humor, an intraocular fluid that nourishes the cornea and lens, and maintains intraocular pressure which is essential for the eye’s shape and light refraction. These cells facilitate this function in conjunction with the non-pigmented ciliary epithelial cells. Together, the pigmented and non-pigmented ciliary epithelial cells form a bilayer epithelium that allows the secretion of aqueous humor through a bi-directional fluid transport mechanism. Pigmented ciliary epithelial cells also contribute to the blood-aqueous barrier, a physiological frontier that controls the entry and exit of various substances from the blood to the aqueous humor and vice versa. The pigmentation in these cells, intensified by melanin, helps to absorb scattered light coming into the eye, reducing any potential damage and glare. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "https://doi.org/10.1016/j.exer.2003.09.021" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002303 ; owl:annotatedTarget "PE cell" . [] oboInOwl:hasDbXref "https://doi.org/10.1016/j.exer.2003.09.021" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002303 ; owl:annotatedTarget "In a consensus model of unidirectional secretion, aqueous humour is formed by transferring solute, principally NaCl, from stroma to posterior chamber, with water passively following the osmotic gradient. Unidirectional secretion comprises three sequential steps. First, NaCl is transferred from the stromal interstitium into the pigmented ciliary epithelial (PE) cells. Second, solute passes from the PE into the non-pigmented ciliary epithelial (NPE) cells through gap junctions. Finally, NPE cells release Na+ and Cl− into the aqueous humour." . [] a owl:Axiom ; rdfs:label "pigmented ciliary epithelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002303 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002303" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:15106942" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002304 ; owl:annotatedTarget "A cell that is part of non-pigmented ciliary epithelium. This cell type participates in aqueous humor formation by releasing solute, principally sodium and chloride ions received from pigmented epithelial cells via gap junctions, into the aqueous humor of the eye." . [] oboInOwl:hasDbXref "https://doi.org/10.1016/j.exer.2003.09.021" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002304 ; owl:annotatedTarget "NPE cell" . [] oboInOwl:hasDbXref "PMID:10913011" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002304 ; owl:annotatedTarget "nonpigmented ciliary epithelial cell" . [] oboInOwl:hasDbXref "https://doi.org/10.1016/j.exer.2003.09.021" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002304 ; owl:annotatedTarget "In a consensus model of unidirectional secretion, aqueous humour is formed by transferring solute, principally NaCl, from stroma to posterior chamber, with water passively following the osmotic gradient. Unidirectional secretion comprises three sequential steps. First, NaCl is transferred from the stromal interstitium into the pigmented ciliary epithelial (PE) cells. Second, solute passes from the PE into the non-pigmented ciliary epithelial (NPE) cells through gap junctions. Finally, NPE cells release Na+ and Cl− into the aqueous humour." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002305 ; owl:annotatedTarget obo:CL_1000494 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002305 ; owl:annotatedTarget "An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002306 ; owl:annotatedTarget obo:CL_1000494 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:1-4160-2328-3" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002306 ; owl:annotatedTarget "An epithelial cell of the proximal tubule of the kidney." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM778.SHGJ.294" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002306 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:1-4160-2328-3", "PMID:23799132" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002307 ; owl:annotatedTarget "A brush border epithelial cell located in the proximal tubule of the kidney, essential for reabsorbing substances like glucose and amino acids from the glomerular filtrate. These cells also secrete organic ions, playing a crucial role in maintaining kidney homeostasis, including electrolyte and acid-base balance, and excreting metabolic waste." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002308 ; owl:annotatedTarget "An epithelial cell of a skin gland." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002309 ; owl:annotatedTarget "A basophil chromphil cell of the anterior pitiutary gland that produce adrenocorticotropic hormone, melanocyte-stimulating hormone and lipotropin. This cell type is irregular in shape and has short dendritic processes which are inserted among other neighboring cells;" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002310 ; owl:annotatedTarget "An acidophil cell of the anterior pituitary gland that produces both prolactin and growth hormone." . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002311 ; owl:annotatedTarget "An acidophilic cell of the anterior pituitary that produces prolactin." . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002312 ; owl:annotatedTarget "An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002313 ; owl:annotatedTarget "An ecto-epithelial cell of the prostate gland that secretes hormones." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20837532" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002314 ; owl:annotatedTarget "An auditory epithelial support cell located in the vestibular epithelium that has many hallmarks of glial cells. This cell type express glial markers such as vimentin, S100, glutamate-aspartate transporter, low affinity neurotrophin receptor p75, glial fibrillary acidic protein, and proteolipid protein." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000152 ; owl:annotatedTarget "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002315 ; owl:annotatedTarget "An epithelial supporting cell located in the cochlea." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000152 ; owl:annotatedTarget "ZFA:0009092" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20837532" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002316 ; owl:annotatedTarget "A supporting cell of the vestibular epithelium." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002317 ; owl:annotatedTarget "An external limiting cell found in the vestibular epithelium." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:14592528" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002318 ; owl:annotatedTarget "A mesothelial cell capable of circulating in the blood by first losing its squamous character. This cell can incorporate into the regenerating mesothelium." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000153 ; owl:annotatedTarget "A cell that secretes glycosaminoglycans." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002319 ; owl:annotatedTarget "A cell that is part of the nervous system." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002320 ; owl:annotatedTarget "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0002320 ; owl:annotatedTarget "ZFA:0009392" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FMA:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002321 ; owl:annotatedTarget "A cell of the embryo." . [] oboInOwl:hasDbXref "DOI:10.1002/iub.1404", "DOI:10.1093/molehr/gan048", "https://www.ncbi.nlm.nih.gov/books/NBK9906/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002321 ; owl:annotatedTarget """Embryonic cells in metazoans, which include all multicellular animals, are biological units in their earliest developmental stages from conception until the organism is fully formed. They are derived from a fertilized egg, which undergoes a series of cell divisions to produce a multicellular organism. During the early phases of embryonic development, these cells exhibit pluripotency, meaning they possess the potential to differentiate into a diverse array of specialized cell types that constitute different body tissues and structures. The balance between cell proliferation and differentiation in embryonic cells is crucial for successful development. When cells continue to divide without differentiating, overgrowth may occur leading to conditions such as teratomas (tumors of embryonic cells). Conversely, if cell differentiation proceeds at the expense of cell proliferation, developmental anomalies could occur regarding size or mass of the organism or its parts. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000153 ; owl:annotatedTarget "ZFA:0009093" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0002321 ; owl:annotatedTarget "ZFA:0007089" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "embryonic cell (metazoa) on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002321 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002321" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "ISBN:068340007X", "PMID:18179856" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002322 ; owl:annotatedTarget "A stem cell of embryonic origin." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002323 ; owl:annotatedTarget obo:CL_0000349 . [] oboInOwl:hasDbXref "BFO:0000066", "GOC:tfm", "PMID:3211847" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002323 ; owl:annotatedTarget "A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:11250738", "PMID:19022771", "PMID:38059556" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002324 ; owl:annotatedTarget "A myoepithelial cell that is part of a mammary gland and is located in the basal layer. During lactation, a basal-myoepithelial cell of mammary gland contracts under the stimulation of oxytocin. In humans, a basal-myoepithelial cell of mammary gland can be identified by high levels of CD49f and low levels of EpCAM." . [] oboInOwl:hasDbXref "PMID:37694522" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0002324 ; owl:annotatedTarget "basal myoepithelial cell" . [] oboInOwl:hasDbXref "PMID:37380767" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0002324 ; owl:annotatedTarget "basal-myoepithelial cell" . [] oboInOwl:hasDbXref "PMID:11250738" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002324 ; owl:annotatedTarget "myoepithelial cell of mammary gland" . [] oboInOwl:hasDbXref "FMA:67800" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_0002324 ; owl:annotatedTarget "basal cell of lactiferous duct" . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002324 ; owl:annotatedTarget "B-Myo cell" . [] oboInOwl:hasDbXref "PMID:38059556" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002324 ; owl:annotatedTarget "BM" . [] oboInOwl:hasDbXref "PMID:37380767" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002324 ; owl:annotatedTarget "basal" . [] oboInOwl:hasDbXref "PMID:38059556" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002324 ; owl:annotatedTarget "Due inconsistencies in naming this and other mammary gland epithelial cell types, several mammary gland experts gathered for a breast atlas annotation jamboree organized by Chan-Zuckerberg initiative. They agreed to label this cell type as basal-myoepithelial cell (and abbreviated: B-Myo cell)." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002325 ; owl:annotatedTarget obo:CL_0002159 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19022771", "PMID:28717367", "PMID:35091553", "PMID:35377806", "doi:10.1177/156482659601700404" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002325 ; owl:annotatedTarget "A milk-producing glandular epithelial cell that is part of a mammary gland alveolus and differentiates from a luminal adaptive secretory precursor cell during secretory differentiation (also termed lactogenesis I). Following secretory activation (also termed lactogenesis II), a lactocyte is involved in the synthesis and/or transport of milk constituents including proteins, oligosaccharides, lactose, micronutrients, fat, hormones, immunoglobulins, and cytokines into the lumen of the lactating mammary gland." . [] oboInOwl:hasDbXref "PMID:19022771" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0002325 ; owl:annotatedTarget "mammary alveolar cell" . [] oboInOwl:hasDbXref "PMID:35091553" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002325 ; owl:annotatedTarget "lactaction-associated mammary epithelial cell" . [] oboInOwl:hasDbXref "PMID:35091553" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002325 ; owl:annotatedTarget "lactation-derived mammary cell" . [] oboInOwl:hasDbXref "PMID:35091553" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002325 ; owl:annotatedTarget "LMC" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19022771" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002326 ; owl:annotatedTarget "A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast." . [] oboInOwl:hasDbXref "PMID:21930782" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0002326 ; owl:annotatedTarget "mature luminal cell" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19022771" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002327 ; owl:annotatedTarget "An epithelial cell of the mammary gland." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002328 ; owl:annotatedTarget "An epithelial cell of the bronchus." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002329 ; owl:annotatedTarget "An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury." . [] oboInOwl:hasDbXref "DOI:10.1165/rcmb.2013-0049OC", "DOI:10.1186/s12931-014-0160-8", "DOI:10.2353/ajpath.2010.090870" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002329 ; owl:annotatedTarget """The basal epithelial cells of the tracheobronchial tree are critical components found in the lining of the airway passages, including the trachea and bronchi. They are keratin-5-positive, nonciliated, cuboidal cells and typically tightly attached to the basement membrane. In humans, the proportion of basal cells in the respiratory epithelium gradually decreases going down the tracheobronchial tree: they represent approximately 34% of the cells in the trachea, 27% in the large airways, and 10% in the small airways, although it is worth noting that there are differences in the compositions of the tracheobronchial epithelia between different species. Basal epithelial cells serve as the basal layer of the tracheobronchial epithelium, providing both structural and regenerative support for the epithelial tissue that lines the upper regions of the respiratory tract. They serve as progenitor or stem cells that are capable of differentiating into multiple cell types, such as ciliated and secretory cells. This gives them a central role in homeostatic maintenance of the epithelium, and in repairing damaged epithelium after an injury or during disease. This regenerative capacity is crucial in maintaining the integrity of the tracheobronchial surface, especially given its continual exposure to inhaled irritants and microorganisms. In addition to their primary restorative function, basal epithelial cells are also involved in the initial immune response within the tracheobronchial tree. Equipped with pattern recognition receptors, these cells can identify and respond to pathogenic organisms, triggering an immune response and producing a range of inflammatory mediators, such as cytokines and chemokines, to help combat infections. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "basal epithelial cell of tracheobronchial tree on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002329 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002329" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18757316" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002330 ; owl:annotatedTarget "An undifferentiated columnar cell of the bronchus epithelium" . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000154 ; owl:annotatedTarget "Any secretory cell that is capable of some protein secretion." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18757316" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002332 ; owl:annotatedTarget "A multi-ciliated epithelial cell located in the bronchus epithelium, characterized by a columnar shape and motile cilia on its apical surface." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:17507398" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002333 ; owl:annotatedTarget "An adipocyte derived from a neural crest cell." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18793119" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002334 ; owl:annotatedTarget "An undifferentiated fibroblast that can be stimulated to form a fat cell." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18719589" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002335 ; owl:annotatedTarget "A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha)." . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D009061" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002336 ; owl:annotatedTarget "An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek." . [] oboInOwl:hasDbXref "PMID:15339667", "PMID:20568222", "PMID:9520465" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002337 ; owl:annotatedTarget "A stem cell found in the basal layer of the epidermis, hair follicle, and sebaceous gland, characterised by its quiescent nature, high proliferative potential, and capacity for long-term self-renewal. This cell maintains epidermal homeostasis by producing transit-amplifying cells that differentiate to replenish the stratified squamous epithelium." . [] oboInOwl:hasDbXref "PMID:9520465" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002337 ; owl:annotatedTarget "KSC" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM853.HLFH.534" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002337 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-hair-follicle/v1.0/assets/2d-ftu-skin-hair-follicle.png" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:21907708", "PMID:30571046", "Wikipedia:Gastric_chief_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000155 ; owl:annotatedTarget "An epithelial cell of the stomach that is part of the fundic gastric gland. This cell is characterized by a basally located nucleus, abundant rough endoplasmic reticulum, and large apical secretory granules. It produces and secretes pepsinogen, the inactive precursor of the digestive enzyme pepsin." . [] oboInOwl:hasDbXref "Wikipedia:Chief_cell" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000155 ; owl:annotatedTarget "gastric chief cell" . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000031", "ISBN:0781735149", "PMID:12457618" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002338 ; owl:annotatedTarget "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-positive, CD117-positive, CD122-positive,and CD161-positive." . [] oboInOwl:hasDbXref "PMID:12457618" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002338 ; owl:annotatedTarget "p-NK" . [] oboInOwl:hasDbXref "Wikipedia:Chief_cell" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000155 ; owl:annotatedTarget "zymogenic cell" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:15226377" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002339 ; owl:annotatedTarget "A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002340 ; owl:annotatedTarget "The exocrine cell of the prostate, this epithelial cell secretes prostatic acid phosphotase and PSA, and is dependent on androgen hormones for survival." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM347.TXWZ.899" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002340 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" . [] oboInOwl:hasDbXref "GOC:tfm", "PMCID:PMC2673349" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002341 ; owl:annotatedTarget "An undifferentiated cell of the prostate epithelium that lacks secretory activity." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM347.TXWZ.899" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002341 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19652886" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002342 ; owl:annotatedTarget "A circulating endothelial cell of the phenotype CD146-positive, CD105-positive, CD45-negative. This cell type is indicative of recent vascular damage." . [] oboInOwl:hasDbXref "PMID:14568979", "PMID:19800965" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002343 ; owl:annotatedTarget "A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy." . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000031", "ISBN:0781735149", "PMID:12457618" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002344 ; owl:annotatedTarget "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." . [] oboInOwl:hasDbXref "PMID:12457618" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002344 ; owl:annotatedTarget "p-NK" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000157 ; owl:annotatedTarget obo:CL_0000151 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19949422", "http:www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002345 ; owl:annotatedTarget "An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000157 ; owl:annotatedTarget "A cell that specializes in secretion of surfactant in the alveoli of the lung." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12766763" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002346 ; owl:annotatedTarget "An immature natural killer cell that is NK1.1-positive and DX-5 negative." . [] oboInOwl:hasDbXref "DOI:10.1183/09031936.00146609", "DOI:10.1378/chest.12-2762", "GOC:tfm", "PMID:28128362", "PMID:29874100", "PMID:7905712" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000158 ; owl:annotatedTarget "A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19949422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002347 ; owl:annotatedTarget "A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:1994922" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002348 ; owl:annotatedTarget "A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000022 ; owl:annotatedTarget obo:CL_0000014 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:1994922" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002349 ; owl:annotatedTarget "A natural killer cell that is CD27-high and CD11b-low." . [] oboInOwl:hasDbXref "MESH:D020397", "http://en.wikipedia.org/wiki/Goblet_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000160 ; owl:annotatedTarget "A specialized, columnar, mucus secreting epithelial cell shaped like a flask or goblet. A narrow basal end contains the nucleus while the apical end is swollen by the accumulation of mucus laden secretory granules. Short microvilli project from the apical plasma membrane." . [] oboInOwl:hasDbXref "GOC:tfm", "ISSN:0452-3458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002350 ; owl:annotatedTarget "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." . [] oboInOwl:hasDbXref "DOI:10.1016/j.medici.2017.08.003", "DOI:10.1016/j.ydbio.2009.06.033", "DOI:10.1101/cshperspect.a036723", "DOI:10.1161/ATVBAHA.121.313788", "DOI:10.1161/CIRCRESAHA.117.312136" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002350 ; owl:annotatedTarget """Endocardial cells, often referred to as endothelial cells of the heart, constitute the innermost lining layer of the heart tissues, forming the endocardium. They play a critical role in maintaining heart functionality and homeostasis. These cells, flat and squamous in structure, are adjoined closely to form a tight barrier that separates the heart's muscular layer, the myocardium, from the blood flowing through the heart chambers. Functionally, endocardial cells are key players in several crucial physiological processes within the heart. Synthesizing matrix molecules that contribute to the structural formation of the heart, these cells actively partake in maintaining its structural integrity. They also exhibit unique metabolic activity, which aids in maintaining optimal cardiac functioning in both healthy and pathological conditions. Importantly, they are known for their involvement in modulating myocardial contraction and relaxation, that is crucial for normal heart rhythm and function. They achieve this by producing factors like nitric oxide (NO) which, amongst other things, aids in the regulation of blood pressure, prevents blood clotting and inhibits the adherence of blood cells to the vessel wall. In pathological states, endocardial cells can undergo a transformation process known as endothelial-mesenchymal transition (EndMT), which is inherently involved in several cardiac diseases. In this transition, they acquire the ability to migrate and differentiate into several other types of cells contributing to disease progression. Moreover, their dysfunction can lead to endocarditis, an inflammation of the endocardium, as well as increase the risk of other heart diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "FMA:75621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002350 ; owl:annotatedTarget "endothelial cell of endocardium" . [] a owl:Axiom ; rdfs:label "endocardial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002350 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002350" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20025937", "PMID:20217494", "PMID:22728667" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002351 ; owl:annotatedTarget "A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." . [] oboInOwl:hasDbXref "DOI:10.1016/S1357-2725(02)00083-3", "DOI:10.1038/s41575-022-00675-x", "DOI:10.1165/ajrcmb.25.5.f218", "DOI:10.1242/bio.20121701", "https://www.ncbi.nlm.nih.gov/books/NBK553208/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000160 ; owl:annotatedTarget """Goblet cells are specialized, simple columnar, secretory epithelial cells that are mostly found in the respiratory and intestinal tracts. The term \"goblet\" refers to their shape, which resembles a flask or goblet, specially at their apical end which is swollen due to the accumulation of secretory granules. The primary function of goblet cells is to to protect and lubricate the underlying tissues by secreting large quantities of mucin, a complex glycoprotein, which forms mucus when hydrated. In the respiratory tract, the mucus secreted by these cells traps dust, bacteria, viruses, and other potentially harmful particles in the inhaled air, preventing them from reaching the delicate tissues of the lungs. In the intestines, the goblet cells secrete mucus that acts as a protective barrier shielding the intestinal epithelium from dietary antigens, pathogens and prevents the intestinal epithelium from being eroded by the actions of the digestive enzymes and the abrasive action of passing food material. Goblet cells are capable of rapidly altering their secretory output in response to stimuli. For example, irritants like smoke or dust can trigger an increased rate of mucus production, as the body attempts to flush out the harmful particles. Conversely, in conditions such as chronic bronchitis and cystic fibrosis, overactive goblet cells can create a thick accumulation of mucus that obstructs the airways and fosters bacterial growth. Lastly, goblet cells are not static, rather, they undergo a dynamic process known as goblet cell metaplasia-differentiation, wherein non-goblet cells in response to chronic injury or inflammation, can differentiate into goblet cells leading to an accumulation of these cells in the tissue, known as goblet cell hyperplasia. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:978-60327-246-6" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002352 ; owl:annotatedTarget "A hematopoietic stem cell that exists during embryogenesis." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000160 ; owl:annotatedTarget "ZFA:0009094" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "goblet cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000160 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000160" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000160 ; owl:annotatedTarget "https://upload.wikimedia.org/wikipedia/commons/thumb/c/c4/404_Goblet_Cell_new.jpg/800px-404_Goblet_Cell_new.jpg" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002353 ; owl:annotatedTarget obo:CL_0002352 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:978-1-60327-346-6", "PMID:16569764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002353 ; owl:annotatedTarget "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002354 ; owl:annotatedTarget obo:CL_0002352 . [] oboInOwl:hasDbXref "GOC:tfm", "doi:10.1097/MOH.0b013e3282f97ae1" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002354 ; owl:annotatedTarget "A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "PMID:31613538", "PMID:31670611" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000162 ; owl:annotatedTarget "An epithelial cell of the stomach that is part of the fundic gastric gland. This cell is characterized by its pyramidal shape, abundant mitochondria, and a complex network of secretory canaliculi lined with microvilli. It secretes hydrochloric acid into the stomach lumen and produces intrinsic factor, essential for vitamin B12 absorption." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002355 ; owl:annotatedTarget obo:CL_0002417 . [] oboInOwl:hasDbXref "DOI:10.1097/MOH.0b013e3282f97ae1", "GOC:tfm", "PMID:11495698" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002355 ; owl:annotatedTarget "A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000022 ; owl:annotatedTarget obo:CL_0000021 . [] oboInOwl:hasDbXref "PMID:29263912" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000162 ; owl:annotatedTarget "gastric parietal cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002356 ; owl:annotatedTarget obo:CL_0002417 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:11495698", "doi:10.1097/MOH.0b013e3282f97ae1" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002356 ; owl:annotatedTarget "A primitive erythrocyte that has undergone enucleation. This cell type is 3-6 fold bigger than the fetal derived erythrocytes that they co-circulate with during fetal development. Expresses epsilon-gamma hemoglobin chains." . [] oboInOwl:hasDbXref "Wikipedia:Parietal_cell" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000162 ; owl:annotatedTarget "oxyntic cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002357 ; owl:annotatedTarget obo:CL_0000595 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:11495698" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002357 ; owl:annotatedTarget "A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins." . [] oboInOwl:hasDbXref "PMID:29263912", "PMID:31613538" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0000162 ; owl:annotatedTarget "Parietal cells have dynamic, actin-supported microvilli that increase in number during active secretion, playing a crucial role in secreting hydrochloric acid and intrinsic factor. The structure and regulation of these microvilli are influenced by proteins such as ASAP3, which modulates Arf6 activity and actin assembly, thereby controlling microvilli formation and parietal cell function." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002358 ; owl:annotatedTarget obo:CL_0002417 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002358 ; owl:annotatedTarget "Derived from the Greek word pyren (the pit of a stone fruit), this is a transient nucleated cell type that results from exclusion of the nucleus from the primitive erythrocyte." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:978-1-60327-346-6" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002359 ; owl:annotatedTarget "A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:978-1-60327-346-6" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002360 ; owl:annotatedTarget "A hematopoietic stem cell from the aorta-gonad-mesonephros region of the developing embryo. First seen at E10.5 in mouse embryos. May give rise to fetal liver HSC." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002361 ; owl:annotatedTarget obo:CL_0002417 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0813817986", "PMID:20711979" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002361 ; owl:annotatedTarget "A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:14745007" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002362 ; owl:annotatedTarget "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive." . [] oboInOwl:hasDbXref "doi:10.3389/fncir.2020.611841" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0002362 ; owl:annotatedTarget "granule cell precursor" . [] oboInOwl:hasDbXref "doi:10.3389/fncir.2020.611841" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0002362 ; owl:annotatedTarget "granule cell progenitor" . [] oboInOwl:hasDbXref "doi:10.3389/fncir.2020.611841" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002362 ; owl:annotatedTarget "GCP" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:9780702029585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002363 ; owl:annotatedTarget "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18403190" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002364 ; owl:annotatedTarget "An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells." . [] oboInOwl:hasDbXref "DOI:10.1016/bs.ai.2014.09.003", "DOI:10.1038/nri3667", "DOI:10.1111/sji.13094" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002364 ; owl:annotatedTarget """Cortical thymic epithelial cells (cTECs) are a vital cell type located in the thymus, a lymphoid organ that plays a key role in the development of T cells, which are essential for the adaptive immune system. cTECs also have a role in forming barriers and lining surfaces. In the thymus, their presence contributes to the distinctive architecture of both the cortex and medulla. cTECs also play a significant part in the selection and development of T cells. During T cell maturation, these cells express both self and non-self proteins via the major histocompatibility complex (MHC) to immature T cells. cTECs then stimulate the T cells that can recognize such proteins, an important event known as positive selection. This process aids in the creation of a diverse T cell receptor (TCR) repertoire that can react to a wide range of antigens, therefore ensuring effective immunity. Apart from aiding in T cells' positive selection, cTECs also contribute to eliminating self-reactive T cells, a role essential in preventing autoimmune diseases. These cells induce an apoptosis-driven process known as \"negative selection\" which eliminates T cells that are too highly reactive to self-antigens. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "cortical thymic epithelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002364 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002364" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18180458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002365 ; owl:annotatedTarget "An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output." . [] oboInOwl:hasDbXref "DOI:10.1007/s11427-013-4482-4", "DOI:10.4049/jimmunol.2100692", "DOI:10.7554/eLife.60188" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002365 ; owl:annotatedTarget """Medullary thymic epithelial cells (mTECs) are distinct cells situated in the thymic medulla, a vital organ where T cells mature. mTECs are recognized by their unique appearance, characterized by large, plump cells with abundant cytoplasm and irregularly shaped nuclei. They inhabit a microenvironment closely interacting with various thymic cell types, including conventional dendritic cells and thymocytes. The primary function of mTECs revolves around negative selection of developing T cells, thus preventing autoimmune responses. mTECs allow developing T cells to recognize and be responsive to foreign antigens while remaining tolerant to the body's own tissues. They achieve this through a process called promiscuous gene expression where they express and display a vast array of self-antigens. This process is regulated by a transcriptional regulator called autoimmune regulator (Aire), which contributes to immunological self-tolerance. mTECs themselves have a self-renewing ability and sustain the continuous export of mature T cells. They also express a number of genes that encode for chemokines and other signaling molecules which draw in and retain developing T cells for the process of negative selection. The three-dimensional network formed by these cells provides a physical platform for such selection. Together, mTECs hold a critical place in the maintenance of immune homeostasis, demonstrating the conceptual links that exist between population of stromal cells, thymocytes development, tissue-restricted antigen expression, and negative selection. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "medullary thymic epithelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002365 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002365" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM322.LZLG.752" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002365 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:11429640" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002366 ; owl:annotatedTarget "A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin." . [] oboInOwl:hasDbXref "DOI:10.1073/pnas.070447210", "DOI:10.1093/humupd/dmr031", "DOI:10.1177/1535370220938741", "https://www.sciencedirect.com/topics/medicine-and-dentistry/uterine-contraction", "https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/myometrium" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002366 ; owl:annotatedTarget """Myometrial cells are specialized smooth muscle cells located in the myometrium, the middle layer of the uterine wall. Unique to female reproductive physiology, they play a key role in pregnancy and childbirth. These cells are distinctive in their capability to substantially increase in size and number during pregnancy, preparing the uterus to accommodate the growing fetus. As pregnancy progresses, myometrial cells demonstrate a progressive growth in uterine mass through cellular hypertrophy. They are also responsible for the production of extracellular matrix proteins like collagen, which aids in supporting cell structure and function, further facilitating uterine enlargement. During childbirth, myometrial cells are responsible for the expansion and contraction of the uterus. They can propagate action potentials and generate considerable force, which is critical to their function in the reproductive system. After pregnancy, these cells can reduce in size, a process known as uterine involution. Given the important role these cells play in female reproductive physiology, dysregulation of the myometrial cell function can contribute to uterine pathologies such as uterine fibroids. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "myometrial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002366 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002366" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002367 ; owl:annotatedTarget obo:CL_0000115 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:14500801" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002367 ; owl:annotatedTarget "A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002368 ; owl:annotatedTarget "An epithelial cell of the respiratory tract epithelium. These cells have an endodermal origin." . [] oboInOwl:hasDbXref "FAO:0000019", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002369 ; owl:annotatedTarget "A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002370 ; owl:annotatedTarget "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion." . [] oboInOwl:hasDbXref "DOI:10.1016/S1357-2725(02)00083-3", "DOI:10.1111/febs.15731", "DOI:10.1165/ajrcmb.25.5.f218", "DOI:10.2147/COPD.S38938", "DOI:10.3109/01902148.2013.791733" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002370 ; owl:annotatedTarget """The respiratory goblet cell is a highly specialized cell type found primarily within the respiratory tract, including the nose, trachea, and lungs. Named because their shape resembles a goblet - a drinking vessel with a wide body and narrow neck - these cells form a vital part of the respiratory system's protective mechanisms. They are found within the columnar epithelium lining these organs, which forms a barrier between the internal body and the exterior environment. A principal function of the respiratory goblet cell is the production and secretion of mucus, a carbohydrate-rich, viscous and gel-like substance that plays a critical role in trapping dust, bacteria, viruses, and other airborne particles that are inhaled. The mucus secreted by the goblet cells covers the lining of the respiratory tract, effectively catching these particles and preventing them from reaching the lungs and causing infection. Mucus also provides hydration and lubrication to the respiratory tract surfaces, which is important in maintaining the tissue's health and functioning. In addition to their mucus-secreting capabilities, respiratory goblet cells also play a significant role in the body's inflammatory responses. When the respiratory system is exposed to irritants or pathogens, the number and activity of goblet cells often increase, leading to a higher production of mucus. This is a protective response designed to trap and neutralize the harmful substances more effectively. However, in conditions like chronic obstructive pulmonary disease (COPD) and asthma, an overproliferation of goblet cells, also known as goblet cell hyperplasia, can lead to excessive mucus production and airway obstruction. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "MP:0010863" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002370 ; owl:annotatedTarget "respiratory mucosa goblet cells" . [] a owl:Axiom ; rdfs:label "respiratory tract goblet cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002370 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002370" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002371 ; owl:annotatedTarget "OBSOLETE. A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell)." . [] oboInOwl:hasDbXref "DOI:10.1038/nrm3980", "https://www.genome.gov/genetics-glossary/Somatic-Cells", "https://www.ncbi.nlm.nih.gov/books/NBK557896/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002371 ; owl:annotatedTarget """Somatic cells represent the majority of the cell types in the human body. They are fundamental building blocks of organs, tissues, and other bodily structures, with every organ being composed of distinct subpopulations of these cells. The primary function of somatic cells is to maintain the function and survival of an organism. They carry significant information in the form of DNA, and through the process of mitosis, contribute to the repair and regeneration of body tissues. Further, some types of somatic cells work in a collaborative manner to form complex functional structures such as the skin and lining of the gut, demonstrating a higher level of organization. However, it's important to note that somatic cells are distinct from germ cells, which are responsible for sexual reproduction by forming sperm or eggs. Any alterations in the DNA of somatic cells, due to mutations, will not affect the offspring as they aren't involved in transmission of genetic information to the next generation. While most somatic cells contain two copies of each chromosome (diploid), a certain subset may possess a single set of chromosomes (haploid), specifically found in male ants, bees, and other hymenopterans. Hence, diversity is a defining characteristic of somatic cells, reflecting in their structures, roles, and genetic makeup. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "obsolete somatic cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002371 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002371" . [] oboInOwl:hasDbXref "doi:10.1016/j.stem.2012.05.016" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000022 ; owl:annotatedTarget "A stem cell that is the precursor of female gametes." . [] oboInOwl:hasDbXref "GOC:dos", "GOC:tfm", "ISBN:0323052908", "PMID:22274696" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002372 ; owl:annotatedTarget "A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0002372 ; owl:annotatedTarget "FBbt:00005812" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FBbt:00005812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002372 ; owl:annotatedTarget "myofiber" . [] oboInOwl:hasDbXref "FBbt:00005812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002372 ; owl:annotatedTarget "myofibril" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002373 ; owl:annotatedTarget "A peptide hormone secreting cell that secretes growth hormone releasing hormone." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tfm", "ISBN:0192801023" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002374 ; owl:annotatedTarget "A hair cell of the ear that contains the organs of balance and hearing." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:15580626", "PMID:30971890", "PMID:35815410" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002375 ; owl:annotatedTarget "A multipotent progenitor cell that develops from a migratory neural crest cell. The schwann cell precursor is embedded among axons, with minimal extracellular space separating them from nerve cell membranes. This cell lacks a basal lamina, which distinguishes it from more mature Schwann cells. In rodents, cadherin-19 (Cdh19) serves as a specific marker for this developmental stage." . [] oboInOwl:hasDbXref "PMID:35815410" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002375 ; owl:annotatedTarget "SCP" . [] oboInOwl:hasDbXref "PMID:35815410" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002375 ; owl:annotatedTarget "Schwann cell precursor are capable of differentiating into Schwann cells and other cell types such as melanocytes, neurons, and mesenchymal cells." . [] oboInOwl:hasDbXref "GOC:cvs", "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002376 ; owl:annotatedTarget "A glial cell that ensheaths multiple small diameter axons in the peripheral nervous system. The non-myelinating Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. These cells can de-differentiate into immature Schwann cells." . [] oboInOwl:hasDbXref "GOC:cvs", "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002377 ; owl:annotatedTarget "A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0002377 ; owl:annotatedTarget "ZFA:0001725" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002378 ; owl:annotatedTarget "A double negative thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive and is found in the fetal thymus." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.aippg.net/forum/viewtopic.php?t=62590" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002379 ; owl:annotatedTarget "A neurecto-epithelial cell found in the arachnoid villi of dura mater. This cell type facilitates flow of cerebrospinal fluid into the blood." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0851988857", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002380 ; owl:annotatedTarget "An asexual spore formed by Oomycetes; formed upon fertilization of an oosphere." . [] oboInOwl:hasDbXref "GOC:tfm", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002381 ; owl:annotatedTarget "A conidium that has only one nucleus." . [] oboInOwl:hasDbXref "GOC:tfm", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002382 ; owl:annotatedTarget "A conidium that has more than one nucleus." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:9529886", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002383 ; owl:annotatedTarget "A uninucleate spore formed on specialized cells or projections, sterigma, of a conidiophore head." . [] oboInOwl:hasDbXref "GOC:tfm", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002384 ; owl:annotatedTarget "A macroconidium that has only one nucleus." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:2524423", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002385 ; owl:annotatedTarget "An oblong or round asexual spore formed from conidial chains." . [] oboInOwl:hasDbXref "GOC:tfm", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002386 ; owl:annotatedTarget "A macroconidium that has more than one nucleus." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:2524423", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002387 ; owl:annotatedTarget "Cylindrical spore formed by development and compartmentation of hyphae; the hyphae are often supporting blastoconidiophores." . [] oboInOwl:hasDbXref "GOC:tfm", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002388 ; owl:annotatedTarget "An arthroconidium that has more than one nucleus." . [] oboInOwl:hasDbXref "GOC:tfm", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002389 ; owl:annotatedTarget "An arthroconidium that has only one nucleus." . [] oboInOwl:hasDbXref "GOC:tfm", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002390 ; owl:annotatedTarget "A blastoconidium that has only one nucleus." . [] oboInOwl:hasDbXref "GOC:tfm", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002391 ; owl:annotatedTarget "A blastoconidium that has more than one nucleus." . [] oboInOwl:hasDbXref "GOC:tfm", "PO:0025017" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002392 ; owl:annotatedTarget "Obsolete. Use PO:0025017 from Plant Ontology instead. A plant cell that arises through meiosis and develops into a gametophyte." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20628149", "PMID:20870168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002393 ; owl:annotatedTarget "A monocyte that has characteristics of both patrolling and inflammatory monocytes." . [] oboInOwl:hasDbXref "MESH:D055098" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000163 ; owl:annotatedTarget "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002394 ; owl:annotatedTarget obo:CL_0000782 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "PMCID:PMC2882828", "PMCID:PMC2882837", "PMID:17332250", "PMID:20628149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002394 ; owl:annotatedTarget "A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000163 ; owl:annotatedTarget "ZFA:0009096" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000164 ; owl:annotatedTarget "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002395 ; owl:annotatedTarget obo:CL_0000860 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20628149", "PMID:8890901", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002395 ; owl:annotatedTarget "A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000022 ; owl:annotatedTarget "FBbt:00004873" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "DOI:10.1038/s41574-019-0168-8", "DOI:10.1111/j.1463-1326.2011.01438.x", "DOI:10.1196/annals.1294.001", "DOI:10.1210/endrev/bnaa018", "DOI:10.7554/elife.78512" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000164 ; owl:annotatedTarget """Enteroendocrine cells are a specialized subset of cells located within the epithelial lining of both the small and large intestines, as well as the stomach and pancreas. Constituting less than 1% of the total population of intestinal cells, they are differentiated from a common intestinal cell progenitor, thus sharing lineage with absorptive and goblet cells of the intestines. The distinct characteristic feature of an enteroendocrine cell is its inherent capacity to synthesize and secrete a plethora of gut hormones such as serotonin, somatostatin, neurotensin, cholecystokinin, secretin, gastric inhibitory peptide, motilin, and glucagon-like peptide-1. Integrated within this complex network of signaling agents, these substances control various aspects of the digestive system. Each enteroendocrine cell has its unique combination of hormones to release, determined by its position along the intestinal tract. Intriguingly, these hormones not only modulate local gut function, including motility, absorption and secretion, but also potentiate distant actions on other systems such as endocrine, nervous and immune and play a role in the feeling of satiety. The release of these hormones from enteroendocrine cells is a highly regulated and dynamic process. The cells are equipped with sensory receptors localized on its luminal side that respond to various stimuli, including changes in nutrient composition, chemical or mechanical changes in the gut lumen, or even signals arising from commensal microbiota. This sensory input stimulates a signaling cascade within the cell, culminating in the release of specific hormones into the interstitial fluid. These hormones then make their way into the bloodstream, acting on their respective target receptors to mediate their duties. The multifunctional characteristics of enteroendocrine cells make them crucial for maintaining gut homeostasis and the overall physiological well being of the body. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002396 ; owl:annotatedTarget obo:CL_0000875 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20870168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002396 ; owl:annotatedTarget "A patrolling monocyte that is CD14-low and CD16-positive." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000164 ; owl:annotatedTarget "ZFA:0009097" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20628149", "PMID:21937707", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002397 ; owl:annotatedTarget "A CD14-positive monocyte that is also CD16-positive and CCR2-negative." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002397 ; owl:annotatedTarget "CD16+ monocyte" . [] a owl:Axiom ; rdfs:label "enteroendocrine cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000164 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000164" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20628149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002398 ; owl:annotatedTarget "An intermediate monocyte that is Gr1-positive, CD43-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002399 ; owl:annotatedTarget obo:CL_0000782 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "PMID:20204387", "PMID:20628149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002399 ; owl:annotatedTarget "A myeloid dendritic cell that is CD1c-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002400 ; owl:annotatedTarget obo:CL_0000817 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002400 ; owl:annotatedTarget "A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002401 ; owl:annotatedTarget "A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." . [] oboInOwl:hasDbXref "MESH:D055099" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000165 ; owl:annotatedTarget "A neuron that is capable of some hormone secretion in response to neuronal signals." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000165 ; owl:annotatedTarget "FBbt:00005130" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002402 ; owl:annotatedTarget "A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002403 ; owl:annotatedTarget "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002404 ; owl:annotatedTarget "A thymocyte found in the fetal thymus." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000165 ; owl:annotatedTarget "ZFA:0009098" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20725107" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002405 ; owl:annotatedTarget "A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative)." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002406 ; owl:annotatedTarget "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive." . [] oboInOwl:hasDbXref "PMID:5342440", "https://www.clinicalkey.com/#!/content/book/3-s2.0-B9780323555968000073" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0000165 ; owl:annotatedTarget """The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. The modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron.""" . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002407 ; owl:annotatedTarget "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002408 ; owl:annotatedTarget "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain that does not contain a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002409 ; owl:annotatedTarget "A thymocyte that has a T cell receptor consisting of a gamma chain that does not contain the Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative." . [] oboInOwl:hasDbXref "GOC:mah", "GOC:tfm", "PMID:17200706" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002410 ; owl:annotatedTarget "A cell that is found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and has long cytoplasmic processes that encircle the base of the acinus. Expresses several intermediate filament proteins including vimentin and nestin. Shares many of the characteristics of hepatatic stellate cells, but not stellate cells of the central nervous system. Upon activation, this cell type undergoes morphological and gene expression changes that make the cell suggestive of being a type of myofibroblast." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002411 ; owl:annotatedTarget "A gamma-delta receptor that expresses Vgamma1.1 but does not express Vdelta6.3 chains in the T-cell receptor." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002412 ; owl:annotatedTarget "A gamma-delta receptor that expresses Vgamma1.1-Vdelta6.3 chains in the T-cell receptor." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002413 ; owl:annotatedTarget "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-negative." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002414 ; owl:annotatedTarget "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-positive." . [] oboInOwl:hasDbXref "MESH:D019439" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000166 ; owl:annotatedTarget "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002415 ; owl:annotatedTarget "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-positive." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002416 ; owl:annotatedTarget "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-negative." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002417 ; owl:annotatedTarget "An immature or mature cell of the first erythroid lineage to arise during embryonic development." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0813817986", "PMID:11495698" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002418 ; owl:annotatedTarget "A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells." . [] oboInOwl:hasDbXref "DOI:10.1002/cphy.c190003", "DOI:10.1016/j.biocel.2016.02.003", "DOI:10.3389/fendo.2018.00711", "DOI:10.3389/fimmu.2022.977175", "DOI:10.3389/fimmu.2022.977175/full" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000166 ; owl:annotatedTarget """Chromaffin cells, also known as pheochromocytes, are neuroendocrine cells that are typically located in the adrenal medulla, the innermost part of the adrenal gland, which is situated on top of each kidney. Chromaffin cells are also found in small clusters, known as paraganglia, in various locations throughout the body, including the sympathetic nervous system. They derive their name from their ability to stain a brownish-black color upon exposure to chromic salts, a feature made possible due to their high content of granules rich in catecholamines and catecholamine-related neurotransmitters. The primary function of chromaffin cells is the synthesis and release of catecholamines, specifically epinephrine (adrenaline) and norepinephrine (noradrenaline). These neurotransmitters are vital stress hormones that, when released by the adrenal chromaffing cells into the bloodstream, prepare the body for the 'fight or flight' response. This response can enhance the body's performance in a dangerous situation by increasing heart rate, elevating blood sugar, and increasing blood flow to the muscles. The chromaffin cells in paraganglia are responsible for the local release of catecholamines and play a role in regulating blood pressure and other autonomic functions. In addition to their role in stress response, chromaffin cells also contribute to the body's immune response. They secrete several peptides including antimicrobial peptides, and the discovery of LPS and cytokine receptors on chromaffin cells suggests that the adrenal medulla may participate in some aspects of the immune response. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002419 ; owl:annotatedTarget obo:CL_0000084 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002419 ; owl:annotatedTarget "A T cell that expresses a T cell receptor complex and has completed T cell selection." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000166 ; owl:annotatedTarget "ZFA:0009099" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002420 ; owl:annotatedTarget obo:CL_0000084 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002420 ; owl:annotatedTarget "A T cell that has not completed T cell selection." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002421 ; owl:annotatedTarget obo:CL_0000558 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18182572", "PMID:9011180", "PMID:9046052" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002421 ; owl:annotatedTarget "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." . [] a owl:Axiom ; rdfs:label "chromaffin cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000166 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000166" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002422 ; owl:annotatedTarget obo:CL_0000558 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0-12203-052-4", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002422 ; owl:annotatedTarget "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002423 ; owl:annotatedTarget obo:CL_0000806 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20595614" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002423 ; owl:annotatedTarget "A DN2 thymocyte that is Kit-hi." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002424 ; owl:annotatedTarget obo:CL_0000806 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20595614" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002424 ; owl:annotatedTarget "A DN2 thymocyte that is Kit-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002425 ; owl:annotatedTarget obo:CL_0000827 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "PMID:16551251", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002425 ; owl:annotatedTarget "A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002426 ; owl:annotatedTarget "A mature natural killer cell that is CD11b-positive and CD27-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002427 ; owl:annotatedTarget obo:CL_0000809 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002427 ; owl:annotatedTarget "A double-positive, alpha-beta thymocyte that is small and not proliferating." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000023 ; owl:annotatedTarget obo:CL_0000021 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000167 ; owl:annotatedTarget "Any secretory cell that is capable of some peptide hormone secretion." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002428 ; owl:annotatedTarget obo:CL_0000809 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002428 ; owl:annotatedTarget "A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000167 ; owl:annotatedTarget "ZFA:0009100" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002429 ; owl:annotatedTarget obo:CL_0000809 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002429 ; owl:annotatedTarget "A double-positive thymocyte that is CD69-positive and has begun positive selection." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002430 ; owl:annotatedTarget obo:CL_0000809 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002430 ; owl:annotatedTarget "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002431 ; owl:annotatedTarget obo:CL_0000809 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002431 ; owl:annotatedTarget "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD8 co-receptor." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002432 ; owl:annotatedTarget obo:CL_0000810 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002432 ; owl:annotatedTarget "A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000168 ; owl:annotatedTarget "Any secretory cell that is capable of some insulin secretion." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002433 ; owl:annotatedTarget obo:CL_0000810 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002433 ; owl:annotatedTarget "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000168 ; owl:annotatedTarget "ZFA:0009101" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002434 ; owl:annotatedTarget obo:CL_0000811 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002434 ; owl:annotatedTarget "A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002435 ; owl:annotatedTarget obo:CL_0000811 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html", "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002435 ; owl:annotatedTarget "A CD8-positive, CD4-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000023 ; owl:annotatedTarget "A female germ cell that has entered meiosis." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002436 ; owl:annotatedTarget obo:CL_0000624 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002436 ; owl:annotatedTarget "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002436 ; owl:annotatedTarget "T.4SP24-.Th" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002437 ; owl:annotatedTarget obo:CL_0000625 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002437 ; owl:annotatedTarget "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002438 ; owl:annotatedTarget "A mature NK cell that is NK1.1-positive." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002439 ; owl:annotatedTarget "A NK1.1-positive T cell that is NKGA2-positive." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002440 ; owl:annotatedTarget "A NK1.1-positive T cell that is Ly49D-positive." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002441 ; owl:annotatedTarget "A NK1.1-positive T cell that is CD94-positive." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002442 ; owl:annotatedTarget "A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget obo:CL_0000168 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002443 ; owl:annotatedTarget "A NK1.1-positive T cell that is Ly49Cl-positive." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "http://en.wikipedia.org/wiki/Pancreatic_b_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "A cell that secretes insulin and is located towards the center of the islets of Langerhans." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002444 ; owl:annotatedTarget "A NK1.1-positive T cell that is Ly49H-positive." . [] oboInOwl:hasDbXref "ZFA:0009102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "beta cell" . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002445 ; owl:annotatedTarget "A NK1.1-positive T cell that is Ly49D-negative." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002446 ; owl:annotatedTarget "A NK1.1-positive T cell that is Ly49Cl-negative." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000023 ; owl:annotatedTarget "FBbt:00004886" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "ZFA:0009102" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002447 ; owl:annotatedTarget "A NK1.1-positive T cell that is CD94-negative." . (obo:CL_0002438 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000009623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_10090 ] ) . [] oboInOwl:hasDbXref "FMA:70586" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "B-cell of pancreatic islet" . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002448 ; owl:annotatedTarget "A NK1.1-positive T cell that is Ly49H-negative." . [] oboInOwl:hasDbXref "FMA:70586" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "beta cell of pancreatic islet" . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002449 ; owl:annotatedTarget "A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive." . [] oboInOwl:hasDbXref "GOC:cvs", "GOC:tfm", "PMID:9398434" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002450 ; owl:annotatedTarget "A specialized hair cell that has an elongated kinocilium upon which an otolith accretes. The tether cell then anchors the otolith in place." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0002450 ; owl:annotatedTarget "ZFA:0005565" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:hjd", "GOC:tfm", "PMID:15987436", "PMID:16397499", "PMID:17851544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002451 ; owl:annotatedTarget "A multi-fate stem cell that is the source of cells for growth of the mammary gland during puberty and gestation. This cell type gives rise to both the luminal and myoepithelial cell types of the gland, and have been shown to have the ability to regenerate the entire organ in mice. This cell type also plays an important role in carcinogenesis of the breast. This cell type is Lin-, CD24-positive, CD29-hi." . [] oboInOwl:hasDbXref "FMA:70586" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "insulin-secreting cell" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:16367798", "PMID:20142420", "PMID:31583586", "PMID:31726662", "PMID:37653126" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002453 ; owl:annotatedTarget "A proliferative and migratory glial progenitor cell that derives from a neural stem cell and resides within the central nervous system. It possesses the capacity to differentiate into a committed oligodendrocyte progenitor (COP) through a well-defined series of maturation steps, ultimately giving rise to a myelinating oligodendrocyte (MOL). In mice and humans, it is characterized by the expression of specific molecular markers, including Pdgfra, Cspg4 (also known as NG2) and Olig2." . [] oboInOwl:hasDbXref "ISBN:9780702028991", "PMID:10704434", "PMID:2182078" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002453 ; owl:annotatedTarget "This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991)." . [] oboInOwl:hasDbXref "PMID:14501223" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002453 ; owl:annotatedTarget "NG2 cell" . [] oboInOwl:hasDbXref "PMID:2182078" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002453 ; owl:annotatedTarget "O2-A" . [] oboInOwl:hasDbXref "PMID:14501223" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002453 ; owl:annotatedTarget "OPC" . [] oboInOwl:hasDbXref "PMID:23516142" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002453 ; owl:annotatedTarget "Polydendrocyte" . [] oboInOwl:hasDbXref "FMA:70586" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "pancreatic B-cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002454 ; owl:annotatedTarget obo:CL_0002465 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002454 ; owl:annotatedTarget "CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8-alpha-negative and is CD205-positive." . [] oboInOwl:hasDbXref "FMA:70586" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "pancreatic beta cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002455 ; owl:annotatedTarget obo:CL_0000989 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002455 ; owl:annotatedTarget "A CD11c-low plasmacytoid dendritic cell that is CD8-alpha-negative and CD4-positive." . [] oboInOwl:hasDbXref "MA:0002419" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "pancreatic islet core" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002456 ; owl:annotatedTarget obo:CL_0000989 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002456 ; owl:annotatedTarget "A CD11c-low plasmacytoid dendritic cell that is CD8-alpha-positive and CD4-positive." . [] oboInOwl:hasDbXref "FMA:70586" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "type B enteroendocrine cell" . [] oboInOwl:hasDbXref "MA:0002419" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "beta cell islet" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002457 ; owl:annotatedTarget obo:CL_0000453 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002457 ; owl:annotatedTarget "A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM642.BMZS.772" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002457 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-epidermal-ridge/v1.2/assets/2d-ftu-skin-epidermal-ridge.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002458 ; owl:annotatedTarget obo:CL_0001006 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002458 ; owl:annotatedTarget "A dermal dendritic cell that is langerin-positive and CD103-positive." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM637.SFSW.654" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-islets-langerhans/v1.2/assets/2d-ftu-pancreas-islets-langerhans.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002459 ; owl:annotatedTarget obo:CL_0001006 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002459 ; owl:annotatedTarget "A dermal dendritic cell that is langerin-negative, CD103-negative, and CD11b-positive." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000023 ; owl:annotatedTarget "ZFA:0001109" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002460 ; owl:annotatedTarget obo:CL_0000941 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19273629", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002460 ; owl:annotatedTarget "A conventional thymic dendritic cell that is CD8-alpha-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002461 ; owl:annotatedTarget obo:CL_0000990 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002461 ; owl:annotatedTarget "A conventional dendritic cell that is CD103-positive. This cell type is usually found in non-lymphoid tissue." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002462 ; owl:annotatedTarget obo:CL_0000990 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002462 ; owl:annotatedTarget "A F4/80-negative dendritic cell located in adipose tissue." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002463 ; owl:annotatedTarget "An adipose dendritic cell that is SIRPa-positive." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002464 ; owl:annotatedTarget "An adipose dendritic cell that is SIRPa-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002465 ; owl:annotatedTarget obo:CL_0000990 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002465 ; owl:annotatedTarget "A conventional dendritic cell that expresses CD11b (ITGAM)." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000170 ; owl:annotatedTarget "A cell that secretes glucagon." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002466 ; owl:annotatedTarget obo:CL_0002465 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002466 ; owl:annotatedTarget "A CD11b-positive dendritic cell located in the serosal portion of the small intestine epithelium. This cell type is CD45-positive, MHC-II-positive, CD11c-low, CD103-negative." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000170 ; owl:annotatedTarget "ZFA:0009103" ; sssom:mapping_justification . [] dc:license "http://creativecommons.org/licenses/by/4.0/" ; oboInOwl:hasDbXref "doi:10.1186/s13619-020-00061-5" ; a owl:Axiom ; rdfs:comment """Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer). ISC: Intestinal Stem Cell TA: Transit Amplifying Cells""" ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002466 ; owl:annotatedTarget . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002467 ; owl:annotatedTarget obo:CL_0000889 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002467 ; owl:annotatedTarget "A myeloid suppressor cell that is Gr1-high and CD11c-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002468 ; owl:annotatedTarget obo:CL_0000889 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002468 ; owl:annotatedTarget "A myeloid suppressor cell that is Gr1-low and CD11c-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002469 ; owl:annotatedTarget obo:CL_0002395 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002469 ; owl:annotatedTarget "Gr1-high monocyte that lacks MHC-II receptor complex." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002470 ; owl:annotatedTarget obo:CL_0002395 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002470 ; owl:annotatedTarget "Gr1-high monocyte that has a MHC-II receptor complex." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002471 ; owl:annotatedTarget obo:CL_0002058 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002471 ; owl:annotatedTarget "Gr1-low non-classical monocyte that lacks expression of a MHC-II complex." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002472 ; owl:annotatedTarget obo:CL_0002058 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002472 ; owl:annotatedTarget "Gr1-low non-classical monocyte that has low to intermediate expression of the MHC-II complex." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002473 ; owl:annotatedTarget obo:CL_0002058 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002473 ; owl:annotatedTarget "Gr1-low non-classical monocyte that has high surface expression of a MHC-II complex." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002474 ; owl:annotatedTarget obo:CL_0002469 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002474 ; owl:annotatedTarget "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000171 ; owl:annotatedTarget "A type A enteroendocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000171 ; owl:annotatedTarget "ZFA:0009104" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002475 ; owl:annotatedTarget "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-intermediate, and CD11b-high." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM637.SFSW.654" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000171 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-islets-langerhans/v1.2/assets/2d-ftu-pancreas-islets-langerhans.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002476 ; owl:annotatedTarget obo:CL_0000864 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002476 ; owl:annotatedTarget "A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive." . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002476 ; owl:annotatedTarget "MF.BM" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002477 ; owl:annotatedTarget obo:CL_0000864 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002477 ; owl:annotatedTarget "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002478 ; owl:annotatedTarget obo:CL_0002477 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002478 ; owl:annotatedTarget "An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002479 ; owl:annotatedTarget obo:CL_0002477 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002479 ; owl:annotatedTarget "An adipose macrophage that does not express MHC-II but is F4/80-positive." . [] oboInOwl:hasDbXref "GOC:cjm", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002480 ; owl:annotatedTarget "A goblet cell located in the nasal epithelium." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002480 ; owl:annotatedTarget "The marker set LYPD2, MUC5AC can identify the Human cell type nasal mucosa goblet cell in the lung with a confidence of 0.81 (NS-Forest FBeta value)." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002481 ; owl:annotatedTarget obo:CL_0000185 . [] oboInOwl:hasDbXref "GOC:cjm", "GOC:tfm", "MP:0006420" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002481 ; owl:annotatedTarget "The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000172 ; owl:annotatedTarget "Any secretory cell that is capable of some somatostatin secretion." . [] oboInOwl:hasDbXref "GOC:cjm", "GOC:tfm", "MP:0009386" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002482 ; owl:annotatedTarget "A melanocyte that produces pigment in the dermis." . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0004381" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002483 ; owl:annotatedTarget "A melanocyte that produces pigment within the hair follicle." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM853.HLFH.534" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002483 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-hair-follicle/v1.0/assets/2d-ftu-skin-hair-follicle.png" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000172 ; owl:annotatedTarget "ZFA:0009105" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002484 ; owl:annotatedTarget obo:CL_0000148 . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0009388" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002484 ; owl:annotatedTarget "A melanocyte that produces pigment in the epithelium." . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0010190" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002485 ; owl:annotatedTarget "A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium." . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0000048" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002486 ; owl:annotatedTarget "A melanocyte located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) ." . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0000973" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002487 ; owl:annotatedTarget "A neuronal receptor that respond to mechanical pressure or distortion in the skin." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002488 ; owl:annotatedTarget obo:CL_0000351 . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0001714", "MP:19876834" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002488 ; owl:annotatedTarget "A trophoblast cell that has a large volume of cytoplasm, is polyploid and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta." . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0002407" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002489 ; owl:annotatedTarget "A thymocyte that lacks expression of CD4 and CD8." . [] oboInOwl:hasDbXref "MP:0002407" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002489 ; owl:annotatedTarget "CD4-CD8- T cell" . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0004300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002490 ; owl:annotatedTarget "A supporting cell of the organ of Corti." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002491 ; owl:annotatedTarget "A specialized cell involved in auditory sensory perception." . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0004366" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002492 ; owl:annotatedTarget "A polarized columnar cell that covesr the lateral surface of the cochlear duct, secretes potassium ions and forms a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria." . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0004365" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002493 ; owl:annotatedTarget "A polarized cell that is juxtaposed to fibrocytes in the underlying spiral ligament. This cell type secretes potassium ions derived from fibrocytes through gap junctions." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002494 ; owl:annotatedTarget "A cell located in the heart, including both muscle and non muscle cells." . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0008788" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002495 ; owl:annotatedTarget "A fetal and neonatal heart cell that undergoes proliferation and is not yet terminally differentiated into a binucleate or a multinucleate cardiac myocyte." . [] oboInOwl:hasDbXref "FMA:0517223651", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000173 ; owl:annotatedTarget "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002496 ; owl:annotatedTarget obo:CL_0002419 . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0008894" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002496 ; owl:annotatedTarget "A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response." . [] oboInOwl:hasDbXref "GOC:tfm", "PMCID:PMC85124" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002497 ; owl:annotatedTarget "A trophoblast giant cell derived from the mural trophectoderm." . [] oboInOwl:hasDbXref "GOC:tfm", "PMCID:PMC85124" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002498 ; owl:annotatedTarget "A trophoblast giant cell that is derived from ectoplacental cone and, later in gestation, the spongiotrophoblast." . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0008959" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002499 ; owl:annotatedTarget "A trophoblast cell that arises in the junctional zone (basal plate) of the placenta." . [] oboInOwl:hasDbXref "FMA:63418", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002500 ; owl:annotatedTarget "A P/D1 enteroendocrine cell that is Grimelius positive and stores bombesin-like polypeptide." . [] oboInOwl:hasDbXref "FMA:63207", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002501 ; owl:annotatedTarget "A P/D1 enteroendocrine cell that is argyrophilic and stores vasoactive intestinal polypeptide." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:15153415" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002502 ; owl:annotatedTarget "An enteroendocrine cell of the small intestine that secretes motilin." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000173 ; owl:annotatedTarget "ZFA:0005743" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002503 ; owl:annotatedTarget "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM637.SFSW.654" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000173 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-islets-langerhans/v1.2/assets/2d-ftu-pancreas-islets-langerhans.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002504 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002504 ; owl:annotatedTarget "A smooth muscle cell of the intestine." . [] oboInOwl:hasDbXref "DOI:10.1038/nrgastro.2012.168", "DOI:10.1111/j.1365-2982.2012.01986.x", "DOI:10.1371/journal.pcbi.1009644" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002504 ; owl:annotatedTarget """Enteric smooth muscle cells are a specialized type of cell found in the gastrointestinal tract. They are an integral part of the enteric nervous system, which regulates the functions of the gastrointestinal system. These cells have a unique structural organization that enables their primary function: the contraction and relaxation necessary for the propulsion of gastrointestinal contents. Smooth muscle cells in the enteric system possess unique attributes that distinguish them from other smooth muscle cells in the body. One crucial function is peristalsis, where these cells contract in a coordinated manner, generating a wave of contraction and relaxation. This peristaltic movement facilitates the movement of food particles through the digestive tract, playing a vital role in the digestion and absorption processes in animals. Additionally, these cells are responsible for maintaining the tone of gastrointestinal sphincters, controlling passage and preventing one-sided movement of the contents. Enteric smooth muscle cells are also involved in local immune responses of the gastrointestinal tract. They can communicate with local immune cells and secrete cytokines or other signaling molecules in response to infectious organisms, which makes them crucial mediocellular players in gastrointestinal homeostasis and response to disease. Their interactions with other cell types, such as neurons, myofibroblasts, and interstitial cells of Cajal, further contribute to these cells' role in maintaining the physiological functions of the gastrointestinal system. Overall, enteric smooth muscle cells provide an indispensable contribution to the complex operations of the digestive tract. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "enteric smooth muscle cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002504 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002504" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002505 ; owl:annotatedTarget obo:CL_0002454 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002505 ; owl:annotatedTarget "A CD11b-positive dendritic cell that is CD11b-high, CD45-positive, MHC-II-positive and CD103-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002506 ; owl:annotatedTarget obo:CL_0002454 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002506 ; owl:annotatedTarget "A CD11b-positive dendritic cell that is CD11b-low, CD45-positive, MHC-II-high and CD103-positive that is located in the liver." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002507 ; owl:annotatedTarget obo:CL_0000990 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002507 ; owl:annotatedTarget "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000174 ; owl:annotatedTarget "Any secretory cell that is capable of some steroid hormone secretion." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000174 ; owl:annotatedTarget "ZFA:0009106" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002508 ; owl:annotatedTarget obo:CL_0000990 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002508 ; owl:annotatedTarget "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-negative, MHC-II-positive, and CD4-negative and CD8a-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002509 ; owl:annotatedTarget obo:CL_0002507 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002509 ; owl:annotatedTarget "A langerin-positive lymph node dendritic cell that is CD103-positive and CD11b-low." . [] oboInOwl:hasDbXref "MESH:D008184", "PMID:31849844" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000175 ; owl:annotatedTarget "A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002510 ; owl:annotatedTarget obo:CL_0002507 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002510 ; owl:annotatedTarget "A langerin-positive lymph node dendritic cell that is CD103-negative and CD11b-high." . [] oboInOwl:hasDbXref "PMID:16790079" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000175 ; owl:annotatedTarget "corpus luteum cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002511 ; owl:annotatedTarget obo:CL_0002508 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002511 ; owl:annotatedTarget "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002512 ; owl:annotatedTarget obo:CL_0002508 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002512 ; owl:annotatedTarget "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-high." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002513 ; owl:annotatedTarget "A CD8-alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002514 ; owl:annotatedTarget "A CD8-alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment." . [] oboInOwl:hasDbXref "GOC:MH", "GOC:tfm", "PMID:12668625" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002515 ; owl:annotatedTarget "An interrenal chromaffin cell found in teleosts that contain heterogeneous vesicles with electron-dense granules located asymmetrically within the vesicular membrane." . [] oboInOwl:hasDbXref "GOC:MH", "GOC:tfm", "PMID:12668625" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002516 ; owl:annotatedTarget "A chromaffin cell interspersed among the interrenal epithelial layer of the anterior kidney of teloest fish." . [] oboInOwl:hasDbXref "GOC:MH", "GOC:tfm", "PMID:12668625" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002517 ; owl:annotatedTarget "An interrenal chromaffin cell found in teleosts that contain small, homogeneous electron-lucent granules that are separated from the vesicular membrane by a visible halo." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002518 ; owl:annotatedTarget obo:CL_1000497 . [] oboInOwl:hasDbXref "GOC:tfm", "KUPO:SJ" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002518 ; owl:annotatedTarget "An epithelial cell of the kidney." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0002518 ; owl:annotatedTarget "ZFA:0009374" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:mh", "GOC:tfm", "PMID:12668625" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002519 ; owl:annotatedTarget "An interrenal epithelial kidney cell is an epithelial cell found in the anterior kidney of teleosts fish. This cell type is arranged in layers around the posterior cardinal vein and contains many mitochondria with tubulovesicular cristae. Interrenal chromaffin cells are interspersed among the tissue layer created by this cell type." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19783135" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002520 ; owl:annotatedTarget "An insect excretory cell that regulates hemolymph composition by filtration and filtrate endocytosis." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002521 ; owl:annotatedTarget obo:CL_0000136 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002521 ; owl:annotatedTarget "An adipocyte that is part of subcutaneous adipose tissue." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002522 ; owl:annotatedTarget "A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002523 ; owl:annotatedTarget "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros." . [] oboInOwl:hasDbXref "ZFA:0001674" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002523 ; owl:annotatedTarget "mesonephric glomerular visceral epithelial cell" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19783135" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002524 ; owl:annotatedTarget "A disseminated nephrocyte is a nephrocyte that filters hemolymph and is found at scattered locations in the fat body or other tissues." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002525 ; owl:annotatedTarget "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." . [] oboInOwl:hasDbXref "doi:10.1007/s004180050142" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002525 ; owl:annotatedTarget "metanephric glomerular visceral epithelial cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002526 ; owl:annotatedTarget obo:CL_0001006 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000176 ; owl:annotatedTarget "Any secretory cell that is capable of some ecdysteroid secretion." . [] oboInOwl:hasDbXref "GOC:dsd", "PMID:19236899", "PMID:20309010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002526 ; owl:annotatedTarget "A dermal dendritic cell that is CD1a-negative and CD14-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002527 ; owl:annotatedTarget obo:CL_0002526 . [] oboInOwl:hasDbXref "GOC:dsd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002527 ; owl:annotatedTarget "An immature CD14-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002528 ; owl:annotatedTarget obo:CL_0002526 . [] oboInOwl:hasDbXref "GOC:dsd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002528 ; owl:annotatedTarget "A mature CD14-positive dermal dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002529 ; owl:annotatedTarget obo:CL_0001006 . [] oboInOwl:hasDbXref "GOC:dsd", "PMID:20309010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002529 ; owl:annotatedTarget "A dermal dendritic cell that is CD1a-positive and CD14-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002530 ; owl:annotatedTarget obo:CL_0002529 . [] oboInOwl:hasDbXref "GOC:dsd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002530 ; owl:annotatedTarget "An immature CD1a-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002531 ; owl:annotatedTarget obo:CL_0002529 . [] oboInOwl:hasDbXref "GOC:dsd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002531 ; owl:annotatedTarget "A mature CD1a-positive dermal dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000177 ; owl:annotatedTarget "Any secretory cell that is capable of some testosterone secretion." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002532 ; owl:annotatedTarget obo:CL_0000782 . [] oboInOwl:hasDbXref "GOC:dsd", "PMID:17332250" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002532 ; owl:annotatedTarget "A myeloid dendritic cell found in the blood that is CD16-positive." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000177 ; owl:annotatedTarget "ZFA:0009107" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002533 ; owl:annotatedTarget obo:CL_0002532 . [] oboInOwl:hasDbXref "GOC:dsd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002533 ; owl:annotatedTarget "An immature CD16-positive myeloid dendritic cell is CD80-low, CD86-low, and MHCII-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002534 ; owl:annotatedTarget obo:CL_0002532 . [] oboInOwl:hasDbXref "GOC:dsd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002534 ; owl:annotatedTarget "A mature CD16-positive myeloid dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "An epithelial cell of the cervix." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "cervical canal epithelial cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "cervical canal of uterus epithelial cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "cervix epithelial cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "cervix of uterus epithelial cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "epithelial cell of cervical canal" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "epithelial cell of cervical canal of uterus" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "epithelial cell of cervix of uterus" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12050120" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000178 ; owl:annotatedTarget "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "epithelial cell of neck of uterus" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "epithelial cell of uterine cervix" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "neck of uterus epithelial cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "uterine cervix epithelial cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002536 ; owl:annotatedTarget "An epithelial cell that is part of the amnion." . [] oboInOwl:hasDbXref "DOI:10.1016/j.coemr.2019.03.001", "DOI:10.1093/biolre/ioy059", "DOI:10.1210/clinem/dgaa603", "DOI:10.3389/fendo.2014.00006", "https://www.ncbi.nlm.nih.gov/books/NBK556007/#:~:text=Leydig%20cells%20are%20the%20primary,secondary%20sexual%20characteristics%20and%20behaviors." ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000178 ; owl:annotatedTarget """Leydig cells are a testosterone-secreting cell in the interstitial area in the testes of males. They are named after Franz Leydig, a German anatomist who discovered these cells in 1850. Uniquely situated within the soft connective tissue surrounding the seminiferous tubules, Leydig cells form an integral part of the male reproductive system. They are usually polygonal cells characterized by well developed smooth endoplasmic reticulum, high lipid content and a large round nucleus. They are found across mammalian species, including humans. The primary function of Leydig cells is the production of androgens, the male sex hormones, the most notable of which is testosterone. Leydig cells synthesize testosterone from cholesterol through a series of enzymatic reactions. The production and release of testosterone are mainly regulated by the luteinizing hormone (LH) released by the anterior pituitary gland. In response to LH, Leydig cells convert cholesterol into testosterone, which then plays a crucial role in the development and maintenance of primary and secondary male sexual characteristics. These include the formation and maturation of male reproductive organs, onset of spermatogenesis, and the presentation of male secondary sexual traits such as the deepening of the voice, growth of facial hair, development of muscles, and a broadening of shoulders. Apart from testosterone production, Leydig cells also secrete insulin-like factor 3 (INSL3) that is essential for testicular descent during embryonic development in males. Dysregulation or loss of Leydig cells can lead to numerous conditions like testosterone deficiency, infertility, and certain forms of testicular cancer. Although not typical, Leydig cells can regenerate if they are damaged, ensuring the continuous production of testosterone and maintaining male reproductive health. They provide an excellent model to study cell differentiation and hormone regulation, thereby enhancing our understanding of reproductive biology and associated disorders. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20446274", "PMID:21339039" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002537 ; owl:annotatedTarget "A mesenchymal stem cell of the amnion membrane." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000178 ; owl:annotatedTarget "ZFA:0009108" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002538 ; owl:annotatedTarget obo:CL_1000488 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:23720296" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002538 ; owl:annotatedTarget "An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes." . [] oboInOwl:hasDbXref "DOI:10.1002/hep.31252", "DOI:10.1016/j.ajpath.2023.02.012", "DOI:10.1016/j.biocel.2010.06.020", "DOI:10.1016/j.gastha.2022.07.015" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002538 ; owl:annotatedTarget """Intrahepatic cholangiocytes represent a subset of the biliary epithelial cells that form a network of tubes in the liver called the biliary tree The intrahepatic cholangiocytes reside specifically in the intrahepatic bile ducts and play a crucial role in liver physiology and bile production and secretion, thereby aiding in the digestion and absorption of fats in the small intestine. These specific cholangiocytes arise from bipotent hepatoblasts, whereas extrahepatic cholangiocytes share an embryologic origin with the ventral pancreas. Recent research suggests that there is also heterogeneity within populations of intrahepatic cholangiocytes with different transcriptional profiles, proliferative capacity, and biological function; for example, subpopulations differ in calcium-mobilizing receptors. The primary function of intrahepatic cholangiocytes is related to bile formation and maintenance of its flow. In addition to their secretory and absorptive activities, they are involved in the regulation of bile composition, volume, and alkalinization, contributing to the neutralization of the acidic chyme (partly digested food) that enters the intestine from the stomach. Intrahepatic cholangiocytes are also recognized for their role in liver regeneration and repair, often proliferating in response to injury. Intrahepatic cholangiocytes take part in certain pathological conditions, like primary biliary cirrhosis and cholangiocarcinoma. Changes in these cells often lead to abnormalities in bile formation and transport, causing cholestatic liver diseases. Overall, the primary and secondary functional activities of intrahepatic cholangiocytes are vital in maintaining liver function, digestive processes, and contributing to the body's response to liver injury. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0002538 ; owl:annotatedTarget "ZFA:0009379" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:23720296" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002538 ; owl:annotatedTarget "small bile duct cholangiocyte" . [] a owl:Axiom ; rdfs:label "intrahepatic cholangiocyte on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002538 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002538" . [] a owl:Axiom ; rdfs:label "Leydig cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000178 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000178" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002539 ; owl:annotatedTarget "A smooth muscle cell of the aorta." . [] oboInOwl:hasDbXref "DOI:10.1016/j.devcel.2005.05.017", "DOI:10.1111/febs.12414", "DOI:10.7150/ijbs.49871", "https://training.seer.cancer.gov/anatomy/cells_tissues_membranes/tissues/muscle.html", "https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-smooth-muscle-cell" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002539 ; owl:annotatedTarget """Aortic smooth muscle cells are specialized and highly differentiated muscle cells that are located in the tunica media layer of the aorta. They consist of spindle-shaped cells with a centrally located nucleus. These cells are rich in actin and myosin, muscle contractile proteins, that allow them to exert force and change shape. Aortic smooth muscle cells play a vital role in maintaining blood pressure and circulation, and are essential for vascular integrity and function. The primary function of these cells is contraction and relaxation, which enables the regulation of blood flow and pressure in the aorta, and helps in the distribution of oxygen and nutrients throughout the body. Additionally, a critical characteristic of smooth muscle cells is their plasticity. They can undergo phenotypic modulation in response to changes in their environment or vascular injury, switching from a contractile to a synthetic phenotype. The contractile phenotype is characterized by high contractility and low proliferation rate, while the synthetic phenotype is marked by increased cell proliferation and matrix synthesis but reduced contractile function. Aortic smooth muscle cells have a significant role in the physiological and pathological processes of the cardiovascular system. In the normal physiological state, they contribute to the elasticity and flexibility of the aorta. Conversely, in pathological states, changes in the function and structure of aortic smooth muscle cells are connected with various vascular diseases, including atherosclerosis, hypertension, and aneurysm. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "aortic smooth muscle cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002539 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002539" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002540 ; owl:annotatedTarget "A mesenchymal stem cell that is part of the bone marrow." . ( ) . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002541 ; owl:annotatedTarget "A mesenchymal stem cell of the chorionic membrane." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002543 ; owl:annotatedTarget obo:CL_0000071 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002543 ; owl:annotatedTarget "An endothelial cell that is part of the vein." . [] oboInOwl:hasDbXref "DOI:10.1007/s00441-008-0706-5", "DOI:10.1038/s41569-022-00770-1", "DOI:10.1038/s41598-021-01360-w", "DOI:10.3390/ijms20184411" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002543 ; owl:annotatedTarget """Vein endothelial cells form a thin layer of squamous cells, the endothelium, lining the interior surface of veins throughout the body. They shape the inner cellular lining of the entire vascular system, including the heart, playing a crucial role in blood circulation. The unique characteristic compact arrangement of these cells enables veins to act as a barrier between the blood (that can contain foreign substances) and the surrounding venous tissue and maintain the integrity of the vascular system. The primary function of vein endothelial cells is to control the exchange of substances between the bloodstream and the surrounding tissues. They facilitate selective transportation of molecules depending on their size and solubility, including gases, nutrients, hormones, and waste products. Vein endothelial cells also play a protective role by inhibiting the translocation of toxins or pathogens from blood to tissues. Additionally, these cells are involved in blood coagulation and inflammation response, primarily by producing substances that inhibit blood clot formation under normal conditions and initiating clotting when necessary. Another significant function of vein endothelial cells is the regulation of blood flow and blood pressure. They produce and release several substances, including nitric oxide and prostacyclin, which help in controlling vasodilation and vasoconstriction, thereby regulating blood pressure. These cells are also responsible for angiogenesis, the formation of new blood vessels, which is crucial during wound healing and in the formation of granulation tissue. Consequently, any dysfunction in vein endothelial cells can lead to severe health problems like atherosclerosis, hypertension, and thrombosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "vein endothelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002543 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002543" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002544 ; owl:annotatedTarget "An arterial endothelial cell that is part of the aorta endothelium." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002545 ; owl:annotatedTarget obo:CL_0002544 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002545 ; owl:annotatedTarget "An endothelial cell that is part of the thoracic endothelium." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002546 ; owl:annotatedTarget "An endothelial progenitor cell that participates in angiogenesis during development." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0002546 ; owl:annotatedTarget "ZFA:0005773" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002547 ; owl:annotatedTarget obo:CL_1000306 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002547 ; owl:annotatedTarget "A fibroblast of the aortic adventitia." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002548 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002548 ; owl:annotatedTarget obo:CL_0002494 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002548 ; owl:annotatedTarget "A fibroblast that is part of the heart." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002549 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002549 ; owl:annotatedTarget "A fibroblast that is part of the choroid plexus." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000179 ; owl:annotatedTarget "Any secretory cell that is capable of some progesterone secretion." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002550 ; owl:annotatedTarget "A fibroblast that is part of the conjuctiva of the eye." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002551 ; owl:annotatedTarget obo:CL_0002620 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002551 ; owl:annotatedTarget "Any skin fibroblast that is part of some dermis." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000179 ; owl:annotatedTarget "ZFA:0009109" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002552 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002552 ; owl:annotatedTarget "Any fibroblast that is part of some gingiva." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002553 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002553 ; owl:annotatedTarget "A fibroblast that is part of lung." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002554 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002554 ; owl:annotatedTarget "A fibroblast of the lymphatic system." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002555 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002555 ; owl:annotatedTarget "A fibroblast that is part of the mammary gland." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000024 ; owl:annotatedTarget obo:CL_0000021 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002556 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002556 ; owl:annotatedTarget "A fibroblast of the periodontium." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002557 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002557 ; owl:annotatedTarget "A fibroblast of pulmonary artery." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002558 ; owl:annotatedTarget "A fibroblast that is part of villous mesenchyme." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002559 ; owl:annotatedTarget "An animal cell that is part of a hair follicle." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002560 ; owl:annotatedTarget obo:CL_0002559 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002560 ; owl:annotatedTarget "An epithelial cell that resides in the inner root sheath of the hair follicle." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000180 ; owl:annotatedTarget "A steroid hormone secreting cell that secretes estradiol." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002561 ; owl:annotatedTarget obo:CL_0002559 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002561 ; owl:annotatedTarget "An epithelial cell that is part of the outer root sheath." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002562 ; owl:annotatedTarget obo:CL_0000362 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000180 ; owl:annotatedTarget "ZFA:0009110" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002562 ; owl:annotatedTarget "An epidermal cell that is part of the germinal matrix." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM853.HLFH.534" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002562 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-hair-follicle/v1.0/assets/2d-ftu-skin-hair-follicle.png" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002563 ; owl:annotatedTarget "An epithelial cell of the lining of the intestine." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0002563 ; owl:annotatedTarget "ZFA:0009399" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000181 ; owl:annotatedTarget "A cell whose primary function is intermediary metabolism." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002564 ; owl:annotatedTarget "A connective tissue cell of the nucleus pulposus cell of intervertebral disc." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002565 ; owl:annotatedTarget obo:CL_0000342 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002565 ; owl:annotatedTarget "A pigment cell located in the epithelium of the iris." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002566 ; owl:annotatedTarget "A melanocyte that appears darker due to content or amount of melanin granules." . [] oboInOwl:hasDbXref "PMID:10985850" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002566 ; owl:annotatedTarget "melanotic melanocyte" . [] oboInOwl:hasDbXref "PMID:10985850" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002566 ; owl:annotatedTarget "melanotic melanophore" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002567 ; owl:annotatedTarget "A melanocyte that appears lighter in color." . [] oboInOwl:hasDbXref "PMID:10985850" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002567 ; owl:annotatedTarget "amelanotic melanocyte" . [] oboInOwl:hasDbXref "PMID:10985850" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002567 ; owl:annotatedTarget "amelanotic melanophore" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002568 ; owl:annotatedTarget "A mesenchymal stem cell that is part of Wharton's jelly." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002569 ; owl:annotatedTarget "A mesenchymal stem cell of the umbilical cord." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002570 ; owl:annotatedTarget "A mesenchymal stem cell of adipose tissue." . [] oboInOwl:hasDbXref "DOI:10.1016/j.biopha.2019.108765", "DOI:10.1016/j.tibtech.2006.01.010", "DOI:10.1038/s41536-019-0083-6", "DOI:10.1096/fj.202100332R", "DOI:10.1111/dgd.12049" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002570 ; owl:annotatedTarget """Mesenchymal stem cells of adipose tissue, also known commonly as adipose-derived stem cells (ADSCs), are a population of adult stem cells that can be obtained easily from adipose tissues. They have many of the same regenerative properties as other mesenchymal stem cells, but are more easily accessible than bone marrow-derived stem cells. Adipose-derived stem cells show immense promise in the field of regenerative medicine due to their ability to differentiate into adipocytes, chondrocytes, myocytes, osteoblasts, and other cell types. ADSCs also possess immunomodulatory and homeostatic functions: they have the ability to suppress immune responses and provide a therapeutic environment for tissue repair and regeneration, as well as supporting the proliferation of adipocytes and the overall expansion of adipose tissue and contributing to the tissue's ability to react to demands of energy storage and mobilization. Dysfunction of these cells may contribute to metabolic complications observed in obesity and diabetes. ADSCs have been used for therapeutic applications such as pathological wound healing, severe refractory acute graft-versus-host disease, and idiopathic thrombocytopenic purpura. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "mesenchymal stem cell of adipose tissue on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002570 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002570" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002571 ; owl:annotatedTarget obo:CL_0000134 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002571 ; owl:annotatedTarget "A mesenchymal stem cell of liver." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002572 ; owl:annotatedTarget obo:CL_0000134 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002572 ; owl:annotatedTarget "A mesenchymal stem cell of the vertebrae." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:16807057" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002573 ; owl:annotatedTarget "A glial cell that myelinates or ensheathes axons in the peripheral nervous system." . [] oboInOwl:hasDbXref "DOI:10.1002/glia.23892", "DOI:10.1016/B978-0-444-52902-2.00005-9", "DOI:10.1016/j.biocel.2006.05.007", "DOI:10.1186/1742-2094-8-110", "DOI:10.1186/s13064-020-00140-y" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002573 ; owl:annotatedTarget """Schwann cells, also known as neurolemmocytes, are a type of glial cell located in the peripheral nervous system. These cells play a significant role in the healthy functioning of nerves by producing myelin, a fatty substance that forms a coating around nerve fibers. Myelin serves as an insulator and enhances the speed and efficiency of electrical nerve impulses; a single Schwann cell can myelinate a single axon. Myelination starts by the elongation and envelopment of the Schwann cell around the axon, followed by the synthesis and deposition of myelin layers. Some studies suggest that Schwann cells may regulate neuronal action potential, muscular contraction, and the sensitive response. While Schwann cells are most commonly known for the formation of the myelin sheath, some Schwann cells do not form myelin: Remak Schwann cells, a class of nonmyelinating Schwann cells, ensheath axons with smaller diameter, such as C fiber nociceptors in sciatic nerves and form Remak bundles. Schwann cells are found along both motor and sensory neurons and are crucial for the advancement and recovery of peripheral nerve injuries, due to their capacity to support nerve regeneration. In cases of nerve injury, Schwann cells play a vital role in recovery by initiating Wallerian degeneration, a process in which the part of the axon distal to the injury site degrades and is then cleared away. Following this, Schwann cells can guide the regrowth of the nerve, providing a conducive environment for axon regeneration. They remodel themselves into a regenerative phenotype, proliferate, and organize themselves into bands of Büngner that provide physical and chemical guidance for the regrowths of axons. This function of Schwann cells in the repair and regeneration of nervous system highlights their therapeutic potential in peripheral nerve injury treatments. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "PMID:32119275", "PMID:38638689" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002573 ; owl:annotatedTarget "neurolemmocyte" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000024 ; owl:annotatedTarget "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0412046911", "MESH:D022781", "PMID:19717280", "http://en.wikipedia.org/wiki/Hepatocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000182 ; owl:annotatedTarget "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." . [] oboInOwl:hasDbXref "PMID:16807057" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002573 ; owl:annotatedTarget "A myelinating Schwann cell wraps around a single axon. Myelination occurs in larger diameter axons, while a process called ensheathment occurs on smaller diameter axons in which a single cell wraps around multiple small, unmyelinated axons separating them with a thin layer of cytoplasm. The structure formed is called a Remak bundle." . [] a owl:Axiom ; rdfs:label "Schwann cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002573 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002573" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002574 ; owl:annotatedTarget obo:CL_0000499 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002574 ; owl:annotatedTarget "A stromal cell of the pancreas." . [] oboInOwl:hasDbXref "DOI:10.1016/j.biocel.2011.11.011", "DOI:10.1055/s-2007-1007096", "DOI:10.1083/jcb.201903090", "DOI:10.1111/j.1439-0396.2007.00752.x" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000182 ; owl:annotatedTarget """Hepatocytes are the major cell type constituting 70-80% of the liver's cytoplasmic mass, playing crucial roles in maintaining the body's metabolic homeostasis. Dimensions of mature hepatocytes typically range from 20 to 30 μm in humans, but size may vary depending on their location within the liver lobule. Hepatocytes are characterized by high biosynthetic, enzymatic, and endocytic activity. They contain abundant mitochondria, smooth and rough endoplasmic reticulum, peroxisomes, lysosomes, and a large nucleus that is often binucleate. The liver consists of three zones - the periportal Zone 1, midzone 2, and pericentral Zone 3 - which have differential nutrient and oxygen status, and damage susceptibility; hepatocytes in the different zones show signifcant functional heterogeneity ('hepatocyte functional zonation'). Hepatocytes are involved in a multitude of critical functions including the metabolism of lipids, carbohydrates, and proteins, the synthesis of serum proteins (e.g., albumin, transferrin, and lipoproteins), the detoxification and excretion of endogenous and exogenous substances, the storage of vitamins and minerals, and the production and secretion of bile. Heterocytes demonstrate a remarkable regenerative capacity, which enables the liver to recover from injury and loss of tissue mass. Notably, hepatocytes perform biotransformation with both phase I and phase II enzymes, which modify drugs, xenobiotics, and various substances for elimination from the body. Phase I enzymes, such as cytochrome P450, catalyze both oxidative and reductive reactions of many xenobiotics; many of the products of phase I enzymes are substrates for the phase II enzymes, which catalyze conjugation reactions. Alterations in hepatocyte function have significant implications for overall human health and disease. Certain conditions, such as hepatitis, cirrhosis, and liver cancer, can profoundly affect hepatocyte structure and function, thereby disrupting the liver's ability to perform its vital roles within the body. As the primary site for drug metabolism, changes in hepatocyte function can also impact the effectiveness and toxicity of pharmaceuticals. The regenerative ability of hepatocytes makes them valuable cells for liver regenerative medicine and bioartificial liver support systems, and their study has provided significant insights into liver biology and disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002575 ; owl:annotatedTarget obo:CL_0000669 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002575 ; owl:annotatedTarget "A pericyte of the central nervous system." . [] oboInOwl:hasDbXref "GO:tfm", "NCIT:C41442", "PMID:25818566", "http://en.wikipedia.org/wiki/Perineurium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002576 ; owl:annotatedTarget "A glial cell that is part of the perineurium. This cell type has thin long bipolar cytoplasmic processes, pinocytotic vesicles, fragments of external lamina and/or external lamina-like material, attachment plaques, and desmosome-like junctions. Perineurial cells historically have been referred to as fibroblasts because of shape; however, unlike fibroblasts, a perineurial cell: does not have a compact nucleus and large endoplasmic reticulum; does have a double basement membrane opposed to a single basal lamina; is carefully joined to other perineurial cells by tight junctions into a single sheet as opposed to arranged in a large mass; and finally, can surround a small axon bundle at a nerve terminal whereas a fibroblast cannot." . [] oboInOwl:hasDbXref "PMID:25818566" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002576 ; owl:annotatedTarget "perineurial glial cell" . [] oboInOwl:hasDbXref "PMID:36244793" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002576 ; owl:annotatedTarget "There are studies that largely accept the idea that the perineurial cell is a modified fibroblast with myofibroblastic features." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000182 ; owl:annotatedTarget "ZFA:0009111" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002577 ; owl:annotatedTarget obo:CL_0000349 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002577 ; owl:annotatedTarget "An epithelial cell of the placenta." . [] a owl:Axiom ; rdfs:label "hepatocyte on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000182 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000182" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002578 ; owl:annotatedTarget obo:CL_0002334 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002578 ; owl:annotatedTarget "A preadipocyte found in mesenteric tissue." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002579 ; owl:annotatedTarget obo:CL_0002334 . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM889.CJPK.447" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000182 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" . [] oboInOwl:hasDbXref "PMID:21484051" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002579 ; owl:annotatedTarget "A preadipocyte that is part of an omentum." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002580 ; owl:annotatedTarget obo:CL_0002334 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002580 ; owl:annotatedTarget "A preadipocyte that is part of the breast." . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000183 ; owl:annotatedTarget "A cell whose primary function is to shorten." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002581 ; owl:annotatedTarget obo:CL_0002334 . [] oboInOwl:hasDbXref "PMID:20106964", "PMID:31079959" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002581 ; owl:annotatedTarget "A preadipocyte that is part of a perirenal fat tissue." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002582 ; owl:annotatedTarget "A preadipocyte that is part of visceral tissue." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000185 ; owl:annotatedTarget "Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002583 ; owl:annotatedTarget obo:CL_0002334 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002583 ; owl:annotatedTarget "A preadipocyte that is part of subcutaneous tissue." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002584 ; owl:annotatedTarget obo:CL_0002518 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002584 ; owl:annotatedTarget obo:CL_0002681 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002584 ; owl:annotatedTarget "An epithelial cell of the kidney cortex." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000185 ; owl:annotatedTarget "ZFA:0009113" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002585 ; owl:annotatedTarget obo:CL_0000071 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002585 ; owl:annotatedTarget "A blood vessel endothelial cell that is part of the retina." . [] oboInOwl:hasDbXref "DOI:0.1016/j.preteyeres.2015.08.001", "DOI:10.1016/j.preteyeres.2012.08.004", "DOI:10.1038/nature04482", "DOI:10.5301/EJO.2010.6049" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002585 ; owl:annotatedTarget """Retinal blood vessel endothelial cells constitute the innermost lining of the blood vessels found in the retina, the light-sensitive layer of tissue at the back of the eye. The primary role of these cells revolves around their location within the retinal vascular system, forming the structure of the blood-retinal barrier, a subset of the larger blood-ocular barrier system. The endothelial cells are particularly involved in the growth of new retinal blood vessels from pre-existing ones (angiogenesis); this is critical in managing the amount of oxygen and essential nutrients delivered to the ocular tissues. They are crucial for maintaining homeostasis in the retinal environment by controlling the exchange of molecules between the blood and the retina. Furthermore, they mediate immune cell trafficking, supporting the immune privilege of the eye by preventing the unrestricted infiltration of inflammatory cells into the retina, thus maintaining ocular health and normal vision. The malfunction or dysfunction of retinal blood vessel endothelial cells is implicated in numerous ocular pathologies, particularly diabetic retinopathy, which is one of the leading causes of blindness worldwide. In such conditions, the compromise in the integrity of the blood-retinal barrier and excess angiogenesis can lead to retinal edema and pathological neovascularization, resulting in vision loss. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "retinal blood vessel endothelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002585 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002585" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "MESH:D058628", "PMID:19800625", "PMID:20630469", "PMID:22387320" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000186 ; owl:annotatedTarget "An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002586 ; owl:annotatedTarget "An epithelial cell of the retinal pigmented epithelium." . [] oboInOwl:hasDbXref "DOI:10.1111/febs.16018", "DOI:10.1152/physrev.00021.2004", "DOI:10.3389/fphar.2021.727870/full", "https://www.sciencedirect.com/topics/chemistry/retinal-pigment" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002586 ; owl:annotatedTarget """Retinal pigment epithelial (RPE) cells form a single layer of cells at the back of the eye sandwiched between the neurosensory retina and the choroid, playing a significant role in maintaining vision health. These pigment-laden cells are highly specialized and perform an array of metabolic and transport functions essential for the maintenance of the photoreceptor cells (rods and cones) in the retina. The pigmentation of RPE cells actively aids in the absorption of excess light and the prevention of light scattering, thus enhancing the eye's optical properties. The retinal pigment epithelium forms a key part of the blood/retina barrier. The cells have long sheet-like microvilli on their apical membrane that project into the light-sensitive outer segments of the photoreceptors, forming a close structural interaction. The basolateral membrane of the RPE interacts with the underlying Bruch’s membrane, which separates the RPE cells from fenestrated endothelium of the choriocapillaris. RPE cells support the photoreceptor by providing them with oxygen and nutrients (such as glucose, retinol and fatty acids) and removing waste products. They also recycle the visual pigment, in a process called the \"visual cycle\", where the RPE cells play a vital role in the regeneration of visual pigment (11-cis retinol) following the absorption of light. This is essential for the maintenance of photoreceptor excitability. Beyond this, RPE cells take part in the phagocytosis process, where they digest the shed ends of photoreceptor outer segments, thus, preventing the build-up of waste residue that could otherwise harm retinal health. They also secrete various factors, including growth factors required to maintain the structural integrity of choriocapillaris endothelium and photoreceptors, as well as immunosuppressive factors that play an important role in establishing the immune privilege of the eye. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "retinal pigment epithelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002586 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002586" . [] oboInOwl:hasDbXref "PMID:8731193" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000186 ; owl:annotatedTarget "MFB" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002588 ; owl:annotatedTarget "A smooth muscle cell of the umbilical vein." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002589 ; owl:annotatedTarget "A smooth muscle cell of the bachiocephalic vasculature." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000024 ; owl:annotatedTarget "ZFA:0005878" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002590 ; owl:annotatedTarget obo:CL_0000359 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002590 ; owl:annotatedTarget "A vascular associated smooth muscle cell of the brain vasculature." . [] oboInOwl:hasDbXref "MESH:D032342" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000187 ; owl:annotatedTarget "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002591 ; owl:annotatedTarget "A smooth muscle of the pulmonary artery." . [] oboInOwl:hasDbXref "DOI:10.1016/j.apsb.2012.12.007", "DOI:10.1124/pr.115.010652", "https://www.sciencedirect.com/topics/medicine-and-dentistry/pulmonary-artery-smooth-muscle-cell" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002591 ; owl:annotatedTarget """Smooth muscle cells of the pulmonary artery form a principal component of the pulmonary artery's media layer, the middle section of the artery wall typically found between endothelial inner layer (intima) and the outermost connective tissue layer (adventitia). The unique structure of these cells, defined by fusiform shape and the absence of striations, sets them apart from other muscle cell types, including cardiac and skeletal. The primary function of smooth muscle cells of the pulmonary artery is to regulate the diameter of the pulmonary artery, which in turn controls the flow of blood into the lungs. They accomplish this task through the contraction and relaxation, indicative of vasoconstriction and vasodilation respectively. When these cells contract, the diameter of the artery narrows, leading to reduced blood flow. Conversely, relaxation of these cells widens the artery, facilitating increased blood flow. Such blood flow modulation is crucial for the maintenance of blood pressure and ensuring that the lungs receive an adequate blood supply for efficient oxygen exchange. As a result, abnormal function or proliferation of these cells can contribute to conditions such as pulmonary hypertension, a condition characterized by high blood pressure in the arteries leading to the lungs. This can occur due to hypoxia (lack of enough oxygen), leading to excessive constriction or proliferation of the smooth muscle cells. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "smooth muscle cell of the pulmonary artery on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002591 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002591" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002592 ; owl:annotatedTarget "A smooth muscle cell of the coronary artery." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000187 ; owl:annotatedTarget "FBbt:00005074" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002593 ; owl:annotatedTarget "A smooth muscle of the internal thoracic artery." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000187 ; owl:annotatedTarget "ZFA:0009114" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002594 ; owl:annotatedTarget "A smooth muscle cell of the umbilical artery." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002595 ; owl:annotatedTarget "A smooth muscle cell of the subclavian artery." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002596 ; owl:annotatedTarget "Smooth muscle cell of the carotid artery." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002597 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "GC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002597 ; owl:annotatedTarget "A smooth muscle cell of the bladder." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002598 ; owl:annotatedTarget "Any smooth muscle cell that is part of some bronchus." . [] oboInOwl:hasDbXref "DOI:10.1152/japplphysiol.00313.2006", "DOI:10.1183/09031936.00019810", "https://www.ncbi.nlm.nih.gov/books/NBK537353/", "https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/bronchial-muscle" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002598 ; owl:annotatedTarget """Bronchial smooth muscle cells are specialized types of cells found in the bronchi of the respiratory system in mammals. These bronchi are tubular structures that function to carry air from the trachea into the lungs. As part of the smooth muscle tissue, bronchial smooth muscle cells are involuntary cells, meaning they function with minimal direct voluntary control. They are characterized by their elongated spindle-shaped structure, with each cell containing a single central nucleus. The primary function of bronchial smooth muscle cells is to control airway diameter, which directly influences the flow of air into and out of the lungs. Muscular contractions and relaxations mediated by these cells enable the bronchi to constrict or expand, facilitating the regulation of respiratory airflow. Additionally, these cells play a pivotal role in immune responses as they produce and release various substances that can instigate or lessen inflammation of airway tissue. Furthermore, bronchial smooth muscle cells can proliferate and lay down collagen and other extracellular matrix proteins, contributing to the structural integrity of the bronchial tubes. In pathological conditions, such as asthma and chronic obstructive pulmonary disease, the function and biology of bronchial smooth muscle cells change. Asthma, for example, is associated with an abnormal increase in the mass of the bronchial smooth muscles, leading to narrowing of the airways and resultant breathing difficulties. These cells also exhibit altered contractile behavior and an augmented immune response during inflammatory lung diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "bronchial smooth muscle cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002598 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002598" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002599 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002599 ; owl:annotatedTarget "A smooth muscle cell of the esophagus." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002600 ; owl:annotatedTarget "A smooth muscle cell of the trachea." . [] oboInOwl:hasDbXref "DOI:10.1016/s1357-2725(02)00259-5", "https://www.ncbi.nlm.nih.gov/books/NBK9961", "https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/airway-smooth-muscle" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002600 ; owl:annotatedTarget """Smooth muscle cells of the trachea have a characteristic 'smooth' (non-striated) appearance under the microscope, a distinguishing feature that differentiates them from skeletal and cardiac muscle cells. The smooth appearance is due to the organization of actin and myosin filaments in the cell, which allows for a controlled, contractile function. These cells play a key role in controlling the diameter of the trachea, thus regulating the airflow. They are responsible for the involuntary constriction and relaxation of the trachea influencing the air passage during various physiological behaviors like breathing, coughing, and sneezing. This autonomic control allows for adaptations to specific body requirements without conscious control, such as increasing air flow during exercise or restricting it during rest. In conditions such as asthma, chronic bronchitis, and emphysema, there are changes in smooth muscle cells. For example, the mass of smooth muscle cells increases in chronic airway diseases, possibly in response to chronic inflammation. This increase may indicate a pathological condition or be a part of the body's response to injury and repair. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "smooth muscle cell of trachea on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002600 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002600" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002601 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002601 ; owl:annotatedTarget "A smooth muscle cell of the uterus." . [] oboInOwl:hasDbXref "DOI:10.1177/0036850419850431", "DOI:10.1203/00006450-199811000-00001", "DOI:10.3791/56639", "https://www.ncbi.nlm.nih.gov/books/NBK532927/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002601 ; owl:annotatedTarget """Uterine smooth muscle cells are specialized cells that make up the majority of the uterus and in particular, the myometrium. The myometrium is a thick, involuntary muscle layer, principally consisting of verticillate cell bundles that sculpt the helical architecture of the uterus. This dense muscular tissue, packed with uterine smooth muscle cells, is responsible for the significant contractile force witnessed during the physical processes of labor and childbirth. In the non-pregnant uterus, they exist in a quiescent phase. Upon implantation, these cells are primarily responsible for the expansion consequently allowing the uterus to accommodate the growing fetus. Towards the end of pregnancy, under the influence of hormonal and mechanical signals, uterine smooth muscle cells transition from a relaxed phase to an active contractile phase, culminating in the delivery of the fetus. At the cellular level, these transitions involve significant changes in the electrophysiological properties of uterine smooth muscle cells. Governed by a complex interplay of ion channels, transporters, and signaling proteins, these cells adjust their electrical activity, conduction properties, and contracting mechanisms. Any issues with these processes can result in problems such as preterm birth or labor dysfunction. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "uterine smooth muscle cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002601 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002601" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002602 ; owl:annotatedTarget obo:CL_0002320 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002602 ; owl:annotatedTarget "Any connective tissue cell that is part of some annulus fibrosus disci intervertebralis." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000188 ; owl:annotatedTarget "A somatic cell located in skeletal muscle." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002603 ; owl:annotatedTarget obo:CL_0000127 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002603 ; owl:annotatedTarget "An astrocyte of the cerebellum." . [] oboInOwl:hasDbXref "DOI:10.1002/cphy.c160033", "DOI:10.3390/biology10101056", "https://www.nature.com/scitable/topicpage/the-sliding-filament-theory-of-muscle-contraction-14567666/", "https://www.ncbi.nlm.nih.gov/books/NBK537139", "https://www.ncbi.nlm.nih.gov/books/NBK9961/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000188 ; owl:annotatedTarget """Skeletal muscle cells, or myocytes, are essential for the musculoskeletal system, featuring a striated appearance from tightly packed sarcomeres. These elongated, multi-nucleated cells convert ATP into mechanical energ and are key for voluntary movement and posture. They also are responsible for maintaining body temperature, storing nutrients, and stabilizing joints. Skeletal muscle cells organize themselves tightly into bundles to form muscle fibers. Embedded within each of these cells are thousands of myofibrils, which are made up of the contractile proteins, actin (the thin filament), and myosin (the thick filament). Contraction of a skeletal muscle cell occurs when these myofibrils shorten, a process driven by the sliding of actin and myosin filaments over each other in a mechanism famously known as the sliding filament theory. Additionally, skeletal muscle cells exhibit a high degree of plasticity, which allows for their adaptation in response to alterations in functional demands or damages. They have an innate regenerative capacity due to the presence of satellite cells—quiescent muscle stem cells that reside within the muscle fibers. Upon muscle injury, these satellite cells become activated, proliferate, and differentiate into new muscle cells, thereby contributing to the repair and growth of injured skeletal muscle. With this, skeletal muscle cells serve not only a pivotal biomechanical function but also possess a great capacity for self-healing and regeneration. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-7258-9596" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002604 ; owl:annotatedTarget "An astrocyte that is part of the hippocampus." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002605 ; owl:annotatedTarget "A transcriptomically distinct astrocyte that is found in the cerebral cortex." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000188 ; owl:annotatedTarget "ZFA:0009115" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002606 ; owl:annotatedTarget obo:CL_0000127 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002606 ; owl:annotatedTarget "An astrocyte of the spinal cord." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002607 ; owl:annotatedTarget "A neural crest cell that gives rise to cells of the enteric nervous system." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002608 ; owl:annotatedTarget "A neuron with a soma found in the hippocampus." . [] a owl:Axiom ; rdfs:label "cell of skeletal muscle on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000188 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000188" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002609 ; owl:annotatedTarget "OBSOLETE. A CNS neuron of the cerebral cortex." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002610 ; owl:annotatedTarget "A neuron of the raphe nuclei." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002611 ; owl:annotatedTarget "A CNS neuron of the dorsal spinal cord." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002612 ; owl:annotatedTarget "A neuron of the ventral spinal cord." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0323052908" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000189 ; owl:annotatedTarget "A muscle cell that develops tension more slowly than a fast-twitch fiber." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002613 ; owl:annotatedTarget "A neuron of the striatum." . [] oboInOwl:hasDbXref "DOI:10.1093/ptj/81.11.1810", "DOI:10.1186/s13578-015-0054-6", "DOI:10.3389/fphys.2021.747214", "https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/slow-muscle-fiber" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000189 ; owl:annotatedTarget """Slow muscle cells, as the name implies, are a type of muscle cell well known for their slow contractile speed. They are also referred to as type I, slow-twitch, or red muscles because of their high myoglobin content which gives them a dark, reddish appearance. These cells are predominantly found in the postural muscles of the body, such as those in the back and lower limbs. A defining characteristic of slow muscle cells is their significant resistance to fatigue. This is largely due to their efficient oxidative metabolism, which allows them to continuously contract over extended periods without succumbing to fatigue. This extraordinary endurance is facilitated by a high concentration of mitochondria, which enables the efficient use of oxygen for energy production, and capillaries, which supplies the necessary oxygen and nutrients. Additionally, these cells have an abundant supply of myoglobin, a protein that stores and transports oxygen within the muscle cell, further supporting their aerobic metabolism. The primary role of slow muscle cells in the human body is to provide sustained, low-intensity contractions over a prolonged period. They are responsible for maintaining posture and providing stability, rather than delivering short, powerful bursts of activity. They play a pivotal role in supporting various physical activities such as standing, walking, or any form of exercise that requires endurance over speed. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002614 ; owl:annotatedTarget "A neuron of the substantia nigra." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002615 ; owl:annotatedTarget obo:CL_0000136 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002615 ; owl:annotatedTarget "An adipocyte that is part of omentum tissue." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000189 ; owl:annotatedTarget "ZFA:0009116" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002616 ; owl:annotatedTarget obo:CL_0000136 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002616 ; owl:annotatedTarget "An adipocyte of perirenal fat tissue." . [] oboInOwl:hasDbXref "ISBN:0815316208" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000189 ; owl:annotatedTarget "slow muscle fiber" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002617 ; owl:annotatedTarget obo:CL_0000136 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002617 ; owl:annotatedTarget "An adipocyte that is part of the breast." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002618 ; owl:annotatedTarget "An endothelial cell of the umbilical vein." . [] oboInOwl:hasDbXref "DOI:10.1002/cyto.a.20952", "DOI:10.1007/s12015-006-0015-x", "DOI:10.1172/JCI107470", "DOI:10.3390/app10030938", "https://www.ncbi.nlm.nih.gov/books/NBK53254/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002618 ; owl:annotatedTarget """Endothelial cells of the umbilical vein form the inner lining of the veins found in the umbilical cord. They are involved in tube formation and migration which are essential for angiogenesis, the process of generating new blood vessels; this is critical during the fetal stage for the development of the circulatory system. Endothelial cells of the umbilical vein also play a role in controlling the passage of white blood cells into tissues during inflammatory responses. Because human umbilical vein endothelial cells (HUVECs) can easily be derived from the umbilical cord, and because they express common endothelial cell markers, they have been used as an epithelial cell model for studies on cell proliferation, migration, angiogenesis, and inflammation. They have been used as models for vascular diseases like atherosclerosis, for investigating how tumor cells infiltrate blood vessels and form metastases. Thus, while endothelial cells of the umbilical vein play a critical role in vascular biology, they also represent a powerful tool in disease studies and potential treatment strategies. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "endothelial cell of umbilical vein on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002618 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002618" . [] a owl:Axiom ; rdfs:label "slow muscle cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000189 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000189" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20807818", "PMID:9020076", "WikipediaVersioned:Endothelial_progenitor_cell&oldid=1069930016" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002619 ; owl:annotatedTarget "An adult angioblastic cell released from the bone marrow, or from the kidney in some teleost species, capable of blood circulation and participation in angiogenesis by differentiating into blood vessel endothelial cells." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002620 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002620 ; owl:annotatedTarget "A fibroblast of skin." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM476.JQZD.394" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002620 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-dermal-papilla/v1.1/assets/2d-ftu-skin-dermal-papilla.png" . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002621 ; owl:annotatedTarget "Any stratified squamous epithelial cell that is part of some gingival epithelium." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0323052908" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000190 ; owl:annotatedTarget "A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002622 ; owl:annotatedTarget obo:CL_0000499 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002622 ; owl:annotatedTarget "A stromal cell of the prostate." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002623 ; owl:annotatedTarget obo:CL_0000622 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002623 ; owl:annotatedTarget "An acinar cell of salivary gland." . [] oboInOwl:hasDbXref "DOI:10.1152/japplphysiol.00636.2019", "DOI:10.3389/fcell.2018.00125", "DOI:10.4161/org.4.3.6312", "https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/fast-muscle-fiber" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000190 ; owl:annotatedTarget """Fast muscle cells, also known as type II muscle fibers, are a particular type of muscle cell that specializes in conducting rapid, high-intensity contractions. These cells are primarily found within skeletal muscle groups that are directly involved in gross motor activities, such as running, jumping, or lifting heavy weights. The designation \"fast\" refers to their speed of contraction in response to neural stimuli, which is significantly quicker when compared to other muscle cell types such as slow-twitch or type I muscle fibers. The primary function of fast muscle cells revolves around their role in anaerobic metabolism, which provides the energy needed for short, forceful bursts of power. They contain a high concentration of glycolytic enzymes that facilitate this process, leading to a swift break down of glucose to generate ATP (adenosine triphosphate), the primary energy currency in biological systems. On the downside, the byproduct of this very rapid, anaerobic metabolic process is lactic acid, which can build up and cause muscle fatigue. Fast muscle cells can be further classified into two subtypes based on their metabolic characteristics: type IIa and type IIb/x. Type IIa cells, also known as fast oxidative-glycolytic fibers, possess a good oxygen supply and can function in both anaerobic and aerobic conditions, exhibiting moderate resistance to fatigue. On the other hand, type IIb/x cells, also known as fast glycolytic fibers, primarily rely on anaerobic metabolism and tire out a lot quicker. Both these subtypes can adapt to changing demands due to exercise and conditioning, highlighting the plasticity that is a key characteristic of these versatile muscle cells. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002624 ; owl:annotatedTarget obo:CL_0000510 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002624 ; owl:annotatedTarget "A paneth cell of the appendix." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002625 ; owl:annotatedTarget obo:CL_0000077 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000190 ; owl:annotatedTarget "ZFA:0009117" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002625 ; owl:annotatedTarget "A cell of the seminiferous tubule epithelium." . [] oboInOwl:hasDbXref "GOC:dsd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002626 ; owl:annotatedTarget "An immature astrocyte." . [] oboInOwl:hasDbXref "GOC:dsd", "PMID:12898703", "PMID:8734446" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002627 ; owl:annotatedTarget "A mature astrocyte that is capable of producing cytokines." . [] oboInOwl:hasDbXref "GOC:dsd", "PMID:18396103", "PMID:19461673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002628 ; owl:annotatedTarget "An immature microglial cell with a ramified morphology." . [] oboInOwl:hasDbXref "PMID:18396103" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002628 ; owl:annotatedTarget "quiescent microglia" . [] oboInOwl:hasDbXref "PMID:18396103" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002628 ; owl:annotatedTarget "resting microglia" . [] a owl:Axiom ; rdfs:label "fast muscle cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000190 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000190" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002629 ; owl:annotatedTarget obo:CL_0000129 . [] oboInOwl:hasDbXref "GOC:dsd", "PMID:11517395", "PMID:14612429", "PMID:15246020", "PMID:16177057", "PMID:18396103", "PMID:20021364" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002629 ; owl:annotatedTarget "A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation." . [] oboInOwl:hasDbXref "DOI:10.1111/j.1745-7254.2007.00625.x", "DOI:10.1111/jnc.15689", "DOI:10.3389/fimmu.2022.997786", "DOI:10.4103/1673-5374.226386", "DOI:10.4103/1673-5374.322423" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002629 ; owl:annotatedTarget """Mature microglial cells represented one of the macrophage populations within the central nervous system (CNS). Microglial cells serve as the primary immune defense mechanism within the CNS, playing active roles in maintaining brain homeostasis and responding to pathological processes. In response to pathogens and injuries, microglial cells mature and change their morphology from a ramified shape with small processes (normal state) to an amoeboid shape (mature state). Mature microglial cells possess multiple functional abilities, thereby enabling them to execute diverse roles in order to maintain the health of surrounding neural cells. They act to clear away cellular debris, dead neurons, or plaque formations through the process of phagocytosis. They are also continuously scanning their environment and are able to detect subtle changes in the neural landscape caused by injury, disease, or infection. Upon detection of such changes, these cells become activated and present antigens and secrete cytokines and chemokines to initiate an inflammation response, which sustains the brain’s defense against injurious agents. Their role is not solely destructive or defensive: mature microglial cells also contribute to neurodevelopment by guiding the formation of neural circuits, synaptogenesis, and remodeling. Furthermore, they assist in managing synaptic plasticity, a key process in learning and memory functions. While the dysregulation of microglial cells has been implicated in various neurodegenerative diseases, they are also regarded as potential therapeutic targets for such conditions, given their crucial roles in maintaining CNS health. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "PMID:18396103" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002629 ; owl:annotatedTarget "activated microglia" . [] oboInOwl:hasDbXref "PMID:18396103" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002629 ; owl:annotatedTarget "reactive microglia" . [] a owl:Axiom ; rdfs:label "mature microglial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002629 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002629" . [] oboInOwl:hasDbXref "GO:0034304", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002630 ; owl:annotatedTarget "A spore formed from bacteria in the order Actinomycetales." . [] oboInOwl:hasDbXref "MESH:D032389", "PMID:9315361", "http://en.wikipedia.org/wiki/Smooth_muscle_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000192 ; owl:annotatedTarget "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002631 ; owl:annotatedTarget "Any epithelial cell that is part of some upper respiratory tract epithelium." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002632 ; owl:annotatedTarget "Any epithelial cell that is part of some lower respiratory tract epithelium." . [] oboInOwl:hasDbXref "DOI:10.1093/ptj/81.11.1810", "https://training.seer.cancer.gov/anatomy/muscular/types.html", "https://www.ncbi.nlm.nih.gov/books/NBK10854/", "https://www.ncbi.nlm.nih.gov/books/NBK526125", "https://www.ncbi.nlm.nih.gov/books/NBK556137/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000192 ; owl:annotatedTarget """Smooth muscle cells are a specialized type of muscle cells that are primarily found within the walls of hollow organs such as the intestine, stomach, bladder, uterus, and blood vessels. These cells are an essential component of the autonomic nervous system controling involuntary movements within the body. Smooth muscle cells play a vital role in many physiological processes due to their unique functionality. They can contract and relax in a slow, sustained, and controlled manner to help modulate the size and shape of the lumens of the organs they surround. For example, in the digestive system, coordinated contraction and relaxation of smooth muscle cells propels food along the gastrointestinal tract - a process known as peristalsis. In the blood vessels, the smooth muscle cells, by contracting or relaxing, either constrict or dilate the vessels, which in turn, help regulate blood flow and pressure. On a cellular level, smooth muscle cells possess a single, centrally located nucleus and contain an arranged network of actin and myosin filaments, which are the proteins responsible for muscle contraction. Unlike their counterparts in skeletal or cardiac muscles, these cells lack specific contact points for these filaments, hence the lack of visible striations. Furthermore, the contraction of smooth muscle cells is regulated by hormones and neurotransmitters, such as acetylcholine and norepinephrine, adding an additional layer of complex regulation to these highly specialized cells. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20699479" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002633 ; owl:annotatedTarget "A basal cell in the respiratory tract." . [] oboInOwl:hasDbXref "DOI:10.1186/s12931-022-02042-5", "DOI:10.3389/falgy.2021.787128", "DOI:110.1038/s41385-020-00370-7" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002633 ; owl:annotatedTarget """Respiratory basal cells are highly specialized cells that serve a crucial role in the human airway epithelium, predominantly found lining the surfaces of the trachea and bronchi. These cells exhibit a distinctive columnar shape and are attached directly to the basal lamina. They are characterized by the presence of high amounts of cytoplasmic keratins, predominantly keratin 5 and 14, and transcription factor tumor protein (tp63), which set them apart from other types of lung epithelial cells such as ciliated cells and secretory cells. Basal cells are essential for maintaining airway integrity. They make up one third of all respiratory epithelial cells and serve as stem cells as they can transform into different cell types, like goblet cells, ciliated cells, and club cells, when needed for homeostatic maintenance of the epithelial barrier or to repair and restore a healthy cellular environment after injury. Their position at the interface between the internal environment and the external atmosphere makes these cells a first line of defense against air-borne irritants, allergens, and pathogens. Their robust, intrinsic reparative properties facilitate effective recovery from such adversities. However, damage to respiratory basal cells or abnormalities in their function are associated with several respiratory pathologies such as asthma, chronic obstructive pulmonary disease, and lung cancer. Therefore, understanding these cells' function, and their role in disease, is crucial for the development of new therapeutic strategies for respiratory disorders. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "respiratory basal cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002633 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002633" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000192 ; owl:annotatedTarget "ZFA:0009118" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002634 ; owl:annotatedTarget "An epithelial cell of the anal column." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002635 ; owl:annotatedTarget "A nonkeratinized epithelial cell of the anal canal." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002636 ; owl:annotatedTarget "A nonkeratinized cell epithleial cell of the inferior part of the anal canal." . [] oboInOwl:hasDbXref "PMID:9315361" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000192 ; owl:annotatedTarget "SMCs" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002637 ; owl:annotatedTarget "An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002638 ; owl:annotatedTarget obo:CL_0002633 . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0011691", "PMID:15960971" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002638 ; owl:annotatedTarget "A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole. This cell types gives rise to alveolar cell types and club cells in response to lung injury. This cell type expresses markers Scgb1a1 and Sftpc." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20942606" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002639 ; owl:annotatedTarget "An amniotic stem cell is a mesenchymalstem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue type such as skin, cartilage, cardiac tissue, nerves, muscle, and bone" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20446274" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002640 ; owl:annotatedTarget "An epithelial fate stem cell derived form the amnion membrane." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002641 ; owl:annotatedTarget "An epithelial cell of the esophageal gland proper." . [] oboInOwl:hasDbXref "GOC:tfm", "http://web.mac.com/wjkrause/iWeb/Histology/Blog/E3FA5916-1AA9-4885-B579-5051838D98CB.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002642 ; owl:annotatedTarget "An epithelial cell of the esophageal cardiac gland that occurs both in the proximal and distal esophagus, within the lamina propia." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002643 ; owl:annotatedTarget "An epithelial cell of stratum corneum of esophageal epithelium that lacks keratin." . [] oboInOwl:hasDbXref "MESH:D032389" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000192 ; owl:annotatedTarget "myocytes, smooth muscle" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002644 ; owl:annotatedTarget "An endothelial cell of viscerocranial mucosa that is part of the tympanic region of the viscerocranial mucosa." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002645 ; owl:annotatedTarget "An endocranial viscerocranial mucosa cell that is part of viscerocranial mucosa." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002646 ; owl:annotatedTarget "An ecto-epithelial cell of the buccal region of the viscerocranial mucosa." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002647 ; owl:annotatedTarget "An ecto-epithelial cell of the palatal region of the viscerocranial mucosa." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002648 ; owl:annotatedTarget "An ecto-epithelial cell of the nasal region of the viscerocranial mucosa." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002649 ; owl:annotatedTarget "An ecto-epithelial cell of the gingival region of the viscerocranial mucosa." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002650 ; owl:annotatedTarget "An ecto-epithelial cell of the paranasal region of the viscerocranial mucosa." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002651 ; owl:annotatedTarget "An endothelial cell that is part of the venous sinus of spleen. This endothelial cell has an elongated, spindle-shaped, flattened morphology that is parallel to long axis of sinus. This cell type rests on a basement membrane interrupted by numerous narrow slits." . [] oboInOwl:hasDbXref "FMA:62817" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002651 ; owl:annotatedTarget "stave cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000025 ; owl:annotatedTarget obo:CL_0000675 . [] a owl:Axiom ; rdfs:label "smooth muscle cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000192 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000192" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20726857" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002652 ; owl:annotatedTarget "A venule endothelial cell that is cubodial, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002653 ; owl:annotatedTarget "A squamous shaped endothelial cell." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002654 ; owl:annotatedTarget "An epithelial cell of stratum corneum of esophageal epithelium." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002655 ; owl:annotatedTarget "An epithelial cell of stratum spinosum of esophageal epithelium." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:25023676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002656 ; owl:annotatedTarget "A glandular epithelial cell of the endometrium. Following ovulation, these cells secrete a glycogen-rich substance known as histotroph or uterine milk, which nourishes the embryo if implantation occurs." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002657 ; owl:annotatedTarget obo:CL_0000150 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002657 ; owl:annotatedTarget obo:CL_0002252 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002657 ; owl:annotatedTarget "A glandular epithelial cell of the esophagus." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002658 ; owl:annotatedTarget obo:CL_0000150 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002658 ; owl:annotatedTarget "A glandular epithelial cell of the large intestine." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002659 ; owl:annotatedTarget "A glandular epithelial cell that is part of the stomach." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002660 ; owl:annotatedTarget "A luminal epithelial cell of mammary gland located in acinus of structure." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002661 ; owl:annotatedTarget "A luminal cell of terminal ducts, i.e.e the terminal branch of a lactiferous duct which alveolar cells drain into." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19022771" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002662 ; owl:annotatedTarget "A luminal epithelial cell of the lactiferous duct. This cuboidal epithelial cell expresses keratin-18 and is estrogen-receptor alpha positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002663 ; owl:annotatedTarget obo:CL_0002074 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002663 ; owl:annotatedTarget "A myocardial endocrine cell that is part of the atrium." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19745164" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002664 ; owl:annotatedTarget "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." . [] oboInOwl:hasDbXref "PMID:17519333", "PMID:19745164" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002664 ; owl:annotatedTarget "cardiovascular progenitor cell" . [] oboInOwl:hasDbXref "PMID:19745164" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002664 ; owl:annotatedTarget "CPC" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18353863" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002665 ; owl:annotatedTarget "A fibrocyte of the cochlea that has specialized structural and molecular adaptions." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18353863" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002666 ; owl:annotatedTarget "An otic fibrocyte that underlies the spiral prominence and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." . [] oboInOwl:hasDbXref "MP:0004488" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002666 ; owl:annotatedTarget "type II spiral ligament fibrocyte" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18353863" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002667 ; owl:annotatedTarget "An otic fibrocyte that resides above the stria vasularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18353863" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002668 ; owl:annotatedTarget "An otic fibrocyte that is lateral to the basilar membrane and anchoris it to the lateral wall." . [] oboInOwl:hasDbXref "MP:0004490" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002668 ; owl:annotatedTarget "type IV spiral ligament fibrocyte" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18353863" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002669 ; owl:annotatedTarget "An otic fibrocyte that lines the otic capsule." . [] oboInOwl:hasDbXref "MP:0004489" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002669 ; owl:annotatedTarget "type III spiral ligament fibrocyte" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18353863" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002670 ; owl:annotatedTarget "An otic fibrocyte that underlies the stria vascularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." . [] oboInOwl:hasDbXref "MP:0004487" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002670 ; owl:annotatedTarget "type I spiral ligament fibrocyte" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:21521739" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002671 ; owl:annotatedTarget "An endothelial stalk cell is a specialized endothelial cell that follows behind the tip cell of an angiogenic sprout." . [] oboInOwl:hasDbXref "DOI:10.1007/s12079-019-00511-z", "DOI:10.1016/j.cmet.2013.08.001", "DOI:10.1101/cshperspect.a006569", "DOI:10.3389/fcell.2021.642352" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002671 ; owl:annotatedTarget """Endothelial stalk cells are specialized vascular cells vital in angiogenesis, a process through which new blood vessels are formed from pre-existing ones; specifically, endothelial stalk cells are involved in sprouting angiogenesis, where they help form the body of new blood vessels. Vascular sprouting relies on the coordinated activity of migrating endothelial tip cells at the forefront and proliferating stalk cells that elongate the sprout. The process is tightly controlled by different growths factors: Vascular Endothelial Growth Factor acts on endothelial cells, inducing them to become endothelial tip cells that initiate sprouting. After sprouting initiation, activation of Notch signaling suppresses differentiation toward a tip cell phenotype and some of the endothelial cells differentiate into stalk cells, which follow tip cells, multiply, and elongate to provide a structural backbone to the growing vessel sprout. In contrast to endothelial tip cells, which migrate and lead the angiogenic sprout, endothelial stalk cells behind the sprouts continue forming the tube or lumen for blood flow and facilitate maturation and stability of the new vessel. The delicate balance between the activities of stalk and tip cells during angiogenesis is crucial to build a functional vascular network. Dysfunctions in endothelial stalk cells can lead to pathological conditions such as impaired wound healing, unregulated tumor growth, and metastasis due to abnormal angiogenesis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "MESH:D032383" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000193 ; owl:annotatedTarget "A striated muscle cell of an arthropod heart that participates in heart contraction." . [] a owl:Axiom ; rdfs:label "endothelial stalk cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002671 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002671" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20959166", "PMID:21148186" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002672 ; owl:annotatedTarget "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18816858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002673 ; owl:annotatedTarget "A skeletal muscle cell that is part of the tongue." . [] oboInOwl:hasDbXref "DOI:10.1002/ca.21011", "https://www.ncbi.nlm.nih.gov/books/NBK507782/", "https://www.ncbi.nlm.nih.gov/books/NBK554405/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002673 ; owl:annotatedTarget """Tongue muscle cells are responsible for essential functions like mastication, deglutition (swallowing), phonation (speech), and taste receptivity. They can be classified into two functional classes - extrinsic and intrinsic muscle cells. The extrinsic tongue muscle cells originate outside the tongue and are primarily involved in determining the position of the tongue within the mouth. Muscle groups such as the genioglossus, hyoglossus, and styloglossus are composed of these extrinsic muscle cells and grant the tongue its wide range of motion. The intrinsic tongue muscle cells, on the other hand, originate and function within the tongue itself, influencing the shape of the tongue during speech, eating, and swallowing. These cells can contract to alter the tongue's shape, making it long, short, curled, or flat, as needed. Together, these two types of muscle cells allow the tongue to perform its vital functions effectively. Moreover, they play a critical role in maintaining oral health by facilitating physical cleaning of the oral cavity and assisting in the mechanical breakdown of food. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "doi:10.2142/biophysics.7.21" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000196 ; owl:annotatedTarget "A muscle cell that is involved in the mechanism of insect flight. This encompasses both, cells that power flight and cells that control flight." . [] a owl:Axiom ; rdfs:label "tongue muscle cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002673 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002673" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002674 ; owl:annotatedTarget "A S. pombe mating type determined by the mat1-Mc and mat1-Mi on the mat1 locus." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002675 ; owl:annotatedTarget "A S. pombe cell type determined by mat1-Pc and mat1-Pi on the mat1 locus." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:17407019" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002676 ; owl:annotatedTarget "A neuroblast derived from a neural crest cell." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002677 ; owl:annotatedTarget "A regulatory T cell that has not encountered antigen." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000196 ; owl:annotatedTarget "FBbt:00003360" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:21739668" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002678 ; owl:annotatedTarget "A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000025 ; owl:annotatedTarget "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002679 ; owl:annotatedTarget obo:CL_0000542 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20023630" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002679 ; owl:annotatedTarget "A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002680 ; owl:annotatedTarget obo:CL_0000696 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:2420136", "PMID:728970" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002680 ; owl:annotatedTarget "A PP cell found in intestine." . [] oboInOwl:hasDbXref "PMID:11978858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003002 ; owl:annotatedTarget "A retinal ganglion cell that has a small dendritic field and a medium dendritic arbor with post sympatic terminals in sublaminar layer S3." . [] oboInOwl:hasDbXref "PMID:11978858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003003 ; owl:annotatedTarget "A mono-stratified retinal ganglion cell that has a small dendritic field and a sparse dendritic arbor with post sympatic terminals in sublaminar layer S3." . [] oboInOwl:hasDbXref "PMID:11978858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003004 ; owl:annotatedTarget "A bistratified retinal ganglion cell that has a small dendritic field with sparse density that terminates at the intersection of the S4-S5 sublaminar level, and a second dendrite field that is medium in size and degree of arborization that terminates in sublaminar layer S2." . [] oboInOwl:hasDbXref "PMID:11978858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003006 ; owl:annotatedTarget "A G4 retinal ganglion cell that has post sympatic terminals in sublaminar layers S3 and S4 and is depolarized by illumination of its receptive field center." . [] oboInOwl:hasDbXref "PMID:11978858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003008 ; owl:annotatedTarget "A mono-stratified retinal ganglion cell that has a medium dendritic field and a medium dendritic arbor with post sympatic terminals in sublaminar layer S2." . [] oboInOwl:hasDbXref "PMID:11978858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003009 ; owl:annotatedTarget "A mono-stratified retinal ganglion cell that has a medium dendritic field and a sparse dendritic arbor with post sympatic terminals in sublaminar layer S4 and S5." . [] oboInOwl:hasDbXref "PMID:11978858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003010 ; owl:annotatedTarget "A bistratified retinal ganglion cell that has a dendrite field that terminates in sublaminar layer S2 and a second dendrite field that terminates in sublaminar layer S4." . [] oboInOwl:hasDbXref "PMID:11978858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003011 ; owl:annotatedTarget "A mono-stratified retinal ganglion cell that has a large dendritic field and a sparse dendritic arbor with post synaptic terminals in sublaminar layer S4." . [] oboInOwl:hasDbXref "PMID:11978858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003012 ; owl:annotatedTarget "A mono-stratified retinal ganglion cell that has a large dendritic field and a medium dendritic arbor with post synaptic terminals in sublaminar layer S1 and S2." . [] oboInOwl:hasDbXref "PMID:11978858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003013 ; owl:annotatedTarget "A mono-stratified retinal ganglion cell that has a large dendritic field, a medium dendritic arbor, and a long secondary dendrite shaft with post synaptic terminals in sublaminar layer S4." . [] oboInOwl:hasDbXref "PMID:11978858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003014 ; owl:annotatedTarget "A mono-stratified retinal ganglion cell that has a large dendritic field, a medium dendritic arbor, and a medium length secondary dendrite shaft." . [] oboInOwl:hasDbXref "MESH:D009619" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000198 ; owl:annotatedTarget "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings." . [] oboInOwl:hasDbXref "PMID:11978858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003015 ; owl:annotatedTarget "A G11 retinal ganglion cell that has post synaptic terminals in sublaminar layer S4 and is depolarized by illumination of its receptive field center." . [] oboInOwl:hasDbXref "PMID:11978858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003016 ; owl:annotatedTarget "A G11 retinal ganglion cell that has post synaptic terminals in sublaminar layer S2 and is depolarized by decreased illumination of their receptive field center" . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003017 ; owl:annotatedTarget "A retinal ganglion B cell that has post synaptic terminals in S2." . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003018 ; owl:annotatedTarget "A retinal ganglion B3 cell with dentrites terminating in S4." . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003020 ; owl:annotatedTarget "A retinal ganglion cell C that has post-synaptic terminals in S2." . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003021 ; owl:annotatedTarget "A retinal ganglion cell C outer that has a medium dendritic field and a dense dendritic arbor." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000198 ; owl:annotatedTarget "ZFA:0009119" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003022 ; owl:annotatedTarget "A retinal ganglion cell C outer that has medium dendritic density and field size." . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003023 ; owl:annotatedTarget "A retinal ganglion cell C outer that has dense dendritic diversity." . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003024 ; owl:annotatedTarget "A retinal ganglion cell C with medium cell bodies and large dendritic field." . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003025 ; owl:annotatedTarget "A retinal ganglion cell C inner that has sparse dendritic density, and large dendritic field." . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003026 ; owl:annotatedTarget "A bistratified retinal ganglion cell that has a small dendrite fields with a sparse dendrite arbor terminating in S2 and S3." . [] a owl:Axiom ; rdfs:seeAlso "https://meshb.nlm.nih.gov/record/ui?ui=D009619"^^xsd:anyURI ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000198 ; owl:annotatedTarget "nociceptor" . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003027 ; owl:annotatedTarget "A bistratified retinal ganglion cell D cell that has medium dendritic arbor and a large dendritic field that terminates in S2 and S4." . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003028 ; owl:annotatedTarget "A monostratified retinal ganglion cell that has a small dendrite field with a dense dendrite arbor with post synaptic terminals in sublaminer layer S4." . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003029 ; owl:annotatedTarget "A monostratified retinal ganglion cell that has a small soma, a small dendrite field with a dense dendrite arbor, and post synaptic terminals in sublaminer layer S2 and S3." . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003030 ; owl:annotatedTarget "A monostratified retinal ganglion cell that has a medium soma and a small dendrite field." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000025 ; owl:annotatedTarget "FBbt:00057012" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:seeAlso "https://www.thefreedictionary.com/nocireceptor"^^xsd:anyURI ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000198 ; owl:annotatedTarget "nocireceptor" . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003031 ; owl:annotatedTarget "A monostratified retinal ganglion cell that has post synaptic terminals in sublaminar layer S4 and is depolarized by illumination of its receptive field center." . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003032 ; owl:annotatedTarget "A monostratified retinal ganglion cell that has post synaptic terminals in sublaminar layer S2 and is depolarized by decreased illumination of their receptive field center" . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003033 ; owl:annotatedTarget "A monostratified retinal ganglion cell that has a large soma, a medium dendritic field with post synaptic terminals in sublaminar layer S3." . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003034 ; owl:annotatedTarget "A monostratified retinal ganglion cell that has a small soma, an assymetric dendritic field with post synaptic terminals in sublaminar layer S3." . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003035 ; owl:annotatedTarget "A monostratified retinal ganglion cell that contains opsin." . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003036 ; owl:annotatedTarget "A monostratified retinal ganglion cell with large soma and large dendritic field, with medium dendritic arbor, and has dendrites in layers 2 and 5." . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003037 ; owl:annotatedTarget "An M7 retinal ganglion cells with synaptic terminals in S4 and is depolarized by illumination of its receptive field center." . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003038 ; owl:annotatedTarget "An M7 retinal ganglion cells with synaptic terminals in S2 and is depolarized by decreased illumination of their receptive field center" . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003039 ; owl:annotatedTarget "A monostratified retinal ganglion cell with large soma and medium dendritic field, with dense dendritic arbor." . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003040 ; owl:annotatedTarget "A monostratified retinal ganglion cell with large soma and large dendritic field, with medium dendritic arbor, and has dendrites in layers 1 and 5." . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003041 ; owl:annotatedTarget "An M9 retinal ganglion cells with synaptic terminals in S2 and is depolarized by illumination of its receptive field center." . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003042 ; owl:annotatedTarget "An M9 retinal ganglion cell with synaptic terminals in S4 that is depolarized by decreased illumination of their receptive field center" . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003043 ; owl:annotatedTarget "A monostratified retinal ganglion cell with large soma and large dendritic field, with dense dendritic arbor." . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003044 ; owl:annotatedTarget "A bistratified ganglion cell with small, dense dendritic fields that terminate in S1 and S3." . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003045 ; owl:annotatedTarget "A bistratified ganglion cell with larger, asymetric dendritic fields that terminate in S2 and S4." . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003046 ; owl:annotatedTarget "A bistratifed retinal ganglion cell that has small, symmetric dendritic fields that terminate in S2 and S4." . [] oboInOwl:hasDbXref "PMID:16626866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003047 ; owl:annotatedTarget "A bistratifed retinal ganglion cell that has small, symmetric dendritic fields that terminate in S1 and S4-S5." . [] oboInOwl:hasDbXref "WikipediaVersioned:Cone_cell&oldid=1111888680" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003048 ; owl:annotatedTarget "A cone cell that detects long wavelength light. Exact peak of spectra detected differs between species. In humans, spectra peaks at 564-580 nm." . [] oboInOwl:hasDbXref "PMID:32555229" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003048 ; owl:annotatedTarget "L cone" . [] oboInOwl:hasDbXref "PMID:29603924" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003048 ; owl:annotatedTarget "L-cone" . [] oboInOwl:hasDbXref "PMID:31117170" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003048 ; owl:annotatedTarget "long wavelength sensitive cone" . [] oboInOwl:hasDbXref "https://doi.org/10.7554/eLife.39166" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003048 ; owl:annotatedTarget "long- (L) wavelength-sensitive cone" . [] oboInOwl:hasDbXref "https://doi.org/10.1038/323623a0" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003048 ; owl:annotatedTarget "long-wavelength cone" . [] oboInOwl:hasDbXref "WikipediaVersioned:Cone_cell&oldid=1111888680" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003049 ; owl:annotatedTarget "A cone cell that detects medium wavelength light. Exact peak of spectra detected differs between species. In humans, spectra peaks at 534-545 nm." . [] oboInOwl:hasDbXref "PMID:32555229" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003049 ; owl:annotatedTarget "M cone" . [] oboInOwl:hasDbXref "PMID:29603924" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003049 ; owl:annotatedTarget "M-cone" . [] oboInOwl:hasDbXref "PMID:31117170" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003049 ; owl:annotatedTarget "middle wavelength sensitive cone" . [] oboInOwl:hasDbXref "https://doi.org/10.7554/eLife.39166" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003049 ; owl:annotatedTarget "middle- (M) wavelength-sensitive cone" . [] oboInOwl:hasDbXref "https://opg.optica.org/josaa/abstract.cfm?URI=josaa-6-1-153" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003049 ; owl:annotatedTarget "middle-wavelength-sensitive (M) cone" . [] oboInOwl:hasDbXref "WikipediaVersioned:Cone_cell&oldid=1111888680" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0003050 ; owl:annotatedTarget "A cone cell that detects short wavelength light. Exact peak of spectra detected differs between species. In humans, spectra peaks at 420-440 nm." . [] oboInOwl:hasDbXref "PMID:32555229" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003050 ; owl:annotatedTarget "S cone" . [] oboInOwl:hasDbXref "PMID:31117170" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003050 ; owl:annotatedTarget "S-(short-wavelength sensitive) cone" . [] oboInOwl:hasDbXref "PMID:32555229" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003050 ; owl:annotatedTarget "S-cone" . [] oboInOwl:hasDbXref "https://doi.org/10.7554/eLife.39166" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003050 ; owl:annotatedTarget "S-cone photoreceptor" . [] oboInOwl:hasDbXref "MESH:D008465" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000199 ; owl:annotatedTarget "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." . [] oboInOwl:hasDbXref "PMID:31117170" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003050 ; owl:annotatedTarget "short wavelength sensitive cone" . [] oboInOwl:hasDbXref "https://doi.org/10.7554/eLife.39166" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003050 ; owl:annotatedTarget "short- (S) wavelength-sensitive cone" . [] oboInOwl:hasDbXref "PMID:31117170" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003050 ; owl:annotatedTarget "short-wavelength sensitive cone" . [] oboInOwl:hasDbXref "https://opg.optica.org/josaa/abstract.cfm?URI=josaa-6-1-153" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0003050 ; owl:annotatedTarget "short-wavelength-sensitive (S) cone" . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004115 ; owl:annotatedTarget "A monostratified retinal ganglion cell with small to medium soma and small to medium dendritic field." . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004116 ; owl:annotatedTarget "A retinal ganglion with cell medium cell bodies and medium to large dendritic fields." . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004117 ; owl:annotatedTarget "A monostratified retinal ganglion cell with large soma and large dendritic field." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000199 ; owl:annotatedTarget "ZFA:0009120" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004119 ; owl:annotatedTarget "A retinal ganglion cell B that has medium body size, medium dendritic field and dense dendritic arbor, and has post synaptic terminals in S2." . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0004119 ; owl:annotatedTarget "Could not distingush between B1 and B4 from paper." . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004120 ; owl:annotatedTarget "A retinal ganglion A cell found in the retina with large somata, often polygonal in shape. The dendritic fields consist of three to seven stout dendrites that are sparce near soma. Dendrites terminate in S4." . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004121 ; owl:annotatedTarget "A retinal ganglion cell B that has a very small but very dense dendritic field, and has post synaptic terminals in S2." . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004124 ; owl:annotatedTarget "A retinal ganglion cell C inner that has medium dendritic diversity." . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004125 ; owl:annotatedTarget "A retinal ganglion cell C inner that has dense dendritic diversity." . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004126 ; owl:annotatedTarget "A retinal ganglion cell C outer that has symmetrical and dense dendritic dendritic tree with a large dendritic field." . [] oboInOwl:hasDbXref "MP:0000972" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000199 ; owl:annotatedTarget "mechanoreceptor" . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004137 ; owl:annotatedTarget "A retinal ganglion A2 cell with dendrites terminating in S4." . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004138 ; owl:annotatedTarget "A retinal ganglion A cell with dense arbor near soma." . [] oboInOwl:hasDbXref "PMID:12209831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004139 ; owl:annotatedTarget "A retinal ganglion A2 cell with dendrites terminating in S2." . [] a owl:Axiom ; rdfs:label "MB" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0004161 ; owl:annotatedTarget "BAMS:1028" . [] a owl:Axiom ; rdfs:label "MB" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0004162 ; owl:annotatedTarget "BAMS:1029" . [] oboInOwl:hasDbXref "PMID:19129389" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004213 ; owl:annotatedTarget "A type of type 3 cone bipolar cell with distinctive curly dendrites." . [] oboInOwl:hasDbXref "PMID:19129389" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004214 ; owl:annotatedTarget "A type of type 3 cone bipolar cell with distinctive crescent-shaped dendrites." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000025 ; owl:annotatedTarget "ZFA:0001570" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:8571130" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004217 ; owl:annotatedTarget "A horizontal cell with a large cell body, thick dendrites, and a large dendritic arbor." . [] oboInOwl:hasDbXref "doi:10.1038/s41598-020-66092-9" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0004217 ; owl:annotatedTarget "H1" . [] oboInOwl:hasDbXref "PMID:8571130" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004218 ; owl:annotatedTarget "A horizontal cell with a small cell body, thin dendrites, and small dendritic arbor." . [] oboInOwl:hasDbXref "doi:10.1038/s41598-020-66092-9" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0004218 ; owl:annotatedTarget "H2" . [] oboInOwl:hasDbXref "PMID:24246263", "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004219 ; owl:annotatedTarget "A bistratifed retinal amacrine cell with a small dendritic field, dendrite stratification in S1-S2, and a second dendrite stratification in S5. This cell type releases the neurotransmitter glycine." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004220 ; owl:annotatedTarget "An amacrine cell with a small, asymteric dendritic field." . [] oboInOwl:hasDbXref "PMID:24246263", "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004221 ; owl:annotatedTarget "A flag amacrine cell with post-synaptic terminals in S2 and S3. This cell type releases the neurotransmitter glycine." . [] oboInOwl:hasDbXref "PMID:24246263", "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004222 ; owl:annotatedTarget "A flag amacrine cell with post-synaptic terminals in S3, S4, and S5. This cell type releases the neurotransmitter glycine." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004223 ; owl:annotatedTarget "A amacrine cell with a small dendritic field and post-synaptic terminals in S1, S2, S3, and S4. AB diffuse-1 amacrine cells have a tent-shaped dendritic arbor and undulate dendrites." . [] oboInOwl:hasDbXref "PMID:32032773", "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004224 ; owl:annotatedTarget "A broadly stratifying amacrine cell that has a small dendritic field and post-synaptic terminals in S2 and S3. This cell type releases the neurotransmitter glycine." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004225 ; owl:annotatedTarget "A broadly stratifying amacrine cell with a small dendritic field, straight dendrites and post-synaptic terminals in S1, S2, and S3." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004226 ; owl:annotatedTarget "An amacrine cell with a small dendritic field with post-synaptic terminals in S3 and S4." . [] oboInOwl:hasDbXref "PMID:25630271", "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004227 ; owl:annotatedTarget "A bistratified amacrine cell with a small dendritic field. Flat bistratified amacrine cells have post-synaptic terminals both on the border of S1 and S2, and on the border of S3 and S4. This cell type releases the neurotransmitter glycine." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000200 ; owl:annotatedTarget "Any neuron that is capable of some detection of mechanical stimulus involved in sensory perception of touch." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004228 ; owl:annotatedTarget "An amacrine cell with a small dendritic field that has post-synaptic terminals in S1, S2, S3, and S4." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004229 ; owl:annotatedTarget "A bistratified amacrine cell with a small dendritic field that has dendrite stratification in S2, and in S3 and S4." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004230 ; owl:annotatedTarget "A bistratified amacrine cell with a small dendritic field that has post-synaptic terminals in S1 and the border of S1-S2, and termination of a second arbor within the border of S2-S3 and S3." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004231 ; owl:annotatedTarget "A broadly stratifying amacrine cell with a small dendritic field and a complex dendritic arbor. Recurving diffuse amacrine cells have post-synaptic terminals in S2, S3, and S4." . [] oboInOwl:hasDbXref "PMID:32032773", "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004232 ; owl:annotatedTarget "An amacrine cell with a flat dendritic arbor and a medium dendritic field. Starburst amacrine cells have post-synaptic terminals in S2. This cell type releases the neurotransmitters gamma-aminobutyric acid (GABA) and acetylcholine." . [] oboInOwl:hasDbXref "PMID:9194315" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004233 ; owl:annotatedTarget "An amacrine cell with a medium dendritic field and post-synaptic terminals that stratify at S2, with a second stratification that occurs in S3 and S4. This cell type releases the neurotransmitter glycine." . [] oboInOwl:hasDbXref "MESH:D006198", "WikipediaVersioned:Hair_cell&oldid=1045345915" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000202 ; owl:annotatedTarget "A mechanoreceptor cell of the auditory or vestibular system that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004234 ; owl:annotatedTarget "An amacrine cell with a medium dendritic field and post-synaptic terminals in S2, and in S3-S4." . [] oboInOwl:hasDbXref "PMID:32032773", "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004235 ; owl:annotatedTarget "An amacrine cell with a medium dendritic field and post-synaptic terminals in S2 and S3. This cell type releases the neurotransmitter gamma-aminobutyric acid (GABA)." . [] oboInOwl:hasDbXref "PMID:32032773", "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004236 ; owl:annotatedTarget "An amacrine cell with a medium dendritic field and post-synaptic terminals in S2, S3, and S4. This cell type releases the neurotransmitter gamma-aminobutyric acid (GABA)." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000202 ; owl:annotatedTarget "ZFA:0009121" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:10614594", "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004237 ; owl:annotatedTarget "A retinal amacrine cell with a medium dendritic field and post-synaptic terminals in S1, S2, S3, and S4. This cell type releases the neurotransmitter gamma-aminobutyric acid (GABA)." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004238 ; owl:annotatedTarget "A bistratified amacrine cell with a medium dendritic field, a flat and sparse dendritic arbor, and post-synaptic terminals at the intersections of S1 and S2, and S3 and S4." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004239 ; owl:annotatedTarget "A bistratified amacrine cell with a medium dendritic field and post-synaptic terminals in S1-S2, and S4." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004240 ; owl:annotatedTarget "An amacrine cell with a wide dendritic field, dendrites in S1, and post-synaptic terminals in S1." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004241 ; owl:annotatedTarget "An amacrine cell with a wide dendritic field, dendrites in S2, and post-synaptic terminals in S1." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004242 ; owl:annotatedTarget "An amacrine cell with a wide dendritic field, dendrites in S3, and post-synaptic terminals in S3. Dendrites of this cell type are straight and minimally branched." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004243 ; owl:annotatedTarget "An amacrine cell with a wild dendritic field, dendrites in S3, and post-synaptic terminals in S3. Dendrites have spikes, cross over each other, and cover a larger volume than dendrties of W3-1 retinal amacrine cells." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004244 ; owl:annotatedTarget "An amacrine cell with a wide dendritic field, dendrites in S4, and post-synaptic terminals in S4." . [] oboInOwl:hasDbXref "PMID:12486181", "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004245 ; owl:annotatedTarget "An amacrine cell with a wide dendritic field and post-synaptic terminals in S5. This cell type releases the neurotransmitters gamma-aminobutyric acid (GABA) and serotonin." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004246 ; owl:annotatedTarget "A central nervous system neuron that stratifies at one and only one location." . [] oboInOwl:hasDbXref "PMID:9620701", "https://orcid.org/0000-0002-5260-9315" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004247 ; owl:annotatedTarget "A neuron that stratifies dendrites at two and only two locations." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004250 ; owl:annotatedTarget "An amicrine that stratifies dendrites at two and only two locations." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004251 ; owl:annotatedTarget "An amicrine that has a narrow dendritic field." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004252 ; owl:annotatedTarget "An amicrine that has a medium dendritic field." . [] oboInOwl:hasDbXref "PMID:9620701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0004253 ; owl:annotatedTarget "An amicrine that has a wide dendritic field." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0005000 ; owl:annotatedTarget obo:CL_0000099 . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005000 ; owl:annotatedTarget "A CNS interneuron located in the spinal cord." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005000 ; owl:annotatedTarget "ZFA:0000778" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005001 ; owl:annotatedTarget "A non-terminally differentiated cell that originates from the neural crest and differentiates into an iridophore." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005001 ; owl:annotatedTarget "ZFA:0005328" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005002 ; owl:annotatedTarget "A non-terminally differentiated cell that differentiates into a xanthophore." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005002 ; owl:annotatedTarget "ZFA:0005245" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000203 ; owl:annotatedTarget "Any neuronal receptor cell that is capable of some detection of mechanical stimulus involved in sensory perception of gravity." . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005003 ; owl:annotatedTarget "A non-terminally differentiated cell that originates from the neural crest and differentiates into a leucophore." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005003 ; owl:annotatedTarget "ZFA:0005329" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005004 ; owl:annotatedTarget "A non-terminally differentiated cell that originates from the neural crest and differentiates into an erythrophore." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005004 ; owl:annotatedTarget "ZFA:0005331" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005005 ; owl:annotatedTarget "A non-terminally differentiated cell that originates from the neural crest and differentiates into a cyanophore." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005005 ; owl:annotatedTarget "ZFA:0005332" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:17555741", "PMID:19268451" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005006 ; owl:annotatedTarget "Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment." . [] oboInOwl:hasDbXref "DOI:10.1016/j.jcf.2019.09.010", "DOI:10.1038/s41586-018-0393-7", "DOI:10.1038/s41598-023-30603-1", "DOI:10.1146/annurev-pathol-042420-094031", "DOI:10.3389/fmars.2020.00709" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0005006 ; owl:annotatedTarget """Ionocytes are specialized cells predominantly found in the mammalian respiratory and renal systems as well as in the gills, skin, and intestinal tract of fish. These cells play crucial roles in maintaining ion and acid-base homeostasis. Ionocytes demonstrate remarkable plasticity and are able to adapt themselves in response to changes in environmental conditions such as pH, salinity, ion concentration, and temperature. These cells work by selectively absorbing specific ions from the environment, thus maintaining the body's internal ionic balance. The most commonly absorbed ions include sodium (Na+), chloride (Cl-), calcium (Ca2+), and hydrogen (H+). Moreover, ionocytes contribute to acid-base regulation. In response to acidosis or alkalosis, ionocytes can either excrete or retain hydrogen (H+) and bicarbonate (HCO3-) ions to readjust the blood pH. Further, experimental evidence suggests a functional complexity of ionocytes, implying diverse roles beyond ion regulation. Recent research highlights ionocytes' involvement in ammonia excretion and the regulation of extracellular fluid volume, highlighting their contribution to the overall homeostatic process. Malfunctioning ionocytes have been implicated in various diseases, including cystic fibrosis which is caused by mutations in the chloride channel CFTR, an ionocyte marker. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005006 ; owl:annotatedTarget "ZFA:0005323" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "ionocyte on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0005006 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0005006" . [] oboInOwl:hasDbXref "PMID:18680739" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005007 ; owl:annotatedTarget "Kolmer-Agduhr neurons are ciliated GABAergic neurons that contact the central canal of the spinal cord and have ipsilateral ascending axons." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005007 ; owl:annotatedTarget "ZFA:0005240" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:15539490" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0005007 ; owl:annotatedTarget "KA interneuron" . [] oboInOwl:hasDbXref "PMID:9634146" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0005007 ; owl:annotatedTarget "KA neuron" . [] oboInOwl:hasDbXref "GO:cvs" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005008 ; owl:annotatedTarget "An auditory hair cell located in the macula that is sensitive to auditory stimuli." . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005009 ; owl:annotatedTarget "A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the apical membrane of the cell is regulated by aldosterone and vasopressin. In mammals this cell type is located in the renal collecting duct system." . [] oboInOwl:hasDbXref "DOI:10.1016/j.krcp.2013.07.005", "DOI:10.2215/CJN.05760513", "DOI:10.2215/CJN.08580813" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0005009 ; owl:annotatedTarget """Renal principal cells are the major cell type in the initial collecting tubule and the cortical and outer medullary collecting ducts, as well as the connecting tubule, in the nephrons of the kidneys. A key function of renal principal cells is the regulation of water balance in the body. These cells express aquaporin-2 (AQP2) water channels, which facilitate the reabsorption of water from the fluid within the renal tubule lumen back into the blood. The translocation of AQP2 to the cell membrane is controlled by the hormone vasopressin: In response to high vasopressin levels, AQP2 moves to the cell membrane, allowing water to pass through effectively and be reabsorbed, therefore concentrating the urine. Conversely, in low vasopressin conditions, AQP2 is removed from the membrane, reducing water reabsorption and diluting the urine. Renal principal cells are also involved in the regulation of sodium and potassium levels in the body. They have sodium channels (ENaC) in their luminal membranes which permit the reabsorption of sodium ions from the tubule fluid back into the blood, resulting in a net reabsorption of sodium ions into the systemic circulation. This process is controlled, in part, by the hormone aldosterone. Additionally, renal principal cells contain potassium channels that facilitate the secretion of potassium ions into the urine. The activities of these channels, in coordination with other cell types in the nephron, are critical for maintaining electrolyte balance and overall body homeostasis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005009 ; owl:annotatedTarget "ZFA:0005322" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "renal principal cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0005009 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0005009" . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005010 ; owl:annotatedTarget "A cuboidal epithelial cell of the kidney that regulates acid/base balance." . [] oboInOwl:hasDbXref "DOI:10.1152/ajprenal.2000.279.1.F195", "DOI:10.1161/HYPERTENSIONAHA.121.16492", "DOI:10.1681/ASN.V1011", "DOI:10.2215/CJN.08880914" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0005010 ; owl:annotatedTarget """Renal intercalated cells are specialized cells located in the collecting duct system of the kidneys. The primary role of intercalated cells is to reabsorb bicarbonate ions and secrete hydrogen ions, thereby maintaining the acid-base homeostasis in the blood. They comprise two main subtypes primarily distinguished by their functional and morphological attributes: alpha and beta intercalated cells. Alpha intercalated cells are more predominant when the body is in a state of acidosis, a condition characterized by an increased acidity of the blood. These cells are specialized in secreting excessive hydrogen ions into the urine through a mechanism involving vacuolar H+-ATPase and H+/K+-ATPase pumps on their apical membranes. They simultaneously reabsorb bicarbonate ions from the tubular fluid and return them to the bloodstream via mechanisms involving carbonic anhydrase II and bicarbonate/chloride exchangers on the basolateral membrane. This dual process helps to increase blood pH towards normal levels. When the body is in a state of alkalosis, a condition characterized by lowered levels of hydrogen ions in the blood, beta intercalated cells are more predominant. They primarily reabsorb hydrogen ions from the tubular fluid through vacuolar H+-ATPase and H+/K+-ATPase pumps on their basolateral membranes, while secreting bicarbonate ions into the urine via pendrin, a bicarbonate/chloride exchanger in the apical membrane. These mechanisms work together to decrease blood pH towards normal levels. In summary, renal intercalated cells play a critical role in the delicate balance of the body’s pH, safeguarding the body from potential harm caused by acidemia or alkalemia. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005010 ; owl:annotatedTarget "ZFA:0009375" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:25632105" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0005010 ; owl:annotatedTarget "Intercalated cells are also called “mitochondria-rich cells”, reflecting the high levels of round mitochondria at their apical pole, or in their cytoplasm, a distribution that is quite different from that of other kidney tubule cells, which accumulated mitochondria around the basolateral membrane. These cells also have numerous irregular apical microvilli compared with the surrounding segment-specific cells. Intercalated cells lack a central cilium, at least in the cortex, which also differentiates them from the adjacent principal cells." . [] a owl:Axiom ; rdfs:label "renal intercalated cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0005010 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0005010" . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005011 ; owl:annotatedTarget "A cuboidal epithelial cell of the kidney which secretes acid and reabsorbs base to regulate acid/base balance." . [] oboInOwl:hasDbXref "DOI:10.1016/j.semnephrol.2019.04.005", "DOI:10.1152/physiol.00008.2011", "DOI:10.1172/JCI63492", "DOI:10.3390/diseases2020071" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0005011 ; owl:annotatedTarget """Renal alpha-intercalated cells are located within the connecting tubules and collecting ducts of the kidneys, which are components of the kidney's complex nephron system. Along with beta-intercalated cells, they play a critical role in the body’s acid-base balance. Renal alpha-intercalated cells contain an abundance of proton pumps and enzymes like carbonic anhydrase, which aid in the transport of hydrogen ions for secretion in the urine. The bicarbonate/chloride transporters on their apical membrane meanwhile take up bicarbonate ions from the urine and supply them back into the blood. Through this mechanism, these cells contribute significantly to the neutrality of blood pH, and dysfunction of renal alpha-intercalated cells often leads to distal renal tubular acidosis, a condition resulting in acidic blood and alkaline urine. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005011 ; owl:annotatedTarget "ZFA:0009376" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:25632105" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0005011 ; owl:annotatedTarget "type A intercalated cell" . [] oboInOwl:hasDbXref "PMID:25632105" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0005011 ; owl:annotatedTarget "type A-IC" . [] oboInOwl:hasDbXref "PMID:25632105" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0005011 ; owl:annotatedTarget "Type A intercalated cells are the more abundant type of intercalated cell in the outer stripe of the outer medulla in most mammalian species." . [] a owl:Axiom ; rdfs:label "renal alpha-intercalated cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0005011 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0005011" . [] oboInOwl:hasDbXref "CL:CVS", "PMID:28400610", "PMID:30422572", "PMID:38032388" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005012 ; owl:annotatedTarget "A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface." . [] oboInOwl:hasDbXref "DOI:10.1016/j.cub.2014.08.047", "DOI:10.1038/nrm.2017.21", "DOI:10.1101/cshperspect.a028233" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0005012 ; owl:annotatedTarget """The multi-ciliated epithelial cell are terminally differentiated epithelia that line brain ventricles, the respiratory tract and parts of the female and male reproductive organs in animals, playing critical roles in the maintenance of homeostasis through ciliary motion. They are characterized by the presence of hundreds of motile cilia, hair-like microtubule-based organelles that beat in a coordinated fashion to direct fluid flow over the cell surface. Multi-ciliated epithelial cells have fundamental roles in the proper functioning of many organ systems. In the respiratory system, they line the airways and orchestrate the coordinated movement of mucus, effectively clearing the airways of inhaled particles and pathogens. These cells are also vital in the ventricular system of the brain where they facilitate cerebrospinal fluid circulation, thus contributing to the maintenance of the brain's microenvironment. In the fallopian tube, multi-ciliated epithelial cells aid in the transport of oocytes from the ovary to the uterus, a process crucial to reproduction. The formation and function of multi-ciliated epithelial cells is a highly regulated process that involves several stages of development including cell specification, centriole multiplication, and ciliogenesis. Any disruption in these processes can result in dysfunctional or decreased numbers of cilia, which can lead to a myriad of health issues, ranging from chronic respiratory infections to infertility. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005012 ; owl:annotatedTarget "ZFA:0005242" ; sssom:mapping_justification . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0005012 ; owl:annotatedTarget "MCC"@en . [] oboInOwl:hasDbXref "PMID:22118931", "PMID:23959957", "PMID:25729351", "PMID:26378583" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0005012 ; owl:annotatedTarget "While the term 'multi-ciliated epithelial cell' refers to cells with multiple motile cilia, there are exceptions where epithelial cells may have multiple non-motile cilia. Examples include olfactory sensory neurons, which have non-motile cilia for sensory detection, and choroid plexus epithelial cells, which possess multiple non-motile cilia with transient motility during development. Multiciliated cells are essential for human health, and their dysfunction can lead to various diseases known as ciliopathies, such as primary ciliary dyskinesia. This condition affects the respiratory system, brain ventricles, and reproductive system, leading to chronic respiratory infections, hydrocephalus, and infertility" . [] a owl:Axiom ; rdfs:label "multiciliated epithelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0005012 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0005012" . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005013 ; owl:annotatedTarget "A ciliated epithelial cell with a single cilium." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005013 ; owl:annotatedTarget "ZFA:0005243" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "CL:CVS", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005014 ; owl:annotatedTarget "A non-sensory cell that extends from the basement membrane to the apical surface of the auditory epithelium and provides support for auditory hair cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005014 ; owl:annotatedTarget "ZFA:0005244" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005015 ; owl:annotatedTarget "An auditory epithelial support cell that surrounds the nerve fibers and synapses of the auditory inner hair cells." . [] oboInOwl:hasDbXref "TAIR:TB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005016 ; owl:annotatedTarget "Obsolete. Use PO:0030007 from Plant Ontology instead. The apical cell is the upper cell formed after the first division of a plant zygote." . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D013823", "MP:0000971" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000205 ; owl:annotatedTarget "A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain." . [] oboInOwl:hasDbXref "TAIR:TB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005017 ; owl:annotatedTarget "Obsolete. Use PO:0002002 from Plant Ontology instead. The lower cell formed after the first division of a plant zygote." . [] oboInOwl:hasDbXref "CL:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005018 ; owl:annotatedTarget "A cell that secretes ghrelin, the peptide hormone that stimulates hunger." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005018 ; owl:annotatedTarget "ZFA:0005599" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:15848391" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000026 ; owl:annotatedTarget "A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000205 ; owl:annotatedTarget "ZFA:0009123" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:14970313" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005019 ; owl:annotatedTarget "Ghrelin secreting cells found in the endocrine pancreas." . [] oboInOwl:hasDbXref "DOI:10.1007/s00125-008-1238-y", "DOI:10.1152/physrev.00012.2004", "DOI:10.1210/en.2018-00833", "DOI:10.3389/fendo.2022.904004", "DOI:10.3390/ijms20081867" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0005019 ; owl:annotatedTarget """Pancreatic epsilon cells are a specialized type of endocrine cell found in the islets of Langerhans, a region of the pancreas responsible for hormone production. These clusters of cells constitute only about 1% of the pancreatic islet cell population, making them a relatively small yet significant component of the pancreas. Pancreatic epsilon cells have a round or ovoid shape with occasional cytoplasmic extensions and are characterized by small and spherical granules. The principal function of pancreatic epsilon cells involves the synthesis and release of the hormone ghrelin, a peptide hormone predominantly produced in the stomach; pancreatic epsilon cells are one of the few sites outside the gastrointestinal tract known to produce this hormone. Ghrelin has multiple vital roles, playing a significant part in generating hunger sensations, promoting fat storage, and influencing various metabolic processes. It also stimulates the release of Growth Hormone (GH) from the anterior pituitary gland. During fetal development, when they form a layer around the islet, epsilon cells are an important source of ghrelin, likely secreting the hormone into the circulation; their numbers decrease in adults. While research on pancreatic epsilon cells is still ongoing, these cells have been implicated in several disease states, most notably Type 2 diabetes and metabolic syndrome. The dysfunction or reduction in the number of pancreatic epsilon cells can lead to anomalies in ghrelin production, impacting overall metabolic homeostasis and glucose regulation. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005019 ; owl:annotatedTarget "ZFA:0005598" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "pancreatic epsilon cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0005019 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0005019" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0005020 ; owl:annotatedTarget obo:CL_0000048 . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005020 ; owl:annotatedTarget "Lymphatic progenitor cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005020 ; owl:annotatedTarget "ZFA:0009393" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:15624319", "PMID:18430230" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005021 ; owl:annotatedTarget "Mesenchymal derived lymphatic progenitor cells that give rise to the superficial lymphatics." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005021 ; owl:annotatedTarget "ZFA:0009394" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0005022 ; owl:annotatedTarget obo:CL_0005020 . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005022 ; owl:annotatedTarget "Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005022 ; owl:annotatedTarget "ZFA:0009395" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ZFIN:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005023 ; owl:annotatedTarget "Cranial motor neuron which innervates muscles derived from the branchial (pharyngeal) arches." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005023 ; owl:annotatedTarget "ZFA:0005731" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ZFIN:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005024 ; owl:annotatedTarget "A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005024 ; owl:annotatedTarget "ZFA:0005733" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ZFIN:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005025 ; owl:annotatedTarget "A motor neuron that synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles and glands of the pulmonary, cardiovascular, and gastrointestinal systems." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0005025 ; owl:annotatedTarget "ZFA:0005732" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:CVS", "PMID:18356246", "PMID:20483998", "PMID:26798363", "https://orcid.org/0000-0003-1940-6740" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005026 ; owl:annotatedTarget "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation." . [] oboInOwl:hasDbXref "DOI:10.1016/j.stem.2014.04.010", "DOI:10.1093/jb/mvr001", "DOI:10.1242/dev.031369", "DOI:10.1242/dev.114215", "DOI:10.5966/sctm.2015-0051" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0005026 ; owl:annotatedTarget """Hepatoblasts are immature precursor cells that predominate during the early stages of liver development, specifically in the embryonic phase of life. They first arise from the endoderm, one of the three primary germ layers in the very early embryo, and then differentiate into two distinct mature liver cell types - the hepatocytes and cholangiocytes. During liver organogenesis hepatoblasts proliferate and migrate into the septum transversum to form the liver bud. Proliferation and differentiation of these cells are regulated by several soluble factors, such as hepatocyte growth factor, which is a mitogen of both hepatoblasts and mature hepatocytes. As they start to differentiate into hepatocytes and cholangiocytes, the cells begin to express hepatic markers like albumin and alpha-fetoprotein. Although hepatoblasts are specified embryonic liver cells that are bipotential for hepatocytes and cholangiocytes, a subset of liver cells (called oval cells) has been identified in adults that express stem cell markers, such as CD133 and cKIT, and has been suggested to have the same potential as hepatoblasts to differentiate into hepatocytes and cholangiocytes. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "hepatoblast on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0005026 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0005026" . [] oboInOwl:hasDbXref "GO_REF:0000034", "PMCID:PMC2737325" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007000 ; owl:annotatedTarget "Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins." . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007001 ; owl:annotatedTarget "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0007001 ; owl:annotatedTarget "scleroblast" . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007002 ; owl:annotatedTarget "Skeletogenic cell that has the potential to develop into a cementoblast." . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007003 ; owl:annotatedTarget "Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell." . [] oboInOwl:hasDbXref "UBERONREF:0000002" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007004 ; owl:annotatedTarget "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0007004 ; owl:annotatedTarget "ZFA:0007084" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "MESH:D002628" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000206 ; owl:annotatedTarget "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007005 ; owl:annotatedTarget "Cell that is part of the notochord." . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007006 ; owl:annotatedTarget "Mesodermal cell that is axially located and gives rise to the cells of the notochord." . [] oboInOwl:hasDbXref "CL:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007007 ; owl:annotatedTarget "Notochordal cell that is part of the outer epithelium of the notochord and surrounds the vacuolated notochord cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0007007 ; owl:annotatedTarget "ZFA:0005744" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "CL:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007008 ; owl:annotatedTarget "Notochordal cell that is inner portion of the notochord and becomes vacuolated as development proceeds." . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0007008 ; owl:annotatedTarget "chordablast" . [] oboInOwl:hasDbXref "PMID:14574572" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0007008 ; owl:annotatedTarget "chordoblast" . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007009 ; owl:annotatedTarget "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000206 ; owl:annotatedTarget "ZFA:0009124" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007010 ; owl:annotatedTarget "Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells." . [] oboInOwl:hasDbXref "DOI:10.1038/srep32884", "DOI:10.1096/fba.2020-00058", "DOI:10.1210/endo.141.9.7634", "DOI:10.12659/MSMBR.901142" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0007010 ; owl:annotatedTarget """Preosteoblast is a critical cell type involved in bone formation, crucial in a process known as ossification or osteogenesis. They are derived from mesenchymal stem cells and are an intermediate stage marking the transition from an osteoprogenitor cell to a fully differentiated osteoblast. The presence of preosteoblasts signifies the site of new bone deposition, highlighting their crucial role in skeletal development and in response to bone injury repairs. The primary function of preosteoblasts is to differentiate into osteoblasts, which are responsible for secreting osteoid (the unmineralized portion of bone matrix) and regulating the process of bone mineralization. Preosteoblasts are regulated by various growth factors and hormones, including bone morphogenic proteins (BMPs), fibroblast growth factors (FGFs), parathyroid hormone (PTH) and Vitamin D. However, the function of preosteoblasts is not limited to bone formation alone. In addition to osteogenesis, preosteoblasts significantly contribute to the maintenance of bone homeostasis through regulating the activity of osteoclasts - the cells responsible for bone resorption. This regulation is mediated through RANK/RANKL/OPG pathway signaling. Osteoprotegerin (OPG) released from the preosteoblasts acts as a decoy receptor for RANKL impairing osteoclast formation, hence preventing excessive bone resorption. This regulatory role indicates the dual functionality of preosteoblasts, which are indispensable for both the formation of new bone and the maintenance of existing bone tissue. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "preosteoblast on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0007010 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0007010" . [] oboInOwl:hasDbXref "CL:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007011 ; owl:annotatedTarget "Neuron that is part of the enteric nervous system." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0007011 ; owl:annotatedTarget "ZFA:0005775" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007012 ; owl:annotatedTarget "Odontoblast that non-terminally differentiated, located in the odontogenic papilla and dentine tissue, and transforms from a odontoblast cell." . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007013 ; owl:annotatedTarget "Odontoblast that is terminally differentiated and derived from an odontogenic papilla and associated with dentine." . [] oboInOwl:hasDbXref "ReO:mhb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007014 ; owl:annotatedTarget "OBSOLETE: A cultured cell that has been passaged at least one time in culture." . [] oboInOwl:hasDbXref "ReO:mhb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007015 ; owl:annotatedTarget "OBSOLETE: A cell line cell that is expected to be capable of replicating a limited number of times in culture before undergoing senescence. Mortal cell line cells cannot be propagated indefinitely (as immortal cell line cells can)." . [] oboInOwl:hasDbXref "PMID:8951054" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007016 ; owl:annotatedTarget "Muscle precursor cell that is adjacent to the notochord and part of the presomitic mesoderm." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0007016 ; owl:annotatedTarget "ZFA:0000003" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:1087183" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007017 ; owl:annotatedTarget "An epidermal cell with apical microvilli or a single apical projection have synaptic associations with nerve fibres in the epidermis." . [] oboInOwl:hasDbXref "PMCID:PMC3046089" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007018 ; owl:annotatedTarget "Ciliated cell of the embryonic epidermis and functions in embryonic movements." . [] oboInOwl:hasDbXref "PMID:3197630" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007020 ; owl:annotatedTarget "Characteristic early embryonic cell with a bottle or flask shape that is first to migrate inwards at the blastopore during gastrulation in amphibians." . [] oboInOwl:hasDbXref "ISBN-10:0412429403" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007021 ; owl:annotatedTarget "Secretory cell that produces a chemical mixture that triggers antipredator behavior. The substance is released only upon disruption of the epidermis. [Behavior of teleost fishes, second edition, edited by Pitcher, 1992]" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000026 ; owl:annotatedTarget "FBbt:00004878" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "https://github.com/obophenotype/cell-ontology/issues/583" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0007021 ; owl:annotatedTarget "club cell (zebrafish)" . [] oboInOwl:hasDbXref "ISBN-10:0412429403", "https://github.com/obophenotype/cell-ontology/issues/583" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0007021 ; owl:annotatedTarget "club cell" . [] oboInOwl:hasDbXref "PMID:18582455", "ZFA:0005239" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007022 ; owl:annotatedTarget "A specialized pore forming cell of the follicle, located adjacent to the animal pole of the oocyte. The micropylar cell makes the single micropyle (pore) through the chorion through which the sperm fertilizes the egg." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0007022 ; owl:annotatedTarget "ZFA:0005239" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "DOI:10.1007/BF00717048" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007023 ; owl:annotatedTarget "Epidermal cell rich in mitochondria. In amphibians, appears during metamorphosis." . [] oboInOwl:hasDbXref "GOC:DOS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008000 ; owl:annotatedTarget "Any muscle cell in which the fibers are not organised into sarcomeres." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008001 ; owl:annotatedTarget "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0323052908" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008002 ; owl:annotatedTarget "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." . [] oboInOwl:hasDbXref "PMID:22274696", "PMID:8720463" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008003 ; owl:annotatedTarget "A myotube that is part of some somatic muscle. Examples include arthropod somatic muscle cells." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008004 ; owl:annotatedTarget "A muscle cell that is part of some somatic muscle." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0008004 ; owl:annotatedTarget "FBbt:00005073" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:8720463", "doi:10.3908/wormatlas.1.7" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008005 ; owl:annotatedTarget "A somatic muscle cell that is obliquely striated and mononucleated. Examples include the somatic muscles of nematodes." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000207 ; owl:annotatedTarget "Any neuron that is capable of some detection of chemical stimulus involved in sensory perception of smell." . [] oboInOwl:hasDbXref "PMID:22274696" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008006 ; owl:annotatedTarget "A myoblast that detemines the properties (size, shape and attachment to the epidermis) of a `somatic muscle myotube` (CL:0008003) . It develops into a somatic muscle myotube via fusion with `fusion component myoblasts` (CL:0000621)." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008007 ; owl:annotatedTarget "A muscle cell that is part of some visceral muscle." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0008007 ; owl:annotatedTarget "FBbt:00005070" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000207 ; owl:annotatedTarget "ZFA:0009125" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008008 ; owl:annotatedTarget "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008009 ; owl:annotatedTarget "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods." . [] oboInOwl:hasDbXref "PMID:14699587" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008010 ; owl:annotatedTarget "A cranial motor neuron whose soma is located in the midbrain andor hindbrain and which innervates the skeletal muscles of the eye or tongue." . [] oboInOwl:hasDbXref "PMID:23303905" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008011 ; owl:annotatedTarget "A skeletal muscle satellite cell that divides by stem cell division. A proportion of this population undergoes symmetric stem cell division, producing two skeletal muscle satellite stem cells. The rest undergo asymmetric stem cell division - retaining their identity while budding off a daughter cell that differentiates into an adult skeletal muscle myoblast." . [] oboInOwl:hasDbXref "PMID:21849021", "PMID:23303905" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008012 ; owl:annotatedTarget "A skeletal muscle satellite cell that is mitotically quiescent. These cells are wedge shaped and have a large nuclear to cytoplasmic ratio with few organelles, a small nucleus and condensed interphase chromatin. Satellite cells typically remain in this state until activated following muscle damage." . [] oboInOwl:hasDbXref "PMID:14699587" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008013 ; owl:annotatedTarget "A visceromotor motor neuron whose soma is located in the hindbrain, and which synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles of the head." . [] a owl:Axiom ; rdfs:comment "More accurately - transformation_of ?" ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0008016 ; owl:annotatedTarget _:genid11008 . [] oboInOwl:hasDbXref "PMID:21849021", "PMID:23303905" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008016 ; owl:annotatedTarget "A skeletal muscle satellite cell that has become mitotically active - typically following muscle damage." . [] oboInOwl:hasDbXref "PMID:23303905" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008017 ; owl:annotatedTarget "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers." . [] oboInOwl:hasDbXref "PMID:23303905" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0008017 ; owl:annotatedTarget "myogenic precursor cell" . [] oboInOwl:hasDbXref "GOC:dos", "PMID:23303905" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008020 ; owl:annotatedTarget "A skeletal muscle satellite cell that undergoes symmetric division to produce two adult skeleltal muscle myoblasts." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000209 ; owl:annotatedTarget "A specialized cell involved in gustatory sensory perception." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008021 ; owl:annotatedTarget "Any peripheral nervous system neuron that has its soma located in some anterior lateral line ganglion." . [] oboInOwl:hasDbXref "PMID:18816864" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008022 ; owl:annotatedTarget "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000209 ; owl:annotatedTarget "ZFA:0009126" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008024 ; owl:annotatedTarget "An endocrine cell that is part of the pancreas." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008025 ; owl:annotatedTarget "A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0008025 ; owl:annotatedTarget "ZFA:0005873" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008026 ; owl:annotatedTarget "An epithelial cell that is part of the epithelium of a tracheal tube in an open tracheal system, such as that found in insects." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0008026 ; owl:annotatedTarget "FBbt:00005038" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008028 ; owl:annotatedTarget "Any neuron that is capable of part of some visual perception." . [] oboInOwl:hasDbXref "doi:10.1038/s41593-018-0205-2" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008032 ; owl:annotatedTarget "A GABAergic interneuron in human cortical layer 1 that has large rosehip-shaped axonal boutons and compact arborization." . [] oboInOwl:hasDbXref "doi:10.1038/s41593-018-0205-2" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0008032 ; owl:annotatedTarget "A rosehip cell has been shown to have an immunohistochemical profile GAD1+CCK+, CNR1–SST–CALB2–PVALB– that matches a single transcriptomically defined cell type whose specific molecular marker signature is not seen in mouse cortex." . [] oboInOwl:hasDbXref "PMID:30429548" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008033 ; owl:annotatedTarget "A pericyte of the decidual vasculature." . [] oboInOwl:hasDbXref "Wiki:Mural_cell&oldid=930603194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008034 ; owl:annotatedTarget "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0008034 ; owl:annotatedTarget "ZFA:0005944" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008035 ; owl:annotatedTarget "Any vascular associated smooth muscle cell that is part of some microcirculatory vessel." . [] oboInOwl:hasDbXref "PMID:31049600" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008036 ; owl:annotatedTarget "A trophoblast cell that is not part of a placental villous." . [] oboInOwl:hasDbXref "DOI:10.1007/s12522-011-0102-9", "DOI:10.1016/j.it.2017.01.009", "DOI:10.1016/j.preghy.2010.10.003", "DOI:10.1080/19336918.2015.1089376", "DOI:10.1080/19336918.2015.1120397" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0008036 ; owl:annotatedTarget """Extravillous trophoblasts (EVTs), a specialized subset of trophoblast cells, play crucial roles in establishing and sustaining pregnancy. Firstly, they anchor the fetus to the maternal tissue, providing structural stability. Secondly, they are instrumental in modifying the maternal spiral arteries to ensure an adequate supply of maternal blood to the placenta and the developing fetus. EVTs invade maternal decidua and myometrium and replace the endothelial lining of the spiral arteries, transforming these high-resistance, narrow vessels into low-resistance, wide vessels, favouring higher blood flow. Thirdly, these cells also play an immunological role, creating an environment conducive to the acceptance of the semi-allogeneic fetus, by expressing non-classical MHC molecules, thereby averting any potential maternal immune response towards fetal tissues. While EVTs are commonly associated with healthy pregnancies, abnormalities in their function or development have been connected to problematic pregnancies. Conditions like pre-eclampsia and fetal growth restriction (FGR) may arise if EVT cells do not effectively invade the maternal decidua or adequately remodel. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "PMID:31049600" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0008036 ; owl:annotatedTarget "EVT" . [] a owl:Axiom ; rdfs:label "extravillous trophoblast on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0008036 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0008036" . [] oboInOwl:hasDbXref "DOI:10.1093/acprof:oso/9780195159561.001.1", "WikipediaVersion:Gamma_motor_neuron&oldid=906640465" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008037 ; owl:annotatedTarget "A lower motor neuron that innervates only intrafusal muscle fibers. Unlike the alpha motor neurons, gamma motor neurons do not directly adjust the lengthening or shortening of muscles but function in adjusting the sensitivity of muscle spindles and in keeping muscle spindles taut, thereby allowing the continued firing of alpha neurons." . [] oboInOwl:hasDbXref "WikipediaVersioned:Gamma_motor_neuron&oldid=1037462173" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0008037 ; owl:annotatedTarget "fusimotor neuron" . [] oboInOwl:hasDbXref "DOI:10.1016/B978-0-12-801238-3.05364-2", "Wikipedia:Alpha_motor_neuron&oldid=957148643" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008038 ; owl:annotatedTarget "A large, multipolar lower motor neuron of the brainstem and spinal cord that innervates the extrafusal muscle fibers of skeletal muscle and are directly responsible for initiating their contraction. While their cell bodies are in the CNS (in the anterior gray horn of the spinal cord), they are part of the somatic nervous system - a branch of the PNS." . [] oboInOwl:hasDbXref "Wikipedia:Lower_motor_neuron&oldid=952547294" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008039 ; owl:annotatedTarget "The motor neurons of vertebrates that directly innervate skeletal muscles. They receive input from upper motor neurons." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008040 ; owl:annotatedTarget "An endothelial cell of the venule that is squamous shaped. This is in contrast to the cubodial shape of high endothelial venule cells." . [] oboInOwl:hasDbXref "MESH:D010786" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000210 ; owl:annotatedTarget "A cell specialized in detecting light stimuli that are involved in visual perception." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-7073-9172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008041 ; owl:annotatedTarget "A mesothelial cell that is part of the intestinal serosa." . [] oboInOwl:hasDbXref "PMID:23649873" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008042 ; owl:annotatedTarget "A tanycyte of the subfornical organ (SFO). These cells extend long and slender fibers extending from their cell bodies in the ependyma toward fenestrated capillaries associated with the SFO, where they form a dense network surrounding these capillaries." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000210 ; owl:annotatedTarget "FBbt:00004211" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:23649873" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0008042 ; owl:annotatedTarget "tanycyte-like cell of subfornical organ" . [] oboInOwl:hasDbXref "PMID:23649873" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008044 ; owl:annotatedTarget "A tanycyte of the area postrema (AP). These cells extend long and slender fibers extending from their cell bodies in the ependyma toward fenestrated capillaries associated with the AP, where they form a dense network surrounding these capillaries." . [] oboInOwl:hasDbXref "PMID:23649873" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0008044 ; owl:annotatedTarget "tanycyte-like cell of area postrema" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000210 ; owl:annotatedTarget "ZFA:0009127" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:23649873" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008045 ; owl:annotatedTarget "A tanycyte of the subcommisural organ (SCO). These cells extend long and slender fibers extending from their cell bodies in the ependyma toward fenestrated capillaries associated with the SCO, where they form a dense network surrounding these capillaries." . [] oboInOwl:hasDbXref "PMID:23649873" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0008045 ; owl:annotatedTarget "tanycyte-like cell of subcommissural organ" . [] oboInOwl:hasDbXref "DOI:10.1016/B978-0-443-10321-6.00004-7", "Wikipedia:Extrafusal_muscle_fiber&oldid=978415293" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008046 ; owl:annotatedTarget "A skeletal muscle fiber that is innervated by alpha motor neuron and generates tension by contracting, thereby allowing for skeletal movement. These fibers make up the large mass of skeletal muscle tissue and are attached to bones by tendons." . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000211 ; owl:annotatedTarget "A cell whose function is determined by the generation or the reception of an electric signal." . [] oboInOwl:hasDbXref "DOI:10.1016/B978-0-443-10321-6.00004-7", "Wikipedia:Intrafusal_muscle_fiber&oldid=937508784" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008047 ; owl:annotatedTarget "A skeletal muscle fiber that is part of a muscle spindle. These are specialized muscle fibers that serve as proprioceptors, detecting the amount and rate of change in length of a muscle. They are innervated by both sensory neurons and motor neurons (gamma and beta motorneurons, collectively referred to as fusimotor neurons)." . [] oboInOwl:hasDbXref "Wikipedia:Upper_motor_neuron&oldid=943248837" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008048 ; owl:annotatedTarget "A glutamatergic motor neuron with a soma in the brainstem or cerebral cortex. They do not synapse directly to muscles but rather to lower motor neurons, which do. They are the main controllers of voluntary movement." . [] oboInOwl:hasDbXref "DOI:10.1101/2020.03.31.016972", "Wikipedia:Betz_cell&oldid=977472330" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008049 ; owl:annotatedTarget "A giant pyramidal neuron with a soma in layer Vb of the primary motor cortex that sends its axons down the spinal cord via the corticospinal tract, either synapsing directly with alpha motor neurons, or targeting interneurons in the spinal cord. In humans, Betz cells are the largest known in the central nervous system." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000211 ; owl:annotatedTarget "ZFA:0009128" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:26578857", "PMID:35726097" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008053 ; owl:annotatedTarget "A capillary endothelial cell that is part of the circumventricular organs (CVOs), characterized by fenestrations that facilitate selective permeability to molecules, distinguishing it from the non-fenestrated endothelial cells of the blood-brain barrier. This cell is integral to the unique vascular structure of CVOs, which lack a traditional blood-brain barrier. It enables bidirectional exchange of polar molecules between blood and neural tissue, supporting neuroendocrine signaling, fluid balance, and immune responses. It is marked by the expression of PLVAP, a component of the fenestral diaphragm, in both rodents and humans." . [] oboInOwl:hasDbXref "DOI:10.1038/s41591-023-02327-2." ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008055 ; owl:annotatedTarget "A secretory epithelial cell of the respiratory tract epithelium. These cells have an endodermal origin." . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000212 ; owl:annotatedTarget "OBSOLETE. A cell that takes up and metabolizes substances." . [] oboInOwl:hasDbXref "PMID:18677503", "PMID:37124720" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008059 ; owl:annotatedTarget "A neuron that releases both gamma-aminobutyric acid and glycine as vesicular neurotransmitters. Examples include types of amacrine cell and types of cerebellar inhibitory neurons." . [] oboInOwl:hasDbXref "JB:jb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000213 ; owl:annotatedTarget "OBSOLETE. A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." . [] oboInOwl:hasDbXref "PMID:37124720", "PMID:38092916" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008060 ; owl:annotatedTarget "A neuron that releases both gamma-aminobutyric acid and glutamate as vesicular neurotransmitters." . [] oboInOwl:hasDbXref "PMID:29651049" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008061 ; owl:annotatedTarget "A neuron that releases both gamma-aminobutyric acid and acetylcholine as vesicular neurotransmitters. Examples include some types of striatal interneuron." . [] oboInOwl:hasDbXref "GOC:nv", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009000 ; owl:annotatedTarget "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000214 ; owl:annotatedTarget obo:CL_0002078 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000214 ; owl:annotatedTarget "ZFA:0009131" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009004 ; owl:annotatedTarget "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." . [] oboInOwl:hasDbXref "JB:jb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000215 ; owl:annotatedTarget "OBSOLETE. A cell whose primary function is to prevent the transport of stuff across compartments." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009006 ; owl:annotatedTarget "An enteroendocrine cell that is located in the small intestine." . [] oboInOwl:hasDbXref "DOI:10.1016/j.coph.2013.09.008", "DOI:10.1038/mi.2017.73", "DOI:10.1038/nature24489", "DOI:10.1111/j.1365-2613.2011.00767.x", "DOI:10.1146/annurev-physiol-021115-105439" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0009006 ; owl:annotatedTarget """The enteroendocrine cell of the small intestine is a specialized type of cell that forms part of the lining of the intestinal wall. These cells are interspersed among absorptive cells, mucus-secreting goblet cells, and other gut cell types, forming the crypt-villus axis, which is the functional unit of the small intestinal epithelium. Functionally, enteroendocrine cells play a pivotal role in the gut-endocrine system, which is responsible for the digestive process. These cells translate the luminal nutrient status into hormonal signals thereby acting as chemosensors. They contain secretory granules at their base which release hormones into the bloodstream following chemo-sensation. The hormones they secrete perform diverse functions including regulating gastric secretion, gut motility, insulin release, appetite control and other local and systemic effects. In addition to their endocrine functions, enteroendocrine cells also play a part in the modulation of the immune response in the gut. They can secrete cytokines and chemokines that have a role in directing the immune response to invading pathogens. Moreover, emerging research suggests that these cells play a role in maintaining the balance between gut resident bacteria, known as the gut microbiota, and the host. As such, a comprehensive understanding of the enteroendocrine cells of the small intestine underpins knowledge in nutrition, endocrinology, and various gastroenterological conditions. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "enteroendocrine cell of small intestine on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0009006 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0009006" . [] dc:license "http://creativecommons.org/licenses/by/4.0/" ; oboInOwl:hasDbXref "doi:10.1186/s13619-020-00061-5" ; a owl:Axiom ; rdfs:comment """Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer). ISC: Intestinal Stem Cell TA: Transit Amplifying Cells""" ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0009006 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009007 ; owl:annotatedTarget "A macrophage which is resident in the lamina propria of the small intestine." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009008 ; owl:annotatedTarget "A macrophage which is resident in the lamina propria of the large intestine." . [] oboInOwl:hasDbXref "PMID:31753849", "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009009 ; owl:annotatedTarget "A paneth cell that is located in the epithelium of the colon." . [] oboInOwl:hasDbXref "DOI:10.1002/ibd.20197", "DOI:10.1038/nature09637", "DOI:10.1038/nrmicro2546", "DOI:10.1093/ecco-jcc/jjac190.0884", "DOI:10.1136/gut.48.2.176" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0009009 ; owl:annotatedTarget """Paneth cells of the colon are specialized secretory epithelial cells that can be found in the large intestine, albeit in small numbers compared with the small intestine where Paneth cells are more abundant. Under disease conditions such as inflammatory bowel disease, Paneth cells increase in numbers in the colon. They reside in the crypts of Lieberkühn, which are glandular structures embedded within the mucosal layer of the small and large intestine. Paneth cells play a crucial role in maintaining intestinal homeostasis and acting as a frontline of defense in our bodies against ingested microbes. They achieve this through the secretion of antimicrobial peptides and proteins such as lysozyme and defensins, which can directly kill or inhibit the growth of various bacteria, fungi, and viruses. They degranulate these substances into the intestinal lumen, especially under conditions of pathogenic invasion or damage to the epithelial lining. Moreover, Paneth cells are essential for the maintenance of intestinal stem cells, which continually replace the epithelium of the intestine. They create a niche for these stem cells at the base of the crypts, secreting various signaling molecules and factors that are essential for the growth and differentiation of intestinal stem cells. In essence, the existence and function of Paneth cells are fundamental to the overall gut health and immune defense system, by providing both antimicrobial functions and a conducive environment for the renewal of the intestinal lining. The role of Paneth cells specifically in the colon is of interest in the context of inflammatory bowel disease, such as ulcerative colitis and Crohn’s disease: Their presence in the colon is thought to represent Paneth cell metaplasia and indicates a chronic inflammatory state. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "paneth cell of colon on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0009009 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0009009" . [] oboInOwl:hasDbXref "PMID:24813615", "PMID:28835754", "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009010 ; owl:annotatedTarget "Transit-amplifying cells (TACs) are an undifferentiated population in transition between stem cells and differentiated cells." . [] oboInOwl:hasDbXref "PMID:30827895" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0009010 ; owl:annotatedTarget "transit amplifying progenitor cell" . [] oboInOwl:hasDbXref "PMID:20801415", "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009011 ; owl:annotatedTarget "A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the colon. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells." . [] oboInOwl:hasDbXref "DOI:10.1016/j.cell.2014.02.057", "DOI:10.1053/j.gastro.2018.08.016", "DOI:10.1172/jci.insight.150894", "DOI:10.3389/fbioe.2023.1189225", "https://www.sciencedirect.com/topics/immunology-and-microbiology/intestinal-stem-cell" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0009011 ; owl:annotatedTarget """Transit amplifying cells (TACs) are an intermediate, undifferentiated population between stem cells and differentiated cells. They can be found in multiple regions such as the small intestine and the colon. TACs of the colon, are integral components of the colonic crypts and vital players in the maintenance of colonic tissue. These cells serve a critical function in the rapid and constant renewal of the epithelium lining the colon, with the whole epithelial surface renewed approximately every 5-7 days. They divide rapidly and progressively differentiate into mature columnar epithelium cells, including enterocytes, goblet cells, and enteroendocrine cells. The continued proliferation of transit amplifying cells is fundamental to maintain the balance in cell population while preventing tissue degeneration and maintaining a state of homeostasis. However, uncontrolled proliferation and compromised differentiation capacity can contribute to the development of colon cancers. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "transit amplifying cell of colon on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0009011 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0009011" . [] oboInOwl:hasDbXref "PMID:20801415", "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009012 ; owl:annotatedTarget "A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the small intestine. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells." . [] oboInOwl:hasDbXref "DOI:10.1007/s11894-010-0130-3", "DOI:10.1016/j.cell.2014.02.057", "DOI:10.1101/gad.1674008" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0009012 ; owl:annotatedTarget """Transit amplifying cells (TACs) represent an intermediate population between stem cells and fully differentiated cells, and can be found in multiple regions such as the colon and the small intestine. The small intestine's efficiency in absorbing nutrients, its protective barrier function, and its innate cellular renewal every few days is largely dependent on the role played by these TACs. TACs of the small intestine are primarily present in the crypt-villus structure of the intestine, more specifically in the crypt region. They originate from Lgr5+ intestinal stem cells that reside at the base of the crypts. Following their derivation from stem cells, TACs undergo up to six rounds of rapid division over a 48-72 hour period, effectively amplifying the cell population, hence their name. During this process, they gradually migrate upward along the walls of the crypt from where they differentiate into diverse mature cell types such as enterocytes, goblet cells, and Paneth cells. TACs serve as an important element in the homeostasis and regeneration of the intestinal epithelium, amplifying the pool of cells available for differentiation. They also minimize genetic errors during DNA replication by serving as a 'buffer zone' between the long-lived stem cells and the terminal differentiated cells of the gut lining, thus reducing the potential for propagation of mutation-causing defects. Lastly, TACs play an essential part in gastrointestinal tissue repair following injury or inflammation. Their rapid proliferation and subsequent differentiation abilities often help expedite the wound healing process in the intestinal epithelium. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "transit amplifying cell of small intestine on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0009012 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0009012" . [] dc:license "http://creativecommons.org/licenses/by/4.0/" ; a owl:Axiom ; rdfs:comment """Figure depicts a cross section of intestinal villi in the small intestine , including the crypts of Lieberkhun (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer). ISC: Intestinal Stem Cell TA: Transit Amplifying Cells""" ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0009012 ; owl:annotatedTarget . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000216 ; owl:annotatedTarget obo:CL_0000630 . [] oboInOwl:hasDbXref "PMID:31350390", "https://orcid.org/0000-0002-3163-0115" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009013 ; owl:annotatedTarget "A progenitor cell with hepatic and biliary lineage potential, identified in mouse and human, and anatomically restricted to the ductal plate of fetal liver." . [] oboInOwl:hasDbXref "PMID:23525039", "PMID:9252325", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009014 ; owl:annotatedTarget "A lymphocyte that is part of a Peyer's patch. These cells have a major role in driving the immune response to antigens sampled from the intestinal lumen, and in regulating the formation of follicle-associated epithelium and M cells in Peyer's patches by converting intestitial enterocytes into M cells." . [] oboInOwl:hasDbXref "MESH:D012708" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000216 ; owl:annotatedTarget "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." . [] oboInOwl:hasDbXref "PMID:24437401", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009015 ; owl:annotatedTarget "A follicular dendritic cell located in the Peyer's patch. These cells from a meshwork in which Peyer's patch B cells reside." . [] oboInOwl:hasDbXref "PMID:20683682", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009016 ; owl:annotatedTarget "An intestinal stem cell that is located in the large intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the large intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM294.HJJZ.279" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0009016 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/large-intestine-crypt-lieberkuhn/v1.2/assets/2d-ftu-large-intestine-crypt-lieberkuhn.png" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000216 ; owl:annotatedTarget "ZFA:0009133" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:20683682", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009017 ; owl:annotatedTarget "An intestinal stem cell that is located in the small intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the small intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells." . [] oboInOwl:hasDbXref "DOI:10.1016/j.celrep.2020.107952", "DOI:10.1038/s41575-018-0081-y", "DOI:10.1073/pnas.1607327113" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0009017 ; owl:annotatedTarget """Intestinal crypt stem cells of the small intestine are a type of adult stem cell intimately involved in the continuous replenishment of the intestinal epithelium, the innermost layer of the intestine responsible for nutrient absorption. These cells, located within the crypts of Lieberkühn, are the origin of various cell lineages that make up the functional units of the small intestine. They possess self-renewal ability, an essential feature of stem cells, which allows them to maintain a steady population in the small intestine. One of the critical roles of intestinal crypt stem cells is to drive the continual renewal process taking place in the small intestine every 3-5 days. By proliferating intensively, these cells produce transient amplifying (TA) cells that are characterized by quick division and progressive differentiation. These cells eventually differentiate into specialized cell types, encompassing absorptive enterocytes, mucin-secreting goblet cells, hormone-secreting enteroendocrine cells, and Paneth cells, all of which have essential roles in digestion and nutrient absorption in the small intestine. Intestinal crypt stem cells of the small intestine are also play a significant part in injury recovery. Under regular conditions, these cells primarily exist in an active state, facilitating the constant renovation of the gut lining. However, upon injury or loss of regular intestinal crypt stem cells reserve intestinal stem cells, a slow-cycling and radio-resistant population, can be stimulated to take over the duties of active crypt stem cells. Such plasticity provides a powerful regenerative mechanism that ensures the intestinal epithelium's function and structural integrity amidst diverse conditions. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "intestinal crypt stem cell of small intestine on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0009017 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0009017" . [] dc:license "http://creativecommons.org/licenses/by/4.0/" ; oboInOwl:hasDbXref "doi:10.1186/s13619-020-00061-5" ; a owl:Axiom ; rdfs:comment """Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer). ISC: Intestinal Stem Cell TA: Transit Amplifying Cells""" ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0009017 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009018 ; owl:annotatedTarget "A lymphocyte that resides in the lamina propria of the large intestine." . [] oboInOwl:hasDbXref "GOC:cvs", "GOC:tfm", "MESH:D012583" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000218 ; owl:annotatedTarget "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." . [] oboInOwl:hasDbXref "PMID:29449449", "https://orcid.org/0000-0002-3163-0115" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009019 ; owl:annotatedTarget "A kidney cortical cell that is part of the nephrogenic zone." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009020 ; owl:annotatedTarget "An intestinal tuft cell that is a part of a vermiform appendix." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000218 ; owl:annotatedTarget "ZFA:0009135" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009021 ; owl:annotatedTarget "A stromal cell found in the lamina propria of the large intestine." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009022 ; owl:annotatedTarget "A stromal cell found in the lamina propria of the small intestine." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009023 ; owl:annotatedTarget "A T cell which resides in the Peyer's patch of the small intestine." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009024 ; owl:annotatedTarget "A mesothelial cell that is part of the small intestine." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876", "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009025 ; owl:annotatedTarget "A mesothelial cell that is part of the colon." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009026 ; owl:annotatedTarget "An enterocyte that is a part of a vermiform appendix." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009027 ; owl:annotatedTarget "A transit amplifying cell that is part of a crypt of Lieberkuhn of large intestine." . [] oboInOwl:hasDbXref "PMID:20683682", "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009028 ; owl:annotatedTarget "An intestinal crypt stem cell that is located in the vermiform appendix. These stem cells reside at the bottom of crypts in the appendix and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009029 ; owl:annotatedTarget "A mesothelial cell that is located in a vermiform appendix." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009030 ; owl:annotatedTarget "An intestinal enteroendocrine cell that is located in a vermiform appendix." . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000219 ; owl:annotatedTarget "A cell that moves by its own activities." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009031 ; owl:annotatedTarget "A T cell that is located in a vermiform appendix." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009032 ; owl:annotatedTarget "A B cell that is located in a vermiform appendix." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000219 ; owl:annotatedTarget "ZFA:0009136" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009033 ; owl:annotatedTarget "A plasma cell that is located in a vermiform appendix." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009034 ; owl:annotatedTarget "A dendritic cell that is located in a vermiform appendix." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009035 ; owl:annotatedTarget "A stromal cell found in the lamina propria of the vermiform appendix." . [] oboInOwl:hasDbXref "MESH:D004475" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000221 ; owl:annotatedTarget "A cell of the outer of the three germ layers of the embryo." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009036 ; owl:annotatedTarget "A macrophage located in the vermiform appendix." . [] oboInOwl:hasDbXref "PMID:8011279", "http://orcid.org/0000-0003-4183-8865/", "https://www.arppress.org/v/vspfiles/assets/images/Chapter1T25LymphNodes.pdf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009037 ; owl:annotatedTarget "A B lymphocyte that resides in the mantle zone of the lymph node germinal center. These are generally IgM and IgD positive activated B cells that form a 'corona' around the germinal center and are part of the establishment of a secondary lymphatic follicule." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000221 ; owl:annotatedTarget "ZFA:0009137" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009038 ; owl:annotatedTarget "A macrophage that is located in the colon." . [] oboInOwl:hasDbXref "DOI:10.1016/j.immuni.2022.08.005", "DOI:10.1016/j.jcmgh.2021.08.021", "DOI:10.1038/s41575-019-0172-4", "DOI:10.1038/s41575-023-00769-0" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0009038 ; owl:annotatedTarget """Colon macrophages are a heterogeneous population of macrophages in the gastrointestinal tract. Intestinal macrophages represent the largest group of macrophages in the body and play a key role as sentinels for pathogen recognition and elimination. Because the gastrointestinal tract is continually exposed to a high antigenic load derived from microbes and food intake, macrophages in the intestines are crucial not only for the gut’s immune defense but also for maintaining gastrointestinal homeostasis, avoiding chronic inflammation despite constantly facing foreign antigens. The phenotypic profiles and cytokine production of intestinal macrophages therefore differ from conventional macrophages elsewhere in the body. Colon macrophages orchestrate a wide variety of immune responses. They interact with the colon’s microflora thanks to their location in the mucosal layer, thus playing an important role in shaping gut immunity. By presenting antigens, they help to activate and steer an appropriate immune response either by triggering inflammation against harmful pathogens or by supporting tolerance for beneficial microbes. Therefore, disturbances in the colon macrophage population is thought to contribute to colon-related diseases such as inflammatory bowel disease and colon cancer. These immune cells are versatile and multifunctional, not just limited to defensive actions. Colon macrophages interact with the enteric nervous system to regulate gut secretion and motility. They also play a crucial role in maintaining colon tissue health and integrity by contributing to tissue repair processes. This occurs either through phagocytosis of dead cells and remnants, or indirectly through the release of growth factor molecules, which stimulate cellular proliferation and differentiation necessary for tissue regeneration. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "colon macrophage on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0009038 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0009038" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009039 ; owl:annotatedTarget "A goblet cell that is located in the colon." . [] oboInOwl:hasDbXref "DOI:10.1038/mi.2015.32", "DOI:10.1038/mi.2016.132", "DOI:10.1038/nrgastro.2013.35", "DOI:10.1038/s41385-018-0039-y", "DOI:10.1073/pnas.1006451107" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0009039 ; owl:annotatedTarget """Colon goblet cells are a subset of intestinal goblet cells that are localized in the epithelial lining of the colon. They are specialized secretory epithelial cells that are recognized by their characteristic ‘goblet’ or flask-like shape and typically have a distinctive appearance due to the accumulation of secretory vesicles in their cytoplasm. The primary function of goblet cells is the secretion of mucus, which is an essential substance for the protection and successful functioning of the intestinal tract. In the colon, goblet cells continuously renew the inner mucus layer, which is attached and impervious to bacteria (the outer layer of the colon is unattached and is the habitat of commensal bacteria) The mucus secreted by goblet cells is rich in glycoproteins known as mucins, especially MUC2, forming a complex web of molecules that comprises the foundational structure of the mucus layer. It traps and eliminates harmful bacteria, while selectively allowing beneficial microbiota to access the epithelial surface and aid in digestion and nutrient absorption. The mucus layer not only provides a provides a protective barrier against pathogen invasion, as well as mechanical damage, and the erosive effects of digestive enzymes, it also acts as a lubricant to facilitate the passage of food material. Colon goblet cells are also involved in regulating the local immune response within the gut, maintaining the delicate balance between necessary immune reactions to harmful pathogens and tolerance to beneficial microbiota and dietary substances. Goblet cells can modulate immune responses by presenting antigens to dendritic cells, as well as through the production of immunomodulatory molecules that can alter the behavior of immune cells. When the inner mucus layer of the colon is defective, it might be a pathophysiological mechanism for colitis and infectious diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "colon goblet cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0009039 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0009039" . [] oboInOwl:hasDbXref "MESH:D008648" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000222 ; owl:annotatedTarget "A cell of the middle germ layer of the embryo." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009040 ; owl:annotatedTarget "A stromal cell found in the lamina propria of the colon." . [] oboInOwl:hasDbXref "PMID:33079783", "PMID:35271673", "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009041 ; owl:annotatedTarget "A tuft cell that is part of the colonic epithelium, primarily adapted for microbial sensing in the dense colonic microbiota. Unlike its small intestinal counterpart, it does not participate in parasite-driven tuft cell–ILC2 circuits. Instead, it detects bacterial metabolites via taste-signaling pathways (Strine and Craig, 2022). The colonic tuft cell plays a key role in epithelial repair, modulates inflammatory responses through IL-25 secretion, and contributes to intestinal homeostasis by balancing microbiome interactions (Sebastian et al., 2021)." . [] oboInOwl:hasDbXref "DOI:10.1152/ajpgi.00073.2017", "DOI:10.1371/journal.ppat.1010318", "DOI:10.3389/fimmu.2022.822867" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0009041 ; owl:annotatedTarget """Tuft cells, also often referred to as brush cells or caveolated cells, are highly specialized sensory cells found in the colon, among other organs. They were named for their unique appearance under an electron microscope, which presents a distinctive ‘tuft-like’ morphology. They are characterized by apical microvilli, arranged in an irregular tuft that confers a dome-like shape. These cells comprise only a small fraction of the cells in the epithelial layer of the colon, making them among the least populous cell types in this region. Tuft cells in the colon primarily function as chemosensory cells that can sense and respond to environmental changes. These cells can detect and respond to microbial metabolites, helping initiate immune responses against potential threats. Recent studies have revealed that tuft cells play a role in responding to intestinal parasitic infections. When a gastrointestinal parasite infects the colon, tuft cells are activated and release the cytokine IL-25. This action increases the production of tuft cells and triggers essential Th2 immune responses to expel the parasites. Also, the removal of tuft cells has been linked to increased susceptibility to these infections. However, overactivity of tuft cells has been associated with inflammatory bowel disease, highlighting the need for a delicate balance of tuft cell function to maintain colon homeostasis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "tuft cell of colon on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0009041 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0009041" . [] oboInOwl:hasDbXref "DOI:10.1016/j.ceb.2019.07.012", "DOI:10.5535/arm.2016.40.1.162", "https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/mesoderm" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000222 ; owl:annotatedTarget """Mesodermal cells are pluripotent and the most abundant in the human body. They contribute to the development of several structures such as the skeletal muscles, bones, heart and blood vessels, kidneys, gonads, connective tissues, and certain layers of the skin. Hence, the mesoderm is often regarded as an active and diverse layer due to its role in forming many bodily structures. In embryonic development, these cells are instrumental, contributing to the body's structures through a carefully coordinated sequence of morphogenetic movements. This process forms the complex multicellular architecture of tissues and organs from a simple ball of cells. Without the function of mesodermal cells, the body's integral structures and systems would cease to form correctly, leading to developmental disorders such as axial mesodermal dysplasia complex (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009042 ; owl:annotatedTarget "An enteroendocrine cell that is located in the colon." . [] oboInOwl:hasDbXref "PMID:10841502", "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009043 ; owl:annotatedTarget "An intestinal crypt stem cell that is located in the crypt of Lieberkuhn of colon." . [] oboInOwl:hasDbXref "DOI:10.1016/j.cell.2013.07.004", "DOI:10.1038/s41575-018-0081-y", "DOI:10.1073/pnas.1607327113", "DOI:10.1111/j.1365-2184.2009.00642.x", "DOI:10.1186/s12943-019-0962-x" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0009043 ; owl:annotatedTarget """Intestinal crypt stem cells of the colon, also known as colon crypt base columnar (CBC) cells, are highly specialized cells primarily responsible for the constant self-renewal of the colonic epithelium. These cells are found in the crypts of Lieberkühn - deeply invaginated sections of the colon's mucosal layer. The prime function of intestinal crypt stem cells of the colon is to serve as the source of constant cell regeneration in the colon. Every few days, these stem cells divide and differentiate into the various other types of intestinal cells, such as enterocytes, goblet cells, and enteroendocrine cells. A constant renewal cycle is necessary due to the harsh environment of the colon where cells continuously encounter abrasive food matter and potential pathogens, leading to a high turnover rate. When the colon's mucosal layer suffers damage, a rapid response is triggered whereby colon crypt stem cells divide faster and are directed to injured sites to repair the epithelial layer. Dysregulation of these cells' function or proliferation can contribute to disorders such as colorectal cancer. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000222 ; owl:annotatedTarget "ZFA:0009138" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "intestinal crypt stem cell of colon on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0009043 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0009043" . [] oboInOwl:hasDbXref "PMID:26551552", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009044 ; owl:annotatedTarget "A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response." . [] dc:license "http://creativecommons.org/licenses/by/4.0/" ; oboInOwl:hasDbXref "doi:10.1186/s13619-020-00061-5" ; a owl:Axiom ; rdfs:comment """Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer). ISC: Intestinal Stem Cell TA: Transit Amplifying Cells""" ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0009044 ; owl:annotatedTarget . [] a owl:Axiom ; rdfs:label "mesodermal cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000222 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000222" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009045 ; owl:annotatedTarget "A B cell found in the lymph node medullary sinus." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009046 ; owl:annotatedTarget "A T cell found in the lymph node medullary sinus." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009047 ; owl:annotatedTarget "A macrophage found in the medullary sinus of the lymph node." . [] oboInOwl:hasDbXref "MESH:D004707" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000223 ; owl:annotatedTarget "A cell of the inner of the three germ layers of the embryo." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009048 ; owl:annotatedTarget "A macrophage that is located in the anorectum." . [] oboInOwl:hasDbXref "PMID:27881983", "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009049 ; owl:annotatedTarget "A layer of smooth muscle cells that forms the outer layer of the high endothelial venule of lymph node and pumps to allow flow of lymph fluid carrying lymphocytes." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000223 ; owl:annotatedTarget "ZFA:0009139" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009050 ; owl:annotatedTarget "A B cell that is located in the anorectum." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009051 ; owl:annotatedTarget "A T cell that is located in the anorectum." . [] oboInOwl:hasDbXref "FB:ma", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000224 ; owl:annotatedTarget "OBSOLETE: A classification of cells by the number of their nuclei." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009052 ; owl:annotatedTarget "A smooth muscle cell that is located in the anorectum." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009053 ; owl:annotatedTarget "A stromal cell found in the lamina propria of the anorectum." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009054 ; owl:annotatedTarget "A microfold cell (M cell) that is part of the anorectum." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009055 ; owl:annotatedTarget "A paneth cell that is located in the anorectum." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000027 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009056 ; owl:annotatedTarget "A transit amplifying cell that is located in the anorectum." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009057 ; owl:annotatedTarget "A goblet cell that is located in the anorectum." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009058 ; owl:annotatedTarget "An enterocyte that is located in the anorectum." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009059 ; owl:annotatedTarget "A plasma cell that is located in the medullary sinus of the lymph node." . [] oboInOwl:hasDbXref "WikipediaVersioned:Marginal_zone_B-cell&oldid=1032071222", "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009060 ; owl:annotatedTarget "A mature B cell located in the marginal zone of the lymph node." . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000225 ; owl:annotatedTarget "A cell that lacks a nucleus." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009061 ; owl:annotatedTarget "An intestinal crypt stem cell that is located in the anorectum." . [] oboInOwl:hasDbXref "PMID:21739669", "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009062 ; owl:annotatedTarget "A specialized type of CD4 positive T cell, the follicular helper T cell (TFH cell), that upregulates CXCR5 expression to enable its follicular localization. These specialised T cells reside in the germinal center of the lymph node." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009063 ; owl:annotatedTarget "An enteroendocrine cell that is located in the anorectum." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009064 ; owl:annotatedTarget "A T cell located in the lymph node paracortex, where macrophages and dendritic cells present antigenic peptides to these naïve T cells, stimulating them to become activated helper T cells or cytotoxic T lymphocytes." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009065 ; owl:annotatedTarget "An intestinal tuft cell that is located in the anorectum." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009066 ; owl:annotatedTarget "A stratified squamous epithelial cell that is part of the anal canal." . [] oboInOwl:hasDbXref "PMID:17901585", "http://orcid.org/0000-0002-7073-9172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009067 ; owl:annotatedTarget "An enterocyte found in the small intestine of newborn mammals and characterized by the presence of an apical canalicular system (ACS) leading to production of large vacuoles, important for colostral macromolecule uptake. After birth, the vacuolated fetal-type enterocytes are replaced with enterocytes lacking an ACS." . [] oboInOwl:hasDbXref "PMID:33290721", "https://orcid.org/0000-0001-9610-7627" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0009067 ; owl:annotatedTarget "early enterocyte" . [] oboInOwl:hasDbXref "PMID:33290721", "https://orcid.org/0000-0001-9610-7627" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0009067 ; owl:annotatedTarget "immature enterocyte" . [] oboInOwl:hasDbXref "PMID:32079746" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009068 ; owl:annotatedTarget "An unconventional T lymphocyte population within the thymic medulla that is potentially a thymic resident population." . [] oboInOwl:hasDbXref "PMID:32079746" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009069 ; owl:annotatedTarget "An unconventional T lymphocyte population within the thymic medulla that expresses both alpha/beta and gamma/delta T cell signatures." . [] oboInOwl:hasDbXref "PMID:32079746", "PMID:33597545" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009070 ; owl:annotatedTarget "A thymic epithelial cell located at the corticomedullary junction." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM322.LZLG.752" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0009070 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" . [] oboInOwl:hasDbXref "PMID:24084687", "PMID:32079746", "PMID:33597545" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009071 ; owl:annotatedTarget "A thymic medullary epithelial cell considered to be a pre-AIRE mTEC population." . [] oboInOwl:hasDbXref "PMID:17067941", "PMID:24084687", "PMID:32079746", "PMID:33597545" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009072 ; owl:annotatedTarget "A thymic medullary epithelial cell that expresses AIRE or other canonical markers of mature mTECs like Fezf2." . [] oboInOwl:hasDbXref "PMID:16121185", "PMID:17067941", "PMID:20861360", "PMID:24084687", "PMID:32079746", "PMID:33597545", "PMID:33868260" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009073 ; owl:annotatedTarget "A thymic medullary epithelial cell considered to be a post-AIRE cell. This group of AIRE-mTECs is heterogeneous and also includes mTECs within Hassall's Corpuscles." . [] oboInOwl:hasDbXref "PMID:33868260" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0009073 ; owl:annotatedTarget "corneocyte-like mTECs" . [] oboInOwl:hasDbXref "PMID:33868260" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0009073 ; owl:annotatedTarget "corneocyte-like medullary thymic epithelial cell" . [] oboInOwl:hasDbXref "PMID:33868260" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0009073 ; owl:annotatedTarget "post-Aire cell" . [] oboInOwl:hasDbXref "PMID:33868260" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0009073 ; owl:annotatedTarget "mTEC III" . [] oboInOwl:hasDbXref "PMID:30022164", "PMID:32079746" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009074 ; owl:annotatedTarget "A thymic medullary epithelial cell that expresses typical tuft cell markers instead of classical mTEC or cTEC markers. This population has a bulbous-like structure." . [] oboInOwl:hasDbXref "PMID:32079746", "PMID:33597545" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009075 ; owl:annotatedTarget "A thymic medullary epithelial cell that expresses muscle-specific biomarkers." . [] oboInOwl:hasDbXref "PMID:32079746", "PMID:33597545" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009076 ; owl:annotatedTarget "A thymic medullary epithelial cell that expresses neuroendocrine biomarkers." . [] oboInOwl:hasDbXref "FB:ma", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000226 ; owl:annotatedTarget "A cell with a single nucleus." . [] oboInOwl:hasDbXref "PMID:6209968" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009077 ; owl:annotatedTarget "A thymic epithelial cell located within the subcapsular region of the thymus." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM322.LZLG.752" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0009077 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" . [] oboInOwl:hasDbXref "PMID:32079746" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009078 ; owl:annotatedTarget "A fibroblast located in the thymic capsule." . [] oboInOwl:hasDbXref "PMID:32079746" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009079 ; owl:annotatedTarget "A fibroblast located between thymic lobules." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000027 ; owl:annotatedTarget "A smooth muscle cell derived from the neural crest." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876", "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009080 ; owl:annotatedTarget "A tuft cell located in the small intestine." . [] terms:license "http://creativecommons.org/licenses/by/4.0/" ; oboInOwl:hasDbXref "doi:10.1186/s13619-020-00061-5" ; a owl:Axiom ; rdfs:comment """Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer). ISC: Intestinal Stem Cell TA: Transit Amplifying Cells""" ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0009080 ; owl:annotatedTarget . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM974.XQDB.889" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0009080 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/small-intestine-villus/v1.0/assets/2d-ftu-small-intestine-villus.png" . [] oboInOwl:hasDbXref "PMID:32304633" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009081 ; owl:annotatedTarget "The human equivalent of a DN2 thymocyte; typically contains two phases, in the latter of which these thymocytes begin the process of beta selection." . [] oboInOwl:hasDbXref "PMID:32304633" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009082 ; owl:annotatedTarget "The human equivalent of a DN3 thymocyte; these thymocytes finish the process of beta selection." . [] oboInOwl:hasDbXref "PMID:32304633" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009083 ; owl:annotatedTarget "The human equivalent of a DN4 thymocyte." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009084 ; owl:annotatedTarget "An epithelial cell that is part of an endometrium glandular epithelium." . [] oboInOwl:hasDbXref "WikipediaVersioned:Endothelial_progenitor_cell&oldid=1069930016#Colony_forming_unit_–_Hill" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009085 ; owl:annotatedTarget "An adult endothelial progenitor cell characterised in vivo by homing to ischemic sites and paracrine support of angiogenesis. They may form discrete colonies." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009086 ; owl:annotatedTarget "An endothelial cell that is part of a respiratory system lymphatic vessel." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009087 ; owl:annotatedTarget "An extravillous trophoblast that is polynuclear." . [] oboInOwl:hasDbXref "WikipediaVersioned:Endothelial_progenitor_cell&oldid=1069930016#Circulating_angiogenic_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009088 ; owl:annotatedTarget "An adult endothelial progenitor cell characterised in vivo by homing to ischemic sites and paracrine support of angiogenesis. These cells do not form colonies." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009089 ; owl:annotatedTarget "A pericyte cell that is part of a lung." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0009089 ; owl:annotatedTarget "The marker set HIGD1B, KCNK3 can identify the Human cell type lung pericyte in the lung with a confidence of 0.84 (NS-Forest FBeta value)." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM558.BZLS.992" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0009089 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" . [] oboInOwl:hasDbXref "PMID:33419165", "WikipediaVersioned:Endothelial_colony_forming_cell&oldid=1068242094", "http://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009090 ; owl:annotatedTarget "An adult endothelial progenitor cell that is resident of adult vasculature and capable of differentiating to regenerate endothelial cell populations. Endothelial colony forming cells are characterised in vivo by clonal proliferative status, de novo vessel formation, homing to ischemic sites and paracrine support of angiogenesis. These cells are phenotypically similar to endothelial cells." . [] oboInOwl:hasDbXref "PMID:21181888", "http://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009091 ; owl:annotatedTarget "A stem cell found in the interstitial compartment of the neonatal testis; it is capable of self-renewal as well as differentiation into steroidogenic cells (adult Leydig cells). Intermediate stages of development include progenitor Leydig cells and immature Leydig cells." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009092 ; owl:annotatedTarget "An endothelial cell that is part of a placenta." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009093 ; owl:annotatedTarget "A smooth muscle cell that is part of a placenta." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000227 ; owl:annotatedTarget "Any cell that has characteristic some binucleate." . [] oboInOwl:hasDbXref "PMID:30348985", "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009094 ; owl:annotatedTarget "An endothelial cell that is part of a hepatic portal vein." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009095 ; owl:annotatedTarget "An endothelial cell that is part of a uterus." . [] oboInOwl:hasDbXref "DOI:10.1002/cphy.c190015", "DOI:10.1111/aji.12128", "DOI:10.1172/jci.insight.163422", "DOI:10.1530/REP-09-0147", "DOI:10.2174/1570161111311050010" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0009095 ; owl:annotatedTarget """The endothelial cell of the uterus is a specialized type of endothelial cell found in the inner lining of blood vessels, specifically those in the uterus. These cells play critical roles in maintaining uterine health, fertilization, and pregnancy processes. They form the interior surface of blood vessels, creating a barrier between the vessel lumen and surrounding tissue. This fluid environment, maintained by these endothelial cells, provides a platform for the material exchange between blood and tissues, thereby modulating blood coagulation, immune responses, and controlling vasodilation and vasoconstriction. Functionally, the endothelial cells of the uterus are paramount in regulating the uterine blood flow, an important determinant of successful conception and pregnancy outcomes. They support the vascular changes during the reproductive cycle, particularly the spiral arteriolar development and function, essential in endometrial thickening, maturation, and eventual shedding during menstruation periods. The cells also contribute to angiogenesis, a process crucial during implantation and placenta development, whereby new blood vessels form from pre-existing vessels to supply the growing fetus with oxygen and nutrients. Uterine endothelial cells are also implicated in mediating immune responses within the uterus. Changes in these cells can influence various conditions such as reproductive disorders and complications including heavy menstrual bleeding, endometrial hyperplasia, fertility problems, and cancer. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "endothelial cell of uterus on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0009095 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0009095" . [] oboInOwl:hasDbXref "PMID:11694559", "http://orcid.org/0000-0003-2034-601X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009096 ; owl:annotatedTarget "Any cell that is part of the esophageal non-keratinized stratified squamous epithelium. In humans, the esophagus, which requires flexibility to accommodate swallowing of a bolus, is covered with a non-keratinized epithelium." . [] oboInOwl:hasDbXref "PMID:32094117", "PMID:7196501", "http://orcid.org/0000-0003-2034-601X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009097 ; owl:annotatedTarget "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development." . [] oboInOwl:hasDbXref "PMID:26180627", "PMID:7196501", "http://orcid.org/0000-0003-2034-601X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009098 ; owl:annotatedTarget "A skeletal muscle fiber found at the fetal and neonatal stages. In mammalian fetuses and neonates, skeletal muscle expresses myosin heavy chain-neonatal (MyHC-neo, encoded by the MYH8 gene). This expression disappears shortly after birth and is replaced by expression of adult heavy chain myosins." . [] oboInOwl:hasDbXref "PMID:20081841", "PMID:22045730", "PMID:24605102" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009099 ; owl:annotatedTarget "A progenitor cell that is a tissue-resident mesenchymal cell, important for skeletal muscle regeneration, and able to differentiate into both adipocytes or fibroblasts." . [] oboInOwl:hasDbXref "PMID:20209607", "PMID:24814904", "https://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009100 ; owl:annotatedTarget "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM889.CJPK.447" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0009100 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" . [] oboInOwl:hasDbXref "PMID:35440118" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0009101 ; owl:annotatedTarget "FRC" . [] oboInOwl:hasDbXref "PMID:21435450", "PMID:22566825", "PMID:25998961", "PMID:28262465", "PMID:29752062", "PMID:34256989", "https://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009102 ; owl:annotatedTarget "A specialized, fibroblastic reticular cell of mesenchymal origin found in lymph nodes. In human, it expresses several markers common to myofibroblasts (desmin, vimentin, CD73, CD90, α-smooth muscle actin (αSMA)), and can be differentiated from endothelial cells by its lack of CD31 expression. These cells are critical for the overall organization and function of the lymph node. Lymph node fibroblastic reticular cells (FRCs) can be further classified based on their location, function, and unique marker expression." . [] oboInOwl:hasDbXref "PMID:21435450", "PMID:22566825", "PMID:25998961", "PMID:28262465", "PMID:29752062", "PMID:34256989", "https://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009103 ; owl:annotatedTarget "A fibroblastic reticular cell found in the lymph node subcapsular sinus." . [] oboInOwl:hasDbXref "PMID:21435450", "PMID:22566825", "PMID:25998961", "PMID:28262465", "PMID:29752062", "PMID:34256989", "https://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009104 ; owl:annotatedTarget "A fibroblastic reticular cell found in the lymph node germinal center dark zone (B cell zone)." . [] oboInOwl:hasDbXref "PMID:21435450", "PMID:22566825", "PMID:25998961", "PMID:28262465", "PMID:29752062", "PMID:34256989", "https://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009105 ; owl:annotatedTarget "A fibroblastic reticular cell found in the lymph node T cell domain." . [] oboInOwl:hasDbXref "PMID:34256989" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0009105 ; owl:annotatedTarget "interfollicular reticular cell" . [] oboInOwl:hasDbXref "PMID:21435450", "PMID:22566825", "PMID:25998961", "PMID:28262465", "PMID:29752062", "PMID:33981032", "PMID:34256989", "https://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009106 ; owl:annotatedTarget "A specialized fibroblast found in the medulla of lymph node." . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0009106 ; owl:annotatedTarget "MedRC" . [] oboInOwl:hasDbXref "FB:ma", "Wikipedia:Multinucleate" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000228 ; owl:annotatedTarget "A cell with more than one nucleus." . [] oboInOwl:hasDbXref "PMID:31402260", "PMID:32426372", "https://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009107 ; owl:annotatedTarget "A lymphatic endothelial cell located in the subcapsular sinus ceiling of a lymph node. In human, it's characterized by a unique marker expression (NT5e+ and Caveolin-1+)." . [] oboInOwl:hasDbXref "PMID:31402260", "PMID:32426372", "https://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009108 ; owl:annotatedTarget "A lymphatic endothelial cell located in the subcapsular sinus floor of a lymph node. In human, it's characterized by a unique marker expression (TNFRSF9+)." . [] oboInOwl:hasDbXref "PMID:31402260", "PMID:32426372", "https://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009109 ; owl:annotatedTarget "A lymphatic endothelial cell located in a lymph node trabecula." . [] oboInOwl:hasDbXref "PMID:31402260", "PMID:32426372", "https://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009110 ; owl:annotatedTarget "A lymphatic endothelial cell located in the ceiling part of a lymph node medulla." . [] oboInOwl:hasDbXref "PMID:17067937", "https://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009111 ; owl:annotatedTarget "A germinal center B cell found in a lymph node germinal center light zone." . [] oboInOwl:hasDbXref "Wikipedia:Multinucleate" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000228 ; owl:annotatedTarget "multinucleated cells" . [] oboInOwl:hasDbXref "PMID:17067937", "https://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009112 ; owl:annotatedTarget "A germinal center B cell found in a lymph node germinal center dark zone." . [] oboInOwl:hasDbXref "PMID:15578096", "PMID:26501424", "PMID:29769249", "https://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009113 ; owl:annotatedTarget "A regulatory T cell present in the B cell follicles and germinal centers of lymphoid tissues. In humans, it is CXCR5+." . [] oboInOwl:hasDbXref "PMID:33324003", "https://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009114 ; owl:annotatedTarget """A B cell found in the perisinusoidal area of a lymph node. In humans, monocytoid B cells are a morphologically distinct B cell population (oval nuclei, abundant cytoplasm, monocyte-like appearance), share many similarities with marginal zone B cells including marker expression, and are increased in disease settings.""" . [] oboInOwl:hasDbXref "Wikipedia:Multinucleate" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000228 ; owl:annotatedTarget "polynuclear cells" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009115 ; owl:annotatedTarget "An endothelial cell located in a lymph node lymphatic vessel." . [] oboInOwl:hasDbXref "PMID:19063729", "PMID:20346151", "PMID:21930782", "https://orcid.org/0000-0003-4412-7970" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009116 ; owl:annotatedTarget "A progenitor cell with the potential to differentiate into luminal epithelial cells of mammary glands. In mouse, CD61 and c-kit were found to be coexpressed by the majority of, but not all, committed luminal progenitor cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0010000 ; owl:annotatedTarget "A hair follicle matrix region cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the hair bulb to become the hair medulla cortex and hair root sheath." . [] oboInOwl:hasDbXref "GOC:mtg_heart" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0010005 ; owl:annotatedTarget "A specialized cardiomyocyte that transmit signals from the AV node to the cardiac Purkinje fibers." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0010006 ; owl:annotatedTarget "Any blood vessel endothelial cell that is part of some heart." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0010007 ; owl:annotatedTarget "Any cell that is part of some His-Purkinje system." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0010008 ; owl:annotatedTarget "Any endothelial cell that is part of some heart." . [] oboInOwl:hasDbXref "DOI:10.1007/s00441-021-03471-2", "DOI:10.1530/VB-20-0006", "DOI:10.3389/fcvm.2018.00101", "DOI:10.3389/fphys.2018.00382", "DOI:10.3390/ijms20184411" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0010008 ; owl:annotatedTarget """Cardiac endothelial cells are a specialized subset of endothelial cells, the cell type responsible for forming the inner lining of cardiovascular structures such as the heart, and blood vessels. They are a pivotal component of the heart's microenvironment and play a key role in regulating blood pressure, maintaining cardiac homeostasis, in addition to cooperating with other cardiac cells like cardiomyocytes and fibroblasts in the orchestration of a coordinated heart function. Cardiac endothelial cells contribute to the each stage of the heart's operation, whether during relaxation or contraction. Cardiac endothelial cells release nitric oxide, a potent vasodilator that regulates blood vessel dilation consequently controlling blood pressure and flow. They also produce a myriad of growth factors that aid in new blood vessel formation, known as angiogenesis, crucially needed for tissue repair and regeneration when the heart undergoes damage, as in cases of myocardial infarction. Furthermore, cardiac endothelial cells control the passage of nutrients, hormones, and gases between the bloodstream and the heart tissue, ensuring its complex metabolic demands are met adequately. They serve as a selective barrier, regulating the transit of cells and signaling molecules, thereby playing a pivotal role in inflammatory responses and immune cell trafficking. They also contribute to the maintenance of blood fluidity and clotting balance through a complex interplay of anti-thrombic and pro-thrombic factors. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "cardiac endothelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0010008 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0010008" . [] a owl:Axiom ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/2245" ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0010009 ; owl:annotatedTarget _:genid11713 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0010009 ; owl:annotatedTarget "Any photoreceptor cell that is part of some camera-type eye." . [] oboInOwl:hasDbXref "PMID:31110133", "PMID:5042759" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0010010 ; owl:annotatedTarget "A GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell receives excitatory inputs primarily from parallel fibers and plays a crucial role in feed-forward inhibition by suppressing the activity of Purkinje cells and modulating the output of the cerebellar cortex. The stellate cell is part of the local circuitry that contributes to the fine-tuning of motor coordination and a regulator of cerebellar blood flow via neurovascular coupling." . [] oboInOwl:hasDbXref "PMID:31110133" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0010010 ; owl:annotatedTarget "cerebellar SC" . [] dc:license ; oboInOwl:hasDbXref "doi:10.1016/j.cnp.2022.11.002" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0010010 ; owl:annotatedTarget . [] dc:license ; oboInOwl:hasDbXref "doi:10.3389/fnins.2020.00293" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0010010 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0010011 ; owl:annotatedTarget "A GABAergic interneuron whose soma is located in the cerebral cortex." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0010012 ; owl:annotatedTarget "A CNS neuron of the cerebral cortex." . [] oboInOwl:hasDbXref "GOC:mr", "PMID:17595538" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0010015 ; owl:annotatedTarget "A highly specialized cell type exclusive to and forming neuroepithelium of the Saccus vasculosus, covering the caudal diverticulum of the infundibular recess." . [] oboInOwl:hasDbXref "PMID:25840473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0010016 ; owl:annotatedTarget "A cell with a flagellum surrounded by a collar of microvilli. The motion of the flagellum draws water past the microvilli, serving either a feeding or sensory function. Collar cells are found in multiple animals, including sponges, echinoderms, and cnidarians. They are also found outside animals in the choanoflagellates. Although collar cells are superficially similar, their cytoskeletal structure and functional biology are different in different groups of organisms." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0010020 ; owl:annotatedTarget "Any glial cell that is part of some heart." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0010021 ; owl:annotatedTarget "Any myoblast that develops into some cardiac muscle cell." . [] oboInOwl:hasDbXref "PMID:12486170", "PMID:29265764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0010022 ; owl:annotatedTarget "A neuron that has its soma in the heart." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0011000 ; owl:annotatedTarget obo:CL_0005000 . [] oboInOwl:hasDbXref "GOC:nv" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011000 ; owl:annotatedTarget "A CNS interneuron located in the dorsal horn of the spinal cord." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0011001 ; owl:annotatedTarget obo:CL_0000100 . [] oboInOwl:hasDbXref "GOC:nv" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011001 ; owl:annotatedTarget "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." . [] oboInOwl:hasDbXref "GOC:nv" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011002 ; owl:annotatedTarget "A motor neuron that is generated only on limb levels and send axons into the limb mesenchyme." . [] oboInOwl:hasDbXref "GOC:nv", "MP:0009467", "PMID:10711808" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011003 ; owl:annotatedTarget "A neurosecretory neuron residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, that is capable of secreting the hormones oxytocin or vasopressin, and sometimes both, into the systemic circulation." . [] oboInOwl:hasDbXref "GO:0070307", "GOC:nv" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011004 ; owl:annotatedTarget "A vetebrate lens cell that is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." . [] oboInOwl:hasDbXref "DOI:10.1016/j.exer.2016.03.016", "DOI:10.1016/j.pbiomolbio.2003.11.012", "DOI:10.1098/rstb.2010.0300", "DOI:10.1242/dev.107953", "https://www.sciencedirect.com/topics/immunology-and-microbiology/lens-fiber" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0011004 ; owl:annotatedTarget """Lens fiber cells are specialized, elongated cells located in the ocular lens, an important part of the eye responsible for focusing light onto the retina to create clear defined images. These cells are unique among body cells, as they are transparent and filled with a clear protein called crystallin to facilitate the passage of light. The entire life cycle of a lens fiber cell includes differentiation from lens epithelial cells, which are the progenitor cells lying at the anterior surface of the lens. In response to various signals, these cells elongate and migrate towards the posterior pole, while simultaneously undergoing a process of denucleation and degradation of cellular organelles. This unique process ensures that the cells do not scatter light, which is critical for the transparency of the lens. After reaching full maturity, lens fiber cells form tightly packed layers, known as laminae, to make up the distinctive architecture of the ocular lens. Lens fiber cells play pivotal roles in vision. Their primary function is to transmit and focus the light that enters the eye onto the retina, providing the sharpness and clarity necessary for vision. The precise alignment and organization of these cells allow for optimal light transmittance and minimizes scattering, thereby maintaining the transparency of the lens. As such, disruptions or abnormalities in lens fiber cells can lead to serious vision impairment, including conditions like cataracts, a common condition characterized by the opacification of the lens. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0011004 ; owl:annotatedTarget "ZFA:0009401" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "lens fiber cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0011004 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0011004" . [] oboInOwl:hasDbXref "GOC:CellBLAST", "GOC:nv", "PMID:29724907" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011005 ; owl:annotatedTarget "An interneuron that uses GABA as a vesicular neurotransmitter. These interneurons are inhibitory" . [] oboInOwl:hasDbXref "GOC:nv", "PMID:18677503", "PMID:2273099" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011006 ; owl:annotatedTarget "A cerebellar interneuron characterized by a spindle-shaped or triangular soma, parasagittally oriented and located at the border between the granular layer and the Purkinje cell layer. The Lugaro cell extends dendrites predominantly in the parasagittal plane, forming synaptic interactions with basket, stellate, and Golgi cells. Its axonal projections extend upward into the molecular layer, where they form a parasagittal plexus and emit long transverse collaterals that run parallel to the long axis of the cerebellar folia. The Lugaro cell is capable of co-releasing GABA and glycine, as evidenced by the expression of glutamate decarboxylase (GAD65/67) and the glycine transporter GlyT2." . [] oboInOwl:hasDbXref "PMID:34194302" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0011006 ; owl:annotatedTarget "globular cell" . [] dc:license ; oboInOwl:hasDbXref "doi:10.1016/j.cnp.2022.11.002" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0011006 ; owl:annotatedTarget . [] dc:license ; oboInOwl:hasDbXref "doi:10.3389/fnins.2020.00293" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0011006 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "GOC:NV", "PMID:11687492" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011007 ; owl:annotatedTarget "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites." . [] oboInOwl:hasDbXref "GOC:NV", "PMID:17967061" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011008 ; owl:annotatedTarget "A hemocyte derived from the embryonic head mesoderm, which enters the hemolymph as a circulating cell." . [] oboInOwl:hasDbXref "GOC:NV", "PMID:17967061" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011009 ; owl:annotatedTarget "A plasmatocyte derived from the embryonic head mesoderm." . [] oboInOwl:hasDbXref "GOC:NV", "PMID:9169844" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011010 ; owl:annotatedTarget "A cell derived from the mesoderm that is found at the periphery of the embryo." . [] oboInOwl:hasDbXref "GOC:NV", "ISBN:978-0-87969-707-5" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011011 ; owl:annotatedTarget "A cell derived from the mesoderm that is located between the paraxial mesoderm and the lateral plate." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-5208-3432", "https://orcid.org/0000-0002-9900-7880" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011012 ; owl:annotatedTarget "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." . [] oboInOwl:hasDbXref "DOI:10.1002/dvg.23276", "DOI:10.1242/dev.193193", "DOI:10.3389/fcell.2020.00635/full", "https://doi.org/10.1016/j.ydbio.2011.12.042" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0011012 ; owl:annotatedTarget """Neural crest cells are a group of transient and highly migratory cells that originate from the neuroectoderm during the early stages of embryonic development. They are multipotent cells with an exceptional degree of plasticity, capable of differentiating into various somatic cell types and therefore play a fundamental role in the formation of various organs and tissues, making them critical contributors to the developing embryo. After the initiation of neurulation (the formation of the neural tube) neural crest cells start to undergo epithelial-to-mesenchymal transition and delaminate and migrate from the dorsal neural tube to several regions throughout the embryo. They differentiate into a range of diverse cell types, such as neurons and glial cells of the peripheral nervous system, including sensory and autonomic neurons. They also contribute to the formation of adrenal glands, pigment cells in the skin (melanocytes), cardiac structures, including parts of the heart septum and major arteries, as well as bones and cartilage of the face and skull. Disorders or aberrations in the development or migration of the neural crest cells can lead to serious congenital malformations, such as neurocristopathies, including Hirschsprung disease, neuroblastoma, and neurofibromatosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "neural crest cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0011012 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0011012" . [] oboInOwl:hasDbXref "PMID:30612620" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011013 ; owl:annotatedTarget "A sperm cell that is cabaple of motion (motility)." . [] oboInOwl:hasDbXref "PMID:30612620" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011014 ; owl:annotatedTarget "A sperm cell that is not cabaple of motion (motility)." . [] oboInOwl:hasDbXref "PMID:17708982" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011015 ; owl:annotatedTarget "A motile sperm cell that contain no F-actin, and their motility is powered by a dynamic filament system." . [] oboInOwl:hasDbXref "PMID:30612620", "https://www.lexico.com/en/definition/flagellum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011016 ; owl:annotatedTarget "A motile sperm cell that contains a slender threadlike microscopic appendage that enables motion." . [] oboInOwl:hasDbXref "PMID:22016183" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011017 ; owl:annotatedTarget "Cell that is part of the vagal neural crest population. The vagal neural crest arises from the axial level of somites 1-7 and has been described as a hybrid between the head and the trunk populations." . [] oboInOwl:hasDbXref "GOC:add", "PMID:19029905", "PMID:21601793", "PMID:27935637", "PMID:29454785", "PMID:9354470" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011018 ; owl:annotatedTarget "A group 3 innate lymphoid cell that express ROR gamma t and IL-7R alpha in the absence of lineage markers (e.g. CD3, CD19, B220, CD11c, Gr-1), with the functional ability to interact with mesenchymal cells through lymphotoxin and tumor necrosis factor. Lymphoid tissue-inducer cells are key to the development of lymph nodes and Peyer’s patches." . [] oboInOwl:hasDbXref "PMID:23064725", "PMID:30574073", "PMID:37508487" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011020 ; owl:annotatedTarget "An undifferentiated cell derived from a neural stem cell, with a limited capacity to self-renew (Dibajnia and Morshead, 2013) and the ability to generate multiple types of lineage-restricted progenitors, contributing to the formation of neurons, astrocytes, and oligodendrocytes." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000232 ; owl:annotatedTarget obo:CL_0000764 . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D004912" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000232 ; owl:annotatedTarget "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." . [] oboInOwl:hasDbXref "PMID:16285891" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011024 ; owl:annotatedTarget "A double negative thymocyte that is CD3-positive, CD4-negative, CD8-negative, that that are present in the periphery in very low numbers and predominantly produce INF-gamma, TNF-alpha, and a low amount of TGF-beta, but not IL-2, IL-4, IL-10 or IL-13 upon activation." . [] oboInOwl:hasDbXref "PMID:26544946" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011025 ; owl:annotatedTarget "An effector T cell that displays impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity) and has limited proliferative potential." . [] oboInOwl:hasDbXref "ISBN:978-1-62808-994-3", "https://doi.org/10.1016/B978-0-12-409503-8.00002-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011026 ; owl:annotatedTarget "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." . [] oboInOwl:hasDbXref "PMID:28369879", "https://orcid.org/0000-0001-6164-0667" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011027 ; owl:annotatedTarget "Any fibroblast that is part of skeletal muscle tissue." . [] oboInOwl:hasDbXref "DOI:10.1016/j.diff.2016.05.007", "DOI:10.1186/s13578-021-00579-4", "DOI:10.1186/s13578-022-00856-w" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0011027 ; owl:annotatedTarget """Skeletal muscle fibroblasts (SMFs), with their spindle-shaped morphology, play a crucial role in maintaining the structure and function of skeletal muscles. They produce connective tissues enveloping muscle fibers, offering vital structural support for optimal muscle contraction. SMFs are integral components of the dynamic and complex microenvironment of muscle tissue, contributing significantly to healthy muscle development and homeostasis. SMFs primarily synthesize and secrete extracellular matrix (ECM) components, such as collagen, fibronectin, and proteoglycans. The resulting ECM exhibits mechanical properties that resist tensile forces from muscle contractions, ensuring muscle efficiency. It also crucially transmits force during muscle movement, aids muscle attachment to the skeletal structure, and serves as a scaffold for muscle regeneration and repair. Following injury, they proliferate and transform into myofibroblasts, aiding wound contraction and depositing new ECM for tissue repair. Additionally, these fibroblasts modulate inflammatory responses by secreting cytokines and interact with other cell types, like immune cells and satellite cells, to coordinate muscle healing. In diseases, an imbalance in SMF activity may lead to conditions such as fibrosis, marked by excessive ECM deposition and impaired muscle function. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "skeletal muscle fibroblast on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0011027 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0011027" . [] oboInOwl:hasDbXref "PMID:22456085" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011028 ; owl:annotatedTarget "A neural-crest derived glial cell that supports the growth and survival of primary olfactory neuroons from the neuroepithelium in the nasal cavity to the brain by encasing large bundles of numerous unmyelinated axons." . [] oboInOwl:hasDbXref "https://en.wikipedia.org/wiki/Cnidocyte", "https://orcid.org/0000-0002-2825-0621" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011029 ; owl:annotatedTarget "An explosive cell containing one giant secretory organelle called a cnidocyst (also known as a cnida (plural cnidae) or nematocyst) that contains a toxin responsible for the stings delivered by a cnidarian to other organisms. Cnidae are used to capture prey and as a defense against predators. The presence of cnidocytes defines the phylum Cnidaria (corals, sea anemones, hydrae, jellyfish, etc.)." . [] oboInOwl:hasDbXref "BTO:0004574", "CL:patterns/cellPartOfAnatomicalEntity" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011030 ; owl:annotatedTarget "Any microvascular endothelial cell that is part of the dermis." . [] oboInOwl:hasDbXref "BTO:0002900", "PMID:30719026", "PMID:32733468" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011031 ; owl:annotatedTarget "A dendritic cell that develops from a monocyte." . [] oboInOwl:hasDbXref "PMID:31474562", "https://orcid.org/0000-0002-1009-339X", "https://orcid.org/0000-0002-2244-7917" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011032 ; owl:annotatedTarget "An enterocyte that possesses a large supranuclear vacuolar system that preferentially internalizes dietary protein via receptor-mediated and fluid-phase endocytosis for intracellular digestion and trans-cellular transport. In zebrafish these cells are located in the posterior region of the mid intestine throughout life. In mammals they are found in the ileum pre-weaning and later are replaced by mature enterocytes." . [] oboInOwl:hasDbXref "PMID:33290721", "https://orcid.org/0000-0001-9610-7627" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0011032 ; owl:annotatedTarget "early enterocyte" . [] oboInOwl:hasDbXref "PMID:33290721", "https://orcid.org/0000-0001-9610-7627" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0011032 ; owl:annotatedTarget "immature enterocyte" . [] oboInOwl:hasDbXref "GOC:NV", "PMID:23159249", "ZFIN:CVS", "ZFIN:YB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011100 ; owl:annotatedTarget "Neuron that secretes the neurotransmitter galanin." . [] oboInOwl:hasDbXref "GOC:NV" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011101 ; owl:annotatedTarget "Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." . [] oboInOwl:hasDbXref "DOI:10.1007/s00018-019-03104-6", "DOI:10.1093/biolre/ioy070", "DOI:10.1155/2014/579279", "https://www.ncbi.nlm.nih.gov/books/NBK53245/", "https://www.sciencedirect.com/topics/medicine-and-dentistry/placenta-development" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0011101 ; owl:annotatedTarget """The chorionic trophoblast cell, vital for placental development in mammals, originates from the blastocyst's outer layer, the trophectoderm. As a significant component of the placenta, the chorion forms the external fetal-maternal interface and consists primarily of chorionic trophoblast cells. These cells are pivotal in embryogenesis, fetal nutrition, waste removal, and immune response generation, contributing crucially to the success of pregnancy. Chorionic trophoblast cells undergo trophoblast differentiation, giving rise to specialized sub-types: cytotrophoblasts and syncytiotrophoblasts. Cytotrophoblasts, found in the inner layer, serve as stem cells and contribute to proliferative activities. In contrast, syncytiotrophoblasts, originating from cytotrophoblasts, form the outer layer with a distinctive multinucleated, continuous, and non-proliferative structure. These cells play a key role in maternal-fetal gas and nutrient exchange, producing essential hormones like human chorionic gonadotropin (hCG), progesterone, and estrogen, vital for sustaining pregnancy. Apart from their physiological roles, chorionic trophoblast cells play a crucial role in shielding the fetus from the maternal immune system. They accomplish this by modifying the expression of major histocompatibility complex (MHC) molecules, which are self-identifying proteins utilized by the immune system to identify foreign cells. Through selective expression of specific types of these molecules, trophoblast cells can evade cytotoxic T cells that might otherwise attack them, while still retaining the ability to attract natural killer cells. These natural killer cells assist in trophoblast invasion and the remodeling of blood vessels in the uterus. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "chorionic trophoblast cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0011101 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0011101" . [] oboInOwl:hasDbXref "GOC:NV", "isbn:0080923437" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011102 ; owl:annotatedTarget "Parasympathetic neurons are part of the parasympathetic nervous sysem and the cell bodies lie in the brain and sacral region of the spinal cord. The neurons are mainly cholinergic." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000233 ; owl:annotatedTarget obo:CL_0000763 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0011102 ; owl:annotatedTarget "ZFA:0005776" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:NV", "isbn:0080923437" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011103 ; owl:annotatedTarget "Sympathetic neurons are part of the sympathetic nervous system and are primarily adrenergic producing the neurotransmitter noradrenalin along with other neuropeptides." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0011103 ; owl:annotatedTarget "ZFA:0005777" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:NV", "PMID:12771169" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011104 ; owl:annotatedTarget """A type of interneuron in the retinal inner nuclear layer which carries information from the inner plexiform layer and the outer plexiform layer.""" . [] oboInOwl:hasDbXref "GOC:NV", "PMID:12771169" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011105 ; owl:annotatedTarget """A type of interneuron in the retinal inner nuclear layer which carries information from the inner plexiform layer and the outer plexiform layer, using dopamine.""" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "MESH:D001792", "PMID:11110672", "PMID:16987572", "PMID:17204662", "PMID:17479180", "PMID:20414831", "http://en.wikipedia.org/wiki/Platelet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000233 ; owl:annotatedTarget "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." . [] oboInOwl:hasDbXref "GOC:NV", "PMID:12771169" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011106 ; owl:annotatedTarget """A type of interneuron in the retinal inner nuclear layer which carries information from the inner plexiform layer and the outer plexiform layer using GABA.""" . [] oboInOwl:hasDbXref "GOC:NV", "PMID:21911394" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011107 ; owl:annotatedTarget "OBSOLETE: Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer." . [] oboInOwl:hasDbXref "GOC:NV" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011108 ; owl:annotatedTarget "Epithelial cell that is part of the colon epithelium." . [] oboInOwl:hasDbXref "GOC:NV", "PMID:23848055" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011109 ; owl:annotatedTarget "A neuron that releases hypocretin as a neurotransmitter." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0011109 ; owl:annotatedTarget "ZFA:0005778" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:NV", "PMID:22677810" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011110 ; owl:annotatedTarget "Neuron that secretes histamine." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0011110 ; owl:annotatedTarget "FBbt:00007367" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:NV", "PMID:20807514", "PMID:21828096", "PMID:26053743", "PMID:34128468", "PMID:35067985" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011111 ; owl:annotatedTarget "a specialized neuroendocrine cell that synthesizes and secretes GnRH decapeptide, a key regulator of reproductive function. It originates from the olfactory placode during embryonic development and migrates into the forebrain where it localises predominantly in the hypothalamus and in humans, in extrahypothalamic regions like the basal ganglia (Skrapits et al., 2021). This cell regulates reproduction by secreting GnRH into the pituitary portal vessels to induce the release of gonadotropins into the general circulation. It expresses receptor subunits required for AMPA, NMDA, and kainate receptor signaling and may use glutamate as a neurotransmitter in recurrent collateral innervation." . [] oboInOwl:hasDbXref "GOC:NV", "PMID:10711808" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011112 ; owl:annotatedTarget "OBSOLETE: Neurons part of the hypothalamic supraoptic and paraventricular nuclei that secrete the hormones, oxytocin and vasopressin into the systemic circulation from the posterior pituitary gland." . [] oboInOwl:hasDbXref "GOC:NV" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011113 ; owl:annotatedTarget "Neuron found in the spiral ganglion." . [] oboInOwl:hasDbXref "PMID:11138622", "PMID:15514007" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011114 ; owl:annotatedTarget "A segmented neutrophilic cell of the bone marrow reserve pool that expresses CD11b (integrin alpha-M) and high levels of CD16 (low affinity immunoglobulin gamma Fc region receptor III) on its cell surface." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011115 ; owl:annotatedTarget "A cell that, by division or terminal differentiation, can give rise to other cell types." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0012000 ; owl:annotatedTarget obo:CL_0000127 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0013000 ; owl:annotatedTarget "Any radial glial cell that is part of some forebrain." . [] oboInOwl:hasDbXref "ZFIN:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0015000 ; owl:annotatedTarget "Motor neuron that innervate muscles that control eye, jaw, and facial movements of the vertebrate head and parasympathetic neurons that innervate certain glands and organs." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000234 ; owl:annotatedTarget "Any cell capable of ingesting particulate matter via phagocytosis." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0015000 ; owl:annotatedTarget "ZFA:0005730" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:30069044", "PMID:30069046" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017000 ; owl:annotatedTarget "An ionocyte that is part of the lung epithelium. The cells from this type are major sources of the CFTR protein in human and mice." . [] oboInOwl:hasDbXref "DOI:10.1038/s41586-018-0393-7", "DOI:10.1146/annurev-pathol-042420-094031", "DOI:10.1172/JCI171268" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0017000 ; owl:annotatedTarget """The pulmonary ionocyte is a relatively newly identified, specific epithelial cell type found primarily in the pulmonary or respiratory system. Discovered through novel mapping techniques in 2018, these cells are surprisingly rare, making up less than 2% of the cells in the lung's airway, yet they play an essential role in the airway surface liquid and mucus regulation, a crucial factor in lung health. The main responsibility of the pulmonary ionocyte pertains to the regulation and mobilization of chloride ions. They express a high level of CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene, which encodes a protein channel across the membrane of cells that produce mucus, sweat, saliva, tears, and digestive enzymes. The activity of CFTR regulates the movement of chloride ions and fluids in and out of cells, which helps maintain a balance of fluid in the organs they are expressed in. If CFTR is dysfunctional, it can cause conditions such as cystic fibrosis, characterized by thick, sticky mucus that can clog the lungs and obstruct the pancreas, leading to respiratory and digestive issues. The discovery of this cell type offers new doors to the treatment and further understanding of diseases like cystic fibrosis. Increased understanding of pulmonary ionocytes could contribute to the development of novel therapeutic approaches to manipulate the function of CFTR in the lungs and other organs affected by dysfunctional CFTR. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0017000 ; owl:annotatedTarget "The marker set ASCL3, BSND can identify the Human cell type pulmonary ionocyte in the lung with a confidence of 0.82 (NS-Forest FBeta value)." . [] a owl:Axiom ; rdfs:label "pulmonary ionocyte on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0017000 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0017000" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000234 ; owl:annotatedTarget "ZFA:0009140" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:33842835", "http://orcid.org/0000-0001-7772-9578" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017002 ; owl:annotatedTarget "A neuroendocrine cell that is part of the prostate epithelium." . [] oboInOwl:hasDbXref "PMID:30566875" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017003 ; owl:annotatedTarget "An epithelial cell that is part of the prostatic urethra." . [] oboInOwl:hasDbXref "MESH:D000067170", "PMID:20367664", "PMID:28714595", "PMID:31311805", "https://en.wikipedia.org/wiki/Telocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017004 ; owl:annotatedTarget "A supportive cell with a small, oval-shaped body and one to five telopodes. Telopodes are cytoplasmic protrusions from tens to hundreds of micrometers long and mostly below 0.2 microns of caliber." . [] oboInOwl:hasDbXref "PMID:20367664" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_0017004 ; owl:annotatedTarget "interstitial Cajal cell-like cell" . [] oboInOwl:hasDbXref "PMID:20367664" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_0017004 ; owl:annotatedTarget "interstitial Cajal-like cell" . [] oboInOwl:hasDbXref "PMID:20367664" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0017004 ; owl:annotatedTarget "ICLC" . [] oboInOwl:hasDbXref "PMID:31311805" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0017004 ; owl:annotatedTarget "interstitial neuron" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0017004 ; owl:annotatedTarget "Telocytes manage to develop complex networks in almost all organs of the human body. Although staining positively for vimentin antibody, some uncertainty still persists over the mesenchymal origin of these cells." . [] oboInOwl:hasDbXref "NCIT:C13013", "http://orcid.org/0000-0001-9990-8331" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017005 ; owl:annotatedTarget "A lymphocyte that has gotten larger after being stimulated by an antigen." . [] oboInOwl:hasDbXref "EFO:0005293", "https://orcid.org/0000-0002-2825-0621" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017006 ; owl:annotatedTarget "A lymphocyte of B lineage that has gotten larger after being stimulated by an antigen." . [] oboInOwl:hasDbXref "PMID:28428369", "PMID:29221729", "PMID:31156637" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017009 ; owl:annotatedTarget "A human dendritic cell that expresses the AXL and SIGLEC6 genes." . [] oboInOwl:hasDbXref , "PMID:30566875" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017010 ; owl:annotatedTarget "A hillock cell that is part of the urethra." . [] oboInOwl:hasDbXref , "PMID:30566875" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017011 ; owl:annotatedTarget "A hillock cell that is part of the prostatic urethra." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017500 ; owl:annotatedTarget "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017501 ; owl:annotatedTarget "Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017502 ; owl:annotatedTarget "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017503 ; owl:annotatedTarget "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017504 ; owl:annotatedTarget "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017505 ; owl:annotatedTarget "OBSOLETE. A nucleus size quality which is relatively high compared to the amount of cytoplasm present in the same cell." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017506 ; owl:annotatedTarget "A concave nuclear shape where the nucleus is indented to more than half the distance to the farthest nuclear margin, but in no area is the chromatin condensed to a single filament." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017507 ; owl:annotatedTarget "A concave nucleus shape where the indentation is smaller than half of the distance to the farthest nuclear margin." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017508 ; owl:annotatedTarget "Heterochromatin that is arranged in a carthwheel pattern." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017509 ; owl:annotatedTarget "Any nucleus that has characteristic some alobate." . [] oboInOwl:hasDbXref "DOI:10.1016/j.resp.2007.06.017", "DOI:10.1113/jphysiol.2003.052779", "DOI:10.1146/annurev.ph.52.030190.000525", "DOI:10.1152/ajplung.00068.2019" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0019001 ; owl:annotatedTarget """Serous cells of the tracheobronchial are found on the surface epithelium, submucosal glands, or both, depending on species. They appear in tubulo-acinar arrangements in submucosal glands. Tracheobronchial serous cells play a vital role in maintaining respiratory health by secreting serous fluid, which is rich in enzymes, ions, and antimicrobial proteins. This serous fluid is essential in clearing out debris, trapping and neutralizing inhaled pathogens and particulate matters, thereby helping in preventing infections. Their secretory products also include water and electrolytes that, combined with mucus (from mucous cells), maintain proper humidity within the airway and lubricate its surfaces, facilitating unhindered airflow. Dysfunction of these cells may lead to diseases such as cystic fibrosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "tracheobronchial serous cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0019001 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0019001" . [] oboInOwl:hasDbXref "PMID:27548519" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019015 ; owl:annotatedTarget "An eosinophil with a ring-shaped nucleus that is resident in the lung parenchyma. In mouse, lung parenchyma resident eosinophils are IL-5-independent Siglec-F(intermediate) CD62L+ CD101(low). In human, they are Siglec-8+ CD62L+ IL-3R(low)." . [] oboInOwl:hasDbXref "PMID:27548519" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019015 ; owl:annotatedTarget "lung-resident eosinophil" . [] oboInOwl:hasDbXref "PMID:27548519" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019015 ; owl:annotatedTarget "rEos" . [] oboInOwl:hasDbXref "PMID:15109561" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019017 ; owl:annotatedTarget "A smooth muscle cell that is part of any lymphatic vessel." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000235 ; owl:annotatedTarget obo:CL_0000766 . [] oboInOwl:hasDbXref "PMID:9108778" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019018 ; owl:annotatedTarget "A smooth muscle cell that is part of any blood vessel." . [] oboInOwl:hasDbXref "PMID:10853867" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019019 ; owl:annotatedTarget "A smooth muscle cell that is part of the tracheobronchial tree." . [] oboInOwl:hasDbXref "DOI:10.1007/978-3-540-79090-7_5", "DOI:10.1152/japplphysiol.00950.2012", "https://www.ncbi.nlm.nih.gov/books/NBK556044/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0019019 ; owl:annotatedTarget """Tracheobronchial smooth muscle cells are universally located in the tracheobronchial tree and play a critical role in controlling and modulating the size of the airway lumen, thereby contributing significantly to the airflow resistance. These cells display both phasic and tonic characteristics, which are vital for airway contractility. Phasic activity manifests as cyclic contraction and relaxation, similar to the behavior seen in gastrointestinal smooth muscle cells, whilst tonic activity resembles vascular smooth muscle cells, maintaining a constant degree of tension. These features enable tracheobronchial smooth muscle cells to constrict the airways in response to various mechanical and chemical stimuli, including allergens, parasympathetic nervous stimulation, changes in gas composition, and cold air, thus protecting the delicate alveoli from potential damage. Tracheobronchial smooth muscle cells, beyond their contractile function, actively contribute to airway remodeling in conditions like asthma. Their proliferative and synthetic capabilities lead to smooth muscle hypertrophy, hyperplasia, and the production of extracellular matrix components, collectively causing abnormal airway narrowing. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "PMID:16213494", "PMID:1919437" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000235 ; owl:annotatedTarget "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0019019 ; owl:annotatedTarget "The marker set ACTA2, TAGLN can identify the Human cell type tracheobronchial smooth muscle cell in the lung with a confidence of 0.69 (NS-Forest FBeta value)." . [] a owl:Axiom ; rdfs:label "tracheobronchial smooth muscle cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0019019 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0019019" . [] oboInOwl:hasDbXref "PMID:23720296" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019020 ; owl:annotatedTarget "An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes." . [] oboInOwl:hasDbXref "PMID:23720296" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019020 ; owl:annotatedTarget "large bile duct cholangiocyte" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000235 ; owl:annotatedTarget "ZFA:0009141" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:27423426" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019021 ; owl:annotatedTarget "An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid." . [] oboInOwl:hasDbXref "PMID:28287163" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019021 ; owl:annotatedTarget "periportal LSEC" . [] oboInOwl:hasDbXref "PMID:30348985" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019021 ; owl:annotatedTarget "periportal hepatic sinusoidal endothelial cell" . [] oboInOwl:hasDbXref "PMID:27423426" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019022 ; owl:annotatedTarget "An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid." . [] oboInOwl:hasDbXref "PMID:30348985" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019022 ; owl:annotatedTarget "central venous hepatic sinusoidal endothelial cell" . [] oboInOwl:hasDbXref "PMID:28287163" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019022 ; owl:annotatedTarget "pericentral LSEC" . [] oboInOwl:hasDbXref "PMID:29763190" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019026 ; owl:annotatedTarget "Any hepatocyte that is part of the liver lobule periportal region. These cells are primarily involved in oxidative energy metabolism." . [] oboInOwl:hasDbXref "PMID:29763190" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019026 ; owl:annotatedTarget "periportal hepatocyte" . [] oboInOwl:hasDbXref "PMID:29763190" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019028 ; owl:annotatedTarget "Any hepatocyte that is part of the liver lobule midzonal region. These cells have mixed functionality in comparison with those in the other two regions of the liver lobule." . [] oboInOwl:hasDbXref "PMID:29763190" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019028 ; owl:annotatedTarget "midzonal hepatocyte" . [] oboInOwl:hasDbXref "PMID:29763190" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019029 ; owl:annotatedTarget "Any hepatocyte that is part of the liver lobule centrilobular region. These cells are the primary location for the biotransformation of drugs." . [] oboInOwl:hasDbXref "PMID:29763190" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019029 ; owl:annotatedTarget "centrilobular hepatocyte" . [] oboInOwl:hasDbXref "PMID:1996606", "PMID:24942678", "PMID:33484640" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019031 ; owl:annotatedTarget "Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3." . [] oboInOwl:hasDbXref "PMID:1996606" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019031 ; owl:annotatedTarget "intestinal goblet cell" . [] oboInOwl:hasDbXref "PMID:22527717", "PMID:29714721", "PMID:35237268", "PMID:39358509" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019032 ; owl:annotatedTarget "A tuft cell that is part of the intestinal epithelium, characterized by a distinctive apical tuft and lateral cytospinules connecting to neighbouring cells. This cell senses luminal stimuli via taste receptors and succinate signalling, initiating type 2 immune responses through the secretion of interleukin-25 while modulating epithelial regeneration through prostaglandin synthesis. It expresses key molecular markers such as doublecortin-like kinase 1 (DCLK1) in mice (Hendel et al., 2022), and KIT proto-oncogene in humans (Huang et al., 2024). Developed from intestinal crypt stem cells, this cell requires transcription factor POU2F3 for its development." . [] oboInOwl:hasDbXref "PMID:22527717" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019032 ; owl:annotatedTarget "intestinal brush cell" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM294.HJJZ.279" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0019032 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/large-intestine-crypt-lieberkuhn/v1.2/assets/2d-ftu-large-intestine-crypt-lieberkuhn.png" . [] oboInOwl:hasDbXref "PMID:24051376", "PMID:31300091", "PMID:32016094" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0700009 ; owl:annotatedTarget "OBSOLETE. A renal beta-intercalated cell that is part of the cortical collecting duct. The medullary collecting duct does not contain the renal beta-intercalated cell type." . [] oboInOwl:hasDbXref "PMID:32016094" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0700009 ; owl:annotatedTarget "B-IC" . [] oboInOwl:hasDbXref "PMID:31300091" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0700009 ; owl:annotatedTarget "kidney collecting duct intercalated cell type B" . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000001 ; owl:annotatedTarget "Any neuron that has its soma located in some retrotrapezoid nucleus." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000236 ; owl:annotatedTarget obo:CL_0000945 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000022 ; owl:annotatedTarget "Any epithelial cell that is part of some mesonephric nephron tubule." . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000236 ; owl:annotatedTarget "A lymphocyte of B lineage that is capable of B cell mediated immunity." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000042 ; owl:annotatedTarget "Any neuroblast (sensu Vertebrata) that is part of some forebrain." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000050 ; owl:annotatedTarget "Any glial cell that is part of some lateral line nerve." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000236 ; owl:annotatedTarget "ZFA:0009142" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000073 ; owl:annotatedTarget "Any radial glial cell that is part of some spinal cord." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_1000082 ; owl:annotatedTarget "ZFA:0009370" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_1000083 ; owl:annotatedTarget "ZFA:0009371" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000090 ; owl:annotatedTarget "Any epithelial cell that is part of some pronephric nephron tubule." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000123 ; owl:annotatedTarget "Any epithelial cell that is part of some metanephric nephron tubule." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000143 ; owl:annotatedTarget "Any goblet cell that is part of some lung epithelium." . [] oboInOwl:hasDbXref "DOI:10.1038/s41385-018-0039-y", "DOI:10.1038/s41385-020-00370-7", "DOI:10.1159/000512268", "DOI:10.1513/AnnalsATS.201802-128AW", "https://www.ncbi.nlm.nih.gov/books/NBK553208/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000143 ; owl:annotatedTarget """Lung goblet cells are critical components of the respiratory tract, specifically found in the bronchial segments. They are secretory epithelial cells known for their signature \"goblet\" or cup-like shape. Their primary function is to produce and secrete mucus that aids in trapping airborne particles and pathogens, preventing them from reaching the delicate environment of the lung. As part of the lung's epithelial lining, they act as frontline defenders, maintaining lung health and function. The lung goblet cells are densely packed with granules containing mucin glycoproteins, the primary component of mucus. As mucus is produced and secreted, it moves towards the lumen of the lungs where the cilia, hair-like structures of the neighboring ciliated epithelial cells, help to navigate it upwards and out of the respiratory tract. This coordinated action ensures the expulsion of unwanted particles and pathogens, effectively cleaning the respiratory tract. Dysfunction or abnormal proliferation of lung goblet cells can result in pathological conditions such as chronic obstructive pulmonary disorder (COPD) and asthma, where excessive mucus production leads to airway obstruction. Furthermore, lung goblet cells respond to a variety of stimuli, including toxins, allergens, irritants, and infections, adjusting their mucus production accordingly. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "lung goblet cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000143 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000143" . [] oboInOwl:hasDbXref "PMID:25311230" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000147 ; owl:annotatedTarget "A cell that is part of a cardiac valve." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_1000147 ; owl:annotatedTarget "ZFA:0009402" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:30796046" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000147 ; owl:annotatedTarget "heart valve cell" . [] oboInOwl:hasDbXref "GO:0061330" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000155 ; owl:annotatedTarget "A specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_1000155 ; owl:annotatedTarget "FBbt:00005797" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FBbt:00005797" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000155 ; owl:annotatedTarget "Malpighian tubule Type II cell" . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000182 ; owl:annotatedTarget "Any tip cell that is part of some Malpighian tubule." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12417662" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000191 ; owl:annotatedTarget "A rod-like cell in the inner ear, having their heads joined and their bases on the basilar membrane widely separated so as to form a spiral tunnel known as the tunnel of Corti." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000217 ; owl:annotatedTarget "Any chondrocyte that is part of some growth plate cartilage." . [] oboInOwl:hasDbXref "PMID:15153415" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000222 ; owl:annotatedTarget "A specialised neuroendocrine cell located in the gastric mucosa that regulates digestive processes including acid secretion and gut motility. This cell stores hormones in large dense core vesicles and synaptic-like microvesicles." . [] oboInOwl:hasDbXref "PMID:15153415" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_1000222 ; owl:annotatedTarget "DES cell" . [] oboInOwl:hasDbXref "PMID:15153415" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_1000222 ; owl:annotatedTarget "diffuse endocrine system cell" . [] oboInOwl:hasDbXref "PMID:33355253", "doi:10.3109/01902148209069653", "doi:10.7554/eLife.78216" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000223 ; owl:annotatedTarget "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Pulmonary neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Pulmonary neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." . [] oboInOwl:hasDbXref "DOI:10.1016/bs.ctdb.2018.12.002", "DOI:10.1016/j.devcel.2020.09.024", "DOI:10.1242/dmm.046920" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000223 ; owl:annotatedTarget """Lung neuroendocrine cells, also commonly known as pulmonary neuroendocrine cells (PNECs), are predominantly located in the respiratory epithelium of the bronchial and bronchiolar airways in the lungs. These cells, characterised by their small size and granular appearance, have a distinctive morphology that sets them apart from other lung cells. They are considered part of the diffuse neuroendocrine system due to their scattered distribution through the epithelium and have been classified into solitary cells and clustered forms known as neuroepithelial bodies. The primary function of PNECs is linked to regulation and maintenance of the lung environment. They are sensory in nature and can secrete various bioactive substances such as serotonin, calcitonin, calcitonin gene-related peptides, and bombesin-like peptides which modulate airway smooth muscle tone and influence gut motility. For example, they act as oxygen sensors in response to hypoxia and are responsible for releasing neuropeptides that can induce responses. Moreover, PNECs provide an afferent function as they are equipped with long microvilli that project into the lumen of the bronchus and react to changes in the chemical composition of the luminal content. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "PMID:15018448" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000223 ; owl:annotatedTarget "lung neuroendocrine cell" . [] oboInOwl:hasDbXref "PMID:33355253" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1000223 ; owl:annotatedTarget "PNEC" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_1000223 ; owl:annotatedTarget "The marker set CHGA, GRP can identify the Human cell type pulmonary neuroendocrine cell in the lung with a confidence of 0.94 (NS-Forest FBeta value)." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000239 ; owl:annotatedTarget "ZFA:0009143" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "pulmonary neuroendocrine cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000223 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000223" . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000236 ; owl:annotatedTarget "Any glial cell that is part of some posterior lateral line nerve." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000239 ; owl:annotatedTarget "Any glial cell that is part of some anterior lateral line nerve." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000245 ; owl:annotatedTarget "Any peripheral nervous system neuron that has its soma located in some posterior lateral line ganglion." . [] oboInOwl:hasDbXref "PMID:27864314" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000271 ; owl:annotatedTarget "An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000272 ; owl:annotatedTarget "Any secretory cell that is part of some lung." . [] oboInOwl:hasDbXref "PMID:22918806" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000274 ; owl:annotatedTarget "An extraembryonic cell that is part of the trophectoderm, representing the first lineage to differentiate in the embryo. This cell is crucial for implantation into the uterine wall and differentiates into trophoblast cells, which contribute to placenta formation and facilitate maternal-fetal nutrient and signal exchange." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000275 ; owl:annotatedTarget obo:CL_0002504 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000275 ; owl:annotatedTarget "A smooth muscle cell that is part of the small intestine." . [] oboInOwl:hasDbXref "DOI:10.1007/978-981-13-5895-1_1", "DOI:10.1038/nrgastro.2012.168", "DOI:10.1038/s41575-020-0271-2", "DOI:10.1053/j.gastro.2016.02.030", "DOI:10.1111/j.1582-4934.2008.00352.x" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000275 ; owl:annotatedTarget """Smooth muscle cells of the small intestine form a key component of the enteric system which is imperative for gastrointestinal motility. These cells are a specialized subgroup of smooth muscle cells, specifically found in the layers of the small intestine. The small intestine represents a significant part of the digestive system and plays a crucial role in the absorption of nutrients into the bloodstream. Smooth muscle cells of the small intestine are predominantly responsible for creating the contractions and relaxations that constitute intestinal motility. They trigger these movements in a coordinated and rhythmic manner known as peristalsis and segmentation. Peristalsis is a form of longitudinal and sequential contraction that pushes food from the upper gastrointestinal tract to the lower parts. Segmentation works by squeezing the intestine randomly, thereby facilitating the mixing of food particles and increasing contact with absorptive surfaces. These two processes are critical for intestinal motility and an effective digestive process. Apart from facilitating transit of food through contractions, these smooth muscle cells play a role in controlling the diameter of the vessels and the blood flow in the small intestine by their constrictive ability. These smooth muscle cells also contribute to the structural integrity of the small intestine by forming a part of its muscularis externa and muscularis mucosae. Additionally, they interact with other cell types such as enteric neurons and interstitial cells of Cajal (ICC), forming an integrated cellular network that ensures optimal functioning of the intestinal tract. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "FMA:15050" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000275 ; owl:annotatedTarget "non-striated muscle fiber of small intestine" . [] a owl:Axiom ; rdfs:label "smooth muscle cell of small intestine on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000275 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000275" . [] dc:license "http://creativecommons.org/licenses/by/4.0/" ; oboInOwl:hasDbXref "doi:10.1186/s13619-020-00061-5" ; a owl:Axiom ; rdfs:comment """Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer). ISC: Intestinal Stem Cell TA: Transit Amplifying Cells""" ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000275 ; owl:annotatedTarget . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000276 ; owl:annotatedTarget obo:CL_1000275 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000276 ; owl:annotatedTarget "A smooth muscle cell that is part of the duodenum." . [] oboInOwl:hasDbXref "PMID:30422572", "Wikipedia:Epithelium", "Wikipedia:Stratified_squamous_epithelium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000240 ; owl:annotatedTarget "A stratified epithelial cell that is part of squamous epithelium, characterized by multiple layers of cells. The basal layer is directly attached to the basement membrane and the apical layer consists of flattened squamous cells. This provides a protective barrier, commonly found in areas subject to abrasion, such as the skin, oral cavity, and esophagus." . [] oboInOwl:hasDbXref "FMA:15058" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000276 ; owl:annotatedTarget "non-striated muscle fiber of duodenum" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000277 ; owl:annotatedTarget obo:CL_1000275 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000277 ; owl:annotatedTarget "A smooth muscle cell that is part of the jejunum." . [] oboInOwl:hasDbXref "FMA:15062" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000277 ; owl:annotatedTarget "non-striated muscle fiber of jejunum" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000240 ; owl:annotatedTarget "ZFA:0009144" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000278 ; owl:annotatedTarget obo:CL_1000275 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000278 ; owl:annotatedTarget "A smooth muscle cell that is part of the ileum." . [] oboInOwl:hasDbXref "DOI:10.1152/advan.00025.2003", "https://www.ncbi.nlm.nih.gov/books/NBK532857/", "https://www.ncbi.nlm.nih.gov/books/NBK556137/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000278 ; owl:annotatedTarget """The smooth muscle fiber of the ileum primarily refers to a specific class of muscle cells present in the ileum, the final segment of the small intestine. Distinguished from skeletal muscle and cardiac muscle, smooth muscle does not possess striations and is under the control of the involuntary nervous system. These cells primarily facilitate the movement of digested food, a process known as peristalsis. These cells coordinate rhythmic contractions and relaxations, propelling the chyme toward the colon. This process is vital for efficient nutrient absorption in the small intestine and the transfer of undigested material to the large intestine. Moreover, the smooth muscle fibers enhance the ileum's ability to expand and adapt to volume changes without elevating internal pressure, known as compliance. The smooth muscle fiber of the ileum contributes to reflex responses, enhancing muscle contractions to propel intestinal contents in different physiological conditions. This involves intricate molecular signaling with neurotransmitters, hormones, and local signals. Thus, beyond its structural role, the smooth muscle fiber is crucial for the physiological functions of digestion and absorption in the small intestine. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "FMA:15066" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000278 ; owl:annotatedTarget "non-striated muscle fiber of ileum" . [] a owl:Axiom ; rdfs:label "smooth muscle fiber of ileum on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000278 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000278" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000279 ; owl:annotatedTarget obo:CL_0002504 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000279 ; owl:annotatedTarget "A smooth muscle cell that is part of the large intestine." . [] oboInOwl:hasDbXref "FMA:15653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000279 ; owl:annotatedTarget "non-striated muscle fiber of large intestine" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000029 ; owl:annotatedTarget obo:CL_0000540 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000280 ; owl:annotatedTarget "A smooth muscle cell that is part of the colon." . [] oboInOwl:hasDbXref "FMA:15663" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000280 ; owl:annotatedTarget "non-striated muscle fiber of colon" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000281 ; owl:annotatedTarget "A smooth muscle cell that is part of the cecum." . [] oboInOwl:hasDbXref "FMA:15681" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000281 ; owl:annotatedTarget "non-striated muscle fiber of cecum" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000282 ; owl:annotatedTarget obo:CL_1000280 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000282 ; owl:annotatedTarget "A smooth muscle cell that is part of the ascending colon." . [] oboInOwl:hasDbXref "FMA:17518" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000282 ; owl:annotatedTarget "non-striated muscle fiber of ascending colon" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000283 ; owl:annotatedTarget obo:CL_1000280 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000283 ; owl:annotatedTarget "A smooth muscle cell that is part of the transverse colon." . [] oboInOwl:hasDbXref "FMA:17519" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000283 ; owl:annotatedTarget "non-striated muscle fiber of transverse colon" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000284 ; owl:annotatedTarget obo:CL_1000280 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000284 ; owl:annotatedTarget "A smooth muscle cell that is part of the descending colon." . [] oboInOwl:hasDbXref "FMA:17520" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000284 ; owl:annotatedTarget "non-striated muscle fiber of descending colon" . [] oboInOwl:hasDbXref "PMID:30422572", "Wikipedia:Stratified_cuboidal_epithelium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000241 ; owl:annotatedTarget "A stratified epithelial cell that is part of cuboidal epithelium, characterized by multiple layers of cuboidal cells forming the apical layer. This provides a protective lining for ducts in large glands, such as sweat glands." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000285 ; owl:annotatedTarget obo:CL_1000280 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000285 ; owl:annotatedTarget "A smooth muscle cell that is part of the sigmoid colon." . [] oboInOwl:hasDbXref "FMA:17521" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000285 ; owl:annotatedTarget "non-striated muscle fiber of sigmoid colon" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000241 ; owl:annotatedTarget "ZFA:0009145" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000286 ; owl:annotatedTarget "A smooth muscle cell that is part of the rectum." . [] oboInOwl:hasDbXref "FMA:17522" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000286 ; owl:annotatedTarget "non-striated muscle fiber of rectum" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000287 ; owl:annotatedTarget "A muscle cell that is part of the anterior internodal tract." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000288 ; owl:annotatedTarget "A muscle cell that is part of the atrial branch of anterior internodal tract." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000289 ; owl:annotatedTarget "A muscle cell that is part of the atrial septal branch of anterior internodal tract." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000290 ; owl:annotatedTarget "A muscle cell that is part of the middle internodal tract." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000291 ; owl:annotatedTarget "A muscle cell that is part of the posterior internodal tract." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM889.CJPK.447" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000241 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000296 ; owl:annotatedTarget "An epithelial cell that is part of the urethra." . [] oboInOwl:hasDbXref "DOI:10.1016/j.celrep.2018.11.086", "DOI:10.1038/s41385-022-00565-0", "DOI:10.1089/ten.teb.2016.0352", "DOI:10.1101/2020.02.19.937615v2.full", "DOI:10.1152/ajprenal.00327.2009" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000296 ; owl:annotatedTarget """Epithelial cells of the urethra constitute the inner lining of the urethra, forming a mucosal barrier that helps protect the body from external contaminants. The type of epithelial cells found in the urethra can vary along its length. In general, the urethra is lined with stratified squamous epithelium in its distal or external portion, which is closer to the external environment. This type of epithelium provides protection against mechanical stress and pathogens. Closer to the bladder, the urethra transitions to a different type of epithelium. In males, the proximal part of the urethra is lined with pseudostratified columnar epithelium in the region where it passes through the prostate gland. In females, the transitional epithelium may be present in the proximal part of the urethra near the bladder. Epithelial cells of the urethra are primarily dedicated to the protection of underlying tissues from mechanical stress and pathogens during micturition (urination). They do this by creating a tight, impermeable barrier that prevents the entry and colonization of invading microbes. They produce a variety of antimicrobials and are tightly packed to prevent infiltration between cells, forming an integral part of the body's innate immune system. In addition to their protective role, these cells are involved in the secretion of mucus. This mucus acts as a lubricant that ensures the smooth and easy passage of urine from the bladder through the urethra and out of the body, reducing any potential damage from the erosive action of urine. Epithelial cells of the urethra are dynamic, constantly renewing their numbers to replace any cells lost through wear and tear. Any disruptions to the function or integrity of these cells may contribute to urinary tract infections and other urological disorders. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "epithelial cell of urethra on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000296 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000296" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000298 ; owl:annotatedTarget "A mesothelial cell that is part of the dura mater." . [] oboInOwl:hasDbXref "FMA:256516" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000298 ; owl:annotatedTarget "squamous mesothelial cell of dura mater" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000299 ; owl:annotatedTarget "A fibroblast that is part of the connective tissue of prostate." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM347.TXWZ.899" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000299 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000300 ; owl:annotatedTarget "A fibroblast that is part of the outer membrane of prostatic capsule." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000301 ; owl:annotatedTarget "A fibroblast that is part of the subepithelial connective tissue of prostatic gland." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM347.TXWZ.899" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000301 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000302 ; owl:annotatedTarget obo:CL_0002551 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000302 ; owl:annotatedTarget "A fibroblast that is part of the papillary layer of dermis." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000303 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "MESH:D018862", "PMID:19834574", "PMID:2274847", "PMID:24862916", "PMID:30415995", "Wikipedia:Merkel_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000242 ; owl:annotatedTarget "A specialized epithelial cell located in the skin epidermis and certain mucosal epithelia. It functions as a mechanoreceptor for light touch by forming synapse-like contacts with somatosensory afferent nerve endings, contributing to slowly adapting type I (SAI) tactile responses. Characterized by dense-core neuroendocrine granules, the Merkel cell exhibits both sensory and neuroendocrine properties, including regulated neurotransmitter release via SNARE complex-dependent mechanisms. Its development in mice depends on the transcription factor Atoh1." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000303 ; owl:annotatedTarget "A fibroblast that is part of the areolar connective tissue." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000304 ; owl:annotatedTarget "A fibroblast that is part of the connective tissue of nonglandular part of prostate." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000305 ; owl:annotatedTarget "A fibroblast that is part of the connective tissue of glandular part of prostate." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000306 ; owl:annotatedTarget "A fibroblast that is part of the tunica adventitia of artery." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000029 ; owl:annotatedTarget "Any neuron that develops from some migratory neural crest cell." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000242 ; owl:annotatedTarget "ZFA:0009146" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000307 ; owl:annotatedTarget "A fibroblast that is part of the dense regular elastic tissue." . [] oboInOwl:hasDbXref "PMID:24862916" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000242 ; owl:annotatedTarget "MC" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000308 ; owl:annotatedTarget obo:CL_0000135 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000308 ; owl:annotatedTarget "A fibrocyte that is part of the adventitia of ureter." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000309 ; owl:annotatedTarget "An adipocyte that is part of the epicardial fat." . [] oboInOwl:hasDbXref "FMA:261293" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000309 ; owl:annotatedTarget "adipocyte of epicardial fat" . [] oboInOwl:hasDbXref "FMA:261293" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000309 ; owl:annotatedTarget "epicardial fat cell" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM642.BMZS.772" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000242 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-epidermal-ridge/v1.2/assets/2d-ftu-skin-epidermal-ridge.png" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000310 ; owl:annotatedTarget "An adipocyte that is part of the epicardial fat of right ventricle." . [] oboInOwl:hasDbXref "FMA:261297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000310 ; owl:annotatedTarget "epicardial adipocyte of right ventricle" . [] oboInOwl:hasDbXref "FMA:261297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000310 ; owl:annotatedTarget "epicardial fat cell of right ventricle" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000311 ; owl:annotatedTarget "An adipocyte that is part of the epicardial fat of left ventricle." . [] oboInOwl:hasDbXref "MESH:D009457" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000243 ; owl:annotatedTarget "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear." . [] oboInOwl:hasDbXref "FMA:261300" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000311 ; owl:annotatedTarget "epicardial adipocyte of left ventricle" . [] oboInOwl:hasDbXref "FMA:261300" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000311 ; owl:annotatedTarget "epicardial fat cell of left ventricle" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000312 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of bronchus." . [] oboInOwl:hasDbXref "DOI:10.1016/S0165-6147(00)01600-X", "DOI:10.1016/S1357-2725(02)00083-3", "DOI:10.1080/07853890600585795", "DOI:10.2147/COPD.S38938" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000312 ; owl:annotatedTarget """Bronchial goblet cells are a subset of goblet cells that are predominantly found in the respiratory tract, specifically within the bronchi and bronchioles. Named for their flask-like shape and their apparent similarity to a goblet, these cells contribute significantly to the maintenance of lung health and homeostasis. In humans, goblet cells comprise up to 25% of the bronchial epithelial columnar cells and are an integral part of the mucus-secreting system of the respiratory tract and are primarily responsible for the production and secretion of mucus. The mucus secreted by bronchial goblet cells serves as a protective layer over the delicate and sensitive structures of the bronchi. The mucus, an amalgamation of glycoproteins, lipids, and other substances, traps any inhaled dust, microorganisms, and pollutants, preventing them from reaching deeper lung tissues and causing potential damage. Additionally, the mucus secretion aids in moistening the airway surface, thereby facilitating effective gas exchange and maintaining the overall health of the respiratory tract. Bronchial goblet cells have an innate defense mechanism wherein they increase secretion of mucus in response to irritants, infection or inflammation in the airway. This strategy, however, if incessantly stimulated, can lead to airway obstruction and health complications like asthma and chronic obstructive pulmonary disease (COPD). (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "FMA:263032" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000312 ; owl:annotatedTarget "goblet cell of epithelium of bronchus" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000244 ; owl:annotatedTarget "A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_1000312 ; owl:annotatedTarget "The marker set PLCG2, ANKRD36C can identify the Human cell type bronchial goblet cell in the lung with a confidence of 0.55 (NS-Forest FBeta value)." . [] a owl:Axiom ; rdfs:label "bronchial goblet cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000312 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000312" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000313 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of stomach." . [] oboInOwl:hasDbXref "FMA:263035" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000313 ; owl:annotatedTarget "goblet cell of epithelium of stomach" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000244 ; owl:annotatedTarget "ZFA:0009148" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000314 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of gastric cardiac gland." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000245 ; owl:annotatedTarget "Obsolete. Use PO:0000353 from Plant Ontology instead. Cell in exodermis or endodermis that remains thin walled when the associated cells develop thick secondary walls. Has casparian strip in endodermis." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000315 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of principal gastric gland." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000316 ; owl:annotatedTarget "OBSOLETE: A goblet cell that is part of the epithelium of small intestine." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000246 ; owl:annotatedTarget "ZFA:0009149" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000317 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of intestinal villus." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000318 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of crypt of lieberkuhn of small intestine." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000319 ; owl:annotatedTarget "OBSOLETE: A goblet cell that is part of the epithelium proper of small intestine." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000320 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of large intestine." . [] oboInOwl:hasDbXref "DOI:10.1038/mi.2015.32", "DOI:10.1042/BSR20201471", "DOI:10.1111/imr.12182", "DOI:10.1146/annurev-physiol-021115-105447", "DOI:full/10.1111/febs.15731" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000320 ; owl:annotatedTarget """The large intestine goblet cell is a highly specialized type of mucosal epithelial cell that is located within the epithelial lining of the large intestine. The key function of goblet cells is the production and secretion of a protective layer of mucus which is essential for maintaining gut homeostasis. Goblet cells have a characteristic 'goblet-like' shape, which adapts them for this specific function: organelles such as the nucleus, mitochondria, ER, and Golgi apparatus are located in the basal portion of the cell; while the vesicles with mucins (required for mucus production) are located apically, close to the apical membrane where their exocytosis takes place. The goblet cells of the large intestine produce a thick layer of mucus that coats the intestinal lumen. This mucus provides a barrier that prevents the direct contact of intestinal cells with bacteria and other potentially toxic substances present in the digestive tract. It also lubricates the intestine to facilitate the smooth passage of digested food material. It is worth noting that the mucus system differs between the small and large intestine: although in both the mucus is built around MUC2 mucin polymers produced by goblet cells, it is becoming clear that there are several types of goblet cells that function in different ways. From an immunological perspective, large intestine goblet cells participate in promoting a balanced gut immune response. They contribute to the process known as immune tolerance, where they prevent the body's immune system from overreacting to the trillions of bacteria present in the gut. These cells achieve this by secreting molecules that help maintain a calm environment, limiting inflammatory reactions unless absolutely necessary. Any dysfunction or decrease in the number of goblet cells can result in a compromised intestinal barrier leading to various health issues, including inflammatory bowel disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "large intestine goblet cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000320 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000320" . [] oboInOwl:hasDbXref "VHOG:0001484" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000247 ; owl:annotatedTarget "Type of neuron that is a primary mechanosensory cell, with peripheral neurites innervating the skin with free nerve endings." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000321 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of crypt of Lieberkuhn of large intestine." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM294.HJJZ.279" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000321 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/large-intestine-crypt-lieberkuhn/v1.2/assets/2d-ftu-large-intestine-crypt-lieberkuhn.png" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000247 ; owl:annotatedTarget "ZFA:0009150" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000322 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of pancreatic duct." . [] oboInOwl:hasDbXref "FMA:263058" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000322 ; owl:annotatedTarget "goblet cell of epithelium of pancreatic duct" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM586.MNXV.276" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000322 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-pancreatic-acinus/v1.2/assets/2d-ftu-pancreas-pancreatic-acinus.png" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000029 ; owl:annotatedTarget "ZFA:0009009" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "VHOG:0001484" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000247 ; owl:annotatedTarget "Rohon Beard cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000323 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of pyloric gland." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000324 ; owl:annotatedTarget "A goblet cell that is part of the epithelium proper of duodenum." . [] oboInOwl:hasDbXref "VHOG:0001484" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000247 ; owl:annotatedTarget "RB neuron" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM974.XQDB.889" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000324 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/small-intestine-villus/v1.0/assets/2d-ftu-small-intestine-villus.png" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000325 ; owl:annotatedTarget "A goblet cell that is part of the epithelium proper of jejunum." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000248 ; owl:annotatedTarget "Obsolete. Use PO:0020047 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000326 ; owl:annotatedTarget "A goblet cell that is part of the epithelium proper of ileum." . [] oboInOwl:hasDbXref "DOI:10.1007/s11894-010-0131-2", "DOI:10.1038/nature10863", "DOI:10.1038/s41575-022-00675-x", "DOI:10.1111/imr.12182" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000326 ; owl:annotatedTarget """The ileal goblet cell is a subset of intestinal goblet cells that are a key component of the epithelium of the ileum, a portion of the small intestine. Goblet cells are named and characterized by their distinctive 'goblet' shape with a narrow base tapering to a broad apical surface; located between the lumen of the intestine and the internal environment of the body, they serve an integral role in maintaining gut homeostasis. Like all intestinal goblet cells, the primary function of ileal goblet cells is the production and secretion of mucins, large, heavily glycosylated proteins that combine to form mucus. This mucus lining serves as a protective barrier, shielding the underlying tissue from the potentially damaging effects of digestive enzymes, acids, or pathogenic microbes present in the gut lumen. Their strategic location in the ileal segment of the intestinal tract aids in efficient nutrient absorption while also maintaining an impregnable barrier against potential pathogens, ensuring an intricate balance. Goblet cells of the ileum also play a significant role in immune modulation. They are thought to promote oral tolerance (the immune unresponsiveness to orally ingested antigens such as food) by delivering luminal antigens to underlying dendritic cells, thereby driving immune education and tolerogenic responses. They also secrete bioactive molecules, such as the trefoil factor peptide TFF3, which aids in repairing damaged epithelium. By performing these crucial functions, ileal goblet cells not only aid in maintaining intestinal health, but also contribute significantly to the overall well-being of the organism. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "ileal goblet cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000326 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000326" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000327 ; owl:annotatedTarget "A goblet cell that is part of the epithelium proper of appendix." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000249 ; owl:annotatedTarget "ZFA:0009151" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000328 ; owl:annotatedTarget "OBSOLETE: A goblet cell that is part of the epithelium proper of large intestine." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000329 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of trachea." . [] oboInOwl:hasDbXref "DOI:10.1016/S1357-2725(02)00083-3", "DOI:10.1164/ajrccm.154.6.8970383", "DOI:10.1165/ajrcmb.25.5.f218", "DOI:10.2147/COPD.S38938", "DOI:10.3109/01902148.2013.791733" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000329 ; owl:annotatedTarget """Tracheal goblet cells are specialized cells found in the lining of the trachea. They are a key component of the tracheobronchial epithelium, a critical region responsible for maintaining open airways and preventing the ingress of harmful particles or irritants. Goblet cells are filled with membrane-bound secretory granules, which are responsible for their distinctive, goblet-like shape. Goblet cells specialize in the production and secretion of mucus, a slimy substance composed primarily of glycoproteins (mucins) and water. This sticky mucus serves to trap foreign particles and pollutants, such as dust, bacteria, and viruses that an organism breathes in. After trapping these particles, the cilia on neighboring ciliated epithelial cells beat synchronously, forming a coordinated escalator to push mucus upwards toward the pharynx, where it's either swallowed or expectorated. This system, known as the mucociliary clearance or escalator, forms a crucial barrier in the lungs against respiratory pathogens and external insults. Changes in the number or function of tracheal goblet cells can engender health complications. For example, goblet cell hyperplasia, or excessive growth of goblet cells, is a common feature of chronic inflammatory lung diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD). This condition results in mucus hypersecretion, airway blockage, and increased risk of respiratory tract infections. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "FMA:263075" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000329 ; owl:annotatedTarget "goblet cell of epithelium of trachea" . [] a owl:Axiom ; rdfs:label "tracheal goblet cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000329 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000329" . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000250 ; owl:annotatedTarget "Obsolete. Use PO:0020019 from Plant Ontology instead. A haploid (1n) spore developing into a female gametophyte in heterosporous plants." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000330 ; owl:annotatedTarget "A serous secreting cell that is part of the epithelium of trachea." . [] oboInOwl:hasDbXref "DOI:10.1002/dvdy.24250", "DOI:10.1016/B978-012330215-1/50029-6", "DOI:10.1016/S0034-5687(01)00214-", "DOI:10.1074/jbc.M208826200" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000330 ; owl:annotatedTarget """Serous cells are specialized epithelial cells and can be found lining the trachea and brochus. They are among the major components of the respiratory epithelium. These cells are known for their production and release of serous secretions, which form a key component of airway mucus. These secretions primarily comprise of water, proteins, and enzymes, such as lysozyme and peroxidases. Their main purposes are to provide hydration and lubrication to the airway tissue and to act as a defense mechanism against pathogens. While the lysozyme and peroxidases contribute to the destruction of bacteria, the water in the secretions helps to liquefy the mucus, facilitating the effective functioning of the ciliated cells that propel the mucus up the trachea. The coordinated action between serous cells and other cell types in the tracheal epithelium proves essential for maintaining a healthy respiratory tract. Dysfunction or damage of these cells can lead to various respiratory tract disorders, such as cystic fibrosis and asthma. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "serous cell of epithelium of trachea on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000330 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000330" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000251 ; owl:annotatedTarget "ZFA:0009152" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000331 ; owl:annotatedTarget "A serous secreting cell that is part of the epithelium of bronchus." . [] oboInOwl:hasDbXref "DOI:10.1152/physrev.00039.2014", "https://www.ncbi.nlm.nih.gov/books/NBK534789/", "https://www.sciencedirect.com/topics/neuroscience/secretory-cell" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000331 ; owl:annotatedTarget """Serous cells of the epithelium of the bronchus, also termed bronchial serous cells, are predominantly found within the seromucous glands located in the bronchial submucosa. Serous cells can also be found in the trachea and are characterized by small, sparse, electron-dense granules. Serous cells are specialized cells responsible for the production and secretion of serous fluid. Serous fluid, mainly composed of water, proteins, and various types of salts, provides many benefits: it helps moisturize the airways, keep the bronchial tube walls moist, and safeguard the bronchial tubes against various foreign particles and infectious agents such as bacteria and viruses. Moreover, the fluid released by these cells assists in the lubrication and reduced friction in the bronchi, allowing for smoother airflow. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "serous cell of epithelium of bronchus on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000331 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000331" . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000252 ; owl:annotatedTarget "Obsolete. Use PO:0020048 from Plant Ontology instead. A haploid (1n) spore developing into a male gametophyte in heterosporous plants; the uninucleate pollen grain in seed plants." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000332 ; owl:annotatedTarget "A serous secreting cell that is part of the epithelium of terminal bronchiole." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000333 ; owl:annotatedTarget "A serous secreting cell that is part of the epithelium of bronchiole." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000253 ; owl:annotatedTarget "ZFA:0009153" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000334 ; owl:annotatedTarget obo:CL_0000584 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000334 ; owl:annotatedTarget "An enterocyte that is part of the epithelium of small intestine." . [] oboInOwl:hasDbXref "DOI:10.1038/nrgastro.2013.35", "DOI:10.1038/nri3738", "DOI:10.1084/jem.20191130", "DOI:10.3389/fphys.2021.699152/full" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000334 ; owl:annotatedTarget """Enterocytes of the epithelium of the small intestine are specialized cells that reside in the lining of the small intestine, and are primarily responsible for the essential process of nutrient absorption. These cells are columnar epithelial cells with an apical surface lined with microvilli, a feature referred to as the 'brush border', to maximize the surface area available for absorption. Enterocytes play a critical role in both the digestion and absorption of nutrients from food. Their extensive brush border contains enzymes that further assist in nutrient breakdown and transport proteins that transfer nutrients, such as glucose, amino acids, lipids, and vitamins, across the cell membrane. The enterocytes of the small intestine also participate in the barrier function of the gut lining. Enterocytes are connected by tight junctions, which act as a primary defense line against pathogenic invasion by maintaining intestinal barrier integrity. Additionally, their cell surface is coated in glycocalyx and mucus which forms a defensive barrier preventing the penetration of harmful bacteria into the systemic circulation. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "enterocyte of epithelium of small intestine on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000334 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000334" . [] dc:license "http://creativecommons.org/licenses/by/4.0/" ; oboInOwl:hasDbXref "doi:10.1186/s13619-020-00061-5" ; a owl:Axiom ; rdfs:comment """Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer). ISC: Intestinal Stem Cell TA: Transit Amplifying Cells""" ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000334 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "TAIR:lr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000254 ; owl:annotatedTarget "Obsolete. Use PO:0020094 from Plant Ontology instead. The female gamete of plants." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000335 ; owl:annotatedTarget "An enterocyte that is part of the epithelium of intestinal villus." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000337 ; owl:annotatedTarget "An enterocyte that is part of the epithelium of duodenal gland." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000338 ; owl:annotatedTarget "An enterocyte that is part of the epithelium of crypt of Lieberkuhn of small intestine." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000339 ; owl:annotatedTarget "An enterocyte that is part of the epithelium proper of small intestine." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000340 ; owl:annotatedTarget "An enterocyte that is part of the epithelium proper of duodenum." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000341 ; owl:annotatedTarget "An enterocyte that is part of the epithelium proper of jejunum." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000342 ; owl:annotatedTarget "An enterocyte that is part of the epithelium proper of ileum." . [] oboInOwl:hasDbXref "DOI:10.1038/nri3738", "DOI:10.1084/jem.20191130", "DOI:10.1111/j.1365-2249.2011.04523.x" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000342 ; owl:annotatedTarget """Enterocytes of the epithelium proper of the ileum, commonly known as ileal enterocytes, are specialized epithelial cells found lining the inner surface of the ileum, the final section of the small intestine in the human body. They play a pivotal role in nutrient absorption, digestive metabolic functions, and the maintenance of the host’s immune response. Like enterocytes in other parts of the intestine, ileal enterocytes exhibit distinct characteristics specific to their function and role. They have microvilli on their apical surfaces to increase absorption and are important in the absorption of vitamins and the reabsorption of bile salts. These cells also produce enzymes that metabolize lipids and xenobiotics. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "enterocyte of epithelium proper of ileum on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000342 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000342" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000343 ; owl:annotatedTarget obo:CL_0000510 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000343 ; owl:annotatedTarget "A paneth cell that is part of the epithelium of small intestine." . [] oboInOwl:hasDbXref "DOI:10.1007/s00018-002-8412-z", "DOI:10.1038/nature09637", "DOI:10.1038/nrmicro2546", "DOI:10.1146/annurev-physiol-030212-183744", "DOI:10.3389/fimmu.2020.00587" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000343 ; owl:annotatedTarget """Paneth cells of the epithelium of the small intestine, often referred to simply as Paneth cells, are a type of specialized secretory cell that forms an integral part of the intestinal crypts of Lieberkühn – gland-like invaginations lining the small intestine. Named after the Austrian physician Josef Paneth, who first identified them in the late 19th century, these cells are significant because of their substantial involvement in the mucosal immune system and intestinal stem cell maintenance. Functionally, Paneth cells play a key role in maintaining gut homeostasis and in the first line of antimicrobial defense, mainly through the secretion of a range of antimicrobial peptides and proteins. These include lysozymes, cryptdins, or alpha-defensins, which have potent activity against various gut pathogens including bacteria, fungi, and parasites. Furthermore, Paneth cells of the small intestine are also known to release secretory phospholipase A2, an enzyme active against gram-positive bacteria. Additionally, they secrete several growth factors like EGF, TGF-alpha, and Wnt3, which are crucial for stem cell support and the overall maintenance of intestinal mucosal integrity. The unique location of Paneth cells at the base of the crypts positions them in very close proximity to intestinal stem cells. This not only facilitates their role in stem cell maintenance but also involves them in epithelial regeneration and repair following injury. Dysfunctional Paneth cells have been associated with several gut disorders, like Crohn’s disease and necrotizing enterocolitis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "paneth cell of epithelium of small intestine on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000343 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000343" . [] dc:license "http://creativecommons.org/licenses/by/4.0/" ; oboInOwl:hasDbXref "doi:10.1186/s13619-020-00061-5" ; a owl:Axiom ; rdfs:comment """Figure depicts a cross section of intestinal villi in the small intestine , including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer). ISC: Intestinal Stem Cell TA: Transit Amplifying Cells""" ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000343 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000344 ; owl:annotatedTarget "A Paneth cell that is part of the epithelium proper of small intestine." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000345 ; owl:annotatedTarget "A paneth cell that is part of the epithelium of crypt of Lieberkuhn of small intestine." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000346 ; owl:annotatedTarget "An enterocyte that is part of the epithelium proper of large intestine." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:16870803", "PMID:23821742", "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000347 ; owl:annotatedTarget "An enterocyte (absorptive epithelial cell) of the colonic epithelium, characterized by a columnar shape. This cell is responsible for the absorption, transport, and metabolization of short-chain fatty acids (SCFAs) produced by gut bacteria, as well as the transport and absorption of water and electrolytes." . [] oboInOwl:hasDbXref "DOI:10.1007/s11894-010-0130-3", "DOI:10.1038/nrgastro.2013.35", "DOI:10.1038/nri3738", "DOI:10.1084/jem.20191130", "DOI:10.3389/fimmu.2019.00277" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000347 ; owl:annotatedTarget """Enterocytes of the colon are specialized epithelial cells located in the lining of the colon, the largest part of the large intestine. These cells play a critical role in absorbing water, electrolytes, and certain vitamins from the food material passed on from the small intestine. With a unique structure of finger-like protrusions referred to as microvilli, the enterocytes increase their surface area for effective absorption. The colon is the last part of the digestive system, and as such, it is responsible for compacting undigested food materials and forming fecal matter. Enterocytes of the colon facilitate this process effectively through absorption of water. Enterocytes are known for their high regeneration potential, replenishing every 4-5 days, enabling the healthy functioning of the colon. They originate from stem cells located in the crypt of the colon and differentiate into mature enterocytes as they migrate upwards towards the luminal surface. This constant turnover aids in maintaining the intestinal barrier, preventing the entry of detrimental substances into the systemic circulation. Their tight junctions with other epithelial cells provide a robust barrier against invasive pathogens. Enterocytes of the colon are involved in the communication with the gut microbiota. These cells harbor enzymes necessary for the metabolism of short-chain fatty acids, which are the byproducts of the fermentation process by gut bacteria. Short-chain fatty acids serve as a major energy source for colonocytes and are important for maintaining colonic health. The dysfunction of enterocytes, therefore, could lead to disorders such as inflammatory bowel disease or colorectal cancer. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "colonocyte on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000347 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000347" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000348 ; owl:annotatedTarget obo:CL_0002633 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000348 ; owl:annotatedTarget "A basal cell that is part of the epithelium of trachea." . [] oboInOwl:hasDbXref "DOI:10.1164/rccm.201408-1492PP", "DOI:10.1165/rcmb.2021-0150ED", "DOI:10.1242/dmm.006031", "DOI:10.3389/falgy.2021.787128" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000348 ; owl:annotatedTarget """Basal cells of epithelium of trachea are a vital cell population within the respiratory tract's lining, specifically in the trachea's epithelium. These cells are located at the base of the columnar epithelial cell layer and can be identified by their characteristic cuboidal shape, a large nucleus and few organelles, as well as scattered microvilli. The basal cells are not in direct contact with the lumen, which is covered by a layer of ciliated and non-ciliated columnar cells. Instead, the basal cells are connected to, and line, a thin basement membrane. The primary function of basal cells involves stem cell activity and epithelial tissue maintenance. Basal cells in the trachea play a crucial role in the regeneration and repair of the tracheal epithelium during damage or injury, acting as progenitor cells for ciliated and secretory cells. They serve as a reserve pool of cells, ready to proliferate and differentiate as needed for homeostatic tissue maintenance or in repair processes when the epithelium has been compromised, whether by injury or disease. These cells are also implicated in numerous disease pathways. Conditions like chronic obstructive pulmonary disease and lung cancer exhibit unusual behavior and quantities of tracheal basal cells, making these cells a focal point in respiratory disease research. In summary, basal cells in the tracheal epithelium have a multifaceted role in maintaining, repairing, and influencing tracheal health, playing a crucial role in the stability of the respiratory system. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "basal cell of epithelium of trachea on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000348 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000348" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000349 ; owl:annotatedTarget "A basal cell found in the bronchus epithelium." . [] oboInOwl:hasDbXref "DOI:10.1002/ar.1092380310", "DOI:10.1038/labinvest.2015.114", "DOI:10.1136/thx.2004.la0104", "DOI:10.3389/falgy.2021.787128" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000349 ; owl:annotatedTarget """The basal cells of the epithelium of the bronchus are a vital component of the cellular linings found within the bronchial tubes of the respiratory system. They are typically nonciliated, cuboidal cells that are tightly attached to the basement membrane, thereby providing structural support for the epithelial tissues. The function of the basal cell of the bronchial epithelium is multifaceted, underscoring the importance of these cells for respiratory health. One of their primary roles involves regeneration and cellular turnover. They serve as local stem cells, being able to proliferate and differentiate into other cell types such as ciliated and secretory epithelial cells. This regenerative function of basal cells is required for maintaining the integrity of the bronchial epithelium and is especially critical after injury or during disease states when there is an increased need for new cells to repair damaged tissue or replace lost cells. In addition to these regenerative duties, basal cells of the bronchial epithelium play a crucial role in providing a defensive barrier against inhaled substances. They participate in the coordinated immune response directed against airborne pathogens, foreign particles, and toxins that enter the respiratory tract. Basal cells can respond to inflammation or irritation by altering their activities, which include proliferating, differentiating, or producing bioactive substances. Throughout all these responses, the basal cells help to maintain the homeostasis of the bronchial tubes, allowing for the efficient transport of air to and from the lungs. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "basal cell of epithelium of bronchus on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000349 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000349" . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000255 ; owl:annotatedTarget "Any cell that in taxon some Eukaryota." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000350 ; owl:annotatedTarget obo:CL_0002633 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000350 ; owl:annotatedTarget "A basal cell that is part of the epithelium of terminal bronchiole." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000351 ; owl:annotatedTarget obo:CL_0002633 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000351 ; owl:annotatedTarget "A basal cell that is part of the epithelium of respiratory bronchiole." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000352 ; owl:annotatedTarget obo:CL_0002633 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000352 ; owl:annotatedTarget "A basal cell that is part of the epithelium of bronchiole." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000353 ; owl:annotatedTarget obo:CL_0000682 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000353 ; owl:annotatedTarget "A M cell that is part of the epithelium of small intestine." . [] oboInOwl:hasDbXref "DOI:10.1038/mi.2013.30", "DOI:10.1093/jb/mvv121", "DOI:10.1111/j.1574-695X.2007.00359.x", "DOI:10.3389/fimmu.2019.01499" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000353 ; owl:annotatedTarget """Microfold cells, also widely known as M cells, are a distinct type of epithelial cell found in the gut, including the small intestine, specifically within the Peyer’s patches, a component of the gut-associated lymphoid tissue (GALT). M cells play a crucial role in the immune response within the intestine environment. These cells are characterized by microfolds (short microvilli, which give them their name), a reduced, thin glycocalyx, and a deeply invaginated basolateral membrane next to immune cells such as B cells, T cells, and macrophages, and DCs. These features allow the M cells to form the first point of contact between the gut lumen and the intestinal immune system. They are well-regulated gateways that capture and transport antigens, such as bacteria, viruses, and other foreign substances found in the lumen, to the underlying cells of the immune system. This specialized transport mechanism, called ‘transcytosis’, involves engulfment of these antigens from the apical side, transport across their cytoplasm, and release on the basolateral side of the cells, where immune responses can be initiated. Furthermore, M cells have complex interactions with members of the gut microbiota and other immune cells, making them essential for maintaining gut homeostasis. This cross-talk shapes the diversity and makeup of the gut microbiota, subsequently having a substantial impact on the host's health. In certain situations, pathogenic organisms can exploit the transcytosis mechanism to infiltrate the host's system, causing various infectious diseases. The overarching significance of M cells in the small intestine lies in their role of surveillance and protection against a wide range of potentially harmful pathogens, while also facilitating beneficial interactions with commensal microbes. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "microfold cell of epithelium of small intestine on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000353 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000353" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000354 ; owl:annotatedTarget "A M cell that is part of the epithelium of intestinal villus." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000355 ; owl:annotatedTarget "A M cell that is part of the epithelium proper of small intestine." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000356 ; owl:annotatedTarget "A M cell that is part of the epithelium proper of duodenum." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000357 ; owl:annotatedTarget "A M cell that is part of the epithelium proper of jejunum." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000358 ; owl:annotatedTarget "A M cell that is part of the epithelium proper of ileum." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000359 ; owl:annotatedTarget "A M cell that is part of the epithelium proper of appendix." . [] oboInOwl:hasDbXref "PMID:37824650", "Wikipedia:Glioblast" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000030 ; owl:annotatedTarget "A non-terminally differentiated cell that develops form the neuroectoderm. Glioblast has the potential to differentiate into various types of glial cells, including astrocytes and oligodendrocytes." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000257 ; owl:annotatedTarget "Any cell that in taxon some Eumycetozoa." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000360 ; owl:annotatedTarget "A M cell that is part of the epithelium proper of large intestine." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000361 ; owl:annotatedTarget obo:CL_0002073 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000361 ; owl:annotatedTarget "A transitional myocyte that is part of the interatrial septum." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000258 ; owl:annotatedTarget "Obsolete. Use PO:0000355 from Plant Ontology instead. A fiber like tracheid in the secondary xylem; commonly thick walled, with pointed ends and bordered pits that have lenticular to slit like apertures." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000362 ; owl:annotatedTarget obo:CL_0002073 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000362 ; owl:annotatedTarget "A transitional myocyte that is part of the interventricular septum." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000363 ; owl:annotatedTarget "A transitional myocyte that is part of the atrial branch of anterior internodal tract." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000364 ; owl:annotatedTarget "A transitional myocyte that is part of the anterior internodal tract." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000365 ; owl:annotatedTarget "A transitional myocyte that is part of the atrial septal branch of anterior internodal tract." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000366 ; owl:annotatedTarget "A transitional myocyte that is part of the middle internodal tract." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000367 ; owl:annotatedTarget "A transitional myocyte that is part of the posterior internodal tract." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000260 ; owl:annotatedTarget "Obsolete. Use PO:0000373 from Plant Ontology instead. Cell containing mucilages or gums or similar carbohydrate material characterized by the property of swelling in water." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000368 ; owl:annotatedTarget "A transitional myocyte that is part of the anterior division of left branch of atrioventricular bundle." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000369 ; owl:annotatedTarget "A transitional myocyte that is part of the septal division of left branch of atrioventricular bundle." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000370 ; owl:annotatedTarget "A transitional myocyte that is part of the left branch of atrioventricular bundle." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000262 ; owl:annotatedTarget "Obsolete. Use PO:0000351 from Plant Ontology instead. An epidermal cell that divides to produce the guard cells." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000371 ; owl:annotatedTarget "A transitional myocyte that is part of the right branch of atrioventricular bundle." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000372 ; owl:annotatedTarget "A transitional myocyte that is part of the atrial part of atrioventricular bundle." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000373 ; owl:annotatedTarget "A transitional myocyte that is part of the ventricular part of atrioventricular bundle." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000374 ; owl:annotatedTarget "A transitional myocyte that is part of the posterior division of left branch of atrioventricular bundle." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000375 ; owl:annotatedTarget "A myocardial endocrine cell that is part of the septal division of left branch of atrioventricular bundle." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000264 ; owl:annotatedTarget "Obsolete. Use PO:0000400 from Plant Ontology instead. A cambial cell on the phloem side of the cambial zone that is the source of one or more cells arising by periclinal divisions and differentiating into phloem elements with or without additional divisions in various planes." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000376 ; owl:annotatedTarget obo:CL_0002068 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000376 ; owl:annotatedTarget "A Purkinje myocyte that is part of the interventricular septum." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000266 ; owl:annotatedTarget "Obsolete. Use PO:0004011 from Plant Ontology instead. A cell constituting an active locus of meristematic activity in a tissue composed of somewhat older, differentiating cells." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000377 ; owl:annotatedTarget obo:CL_0000307 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000377 ; owl:annotatedTarget obo:CL_0002066 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000377 ; owl:annotatedTarget "A Feyrter cell that is part of the epithelium of trachea." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000378 ; owl:annotatedTarget "A type I vestibular sensory cell that is part of the stato-acoustic epithelium." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000268 ; owl:annotatedTarget "Obsolete. Consult Plant Ontology instead. The cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. Classified into sieve cell and sieve tube member." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000379 ; owl:annotatedTarget "A type I vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth." . [] oboInOwl:hasDbXref "ISBN:047124520" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000270 ; owl:annotatedTarget "Obsolete. Use PO:0000284 from Plant Ontology instead. An epidermal cell associated with a stoma and at least morphologically distinguishable from the epidermal cells composing the groundmass of the tissue." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000380 ; owl:annotatedTarget "A type I vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000381 ; owl:annotatedTarget "A type I vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000272 ; owl:annotatedTarget "OBSOLETE, use term from Plant Ontology. A cell localized in the vascular cambium or phellogen. Its periclinal division can contribute cells either to the outside or to the inside of the axis; in vascular cambium, classified into fusiform initials (source of axial cells of xylem and phloem) and ray initials (source of the ray cells)." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000382 ; owl:annotatedTarget "A type II vestibular sensory cell that is part of the stato-acoustic epithelium." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000276 ; owl:annotatedTarget "Obsolete. Use PO:0000077 from Plant Ontology instead. Cell variable in form and size, being more or less thick, often lignified, secondary walls. Belongs to the category of subcells and may or may not be devoid of protoplast at maturity." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000383 ; owl:annotatedTarget "A type II vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000384 ; owl:annotatedTarget "A type II vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000030 ; owl:annotatedTarget "ZFA:0009010" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "DictyBase:DDB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000277 ; owl:annotatedTarget "OBSOLETE: Initial population of prestalk cells that activate the ecmA promoter at the mound stage and that presumably further differentiate into pstA and pstO cells." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000385 ; owl:annotatedTarget "A type II vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000391 ; owl:annotatedTarget obo:CL_0000148 . [] oboInOwl:hasDbXref "TAIR:lr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000278 ; owl:annotatedTarget "Obsolete. Use PO:0020090 from Plant Ontology instead. OBSOLETED, use term from Plant Ontology. A cell containing the two polar nuclei which, after double fertilization, will develop into the endosperm." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000391 ; owl:annotatedTarget "A melanocyte that is part of the eyelid." . [] oboInOwl:hasDbXref "FMA:59175" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000391 ; owl:annotatedTarget "eyelid melanocyte" . [] oboInOwl:hasDbXref "FMA:59175" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000391 ; owl:annotatedTarget "sebaceous gland of wolff" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000394 ; owl:annotatedTarget "A myoepithelial cell that is part of the intralobular part of terminal lactiferous duct." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000397 ; owl:annotatedTarget "An endothelial cell that is part of the venous sinus of red pulp of spleen." . [] oboInOwl:hasDbXref "TAIR:lr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000280 ; owl:annotatedTarget "Obsolete. Use PO:0020097 from Plant Ontology instead. The cell that will give rise to the generative nuclei which will participate in fertilization." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:3926620" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000398 ; owl:annotatedTarget "An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates." . [] oboInOwl:hasDbXref "DOI:10.1016/j.jhep.2016.07.009", "DOI:10.1038/cmi.2016.5", "DOI:10.1038/s41575-018-0020-y", "DOI:10.1038/s41575-020-00411-3", "https://www.sciencedirect.com/topics/immunology-and-microbiology/disse-space" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000398 ; owl:annotatedTarget """Endothelial cells of hepatic sinusoids, also known as hepatic or liver sinusoidal endothelial cells (HSEC or LSEC), are unique, specialized type of endothelial cells located in the liver. They are the building units of the hepatic sinusoid, which functions as a specialized capillary system that facilitates the exchange of various substances between the blood and hepatocytes. This finely tuned environment, facilitated by HSEC, is primordial for the liver's multiple physiologic functions that include nutrient metabolism, toxin inactivation, and immunomodulation. The HSEC have a distinctive morphology that sets them apart from the typical endothelial cells found in other organs. These cells are exceptionally thin to allow for efficient transfer of molecules and characterized by fenestrations, which are non-diaphragmatic, sieve-like openings that provide an open filtration pathway from the sinusoidal lumen to the space of Disse, where hepatocytes are exposed. The fenestration is a crucial feature that allows lipoproteins, nutrients, and other plasma components easy access to hepatocytes for essential liver functions, including clearance of waste products and metabolic regulation. HSECs further play a vital role in immune functionality in the liver. They act as a sentinel, determining the nature of the immune response to encountered particulates. They possess a capacity for antigen presentation and express a series of immune-related surface molecules, which helps in immunosurveillance and immunoregulation. The HSEC also aid in the removal and destruction of virus-infected cells, harmful microorganisms, and circulatory waste products to safeguard liver health and general systemic cleanliness. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "PMID:30348985" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000398 ; owl:annotatedTarget "LSEC" . [] oboInOwl:hasDbXref "FMA:62911" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000398 ; owl:annotatedTarget "endotheliocyte of hepatic sinusoid" . [] oboInOwl:hasDbXref "PMID:30348985" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000398 ; owl:annotatedTarget "liver sinusoidal endothelial cell" . [] oboInOwl:hasDbXref "ISBN:0471245208", "PMID:10938806" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000282 ; owl:annotatedTarget "Obsolete. Use PO:0000282 from Plant Ontology instead. An outgrowth from the epidermis. Trichomes vary in size and complexity and include hairs, scales, and other structures and may be glandular. In Arabidopsis, patterning of trichome development is not random but does not appear to be lineage-based like stomata." . _:genid14930 a owl:Axiom, owl:Restriction ; rdfs:label "endothelial cell of hepatic sinusoid on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000398 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000398" ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_P11087 . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM889.CJPK.447" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000398 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" . _:genid14932 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:CL_0000066 _:genid14934 ) ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_P26618 . _:genid14934 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002292 ; owl:someValuesFrom obo:PR_P51885, obo:UBERON_0009697 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000405 ; owl:annotatedTarget "An epithelial cell that is part of the appendix." . [] oboInOwl:hasDbXref "FMA:63602" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000405 ; owl:annotatedTarget "columnar epitheliocyte of appendix" . [] oboInOwl:hasDbXref "FMA:63602" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000405 ; owl:annotatedTarget "epithelial cell of vermiform appendix" . [] oboInOwl:hasDbXref "ISBN:0879015322" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000284 ; owl:annotatedTarget "Obsolete. Use PO:0000071 from Plant Ontology instead. A specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." . [] oboInOwl:hasDbXref "FMA:67102", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000409 ; owl:annotatedTarget "A muscle cell that is part of the sinoatrial node." . [] oboInOwl:hasDbXref "FMA:67102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000409 ; owl:annotatedTarget "SA nodal myocyte" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000409 ; owl:annotatedTarget "SA node cardiac muscle cell" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000409 ; owl:annotatedTarget "sinoatrial node cell" . [] oboInOwl:hasDbXref "FMA:67102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000409 ; owl:annotatedTarget "sinuatrial node myocyte" . [] oboInOwl:hasDbXref "ISBN:08199377X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000286 ; owl:annotatedTarget "A cell of a filament of a fungal mycelium." . [] oboInOwl:hasDbXref "FMA:67106", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000410 ; owl:annotatedTarget "A muscle cell that is part of the atrioventricular node." . [] oboInOwl:hasDbXref "FMA:67106" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000410 ; owl:annotatedTarget "AV nodal myocyte" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000410 ; owl:annotatedTarget "AV node cardiac muscle cell" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000410 ; owl:annotatedTarget "AV node cell" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000410 ; owl:annotatedTarget "atrioventricular node cell" . [] oboInOwl:hasDbXref "FMA:67106" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000410 ; owl:annotatedTarget "atrioventricular node myocyte" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000411 ; owl:annotatedTarget "An endothelial cell that is part of the small intestine Peyer's patch." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000412 ; owl:annotatedTarget obo:CL_0000071 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000412 ; owl:annotatedTarget "An endothelial cell that is part of the arteriole." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000413 ; owl:annotatedTarget "A blood vessel endothelial cell that is part of an arterial endothelium." . [] oboInOwl:hasDbXref "DOI:10.1007/s00441-008-0706-5", "DOI:10.1007/s10456-021-09785-7", "DOI:10.1016/j.ccm.2021.08.005", "DOI:10.1016/j.jvs.2004.03.043", "DOI:10.1177/153857440303700107" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000413 ; owl:annotatedTarget """Endothelial cells of the artery, also referred to as arterial endothelial cells, form an integral part of the arterial system. They form a single layer, known as the endothelium, lining the interior surface of arteries, and are able to respond to the high-pressure and flow conditions present in arteries. The primary role of these cells is to provide a barrier between the vessel wall and the blood, exhibiting selective permeability to regulate the movement of liquids, gases, and blood-borne substances across the vascular wall. Arterial endothelial cells significantly contribute to maintaining vascular homeostasis. They are at the forefront of sensations and responses to mechanical stimuli, like shear stress and blood pressure changes. An additional key function pertains to the production of nitric oxide, which helps to regulate vascular tone and blood pressure, prevents platelet aggregation, limits leukocyte adhesion to the endothelium, and inhibits smooth muscle cell proliferation. These varied but connected functions help to preclude the development of atherosclerosis, ensuring normal circulation and arterial health. Moreover, these cells play a pivotal role in inflammation and coagulation processes. During inflammatory events, they express various adhesion molecules, aiding in leukocyte recruitment and rolling onto the vessel walls for immune response. They also produce anticoagulant and procoagulant substances, involved in blood clotting and clot dissolution, respectively. Dysregulation of the usual functions of arterial endothelial cells can result in serious pathophysiological conditions, such as atherosclerosis, hypertension, and other cardiovascular diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "endothelial cell of artery on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000413 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000413" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000414 ; owl:annotatedTarget "An endothelial cell that is part of the venule." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000415 ; owl:annotatedTarget "An epithelial cell that is part of the gallbladder." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000416 ; owl:annotatedTarget "OBSOLETE. A myoepithelial cell that is part of the mammary gland." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000417 ; owl:annotatedTarget obo:CL_0000185 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000417 ; owl:annotatedTarget "A myoepithelial cell that is part of the sweat gland." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM853.HLFH.534" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000417 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-hair-follicle/v1.0/assets/2d-ftu-skin-hair-follicle.png" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000418 ; owl:annotatedTarget "A myoepithelial cell that is part of the mammary gland alveolus." . [] oboInOwl:hasDbXref "FMA:67802" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000418 ; owl:annotatedTarget "basal cell of alveolus of lactiferous gland" . [] oboInOwl:hasDbXref "FMA:67802" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000418 ; owl:annotatedTarget "myoepithelial cell of mammary alveolus" . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000287 ; owl:annotatedTarget "Any photoreceptor cell that is part of some eye." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000419 ; owl:annotatedTarget "A myoepithelial cell that is part of the lactiferous duct." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000420 ; owl:annotatedTarget "A myoepithelial cell that is part of the terminal lactiferous duct." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000287 ; owl:annotatedTarget "ZFA:0009154" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000424 ; owl:annotatedTarget "A chromaffin cell that is part of the paraaortic body." . [] oboInOwl:hasDbXref "FMA:69328" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000424 ; owl:annotatedTarget "chromaffin cell of para-aortic body" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000425 ; owl:annotatedTarget obo:CL_0000166 . [] oboInOwl:hasDbXref "ISBN:047125208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000288 ; owl:annotatedTarget "Obsolete. Use PO:0000191 from Plant Ontology instead. A cell in the micropylar end of the embryo sac associated with the egg in the egg apparatus of angiosperms. Plays a vital role in fertilization." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000425 ; owl:annotatedTarget "A chromaffin cell that is part of the paraganglion." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000426 ; owl:annotatedTarget obo:CL_0000166 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000426 ; owl:annotatedTarget "A chromaffin cell that is part of the adrenal gland." . [] oboInOwl:hasDbXref "GO:0061104" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000426 ; owl:annotatedTarget "adrenal chromaffin cell" . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000290 ; owl:annotatedTarget "Obsolete. Use PO:0000274 from Plant Ontology instead. A fiber of the xylem tissue, Two types are recognized in the secondary xylem: fiber tracheids and libriform fibers." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000427 ; owl:annotatedTarget "A chromaffin cell that is part of the adrenal cortex." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000428 ; owl:annotatedTarget obo:CL_0000723 . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000292 ; owl:annotatedTarget "Obsolete. Use PO:0000293 from Plant Ontology instead. One of a pair of cells flanking the stomatal pore and causing the opening and closing of the pore by changes in turgor." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000428 ; owl:annotatedTarget "A somatic stem cell that is part of the epidermis." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_1000428 ; owl:annotatedTarget "ZFA:0007122" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FMA:70541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000428 ; owl:annotatedTarget "epidermal stem cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000432 ; owl:annotatedTarget obo:CL_0000066 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000432 ; owl:annotatedTarget "An epithelial cell that is part of the conjunctiva." . [] oboInOwl:hasDbXref "TAIR:sr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000293 ; owl:annotatedTarget "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." . [] oboInOwl:hasDbXref "FMA:70552" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000432 ; owl:annotatedTarget "epithelial cell of conjunctiva" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000433 ; owl:annotatedTarget "An epithelial cell that is part of the lacrimal canaliculus." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000293 ; owl:annotatedTarget "ZFA:0005745" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000434 ; owl:annotatedTarget "An epithelial cell that is part of the external acoustic meatus." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000435 ; owl:annotatedTarget obo:CL_0000072 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:22594785" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000435 ; owl:annotatedTarget "An epithelial cell that is part of the lacrimal drainage system." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000294 ; owl:annotatedTarget "Obsolete. Consult Plant Ontology instead. A type of sieve element that has relatively undifferentiated sieve areas (with narrow pores), rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000436 ; owl:annotatedTarget "An epithelial cell that is part of the lacrimal sac." . [] oboInOwl:hasDbXref "DOI:10.1007/s004290050160", "DOI:10.1111/j.1442-9071.2012.02818.x", "DOI:10.1167/tvst.8.4.32", "DOI:10.2147/OPTH.S26048", "DOI:10.3389/fimmu.2022.918619" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000436 ; owl:annotatedTarget """Epithelial cells of the lacrimal sac play a significant role in the physiology of tear drainage, acting as an integral part of the lacrimal drainage system. The lacrimal sac is part of the nasolacrimal duct system, a conduit which connects the eye to the nasal cavity, and is lined by multilayered, non-keratinizing, squamous epithelial cells. The epithelial cells of the lacrimal sac are specialized for the purpose of maintaining a moist environment and protecting the surface of the eye. They form a barrier that traps and removes potential contaminants from the tear film during the drainage process. These cells also actively contribute to tear turnover by expediting the drainage of excess tears. Dysfunctional epithelial cells of the lacrimal sac can lead to dacryocystitis, a condition characterized by inflammation of the lacrimal sac. Epithelial cells of the lacrimal sac also perform various other tasks which ensure the overall health of the eye. They are involved in the regulation of immune responses within the lacrimal apparatus and may have a possible role in host-microbiome interactions. Thus, epithelial cells of the lacrimal sac play a multifaceted role in tear drainage and ocular surface defence, directly translating to eye health and vision quality. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "epithelial cell of lacrimal sac on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000436 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000436" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000437 ; owl:annotatedTarget "An epithelial cell that is part of the nasolacrimal duct." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000438 ; owl:annotatedTarget "An epithelial cell that is part of the wall of inferior part of anal canal." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000441 ; owl:annotatedTarget "An epithelial cell that is part of the viscerocranial mucosa." . [] oboInOwl:hasDbXref "GOC:NV", "http://en.wikipedia.org/wiki/Neuroblast" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000031 ; owl:annotatedTarget "A cell that will develop into a neuron often after a migration phase." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000442 ; owl:annotatedTarget "An urothelial cell that is part of the trigone of urinary bladder." . [] oboInOwl:hasDbXref "FMA:70598" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000442 ; owl:annotatedTarget "epithelial cell of vesical trigone" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000443 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000443 ; owl:annotatedTarget "A smooth muscle cell that is part of the ciliary body." . [] oboInOwl:hasDbXref "DOI:10.1016/S1350-9462(98)00011-1", "DOI:10.1038/srep31171", "DOI:10.1111/j.1444-0938.2008.00260.x", "https://www.sciencedirect.com/topics/medicine-and-dentistry/ciliary-muscle" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000443 ; owl:annotatedTarget """Ciliary muscle cells are specialized contractile cells that constitute the ciliary muscle, a component of the eye in vertebrates. These cells form a ring around the iris, the eye's colored part. Ciliary muscle cells fall into the category of smooth muscle cells, characterized by their lack of the striations typical of skeletal and cardiac muscle cells. Their shape is elongated and pointed at both ends, and they occur in multi-nucleated syncytia where many cells share the same cytoplasm. Ciliary muscle cells primarily control the eye's accommodation, adjusting the thickness and curvature of the lens to fine-tune the focus of light on the retina. When ciliary muscle cells contract, tension on the zonular fibers holding the lens in place is reduced, allowing the lens to become thicker and increase its refractive power. Conversely, when the ciliary muscle cells relax, the tension on the zonular fibers increases, causing the lens to become flatter and decrease its refractive power. This adjustment facilitates clear vision at different distances, ranging from near to far objects. Additionally, ciliary muscle cells play a role in draining the eye's aqueous humor, which is the clear fluid that fills the anterior chamber of the eye between the cornea and the lens. By controlling the shape of the surrounding trabecular meshwork through muscle contractions and relaxations, ciliary muscle cells indirectly regulate intraocular pressure, a factor critical for preventing ocular conditions like glaucoma. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "FMA:70610" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000443 ; owl:annotatedTarget "smooth muscle cell of ciliary body" . [] a owl:Axiom ; rdfs:label "ciliary muscle cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000443 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000443" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000444 ; owl:annotatedTarget "A mesothelial cell that is part of the anterior chamber of eyeball." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000445 ; owl:annotatedTarget obo:CL_0000185 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000445 ; owl:annotatedTarget "A myoepithelial cell that is part of the dilatator pupillae." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000447 ; owl:annotatedTarget obo:CL_0000646 . [] oboInOwl:hasDbXref "GOC:tfm", "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000295 ; owl:annotatedTarget "A peptide hormone secreting cell that produces growth hormone, somatotropin." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000447 ; owl:annotatedTarget "A basal cell that is part of the epithelium of esophagus." . [] oboInOwl:hasDbXref "FMA:70731" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000447 ; owl:annotatedTarget "basal cell of esophageal epithelium" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000448 ; owl:annotatedTarget "An epithelial cell that is part of the sweat gland." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000295 ; owl:annotatedTarget "ZFA:0009155" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000449 ; owl:annotatedTarget "An epithelial cell that is part of the nephron." . [] oboInOwl:hasDbXref "DOI:10.1007/978-94-011-2354-9_6", "DOI:10.1007/s004670050586", "DOI:10.1016/B978-0-323-35775-3.00011-4", "DOI:10.1146/annurev-physiol-052521-121841", "DOI:10.1681/ASN.2012010029" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000449 ; owl:annotatedTarget """Epithelial cells of the nephron form the epithelial lining of the nephron, the functional unit of the kidney that filters the blood to produce urine. Each kidney holds approximately one million nephrons, each of which is composed of several distinct parts, including the renal corpuscle, the proximal tubule, the loop of Henle, and the distal tubule. All sections are lined with highly specialized epithelial cells adapted to perform different functions within the sections of the nephron. The different epithelial cells of the nephron play crucial roles in the process of filtration, reabsorption, secretion, and excretion, essential tasks for the regulation of body fluid composition and volume. During filtration, the blood is forced through the walls of glomerular capillaries into the Bowman's capsule, where waste products, electrolytes, and water are separated from the blood cells and proteins. As the filtrate then passes through the nephron, epithelial cells of the tubular portion reabsorb useful substances such as glucose, amino acids, and electrolytes, along with most of the water back into the bloodstream. Waste products like urea and creatinine, as well as excess ions and water, remain in the tubule for elimination. In addition, epithelial cells of the nephron also play a vital part in maintaining the body's acid-base balance by actively secreting hydrogen ions into the urine while reabsorbing bicarbonate from the urine back into the blood. They are also involved in the regulation of blood pressure through the renin-angiotensin-aldosterone system and contribute to erythrocyte production by releasing the hormone erythropoietin in response to low oxygen levels in the blood. Abnormalities or damage in renal epithelial cells often result in impaired kidney function, leading to various renal diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "epithelial cell of nephron on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000449 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000449" . [] oboInOwl:hasDbXref "ISBN:0140514031", "TAIR:lr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000296 ; owl:annotatedTarget "Obsolete. Use PO:0020099 from Plant Ontology instead. Cell type formed after the first mitotic division of the microgametophye, The nucleus of this cell migrates to the tip of the pollen tube after germination and disintegrates when the pollen tube penetrates the nucellus." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000450 ; owl:annotatedTarget "An epithelial cell that is part of the glomerular capsule." . [] oboInOwl:hasDbXref "FMA:70966" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000450 ; owl:annotatedTarget "epithelial cell of Bowman's capsule" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000452 ; owl:annotatedTarget "An epithelial cell that is part of the glomerular parietal epithelium." . [] oboInOwl:hasDbXref "FMA:70968" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000452 ; owl:annotatedTarget "epithelial cell of parietal layer of glomerular capsule" . [] oboInOwl:hasDbXref "PMID:10938806" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000297 ; owl:annotatedTarget "Obsolete. Use PO:0000115 from Plant Ontology instead. A cell that surrounds a trichome and provides support for the trichome." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM778.SHGJ.294" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000452 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000453 ; owl:annotatedTarget "An epithelial cell that is part of the intermediate tubule." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000298 ; owl:annotatedTarget "Obsolete. Use PO:0000273 from Plant Ontology instead. A cell composing the xylem." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000454 ; owl:annotatedTarget obo:CL_0000072 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000454 ; owl:annotatedTarget obo:CL_1001225 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000454 ; owl:annotatedTarget "An epithelial cell that is part of the collecting duct of renal tubule." . [] oboInOwl:hasDbXref "DOI:10.1016/j.ajpath.2014.01.014", "DOI:10.1016/j.semnephrol.2019.04.005", "DOI:10.2215/CJN.05760513", "DOI:10.2215/CJN.08880914" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000454 ; owl:annotatedTarget """Kidney collecting duct epithelial cells are a specialized type of cells that form an integral part of the renal system. Located in the collecting duct system of the kidneys, these cells are responsible for one of the final steps in the process of urine formation, and they are instrumental in the fine tuning of the volume and composition of urine by reabsorbing water and certain solutes back into the bloodstream. These cells express specific channels and carriers that actively and passively transport ions and water. They also have channels on their membranes, such as sodium channels and potassium channels, involved in reabsorbing or secreting these electrolytes depending upon the body's needs. The function of renal collecting duct epithelial cells can be regulated by a variety of hormones, including vasopressin (antidiuretic hormone), which can modulate the ion channels and carriers and hence indirectly influence body fluid homeostasis. Aside from their function in ion and water balance, kidney collecting duct epithelial cells also aid in maintaining the body's acid-base balance. They have specialized functionality to secret hydrogen ions into the tubular lumen, which contributes to acid excretion. Any dysfunction may have serious implications and lead to various renal or systemic diseases, exemplifying the importance of these cells in maintaining overall body homeostasis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "FMA:70982" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000454 ; owl:annotatedTarget "epithelial cell of renal collecting tubule" . [] a owl:Axiom ; rdfs:label "kidney collecting duct epithelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000454 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000454" . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000299 ; owl:annotatedTarget "OBSOLETED. Commonly used for a cell in root epidermis that gives rise to a root hair. The daughter cell produced by the asymmetric division of a root epidermal cell that gives rise to a root hair." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000456 ; owl:annotatedTarget "A mesothelial cell that is part of the parietal peritoneum." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000457 ; owl:annotatedTarget "A mesothelial cell that is part of the visceral peritoneum." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000031 ; owl:annotatedTarget "ZFA:0009011" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000458 ; owl:annotatedTarget obo:CL_0000148 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000458 ; owl:annotatedTarget "A melanocyte that is part of the skin of body." . [] oboInOwl:hasDbXref "DOI:10.1016/j.jinf.2015.06.006", "DOI:10.1111/j.1751-1097.2007.00226.x", "DOI:10.1615/CritRevEukaryotGeneExpr.2020028454", "DOI:10.5114/pdia.2013.33376", "https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/melanocyte" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000458 ; owl:annotatedTarget """Melanocytes of the skin are specialized pigment cells crucial for producing and distributing melanin, the pigment determining skin, in addition to hair and eye color. Located in the basal layer of the epidermis, melanocytes serve as a natural sunscreen, protecting skin cells from harmful UV radiation. Structurally dendritic, they synthesize melanin through melanogenesis, transferring melanosomes to keratinocytes for UV shielding Beyond pigmentation and UV protection, melanocytes play roles in immune and inflammatory responses. They respond to environmental changes, communicate with skin cell types, and secrete cytokines and growth factors influencing skin homeostasis. Dysregulation may lead to pigment disorders like vitiligo and melasma or contribute to skin cancer, particularly malignant melanoma. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "FMA:72144" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000458 ; owl:annotatedTarget "skin melanocyte" . [] a owl:Axiom ; rdfs:label "melanocyte of skin on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000458 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000458" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM642.BMZS.772" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000458 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-epidermal-ridge/v1.2/assets/2d-ftu-skin-epidermal-ridge.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000465 ; owl:annotatedTarget obo:CL_0000166 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000465 ; owl:annotatedTarget "A chromaffin cell that is part of the ovary." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000466 ; owl:annotatedTarget "A chromaffin cell that is part of the right ovary." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000467 ; owl:annotatedTarget "A chromaffin cell that is part of the left ovary." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000468 ; owl:annotatedTarget "A myoepithelial cell that is part of the acinus of lactiferous gland." . [] oboInOwl:hasDbXref "FMA:74469" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000468 ; owl:annotatedTarget "basal cell of acinus of lactiferous gland" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000469 ; owl:annotatedTarget "A myoepithelial cell that is part of the main lactiferous duct." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000470 ; owl:annotatedTarget "A myoepithelial cell that is part of the primary lactiferous duct." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000471 ; owl:annotatedTarget "A myoepithelial cell that is part of the secondary lactiferous duct." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000472 ; owl:annotatedTarget "A myoepithelial cell that is part of the tertiary lactiferous duct." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000473 ; owl:annotatedTarget "A myoepithelial cell that is part of the quarternary lactiferous duct." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000477 ; owl:annotatedTarget "A nodal myocyte that is part of the sinoatrial node." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000478 ; owl:annotatedTarget obo:CL_0002073 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000478 ; owl:annotatedTarget "A transitional myocyte that is part of the sinoatrial node." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000479 ; owl:annotatedTarget obo:CL_0002068 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000479 ; owl:annotatedTarget "A Purkinje myocyte that is part of the atrioventricular node." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000480 ; owl:annotatedTarget obo:CL_0002073 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000480 ; owl:annotatedTarget "A transitional myocyte that is part of the internodal tract." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000481 ; owl:annotatedTarget obo:CL_0002073 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000481 ; owl:annotatedTarget "A transitional myocyte that is part of the atrioventricular bundle." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000482 ; owl:annotatedTarget obo:CL_0002074 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000482 ; owl:annotatedTarget "A myocardial endocrine cell that is part of the interventricular septum." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000300 ; owl:annotatedTarget obo:CL_0000586 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000483 ; owl:annotatedTarget obo:CL_0002068 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000483 ; owl:annotatedTarget "A Purkinje myocyte that is part of the internodal tract." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000484 ; owl:annotatedTarget obo:CL_0002068 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000300 ; owl:annotatedTarget "A mature sexual reproductive cell having a single set of unpaired chromosomes." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000484 ; owl:annotatedTarget "A Purkinje myocyte that is part of the atrioventricular bundle." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000486 ; owl:annotatedTarget obo:CL_0000646 . [] oboInOwl:hasDbXref "GOC:tfm", "doi:10.1038/s41385-022-00565-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000486 ; owl:annotatedTarget "A basal cell that is part of the urothelium. Compared to other urothelial cell types, a basal cell of the urothelium is positioned along the basement membrane, is the most undifferentiated and serves a progenitor role." . [] oboInOwl:hasDbXref "doi:10.1007/978-3-030-14366-4_8", "doi:10.1111/cpr.13170" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000486 ; owl:annotatedTarget "urothelial basal cell" . [] oboInOwl:hasDbXref "doi:10.1038/s41385-022-00565-0" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_1000486 ; owl:annotatedTarget "It has been noted in at least some mammalian species that the urothelial basal cell type is distinguished by expression of high levels of cytokeratin-5 (CK5), p63 and the signalling molecule Sonic hedgehog (Shh). Similar to intermediate cells, the urothelial basal cell type expresses CK17 but is negative for uroplakins (UPK) and CK20. Urothelial basal cells have also been noted to be smaller in diameter than urothelial intermediate cells." . [] oboInOwl:hasDbXref "DOI:10.1038/s41586-020-2347-0", "DOI:10.3389/fcell.2022.1040708", "https://www.ncbi.nlm.nih.gov/books/NBK10008/", "https://www.ncbi.nlm.nih.gov/books/NBK553142/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000300 ; owl:annotatedTarget """Gametes are reproductive cells essential for sexual reproduction in eukaryotic organisms, including humans, animals, and many plants. These cells are haploid, containing half the genome or only one set of chromosomes, which is a contrast to the diploid state (two sets of chromosomes) found in most cells in a multicellular organism. This reduction in genetic material is crucial since it allows for the re-establishment of the diploid number of chromosomes when two gametes merge to form a diploid zygote during fertilization. There are two major types of gametes in animals: sperm cells in males and egg (or ova) in females. These gametes contribute equally to the genetic makeup of the offspring but are morphologically and functionally distinct. Sperm cells (or spermatozoa) are characterized by their motility, small size, and large quantities; they are produced continuously in vast numbers through a process called spermatogenesis in the male gonads or testes. Female gametes are much larger, fewer in numbers, and are not motile; they undergo a development process known as oogenesis, which takes place within the ovaries. The egg also contributes most of the cytoplasm and organelles (including mitochondria) to the zygote that are required for initial cell division stages after fertilization. Gametes have a primary role in sexual reproduction and genetic variation, which aids in evolution. The formation of gametes involves a special type of cell division called meiosis that introduces genetic diversity via the process of recombination and independent assortment. Following the fusion of male and female gametes, the combination of paternal and maternal genetic material in the zygote allows for genetic recombination, which is a fundamental source of genetic variation and, thus, evolution. Therefore, gametes not only are critical to the inception of new individuals but also contribute to species survival and evolution. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000487 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000487 ; owl:annotatedTarget "A smooth muscle cell that is part of the prostate gland." . [] oboInOwl:hasDbXref "DOI:10.1101/cshperspect.a030510", "https://www.ncbi.nlm.nih.gov/books/NBK279291", "https://www.sciencedirect.com/topics/immunology-and-microbiology/smooth-muscle-cell" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000487 ; owl:annotatedTarget """Smooth muscle cells of the prostate constitute a critical component of the prostatic stroma, enveloping glandular structures to support functions like secretion and fluid expulsion. Like other smooth muscles, smooth muscle cells of the prostate lack the striations characteristic of skeletal and cardiac muscle cell. Functionally, they play a crucial role in reproductive and urinary functions. Smooth muscle cells of the prostate contribute to the transport and expulsion of prostatic secretions into the urethra and respond dynamically to signaling molecules such as hormones and neurotransmitters. For instance, under sympathetic nervous stimulation, they contract and apply pressure on the gland's ducts, facilitating the secretion process. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "FMA:84583" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000487 ; owl:annotatedTarget "smooth muscle fiber of prostate" . [] a owl:Axiom ; rdfs:label "smooth muscle cell of prostate on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000487 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000487" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM347.TXWZ.899" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000487 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000300 ; owl:annotatedTarget "FBbt:00005412" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000300 ; owl:annotatedTarget "ZFA:0009156" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000488 ; owl:annotatedTarget obo:CL_0000069 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:16550043", "PMID:18356246" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000488 ; owl:annotatedTarget "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." . [] oboInOwl:hasDbXref "DOI:10.1016/j.jcmgh.2015.05.005", "DOI:10.1016/j.jhep.2012.10.011", "DOI:10.1038/s41575-019-0125-y", "DOI:10.1152/ajpgi.00227.2012", "DOI:10.5009/gnl16033" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000488 ; owl:annotatedTarget """Cholangiocytes, also known as biliary epithelial cells, are specialized epithelial cells that line the biliary tract, which constitutes the gall bladder and bile ducts inside the liver. Crucial to the maintenance of the liver's health and function, cholangiocytes have a key role in the modification and secretion of bile, a fluid produced by hepatocytes that is essential to digestion and the absorption of fats and vitamins. Cholangiocytes accomplish their primary function through the expression of a variety of transport proteins located on their apical and basolateral membranes, which propel bile acids and other contents of the bile into the biliary lumen. The hepatic bile, once secreted by the hepatocytes, is further modified by cholangiocytes via secretion and absorption processes. These processes help in the regulation of bile volume and composition, which is fundamental in ensuring the efficient digestion of dietary fats and fat-soluble vitamins and the excretion of cholesterol. In addition to their role in bile modification, cholangiocytes also perform several other integral functions. For instance, these cells express Toll-like receptors (TLRs) which allow cholangiocytes to initiate an immune response against pathogens in the biliary lumen. When functioning normally, these cells contribute to biliary integrity, hepatic architecture, and overall hepatic physiology. However, when they become pathological, they are involved in the progression of liver diseases, such as primary biliary cirrhosis and cholangiocarcinoma – the malignancy of the biliary tract. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_1000488 ; owl:annotatedTarget "ZFA:0009397" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "cholangiocyte on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000488 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000488" . [] a owl:Axiom ; rdfs:label "gamete on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000300 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000300" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000489 ; owl:annotatedTarget obo:CL_0000432 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000489 ; owl:annotatedTarget "A reticular cell that is part of the splenic cord." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM559.FNBB.6273" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000489 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-white-pulp/v1.2/assets/2d-ftu-spleen-white-pulp.png" . [] oboInOwl:hasDbXref "doi:10.1017/CBO9780511818202.015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000301 ; owl:annotatedTarget "A primordial germ cell of insects. Such cells form at the posterior pole of the early embryo." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000490 ; owl:annotatedTarget "A mesothelial cell that is part of the peritoneum." . [] oboInOwl:hasDbXref "FMA:86736" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000490 ; owl:annotatedTarget "peritoneal mesothelial cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000491 ; owl:annotatedTarget "A mesothelial cell that is part of the pleura." . [] oboInOwl:hasDbXref "DOI:10.1016/j.ccm.2021.08.005", "DOI:10.1016/j.coi.2020.04.005", "DOI:10.1152/ajplung.90587.2008", "DOI:10.3389/fphys.2014.00284" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000491 ; owl:annotatedTarget """Mesothelial cells of the pleura form a significant part of the pleural membrane, a thin, double-layered serous membrane that lines the thoracic cavity and encompasses the lungs. These specialized cells contribute to the pleura's key function of producing a lubricating serous fluid, which reduces friction between the lung's outer surface (visceral pleura) and the inner lining of the thoracic cavity (parietal pleura) during respiration. The cellular structure of mesothelial cells, characterized by microvilli on their surface, aids in the secretion and absorption of the pleural fluid, effectively supporting the smooth expansion and contraction of the lungs. Dysregulation in mesothelial cells can lead to pathologies, including pleural effusion and malignant mesothelioma. Mesothelial cells of the pleura display unique immunologic properties. They act as a first line of defense against infection because they are able to recognize pathogens and respond by secreting various cytokines and chemokines. Additionally, these cells are directly involved in the translocation of immune cells into the pleural cavity during inflammatory response, thereby playing an active role in the immune response within the pleural environment. In the event of pleural injury, these cells are also involved in the mesothelial-mesenchymal transition, a process that allows mesothelial cells to transdifferentiate into myofibroblasts and promote tissue repair. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000301 ; owl:annotatedTarget "FBbt:00000092" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FMA:86737" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000491 ; owl:annotatedTarget "pleural mesothelial cell" . [] a owl:Axiom ; rdfs:label "mesothelial cell of pleura on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000491 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000491" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000492 ; owl:annotatedTarget "A mesothelial cell that is part of the parietal pleura." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000493 ; owl:annotatedTarget "A mesothelial cell that is part of the visceral pleura." . [] oboInOwl:hasDbXref "DOI:10.1016/S1357-2725(03)00242-5", "DOI:10.1152/physrev.00026.2003", "DOI:10.1371/journal.pone.0276978", "DOI:10.3389/fphys.2014.00221", "DOI:10.3390/jdb7020007" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000493 ; owl:annotatedTarget """Mesothelial cells of visceral pleura are specialized epithelial cells that line the inner layer of the pleura, the membrane that envelops the lungs. Positioned adjacent to the lung tissue, these cells form a protective barrier and contribute to the structure of the visceral pleura. They are characterized by their cuboidal to squamous epithelial shape and the presence of microvilli on their surface, a feature aiding in fluid and solute exchange between the pleura and the lungs. The primary function of mesothelial cells of visceral pleura is to secrete a lubricating serous fluid to facilitate smooth, frictionless lung movement within the thoracic cavity during respiration. This helps in the prevention of trauma or damage stemming from the constant rubbing of the lung tissue against the chest wall, hence playing a pivotal role in maintaining respiratory function. Besides fluid secretion, these cells have an essential role in the transportation of fluids and particles across the pleura, as well as in inflammation, wound healing, and tissue repair processes within the pleura. Mesothelial cells of visceral pleura are notably implicated in the development of pleural diseases such as pleural effusion and pleural mesothelioma, a rare and aggressive form of cancer primarily linked with exposure to asbestos. Alterations, such as hyperplasia or metaplasia, may occur in these mesothelial cells under pathological conditions. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "mesothelial cell of visceral pleura on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000493 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000493" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000494 ; owl:annotatedTarget "An epithelial cell that is part of a nephron tubule." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000495 ; owl:annotatedTarget "A goblet cell that is part of the small intestine." . [] oboInOwl:hasDbXref "FMA:86929" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000495 ; owl:annotatedTarget "small intestinal goblet cell" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_1000497 ; owl:annotatedTarget "ZFA:0009389" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_1000500 ; owl:annotatedTarget "ZFA:0009390" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:22343825" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000504 ; owl:annotatedTarget "A cell that is part of a renal medulla." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_1000504 ; owl:annotatedTarget "ZFA:0009391" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000032 ; owl:annotatedTarget "A cell of a platelike structure, especially a thickened plate of ectoderm in the early embryo, from which a sense organ develops." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000510 ; owl:annotatedTarget "Any kidney epithelial cell that is part of some glomerular epithelium." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000307 ; owl:annotatedTarget obo:CL_0002202 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000307 ; owl:annotatedTarget "An epithelial cell found in the trachea." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000550 ; owl:annotatedTarget "Any kidney cell that is part of some papillary duct." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000311 ; owl:annotatedTarget "ZFA:0009157" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000596 ; owl:annotatedTarget "Any kidney cell that is part of some juxtamedullary cortex." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000600 ; owl:annotatedTarget "Any cell that is part of some lower urinary tract." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000601 ; owl:annotatedTarget "Any cell that is part of some ureter." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000606 ; owl:annotatedTarget "Any neuron that has its soma located in some kidney." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000612 ; owl:annotatedTarget "Any renal cortical epithelial cell that is part of some renal corpuscle." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000615 ; owl:annotatedTarget obo:CL_1000507 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000312 ; owl:annotatedTarget obo:CL_0000237 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000615 ; owl:annotatedTarget "Any kidney tubule cell that is part of some renal cortex tubule." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000616 ; owl:annotatedTarget obo:CL_1000504 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000616 ; owl:annotatedTarget "Any kidney medulla cell that is part of some outer medulla of kidney." . [] oboInOwl:hasDbXref "PMID:15749908", "PMID:19256306", "PMID:19727116", "PMID:29713660", "PMID:37873034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000312 ; owl:annotatedTarget "An epithelial cell of stratified squamous tissues, including skin, oral mucosa (Hiroshima et al., 2011), and esophagus (Whelan et al., 2018), that produces keratin proteins and secretes antimicrobial peptides to form a resilient barrier against environmental damage, dehydration, pathogens, and microbial invasion. It undergoes successive stages of differentiation marked by changes in keratin expression, supporting tissue integrity, wound repair, and contributing to immune defense." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000617 ; owl:annotatedTarget obo:CL_1000504 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000617 ; owl:annotatedTarget "Any kidney medulla cell that is part of some inner medulla of kidney." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000312 ; owl:annotatedTarget "ZFA:0009158" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000618 ; owl:annotatedTarget obo:CL_0002681 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000618 ; owl:annotatedTarget "Any kidney cortical cell that is part of some juxtaglomerular apparatus." . [] oboInOwl:hasDbXref "GO:0072052" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000618 ; owl:annotatedTarget "juxtaglomerulus cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000681 ; owl:annotatedTarget obo:CL_1000500 . [] oboInOwl:hasDbXref "PMID:18575881" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000681 ; owl:annotatedTarget "A cell that is part of an interstitial compartment of a renal cortex." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000032 ; owl:annotatedTarget "ZFA:0009012" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000313 ; owl:annotatedTarget "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000682 ; owl:annotatedTarget obo:CL_1000500 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000682 ; owl:annotatedTarget obo:CL_1000504 . [] oboInOwl:hasDbXref "PMID:21359760" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000682 ; owl:annotatedTarget "A cell that is part of an interstitum of a renal medulla." . [] oboInOwl:hasDbXref "PMID:10559635" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000692 ; owl:annotatedTarget "A fibroblast that is part of an interstitial compartment of a kidney." . [] oboInOwl:hasDbXref "DOI:10.1016/bs.ircmb.2022.01.005", "DOI:10.1172/jci.insight.161078", "DOI:10.3389/fimmu.2021.681748", "DOI:10.3389/fphys.2017.00837" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000698 ; owl:annotatedTarget """Kidney resident macrophages are a heterogeneous population of immune cell found in the cortex and medullary regions of the kidney as well as within and surround the glomeruli. Their primary role involves maintaining homeostasis and immune surveillance in the kidney microenvironment, defending against ascending urinary infections. Beyond traditional macrophage roles such as phagocytosis and antigen presentation, kidney resident macrophages also contribute significantly to the response to kidney injury including tissue repair and angiogenesis. Under normal physiological conditions, kidney resident macrophages work to maintain the balance of the kidney's microenvironment by removing dead cells, pathogens and cellular debris, to limit inflammation and tissue damage. They are ‘professional’ phagocytes, clearing pathogens and debris by engulfing and digesting these harmful materials. Moreover, they are capable of presenting antigens to other immune cells, which aids in the activation of the adaptive immune response. Kidney resident macrophages show a high degree of plasticity: in response to environmental stimuli they change their morphology and cell surface markers. For example, in response to acute injury, some macrophages adopt a pro-inflammatory phenotype and augment tissue damage; once the injury stimulus is removed, they may change to mediate tissue repair. While kidney macrophages contribute to wound healing, tissue repair and regeneration by producing key growth factors and cytokines that stimulate cell proliferation, collagen production, and blood vessel formation, dysregulation in their activity can also lead to progressive inflammation and fibrosis, common features in chronic kidney disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "kidney resident macrophage on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000698 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000698" . [] oboInOwl:hasDbXref "PMID:25266210" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000699 ; owl:annotatedTarget "A resident-dendritic cell that is part of a kidney." . [] oboInOwl:hasDbXref "MESH:D013666" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000315 ; owl:annotatedTarget "A cell secreting tears, the fluid secreted by the lacrimal glands. This fluid moistens the conjunctiva and cornea." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000702 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000702 ; owl:annotatedTarget obo:CL_1000505 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000702 ; owl:annotatedTarget "Any smooth muscle cell that is part of some kidney pelvis smooth muscle." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000703 ; owl:annotatedTarget obo:CL_0002518 . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000316 ; owl:annotatedTarget "Obsolete. Use PO:0000082 from Plant Ontology instead. A meristemic ray cell in the vascular cambium that gives rise to ray cells of the secondary xylem and secondary phloem." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000703 ; owl:annotatedTarget obo:CL_1000505 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000703 ; owl:annotatedTarget "Any kidney epithelial cell that is part of some kidney pelvis urothelium." . [] oboInOwl:hasDbXref "PMID:36180582" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000706 ; owl:annotatedTarget "A urothelial cell that is part of the urothelium of ureter." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000708 ; owl:annotatedTarget obo:CL_1000601 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000708 ; owl:annotatedTarget "Any ureteral cell that is part of some adventitia of ureter." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000714 ; owl:annotatedTarget obo:CL_1000549 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000714 ; owl:annotatedTarget "Any renal principal cell that is part of some cortical collecting duct." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM483.MXQP.399" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000714 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-cortical-collecting-duct/v1.3/assets/2d-ftu-kidney-cortical-collecting-duct.png" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM927.DQNW.448" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000714 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000715 ; owl:annotatedTarget obo:CL_1000549 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000715 ; owl:annotatedTarget "Any renal intercalated cell that is part of some cortical collecting duct." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000716 ; owl:annotatedTarget obo:CL_1000548 . [] oboInOwl:hasDbXref "PMID:25632105" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000716 ; owl:annotatedTarget "Principal cell that is part of some outer medullary collecting duct. It is known in some mammalian species that this cell may express the epithelial sodium channel (ENaC)." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM927.DQNW.448" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000716 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM724.KFSK.483" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000716 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-outer-medullary-collecting-duct/v1.2/assets/2d-ftu-kidney-outer-medullary-collecting-duct.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000717 ; owl:annotatedTarget obo:CL_1000548 . [] oboInOwl:hasDbXref "PMID:25632105" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000717 ; owl:annotatedTarget "Intercalated cell that is part of some outer medullary collecting duct. It is known in some mammalian species that this cell may contribute in the maintenance of acid/base homeostasis." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM724.KFSK.483" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000717 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-outer-medullary-collecting-duct/v1.2/assets/2d-ftu-kidney-outer-medullary-collecting-duct.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000718 ; owl:annotatedTarget obo:CL_1000547 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000718 ; owl:annotatedTarget "Any renal principal cell that is part of some inner medullary collecting duct." . [] oboInOwl:hasDbXref "MESH:D012629", "PMID:19944183" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000317 ; owl:annotatedTarget "An epithelial cell that is part of a sebaceous gland. This cell produces and secretes sebum, an oily, lipid-rich substance, through holocrine secretion where the entire cell ruptures to release its contents." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM268.TNSF.557" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000718 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-inner-medullary-collecting-duct/v1.2/assets/2d-ftu-kidney-inner-medullary-collecting-duct.png" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM927.DQNW.448" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000718 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000719 ; owl:annotatedTarget obo:CL_1000547 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000719 ; owl:annotatedTarget "Any renal intercalated cell that is part of some inner medullary collecting duct." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM853.HLFH.534" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000317 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-hair-follicle/v1.0/assets/2d-ftu-skin-hair-follicle.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000720 ; owl:annotatedTarget obo:CL_1000550 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000720 ; owl:annotatedTarget "Any renal intercalated cell that is part of some papillary duct." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000721 ; owl:annotatedTarget obo:CL_1000550 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000721 ; owl:annotatedTarget "Any renal principal cell that is part of some papillary duct." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544", "PMID:25960390" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000033 ; owl:annotatedTarget "An exocrine cell characterized by loss of part of the cytoplasm during the process of secretion. The secreted substance is accumulated at the apical end and is either budded off through the plasma membrane producing secreted vesicles or dissolved in the cytoplasm that is lost during secretion." . [] oboInOwl:hasDbXref "MESH:D013542" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000318 ; owl:annotatedTarget "A cell secreting sweat, the fluid excreted by the sweat glands of mammals. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products." . [] oboInOwl:hasDbXref , "Wikipedia:Intraglomerular_mesangial_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000742 ; owl:annotatedTarget "A mesangial cell located among the glomerular capillaries in a renal corpuscle." . [] oboInOwl:hasDbXref "CL:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000742 ; owl:annotatedTarget "intraglomerular mesangial cell" . [] oboInOwl:hasDbXref "PMID:9127003", "https://doi.org/10.1152/physrev.1998.78.3.723" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_1000742 ; owl:annotatedTarget "Like smooth muscle, a glomerular mesangial cell is contractile and possesses the filaments actin and myosin. The contractile mechanism is also similar to that of smooth muscle, with Ca2+/calmodulin-activated myosin light-chain kinase instigating myosin-actin cross-bridge cycling. Mesangial cell phagocytosis of apoptotic neutrophils involves a novel CD36-independent, alpha(v)beta3/TSP-mediated mechanism that is uncoupled from chemokine secretion, emphasizing the injury-limiting potential of mesangial cell phagocytosis of apoptotic cells." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM778.SHGJ.294" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000742 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000746 ; owl:annotatedTarget "Any kidney corpuscule cell that is part of some renal glomerulus." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000768 ; owl:annotatedTarget obo:CL_1000494 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000768 ; owl:annotatedTarget "Any nephron tubule epithelial cell that is part of some renal connecting tubule." . [] oboInOwl:hasDbXref "DOI:10.1002/cphy.c110052", "DOI:10.1007/s00418-021-02033-5", "DOI:10.1097/MNH.0b013e32820ac850", "DOI:10.1681/ASN.2019040415", "DOI:10.23876/j.krcp.2017.36.4.305" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000768 ; owl:annotatedTarget """Kidney connecting tubule epithelial cells are found in collecting duct system of the kidney, specifically in at the interconnection segment between the nephron and the collecting ducts. The epithelial cells lining the connecting tubule are crucial for the journey of filtrate before it empties into urine-collecting ducts and therefore play a critical role in maintaining the body’s fluid and electrolyte balance. One of the principal functions of connecting tubule epithelial cells involves the selective reabsorption and secretion of various solutes. This reabsorption process includes critical regulatory electrolytes such as sodium ions (Na+), chloride ions (Cl-), and bicarbonate ions (HCO3-), thus playing a role in the regulation of the acid-base homeostasis. Their function also involves the secretion of potassium ions (K+) into the renal tubular fluid. The connecting tubule epithelial cells are primarily intercalated cells, which can be categorized into two types according to their specific functions: type A intercalated cells, which secrete acid, and the type B intercalated cells, which secrete base (bicarbonate) and reabsorb chloride. By regulating the concentrations of these ions, as well as reabsorption of water, connecting tubule epithelial cells contribute substantively to maintaining the body's electrolyte levels, pH balance, and overall homeostasis. In addition to intercalating cells, the collecting duct system also has principal cells, which are characterized by the expression of the water channel AQP2. AQP2-expressing cells have also been identified in connecting tubules, but there is some controversy whether these represent a unique cell type as there are some morphologic differences compared with principal cells. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "kidney connecting tubule epithelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000768 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000768" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM927.DQNW.448" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000768 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000803 ; owl:annotatedTarget obo:CL_1000617 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000803 ; owl:annotatedTarget obo:CL_1000682 . [] oboInOwl:hasDbXref "PMID:21359760" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000803 ; owl:annotatedTarget "A cell that is part of an interstitial compartment of an inner renal medulla." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000804 ; owl:annotatedTarget obo:CL_1000616 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000804 ; owl:annotatedTarget obo:CL_1000682 . [] oboInOwl:hasDbXref "PMID:8694267" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000804 ; owl:annotatedTarget "A kidney cell that is part of an interstitial compartment of an outer renal medulla." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000838 ; owl:annotatedTarget "Any epithelial cell of proximal tubule that is part of some proximal convoluted tubule and has part some brush border." . [] oboInOwl:hasDbXref "DOI:10.1002/cphy.c110060", "DOI:10.1146/annurev-physiol-052521-121841", "DOI:10.1159/000092212", "DOI:10.1681/ASN.2019040415" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000838 ; owl:annotatedTarget """Kidney proximal convoluted tubule epithelial cells line the most voluminous part of the kidney's nephron, the proximal convoluted tubule, located in the cortex of the kidney. These cells are primarily involved in reabsorption and secretion processes, key functions that facilitate homeostasis within the body. Proximal convoluted tubule epithelial cells extensively function in the reabsorption process to a greater degree than their counterparts in the proximal straight tubule. Approximately two-thirds of filtrated sodium and water, nearly all nutrient sugars and amino acids, and a significant portion of bicarbonates pass through the proximal convoluted tubule, are effectively absorbed by the epithelial cells, and reenter the bodily circulation. By absorbing bicarbonates and secreting protons into the tubular fluid, proximal convoluted tubule epithelial cells also contribute to the pH regulation in the body . In addition to reabsorption, proximal convoluted tubule epithelial cells also play a critical role in the excretion of waste metabolites and xenobiotics. These cells possess a range of transporters that secrete metabolic end products and certain drugs, hence aiding in their elimination. This function underlines their importance for body detoxification. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "kidney proximal convoluted tubule epithelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000838 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000838" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000839 ; owl:annotatedTarget obo:CL_0002306 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000839 ; owl:annotatedTarget obo:CL_1000616 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000839 ; owl:annotatedTarget "Any epithelial cell of proximal tubule that is part of some proximal straight tubule." . [] oboInOwl:hasDbXref "DOI:10.1002/cphy.c110061", "DOI:10.1038/nrd4461", "DOI:10.1146/annurev-physiol-052521-121841", "DOI:10.1681/ASN.2019040415", "DOI:10.2215/CJN.10391012" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000839 ; owl:annotatedTarget """Kidney proximal straight tubule epithelial cells line the straight portion of the proximal tubule of the nephron, extending from the cortical medullary ray into the outer stripe of the outer medulla. They are characterized by a brush border of dense microvilli on their apical surface, enhancing the cell's surface area and aiding reabsorption, though reabsorption occurs more heavily in the proximal convoluted tubule preceding the straight portion of the tubule. The primary function of the kidney proximal straight tubule epithelial cells is to reabsorb the filtrate that the kidney produces, which includes glucose, sodium, and water. The reabsorption occurs through both passive and active transport methods. These cells exhibit enzyme-rich microvilli that also absorb small proteins and peptides. Consequently, they are involved in the regulation of plasma levels of various substances, including glucose, amino acids, and electrolytes, and maintain the body's pH homeostasis by secreting H+ ions into the urine and absorbing bicarbonate ions. These cells are also reported to be involved in drug metabolism. Many drugs are filtered from the blood by the kidneys and subsequently reabsorbed by the kidney proximal tubule epithelial cells back into the bloodstream. Furthermore, these cells play a significant role in the progression of kidney diseases. For example, in diabetic nephropathy and acute kidney injury, kidney proximal straight tubule epithelial cells can undergo cellular changes and result in malfunctions such as reduced reabsorption and increased excretion. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "kidney proximal straight tubule epithelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000839 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000839" . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000319 ; owl:annotatedTarget "Any cell that is capable of some mucus secretion." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000849 ; owl:annotatedTarget obo:CL_0002305 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000849 ; owl:annotatedTarget "Any epithelial cell of distal tubule that is part of some distal convoluted tubule." . [] oboInOwl:hasDbXref "DOI:10.1002/cphy.c140002", "DOI:10.1007/s40620-021-01032-y", "DOI:10.1152/physrev.2000.80.1.277", "DOI:10.1681/ASN.2019040415", "DOI:10.2215/CJN.05920613" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000849 ; owl:annotatedTarget """Kidney distal convoluted tubule epithelial cells, often referred to simply as distal convoluted tubule (DCT) cells, constitute a significant portion of the nephron -- the functional building unit of the kidney involved in filtration and reabsorption of substances from blood. The DCT epithelial cells form lining of the distal convoluted tubule, a segment of the nephron located after the loop of Henle and before the collecting tubule. These cells are characterized by unique morphological features such as small size, low height and fewer microvilli compared to proximal convoluted tubule epithelial cells. These cells perform a host of vital functions contributing to the regulation of extracellular fluid volume and electrolyte balance, blood pressure and pH. While the DCT is less prominent in water and sodium reabsorption compared to the proximal tubule and the loop of Henle, it plays a crucial role in fine-tuning the process. DCT epithelial cells are responsible for the final adjustments of sodium, potassium and calcium reabsorption, thereby affecting overall fluid and electrolyte balance, blood pressure regulation and bone health. The reabsorption process is regulated by hormones including aldosterone and parathyroid hormone. The distal convoluted tubule (DCT) also plays a significant role in acid-base homeostasis by secreting protons (H+) into the tubular fluid and reabsorbing bicarbonate ions (HCO3-), thus regulating the pH of the blood. The ability of DCT cells to adjust urine concentration plays a part in maintaining the body’s pH balance and preventing conditions like acidosis or alkalosis. In summary, kidney distal convoluted tubule epithelial cells perform functions that are crucial to maintaining body's homeostasis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "kidney distal convoluted tubule epithelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000849 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000849" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM927.DQNW.448" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000849 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000319 ; owl:annotatedTarget "ZFA:0009159" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000850 ; owl:annotatedTarget obo:CL_1000618 . [] oboInOwl:hasDbXref "PMID:33491562", "PMID:36142420", "Wikipedia:Macula_densa" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000850 ; owl:annotatedTarget "An epithelial cell that is part of the macula densa, characterized by a tightly packed arrangement, apically positioned nuclei, and prominent primary cilia, creating a distinctive 'dense spot' appearance under microscopy. It is involved in regulating renal blood flow, glomerular filtration rate, and renin release." . [] oboInOwl:hasDbXref "DOI:10.1073/pnas.0736323100", "DOI:10.1146/annurev-physiol-052521-121841", "DOI:10.1161/HYPERTENSIONAHA.115.04739", "DOI:10.1681/ASN.2009070759", "DOI:10.1681/ASN.2015050515" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1000850 ; owl:annotatedTarget """Macula densa epithelial cells, as part of the complex nephron structure, play a crucial role in kidney function. These cells, which make up the macula densa, help regulate blood pressure and the filtration rate of the glomerulus by sensing sodium chloride amounts in the kidney tubules. Found where the thick ascending limb of the Loop of Henle touches the afferent arteriole, macula densa epithelial cells are positioned in an optimal location to monitor and respond to changes in the filtrate composition. These cells maintain intraglomerular homeostasis. When the sodium chloride concentration is high, macula densa cells respond by secreting adenosine and vasoconstricting the afferent arteriole to decrease the glomerular filtration rate. Conversely, if the sodium chloride concentration in the filtrate is low, the production and release of nitric oxide cause vasodilation to enhance the glomerular filtration rate. Macula densa epithelial cells also have a role in tubuloglomerular feedback mechanisms, an essential autoregulatory renal response. They send feedback to the glomerular mesangial cells, allowing constriction or relaxation of the afferent arteriole as needed depending on the content of the filtrate. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "PMID:33491562" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000850 ; owl:annotatedTarget "macula densa cell" . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000320 ; owl:annotatedTarget "Obsolete. Use PO:0000431 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and produces four haploid (1n) megaspores; also called megaspore mother cell." . [] a owl:Axiom ; rdfs:label "macula densa epithelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1000850 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1000850" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM927.DQNW.448" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000850 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM778.SHGJ.294" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1000850 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000854 ; owl:annotatedTarget obo:CL_1000504 . [] oboInOwl:hasDbXref "PMID:34843404" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000854 ; owl:annotatedTarget "A blood vessel cell that is part of a kidney." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000891 ; owl:annotatedTarget obo:CL_1000854 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000891 ; owl:annotatedTarget "Any kidney blood vessel cell that is part of some kidney arterial blood vessel." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000893 ; owl:annotatedTarget obo:CL_1000854 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000893 ; owl:annotatedTarget "Any kidney blood vessel cell that is part of some renal vein." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000909 ; owl:annotatedTarget obo:CL_1000494 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000909 ; owl:annotatedTarget "Any nephron tubule epithelial cell that is part of some loop of Henle." . _:genid15717 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006855 ] ) ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_2001013 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000979 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000979 ; owl:annotatedTarget obo:CL_1000601 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000979 ; owl:annotatedTarget "Any smooth muscle cell that is part of some muscular coat of ureter." . [] oboInOwl:hasDbXref "DOI:10.1016/j.biocel.2010.05.015", "DOI:10.1016/j.yexcr.2012.02.032", "DOI:10.1111/j.1523-1755.2005.00260.x", "DOI:10.2337/diacare.28.1.164", "DOI:10.3389/fphys.2021.689083" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1001005 ; owl:annotatedTarget """The glomerular capillary endothelial cell comprises an intrinsic component of the glomerulus in the kidney. Glomeruli contain a network of capillaries where the first step of blood filtration takes place, with glomerular capillary endothelial cells acting as an integral part of this process. Unlike regular endothelial cells that line the vasculature, unique fenestrations (openings) characterize these cells, allowing for enhanced permeability and filtration efficacy. Together with the glomerular basement membrane and podocytes, the glomerular endothelial cells form the glomerular filtration barrier, which is responsible for blood filtration and therefore critical for removal of waste products, such as urea and creatinine, and excess substances, such as glucose and ions, from the bloodstream. The glomerular capillary endothelial cells' fenestrations permit the free flow of a variety of particles, barring larger, negatively charged proteins like serum albumin, enabling the formation of an ultrafiltrate. This ultrafiltrate is the primitive form of urine, which then passes through the proximal tubule for further processing and ultimately helps maintain systemic fluid and electrolyte balance. Moreover, the glomerular capillary endothelial cells are also believed to play a crucial role in renal pathologies. Any compromise to their structural integrity or functional performance can lead to kidney diseases, including but not limited to, diabetic nephropathy and glomerulonephritis. For instance, in diabetes, persistent hyperglycemia can injure these cells, leading to a compromised glomerular filtration barrier and proteinuria, indicating the loss of proteins in the urine. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "glomerular capillary endothelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1001005 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1001005" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM778.SHGJ.294" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1001005 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001006 ; owl:annotatedTarget obo:CL_1000891 . [] oboInOwl:hasDbXref "PMID:16990493", "PMID:22733355", "PMID:24066938", "PMID:25834230" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001006 ; owl:annotatedTarget "An endothelial cell which is part of the afferent arteriole in the kidney. This cell is responsible for maintaining renal blood flow and glomerular filtration rate." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20054144", "PMID:29463737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000322 ; owl:annotatedTarget "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." . [] oboInOwl:hasDbXref "DOI:10.1007/s00424-012-1126-7", "DOI:10.1152/ajpregu.00332.2006", "DOI:10.1152/physrev.00042.2012", "DOI:10.2174/15701611113116660149" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1001006 ; owl:annotatedTarget """Kidney afferent arteriole cells are specialized cell types found in the renal vasculature, specifically in the afferent arterioles which help in maintaining the renal blood flow and glomerular filtration rate. They are essential for the proper functioning of the kidneys, contributing to the regulation of blood pressure and fluid balance within the organism. Located before the glomerulus, a tiny, intricate network of capillaries within the nephron, these cells help control the expansion or contraction of the arteriole, thus regulating the pressure and flow of blood into the glomerulus. Functionally, kidney afferent arteriole cells are largely involved in responding to changes in blood volume and systemic blood pressure. They achieve this by modulating the diameter of the afferent arteriole through a process known as autoregulation. Autoregulation involves two primary mechanisms: the myogenic response and the tubuloglomerular feedback. The myogenic response is essentially the intrinsic ability of the vascular smooth muscle to respond to pressure changes, while the tubuloglomerular feedback is the process where the macula densa cells located near the glomerulus respond to changes in fluid delivery rates in the tubules, sending signals to afferent arterioles to constrict or dilate accordingly. These cells also have significant interaction with renin-containing juxtaglomerular cells, which are located in the wall of afferent arterioles. Juxtaglomerular cells secrete the enzyme renin in response to low blood pressure or sympathetic nerve activity, initiating the renin-angiotensin-aldosterone system cascade that ultimately helps retain sodium and water to increase blood volume and pressure. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "kidney afferent arteriole cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1001006 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1001006" . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001009 ; owl:annotatedTarget "Any kidney arterial blood vessel cell that is part of some renal efferent arteriole." . [] oboInOwl:hasDbXref "DOI:10.1152/ajpregu.2000.279.2.R629", "DOI:10.1152/physrev.00042.2012", "DOI:10.1159/000072054", "DOI:10.1161/01.HYP.29.1.222", "DOI:10.3748/wjg.v12.i34.5429" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1001009 ; owl:annotatedTarget """Kidney efferent arteriole cells are highly adaptable vascular cells that make up the efferent arterioles in the kidney. These units are integral components of the renal microcirculation system, conducting blood away from the glomeruli after filtration occurs. Efferent arterioles directly affect glomerular hydrostatic pressure and, subsequently, the rate of glomerular filtration. They are the downstream channels that ensure the effective transportation of blood to the peritubular capillaries and vasa recta, critical for maintaining fluid balance and electrolyte homeostasis. Kidney efferent arteriole cells are exceptional in their ability to perform autoregulation—a critical dynamic control of intrarenal blood flow ensuring stable glomerular filtration rates. This is primarily achieved via myogenic and tubuloglomerular feedback mechanisms, where the cells respond to changes in pressure and the concentration of sodium chloride in the tubular fluid, and constrict or dilate depending on the detected changes. Cells associated with the efferent arteriole also respond to several systemic influences. Through complex intracellular signaling pathways, they respond to fluctuations in hormones (like angiotensin II and endothelin) and several other mediators such as nitric oxide and prostaglandins. Their adaptive capability helps maintain homeostasis and ensures the entire system's optimal performance under various physiological conditions. Dysfunctions in kidney efferent arteriole cells can lead to severe pathologies like hypertension and chronic kidney disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "kidney efferent arteriole cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1001009 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1001009" . [] oboInOwl:hasDbXref "PMID:32491474" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000322 ; owl:annotatedTarget "pneumocyte" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001016 ; owl:annotatedTarget obo:CL_1000909 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001016 ; owl:annotatedTarget "Any kidney loop of Henle epithelial cell that is part of some ascending limb of loop of Henle." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001021 ; owl:annotatedTarget obo:CL_1000909 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001021 ; owl:annotatedTarget "Any kidney loop of Henle epithelial cell that is part of some descending limb of loop of Henle." . [] oboInOwl:hasDbXref "DOI:10.1007/s00360-018-1164-3", "DOI:10.1146/annurev-physiol-021113-170350", "DOI:10.1152/advan.00227.2022" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1001021 ; owl:annotatedTarget """The kidney loop of Henle descending limb epithelial cells are highly specialized cells that play a crucial role in maintaining the body's salt and water balance. These cells line the descending limb of the loop of Henle, which is a portion of the renal tubule located in the kidneys, an organ responsible for filtering waste products, ions and extra water from the blood and converting them into urine. However, the descending limb epithelial cells are specifically involved in the countercurrent multiplication system, a mechanism to concentrate urine that involves both active and passive transport processes. These cells are notably permeable to water but relatively impermeable to solutes, a characteristic that dramatically influences the osmotic gradient in the renal medulla. As filtrate initially descends down the loop of Henle, water gets drawn out due to the increasing osmotic gradient, thereby concentrating the filtrate. Additionally, these epithelial cells are exceptionally thin walled, allowing water to freely diffuse across the membrane. Furthermore, the kidney loop of Henle descending limb epithelial cells are inextricably linked to the functioning of numerous diuretic drugs, which work by blocking the reabsorption of water and certain electrolytes in the kidneys, leading to increased urine production to rid the body of excess fluids. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "kidney loop of Henle descending limb epithelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1001021 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1001021" . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000325 ; owl:annotatedTarget "A cell that is specialised to accumulate a particular substance(s)." . [] oboInOwl:hasDbXref "PMID:19129259" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001033 ; owl:annotatedTarget "An endothelial cell that is part of the peritubular capillary of the kidney. This cell is highly fenestrated and plays a vital role in the kidney's filtration process, enabling the exchange of materials between the blood and the renal tubules." . [] oboInOwl:hasDbXref "PMID:19129259" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_1001033 ; owl:annotatedTarget "Peritubular capillary endothelial cells feature fenestrations measuring 60-70 nm in diameter, each traversed by a thin diaphragm." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001036 ; owl:annotatedTarget obo:CL_1000504 . [] oboInOwl:hasDbXref "PMID:12529271", "PMID:24381184" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001036 ; owl:annotatedTarget "A cell that is part of a vasa recta." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000327 ; owl:annotatedTarget "ZFA:0009162" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001045 ; owl:annotatedTarget "Any kidney arterial blood vessel cell that is part of some renal cortex artery." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001052 ; owl:annotatedTarget obo:CL_1000893 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001052 ; owl:annotatedTarget "Any kidney venous blood vessel cell that is part of some renal cortex vein." . [] oboInOwl:hasDbXref "PMID:16990493", "PMID:22733355", "PMID:24066938", "PMID:25834230" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001096 ; owl:annotatedTarget "An endothelial cell that lines the interior surface of the afferent arteriole and maintains vascular tone. This cell responds to changing ion concentrations and blood pressure by releasing vasoactive substances, in order to regulate blood flow into the glomeruli, which is essential for glomerular filtration." . [] oboInOwl:hasDbXref "DOI:10.1046/j.0001-6772.2003.01205.x", "DOI:10.1093/ndt/gfl308" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1001096 ; owl:annotatedTarget """Kidney afferent arteriole endothelial cells are a specialized type of cell located within the kidneys, forming the inner lining of the afferent arterioles, which are responsible for delivering blood to the glomeruli - capillary networks responsible for filtration - from where the process of urine formation begins in the nephrons. The endothelial cells in the kidney afferent arterioles have a key function in regulating the blood flow and filtration. They have autocrine and paracrine signaling capabilities, meaning they can signal to themselves and other nearby cells. They produce nitric oxide, prostacyclin, and endothelin, which are powerful vasodilators and vasoconstrictors that regulate renal blood flow. These cells also engage in the mitigation of kidney injury and inflammation by promoting repair and regeneration, demonstrating the multifaceted roles these cells play in maintaining renal health. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "kidney afferent arteriole endothelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1001096 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1001096" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM778.SHGJ.294" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1001096 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" . [] oboInOwl:hasDbXref "PMID:16990493", "PMID:22733355", "PMID:24066938", "PMID:25834230" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001097 ; owl:annotatedTarget "A smooth muscle cell found in the wall of the afferent arteriole. This cell contracts and relaxes in response to changes in blood pressure, a process known as a myogenic response, to alter artery diameter and regulate blood flow into the glomeruli." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001099 ; owl:annotatedTarget "Any endothelial cell that is part of some renal efferent arteriole." . [] oboInOwl:hasDbXref "DOI:10.1016/j.semcdb.2014.08.002", "DOI:10.1016/j.semnephrol.2015.01.010", "DOI:10.1038/s41581-021-00411-9", "DOI:10.1681/ASN.2019111179" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1001099 ; owl:annotatedTarget """Kidney efferent arteriole endothelial cells constitute a vital component of the kidney's microvascular system. They are unique endothelial cells found lining the walls of efferent arterioles, which transport blood away from the glomeruli in the kidney. The primary responsibilities of the kidney efferent arteriole endothelial cells involve controling renal blood flow, regulating glomerular filtration rate (GFR), and managing perfusion pressure. They do this by contracting and relaxing, effectively narrowing and widening the arteriole's lumen thereby controling the volume and rate of blood flow to the peritubular capillaries and creating the pressure gradient necessary for filtration in the glomerulus. Furthermore, kidney efferent arteriole endothelial cells show a high degree of plasticity in response to pathophysiological stimuli and can undergo structural and functional changes based on local needs. In conditions like hypertension and diabetes, these cells can experience hypertrophy and endothelial dysfunction, contributing to the progression of renal disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "kidney efferent arteriole endothelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1001099 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1001099" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM778.SHGJ.294" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1001099 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001100 ; owl:annotatedTarget "Any smooth muscle cell that is part of some renal efferent arteriole." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001106 ; owl:annotatedTarget obo:CL_1001016 . [] oboInOwl:hasDbXref "PMID:25318757" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001106 ; owl:annotatedTarget "An epithelial cell that is part of some loop of Henle thick ascending limb. It is known in some mammalian species that this cell may express the Na+-K+-2Cl− cotransporter (NKCC2) apically." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM927.DQNW.448" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1001106 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM299.GSQS.249" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1001106 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-thick-ascending-loop-of-henle/v1.2/assets/2d-ftu-kidney-thick-ascending-loop-of-henle.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001107 ; owl:annotatedTarget obo:CL_1001016 . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM489.KLNJ.323" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1001107 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-ascending-thin-loop-of-henle/v1.2/assets/2d-ftu-kidney-ascending-thin-loop-of-henle.png" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM927.DQNW.448" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1001107 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000329 ; owl:annotatedTarget "Any cell that is capable of some oxygen transport." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001108 ; owl:annotatedTarget obo:CL_1000616 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000329 ; owl:annotatedTarget "ZFA:0009164" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001111 ; owl:annotatedTarget obo:CL_1001021 . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM979.XZTC.458" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1001111 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-descending-thin-loop-of-henle/v1.1/assets/2d-ftu-kidney-descending-thin-loop-of-henle.png" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM927.DQNW.448" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1001111 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000330 ; owl:annotatedTarget "Obsolete. Use PO:0000075 from Plant Ontology instead. An elongated living cell with unevenly thickened nonlignified primary walls." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000331 ; owl:annotatedTarget "Obsolete. Use PO:0000301 from Plant Ontology instead. A tracheary element of the xylem that has no perforations, as contrasted with a vessel member. May occur in primary and in secondary xylem. May have any kind of secondary wall thickening found in tracheary elements." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001126 ; owl:annotatedTarget obo:CL_1000617 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001126 ; owl:annotatedTarget obo:CL_1001036 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001126 ; owl:annotatedTarget "Any vasa recta cell that is part of some inner renal medulla vasa recta." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001127 ; owl:annotatedTarget obo:CL_1000616 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001127 ; owl:annotatedTarget obo:CL_1001036 . [] oboInOwl:hasDbXref "ISBN:0387987819" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000332 ; owl:annotatedTarget "OBSOLETE, use term from Plant Ontology. A cell formed after asymmetric division of root epidermal cell that does not give rise to a root hair." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001127 ; owl:annotatedTarget "Any vasa recta cell that is part of some outer renal medulla vasa recta." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001131 ; owl:annotatedTarget obo:CL_1001036 . [] oboInOwl:hasDbXref "DOI:10.1016/B978-0-323-35515-5.00009-9", "DOI:10.1053/j.ajkd.2005.01.008", "DOI:10.1081/jdi-100101958", "DOI:10.1111/apha.12026", "DOI:10.1152/ajpregu.00657.2002" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1001131 ; owl:annotatedTarget """The vasa recta ascending limb cells are specialized epithelial cells that are part of the vasa recta in the kidney, a crucial component of the renal medulla that functions as a counter-current exchanger to maintain the concentration gradient required for water reabsorption. These particular cells are located in the ascending limb of the vasa recta, which takes blood flow from the medulla back to the cortex. The primary function of vasa recta ascending limb cells is to preserve the renal medulla's hypertonicity, necessary for the kidney's urine concentration mechanism. Unlike the vasa recta descending limb cells, the venous-like epithelial cells of the ascending vasa recta are highly fenestrated and lack pericyte coverage, which facilitates water reuptake. As the blood flows through the ascending limb, it loses solutes and gains water, which is driven by the high solute concentration in the surrounding interstitium. This process acts in concert with cellular action in the descending limb and contributions from the so-called Loop of Henle, which helps with water and sodium chloride retrieval from the urine. In the context of normal physiological processes, the function of the vasa recta ascending limb cells is essential in maintaining the body's overall fluid balance, electrolyte concentration, and systemic blood pressure. Any dysfunction in these cells may lead to impaired urine concentration or dilution capability of the kidney, potentially resulting in conditions like diabetes insipidus or hyponatremia. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "PMID:20392798", "PMID:20392799", "PMID:26062876" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_1001131 ; owl:annotatedTarget "It is known in some mammalian species that this cell may express PV-1, a component of the fenestral diaphragm." . [] a owl:Axiom ; rdfs:label "vasa recta ascending limb cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1001131 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1001131" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM489.KLNJ.323" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1001131 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-ascending-thin-loop-of-henle/v1.2/assets/2d-ftu-kidney-ascending-thin-loop-of-henle.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001135 ; owl:annotatedTarget obo:CL_1001045 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001135 ; owl:annotatedTarget "Any kidney cortex artery cell that is part of some kidney arcuate artery." . [] oboInOwl:hasDbXref "doi:10.1016/j.stem.2015.02.017" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000333 ; owl:annotatedTarget "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001138 ; owl:annotatedTarget obo:CL_1001045 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001138 ; owl:annotatedTarget "Any kidney cortex artery cell that is part of some interlobular artery." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000333 ; owl:annotatedTarget "ZFA:0007086" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001142 ; owl:annotatedTarget obo:CL_1001052 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001142 ; owl:annotatedTarget "Any kidney cortex vein cell that is part of some kidney arcuate vein." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001145 ; owl:annotatedTarget obo:CL_1001052 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001145 ; owl:annotatedTarget "Any kidney cortex vein cell that is part of some renal interlobular vein." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:5025404" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000335 ; owl:annotatedTarget "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001209 ; owl:annotatedTarget obo:CL_1001126 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001209 ; owl:annotatedTarget obo:CL_1001131 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001209 ; owl:annotatedTarget "Any vasa recta ascending limb cell that is part of some inner medulla ascending vasa recta." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000335 ; owl:annotatedTarget "ZFA:0009166" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001210 ; owl:annotatedTarget obo:CL_1001127 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001210 ; owl:annotatedTarget obo:CL_1001131 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001210 ; owl:annotatedTarget "Any vasa recta ascending limb cell that is part of some outer medulla ascending vasa recta." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001213 ; owl:annotatedTarget "Any endothelial cell that is part of some kidney arcuate artery." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001214 ; owl:annotatedTarget "Any smooth muscle cell that is part of some kidney arcuate artery." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001216 ; owl:annotatedTarget "Any endothelial cell that is part of some interlobular artery." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001217 ; owl:annotatedTarget "Any smooth muscle cell that is part of some interlobular artery." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001220 ; owl:annotatedTarget "Any endothelial cell that is part of some kidney arcuate vein." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001221 ; owl:annotatedTarget "Any smooth muscle cell that is part of some kidney arcuate vein." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001223 ; owl:annotatedTarget "Any endothelial cell that is part of some renal interlobular vein." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001224 ; owl:annotatedTarget "Any smooth muscle cell that is part of some renal interlobular vein." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001285 ; owl:annotatedTarget obo:CL_1001036 . [] oboInOwl:hasDbXref "DOI:10.1053/j.ajkd.2005.01.008", "DOI:10.1081/jdi-100101958", "DOI:10.1111/apha.12026#apha12026-bib-0039", "DOI:10.1152/ajpregu.00657.2002" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1001285 ; owl:annotatedTarget """Vasa recta descending limb cells are specialized epithelial cells found in the vasa recta, a network of blood vessels in the renal medulla. These cells line the interior surface of the descending limb of the vasa recta and play a crucial role in the filtering and regulation of substances within the blood. In contrast to vasa recta ascending limb cells, the arterial-like epithelial cells of the descending vasa recta are non-fenestrated and covered by a pericyte layer that regulates the medullary blood flow. They help keeping the body’s fluid and electrolyte balance in check through a process known as countercurrent exchange system, in which the cells of the descending limb are permeable to water but relatively impermeable to solutes, such as sodium and urea. As the blood descends into the medulla along its descending limb, water passively diffuses out of the vasa recta, concentrating the blood in solutes. In addition to their central role in water and solute exchange, these cells contribute to maintaining the medullary osmotic gradient, a critical function to concentrate urine. The osmotic gradient is created by the counterflow of water and solutes between the descending and ascending limbs of the vasa recta and the adjacent Loop of Henle. The selective permeability of the descending limb cells allows them to maintain this gradient, which in turn helps to conserve water, a vital role in the overall function of the renal system. Thus, vasa recta descending limb cells have a significant function in renal physiology, particularly in osmoregulation and fluid balance. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "PMID:20392798", "PMID:20392799", "PMID:26062876" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_1001285 ; owl:annotatedTarget "It is known in some mammalian species that this cell may express the urea transporter B." . [] a owl:Axiom ; rdfs:label "vasa recta descending limb cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1001285 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1001285" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM979.XZTC.458" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_1001285 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-descending-thin-loop-of-henle/v1.1/assets/2d-ftu-kidney-descending-thin-loop-of-henle.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001286 ; owl:annotatedTarget obo:CL_1001126 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001286 ; owl:annotatedTarget obo:CL_1001285 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001286 ; owl:annotatedTarget "Any vasa recta descending limb cell that is part of some inner medulla descending vasa recta." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000005 ; owl:annotatedTarget "Any fibroblast that is derived from the neural crest." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.britannica.com/EBchecked/topic/6405/adrenal-gland" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000336 ; owl:annotatedTarget "A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001287 ; owl:annotatedTarget obo:CL_1001127 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001287 ; owl:annotatedTarget obo:CL_1001285 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001287 ; owl:annotatedTarget "Any vasa recta descending limb cell that is part of some outer medulla descending vasa recta." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000336 ; owl:annotatedTarget "ZFA:0009167" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001318 ; owl:annotatedTarget obo:CL_0000669 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001319 ; owl:annotatedTarget "Any cell that is part of some urinary bladder." . [] oboInOwl:hasDbXref "FMA:69262" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000336 ; owl:annotatedTarget "medullary chromaffin cell of adrenal gland" . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001320 ; owl:annotatedTarget "Any cell that is part of some urethra." . [] oboInOwl:hasDbXref "doi:10.1038/s41385-022-00565-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001428 ; owl:annotatedTarget "A urothelial cell that is part of the urothelium of the urinary bladder." . [] oboInOwl:hasDbXref "DOI:10.1038/nrurol.2011.144", "DOI:10.1038/nrurol.2016.13", "DOI:10.1038/s41579-020-0324-0", "DOI:10.1038/s41585-020-0350-8", "DOI:10.1080/03008880410015165" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1001428 ; owl:annotatedTarget """Bladder urothelial cells form the urothelium in the bladder - a specific type of epithelial tissue that constitutes the inner lining of the bladder and other parts of the urinary tract including the renal pelvis, ureters and urethra. These unique cells are specialized to withstand the highly variable and sometimes harsh conditions present in the urinary system. Their key function is maintaining the barrier integrity of the urinary tract even when exposed to high volumes of urine and its solutes, and they play a crucial role in protecting underlying tissues from damage and infection. The bladder urothelial cells exhibit a remarkable spectrum of phenotypic versatility and have an extraordinary capacity to stretch and retract based on the degree of bladder filling and emptying. In their relaxed state, these cells appear large and cuboidal, but upon stretching, they become thinner and exhibit a squamous cell-like appearance. This distinctive feature enables them to adjust to the changes in the urinary bladder volume while remaining impermeable to urinary solutes, thereby preventing a potential toxicity to the bladder wall and infiltration into the bloodstream. Apart from their barrier function, bladder urothelial cells also express a number of sensor molecules or respond to thermal, mechanical and chemical stimuli and can release signaling molecules, thereby playing a key role in sensory mechanisms that communicate vital information about the bladder's mechanical state to the nervous system. This communication helps regulate the micturition cycle and maintain urinary continence. Recent studies have also indicated that these cells may play a role in immune responses, highlighting their importance in bladder physiology. Altered proliferation and differentiation of bladder urothelial cells are implicated in various diseases and conditions such as bladder cancer, interstitial cystitis, and urinary tract infections. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "bladder urothelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1001428 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1001428" . [] oboInOwl:hasDbXref "PMID:23589830", "PMID:36180582" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001430 ; owl:annotatedTarget "A urothelial cell that is part of the urethra urothelium. This cell plays a crucial role in maintaining the urethral barrier function, protecting against toxic substances in urine, sensing environmental changes, and defending against pathogen entry." . [] oboInOwl:hasDbXref "DOI:10.1038/nrurol.2016.13", "DOI:10.1038/s41385-022-00565-0", "DOI:10.1152/physrev.00030.2012", "DOI:10.1152/physrev.00041.2019" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1001430 ; owl:annotatedTarget """Urethra urothelial cells are highly specialized epithelial cells in the urethra, which is a tubelike structure that carries urine from the bladder to the external urethral orifice. Urothelial cells form the urothelium – a stratified, transitional epithelium lining the bladder, ureters, renal pelvis and urethra. These cells are highly adapted to their specific environment and maintain the crucial function of sustaining the urinary tract's core roles, primarily to transit and store urine without auto-corrosion or pathogen proliferation. Within the urethra urothelial cells are primarily found in proximal two-thirds of the urethra, while the distal third is lined by stratified squamous epithelial cells. The urothelial cells are renowned for their remarkable impermeability and ability to stretch and recoil during the various stages of urine filling and emptying. They form a tight barrier that prevents reabsorption of harmful byproducts and toxic substances present in the urine, guarding the deeper tissues and bloodstream against potential damage. This is largely attributed to specialized junctions, namely zonulae occludentes or tight junctions, in the umbrella cell layer (one of three layers of the urothelium) that seal the intercellular space between adjacent cells. Together with the urothelial plaque (an apical membrane plaque comprised of uroplakin proteins covering the umbrella cells at the luminal surface), the junctional complexes form a very effective permeability barrier that regulates the passage of water and ion from urine to the underlying tissue. A noteworthy feature of urothelial cells is their regulatory and sensory roles involving communication with the underlying layers about the filling and emptying status of the urinary tract. The cells also manage a fine balance between proliferation and differentiation, with the basal cells providing a ready pool of cells to replace the superficial layer when damaged. Their remarkable ability for regeneration and turnover, and their response to signals for repair underpins the durability and functionality of the urothelial tract. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "urethra urothelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1001430 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1001430" . [] oboInOwl:hasDbXref "PMID:1295739" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000338 ; owl:annotatedTarget "A neural precursor of the central nervous system." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001431 ; owl:annotatedTarget obo:CL_0005009 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001431 ; owl:annotatedTarget "Any renal principal cell that is part of some collecting duct of renal tubule." . [] oboInOwl:hasDbXref "DOI:10.1007/s11906-015-0538-0", "DOI:10.1016/B978-0-12-386456-7.05402-2", "DOI:10.1016/j.biocel.2022.106261", "DOI:10.1073/pnas.1710964114" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1001431 ; owl:annotatedTarget """The kidney collecting duct principal cell is a highly specialized type of cell found in the late distal convoluted tubule and collecting duct of the kidney's nephron. Principal cells are located at the final segments of the renal tubules, where they play a pivotal role in key homeostatic processes. One of their fundamental functions of kidney collecting duct principal cells is the regulation of water reabsorption, which is mediated by aquaporins (water channel proteins). Antidiuretic hormones, such as vasopressin, can stimulate the redistribution of these water channels from an intracellular pools to the apical plasma membrane of the principal cell; translocation of aquaporin (specifically, AQP2) is associated with an increase of osmotic water permeability. The water reabsorption affects the concentration of the final urine; these cells are therefore directly involved in the maintenance of the body's fluid balance. Kidney collecting duct principal cells also participate in sodium and potassium ions regulation. They reabsorb sodium ions from the tubular fluid back into the bloodstream, a process facilitated by the action of aldosterone, a hormone released by the adrenal glands. Similarly, the principal cells secrete potassium ions into the tubular fluid in response to aldosterone, contributing to the regulation of potassium levels in the body. Impaired function of cells can lead to various renal diseases and disorders, highlighting the vital role of kidney collecting duct principal cells in the body's homeostatic processes. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "kidney collecting duct principal cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1001431 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1001431" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000338 ; owl:annotatedTarget "FBbt:00005146" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001432 ; owl:annotatedTarget obo:CL_0005010 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001432 ; owl:annotatedTarget "Any renal intercalated cell that is part of some collecting duct of renal tubule." . [] oboInOwl:hasDbXref "DOI:10.1007/978-3-211-99390-3_106", "DOI:10.1152/physiol.00008.2011", "DOI:10.1152/physrev.00011.2019", "DOI:10.2215/CJN.08880914", "DOI:10.3390/diseases2020071" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1001432 ; owl:annotatedTarget """The kidney collecting duct intercalated cell, otherwise referred to simply as the intercalated cell, is a specialized epithelial cell type primarily found in the kidney's collecting duct system. It is among the main cells that line this final component of the nephron, crucial in the physiological system that maintains acid-base homeostasis. This unique cell type comes in mainly three subtypes as per the localization of their proton pumps: type A, type B, and non-A, non-B cells. Each subtype plays different roles in regulating acid-base balance and electrolyte homeostasis in the body under varying physiological conditions. Type A intercalated cells reabsorb bicarbonate and secrete protons into urine, leading to the production of acidic urine. These cells are typically prevalent on the renal cortex and function particularly in states of metabolic acidosis or potassium depletion. On the other hand, type B intercalated cells secrete bicarbonate and reabsorb protons; thus, they are crucial in alkaline urine production and potassium conservation. These cells are essential to counter metabolic alkalosis or situations of potassium surplus. The non-A, non-B cells have the characteristic features of both type A and B cells, but play a prominent role under conditions of chronically elevated aldosterone and angiotensin II levels. Through their differentiated roles, intercalated cells also facilitate the reabsorption of sodium and chloride ions, and water to maintain osmolarity. These cells' activity is finely regulated by hormonal signals like aldosterone, angiotensin II, vasopressin, and the parathyroid hormone. Intercalated cell activity can undergo a significant transformation under pathological conditions, and their dysregulation is associated with diseases such as distal renal tubular acidosis, hypertension, and chronic kidney disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "kidney collecting duct intercalated cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1001432 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1001432" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000339 ; owl:annotatedTarget "An early neural cell developing from the early ependymal cell of the neural tube." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001433 ; owl:annotatedTarget "An epithelial cell of the exocrine pancreas." . [] oboInOwl:hasDbXref "PMID:18603310" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001434 ; owl:annotatedTarget "A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons" . [] oboInOwl:hasDbXref "MP:0009943" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001435 ; owl:annotatedTarget "The small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000339 ; owl:annotatedTarget "ZFA:0009169" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "NIFEXT:122" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1001435 ; owl:annotatedTarget "glomerular layer cell" . [] oboInOwl:hasDbXref "NIFEXT:122" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1001435 ; owl:annotatedTarget "olfactory bulb (accessory) glomerular layer cell" . [] oboInOwl:hasDbXref "NIFEXT:122" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1001435 ; owl:annotatedTarget "olfactory bulb glomerular layer cell" . [] oboInOwl:hasDbXref "MP:0009943" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1001435 ; owl:annotatedTarget "olfactory bulb glomerularal cell" . [] oboInOwl:hasDbXref "MP:0000977" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001436 ; owl:annotatedTarget "The subcutaneous mechanoreceptors that innervate tylotrich hair follicles." . [] oboInOwl:hasDbXref "MP:0000979" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001437 ; owl:annotatedTarget "The subcutaneous mechanoreceptors that innervate vellus hairs." . [] oboInOwl:hasDbXref "doi:10.1002/glia.21162" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000340 ; owl:annotatedTarget "A precursor of the central nervous system that gives rise to glial cells only." . [] oboInOwl:hasDbXref "MP:0004297" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001451 ; owl:annotatedTarget "A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord." . [] oboInOwl:hasDbXref "MP:0004297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1001451 ; owl:annotatedTarget "proprioceptive neuron" . [] oboInOwl:hasDbXref "MP:0008462", "doi:10.1073/pnas.242428599" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001474 ; owl:annotatedTarget "An inhibitory, GABAergic projection neuron in the striatum that integrates glutamatergic signals arising from the cerebral cortex and thalamus." . [] oboInOwl:hasDbXref "doi:10.1073/pnas.242428599" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1001474 ; owl:annotatedTarget "gamma-aminobutyric acid (GABA)ergic spiny projection neuron" . [] oboInOwl:hasDbXref "doi:10.1073/pnas.242428599" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1001474 ; owl:annotatedTarget "gamma-aminobutyric acid ergic spiny projection neuron" . [] oboInOwl:hasDbXref "GO:0021773" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1001474 ; owl:annotatedTarget "striatal medium spiny neuron" . [] oboInOwl:hasDbXref "BTO:0004778" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001474 ; owl:annotatedTarget "medium-sized densely spiny neuron" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000340 ; owl:annotatedTarget "FBbt:00005145" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "MP:0009954" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001502 ; owl:annotatedTarget "The large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex." . [] oboInOwl:hasDbXref "MP:0009955" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001503 ; owl:annotatedTarget "The principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala." . [] oboInOwl:hasDbXref "MP:0010125" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001505 ; owl:annotatedTarget "The secretory neurons of the paraventricular nucleus that synthesize and secrete vasopressin, corticotropin-releasing factor (CRF) and thyrotropin-releasing hormone (TRH) into blood vessels in the hypothalamo-pituitary portal system." . [] oboInOwl:hasDbXref "MP:0010385" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001509 ; owl:annotatedTarget "The neurons that utilize glycine as a neurotransmitter." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_1001509 ; owl:annotatedTarget "FBbt:00048032" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_1001509 ; owl:annotatedTarget "ZFA:0009396" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000342 ; owl:annotatedTarget "Any animal cell containing pigment granules." . [] oboInOwl:hasDbXref "MP:0010802" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001516 ; owl:annotatedTarget "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract." . [] oboInOwl:hasDbXref "DOI:10.1016/j.coph.2013.09.008", "DOI:10.1038/mi.2017.73", "DOI:10.1038/s41574-019-0168-8", "DOI:10.1111/j.1365-2613.2011.00767.x", "DOI:10.1146/annurev-physiol-021115-105439" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1001516 ; owl:annotatedTarget """Intestinal enteroendocrine cells are a highly specialized cell type found within the gastrointestinal epithelium. They account for approximately 1% of the intestinal epithelial cells in what is known as the largest endocrine organ in the human body. Intestinal enteroendocrine cells exhibit an exceptional diversity, both in terms of their secretory products and their distribution along the intestines, varying from the small intestine to the colon. The primary function of intestinal enteroendocrine cells is to maintain gut physiology and homeostasis. They are known for their hormone production and are the source of numerous bioactive molecules including somatostatin, serotonin, cholecystokinin, glucose-dependent insulinotropic peptide, motilin, neurotensin, and others. These hormones and neuropeptides act in autocrine, paracrine, or endocrine signaling, impacting various functions including intestinal motility, secretion, nutrient absorption, and gut barrier functions. Intestinal enteroendocrine cells also serve as the body's frontline of defense, playing an integral role in surveillance against lumen-occurring hazards including pathogen attack. Enteroendocrine cells are divided into ‘closed type’ and ‘open type’. Closed type cells are located close to the basal membrane and do not reach the lumen of the gut. In contrast, the apical side of the open-type intestinal enteroendocrine cells is directly exposed to luminal contents and thus can recognize bacterial metabolites and dietary nutrients. In response, these cells can modulate the immune system responses and thereby function as a key communicator between the gut microbiota and the host. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "intestinal enteroendocrine cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1001516 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1001516" . [] oboInOwl:hasDbXref "MP:0010803" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001517 ; owl:annotatedTarget "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000342 ; owl:annotatedTarget "ZFA:0009170" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "MP:0011679" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001561 ; owl:annotatedTarget "Chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals." . [] oboInOwl:hasDbXref "MP:0011691" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001566 ; owl:annotatedTarget "OBSOLETE. A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and club cells in response to lung injury." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001567 ; owl:annotatedTarget "Any endothelial cell of vascular tree that is part of some lung." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001568 ; owl:annotatedTarget "Any endothelial cell of vascular tree that is part of some pulmonary artery." . [] oboInOwl:hasDbXref "BTO:0001141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001568 ; owl:annotatedTarget "PAEC cell" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001569 ; owl:annotatedTarget "An interneuron with a soma found in the hippocampus." . [] oboInOwl:hasDbXref "GOC:pr", "PMID:19342486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001571 ; owl:annotatedTarget "A pyramidal neuron with a soma found in the hippocampus." . [] oboInOwl:hasDbXref "NIFSTD:sao131261273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_1001571 ; owl:annotatedTarget "hippocampus (CA) pyramidal cell" . [] oboInOwl:hasDbXref "NIFSTD:sao131261273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_1001571 ; owl:annotatedTarget "hippocampus (CA) pyramidal neuron" . [] oboInOwl:hasDbXref "NPX:PDR", "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001572 ; owl:annotatedTarget "A vascular endothelial cell found in colon blood vessels." . [] oboInOwl:hasDbXref "CALOHA:TS-2397" ; oboInOwl:hasSynonymType obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001572 ; owl:annotatedTarget "colon endothelial cells" . [] oboInOwl:hasDbXref "CALOHA:TS-2397" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001572 ; owl:annotatedTarget "colonic endothelial cell" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001573 ; owl:annotatedTarget "Cell of the nasopharyngeal epithelium." . [] oboInOwl:hasDbXref "CALOHA:TS-2398" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001573 ; owl:annotatedTarget "nasopharynx respiratory epithelial cells" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001575 ; owl:annotatedTarget "Squamous cell of uterine cervix epithelium." . [] oboInOwl:hasDbXref "CALOHA:TS-1251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001575 ; owl:annotatedTarget "cervix squamous cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001575 ; owl:annotatedTarget "cervix squamous epithelial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001575 ; owl:annotatedTarget "cervix, uterine squamous epithelial cells" . [] oboInOwl:hasDbXref "CALOHA:TS-1251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001575 ; owl:annotatedTarget "uterine cervix squamous epithelial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001575 ; owl:annotatedTarget "uterine cervix squamous epithelial cells" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000343 ; owl:annotatedTarget obo:CL_0000342 . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001576 ; owl:annotatedTarget "Squamous cell of oral epithelium." . [] oboInOwl:hasDbXref "CALOHA:TS-1252" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001576 ; owl:annotatedTarget "oral cavity mucosa squamous cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1252" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001576 ; owl:annotatedTarget "oral cavity mucosa squamous epithelial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1252" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001576 ; owl:annotatedTarget "oral mucosa squamous epithelial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1252" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001576 ; owl:annotatedTarget "oral mucosa squamous epithelial cells" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000343 ; owl:annotatedTarget "A pigment cell that is capable of detecting light stimulus that is involved in visual perception." . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001577 ; owl:annotatedTarget "Squamous cell of tonsil epithelium." . [] oboInOwl:hasDbXref "CALOHA:TS-1253" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001577 ; owl:annotatedTarget "tonsil squamous epithelial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1253" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001577 ; owl:annotatedTarget "tonsil squamous epithelial cells" . [] oboInOwl:hasDbXref "CALOHA:TS-1253" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001577 ; owl:annotatedTarget "tonsillar squamous cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1253" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001577 ; owl:annotatedTarget "tonsillar squamous epithelial cell" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000343 ; owl:annotatedTarget "ZFA:0009171" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001578 ; owl:annotatedTarget "Squamous cell of vaginal epithelium." . [] oboInOwl:hasDbXref "CALOHA:TS-1254" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001578 ; owl:annotatedTarget "vagina squamous epithelial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1254" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001578 ; owl:annotatedTarget "vagina squamous epithelial cells" . [] oboInOwl:hasDbXref "CALOHA:TS-1254" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001578 ; owl:annotatedTarget "vaginal squamous cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1254" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001578 ; owl:annotatedTarget "vaginal squamous epithelial cell" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001579 ; owl:annotatedTarget "Glial cell of cerebral cortex." . [] oboInOwl:hasDbXref "CALOHA:TS-1256" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001579 ; owl:annotatedTarget "brain cortex glial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1256" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001579 ; owl:annotatedTarget "cerebral cortex glial cells" . [] oboInOwl:hasDbXref "CALOHA:TS-1256" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001579 ; owl:annotatedTarget "cerebrum cortex glial cell" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001580 ; owl:annotatedTarget "A glial cell that is part of the hippocampus." . [] oboInOwl:hasDbXref "CALOHA:TS-1257" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1001580 ; owl:annotatedTarget "hippocampus glial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1257" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1001580 ; owl:annotatedTarget "hippocampus neuroglial cell" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000345 ; owl:annotatedTarget "A mesenchymal cell that is part of a small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp." . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001581 ; owl:annotatedTarget "Glial cell of lateral ventricle." . [] oboInOwl:hasDbXref "CALOHA:TS-1258" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001581 ; owl:annotatedTarget "lateral ventricle glial cells" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001582 ; owl:annotatedTarget "Neuron of lateral ventricle." . [] oboInOwl:hasDbXref "CALOHA:TS-1261" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001582 ; owl:annotatedTarget "lateral ventricle neural cell" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000345 ; owl:annotatedTarget "ZFA:0009173" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "CALOHA:TS-1261" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001582 ; owl:annotatedTarget "lateral ventricle neuronal cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1261" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001582 ; owl:annotatedTarget "lateral ventricle neuronal cells" . [] oboInOwl:hasDbXref "HPA:Breast" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001583 ; owl:annotatedTarget "OBSOLETE: Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma." . [] oboInOwl:hasDbXref "CALOHA:TS-2377" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001583 ; owl:annotatedTarget "breast adipocytes" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001585 ; owl:annotatedTarget "Glandular cell of appendix epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." . [] oboInOwl:hasDbXref "CALOHA:TS-1271" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001585 ; owl:annotatedTarget "appendix glandular cells" . [] oboInOwl:hasDbXref "CALOHA:TS-1271" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001585 ; owl:annotatedTarget "caecal appendix glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1271" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001585 ; owl:annotatedTarget "cecal appendix glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1271" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001585 ; owl:annotatedTarget "vermiform appendix glandular cell" . [] oboInOwl:hasDbXref "HPA:HPA", "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001586 ; owl:annotatedTarget "Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts." . [] oboInOwl:hasDbXref "CALOHA:TS-1272" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001586 ; owl:annotatedTarget "breast glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1272" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001586 ; owl:annotatedTarget "breast glandular cells" . [] oboInOwl:hasDbXref "CALOHA:TS-1272" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001586 ; owl:annotatedTarget "mammary glandular cell" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001587 ; owl:annotatedTarget "Glandular cell of uterine cervix epithelium." . [] oboInOwl:hasDbXref "CALOHA:TS-1273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001587 ; owl:annotatedTarget "cervix glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001587 ; owl:annotatedTarget "cervix, uterine glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001587 ; owl:annotatedTarget "cervix, uterine glandular cells" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001588 ; owl:annotatedTarget "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." . [] oboInOwl:hasDbXref "CALOHA:TS-1274" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001588 ; owl:annotatedTarget "colon glandular cells" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001589 ; owl:annotatedTarget "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell." . [] oboInOwl:hasDbXref "CALOHA:TS-1275" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_1001589 ; owl:annotatedTarget "duodenum glandular cells" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001590 ; owl:annotatedTarget "Glandular cell of epididymal epithelium." . [] oboInOwl:hasDbXref "CALOHA:TS-1276" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001590 ; owl:annotatedTarget "epididymal glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1276" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001590 ; owl:annotatedTarget "epididymis glandular cell" . [] oboInOwl:hasDbXref "HPA:HPA", "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001591 ; owl:annotatedTarget "Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells." . [] oboInOwl:hasDbXref "CALOHA:TS-1277" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001591 ; owl:annotatedTarget "fallopian tube glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1277" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001591 ; owl:annotatedTarget "fallopian tube glandular cells" . [] oboInOwl:hasDbXref "CALOHA:TS-1277" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001591 ; owl:annotatedTarget "uterine tube glandular cell" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D013234" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000034 ; owl:annotatedTarget "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001592 ; owl:annotatedTarget "Glandular cell of gallbladder epithelium." . [] oboInOwl:hasDbXref "FMA:7202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1001592 ; owl:annotatedTarget "gall bladder glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1278" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001592 ; owl:annotatedTarget "gall bladder glandular cells" . [] oboInOwl:hasDbXref "CALOHA:TS-1278" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001592 ; owl:annotatedTarget "gallbladder glandular cells" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000346 ; owl:annotatedTarget obo:CL_0000134 . [] oboInOwl:hasDbXref "HPA:HPA", "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001593 ; owl:annotatedTarget "Glandular (secretory) cell of parathyroid epithelium." . [] oboInOwl:hasDbXref "CALOHA:TS-1279" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001593 ; owl:annotatedTarget "parathyroid gland glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1279" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001593 ; owl:annotatedTarget "parathyroid gland glandular cells" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:9893172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000346 ; owl:annotatedTarget "A specialized mesenchymal cell that resides in the dermal papilla located at the bottom of hair follicles. This cell plays a pivotal roles in hair formation, growth, and cycling." . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001595 ; owl:annotatedTarget "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells." . [] oboInOwl:hasDbXref "CALOHA:TS-1281" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001595 ; owl:annotatedTarget "rectal glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1281" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001595 ; owl:annotatedTarget "rectum glandular cells" . [] oboInOwl:hasDbXref "HPA:HPA", "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001596 ; owl:annotatedTarget "Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts." . [] oboInOwl:hasDbXref "CALOHA:TS-1282" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001596 ; owl:annotatedTarget "salivary gland glandular cells" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001597 ; owl:annotatedTarget "Glandular cell of seminal vesicle epithelium." . [] oboInOwl:hasDbXref "DOI:10.1007/978-3-030-32300-4_26", "DOI:10.1007/s00265-006-0178-0", "DOI:10.1111/j.1439-0272.1992.tb02636.x", "https://www.ncbi.nlm.nih.gov/books/NBK499854/", "https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/seminal-vesicle" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1001597 ; owl:annotatedTarget """Seminal vesicle glandular cells belong to a specialized group of epithelial cells that form the internal lining of the seminal vesicles, a pair of male reproductive organs. These cells are located within the complex tubuloalveolar glands that make up the seminal vesicles and are known for their unique pseudostratified columnar epithelium structure. The primary function of these cells is the secretion of a variety of substances that ultimately constitute around 70% of the fluid volume of semen. Seminal cells produce a high-fructose fluid that serves as an energy source for the spermatozoa and promotes their motility. They also secrete other essential substances like proteins, enzymes, vitamin C, prostaglandins, and various other compounds. Collectively, these substances help in the nourishment, protection, and transportation of the spermatozoa throughout the male reproductive system and during the ejaculation process. Secondary to the production of seminal fluid, the seminal vesicle glandular cells also play a role in the contraction of the seminal vesicles during ejaculation. The contraction of these glands, induced by sympathetic nerves, ensures the efficient propulsion of the seminal fluid mixed with spermatozoa into the ejaculatory ducts and subsequently to the urethra. Notably, any malfunction or pathological condition affecting these cells can impact male fertility, emphasizing the importance of understanding the intricate functions of seminal vesicle glandular cells in maintaining the healthy physiological function of male reproduction. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "CALOHA:TS-1283" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001597 ; owl:annotatedTarget "seminal vesicle glandular cells" . [] a owl:Axiom ; rdfs:label "seminal vesicle glandular cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1001597 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1001597" . [] oboInOwl:hasDbXref "NCI_Thesaurus:Small_Intestinal_Glandular_Cell", "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001598 ; owl:annotatedTarget "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ." . [] oboInOwl:hasDbXref "CALOHA:TS-1286" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_1001598 ; owl:annotatedTarget "small intestinal glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1286" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001598 ; owl:annotatedTarget "small bowel glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1286" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001598 ; owl:annotatedTarget "small intestine glandular cells" . [] oboInOwl:hasDbXref "HPA:HPA", "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001599 ; owl:annotatedTarget "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts." . [] oboInOwl:hasDbXref "CALOHA:TS-1242" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001599 ; owl:annotatedTarget "exocrine pancreas glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1242" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001599 ; owl:annotatedTarget "pancreas exocrine glandular cells" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001601 ; owl:annotatedTarget "Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens." . [] oboInOwl:hasDbXref "CALOHA:TS-2177" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001601 ; owl:annotatedTarget "adrenal gland glandular cells" . [] oboInOwl:hasDbXref "CALOHA:TS-2177" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001601 ; owl:annotatedTarget "adrenal glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-2177" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001601 ; owl:annotatedTarget "suprarenal gland glandular cell" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001602 ; owl:annotatedTarget "A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex." . [] oboInOwl:hasDbXref "DOI:10.1038/nbt.2247", "DOI:10.1038/nrn1824", "DOI:10.1177/0271678X156179", "DOI:10.1186/s12987-020-00230-3", "DOI:10.3389/fnins.2023.1047778" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1001602 ; owl:annotatedTarget """Cerebral cortex endothelial cells are unique endothelial cells responsible for the formation and regulation of the blood-brain barrier (BBB), a specialized structure that separates the circulating blood from the cerebral neural tissue. These cells line the inner surface of nearly all blood vessels that irrigate the cerebral cortex, the outermost layer of the brain involved with complex cognitive functions such as thought, perception, and memory formation. Cerebral cortex endothelial cells are integral to maintaining brain health and function due to their role in regulating brain microenvironment and controlling the passage of essential molecules and cells. The endothelial cells in the cerebral cortex are distinctive due to their highly selective permeability, largely attributable to the existence of unique tight junctions which maintain the barrier function of the BBB. The tightly interconnected structures of these cells prevent most substances from freely diffusing into the brain tissue, ensuring that harmful agents such as toxins, pathogens, or peripheral immune cells don't reach the brain and compromise its function. These cells also express multiple transporters and enzymes, allowing the selective entry of necessary nutrients and metabolites while excluding toxic substances. Cerebral cortex endothelial cells also participate in neurovascular coupling, a process where localized neuronal activity increases cerebral blood flow to satisfy the local metabolic demands. The endothelial cells work in coordination with neurons and other cell types such as astrocytes and pericytes to mediate this process. They have been thought to regulate local blood flow by releasing substances in response to neuronal activity. Additionally, these cells are involved in many pathological conditions. Breakdown or dysfunction of the BBB often marked by altered endothelial cell function is linked to numerous neurological disorders including stroke, multiple sclerosis, Alzheimer’s disease, and brain tumors. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "CALOHA:TS-2372" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001602 ; owl:annotatedTarget "cerebral cortex endothelial cells" . [] oboInOwl:hasDbXref "CALOHA:TS-2372" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001602 ; owl:annotatedTarget "endothelial cells of cerebral cortex" . [] a owl:Axiom ; rdfs:label "cerebral cortex endothelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1001602 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1001602" . [] oboInOwl:hasDbXref "HPA:HPA", "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001603 ; owl:annotatedTarget "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung." . [] oboInOwl:hasDbXref "DOI:10.1002/JLB.3RU0720-418R", "DOI:10.1016/j.immuni.2022.08.010", "DOI:10.1189/jlb.70.2.163", "DOI:10.3389/fimmu.2021.753940/full", "DOI:10.3390/cells10040897" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_1001603 ; owl:annotatedTarget """Lung macrophages refer to macrophage populations in the lungs, including the tissue-resident alveolar macrophages and interstitial macrophages, located in the air spaces and the connective tissue of the lung, respectively, and recruited macrophages. They are important in maintaining tissue homeostasis and immunity. The primary function of lung macrophages is to patrol and maintain the pulmonary system, where they serve as the first line of defense against airborne pathogens and inhaled particles. They perform phagocytosis of pathogens, particulate matter, dead cells, and other cellular debris from the lungs to maintain clear air passages and optimize gas exchange. They may also participate in tissue repair and the resolution of inflammation following injury. Lung macrophages also play a critical role in immune regulation. They help to initiate an immune response by secreting cytokines and other inflammatory mediators and by presenting antigens from the pathogens they have engulfed to induce T cell responses. However, if activated improperly, lung macrophages can contribute to inflammatory diseases of the lung such as chronic obstructive pulmonary disease (COPD) or asthma. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "CALOHA:TS-0576" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001603 ; owl:annotatedTarget "lung macrophages" . [] a owl:Axiom ; rdfs:label "lung macrophage on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_1001603 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_1001603" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000347 ; owl:annotatedTarget "A cell of the sclera of the eye." . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001606 ; owl:annotatedTarget "Keratinocyte from foreskin." . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001607 ; owl:annotatedTarget "Chondrocyte forming the hyaline cartilage found in joints." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000034 ; owl:annotatedTarget "ZFA:0005957" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000347 ; owl:annotatedTarget "ZFA:0009174" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001608 ; owl:annotatedTarget "Fibroblast from foreskin." . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001609 ; owl:annotatedTarget "Fibroblast from muscle organ." . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001610 ; owl:annotatedTarget "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." . [] oboInOwl:hasDbXref "CALOHA:TS-2109" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001610 ; owl:annotatedTarget "bone marrow hematopoietic cells" . [] oboInOwl:hasDbXref "CALOHA:TS-2109" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001610 ; owl:annotatedTarget "bone marrow poietic cells" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001611 ; owl:annotatedTarget "Neuron of the cerebellum." . [] oboInOwl:hasDbXref "CALOHA:TS-2359" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001611 ; owl:annotatedTarget "cerebellum neuron" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1100001 ; owl:annotatedTarget "An epithelial cell that is specialised for the synthesis and secretion of specific biomolecules." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000000 ; owl:annotatedTarget "Any melanocyte that is part of a epidermis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000001 ; owl:annotatedTarget "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." . [] oboInOwl:hasDbXref "BTO:0002770", "NCIT:C32429", "PMID:30013421", "PMID:30429548", "Wiki:Decidual_cells&oldid=937509751", "Wiki:Decidualization&oldid=908981933" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000002 ; owl:annotatedTarget "A specialized, enlarged, connective tissue cell of the decidua with enlarged nucleus, dense membrane‐bound secretory granules and cytoplasmic accumulation of glycogen and lipid droplets. These cells develop by the transformation of endometrial stromal cells during decidualization." . [] oboInOwl:hasDbXref "DOI:10.1002/rmb2.12088", "DOI:10.1093/humupd/dmw004", "DOI:10.1111/j.1749-6632.2010.05938.x", "DOI:10.3390/ijms21114092" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_2000002 ; owl:annotatedTarget """Decidual cells, originating from the endometrial lining in the uterus, undergo significant transformations during pregnancy and are integral to its preparation and maintenance. Their conversion from endometrial fibroblast to a secretory phenotype, known as decidualization, occurs as a normal process in the menstrual cycle or in response to embryo implantation. With crucial roles in regulating maternal immune responses and placental development, decidual cells have a twofold function: preventing rejection of the conceptus by the mother's immune system and guiding placental development to avoid excessive trophoblast invasion leading to pre-eclampsia. During decidualization, these cells secrete proteins and growth factors supporting embryo implantation and sustaining early pregnancy. Furthermore, decidual cells modulate the activities of natural killer cells, macrophages, and T cells in the uterus, maintaining a balance of pro-inflammatory and anti-inflammatory conditions during pregnancy. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "BTO:0002770", "NCIT:C32429" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_2000002 ; owl:annotatedTarget "decidua cell" . [] oboInOwl:hasDbXref "BTO:0005756", "PMID:11719592" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_2000002 ; owl:annotatedTarget "decidual stromal cell" . [] oboInOwl:hasDbXref "PMID:31907034" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_2000002 ; owl:annotatedTarget "decidualized endometrial stromal cell" . [] a owl:Axiom ; rdfs:label "decidual cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_2000002 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_2000002" . _:genid1645 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_6656, obo:UBERON_0001776 . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000004 ; owl:annotatedTarget "Any cell that is part of a pituitary gland." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000005 ; owl:annotatedTarget "Any macroglial cell that is part of a brain." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000006 ; owl:annotatedTarget "Any germinal center B cell that is part of a tonsil." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000348 ; owl:annotatedTarget "A structural cell that is part of optic choroid." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000007 ; owl:annotatedTarget "Chondrocyte forming the hyaline cartilage found in the knee joint." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000008 ; owl:annotatedTarget "Any blood vessel endothelial cell that is part of a microvascular endothelium." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000009 ; owl:annotatedTarget "Any blood vessel endothelial cell that is part of a microvascular endothelium." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000348 ; owl:annotatedTarget "ZFA:0009175" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000010 ; owl:annotatedTarget "Any blood vessel endothelial cell that is part of a dermis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000011 ; owl:annotatedTarget "Any endothelial cell of lymphatic vessel that is part of a dermis." . [] oboInOwl:hasDbXref "DOI:10.1038/s41423-023-01042-9", "DOI:10.1038/s41467-019-14127-9", "DOI:10.3389/fimmu.2023.1235812", "DOI:10.3389/fphys.2020.00509", "DOI:10.3389/fphys.2020.577584" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_2000011 ; owl:annotatedTarget """A dermis lymphatic vessel endothelial cell is a specialized type of cell that lines the interior surface of lymphatic vessels present in the dermal layer of the skin. These cells are organized into a single layer, forming an integral part of the lymphatic system which acts as the body's secondary circulatory system. The primary function of dermis lymphatic vessel endothelial cells is to facilitate the transportation and regulation of the lymph fluid within the dermis. They act as a barrier, contributing to fluid homeostasis, lipid transport, and immune cell trafficking. These cells are uniquely equipped to let fluid and larger molecules, including proteins and immune cells, into the lymphatic vessels from the surrounding interstitial space. This is enabled by the specialized junctions between the endothelial cells and the presence of primary lymphatic valves that prevent the backflow of lymph. Another paramount role of dermis lymphatic vessel endothelial cells is their involvement in immune response. By interacting with white blood cells, especially T-cells and dendritic cells, they can mediate local immune surveillance and contribute to both innate and adaptive immune responses. These cells are also implicated in a variety of pathological conditions, including lymphedema and metastasis in cancer. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "dermis lymphatic vessel endothelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_2000011 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_2000011" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000012 ; owl:annotatedTarget "Any skin fibroblast that is part of a pedal digit skin." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000013 ; owl:annotatedTarget "Any skin fibroblast that is part of a skin of abdomen." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000014 ; owl:annotatedTarget "Any skin fibroblast that is part of a upper leg skin." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000015 ; owl:annotatedTarget "Any skin fibroblast that is part of a arm." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000016 ; owl:annotatedTarget "Any lung endothelial cell that is part of a microvascular endothelium." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000017 ; owl:annotatedTarget "Any fibroblast that is part of a periodontal ligament." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000018 ; owl:annotatedTarget "Any endothelial cell of artery that is part of a coronary artery." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000349 ; owl:annotatedTarget "Any cell that is part of some extraembryonic structure." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000019 ; owl:annotatedTarget "Any photoreceptor cell that is part of a compound eye." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_2000019 ; owl:annotatedTarget "FBbt:00006009" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000020 ; owl:annotatedTarget "Any native cell that is part of a inner cell mass." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000349 ; owl:annotatedTarget "ZFA:0009176" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000021 ; owl:annotatedTarget "Any native cell that is part of a sebaceous gland." . [] oboInOwl:hasDbXref "DOI:10.1016/j.jid.2016.10.017", "DOI:10.1080/19381980.2017.1375636", "DOI:10.4161/derm.1.2.8472", "https://doi.org/10.2147/CLEP.S323744", "https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/sebum" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_2000021 ; owl:annotatedTarget """Sebaceous gland cells, also known as sebocytes, are small, oil-producing glands present in the skin of mammals. These specialized cells are predominantly located in the dermis, particularly on the face, scalp, and upper body. The primary function of sebaceous gland cells is the production and secretion of sebum, a complex mixture of lipids including triglycerides, wax esters, squalene, and metabolites of fat-soluble vitamins (such as vitamin E), as well as free fatty acids. The production process involves a unique form of programmed cell death called holocrine secretion. In this process, as sebaceous gland cells mature, they progressively accumulate lipid droplets, before ultimately disintegrating and releasing their lipid-rich contents into the gland's ductal system. The sebum generated by these cells serves multiple purposes. It acts as a waterproofing agent, preventing excessive wetting or drying of the skin and averaging skin's water-holding capacity. Sebum also has antimicrobial properties, providing a natural defense barrier against certain bacterial and fungal species. Additionally, it contributes to the skin’s suppleness and prevents it from becoming brittle. An overproduction or imbalance of sebaceous gland cells can lead to common skin disorders, such as acne, seborrhea, or rosacea, illustrating their importance in skin health. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "sebaceous gland cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_2000021 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_2000021" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000022 ; owl:annotatedTarget "Any native cell that is part of a cardiac septum." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000023 ; owl:annotatedTarget "Any interneuron that is part of a spinal cord ventral column." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000024 ; owl:annotatedTarget "Any neuron that is part of a spinal cord medial motor column." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000025 ; owl:annotatedTarget "Any oligodendrocyte that is part of a spinal cord." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000026 ; owl:annotatedTarget "Any Golgi cell that is part of a cerebellum." . [] oboInOwl:hasDbXref "PMID:32990595", "PMID:8915580" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000027 ; owl:annotatedTarget "A GABAergic inhibitory interneuron located in the molecular layer of the cerebellar cortex. It projects axons that form specialized synaptic structures around Purkinje cells, including pericellular baskets, which wrap around the Purkinje cell soma, and the pinceau: a brush-like terminal that contacts the initial segment of the Purkinje cell axon. The basket cell modulates Purkinje cell activity through both chemical (GABAergic) and non-synaptic (ephaptic) mechanisms. It is arranged in sagittal rows that align with Purkinje cell zones, contributing to the cerebellum's modular and topographically organized architecture. It plays an essential role in regulating motor coordination and potentially cognitive functions." . [] dc:license ; oboInOwl:hasDbXref "doi:10.1016/j.cnp.2022.11.002" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_2000027 ; owl:annotatedTarget . [] dc:license ; oboInOwl:hasDbXref "doi:10.3389/fnins.2020.00293" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_2000027 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000028 ; owl:annotatedTarget "Any glutamatergic neuron that is part of a cerebellum." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000029 ; owl:annotatedTarget "Any neuron that is part of a central nervous system." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000030 ; owl:annotatedTarget "Any native cell that is part of a hypothalamus." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000350 ; owl:annotatedTarget "Any extraembryonic cell that is part of some amnioserosa." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000031 ; owl:annotatedTarget "Any neuron that is part of a lateral line ganglion." . [] oboInOwl:hasDbXref "GOC:TermGenie", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000032 ; owl:annotatedTarget "A neuron that is part of a peripheral nervous system." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000033 ; owl:annotatedTarget "Any basal cell of epidermis that is part of a limb." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000034 ; owl:annotatedTarget "Any neuromast hair cell that is part of a anterior lateral line." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000351 ; owl:annotatedTarget obo:CL_0000349 . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000035 ; owl:annotatedTarget "Any neuromast mantle cell that is part of an anterior lateral line." . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D014327", "PMID:37630754", "doi:10.1007/978-3-030-84725-8" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000351 ; owl:annotatedTarget "An extraembryonic cell that develops from a trophectodermal cell. This cell is found in the outer layer of the blastocyst and can invade other structures in the uterus once the blastocyst implants into the uterine wall. A trophoblast cell is involved in the implantation of the embryo into the uterine wall, placental formation, remodelling of maternal vasculature in the uterus, nutrient and gas exchange, hormone production, and immune modulation to support fetal development." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000036 ; owl:annotatedTarget "Any neuromast support cell that is part of a anterior lateral line." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000037 ; owl:annotatedTarget "Any neuromast hair cell that is part of a posterior lateral line." . [] oboInOwl:hasDbXref "DOI:10.1016/j.jri.2023.103811", "DOI:10.1530/JOE-17-0402", "https://www.ncbi.nlm.nih.gov/books/NBK53245" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000351 ; owl:annotatedTarget """Trophoblast cells, originating from the blastocyst's outer layer, are highly specialized and pivotal for embryo development. Their crucial roles include facilitating implantation and contributing to the formation of the placenta, an essential organ for fetal nutrition, gas exchange, and waste removal during pregnancy. These cells play a crucial role in implantation by adhering to the uterus lining. Post-implantation, some trophoblast cells differentiate, forming syncytiotrophoblasts. These multi-nucleated cells absorb nutrients, release waste, and secrete hormones, including human chorionic gonadotropin (hCG), sustaining pregnancy. Trophoblast cells also play a crucial role in immune tolerance, preventing the maternal immune system from treating the fetus as foreign. This balance is vital for a healthy pregnancy. Dysfunctional trophoblast cells may lead to complications like miscarriages or preeclampsia, emphasizing their importance in both embryology and reproductive medicine. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000038 ; owl:annotatedTarget "Any neuromast mantle cell that is part of a posterior lateral line." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000039 ; owl:annotatedTarget "Any neuromast support cell that is part of a posterior lateral line." . [] oboInOwl:hasDbXref "doi:10.1007/978-3-030-84725-8" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000351 ; owl:annotatedTarget "trophoblastic cell" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000040 ; owl:annotatedTarget "Any microvascular endothelial cell that is part of a urinary bladder." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000041 ; owl:annotatedTarget "Any dermis lymphatic vessel endothelial cell that is part of a microvascular endothelium." . [] a owl:Axiom ; rdfs:label "trophoblast cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000351 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000351" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000042 ; owl:annotatedTarget "Any fibroblast that is part of a embryo." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000352 ; owl:annotatedTarget "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000043 ; owl:annotatedTarget "Any pericyte cell that is part of a brain." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000044 ; owl:annotatedTarget "Any microvascular endothelial cell that is part of a brain." . [] oboInOwl:hasDbXref "MESH:D001756" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000353 ; owl:annotatedTarget "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000045 ; owl:annotatedTarget "Any melanocyte of skin that is part of a skin of prepuce of penis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000046 ; owl:annotatedTarget "Any cardiac muscle cell that is part of a cardiac ventricle." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000353 ; owl:annotatedTarget "ZFA:0009177" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "DOI:10.1016/j.peptides.2018.05.012", "DOI:10.1126/science.aam5894", "https://www.ncbi.nlm.nih.gov/books/NBK535355", "https://www.ncbi.nlm.nih.gov/books/NBK572070/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_2000046 ; owl:annotatedTarget """Ventricular cardiac muscle cells, or cardiomyocytes, are specialized cells found in the ventricular walls of the heart. They exhibit unique features, including centrally located nuclei, robust cytoskeletal structures, high mitochondria content, and intercalated discs, which contribute to their efficient pumping of blood throughout the body. The main role of ventricular cardiac muscle cells is to coordinate contractions, enabling the heart to pump blood throughout the body. This is achieved through controlled ion movement across cell membranes, generating rhythmic electrical signals called action potentials. Intercalated discs between these cells aid synchronized contractions by allowing efficient signal spread through gap junctions. The high mitochondrial content ensures a constant energy supply for this ongoing contraction cycle. Ventricular cardiac muscle cells contribute not only mechanically but also biochemically by secreting essential hormones like atrial natriuretic peptide and B-type natriuretic peptide for blood pressure regulation and cardiac remodeling. These cells exhibit low turnover under normal conditions, emphasizing their long-term stability, yet have limited regenerative capacity following cardiac injuries. Dysfunction in these cells can result in significant cardiac issues, including heart failure. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "ventricular cardiac muscle cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_2000046 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_2000046" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000047 ; owl:annotatedTarget "Any motor neuron that is part of a brainstem." . [] oboInOwl:hasDbXref "DOI:10.1016/B978-0-12-817962-8.00025-1" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000048 ; owl:annotatedTarget "A lower motor neuron whose soma is located in the anterior horn. Anterior horn motor neurons project from the anterior portion of the grey matter in the spinal cord to some skeletal muscles." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000354 ; owl:annotatedTarget "ZFA:0009178" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000049 ; owl:annotatedTarget "Any pyramidal cell that is part of a primary motor cortex." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000050 ; owl:annotatedTarget "Any retinal ganglion cell that is part of a retina." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000051 ; owl:annotatedTarget "Any fibroblast that is part of a spleen." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000052 ; owl:annotatedTarget "Any endothelial cell of artery that is part of a umbilical cord." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000053 ; owl:annotatedTarget "Any endothelial cell that is part of a spleen." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM559.FNBB.6273" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_2000053 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-white-pulp/v1.2/assets/2d-ftu-spleen-white-pulp.png" . [] oboInOwl:hasDbXref "GOC:dos", "PMID:9408963" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000054 ; owl:annotatedTarget "A large, granular, liver specific natural killer cell that adheres to the endothelial cells of the hepatic sinusoid." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000055 ; owl:annotatedTarget "Any dendritic cell that is part of a liver." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000056 ; owl:annotatedTarget "Any pyramidal cell that is part of a regional part of cerebral cortex." . [] oboInOwl:hasDbXref "GOC:TermGenie", "PMID:34565180", "PMID:34569806" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000057 ; owl:annotatedTarget "Any osteoblast that is part of a femur." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000058 ; owl:annotatedTarget "Any osteoblast that is part of a skull." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000355 ; owl:annotatedTarget obo:CL_0000048 . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000059 ; owl:annotatedTarget "Any microvascular endothelial cell that is part of a prostate gland." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM347.TXWZ.899" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_2000059 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" . [] oboInOwl:hasDbXref "PMID:31049600" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000060 ; owl:annotatedTarget "A trophoblast of placental villi. These cells fuse to form synctial trophoplast - the placental side of the interface between the placenta and maternal blood sinusoids in the decidua." . [] oboInOwl:hasDbXref "DOI:10.1007/s00018-019-03104-6", "DOI:10.3389/fimmu.2020.00343", "DOI:10.3390/nu15163564" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_2000060 ; owl:annotatedTarget """The placental villous trophoblast, a highly specialized cell type crucial for placental development, plays a key role in facilitating exchanges between the maternal bloodstream and the developing fetus. Structurally, placental villous trophoblasts are situated on the villous tree structures, forming an outer epithelial layer. Comprising two subtypes—proliferating cytotrophoblasts forming the inner layer and terminally differentiated syncytiotrophoblasts constituting the outer layer in contact with maternal blood—these cells define the placental architecture. Functionally, placental villous trophoblasts play pivotal roles in forming and maintaining the placenta, ensuring the safe development of the fetus. Their primary function involves managing substance exchange between the mother and fetus, mediating the transfer of gases, nutrients, hormones, and waste materials to support optimal fetal growth. Additionally, these trophoblasts synthesize and release crucial hormones like human chorionic gonadotropin (hCG), which maintains the decidua and signals the mother's body to sustain pregnancy. Acting as a physical and immunological barrier, they protect the fetus from maternal immune cells and prevent the transmission of pathogens, contributing significantly to the success of pregnancy. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "PMID:31049600" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_2000060 ; owl:annotatedTarget "vCTB" . [] oboInOwl:hasDbXref "PMID:18282570" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000355 ; owl:annotatedTarget "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." . [] a owl:Axiom ; rdfs:label "placental villous trophoblast on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_2000060 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_2000060" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000061 ; owl:annotatedTarget "Any mesenchymal stem cell that is part of a placenta." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000355 ; owl:annotatedTarget "ZFA:0009179" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000062 ; owl:annotatedTarget "Any capillary endothelial cell that is part of a placenta." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000063 ; owl:annotatedTarget "Any fibroblast that is part of a female gonad." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000357 ; owl:annotatedTarget "ZFA:0009180" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:TermGenie", "PMID:12052228", "PMID:15749958", "PMID:23467088", "PMID:31672973", "PMID:36205477" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000064 ; owl:annotatedTarget "A meso-epithelial cell of the ovarian surface epithelium, varying in shape from flat to cuboidal to pseudostratified columnar. This cell plays a crucial role in ovulation by producing proteolytic enzymes in response to gonadotropins, facilitating follicle rupture through tissue breakdown and TNF-alpha signaling. Additionally, this cell contributes to post-ovulatory wound repair (Morris et al., 2022) and exhibits stem cell-like properties (Flesken-Nikitin et al., 2013; Wang et al., 2019)." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000065 ; owl:annotatedTarget "Any microvascular endothelial cell that is part of a female urethra." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000066 ; owl:annotatedTarget "Any fibroblast that is part of a cardiac ventricle." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000067 ; owl:annotatedTarget "Any fibroblast that is part of a cardiac atrium." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000068 ; owl:annotatedTarget "Any fibroblast that is part of a pericardium." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000069 ; owl:annotatedTarget "Any fibroblast that is part of a gallbladder." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000070 ; owl:annotatedTarget "Any fibroblast that is part of a optic choroid." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000071 ; owl:annotatedTarget "Any microvascular endothelial cell that is part of a breast." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000072 ; owl:annotatedTarget "Any microvascular endothelial cell that is part of a adipose tissue." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000073 ; owl:annotatedTarget "Any migratory neural crest cell that is part of a cardiac neural crest." . [] oboInOwl:hasDbXref "PMID:33060096" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_2000073 ; owl:annotatedTarget "cardiac neural crest cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000358 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000074 ; owl:annotatedTarget "Any leukocyte that is part of a spleen." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000075 ; owl:annotatedTarget "Any endodermal cell that is part of a anterior visceral endoderm." . [] oboInOwl:hasDbXref "GOC:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000358 ; owl:annotatedTarget "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000076 ; owl:annotatedTarget "Any vein endothelial cell that is part of a hindlimb stylopod." . [] oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK482438/", "https://www.ncbi.nlm.nih.gov/books/NBK532857/", "https://www.ncbi.nlm.nih.gov/books/NBK557452/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000358 ; owl:annotatedTarget """Smooth muscle cells, as a broader category, are non-striated, involuntary muscle cells that usually exhibit contractions and dilation to facilitate numerous physiological functions. Sphincter associated smooth muscle cells are a specific type of smooth muscle cell that are primarily associated with the functioning of various anatomical sphincters in the human body. The traits that distinguishes sphincter associated smooth muscle cells from other smooth muscle cells are their location and specialized function in sphincter mechanisms. Sphincter associated smooth muscle cells play a pivotal role in regulating the opening and closure of the bodily sphincters. These sphincters can be found at multiple locations within the body including the gastrointestinal tract (namely the esophagus, stomach, small intestine, and rectum), the urinary tract, and the circulatory system. Upon receiving signals from the autonomous nervous system, these cells contract or relax to modulate the aperture of sphincters, thus controlling the movement of substances through them. Due to their precise and vital functional role, any dysfunction or dysregulation in these cells can lead to serious medical conditions, such as gastroesophageal reflux or urinary incontinence. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000077 ; owl:annotatedTarget "Any striated muscle cell that is part of a skeletal muscle tissue of pectoralis major." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000078 ; owl:annotatedTarget "Any pericyte cell that is part of a placenta." . [] a owl:Axiom ; rdfs:label "sphincter associated smooth muscle cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000358 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000358" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000079 ; owl:annotatedTarget "Any mesenchymal stem cell of the bone marrow that is part of a femur." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000080 ; owl:annotatedTarget "Any mesenchymal stem cell of adipose tissue that is part of an abdomen." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000081 ; owl:annotatedTarget "Any melanocyte of skin that is part of a skin of face." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000082 ; owl:annotatedTarget "OBSOLETE. Any melanocyte of skin that is part of a skin of prepuce of penis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000083 ; owl:annotatedTarget "Any hair follicle dermal papilla cell that is part of a scalp." . [] oboInOwl:hasDbXref "GOC:TermGenie", "PMID:27091323", "PMID:28475124", "PMID:31734511" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000084 ; owl:annotatedTarget "A goblet cell that is part of the conjunctival epithelium, characterized by apical accumulation of mucin granules (containing MUC5AC in humans; Muc5ac/Muc5b in mice). These gel-forming mucins support tear film stability, ocular lubrication, and pathogen defence. The conjunctival goblet cell forms tight junctions with neighbouring epithelial cells via species-specific claudins (claudin-10 in humans, claudin-2 in mice) and regulates immune homeostasis by facilitating soluble antigen transport to dendritic cells through goblet cell-associated antigen passages (GAPs) (Barbosa et al., 2017). The transcription factor SPDEF is essential for its differentiation." . [] oboInOwl:hasDbXref "PMID:31734511" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_2000084 ; owl:annotatedTarget "CGC" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000085 ; owl:annotatedTarget "Any mononuclear cell that is part of a umbilical cord." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000086 ; owl:annotatedTarget "Any basket cell that is part of a neocortex." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000087 ; owl:annotatedTarget "Any basket cell that is part of a dentate gyrus of hippocampal formation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000088 ; owl:annotatedTarget "Any basket cell that is part of a Ammon's horn." . [] oboInOwl:hasDbXref "GOC:TermGenie", "PMID:17765709" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000089 ; owl:annotatedTarget "A granule cell that has soma location in the dentate gyrus cell layer of the hippocampal formation and has an elliptical cell body and characteristic cone-shaped tree of spiny apical dendrites. The branches extend throughout the molecular layer and the distal tips of the dendritic tree end just at the hippocampal fissure or at the ventricular surface. The dentate gyrus granule cell is the principal cell type of the dentate gyrus." . [] oboInOwl:hasDbXref "PMID:17765709" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_2000089 ; owl:annotatedTarget "As far as can be determined, all dentate granule cells appear to project to CA3 and the axon trajectory is partially correlated with the position of the parent cell body." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000359 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000090 ; owl:annotatedTarget "Any stellate cell that is part of a dentate gyrus of hippocampal formation." . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000359 ; owl:annotatedTarget "A smooth muscle cell associated with the vasculature." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000091 ; owl:annotatedTarget "Any microvascular endothelial cell that is part of a endometrial blood vessel." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000092 ; owl:annotatedTarget "Any keratinocyte that is part of a hair follicle." . [] oboInOwl:hasDbXref "DOI:10.1093/cvr/cvs135", "DOI:10.1093/cvr/cvy023", "DOI:10.1161/ATVBAHA.118.311229", "DOI:10.3389/fimmu.2020.599415", "DOI:10.3390/ijms20225694" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000359 ; owl:annotatedTarget """Vascular associated smooth muscle cells (VSMCs) are specialized cells that constitute a major component of the blood vessel wall in the circulatory system. They derive their name from the predominantly smooth appearance under microscopic examination, as opposed to the striated appearance of cardiac and skeletal muscles. A principal function of VSMCs is to regulate vascular tone, which directly dictates blood pressure and blood flow distribution across various body parts. This is achieved through coordinated contraction and relaxation of the muscles in response to a variety of extracellular signals. When a blood vessel is exposed to stimuli like pressure or injury, VSMCs contract, resulting in vasoconstriction and ultimately, an increase in blood pressure. Conversely, in response to vasodilators, these cells relax, leading to vasodilation and a consequent decrease in blood pressure. VSMCs are also involved in vascular remodeling, a process where blood vessels adapt their structure to long-term changes in hemodynamic conditions or disease states. In diseases like atherosclerosis and hypertension, an aberrant proliferative and synthetic phenotype of VSMCs contributes to the formation of plaques, leading to vessel hardening or even occlusion. Recent research has further implicated these cells in immune responses, recognizing their function in leukocyte recruitment and inflammation, factors that are largely instrumental in vascular pathologies. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000093 ; owl:annotatedTarget "Any fibroblast of lung that is part of a bronchus." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000094 ; owl:annotatedTarget "Any epithelial cell of viscerocranial mucosa that is part of a nasal cavity respiratory epithelium." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000359 ; owl:annotatedTarget "ZFA:0009181" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000095 ; owl:annotatedTarget "Any hematopoietic stem cell that is part of a umbilical cord blood." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000096 ; owl:annotatedTarget "Any fibroblast that is part of a reticular layer of dermis." . [] a owl:Axiom ; rdfs:label "vascular associated smooth muscle cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000359 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000359" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000097 ; owl:annotatedTarget "Any dopaminergic neuron that is part of a midbrain." . [] oboInOwl:hasDbXref "GOC:CellBLAST", "PMID:29802404" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_3000000 ; owl:annotatedTarget "A ciliated epithelial cell of the esophagus." . [] oboInOwl:hasDbXref "GOC:CellBLAST", "PMID:30429548", "PMID:30498493", "PMID:34745147", "PMID:35438172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_3000001 ; owl:annotatedTarget "A tissue-resident macrophage that is part of the placenta. A Hofbauer cell expresses high levels of growth factors and metalloproteinases that support vasculogenesis, angiogenesis, branching morphogenesis and tissue remodeling. A Hofbauer cell has a fetal origin, is found in the villous stroma, chorion, and amnion, and is present throughout pregnancy." . [] oboInOwl:hasDbXref "PMID:39007150" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_3000001 ; owl:annotatedTarget "fetal Hofbauer cell" . [] oboInOwl:hasDbXref "PMID:39007150" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_3000001 ; owl:annotatedTarget "HBC" . [] oboInOwl:hasDbXref "PMID:30498493" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_3000001 ; owl:annotatedTarget "Hofbauer cells are a heterogenic group of macrophages that resemble M2-like cells. Initially described in chorionic villi in humans, a Hofbauer cell is now often used to describe any fetal-derived placental macrophage that resides within the placental villous core, amnion, and chorion laeve." . [] oboInOwl:hasDbXref "GOC:CellBLAST", "PMID:30096314" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_3000002 ; owl:annotatedTarget "Sympathetic noradrenergic neuron." . [] oboInOwl:hasDbXref "MESH:D009028" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000360 ; owl:annotatedTarget "A cell of the early embryo at the developmental stage in which the blastomeres, resulting from repeated mitotic divisions of the fertilized ovum (zygote), form a compact cell mass." . [] oboInOwl:hasDbXref "GOC:CellBLAST", "PMID:30096314" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_3000003 ; owl:annotatedTarget "A type of autonomic neuron that releases acetylcholine." . [] oboInOwl:hasDbXref "GOC:CellBLAST", "PMID:30096314", "PMID:31554486", "PMID:35858549", "Wikipedia:Sensory_neuron", "https://www.britannica.com/science/sensory-neuron", "https://www.ncbi.nlm.nih.gov/books/NBK539846/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_3000004 ; owl:annotatedTarget "A neuron type that is located in a peripheral nervous system and it transmits sensory information from the peripheral (PNS) to the central nervous system (CNS). A sensory neuron converts physical (light, sound, touch) or chemical (such as taste and smell) stimuli into an electrical signal through a process known as sensory transduction. The function of a sensory neuron is to carry informations from the external environment and internal body conditions to the central nervous system for further processing." . [] oboInOwl:hasDbXref "Wikipedia:Sensory_neuron" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_3000004 ; owl:annotatedTarget "Typically, a sensory neuron has a pseudounipolar morphology." . [] oboInOwl:hasDbXref "PMID:25346659" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023000 ; owl:annotatedTarget "A motor neuron that innervates both intrafusal and extrafusal muscle fibers. Low abundancy. They control both muscle contraction and responsiveness of the sensory feedback from muscle spindles." . [] oboInOwl:hasDbXref "MESH:D005775" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000361 ; owl:annotatedTarget "A cell of the embryo in the early stage following the blastula, characterized by morphogenetic cell movements, cell differentiation, and the formation of the three germ layers." . [] oboInOwl:hasDbXref "PMID:25346659" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023001 ; owl:annotatedTarget "A beta motor neuron that innervates nuclear chain fibers." . [] oboInOwl:hasDbXref "PMID:25346659" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023002 ; owl:annotatedTarget "A beta motor neuron that innervates the nuclear bag fibers of muscle spindles." . [] oboInOwl:hasDbXref "DOI:10.1016/B978-0-323-39632-5.00024-4", "PMID:139469" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023003 ; owl:annotatedTarget "A type of intrafusal muscle fiber that has nuclei arranged in a linear row. Unlike nuclear bag fibers, the equatorial region of these fibers (in the centre of the spindle) is not expanded. These fibers are responsible for the detection of changes in muscle length. They are innervated by static gamma motor neurons and are principally associated with type II sensory fibers." . [] oboInOwl:hasDbXref "DOI:10.1016/B978-0-323-39632-5.00024-4", "PMID:139469" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023004 ; owl:annotatedTarget "A type of intrafusal muscle fiber that lies in the center of a muscle spindle. Nuclei are clustered centrally and give the equatorial region a swollen appearance. They are associated with associated with dynamic gamma motor neurons, and the stretching of the equatorial region of the nuclear bag fibers results in an increase in the firing rate of type Ia sensory fibers." . [] oboInOwl:hasDbXref "DOI:10.1016/B978-0-323-39632-5.00024-4" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023005 ; owl:annotatedTarget "A nuclear bag fiber that is sensitive mainly to the rate of change in muscle length." . [] oboInOwl:hasDbXref "DOI:10.1016/B978-0-323-39632-5.00024-4" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023006 ; owl:annotatedTarget "A nuclear bag fiber that is sensitive only changes in muscle length but not the rate of that change." . [] oboInOwl:hasDbXref "PMID:26420784" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023007 ; owl:annotatedTarget "A VIP GABAergic cortical interneuron with bipolar morphology, with a soma found in L2/3. L2/3 bipolar VIP cells have extending axons across all layers (with preferences for layers II/III and Va) and a dendritic tree that is vertically more restricted than deeper layer VIP cells and extend fewer dendrites into the layers outside their home layer (location of soma). L2/3 bipolar VIP cells have great variability in firing patterns, though most are continuous adapting. L2/3 bipolar VIP cells are more depolarized in their resting state, had less fast rectification, and had smaller after hyperpolarization than deeper VIP cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000361 ; owl:annotatedTarget "ZFA:0009182" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:34616075" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023008 ; owl:annotatedTarget "A glutamatergic neuron located in the cerebral cortex that projects to structures of telencephalic origins." . [] oboInOwl:hasDbXref "doi:10.1038/s41467-021-24565-z" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023008 ; owl:annotatedTarget "IT neuron" . [] oboInOwl:hasDbXref "DOI:10.1101/2020.10.19.343129" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023009 ; owl:annotatedTarget "A glutamatergic neuron located in the cerebral cortex that projects to structures not derived from telencephalon." . [] oboInOwl:hasDbXref "PMID:30413647", "PMID:33184512" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023010 ; owl:annotatedTarget "A GABAergic cortical interneuron that is strongly labelled for α7 nAChRs. These cells have soma found in L1 and have multipolar dendrites with vertically descending axonal collaterals that project deep into the column, usually branching and terminating in L5A." . [] oboInOwl:hasDbXref "DOI:10.1101/2020.10.19.343129", "PMID:30413647", "PMID:33184512" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023010 ; owl:annotatedTarget "Unlike typical Lamp5 electrophysiology, A7 cells have Vip- and Sst-like firing properties, with active depolarizing hump at near-threshold membrane potentials, and larger hyperpolarization sag, stronger burst, and rebound firing. A7 cells have a transcriptomics signature that looks like Lamp5 GABAergic interneuron." . [] oboInOwl:hasDbXref "PMID:30382198", "PMID:37824655", "https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023011 ; owl:annotatedTarget "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Lamp5. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Lamp5." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023011 ; owl:annotatedTarget "The marker set LINC00298, KIT can identify the Human cell type lamp5 GABAergic cortical interneuron in the neocortex with a confidence of 0.814687838 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "DOI:10.1101/2020.10.19.343129" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023012 ; owl:annotatedTarget "A glutamatergic neuron located in the cerebral cortex that projects axons locally rather than distantly." . [] oboInOwl:hasDbXref "DOI:10.1101/2020.10.19.343129" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023013 ; owl:annotatedTarget "A glutamatergic neuron located in the cerebral cortex that projects to the thalamus." . [] oboInOwl:hasDbXref "PMID:26420784", "PMID:26612957" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023014 ; owl:annotatedTarget "A VIP GABAergic cortical interneuron with a soma found in L5. L5 VIP cells have mostly local morphology with some deep-projecting axons. They show only moderate resistance, comparable to that of sst subclass and unlike typical VIP subclass cells that tend to show high input resistance. L5 VIP cells show particularly low resting membrane potential." . [] oboInOwl:hasDbXref "Flybase:dsj", "MA:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000362 ; owl:annotatedTarget "An epithelial cell of the integument (the outer layer of an organism)." . [] oboInOwl:hasDbXref "PMID:33186530", "PMID:37824655", "https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023015 ; owl:annotatedTarget "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Gamma-synuclein. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Sncg." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023015 ; owl:annotatedTarget "The marker set RXRG, THSD7B can identify the Human cell type sncg GABAergic cortical interneuron in the neocortex with a confidence of 0.628943702 (NS-Forest FBeta value)." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000362 ; owl:annotatedTarget "ZFA:0009183" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:33186530", "PMID:37824655", "https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023016 ; owl:annotatedTarget "A transcriptomically distinct cortical GABAergic neuron that expresses the vasocactive intestinal polypeptide and that has its soma located in the cerebral cortex. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Vip." . [] oboInOwl:hasDbXref "PMID:26420784", "PMID:31210267", "PMID:33794534", "PMID:35221922" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_4023016 ; owl:annotatedTarget "This neuronal type is distinguished by its heterogeneous morphology and electrophysiological characteristics (Pronneke et al., 2015,2020; Apicella and Marchionni, 2022). Variations in morphology and firing patterns are observed in human cortical VIP interneurons. In a study by Lee et al., 2023, four distinct subtypes of VIP neurons were identified, each exhibiting unique morphologies, soma locations, and electrophysiological properties. These subtypes are defined according to their transcriptomic markers: LBH-VIP and CCD184-VIP, both of which display a bipolar morphology with axons and dendrites extending across cortical layers; and SY16-VIP and ADAMTSL1-VIP, characterized by a dendritic arbor that spreads horizontally within the same layer as the soma (Lee et al., 2023). Disruption or malfunction of VIP cortical interneuron is implicated in neurodevelopmental disorders such as Rett Syndrome and Dravet Syndrome (Goff and Goldberg 2021)." . [] oboInOwl:hasDbXref "PMID:33108272" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4023016 ; owl:annotatedTarget "VIP interneuron" . [] oboInOwl:hasDbXref "PMID:33108272" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4023016 ; owl:annotatedTarget "VIP neuron" . [] oboInOwl:hasDbXref "PMID:35221922" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4023016 ; owl:annotatedTarget "VIP-Expressing GABAergic Neuron" . [] oboInOwl:hasDbXref "FMA:62411" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000362 ; owl:annotatedTarget "cell of epidermis" . [] oboInOwl:hasDbXref "ILX:0770151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4023016 ; owl:annotatedTarget "Vip GABAergic neuron" . [] oboInOwl:hasDbXref "PMID:37824655" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023016 ; owl:annotatedTarget "VIP type" . [] oboInOwl:hasDbXref "PMID:33794534" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023016 ; owl:annotatedTarget "VIP-IN" . [] oboInOwl:hasDbXref "ILX:0770151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023016 ; owl:annotatedTarget "Vip" . [] oboInOwl:hasDbXref "PMID:36384143" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023016 ; owl:annotatedTarget "cortical VIP neuron" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023016 ; owl:annotatedTarget "The marker set VIP can identify the Human cell type VIP GABAergic cortical interneuron in the neocortex with a confidence of 0.855531344 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "FMA:62411" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_0000362 ; owl:annotatedTarget "epithelial cell of skin" . [] oboInOwl:hasDbXref "PMID:27477017", "PMID:33742131", "PMID:37824655", "https://cellxgene.cziscience.com/e/9c63201d-bfd9-41a8-bbbc-18d947556f3d.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023017 ; owl:annotatedTarget "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses somatostatin (sst). The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Sst." . [] oboInOwl:hasDbXref "PMID:30001424" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023017 ; owl:annotatedTarget "SOM+ inhibitory interneuron" . [] oboInOwl:hasDbXref "PMID:33742131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023017 ; owl:annotatedTarget "SST+ IN" . [] oboInOwl:hasDbXref "PMID:30001424" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023017 ; owl:annotatedTarget "somatostatin-expressing inhibitory interneuron" . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000363 ; owl:annotatedTarget "Obsolete. Use PO:0000081 from Plant Ontology instead. OBSOLETE, use term from the Plant Ontology. A secondary vascular cell that develops from the fusiform cambial initials and oriented with their longest diameter parallel with the main axis of stem or root. These cells make up the axial system, also known as vertical or longitudinal system." . [] oboInOwl:hasDbXref "PMID:28821651", "PMID:30792151", "PMID:32494634", "PMID:33742131" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023017 ; owl:annotatedTarget "In the mouse cortex, sst GABAergic cortical interneurons show heterogeneous electrophysiological signatures varying between low-threshold spiking (LTS), regular-spiking and fast-spiking (Song, Y. H., Yoon, J., & Lee, S. H. 2021). Sst GABAergic cortical interneurons have multiple functional roles in the brain. In the mouse, they involved in the generation of slow-waves during the sleep phase of non-rapid eye-movement (NREM) (Funk, C. M. et al., 2017), they maintain synaptic plasticity during motor learning (Adler, A., Zhao, R., et al., 2021), they enhance visual perception in the V1 cortical area by suppressing the activity of pyramidal excitatory neurons (Song, YH. et al., 2020). In humans, malfunctioning of sst GABAergic cortical interneurons is associated with neurodegenerative and psychiatric disorders such as Parkinson's disease, Alzheimer's disease, major depressive disorder, bipolar disorder and schizophrenia as individuals affected by these pathologies show a decrease of expression of SST in the brain (Song YH., Yoon J. et al., 2021)." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023017 ; owl:annotatedTarget "The marker set SST, PLCH1 can identify the Human cell type sst GABAergic cortical interneuron in the neocortex with a confidence of 0.842367005 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000364 ; owl:annotatedTarget "Obsolete. Consult Plant Ontology. A cell that develops from the ray initial and composes all rays (panels of tissue variable in height and width, formed by the ray initials in the vascular cambium and extending radially in the secondary xylem and secondary phloem) in the secondary vascular tissues." . [] oboInOwl:hasDbXref "PMID:27477017", "PMID:37824655", "https://cellxgene.cziscience.com/e/9c63201d-bfd9-41a8-bbbc-18d947556f3d.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023018 ; owl:annotatedTarget "A transcriptomically distinct GABAergic interneuron with a soma located in a cerebral cortex and it expresses Parvalbumin. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Pvalb." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023018 ; owl:annotatedTarget "The marker set PVALB, TAC1, MYO5B can identify the Human cell type pvalb GABAergic cortical interneuron in the neocortex with a confidence of 0.691998764 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "PMID:33184512" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023019 ; owl:annotatedTarget "A VIP GABAergic cortical interneuron that expresses cck. L5/6 cck cells have soma found mainly in L5 and L6 and have large axonal arborization." . [] oboInOwl:hasDbXref "PMID:13933877", "PMID:139469", "WikipediaVersion:Gamma_motor_neuron&oldid=906640465" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023020 ; owl:annotatedTarget "A gamma motor neuron that innervates dynamic nuclear bag fibers (bag1 fibers) and enhances the sensitivities of Ia sensory neurons. They alter muscle spindle sensitivity and increases its discharge in response to velocity of muscle length (rather than just magnitude)." . [] oboInOwl:hasDbXref "PMID:13933877", "PMID:139469", "WikipediaVersion:Gamma_motor_neuron&oldid=906640465" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023021 ; owl:annotatedTarget "A gamma motor neuron that innervates static nuclear bag fibers (bag2 fibers) and increases their firing, in response to an increase in the magnitude of change in length, and controls the static sensitivity of the stretch reflex." . [] oboInOwl:hasDbXref "PMID:30413647" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023022 ; owl:annotatedTarget "A Lamp5 GABAergic cortical interneuron that has extended axons in the surface of L1. Canopy Lamp5 cells resemble neurogliaform cells in having elongated horizontal axonal arbors largely confined to L1; but the dendritic arbors are wider and have fewer branches, while the axon is less tortuous and extends further from the soma" . [] oboInOwl:hasDbXref "PMID:26727548" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023023 ; owl:annotatedTarget "A lamp 5 GABAergic cortical interneuron with neurogliaform morphology with a soma found in L5,6. L5,6 NGC lamp5 have deep afterhyperpolarization (AHP) but narrow action potentials (APs). Unlike other deep neurogliaform cells (which are caudal ganglionic eminence (CGE) derived), L5,6 NGC lamp5 cells are medial ganglionic eminence (MGE)-derived" . [] oboInOwl:hasDbXref "PMID:27477017" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023024 ; owl:annotatedTarget "A lamp5 GABAergic cortical interneuron with layer-adapting morphology. NGC lamp5 cells have a small round soma, short dendrites, and a wide dense axonal arbor that tends to establish a dense axonal mesh with high connection probability both to themselves and L2 pyramidal cells. NGC lamp5 cells have unique synaptic properties that distinguish them from other GABAergic interneurons, including the release of GABA to the extracellular space via volume transmission, and the ability to produce GABA-B responses in connected postsynaptic targets." . [] oboInOwl:hasDbXref "PMID:26727548" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023025 ; owl:annotatedTarget "A sst GABAergic cortical interneuron that is both an interneuron and a projecting neuron. They are found in all layers from upper L2/3 down to the bottom of L6. They have long-range projections, some with axons fading into white matter. These cells have low rebound potential, low hyperpolarization sag, and high variability in membrane time constant." . [] oboInOwl:hasDbXref "PMID:34727523", "WikipediaVersioned:Medium_spiny_neuron&oldid=1109726850" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023026 ; owl:annotatedTarget "A medium spiny neuron that expresses dopamine type 1 receptors and projects to the globus pallidus internus or the substantia nigra pars reticulata." . [] oboInOwl:hasDbXref "PMID:34727523" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023026 ; owl:annotatedTarget "D1-MSN" . [] oboInOwl:hasDbXref "PMID:30096299" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023026 ; owl:annotatedTarget "dSPN" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-7258-9596" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023026 ; owl:annotatedTarget "dopamine 1 medium spiny neuron" . [] oboInOwl:hasDbXref "PMID:28254942", "PMID:29326172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023027 ; owl:annotatedTarget "A sst GABAergic cortical interneuron with a soma found in L5 and possesses 'T-shaped' Martinotti morphologies with local axonal plexus in L5a and translaminar axons restricted to the uppermost part of L1. They show low-threshold spiking patterns with strong rebound firing, and inhibit the L1 apical tuft of nearby pyramidal cells." . [] oboInOwl:hasDbXref "PMID:28254942", "PMID:29326172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023028 ; owl:annotatedTarget "A sst GABAergic cortical interneuron with a soma found in lower L5 with mostly local axonal arborization but with some sparse ascending axons. L5 non-Martinotti sst cells show somatic localization and local axon plexus in L5b and L5b/6 and substantial innervation of L3 and L4, and receive thalamic input from the ventral posteromedial nucleus and specifically target L4 neurons, avoiding L5 pyramidal cells. L5 non-Martinotti sst cells tend to show a higher input resistance and seem to be less stuttering." . [] oboInOwl:hasDbXref "PMID:34727523", "WikipediaVersioned:Medium_spiny_neuron&oldid=1109726850" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023029 ; owl:annotatedTarget "A medium spiny neuron that expresses dopamine type 2 receptors and projects to the external globus pallidus." . [] oboInOwl:hasDbXref "PMID:34727523" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023029 ; owl:annotatedTarget "D2-MSN" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-7258-9596" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023029 ; owl:annotatedTarget "dopamine 2 medium spiny neuron" . [] oboInOwl:hasDbXref "PMID:30096299" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023029 ; owl:annotatedTarget "iSPN" . [] oboInOwl:hasDbXref "PMID:27225074", "PMID:27477017", "PMID:28254942", "PMID:29326172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023030 ; owl:annotatedTarget "A sst GABAergic cortical interneuron that has \"fanning-out' Martinotti morphology that is found in layer 2/3/5 of the cerebral cortex. They have local axon arbor and long ascending axons that spreads horizontally and arborizes significantly in L1." . [] oboInOwl:hasDbXref "PMID:33184512" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023030 ; owl:annotatedTarget "L2/3/5 fan Martionotti SST cells have an adapting firing pattern and non-zero afterdepolarization (ADP)." . [] oboInOwl:hasDbXref "PMID:33184512" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023031 ; owl:annotatedTarget "A sst GABAergic cortical interneuron with a soma found in lower L2/3 and upper 5, L4 Sst cells have Martinotti morphology with ascending axons but denser local axons and sparser ‘fanning-out’ projections to L1. L4 sst cells have smaller membrane time constant to calb2 (L2/3/5 fan Martinotti Cell) and non-zero afterdepolarization (ADP)." . [] oboInOwl:hasDbXref "PMID:19602302" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023032 ; owl:annotatedTarget "A retinal ganglion cell that is depolarized by illumination of its receptive field center." . [] oboInOwl:hasDbXref "PMID:19602302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023033 ; owl:annotatedTarget "A retinal ganglion cell that is depolarized by decreased illumination of their receptive field center." . [] oboInOwl:hasDbXref "PMID:33184512" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023034 ; owl:annotatedTarget "OBSOLETE A sst GABAergic cortical interneuron transcriptomically between the sst and the pvalb families with a soma found in L2/3. Some L2/3 PV-like sst cells have Martinotti morphology while some have basket cell morphology. L2/3 PV-like sst cells have lower AP width and higher firing rate than typical Sst subclass cells. L2/3 PV-like sst cells have high maximum firing rate variability, with many classified as belonging to the pvalb subclass on the basis of electrophysiology." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000035 ; owl:annotatedTarget "A stem cell that self-renews as well as give rise to a single mature cell type." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000365 ; owl:annotatedTarget "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." . [] oboInOwl:hasDbXref "wikipediaversioned:Ganglionic_eminence&oldid=1186824360" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023035 ; owl:annotatedTarget "A neuron that is derived from a precursor cell in the lateral ganglion eminence." . [] oboInOwl:hasDbXref "PMID:10377350" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023035 ; owl:annotatedTarget "LGE-derived neuron" . [] oboInOwl:hasDbXref "PMID:27477017", "https://cellxgene.cziscience.com/e/9c63201d-bfd9-41a8-bbbc-18d947556f3d.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023036 ; owl:annotatedTarget "A transcriptomically distinct pvalb GABAergic cortical interneuron that is recognizable by the straight terminal axonal 'cartridges' of vertically oriented strings of synaptic boutons. Chandelier PV cells' boutons target exclusively the axon initial segment (AIS) of pyramidal cells, with a single cell innervating hundreds of pyramidal cells in a clustered manner. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Chandelier." . [] oboInOwl:hasDbXref "PMID:27477017" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023036 ; owl:annotatedTarget "In mice, Chandelier PV cells have soma found in in upper L2/3, with some in deep L5 and exhibit fast-spiking but lower firing rate compared to basket cells, and have practically absent hyperpolarization sag." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023036 ; owl:annotatedTarget "The marker set GPR149, CA8 can identify the Human cell type chandelier pvalb GABAergic cortical interneuron in the neocortex with a confidence of 0.799748111 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000366 ; owl:annotatedTarget "Obsolete. Use PO:0000084 from Plant Ontology instead. Male gamete, part of male germ unit." . [] oboInOwl:hasDbXref "DOI:10.1101/2020.10.19.34312", "PMID:30382198", "PMID:37824655", "https://cellxgene.cziscience.com/e/d01c9dff-abd1-4825-bf30-2eb2ba74597e.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023038 ; owl:annotatedTarget "A glutamatergic neuron with a soma found in cortical layer 6b. They are transcriptomically related to corticothalamic-projecting neurons but have differential projections to the thalamus or anterior cingulate. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neuron', Author Categories: 'CrossArea_subclass', cluster L6b." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023039 ; owl:annotatedTarget "Any neuron that has its soma located in some amygdala and is capable of some glutamate secretion, neurotransmission." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000368 ; owl:annotatedTarget "Obsolete. Use PO:0000352 from Plant Ontology instead. Cell containing glucosinolates ('mustard oil glucosides') and myrosinases, enzymes hydrolyzing the glucosinolates. Occurs in eleven dicotyledon families, the two largest of which are the Brassicaceae and Euphorbiaceae." . [] oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023039 ; owl:annotatedTarget "An excitatory neuron that is located in the amygdala." . [] oboInOwl:hasDbXref "PMID:34616075", "https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023040 ; owl:annotatedTarget "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layers L2/3-6." . [] oboInOwl:hasDbXref "PMID:34616075", "PMID:37824655", "https://cellxgene.cziscience.com/e/d01c9dff-abd1-4825-bf30-2eb2ba74597e.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023041 ; owl:annotatedTarget "A transcriptomically distinct glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons ', Author Categories: 'CrossArea_subclass', clusters L5 ET." . [] oboInOwl:hasDbXref "DOI:10.1016/j.neuron.2005.08.030" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4023041 ; owl:annotatedTarget "subcerebral projection (SCPN) neuron" . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000370 ; owl:annotatedTarget "Obsolete. Use PO:0000078 from Plant Ontology instead. Parenchyma cell with the wall ingrowth (or invaginations) that increase the surface of the plasmalemma. Appears to be specialized for short-distance transfer of solutes." . [] oboInOwl:hasDbXref "PMID:31626774" ; a owl:Axiom ; rdfs:comment "pyramidal tract-like is used because, unlike pyramidal tract neurons in the motor cortex, neurons in the structures like the auditory cortex do not project to the spinal cord." ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023041 ; owl:annotatedTarget "Pyramidal tract-like (PT-l)" . [] oboInOwl:hasDbXref "DOI:10.3389/fncel.2011.00001" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023041 ; owl:annotatedTarget "burst-firing layer 5 neuron" . [] oboInOwl:hasDbXref "DOI:10.3389/fncel.2015.00233" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023041 ; owl:annotatedTarget "thick-tufted layer 5 (TTL5) pyramidal neuron" . [] oboInOwl:hasDbXref "DOI:10.1038/nrn3469" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_4023041 ; owl:annotatedTarget "pyramidal tract (PT) neuron" . [] oboInOwl:hasDbXref "DOI:10.1016/j.neuron.2011.07.029" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023041 ; owl:annotatedTarget "L5b neuron" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023041 ; owl:annotatedTarget "The marker set CHST8, POU3F1 can identify the Human cell type L5 extratelencephalic projecting glutamatergic cortical neuron in the neocortex with a confidence of 0.815891473 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "ISBN:08199377X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000371 ; owl:annotatedTarget "The cell protoplasm after removal of the cell wall." . [] oboInOwl:hasDbXref "PMID:34616075", "PMID:37824655", "https://cellxgene.cziscience.com/e/d01c9dff-abd1-4825-bf30-2eb2ba74597e.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023042 ; owl:annotatedTarget "A transcriptomically distinct corticothalamic-projecting neuron with a soma found in cortical layer 6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons', Author Categories: 'CrossArea_subclass', clusters L6 CT." . [] oboInOwl:hasDbXref "PMID:28625486", "PMID:34616075" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023042 ; owl:annotatedTarget "L6 CT" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023042 ; owl:annotatedTarget "The marker set SEMA5B, ADAMTSL1, SULF1 can identify the Human cell type L6 corticothalamic-projecting glutamatergic cortical neuron in the neocortex with a confidence of 0.631898455 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "ISBN:978-0801481253" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000372 ; owl:annotatedTarget "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization that forms a socket around the base of a cuticular specialization produced by a trichogen cell." . [] oboInOwl:hasDbXref "PMID:31209381", "PMID:34616075", "https://cellxgene.cziscience.com/e/d01c9dff-abd1-4825-bf30-2eb2ba74597e.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023043 ; owl:annotatedTarget "A transcriptomically distinct near-projecting glutamatergic neuron with a soma found in layer 5/6 of the primary motor cortex. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons', Author Categories: 'CrossArea_subclass', cluster L5/6 NP." . [] oboInOwl:hasDbXref "DOI:10.1101/2020.10.19.343129", "PMID:24137110", "PMID:9236245" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023044 ; owl:annotatedTarget "An extratelencephalic-projecting glutamatergic neuron located in layer 5b of the primary motor cortex that does not project to the medulla. Non-MY ET cells are large, big-tufted cells with the apical dendrite often bifurcating close to the soma, suggesting they are corticospinal cells. Non-MY ET cells have bigger hyperpolarization sag, lower input resistance, and smaller AP width, compared to L5 IT neurons." . [] oboInOwl:hasDbXref "DOI:10.1101/2020.10.19.343129", "PMID:24137110", "PMID:9236245" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023045 ; owl:annotatedTarget "An extratelencephalic-projecting glutamatergic neuron located in layer 5b of the primary motor cortex that projects to the medulla. MY ET cells are large, big-tufted cells with the apical dendrite often bifurcating close to the soma, suggesting they are corticospinal cells. MY ET cells have bigger hyperpolarization sag, lower input resistance, and smaller AP width, compared to L5 IT neurons." . [] oboInOwl:hasDbXref "PMID:33184512" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023046 ; owl:annotatedTarget "An excitatory glutamatergic neuron transcriptomically related to the CT subclass, with a soma preferentially located in the bottom of L6 of the primary motor cortex." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023046 ; owl:annotatedTarget "The marker set CCN2, ROS1 can identify the Human cell type L6b glutamatergic neuron of the primary motor cortex in the neocortex with a confidence of 0.819940964 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "ISBN:978-0801481253" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000372 ; owl:annotatedTarget "socket cell" . [] oboInOwl:hasDbXref "PMID:34616075" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023047 ; owl:annotatedTarget "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2/3 of the primary motor cortex." . [] oboInOwl:hasDbXref "PMID:34616075" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023047 ; owl:annotatedTarget "L2/3 IT M1" . [] oboInOwl:hasDbXref "PMID:34616075" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023047 ; owl:annotatedTarget "L2/3 IT MOp" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000372 ; owl:annotatedTarget "FBbt:00005171" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:33184512" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023048 ; owl:annotatedTarget "An intratelencephalic-projecting glutamatergic with a soma located in upper L5 of the primary motor cortex. These cells have thin untufted apical dendrites." . [] oboInOwl:hasDbXref "PMID:33184512" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023049 ; owl:annotatedTarget "An intratelencephalic-projecting glutamatergic neuron with a soma found in L5 of the primary motor cortex." . [] oboInOwl:hasDbXref "PMID:33184512", "PMID:34616063", "PMID:34616075", "PMID:9236245" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023050 ; owl:annotatedTarget "An intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted." . [] oboInOwl:hasDbXref "PMID:27284195", "PMID:29443965", "PMID:30096314", "PMID:37824655", "https://cellxgene.cziscience.com/e/5346f9c6-755e-4336-94cc-38706ec00c2f.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023051 ; owl:annotatedTarget "A transcriptomically distinct type of mesothelial fibroblast that is derived from the neural crest, is localized on blood vessels, and is a key component of the pia and arachnoid membranes surrounding the brain. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Non-neuronal cells', Author Categories: 'CrossArea_subclass', clusters VLMC." . [] oboInOwl:hasDbXref "DOI:10.1101/2020.03.31.016972", "PMID:18558853", "PMID:28751609" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023052 ; owl:annotatedTarget "A Betz cell that synapses with lower motor neurons directly." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2022.01.045" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000373 ; owl:annotatedTarget "A progenitor cell found in the larval epidermis of insects and that gives rise to the adult abdominal epidermis." . [] oboInOwl:hasDbXref "DOI:10.1101/2020.03.31.016972", "PMID:18558853" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023053 ; owl:annotatedTarget "A Betz cell that syanpses with spinal interneurons." . [] oboInOwl:hasDbXref "PMID:26106328" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023054 ; owl:annotatedTarget "A mesothelial cell that has undergone mesothelial-to-mesenchymal transition (MMT) to become a fibroblast cell." . [] oboInOwl:hasDbXref "PMID:20556241", "PMID:9236245" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023055 ; owl:annotatedTarget "A corticothalamic-projecting glutamatergic neuron that is located in L6 and lower L5 of the primary motor cortex, with a pyramidal morphology and mostly untufted apical dendrites terminating in midcortical layers. CT VAL/VM (ventroanterior-ventrolateral complex/ventromedial nucleus) cells have a near tonic firing pattern and are distinguished from L6 IT neurons by a lower inter-spike interval adaptation index." . [] oboInOwl:hasDbXref "PMID:30096314" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_4023056 ; owl:annotatedTarget _:genid14930 . [] oboInOwl:hasDbXref "PMID:30096314" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_4023056 ; owl:annotatedTarget _:genid14932 . [] oboInOwl:hasDbXref "PMID:30096314" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_4023056 ; owl:annotatedTarget _:genid14934 . [] oboInOwl:hasDbXref "PMID:30096314" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023056 ; owl:annotatedTarget "A type of mouse mesothelial fibroblast that is derived from the neural crest, is localized on blood vessels, and is a key component of the pia and arachnoid membranes surrounding the brain." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000035 ; owl:annotatedTarget "ZFA:0009013" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000373 ; owl:annotatedTarget "FBbt:00001789" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023057 ; owl:annotatedTarget "Any GABAergic interneuron that has its soma located in some cerebellar cortex." . [] oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023057 ; owl:annotatedTarget "A GABAergic interneuron whose soma is located in the cerebellar cortex." . [] oboInOwl:hasDbXref "ISBN:978-0801481253" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000374 ; owl:annotatedTarget "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization, often in the form of a hair, bristle, peg or scale. The base of this specialization is often surrounded by a socket produced by a closely associated tormogen cell." . [] oboInOwl:hasDbXref "PMID:32066987" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023059 ; owl:annotatedTarget "An oligodendrocyte precursor cell that is committed to differentiate." . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023059 ; owl:annotatedTarget "COP" . [] oboInOwl:hasDbXref "PMID:27284195" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023059 ; owl:annotatedTarget "COPs are distinct from OPCs in that the lack expression of Pdgfra and Cspg4 and come out as distinct clusters in transcriptomic profiling. This is the reason that this term is not modelled as a subclassOf OPC but instead linked using develops_from." . [] oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023060 ; owl:annotatedTarget "A neuron that has its soma located in CA1-3 of the hippocampus." . [] oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023061 ; owl:annotatedTarget "A neuron that has its soma located in CA4 of the hippocampus." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000374 ; owl:annotatedTarget "FBbt:00005169" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023063 ; owl:annotatedTarget "An interneuron that is derived from the medial ganglionic eminence." . [] oboInOwl:hasDbXref "PMID:20130169", "PMID:37824655", "PMID:37824663" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023064 ; owl:annotatedTarget "An interneuron that is derived from the caudal ganglionic eminence." . [] oboInOwl:hasDbXref "PMID:20130169" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023064 ; owl:annotatedTarget "caudal ganglionic eminence derived GABAergic cortical interneuron" . [] oboInOwl:hasDbXref "PMID:20130169" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023064 ; owl:annotatedTarget "CGE cortical interneuron" . [] oboInOwl:hasDbXref "PMID:37824663" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023064 ; owl:annotatedTarget "CGE interneuron" . [] oboInOwl:hasDbXref "PMID:27034423" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023064 ; owl:annotatedTarget "CGE-derived GABAergic IN" . [] oboInOwl:hasDbXref "PMID:27034423" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023064 ; owl:annotatedTarget "CGE-derived cell" . [] oboInOwl:hasDbXref "PMID:20130169", "PMID:37824655" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023064 ; owl:annotatedTarget "CGE-derived interneuron" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000379 ; owl:annotatedTarget "ZFA:0009185" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:33372656" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023065 ; owl:annotatedTarget "A GABAergic cell located in the cerebral cortex that expresses meis2." . [] oboInOwl:hasDbXref "PMID:30715238" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023066 ; owl:annotatedTarget "A pyramidal neuron which has an apical tree which is oriented parallel to the pia. This is unlike typical pyramidal neurons which have its apical dendrite aligned vertically." . [] oboInOwl:hasDbXref "PMID:33184512" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023067 ; owl:annotatedTarget "OBSOLETE A L2/3 pvalb-like sst GABAergic cortical interneuron (Mus musculus) that has Martinotti morphology." . [] oboInOwl:hasDbXref "Fbbt:00005173" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000380 ; owl:annotatedTarget "The support cell that makes the thecogen dendritic cap - a cuticle-like matrix around the tip of the eo-dendrite and which encloses the soma of the eo-neuron." . [] oboInOwl:hasDbXref "PMID:30083593", "PMID:31196673", "PMID:35278647", "PMID:37163009", "PMID:37824663", "PMID:38739251" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023068 ; owl:annotatedTarget "An excitatory neuron that has its soma located in the thalamic complex. This neuron type can be involved in a series of circuits related to sensory integration, motor integration, pain processing, social behaviour and reward response." . [] oboInOwl:hasDbXref "PMID:11532718", "PMID:30083593", "PMID:38739251" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023068 ; owl:annotatedTarget "Abnormalities in glutametergic neurons of the thalamic complex are associated with pathologies such as schizophrenia, colorectal visceral pain and Parkinson's disease." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000380 ; owl:annotatedTarget "FBbt:00005173" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:12637172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023069 ; owl:annotatedTarget "A GABAergic cortical interneuron that develops from the medial ganglionic eminence and has migrated to the cerebral cortex." . [] oboInOwl:hasDbXref "PMID:20130169" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023070 ; owl:annotatedTarget "OBSOLETE. A GABAergic cortical interneuron that develops from the caudal ganglionic eminence and has migrated to the cerebral cortex." . [] oboInOwl:hasDbXref "PMID:33184512" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023071 ; owl:annotatedTarget "A GABAergic cortical interneuron that expresses cck. L5/6 cck cells have soma found mainly in L5 and L6 and have large axonal arborization." . [] oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023072 ; owl:annotatedTarget "A cell that is part of the brain vasculature." . [] oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023073 ; owl:annotatedTarget "OBSOLETE. A cell that is part of the choroid plexus." . [] oboInOwl:hasDbXref "doi:10.1016/B978-012369493-5.50012-2", "doi:10.1017/CBO9780511818202.024" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000382 ; owl:annotatedTarget "A cell that is part of a scolopidium and surrounds the dendrite of a scolopidial neuron." . [] oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023074 ; owl:annotatedTarget "A neuron that has its soma located in the mammillary body." . [] oboInOwl:hasDbXref "PMID:22357664" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023075 ; owl:annotatedTarget "A sst GABAergic cortical interneuron found in L6 that expresses tyrosine hydroxylase. L6 Th+ SST cells have mostly local axonal arborization within L6." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000382 ; owl:annotatedTarget "FBbt:00005219" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "WikipediaVersioned:Martinotti_cell&oldid=9947732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023076 ; owl:annotatedTarget "An interneuron that has Martinotti morphology. These interneurons are scattered throughout various layers of the cerebral cortex, sending their axons up to the cortical layer I where they form axonal arborization." . [] oboInOwl:hasDbXref "ISBN:978-087969828-7" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000382 ; owl:annotatedTarget "scolopidial sheath cell" . [] oboInOwl:hasDbXref "PMID:18568015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023077 ; owl:annotatedTarget "A type of interneuron that has two clusters of dendritic branches that originate directly from the soma and extend in opposite directions and axons that form a plexus which spreads widely. Compared to bipolar neurons, bitufted neurons have branching that occur close to the soma." . [] obo:IAO_0000116 "Interlex cross reference refers specifically to Markram 2015 rat bitufted cell." ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_4023077 ; owl:annotatedTarget "ILX:0777212" . [] oboInOwl:hasDbXref "PMID:33184512" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023078 ; owl:annotatedTarget "OBSOLETE A L2/3 pvalb-like sst GABAergic cortical interneuron (Mus musculus) that has basket morphology." . [] oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023079 ; owl:annotatedTarget "A GABAergic inhibitory neuron that is derived from the midbrain." . [] oboInOwl:hasDbXref "PMID:9236245" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023080 ; owl:annotatedTarget "a L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex that has stellate pyramidal morphology." . [] oboInOwl:hasDbXref "PMID:9236245" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023081 ; owl:annotatedTarget "a L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex that has inverted pyramidal morphology." . [] oboInOwl:hasDbXref "PMID:15378039", "PMID:27199673", "PMID:37824655" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023083 ; owl:annotatedTarget "A GABAergic interneuron that selectively innervates the axon initial segment of pyramidal cells. Their local axonal clusters are formed by high-frequency branching at shallow angles, often ramifying around, above or below their somata with a high bouton density. The characteristic terminal portions of the axon form short vertical rows of boutons, resembling the candlesticks and candles of a chandelier. Chandelier cells can be multipolar or bitufted." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000383 ; owl:annotatedTarget "ZFA:0009187" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:27199673", "PMID:33862423" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4023083 ; owl:annotatedTarget "axo-axonic cell" . [] obo:IAO_0000116 "Interlex cross reference refers specifically to Markram 2015 rat chandelier cell." ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_4023083 ; owl:annotatedTarget "ILX:0777213" . [] oboInOwl:hasDbXref "PMID:15378039" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023083 ; owl:annotatedTarget "ChC" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000384 ; owl:annotatedTarget "ZFA:0009188" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "doi:10.1016/b978-0-12-369497-3.10004-4" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023086 ; owl:annotatedTarget "A Martinotti neuron that has axons that form a horizontal ramification, making it T-shaped." . [] oboInOwl:hasDbXref "doi:10.1016/b978-0-12-369497-3.10004-4" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023087 ; owl:annotatedTarget "A Martinotti neuron that has axons that form a fan-like plexus." . [] oboInOwl:hasDbXref "doi:10.1016/B978-012369493-5.50008-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000385 ; owl:annotatedTarget "A precursor of mature hemocytes." . [] oboInOwl:hasDbXref "PMID:11884355" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023088 ; owl:annotatedTarget "A basket cell that is large, and typically ascends to give rise to many long horizontally and vertically projecting axon collaterals that traverse neighboring columns and can extend through all cortical layers." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000385 ; owl:annotatedTarget "FBbt:00005062" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:11884355" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023089 ; owl:annotatedTarget "A basket cell which has simpler dendritic arbors (compared to small or large basket cells), and an axonal plexus of intermediate density, composed of a few long, smooth axonal branches." . [] oboInOwl:hasDbXref "PMID:11884355" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023090 ; owl:annotatedTarget "A basket cell with axonal arbors composed of frequent, short, curvy axonal branches that tend to be near their somata and within the same layer." . [] oboInOwl:hasDbXref "PMID:30715238" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023092 ; owl:annotatedTarget "A pyramidal neuron which has an apical tree which is oriented towards the white matter." . [] oboInOwl:hasDbXref "doi:10.1016/B978-012369493-5.50008-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000387 ; owl:annotatedTarget "A blood cell of the circulatory system of arthropods." . [] oboInOwl:hasDbXref "PMID:30715238" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023093 ; owl:annotatedTarget "A pyramidal neuron which lacks a tuft formation but extends small radial distances forming a star-like shape." . [] oboInOwl:hasDbXref "PMID:30715238" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023094 ; owl:annotatedTarget "A pyramidal neuron which has a distinctive tuft formation, distal from the soma." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000387 ; owl:annotatedTarget "FBbt:00005063" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:30715238" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023095 ; owl:annotatedTarget "A pyramidal neuron which lacks a clear tuft formation but extends to large radial distances." . [] oboInOwl:hasDbXref "PMID:23298861" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023097 ; owl:annotatedTarget "A mesothelial fibroblast of the arachnoid barrier layer. Arachnoid barrier cells make up the tight-junctioned layer in the leptomeninx that functions as the physiologic barrier between the cerebrospinal fluid in the subarachnoid space and the fenestrated capillaries in the dura." . [] oboInOwl:hasDbXref "PMID:23298861" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023097 ; owl:annotatedTarget "AB cell" . [] oboInOwl:hasDbXref "PMID:30096314" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023097 ; owl:annotatedTarget "ABC" . [] oboInOwl:hasDbXref "DOI:10.1101/2020.03.31.016972" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023098 ; owl:annotatedTarget "OBSOLETE An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 2/3 of the human primary motor cortex." . [] oboInOwl:hasDbXref "DOI:10.1101/2020.03.31.016972" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023099 ; owl:annotatedTarget "OBSOLETE. An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 5 of the human primary motor cortex." . [] oboInOwl:hasDbXref "DOI:10.1101/2020.03.31.016972" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023100 ; owl:annotatedTarget "OBSOLETE. An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 6 of the human primary motor cortex." . [] oboInOwl:hasDbXref "DOI:10.1101/2020.03.31.016972" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023101 ; owl:annotatedTarget "OBSOLETE. A near-projecting glutamatergic neuron with a soma found in layer 5/6 of the human primary motor cortex." . [] oboInOwl:hasDbXref "DOI:10.1101/2020.03.31.016972" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023102 ; owl:annotatedTarget "OBSOLETE. A near-projecting glutamatergic neuron with a soma found in layer 5/6 of the marmoset primary motor cortex." . [] oboInOwl:hasDbXref "DOI:10.1101/2020.03.31.016972" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023103 ; owl:annotatedTarget "OBSOLETE. An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 2/3 of the marmoset primary motor cortex." . [] oboInOwl:hasDbXref "DOI:10.1101/2020.03.31.016972" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023104 ; owl:annotatedTarget "OBSOLETE An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 5 of the marmoset primary motor cortex." . [] oboInOwl:hasDbXref "DOI:10.1101/2020.03.31.016972" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023105 ; owl:annotatedTarget "OBSOLETE. An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 6 of the marmoset primary motor cortex." . [] oboInOwl:hasDbXref "DOI:10.1101/2020.03.31.016972" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023106 ; owl:annotatedTarget "OBSOLETE. A mouse GABAergic cell located in the marmoset cerebral cortex that expresses meis2." . [] oboInOwl:hasDbXref "PMID:29720934" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023107 ; owl:annotatedTarget "A neuron with soma location in the reticular formation with axons that extend into the spinal cord such. Reticulospinal neuron activity can lead to a variety of motor behaviors." . [] oboInOwl:hasDbXref "PMID:29720934" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023107 ; owl:annotatedTarget "RSN" . [] oboInOwl:hasDbXref "WikipediaVersioned:Magnocellular_neurosecretory_cell&oldid=1021059931" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023108 ; owl:annotatedTarget "A magnocellular neurosecretory cell that is capable of producing and secreting oxytocin." . [] oboInOwl:hasDbXref "WikipediaVersioned:Magnocellular_neurosecretory_cell&oldid=1021059931" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023109 ; owl:annotatedTarget "A magnocellular neurosecretory cell that is capable of producing and secreting vasopressin." . [] oboInOwl:hasDbXref "PMID:1375860" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023110 ; owl:annotatedTarget "A pyramidal neuron with soma located in the amygdala." . [] oboInOwl:hasDbXref "PMID:30715238" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023111 ; owl:annotatedTarget "A pyramidal neuron with soma located in the cerebral cortex." . [] oboInOwl:hasDbXref "PMID:2585041" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023112 ; owl:annotatedTarget "An afferent neuron of the vestibular system that innervate the base of the hair cell and increase or decrease their neural firing rate as the receptor cell is excited or inhibited." . [] oboInOwl:hasDbXref "PMID:10706428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023113 ; owl:annotatedTarget "A vestibular afferent neuron that makes bouton synapses to type II hair cells." . [] oboInOwl:hasDbXref "PMID:25355208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023114 ; owl:annotatedTarget "A vestibular afferent neuron which posseses a unique postsynaptic terminal, the calyx, which completely covers the basolateral walls of type I hair cells and receives input from multiple ribbon synapses." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000388 ; owl:annotatedTarget obo:CL_0000135 . [] oboInOwl:hasDbXref "WikipediaVersioned:Spiral_ganglion&oldid=994446209" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023115 ; owl:annotatedTarget "A spiral ganglion neuron that innervates inner hair cells. Type 1 spiral ganglion neurons are myelinated and bipolar." . [] oboInOwl:hasDbXref "WikipediaVersioned:Spiral_ganglion&oldid=994446209" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023115 ; owl:annotatedTarget "Type 1 spiral ganglion neurons comprise the vast majority of spiral ganglion cells." . [] oboInOwl:hasDbXref "GOC:NV", "GOC:tfm", "PMID:957445" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000388 ; owl:annotatedTarget "An elongated fibrocyte that is part of a tendon. The cytoplasm is stretched between the collagen fibres of the tendon. They have a central cell nucleus with a prominent nucleolus. Tendon cells have a well-developed rough endoplasmic reticulum and they are responsible for synthesis and turnover of tendon fibres and ground substance." . [] oboInOwl:hasDbXref "WikipediaVersioned:Spiral_ganglion&oldid=994446209" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023116 ; owl:annotatedTarget "A spiral ganglion neuron that innervates outer hair cells. Type 1 spiral ganglion neurons are unmyelinated and unipolar." . [] oboInOwl:hasDbXref "WikipediaVersioned:Spiral_ganglion&oldid=994446209" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023116 ; owl:annotatedTarget "Outer hair cells form reciprocal synapses onto type 2 spiral ganglion cells, suggesting that the type 2 cells have both afferent and efferent roles." . [] oboInOwl:hasDbXref "PMID:27477017" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023118 ; owl:annotatedTarget "A sst GABAergic interneuron does not have Martinotti morphology with a soma found in L5/6 of the cerebral cortex." . [] oboInOwl:hasDbXref "PMID:27477017" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023118 ; owl:annotatedTarget "L5/6 non-Martinotti SST cells have strongly facilitating excitatory inputs and moderately depressing outputs. They have faster action potential than Martinotti morphology SST cells and slightly slower than PV basket cells." . [] oboInOwl:hasDbXref "PMID:21557506", "PMID:67960" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023119 ; owl:annotatedTarget "A subpopulation of amacrine cell that migrate further than other amacrine cells, and come to lie basal to the inner plexiform layer (IPL) in the ganglion cell layer. Displaced amacrine cells still have their neurites extending apically into the IPL, and therefore exhibit an inverted polarity with respect to the other amacrine cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000388 ; owl:annotatedTarget "ZFA:0009189" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:18719084" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023119 ; owl:annotatedTarget "Displaced amacrine cells are a subset of Sox2 expressing amacrine cells." . [] oboInOwl:hasDbXref "Wikipedia:Hair_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023120 ; owl:annotatedTarget "An auditory hair cell found in the cochlea." . [] oboInOwl:hasDbXref "PMID:15845086", "PMID:31209381", "PMID:33372656", "PMID:37824655", "https://cellxgene.cziscience.com/e/9c63201d-bfd9-41a8-bbbc-18d947556f3d.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023121 ; owl:annotatedTarget "A transcriptomically distinct sst GABAergic cortical interneuron that also expresses Chodl. These neurons are rare and correspond to the only known cortical interneurons with long-range projection. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Sst Chodl." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023121 ; owl:annotatedTarget "The marker set NPY can identify the Human cell type sst chodl GABAergic cortical interneuron in the neocortex with a confidence of 0.894026187 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "PMID:25303526" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023122 ; owl:annotatedTarget "An interneuron located in the cerebral cortex that expresses the oxytocin receptor. These interneurons also express somatostatin." . [] oboInOwl:hasDbXref "PMID:25303526" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002175 ; owl:annotatedSource obo:CL_4023122 ; owl:annotatedTarget obo:NCBITaxon_10090 . [] oboInOwl:hasDbXref "PMID:25303526" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023122 ; owl:annotatedTarget "OxtrINs" . [] oboInOwl:hasDbXref "PMID:25303526" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023122 ; owl:annotatedTarget "These cells were first identified in mouse." . [] oboInOwl:hasDbXref "doi:10.1016/B978-012369493-5.50008-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000392 ; owl:annotatedTarget "A hemocyte that synthesizes and secretes melanins as part of the antimicrobial immune response. It is characterized morphologically by crystal inclusions of phenoloxidases in its cytoplasm, hence its name." . [] oboInOwl:hasDbXref "PMID:30042117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023123 ; owl:annotatedTarget "A kisspeptin neuron that is located in the hypothalamus. These neurons project to and activate gonadotrophin-releasing hormone neurons (acting via the kisspeptin receptor) in the hypothalamus and stimulate the secretion of gonadotrophin-releasing hormone." . [] oboInOwl:hasDbXref "WikipediaVersioned:Kisspeptin&oldid=1042853037" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023124 ; owl:annotatedTarget "A kisspeptin neuron that is located in the dentate gyrus of the hippocampus." . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000393 ; owl:annotatedTarget "A cell whose function is determined by its response to an electric signal." . [] oboInOwl:hasDbXref "WikipediaVersioned:KNDy_neuron&oldid=964682278" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023125 ; owl:annotatedTarget "A hypothalamus kisspeptin neuron that coexpresses kisspeptin, neurokinin B and dynorphin." . [] oboInOwl:hasDbXref "WikipediaVersioned:KNDy_neuron&oldid=964682278" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023125 ; owl:annotatedTarget "KNDy neurons are involved in the negative feedback of gonadotropin-releasing hormone release in the hypothalamic–pituitary–gonadal axis. Sex steroids released from the gonads act on KNDy neurons as inhibitors of kisspeptin release. This inhibition provides negative feedback control on the hypothalamic–pituitary–gonadal axis. Other roles of KNDy neurons include influences on prolactin production; puberty; stress' effects on reproduction; and the control of thermoregulation." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000393 ; owl:annotatedTarget "ZFA:0009190" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:30042117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023127 ; owl:annotatedTarget "a KNDy neuron that is located in the arcuate nucleus of the hypothalamus." . [] oboInOwl:hasDbXref "PMID:30042117", "WikipediaVersioned:KNDy_neuron&oldid=964682278" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023128 ; owl:annotatedTarget "a KNDy neuron that is located in the rostral periventricular region of the third ventricle." . [] oboInOwl:hasDbXref "WikipediaVersioned:Anteroventral_periventricular_nucleus&oldid=966137187" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:CL_4023128 ; owl:annotatedTarget "In rats and mice, the anteroventral periventricular nucleus plus the periventricular nucleus make up the rostral periventricular region of the third ventricle (RP3V)." . [] oboInOwl:hasDbXref "PMID:17565741" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023129 ; owl:annotatedTarget "A retinal cell that is immature or undifferentiated." . [] oboInOwl:hasDbXref "PMID:17565741" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023129 ; owl:annotatedTarget "retinal stem cell" . [] oboInOwl:hasDbXref "PMID:30042117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023130 ; owl:annotatedTarget "A neuron that expresses kisspeptin. These neurons are predominantly located in the hypothalamus, but also found in other parts of the brain including the hippocampal dentate gyrus." . [] oboInOwl:hasDbXref "https://doi.org/10.1016/B978-012369493-5.50008-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000394 ; owl:annotatedTarget "A phagocytic hemocyte, responsible for the engulfment of small particles, microbes, and apoptotic tissue debris. It may also secretes antimicrobial peptides and contribute to the production and secretion of proteins of the hemolymph." . [] oboInOwl:hasDbXref "PMID:30042117" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023130 ; owl:annotatedTarget "Gonadal sex steroids stimulate kisspeptin neurons in the RP3V, but inhibit kisspeptin neurons in the ARC." . [] oboInOwl:hasDbXref "DOI:10.1007/3-540-29623-9_3240" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023154 ; owl:annotatedTarget "A glial cell that myelinates axonal processes." . [] oboInOwl:hasDbXref "WikipediaVersioned:title=Cochlear_nucleus&oldid=1090176664" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023158 ; owl:annotatedTarget "A neuron in the posterior ventral cochlear nucleus that is distinguished by their long, thick and tentacle-shaped dendrites that typically emanate from one side of the cell body." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000394 ; owl:annotatedTarget "FBbt:00001685" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:11976365", "WikipediaVersioned:title=Cochlear_nucleus&oldid=1090176664" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023158 ; owl:annotatedTarget "Octopus cells respond only at the onset of a broad-band simple tonal stimulus and form a pathway to the superior paraolivary nucleus and to the ventral nucleus of the lateral lemniscus." . [] oboInOwl:hasDbXref "PMID:15378039" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023159 ; owl:annotatedTarget "An interneuron that has double bouquet morphology." . [] oboInOwl:hasDbXref "ILX:0102311", "WikipediaVersioned:Cartwheel_cell&oldid=1040398094" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023160 ; owl:annotatedTarget "A neuron of the dorsal cochlear nucleus with spiny dendrites that receive input from the axons of granule cells and with axons that release GABA and glycine onto cartwheel, pyramidal and giant cell targets." . [] oboInOwl:hasDbXref "doi:10.1016/B978-012369493-5.50008-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000395 ; owl:annotatedTarget "A precursor of mature crystal cells." . [] oboInOwl:hasDbXref "ILX:0102311" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023160 ; owl:annotatedTarget "Cartwheel cells share many of the features, molecular and electrophysiological, of cerebellar Purkinje neurons." . [] oboInOwl:hasDbXref "PMID:9193142", "WikipediaVersioned:Unipolar_brush_cell&oldid=1045937026" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023161 ; owl:annotatedTarget "An excitatory glutamatergic interneuron found in the granular layer of the cerebellar cortex and also in the granule cell domain of the cochlear nucleus. Unipolar brush cells have a round or oval cell body with usually a single short dendrite that ends in a brush-like tuft of short dendrites unique to them known as dendrioles." . [] dc:license ; oboInOwl:hasDbXref "doi:10.1016/j.cnp.2022.11.002" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4023161 ; owl:annotatedTarget . [] dc:license ; oboInOwl:hasDbXref "doi:10.3389/fnins.2020.00293" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4023161 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "WikipediaVersioned:Bushy_cell&oldid=879061753" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023162 ; owl:annotatedTarget "A neuron found in the anterior part of the ventral cochlear nucleus that has the appearance of bushes, having short dendrites. Bushy cells give outputs to different parts of the superior olivary complex." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000395 ; owl:annotatedTarget "FBbt:00001689" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:31881018", "WikipediaVersioned:Bushy_cell&oldid=879061753" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023163 ; owl:annotatedTarget "A bushy cell that receives only few large excitatory endbulb synapses from auditory nerves. Spherical bush cells give excitatory input to the lateral and medial parts of the superior olive." . [] oboInOwl:hasDbXref "PMID:31881018" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4023163 ; owl:annotatedTarget "SBC" . [] oboInOwl:hasDbXref "PMID:31881018", "WikipediaVersioned:Bushy_cell&oldid=879061753" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023164 ; owl:annotatedTarget "A bushy cell that receives a large number of medium-sized synapses, called modified endbulbs. Globular bushy cells extend to the superior olive on both sides of the brainstem where they give input to the bipolar neurons." . [] oboInOwl:hasDbXref "PMID:31881018" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023164 ; owl:annotatedTarget "GBC" . [] oboInOwl:hasDbXref "doi:10.1016/B978-012369493-5.50008-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000396 ; owl:annotatedTarget "A hemocyte found in immuno-stimulated larvae." . [] oboInOwl:hasDbXref "PMID:22865660" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023168 ; owl:annotatedTarget "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli." . [] oboInOwl:hasDbXref "PMID:22190641", "WikipediaVersioned:Trigeminal_nerve&oldid=1099897926" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023169 ; owl:annotatedTarget "A neuron that is responsible for sensation in the face or motor functions such as biting and chewing. Trigeminal neurons extend a single axon shaft along the lateral white matter of the hindbrain and spinal cord. The highly branched axons innervate the integument of the head." . [] oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK539823/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023170 ; owl:annotatedTarget "A trigeminal neuron that is responsible for sensation in the face." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000396 ; owl:annotatedTarget "FBbt:00001687" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK539823/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023171 ; owl:annotatedTarget "A trigeminal neuron that is responsible for motor functions such as biting and chewing." . [] oboInOwl:hasDbXref , "PMID:26778959", "PMID:9579598" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023181 ; owl:annotatedTarget "A neurecto-epithelial cell that is part of the basal layer of the subcommissural organ and specializes in the secretion of proteins into the subarachnoid space. Hypendymal cells have similar characteristics to ependymal cells and express SCO-spondin." . [] oboInOwl:hasDbXref "DOI:10.1002/(SICI)1097-0029(19980415)41:2<98::AID-JEMT2>3.0.CO;2-M", "DOI:10.1111/joa.13709", "DOI:10.3389/fncel.2015.00480" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_4023181 ; owl:annotatedTarget """Hypendymal cells are secretory cells located between the ependymal layer and the posterior commissure, forming the hypendmal layer of the subcommissural organ (SCO), a highly conserved gland that is part of the circumventricular system within the brain. Hypendymal cells are bipolar cells with a thin apical pole and basal process. Most of the ultrastructural characteristics of these cells are similar to those described for the ependymal cells (which are arranged into another layer – the ependyma). However, ependymal cells release their secretion into the ventricular cerebrospinal fluid whereas hypendymal cells project processes to the local blood vessels and to the subarachnoidal space. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "hypendymal cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4023181 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_4023181" . [] oboInOwl:hasDbXref "WikipediaVersioned:Lateral_geniculate_nucleus&oldid=1098375993" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023187 ; owl:annotatedTarget "A neuron with a small cell body that is located in a koniocellular layer of the lateral geniculate nucleus (LGN)." . [] oboInOwl:hasDbXref "PMID:10845061" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4023187 ; owl:annotatedTarget "K cell" . [] oboInOwl:hasDbXref "PMID:10845061" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023187 ; owl:annotatedTarget "In adult monkeys, koniocellular cells can be distinguished from parvocellular and magnocellular of the LGN by their expression of calbindin, the alpha subunit of type II calmodulin-dependent protein kinase, and the gamma subunit of protein kinase C." . [] oboInOwl:hasDbXref "PMID:32533915", "WikipediaVersioned:Midget_cell&oldid=982299713" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023188 ; owl:annotatedTarget "A retinal ganglion cell that originate in the ganglion cell layer of the retina, and project to the parvocellular layers of the lateral geniculate nucleus (LGN). These cells are known as midget retinal ganglion cells due to the small sizes of their dendritic trees and cell bodies." . [] oboInOwl:hasDbXref "PMID:32533915", "WikipediaVersioned:Parasol_cell&oldid=1032171532" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023189 ; owl:annotatedTarget "A retinal ganglion cell located in the ganglion cell layer of the retina. This cell projects to magnocellular cells in the lateral geniculate nucleus (LGN). They have large cell bodies and extensive, branching dendritic networks that contribute to their large receptive fields." . [] oboInOwl:hasDbXref "PMID:31233341", "PMID:32059772", "PMID:32059779", "PMID:32091393", "PMID:33057196", "PMID:33705684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4028002 ; owl:annotatedTarget "An alveolar capillary endothelial cell that is located distally to alveolar capillary type 2 endothelial cells." . [] oboInOwl:hasDbXref "PMID:33057196" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4028002 ; owl:annotatedTarget "general capillary cell" . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4028002 ; owl:annotatedTarget "CAP1" . [] oboInOwl:hasDbXref "PMID:33057196" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4028002 ; owl:annotatedTarget "gCAP" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM558.BZLS.992" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4028002 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" . [] oboInOwl:hasDbXref "PMID:31233341", "PMID:32059772", "PMID:32059779", "PMID:32091393", "PMID:33057196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4028003 ; owl:annotatedTarget "An alveolar capillary endothelial cell that is located proximally to alveolar capillary type 1 endothelial cells and in close apposition to alveolar type 1 epithelial cells (also known as type I pneumocytes)." . [] oboInOwl:hasDbXref "PMID:33057196" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4028003 ; owl:annotatedTarget "aerocyte" . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4028003 ; owl:annotatedTarget "aCAP" . [] oboInOwl:hasDbXref "PMID:22268140", "PMID:26706109", "PMID:28886382", "PMID:29489752", "PMID:30675802", "PMID:33624948", "PMID:33707239", "PMID:9074756" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4028004 ; owl:annotatedTarget "A pulmonary interstitial fibroblast that is part of the alveolus and contains lipid droplets." . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4028004 ; owl:annotatedTarget "AF1" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4028004 ; owl:annotatedTarget "The marker set AOC3, LUM can identify the Human cell type alveolar type 1 fibroblast cell in the lung with a confidence of 0.70 (NS-Forest FBeta value)." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM558.BZLS.992" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4028004 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" . [] oboInOwl:hasDbXref "PMID:26706109", "PMID:28886382", "PMID:29752282", "PMID:30675802", "PMID:33208946", "PMID:33624948" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4028006 ; owl:annotatedTarget "A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia." . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4028006 ; owl:annotatedTarget "AF2" . [] oboInOwl:hasDbXref "PMID:33208946" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4028006 ; owl:annotatedTarget "AdvF" . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4028006 ; owl:annotatedTarget "MANC" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4028006 ; owl:annotatedTarget "The marker set SCARA5, CD248 can identify the Human cell type alveolar adventitial fibroblast in the lung with a confidence of 0.85 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "doi:10.1016/bs.ctdb.2020.10.008" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4029001 ; owl:annotatedTarget "A cell that supports the development of a gamete by providing it cytoplasmic material (including entire organelles) by direct cross-membrane channels (del Pino, 2021)." . [] oboInOwl:hasDbXref "doi:10.1016/bs.ctdb.2020.10.008" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4029002 ; owl:annotatedTarget "A gamete-nursing cell that derives from a germline cell (del Pino, 2021)." . [] oboInOwl:hasDbXref "doi:10.1126/science.aad2156" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4029002 ; owl:annotatedTarget "Nurse cells were first described in insects, but recent works suggest they also exist in some mammals (Lei and Spradling, 2016)." . [] oboInOwl:hasDbXref "doi:10.1016/bs.ctdb.2020.10.008" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4029003 ; owl:annotatedTarget "A gamete-nursing cell that derives from the somatic tissues of the gonad (del Pino, 2021)." . [] oboInOwl:hasDbXref "doi:10.1111/andr.12165" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4029003 ; owl:annotatedTarget "We follow what seems to be a common usage in the literature, which is to reserve the term “nurse cell” proper to cells from the germ line, hence the label “nurse-like”. This term encompasses pyriform cells described in reptiles, bird, and amphibians (del Pino, 2021); it does not encompass mammalian Sertoli cells, which do not appear to transfer cytoplasmic material to spermatogonia (França et al., 2016)." . [] oboInOwl:hasDbXref "PMID:31819095", "http://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030000 ; owl:annotatedTarget "A melanocyte located in the vascular uvea and involved in photoprotection, regulation of oxidative damage and immune responses." . [] oboInOwl:hasDbXref "PMID:31819095", "PMID:34082079" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030000 ; owl:annotatedTarget "Cellular functions and extracellular interactions of choroidal melanocytes are distinct to skin melanocytes. They might have both neuroectodermal as well as mesectodermal origins." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000397 ; owl:annotatedTarget obo:CL_0000099 . [] oboInOwl:hasDbXref "doi:10.1038/s41467-020-20082-7" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030001 ; owl:annotatedTarget "A stromal cell that is part of the thymus." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-2825-0621" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030002 ; owl:annotatedTarget "An alpha-beta memory T cell with the phenotype CD45RA-positive." . [] oboInOwl:hasDbXref "PMID:16237082" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4030002 ; owl:annotatedTarget "TEMRA" . [] oboInOwl:hasDbXref "PMID:16237082" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4030002 ; owl:annotatedTarget "effector memory RA T cell" . [] oboInOwl:hasDbXref "PMID:25104859" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030002 ; owl:annotatedTarget "TEMRA cell" . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000397 ; owl:annotatedTarget "Any interneuron that has its soma located in some ganglion." . [] oboInOwl:hasDbXref "PMID:25104859" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030002 ; owl:annotatedTarget "terminally differentiated effector memory CD45RA+ T cells" . [] oboInOwl:hasDbXref "https://en.wikipedia.org/wiki/T_cell#Memory_T_cells" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030002 ; owl:annotatedTarget "terminally differentiated effector memory cells re-expressing CD45RA" . [] oboInOwl:hasDbXref "doi:10.1038/s41467-020-20082-7" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030003 ; owl:annotatedTarget "A cell that makes up the loose connective tissue of the thymus." . [] oboInOwl:hasDbXref "https://en.wikipedia.org/wiki/Thymic_nurse_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030004 ; owl:annotatedTarget "A large epithelial cell found in the thymus. This cell type may internalize thymocytes through extensions of plasma membrane. The cell surface and cytoplasmic vacuoles of a thymic nurse cell express MHC Class I and MHC Class II antigens. The interaction of these antigens with a developing thymocyte determines whether the thymocyte undergoes positive or negative selection." . [] oboInOwl:hasDbXref "PMID:24051376", "PMID:31300091", "PMID:32016094" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030005 ; owl:annotatedTarget "A renal beta-intercalated cell that is part of the cortical collecting duct. The medullary collecting duct does not contain the renal beta-intercalated cell type." . [] oboInOwl:hasDbXref "PMID:32016094" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030005 ; owl:annotatedTarget "B-IC" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000399 ; owl:annotatedTarget "Obsolete. Consult Plant Ontology instead. OBSOLETED, not defined prior to obsoletion." . [] oboInOwl:hasDbXref "PMID:31300091" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030005 ; owl:annotatedTarget "kidney collecting duct intercalated cell type B" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM483.MXQP.399" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4030005 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-cortical-collecting-duct/v1.3/assets/2d-ftu-kidney-cortical-collecting-duct.png" . [] oboInOwl:hasDbXref "https://doi.org/10.1186/1477-7827-7-129", "https://doi.org/10.3390/cells8080933", "https://www.proteinatlas.org/learn/dictionary/normal/fallopian+tube" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030006 ; owl:annotatedTarget "An epithelial cell that is part of the fallopian tube that secretes mucus and oviduct-specific products in response to hormonal stimulation from estrogen and luteinizing hormone. This fallopian tube secretory cell is similar in height to the ciliated cell, but typically exhibits a more narrow, columnar shape. Its nucleus is ovoid and oriented perpendicular to the cell's long axis, with denser chromatin and a smaller nucleolus compared to the ciliated cell." . [] oboInOwl:hasDbXref "https://doi.org/10.1016/j.ccr.2013.10.013", "https://www.proteinatlas.org/learn/dictionary/normal/fallopian+tube" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030006 ; owl:annotatedTarget "The other cell types of the fallopian tube epithelium include the ciliated cell and the intercalary cell, or peg cell. The fallopian tube secretory epithelial cell type has been implicated as a source of high-grade serous ovarian carcinoma." . [] oboInOwl:hasDbXref "PMID:16565155", "https://www.proteinatlas.org/humanproteome/tissue/fallopian+tube" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030007 ; owl:annotatedTarget "A multi-ciliated epithelial cell that is part of the fallopian tube, mainly found on the apex of the mucosal folds. This cell exhibits a columnar shape with an oval nucleus and is characterized by the presence of cilia on its surface. The coordinated beating of these cilia, together with peristaltic contractions, contributes to the self-propulsion of spermatozoa, the transport of ovum during ovulation and the transport of the fertilized ovum to the intramural fallopian tube." . [] oboInOwl:hasDbXref "ISBN:087694289" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000400 ; owl:annotatedTarget "Obsolete. Use PO:0000332 from Plant Ontology instead. An epidermal cell with a characteristic convoluted anticlinal cell wall that gives a jigsaw like appearance to the lamina." . [] oboInOwl:hasDbXref "PMID:10322630" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030008 ; owl:annotatedTarget "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the pronephros." . [] oboInOwl:hasDbXref "ZFA:0001673" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030008 ; owl:annotatedTarget "pronephric glomerular visceral epithelial cell" . _:genid1778 oboInOwl:hasDbXref "doi:10.1016/B978-0-12-817424-1.00001-X" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000402 ; owl:annotatedTarget "OBSOLETE. An interneuron that has its cell body in a central nervous system." ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_50557 . [] oboInOwl:hasDbXref "PMID:23799132", "PMID:23897681", "PMID:31249312" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030009 ; owl:annotatedTarget "A brush border cell that is part of segment 1 (S1) of the proximal tubule epithelium, located in the renal cortex." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM927.DQNW.448" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4030009 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" . [] oboInOwl:hasDbXref "PMID:23799132", "PMID:23897681", "PMID:31249312", "PMID:31253652" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030010 ; owl:annotatedTarget "A brush border cell that is part of segment 2 (S2) of the proximal tubule epithelium, located in the renal cortex. In addition to its reabsorptive functions, it is also specialized in the secretion of organic anions and cations, including para-aminohippurate." . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000404 ; owl:annotatedTarget "A cell that initiates an electrical signal and passes that signal to another cell." . [] oboInOwl:hasDbXref "PMID:23799132", "PMID:31249312" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030011 ; owl:annotatedTarget "A brush border cell that is part of segment 3 (S3) of the proximal tubule epithelium, which extends from the medullary rays of the renal cortex into the outer medulla." . [] oboInOwl:hasDbXref "PMID:31249312" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030011 ; owl:annotatedTarget "The epithelial cell of proximal tubule segment 3 operates under relatively hypoxic conditions and is particularly susceptible to ischemic injury." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000404 ; owl:annotatedTarget "ZFA:0009193" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:33769951" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030012 ; owl:annotatedTarget "Epithelial cell of the descending thin limb of the short loop (cortical) nephron limited to the outer medulla (mainly inner strip). It is known in some mammalian species that the short descending limb of the loop of Henle selectively expresses the serine protease Corin, the homeobox TF Uncx, and the urea channel Slc14a2." . [] oboInOwl:hasDbXref , "PMID:33769951" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030013 ; owl:annotatedTarget "Epithelial cell of the descending thin limb of the long loop (juxtamedullary) nephron that spans the outer medulla (inner stripe). It is known in some mammalian species that the long descending limb of the loop of Henle in the outer medulla selectively expresses the secreted activin-antagonist protein follistatin (Fst), the GPI-linked adhesion protein Cdh13, and the protein kinase Stk32a." . [] oboInOwl:hasDbXref , "PMID:33769951", "https://www.ncbi.nlm.nih.gov/gene/8170" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030014 ; owl:annotatedTarget "Epithelial cell of the descending thin limb of the long loop (juxtamedullary) nephron that spans the inner medulla. It is known in some mammalian species that the long descending limb of the loop of Henle in the inner medulla selectively expresses the nuclear receptor Nr2e3, the Ig kappa chain Igkc, and the secreted protein dermokine (Dmkn). SLC14A2, which expresses a urea transporter, is also expressed in the inner medulla." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000406 ; owl:annotatedTarget "ZFA:0009194" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:31249312", "PMID:9890303" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030015 ; owl:annotatedTarget "A renal alpha-intercalated cell that is part of the collecting duct of the renal tubule." . [] oboInOwl:hasDbXref "PMID:9890303" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030015 ; owl:annotatedTarget "kidney collecting duct intercalated cell type A" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM483.MXQP.399" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4030015 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-cortical-collecting-duct/v1.3/assets/2d-ftu-kidney-cortical-collecting-duct.png" . [] oboInOwl:hasDbXref , "PMID:24855283" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030016 ; owl:annotatedTarget "An epithelial cell located in the early distal convoluted tubule." . [] oboInOwl:hasDbXref "PMID:24855283" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4030016 ; owl:annotatedTarget "DCT1 cell" . [] oboInOwl:hasDbXref , "PMID:24855283" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030017 ; owl:annotatedTarget "An epithelial cell located in the late distal convoluted tubule." . [] oboInOwl:hasDbXref "PMID:24855283" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4030017 ; owl:annotatedTarget "DCT2 cell" . [] oboInOwl:hasDbXref "PMID:24855283" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030017 ; owl:annotatedTarget "Although mineralocorticoid receptors are expressed throughout the entire [distal convoluted tubule], the DCT2 is sensitive to the actions of aldosterone, because it expresses an enzyme called 11-β hydroxysteroid dehydrogenase 2 (11-βHSD2)" . [] oboInOwl:hasDbXref "doi:10.1016/B978-0-12-408088-1.00002-6", "doi:10.1023/a:1018564904170" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000407 ; owl:annotatedTarget "A cell that anchors the cell body of a scolopidial neuron to the integument." . [] oboInOwl:hasDbXref , "PMID:27582101", "PMID:31249312" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030018 ; owl:annotatedTarget "A renal principal cell located in the connecting tubule." . [] oboInOwl:hasDbXref "PMID:9890303" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030019 ; owl:annotatedTarget "A renal intercalated cell that is part of the renal connecting tubule." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000407 ; owl:annotatedTarget "FBbt:00005221" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:2254448", "PMID:24937428", "PMID:9890303" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030020 ; owl:annotatedTarget "A renal alpha-intercalated cell that is part of the renal connecting tubule." . [] oboInOwl:hasDbXref "PMID:24937428" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030020 ; owl:annotatedTarget "connecting tubule A-IC" . [] oboInOwl:hasDbXref "PMID:9890303" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030020 ; owl:annotatedTarget "kidney connecting tubule intercalated cell type A" . [] oboInOwl:hasDbXref "PMID:2254448", "PMID:9890303" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030021 ; owl:annotatedTarget "A renal beta-intercalated cell that is part of the renal connecting tubule." . [] oboInOwl:hasDbXref "PMID:32065116" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030021 ; owl:annotatedTarget "connecting tubule B-IC" . [] oboInOwl:hasDbXref "PMID:9890303" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030021 ; owl:annotatedTarget "kidney connecting tubule intercalated cell type B" . [] oboInOwl:hasDbXref , "PMID:10559635" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030022 ; owl:annotatedTarget "A fibroblast that is located in the renal medulla interstitium." . [] oboInOwl:hasDbXref "PMID:10559635" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030022 ; owl:annotatedTarget "It has been noted that inner medullary fibroblasts are involved in the regulation of water and electrolyte homeostasis." . [] oboInOwl:hasDbXref , "PMID:30069044", "PMID:32726565", "PMID:33442032" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030023 ; owl:annotatedTarget "A hillock cell that is located in respiratory epithelium. In some mammalian species, this cell type has been noted to express KRT13 and KRT4 and is postulated to play a role in squamous barrier function and immunomodulation." . [] oboInOwl:hasDbXref "PMID:30069044" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030024 ; owl:annotatedTarget "An epithelial, transitional cell type between basal and secretory; located in stratified, non-ciliated structures (called hillocks) with high cell turnover in epithelium. In some mammalian species, this cell type has been noted to express KRT13 and is postulated to play a role in squamous barrier function and immunomodulation." . [] oboInOwl:hasDbXref "PMID:10559635" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030025 ; owl:annotatedTarget "A fibroblast that is located in the renal cortical interstitium." . [] oboInOwl:hasDbXref "PMID:16230044" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030025 ; owl:annotatedTarget "Renal cortical fibroblasts have key roles in mediating intercellular communication with neighboring/infiltrating cells and extracellular matrix and maintenance of renal tissue architecture. They additionally have an endocrine function in the production of epoetin." . [] oboInOwl:hasDbXref , "PMID:24223998", "PMID:35176508" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030026 ; owl:annotatedTarget "An enterocyte of the human intestine expressing bestrophin-4 (BEST4) calcium-activated ion channels." . [] oboInOwl:hasDbXref "https://doi.org/10.1016/j.cell.2020.08.013" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030027 ; owl:annotatedTarget "An amacrine cell that uses GABA as a neurotransmitter." . [] oboInOwl:hasDbXref "https://doi.org/10.1016/j.cell.2020.08.013" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030028 ; owl:annotatedTarget "An amacrine cell that uses glycine as a neurotransmitter." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030029 ; owl:annotatedTarget "A lymphocyte located in blood." . [] oboInOwl:hasDbXref , , "PMID:31092833", "https://sciencing.com/what-peripheral-blood-4672930.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030030 ; owl:annotatedTarget "A blood lymphocyte located in the flowing, circulating blood of the body." . [] oboInOwl:hasDbXref "PMID:17289566", "doi:/10.1038/sj.eye.6700575" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000036 ; owl:annotatedTarget "A somatic stem cell that is committed to an epithelial fate, possessing the capacity for self-renewal and the ability to differentiate into one or more distinct mature cell types of the epithelial lineage. This cell is crucial for the development, homeostasis, repair, and regeneration of epithelial tissues." . [] oboInOwl:hasDbXref "PMID:24987007" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030031 ; owl:annotatedTarget "Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. \"Interstitial cell\" is a morphological term and refers to a variety of cells with differing origins and phenotypes." . [] oboInOwl:hasDbXref , "PMID:25311230", "https://doi.org/10.1098/rsif.2017.0580", "https://doi.org/10.1161/ATVBAHA.120.314789", "https://doi.org/10.1161/JAHA.117.006339", "https://doi.org/10.2353/ajpath.2007.070251" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030032 ; owl:annotatedTarget "An interstitial cell that is part of a cardiac valve leaflet. Along with valve endothelial cells, a valve interstitial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes." . [] oboInOwl:hasDbXref "PMID:25311230", "PMID:30796046" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030032 ; owl:annotatedTarget "VIC" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000408 ; owl:annotatedTarget obo:CL_0000015 . [] oboInOwl:hasDbXref "PMID:25311230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030032 ; owl:annotatedTarget "valvular interstitial cell" . [] oboInOwl:hasDbXref "PMID:25311230" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030032 ; owl:annotatedTarget "Activated valve interstitial cells undergo continual turn over into deactivated fibroblasts and other cell fates (such as apoptosis)." . [] oboInOwl:hasDbXref "PMID:25311230" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030033 ; owl:annotatedTarget "An endothelial cell that lines a surface of a cardiac valve leaflet. Along with valve interstitial cells, a valve endothelial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes." . [] oboInOwl:hasDbXref "PMID:25311230", "PMID:30796046" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030033 ; owl:annotatedTarget "VEC" . [] oboInOwl:hasDbXref "PMID:25311230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030033 ; owl:annotatedTarget "valvular endothelial cell" . [] oboInOwl:hasDbXref "PMID:25311230" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030033 ; owl:annotatedTarget "At least in some mammalian species, a valve endothelial cell expresses CD31. Valve endothelial cells can undergo an endothelial to mesenchymal transition to acquire a fibroblast or myofibroblast phenotype that leads to changes in the microenvironmental signals and facilitates tissue regeneration." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000408 ; owl:annotatedTarget obo:CL_0000300 . [] oboInOwl:hasDbXref "PMID:18757316", "PMID:21364219", "PMID:34044844", "PMID:37834236" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030034 ; owl:annotatedTarget "A multiciliated epithelial cell located in the respiratory tract epithelium, characterized by a columnar shape and motile cilia on its apical surface. This cell develops through a highly orchestrated process, transitioning from a basal progenitor via an intermediate deuterosomal cell stage that generates centrioles essential for ciliogenesis." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000408 ; owl:annotatedTarget "Any male germ cell that has characteristic some haploid and is capable of some fertilization." . [] oboInOwl:hasDbXref , "DOI:10.1177/154405910208100806" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030035 ; owl:annotatedTarget "A dental pulp cell that possesses stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation." . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030035 ; owl:annotatedTarget "DPSC" . _:genid17936 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061535, obo:UBERON_0000079 . [] oboInOwl:hasDbXref "https://www.proteinatlas.org/humanproteome/single+cell+type/Germ+cells#earlyspermatids" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030036 ; owl:annotatedTarget "A spermatid in an early stage of maturation that has a round morphology and is transcriptionally active." . [] oboInOwl:hasDbXref "https://doi.org/10.1016/B978-0-323-01970-5.50014-2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030036 ; owl:annotatedTarget "round spermatid" . [] oboInOwl:hasDbXref "DOI:10.1016/j.semcdb.2016.04.009", "DOI:10.1242/dev.202046", "https://www.ncbi.nlm.nih.gov/books/NBK26843/", "https://www.ncbi.nlm.nih.gov/books/NBK553142/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000408 ; owl:annotatedTarget """The male gamete, also known as a sperm cell, is a highly specialized cell type critical to sexual reproduction. Sperm are produced during a process called spermatogenesis within the male reproductive organ, specifically the testes. They are haploid cells, carrying the genetic material from the male parent, and fuse with the ovum, the female gamete, to form a diploid zygote during fertilization, thereby initiating gestation and the development of a new organism. The male gamete is distinguished by its morphology, notably its elongated shape which is geared towards locomotion. One of the primary characteristics of a male gamete is its flagellum, or tail, which propels the cell towards the female gamete. It additionally contains an elongated head region housing the nucleus, where the genetic material is stored. The anterior section of the head, the acrosome, releases enzymes essential for penetrating the protective layers of the ovum during the fertilization process. The function of male gametes does not cease upon fertilization. In addition to delivering the paternal set of chromosomes, fusion of the sperm cell with the ovum causes an increase in cytosolic Ca2+ which then activates the female egg cell to undergo the so-called cortical reaction during which the egg’s zona pellucida is changed so fusion with additional sperm is prevented. The Ca2+ signal also initiates the development of the zygote and eventual formation of an embryo. Male gametes also contribute towards forming the placenta, which supplies nutrients and removes waste products during gestation. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "https://www.proteinatlas.org/humanproteome/single+cell+type/Germ+cells#latespermatids" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030037 ; owl:annotatedTarget "A spermatid in a late stage of maturation that has an elongated morphology and is transcriptionally inert when the acrosome is fully developed." . [] oboInOwl:hasDbXref "https://doi.org/10.1016/B978-0-323-01970-5.50014-2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030037 ; owl:annotatedTarget "elongated spermatid" . [] oboInOwl:hasDbXref "PMID:21281815", "PMID:23124355" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030038 ; owl:annotatedTarget "A CD24-positive, CD-133-positive, vimentin-positive cell found scattered throughout a renal proximal tubule and that may participate in tubular regeneration. Compared to other proximal tubular cell types, this cell contains less cytoplasm, fewer mitochondria and no brush border." . [] a owl:Axiom ; rdfs:label "male gamete on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000408 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000408" . [] oboInOwl:hasDbXref "https://doi.org/10.1002/stem.1130" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4030038 ; owl:annotatedTarget "CD133+CD24+CD106- tubular cell" . [] oboInOwl:hasDbXref "PMID:23124355" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4030038 ; owl:annotatedTarget "CD24+CD133+ tubular cell" . [] oboInOwl:hasDbXref "PMID:23124355" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4030038 ; owl:annotatedTarget "CD24-positive tubular cell" . [] oboInOwl:hasDbXref "PMID:23124355" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030038 ; owl:annotatedTarget "After acute tubular injury, this cell type becomes more numerous. In healthy rat kidneys, this cell is not detectable, whereas after unilateral ureteral obstruction (renal injury), it may appear de novo, arguing against the notion that this cell type represents a pre-existing progenitor cell population. In at least one study, data indicate that this cell type represents transiently dedifferentiated tubular cells involved in regeneration." . [] oboInOwl:hasDbXref "DOI:10.1007/BF02970950", "DOI:10.1101/2022.10.12.511898", "PMID:32127543" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030039 ; owl:annotatedTarget "An extratelencephalic-projecting glutamatergic cortical neuron that is morphologically-defined with a large, spindle-shaped cell body, thick bipolar dendrites with limited branching and a moderate density of spines, and often an axon initial segment that emanates from the side of the cell body. This cell type is associated with markers POU3F, BMP3 and ITGA4." . [] oboInOwl:hasDbXref "PMID:32127543" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030039 ; owl:annotatedTarget "VEN" . [] oboInOwl:hasDbXref "PMID:32127543" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030039 ; owl:annotatedTarget "In humans, a von Economo neuron is restricted to layer 5 of the anterior cingulate, frontoinsular, and medial frontopolar regions of cerebral cortex, while in some other species it is also found in the frontal and occipital poles and may not be restricted to layer 5." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000410 ; owl:annotatedTarget "ZFA:0009195" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:31290979", "PMID:37999981", "doi:10.1016/j.coemr.2024.100503", "doi:10.1038/s41591-020-1040-z", "https://www.proteinatlas.org/humanproteome/single+cell+type/Glandular+epithelial+cells#endometrialciliatedcells" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030040 ; owl:annotatedTarget "A multi-ciliated cell of the endometrial epithelium. This cell is characterized by the presence of 9+2 motile cilia on its apical surface, which facilitates the movement of mucus across the endometrial surface." . [] oboInOwl:hasDbXref "ttps://www.nature.com/articles/s41591-020-1040-z" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030040 ; owl:annotatedTarget "In human samples, the expression of FOXJ1 protein, a regulator for motile cilia with epithelial lineage identity, has been noted." . [] oboInOwl:hasDbXref "doi:10.1038/s41591-020-1040-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030041 ; owl:annotatedTarget "A ciliated cell of the endometrial luminal epithelium. This cell is characterized by the presence of motile cilia on its apical surface." . [] oboInOwl:hasDbXref "doi:10.1038/s41591-020-1040-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030042 ; owl:annotatedTarget "A ciliated cell of the endometrial glandular epithelium. This cell is characterized by the presence of motile cilia on its apical surface." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030043 ; owl:annotatedTarget "A DRD1-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030043 ; owl:annotatedTarget "D1-matrix" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030043 ; owl:annotatedTarget "D1M" . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.wormatlas.org/hermaphrodite/hypodermis/mainframe.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000411 ; owl:annotatedTarget "An epithelial cell of the hypodermis of Caenorhabditis." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030043 ; owl:annotatedTarget "matrix D1-MSN" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030043 ; owl:annotatedTarget "In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030047 ; owl:annotatedTarget "A DRD2-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030047 ; owl:annotatedTarget "D2-matrix" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030047 ; owl:annotatedTarget "D2M" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000411 ; owl:annotatedTarget "ZFA:0009196" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030047 ; owl:annotatedTarget "matrix D2-MSN" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030047 ; owl:annotatedTarget "In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030048 ; owl:annotatedTarget "A DRD1-expressing medium spiny neuron that is part of a striosome of dorsal striatum." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030048 ; owl:annotatedTarget "striosome D1 medium spiny neuron" . [] oboInOwl:hasDbXref "DOI:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030048 ; owl:annotatedTarget "D1-striosome" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030048 ; owl:annotatedTarget "D1S" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030048 ; owl:annotatedTarget "striosome D1-MSN" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030048 ; owl:annotatedTarget "In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030049 ; owl:annotatedTarget "A DRD2-expressing medium spiny neuron that is part of a striosome of dorsal striatum." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030049 ; owl:annotatedTarget "striosome D2 medium spiny neuron" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030049 ; owl:annotatedTarget "D2-striosome" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030049 ; owl:annotatedTarget "D2S" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030049 ; owl:annotatedTarget "striosome D2-MSN" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030049 ; owl:annotatedTarget "In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030050 ; owl:annotatedTarget "A medium spiny neuron that expresses both DRD1 and DRD2 and is part of an extra-striosomal part of dorsal striatum." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030050 ; owl:annotatedTarget "D1/2" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030050 ; owl:annotatedTarget "D1/D2 hybrid" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030050 ; owl:annotatedTarget "D1/D2-hybrid MSN" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030050 ; owl:annotatedTarget "hybrid D1/2 cell type" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030050 ; owl:annotatedTarget "It has been noted in non-human primate species that the D1/D2-hybrid medium spiny neuron (D1/2) cell type shows the same amount of DRD1 expression as nearby D1 medium spiny neurons but far less DRD2 expression compared to nearby D2 medium spiny neurons. In Rhesus macaques, RXFP1 has been noted as a highly specific marker gene for the D1/2 cell type. The D1/2 cell type has also been described as having characteristics similar to a novel medium spiny neuron described in rodents (D1H or eccentric spiny projection neuron). Although an extrastriosomal cell type, the D1/2 cell type had been noted to express many of the genes associated with striosome, suggesting a possible homology to ‘‘exo-patch’’ cells." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030051 ; owl:annotatedTarget "A DRD1-expressing medium spiny neuron that is part of a nucleus accumbens shell or olfactory tubercle." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030051 ; owl:annotatedTarget "NAc shell and OT D1 medium spiny neuron" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030051 ; owl:annotatedTarget "D1Sh" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030051 ; owl:annotatedTarget "NAc shell and OT D1-MSN" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030051 ; owl:annotatedTarget "In Rhesus macaques, both nucleus accumbens shell and olfactory tubercle D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: GREB1L, ARHGAP6, and GRIA4." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030052 ; owl:annotatedTarget "A DRD2-expressing medium spiny neuron that is part of a nucleus accumbens shell or olfactory tubercle." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030052 ; owl:annotatedTarget "NAc shell and OT D2 medium spiny neuron" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030052 ; owl:annotatedTarget "D2Sh" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030052 ; owl:annotatedTarget "NAc shell and OT D2-MSN" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030052 ; owl:annotatedTarget "nucleus accumbens shell and olfactory tubercle D2-MSN" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030052 ; owl:annotatedTarget "In Rhesus macaques, both nucleus accumbens shell and olfactory tubercle D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: GREB1L, ARHGAP6, and GRIA4." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030053 ; owl:annotatedTarget "A DRD1-expressing, medium spiny neuron-like granule cell that is part of an Island of Calleja." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030053 ; owl:annotatedTarget "D1-ICj" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030053 ; owl:annotatedTarget "In Rhesus macaques, the Island of Calleja granule cell type has been noted to have enriched gene expression of CPNE4." . [] oboInOwl:hasDbXref "FB:ma", "PMID:32646579", "https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/07%3A_Cell_Division/7.04%3A_Polyploidy"^^xsd:anyURI ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000412 ; owl:annotatedTarget "A cell that contains more than two haploid sets of chromosomes." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030054 ; owl:annotatedTarget "A DRD1-expressing medium spiny neuron that is part of dense, RXFP1-positive cell islands throughout the nucleus accumbens, putamen, and near the adjacent septal nuclei." . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030054 ; owl:annotatedTarget "RXFP1-positive island D1-medium spiny neuron" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030054 ; owl:annotatedTarget "D1-NUDAP" . [] oboInOwl:hasDbXref "doi:10.1016/j.cub.2021.10.015" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030054 ; owl:annotatedTarget "Regarding the abbreviation D1-NUDAP, NUDAP stands for \"neurochemically unique domains in the accumbens and putamen\". In Rhesus macaques, the RXFP1-positive interface island D1-medium spiny neuron (D1-NUDAP) has been noted to have upregulation of OPRM1 compared to DRD1-expressing medium spiny neurons located outside of the D1-exclusive island and in Islands of Calleja. Kappa-opioid receptor gene (OPRK1) has been noted to be absent from D1-NUDAP cells. Many striosome-specific markers have been noted to be upregulated in D1-NUDAP cells, including KCNIP1, KCNT1, KHDRBS3, and BACH2. PDYN, an acknowledged D1-striosome marker gene, has also been noted to be expressed in D1-NUDAPs. D1-NUDAPs also express some genes found to be selectively expressed in the matrix, including STXBP6, GDA, and SEMA3E. Gene enrichment analysis has revealed that D1-NUDAP neurons express genes that have been implicated in drug addiction and many other functions." . [] oboInOwl:hasDbXref "doi:10.1038/s41385-022-00565-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030055 ; owl:annotatedTarget "A urothelial cell that is part of the regenerative layer(s) of cells directly superficial to basal cells in urothelium. The layer of intermediate cells in the urothelium ranges from one to several layers thick depending on the species with intermediate cells attached to adjacent cell layers and one another via desmosomes." . [] oboInOwl:hasDbXref "doi:10.1007/978-3-030-14366-4_8" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030055 ; owl:annotatedTarget "urothelial intermediate cell" . [] oboInOwl:hasDbXref "doi:10.1038/s41385-022-00565-0" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030055 ; owl:annotatedTarget "It has been noted in at least some mammalian species that the urothelial intermediate cell type is similar to basal cells by expressing CK17 and (unlike umbrella cells) p63 but is positive for uroplakins (UPK) and negative for CK5. Urothelial intermediate cells have also been noted to be larger in diameter than urothelial basal cells." . [] oboInOwl:hasDbXref "doi:10.1038/s41385-022-00565-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030056 ; owl:annotatedTarget "A urothelial cell that is terminally differentiated and part of the urothelial apical surface that forms the high-resistance barrier of urothelium. Umbrella cells have been described as the largest of urothelial cell types, highly polarized, and, in some species, multinucleated. In the relaxed state, these cells form a dome-shaped structure at the apical pole and can also cover multiple underlying intermediate cells, leading to the name umbrella cells. In contrast, these cells flatten when the bladder is filled." . [] oboInOwl:hasDbXref "doi:10.1038/s41385-022-00565-0" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030056 ; owl:annotatedTarget "facet cell of urothelium" . [] oboInOwl:hasDbXref "doi:10.1038/s41385-022-00565-0" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030056 ; owl:annotatedTarget "superficial cell of urothelium" . [] oboInOwl:hasDbXref "doi:10.1038/s41385-022-00565-0" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030056 ; owl:annotatedTarget "Umbrella cells are attached to sub-superficial cell layers via desmosomes, while tight junctions localized between superficial cells aid in forming a high-resistance barrier function. Another distinguishing feature of an umbrella cell type is the presence of subapical discoidal/fusiform-shaped vesicles contributing to the plasticity in urothelial cell surface area through a regulated process of endocytosis/exocytosis. It has been noted in at least some mammalian species that the urothelial umbrella cell type expresses UPK1A, UPK1B, UPK2 and UPK3A. Unlike intermediate and basal cells of the urothelium, CK17 is reported to be completely absent and p63 not expressed in umbrella cells." . [] oboInOwl:hasDbXref "doi:10.1016/j.cell.2018.07.028", "doi:10.1101/2022.10.12.511898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030057 ; owl:annotatedTarget "A medium spiny neuron that exhibits transcriptional divergence from direct and indirect spiny projection neurons, for example, enrichment in Casz1, Otof, Cacng5 and Pcdh8 noted in mice. Whilst in general medium spiny neurons have been found to be differentially distributed across the basal ganglia, the eccentric medium spiny neuron cell type has been found to be more evenly distributed throughout cerebral nuclei." . [] oboInOwl:hasDbXref "doi:10.1016/j.cell.2018.07.028" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030057 ; owl:annotatedTarget "eccentric spiny projection neuron" . [] oboInOwl:hasDbXref "doi:10.1016/j.cell.2018.07.028" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030057 ; owl:annotatedTarget "eSPN" . [] oboInOwl:hasDbXref "doi:10.1101/2022.10.12.511898" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030057 ; owl:annotatedTarget "eccentric MSN" . [] oboInOwl:hasDbXref "doi:10.1016/j.cell.2018.07.028" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030057 ; owl:annotatedTarget "eccentric SPN" . [] oboInOwl:hasDbXref "doi:10.1016/j.cell.2018.07.028", "doi:10.1101/2022.10.12.511898" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030057 ; owl:annotatedTarget "The term “eccentric” is used in the name eccentric medium spiny neuron (MSN) due to the exhibited transcriptional divergence from canonical spiny projection neurons. It has been noted in at least one study that an eccentric MSN differs in expression from direct and indirect MSNs by 110 genes (more than the 68 that distinguished direct and indirect spiny projection neurons from each other) and expresses many genes that have little expression in the rest of the striatum. It also has been noted in at least one human study that most eccentric MSNs expressed only DRD1, but many in the basal ganglia co-expressed DRD1 and DRD2, suggesting regional specialization of a more broadly distributed cell type." . [] oboInOwl:hasDbXref , "PMID:26074923" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030058 ; owl:annotatedTarget "A macrophage that expresses the T cell receptor complex at the cell surface." . [] oboInOwl:hasDbXref "PMID:26074923" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030058 ; owl:annotatedTarget "T cell receptor positive macrophage" . [] oboInOwl:hasDbXref "PMID:26074923" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030058 ; owl:annotatedTarget "TCR+ macrophage" . [] oboInOwl:SynonymTypeProperty obo:OMO_0003000 ; oboInOwl:hasDbXref "PMID:37500727" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030058 ; owl:annotatedTarget "TCR.macs" . [] oboInOwl:hasDbXref "PMID:25622573", "PMID:34004146", "PMID:37292694", "PMID:37824655", "https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030059 ; owl:annotatedTarget "A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found between cortical layer 2-4. This intratelencephalic-projecting glutamatergic neuron has thin-tufted apical dendrites and extends its axonal projection into L5 in the neocortex. This neuronal type has a hyperpolarised resting membrane potential. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', clusters L2/3 IT." . [] oboInOwl:hasDbXref "PMID:34004146" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030059 ; owl:annotatedTarget "L2/3 IT" . [] oboInOwl:hasDbXref "PMID:37824655" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030059 ; owl:annotatedTarget "Hystorically, the L2/3 intratelencephalic projectic glutametergic neuron was known to have its soma in cortical layer 2/3. MERFISH data showed that this intratelencephalic-projecting glutametergic neuron can have its soma in layer 2/3, 4B, 4C. The position of the soma in layer 4b and 4C is less frequent for this neuronal type in comparison to cortical layer 2/3." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030059 ; owl:annotatedTarget "The marker set ONECUT2, COL5A2 can identify the Human cell type L2/3 intratelencephalic projecting glutamatergic neuron in the neocortex with a confidence of 0.670149932 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "PMID:34004146" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030060 ; owl:annotatedTarget "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2." . [] oboInOwl:hasDbXref "PMID:34004146" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030060 ; owl:annotatedTarget "L2 IT" . [] oboInOwl:hasDbXref "PMID:34004146" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030061 ; owl:annotatedTarget "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3." . [] oboInOwl:hasDbXref "PMID:34004146" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030061 ; owl:annotatedTarget "L3 IT" . [] oboInOwl:hasDbXref "PMID:34004146" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030062 ; owl:annotatedTarget "An intratelencephalic-projecting glutamatergic with a soma located in cortical layer 4/5." . [] oboInOwl:hasDbXref "PMID:34004146" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030062 ; owl:annotatedTarget "L4/5 IT" . [] oboInOwl:hasDbXref "FB:ma", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000413 ; owl:annotatedTarget "A cell whose nucleus contains a single haploid genome." . [] oboInOwl:hasDbXref "PMID:37292694", "PMID:37824655", "https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030063 ; owl:annotatedTarget "A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3-4. This neuron type can have a pyramidal, star-pyramidal or spiny stellate morphology and projects its output to L2/3 and L5A/B. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L4 IT." . [] oboInOwl:hasDbXref "PMID:37292694" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030063 ; owl:annotatedTarget "L4 IT" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030063 ; owl:annotatedTarget "The marker set RORB, ST8SIA4 can identify the Human cell type L4 intratelencephalic projecting glutamatergic neuron in the neocortex with a confidence of 0.720108696 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "FB:ma", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000414 ; owl:annotatedTarget "OBSOLETE: A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei." . [] oboInOwl:hasDbXref "PMID:37292694", "PMID:37609206", "PMID:37824655", "https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030064 ; owl:annotatedTarget "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 5. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L5 IT." . [] oboInOwl:SynonymTypeProperty obo:OMO_0003000 ; oboInOwl:hasDbXref "PMID:37292694" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030064 ; owl:annotatedTarget "L5 IT" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030064 ; owl:annotatedTarget "The marker set ARSJ, RORB, KCNK2 can identify the Human cell type L5 intratelencephalic projecting glutamatergic neuron in the neocortex with a confidence of 0.764261336 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000415 ; owl:annotatedTarget "A cell whose nucleus has two haploid genomes." . [] oboInOwl:hasDbXref "PMID:37292694", "PMID:37609206", "PMID:37824655", "https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030065 ; owl:annotatedTarget "A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L6 IT." . [] oboInOwl:hasDbXref "PMID:37292694" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030065 ; owl:annotatedTarget "L6 IT" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030065 ; owl:annotatedTarget "The marker set LINC00507, THEMIS can identify the Human cell type L6 intratelencephalic projecting glutamatergic neuron in the neocortex with a confidence of 0.641695703 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "PMID:9374839" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_4030066 ; owl:annotatedTarget _:genid15717 . [] oboInOwl:hasDbXref "PMID:17133361", "PMID:24183650", "PMID:9374839" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030066 ; owl:annotatedTarget "An epithelial cell that is part of a ureteric bud. A ureteric bud cell has the potential to induce metanephric mesenchymal cells to proliferate and convert to epithelia that form renal tubules via: (1) the secretion of multiple diffusible growth factors that rescue renal progenitors from apoptosis and stimulate them to proliferate and (2) contact-dependent mechanisms that induce mesenchymal-epithelial conversion." . [] oboInOwl:hasDbXref "PMID:24183650" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030066 ; owl:annotatedTarget "UB cell" . [] oboInOwl:hasDbXref "PMID:34004146", "PMID:37292694", "PMID:37824655" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030067 ; owl:annotatedTarget "A near-projecting glutamatergic neuron with a soma found in cortical layer 5/6." . [] oboInOwl:hasDbXref "PMID:34004146" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030067 ; owl:annotatedTarget "L5/6 NP" . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.wormatlas.org/ver1/handbook/hypodermis/hypsupportother.htm#arcadecells" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000418 ; owl:annotatedTarget "An epithelial cell found in C. elegans that firmly hold the outer body wall and the lips to the inner cylinder of the pharynx in a manner that keeps these organs from breaking apart, while still giving each organ freedom of movement during feeding." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030067 ; owl:annotatedTarget "The marker set NPSR1-AS1, TLL1 can identify the Human cell type L5/6 near-projecting glutamatergic neuron in the neocortex with a confidence of 0.899288218 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "PMID:34004146", "PMID:37824655", "doi:10.1007/s00424-024-02923-2", "doi:10.1101/2022.11.30.518285" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030068 ; owl:annotatedTarget "A transcriptomically distinct intratelencepalic-projecting glutamatergic neuron that expresses Car3 with a soma found in L6 . The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_cluster', L6 IT Car3." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.wormatlas.org/hermaphrodite/seam%20cells/mainframe.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000419 ; owl:annotatedTarget "An epithelial fate stem cell found in flatworms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030068 ; owl:annotatedTarget "L6 IT Car3 glutamatergic neuron" . [] oboInOwl:hasDbXref "doi:10.1101/2022.11.06.515349" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030068 ; owl:annotatedTarget "L6 IT Car3" . [] oboInOwl:hasDbXref "PMID:37824655" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030068 ; owl:annotatedTarget "L6 IT Car3 neuron" . [] oboInOwl:hasDbXref "doi:10.1101/2022.11.30.518285" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030068 ; owl:annotatedTarget "L6-IT-Car3" . [] oboInOwl:hasDbXref "PMID:37824655" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4030068 ; owl:annotatedTarget "L6-IT-Car3 cell" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030068 ; owl:annotatedTarget "The marker set SMYD1, THEMIS can identify the Human cell type L6 intratelencephalic projecting Car3 glutamatergic neuron in the neocortex with a confidence of 0.877752028 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "PMID:30566875", "PMID:32497356" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4032000 ; owl:annotatedTarget "An epithelial cell of the urethra that has an expression profile similar to lung club cells. Club-like cells of the urethra epithelium are similar to lung club cells in their expression of SCGB1A1 and in their enrichment of immunomodulatory programs." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-7258-9596" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4032000 ; owl:annotatedTarget "club-like cell of the prostatic urethra epithelium" . [] oboInOwl:hasDbXref "PMID:30566875" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4032000 ; owl:annotatedTarget "prostate club cell" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000421 ; owl:annotatedTarget "A free floating cell, including amebocytes and eleocytes, in the coelom of certain animals, especially annelids." . [] oboInOwl:hasDbXref "PMID:30566875" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4032000 ; owl:annotatedTarget "Club cells typically refer to bronchiolar exocrine cells found in the lungs. This cell type is given the name club cell due to their similarity to club cells in the lungs." . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000422 ; owl:annotatedTarget "A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment." . [] oboInOwl:hasDbXref "PMID:23803971" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4032001 ; owl:annotatedTarget "A GABAergic interneuron located in the cerebral cortex that expresses reelin (rln)." . [] oboInOwl:hasDbXref "PMID:29904965" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4032001 ; owl:annotatedTarget "rln GABAergic cortical interneuron" . [] oboInOwl:hasDbXref "PMID:28217126" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033000 ; owl:annotatedTarget "A(n) endothelial cell that is part of a(n) venule of lymph node." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19783135" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000424 ; owl:annotatedTarget "A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids." . [] oboInOwl:hasDbXref "PMID:28217126" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033001 ; owl:annotatedTarget "A(n) endothelial cell that is part of a(n) arteriole of lymph node." . ( ) . [] oboInOwl:hasDbXref "PMID:31390635" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033002 ; owl:annotatedTarget "A(n) neuroendocrine cell that is part of a(n) epithelium of crypt of Lieberkuhn." . [] oboInOwl:hasDbXref "JB:jb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000425 ; owl:annotatedTarget "Forms the terminal part of the cuticle-lined excretory duct of C. elegans." . [] oboInOwl:hasDbXref "PMID:19996346", "PMID:5487122" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033003 ; owl:annotatedTarget "A(n) myoepithelial cell that is part of a(n) bronchus submucosal gland." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM656.TJVD.294" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4033003 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" . [] oboInOwl:hasDbXref "GOC:tfm", "http://wormatlas.psc.edu/hermaphrodite/muscleGLR/mainframe.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000427 ; owl:annotatedTarget "A scaffolding cell type found in C. elegans, this cell plays a supportive role to the muscle arms. May also have an endocrine role." . [] oboInOwl:hasDbXref "PMID:10715339", "PMID:22320805" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033004 ; owl:annotatedTarget "A(n) smooth muscle cell that is part of a(n) taenia coli." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000428 ; owl:annotatedTarget "ZFA:0000084" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:5487122", "PMID:9651178" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033005 ; owl:annotatedTarget "A(n) serous secreting cell that is part of a(n) bronchus submucosal gland." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033005 ; owl:annotatedTarget "The marker set PRR4, C6orf58 can identify the Human cell type serous secreting cell of bronchus submucosal gland in the lung with a confidence of 0.75 (NS-Forest FBeta value)." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM656.TJVD.294" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4033005 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" . [] oboInOwl:hasDbXref "PMID:32094869" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033006 ; owl:annotatedTarget "A(n) endothelial cell that is part of a(n) efferent lymphatic vessel." . [] oboInOwl:hasDbXref "PMID:15817800" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033007 ; owl:annotatedTarget "A(n) brush cell that is part of a(n) epithelium of lobar bronchus." . [] oboInOwl:hasDbXref "doi:10.1007/s00412-016-0595-4" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000429 ; owl:annotatedTarget "A columnar epithelial cell that is part of an insect imaginal disc." . [] oboInOwl:hasDbXref "PMID:34030460" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033008 ; owl:annotatedTarget "A(n) vein endothelial cell that is part of a(n) respiratory system." . [] oboInOwl:hasDbXref "PMID:18757316" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033009 ; owl:annotatedTarget "A(n) goblet cell that is part of a(n) epithelium of lobar bronchus." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000429 ; owl:annotatedTarget "FBbt:00007108" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:26711336", "PMID:33355253" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033010 ; owl:annotatedTarget "A(n) neuroendocrine cell that is part of a(n) epithelium of lobar bronchus." . [] oboInOwl:hasDbXref "PMID:24997029" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033011 ; owl:annotatedTarget "A(n) smooth muscle cell that is part of a(n) large intestine smooth muscle circular layer." . [] oboInOwl:hasDbXref "PMID:24997029" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033012 ; owl:annotatedTarget "A(n) smooth muscle cell that is part of a(n) large intestine smooth muscle longitudinal layer." . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000430 ; owl:annotatedTarget "A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red." . [] oboInOwl:hasDbXref "PMID:35883599", "PMID:9520465", "https://www.proteinatlas.org/humanproteome/single+cell+type/squamous+epithelial+cells#suprabasalkeratinocytes" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033013 ; owl:annotatedTarget "A keratinocyte of the epidermis suprabasal layer. This cell may express the differentiation markers keratin 10 and keratin 1." . [] oboInOwl:hasDbXref "PMID:2210508", "PMID:22911892", "PMID:30023181" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033014 ; owl:annotatedTarget "A small, narrow, peg-shaped epithelial cell with little cytoplasm that is part of oviduct epithelium. This cell is rarer than the ciliated and secretory epithelial cells of the fallopian tube epithelium and is often found intercalated between them. Peg cells are generally distributed basally along the epithelium and have been found in high concentrations at the fimbriated, distal end of the fallopian tube in humans. It may have a regenerative/stem-cell function. In humans, markers include EPCAM, CD44, and ITGA6." . [] oboInOwl:hasDbXref "PMID:22911892" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033014 ; owl:annotatedTarget "FTE stem-like cell" . [] oboInOwl:hasDbXref "PMID:22911892" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033014 ; owl:annotatedTarget "FTESC" . [] oboInOwl:hasDbXref "PMID:22911892" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033014 ; owl:annotatedTarget "fallopian tube epithelial stem-like cell" . [] oboInOwl:hasDbXref "PMID:22911892" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033014 ; owl:annotatedTarget "intercalary cell" . [] oboInOwl:hasDbXref "PMID:22911892" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033014 ; owl:annotatedTarget "In vitro evidence supports a stem-cell/regenerative function for these cells" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000430 ; owl:annotatedTarget "ZFA:0009198" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:25236977", "PMID:33796062" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033015 ; owl:annotatedTarget "A star-shaped glial cell that is part of some retina. This cell links neurons to blood vessels and may provide structural and physiological support to optic nerve head axons." . [] oboInOwl:hasDbXref "PMID:33796062" ; oboInOwl:hasSynonymType obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033015 ; owl:annotatedTarget "retinal astroglia" . [] oboInOwl:hasDbXref "PMID:32555229", "PMID:33796062" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033015 ; owl:annotatedTarget "In response to elevated intraocular pressure, a retinal astrocyte may modulate extracellular matrix remodeling. In the human retina, a retinal astrocyte is GFAP-positive, SOD3-positive and GYPC-positive." . [] oboInOwl:hasDbXref "PMID:31331942", "PMID:33624948" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033016 ; owl:annotatedTarget "A myofibroblast that is part of an alveoli during alveolarization. The contractile force of this cell elongates the secondary crest, while producing a framework of elastin and tenascin. During the maturation of the septa, secondary crest myofibroblasts, together with matrix fibroblasts, secrete metalloproteinases and other ECM‐remodeling proteins to thin the septal tip ECM. The secondary crest myofibroblast continues producing elastin, eventually undergoing apoptosis during adulthood." . [] oboInOwl:hasDbXref "PMID:31331942" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033016 ; owl:annotatedTarget "secondary-crest myofibroblast" . [] oboInOwl:hasDbXref "PMID:33624948" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033016 ; owl:annotatedTarget "SCMF" . [] oboInOwl:hasDbXref "PMID:25448080" ; oboInOwl:hasSynonymType obo:OMO_0003000, obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033016 ; owl:annotatedTarget "SCMFs" . [] oboInOwl:hasDbXref "PMID:31331942" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033016 ; owl:annotatedTarget "alveolar myofibroblast" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM558.BZLS.992" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4033016 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000431 ; owl:annotatedTarget "A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platelets or iridisomes. The color-generating components produce a silver, gold, or iridescent color." . [] oboInOwl:hasDbXref "ISBN:9781260462982", "PMID:15347627" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033017 ; owl:annotatedTarget "A smooth muscle cell that is part of a bronchiole." . [] oboInOwl:hasDbXref "PMID:33351116" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033018 ; owl:annotatedTarget "A megakaryocyte that is resident in the lung connective tissue." . [] oboInOwl:hasDbXref "PMID:36524131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033018 ; owl:annotatedTarget "lung resident megakaryocyte" . [] oboInOwl:hasDbXref "PMID:36524131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033018 ; owl:annotatedTarget "lung-resident megakaryocyte" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000431 ; owl:annotatedTarget "ZFA:0009199" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:36524131" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033018 ; owl:annotatedTarget "MKL" . [] oboInOwl:hasDbXref "PMID:33351116" ; oboInOwl:hasSynonymType obo:OMO_0003000, obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033018 ; owl:annotatedTarget "lung MKs" . [] oboInOwl:hasDbXref "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033019 ; owl:annotatedTarget "An ON bipolar cell type with dendrites selectively contacting S-cones." . [] oboInOwl:hasDbXref "PMID:32032773" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033019 ; owl:annotatedTarget "BB cell" . [] oboInOwl:hasDbXref "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033019 ; owl:annotatedTarget "The axons of a blue cone bipolar cell terminate close to the ganglion cell layer, where they transfer the S-cone ON signal to small bistratified ganglion cells. Other targets of a blue cone bipolar cell include amacrine cells and possibly large bistratified ganglion cells." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "http://en.wikipedia.org/wiki/Reticular_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000432 ; owl:annotatedTarget "A fibroblast that synthesizes collagen and uses it to produce reticular fibers, thus providing structural support. Reticular cells are found in many organs, including the spleen, lymph nodes and kidneys. Subtypes of reticular cells include epithelial, mesenchymal, and fibroblastic reticular cells. Fibroblastic reticular cells are involved in directing B cells and T cells to specific regions within a tissue, whereas epithelial and mesenchymal reticular cells are associated with certain areas of the brain." . [] oboInOwl:hasDbXref "PMID:18931053", "PMID:29656943" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033020 ; owl:annotatedTarget "A mucus secreting cell that is part of a submucosal gland of the trachea." . [] oboInOwl:hasDbXref "PMID:18931053" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033020 ; owl:annotatedTarget "tracheal submucosal gland mucous cell" . [] oboInOwl:hasDbXref "PMID:29656943" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033021 ; owl:annotatedTarget "A myoepithelial cell that is part of a submucosal gland of the trachea." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000432 ; owl:annotatedTarget "ZFA:0009200" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:19965983" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033022 ; owl:annotatedTarget "A mucus secreting cell of a submucosal gland of the bronchus." . [] oboInOwl:hasDbXref "PMID:5487122" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033022 ; owl:annotatedTarget "bronchial gland mucous cell" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033022 ; owl:annotatedTarget "The marker set BPIFB2 can identify the Human cell type mucus secreting cell of bronchus submucosal gland in the lung with a confidence of 0.93 (NS-Forest FBeta value)." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM656.TJVD.294" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4033022 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" . [] oboInOwl:hasDbXref "TAIR:lr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000433 ; owl:annotatedTarget "Obsolete. Use PO:0000244 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that will undergo megagametogenesis." . [] oboInOwl:hasDbXref "PMID:25648514", "PMID:29656943" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033023 ; owl:annotatedTarget "An epithelial cell that is part of a collecting duct of an airway submucosal gland." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033023 ; owl:annotatedTarget "The marker set GLYATL2, DMBT1 can identify the Human cell type airway submucosal gland collecting duct epithelial cell in the lung with a confidence of 0.46 (NS-Forest FBeta value)." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM656.TJVD.294" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4033023 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" . [] oboInOwl:hasDbXref "PMID:29656943", "PMID:35046051" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033024 ; owl:annotatedTarget "A basal cell that is part of a duct of an airway submucosal gland." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM656.TJVD.294" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4033024 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000434 ; owl:annotatedTarget "A secretory cell that discharges its product without loss of cytoplasm." . [] oboInOwl:hasDbXref "wikipedia:Perichondrium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033025 ; owl:annotatedTarget "A fibroblast that is part of the fibrous layer of the perichondrium. This cell is responsible for collagen fiber production." . [] oboInOwl:hasDbXref "PMID:36543915" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033026 ; owl:annotatedTarget "A perichondrial fibroblast that is part of the lung." . [] oboInOwl:hasDbXref "PMID:36543915" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033026 ; owl:annotatedTarget "PC-fibro" . [] oboInOwl:hasDbXref "PMID:22006647" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033027 ; owl:annotatedTarget "An OFF diffuse bipolar cell that makes synaptic contact with both L/M and S-cone photoreceptors and only minimal contact with rod photoreceptors." . [] oboInOwl:hasDbXref "PMID:22006647" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033027 ; owl:annotatedTarget "Diffuse Bipolar Cell Type DB1" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000435 ; owl:annotatedTarget "ZFA:0009201" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:22006647" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033027 ; owl:annotatedTarget "DB1 bipolar" . [] oboInOwl:hasDbXref "PMID:22006647" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033027 ; owl:annotatedTarget "DB1 bipolar cell" . [] oboInOwl:hasDbXref "PMID:32032773" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033027 ; owl:annotatedTarget "DB1 cell" . [] oboInOwl:hasDbXref "PMID:22006647", "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033027 ; owl:annotatedTarget "In primates, a diffuse bipolar 1 cell on average makes 81 ribbon (output) synapses, 13 contacts are with OFF parasol cells and 47 contacts are with OFF midget cells. This cell might make flat contacts at both triad-associated and non-triad-associated positions on the cone pedicle." . [] oboInOwl:hasDbXref "PMID:25309346", "PMID:26500507", "PMID:27833534" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033028 ; owl:annotatedTarget "An OFF diffuse bipolar cell that predominantly connects to ON parasol cells and lateral amacrine cells. This cell contains a large number of synaptic ribbons and a small axon arbor area." . [] oboInOwl:hasDbXref "PMID:32032773" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033028 ; owl:annotatedTarget "DB2 cell" . [] oboInOwl:hasDbXref "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033028 ; owl:annotatedTarget "In primates, a diffuse bipolar 2 cell makes an average of 133 ribbon synapses, 47 contacts are with OFF parasol cells and 4 contacts are with OFF midget cells." . [] oboInOwl:hasDbXref "PMID:32032773", "PMID:32555229", "PMID:33009001" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033029 ; owl:annotatedTarget "An OFF calbindin-positive bipolar cell that has a large dendritic field and stratifies narrowly close to the middle of the inner plexiform layer. Its axon terminal is characterized by regularly branching and varicose processes resembling beads on a string. Most of DB3a contacts with cones are triad-associated." . [] oboInOwl:hasDbXref "DOI:10.3389/fnana.2015.00122" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033029 ; owl:annotatedTarget "DB3 cell" . [] oboInOwl:hasDbXref "PMID:32032773" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033029 ; owl:annotatedTarget "DB3a cell" . [] oboInOwl:hasDbXref "DOI:10.3389/fnana.2015.00122", "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033029 ; owl:annotatedTarget "Originally, DB3a cells were termed diffuse bipolar 3 (DB3) cells. When an additional bipolar type which stratifies slightly more vitread and is calbindin negative was detected, this cell was renamed diffuse bipolar 3a cell. The axons of neighboring DB3a cells make homologous gap junctions. The DB3a cells provide the majority of their output to OFF parasol cells." . [] oboInOwl:hasDbXref "PMID:32032773", "PMID:32555229" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033030 ; owl:annotatedTarget "An OFF calbindin-negative bipolar cell that has a large dendritic field and stratifies narrowly close to the middle of the inner plexiform layer. Its axon terminal is characterized by regularly branching and varicose processes resembling beads on a string. Most of DB3b contacts with cones are non-triad-associated." . [] oboInOwl:hasDbXref "PMID:32032773" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033030 ; owl:annotatedTarget "DB3b cell" . [] oboInOwl:hasDbXref "PMID:24107939", "PMID:32032773", "PMID:33009001" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033030 ; owl:annotatedTarget "In humans, a DB3b cell is CD15 positive. A DB3b cell might make sparse contacts to rod photoreceptors." . [] oboInOwl:hasDbXref "PMID:27833534", "PMID:32032773", "PMID:32555229" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033031 ; owl:annotatedTarget "An ON diffuse bipolar cell that predominantly connects to ON parasol cells and lateral amacrine cells." . [] oboInOwl:hasDbXref "PMID:32032773" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033031 ; owl:annotatedTarget "DB4 cell" . [] oboInOwl:hasDbXref "PMID:32032773", "PMID:32555229" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033032 ; owl:annotatedTarget "An ON diffuse bipolar cell that has a large dendritic field and large axon terminals, which show little or no overlap. This cell predominantly connects to narrow thorny ganglion cells." . [] oboInOwl:hasDbXref "PMID:32032773" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033032 ; owl:annotatedTarget "DB6 cell" . [] oboInOwl:hasDbXref "PMID:32032773", "PMID:32555229" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033033 ; owl:annotatedTarget "An OFF bipolar cell with a small dendritic tree that provides most of the triad-associated basal (flat) contacts at cone pedicles." . [] oboInOwl:hasDbXref "PMID:32032773" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033033 ; owl:annotatedTarget "FMB cell" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "http://en.wikipedia.org/wiki/Gonadotroph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000437 ; owl:annotatedTarget "A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH)." . [] oboInOwl:hasDbXref "PMID:32032773", "PMID:32555229" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033034 ; owl:annotatedTarget "An ON bipolar cell with a small dendritic tree that forms most of the central (invaginating) elements opposite the synaptic ribbon at the cone triad." . [] oboInOwl:hasDbXref "PMID:32032773" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033034 ; owl:annotatedTarget "IMB cell" . [] oboInOwl:hasDbXref "PMID:32032773", "PMID:32555229" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033035 ; owl:annotatedTarget "An ON bipolar cell that has large dendritic and axonal fields." . [] oboInOwl:hasDbXref "PMID:32032773" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033035 ; owl:annotatedTarget "GB cell" . [] oboInOwl:hasDbXref "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033035 ; owl:annotatedTarget "A giant bipolar cell is usually monostratified, although, very rarely, it can be bistratified." . [] oboInOwl:hasDbXref "PMID:30712875", "PMID:31995762", "PMID:32555229" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033036 ; owl:annotatedTarget "An OFF bipolar cell that is fovea-specific and expresses FEZF1, NXPH1 and NXPH2." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000437 ; owl:annotatedTarget "ZFA:0009202" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:30864819" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033037 ; owl:annotatedTarget "A mucus secreting cell of a submucosal gland of the tracheobronchial tree." . [] oboInOwl:hasDbXref "PMID:24064670", "PMID:31265968" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033038 ; owl:annotatedTarget "An alpha-beta CD4 T cell that resides in the lung." . [] oboInOwl:hasDbXref "PMID:24064670" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033038 ; owl:annotatedTarget "lung resident memory CD4 T cell" . [] oboInOwl:hasDbXref "PMID:31265968" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033038 ; owl:annotatedTarget "lung CD4-positive TRM" . [] oboInOwl:hasDbXref "PMID:28418771", "PMID:31265968" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033039 ; owl:annotatedTarget "An alpha-beta CD8 T cell that resides in the lung." . [] oboInOwl:hasDbXref "PMID:31265968" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033039 ; owl:annotatedTarget "lung CD8-positive TRM" . [] oboInOwl:hasDbXref "PMID:31558615" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033039 ; owl:annotatedTarget "In the lung, CXCR6 regulates the localization of lung resident memory CD8-positive, alpha-beta T cells." . [] oboInOwl:hasDbXref "PMID:27776108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033040 ; owl:annotatedTarget "A lung resident memory CD8-positive, alpha-beta T cell that is CD103-positive." . [] oboInOwl:hasDbXref "PMID:27776108" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033040 ; owl:annotatedTarget "lung TRM CD8-positive, CD103-positive cell" . [] oboInOwl:hasDbXref "PMID:27776108" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033040 ; owl:annotatedTarget "lung TRM CD8-positive, integrin alpha E-positive cell" . [] oboInOwl:hasDbXref "PMID:27776108" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033040 ; owl:annotatedTarget "lung resident memory CD8-positive CD103-positive, alpha-beta T cell" . [] oboInOwl:hasDbXref "PMID:37291214" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033041 ; owl:annotatedTarget "An alveolar macrophage that expresses CCL3." . [] oboInOwl:hasDbXref "PMID:37291214" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033041 ; owl:annotatedTarget "alveolar macrophage CCL3-positive" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033041 ; owl:annotatedTarget "The marker set TNIP3, CXCL5 can identify the Human cell type CCL3-positive alveolar macrophage in the lung with a confidence of 0.67 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "PMID:37291214" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033042 ; owl:annotatedTarget "An alveolar macrophage that expresses metallothionein." . [] oboInOwl:hasDbXref "PMID:37291214" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033042 ; owl:annotatedTarget "alveolar macrophage MT-positive" . [] oboInOwl:hasDbXref "PMID:37291214" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033042 ; owl:annotatedTarget "alveolar macrophage metallothionein-positive" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033042 ; owl:annotatedTarget "The marker set HMOX1, HPGD can identify the Human cell type metallothionein-positive alveolar macrophage in the lung with a confidence of 0.41 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "PMID:33382972", "PMID:35017701", "PMID:36211428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033043 ; owl:annotatedTarget "A macrophage that is part of the lung connective tissue (pulmonary interstitium). This cell performs tissue remodeling and contributes to barrier immunity through antigen presentation." . [] oboInOwl:hasDbXref "PMID:36211428" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033043 ; owl:annotatedTarget "lung IM" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033043 ; owl:annotatedTarget "The marker set F13A1, STAB1, FCGR2B can identify the Human cell type lung interstitial macrophage in the lung with a confidence of 0.46 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "PMID:31558434", "PMID:331922198", "PMID:36883528", "PMID:37291214" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033044 ; owl:annotatedTarget "An epithelial cell part of respiratory tract epithelium that is a precursor of a multi-ciliated cell. This cell actively amplifies centrioles, a required step for multiciliogenesis." . [] oboInOwl:hasDbXref "PMID:31558434", "PMID:331922198", "PMID:36883528" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033044 ; owl:annotatedTarget "In humans, deuterosomal cells have been noted to have enriched expression of the following: PLK4, FOXJ1, DEUP1, FOXN4, YPEL1, HES6 and CDC20B. Deuterosomal cells were termed after deuterosomes, the platforms of active centriole amplification." . [] oboInOwl:hasDbXref "PMID:34516781" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033045 ; owl:annotatedTarget "A dendritic cell that captures antigens in a lung and migrates to a lymph node or to the spleen to activate T cells." . [] oboInOwl:hasDbXref "PMID:34516781" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033045 ; owl:annotatedTarget "lung mDC" . [] oboInOwl:hasDbXref "PMID:34516781" ; oboInOwl:hasSynonymType obo:OMO_0003000, obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033045 ; owl:annotatedTarget "lung mDCs" . [] oboInOwl:hasDbXref "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033046 ; owl:annotatedTarget "A midget ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from invaginating midget bipolar cells." . [] oboInOwl:hasDbXref "PMID:34093409" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033046 ; owl:annotatedTarget "ON-midget RGC" . [] oboInOwl:hasDbXref "PMID:34093409" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033046 ; owl:annotatedTarget "ON-midget cell" . [] oboInOwl:hasDbXref "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033046 ; owl:annotatedTarget "inner stratifying midget cell" . [] oboInOwl:hasDbXref "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033047 ; owl:annotatedTarget "A midget ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from flat midget bipolar cells." . [] oboInOwl:hasDbXref "PMID:34093409" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033047 ; owl:annotatedTarget "OFF-midget RGC" . [] oboInOwl:hasDbXref "PMID:34093409" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033047 ; owl:annotatedTarget "OFF-midget cell" . [] oboInOwl:hasDbXref "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033047 ; owl:annotatedTarget "outer stratifying midget cell" . _:genid18447 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002215 ; owl:someValuesFrom obo:CL_0002633, obo:GO_0061535 . [] oboInOwl:hasDbXref "PMID:25564622", "PMID:34044844", "PMID:35387001", "PMID:37834236" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033048 ; owl:annotatedTarget "A respiratory epithelial cell derived from a basal cell, with a topographic nuclear position between the basal and luminal cells of the airway epithelium. This non-basal, intermediate progenitor cell has limited proliferative capacity and can differentiate into multiciliated, secretory, or rare airway cells (ionocytes, tuft cells, neuroendocrine cells). It shares some ultrastructural features with basal cells but lacks the defined characteristics of fully differentiated cellular phenotypes." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000438 ; owl:annotatedTarget "A peptide hormone secreting cell pituitary that produces luteinizing hormone." . [] oboInOwl:hasDbXref "PMID:25564622" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033048 ; owl:annotatedTarget "respiratory parabasal cell" . [] oboInOwl:hasDbXref "PMID:25658372" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033048 ; owl:annotatedTarget "respiratory suprabasal progenitor cell" . [] oboInOwl:hasDbXref "PMID:25658372", "PMID:32726565", "doi:10.1101/2023.04.20.537495" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033048 ; owl:annotatedTarget "In humans, respiratory tract suprabasal cells have been noted to have enriched expression of the following: CK8, KRT13, IVL, and SERPINB3. Single-cell sequencing indicates that suprabasal cells derived from the nasal epithelium are distinct from those in the tracheobronchial epithelium." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033048 ; owl:annotatedTarget "The marker set TNC, KRT15, SERPINB4 can identify the Human cell type respiratory tract suprabasal cell in the lung with a confidence of 0.62 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "DOI:10.1111/j.1096-3642.1981.tb01137.x", "PMID:10052456", "PMID:28655883", "http://www.nejohnston.org/Birds/documents/AvianTongues_Johnston.pdf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033049 ; owl:annotatedTarget "A taste receptor cell that is part of a taste bud of a tongue." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000438 ; owl:annotatedTarget "ZFA:0009203" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "DOI:10.1016/s0022-5320(69)80043-2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033049 ; owl:annotatedTarget "gustatory cell of tongue" . [] oboInOwl:hasDbXref "ISBN:0521442516", "PMID:12094209" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033050 ; owl:annotatedTarget "A neuron that releases catecholamine as a neurotransmitter." . [] oboInOwl:hasDbXref "PMID:10191060", "PMID:12128258", "PMID:34880760", "https://orcid.org/0000-0002-2244-7917" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033050 ; owl:annotatedTarget "Frequently used when describing the developing nervous system in zebrafish. A catecholaminergic neuron expresses tyrosine hydroxylase (TH), tyrosine hydroxylase 2 (TH2), aromatic amino acid decarboxylase (AADC), dopamine b-hydroxylase (DBH), and phenylethanolamine-N-methyl transferase (PEMT), which are enzymes necessary for catecholamine synthesis." . [] oboInOwl:hasDbXref "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033051 ; owl:annotatedTarget "A parasol ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB3a bipolar cells." . [] oboInOwl:hasDbXref "PMID:34093409" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033051 ; owl:annotatedTarget "OFF-parasol RGC" . [] oboInOwl:hasDbXref "PMID:34093409" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033051 ; owl:annotatedTarget "OFF-parasol retinal ganglion cell" . [] oboInOwl:hasDbXref "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033051 ; owl:annotatedTarget "outer parasol cell" . [] oboInOwl:hasDbXref "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033052 ; owl:annotatedTarget "A parasol ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB4 bipolar cells." . [] oboInOwl:hasDbXref "PMID:34093409" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033052 ; owl:annotatedTarget "ON-parasol RGC" . [] oboInOwl:hasDbXref "PMID:34093409" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033052 ; owl:annotatedTarget "ON-parasol retinal ganglion cell" . [] oboInOwl:hasDbXref "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033052 ; owl:annotatedTarget "inner parasol cell" . [] oboInOwl:hasDbXref "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033053 ; owl:annotatedTarget "A bistratfied retinal ganglion cell with a small dendritic field that has dendrites in the ON and OFF sublamina of the retinal inner plexiform layer and carries blue-ON/yellow-OFF signals. This cell receives bipolar and amacrine input to both the OFF and ON dendritic tree." . [] oboInOwl:hasDbXref "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033053 ; owl:annotatedTarget "small bistratified cell" . [] oboInOwl:hasDbXref "doi:10.1002/cne.22183" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033053 ; owl:annotatedTarget "small bistratified cell, blue-ON/yellow-OFF ganglion cell" . [] oboInOwl:hasDbXref "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033053 ; owl:annotatedTarget "Polyak's shrub cell" . [] oboInOwl:hasDbXref "PMID:32032773" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033053 ; owl:annotatedTarget "SBS ganglion cell" . [] oboInOwl:hasDbXref "PMID:34093409" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033053 ; owl:annotatedTarget "sbRGC" . [] oboInOwl:hasDbXref "PMID:24928499", "PMID:27889329" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033054 ; owl:annotatedTarget "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics." . [] oboInOwl:hasDbXref "PMID:17707699", "PMID:30864819" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033055 ; owl:annotatedTarget "A multi-ciliated epithelial cell located in ciliated duct of an airway submucosal gland, characterized by a columnar shape and motile cilia on its apical surface." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM656.TJVD.294" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4033055 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" . [] oboInOwl:hasDbXref "PMID:24079581", "PMID:28098391", "PMID:30969555", "PMID:34099859", "PMID:39451193" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033056 ; owl:annotatedTarget "A terminally differentiated, specialized keratinocyte originating primarily from the nail matrix. During onychokeratinization, these cells undergo progressive flattening and produce high levels of hard, disulfide cross-linked keratins (Eckhart et al., 2024) that form the rigid, compact nail plate. Unlike epidermal keratinocytes, onychocytes are firmly integrated into the nail plate and do not desquamate." . [] oboInOwl:hasDbXref "PMID:19648928", "PMID:35617956", "https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328", "https://orcid.org/0000-0001-6677-8489" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033057 ; owl:annotatedTarget "A luminal epithelial cell of the mammary gland that can proliferate and has the potential to differentiate into a lactocyte during pregnancy. In humans, a luminal adaptive secretory precursor cell can be identified by high levels of the markers EpCAM and CD49f, and in mice it can be identified by low levels of CD29 and high levels of CD14, Kit, CD61, and Tspan8." . [] oboInOwl:hasDbXref "PMID:35617956" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4033057 ; owl:annotatedTarget "alveolar cell" . [] oboInOwl:hasDbXref "PMID:26390871" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4033057 ; owl:annotatedTarget "alveolar progenitor" . [] oboInOwl:hasDbXref "doi:10.1101/2023.04.21.537845" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4033057 ; owl:annotatedTarget "luminal progenitor" . [] oboInOwl:hasDbXref "PMID:20346151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4033057 ; owl:annotatedTarget "luminal progenitor cell" . [] oboInOwl:hasDbXref "PMID:37380767" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4033057 ; owl:annotatedTarget "luminal secretory cell" . [] oboInOwl:hasDbXref "https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033057 ; owl:annotatedTarget "ER-negative luminal alveolar progenitor" . [] oboInOwl:hasDbXref "https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033057 ; owl:annotatedTarget "AP" . [] oboInOwl:hasDbXref "PMID:35617956" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033057 ; owl:annotatedTarget "AV" . [] oboInOwl:hasDbXref "GOC:tfm", "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000439 ; owl:annotatedTarget "A peptide hormone cell that secretes prolactin." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-6677-8489" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033057 ; owl:annotatedTarget "LASP" . [] oboInOwl:hasDbXref "doi:10.1101/2023.04.21.537845" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033057 ; owl:annotatedTarget "LP" . [] oboInOwl:hasDbXref "PMID:37380767" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033057 ; owl:annotatedTarget "LumSec" . [] oboInOwl:hasDbXref "PMID:19648928", "PMID:26390871", "PMID:34156490", "https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328", "https://orcid.org/0000-0001-6677-8489" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033058 ; owl:annotatedTarget "A luminal epithelial cell of the mammary gland that transduces endocrine cues to orchestrate proliferation, architectural remodeling, and differentiation of other cells in the mammary gland via paracrine signaling. This cell expresses high levels of estrogen receptors. In humans, a luminal hormone-sensing cell can be identified by high levels of EpCAM and low levels of CD49f, and in mice it can be identified by low levels of CD29 and high levels of Foxa1, CD133, and Sca1 (Ly6a)." . [] oboInOwl:hasDbXref "doi:10.1101/2023.04.21.537845" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4033058 ; owl:annotatedTarget "hormone sensing cell" . [] oboInOwl:hasDbXref "PMID:26390871" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4033058 ; owl:annotatedTarget "hormone-sensing mammary epithelial cell" . [] oboInOwl:hasDbXref "PMID:37380767" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4033058 ; owl:annotatedTarget "luminal hormone-responsive cell" . [] oboInOwl:hasDbXref "PMID:20346151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4033058 ; owl:annotatedTarget "luminal mature cell" . [] oboInOwl:hasDbXref "https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033058 ; owl:annotatedTarget "ER-positive luminal hormone-sensor cell" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000439 ; owl:annotatedTarget "ZFA:0009204" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "doi:10.1101/2023.04.21.537845" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033058 ; owl:annotatedTarget "HS" . [] oboInOwl:hasDbXref "PMID:26390871" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033058 ; owl:annotatedTarget "HS-MEC" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-6677-8489" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033058 ; owl:annotatedTarget "LHS" . [] oboInOwl:hasDbXref "PMID:37380767" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033058 ; owl:annotatedTarget "LumHR" . [] oboInOwl:hasDbXref "PMID:26390871", "PMID:34156490", "https://orcid.org/0000-0003-4969-670X" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033058 ; owl:annotatedTarget "Following lineage specification, a luminal hormone-sensing cell expresses receptors for one or more hormones, such as estrogens, progesterone, androgens, and prolactin. In response to progesterone, luminal hormone-sensing cells express TNFSF11, WNT4, and RSPO1, among other factors, which cause branching, proliferation, and partial differentiation in LASP and B-Myo cells during luteal phases of the estrous/menstrual cycle and during gestation. During ductal elongation, ER activity drives expression of AREG in LHS cells, which is necessary for proliferation of the epithelium to fill the mammary fat pad." . [] oboInOwl:hasDbXref "PMID:35091553", "PMID:35377806" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033059 ; owl:annotatedTarget "A lactocyte that highly expresses genes associated with transcription, immune cell function, and cellular stress. A lactocyte type 1 also expresses genes involved in milk component biosynthesis (e.g., LALBA and CSNs), albeit at lower levels than a lactocyte type 2." . [] oboInOwl:hasDbXref "PMID:34097179" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4033059 ; owl:annotatedTarget "luminal cluster 1 cell" . [] oboInOwl:hasDbXref "PMID:35091553" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033059 ; owl:annotatedTarget "LC1" . [] oboInOwl:hasDbXref "PMID:35091553" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033059 ; owl:annotatedTarget "LMC major luminal cluster 1" . [] oboInOwl:hasDbXref "PMID:35091553" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033059 ; owl:annotatedTarget "progenitor MEC" . [] oboInOwl:hasDbXref "PMID:35091553", "PMID:35377806" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033060 ; owl:annotatedTarget "A lactocyte that highly expresses genes associated with lipid production and milk component biosynthesis." . [] oboInOwl:hasDbXref "PMID:35377806" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4033060 ; owl:annotatedTarget "luminal cluster 2 cell" . [] oboInOwl:hasDbXref "PMID:35091553" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033060 ; owl:annotatedTarget "LC2" . [] oboInOwl:hasDbXref "PMID:35091553" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033060 ; owl:annotatedTarget "LMC major luminal cluster 2" . [] oboInOwl:hasDbXref "PMID:28287163" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033061 ; owl:annotatedTarget "An endothelial cell that is part of a central vein of liver." . [] oboInOwl:hasDbXref "PMID:28287163" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4033061 ; owl:annotatedTarget "endothelial cell of central vein" . [] oboInOwl:hasDbXref "PMID:37630754", "doi:10.1007/978-3-030-84725-8" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033062 ; owl:annotatedTarget "A trophoblast cell that invades the uterine wall to anchor the placenta to the uterus. An interstitial extravillous trophoblast cell differentiates from an extravillous trophoblast cell, becoming hyperchromatic and changing its morphology to a fibroblast-like spindle-shaped cell. In humans, this cell can be distinguished by the expression of placental-specific protein 8, which stimulates migration." . [] oboInOwl:hasDbXref "doi:10.1007/978-3-030-84725-8" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033062 ; owl:annotatedTarget "invasive interstitial extravillous trophoblast cell" . [] oboInOwl:hasDbXref "PMID:37630754" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033062 ; owl:annotatedTarget "iEVT" . [] oboInOwl:hasDbXref "PMID:37630754" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033062 ; owl:annotatedTarget "interstitial extravillous trophoblast" . [] oboInOwl:hasDbXref "PMID:11337369" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033062 ; owl:annotatedTarget "interstitial trophoblast" . [] oboInOwl:hasDbXref "PMID:37630754", "doi:10.1007/978-3-030-84725-8" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033063 ; owl:annotatedTarget "A trophoblast cell that invades the maternal spiral arteries and replace the endothelial lining, remodeling the vessels and allowing for adequate blood transport into the placenta. An endovascular extravillous trophoblast cell differentiates from an extravillous trophoblast cell. In humans, this cell can be distinguished by the expression of CD56." . [] oboInOwl:hasDbXref "PMID:37630754" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033063 ; owl:annotatedTarget "eEVT" . [] oboInOwl:hasDbXref "PMID:37630754" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033063 ; owl:annotatedTarget "endovascular extravillous trophoblast" . [] oboInOwl:hasDbXref "PMID:11337369" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033063 ; owl:annotatedTarget "endovascular trophoblast" . _:genid18562 oboInOwl:hasDbXref "PMID:37630754" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033063 ; owl:annotatedTarget "Shortly after implantation, the endovascular extravillous trophoblast cells occlude the maternal spiral arteries, preventing premature oxygen delivery to the placental villi and reducing fetal oxidative stress." ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061535 . [] oboInOwl:hasDbXref "PMID:36113384" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033064 ; owl:annotatedTarget "A tissue-resident macrophage that is part of the uterus." . [] oboInOwl:hasDbXref "PMID:36113384" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4033064 ; owl:annotatedTarget "uterine macrophage" . [] oboInOwl:hasDbXref "PMID:36113384" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033064 ; owl:annotatedTarget "Uterine macrophages are reported to be evenly distributed throughout the endometrial stroma but with aggregations observed close to the lumen of superficial secretory glands." . [] oboInOwl:hasDbXref "PMID:21918187", "PMID:30755708", "PMID:33150420" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033065 ; owl:annotatedTarget "A mature B cell that serves as an intermediate stage in the differentiation of naive B cells into a plasmablast. A preplasmablast expresses CD30 and IL-6R and lacks expression of CD20, CD23, CD38 and CD138." . [] oboInOwl:hasDbXref "PMID:23613519" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033065 ; owl:annotatedTarget "pre-plasmablast" . [] oboInOwl:hasDbXref "PMID:33661294" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033065 ; owl:annotatedTarget "preplasmablastic cell" . [] oboInOwl:hasDbXref "PMID:21918187" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033065 ; owl:annotatedTarget "prePB" . [] oboInOwl:hasDbXref "PMID:17639032", "PMID:32759216", "PMID:33970370", "PMID:38178246" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033066 ; owl:annotatedTarget "A supporting cell that is part of the ovary and differentiates into a granulosa cell. A pre-granulosa cell develops from an early supporting gonadal cell by repressing testis determination, which can then proliferate to form primordial follicles." . [] oboInOwl:hasDbXref "PMID:32759216" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033066 ; owl:annotatedTarget "ovarian pregranulosa cell" . [] oboInOwl:hasDbXref "PMID:17639032", "PMID:32759216" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033066 ; owl:annotatedTarget "pregranulosa cell" . [] oboInOwl:hasDbXref "PMID:32759216" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033066 ; owl:annotatedTarget "PG cell" . [] oboInOwl:hasDbXref "PMID:27815559", "PMID:33970370", "PMID:34198768" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033067 ; owl:annotatedTarget "A follicular cell of ovary that differentiates from a cuboidal granulosa cell during the secondary follicle stage. Mural granulosa cells line the inner surface of the follicle wall, surrounding the fluid-filled antral cavity. These cells produce oestrogen during the follicular phase in response to follicle-stimulating hormone (FSH), and progesterone after ovulation in response to luteinizing hormone (LH)." . [] oboInOwl:hasDbXref "doi:10.1530/REP-16-0500" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033067 ; owl:annotatedTarget "MGC" . [] oboInOwl:hasDbXref "PMID:34198768" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033067 ; owl:annotatedTarget "mural GC" . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000440 ; owl:annotatedTarget "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." . [] oboInOwl:hasDbXref "PMID:31348891" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033068 ; owl:annotatedTarget "A(n) B cell that is cycling." . [] oboInOwl:hasDbXref "PMID:31348891" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033068 ; owl:annotatedTarget "proliferating B cell" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000440 ; owl:annotatedTarget "ZFA:0009205" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:37291214" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033069 ; owl:annotatedTarget "A(n) T cell that is cycling." . [] oboInOwl:hasDbXref "PMID:37291214" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033069 ; owl:annotatedTarget "proliferating T cell" . [] obo:IAO_0000233 "https://github.com/obophenotype/cell-ontology/issues/1943" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000441 ; owl:annotatedTarget _:genid1645 . [] oboInOwl:hasDbXref "PMID:32066951" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033070 ; owl:annotatedTarget "A(n) dendritic cell that is cycling." . [] oboInOwl:hasDbXref "PMID:32066951" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033070 ; owl:annotatedTarget "proliferating dendritic cell" . [] oboInOwl:hasDbXref "doi:10.1016/B978-012369493-5.50005-5", "doi:10.1038/s41467-020-19361-0", "doi:10.1242/dev.121.11.3797" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000441 ; owl:annotatedTarget "A stem cell that gives rise to the follicle cells that surround the oocyte in female arthropods." . [] oboInOwl:hasDbXref "PMID:34062119" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033071 ; owl:annotatedTarget "A(n) natural killer cell that is cycling." . [] oboInOwl:hasDbXref "PMID:34062119" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033071 ; owl:annotatedTarget "proliferating natural killer cell" . [] oboInOwl:hasDbXref "doi:10.1016/j.devcel.2005.08.012" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000441 ; owl:annotatedTarget "somatic stem cell" . [] oboInOwl:hasDbXref "PMID:32066951" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033072 ; owl:annotatedTarget "A(n) gamma-delta T cell that is cycling." . [] oboInOwl:hasDbXref "PMID:32066951" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033072 ; owl:annotatedTarget "proliferating gamma-delta T cell" . [] oboInOwl:hasDbXref "PMID:31348891" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033073 ; owl:annotatedTarget "A(n) monocyte that is cycling." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000441 ; owl:annotatedTarget "FBbt:00004903" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:31348891" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033073 ; owl:annotatedTarget "proliferating monocyte" . [] oboInOwl:hasDbXref "PMID:34062119" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033074 ; owl:annotatedTarget "A(n) CD8-positive, alpha-beta T cell that is cycling." . [] oboInOwl:hasDbXref "PMID:34062119" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033074 ; owl:annotatedTarget "proliferating CD8-positive, alpha-beta T cell" . [] oboInOwl:hasDbXref "ISBN:127520252" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000442 ; owl:annotatedTarget "A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response." . [] oboInOwl:hasDbXref "PMID:34062119" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033075 ; owl:annotatedTarget "A(n) CD4-positive, alpha-beta T cell that is cycling." . [] oboInOwl:hasDbXref "PMID:34062119" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033075 ; owl:annotatedTarget "proliferating CD4-positive, alpha-beta T cell" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM355.ZFMS.256" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000442 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-red-pulp/v1.2/assets/2d-ftu-spleen-red-pulp.png" . [] oboInOwl:hasDbXref "PMID:33208946" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033076 ; owl:annotatedTarget "A(n) macrophage that is cycling." . [] oboInOwl:hasDbXref "PMID:33208946" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033076 ; owl:annotatedTarget "proliferating macrophage" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM559.FNBB.6273" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000442 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-white-pulp/v1.2/assets/2d-ftu-spleen-white-pulp.png" . [] oboInOwl:hasDbXref "PMID:37291214" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033077 ; owl:annotatedTarget "A(n) alveolar macrophage that is cycling." . [] oboInOwl:hasDbXref "PMID:37291214" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033077 ; owl:annotatedTarget "proliferating alveolar macrophage" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033077 ; owl:annotatedTarget "The marker set PCLAF, RRM2, UBE2C, NUSAP1 can identify the Human cell type cycling alveolar macrophage in the lung with a confidence of 0.26 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "PMID:37468583" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033078 ; owl:annotatedTarget "A(n) mononuclear phagocyte that is cycling." . [] oboInOwl:hasDbXref "PMID:37468583" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033078 ; owl:annotatedTarget "proliferating mononuclear phagocyte" . [] oboInOwl:hasDbXref "PMID:37291214" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033079 ; owl:annotatedTarget "A(n) endothelial cell of lymphatic vessel that is cycling." . [] oboInOwl:hasDbXref "PMID:37291214" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033079 ; owl:annotatedTarget "proliferating endothelial cell of lymphatic vessel" . [] oboInOwl:hasDbXref "PMID:37291214" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033080 ; owl:annotatedTarget "A(n) pulmonary alveolar type 2 cell that is cycling." . [] oboInOwl:hasDbXref "PMID:37291214" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033080 ; owl:annotatedTarget "proliferating pulmonary alveolar type 2 cell" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033080 ; owl:annotatedTarget "The marker set PEG10, PRC1, TOP2A can identify the Human cell type cycling pulmonary alveolar type 2 cell in the lung with a confidence of 0.61 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "PMID:38301653" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033081 ; owl:annotatedTarget "A(n) myeloid cell that is cycling." . [] oboInOwl:hasDbXref "PMID:38301653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033081 ; owl:annotatedTarget "proliferating myeloid cell" . [] oboInOwl:hasDbXref "PMID:33208946" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033082 ; owl:annotatedTarget "A(n) basal cell that is cycling." . [] oboInOwl:hasDbXref "PMID:33208946" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033082 ; owl:annotatedTarget "proliferating basal cell" . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000443 ; owl:annotatedTarget "Any secretory cell that is capable of some calcitonin secretion." . [] oboInOwl:hasDbXref "PMID:28892263" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033083 ; owl:annotatedTarget "A granulosa cell that has a squamous morphology and form a single layer around the oocyte in primordial follicles. This cell develops directly into a cuboidal granulosa cell during the primordial-to-primary follicle transition." . [] oboInOwl:hasDbXref "PMID:22402964" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033083 ; owl:annotatedTarget "flattened granulosa cell" . [] oboInOwl:hasDbXref "PMID:33914868" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033083 ; owl:annotatedTarget "pre-granulosa cell" . [] oboInOwl:hasDbXref "PMID:33914868" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033083 ; owl:annotatedTarget "squamous GC" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-6677-8489" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033083 ; owl:annotatedTarget "Often in literature squamous granulosa cell and pre-granulosa cell are used as synonyms. However, this term only makes reference to the quiescent granulosa cells that surround the primordial ovarian follicle, while a pre-granulosa cell proliferates to form the primordial follicle (and thus cells become the squamous granulosa cells)." . [] oboInOwl:hasDbXref "PMID:28892263" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033084 ; owl:annotatedTarget "A granulosa cell that has a cuboidal morphology and develops from squamous granulosa cell during the transition between primordial follicle to primary follicle. Cuboidal granulosa cells proliferate to form a second layer within secondary follicles." . [] oboInOwl:hasDbXref "PMID:19001500" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033084 ; owl:annotatedTarget "columnar granulosa cell" . [] oboInOwl:hasDbXref "PMID:31849844" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033084 ; owl:annotatedTarget "cuboidal epithelial granulosa cell" . [] oboInOwl:hasDbXref "PMID:19001500" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033084 ; owl:annotatedTarget "columnar GC" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000443 ; owl:annotatedTarget "ZFA:0009206" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:33914868" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033084 ; owl:annotatedTarget "cuboidal GC" . [] oboInOwl:hasDbXref "PMID:27833534", "PMID:32032773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033085 ; owl:annotatedTarget "An ON diffuse bipolar cell that stratifies in the stratum 3 of the inner plexiform layer to make synapses with ON parasol ganglion cells. A diffuse bipolar 5 cell has high expression of MYO16 compared with other bipolar cells." . [] oboInOwl:hasDbXref "PMID:32032773" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033085 ; owl:annotatedTarget "DB5 cell" . [] oboInOwl:hasDbXref "PMID:27833534" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033085 ; owl:annotatedTarget "A diffuse bipolar 5 cell typically contacts 7–8 cone photoreceptors. The number and thickness of its dendritic processes are intermediate between those of a diffuse bipolar 6 cell (less dense and thinner) and a diffuse bipolar 4 cell (denser and thicker)." . [] oboInOwl:hasDbXref "PMID:31257031", "PMID:34876704", "PMID:35712121" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033086 ; owl:annotatedTarget "A tissue-resident macrophage that is associated with lipids. This cell responsible of anti-inflammatory functions, lipid accumulation and enhancing phagocytosis (Wculek et al., 2022, Liu et al., 2022). In mice and humans, a lipid-associated macrophage is characterized by the marker Trem2 (Jaitlin et al., 2019)." . [] oboInOwl:hasDbXref "PMID:31257031" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033086 ; owl:annotatedTarget "LAM" . [] oboInOwl:hasDbXref "PMID:35021063", "PMID:37153549" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033086 ; owl:annotatedTarget "Distinct from “adipose macrophage” in Trem2 expression, and is not limited to adipose tissue. Guilliams et al. describe these cells as being distinct from Kupffer cells." . [] oboInOwl:hasDbXref "PMID:39007150" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033087 ; owl:annotatedTarget "A tissue-resident macrophage that is part of the placenta. This cell helps preventing immunological rejection of the fetus by modulating the immune environment. A placental resident macrophage has high plasticity to adapt to the changing needs of each phase of pregnancy." . [] oboInOwl:hasDbXref "PMID:39007150" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4033087 ; owl:annotatedTarget "placental macrophage" . [] oboInOwl:hasDbXref "PMID:39007150" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033088 ; owl:annotatedTarget "A resident macrophage that is part of the decidua. Some decidual macrophages are derived from maternal blood monocytes that are recruited to the uterus shortly after conception. The main functions of a decidual macrophage are implantation, placental development, immune regulation and vascular remodeling." . [] oboInOwl:hasDbXref "PMID:39007150" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4033088 ; owl:annotatedTarget "decidual macrophage" . [] oboInOwl:hasDbXref "PMID:39007150" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4033088 ; owl:annotatedTarget "maternal decidual macrophage" . [] oboInOwl:hasDbXref "PMID:38069168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033089 ; owl:annotatedTarget "A follicular cell of ovary that has begun to degenerate and undergo atresia, a specialized apoptosis. This cell is found in an atretic follicle, which is an ovarian follicle that started to mature but failed to reach full development and instead regresses." . [] oboInOwl:hasDbXref "PMID:15353131", "PMID:38069168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033090 ; owl:annotatedTarget "A granulosa cell that is undergoing atresia. This cell type displays distinct morphological alterations compared with a healthy granulosa cell, including pyknosis (nuclear condensation) and cellular shrinkage." . [] oboInOwl:hasDbXref "PMID:15353131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033090 ; owl:annotatedTarget "apoptotic granulosa cell" . [] oboInOwl:hasDbXref "PMID:37124720" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033091 ; owl:annotatedTarget "An amacrine cell that uses both GABA and glycine as neurotransmitters." . [] oboInOwl:hasDbXref "PMID:37124720" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033091 ; owl:annotatedTarget "glycinergic/GABAergic amacrine neuron" . [] oboInOwl:hasDbXref "PMID:37468586" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033092 ; owl:annotatedTarget "An enterocyte that is part of a duodenal epithelium and expresses beta-1,3-glucuronyltransferase 1 (B3GAT1), also known as CD57 or HNK-1." . [] oboInOwl:hasDbXref "PMID:37468586" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033092 ; owl:annotatedTarget "CD57+ enterocyte" . [] oboInOwl:hasDbXref "PMID:37468586" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033092 ; owl:annotatedTarget "While CD57 is traditionally associated with immune cells (e.g., NK cells), its expression on enterocytes marks unique epithelial subsets with specific functions or maturation states. These cells are specially enriched in areas of the duodenum within submucosal glands." . [] oboInOwl:hasDbXref "PMID:20614614", "PMID:29105366", "PMID:36983561", "PMID:37768272" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033093 ; owl:annotatedTarget "A stem cell that is part of the corneo-scleral limbus. This cell type resides at the basal layer of the epithelium and has a small size and high nuclear to cytoplasmatic ratio (Secker and Daniels, 2009). A limbal stem cell is responsible for corneal epithelial renewal and repair (Li et al., 2023), and to help maintain a clear corneal surface by preventing conjunctival epithelial cells from migrating onto the cornea (Wang et al., 2023)." . [] oboInOwl:hasDbXref "PMID:20614614" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033093 ; owl:annotatedTarget "limbal epithelial stem cell" . [] oboInOwl:hasDbXref "PMID:17562792" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033093 ; owl:annotatedTarget "limbal stem cell" . [] oboInOwl:hasDbXref "PMID:20614614" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033093 ; owl:annotatedTarget "LESC" . [] oboInOwl:hasDbXref "PMID:36983561" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033093 ; owl:annotatedTarget "LSC" . [] oboInOwl:hasDbXref "PMID:30873171", "PMID:31986068", "PMID:35298565", "PMID:35798993" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033094 ; owl:annotatedTarget "A transcriptionally distinct memory B cell whose presence increases with age, during infections, and in autoimmune diseases. In humans and mice, this cell type can be identified by the expression of T-bet, CD11c, CD11b, and the lack of CD21. An age-associated B cell responds to TLR stimuli, may produce autoantibodies, and participates in antiviral responses and pathogen clearance." . [] oboInOwl:hasDbXref "PMID:35798993" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033094 ; owl:annotatedTarget "ABC" . [] oboInOwl:hasDbXref "PMID:31995762", "doi:10.1101/2023.11.07.566105" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033095 ; owl:annotatedTarget "An ON bipolar cell that has high expression of DIRC3, KCNJ3, LINC01915, PTPRK compared with other bipolar cells." . [] oboInOwl:hasDbXref "doi:10.1101/2023.11.07.566105" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033095 ; owl:annotatedTarget "DB4a" . [] oboInOwl:hasDbXref "PMID:31995762", "doi:10.1101/2023.11.07.566105" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033096 ; owl:annotatedTarget "An ON bipolar cell that has high expression of NOS1AP compared with other bipolar cells." . [] oboInOwl:hasDbXref "doi:10.1101/2023.11.07.566105" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033096 ; owl:annotatedTarget "DB4b" . [] oboInOwl:hasDbXref "PMID:25051267" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033097 ; owl:annotatedTarget "SC endothelial cell" . [] oboInOwl:hasDbXref "PMID:25051267" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033097 ; owl:annotatedTarget "SEC" . [] dc:license ; oboInOwl:hasDbXref "PMID:26402712" ; a owl:Axiom ; rdfs:comment "Schematic of the conventional outflow pathway, showing the Schlemm's canal (SC, green) and the trabecular meshwork (TM, orange). The left inset shows an expanded view of the Schlemm’s canal’s microanatomy detailing the cell morphology of the inner and outer wall endocrine cells." ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4033097 ; owl:annotatedTarget "http://purl.obolibrary.org/obo/cl/images/Schlemms_canal_endo_cell_PMID26402712.png"^^xsd:anyURI . [] oboInOwl:hasDbXref "PMID:15454474", "PMID:26402712" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033098 ; owl:annotatedTarget "A Schlemm's canal endothelial cell that lines the inner wall of the Schlemm's canal. This cell exhibits a cobblestone appearance due to the significant biomechanical load it experiences, as well as the segmental flow of aqueous humor. The degree of biomechanical stress can lead to the formation of dome-like outpouchings known as giant vacuoles. In addition, the cell contains transcellular pores that mediate aqueous humor transport (Dautriche et al., 2015). This endothelial cell also displays prominent peripheral F-actin bands which help maintain structural integrity under pressure (Ethier et al., 2004)." . [] oboInOwl:hasDbXref "PMID:26402712" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_4033098 ; owl:annotatedTarget "human Schlemm's canal inner wall cell" . [] oboInOwl:hasDbXref "PMID:26402712" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033098 ; owl:annotatedTarget "HSCIW cell" . [] dc:license ; oboInOwl:hasDbXref "PMID:26402712" ; a owl:Axiom ; rdfs:comment "Schematic of the conventional outflow pathway, showing the Schlemm's canal (SC, green) and the trabecular meshwork (TM, orange). The left inset shows an expanded view of the Schlemm’s canal’s microanatomy detailing the cell morphology of the inner and outer wall endocrine cells. The inner wall endocrine cells, shown in blue, line the canal surface facing the trabecular meshwork. Some of the inner wall cells contain giant vacuoles." ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4033098 ; owl:annotatedTarget "http://purl.obolibrary.org/obo/cl/images/Schlemms_canal_endo_cell_PMID26402712.png"^^xsd:anyURI . [] oboInOwl:hasDbXref "GOC:DOS", "PMID:8720463" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000444 ; owl:annotatedTarget "A muscle cell in which the fibers are organised into sarcomeres but in which adjacent myofibrils are offset from each other, producing an oblique banding pattern." . [] oboInOwl:hasDbXref "PMID:1426078", "PMID:15454474", "PMID:26402712" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033099 ; owl:annotatedTarget "A Schlemm's canal endothelial cell that lines the outer wall of the Schlemm's canal. This cell displays a smooth and flat morphology (Dautriche et al., 2015) and it is distinguished by the presence of Weibel-Palade bodies, specialized organelles that produce, store, and release P-Selectin (Hamanaka et al., 1992). This endothelial cell also exhibits stellate (star-shaped) actin arrangements distributed throughout much of the cell (Ethier et al., 2004)." . [] dc:license ; oboInOwl:hasDbXref "PMID:26402712" ; a owl:Axiom ; rdfs:comment "Schematic of the conventional outflow pathway, showing the Schlemm's canal (SC, green) and the trabecular meshwork (TM, orange). The left inset shows an expanded view of the Schlemm’s canal’s microanatomy detailing the cell morphology of the inner and outer wall endocrine cells. The outer wall endocrine cells, shown in green, line the side of Schlemm’s canal facing the collector channels and venous system." ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4033099 ; owl:annotatedTarget "http://purl.obolibrary.org/obo/cl/images/Schlemms_canal_endo_cell_PMID26402712.png"^^xsd:anyURI . [] oboInOwl:hasDbXref "FBC:Autogenerated", "PMID:38687681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033100 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the atrial intrinsic cardiac ganglion and expresses the marker tyrosine hydroxylase (TH)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/0006-8993(92)90591-V" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033101 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/j.tice.2019.04.006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033102 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker tyrosine hydroxylase (TH)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/0006-8993(92)90591-V" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033103 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker neuropeptide Y (NPY)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/0006-8993(92)90591-V", "doi:10.1016/S0304-3940(99)00115-9", "doi:10.1016/j.tice.2019.04.006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033104 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/0006-8993(92)90591-V" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033105 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker somatostatin (SST)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/0006-8993(92)90591-V", "doi:10.1016/j.tice.2019.04.006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033106 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker vasoactive intestinal peptide (VIP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "PMID:29154859", "doi:10.1016/0006-8993(92)90591-V" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033107 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker calcitonin gene-related peptide (CGRP)." . [] oboInOwl:hasDbXref "FMA:69078", "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000446 ; owl:annotatedTarget "An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/j.tice.2019.04.006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033108 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker dopamine beta-hydroxylase (DBH)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/j.tice.2019.04.006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033109 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker tyrosine hydroxylase (TH)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/j.tice.2019.04.006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033110 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/j.tice.2019.04.006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033111 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker neuropeptide Y (NPY)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/j.tice.2019.04.006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033112 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker vasoactive intestinal peptide (VIP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/0306-4522(81)90126-3" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033113 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker enkephalin." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/j.tice.2019.04.006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033114 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker tyrosine hydroxylase (TH)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/j.tice.2019.04.006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033115 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/j.tice.2019.04.006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033116 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker vasoactive intestinal peptide (VIP)." . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D052438" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000448 ; owl:annotatedTarget "An adipocyte with light coloration and few mitochondria. It contains a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1172/jci.insight.94715" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033117 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker vesicular acetylcholine transporter (VAChT)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/0306-4522(81)90126-3" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033118 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the thoracic ganglion and expresses the marker enkephalin." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1073/pnas.86.11.4302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033119 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the thoracic ganglion and expresses the marker tyrosine hydroxylase (TH)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1073/pnas.86.11.4302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033120 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the thoracic ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1007/BF00508311" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033121 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker vasoactive intestinal peptide (VIP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1007/BF00215411" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033122 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker somatostatin (SST) and tyrosine hydroxylase (TH)." . _:genid18900 a owl:Restriction ; owl:onProperty obo:RO_0002215, obo:RO_0002292 ; owl:someValuesFrom obo:GO_0061535, obo:PR_000011387 . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1007/BF01885786" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033123 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1007/BF01885786" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033124 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker tyrosine hydroxylase (TH)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1007/BF01885786" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033125 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker neuropeptide Y (NPY)." . [] oboInOwl:hasDbXref "MESH:D002001" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000449 ; owl:annotatedTarget "A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/j.eururo.2005.02.010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033126 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the sacral ganglion and expresses the marker tyrosine hydroxylase (TH)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1111/j.1749-6632.1996.tb17547.x" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033127 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the lower airway ganglion and expresses the marker choline O-acetyltransferase (ChAT) and vasoactive intestinal peptide (VIP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/0167-0115(93)90051-9", "doi:10.1016/0891-0618(93)90030-8" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033128 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker vasoactive intestinal peptide (VIP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/0167-0115(93)90051-9", "doi:10.1016/0891-0618(93)90030-8" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033129 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker peptide histidine isoleucine (PHI)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/0167-0115(93)90051-9", "doi:10.1016/0891-0618(93)90030-8", "doi:10.1111/j.1749-6632.1992.tb22804.x" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033130 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker calcitonin gene-related peptide (CGRP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "PMID:2455503", "doi:10.1016/0167-0115(93)90051-9", "doi:10.1016/0891-0618(93)90030-8" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033131 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker substance P (SP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/0167-0115(93)90051-9", "doi:10.1016/0891-0618(93)90030-8" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033132 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker somatostatin (SOM)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/0167-0115(93)90051-9", "doi:10.1016/0891-0618(93)90030-8" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033133 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker somatostatin (SOM) and calcitonin gene-related peptide (CGRP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "PMID:2455503" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033134 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the superior mesenteric ganglion and expresses the marker substance P (SP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1111/joa.12436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033135 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the inferior mesenteric ganglion and expresses the marker tyrosine hydroxylase (TH)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "PMID:2455503" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033136 ; owl:annotatedTarget "A sympathetic neuron that has the soma located in the inferior mesenteric ganglion and expresses the marker substance P (SP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1002/ar.21516", "doi:10.1016/S0006-8993(99)01260-3" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033137 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the otic ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/S0006-8993(99)01260-3" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033138 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the otic ganglion and expresses the marker vasoactive intestinal peptide (VIP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1002/ar.21516" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033139 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the ciliary ganglion and expresses the marker vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1002/ar.21516", "doi:10.1016/0006-8993(95)00299-6" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033140 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the ciliary ganglion and expresses the marker tyrosine hydroxylase (TH)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1002/ar.21516" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033141 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the submandibular ganglion and expresses the marker tyrosine hydroxylase (TH)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1002/ar.21516" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033142 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the submandibular ganglion and expresses the marker vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1002/ar.21516" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033143 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the submandibular ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1002/ar.21516" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033144 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the pterygopalatine ganglion and expresses the marker vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/S0006-8993(99)01260-3" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033145 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the pterygopalatine ganglion and expresses the marker vasoactive intestinal peptide (VIP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1002/ar.21516", "doi:10.1016/S0006-8993(99)01260-3" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033146 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the pterygopalatine ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.3109/00016489609137839" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033147 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the vestibular ganglion and expresses the marker substance P (SP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1007/s10571-014-0062-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033148 ; owl:annotatedTarget "A sensory neuron that has the soma located in the nodose ganglion and expresses the marker transient receptor potential vanilloid 1 (TRPV1)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1007/s10571-014-0062-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033149 ; owl:annotatedTarget "A sensory neuron that has the soma located in the nodose ganglion and expresses the marker purinergic receptor P2X3 (P2X3)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1007/s10571-014-0062-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033150 ; owl:annotatedTarget "A sensory neuron that has the soma located in the nodose ganglion and expresses the marker transient receptor potential vanilloid 2 (TRPV2)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1007/s10571-014-0062-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033151 ; owl:annotatedTarget "A sensory neuron that has the soma located in the nodose ganglion and expresses the marker parvalbumin (PVALB)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/j.tice.2020.101344" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033152 ; owl:annotatedTarget "A sensory neuron that has the soma located in the jugular ganglion and expresses the marker transient receptor potential vanilloid 1 (TRPV1)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/j.tice.2020.101344" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033153 ; owl:annotatedTarget "A sensory neuron that has the soma located in the jugular ganglion and expresses the marker transient receptor potential vanilloid 2 (TRPV2)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/j.tice.2020.101344" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033154 ; owl:annotatedTarget "A sensory neuron that has the soma located in the jugular ganglion and expresses the marker substance P (SP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/j.tice.2020.101344" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033155 ; owl:annotatedTarget "A sensory neuron that has the soma located in the jugular ganglion and expresses the marker calcitonin gene-related peptide (CGRP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/j.tice.2020.101344" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033156 ; owl:annotatedTarget "A sensory neuron that has the soma located in the jugular ganglion and expresses the marker SPARC-like protein 1 (SPARCL1)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1159/000470835" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033157 ; owl:annotatedTarget "A sensory neuron that has the soma located in the geniculate ganglion and expresses the marker transient receptor potential vanilloid 1 (TRPV1)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1159/000470835" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033158 ; owl:annotatedTarget "A sensory neuron that has the soma located in the geniculate ganglion and expresses the marker SPARC-like protein 1 (SPARCL1)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1159/000470835" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033159 ; owl:annotatedTarget "A sensory neuron that has the soma located in the geniculate ganglion and expresses the marker vesicular glutamate transporter 2 (VGLUT2)." . _:genid19007 a owl:Restriction ; owl:onProperty obo:RO_0002100, obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000031, obo:UBERON_8600119 . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1007/s00418-021-02002-y", "doi:10.1016/j.jcmgh.2023.06.010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033160 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker choline O-acetyltransferase (ChAT)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1007/s00418-021-02002-y ", "doi:10.1016/j.jcmgh.2023.06.010", "doi:10.1159/000320542" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033161 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/j.jcmgh.2023.06.010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033162 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker vasoactive intestinal peptide (VIP)." . [] oboInOwl:hasDbXref "10.1007/s00418-005-0107-8", "FBC:Autogenerated", "doi:10.1007/s00418-021-02002-y", "doi:10.1159/000320542" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033163 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS) and vasoactive intestinal peptide (VIP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1007/s00418-021-02002-y", "doi:10.1007/s00441-009-0852-4" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033164 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS) and choline O-acetyltransferase (ChAT)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1007/s00418-007-0335-1", "doi:10.1007/s00418-021-02002-y" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033165 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker choline acetyltransferase (ChAT), calreticulin (CALR), somatostatin (SOM), and substance P (SP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1159/000320542" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033166 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker vasoactive intestinal peptide (VIP) and galanin (GAL)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1016/j.eururo.2005.02.010", "doi:10.1111/j.1469-7580.2009.01071.x", "doi:10.1186/s12894-018-0369-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033167 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker tyrosine hydroxylase (TH)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1007/s00441-020-03279-6" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033168 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1111/j.1469-7580.2009.01071.x" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033169 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker vesicular acetylcholine transporter (VAChT)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1002/(SICI)1520-6777(2000)19:2%3C185::AID-NAU9%3E3.0.CO;2-2", "doi:10.1186/s12894-018-0369-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033170 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1186/s12894-018-0369-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033171 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase (nNOS) 1 and vasoactive intestinal peptide (VIP)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1002/(SICI)1520-6777(2000)19:2%3C185::AID-NAU9%3E3.0.CO;2-2" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033172 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker neuropeptide Y (NPY) and vesicular acetylcholine transporter (VAChT)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1002/(SICI)1520-6777(2000)19:2<185::AID-NAU9>3.0.CO;2-2" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033173 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase 1(nNOS) and vesicular acetylcholine transporter (VAChT)." . [] oboInOwl:hasDbXref "FBC:Autogenerated", "doi:10.1111/joa.12436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033174 ; owl:annotatedTarget "A peripheral nervous system neuron that has the soma located in the ovarian nerve plexus ganglion and expresses the marker tyrosine hydroxylase (TH)." . [] oboInOwl:hasDbXref "PMID:10719353" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4040000 ; owl:annotatedTarget "A glial precursor cell that generates oligodendrocytes and type-1 and type-2 astrocytes. It has been shown in some mammals that this cell type may express A2B5, nestin, FGFR-1, FGFR-2, FGFR-3, PLP, and DM-20 antigens. Unlike oligodendrocyte precursor cell, it does not initially express PDGFR-alpha and can differentiate into both type-1 and type-2 astrocytes." . [] oboInOwl:hasDbXref "PMID:10719353" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4040000 ; owl:annotatedTarget "glial restricted precursor" . [] oboInOwl:hasDbXref "PMID:11921204" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4040000 ; owl:annotatedTarget "tripotential glial-restricted precursor cell" . [] oboInOwl:hasDbXref "PMID:11756508" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4040000 ; owl:annotatedTarget "GRP cell" . [] oboInOwl:hasDbXref "PMID:27280409", "PMID:35328607" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4040001 ; owl:annotatedTarget "A horse-specific, highly invasive trophoblast cell that invades the endometrium where it forms endometrial cups." . [] oboInOwl:hasDbXref "PMID:35328607" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4040001 ; owl:annotatedTarget "equine chorionic girdle cell" . [] oboInOwl:hasDbXref "PMID:27280409" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4040001 ; owl:annotatedTarget "Humans, mice and rats have a highly invasive (hemochorial) placentation. Horses have a non-invasive epitheliochorial placenta, except for the transient endometrial cup." . [] oboInOwl:hasDbXref "PMID:16336493", "PMID:17483847", "PMID:25975510" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4040002 ; owl:annotatedTarget "Glial cell that provides support to the enteric nervous system. It is involved in enteric neurotransmission, in maintaining the integrity of the mucosal barrier of the gut and serves as a link between the nervous and immune systems of the gut. In enteric nerve strands, glial processes ensheath multiaxonal bundles which distinguishes enteric glia from all other peripheral glia. Ultrastructurally, the most conspicuous trait of an enteroglial cell is the presence of 10 nm filaments, which criss-cross the cell body, form axial bundles in the processes and appear to firmly anchor the cells to the ganglionic surfaces. Similar to astrocytes, their main constituent is glial fibrillary acidic protein (GFAP)." . [] oboInOwl:hasDbXref "PMID:11169131", "PMID:25170211" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4040002 ; owl:annotatedTarget "enteric glial cell" . [] oboInOwl:hasDbXref "PMID:11169131" ; oboInOwl:hasSynonymType obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4040002 ; owl:annotatedTarget "enteric glia" . [] oboInOwl:hasDbXref "PMID:1316350" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4040003 ; owl:annotatedTarget "Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity." . [] oboInOwl:hasDbXref "PMID:9624168" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4040003 ; owl:annotatedTarget "fetal alveolar pre-type II epithelial cell" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4040003 ; owl:annotatedTarget "fetal pre-type 2 pneumocyte" . [] oboInOwl:hasDbXref "PMID:12114192" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4040003 ; owl:annotatedTarget "fetal pre-type II alveolar epithelial cell" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4040004 ; owl:annotatedTarget "Any mesenchymal stem cell of adipose tissue that is part of an orbital region." . [] oboInOwl:hasDbXref "PMID:31377878" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4040004 ; owl:annotatedTarget "OAMSC" . [] oboInOwl:hasDbXref "PMID:30210548" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4040004 ; owl:annotatedTarget "Orbital ASCs" . [] oboInOwl:hasDbXref "PMID:31377878" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4040004 ; owl:annotatedTarget "orbital adipose-derived mesenchymal stem cell" . [] oboInOwl:hasDbXref "PMID:30834270", "PMID:34026757" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4040005 ; owl:annotatedTarget "A mesenchymal stem cell that is part of the apical papilla tooth root." . [] oboInOwl:hasDbXref "PMID:30834270" ; oboInOwl:hasSynonymType obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4040005 ; owl:annotatedTarget "stem cells from the apical papilla" . [] oboInOwl:hasDbXref "PMID:37887345" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4040005 ; owl:annotatedTarget "SCAP" . [] oboInOwl:hasDbXref "PMID:30834270" ; oboInOwl:hasSynonymType obo:OMO_0003000, obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4040005 ; owl:annotatedTarget "SCAPs" . [] oboInOwl:hasDbXref "PMID:34026757" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4040005 ; owl:annotatedTarget "The mesenchymal stem cells of the apical papilla have high capacity for osteogenic, adipogenic, and chondrogenic differentiation." . [] oboInOwl:hasDbXref "PMID:28553007" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4040006 ; owl:annotatedTarget "A chromatophore that is part of the dermis." . [] oboInOwl:hasDbXref "PMID:32999462", "PMID:34727523" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042001 ; owl:annotatedTarget "A GABAergic interneuron that has its soma located in the striatum and that has an enriched expression of the genes TAC3 and LHX6." . [] oboInOwl:hasDbXref "PMID:34727523" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4042001 ; owl:annotatedTarget "TAC3 interneuron" . [] oboInOwl:hasDbXref "PMID:34727523" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042002 ; owl:annotatedTarget "A nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron that co-expresses TAC3 and the DRD1 receptor." . [] oboInOwl:hasDbXref "PMID:34727523" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042002 ; owl:annotatedTarget "D1Sh TAC3 archetype" . [] oboInOwl:hasDbXref "PMID:34727523" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042002 ; owl:annotatedTarget "TAC3-positive D1Sh-MSN" . [] oboInOwl:hasDbXref "PMID:34727523" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042002 ; owl:annotatedTarget "TAC3-positive MSN" . [] oboInOwl:hasDbXref "PMID:34727523" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042002 ; owl:annotatedTarget "A TAC3-positive medium spiny neuron has its soma in a cluster in the medial shell region of the nucleus accumbens. In Rhesus Macaque, this medium spiny neuron has an enriched expression of the genes MPPED1, HPCAL1, MEIS3." . [] oboInOwl:hasDbXref "PMID:37232741", "PMID:37626977" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042003 ; owl:annotatedTarget "A central nervous system macrophage that is part of a choroid plexus, a meninx and a perivascular space. A border associated macrophage interacts with various components of the CNS vasculature and meninges, it participates in immune surveillance and in the regulation of the blood brain barrier." . [] oboInOwl:hasDbXref "PMID:36945367" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042003 ; owl:annotatedTarget "BAM" . [] oboInOwl:hasDbXref "PMID:33556248" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042003 ; owl:annotatedTarget "CAM" . [] oboInOwl:hasDbXref "PMID:37232741" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042003 ; owl:annotatedTarget "CNS-associated macrophage" . [] oboInOwl:hasDbXref "PMID:29426702", "PMID:37232741" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042003 ; owl:annotatedTarget "In humans, a border associate macrophage expresses CD45 and CD11B. This cell is also known to have the following molecular signature: CD206, CD38, LYVE1, CD163, CD169." . [] oboInOwl:hasDbXref "PMID:31061494", "PMID:37232741" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042004 ; owl:annotatedTarget "A choroid plexus macrophage that is part of the apical surface of some choroid plexus epithelium. This macrophage has a star-like shaped body." . [] oboInOwl:hasDbXref "PMID:31433571" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4042004 ; owl:annotatedTarget "Kolmer’s cell" . [] oboInOwl:hasDbXref "PMID:38347231" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042004 ; owl:annotatedTarget "cpepiMΦ" . [] oboInOwl:hasDbXref "PMID:38347231" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042004 ; owl:annotatedTarget "epiplexus cpMΦ" . [] oboInOwl:hasDbXref "PMID:38347231" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042005 ; owl:annotatedTarget "A choroid plexus macrophage that is part of a choroid plexus stroma." . [] oboInOwl:hasDbXref "PMID:37626977" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042005 ; owl:annotatedTarget "cpstMΦ" . [] oboInOwl:hasDbXref "PMID:37232741", "PMID:38347231" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042005 ; owl:annotatedTarget "stromal cpMΦ" . [] oboInOwl:hasDbXref "PMID:31061494" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042006 ; owl:annotatedTarget "A border associated macrophage which is part of a dura matter. This macrophage phagocytoses intruding pathogens and foreign molecules detected in the bloodstream or in the cerebrospinal fluid. This cell has an amoeboid body with dynamic protrusions in homeostasis." . [] oboInOwl:hasDbXref "PMID:37232741" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042006 ; owl:annotatedTarget "dmMΦ" . [] oboInOwl:hasDbXref "PMID:19279265", "PMID:25904839", "PMID:34616062", "PMID:37139179", "PMID:37824655" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042007 ; owl:annotatedTarget "An astrocyte with highly branched protrusions, found in neocortex layers 2-6. It is involved with the formation and elimination of synapses, glutamate clearance, modulation of synaptic functions and regulation of blood flow in response to synaptic activity." . [] oboInOwl:hasDbXref "PMID:19279265", "PMID:20012068" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042007 ; owl:annotatedTarget "This astrocyte extends its branches to several hundred of dendrites to multiple neurons to envelope 100,000 or more synapses. In humans, a protoplasmic astrocyte has an average diameter of 142 µm, and its diameter ranges between 100 and 400 µm. In rodents the average diameter of a protoplasmic astrocites is 56 µm." . [] oboInOwl:hasDbXref "PMID:19279265", "PMID:22144298", "PMID:28280934", "PMID:31435019", "PMID:34616062", "PMID:37824655" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042008 ; owl:annotatedTarget "A cell type located in the first layer of the neocortex with radial protrusions extending transversely into the deeper cortex layers, herby facilitating communication across neurons, astrocytes, capillaries, meninges and cerebrospinal fluid through contact with neurons, pia mater and capillaries." . [] oboInOwl:hasDbXref "PMID:28280934" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042008 ; owl:annotatedTarget "In humans, a fibrous astrocyte diameter is circa 182 µm. In rodents, a fibrous astrocyte diameter is circa 85 µm." . [] oboInOwl:hasDbXref "PMID:19279265", "PMID:30552685", "PMID:31435019", "PMID:32930323", "PMID:34616062", "PMID:37824655" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042009 ; owl:annotatedTarget "An astrocyte type that presents radial protrusions across the layers of a cortex. The soma of this astrocyte is part of the first layer of a neocortex. This astrocyte extents its protrusions transversally to the deeper layers of a cortex and it creates contact with neurons, the pia matter and capillaries. This astrocyte is involved in facilitating the communication across neurons, astrocytes, capillaries, meninges and the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:30552685" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042009 ; owl:annotatedTarget "ILA" . [] oboInOwl:hasDbXref "PMID:32930323", "PMID:37139179" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042010 ; owl:annotatedTarget "An interlaminar astrocyte whose soma is part of the first layer of a neocortex and is in contact with a pia surface." . [] oboInOwl:hasDbXref "PMID:32930323", "PMID:37139179" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042011 ; owl:annotatedTarget "An interlaminar astrocyte type whose soma is part of the upper first layer of the neocortex and its processes extend to a pia surface." . [] oboInOwl:hasDbXref "PMID:29311847", "PMID:32108571" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042012 ; owl:annotatedTarget "An L2 intratelencephalic projecting glutamatergic neuron with a soma on the L1-L2 border. This neuron type has small apical dendrites projecting to L1." . [] oboInOwl:hasDbXref "PMID:32108571" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4042012 ; owl:annotatedTarget "layer 2 marginal neuron" . [] oboInOwl:hasDbXref "PMID:29311847", "PMID:32108571" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042012 ; owl:annotatedTarget "L2MN" . [] oboInOwl:hasDbXref "PMID:34004146", "PMID:36007006", "PMID:37824655", "PMID:37824669", "https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042013 ; owl:annotatedTarget "A transcriptomically distinct lamp5 GABAergic cortical interneuron located in the cerebral cortex that expresses Lamp5 and Lhx6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', Lamp5 Lhx6." . [] oboInOwl:hasDbXref "PMID:36007006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4042013 ; owl:annotatedTarget "Ivy cell" . [] oboInOwl:hasDbXref "PMID:30382198" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4042013 ; owl:annotatedTarget "Lamp5-Lhx6 type" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042013 ; owl:annotatedTarget "The marker set CHST9, LAMP5 can identify the Human cell type Lamp5 Lhx6 neuron in the neocortex with a confidence of 0.821678322 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "PMID:35418660" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042014 ; owl:annotatedTarget "A VIP GABAergic cortical interneuron with a soma located in L1-3 of some neocortex in Mmus. This neuron has a multipolar morphology with spiny dendrites concentrating on L1 of the cortex, and has a burst firing electrophysiological signature with highly dynamic dendritic spines." . [] oboInOwl:hasDbXref "PMID:35418660" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4042014 ; owl:annotatedTarget "superficial VIP-positive spiny neuron" . [] oboInOwl:hasDbXref "PMID:35418660" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042014 ; owl:annotatedTarget "multipolar VIP neuron" . [] oboInOwl:hasDbXref "PMID:30382198", "PMID:31754098", "PMID:32027647", "PMID:33301603" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042015 ; owl:annotatedTarget "A VIP GABAergic cortical interneuron expressing vasoactive intestinal polypeptide and choline acetyltransferase in the Mmus neocortex. This interneuron releases both γ-aminobutyric acid and acetylcholine." . [] oboInOwl:hasDbXref "PMID:33301603" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4042015 ; owl:annotatedTarget "VIP+/ChAT+ interneuron" . [] oboInOwl:hasDbXref "PMID:32027647" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4042015 ; owl:annotatedTarget "VIP/ChAT interneuron" . [] oboInOwl:hasDbXref "PMID:32027647" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042015 ; owl:annotatedTarget "VChI" . [] oboInOwl:hasDbXref "PMID:33301603" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042015 ; owl:annotatedTarget "VIP+/ChAT+ cell" . [] oboInOwl:hasDbXref "PMID:30382198", "PMID:32027647", "PMID:33301603" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042015 ; owl:annotatedTarget "Work in the mouse barrel cortex and somatosensory cortex shows that a VIP-ChAT interneuron is predominantely located in L2/3 and more rarely in the deeper layers of the cortex (Dudai et al., 2021; Dudai et al., 2020). This neuronal type could be transcriptomically distinct as transcriptomic studies have identified VIP neurons expressing ChAT in a whole brain mouse transcriptomic study (Tasic et al., 2018)." . [] oboInOwl:hasDbXref "PMID:37291214" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042016 ; owl:annotatedTarget "A serous secreting cell that is part of a submucosal gland in the nasal cavity respiratory epithelium." . [] oboInOwl:hasDbXref "PMID:11005715" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042016 ; owl:annotatedTarget "nasal mucous secretory cell" . [] oboInOwl:hasDbXref "PMID:16344112", "PMID:26578855", "wikipedia:Tanycyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042017 ; owl:annotatedTarget "The dorsal-most tanycyte type of the third venticle. These cells projects into the ventromedial or dorsomedial nucleus of the hypothalamus. This type of tanycyte extends its protrusions close to parenchymal neurons without contacting blood vessels. It expresses the glial marker S-100β." . [] oboInOwl:hasDbXref "PMID:29351662" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042017 ; owl:annotatedTarget "DMH tanycyte" . [] oboInOwl:hasDbXref "PMID:29351662" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042017 ; owl:annotatedTarget "VMH tanycyte" . [] oboInOwl:hasDbXref "PMID:26578855" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042017 ; owl:annotatedTarget "In rodents, a1 tanycytes are known to express DARPP-32, GPR50, NA Vimentin, Connexin 43, GLT-1, GLUT1(+) (Goodman and Hajihosseini 2015; Prevot et al., 2018)." . [] terms:license ; oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4042017 ; owl:annotatedTarget . [] dc:license ; oboInOwl:hasDbXref ; a owl:Axiom ; rdfs:comment "α1 tanycytes are the most dorsally located subtype, followed by α2 tanycytes, then β1 tanycytes, and finally β2 tanycytes which occupy the ventricular floor. 3V, third ventricle; Arc, arcuate nucleus; DMH, dorsomedial hypothalamic nucleus; VMH, ventromedial hypothalamic nucleus." ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4042017 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "PMID:16344112", "PMID:26578855", "PMID:29351662", "wikipedia:Tanycyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042018 ; owl:annotatedTarget "Tanycyte of the third ventricle, located immediately ventral to alpha-1 tanycytes. These cells project to the ventromedial and arcuate nuclei of the hypothalamus and express the glial marker S-100β." . [] oboInOwl:hasDbXref "PMID:29351662" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042018 ; owl:annotatedTarget "dmARH tanycyte" . [] oboInOwl:hasDbXref "PMID:26578855" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042018 ; owl:annotatedTarget "In rodents, this type of tanycyte is more developmentally advanced than alpha1 tanycytes, shows a high neurogenic competence and expresses the following markers DARPP-32, Vimentin, GPR50, Connexin-43, GLT-1, GLUT1(+) (Goodman and Hajihosseini 2015; Prevot et al., 2018)" . [] terms:license ; oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4042018 ; owl:annotatedTarget . [] dc:license ; oboInOwl:hasDbXref ; a owl:Axiom ; rdfs:comment "α1 tanycytes are the most dorsally located subtype, followed by α2 tanycytes, then β1 tanycytes, and finally β2 tanycytes which occupy the ventricular floor. 3V, third ventricle; Arc, arcuate nucleus; DMH, dorsomedial hypothalamic nucleus; VMH, ventromedial hypothalamic nucleus." ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4042018 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "PMID:16344112", "PMID:26578855", "PMID:29351662", "Wikipedia:Tanycyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042019 ; owl:annotatedTarget "A type of tanycyte located in ventral part of the lateral wall of the third ventricle and in the lateral infundibular recess of the brain. This tanycyte has an elongated morphology with multiple microvilli extending into the median eminence. This type of tanycyte expresses FGF receptors 1 and 2, is in contact with GnRH neurons, and is involved in the release of gonadotropin-releasing hormone (GnRH)." . [] oboInOwl:hasDbXref "PMID:29351662" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042019 ; owl:annotatedTarget "vmARH tanycyte" . [] terms:license ; oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4042019 ; owl:annotatedTarget . [] dc:license ; oboInOwl:hasDbXref ; a owl:Axiom ; rdfs:comment "α1 tanycytes are the most dorsally located subtype, followed by α2 tanycytes, then β1 tanycytes, and finally β2 tanycytes which occupy the ventricular floor. 3V, third ventricle; Arc, arcuate nucleus; DMH, dorsomedial hypothalamic nucleus; VMH, ventromedial hypothalamic nucleus." ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4042019 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "PMID:16344112", "PMID:26578855", "PMID:29351662", "wikipedia:Tanycyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042020 ; owl:annotatedTarget "A type of tanycyte located in the floor of third ventricle and the infindibular recess. This tanycyte has an elongated morphology with multiple microvilli extending medially and ventrally to the median eminence, contacting the pial surface and blood vessels. This type of tanycyte expresses FGF receptors 1 and 2, is in contact with GnRH neurons, and is involved in the release of gonadotropin-releasing hormone (GnRH)." . [] oboInOwl:hasDbXref "PMID:29351662" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042020 ; owl:annotatedTarget "ME tanycyte" . [] terms:license ; oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4042020 ; owl:annotatedTarget . [] dc:license ; oboInOwl:hasDbXref ; a owl:Axiom ; rdfs:comment "α1 tanycytes are the most dorsally located subtype, followed by α2 tanycytes, then β1 tanycytes, and finally β2 tanycytes which occupy the ventricular floor. 3V, third ventricle; Arc, arcuate nucleus; DMH, dorsomedial hypothalamic nucleus; VMH, ventromedial hypothalamic nucleus." ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4042020 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "PMID:10467245" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042021 ; owl:annotatedTarget "A progenitor cell of the central nervous system that differentiates exclusively onto neurons. This progenitor cell is found in a hippocampus subventricular zone, developing cortex and spinal cord of the central nervous system." . [] oboInOwl:SynonymTypeProperty obo:OMO_0003000 ; oboInOwl:hasDbXref "PMID:12429182" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042021 ; owl:annotatedTarget "NRP" . [] oboInOwl:hasDbXref "PMID:12429182", "PMID:9354325" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042021 ; owl:annotatedTarget "In vitro cultures of embryonic mouse neural tubes show that neuronal-restricted precursors (NRPs) are derived from multipotent neuroepithelial cells to give rise to neurons. This progression suggests a linear relationship between multipotent progenitors and neuronal-restricted differentiation. (Mayer-Proschel et al., 1997). In the spinal cord of rats, neural-restricted precursor cells give rise cholinergic, GABAergic, glutametergic neurons (Cao and Howard et al., 2002)." . [] oboInOwl:hasDbXref "PMID:15531362", "PMID:33052610" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042022 ; owl:annotatedTarget "A progenitor cell of the central nervous system that differentiates exclusively onto astrocytes. This progenitor cell expresses CD44 and S100 calcium-binding protein B." . [] oboInOwl:SynonymTypeProperty obo:OMO_0003000 ; oboInOwl:hasDbXref "PMID:33052610" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042022 ; owl:annotatedTarget "ARP" . [] oboInOwl:hasDbXref "PMID:33052610" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042022 ; owl:annotatedTarget "astrocyte precursor cell" . [] oboInOwl:hasDbXref "PMID:33052610" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042022 ; owl:annotatedTarget "In vitro, this progenitor cell can differentiate from glial-restricted precursor cells." . [] oboInOwl:hasDbXref "PMID:30134177", "PMID:37292997" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042023 ; owl:annotatedTarget "A GABAergic interneuron expressing PTHLH and PVALB that has its soma in a striatum. This GABAergic interneuron type presents a spatial expression gradient of PVALB in the mouse striatum." . [] oboInOwl:hasDbXref "PMID:37292997" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042023 ; owl:annotatedTarget "PTHLH/PVALB cell" . [] oboInOwl:hasDbXref "PMID:37292997" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042023 ; owl:annotatedTarget "PTHLH +/PVALB+ interneuron" . [] oboInOwl:hasDbXref "PMID:37292997" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042023 ; owl:annotatedTarget "According to spatial transcriptomic data in the human striatum, pthlh-expressing interneurons are one of the most abundant population of interneurons in the striatum (Leonardo D. Garma, et al., 2024)." . [] oboInOwl:hasDbXref "PMID:30134177" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042024 ; owl:annotatedTarget "A pthlh-expressing interneuron that expresses MOXD1 and has its soma in a striatum." . [] oboInOwl:hasDbXref "PMID:32826893", "PMID:35308118" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042025 ; owl:annotatedTarget "A midbrain dopaminergic neuron that has its soma located in a substantia nigra. This dopaminergic neuron type is highly metabolically active and it is involved in the regulation of movement, cognition, motivation and reward. Neurodegeneration of this dopaminergic neuronal type causes loss in fine motor control in Parkinson's Disease." . [] oboInOwl:hasDbXref "PMID:35308118" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_4042025 ; owl:annotatedTarget "SNpc dopaminergic neuron" . [] oboInOwl:hasDbXref "PMID:36148148" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042026 ; owl:annotatedTarget "A GABAergic interneuron that has its soma in the anterior section of the substantia nigra pars reticulata. This GABAergic interneuron is characterized by the expression of Six3 and Foxp1 and it develops from Nkx6-2 expressing neuronal progenitors in the ventrolateral midbrain-diencephalon region." . [] oboInOwl:hasDbXref "PMID:36148148" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042026 ; owl:annotatedTarget "aSNpr" . [] oboInOwl:hasDbXref "PMID:36148148" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042027 ; owl:annotatedTarget "A GABAergic interneuron that has its soma in the posterior section of the substantia nigra pars reticulata. This GABAergic interneuron is characterised by the expression of the transcription factors Pax5, Ctip2 and Pou6f2 and it develops from the ventrolateral r1 neuroepithelium expresing NKX61." . [] oboInOwl:hasDbXref "PMID:36148148" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042027 ; owl:annotatedTarget "pSNpr" . [] oboInOwl:hasDbXref "PMID:31096632", "PMID:32116519", "PMID:37833544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042028 ; owl:annotatedTarget "A neuron in the central nervous system that is not committed to a differentiated fate, has not been newly derived from neurogenesis, and does not integrate into any circuit." . [] oboInOwl:hasDbXref "PMID:32116519" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042028 ; owl:annotatedTarget "IN" . [] oboInOwl:hasDbXref "PMID:32116519" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042028 ; owl:annotatedTarget "It is hypothesised that immature neurons can be utilised as a neurogenic reserve and that they can be involved in circuit plasticity." . [] oboInOwl:hasDbXref "PMID:37833544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042029 ; owl:annotatedTarget "An immature neuron of a cerebral cortex. This neuron develops prenatally and remains in an immature state throughout the lifespan of the organism." . [] oboInOwl:hasDbXref "PMID:37833544" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042029 ; owl:annotatedTarget "cIN" . [] oboInOwl:hasDbXref "PMID:35578131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042030 ; owl:annotatedTarget "A GABAergic interneuron located in the Purkinje layer of the cerebellar cortex. This GABAergic interneuron type has a distinct morphology, it presents a small cell soma near the Purkinje cell layer (PCL), dendrites that extend to the surface of the molecular layer, and beaded axons that make local synapses contacts within the molecular layer. A candelabrum cell is excited by mossy fibers and granule cells but inhibited by Purkinje cells, and it inhibits molecular layer interneurons, which leads to the disinhibition of Purkinje cells." . [] oboInOwl:hasDbXref "PMID:35578131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4042030 ; owl:annotatedTarget "candelabrum interneuron" . [] oboInOwl:hasDbXref "PMID:35578131" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042030 ; owl:annotatedTarget "CC" . [] oboInOwl:hasDbXref "PMID:35578131" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042030 ; owl:annotatedTarget "Candelabrum cells are the most abundant interneurons in the Purkinje cell layer and are present in all cerebellar lobules." . [] dc:license ; oboInOwl:hasDbXref "doi:10.3389/fnins.2020.00293" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4042030 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "PMID:30747918", "PMID:35301426", "PMID:35615276", "PMID:35662200" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042031 ; owl:annotatedTarget "An oligodendrocyte of the central nervous system that exhibits immune properties such as self-presentation and non-self antigen presentation to T cells, phagocytosis of debris, and cytokine and chemokine production. Immune oligodendroglia is immunoreactive during inflammation, neurodegenerative disorders, chronic stress and major depressive disorder." . [] oboInOwl:hasDbXref "PMID:35615276" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4042031 ; owl:annotatedTarget "immune oligodendrocyte" . [] oboInOwl:hasDbXref "PMID:35301426" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042031 ; owl:annotatedTarget "Im-OL" . [] oboInOwl:hasDbXref "PMID:35615276" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042031 ; owl:annotatedTarget "ImOL" . [] oboInOwl:hasDbXref "PMID:30747918" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042031 ; owl:annotatedTarget "ImOLG" . [] oboInOwl:hasDbXref "PMID:30747918" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042031 ; owl:annotatedTarget "imOLG" . [] oboInOwl:hasDbXref "PMID:35301426", "PMID:35615276", "PMID:37057892" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042031 ; owl:annotatedTarget "During inflammation, immuno oligodendroglia express MHC II to interact with immune cells in mouse models (Harrington et al., 2023; Madeira et al., 2022). In a mouse model of major depressive disorder and chronic stress, immuno oligodendroglia were associated with prefrontal cortex hypomyelination (Kokkosis et al., 2022)." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000451 ; owl:annotatedTarget "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." . [] oboInOwl:hasDbXref "PMID:37824655", "https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042032 ; owl:annotatedTarget "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses the transcript PAX6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters PAX6." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042032 ; owl:annotatedTarget "The marker set RELN, HCRTR2 can identify the Human cell type PAX6 GABAergic cortical interneuron in the neocortex with a confidence of 0.724125093 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "PMID:25870542", "PMID:28192062" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042033 ; owl:annotatedTarget "A neuron of the central nervous system that expresses POMC and synthesizes the POMC precursor polypeptide. This neuron type is located in the arcuate nucleus of the hypothalamus and in the nucleus tractus solitarius of the brainstem. The pro-opiomelanocortin neuron is part of the central melanocortin system and it is involved in regulating energy homeostasis, metabolism, and appetite. This neuronal type responds to hormonal signals such as levels of leptin and insulin, and its activation results in the release of α-melanocyte-stimulating hormone (α-MSH), which acts on melanocortin receptors to suppress food intake and increase energy expenditure." . [] oboInOwl:hasDbXref "PMID:34002087" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042033 ; owl:annotatedTarget "POMC neuron" . [] oboInOwl:hasDbXref "PMID:34002087" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042033 ; owl:annotatedTarget "POMC-expressing neuron" . [] oboInOwl:hasDbXref "PMID:28192062", "PMID:33633406" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042033 ; owl:annotatedTarget "Pro-opiomelanocortin neurons have a diverse projection pattern. The neurons in the rostral arcuate nucleus project to autonomic areas, caudal arcuate POMC neurons project mainly to hypothalamic areas (Toda et al., 2017). Dysregulation of pro-opiomelanocortin neurons is associated with obesity and metabolic disorders (Quarta et al., 2020)." . [] oboInOwl:hasDbXref "PMID:34061020" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042034 ; owl:annotatedTarget "An interneuron neuron characterized by the expression of calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide. This neuron type is involved in nociception and pain modulation by facilitating the transmission of nociceptive signals from peripheral sensory nerve endings to central nervous system structures. This neuron type is found in the dorsal root ganglia (DRG) and trigeminal ganglion, and the spinal cord dorsal horn." . [] oboInOwl:hasDbXref "PMID:34061020" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4042034 ; owl:annotatedTarget "Calcitonin gene-related peptide neuron" . [] oboInOwl:hasDbXref "PMID:34061020" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042034 ; owl:annotatedTarget "CGRP-expressing interneuron" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000451 ; owl:annotatedTarget "ZFA:0009209" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:34061020" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042034 ; owl:annotatedTarget "CGRP-positive neuron" . [] oboInOwl:hasDbXref "PMID:30742002", "PMID:33075461", "PMID:34616064", "PMID:38692278" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042035 ; owl:annotatedTarget "A type of cerebellar inhibitory GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell type inhibits Purkinje cells and other molecular layer interneurons. This interneuron plays a crucial role in regulating cerebellar output through feedforward inhibition and is characterized by its fast-spiking properties." . [] oboInOwl:hasDbXref "PMID:33075461" ; oboInOwl:hasRelatedSynonym obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042035 ; owl:annotatedTarget "MLI" . [] oboInOwl:hasDbXref "PMID:30284033", "PMID:38020069", "PMID:39035036" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042036 ; owl:annotatedTarget "A neuron of the central nervous system with its soma primarily located in the lateral hypothalamic area and surrounding regions, including the zona incerta. This neuron type expresses melanin-concentrating hormone and is involved in regulating various physiological processes, including sleep, feeding behavior, and energy homeostasis." . [] oboInOwl:hasDbXref "PMID:30284033" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042036 ; owl:annotatedTarget "MCH neuron" . [] oboInOwl:hasDbXref "PMID:38020069" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042036 ; owl:annotatedTarget "Nearly all melanin-concentrating hormone neurons express the glutamate transporter VGlut2, however a small subset of them expresses the machinery for GABA release and neurotransmission." . [] oboInOwl:hasDbXref "PMID:30131490", "PMID:30467465", "PMID:33742131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042037 ; owl:annotatedTarget "A interneuron of the striatum expressing gamma-aminobutyric acid and somatostatin. This interneuron has a fusiform soma with a diameter between 9 - 25 µm, it has a long axon up to the length of 1mm. This neuron type displays a low threshold Ca2+ spike (LTS), a high input resistance, and the expression of long-lasting plateau potentials following depolarization from rest." . [] oboInOwl:hasDbXref "PMID:30131490" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4042037 ; owl:annotatedTarget "SOM cell" . [] oboInOwl:hasDbXref "PMID:33742131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042037 ; owl:annotatedTarget "striatal SST+ IN" . [] oboInOwl:hasDbXref "PMID:30467465", "PMID:33742131" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042037 ; owl:annotatedTarget "Some striatal SST GABAergic neurons can co-release glutamate and generate excitation-inhibition responses in postsynaptic neurons. This interneuron type has the least dense dendritic branches in the striatum. In the dorsomedial striatum these neurons regulate the activity of striatal projection neurons." . [] oboInOwl:hasDbXref "PMID:35431796", "PMID:3746410" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042038 ; owl:annotatedTarget "A type of primary motor neuron situated in the rostral region of the spinal cord. RoP neurons extend their axons to innervate the ventral trunk musculature." . [] oboInOwl:hasDbXref "PMID:3746410" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042038 ; owl:annotatedTarget "RoP" . [] oboInOwl:hasDbXref "PMID:12593982", "PMID:12637172", "PMID:20130169", "https://www.ncbi.nlm.nih.gov/books/NBK98190/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042039 ; owl:annotatedTarget "A neuron of the central nervous system that develops from a caudal ganglionic eminence." . [] oboInOwl:hasDbXref "PMID:12593982", "PMID:12637172", "PMID:20130169", "https://www.ncbi.nlm.nih.gov/books/NBK98190/" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042039 ; owl:annotatedTarget "Neurons derived from the caudal ganglionic eminence consist mostly of neurons populating the cortical layers of the brain and some subcortical areas such as the globus pallidus, the striatus and the hippocampus. Amongst neurons derived from the caudal ganglionic eminence there are cortical GABAergic neurons such as Pax6, Lamp5, VIP, sncg, GABAergic; in the hippocampus, mossy fibers, pyramidal neurons, granule neurons and interneurons; in the striatum and globus pallidus, medium spiny projection neurons." . [] oboInOwl:hasDbXref "DOI:10.1016/j.jocn.2021.05.056", "PMID:11307040", "PMID:16276355" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042040 ; owl:annotatedTarget "A glutametergic neuron with its soma located in a basal ganglia. This neuron type is involved in motor control, decision making and learning." . [] oboInOwl:hasDbXref "PMID:22498715", "PMID:30498197", "PMID:33785138" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4042040 ; owl:annotatedTarget "The glutametergic neurons in the basal ganglia are part of a series of different circuits such as the corticolstriatal circuit, which is involved in regulating voluntary movements. The subthalamic nucleus circuit, which is involved in modulating the output of the basal ganglia, particularly in controlling movement initiation and inhibition. The thalamocortical loop, which is involved in refining motor movements and integrating sensory information with motor commanding." . [] oboInOwl:hasDbXref "PMID:35431796", "PMID:3746410" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4042041 ; owl:annotatedTarget "A type of primary motor neuron located in the middle region of the spinal cord. This primary motor neuron type is characterized by their distinct axonal pathways that innervate the middle trunk muscles." . [] oboInOwl:hasDbXref "PMID:3746410" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4042041 ; owl:annotatedTarget "MiP" . [] oboInOwl:hasDbXref "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047001 ; owl:annotatedTarget "A(n) stromal cell that is cycling." . [] oboInOwl:hasDbXref "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047001 ; owl:annotatedTarget "proliferating stromal cell" . [] oboInOwl:hasDbXref "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047002 ; owl:annotatedTarget "A(n) glial cell that is cycling." . [] oboInOwl:hasDbXref "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047002 ; owl:annotatedTarget "proliferating glial cell" . [] oboInOwl:hasDbXref "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047003 ; owl:annotatedTarget "A(n) plasma cell that is cycling." . [] oboInOwl:hasDbXref "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047003 ; owl:annotatedTarget "proliferating plasma cell" . ( ) . [] oboInOwl:hasDbXref "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047004 ; owl:annotatedTarget "A(n) type EC enteroendocrine cell that is cycling." . [] oboInOwl:hasDbXref "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047004 ; owl:annotatedTarget "proliferating type EC enteroendocrine cell" . [] oboInOwl:hasDbXref "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047005 ; owl:annotatedTarget "A(n) neuroblast (sensu Vertebrata) that is cycling." . [] oboInOwl:hasDbXref "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047005 ; owl:annotatedTarget "proliferating neuroblast (sensu Vertebrata)" . [] oboInOwl:hasDbXref "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047006 ; owl:annotatedTarget "An endothelial cell that lines an artery in the fetal circulatory system." . [] oboInOwl:hasDbXref "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047006 ; owl:annotatedTarget "endothelial cell of fetal artery" . [] oboInOwl:hasDbXref "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047006 ; owl:annotatedTarget "fetal arterial EC" . [] oboInOwl:hasDbXref "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047006 ; owl:annotatedTarget "fetal artery EC" . [] oboInOwl:hasDbXref "PMID:21839917", "PMID:28564607", "PMID:32466671", "PMID:34497389", "PMID:36685855" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047007 ; owl:annotatedTarget "A pericyte that is in an early stage of development, found in newly forming or remodeling blood vessels. An immature pericyte is characterized by it's mesenchymal stem cell-like properties and high proliferative capacity, which allows it to differentiate into various types of pericytes and contribute to the structural and functional maturation of the vasculature. Immature pericytes are stellate in new vessels and elongated with less protrusions in remodeling vessels." . [] oboInOwl:hasDbXref "PMID:28564607" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4047007 ; owl:annotatedTarget "imPCs" . [] oboInOwl:hasDbXref "PMID:28564607" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4047007 ; owl:annotatedTarget "immature PCs" . [] oboInOwl:hasDbXref "doi:10.1101/2021.04.07.438755" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047011 ; owl:annotatedTarget "An endothelial cell that lines the veins in the fetal circulatory system." . [] oboInOwl:hasDbXref "doi:10.1101/2021.04.07.438755" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047011 ; owl:annotatedTarget "fetal venous endothelial cell" . [] oboInOwl:hasDbXref "doi:10.1101/2021.04.07.438755" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4047011 ; owl:annotatedTarget "fetal vein EC" . [] oboInOwl:hasDbXref "doi:10.1101/2021.04.07.438755" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4047011 ; owl:annotatedTarget "fetal venous EC" . [] oboInOwl:hasDbXref "PMID:24853910", "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047012 ; owl:annotatedTarget "A specialized pericyte that actively participates in the formation of new blood vessels during angiogenesis by undergoing phenotypic changes, increasing proliferation, and interacting closely with endothelial cells." . [] oboInOwl:hasDbXref "PMID:20683682", "PMID:33195268", "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047017 ; owl:annotatedTarget "A transit amplifying cell of the gut epithelium, located in the wall of the intestinal crypt, just above intestinal stem cells from which they derive. These are rapidly dividing cells, capable of multiple rounds of division before differentiating into the various cell types of the gut epithelium (enterocyte, goblet, eneterodendocrine, paneth cells)." . [] oboInOwl:hasDbXref "PMID:24813615" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4047017 ; owl:annotatedTarget "transit-amplifying cell" . [] oboInOwl:hasDbXref "PMID:20683682" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4047017 ; owl:annotatedTarget "TA cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000453 ; owl:annotatedTarget obo:CL_0000990 . [] oboInOwl:hasDbXref "PMID:28049136", "PMID:36060223" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047018 ; owl:annotatedTarget "An enterocyte that is part of the colon, in the early stages of differentiation, located in the intestinal crypt-villus axis." . [] oboInOwl:hasDbXref "doi:10.1101/2021.01.13.426602" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047018 ; owl:annotatedTarget "early enterocyte of colon" . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GO_REF:0000031", "ISBN:0721601464", "ISBN:0781735149", "PMCID:PMC2346585", "PMID:17850486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000453 ; owl:annotatedTarget "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." . [] oboInOwl:hasDbXref "PMID:20683682", "PMID:35235783" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047019 ; owl:annotatedTarget "An enterocyte in the early stages of development, located above the transit-amplifying cell zone in the intestinal crypt-villus axis." . [] oboInOwl:hasDbXref "PMID:21252048", "PMID:36032088" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047023 ; owl:annotatedTarget "A fibroblast located in the lamina propria of the intestinal mucosa. This cell expresses PDGFRα and CD81 and is negative for α-smooth muscle actin (α-SMA). This cell is predominantly located in the small intestine adjacent to myofibroblasts surrounding the crypts. It is capable of synthesizing extracellular matrix components and structural proteins such as collagen and elastin." . [] oboInOwl:hasDbXref "PMID:30270042" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4047023 ; owl:annotatedTarget "S1 fibroblast" . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047025 ; owl:annotatedTarget "Any type G enteroendocrine cell that is part of some epithelium of stomach." . [] oboInOwl:hasDbXref "PMID:17893694", "PMID:35406678" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047029 ; owl:annotatedTarget "An endothelial cell forming the walls of capillaries immediately downstream from arterioles, facilitating the exchange of substances between blood and interstitial fluid. This cell is characterized by a small diameter and may be continuous, fenestrated, or sinusoidal, depending on their location and function. This cell plays a crucial role in tissue oxygenation, nutrient delivery, and maintaining homeostasis within the microvascular network." . [] oboInOwl:hasDbXref "DOI:10.1038/s41467-022-33324-7", "PMID:23620236" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047030 ; owl:annotatedTarget "A specialized endothelial cell located in the transition zone between capillaries and small venules in the microvascular system. It exhibits characteristics of both capillary and venous cells, expressing markers from both types. This cell plays a role in regulating blood flow and substance exchange between blood and tissues." . [] oboInOwl:hasDbXref "DOI:10.1038/s41467-022-33324-7" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047030 ; owl:annotatedTarget "Cap-Venous endothelial cell" . [] oboInOwl:hasDbXref "DOI:10.3389/fncel.2019.00282" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047032 ; owl:annotatedTarget "A specialized pericyte located within the basement membrane of a blood capillary. This cell is characterized by its ability to produce and release a variety of bioactive molecules, collectively known as the pericyte secretome, including cytokines and regulators of angiogenesis." . [] oboInOwl:hasDbXref "PMID:21443757", "PMID:33630273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047034 ; owl:annotatedTarget "A smooth muscle cell that is part of the muscularis externa of the stomach wall. It is characterized by its fusiform shape, involuntary control, and ability to generate slow, sustained contractions. This cell is organized in distinct layers and is essential for gastric motility and digestion." . [] oboInOwl:hasDbXref "PMID:21443757", "PMID:33630273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047035 ; owl:annotatedTarget "A specialized smooth muscle cell located in the outermost layer of the muscularis externa of the stomach wall. This cell is arranged longitudinally along the stomach's axis and is responsible for the contractions that facilitate food movement toward the pylorus." . [] oboInOwl:hasDbXref "PMID:11146428", "PMID:32424507" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047036 ; owl:annotatedTarget "A smooth muscle cell located in the middle layer of the muscularis externa of the stomach wall. This cell is arranged concentrically with the stomach's longitudinal axis, forming a continuous sheet of contractile tissue. It is fusiform in shape, containing actin and myosin filaments that enable contraction without striations. This cell contributes to the mechanical digestion and movement of food within the stomach through coordinated contractions, and plays a role in forming the pyloric sphincter in the pyloric region." . [] oboInOwl:hasDbXref "PMID:29493959" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047037 ; owl:annotatedTarget "A smooth muscle cell found in the innermost layer of the muscularis externa of the stomach wall. This cell forms a unique layer of smooth muscle fibers oriented obliquely to the stomach's longitudinal axis. It is responsible for aiding in the mixing and churning of gastric contents, contributing to mechanical digestion within the stomach." . [] oboInOwl:hasDbXref "DOI:10.1038/s41575-020-0271-2", "DOI:10.1038/s41575-021-00561-y", "PMID:32152479", "PMID:34170401" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047038 ; owl:annotatedTarget "A multipolar neuron in the myenteric plexus of the gastrointestinal tract, characterized by a small to medium-sized cell body and multiple short dendrites. This neuron exhibits fast excitatory postsynaptic potentials and can be classified into stubby, spiny and hairy subtypes based on dendritic morphology. (Brehmer, 2021)" . [] oboInOwl:hasDbXref "PMID:18221249", "PMID:27445346" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047040 ; owl:annotatedTarget "A smooth muscle cell that is found in the inner muscular layer of hollow organs. It is characterized by its spiral/helical arrangement around organ lumens. This cell is crucial for peristaltic movements in organs." . [] oboInOwl:hasDbXref "PMID:19906678", "PMID:21865647", "PMID:26964064", "PMID:28066889", "PMID:33731961" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047042 ; owl:annotatedTarget "An enteric glial cell located within the myenteric ganglia of the gastrointestinal tract. This cell has a small somata and has very short, irregularly branched processes that surround neuron cell bodies, giving it a protoplasmic-like appearance. It plays crucial roles in modulating myenteric neuron activity, regulating oxidative stress, and influencing neuroinflammation and neurogenesis." . [] oboInOwl:hasDbXref "PMID:33731961" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4047042 ; owl:annotatedTarget "type 1 MP" . [] oboInOwl:hasDbXref "DOI:10.3389/fncel.2023.1170309", "PMID:28487635", "PMID:33731961" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047043 ; owl:annotatedTarget "An enteric glial cell that is associated with neuron cell bodies within submucosal ganglia of the gastrointestinal tract. This cell is located in the submucosa, a layer of connective tissue beneath the intestinal mucosa. This cell plays a role in modulating secretomotor neuron activity and contributes to the regulation of digestive fluid secretion and absorption." . [] oboInOwl:hasDbXref "PMID:33731961" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4047043 ; owl:annotatedTarget "type I SMP" . [] oboInOwl:hasDbXref "DOI:10.1002/glia.22876", "PMID:33731961", "PMID:35111752" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047044 ; owl:annotatedTarget "An enteric glial cell that has an elongated, fibrous morphology with long processes that run parallel to nerve fibers connecting enteric myenteric ganglia. This cell is located in the interganglionic fiber tracts of the enteric nervous system." . [] oboInOwl:hasDbXref "PMID:35111752" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047044 ; owl:annotatedTarget "type II enteric glia" . [] oboInOwl:hasDbXref "PMID:25161129", "PMID:33731961", "PMID:37153631", "PMID:38957473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047045 ; owl:annotatedTarget "An enteric glial cell located in the lamina propria of the intestinal mucosa. This cell plays important roles in maintaining gut barrier function, regulating intestinal homeostasis, and mediating interactions between the enteric nervous system and the immune system." . [] oboInOwl:hasDbXref "DOI:10.1016/j.celrep.2023.112194", "PMID:29927320", "PMID:33731961", "PMID:35111752" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047047 ; owl:annotatedTarget "An enteric glial cell located within the ganglia of the enteric nervous system. This cell is characterized by it’s small somata and short, irregularly branched processes that surround neuronal cell bodies in the myenteric and submucosal ganglia. This cell plays important roles in modulating neuronal activity and neurogenesis in the gastrointestinal tract." . [] oboInOwl:hasDbXref "PMID:33731961" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047047 ; owl:annotatedTarget "intraganglionic glia" . [] oboInOwl:hasDbXref "PMID:35111752" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047047 ; owl:annotatedTarget "type I enteric glia" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12438093" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000454 ; owl:annotatedTarget "A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types." . [] oboInOwl:hasDbXref "PMID:33731961", "PMID:34401661" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047048 ; owl:annotatedTarget "An enteric glial cell characterized by a small central soma that extends long, thin, bipolar projections. This cell is primarily located along small nerve fibers within the muscle layers of the gastrointestinal tract and is known for its unbranching processes that closely follow these nerve fibers in the muscularis." . [] oboInOwl:hasDbXref "PMID:34401661" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4047048 ; owl:annotatedTarget "intramuscular glia" . [] oboInOwl:hasDbXref "PMID:24223998", "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047051 ; owl:annotatedTarget "An enterocyte of the human small intestine expressing bestrophin-4 (BEST4) calcium-activated ion channels. These enterocytes have a disinctive transcriptomic profile and are scattered through the small intestine epithelium." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000454 ; owl:annotatedTarget "ZFA:0009211" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:24223998", "PMID:34497389" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047052 ; owl:annotatedTarget "An enterocyte of the human colon expressing bestrophin-4 (BEST4) calcium-activated ion channels. These cells have a distinct transcriptomic profile compared to other enterocytes and are scattered through the colon epithelium." . [] oboInOwl:hasDbXref "GO:0048242" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000454 ; owl:annotatedTarget "adrenaline secreting cell" . [] oboInOwl:hasDbXref "PMID:33033253", "PMID:33628208", "PMID:35746551", "PMID:36750615", "PMID:39369473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047053 ; owl:annotatedTarget "A macrophage characterized by high expression of Triggering Receptor Expressed on Myeloid cells 2 (TREM2), found in various tissues including the liver, adipose tissue, bone, gut (Colonna, 2023), and tumor microenvironments, where it is associated with immunosuppressive and anti-inflammatory activity (Colmenares, 2024; Khantakova, 2022). This cell exhibits a distinct gene expression profile in the tumor microenvironment, including overexpression of complement system genes (C1QA, C1QB, C1QC, C3), and SPP1 in both mice and humans (Xiong, 2020; Khantakova, 2022). It is involved in phagocytosis, tissue repair, and modulation of immune responses (Coeho, 2021)." . [] oboInOwl:hasDbXref "PMID:39369473" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_4047053 ; owl:annotatedTarget "TREM-2 + resident macrophage" . [] oboInOwl:hasDbXref "PMID:35746551" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_4047053 ; owl:annotatedTarget "TREM2+ macrophage" . [] oboInOwl:hasDbXref "PMID:28845904", "PMID:33681216", "PMID:34302064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047054 ; owl:annotatedTarget "A dendritic cell capable of capturing antigens in peripheral tissues and migrating through blood or lymphatic vessels to secondary lymphoid organs, where it presents processed antigens to T cells. It expresses MHC class II molecules and lacks lineage markers associated with other leukocyte populations, distinguishing it as a member of the dendritic cell lineage. This cell plays a pivotal role in initiating and regulating adaptive immune responses by linking peripheral antigen capture with T cell activation in lymphoid tissues." . [] oboInOwl:hasDbXref "PMID:15579435", "PMID:26273695", "PMID:28261592", "doi:10.1002/hep.25595", "doi:10.1152/ajpgi.00227.2012" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047056 ; owl:annotatedTarget "A columnar, mucin-producing cholangiocyte that lines large bile ducts, including the hilar bile duct, right and left hepatic bile ducts, and large intrahepatic bile ducts. This cell expresses phosphorylated STAT3 and TFF-3 in humans and mice." . [] oboInOwl:hasDbXref "doi:10.1152/ajpgi.00227.2012" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_4047056 ; owl:annotatedTarget "mucin-secreting cholangiocyte" . [] oboInOwl:hasDbXref "ISBN:044174520" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000455 ; owl:annotatedTarget "Obsolete. Use PO:0004531 from Plant Ontology instead. A cell characterized by conspicuous and rather stable accumulation of starch." . [] oboInOwl:hasDbXref "PMID:20018251", "doi:10.21203/rs.3.rs-3229780/v1" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047060 ; owl:annotatedTarget "A circulating mononuclear phagocyte characterized by the expression of BCL-2-associated athanogene 3 (BAG3) protein, a co-chaperone involved in protein quality control and anti-apoptotic processes. (Fontanella, 2009). It undergoes cellular stress during the differentiation into M2 macrophages and is linked to poor survival rates in multiple cancer types. (Park, 2023)" . [] oboInOwl:hasDbXref "doi:10.21203/rs.3.rs-3229780/v1" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047060 ; owl:annotatedTarget "BAG3+ monocyte" . [] oboInOwl:hasDbXref "PMID:26330348", "PMID:26639736", "PMID:27798170", "PMID:31114585", "PMID:32351704", "PMID:34230995", "PMID:35865550" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4047101 ; owl:annotatedTarget "A natural killer cell resident to the liver, located in the hepatic sinusoids. In humans this cell type is distinguished from circulating natural killer cells by CD49a or CD69 gene expression. Liver-resident natural killer cells have also been shown to express CCR5, EOMES, KLRB1, GZMK, and CXCR6 in humans." . [] oboInOwl:hasDbXref "PMID:31114585" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047101 ; owl:annotatedTarget "he-NK" . [] oboInOwl:hasDbXref "doi:10.3389/fimmu.2019.00946" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047101 ; owl:annotatedTarget "hepatic NK" . [] oboInOwl:hasDbXref "doi:10.3389/fimmu.2019.00946" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047101 ; owl:annotatedTarget "hepatic natural killer cells" . [] oboInOwl:hasDbXref "PMID:33828559" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047101 ; owl:annotatedTarget "intrahepatic NK" . [] oboInOwl:hasDbXref "PMID:26639736" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047101 ; owl:annotatedTarget "liver NK cell" . [] oboInOwl:hasDbXref "PMID:26330348" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047101 ; owl:annotatedTarget "liver resident natural killer cell" . [] oboInOwl:hasDbXref "PMID:35726345" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4047101 ; owl:annotatedTarget "lr-NK" . [] oboInOwl:hasDbXref "PMID:34230995" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4047101 ; owl:annotatedTarget "Liver-resident natural killer cells play a crucial role in modulating the immune response during inflammation by balancing cytotoxic activity and cytokine production, thereby contributing to the maintenance of liver homeostasis and protection against excessive tissue damage." . [] oboInOwl:hasDbXref "PMID:25045600", "PMID:28067220", "PMID:37008045" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052001 ; owl:annotatedTarget "An ependymal cell that lines the lateral, third, and fourth ventricles of the brain. The cell is characterized by multiple motile cilia on its apical surface, which beats in a coordinated manner to facilitate the movement of cerebrospinal fluid (CSF), contributing to brain homeostasis." . [] oboInOwl:hasDbXref "PMID:25045600" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4052001 ; owl:annotatedTarget "multiciliated ependymal cells" . [] oboInOwl:hasDbXref "PMID:28067220", "PMID:37008045" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052001 ; owl:annotatedTarget "E1" . [] oboInOwl:hasDbXref "PMID:25045600", "PMID:27311928" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4052001 ; owl:annotatedTarget "multiciliated ependymal cell, with an average of 16 motile cilia per cell, exhibits two types of planar cell polarity (PCP): rotational polarity, with unidirectional cilia orientation, and translational polarity, with asymmetric cilia positioning in the apical area. This location-specific PCP varies across the ventricular wall, aligning with the direction of CSF flow. These cells are interconnected by adherens and gap junctions, which support intercellular communication and maintain the structural integrity of the ependymal layer. Unlike some other cell types, these cells lack tight junctions." . [] oboInOwl:hasDbXref "PMID:20851884", "Wikipedia:Syncytium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052002 ; owl:annotatedTarget "A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm." . [] oboInOwl:hasDbXref "WBbt:0008074" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052002 ; owl:annotatedTarget "syncytium" . ( ) . [] oboInOwl:hasDbXref "PMID:9067520" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052002 ; owl:annotatedTarget "SC" . [] oboInOwl:hasDbXref "PMID:18480313", "PMID:35810168", "PMID:38051275" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052003 ; owl:annotatedTarget "A capillary endothelial cell that is part of the intestinal villus. This cell is highly fenestrated, with fenestrations most numerous at the villus tips, and plays a vital role in nutrient absorption and maintaining the selective permeability of the intestinal barrier." . [] oboInOwl:hasDbXref "PMID:35810168" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4052003 ; owl:annotatedTarget "villus blood capillary endothelial cells" . [] oboInOwl:hasDbXref "PMID:38051275" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052003 ; owl:annotatedTarget "villus tip endothelial cell" . [] oboInOwl:hasDbXref "PMID:33707780", "PMID:35440118" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052004 ; owl:annotatedTarget "A specialized fibroblastic reticular cell that is part of gut-associated lymphoid tissue (GALT), responsible for forming a structural network that facilitates immune cell interactions. This cell is found in Peyer's patches, cryptopatches, and isolated lymphoid follicles. It plays crucial roles in maintaining intestinal immunity by controlling innate lymphoid cell homeostasis and function, organizing lymphoid structures, and contributing to intestinal microbiome balance." . [] oboInOwl:hasDbXref "PMID:33707780", "PMID:35440118" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_4052004 ; owl:annotatedTarget "Intestinal fibroblastic reticular cells develop from both perivascular and subepithelial progenitors during Peyer's patch formation. Intestinal fibroblastic reticular cells express key markers such as CCL19, CCL21, CXCL13, TNFSF13B (also known as BAFF), and produce IL-7, which are important for their immune regulatory functions and the organization of lymphoid structures." . [] oboInOwl:hasDbXref "PMID:35440118" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_4052004 ; owl:annotatedTarget "Ccl19-expressing fibroblastic reticular cell" . [] oboInOwl:hasDbXref "PMID:35440118" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_4052004 ; owl:annotatedTarget "solitary intestinal lymphoid tissue fibroblastic reticular cell" . [] oboInOwl:hasDbXref "PMID:35440118" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052004 ; owl:annotatedTarget "gut-associated secondary lymphoid organs fibroblastic reticular cell" . [] oboInOwl:hasDbXref "PMID:23143399", "PMID:26694715", "PMID:38877292" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052005 ; owl:annotatedTarget "A fibroblast that is part of the subserosa of intestine. This cell interacts with immune cells and play roles in inflammation and fibrosis. In certain conditions, such as Crohn's disease, subserosal fibroblast may differentiate into myofibroblasts." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000456 ; owl:annotatedTarget "Any secretory cell that is capable of some mineralocorticoid secretion." . [] oboInOwl:hasDbXref "PMID:31756561", "PMID:32531023", "PMID:35913117", "PMID:38260422", "doi:/10.1038/s41467-021-27901-5" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052006 ; owl:annotatedTarget "An epithelial cell that is part of the crypt of Lieberkuhn, originating from intestinal stem cells and giving rise to enteroendocrine cells (EECs). In mouse and human, this cell can be characterized by the expression of Neurog3, and has the ability to proliferate and differentiate into multiple EEC subtypes. Its proliferative potential contributes to crypt growth, distinguishing it from fully differentiated EECs." . [] oboInOwl:hasDbXref "PMID:31756561" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052006 ; owl:annotatedTarget "EEC Progenitor" . [] oboInOwl:hasDbXref "PMID:25670791" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4052006 ; owl:annotatedTarget "The EEC progenitor is also present in other organisms; for example, flies have EEC progenitors but lack intestinal crypts and do not express the same markers. Instead, they are Dl+ and Pros+." . [] oboInOwl:hasDbXref "PMID:30270042", "PMID:33430285", "PMID:33916891", "PMID:37080817" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052007 ; owl:annotatedTarget "A fibroblast located adjacent to the intestinal epithelium in both the small intestine and colon, specifically around the crypts. This cell is characterized by the expression of PDGFRα and various collagen isoforms, including COL4A5 and COL4A6. It secretes signalling molecules like TGF-β, Wnt ligands, and BMPs, which are crucial for epithelial homeostasis, intestinal stem cell support, and basement membrane formation." . [] oboInOwl:hasDbXref "PMID:30270042", "PMID:33916891" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052007 ; owl:annotatedTarget "S2 fibroblast" . [] oboInOwl:hasDbXref "PMID:33916891" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052007 ; owl:annotatedTarget "S2 mesenchymal cells" . [] oboInOwl:hasDbXref "PMID:30270042", "PMID:33916891", "PMID:37495570" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4052007 ; owl:annotatedTarget "The S2 fibroblast population has been identified as a subset of intestinal fibroblasts located near the epithelial lining. This population is divided into two subtypes: S2a and S2b. S2a is involved in epithelial differentiation, while S2b, located at the top of the crypt, regulates intestinal stem cell proliferation, niche formation, and wound healing." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000457 ; owl:annotatedTarget "ZFA:0009212" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:33916891", "doi:/10.1371/journal.pbio.3001032" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052008 ; owl:annotatedTarget "A subepithelial intestinal fibroblast that is located adjacent to the base of the crypt of Lieberkühn, near the intestinal stem cells. Characterized by low PDGFRα expression, this cell is crucial for maintaining the intestinal stem cell niche. Crypt-bottom fibroblast secretes key signaling molecules including canonical Wnt ligands (Wnt2, Wnt2b), Wnt potentiators (Rspo3), and BMP inhibitors (Grem1), which collectively regulate intestinal stem cell function and epithelial homeostasis." . [] oboInOwl:hasDbXref "doi:/10.1371/journal.pbio.3001032" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052008 ; owl:annotatedTarget "CBFs" . [] oboInOwl:hasDbXref "PMID:33916891" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052008 ; owl:annotatedTarget "bottom pericryptic-associated fibroblasts" . [] oboInOwl:hasDbXref "PMID:33916891", "doi:/10.1371/journal.pbio.3001032" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052009 ; owl:annotatedTarget "A subepithelial intestinal fibroblast that is located adjacent to the top of the crypt of Lieberkuhn. Characterized by high experession of PDGFRα, this cell secretes a range of signaling factors, including WNTs and BMPs, that drive epithelial differentiation, creating a gradient that regulates the balance between stem cell maintenance and differentiation." . [] oboInOwl:hasDbXref "doi:/10.1371/journal.pbio.3001032" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052009 ; owl:annotatedTarget "CTFs" . [] oboInOwl:hasDbXref "PMID:37495570" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052009 ; owl:annotatedTarget "S2b fibroblast" . [] oboInOwl:hasDbXref "PMID:33916891" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052009 ; owl:annotatedTarget "top pericryptic fibroblast" . [] oboInOwl:hasDbXref "PMID:37495570" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4052009 ; owl:annotatedTarget "S2b fibroblasts are located at the top of the crypt and express NRG1 and NPY." . [] oboInOwl:hasDbXref "PMID:20628033", "PMID:31320652", "PMID:36205477" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052010 ; owl:annotatedTarget "A stromal cell that serves as a precursor to the theca cell layers in the ovary growing follicles. This cell is present in the early stages of follicular growth, particularly in smaller follicles. Unlike mature theca cell, a pre-theca cell is initially non-steroidogenic and lacks luteinizing hormone receptors." . [] oboInOwl:hasDbXref "PMID:36205477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052010 ; owl:annotatedTarget "early theca cell" . [] oboInOwl:hasDbXref "PMID:31320652" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052010 ; owl:annotatedTarget "progenitor theca cell" . [] oboInOwl:hasDbXref "PMID:29339448", "PMID:34634036", "PMID:7107724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052011 ; owl:annotatedTarget "An enterocyte found in the follicle-associated epithelium (FAE) that covers Peyer's patches and other mucosa-associated lymphoid tissues. This cell has reduced absorptive capacity and expresses higher levels of chemokines CCL20 and CXCL16, compared to regular villus enterocytes. It contributes to antigen sampling and immune interactions, supporting the specialized function of the FAE in mucosal immunity." . [] oboInOwl:hasDbXref "PMID:7107724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052011 ; owl:annotatedTarget "follicle-associated epithelium enterocyte" . [] oboInOwl:hasDbXref "PMID:7107724" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052011 ; owl:annotatedTarget "FAE enterocyte" . [] oboInOwl:hasDbXref "PMID:7107724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052011 ; owl:annotatedTarget "follicular enterocyte" . [] oboInOwl:hasDbXref "PMID:15833266", "PMID:31320652", "PMID:32530882", "Wikipedia:Theca_interna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052012 ; owl:annotatedTarget "A specialized theca cell that forms the inner, highly vascularized layer of the theca surrounding ovarian follicles. Originating from progenitor theca cells, the theca interna cell is steroidogenic, playing a crucial role in the production of androgens, which serves as a precursor for estrogen synthesis in granulosa cells. This cell expresses luteinizing hormone receptors, enabling it to respond to hormonal signals that regulate steroidogenesis." . [] oboInOwl:hasDbXref "PMID:31320652" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052012 ; owl:annotatedTarget "inTC" . [] oboInOwl:hasDbXref "PMID:31320652" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052012 ; owl:annotatedTarget "interna TC" . [] oboInOwl:hasDbXref "PMID:31320652", "PMID:32530882", "PMID:36758341", "Wikipedia:Theca_externa" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052013 ; owl:annotatedTarget "A specialized theca cell that forms the outer layer of the theca surrounding the ovarian follicle, appearing at the antral follicle. Originating from progenitor theca cells, theca externa cell is characterized by its fibroblast-like appearance and primarily function to provide structural support to the developing follicle. This cell produces collagen fibers and extracellular matrix components such as Col1a1 and Col1a2." . [] oboInOwl:hasDbXref "PMID:31320652" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052013 ; owl:annotatedTarget "exTC" . [] oboInOwl:hasDbXref "PMID:31320652" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052013 ; owl:annotatedTarget "externa TC" . [] oboInOwl:hasDbXref "PMID:16607697", "PMID:27124642", "PMID:28396983", "PMID:33200981" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052014 ; owl:annotatedTarget "A capillary endothelial cell that is part of islet of Langerhans, characterized by a high density of fenestrations —approximately ten times greater than those in exocrine pancreatic capillaries. These fenestrations facilitate efficient hormone exchange, which is essential for maintaining glucose homeostasis. The cell's structure and function are regulated by the local production of vascular endothelial growth factor-A (VEGF-A), which maintains its fenestrated architecture." . [] oboInOwl:hasDbXref "PMID:16607697", "PMID:28396983" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4052014 ; owl:annotatedTarget "islet endothelial cell" . [] oboInOwl:hasDbXref "PMID:16607697" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4052014 ; owl:annotatedTarget "pancreatic islet endothelial cell" . [] oboInOwl:hasDbXref "PMID:18480313" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052015 ; owl:annotatedTarget "Any capillary endothelial cell that is part of an endocrine gland." . [] oboInOwl:hasDbXref "PMID:10810312", "PMID:32910242" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052016 ; owl:annotatedTarget "A capillary endothelial cell that is part of the pituitary gland. This cell is characterized by its fenestrated structure which facilitates the efficient transport of hormones and other signaling molecules, essential for endocrine signalling." . [] oboInOwl:hasDbXref "PMID:4899902" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4052016 ; owl:annotatedTarget "In the anterior pituitary gland of rats, capillary endothelial cells are distinguished by numerous fenestrations, which are covered by a single-layered diaphragm. The diaphragm features a dense ring-like structure." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19630576" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000458 ; owl:annotatedTarget "A cell type that secretes 5-Hydroxytryptamine (serotonin)." . [] oboInOwl:hasDbXref "PMID:18480313", "PMID:32375819", "https://www.ncbi.nlm.nih.gov/books/NBK27998/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052017 ; owl:annotatedTarget "A capillary endothelial cell that is part of the choroid plexus, characterized by its fenestrated nature with 60 to 80 nm fenestrations and lack of tight junctions. This fenestrated structure allows for the rapid delivery of water and other components, aiding in the production of cerebrospinal fluid (CSF)." . [] oboInOwl:hasDbXref "Wikipedia:Fallopian_tube" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052018 ; owl:annotatedTarget "Any epithelial cell that is part of the fallopian tube." . [] oboInOwl:hasDbXref "Wikipedia:Fallopian_tube" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4052018 ; owl:annotatedTarget "oviduct epithelial cell" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000458 ; owl:annotatedTarget "ZFA:0009213" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "Wikipedia:Fallopian_tube" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052018 ; owl:annotatedTarget "uterine tube epithelial cell" . [] oboInOwl:hasDbXref "doi:/10.1101/2022.06.17.496207" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052020 ; owl:annotatedTarget "A granzyme K-associated CD8 T cell that resides in the lung, characterized by the expression of granzyme K (GZMK), and tissue residency markers CD103 and CD49a. This cell exhibits cytotoxic potential through its expression of multiple granzymes (GZMA, GZMB, GZMH, GZMM) in addition to GZMK." . [] oboInOwl:hasDbXref "doi:/10.1101/2022.06.17.496207" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052020 ; owl:annotatedTarget "lung resident CD8-GZMK" . [] oboInOwl:hasDbXref "PMID:28322863", "doi:/10.1101/2022.06.17.496207" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4052020 ; owl:annotatedTarget "Lung resident granzyme K-associated CD8 T cell represents an intermediate stage of T cell differentiation, with GZMK expression peaking during this phase." . [] oboInOwl:hasDbXref "PMID:35704599", "PMID:37449888" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052021 ; owl:annotatedTarget "A CD8 T cell characterized by high expression of Granzyme K (GZMK). This cell is enriched in both inflamed tissues, such as synovial tissue in rheumatoid arthritis and respiratory tissues during COVID-19, as well as non-inflamed tissues like the gut and kidneys. Unlike highly cytotoxic GZMB+ CD8+ T cell, GZMK+ CD8+ T cell exhibits lower direct cytotoxic potential, and is involved in producing pro-inflammatory cytokines such as IFN-γ and TNF-α." . [] oboInOwl:hasDbXref "PMID:35704599" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052021 ; owl:annotatedTarget "granzyme K+ CD8 T cell" . [] oboInOwl:hasDbXref "PMID:35704599" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052021 ; owl:annotatedTarget "tissue-enriched expressing GzmK CD8 cell" . [] oboInOwl:hasDbXref "PMID:36347862" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_4052021 ; owl:annotatedTarget "GZMK high CD8+ T effector memory cell" . [] oboInOwl:hasDbXref "doi:/10.1101/2022.06.17.496207" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052021 ; owl:annotatedTarget "CD8-GZMK cell" . [] oboInOwl:hasDbXref "PMID:35704599" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052021 ; owl:annotatedTarget "TteK CD8 cell" . [] oboInOwl:hasDbXref "PMID:31183831", "PMID:31613440" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052022 ; owl:annotatedTarget "A smooth muscle cell that is part of the fallopian tube. This cell is responsible for peristaltic contractions that facilitate gamete and embryo transport, fluid mixing, and embryo admission to the uterus." . [] oboInOwl:hasDbXref "PMID:31613440" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4052022 ; owl:annotatedTarget "oviduct smooth muscle cell" . [] oboInOwl:hasDbXref "PMID:31613440" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052022 ; owl:annotatedTarget "uterine tube smooth muscle cell" . [] oboInOwl:hasDbXref "PMID:18621753" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4052022 ; owl:annotatedTarget "The fallopian tube smooth muscle cell in the human contracts dynamically in response to hormones and signaling molecules. Prostaglandins, particularly PGF2α and PGE2, have been shown to increase muscular contractions, while progesterone, levonorgestrel, mifepristone, oxytocin, and human chorionic gonadotropin (hCG) decrease them. These contractile responses are crucial for regulating gamete and embryo transport through the fallopian tube." . [] oboInOwl:hasDbXref "PMID:32929266", "PMID:36581776", "PMID:38559249", "PMID:39198675" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052023 ; owl:annotatedTarget "An epithelial cell that is part of the endometrial luminal epithelium, forming a continuous layer lining the uterine cavity. This cell undergoes cyclical changes during the menstrual cycle, proliferating under estrogen in the proliferative phase, and differentiating under progesterone in the secretory phase to prepare for potential implantation. During the window of implantation, this cell changes from a tall columnar shape to a shorter columnar or cuboidal form, loses polarity, and becomes receptive to blastocyst implantation." . [] oboInOwl:hasDbXref "PMID:39198675" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4052023 ; owl:annotatedTarget "The luminal endometrial unciliated epithelial cell expresses WNT7A, and LGR5 during the proliferative phase, transitioning to express VTCN1 and SULT1E1 in the early secretory phase, and LEFTY1, IL6, and PTGS1 in the mid- to late-secretory phases." . [] oboInOwl:hasDbXref "PMID:33311457", "PMID:33311464", "PMID:38398025" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052024 ; owl:annotatedTarget "A specialized muscle nucleus that is part of an extrafusal muscle fiber and overlaps the muscle-tendon junction, where muscle fibers connect to tendons. Characterized by a distinct transcriptional profile with the expression of genes like COL22A1, this myonucleus supports the structural integrity and function of the junction, playing a key role in transmitting the force generated by muscle contraction to the tendon." . [] oboInOwl:hasDbXref "PMID:33311464" ; oboInOwl:hasSynonymType obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052024 ; owl:annotatedTarget "myotendinous junction myonuclei" . [] oboInOwl:hasDbXref "PMID:33311457" ; oboInOwl:hasSynonymType obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052024 ; owl:annotatedTarget "myotendinous junction nuclei" . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052024 ; owl:annotatedTarget "MTJ nucleus" . [] oboInOwl:hasDbXref "PMID:33037211", "PMID:33311457", "PMID:33311464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052025 ; owl:annotatedTarget "A specialized muscle nucleus that is part of an extrafusal muscle fiber, clustered at the postsynaptic side of the neuromuscular junction. This nucleus exhibits a distinct transcriptional profile, including acetylcholine receptor (AChR) subunit genes. It regulates the production of proteins essential for maintaining the structure and function of the neuromuscular junction, supporting efficient nerve-muscle signaling for muscle contraction." . [] oboInOwl:hasDbXref "PMID:33311464" ; oboInOwl:hasSynonymType obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052025 ; owl:annotatedTarget "neuromuscular junction myonuclei" . [] oboInOwl:hasDbXref "PMID:33311457" ; oboInOwl:hasSynonymType obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052025 ; owl:annotatedTarget "neuromuscular junction nuclei" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:068340007X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000459 ; owl:annotatedTarget "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052025 ; owl:annotatedTarget "NMJ nuclues" . [] oboInOwl:hasDbXref "PMID:34727990", "PMID:35908794", "PMID:36361732", "doi:10.1101/2024.05.15.594276" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052026 ; owl:annotatedTarget "A fast type II muscle cell that is part of the skeletal muscle tissue. This cell is characterized by its intermediate metabolic profile, utilizing both glycolytic and oxidative pathways for energy production. In humans, it is distinguished by the expression of myosin heavy chain 1 (MYH1)." . [] oboInOwl:hasDbXref "PMID:34727990" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052026 ; owl:annotatedTarget "type 2x fiber" . [] oboInOwl:hasDbXref "PMID:34727990" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052026 ; owl:annotatedTarget "type 2x muscle cell" . [] oboInOwl:hasDbXref "PMID:34727990" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052026 ; owl:annotatedTarget "type 2x muscle fiber" . [] oboInOwl:hasDbXref "doi:10.1101/2024.05.15.594276" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052026 ; owl:annotatedTarget "type IIx muscle fiber" . [] oboInOwl:hasDbXref "PMID:27199166", "PMID:34727990" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4052026 ; owl:annotatedTarget "In humans, type IIx fiber contains high levels of MYLK2, enhancing contraction speed and force via myosin phosphorylation, especially under low calcium. This mechanism supports post-activation potentiation, increasing force output in fast-twitch muscles. Additionally, this fiber has abundant ACTN3 (α-actinin-3), linked to muscle power, and exhibits the highest shortening velocity among human muscle fiber types. Notably, type IIx fiber is selectively lost in aging-related sarcopenia, increases in proportion in type 2 diabetes and obesity, and is the first to degenerate in Duchenne Muscular Dystrophy, impacting muscle function across various conditions." . [] oboInOwl:hasDbXref "PMID:20628033", "PMID:38069168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052027 ; owl:annotatedTarget "A theca cell undergoing atresia, characterized by distinct morphological changes including hypertrophy, altered cell shape, and disrupted layered organization. This cell exhibits reduced steroidogenic capacity and changes in surrounding vascularization. The onset of theca cell atresia can vary, occurring at different stages of follicle atresia depending on the phase of folliculogenesis." . [] oboInOwl:hasDbXref "PMID:38069168" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4052027 ; owl:annotatedTarget "During atresia, theca interna and externa cells undergo distinct morphological and functional changes. Theca interna cells round up, expand in cytoplasmic area, and thicken the internal layer as organization degrades, while showing reduced STAR expression, which lowers androgen production. Theca externa cells display decreased ACTA2 expression, weakening structural integrity." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000459 ; owl:annotatedTarget "ZFA:0009214" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:35720413", "PMID:39198675", "Wikipedia:Uterine_natural_killer_cells" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052028 ; owl:annotatedTarget "A natural killer cell that is part of the uterus, specifically within the endometrium during the non-pregnant state and in the decidua during pregnancy. This cell exhibits dynamic changes in frequency throughout the menstrual cycle, with lower levels during menstruation and a significant increase during the mid-secretory phase and early pregnancy." . [] oboInOwl:hasDbXref "PMID:35720413" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_4052028 ; owl:annotatedTarget "endometrial natural killer cell" . [] oboInOwl:hasDbXref "PMID:39198675" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052028 ; owl:annotatedTarget "uNK cell" . [] oboInOwl:hasDbXref "PMID:36543915", "PMID:36769178", "PMID:37291214" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052029 ; owl:annotatedTarget "A fibroblast that is located beneath the visceral pleura of the lung. This cell contributes to the development of idiopathic pulmonary fibrosis (IPF) by forming fibrotic lesions that originate subpleurally and extend into lung tissue through activation, proliferation, migration, and differentiation into a myofibroblast." . [] oboInOwl:hasDbXref "PMID:28705796", "PMID:36718802" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052030 ; owl:annotatedTarget "A fibroblast of the adventitia of a blood vessel. This cell contributes to vascular homeostasis, remodeling, and inflammation by producing extracellular matrix components, cytokines, and growth factors. Adventitial fibroblast can transition into an activated state during injury or disease, marked by increased proliferation, migration, matrix deposition, and contractile protein expression" . [] oboInOwl:hasDbXref "PMID:36718802" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4052030 ; owl:annotatedTarget "Single-cell transcriptomics of murine aorta identifies two adventitial fibroblast-specific markers, PDGFRA and DPEP1, which were validated at the protein level by immunohistochemistry and flow cytometry across human and murine arteries, highlighting fibroblast heterogeneity in health and cardiovascular disease (CVD) in humans and mice." . [] oboInOwl:hasDbXref "PMID:35355013", "PMID:36796082" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052031 ; owl:annotatedTarget "A secretory epithelial cell of the respiratory and terminal bronchioles." . [] oboInOwl:hasDbXref "PMID:36796082" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052031 ; owl:annotatedTarget "RAS cell" . [] oboInOwl:hasDbXref "PMID:35355018" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052031 ; owl:annotatedTarget "terminal and respiratory bronchioles secretory cell" . [] oboInOwl:hasDbXref "PMID:35355013", "PMID:36796082" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4052031 ; owl:annotatedTarget "The respiratory airway secretory cell is cuboidal and has a unique transcriptomic profile compared to other epithelial cells in the same region. In humans, it functions as a multipotent progenitor, capable of regenerating alveolar type 2 (AT2) cells." . [] oboInOwl:hasDbXref "PMID:35389781" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052032 ; owl:annotatedTarget "A CD8 T cell characterized by high expression of Granzyme H (GZMH). This cell exhibits a restricted TCR repertoire and elevated expression of cytotoxic, exhaustion, and type I interferon-stimulated gene signatures compared to controls." . [] oboInOwl:hasDbXref "PMID:35389781" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052032 ; owl:annotatedTarget "granzyme H+ CD8 T cell" . [] oboInOwl:hasDbXref "PMID:35389781" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052032 ; owl:annotatedTarget "GZMH+ CD8+ T cell" . [] oboInOwl:hasDbXref "PMID:35389781" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4052032 ; owl:annotatedTarget "This cell type is significantly expanded in systemic lupus erythematosus (SLE) patients. Unlike other CD8 T cell populations, GZMH+ CD8 T cells can comprise up to 50% of all lymphocytes in some SLE patients." . [] oboInOwl:hasDbXref "PMID:35245089", "PMID:37863104" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052033 ; owl:annotatedTarget "A tuft cell that is part of the extrahepatic biliary tree, including the gallbladder and extrahepatic bile ducts. It shares a core genetic program with intestinal tuft cells but has unique tissue-specific genes. Biliary tuft cell functions as a bile acid-sensitive regulator, suppressing inflammation and modulating microbiome-dependent neutrophil infiltration in biliary tissues. Unlike its intestinal counterparts, this cell decreases in number postnatally as bile acid production matures, with its abundance negatively regulated by bile acids." . [] oboInOwl:hasDbXref "PMID:35245089" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052033 ; owl:annotatedTarget "gallbladder/extrahepatic bile duct tuft cell" . [] oboInOwl:hasDbXref "PMID:30022164", "PMID:30904566", "PMID:35668088", "PMID:36351364", "PMID:36961668" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052034 ; owl:annotatedTarget "A tuft cell that is part of the medullary epithelium of the thymus, characterized by lateral microvilli and specific markers, including L1CAM in both mice (Zhang et al., 2022) and humans (Sun et al., 2023), as well as MHC II in mice (Miller et al., 2018). This cell is pivotal in immune functions such as antigen presentation, central tolerance, and type 2 immunity. A tuft cell in the thymus exhibits characteristics of both a medullary thymic epithelial cell (mTEC) and a peripheral tuft cell. Its development is governed by transcription factors such as POU2F3." . [] oboInOwl:hasDbXref "PMID:30904566" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052034 ; owl:annotatedTarget "thymic tuft cell" . [] oboInOwl:hasDbXref "PMID:30904566" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4052034 ; owl:annotatedTarget "A thymic tuft cell is a subset of terminally differentiated medullary thymic epithelial cell comprising 5-10% of total mTECs. Lineage-tracing studies indicate that this cell arises from mature MHCII mTECs, with development occurring through both Aire-dependent and Aire-independent pathways. However, its exact origins remain unclear." . [] oboInOwl:hasDbXref "PMID:30904566", "PMID:32717220" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052035 ; owl:annotatedTarget "A tuft cell that is part of the epithelium of pancreatic duct. Present in humans and rats, this cell is absent in the murine pancreas under normal conditions but emerges during acinar-to-ductal metaplasia triggered by injury, inflammation, or oncogenic mutations. It modulates the immune response and protects against pancreatic ductal adenocarcinoma progression by producing suppressive eicosanoids, such as prostaglandin D2. A tuft cell in the pancreatic duct highly expresses the transcription factor POU2F3, which is essential for its development and presence." . [] oboInOwl:hasDbXref "PMID:9749964" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052035 ; owl:annotatedTarget "pancreatic brush cell" . [] oboInOwl:hasDbXref "PMID:32717220" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052035 ; owl:annotatedTarget "pancreatic tuft cell" . [] oboInOwl:hasDbXref "PMID:30379593", "PMID:38306414" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052036 ; owl:annotatedTarget "A tuft cell that is part of the nasal cavity epithelium, located in both the respiratory and olfactory epithelia of the nose. This cell plays key roles in chemosensation, lipid mediator production, immune responses, and epithelial homeostasis." . [] oboInOwl:hasDbXref "PMID:34692913" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052036 ; owl:annotatedTarget "nasal brush cell" . [] oboInOwl:hasDbXref "PMID:38306414" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052036 ; owl:annotatedTarget "nasal tuft cell" . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000460 ; owl:annotatedTarget "Any secretory cell that is capable of some glucocorticoid secretion." . [] oboInOwl:hasDbXref "PMID:38306414", "doi:/10.1101/2022.09.26.509561" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052037 ; owl:annotatedTarget "A tuft cell that is part of the olfactory epithelium, characterized by a globular body and the expression of neurogranin (Nrgn) in mice. This cell plays a crucial role in allergen recognition and regulating olfactory stem cell proliferation via TRPM5-dependent ATP sensing and cysteinyl leukotriene production. Unlike nasal respiratory tuft cells, it has low to absent expression of taste receptors, including the G protein Gα gustducin, and rarely contacts olfactory sensory neurons directly." . [] oboInOwl:hasDbXref "PMID:38306414" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052037 ; owl:annotatedTarget "olfactory tuft cell" . [] oboInOwl:hasDbXref "PMID:38306414" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052037 ; owl:annotatedTarget "TPRM5+ tuft-MVC" . [] oboInOwl:hasDbXref "PMID:38306414" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052037 ; owl:annotatedTarget "TRPM5+ microvillous cell" . [] oboInOwl:hasDbXref "doi:/10.1101/2022.09.26.509561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052037 ; owl:annotatedTarget "TRPM5+ microvillous tuft cell" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000460 ; owl:annotatedTarget "ZFA:0009215" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:38306414" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052037 ; owl:annotatedTarget "tuft-microvillous cell" . [] oboInOwl:hasDbXref "PMID:30379593", "PMID:34932383", "PMID:38306414" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052038 ; owl:annotatedTarget "A tuft cell that is part of the nasal cavity respiratory epithelium. Acting as a chemosensor, it detects bitter taste ligands and bacterial signals via taste receptors, maintaining epithelial-microbial homeostasis by stimulating antimicrobial peptide secretion from adjacent epithelial cells. This cell is a major source of IL-25, promoting type 2 immune responses and potentially contributing to chronic rhinosinusitis (O'Leary et al., 2019)." . [] oboInOwl:hasDbXref "PMID:38306414" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052038 ; owl:annotatedTarget "Gɑ-gustducin high respiratory tuft cell" . [] oboInOwl:hasDbXref "PMID:38306414" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052038 ; owl:annotatedTarget "nasal respiratory solitary chemosensory cell" . [] oboInOwl:hasDbXref "PMID:38306414" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052038 ; owl:annotatedTarget "tuft-solitary chemosensory cell" . [] oboInOwl:hasDbXref "PMID:35993302", "PMID:38098741", "PMID:8874101" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052039 ; owl:annotatedTarget "A tuft cell that is part of the epithelium of the submandibular gland, localized to the striated ducts in mice, pigs, and humans, and to the main excretory ducts in rats. This cell is characterized by chemosensory functions, potential roles in immune regulation, and possible involvement in salivary secretion via acetylcholine release." . [] oboInOwl:hasDbXref "doi:10.1016/S0925-4773(97)00654-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000462 ; owl:annotatedTarget "A cell of mesodermal origin that is closely associated with the epithelium of an imaginal disc. It is a precursor of some of the insect's adult muscles." . [] oboInOwl:hasDbXref "PMID:22527717", "PMID:38117182", "doi:/10.1101/2022.02.16.480779" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052040 ; owl:annotatedTarget "A tuft cell that is part of the epithelium of the stomach. This cell is characterized by gastric chemosensation and immune regulation through IL-25 secretion, which activates ILC2s to produce IL-13, driving epithelial remodelling and tuft cell expansion. Unlike intestinal tuft cells, which are primarily involved in helminth defense and type 2 immunity, the tuft cell of the stomach is primarily involved in inflammation, metaplasia, and hyperplasia." . [] oboInOwl:hasDbXref "PMID:38117182" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052040 ; owl:annotatedTarget "gastric tuft cell" . [] oboInOwl:hasDbXref "PMID:30379593", "PMID:32733896" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052041 ; owl:annotatedTarget "A tuft cell that is part of the epithelium of the pharyngotympanic (auditory) tube. This chemosensory cell is often positioned near cholinoreceptive sensory nerve fibers, suggesting a role in neuroimmune communication. It detects chemical signals and releases neuropeptides, such as acetylcholine (ACh) and CGRP, which contribute to inflammatory responses that help protect deeper tissues from harmful substances." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000462 ; owl:annotatedTarget "FBbt:00003219" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:30379593", "PMID:36993541", "PMID:38548667" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052042 ; owl:annotatedTarget "A tuft cell that is part of the epithelium of the urethra. This cell monitors urethral contents by detecting chemical stimuli, such as bitter compounds and sugars. Upon activation, it stimulates sensory nerve fibres and triggers detrusor muscle contraction, likely aiding in pathogen clearance by promoting bladder emptying." . [] oboInOwl:hasDbXref "PMID:38548667" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052042 ; owl:annotatedTarget "urethral brush cell" . [] oboInOwl:hasDbXref "PMID:38548667" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052042 ; owl:annotatedTarget "urethral cholinergic chemosensory cell" . [] oboInOwl:hasDbXref "PMID:38548667" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052042 ; owl:annotatedTarget "urethral tuft cell" . [] oboInOwl:hasDbXref "PMID:27680547" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4052042 ; owl:annotatedTarget "Urethral tuft cells are heterogeneous, with both cholinergic and non-cholinergic populations present." . [] oboInOwl:hasDbXref "PMID:36205477", "doi:/10.1101/2024.12.15.628550" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052045 ; owl:annotatedTarget "A stromal cell that is part of the ovarian stroma, characterized by its ability to synthesize steroid hormones." . [] oboInOwl:hasDbXref "PMID:36205477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4052045 ; owl:annotatedTarget "steroidogenic interstitial stromal cell" . [] oboInOwl:hasDbXref "PMID:36205477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4052045 ; owl:annotatedTarget "steroidogenic stromal cell" . [] oboInOwl:hasDbXref "PMID:36205477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052045 ; owl:annotatedTarget "Enpp2− interstitial cell" . [] oboInOwl:hasDbXref "PMID:36205477", "doi:/10.1101/2024.12.15.628550" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052046 ; owl:annotatedTarget "A luteal cell that is part of the young, developing corpus luteum. This cell promotes progesterone synthesis, marked by high Parm1 expression in mice (Lan et al., 2024). An early luteal cell is associated with steroidogenesis and cell growth, contributing to early corpus luteum function and maturation." . [] oboInOwl:hasDbXref "PMID:36205477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052046 ; owl:annotatedTarget "active corpus luteum cell" . [] oboInOwl:hasDbXref "PMID:31803139", "PMID:36205477", "doi:/10.1101/2024.12.15.628550" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052047 ; owl:annotatedTarget "A luteal cell that is part of the older, regressing corpus luteum. This cell exhibits increased expression of genes involved in progesterone metabolism - Akr1c18 in mice (Lan et al., 2024), cell cycle arrest, and apoptosis. A late luteal cell contributes to corpus luteum regression and eventual clearance from the ovary through luteolysis." . [] oboInOwl:hasDbXref "PMID:36205477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052047 ; owl:annotatedTarget "regressing corpus luteum cell" . [] oboInOwl:hasDbXref "PMID:30855909", "PMID:35799078", "PMID:36726292", "PMID:37724716" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052048 ; owl:annotatedTarget "A cuboidal epithelial cell that is part of the intercalated duct of salivary gland. This cell expresses proteins commonly associated with acinar cells and displays calcium signaling characteristics similar to secretory cells, indicating an active role in the secretory process rather than ion reabsorption." . [] oboInOwl:hasDbXref "FlyBase:ds", "ISBN:ISBN:978-0801481253" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000463 ; owl:annotatedTarget "An epidermal cell that secretes chitinous cuticle from its apical side." . [] oboInOwl:hasDbXref "PMID:37724716" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4052048 ; owl:annotatedTarget "intercalated duct cell" . [] oboInOwl:hasDbXref "PMID:37724716" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052048 ; owl:annotatedTarget "salivary intercalated duct cells" . [] oboInOwl:hasDbXref "PMID:35799078" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052048 ; owl:annotatedTarget "Id cell" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM466.TLJQ.498" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4052048 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/mouth-parotid-gland/v1.0/assets/2d-ftu-mouth-parotid-gland.png" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM664.JPSV.649" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4052048 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/mouth-sublingual-gland/v1.0/assets/2d-ftu-mouth-sublingual-gland.png" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM632.XNRG.877" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4052048 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/mouth-submandibular-gland/v1.0/assets/2d-ftu-mouth-submandibular-gland.png" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000463 ; owl:annotatedTarget "FBbt:00007325" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:30855909", "PMID:34147989", "PMID:36726292" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052049 ; owl:annotatedTarget "An columnar/cuboidal epithelial cell that is part of the striated duct of salivary gland, characterized by basal striations formed by infoldings of the plasma membrane. This cell play a crucial role in modifying the electrolyte composition and concentration of saliva through active ion transport, particularly the absorption of sodium and secretion of potassium." . [] oboInOwl:hasDbXref "PMID:11590591" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4052049 ; owl:annotatedTarget "SD cells" . [] oboInOwl:hasDbXref "PMID:11590591" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4052049 ; owl:annotatedTarget "striated duct cells" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM466.TLJQ.498" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4052049 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/mouth-parotid-gland/v1.0/assets/2d-ftu-mouth-parotid-gland.png" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM632.XNRG.877" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_4052049 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/mouth-submandibular-gland/v1.0/assets/2d-ftu-mouth-submandibular-gland.png" . [] oboInOwl:hasDbXref "PMID:36273006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052050 ; owl:annotatedTarget "An epithelial cell that is part of an endometrium luminal epithelium." . [] oboInOwl:hasDbXref "PMID:31317179" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052050 ; owl:annotatedTarget "endometrial luminal epithelial cell" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:7576311" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000464 ; owl:annotatedTarget "An epidermal progenitor cell that arises from neuroectoderm and in turn gives rise to the epidermal sheath of ventral and cephalic regions." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000464 ; owl:annotatedTarget "FBbt:00004994" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:30429548", "PMID:34512661", "PMID:34857954", "PMID:35784314", "PMID:39198675" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052051 ; owl:annotatedTarget "​​A uterine natural killer subset that is present in the endometrial lining during the non-pregnant state (Garcia-Alonso et al., 2021) and in the decidua during pregnancy (Vento-Tormo et al., 2018). It expresses the uterine resident marker CD49a and is distinguished from uNK2 and uNK3 by CD39 expression and the absence of CD103 (Whettlock et al., 2022) and CD160 (Marečková et al., 2024). It also expresses higher levels of killer-cell immunoglobulin-like receptors (KIRs) and leukocyte immunoglobulin-like receptor B1 (LILRB1), which facilitate interaction with human leukocyte antigens (HLAs) on extravillous trophoblast cells, promoting immune tolerance and implantation. Enriched in the endometrium post-ovulation (Marečková et al., 2024) and prominent in early pregnancy (Whettlock et al., 2022), uNK1 regulates trophoblast invasion and spiral artery remodeling (Zhang & Wei, 2021)." . [] oboInOwl:hasDbXref "PMID:30429548" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_4052051 ; owl:annotatedTarget "decidual natural killer cell 1" . [] oboInOwl:hasDbXref "PMID:39198675" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052051 ; owl:annotatedTarget "uNK1" . [] oboInOwl:hasDbXref "doi:10.1007/BF00360522" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000465 ; owl:annotatedTarget "A precursor of the cells that form the dorsal vessel of arthropods." . [] oboInOwl:hasDbXref "PMID:30429548", "PMID:34857954", "PMID:35784314", "PMID:39198675" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052052 ; owl:annotatedTarget "A uterine natural killer subset that is present in the endometrial lining during the non-pregnant state (Garcia-Alonso et al., 2021) and in the decidua during pregnancy (Vento-Tormo et al., 2018), peaking in the first trimester. It expresses the uterine resident marker CD49a and is distinguished from uNK1 and uNK3 by the absence of CD39, CD103 (Whettlock et al., 2022), and CD160 (Marečková et al., 2024), with ITGB2 serving as a defining marker (Vento-Tormo et al., 2018). Functionally, it produces more cytokines upon stimulation than uNK1, suggesting a role in immune defense, and secretes XCL1 chemokines, facilitating interactions with maternal dendritic cells and fetal extravillous trophoblasts (Vento-Tormo et al., 2018)." . [] oboInOwl:hasDbXref "PMID:30429548" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_4052052 ; owl:annotatedTarget "decidual natural killer cell 2" . [] oboInOwl:hasDbXref "PMID:39198675" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052052 ; owl:annotatedTarget "uNK2" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000465 ; owl:annotatedTarget "FBbt:00001666" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:30429548", "PMID:31959757", "PMID:34857954", "PMID:35784314", "PMID:39198675" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052053 ; owl:annotatedTarget "A uterine natural killer subset found in the endometrial lining during the non-pregnant state (Garcia-Alonso et al., 2021) and in the decidua during pregnancy (Vento-Tormo et al., 2018), becoming the dominant uNK subset late in pregnancy. It expresses the uterine resident marker CD49a and is distinguished from uNK1 and uNK2 by CD160 (Marečková et al., 2024) and CD103 expression, the absence of CD39, and low KIR levels (Whettlock et al., 2022). Resembling intraepithelial ILC1 cells, uNK3 primarily supports uterine immune defense (Huhn et al., 2020) and indirectly influences trophoblast behavior through chemokine secretion, such as CCL5 (Vento-Tormo et al., 2018)." . [] oboInOwl:hasDbXref "PMID:30429548" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_4052053 ; owl:annotatedTarget "decidual natural killer cell 3" . [] oboInOwl:hasDbXref "PMID:39198675" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4052053 ; owl:annotatedTarget "uNK3" . [] oboInOwl:hasDbXref "PMID:30714682", "PMID:30875134" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052055 ; owl:annotatedTarget "A mature NK T cell that can be identified by the expression of CD56 in humans." . [] oboInOwl:hasDbXref "https://orcid.org/0009-0000-8480-9277" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052055 ; owl:annotatedTarget "mature NK T lymphocyte, human" . [] oboInOwl:hasDbXref "https://orcid.org/0009-0000-8480-9277" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052055 ; owl:annotatedTarget "mature NK T-cell, human" . [] oboInOwl:hasDbXref "https://orcid.org/0009-0000-8480-9277" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052055 ; owl:annotatedTarget "mature NK T-lymphocyte, human" . [] oboInOwl:hasDbXref "https://orcid.org/0009-0000-8480-9277" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052055 ; owl:annotatedTarget "mature NKT cell, human" . [] oboInOwl:hasDbXref "https://orcid.org/0009-0000-8480-9277" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052055 ; owl:annotatedTarget "mature natural killer T cell, human" . [] oboInOwl:hasDbXref "https://orcid.org/0009-0000-8480-9277" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052055 ; owl:annotatedTarget "mature natural killer T lymphocyte, human" . [] oboInOwl:hasDbXref "https://orcid.org/0009-0000-8480-9277" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052055 ; owl:annotatedTarget "mature natural killer T-lymphocyte, human" . [] oboInOwl:hasDbXref "PMID:19834574", "PMID:2274847", "PMID:30415995", "Wikipedia:Merkel_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052058 ; owl:annotatedTarget "A Merkel cell found mainly in the basal layer of the epidermis and the outer root sheath of hair follicles, particularly concentrated in areas with high tactile acuity, such as touch domes, hair follicles, and fingertips." . [] oboInOwl:hasDbXref "PMID:6207057" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052058 ; owl:annotatedTarget "epdiermal Merkel cell" . [] oboInOwl:hasDbXref "PMID:34283481", "wikipedia:Spinous_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052060 ; owl:annotatedTarget "A differentiating keratinocyte found in the epidermis and oral epithelium, located in the stratum spinosum, characterized by a spiny appearance due to abundant intercellular desmosomal junctions." . [] oboInOwl:hasDbXref "wikipedia:Spinous_cell" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052060 ; owl:annotatedTarget "prickle cell" . [] oboInOwl:hasDbXref "MESH:D015603", "PMID:15749908", "PMID:19727116", "PMID:38473275", "PMID:39115524", "wikipedia:Keratinocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052061 ; owl:annotatedTarget "A keratinocyte of the skin epidermis that synthesizes keratin and undergoes successive stages of differentiation as it migrates from the basal layer to the cornified (stratum corneum) layer. These differentiation stages include the basal, spinous (prickle), and granular cell layers. This cell is central to epidermal homeostasis, mediating wound healing, immune modulation, including the secretion of cytokines and chemokines that recruit neutrophils (Simmons and Gallo, 2024), and intercellular communication with adjacent melanocytes (Marrapodi and Bellei, 2024)." . [] oboInOwl:hasDbXref "PMID:39185948" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4052061 ; owl:annotatedTarget "skin keratinocyte" . [] oboInOwl:hasDbXref "PMID:15749908", "PMID:19727116" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4052061 ; owl:annotatedTarget "Keratinocytes are reportedly CDw210a(IL-10RA)-negative , CDw210b(IL-10RB)-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive." . [] oboInOwl:hasDbXref "PMID:34099859", "PMID:35853486", "PMID:39044464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4052062 ; owl:annotatedTarget "A specialized fibroblast located in the onychodermis that play a key role in nail growth and regeneration by interacting with LGR6-positive nail matrix keratinocytes. These interactions mediate essential signaling pathways, particularly WNT signaling, which is critical for epithelial–mesenchymal communication and coordinated nail development. In humans, this cell expresses key markers, including RSPO4, MSX1, WIF1, and BMP5, all involved in nail differentiation." . [] oboInOwl:hasDbXref "doi:10.1007/978-3-642-71516-7_2" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4070010 ; owl:annotatedTarget "A motor neuron that moves the medial tooth forward" . [] oboInOwl:hasDbXref "doi:10.1007/978-3-642-71516-7_2" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4070011 ; owl:annotatedTarget "A motor neuron that closes the lateral teeth." . [] oboInOwl:hasDbXref "doi:10.1007/978-3-642-71516-7_2" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4070012 ; owl:annotatedTarget "A motor neuron that controls ventral stomach grooves leading to pyloric filter." . [] oboInOwl:hasDbXref "doi:10.1007/978-3-642-71516-7_2" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4070013 ; owl:annotatedTarget "A motor neuron that controls ventral stomach grooves leading to pyloric filter." . [] oboInOwl:hasDbXref "PMID:6296329", "doi:10.1007/978-3-642-71516-7_2" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4070014 ; owl:annotatedTarget "A motor neuron that controls pyloric filter movements; innervates the pyloric muscle." . [] oboInOwl:hasDbXref "GOC:tfm", "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000467 ; owl:annotatedTarget "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." . [] oboInOwl:hasDbXref "PMID:6296329", "doi:10.1007/978-3-642-71516-7_2" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4070015 ; owl:annotatedTarget "A motor neuron that controls the cardiopyloric valve." . [] oboInOwl:hasDbXref "PMID:6296329", "doi:10.1007/978-3-642-71516-7_2" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4070016 ; owl:annotatedTarget "Pyloric pacemaker neuron that provides feedback to commissural ganglia (CoG) neurons." . [] oboInOwl:hasDbXref "PMID:6296329", "doi:10.1007/978-3-642-71516-7_2" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4070017 ; owl:annotatedTarget "A motor neuron that controls pyloric filter movements; innervates the lateral pyloric muscle." . [] oboInOwl:hasDbXref "PMID:27284195", "PMID:39233334" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4072001 ; owl:annotatedTarget "A post-mitotic oligodendrocyte that has exited the cell cycle and begun early stage differentiation. The cell begins to acquire oligodendrocyte-like characteristics but has not yet initiated myelination. In mice, NFOL is marked by the expression of Tcf7l2 and Cemip2 (also known as Tmem2), among other early myelin-related genes. These markers highlight cells transitioning from a precursor to a more differentiated, pre-myelinating state." . [] oboInOwl:hasDbXref "PMID:27284195" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4072001 ; owl:annotatedTarget "NFOL" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000467 ; owl:annotatedTarget "ZFA:0009216" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:27284195", "PMID:30837646", "PMID:39233334", "PMID:9473608" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4072002 ; owl:annotatedTarget "A postmitotic and differentiated oligodendrocyte derived from a oligodendrocyte progenitor cell. A myelin-forming oligodendrocyte begins the expression of myelin genes and actively engages in the myelination process. In mice and humans, it is characterized by the upregulation of the key myelin-associated markers Mbp and Opalin. Additionally, Ctps (CTP synthase) shows peak expression at this stage, suggesting a heightened demand for nucleotide biosynthesis during membrane expansion and myelin production." . [] oboInOwl:hasDbXref "PMID:39233334" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4072002 ; owl:annotatedTarget "MFOL" . [] oboInOwl:hasDbXref "PMID:27284195", "PMID:33203872" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4072003 ; owl:annotatedTarget "A post-mitotic oligodendrocyte derived from a myelin-forming oligodendrocyte (MFOL). A mature Myelinating Oligodendrocyte is a fully differentiated cell that is actively engaged in myelination. In addition to high expression of canonical myelin genes (e.g., Mbp, Plp1, Mog), a MOL can be distinguished by the expression of stage-enriched genes Grm3, Klk6, Ptgds, Anxa5, and Hopx in mice. These markers reflect the functional specialization of a mature oligodendrocyte, including roles in signalling, lipid metabolism, and myelin maintenance." . [] oboInOwl:hasDbXref "PMID:27284195" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4072003 ; owl:annotatedTarget "MOL" . [] oboInOwl:hasDbXref "PMID:32869307", "PMID:33756109", "PMID:34532720", "PMID:8514911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4072005 ; owl:annotatedTarget "A type of midbrain dopaminergic neuron localized in the retrorubral field which projects to limbic and cortical regions involved in emotion, motivation, and reward." . [] oboInOwl:hasDbXref "PMID:33756109" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4072005 ; owl:annotatedTarget "A8 dopamine neuron" . [] oboInOwl:hasDbXref "GO:0051458" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000467 ; owl:annotatedTarget "ACTH secreting cell" . [] oboInOwl:hasDbXref "PMID:23603197", "PMID:24843012", "PMID:26430123", "PMID:32869307", "PMID:38092916", "PMID:39961377" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4072006 ; owl:annotatedTarget "A type of dopaminergic neuron in the substantia nigra involved in motor control and particularly vulnerable in Parkinson’s disease. In mice, it is notable for its heterogeneous co-release of dopamine with either glutamate or GABA. It releases GABA through alternative synthesis pathways or reuptake mechanisms independent of GAD expression." . [] oboInOwl:hasDbXref "PMID:20049900" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4072006 ; owl:annotatedTarget "A9 nigral dopamine neuron" . [] oboInOwl:hasDbXref "PMID:31704946" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4072006 ; owl:annotatedTarget "substantia nigra dopaminergic neuron" . [] oboInOwl:hasDbXref "PMID:23603197", "PMID:3107759", "PMID:32869307" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4072007 ; owl:annotatedTarget "A type of dopaminergic neuron found in the ventral tegmental area that is involved in reward processes, motivation and addiction." . [] oboInOwl:hasDbXref "PMID:3107759" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4072007 ; owl:annotatedTarget "A10 VTA Dopaminergic Neuron" . [] oboInOwl:hasDbXref "PMID:25343491", "PMID:37522391", "PMID:8978475" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4072008 ; owl:annotatedTarget "A type of hypothalamic dopaminergic neuron found in the posterior hypothalamus, projecting to the spinal cord where it modulates pain, motor activity (Koblinger et al., 2014), and somatosensory processing (Zhang et a., 2023)." . [] oboInOwl:hasDbXref "PMID:39919032" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4072009 ; owl:annotatedTarget "A type of dopaminergic neuron found in the arcuate hypothalamic nucleus, involved in neuroendocrine regulation, metabolic homeostasis and prolactin secretion." . [] oboInOwl:hasDbXref "GO:0051458" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000467 ; owl:annotatedTarget "corticotropin secreting cell" . [] oboInOwl:hasDbXref "PMID:39919032" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4072009 ; owl:annotatedTarget "hypothalamic arcuate nucleus dopaminergic neuron" . [] oboInOwl:hasDbXref "PMID:33318433", "PMID:37816347" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4072010 ; owl:annotatedTarget "A type of dopaminergic neuron located in the rostro-medial part of the zona incerta. It is involved in nociception and prehensile movement." . [] oboInOwl:hasDbXref "PMID:10465451", "PMID:19210380", "PMID:33257725", "PMID:36209152" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4072011 ; owl:annotatedTarget "A type of dopaminergic neuron located in the periventricular nucleus of the hypothalamus and projecting to the lateral septum and the median eminence. It is contributing to neuroendocrine functions, locomotion and stress regulation." . [] oboInOwl:hasDbXref "PMID:26132331", "PMID:36209152" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4072012 ; owl:annotatedTarget "A type of dopaminergic neuron located in the preoptic periventricular nucleus of the hypothalamus and implicated in neuroendocrine modulation." . [] oboInOwl:hasDbXref "PMID:28261065", "doi:/10.1101/2023.08.29.554772" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4072013 ; owl:annotatedTarget "A type of dopaminergic interneuron located in the glomerular layer of the main olfactory bulb, characterized by the co-release of dopamine and GABA, and involved in modulating sensory input within olfactory circuits." . [] oboInOwl:hasDbXref "PMID:23649873", "PMID:26017494" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4072014 ; owl:annotatedTarget "A specialized, non-ciliated ependymal glial cell located in the ventricular wall of the organum vasculosum of the lamina terminalis (OVLT) and characterized by elongated basal processes extending into the parenchyma to contact fenestrated capillaries. In mice, it is characterised by the expression of tight junction proteins (claudin 1, occludin, ZO-1) forming a continuous honeycomb junctional pattern. This cell contributes to a functional blood–cerebrospinal fluid (CSF) barrier at the ventricular interface of the OVLT." . [] oboInOwl:hasDbXref "PMID:23649873" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4072014 ; owl:annotatedTarget "Tanycyte-like cells in CVOs" . [] oboInOwl:hasDbXref "PMID:32071335" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4072014 ; owl:annotatedTarget "tanycyte-like cell of OVLT" . [] oboInOwl:hasDbXref "PMID:32071335" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4072014 ; owl:annotatedTarget "tanycyte-like ependymal cell of OVLT" . [] oboInOwl:hasDbXref "PMID:26813785", "PMID:31561945", "PMID:37740916" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4072015 ; owl:annotatedTarget "A Kupffer cell located within the hepatic sinusoids, derived from circulating bone marrow monocytes that acquire the phenotypic markers and functional properties of resident Kupffer cells through niche-dependent imprinting, typically following depletion of the embryonically derived Kupffer cell population. During liver injury, MoKCs become the dominant Kupffer cell subset, exhibiting enhanced proliferation, resistance to apoptosis, and key roles in tissue repair and fibrosis attenuation." . [] oboInOwl:hasDbXref "PMID:37740916" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4072015 ; owl:annotatedTarget "MoKC" . [] oboInOwl:hasDbXref "doi:10.1002/glia.21162" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000468 ; owl:annotatedTarget "A precursor of the central nervous system that gives rise to both neurons and glial cells." . [] oboInOwl:hasDbXref "PMID:35803588" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4072102 ; owl:annotatedTarget "A type of GABAergic interneuron residing in the Purkinje cell layer of the cerebellar cortex." . [] oboInOwl:hasDbXref "PMID:35803588" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4072102 ; owl:annotatedTarget "PLI" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000468 ; owl:annotatedTarget "FBbt:00005147" ; sssom:mapping_justification . [] obo:STATO_0000663 "0.62880975"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300028 ; owl:annotatedTarget obo:CLM_5007648 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300028 ; owl:annotatedTarget "A cerebellar neuron of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:28 CB GABA." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300028 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkZTMDBEWFYwVDlSMVg5Rko0UUUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300028 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] obo:STATO_0000663 "0.7043236"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300029 ; owl:annotatedTarget obo:CLM_5007649 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300029 ; owl:annotatedTarget "A cerebellum glutamatergic neuron of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:29 CB Glut." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300029 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkZTMDBEWFYwVDlSMVg5Rko0UUUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_29" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300029 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_29.h5ad" . [] oboInOwl:hasDbXref "PMID:19243617" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource cl:has_low_plasma_membrane_amount ; owl:annotatedTarget "OBSOLETE A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617)." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000469 ; owl:annotatedTarget "FBbt:00005149" ; sssom:mapping_justification . [] obo:STATO_0000663 "0.8972486"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300031 ; owl:annotatedTarget obo:CLM_5007651 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300031 ; owl:annotatedTarget "A cell of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:31 OPC-Oligo." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300031 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIBMzEgT1BDLU9saWdvAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300031 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000470 ; owl:annotatedTarget "ZFA:0009217" ; sssom:mapping_justification . [] obo:STATO_0000663 "0.70412517"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300101 ; owl:annotatedTarget obo:CLM_5000101 . [] obo:STATO_0000663 "0.71593535"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300101 ; owl:annotatedTarget obo:CLM_5007721 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300101 ; owl:annotatedTarget "A direct pathway medium spiny neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Prkch (Mmus), Slc32a1 (Mmus), Drd1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:061 STR D1 Gaba." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300101 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMDYxIFNUUiBEMSBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_09" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300101 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_09.h5ad" . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000472 ; owl:annotatedTarget "Obsolete. Use PO:0000076 from Plant Ontology instead. OBSOLETE, use term from Plant Ontology. Parenchyma cells containing chloroplasts; a component of leaf mesophyll and other green parenchyma tissue." . [] obo:STATO_0000663 "0.6617923"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300102 ; owl:annotatedTarget obo:CLM_5000102 . [] obo:STATO_0000663 "0.8310593"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300102 ; owl:annotatedTarget obo:CLM_5007722 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300102 ; owl:annotatedTarget "A indirect pathway medium spiny neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Adora2a (Mmus), Phactr1 (Mmus), Pcp4l1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:062 STR D2 Gaba." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300102 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMDYyIFNUUiBEMiBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgEwNjIgU1RSIEQyIEdhYmEAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_09" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300102 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_09.h5ad" . [] oboInOwl:hasDbXref "FBbt:00003184", "GO:0061320", "GOC:tfm", "PMID:19783135" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000474 ; owl:annotatedTarget "An insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel." . [] obo:STATO_0000663 "0.49118388"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300348 ; owl:annotatedTarget obo:CLM_5000348 . [] obo:STATO_0000663 "0.5344828"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300348 ; owl:annotatedTarget obo:CLM_5007968 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300348 ; owl:annotatedTarget "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Tmem204 (Mmus), Slc6a5 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:308 DCO Il22 Gly-Gaba." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300348 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzA4IERDTyBJbDIyIEdseS1HYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300348 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000474 ; owl:annotatedTarget "FBbt:00005058" ; sssom:mapping_justification . [] obo:STATO_0000663 "0.023094688"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300349 ; owl:annotatedTarget obo:CLM_5000349 . [] obo:STATO_0000663 "0.56375134"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300349 ; owl:annotatedTarget obo:CLM_5007969 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300349 ; owl:annotatedTarget "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Rgs6 (Mmus), Slc6a5 (Mmus), Shisa9 (Mmus), Zic1 (Mmus), Bmp6 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:309 CB PLI Gly-Gaba." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300349 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300349 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] oboInOwl:hasDbXref "FBbt:00005058", "GO:0061320" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_0000474 ; owl:annotatedTarget "pericardial cell" . [] obo:STATO_0000663 "0.24193548"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300351 ; owl:annotatedTarget obo:CLM_5000351 . [] obo:STATO_0000663 "0.6644144"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300351 ; owl:annotatedTarget obo:CLM_5007971 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300351 ; owl:annotatedTarget "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Homer3 (Mmus), Tfap2b (Mmus), Sorcs3 (Mmus), Cacna1e (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:311 CBX MLI Megf11 Gaba." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300351 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzExIENCWCBNTEkgTWVnZjExIEdhYmEAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMxMSBDQlggTUxJIE1lZ2YxMSBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300351 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] oboInOwl:hasDbXref "TAIR:lr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000475 ; owl:annotatedTarget "Obsolete. Use PO:0000245 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that do not participate in megagametogenesis." . [] obo:STATO_0000663 "0.9569378"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300353 ; owl:annotatedTarget obo:CLM_5000353 . [] obo:STATO_0000663 "0.99375"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300353 ; owl:annotatedTarget obo:CLM_5007973 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300353 ; owl:annotatedTarget "A Purkinje cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pcp2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:313 CBX Purkinje Gaba." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300353 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzEzIENCWCBQdXJraW5qZSBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300353 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] obo:STATO_0000663 "0.62749004"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300354 ; owl:annotatedTarget obo:CLM_5000354 . [] obo:STATO_0000663 "0.8494624"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300354 ; owl:annotatedTarget obo:CLM_5007974 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300354 ; owl:annotatedTarget "A cerebellar granule cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Ror1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:314 CB Granule Glut." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300354 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_29" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300354 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_29.h5ad" . [] oboInOwl:hasDbXref "ISBN:0517223651", "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000476 ; owl:annotatedTarget "A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center." . [] obo:STATO_0000663 "0.4052198"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300358 ; owl:annotatedTarget obo:CLM_5000358 . [] obo:STATO_0000663 "0.6994048"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300358 ; owl:annotatedTarget obo:CLM_5007978 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300358 ; owl:annotatedTarget "A transcriptomically defined type of astrocyte located predominantly in the ventral and posterior subcortical areas. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Cd38 (Mmus), Agt (Mmus), Itih3 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:318 Astro-NT NN." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300358 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE4IEFzdHJvLU5UIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300358 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000476 ; owl:annotatedTarget "ZFA:0009218" ; sssom:mapping_justification . [] obo:STATO_0000663 "0.03968254"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300359 ; owl:annotatedTarget obo:CLM_5000359 . [] obo:STATO_0000663 "0.58093345"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300359 ; owl:annotatedTarget obo:CLM_5007979 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300359 ; owl:annotatedTarget "A transcritpomically defined type of astrocytes primarily restricted to the dorsal regions of the cerebrum. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Lhx2 (Mmus), Gpc5 (Mmus), Nr2f1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:319 Astro-TE NN." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300359 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE5IEFzdHJvLVRFIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300359 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:STATO_0000663 "0.67099565"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300360 ; owl:annotatedTarget obo:CLM_5000360 . [] obo:STATO_0000663 "0.6818182"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300360 ; owl:annotatedTarget obo:CLM_5007980 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300360 ; owl:annotatedTarget "A transcriptomically defined type of astrocyte located exclusively in the olfactory areas. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Hs3st3a1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:320 Astro-OLF NN." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300360 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300360 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:STATO_0000663 "0.74880874"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300362 ; owl:annotatedTarget obo:CLM_5000362 . [] obo:STATO_0000663 "0.77756834"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300362 ; owl:annotatedTarget obo:CLM_5007982 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300362 ; owl:annotatedTarget "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr50 (Mmus), Apoe (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:322 Tanycyte NN." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300362 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzIyIFRhbnljeXRlIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300362 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] oboInOwl:source ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000477 ; owl:annotatedTarget _:genid1778 . [] obo:STATO_0000663 "0.9508816"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300363 ; owl:annotatedTarget obo:CLM_5000363 . [] obo:STATO_0000663 "0.97694635"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300363 ; owl:annotatedTarget obo:CLM_5007983 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300363 ; owl:annotatedTarget "A ependymal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Tmem212 (Mmus), Rarres2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:323 Ependymal NN." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300363 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300363 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000477 ; owl:annotatedTarget "FBbt:00004904" ; sssom:mapping_justification . [] obo:STATO_0000663 "0.7124217"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300366 ; owl:annotatedTarget obo:CLM_5000366 . [] obo:STATO_0000663 "0.9503155"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300366 ; owl:annotatedTarget obo:CLM_5007986 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300366 ; owl:annotatedTarget "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:326 OPC NN." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300366 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300366 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] oboInOwl:hasDbXref "GO:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000478 ; owl:annotatedTarget "A peptide hormone secreting cell that secretes oxytocin stimulating hormone" . [] obo:STATO_0000663 "0.9230531"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300367 ; owl:annotatedTarget obo:CLM_5000367 . [] obo:STATO_0000663 "0.9235276"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300367 ; owl:annotatedTarget obo:CLM_5007987 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300367 ; owl:annotatedTarget "A oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), Gjc3 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:327 Oligo NN." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300367 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzI3IE9saWdvIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300367 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] oboInOwl:hasDbXref "GO:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000479 ; owl:annotatedTarget "A peptide hormone secreting cell that secretes vasopressin stimulating hormone" . [] obo:STATO_0000663 "0.8806818"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300370 ; owl:annotatedTarget obo:CLM_5000370 . [] obo:STATO_0000663 "0.8556548"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4300370 ; owl:annotatedTarget obo:CLM_5007990 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4300370 ; owl:annotatedTarget "A vascular leptomeningeal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Slc6a13 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:330 VLMC NN." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300370 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzMwIFZMTUMgTk4AAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMzMCBWTE1DIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_33" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4300370 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_33.h5ad" . [] oboInOwl:hasDbXref "GO:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000480 ; owl:annotatedTarget "A peptide hormone secreting cell that secretes secretin stimulating hormone" . [] obo:STATO_0000663 "0.2741228"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301571 ; owl:annotatedTarget obo:CLM_5001561 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301571 ; owl:annotatedTarget "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Il22 (Mmus), Rftn1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1141 DCO Il22 Gly-Gaba_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301571 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0MSBEQ08gSWwyMiBHbHktR2FiYV8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301571 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] oboInOwl:hasDbXref "GO:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000481 ; owl:annotatedTarget "A peptide hormone secreting cell that secretes cholecystokin stimulating hormone." . [] obo:STATO_0000663 "0.4560811"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301573 ; owl:annotatedTarget obo:CLM_5001563 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301573 ; owl:annotatedTarget "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Fat2 (Mmus), Slc6a5 (Mmus), Cgnl1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1143 DCO Il22 Gly-Gaba_3." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301573 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0MyBEQ08gSWwyMiBHbHktR2FiYV8zAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301573 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] obo:STATO_0000663 "0.49407116"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301574 ; owl:annotatedTarget obo:CLM_5001564 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301574 ; owl:annotatedTarget "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Hmga2 (Mmus), Afap1l2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1144 CB PLI Gly-Gaba_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301574 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301574 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] obo:STATO_0000663 "0.74850297"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301575 ; owl:annotatedTarget obo:CLM_5001565 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301575 ; owl:annotatedTarget "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pthlh (Mmus), Tfap2b (Mmus), Rspo2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1145 CB PLI Gly-Gaba_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301575 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301575 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] obo:STATO_0000663 "0.30487806"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301576 ; owl:annotatedTarget obo:CLM_5001566 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301576 ; owl:annotatedTarget "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pax2 (Mmus), C1ql3 (Mmus), Tfap2b (Mmus), Gabrb1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1146 CB PLI Gly-Gaba_3." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301576 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301576 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] obo:STATO_0000663 "0.610687"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301578 ; owl:annotatedTarget obo:CLM_5001568 . [] obo:STATO_0000663 "0.87349397"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301578 ; owl:annotatedTarget obo:CLM_5007970 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301578 ; owl:annotatedTarget "A cerebellar Golgi cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Zfp385c (Mmus), Tfap2b (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1148 CBX Golgi Gly-Gaba_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301578 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301578 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] obo:STATO_0000663 "0.3030303"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301579 ; owl:annotatedTarget obo:CLM_5001569 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301579 ; owl:annotatedTarget "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dnah11 (Mmus), Sla (Mmus), Gldc (Mmus), Sdk2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1149 CBX MLI Megf11 Gaba_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301579 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0OSBDQlggTUxJIE1lZ2YxMSBHYWJhXzEAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExNDkgQ0JYIE1MSSBNZWdmMTEgR2FiYV8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301579 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] obo:STATO_0000663 "0.7986111"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301580 ; owl:annotatedTarget obo:CLM_5001570 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301580 ; owl:annotatedTarget "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Pvalb (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1150 CBX MLI Megf11 Gaba_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301580 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1MCBDQlggTUxJIE1lZ2YxMSBHYWJhXzIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExNTAgQ0JYIE1MSSBNZWdmMTEgR2FiYV8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301580 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] oboInOwl:hasDbXref "GO:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000482 ; owl:annotatedTarget "An endocrine cell that secretes juvenile hormone." . [] obo:STATO_0000663 "0.608828"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301582 ; owl:annotatedTarget obo:CLM_5001572 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301582 ; owl:annotatedTarget "A Purkinje cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pcp2 (Mmus), Stk17b (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1152 CBX Purkinje Gaba_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301582 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1MiBDQlggUHVya2luamUgR2FiYV8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301582 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000482 ; owl:annotatedTarget "FBbt:00058020" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301583 ; owl:annotatedTarget "A Purkinje cell of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1153 CBX Purkinje Gaba_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301583 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1MyBDQlggUHVya2luamUgR2FiYV8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301583 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] oboInOwl:hasDbXref "GO:tfm", "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000483 ; owl:annotatedTarget "A peptide hormone secreting cell that secretes bombesin stimulating hormone." . [] obo:STATO_0000663 "0.35714287"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301584 ; owl:annotatedTarget obo:CLM_5001574 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301584 ; owl:annotatedTarget "A cerebellar granule cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Lmx1a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1154 CB Granule Glut_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301584 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_29" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301584 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_29.h5ad" . [] obo:STATO_0000663 "0.24193548"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301585 ; owl:annotatedTarget obo:CLM_5001575 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301585 ; owl:annotatedTarget "A cerebellar granule cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Gap43 (Mmus), Rab37 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1155 CB Granule Glut_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301585 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_29" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301585 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_29.h5ad" . [] obo:STATO_0000663 "0.5875"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301586 ; owl:annotatedTarget obo:CLM_5001576 . [] obo:STATO_0000663 "0.875"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301586 ; owl:annotatedTarget obo:CLM_5007975 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301586 ; owl:annotatedTarget "A unipolar brush cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Sln (Mmus), Lmx1a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1156 DCO UBC Glut_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301586 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_29" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301586 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_29.h5ad" . [] obo:STATO_0000663 "0.14610389"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301589 ; owl:annotatedTarget obo:CLM_5001579 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301589 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Lhfpl3 (Mmus), Gria1 (Mmus), Hopx (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1159 Astro-NT NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301589 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1OSBBc3Ryby1OVCBOTl8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301589 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:STATO_0000663 "0.3472222"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301590 ; owl:annotatedTarget obo:CLM_5001580 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301590 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Itih3 (Mmus), Gria2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1160 Astro-NT NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301590 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MCBBc3Ryby1OVCBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301590 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:STATO_0000663 "0.19067797"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301591 ; owl:annotatedTarget obo:CLM_5001581 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301591 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Camk2a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1161 Astro-TE NN_1." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000484 ; owl:annotatedTarget obo:CL_0000097 . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301591 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MSBBc3Ryby1URSBOTl8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301591 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:STATO_0000663 "0.5882353"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301592 ; owl:annotatedTarget obo:CLM_5001582 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301592 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Hepacam (Mmus), E330013P04Rik (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1162 Astro-TE NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301592 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MiBBc3Ryby1URSBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "PMID:19923473", "PMID:9354811" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000484 ; owl:annotatedTarget "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent." . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301592 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:STATO_0000663 "0.33450705"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301593 ; owl:annotatedTarget obo:CLM_5001583 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301593 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Grin2c (Mmus), Dcc (Mmus), Slc7a10 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1163 Astro-TE NN_3." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301593 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MyBBc3Ryby1URSBOTl8zAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgExMTYzIEFzdHJvLVRFIE5OXzMAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301593 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:STATO_0000663 "0.048076924"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301595 ; owl:annotatedTarget obo:CLM_5001585 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301595 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Thbs4 (Mmus), Kcnk10 (Mmus), Pak1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1165 Astro-TE NN_5." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301595 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2NSBBc3Ryby1URSBOTl81AAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301595 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:STATO_0000663 "0.5113636"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301596 ; owl:annotatedTarget obo:CLM_5001586 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301596 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Prss23 (Mmus), Igfbp2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1166 Astro-OLF NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301596 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301596 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:STATO_0000663 "0.37280703"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301597 ; owl:annotatedTarget obo:CLM_5001587 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301597 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Hs3st3a1 (Mmus), Slco1c1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1167 Astro-OLF NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301597 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2NyBBc3Ryby1PTEYgTk5fMgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2NyBBc3Ryby1PTEYgTk5fMgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301597 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:STATO_0000663 "0.1724138"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301598 ; owl:annotatedTarget obo:CLM_5001588 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301598 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ednrb (Mmus), Hs3st3a1 (Mmus), C230072F16Rik (Mmus), Gria2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1168 Astro-OLF NN_3." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301598 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301598 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:STATO_0000663 "0.390625"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301602 ; owl:annotatedTarget obo:CLM_5001592 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301602 ; owl:annotatedTarget "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cnmd (Mmus), Lpl (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1172 Tanycyte NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301602 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE3MiBUYW55Y3l0ZSBOTl8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301602 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:STATO_0000663 "0.54086536"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301603 ; owl:annotatedTarget obo:CLM_5001593 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301603 ; owl:annotatedTarget "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr50 (Mmus), Ccdc170 (Mmus), Nkx2-4 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1173 Tanycyte NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301603 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE3MyBUYW55Y3l0ZSBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301603 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:STATO_0000663 "0.99385244"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301608 ; owl:annotatedTarget obo:CLM_5001598 . [] obo:STATO_0000663 "0.9857724"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301608 ; owl:annotatedTarget obo:CLM_5007985 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301608 ; owl:annotatedTarget "A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1178 CHOR NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301608 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzI1IENIT1IgTk4AAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMyNSBDSE9SIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301608 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:STATO_0000663 "0.8684739"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301611 ; owl:annotatedTarget obo:CLM_5001601 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z", "https://doi.org/10.1126/science.aaf6463" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301611 ; owl:annotatedTarget "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bmp4 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1181 COP NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301611 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301611 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:STATO_0000663 "0.6304985"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301612 ; owl:annotatedTarget obo:CLM_5001602 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z", "https://doi.org/10.1126/science.aaf6463" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301612 ; owl:annotatedTarget "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Ptprb (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1182 NFOL NN_2." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000485 ; owl:annotatedTarget obo:CL_0000097 . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301612 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE4MiBORk9MIE5OXzIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExODIgTkZPTCBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301612 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:STATO_0000663 "0.49418604"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301613 ; owl:annotatedTarget obo:CLM_5001603 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z", "https://doi.org/10.1126/science.aaf6463" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301613 ; owl:annotatedTarget "A myelin-forming oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), Sec14l5 (Mmus), 9630013A20Rik (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1183 MFOL NN_3." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301613 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE4MyBNRk9MIE5OXzMAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExODMgTUZPTCBOTl8zAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "PMID:19923473", "PMID:9354811" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000485 ; owl:annotatedTarget "Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype." . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301613 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:STATO_0000663 "0.7853026"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301614 ; owl:annotatedTarget obo:CLM_5001604 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z", "https://doi.org/10.1126/science.aaf6463" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301614 ; owl:annotatedTarget "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), Anln (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1184 MOL NN_4." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301614 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301614 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19783135", "fbbt:00005059" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000486 ; owl:annotatedTarget "A large binucleate cell that forms a 'garland' around the anterior end of the proventriculus (cardia) at its junction with the esophagus in both adults and larvae flies. Each cell is surrounded by a basement membrane and there are numerous micro-invaginations (lacunae) extending from the surface into the cytoplasm. At the mouth of each lacuna is a doubled filament forming a specialised filtration system (diaphragm). The filtrate is endocytosed from the lacunae." . [] obo:STATO_0000663 "0.8990148"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301615 ; owl:annotatedTarget obo:CLM_5007652 . [] obo:STATO_0000663 "0.9126984"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301615 ; owl:annotatedTarget obo:CLM_5007988 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301615 ; owl:annotatedTarget "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Npy (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1185 OEC NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301615 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIBMzIgT0VDAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECRlMwMERYVjBUOVIxWDlGSjRRRQADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgEzMiBPRUMAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQJGUzAwRFhWMFQ5UjFYOUZKNFFFAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] oboInOwl:hasDbXref "GO:0061321" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000486 ; owl:annotatedTarget "garland nephrocyte" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_32" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301615 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_32.h5ad" . [] obo:STATO_0000663 "0.8968254"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301616 ; owl:annotatedTarget obo:CLM_5001606 . [] obo:STATO_0000663 "0.93650794"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301616 ; owl:annotatedTarget obo:CLM_5007989 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301616 ; owl:annotatedTarget "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Thbd (Mmus), Ccn3 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1186 ABC NN_1." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000486 ; owl:annotatedTarget "FBbt:00005059" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301616 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_33" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301616 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_33.h5ad" . [] obo:STATO_0000663 "0.9244792"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301625 ; owl:annotatedTarget obo:CLM_5001615 . [] obo:STATO_0000663 "0.982906"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4301625 ; owl:annotatedTarget obo:CLM_5007995 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4301625 ; owl:annotatedTarget "A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Maf (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1195 BAM NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301625 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_34" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4301625 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_34.h5ad" . [] oboInOwl:evidence , , ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_4304384 ; owl:annotatedTarget obo:CL_0011111 . [] oboInOwl:hasDbXref "GOC:bf", "PMID:11171397", "PMID:24397521", "PMID:34208190", "https://www.merriam-webster.com/dictionary/oenocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000487 ; owl:annotatedTarget "A secretory cell of ectodermal origin. This cell may have important functions in fatty acid and hydrocarbon metabolism and is metabolically linked to the fat body and tracheae. This cell is exclusive of arthropods." . [] obo:CLM_0010002 "0.22" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4304384 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4304384 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.25" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4304384 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.15" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4304384 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.11" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4304384 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.42" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4304384 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.14" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4304384 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.9917355"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4304384 ; owl:annotatedTarget obo:CLM_5007635 . [] obo:STATO_0000663 "0.9917355"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4304384 ; owl:annotatedTarget obo:CLM_5007802 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4304384 ; owl:annotatedTarget "A hypothalamic gonadotropin-releasing hormone neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gnrh1 (Mmus). It is glutamatergic. These cells are located in the Hypothalamus, Olfactory areas, Pallidum, brain , in or close to the regions: Lateral septal nucleus, rostral (rostroventral) part, Medial septal nucleus, Diagonal band nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:2564 HY Gnrh1 Glut_1." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000487 ; owl:annotatedTarget "FBbt:00004995" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4304384 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkZTMDBEWFYwVDlSMVg5Rko0UUUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_15" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4304384 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_15.h5ad" . [] oboInOwl:evidence , , ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_4306426 ; owl:annotatedTarget obo:CL_0000652 . [] a owl:Axiom ; rdfs:comment "Inferred to be glutamate secretion, neurotransmission based on expression of Ddc, Slc17a6, Slc17a7" ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_4306426 ; owl:annotatedTarget _:genid17936 . [] oboInOwl:hasDbXref "PMID:24397521", "PMID:34208190" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0000487 ; owl:annotatedTarget "Oenocytes are highly variable in size, shape, cluster formation and anatomical location. In adults, oenocytes tend to be smaller but more numerous than in larvae. While oenocytes have been found in arachnids and crustaceans, they have been most abundantly described in insects." . [] obo:CLM_0010002 "0.38" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4306426 ; owl:annotatedTarget . [] obo:CLM_0010002 "1.0" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4306426 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.9782609"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4306426 ; owl:annotatedTarget obo:CLM_5007645 . [] obo:STATO_0000663 "0.9782609"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4306426 ; owl:annotatedTarget obo:CLM_5007922 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z", "https://doi.org/10.1111/j.1600-079x.1996.tb00284.x", "https://doi.org/10.3389/fendo.2019.00590" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4306426 ; owl:annotatedTarget "A pinealocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cngb3 (Mmus), Ush2a (Mmus). It is glutamatergic. These cells are located in the brain , in or close to the regions: third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:4606 Pineal Crx Glut_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4306426 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIBMjUgUGluZWFsIEdsdXQAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJGUzAwRFhWMFQ5UjFYOUZKNFFFAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACATI1IFBpbmVhbCBHbHV0AAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECRlMwMERYVjBUOVIxWDlGSjRRRQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_25" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4306426 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_25.h5ad" . [] obo:CLM_0010002 "0.2" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4306992 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.44" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4306992 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.25" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4306992 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.16" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4306992 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.44" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4306992 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.31" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4306992 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.8910891"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4306992 ; owl:annotatedTarget obo:CLM_5006922 . [] obo:STATO_0000663 "0.9292035"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4306992 ; owl:annotatedTarget obo:CLM_5022142 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4306992 ; owl:annotatedTarget "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Il22 (Mmus), Edaradd (Mmus). It is distinguished from other DCO Il22 Gly-Gaba cells by expression of Ppp1r17. It is GABAergic and glycinergic. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Paraflocculus, arbor vitae, Dorsal cochlear nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5172 DCO Il22 Gly-Gaba_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4306992 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTE3MiBEQ08gSWwyMiBHbHktR2FiYV8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4306992 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] obo:CLM_0010002 "0.76" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307005 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.14" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307005 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.11" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307005 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.17" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307005 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.2" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307005 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.8"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307005 ; owl:annotatedTarget obo:CLM_5006935 . [] obo:STATO_0000663 "0.9459459"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307005 ; owl:annotatedTarget obo:CLM_5022155 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307005 ; owl:annotatedTarget "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ly6d (Mmus), Kit (Mmus). It is distinguished from other CB PLI Gly-Gaba cells by expression of Ly6d. It is GABAergic. These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae, Interposed nucleus, Nodulus (X) . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5185 CB PLI Gly-Gaba_4." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307005 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307005 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] oboInOwl:evidence , , ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_4307012 ; owl:annotatedTarget obo:CL_4042035 . [] obo:CLM_0010002 "0.69" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307012 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.31" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307012 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.1724138"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307012 ; owl:annotatedTarget obo:CLM_5006942 . [] obo:STATO_0000663 "0.5508475"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307012 ; owl:annotatedTarget obo:CLM_5007972 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307012 ; owl:annotatedTarget "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cdh1 (Mmus), Acvr1c (Mmus), Adamts15 (Mmus), Pax2 (Mmus). It is distinguished from other CB GABA cells by expression of Cdh1, Acvr1c, Adamts15, Pax2. It is GABAergic. These cells are located in the Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5192 CBX MLI Cdh22 Gaba_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307012 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_28" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307012 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" . [] oboInOwl:evidence ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_4307026 ; owl:annotatedTarget obo:CL_0000644 . [] obo:CLM_0010002 "0.73" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307026 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.27" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307026 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.6818182"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307026 ; owl:annotatedTarget obo:CLM_5006956 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000488 ; owl:annotatedTarget "A photoreceptor cell that detects visible light." . [] obo:STATO_0000663 "0.8908046"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307026 ; owl:annotatedTarget obo:CLM_5007976 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307026 ; owl:annotatedTarget "A Bergmann glial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr37l1 (Mmus), Ctxn3 (Mmus). It is distinguished from other Astro-Epen cells by expression of Gpr37l1, Ctxn3. These cells are located in the Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5206 Bergmann NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307026 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIwNiBCZXJnbWFubiBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307026 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] oboInOwl:evidence ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_4307027 ; owl:annotatedTarget obo:CL_0002603 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000488 ; owl:annotatedTarget "ZFA:0009219" ; sssom:mapping_justification . [] obo:CLM_0010002 "0.65" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307027 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.14" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307027 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.34" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307027 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.4054054"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307027 ; owl:annotatedTarget obo:CLM_5006957 . [] obo:STATO_0000663 "0.6849315"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307027 ; owl:annotatedTarget obo:CLM_5007977 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307027 ; owl:annotatedTarget "A transcriptomically defined type of astrocyte localized exclusively in the cerebellum beneath the Purkinje cell layer. It is distinguished from other cells in the brain by selective expression of Dao (Mmus), Efemp1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5207 Astro-CB NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307027 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIwNyBBc3Ryby1DQiBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307027 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000490 ; owl:annotatedTarget "ZFA:0009220" ; sssom:mapping_justification . [] obo:CLM_0010002 "0.32" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307028 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.15" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307028 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.57" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307028 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.3030303"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307028 ; owl:annotatedTarget obo:CLM_5006958 . [] obo:STATO_0000663 "0.74"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307028 ; owl:annotatedTarget obo:CLM_5022178 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307028 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Galnt15 (Mmus), Agt (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Galnt15. These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5208 Astro-NT NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307028 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIwOCBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307028 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.12" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307029 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307029 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.56" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307029 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.35714287"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307029 ; owl:annotatedTarget obo:CLM_5006959 . [] obo:STATO_0000663 "0.4878049"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307029 ; owl:annotatedTarget obo:CLM_5022179 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307029 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Slc36a2 (Mmus), Sfrp5 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Slc36a2, Sfrp5. These cells are located in the Midbrain, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5209 Astro-NT NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307029 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIwOSBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307029 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.26" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307030 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.16" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307030 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.51" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307030 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.27027026"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307030 ; owl:annotatedTarget obo:CLM_5006960 . [] obo:STATO_0000663 "0.4918033"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307030 ; owl:annotatedTarget obo:CLM_5022180 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307030 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Sfrp5 (Mmus), Cldn10 (Mmus), Riiad1 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Nuf2, Shroom3. These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5210 Astro-NT NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307030 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxMCBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307030 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.12" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307031 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307031 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.14" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307031 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.48" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307031 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.3030303"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307031 ; owl:annotatedTarget obo:CLM_5006961 . [] obo:STATO_0000663 "0.6097561"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307031 ; owl:annotatedTarget obo:CLM_5022181 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307031 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Six3os1 (Mmus), Slc36a2 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Six3os1. These cells are located in the Striatum-like amygdalar nuclei, Olfactory areas, brain , in or close to the regions: Medial amygdalar nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5211 Astro-NT NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307031 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxMSBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307031 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307032 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.21" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307032 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.2" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307032 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.58" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307032 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.16129032"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307032 ; owl:annotatedTarget obo:CLM_5006962 . [] obo:STATO_0000663 "0.16129032"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307032 ; owl:annotatedTarget obo:CLM_5022182 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307032 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Agt (Mmus), Prss35 (Mmus), C4b (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Kcnk10, C4b. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5212 Astro-NT NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307032 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxMiBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307032 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.35" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307033 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307033 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.18" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307033 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.5" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307033 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.3" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307033 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.14" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307033 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.2" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307033 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.5882353"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307033 ; owl:annotatedTarget obo:CLM_5006963 . [] obo:STATO_0000663 "0.5"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307033 ; owl:annotatedTarget obo:CLM_5022183 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307033 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dao (Mmus), Mecom (Mmus), Fbln5 (Mmus), Prelp (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Mecom, Prelp. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Ventral cochlear nucleus, Paraflocculus, Flocculus, Dorsal cochlear nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5213 Astro-NT NN_1." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000492 ; owl:annotatedTarget obo:CL_0000624 . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307033 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxMyBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307033 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307034 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.56" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307034 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.11" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307034 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "MESH:D006377" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000492 ; owl:annotatedTarget "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307034 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.2631579"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307034 ; owl:annotatedTarget obo:CLM_5006964 . [] obo:STATO_0000663 "0.3030303"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307034 ; owl:annotatedTarget obo:CLM_5022184 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307034 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Sfrp5 (Mmus), Gria2 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Fzd2, Gria2, Ttll3. These cells are located in the Midbrain, Thalamus, Pons , in or close to the regions: Midbrain reticular nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5214 Astro-NT NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307034 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNCBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307034 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.14" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307035 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.91" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307035 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.17" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307035 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.24193548"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307035 ; owl:annotatedTarget obo:CLM_5006965 . [] obo:STATO_0000663 "0.44871795"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307035 ; owl:annotatedTarget obo:CLM_5022185 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307035 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Otx2 (Mmus), Unc13c (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Sez6l, Unc13c. These cells are located in the Thalamus , in or close to the regions: Posterior complex of the thalamus, Ventral posteromedial nucleus of the thalamus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5215 Astro-NT NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307035 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNSBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307035 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.19" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307036 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.35" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307036 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.27" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307036 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.1724138"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307036 ; owl:annotatedTarget obo:CLM_5006966 . [] obo:STATO_0000663 "0.2857143"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307036 ; owl:annotatedTarget obo:CLM_5022186 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307036 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc7a10 (Mmus), Cyp26b1 (Mmus), Igfbp2 (Mmus), Shroom3 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Fam227b, Shroom3. These cells are located in the Midbrain, Medulla, Pons . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5216 Astro-NT NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307036 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNiBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307036 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307037 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.33" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307037 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.26" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307037 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.11" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307037 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.22" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307037 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.09259259"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307037 ; owl:annotatedTarget obo:CLM_5006967 . [] obo:STATO_0000663 "0.5555556"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307037 ; owl:annotatedTarget obo:CLM_5022187 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307037 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), A330076C08Rik (Mmus), Fbln5 (Mmus), Mdga2 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Gm30524. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Ventral cochlear nucleus, arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5217 Astro-NT NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307037 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNyBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307037 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.23" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307038 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.15" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307038 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.55" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307038 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.1724138"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307038 ; owl:annotatedTarget obo:CLM_5006968 . [] obo:STATO_0000663 "0.3030303"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307038 ; owl:annotatedTarget obo:CLM_5022188 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307038 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Lhx2 (Mmus), Kcne1l (Mmus), Alpk1 (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Kcne1l, Alpk1. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5218 Astro-TE NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307038 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxOCBBc3Ryby1URSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307038 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000494 ; owl:annotatedTarget "A photoreceptor cell that detects ultraviolet light." . [] obo:CLM_0010002 "0.15" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307039 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.2" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307039 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.42" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307039 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.09259259"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307039 ; owl:annotatedTarget obo:CLM_5006969 . [] obo:STATO_0000663 "0.48319328"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307039 ; owl:annotatedTarget obo:CLM_5022189 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000494 ; owl:annotatedTarget "ZFA:0009221" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307039 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Ddn (Mmus), Myoc (Mmus), Rasl10b (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Rasl10b, Igfbp5. These cells are located in the Hippocampal region, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5219 Astro-TE NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307039 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxOSBBc3Ryby1URSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307039 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.67" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307040 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.20588236"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307040 ; owl:annotatedTarget obo:CLM_5006970 . [] oboInOwl:hasDbXref "GO:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000495 ; owl:annotatedTarget "A photoreceptor cell that is sensitive to blue light." . [] obo:STATO_0000663 "0.1724138"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307040 ; owl:annotatedTarget obo:CLM_5022190 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307040 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Dio2 (Mmus), Lncpint (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Lncpint. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5220 Astro-TE NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307040 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyMCBBc3Ryby1URSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307040 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] a owl:Axiom ; rdfs:comment "Inferred to be glutamate secretion, neurotransmission based on expression of Aldh1a1, Slc17a7" ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_4307041 ; owl:annotatedTarget _:genid18197 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000495 ; owl:annotatedTarget "ZFA:0009222" ; sssom:mapping_justification . [] obo:CLM_0010002 "0.19" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307041 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.76" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307041 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.26595744"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307041 ; owl:annotatedTarget obo:CLM_5006971 . [] obo:STATO_0000663 "0.5797101"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307041 ; owl:annotatedTarget obo:CLM_5022191 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307041 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Sptbn2 (Mmus), Alpk1 (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Jph4, Alpk1. It is glutamatergic. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5221 Astro-TE NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307041 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyMSBBc3Ryby1URSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307041 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] oboInOwl:hasDbXref "GO:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000496 ; owl:annotatedTarget "A photoreceptor cell that is sensitive to green light." . [] obo:CLM_0010002 "0.19" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307042 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.19" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307042 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.97" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307042 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307042 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.27" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307042 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.39215687"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307042 ; owl:annotatedTarget obo:CLM_5006972 . [] obo:STATO_0000663 "0.7758621"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307042 ; owl:annotatedTarget obo:CLM_5022192 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307042 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gm6145 (Mmus), E330013P04Rik (Mmus), Slc39a12 (Mmus). It is distinguished from other Astro-TE NN_2 cells by expression of Clstn2. These cells are located in the Hippocampal region , in or close to the regions: Dentate gyrus, molecular layer, Dentate gyrus, polymorph layer, Field CA3, stratum oriens, Dentate gyrus, granule cell layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5222 Astro-TE NN_2." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000496 ; owl:annotatedTarget "ZFA:0009223" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307042 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyMiBBc3Ryby1URSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307042 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.26" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307043 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.14" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307043 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.9" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307043 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "GO:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000497 ; owl:annotatedTarget "A photoreceptor cell that is sensitive to red light." . [] obo:CLM_0010002 "0.27" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307043 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.2777778"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307043 ; owl:annotatedTarget obo:CLM_5006973 . [] obo:STATO_0000663 "0.4878049"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307043 ; owl:annotatedTarget obo:CLM_5022193 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307043 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mcm6 (Mmus), Egfr (Mmus), Pcsk6 (Mmus). It is distinguished from other Astro-TE NN_2 cells by expression of Mcm6. These cells are located in the Hippocampal region , in or close to the regions: Dentate gyrus, molecular layer, Dentate gyrus, polymorph layer, Dentate gyrus, granule cell layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5223 Astro-TE NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307043 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyMyBBc3Ryby1URSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307043 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000497 ; owl:annotatedTarget "ZFA:0009224" ; sssom:mapping_justification . [] obo:CLM_0010002 "0.17" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307044 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.32" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307044 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.13" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307044 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.15" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307044 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.0"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307044 ; owl:annotatedTarget obo:CLM_5006974 . [] obo:STATO_0000663 "0.5851064"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307044 ; owl:annotatedTarget obo:CLM_5022194 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307044 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Cxcl5 (Mmus), Ddn (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Cxcl5, Kif5a. These cells are located in the Hippocampal region, Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5224 Astro-TE NN_3." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307044 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNCBBc3Ryby1URSBOTl8zAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307044 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] oboInOwl:hasDbXref "GOC:tfm", "http://en.wikipedia.org/wiki/Interneuron" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000498 ; owl:annotatedTarget "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." . [] obo:CLM_0010002 "0.71" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307045 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307045 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.0862069"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307045 ; owl:annotatedTarget obo:CLM_5006975 . [] obo:STATO_0000663 "0.43650794"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307045 ; owl:annotatedTarget obo:CLM_5022195 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307045 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Fam163a (Mmus), Kcnq3 (Mmus), Kcnq1ot1 (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Fam163a, Nr2f1, Kcnq1ot1. These cells are located in the Isocortex, Olfactory areas . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5225 Astro-TE NN_3." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000498 ; owl:annotatedTarget "ZFA:0009225" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307045 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNSBBc3Ryby1URSBOTl8zAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307045 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.29" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307046 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.39" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307046 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.3" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307046 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.19" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307046 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.0"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307046 ; owl:annotatedTarget obo:CLM_5006976 . [] obo:STATO_0000663 "0.5254777"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307046 ; owl:annotatedTarget obo:CLM_5022196 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307046 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Ranbp3l (Mmus), Emx2os (Mmus), Zic4 (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Zic4. These cells are located in the Lateral septal complex, Isocortex, Olfactory areas , in or close to the regions: Lateral septal nucleus, rostral (rostroventral) part . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5226 Astro-TE NN_3." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307046 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNiBBc3Ryby1URSBOTl8zAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307046 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D017154" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000499 ; owl:annotatedTarget "A connective tissue cell of an organ found in the loose connective tissue." . [] obo:CLM_0010002 "0.7" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307047 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.2" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307047 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.15" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307047 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.7" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307047 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.0"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307047 ; owl:annotatedTarget obo:CLM_5006977 . [] obo:STATO_0000663 "0.7017544"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307047 ; owl:annotatedTarget obo:CLM_5022197 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307047 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Crym (Mmus), Grin2c (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Crym, Gabbr2. These cells are located in the Striatum dorsal region, Striatum ventral region , in or close to the regions: Nucleus accumbens, Caudoputamen . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5227 Astro-TE NN_3." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307047 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNyBBc3Ryby1URSBOTl8zAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgE1MjI3IEFzdHJvLVRFIE5OXzMAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307047 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000499 ; owl:annotatedTarget "ZFA:0009226" ; sssom:mapping_justification . [] obo:CLM_0010002 "0.13" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307048 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.14" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307048 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.25" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307048 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.55" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307048 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.09259259"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307048 ; owl:annotatedTarget obo:CLM_5006978 . [] obo:STATO_0000663 "0.5102041"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307048 ; owl:annotatedTarget obo:CLM_5022198 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307048 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Thbs4 (Mmus), Gm29683 (Mmus), Slc39a12 (Mmus). It is distinguished from other Astro-TE NN cells by expression of Gm29683. These cells are located in the Cortical subplate, brain , in or close to the regions: Lateral amygdalar nucleus, external capsule . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5228 Astro-TE NN_4." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307048 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyOCBBc3Ryby1URSBOTl80AAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307048 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.15" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307049 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "MESH:D006107" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000501 ; owl:annotatedTarget "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." . [] obo:CLM_0010002 "0.19" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307049 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.39" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307049 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.13" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307049 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.11" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307049 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.58" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307049 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.0"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307049 ; owl:annotatedTarget obo:CLM_5006979 . [] obo:STATO_0000663 "0.16129032"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307049 ; owl:annotatedTarget obo:CLM_5022199 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307049 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Thbs4 (Mmus), Hs3st3a1 (Mmus), Sfrp1 (Mmus). It is distinguished from other Astro-TE NN_5 cells by expression of Hs3st3a1, Sfrp1. These cells are located in the Olfactory areas, brain , in or close to the regions: Anterior olfactory nucleus, corpus callosum, body, lateral ventricle, corpus callosum, anterior forceps . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5229 Astro-TE NN_5." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307049 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyOSBBc3Ryby1URSBOTl81AAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307049 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] oboInOwl:hasDbXref "DOI:10.1016/j.ejogrb.2004.01.010", "DOI:10.1093/humrep/del408", "DOI:10.1093/humupd/6.3.279", "DOI:10.1210/jcem-28-3-355", "DOI:10.3389/fendo.2019.00832/full" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000501 ; owl:annotatedTarget """Granulosa cells are a type of somatic cell most commonly known for their crucial role within the ovarian follicles of female mammalian species. Named for their grainy appearance, they are situated in the follicular epithelium, lining the inner part of the follicle and directly surrounding the oocyte. These cells stand as an integral part of the ovarian structure and function. One of the primary roles of granulosa cells is to aid in the production and secretion of sex hormones, particularly estrogen. They achieve this by working in tandem with theca cells, which stay attached to the external layer of the follicle. Theca cells produce androstenedione (a type of androgen) which granulosa cells then convert into estradiol, a form of estrogen, with the help of the enzyme aromatase. Moreover, granulosa cells participate in luteinization, transforming into luteal granulosa cells as a response to the luteinizing hormone during ovulation. This allows the formation of the corpus luteum, responsible for the secretion of progesterone necessary to maintain pregnancy. Granulosa cells also play a significant role in follicular development and oocyte maturation, involving close communication with the contained oocyte. They support the oocyte through the provision of nutrients and growth factors, control its meiotic cycle and ensure it is appropriately oriented and instructed for impending ovulation. Furthermore, granulosa cells contribute to the formation of the zona pellucida and the follicular fluid, providing an optimal environment for the oocyte's growth and maturation. These cells, thus, perform multiple vital roles, underscoring their importance in fertility and reproductive health. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] obo:CLM_0010002 "0.12" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307050 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.3" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307050 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.11" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307050 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.3" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307050 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.39" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307050 ; owl:annotatedTarget . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000501 ; owl:annotatedTarget "ZFA:0009227" ; sssom:mapping_justification . [] obo:CLM_0010002 "0.43" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307050 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.09259259"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307050 ; owl:annotatedTarget obo:CLM_5006980 . [] obo:STATO_0000663 "0.7474227"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307050 ; owl:annotatedTarget obo:CLM_5022200 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307050 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Adamts18 (Mmus), Crym (Mmus). It is distinguished from other Astro-TE NN_5 cells by expression of Adamts18. These cells are located in the Lateral septal complex, Striatum dorsal region, brain , in or close to the regions: Nucleus accumbens, Caudoputamen, lateral ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5230 Astro-TE NN_5." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307050 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIzMCBBc3Ryby1URSBOTl81AAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307050 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] a owl:Axiom ; rdfs:label "granulosa cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000501 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000501" . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307051 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.32" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307051 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.64" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307051 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.09259259"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307051 ; owl:annotatedTarget obo:CLM_5006981 . [] obo:STATO_0000663 "0.42372882"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307051 ; owl:annotatedTarget obo:CLM_5022201 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307051 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Chrdl1 (Mmus), Ano1 (Mmus), Il33 (Mmus). It is distinguished from other Astro-OLF NN_1 cells by expression of Greb1, Il33. These cells are located in the Olfactory areas, brain , in or close to the regions: Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5231 Astro-OLF NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307051 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307051 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] oboInOwl:hasDbXref "MESH:D019864" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000502 ; owl:annotatedTarget "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." . [] obo:CLM_0010002 "0.31" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307052 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.26" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307052 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.44" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307052 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.56" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307052 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.24193548"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307052 ; owl:annotatedTarget obo:CLM_5006982 . [] obo:STATO_0000663 "0.9"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307052 ; owl:annotatedTarget obo:CLM_5022202 . [] oboInOwl:hasDbXref "DOI:10.1016/j.pharmthera.2015.05.007", "DOI:10.1038/s41574-018-0020-6", "DOI:10.1093/annonc/mdh216", "https://www.sciencedirect.com/topics/neuroscience/somatostatin-cell" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000502 ; owl:annotatedTarget """Type D enteroendocrine cells, also known as D or delta cells, are specialized hormone-releasing cells found in the pancreas and also scattered throughout the lining of the gastrointestinal tract in mammals, notably within the stomach and the upper part of the small intestine known as the duodenum. The primary role of D cells is to produce and secrete somatostatin, a potent paracrine inhibitor. In the gastrointestinal tract, somatostatin slows down digestion. It reduces gastric acid secretion and slows down the rate of gastric emptying, thereby prolonging and controling the digestive p. Functionally, these effects are aimed at sustaining nutrient absorption to optimize energy extraction from consumed food. In the pancreas, D cells maintain a vital role in endocrine regulation. D cells in the pancreatic islands secrete somatostatin to inhibit the release of both insulin and glucagon from type A cells and B cells, glucoregulatory hormones that control blood sugar levels. Hence, D cells contribute considerably to the homeostasis of the body's metabolic processes. It is also noteworthy that dysfunctional D cells or irregular somatostatin signaling has been associated with certain pathologies such as neuroendocrine tumors and gastric ulcers. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307052 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Prss23 (Mmus), Stk32a (Mmus). It is distinguished from other Astro-OLF NN_1 cells by expression of Stk32a. These cells are located in the Olfactory areas, brain , in or close to the regions: olfactory nerve layer of main olfactory bulb, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5232 Astro-OLF NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307052 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307052 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.15" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307053 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.11" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307053 ; owl:annotatedTarget . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000502 ; owl:annotatedTarget "ZFA:0009228" ; sssom:mapping_justification . [] obo:CLM_0010002 "0.44" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307053 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.51" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307053 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.0"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307053 ; owl:annotatedTarget obo:CLM_5006983 . [] obo:STATO_0000663 "0.09259259"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307053 ; owl:annotatedTarget obo:CLM_5022203 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307053 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Hs3st3a1 (Mmus), Slc25a34 (Mmus), C4b (Mmus). It is distinguished from other Astro-OLF NN_2 cells by expression of Slc25a34, C4b. These cells are located in the Olfactory areas, brain , in or close to the regions: Main olfactory bulb, outer plexiform layer, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5233 Astro-OLF NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307053 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307053 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] a owl:Axiom ; rdfs:label "type D enteroendocrine cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000502 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000502" . [] obo:CLM_0010002 "0.29" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307054 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.29" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307054 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.14" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307054 ; owl:annotatedTarget . [] obo:CLM_0010002 "1.0" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307054 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.1724138"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307054 ; owl:annotatedTarget obo:CLM_5006984 . [] obo:STATO_0000663 "0.25641027"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307054 ; owl:annotatedTarget obo:CLM_5022204 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307054 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Chrdl1 (Mmus), Sfrp1 (Mmus), Atp13a4 (Mmus). It is distinguished from other Astro-OLF NN_2 cells by expression of Alk, Atp13a4. These cells are located in the Olfactory areas , in or close to the regions: Anterior olfactory nucleus, Main olfactory bulb, granule layer, Main olfactory bulb, mitral layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5234 Astro-OLF NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307054 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307054 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.63" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307055 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.9" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307055 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.35714287"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307055 ; owl:annotatedTarget obo:CLM_5006985 . [] obo:STATO_0000663 "0.71428573"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307055 ; owl:annotatedTarget obo:CLM_5022205 . [] oboInOwl:hasDbXref "MESH:D013799", "PMID:15833266", "PMID:36758341" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000503 ; owl:annotatedTarget "A specialized stromal cell that forms the theca layer outside the basal lamina lining the ovarian follicle, appearing during the secondary follicle stage." . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307055 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C230072F16Rik (Mmus), Dipk1c (Mmus), Ecrg4 (Mmus). It is distinguished from other Astro-OLF NN_3 cells by expression of Ecrg4. These cells are located in the Olfactory areas , in or close to the regions: Main olfactory bulb, granule layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5235 Astro-OLF NN_3." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307055 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307055 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.52" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307056 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.84" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307056 ; owl:annotatedTarget . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000503 ; owl:annotatedTarget "ZFA:0009229" ; sssom:mapping_justification . [] obo:CLM_0010002 "0.16" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307056 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.24193548"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307056 ; owl:annotatedTarget obo:CLM_5006986 . [] obo:STATO_0000663 "0.14705883"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307056 ; owl:annotatedTarget obo:CLM_5022206 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307056 ; owl:annotatedTarget "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), 6530411M01Rik (Mmus), Sfrp1 (Mmus), Aqp4 (Mmus). It is distinguished from other Astro-OLF NN_3 cells by expression of Sfrp1, Aqp4. These cells are located in the Olfactory areas , in or close to the regions: Main olfactory bulb, granule layer, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5236 Astro-OLF NN_3." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307056 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307056 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D019861" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000504 ; owl:annotatedTarget "A enteroendocrine cell part of the glands of the gastric mucosa. They produce histamine and peptides such as chromogranins. This cell type respond to gastrin by releasing histamine which acts as a paracrine stimulator of the release of hydrochloric acid from the gastric parietal cells." . [] obo:CLM_0010002 "0.58" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307063 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.24" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307063 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.88" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307063 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.82191783"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307063 ; owl:annotatedTarget obo:CLM_5006993 . [] obo:STATO_0000663 "0.9347826"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307063 ; owl:annotatedTarget obo:CLM_5022213 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307063 ; owl:annotatedTarget "A tanycyte of subfornical organ of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cnmd (Mmus), Sfta3-ps (Mmus). It is distinguished from other Tanycyte NN_1 cells by expression of Cnmd. These cells are located in the brain , in or close to the regions: choroid plexus, third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5243 Tanycyte NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307063 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0MyBUYW55Y3l0ZSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307063 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] oboInOwl:hasDbXref "GO:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000505 ; owl:annotatedTarget "A peptide hormone secreting cell that secretes substance P." . [] obo:CLM_0010002 "0.34" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307064 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.34" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307064 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.61" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307064 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.7017544"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307064 ; owl:annotatedTarget obo:CLM_5006994 . [] obo:STATO_0000663 "0.8208955"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307064 ; owl:annotatedTarget obo:CLM_5022214 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307064 ; owl:annotatedTarget "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C230072F16Rik (Mmus), Glp1r (Mmus). It is distinguished from other Tanycyte NN_1 cells by expression of Glp1r. These cells are located in the Hypothalamus, brain , in or close to the regions: Anteroventral periventricular nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5244 Tanycyte NN_1." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000505 ; owl:annotatedTarget "ZFA:0009230" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307064 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0NCBUYW55Y3l0ZSBOTl8xAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgE1MjQ0IFRhbnljeXRlIE5OXzEAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307064 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] oboInOwl:evidence ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_4307065 ; owl:annotatedTarget obo:CL_4042017 . [] a owl:Axiom ; rdfs:comment "Inferred to be glutamate secretion, neurotransmission based on expression of Slc17a8" ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_4307065 ; owl:annotatedTarget _:genid18447 . [] obo:CLM_0010002 "0.92" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307065 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "GO:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000506 ; owl:annotatedTarget "An endorphine cell that secretes enkephalin." . [] obo:CLM_0010002 "0.88" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307065 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.24193548"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307065 ; owl:annotatedTarget obo:CLM_5006995 . [] obo:STATO_0000663 "0.78313255"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307065 ; owl:annotatedTarget obo:CLM_5022215 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307065 ; owl:annotatedTarget "A alpha1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dynlrb2 (Mmus), Mylk3 (Mmus), Sfta3-ps (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Mylk3. It is glutamatergic. These cells are located in the Hypothalamus , in or close to the regions: Periventricular hypothalamic nucleus, intermediate part . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5245 Tanycyte NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307065 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0NSBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307065 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000506 ; owl:annotatedTarget "ZFA:0009231" ; sssom:mapping_justification . [] obo:CLM_0010002 "0.73" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307066 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.47" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307066 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.24" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307066 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.11" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307066 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.27" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307066 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.18292683"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307066 ; owl:annotatedTarget obo:CLM_5006996 . [] obo:STATO_0000663 "0.6321839"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307066 ; owl:annotatedTarget obo:CLM_5022216 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307066 ; owl:annotatedTarget "A alpha1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ccdc170 (Mmus), Nkx2-4 (Mmus), Dock8 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Mroh5. These cells are located in the Hypothalamus, brain , in or close to the regions: Periventricular hypothalamic nucleus, intermediate part, third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5246 Tanycyte NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307066 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0NiBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] oboInOwl:hasDbXref "GO:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000507 ; owl:annotatedTarget "A peptide hormone secreting cell that secretes endorphin." . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307066 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.94" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307067 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.29" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307067 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.6" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307067 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.0"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307067 ; owl:annotatedTarget obo:CLM_5006997 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000507 ; owl:annotatedTarget "ZFA:0009232" ; sssom:mapping_justification . [] obo:STATO_0000663 "0.61403507"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307067 ; owl:annotatedTarget obo:CLM_5022217 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307067 ; owl:annotatedTarget "A alpha2-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdzph1 (Mmus), Wdr63 (Mmus), Dscaml1 (Mmus), P3h2 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Dscaml1, P3h2. These cells are located in the Hypothalamus , in or close to the regions: Periventricular hypothalamic nucleus, posterior part, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5247 Tanycyte NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307067 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0NyBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307067 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.69" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307068 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "MESH:D019863", "PMID:10700044", "PMID:35674015", "PMID:37240181" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000508 ; owl:annotatedTarget "An endocrine cell found in the stomach and duodenum and is responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." . [] obo:CLM_0010002 "0.69" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307068 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.31" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307068 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.31" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307068 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.44642857"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307068 ; owl:annotatedTarget obo:CLM_5006998 . [] obo:STATO_0000663 "0.5681818"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307068 ; owl:annotatedTarget obo:CLM_5022218 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307068 ; owl:annotatedTarget "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ccdc146 (Mmus), Tbx3 (Mmus), Otx2 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Otx2, Nkx2-4. These cells are located in the Hypothalamus, brain , in or close to the regions: Periventricular hypothalamic nucleus, posterior part, third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5248 Tanycyte NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307068 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0OCBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307068 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] oboInOwl:hasDbXref "GO:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000509 ; owl:annotatedTarget "A peptide hormone secreting cell that secretes gastrin." . [] obo:CLM_0010002 "0.78" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307069 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.22" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307069 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.76" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307069 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.22" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307069 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.24193548"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307069 ; owl:annotatedTarget obo:CLM_5006999 . [] obo:STATO_0000663 "0.75842696"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307069 ; owl:annotatedTarget obo:CLM_5022219 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307069 ; owl:annotatedTarget "A beta1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr50 (Mmus), Frzb (Mmus), Foxd2os (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Col25a1, C230072F16Rik. These cells are located in the Hypothalamus, brain , in or close to the regions: third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5249 Tanycyte NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307069 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0OSBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307069 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.46" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307070 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.75" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307070 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.19" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307070 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.29" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307070 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.25" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307070 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.7364341"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307070 ; owl:annotatedTarget obo:CLM_5007000 . [] obo:STATO_0000663 "0.47619048"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307070 ; owl:annotatedTarget obo:CLM_5022220 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307070 ; owl:annotatedTarget "A beta2-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Fndc3c1 (Mmus), Ecrg4 (Mmus). It is distinguished from other Tanycyte NN cells by expression of Ecrg4. These cells are located in the Hypothalamus, brain , in or close to the regions: Median eminence, third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5250 Tanycyte NN_3." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307070 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI1MCBUYW55Y3l0ZSBOTl8zAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307070 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] oboInOwl:evidence ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_4307083 ; owl:annotatedTarget obo:CL_4023181 . [] obo:CLM_0010002 "0.48" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307083 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.11" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307083 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.32" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307083 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.23" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307083 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.68" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307083 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.92105263"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307083 ; owl:annotatedTarget obo:CLM_5007013 . [] obo:STATO_0000663 "0.89805824"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307083 ; owl:annotatedTarget obo:CLM_5007984 . [] oboInOwl:hasDbXref "doi:10.3389/fncel.2015.00480", "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307083 ; owl:annotatedTarget "A hypendymal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Sspo (Mmus), Wfdc2 (Mmus). It is distinguished from other Astro-Epen cells by expression of Sspo, Wfdc2. These cells are located in the Midbrain, brain , in or close to the regions: third ventricle, posterior commissure, Subcommissural organ . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5263 Hypendymal NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307083 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2MyBIeXBlbmR5bWFsIE5OXzEAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNjMgSHlwZW5keW1hbCBOTl8xAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307083 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307084 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.49" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307084 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "MESH:D019879", "PMID:29184701", "PMID:32308658", "PMID:33484640" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000510 ; owl:annotatedTarget "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix." . [] obo:CLM_0010002 "0.24" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307084 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.74" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307084 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.6818182"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307084 ; owl:annotatedTarget obo:CLM_5007014 . [] obo:STATO_0000663 "0.9405941"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307084 ; owl:annotatedTarget obo:CLM_5022234 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307084 ; owl:annotatedTarget "A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus), Tbc1d1 (Mmus). It is distinguished from other CHOR NN cells by expression of Tbc1d1. These cells are located in the Cerebellum, brain , in or close to the regions: Paraflocculus, choroid plexus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5264 CHOR NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307084 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2NCBDSE9SIE5OXzEAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNjQgQ0hPUiBOTl8xAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307084 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] oboInOwl:hasDbXref "DOI:10.1007/s00018-002-8412-z", "DOI:10.1038/nature09637", "DOI:10.1038/nrmicro2546", "DOI:10.1146/annurev-physiol-030212-183744", "DOI:10.3389/fimmu.2020.00587" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000510 ; owl:annotatedTarget """Paneth cells are specialized epithelial cells that are primarily located at the bottom of the crypts of Lieberkühn in the small intestine, where they play a pivotal role in maintaining gut homeostasis. They have also been found in smaller numbers in the colonic crypts and other parts of the gastrointestinal tract. Paneth cells are characterized by large acidophilic granules, which take up most of the cytoplasmic volume, causing the nucleus to be pushed toward the base of the cell. Paneth cells function as a part of the innate immune system. The large granules inside the cells are filled with antimicrobial peptides, such as defensins and lysozymes. Upon bacterial intrusion or cellular signaling indicating a potential infection, Paneth cells release the granules containing the antimicrobial substances into the crypt lumen, effectively serving as the first line of defense against bacterial invasion within the gastrointestinal tract. In essence, Paneth cells serve as guardians, protecting the intestinal stem cells from harmful pathogens that may disturb the gut ecosystem. In addition to their primary role in immunity, Paneth cells are also crucial for supporting the stem cell niche in the intestinal crypts. They are located adjacent to Lgr5+ stem cells and secrete various growth factors such as EGF, TGF-alpha, Wnt3, and Notch ligand Dll4. These factors regulate the self-renewal and differentiation of these stem cells, which continuously replenish the intestinal epithelium. Consequently, any abnormality or dysfunction in Paneth cells could lead to a disturbance in gut homeostasis, possibly resulting in various illnesses such as inflammatory bowel disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:comment "Inferred to be glutamate secretion, neurotransmission based on expression of Slc17a8" ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_4307085 ; owl:annotatedTarget _:genid18562 . [] obo:CLM_0010002 "0.18" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307085 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.22" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307085 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.81" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307085 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.8227848"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307085 ; owl:annotatedTarget obo:CLM_5007015 . [] obo:STATO_0000663 "0.86206895"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307085 ; owl:annotatedTarget obo:CLM_5022235 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307085 ; owl:annotatedTarget "A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus), Slc17a8 (Mmus). It is distinguished from other CHOR NN cells by expression of Slc17a8. It is glutamatergic. These cells are located in the brain , in or close to the regions: choroid plexus, lateral ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5265 CHOR NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307085 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2NSBDSE9SIE5OXzEAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNjUgQ0hPUiBOTl8xAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" . [] a owl:Axiom ; rdfs:label "paneth cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000510 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000510" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_30" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307085 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" . [] obo:CLM_0010002 "0.52" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307086 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.14" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307086 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.40697673"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307086 ; owl:annotatedTarget obo:CLM_5007016 . [] obo:STATO_0000663 "0.40816328"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307086 ; owl:annotatedTarget obo:CLM_5022236 . [] oboInOwl:hasDbXref "GO:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000511 ; owl:annotatedTarget "A peptide hormone secreting cell that secretes androgen binding protein." . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307086 ; owl:annotatedTarget "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Pclaf (Mmus), Mki67 (Mmus), Foxg1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Neil3, Foxg1. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5266 OPC NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307086 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307086 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.21" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307087 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.13" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307087 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.14" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307087 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.17" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307087 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.23" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307087 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.7246377"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307087 ; owl:annotatedTarget obo:CLM_5007017 . [] obo:STATO_0000663 "0.6557377"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307087 ; owl:annotatedTarget obo:CLM_5022237 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307087 ; owl:annotatedTarget "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Pclaf (Mmus), Irx2 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Neil3, Irx2. These cells are located in the Cerebellum, brain, Midbrain, Pons, Medulla . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5267 OPC NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307087 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307087 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.53" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307088 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.12" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307088 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307088 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.18518518"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307088 ; owl:annotatedTarget obo:CLM_5007018 . [] obo:STATO_0000663 "0.18656716"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307088 ; owl:annotatedTarget obo:CLM_5022238 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307088 ; owl:annotatedTarget "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Mms22l (Mmus), Top2a (Mmus). It is distinguished from other OPC NN_1 cells by expression of Mms22l, Foxg1, Top2a. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5268 OPC NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307088 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307088 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.17" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307089 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.11" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307089 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.16" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307089 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.38235295"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307089 ; owl:annotatedTarget obo:CLM_5007019 . [] obo:STATO_0000663 "0.41366908"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307089 ; owl:annotatedTarget obo:CLM_5022239 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307089 ; owl:annotatedTarget "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Col27a1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Col27a1. These cells are located in the Midbrain, Pons, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5269 OPC NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307089 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307089 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.17" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307090 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.39" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307090 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307090 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307090 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.0"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307090 ; owl:annotatedTarget obo:CLM_5007020 . [] obo:STATO_0000663 "0.37190083"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307090 ; owl:annotatedTarget obo:CLM_5022240 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307090 ; owl:annotatedTarget "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Rmi2 (Mmus), Col27a1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Rmi2, Col27a1. These cells are located in the Hypothalamus, Midbrain, Pallidum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5270 OPC NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307090 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307090 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.26" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307091 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.17" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307091 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.6372549"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307091 ; owl:annotatedTarget obo:CLM_5007021 . [] obo:STATO_0000663 "0.92105263"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307091 ; owl:annotatedTarget obo:CLM_5022241 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307091 ; owl:annotatedTarget "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Cenpf (Mmus), Cenpa (Mmus). It is distinguished from other OPC NN cells by expression of Cenpa. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5271 OPC NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307091 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307091 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.22" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307092 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.2" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307092 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.3888889"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307092 ; owl:annotatedTarget obo:CLM_5007022 . [] obo:STATO_0000663 "0.54347825"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307092 ; owl:annotatedTarget obo:CLM_5022242 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307092 ; owl:annotatedTarget "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bmp4 (Mmus), Zfp36l1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Rgcc, Plpp4. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5272 COP NN_1." . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D032386" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000513 ; owl:annotatedTarget "A precursor cell destined to differentiate into cardiac muscle cell." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307092 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307092 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.33" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307093 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.2" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307093 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.08064516"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307093 ; owl:annotatedTarget obo:CLM_5007023 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000513 ; owl:annotatedTarget "ZFA:0009234" ; sssom:mapping_justification . [] obo:STATO_0000663 "0.48245615"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307093 ; owl:annotatedTarget obo:CLM_5022243 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307093 ; owl:annotatedTarget "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Gp1bb (Mmus), Pdzd2 (Mmus), Plekhg1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Rgcc, 9130019P16Rik. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5273 COP NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307093 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3MyBDT1AgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3MyBDT1AgTk5fMQAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307093 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.41" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307094 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.0"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307094 ; owl:annotatedTarget obo:CLM_5007024 . [] obo:STATO_0000663 "0.1724138"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307094 ; owl:annotatedTarget obo:CLM_5022244 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307094 ; owl:annotatedTarget "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bgn (Mmus), Gstp1 (Mmus), C1ql1 (Mmus). It is distinguished from other COP NN_1 cells by expression of C1ql1, Gstp1. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5274 COP NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307094 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307094 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.37" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307095 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.3539823"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307095 ; owl:annotatedTarget obo:CLM_5007025 . [] obo:STATO_0000663 "0.35135135"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307095 ; owl:annotatedTarget obo:CLM_5022245 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307095 ; owl:annotatedTarget "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Bmp4 (Mmus), Mob3b (Mmus). It is distinguished from other COP NN_1 cells by expression of Bmp4, Mob3b. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5275 COP NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307095 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307095 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.51" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307096 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.31914893"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307096 ; owl:annotatedTarget obo:CLM_5007026 . [] obo:STATO_0000663 "0.0"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307096 ; owl:annotatedTarget obo:CLM_5022246 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307096 ; owl:annotatedTarget "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Rab32 (Mmus), Opalin (Mmus). It is distinguished from other COP NN_1 cells by expression of Vwc2, Opalin. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5276 COP NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307096 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307096 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.54" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307097 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.11" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307097 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307097 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.22727273"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307097 ; owl:annotatedTarget obo:CLM_5007027 . [] obo:STATO_0000663 "0.27027026"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307097 ; owl:annotatedTarget obo:CLM_5022247 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307097 ; owl:annotatedTarget "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Bmp4 (Mmus), Cck (Mmus), Ptger1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Bmp4, Cck, Ptger1. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5277 COP NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307097 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307097 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.31" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307098 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307098 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.12" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307098 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.17482518"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307098 ; owl:annotatedTarget obo:CLM_5007028 . [] obo:STATO_0000663 "0.29801324"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307098 ; owl:annotatedTarget obo:CLM_5022248 . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D032390" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000514 ; owl:annotatedTarget "A precursor cell destined to differentiate into smooth muscle myocytes." . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307098 ; owl:annotatedTarget "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Grin2b (Mmus). It is distinguished from other NFOL NN_2 cells by expression of 9630013A20Rik, Grin2b. These cells are located in the Midbrain, Thalamus, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5278 NFOL NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307098 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3OCBORk9MIE5OXzIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNzggTkZPTCBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307098 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.24" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307099 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.25" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307099 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "DOI:10.1074/jbc.RA118.001739", "https://www.ncbi.nlm.nih.gov/books/NBK544225/", "https://www.sciencedirect.com/topics/medicine-and-dentistry/smooth-muscle" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000514 ; owl:annotatedTarget """A precursor to the smooth muscle cell, the smooth muscle myoblast, is integral to various body systems, including the cardiovascular, gastrointestinal, and respiratory systems. Smooth muscle myoblasts arise from the differentiation of mesenchymal stem cells, a process tightly regulated by specific genetic factors and environmental signals. Their role extends to myogenesis, particularly in the formation of muscular tissue, especially during embryonic development. Smooth muscle myoblasts possess distinctive cellular characteristics. In contrast to skeletal muscle myoblasts, they do not fuse to create multinucleated fibers. Instead, they differentiate into individual, uninucleated smooth muscle cells. This differentiation unfolds in two distinct phases: proliferation, marked by rapid division to increase cell numbers, and differentiation, involving structural and functional transformation into mature smooth muscle cells. This intricate process is intricately mediated by various signaling molecules and transcription factors. Functionally, smooth muscle myoblasts and the mature muscle cells they generate play pivotal roles in various physiological processes. Smooth muscle cells orchestrate involuntary muscle responses and are integral to body systems that regulate blood flow, propel food along the digestive tract, and control airflow in the respiratory tract. These diverse functions underscore the significance of smooth muscle myoblasts in the body's growth, maintenance, and overall function. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] obo:STATO_0000663 "0.5392157"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307099 ; owl:annotatedTarget obo:CLM_5007029 . [] obo:STATO_0000663 "0.7281553"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307099 ; owl:annotatedTarget obo:CLM_5022249 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307099 ; owl:annotatedTarget "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Dbx2 (Mmus), Rassf10 (Mmus). It is distinguished from other NFOL NN_2 cells by expression of Dbx2, Rassf10. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5279 NFOL NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307099 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3OSBORk9MIE5OXzIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNzkgTkZPTCBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307099 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000514 ; owl:annotatedTarget "ZFA:0009235" ; sssom:mapping_justification . [] obo:CLM_0010002 "0.18" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307100 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.28" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307100 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.32051283"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307100 ; owl:annotatedTarget obo:CLM_5007030 . [] obo:STATO_0000663 "0.4878049"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307100 ; owl:annotatedTarget obo:CLM_5022250 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307100 ; owl:annotatedTarget "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Rgs16 (Mmus), Rhbdl2 (Mmus). It is distinguished from other NFOL NN_2 cells by expression of Rgs16, Rhbdl2. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5280 NFOL NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307100 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MCBORk9MIE5OXzIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyODAgTkZPTCBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307100 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] oboInOwl:hasDbXref "MESH:D032390" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000514 ; owl:annotatedTarget "myoblast, smooth muscle" . [] obo:CLM_0010002 "0.19" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307101 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.3" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307101 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.35714287"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307101 ; owl:annotatedTarget obo:CLM_5007031 . [] obo:STATO_0000663 "0.7368421"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307101 ; owl:annotatedTarget obo:CLM_5022251 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307101 ; owl:annotatedTarget "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Piezo2 (Mmus), Ptprb (Mmus). It is distinguished from other NFOL NN_2 cells by expression of Il23a, Opalin, Ptprb. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5281 NFOL NN_2." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307101 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MSBORk9MIE5OXzIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyODEgTkZPTCBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307101 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] a owl:Axiom ; rdfs:label "smooth muscle myoblast on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000514 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000514" . [] obo:CLM_0010002 "0.26" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307102 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.26" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307102 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.4054054"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307102 ; owl:annotatedTarget obo:CLM_5007032 . [] obo:STATO_0000663 "0.5"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307102 ; owl:annotatedTarget obo:CLM_5022252 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307102 ; owl:annotatedTarget "A myelin-forming oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Opalin (Mmus), Cxcl12 (Mmus), Efhd1 (Mmus). It is distinguished from other MFOL NN_3 cells by expression of Cxcl12, Efhd1. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5282 MFOL NN_3." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307102 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MiBNRk9MIE5OXzMAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyODIgTUZPTCBOTl8zAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307102 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307103 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.17" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307103 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.29" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307103 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.35714287"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307103 ; owl:annotatedTarget obo:CLM_5007033 . [] obo:STATO_0000663 "0.48387095"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307103 ; owl:annotatedTarget obo:CLM_5022253 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307103 ; owl:annotatedTarget "A myelin-forming oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Ppp1r14a (Mmus), Mroh3 (Mmus). It is distinguished from other MFOL NN_3 cells by expression of Il23a, Ppp1r14a. These cells are located in the Midbrain, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5283 MFOL NN_3." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307103 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MyBNRk9MIE5OXzMAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyODMgTUZPTCBOTl8zAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307103 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.11" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307104 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.37" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307104 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.48507464"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307104 ; owl:annotatedTarget obo:CLM_5007034 . [] obo:STATO_0000663 "0.5"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307104 ; owl:annotatedTarget obo:CLM_5022254 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307104 ; owl:annotatedTarget "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Prr5l (Mmus), Hapln2 (Mmus), Enpp6 (Mmus), Grm7 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Plin3, Grm7. These cells are located in the Medulla, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5284 MOL NN_4." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307104 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307104 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.14" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307105 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.13" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307105 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.27" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307105 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.24193548"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307105 ; owl:annotatedTarget obo:CLM_5007035 . [] obo:STATO_0000663 "0.32786885"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307105 ; owl:annotatedTarget obo:CLM_5022255 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307105 ; owl:annotatedTarget "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), A230001M10Rik (Mmus), Spock3 (Mmus), Rhoj (Mmus). It is distinguished from other MOL NN_4 cells by expression of Spock3, Rhoj. These cells are located in the Midbrain, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5285 MOL NN_4." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307105 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307105 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.17" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307106 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.15" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307106 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.44" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307106 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.7876712"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307106 ; owl:annotatedTarget obo:CLM_5007036 . [] obo:STATO_0000663 "0.94017094"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307106 ; owl:annotatedTarget obo:CLM_5022256 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307106 ; owl:annotatedTarget "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Klk6 (Mmus), Dlc1 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Art3. These cells are located in the Medulla, Pons, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5286 MOL NN_4." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307106 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307106 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.17" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307107 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.41" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307107 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.33333334"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307107 ; owl:annotatedTarget obo:CLM_5007037 . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000515 ; owl:annotatedTarget "A myoblast that differentiates into skeletal muscle fibers." . [] obo:STATO_0000663 "0.34313726"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307107 ; owl:annotatedTarget obo:CLM_5022257 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307107 ; owl:annotatedTarget "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Opalin (Mmus), Grm3 (Mmus), Gm5087 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Il33, Gm5087. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5287 MOL NN_4." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307107 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4NyBNT0wgTk5fNAAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4NyBNT0wgTk5fNAAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307107 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.11" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307108 ; owl:annotatedTarget . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000515 ; owl:annotatedTarget "ZFA:0009236" ; sssom:mapping_justification . [] obo:CLM_0010002 "0.41" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307108 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.36231884"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307108 ; owl:annotatedTarget obo:CLM_5007038 . [] obo:STATO_0000663 "0.43333334"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307108 ; owl:annotatedTarget obo:CLM_5022258 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307108 ; owl:annotatedTarget "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mog (Mmus), Anln (Mmus), Gm32633 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Sspo, Selenop. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5288 MOL NN_4." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307108 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4OCBNT0wgTk5fNAAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4OCBNT0wgTk5fNAAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_31" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307108 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" . [] obo:CLM_0010002 "0.15" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307109 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.89" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307109 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.71428573"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307109 ; owl:annotatedTarget obo:CLM_5007039 . [] obo:STATO_0000663 "0.7773109"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307109 ; owl:annotatedTarget obo:CLM_5022259 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307109 ; owl:annotatedTarget "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn5 (Mmus), Adamts12 (Mmus). It is distinguished from other OEC cells by expression of Adamts12. These cells are located in the brain , in or close to the regions: olfactory nerve layer of main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5289 OEC NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307109 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_32" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307109 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_32.h5ad" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D027161" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000516 ; owl:annotatedTarget "A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia." . [] obo:CLM_0010002 "0.39" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307110 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.8" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307110 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.49019608"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307110 ; owl:annotatedTarget obo:CLM_5007040 . [] obo:STATO_0000663 "0.5479452"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307110 ; owl:annotatedTarget obo:CLM_5022260 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307110 ; owl:annotatedTarget "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Aqp1 (Mmus), Cldn5 (Mmus). It is distinguished from other OEC cells by expression of Gdpd4, Cldn5. These cells are located in the brain , in or close to the regions: olfactory nerve layer of main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5290 OEC NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307110 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_32" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307110 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_32.h5ad" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000516 ; owl:annotatedTarget "ZFA:0009237" ; sssom:mapping_justification . [] obo:CLM_0010002 "0.14" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307111 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.16" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF acronym region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307111 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.36" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307111 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.64" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307111 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.44444445"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307111 ; owl:annotatedTarget obo:CLM_5007041 . [] obo:STATO_0000663 "0.77956986"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307111 ; owl:annotatedTarget obo:CLM_5022261 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307111 ; owl:annotatedTarget "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Mybpc1 (Mmus), Syk (Mmus). It is distinguished from other OEC cells by expression of A330076C08Rik. These cells are located in the Olfactory areas, brain , in or close to the regions: olfactory nerve layer of main olfactory bulb, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5291 OEC NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307111 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_32" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307111 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_32.h5ad" . [] a owl:Axiom ; rdfs:comment "Inferred to be glutamate secretion, neurotransmission based on expression of Slc17a7" ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_4307112 ; owl:annotatedTarget _:genid18900 . [] oboInOwl:hasDbXref "GOC:add", "PMID:20213546" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000517 ; owl:annotatedTarget "A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." . [] obo:CLM_0010002 "0.85" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307112 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.09259259"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307112 ; owl:annotatedTarget obo:CLM_5007042 . [] obo:STATO_0000663 "0.46153846"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307112 ; owl:annotatedTarget obo:CLM_5022262 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307112 ; owl:annotatedTarget "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Mybpc1 (Mmus), Rasgef1c (Mmus). It is distinguished from other OEC cells by expression of Rasgef1c. It is glutamatergic. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5292 OEC NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307112 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI5MiBPRUMgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI5MiBPRUMgTk5fMQAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_32" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307112 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_32.h5ad" . [] obo:CLM_0010002 "0.73" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307113 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.6603774"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307113 ; owl:annotatedTarget obo:CLM_5007043 . [] obo:STATO_0000663 "0.7876712"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307113 ; owl:annotatedTarget obo:CLM_5022263 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307113 ; owl:annotatedTarget "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc47a1 (Mmus), Pde11a (Mmus). It is distinguished from other ABC NN cells by expression of Pde11a. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5293 ABC NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307113 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_33" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307113 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_33.h5ad" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000518 ; owl:annotatedTarget "A phagocyte in vertebrates that is able to phagocytosis." . [] obo:CLM_0010002 "0.76" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307114 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.6818182"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307114 ; owl:annotatedTarget obo:CLM_5007044 . [] obo:STATO_0000663 "0.023364486"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307114 ; owl:annotatedTarget obo:CLM_5022264 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307114 ; owl:annotatedTarget "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc47a1 (Mmus), Dapl1 (Mmus). It is distinguished from other ABC NN cells by expression of Dapl1. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5294 ABC NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307114 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI5NCBBQkMgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI5NCBBQkMgTk5fMQAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_33" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307114 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_33.h5ad" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000519 ; owl:annotatedTarget "A phagocyte from organisms in the Nematoda or Protostomia clades." . [] obo:CLM_0010002 "0.74" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307115 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.86419755"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307115 ; owl:annotatedTarget obo:CLM_5007045 . [] obo:STATO_0000663 "0.9"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307115 ; owl:annotatedTarget obo:CLM_5022265 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307115 ; owl:annotatedTarget "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Prg4 (Mmus), Cubn (Mmus). It is distinguished from other ABC NN cells by expression of Cubn. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5295 ABC NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307115 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_33" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307115 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_33.h5ad" . [] obo:CLM_0010002 "0.29" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307132 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.17" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307132 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.982906"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307132 ; owl:annotatedTarget obo:CLM_5007062 . [] obo:STATO_0000663 "0.9684685"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307132 ; owl:annotatedTarget obo:CLM_5007994 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307132 ; owl:annotatedTarget "A microglial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C1qa (Mmus), Tmem119 (Mmus). It is distinguished from other Immune cells by expression of C1qa, Tmem119. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5312 Microglia NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307132 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_34" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307132 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_34.h5ad" . [] obo:CLM_0010002 "0.1" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307133 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.13" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307133 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.34" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307133 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.5479452"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307133 ; owl:annotatedTarget obo:CLM_5007063 . [] obo:STATO_0000663 "0.16666667"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307133 ; owl:annotatedTarget obo:CLM_5022283 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307133 ; owl:annotatedTarget "A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Pf4 (Mmus). It is distinguished from other BAM NN cells by expression of Mrc1, Pf4. These cells are located in the Medulla, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5313 BAM NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307133 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_34" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307133 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_34.h5ad" . [] obo:CLM_0010002 "0.14" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307134 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.16" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307134 ; owl:annotatedTarget . [] obo:CLM_0010002 "0.26" ; obo:OBI_0000070 ; a owl:Axiom ; rdfs:comment "Location assignment based on CCF broad region." ; owl:annotatedProperty obo:CLM_0010001 ; owl:annotatedSource obo:CL_4307134 ; owl:annotatedTarget . [] obo:STATO_0000663 "0.7746479"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307134 ; owl:annotatedTarget obo:CLM_5007064 . [] obo:STATO_0000663 "0.8695652"^^xsd:float ; a owl:Axiom ; owl:annotatedProperty obo:CLM_0010003 ; owl:annotatedSource obo:CL_4307134 ; owl:annotatedTarget obo:CLM_5022284 . [] oboInOwl:hasDbXref "https://doi.org/10.1038/s41586-023-06812-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4307134 ; owl:annotatedTarget "A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Pf4 (Mmus), Fos (Mmus). It is distinguished from other BAM NN cells by expression of Fos. These cells are located in the Isocortex, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5314 BAM NN_1." . [] a owl:Axiom ; rdfs:label "Reference data on Allen Brain Cell Atlas" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307134 ; owl:annotatedTarget "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" . [] a owl:Axiom ; rdfs:comment "Warning large data file!" ; rdfs:label "h5ad data file for CS20230722_CLAS_34" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_4307134 ; owl:annotatedTarget "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_34.h5ad" . [] a owl:Class ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005634 ] ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] ) . [] a owl:Class ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005634 ] ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] ) . [] a owl:Class ; rdfs:subClassOf obo:CL_0000164 ; owl:intersectionOf (obo:CL_0000163 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ) . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000521 ; owl:annotatedTarget "Any cell that in taxon some Fungi." . [] a owl:Class ; rdfs:subClassOf obo:CL_0000164 ; owl:intersectionOf (obo:CL_0000163 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) . [] a owl:Class ; rdfs:subClassOf obo:CL_0000164 ; owl:intersectionOf (obo:CL_0000163 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) . [] oboInOwl:hasDbXref "ISBN:08199377X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000522 ; owl:annotatedTarget "OBSOLETE: The reproductive structure of bacteria, fungi and cryptograms." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource [ a owl:Class ; rdfs:subClassOf _:genid19007 ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002162 ; owl:someValuesFrom obo:NCBITaxon_7742 ] ) ] ; owl:annotatedTarget _:genid19007 . [] a owl:Restriction ; owl:disjointWith [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005576 ] ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000000 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0323052908" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000523 ; owl:annotatedTarget "A cell from the inner layer of the trophoblast of the early mammalian embryo that gives rise to the outer surface and villi of the chorion. Mononuclear crytoblasts fuse to give rise to a multinuclear cytotrophoblast." . [] oboInOwl:hasDbXref "MESH:D013104" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000524 ; owl:annotatedTarget "A cell, usually of bacteria or yeast, which has partially lost its cell wall." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0323052908" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000525 ; owl:annotatedTarget "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." . [] oboInOwl:hasDbXref "PMID:11787150" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000525 ; owl:annotatedTarget "syncytial trophoblast cell" . [] oboInOwl:hasDbXref "PMID:21733368" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000525 ; owl:annotatedTarget "syncytiotrophoblastic cell" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D009475" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000526 ; owl:annotatedTarget "A neuron which conveys sensory information centrally from the periphery." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000526 ; owl:annotatedTarget "ZFA:0009238" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "MESH:D009476" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000527 ; owl:annotatedTarget "A neuron which sends impulses peripherally to activate muscles or secretory cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000527 ; owl:annotatedTarget "ZFA:0009239" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "MESH:D026602" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000528 ; owl:annotatedTarget "A nerve cell where transmission is mediated by nitric oxide." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000528 ; owl:annotatedTarget "ZFA:0009240" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000529 ; owl:annotatedTarget "ZFA:0009241" ; sssom:mapping_justification . [] obo:IAO_0000233 "https://github.com/obophenotype/cell-ontology/pull/1950" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000530 ; owl:annotatedTarget _:genid1931 . [] oboInOwl:hasDbXref "PMID:1842357", "doi:10.1242/dev.108.1.121" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000530 ; owl:annotatedTarget "A neuron that develops during the early segmentation stages in teleosts, before the neural tube is formed." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000530 ; owl:annotatedTarget "ZFA:0009242" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:1842357" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000531 ; owl:annotatedTarget "A primary neuron (sensu Teleostei) that has a sensory function." . [] oboInOwl:hasDbXref "PMID:17971221", "PMID:35431796" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000532 ; owl:annotatedTarget "A primary motor neuron with its soma in the caudal region of a spinal cord. The axon of this motoneuron exit the spinal cord from one single point and innervates the lateral surface of ventral axial muscles" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000532 ; owl:annotatedTarget "ZFA:0009243" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:3746410" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000532 ; owl:annotatedTarget "CaP motorneuron" . [] oboInOwl:hasDbXref "PMID:17971221" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000532 ; owl:annotatedTarget "cap cell" . [] oboInOwl:hasDbXref "PMID:18077593" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000532 ; owl:annotatedTarget "caudal primary motor neuron" . [] oboInOwl:hasDbXref "PMID:1842357" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000533 ; owl:annotatedTarget "A primary neuron (sensu Teleostei) that has a motor function." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000533 ; owl:annotatedTarget "ZFA:0009244" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:1842357" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000534 ; owl:annotatedTarget "A primary neuron (sensu Teleostei) that is neither a sensory neuron or a motor neuron." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000534 ; owl:annotatedTarget "ZFA:0009245" ; sssom:mapping_justification . [] obo:IAO_0000233 "https://github.com/obophenotype/cell-ontology/pull/1950" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000535 ; owl:annotatedTarget _:genid1949 . [] oboInOwl:hasDbXref "PMID:1842357", "doi:10.1242/dev.108.1.121" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000535 ; owl:annotatedTarget "A neuron of teleosts that develops later than a primary neuron, typically during the larval stages." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000535 ; owl:annotatedTarget "ZFA:0009246" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:1842357" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000536 ; owl:annotatedTarget "A secondary neuron (sensu Teleostei) that has a motor function." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000536 ; owl:annotatedTarget "ZFA:0009247" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:047125208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000537 ; owl:annotatedTarget "Obsolete. Use PO:0020093 from Plant Ontology instead. OBSOLETE, use term from plant ontology. A cell located at the chalazal end of the mature embryo sac in angiosperms." . [] oboInOwl:hasDbXref "TAIR:lr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000538 ; owl:annotatedTarget "Obsolete. Use PO:0000349 from Plant Ontology instead. A relatively unspecialized cell that will give rise to specialized cell types of the epidermis." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000006 ; owl:annotatedTarget "Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000539 ; owl:annotatedTarget "OBSOLETE: A cell in a tissue that markedly differs in form, size, or contents from other cells in the same tissue." . [] oboInOwl:hasDbXref "MESH:D009474", "http://en.wikipedia.org/wiki/Neuron" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000540 ; owl:annotatedTarget "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000540 ; owl:annotatedTarget "FBbt:00005106" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000540 ; owl:annotatedTarget "ZFA:0009248" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000541 ; owl:annotatedTarget "A cell that originates from the neural crest and differentiates into a pigment cell." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000541 ; owl:annotatedTarget "ZFA:0009249" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0683073696", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000542 ; owl:annotatedTarget "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000542 ; owl:annotatedTarget "ZFA:0009250" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000543 ; owl:annotatedTarget "Obsolete. Use PO:0000289 from Plant Ontology instead. One of the series of cellular components of a sieve tube. It shows a more or less pronounced differentiation between sieve plates (wide pores) and lateral sieve areas (narrow pores). Also sieve tube element and the obsolete sieve tube segment." . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "PMID:19022770", "http://en.wikipedia.org/wiki/Hematopoietic_stem_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000037 ; owl:annotatedTarget "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000545 ; owl:annotatedTarget obo:CL_0000492 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19375293", "PMID:20303875", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000545 ; owl:annotatedTarget "A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." . [] oboInOwl:hasDbXref "PMID:9419219" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000545 ; owl:annotatedTarget "T helper cells type 1" . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000545 ; owl:annotatedTarget "Th1 CD4+ T cell" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000037 ; owl:annotatedTarget "ZFA:0009014" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000546 ; owl:annotatedTarget obo:CL_0000492 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19375293", "PMID:20103781", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000546 ; owl:annotatedTarget "A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4." . [] oboInOwl:hasDbXref "PMID:9419219" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000546 ; owl:annotatedTarget "T helper cells type 2" . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000037 ; owl:annotatedTarget "HSC" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000038 ; owl:annotatedTarget obo:CL_0000839 . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000038 ; owl:annotatedTarget "A progenitor cell committed to the erythroid lineage." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000006 ; owl:annotatedTarget "ZFA:0009001" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000038 ; owl:annotatedTarget "ZFA:0009015" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000547 ; owl:annotatedTarget obo:CL_0000764 . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000038 ; owl:annotatedTarget "BFU-E" . [] oboInOwl:hasDbXref "ISBN:0721601464", "PMID:1638021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000547 ; owl:annotatedTarget "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000547 ; owl:annotatedTarget "rubriblast" . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000038 ; owl:annotatedTarget "CFU-E" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000549 ; owl:annotatedTarget obo:CL_0000765 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000549 ; owl:annotatedTarget "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000549 ; owl:annotatedTarget "ZFA:0005236" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000549 ; owl:annotatedTarget "basophilic normoblast" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000549 ; owl:annotatedTarget "early erythroblast" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000549 ; owl:annotatedTarget "early normoblast" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000549 ; owl:annotatedTarget "prorubricyte" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000039 ; owl:annotatedTarget "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000550 ; owl:annotatedTarget obo:CL_0000765 . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000550 ; owl:annotatedTarget "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000550 ; owl:annotatedTarget "ZFA:0005241" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000550 ; owl:annotatedTarget "intermediate erythroblast" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000550 ; owl:annotatedTarget "intermediate normoblast" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000550 ; owl:annotatedTarget "polychromatic erythroblast" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000550 ; owl:annotatedTarget "polychromatic normoblast" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000550 ; owl:annotatedTarget "polychromatophilic normoblast" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000039 ; owl:annotatedTarget "ZFA:0009016" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000550 ; owl:annotatedTarget "rubricyte" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000552 ; owl:annotatedTarget obo:CL_0000765 . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000552 ; owl:annotatedTarget "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000552 ; owl:annotatedTarget "acidophilic erythroblast" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000552 ; owl:annotatedTarget "eosinophilic erythroblast" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000552 ; owl:annotatedTarget "orthochromatic normoblast" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000552 ; owl:annotatedTarget "pyknotic eto enrythroblast" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000007 ; owl:annotatedTarget "A cell found in the embryo before the formation of all the gem layers is complete." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000553 ; owl:annotatedTarget obo:CL_0000839 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000553 ; owl:annotatedTarget "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." . [] oboInOwl:hasDbXref "PMID:11722431", "PMID:12482498" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000553 ; owl:annotatedTarget "CFU-Meg" . [] oboInOwl:hasDbXref "PMCID:PMC1794060" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000553 ; owl:annotatedTarget "Meg-CFC" . [] oboInOwl:hasDbXref "PMID:21116988" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000553 ; owl:annotatedTarget "MkP" . [] oboInOwl:hasDbXref "PMID:12482498" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000553 ; owl:annotatedTarget "megakaryocytic progenitor cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000554 ; owl:annotatedTarget "A peptide hormone secreting cell that secretes gastrin stimulating hormone." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000556 ; owl:annotatedTarget obo:CL_0000763 . [] oboInOwl:hasDbXref "ISBN:0721601464", "MESH:D008533", "PMID:31043076", "http://en.wikipedia.org/wiki/Megakaryocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000556 ; owl:annotatedTarget "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release." . [] oboInOwl:hasDbXref "GOC:amm", "GOC:dsd", "GOC:tfm", "GO_REF:0000031", "ISBN:0721601464", "MESH:D055014", "PMCID:PMC2213186", "PMCID:PMC548021", "PMID:16551251", "PMID:16647566", "http://en.wikipedia.org/wiki/CFU-GM", "http://www.copewithcytokines.de" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000557 ; owl:annotatedTarget "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." . [] oboInOwl:hasDbXref "DOI:10.1016/j.immuni.2017.10.021", "DOI:10.1146/annurev-immunol-081022113627", "DOI:10.1186/2050-7771-2-1" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000557 ; owl:annotatedTarget """Granulocyte monocyte progenitor cells (GMP cells), originating from hematopoietic stem cells in the bone marrow, are a critical intermediate in myeloid cell development. Positioned at a key differentiation juncture, these cells exhibit bidirectional potential, giving rise to both granulocyte and monocyte lineages. Their primary role is to generate mature granulocytes and monocytes, essential components of the body's innate immunity and inflammatory responses. Granulocytes, such as neutrophils, eosinophils, and basophils, contribute to the first line of defense against infections by migrating to the infection site and phagocytosing pathogens. Monocytes can differentiate into macrophages or dendritic cells, playing diverse roles in immune responses. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "http://www.copewithcytokines.de" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000557 ; owl:annotatedTarget "CFU-C , Colony forming unit in culture" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000557 ; owl:annotatedTarget "ZFA:0009251" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000557 ; owl:annotatedTarget "colony forming unit granulocyte macrophage" . [] oboInOwl:hasDbXref "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000557 ; owl:annotatedTarget "granulocyte-macrophage progenitor" . [] oboInOwl:hasDbXref "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000557 ; owl:annotatedTarget "CFU-GM" . [] oboInOwl:hasDbXref "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000557 ; owl:annotatedTarget "GMP" . [] a owl:Axiom ; rdfs:label "granulocyte monocyte progenitor cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000557 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000557" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000558 ; owl:annotatedTarget obo:CL_0000764 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "PMID:15946868", "PMID:2037622" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000558 ; owl:annotatedTarget "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000007 ; owl:annotatedTarget "ZFA:0009002" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000558 ; owl:annotatedTarget "ZFA:0009252" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000559 ; owl:annotatedTarget obo:CL_0002194 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000559 ; owl:annotatedTarget "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000559 ; owl:annotatedTarget "ZFA:0009253" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000040 ; owl:annotatedTarget obo:CL_0002194 . [] oboInOwl:hasDbXref "GOC:add", "PMID:1104740", "http://en.wikipedia.org/wiki/Monoblast", "http://www.copewithcytokines.de" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000040 ; owl:annotatedTarget "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000560 ; owl:annotatedTarget obo:CL_0000096 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0721601464", "PMID:10618520", "PMID:12560239", "PMID:15514007", "http://www.cap.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000560 ; owl:annotatedTarget "A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil. These cells are fMLP receptor-positive, CD11b-positive, CD35-negative, and CD49d-negative." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000560 ; owl:annotatedTarget "ZFA:0009254" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000040 ; owl:annotatedTarget "ZFA:0009017" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D025042", "WikipediaVersioned:Amacrine_cell&oldid=1023572246" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000561 ; owl:annotatedTarget "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000561 ; owl:annotatedTarget "ZFA:0009255" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "doi:10.1038/s41598-020-66092-9" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000561 ; owl:annotatedTarget "AC" . [] oboInOwl:hasDbXref "doi:10.1038/s41598-020-66092-9" ; oboInOwl:hasSynonymType obo:OMO_0003000, obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000561 ; owl:annotatedTarget "ACs" . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000040 ; owl:annotatedTarget "CFU-M" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000562 ; owl:annotatedTarget obo:CL_0000232 . [] oboInOwl:hasDbXref "GOC:add", "GOc:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000562 ; owl:annotatedTarget "An erythrocyte having a nucleus." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000562 ; owl:annotatedTarget "ZFA:0009256" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000563 ; owl:annotatedTarget "A rounded, inactive form that certain bacteria assume under conditions of extreme temperature, dryness, or lack of food. The bacterium develops a waterproof cell wall that protects it from being dried out or damaged." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000564 ; owl:annotatedTarget obo:CL_0000836 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0721601464", "PMID:12560239", "PMID:15514007" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000564 ; owl:annotatedTarget "A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000564 ; owl:annotatedTarget "ZFA:0009257" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000565 ; owl:annotatedTarget "A cell found in fat bodies whose primary function is intermediary metabolism." . [] oboInOwl:hasDbXref "ZFA:0007091", "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000008 ; owl:annotatedTarget "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000566 ; owl:annotatedTarget obo:CL_0000134 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "PMID:12768659" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000566 ; owl:annotatedTarget "A mesenchymal stem cell capable of developing into blood vessel endothelium." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000566 ; owl:annotatedTarget "ZFA:0009258" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000568 ; owl:annotatedTarget "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." . [] oboInOwl:hasDbXref "PMID:18816864" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000569 ; owl:annotatedTarget "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000569 ; owl:annotatedTarget "ZFA:0009259" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000570 ; owl:annotatedTarget obo:CL_0000710 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000570 ; owl:annotatedTarget "A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. This cell expresses a form of the neural cell adhesion molecule (N-CAM) on its surface and secretes calcitonin and serotonin (5-hydroxytryptamine)." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000570 ; owl:annotatedTarget "ZFA:0009260" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FMA:68653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000570 ; owl:annotatedTarget "C cell of thyroid gland" . [] oboInOwl:hasDbXref "FMA:68653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000570 ; owl:annotatedTarget "clear cell of thyroid gland" . [] oboInOwl:hasDbXref "FMA:68653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000570 ; owl:annotatedTarget "parafollicular cell of thyroid gland" . [] oboInOwl:hasDbXref "FMA:68653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000570 ; owl:annotatedTarget "thyroid parafollicular cell" . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000571 ; owl:annotatedTarget "A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000571 ; owl:annotatedTarget "ZFA:0009261" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "MESH:D017949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000573 ; owl:annotatedTarget "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000573 ; owl:annotatedTarget "ZFA:0009262" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "doi:10.1038/s41598-020-66092-9" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000573 ; owl:annotatedTarget "cone" . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000574 ; owl:annotatedTarget "A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000574 ; owl:annotatedTarget "ZFA:0009263" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000575 ; owl:annotatedTarget "An epithelial cell of the cornea." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000575 ; owl:annotatedTarget "ZFA:0009264" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FMA:70551" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000575 ; owl:annotatedTarget "epithelial cell of cornea" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000576 ; owl:annotatedTarget obo:CL_0000766 . [] oboInOwl:hasDbXref "GO_REF:0000031", "MESH:D009000" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000576 ; owl:annotatedTarget "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000576 ; owl:annotatedTarget "ZFA:0009265" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:9505449" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000577 ; owl:annotatedTarget "A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain)." . [] oboInOwl:hasDbXref "DOI:10.1016/0166-4328(96)00075-7", "DOI:10.1016/j.cell.2017.05.034", "DOI:10.1038/s41574-019-0168-8", "DOI:10.1073/pnas.1804938115" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000577 ; owl:annotatedTarget """Type EC enteroendocrine cells, also known as enterochromaffin cells, are a vital hormone-secreting cell type found in the gastrointestinal tract. These cells are named after their location in the intestines (“entero”) and because they are stainable by chromium salts (“chromaffin”). The primary function of type EC enteroendocrine cells is to act as chemosensors and lies in their capacity to produce and secrete serotonin, also known as 5-hydroxytryptamine (5-HT). Serotonin is a neurotransmitter that plays a significant role in modulating motility, secretion, vasodilation, perception of pain, and appetite in the gastrointestinal system. However, its function is not limited to the gastrointestinal tract; once secreted, serotonin is distributed via the bloodstream and contributes to regulating mood, appetite, and sleep in the brain. Via specific chemosensory receptors type EC enteroendocrine cells are able to respond to various environmental, metabolic, and homeostatic stimuli and transduce information from the gut to the nervous system: Food intake, particularly the ingestion of fats and carbohydrates, prompts these cells to produce and release serotonin; the mechanical stimulus of food in the lumen can also trigger release. The distribution, function, and responsiveness of type EC cells reveal them as a crucial link between the intestinal environment, the nervous system, and the regulation of numerous bodily functions. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "type EC enteroendocrine cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000577 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000577" . [] oboInOwl:hasDbXref "FB:ma", "ReO:mhb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000578 ; owl:annotatedTarget "A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure." . [] oboInOwl:hasDbXref "FBbt:00004905" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000579 ; owl:annotatedTarget "A follicle cell that migrates from the anterior pole of the insect egg chamber to the anterior of the oocyte where they participate in the formation of the micropyle." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000579 ; owl:annotatedTarget "FBbt:00004905" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000008 ; owl:annotatedTarget "ZFA:0007091" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000580 ; owl:annotatedTarget obo:CL_0000776 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0721601464", "PMID:10618520", "PMID:12560239", "PMID:15514007", "http://www.cap.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000580 ; owl:annotatedTarget "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. This cell type is CD13-positive, CD16-negative, integrin alpha-M-positive, CD15-positive, CD33-positive, CD24-positive, C/EBP-a-positive, C/EBPe-positive, PU.1-positive, lactotransferrin-positive, myeloperoxidase-positive and NGAL-positive." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000580 ; owl:annotatedTarget "ZFA:0009266" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000581 ; owl:annotatedTarget obo:CL_0000864 . [] oboInOwl:hasDbXref "MESH:D017737", "PMID:15771589", "PMID:19201820" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000581 ; owl:annotatedTarget "A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000581 ; owl:annotatedTarget "ZFA:0009267" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000009 ; owl:annotatedTarget "Obsolete. Use PO:0000079 from Plant Ontology instead. An elongated cell with approximately wedge-shaped ends, found in the vascular cambium, which gives rise to the elements of the axial system in the secondary vascular tissues." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000582 ; owl:annotatedTarget obo:CL_0000776 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0721601464", "PMID:10618520", "PMID:12560239", "PMID:15514007", "http://www.cap.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000582 ; owl:annotatedTarget "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000582 ; owl:annotatedTarget "ZFA:0009268" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000583 ; owl:annotatedTarget obo:CL_0000864 . [] oboInOwl:hasDbXref "GOC:ana", "GOC:dsd", "GOC:tfm", "GO_REF:0000031", "MESH:D016676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000583 ; owl:annotatedTarget "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative." . [] oboInOwl:hasDbXref "DOI:10.1007/s00424-017-1965-3", "DOI:10.1016/j.cellimm.2018.01.005", "DOI:10.1038/nri3600", "DOI:10.14348/molcells.2021.0058" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000583 ; owl:annotatedTarget """Alveolar macrophages are unique tissue-resident macrophages found in the lungs, specifically in the air sacs or alveoli where gas exchange occurs. They are characterized by specific surface markers including: F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative. These specialized immune cells form a crucial part of the body's defense mechanism, playing important roles in pulmonary health and homeostasis. They are the first line of defense in the pulmonary immune response, acting as scavengers that patrol the alveoli and engulf foreign particles like bacteria, dust, and other debris that enter the lungs through inhalation. The primary function of these alveolar macrophages is phagocytosis, whereby they consume and digest foreign substances, dead cells, and other particulates. In the lung, alveolar macrophages are also responsible for clearing surfactant. Additionally, alveolar macrophages also play an integral role in initiating the immune response, as they secrete several pro-inflammatory cytokines and chemokines that recruit other immune cells to the site of infection or inflammation. Beyond their role in host defense, alveolar macrophages contribute to tissue remodeling and wound repair in the lungs, aiding in maintaining lung integrity. They also regulate local inflammation and control the immune response to prevent excessive inflammation that may be harmful. However, an imbalance in the function of alveolar macrophages can contribute to various lung diseases. Abnormal alveolar macrophage activation has been implicated in chronic inflammatory diseases such as emphysema, asthma, and fibrosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0000583 ; owl:annotatedTarget "The marker set MSR1, FABP4 can identify the Human cell type alveolar macrophage in the lung with a confidence of 0.80 (NS-Forest FBeta value)." . [] a owl:Axiom ; rdfs:label "alveolar macrophage on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000583 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000583" . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000584 ; owl:annotatedTarget "An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000584 ; owl:annotatedTarget "ZFA:0009269" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:33290721", "https://orcid.org/0000-0001-9610-7627" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_0000584 ; owl:annotatedTarget "differentiated enterocyte" . [] oboInOwl:hasDbXref "PMID:33290721", "https://orcid.org/0000-0001-9610-7627" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_0000584 ; owl:annotatedTarget "mature enterocyte" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000586 ; owl:annotatedTarget obo:CL_0000039 . [] oboInOwl:hasDbXref "MESH:D005854" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000586 ; owl:annotatedTarget "The reproductive cell in multicellular organisms." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000587 ; owl:annotatedTarget "A thermoreceptor cell that detects reduced temperatures." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000588 ; owl:annotatedTarget obo:CL_0000092 . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000588 ; owl:annotatedTarget "A specialized osteoclast associated with the absorption and removal of cementum." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000588 ; owl:annotatedTarget "ZFA:0009270" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "MESH:D006199" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000589 ; owl:annotatedTarget "A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated." . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D008184" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000590 ; owl:annotatedTarget "A progesterone secreting cell in the corpus luteum that develops from theca cells." . [] oboInOwl:hasDbXref "GOC:tfm", "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000591 ; owl:annotatedTarget "A thermoreceptor cell that detects increased temperatures." . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D008184" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000592 ; owl:annotatedTarget "A large, progesterone secreting cell in the corpus luteum that develops from the granulosa cells." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000593 ; owl:annotatedTarget "A steroid hormone secreting cell that secretes androgen." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000593 ; owl:annotatedTarget "ZFA:0009271" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D032496", "PMID:21849021", "PMID:23303905" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000594 ; owl:annotatedTarget "An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers." . [] oboInOwl:hasDbXref "DOI:10.1016/s1357-2725(03)00042-6", "DOI:10.1152/physrev.00061.2017", "DOI:10.1186/s13287-022-02706-5", "DOI:10.1369/0022155411426780", "DOI:10.22074/cellj.2016.4714" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000594 ; owl:annotatedTarget """Skeletal muscle satellite cells (SMSCs) are a type of adult stem cell that nestles on the outer surface of the myofiber, positioned between the sarcolemma (plasma membrane of the muscle cell) and peripheral basement membrane. The primary function of SMSCs lies in their capacity to facilitate the growth and repair of damaged skeletal muscle. Upon muscle injury or trauma, these normally quiescent cells activate, proliferate, and differentiate into myoblasts. These myoblasts subsequently mature and fuse to form myotubes, which ultimately help in the repair and rebuilding of muscle fibers. This response is an integral part of the skeletal muscle's ability to recover from injury and adapt to enhanced or changing physical demands, thereby maintaining and improving muscle function. Furthermore, SMSCs also contribute to hypertrophic muscle growth due to resistance exercise and endurance training, with the notable feature of their multi-nucleated nature resulting from the fusion of differentiated myoblasts. The additional nuclei support enhanced protein synthesis, thus allowing the muscle fibers to grow and strengthen in response to exercise. In aging and in diseases, the number or functionality of these cells can decrease, leading to impaired muscle regeneration and progressive muscle weakness. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "ReO:mhb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000010 ; owl:annotatedTarget "A cell in vitro that is or has been maintained or propagated as part of a cell culture." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000594 ; owl:annotatedTarget "ZFA:0009272" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "skeletal muscle satellite cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000594 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000594" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000595 ; owl:annotatedTarget obo:CL_0000232 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000595 ; owl:annotatedTarget "An erythrocyte lacking a nucleus." . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000595 ; owl:annotatedTarget "RBC" . [] oboInOwl:hasDbXref "FAO:0000017", "GOC:tfm", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000596 ; owl:annotatedTarget "A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0471940526", "PMID:8357339", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000597 ; owl:annotatedTarget "The smaller of two types of asexual spores formed by some fungi. An ovoid to pear-shaped asexual spore that contains very little cytoplasm and organelles, is uninucleate, and forms in vegetative hypae within a mycelium. Micronidia are extruded from the hyphal cell wall." . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D017966" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000598 ; owl:annotatedTarget "Pyramidal neurons have a pyramid-shaped soma with a single axon, a large apical dendrite and multiple basal dendrites. The apex and an apical dendrite typically point toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000598 ; owl:annotatedTarget "ZFA:0009273" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:08199377X", "PMID:2524423", "PMID:9529886", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000599 ; owl:annotatedTarget "An asexual, nonmotile spore formed by higher fungi; conidia are usually made from the side or tip of specialized sporogenous cells and do not form by progressive cleavage of the cytoplasm." . [] oboInOwl:hasDbXref "ISBN:08199377X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000600 ; owl:annotatedTarget "A fungal cell with two or more genetically distinct nuclei." . [] oboInOwl:hasDbXref "MESH:D018072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000601 ; owl:annotatedTarget "A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea." . [] oboInOwl:hasDbXref "MESH:D011311" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000602 ; owl:annotatedTarget "A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000602 ; owl:annotatedTarget "ZFA:0009274" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:08199377X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000603 ; owl:annotatedTarget "A fungal cell with two genetically distinct haploid nuclei." . [] oboInOwl:hasDbXref "MESH:D017948" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000604 ; owl:annotatedTarget "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000604 ; owl:annotatedTarget "ZFA:0009275" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "doi:10.1038/s41598-020-66092-9" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000604 ; owl:annotatedTarget "rod" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:2524423", "PMID:9529886", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000605 ; owl:annotatedTarget "A spore formed following mitosis or mitoses." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0471940526", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000606 ; owl:annotatedTarget "The larger of two types of asexual spores formed by some fungi; usually round or oblong." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:08199377X", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000607 ; owl:annotatedTarget "A thick walled spore that stores and protects one or more nuclei following sexual reproduction in an Ascomycete." . [] oboInOwl:hasDbXref "ISBN:0471940526", "ISBN:08199377X", "SGD:clt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000608 ; owl:annotatedTarget "A thick walled, sexual, resting spore formed by Zygomycetes; sometimes refers to the spore and the multi-layered cell wall that encloses the spore, the zygosporangium." . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D018069" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000609 ; owl:annotatedTarget "A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem." . [] oboInOwl:hasDbXref "ZFA:0007095", "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000011 ; owl:annotatedTarget "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000611 ; owl:annotatedTarget obo:CL_0002191 . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000611 ; owl:annotatedTarget "Any granulocytopoietic cell that has part some transcription factor PU.1 and has part some CCAAT/enhancer-binding protein alpha and has part some erythroid transcription factor and lacks plasma membrane part some CD19 molecule and lacks plasma membrane part some CD4 molecule and lacks plasma membrane part some integrin alpha-M and lacks plasma membrane part some CD3 epsilon and lacks plasma membrane part some neural cell adhesion molecule 1 and lacks plasma membrane part some CD2 molecule and lacks plasma membrane part some T-cell surface glycoprotein CD8 alpha chain and lacks plasma membrane part some membrane-spanning 4-domains subfamily A member 1 and lacks plasma membrane part some T-cell surface glycoprotein CD5 and lacks plasma membrane part some CD14 molecule and lacks plasma membrane part some lymphocyte antigen 6G and lacks plasma membrane part some lymphocyte antigen 76 (mouse) and has plasma membrane part some CD34 molecule and has plasma membrane part some ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 and has plasma membrane part some interleukin-3 receptor class 2 alpha chain and has plasma membrane part some interleukin-5 receptor subunit alpha and has plasma membrane part some mast/stem cell growth factor receptor and is capable of some eosinophil differentiation." . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000611 ; owl:annotatedTarget "CFU-Eo" . [] oboInOwl:hasDbXref "PMCID:PMC2212039", "PMCID:PMC2626675" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000611 ; owl:annotatedTarget "EoP" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000041 ; owl:annotatedTarget obo:CL_0000771 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0721601464", "http://www.cap.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000041 ; owl:annotatedTarget "A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000612 ; owl:annotatedTarget obo:CL_0000772 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "ISBN:0721601464", "PMID:19622087", "http://www.cap.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000612 ; owl:annotatedTarget "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000613 ; owl:annotatedTarget obo:CL_0002191 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "PMCID:PMC1312421", "http://www.copewithcytokines.de" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000613 ; owl:annotatedTarget "A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000011 ; owl:annotatedTarget "ZFA:0007095" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000614 ; owl:annotatedTarget obo:CL_0000768 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0721601464", "PMID:18466030", "http://www.cap.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000614 ; owl:annotatedTarget "A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive." . [] oboInOwl:hasDbXref "GOC:clt", "ISBN:0471940526", "ISBN:08199377X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000615 ; owl:annotatedTarget "A thick walled spore containing one or more haploid nuclei produced by sexual reproduction in an Basidiomycete; formed externally on extrusions of the basidium." . [] oboInOwl:hasDbXref "ISBN:08199377X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000616 ; owl:annotatedTarget "OBSOLETE: A walled spore produced in a sporangium." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000617 ; owl:annotatedTarget "A neuron that uses GABA as a vesicular neurotransmitter" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000617 ; owl:annotatedTarget "FBbt:00007228" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000617 ; owl:annotatedTarget "ZFA:0009276" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:08199377X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000620 ; owl:annotatedTarget "OBSOLETE: A sporangiospore that is motile, having flagella." . [] oboInOwl:hasDbXref "PMID:22274696" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000621 ; owl:annotatedTarget "A myoblast that is committed to a myotube-specific program of differentiation but not yet fused. It undergoes very limited additional proliferation. After fusion, it will take on a muscle identity specified by a `muscle founder cell` (CL:0008006)." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.copewithcytokines.de" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000622 ; owl:annotatedTarget "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." . [] oboInOwl:hasDbXref "DOI:10.1007/BF00710764", "DOI:10.1038/nrgastro.2013.36", "DOI:10.1097/MOG.0b013e32832ebfac", "DOI:10.1111/prd.12116", "DOI:10.1152/physrev.00011.2011" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000622 ; owl:annotatedTarget """Acinar cells are specialized exocrine gland cells that secrete specific enzymes and fluids to aid in digestion. Found primarily in the pancreas and salivary glands, the term acinar is derived from the Latin word 'acinus' which means 'grape'; this is because acinar cells are arranged in a grape-like cluster around small ducts, formulating an acinus structure. In the salivary glands, acinar cells secrete digestive enzymes as well as other substances such as mucus and water. These secretions service the initial stages of the digestive process, preparing the consumed food for onward digestion in the stomach and intestines by lubricating and partially breaking it down. In the pancreas, acinar cells are responsible for synthesizing and secreting a significant amount of digestive enzymes, such as trypsin, chymotrypsin, and amylase. These enzymes are stored in zymogen granules inside the acinar cells until they are dispatched into the small intestine. Once within the small intestine, they break down proteins, carbohydrates, and fats into substances that can be absorbed. This is vital to the effective and efficient digestion and absorption of nutrients from the food we consume. Acinar cells have high protein synthesis rates and are susceptible to accumulation of misfolded proteins; the subsequential induction of ER stress is thought to be involved in the development of pancreatitis, a serious inflammatory disease of the exocrine pancreas. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000622 ; owl:annotatedTarget "ZFA:0009277" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "acinar cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000622 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000622" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:15771571" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000623 ; owl:annotatedTarget "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000623 ; owl:annotatedTarget "ZFA:0009278" ; sssom:mapping_justification . (obo:CL_0000791 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] ) . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000624 ; owl:annotatedTarget obo:CL_0000791 . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000624 ; owl:annotatedTarget "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000625 ; owl:annotatedTarget obo:CL_0000791 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000625 ; owl:annotatedTarget "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." . [] oboInOwl:hasDbXref "GOC:mah", "doi:10.1038/s41598-018-27692-8" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000626 ; owl:annotatedTarget "A granule cell that has a soma located in an olfactory bulb granule cell layer. An olfactory granule cell is an interneuron that lacks an axon, makes reciprocal dendro-dendritic synapses with mitral cells and tufted cells and is involved in the fine spatio-temporal tuning of the responses of these principal olfactory bulb neurons to odors." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000626 ; owl:annotatedTarget "ZFA:0001694" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "doi:10.1038/s41598-018-27692-8" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000626 ; owl:annotatedTarget "olfactory bulb granule cell" . [] oboInOwl:hasDbXref "doi:10.1038/s41598-018-27692-8" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0000626 ; owl:annotatedTarget "Granule cells are the most abundant neuronal population in the olfactory bulb and are continuously renewed throughout life." . [] oboInOwl:hasDbXref "TAIR:sr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000627 ; owl:annotatedTarget "OBSOLETE. A cell involved in transporting nutrients, minerals, water, gases and other chemicals between cells for a variety of purposes including conveying nutrition to other tissues, removing waste products from the tissues, conveying gases for respiration, distributing heat and repelling invasion of foreign substances." . [] oboInOwl:hasDbXref "TAIR:sr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000628 ; owl:annotatedTarget "A cell that can perform photosynthesis, in which carbohydrates are synthesized from carbon dioxide and water, using light as the energy source." . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000629 ; owl:annotatedTarget "A cell that is specialized to store a particular substance(s), which is(are) later released from the store for a particular purpose." . [] oboInOwl:hasDbXref "FB:ma", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000630 ; owl:annotatedTarget "A cell whose primary function is to support other cell types." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000630 ; owl:annotatedTarget "ZFA:0009387" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "MESH:D007760" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000631 ; owl:annotatedTarget "Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen." . [] oboInOwl:hasDbXref "GOC:dsd", "MESH:D055166", "PMID:12808230", "PMID:17239632", "PMID:18222966", "PMID:9302568", "http://en.wikipedia.org/wiki/Hepatic_stellate_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000632 ; owl:annotatedTarget "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000632 ; owl:annotatedTarget "ZFA:0009279" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:12808230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000632 ; owl:annotatedTarget "vitamin A-storing cells" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM889.CJPK.447" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000632 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000633 ; owl:annotatedTarget "A tall supporting cell that is arranged in rows adjacent to the last row of outer phalangeal cells. This cell type constitutes the outer border of the organ of Corti." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000634 ; owl:annotatedTarget "A cuboidal cell which along with Boettcher's cells form the floor of the external spiral sulcus, external to the organ of Corti." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544", "http://www.britannica.com/EBchecked/topic/156177/Deiters-cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000635 ; owl:annotatedTarget "The outer phalangeal cells of the organ of Corti. This cell holds the base of the hair cell in a cup-shaped depression." . [] oboInOwl:hasDbXref "GOC:NV", "PMID:21911394" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000636 ; owl:annotatedTarget "Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000636 ; owl:annotatedTarget "ZFA:0009280" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "doi:10.21769/BioProtoc.4179" ; oboInOwl:hasSynonymType core:MISSPELLING ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000636 ; owl:annotatedTarget "Muller cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000042 ; owl:annotatedTarget obo:CL_0000835 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000637 ; owl:annotatedTarget "A cell that stains readily in the anterior pituitary gland." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000638 ; owl:annotatedTarget "An acidophilic chromophil cell that of the anterior pituitary gland." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000639 ; owl:annotatedTarget "A basophilic chromophil cell that of the anterior pituitary gland." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000641 ; owl:annotatedTarget "A cell that is resistant to stains." . [] oboInOwl:hasDbXref "JB:jb", "PMID:10495875", "PMID:15961560", "doi:10.23937/2572-407X.1510006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000642 ; owl:annotatedTarget "An agranular supporting cell of the anterior pituitary (adenohypophysis) that is characterized by a star-like morphology and ability to form follicles. Folliculostellate cells communicate with each other and with endocrine cells via gap junctions." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000642 ; owl:annotatedTarget "ZFA:0009281" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "doi:10.23937/2572-407X.1510006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000642 ; owl:annotatedTarget "folliculo-stellate cell" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464", "PMID:12560239", "PMID:15514007" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000042 ; owl:annotatedTarget "A myeloblast committed to the neutrophil lineage. This cell type is GATA-1 positive, C/EBPa-positive, AML-1-positive, c-myb-positive and has low expression of PU.1 transcription factor." . [] oboInOwl:hasDbXref "PMID:34734454" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000642 ; owl:annotatedTarget "pituitary folliculostellate cell" . [] oboInOwl:hasDbXref "PMID:34734454" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000642 ; owl:annotatedTarget "FS cell" . [] oboInOwl:hasDbXref "doi:10.23937/2572-407X.1510006" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000642 ; owl:annotatedTarget "FSC" . [] oboInOwl:hasDbXref "PMID:34734454" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000642 ; owl:annotatedTarget "Sox2-positive stem cell" . [] oboInOwl:hasDbXref "PMID:18287078", "PMID:31620083", "PMID:34734454", "doi:10.23937/2572-407X.1510006" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0000642 ; owl:annotatedTarget "Folliculostellate cells are a heterogeneous group of cells rather than a single cell type, with different morphology and gene expression profiles. Due to this heterogeneity, it is unclear if different properties that have been attributed to folliculostellate cells (pluripotent, proliferative, phagocytic) are common in all folliculostellate cells or limited to particular subsets." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.neurolex.org/wiki/Category:Bergmann_Glial_Cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000644 ; owl:annotatedTarget "Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000644 ; owl:annotatedTarget "ZFA:0009282" ; sssom:mapping_justification . [] dc:license ; oboInOwl:hasDbXref "doi:10.3389/fnins.2020.00293" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000644 ; owl:annotatedTarget . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000042 ; owl:annotatedTarget "ZFA:0009018" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:0412046911", "ISBN:0517223651", "PMID:31915267", "http://en.wikipedia.org/wiki/Pituicyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000645 ; owl:annotatedTarget "A glial cell of astrocytic lineage with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000646 ; owl:annotatedTarget "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000647 ; owl:annotatedTarget obo:CL_0000766 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0702022918", "ISBN:0702024783", "PMID:33348900", "Wikipedia:Giant_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000647 ; owl:annotatedTarget "A phagocytic syncytial cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes." . [] oboInOwl:hasDbXref "ISBN:0702022918", "ISBN:0702024783" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000647 ; owl:annotatedTarget "Langerhans giant cell" . [] oboInOwl:hasDbXref "ISBN:0702022918", "ISBN:0702024783" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000647 ; owl:annotatedTarget "foreign body giant cell" . [] oboInOwl:hasDbXref "ISBN:0702022918", "ISBN:0702024783" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000647 ; owl:annotatedTarget "macrophage polykaryon" . [] oboInOwl:hasDbXref "ISBN:0702022918", "ISBN:0702024783" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000647 ; owl:annotatedTarget "multinucleate giant cell" . [] oboInOwl:hasDbXref "ISBN:0702022918", "ISBN:0702024783" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000647 ; owl:annotatedTarget "syncytial giant cell" . [] oboInOwl:hasDbXref "PMID:33348900" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000647 ; owl:annotatedTarget "MGC" . [] oboInOwl:hasDbXref "GOC:cvs", "GOC:tfm", "PMID:11457727" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000648 ; owl:annotatedTarget "A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000648 ; owl:annotatedTarget "ZFA:0005238" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544", "ISBN:0815332181", "PMID:21860392", "PMID:32097634", "WIKIPEDIA:Spinous_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000649 ; owl:annotatedTarget "A keratinocyte found within the stratum spinosum (prickle cell layer) of the epidermis, distinguished by numerous intercellular desmosomes, which give it a “prickly” or spiny appearance. Positioned above the mitotically active basal layer and beneath the granular layer, it contributes to the skin’s mechanical strength and barrier function, preventing water loss and pathogen entry. This cell expresses differentiation-specific keratins K1 and K10 in mice, unlike basal cells that express K5 and K14, and lacks the keratohyalin granules found in granular cells, marking its intermediate stage of epidermal differentiation." . [] oboInOwl:hasDbXref "WIKIPEDIA:Spinous_cell" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000649 ; owl:annotatedTarget "prickle cell of epidermis" . [] oboInOwl:hasDbXref "PMID:32843640" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000649 ; owl:annotatedTarget "spinous keratinocytes of epidermis" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM642.BMZS.772" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000649 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-epidermal-ridge/v1.2/assets/2d-ftu-skin-epidermal-ridge.png" . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.copewithcytokines.de/cope.cgi?key=mesangial%20cells" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000650 ; owl:annotatedTarget "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000650 ; owl:annotatedTarget "ZFA:0009283" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000651 ; owl:annotatedTarget "OBSOLETE. A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "PMID:16687276", "http://en.wikipedia.org/wiki/Pinealocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000652 ; owl:annotatedTarget "This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000652 ; owl:annotatedTarget "ZFA:0009284" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "https://doi.org/10.1101/2021.10.10.463829" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000653 ; owl:annotatedTarget "A specialized kidney epithelial cell, contained within a glomerulus, that contains \"feet\" that interdigitate with the \"feet\" of other podocytes." . [] oboInOwl:hasDbXref "DOI:10.1038/s41467-022-33748-1", "DOI:10.1038/s41572-020-0196-7", "DOI:10.1146/annurev-physiol-020911-153238", "DOI:10.1159/000481633", "DOI:10.3389/fcell.2021.771931" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000653 ; owl:annotatedTarget """Podocytes are highly specialized, terminally differentiated glomerular visceral epithelial cells that wrap around the capillaries in the kidneys. They play an essential role in kidney function, particularly in the filtration selectivity of the glomerulus. Each podocyte is characterized by a unique architecture with a large cell body, ‘major processes’ extending outwardly from the cell body and ‘foot processes’, also known as pedicels, which surround. the glomerular capillary loops Podocytes represent the last barrier of the glomerular filtration membrane in the kidney. This barrier prevents the leakage of plasma proteins from the blood into the urine, hence maintaining protein homeostasis in the body. The foot processes of the podocytes interdigitate with those from neighboring cells. The cell-cell junctions between the foot processes, the slit-diaphragms, are thought to create a molecular sensor of renal filtration that prevents the passage of macromolecules while allowing water and small solutes to pass. Podocytes also contribute to the glomerular basement membrane by secreting collagen and maintain glomerular endothelial cell fenestration by secreting VEGFA. They have been shown to play a role in inducing cytoskeletal regulation, cell adhesion, and inflammatory response, consistent with their essential function in the kidney. The importance of podocytes is further emphasized by the effects of their damage or loss. Abnormalities in podocytes often result in severe kidney diseases (podocytopathies), including focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD). Injury to the podocytes can result in \"effacement\" or flattening of foot processes, leading to increased permeability of the filtration barrier and proteinuria (an excess of serum protein in urine) which is a common symptom of kidney diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "FMA:70967" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000653 ; owl:annotatedTarget "epithelial cell of visceral layer of glomerular capsule" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000653 ; owl:annotatedTarget "ZFA:0009285" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FMA:70967" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000653 ; owl:annotatedTarget "glomerular podocyte" . [] a owl:Axiom ; rdfs:label "podocyte on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000653 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000653" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM778.SHGJ.294" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000653 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000654 ; owl:annotatedTarget obo:CL_0000023 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000654 ; owl:annotatedTarget "A primary oocyte is an oocyte that has not completed female meosis I." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000655 ; owl:annotatedTarget obo:CL_0000023 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000655 ; owl:annotatedTarget "A secondary oocyte is an oocyte that has not completed meiosis II." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000656 ; owl:annotatedTarget "A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000657 ; owl:annotatedTarget "One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000657 ; owl:annotatedTarget "FBbt:00004941" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000658 ; owl:annotatedTarget "An epithelial cell that secretes cuticle." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000659 ; owl:annotatedTarget "An extracellular matrix secreting cell that secretes eggshell." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000660 ; owl:annotatedTarget "An extracellular matrix secreting cell that secretes glycocalyx." . [] oboInOwl:hasDbXref "DOI:10.1007/978-3-211-99390-3_133" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000666 ; owl:annotatedTarget "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues." . [] oboInOwl:hasDbXref "DOI:10.1002/ar.1092200109", "DOI:10.1016/0306-4522(86)90162-4", "DOI:10.1016/j.devcel.2012.11.003", "DOI:10.1038/s41467-022-31571-2", "DOI:10.1152/ajprenal.90601.2008" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000666 ; owl:annotatedTarget """Fenestrated cells are specialized epithelial cells that are characterized by a distinctive structural feature, fenestrations or tiny pores, which allow an exchange of substances such as fluids, nutrients, and waste between blood vessels and the surrounding tissue environments. These cells are present in various types of epithelial tissues in the human body, including the intestinal tract, endocrine glands, and certain parts of the renal system. There are multiple types of endothelial cell fenestrations. The most common type is found in systemic capillaries of the endocrine tissue (e.g., pancreatic islets), gastrointestinal mucosa, and renal peritubular capillaries. Here, the fenestrated cells have fenestrations in their peripheral cytoplasm with a unique thin and permeable diaphragm that provides a high degree of selectivity, blocking the passage of larger molecules while allowing the free movement of smaller ones. In contrast, other types of fenestrations, such as the discontinuous epithelium of the liver sinusoidal endothelial cells, do not have diaphragms. Characteristically, fenestrated cells play a vital role in the filtering process of body systems. They are a key part of the glomeruli in the kidneys where blood is filtered under high pressure. The fenestrations present in the endothelial cells lining the capillaries of the glomerulus allow the free passage of water and small solute molecules towards the Bowman's capsule, leaving behind larger proteins and cells in the blood, thereby aiding in the filtration and waste removal process. In the endocrine system, fenestrated cells in glandular capillaries allow the prompt release of hormones into the bloodstream. These cells have tightly clustered fenestrations which increase the surface area available for passive diffusion, improving the efficiency of hormone secretion. In villi of the small intestine, these cells increase absorption efficiency, permitting the exchange of water, electrolytes, and nutrients. Overall, fenestrated cells contribute immensely to important physiological processes of filtration, absorption, and secretion, primarily connecting our body's circulation system with the surrounding tissues and organs. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000666 ; owl:annotatedTarget "ZFA:0009286" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "fenestrated endothelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000666 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000666" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000667 ; owl:annotatedTarget "An extracellular matrix secreting cell that secretes collagen." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000667 ; owl:annotatedTarget "ZFA:0009287" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000668 ; owl:annotatedTarget "OBSOLETE: The cell characteristic of an organ, as distinguished from associated connective or supporting tissues." . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "ISBN:0721662544", "MESH:D020286", "PMID:16807374", "PMID:17986482", "PMID:20024907" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000669 ; owl:annotatedTarget "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000669 ; owl:annotatedTarget "ZFA:0009112" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:17986482" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000669 ; owl:annotatedTarget "ARC" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000670 ; owl:annotatedTarget obo:CL_0000039 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000670 ; owl:annotatedTarget obo:CL_0000219 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:1381289" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000670 ; owl:annotatedTarget "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000670 ; owl:annotatedTarget "ZFA:0009288" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:36807509" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000671 ; owl:annotatedTarget "A follicle cell that migrates from the dorso-anterior part of the oocyte associated follicular epithelium, in between the nurse cells and the oocyte, and participates in the formation of the operculum." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000671 ; owl:annotatedTarget "FBbt:00004906" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000672 ; owl:annotatedTarget "Obsolete. Use PO:0000290 from Plant Ontology instead. A water conducting cell, tracheid or vessel member." . [] oboInOwl:hasDbXref "doi:10.1016/S1467-8039(03)00009-4" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000673 ; owl:annotatedTarget "An intrinsic neuron of the mushroom body of arthropods and annelids. They have tightly packed, cytoplasm-poor cell bodies." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000673 ; owl:annotatedTarget "FBbt:00003686" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:36531940" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000674 ; owl:annotatedTarget "A follicle cell that is part of the stalk connecting adjacent egg chambers." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000674 ; owl:annotatedTarget "FBbt:00004910" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000675 ; owl:annotatedTarget obo:CL_0000021 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000675 ; owl:annotatedTarget "A mature sexual reproductive cell of the female germline." . [] oboInOwl:hasDbXref "JB:jb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000677 ; owl:annotatedTarget "Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000677 ; owl:annotatedTarget "ZFA:0009289" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:17560562", "PMID:31693445" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000678 ; owl:annotatedTarget "A neuron with soma location in the central nervous system that project its axon to the contralateral side of a central nervous system. This neuron can have its soma in the spinal cord, in the hemisphere of the brain, in the retina or in the ventral nerve cord of invertebrates." . [] oboInOwl:hasDbXref "PMID:25960414", "PMID:27532244", "PMID:31514748", "PMID:33438755" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0000678 ; owl:annotatedTarget "Historically, commissural neurons, particularly in the spinal cord, have been used as a model to understand axon guidance during development." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000679 ; owl:annotatedTarget "FBbt:00100291" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000679 ; owl:annotatedTarget "ZFA:0009290" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000680 ; owl:annotatedTarget "A non-terminally differentiated cell that is capable of developing into a muscle cell." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000680 ; owl:annotatedTarget "ZFA:0009291" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000681 ; owl:annotatedTarget "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000681 ; owl:annotatedTarget "ZFA:0009292" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:jb", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000682 ; owl:annotatedTarget "An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes." . [] oboInOwl:hasDbXref "DOI:10.1038/nature08529", "DOI:10.1093/jb/mvv121", "DOI:10.1136/gut.47.5.735", "https://www.ncbi.nlm.nih.gov/books/NBK534232/", "https://www.sciencedirect.com/topics/medicine-and-dentistry/microfold-cell" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000682 ; owl:annotatedTarget """M cells, or microfold cells, of the gut are specialized epithelial cells found in the lining of the gut, specifically in the follicle-associated epithelium of mucosa-associated lymphoid tissue, where they function as sentries against toxins and pathogens. M cells are characterized by apical microfolds (hence their alternate name) which express unique adhesion molecules that enable them to sample the luminal macromolecules. Other morphological features that distinguish M cells from other intestinal mucosal cells include sparse microvilli and a reduced thickness of the glycocalyx, which permits adhesion while not hindering the transport of molecules. They also have unique intraepithelial invaginations on the basolateral side which are filled with macrophages and other immune cells that can process the engulfed macromolecules quickly. These morphological characteristics enable M cells to serve a dual role in immune responses. They initiate the immune response by transporting antigens (such as toxic or pathogenic substances) across the epithelial layer to lymphocytes and antigen-presenting cells in the underlying lymphoid tissue. This specialized transport process is called 'transcytosis.' They also have specialized molecules like glycoprotein-2 for bacterial uptake. Simultaneously, M cells help maintain immune tolerance to food antigens and commensal bacteria, preventing unnecessary reactions to non-pathogenic substances and hypersensitivity conditions. While these functions are crucial for well-being, M cell dysfunction can lead to serious conditions like Crohn's disease and other inflammatory bowel diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000682 ; owl:annotatedTarget "ZFA:0009293" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "M cell of gut on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000682 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000682" . [] oboInOwl:hasDbXref "JB:jb", "http://neurolex.org/wiki/Category:Ependymoglial_Cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000683 ; owl:annotatedTarget "A cell that transports hormones from neurosecretory cells. This nerve cell is characterized by bipolar shape and endfeet that contact a basal lamina around blood vessels, and/or the pia mater or vitreous body of the eye and additionally contact the ventricular surface or sub-retinal space." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000683 ; owl:annotatedTarget "ZFA:0009294" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PO:0004010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000685 ; owl:annotatedTarget "Obsolete. Use PO:0004010 from Plant Ontology instead. A cell synthesizing protoplasm and producing new cells by division and with only a primary cell wall." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000686 ; owl:annotatedTarget "A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000686 ; owl:annotatedTarget "ZFA:0009295" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000687 ; owl:annotatedTarget "FBbt:00004213" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "JB:jb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000688 ; owl:annotatedTarget "A fibroblast-like cell that provides support at neuromuscular junctions in vertebrates and are localized outside the synaptic basal lamina." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000688 ; owl:annotatedTarget "ZFA:0009296" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "JB:jb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000689 ; owl:annotatedTarget "A cell with both myofibrils and secretory granules." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000690 ; owl:annotatedTarget "FBbt:00004215" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000691 ; owl:annotatedTarget "Any interneuron that has characteristic some stellate morphology." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000691 ; owl:annotatedTarget "ZFA:0009297" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "JB:jb", "PMID:16136171" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000692 ; owl:annotatedTarget "A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000692 ; owl:annotatedTarget "ZFA:0009298" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:18803315" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000692 ; owl:annotatedTarget "perisynaptic Schwann cell" . [] oboInOwl:hasDbXref "PMID:18803315" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000692 ; owl:annotatedTarget "teloglia" . [] oboInOwl:hasDbXref "PMID:18803315" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000692 ; owl:annotatedTarget "tSC" . [] oboInOwl:hasDbXref "JB:jb", "PMID:17122314" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000693 ; owl:annotatedTarget "An interneuron that has spider-like appearance with a small round soma, a large number (7-10) of short, smooth, or slightly beaded primary dendrites that give rise to only a few secondary branches, and a branched axon that establishes a dense axonal mesh with thin shafts." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000693 ; owl:annotatedTarget "ZFA:0009299" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:18568015" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000693 ; owl:annotatedTarget "NGF cell" . [] oboInOwl:hasDbXref "PMID:3235828" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000693 ; owl:annotatedTarget "neuroglioform cell" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000694 ; owl:annotatedTarget "FBbt:00004217" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:10600995", "PMID:34047341", "PMID:36774666", "PMID:37775311", "PMID:9728912" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000695 ; owl:annotatedTarget "A type of transient, early-born glutamatergic neuron located primarily in the marginal zone (future layer I) of the developing cerebral cortex and hippocampus in vertebrates. it is characterized by a bipolar morphology with an elongated soma, a single thick dendrite oriented toward the pial surface, and a long, thin axon that extends tangentially to form horizontal plexuses across the cortical surface. It is important for the multiple developmental processes including migration, dendritogenesis and synaptogenesis. It typically undergoes programmed cell death following cortical maturation with species- and region specific patterns of survival. In mice, it is predominantly observed in the hippocampal formation, particularly in the stratum lacunosum-moleculare and outer molecular layer of the dentate gyrus (van Bruggen et al., 2023). In contrast, in humans, a second morphologically distinct subpopulation emerges mid-gestation and persists postnatally, with surviving cells observed in the cortical sulci and the hippocampus." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000695 ; owl:annotatedTarget "ZFA:0009300" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "WikipediaVersioned:Cajal–Retzius_cell&oldid=1032081753" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000695 ; owl:annotatedTarget "CR cells" . [] oboInOwl:hasDbXref "WikipediaVersioned:Cajal–Retzius_cell&oldid=1032081753" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000695 ; owl:annotatedTarget "Horizontal cells of Cajal" . [] oboInOwl:hasDbXref "PMID:10600995" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0000695 ; owl:annotatedTarget "While previously called 'pioneer neurons' of the marginal zone, Cajal-Retzius cells are differentiated from pioneer neurons (which are Reln-negative) by their Reln-immunoreactivity." . [] oboInOwl:hasDbXref "GOC:tfm", "JB:jb", "PMID:15153415" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000696 ; owl:annotatedTarget "A cell that stores and secretes pancreatic polypeptide hormone." . [] oboInOwl:hasDbXref "DOI:10.1016/j.febslet.2014.07.005", "DOI:10.1016/j.mce.2015.06.028", "DOI:10.1038/s41580-020-00317-7", "DOI:10.1210/jc.2003-030630", "DOI:10.1369/00221554155835" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000696 ; owl:annotatedTarget """PP cells, also known as pancreatic polypeptide cells (and previously called F cells or gamma cells), are enteroendocrine cells predominantly found in the islets of Langerhans in the head of the pancreas. They are one of the four main endocrine cell types present in the pancreatic islets, along with type A, B and D cells. PP cells are notable for their production of pancreatic polypeptide, an anorexigenic hormone that modulates food intake and energy homeostasis. By secreting pancreatic polypeptide, PP cells play a significant role in the management of both digestive and appetite regulation. Upon ingestion of food, there is a significant increase in the secretion of pancreatic polypeptide, which then reduces biliary secretion and helps slow down the movement of food through the digestive tract. This allows more time for digestion to take place and nutrients to be absorbed, promoting the efficient use of dietary intake. The pancreatic polypeptide further reduces appetite by interacting with the hypothalamus, the area of the brain responsible for control of hunger. Given their important role in digestion, malfunction or damage to PP cells can lead to a disturbance in the digestive process and contribute to some disease conditions. For example, an overproduction of pancreatic polypeptide can result in conditions such as pancreatic tumors and diabetes. Conversely, an under secretion might contribute to obesity due to impaired dietary control. Furthermore, PP cells may also play a role in the body's energy balance, suggesting their implication in conditions related to energy metabolism. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "PP cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000696 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000696" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000697 ; owl:annotatedTarget "FBbt:00004219" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000699 ; owl:annotatedTarget "A type of glomus or chief cell, is sensitive to hypoxia and produce catecholamines." . [] oboInOwl:hasDbXref "GOC:dhill" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000700 ; owl:annotatedTarget "A neuron that releases dopamine as a neurotransmitter." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000700 ; owl:annotatedTarget "FBbt:00005131" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000700 ; owl:annotatedTarget "ZFA:0009301" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "JB:jb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000701 ; owl:annotatedTarget "Supports paraganglial type 1 cell." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000702 ; owl:annotatedTarget "FBbt:00004221" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "JB:jb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000703 ; owl:annotatedTarget "Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000703 ; owl:annotatedTarget "ZFA:0009302" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:15376331" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000704 ; owl:annotatedTarget "A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000704 ; owl:annotatedTarget "ZFA:0009303" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000705 ; owl:annotatedTarget "FBbt:00004223" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "JB:jb", "PMID:15561411", "PMID:9550134" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000706 ; owl:annotatedTarget "A specialized ependymal cell that is part of the choroid plexus epithelium, responsible for producing cerebrospinal fluid (CSF) by selectively filtering and modifying blood plasma components before secreting it into the brain and spinal cord. This cell is characterized by a brush border on its apical surface, which enhances the secretion of CSF." . [] oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000706 ; owl:annotatedTarget "choroid plexus cell" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000706 ; owl:annotatedTarget "ZFA:0009304" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:25729351" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0000706 ; owl:annotatedTarget "A choroid plexus epithelial cell possesses non-motile 9+0 cilia. While these cilia can exhibit transient motility during development, they generally do not contribute significantly to the directional flow of cerebrospinal fluid (CSF). Instead, they are primarily involved in sensory functions." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000707 ; owl:annotatedTarget "FBbt:00004225" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000708 ; owl:annotatedTarget obo:CL_0000327 . [] oboInOwl:hasDbXref "JB:jb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000708 ; owl:annotatedTarget "Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000708 ; owl:annotatedTarget "ZFA:0009305" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000709 ; owl:annotatedTarget "FBbt:00004227" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000710 ; owl:annotatedTarget "Epithelial cells derived from neural plate and neural crest." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.copewithcytokines.org/cope.cgi?key=cumulus%20cells" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000711 ; owl:annotatedTarget "Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000712 ; owl:annotatedTarget "Any epidermal cell that is part of some stratum granulosum of epidermis." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000715 ; owl:annotatedTarget "FBbt:00001690" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:15582775" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000717 ; owl:annotatedTarget "OBSOLETE. A subset of motor neurons that innervates intrafusal muscle fibers and has small diameter axons." . [] oboInOwl:hasDbXref "PMID:34343526", "doi:10.1017/CBO9780511818202.023" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000718 ; owl:annotatedTarget "A cell of an ommatidium that secretes lens materials." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000718 ; owl:annotatedTarget "FBbt:00004193" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "doi:10.1242/jcs.s3-105.71.331" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0000718 ; owl:annotatedTarget "Not to be confused with the Semper cells of the Semper organ found in gastropods." . [] oboInOwl:hasDbXref "GO:0048103" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000723 ; owl:annotatedTarget "A stem cell that can give rise to cell types of the body other than those of the germ-line." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000723 ; owl:annotatedTarget "ZFA:0009307" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "MA:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000724 ; owl:annotatedTarget "A differentiated cell that functions as a site of nitrogen fixation under aerobic conditions." . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000725 ; owl:annotatedTarget "Any cell that is capable of some nitrogen fixation." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:085199377X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000726 ; owl:annotatedTarget "An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material." . [] oboInOwl:hasDbXref "MA:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000730 ; owl:annotatedTarget "A cell at the front of a migrating epithelial sheet." . [] oboInOwl:hasDbXref "GOC:tfm", "MA:ma", "doi:10.1038/s41385-022-00565-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000731 ; owl:annotatedTarget "A cell of a layer of transitional epithelium in the wall of the proximal urethra, bladder, ureter or renal pelvis, external to the lamina propria." . [] oboInOwl:hasDbXref "DOI:10.1002/nau.22195", "DOI:10.1038/ki.2009.73", "DOI:10.1038/ncpuro0672", "DOI:10.1038/s41579-020-0324-0", "DOI:10.1152/physrev.00041.2019" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000731 ; owl:annotatedTarget """Urothelial cells are a unique type of epithelial cell found lining the urinary tract system. They form the urothelium, a specialized, multi-layered epithelium that lines major portions of the urinary tract, including the renal pelvis, ureters, bladder, and the proximal part of the urethra. The distinct characteristic of urothelial cells is their ability to stretch and contract depending on the volume of liquid they contain - a feature that facilitates the essential role they play in maintaining the functionality and integrity of the urinary system. The primary function of urothelial cells is to provide an impermeable barrier to urine, preventing the toxic components present in the urine from seeping back into the body's bloodstream. The urothelium consists of a superficial umbrella cell layer, 1–2 layers of intermediate cells, and a basal cell layer. The umbrella layer is composed of large, mostly binucleated cells that are covered in an asymmetrical unit membrane, the uroplakin plaques. These plaques function to seal the apical membrane of the bladder from the toxic and highly variable contents of urine. The lipid bilayer structure of uroplakin plaques has an exceptionally high concentration of uroplakins that contribute to the barrier function of the urothelium. Beyond their mechanical function, urothelial cells also play a role in sensing and signaling changes in the urinary system. They express a number of sensor molecules or respond to thermal, mechanical and chemical stimuli and can release chemical mediators. This allows them to act as sensory transducers because they detect changes in the filling state of the bladder and transmit this information to the nervous system. Moreover, these versatile cells contribute to the defense mechanism against urinary tract pathogens. They respond to bacterial infections by releasing chemical messengers, cytokines and chemokines, to attract immune cells, and also can engulf pathogens via endocytosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000731 ; owl:annotatedTarget "ZFA:0009308" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "urothelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000731 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000731" . [] oboInOwl:hasDbXref "doi:10.1242/dev.00702" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000735 ; owl:annotatedTarget "A hemocyte that derives from the larval lymph gland." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000735 ; owl:annotatedTarget "FBbt:00005917" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000737 ; owl:annotatedTarget "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000737 ; owl:annotatedTarget "ZFA:0005784" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000738 ; owl:annotatedTarget obo:CL_0000988 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:978-0-323-05290-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000738 ; owl:annotatedTarget "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000738 ; owl:annotatedTarget "ZFA:0009309" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000740 ; owl:annotatedTarget "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000740 ; owl:annotatedTarget "ZFA:0009310" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "doi:10.1038/s41598-020-66092-9" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000740 ; owl:annotatedTarget "RGC" . [] oboInOwl:hasDbXref "doi:10.1038/s41598-020-66092-9" ; oboInOwl:hasSynonymType obo:OMO_0003000, obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000740 ; owl:annotatedTarget "RGCs" . [] oboInOwl:hasDbXref "PMID:16267219" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000741 ; owl:annotatedTarget "A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000741 ; owl:annotatedTarget "ZFA:0009311" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:15951842" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000742 ; owl:annotatedTarget "A round chondrocyte that first differentiates in the late embryonic growth plate of bone." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000742 ; owl:annotatedTarget "ZFA:0009312" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GO_REF:0000034", "PMID:15951842" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000743 ; owl:annotatedTarget "Chondrocyte that is terminally differentiated, produces type X collagen, is large in size, and often associated with the replacement of cartilage by bone (endochondral ossification)." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000743 ; owl:annotatedTarget "ZFA:0009313" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:15951842" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000744 ; owl:annotatedTarget "A columnar chondrocyte that differentiates in the late embryonic growth plate of bone. Columnar chondrocytes vigorously proliferate and form columns in the growth plate." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000744 ; owl:annotatedTarget "ZFA:0009314" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:0195088433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000745 ; owl:annotatedTarget "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000745 ; owl:annotatedTarget "ZFA:0009315" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "doi:10.1038/s41598-020-66092-9" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000745 ; owl:annotatedTarget "HC" . [] oboInOwl:hasDbXref "doi:10.1038/s41598-020-66092-9" ; oboInOwl:hasSynonymType obo:OMO_0003000, obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000745 ; owl:annotatedTarget "HCs" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000014 ; owl:annotatedTarget obo:CL_0000034 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000043 ; owl:annotatedTarget obo:CL_0000767 . [] oboInOwl:hasDbXref "GOC:mtg_cardiacconduct_nov11", "GOC:tfm", "ISBN:0323052908", "PMID:22426062", "PMID:4711263" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000746 ; owl:annotatedTarget "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." . [] oboInOwl:hasDbXref "DOI:10.1016/j.ccep.2010.10.012", "DOI:10.1038/nrcardio.2016.203", "https://www.ncbi.nlm.nih.gov/books/NBK572070", "https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/cardiac-muscle" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000746 ; owl:annotatedTarget """Cardiac muscle cells, also known as cardiomyocytes or cardiac myocytes, are specialized cells that form the heart tissue. These cells are elongated, branched, and contain a single centrally located nucleus. Their anatomy is composed primarily of densely packed myofibrils, which are protein structures that consist of sarcomeres - the fundamental units of muscle contraction. Cardiac muscle cells are united at their ends through specialized junctions known as intercalated discs, which allow the heart to contract in a unified, powerful and rhythmic way. Functionally, cardiac muscle cells are responsible for the heart's consistent pumping action that circulates blood throughout the body. Unlike most cells in the body, cardiac muscle cells spontaneously depolarize and generate action potentials without external stimulation. This unique trait stems from the presence of ion channels in the cells' membrane that allow a cyclic flow of ions across the membrane, which create the electrical impulses necessary for heart contraction. The spread of these electrical signals from one cardiac muscle cell to another - facilitated by the interconnected network made by the intercalated disks - results in a synchronized contraction of the heart muscle. Unlike skeletal muscle cells which can tire and need rest, cardiac muscle cells have to work ceaselessly throughout the entire lifespan, without the opportunity for rest, to ensure continuous circulation of blood. This is made possible through the high volume of mitochondria and a constant supply of oxygen from coronary circulation. In conclusion, cardiac muscle cells, through their unique structure and vital functionality, play a pivotal role in sustaining life by providing the means for blood to reach every cell in the body. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000746 ; owl:annotatedTarget "ZFA:0009316" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GO:0048739" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000746 ; owl:annotatedTarget "cardiac muscle fiber" . [] a owl:Axiom ; rdfs:label "cardiac muscle cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000746 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000746" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0721601464", "PMID:18466030", "PMID:19231594", "PMID:20837449", "http://www.cap.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000043 ; owl:annotatedTarget "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000747 ; owl:annotatedTarget "A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000747 ; owl:annotatedTarget "ZFA:0009317" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:14689473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000748 ; owl:annotatedTarget "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000748 ; owl:annotatedTarget "ZFA:0009318" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "doi:10.1038/s41598-020-66092-9" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000748 ; owl:annotatedTarget "BC" . [] oboInOwl:hasDbXref "doi:10.1038/s41598-020-66092-9" ; oboInOwl:hasSynonymType obo:OMO_0003000, obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000748 ; owl:annotatedTarget "BCs" . [] oboInOwl:hasDbXref "geo:GSE137537" ; oboInOwl:hasSynonymType obo:OMO_0003000, obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000748 ; owl:annotatedTarget "BPs" . [] oboInOwl:hasDbXref "PMID:14689473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000749 ; owl:annotatedTarget "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000749 ; owl:annotatedTarget "ZFA:0009319" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:30639325" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000047 ; owl:annotatedTarget "An undifferentiated neural cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple central nervous system neuronal and glial cell types." . [] oboInOwl:hasDbXref "PMID:14689473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000750 ; owl:annotatedTarget "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the outer half of the inner plexiform layer. These cells depolarize in response to light to dark transition." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000750 ; owl:annotatedTarget "ZFA:0009320" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:14689473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000751 ; owl:annotatedTarget "A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells but not by cone photoreceptor cells. These neurons depolarize in response to light." . [] oboInOwl:hasDbXref "PMID:38627529" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002175 ; owl:annotatedSource obo:CL_0000751 ; owl:annotatedTarget obo:NCBITaxon_32443 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000751 ; owl:annotatedTarget "ZFA:0009321" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000047 ; owl:annotatedTarget "ZFA:0009019" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:14689473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000752 ; owl:annotatedTarget "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000752 ; owl:annotatedTarget "ZFA:0009322" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:14689473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000753 ; owl:annotatedTarget "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell body of these cells is in the middle of the inner plexiform layer. The dendritic tree is stout and the axon terminates in sublamina 1. The axonal terminal is wide and has only a few varicosities." . [] oboInOwl:hasDbXref "PMID:16305818" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000047 ; owl:annotatedTarget "neuronal stem cell" . [] oboInOwl:hasDbXref "PMID:27565351" ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:CL_0000754 ; owl:annotatedTarget _:genid3167 . [] oboInOwl:hasDbXref "PMID:14689473", "PMID:27565351" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000754 ; owl:annotatedTarget "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is not well filled and the dendrites are more delicate than in type 1 cells. The axon terminal is bushier and exhibits a dense plexus of varicosities in the inner part of sublamina 1 (Ghosh et al., 2004). It can be differentiated from other retinal bipolar neurons by its expression of marker genes: Neto1, Lhx3 and Irx-6 (Shekhar, 2016)." . [] oboInOwl:hasDbXref "PMID:14689473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000755 ; owl:annotatedTarget "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is delicate and the dendritic tips appear small when compared with type 1 cells. The axon terminal is stratified and restricted to sublamina 2 of the inner plexiform layer." . [] oboInOwl:hasDbXref "PMID:14689473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000756 ; owl:annotatedTarget "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell has a diffuse axon terminal with varicosities in sublaminae 1 and 2 of the inner plexiform layer." . [] oboInOwl:hasDbXref "PMID:14689473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000757 ; owl:annotatedTarget "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is restricted to sublamina 3 of the inner plexiform layer. It is narrowly stratified and branched. The dendritic tree has many delicate branches." . [] oboInOwl:hasDbXref "PMID:14689473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000758 ; owl:annotatedTarget "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The cell has a loose, delicate axon terminal that opens in sublamina 3 of the inner plexiform layer and descends into sublamina 4." . [] oboInOwl:hasDbXref "PMID:14689473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000759 ; owl:annotatedTarget "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is narrowly stratified and are found just below a calretinin-expressing band in sublamina 4 of the inner plexiform layer." . [] oboInOwl:hasDbXref "PMID:14689473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000760 ; owl:annotatedTarget "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. This cell has the widest dendritic field and the widest axon terminal of all retinal bipolar cells. The axon terminal is delicate and stratified through sublaminae 4 and 5 of the inner plexiform layer." . [] oboInOwl:hasDbXref "PMID:14689473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000761 ; owl:annotatedTarget "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The dendritic tree is wide and the dendritic convergence indicates cone selectivity. The axon terminal is sparsely branched and terminates in sublamina 5 of the inner plexiform layer." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000762 ; owl:annotatedTarget obo:CL_0000763 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "PMID:16360205" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000762 ; owl:annotatedTarget "A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000762 ; owl:annotatedTarget "ZFA:0009323" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000763 ; owl:annotatedTarget obo:CL_0000988 . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000763 ; owl:annotatedTarget "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000763 ; owl:annotatedTarget "ZFA:0009324" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000764 ; owl:annotatedTarget "A immature or mature cell in the lineage leading to and including erythrocytes." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000764 ; owl:annotatedTarget "ZFA:0009325" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "doi:10.1016/j.stem.2012.05.016" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000014 ; owl:annotatedTarget "A stem cell that is the precursor of gametes." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000048 ; owl:annotatedTarget "A stem cell that can give rise to multiple lineages of cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000048 ; owl:annotatedTarget "ZFA:0009020" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000765 ; owl:annotatedTarget obo:CL_0000764 . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464", "PMID:18174176" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000765 ; owl:annotatedTarget "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000765 ; owl:annotatedTarget "ZFA:0005237" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget obo:CL_0002032 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000766 ; owl:annotatedTarget obo:CL_0000738 . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000766 ; owl:annotatedTarget "A cell of the monocyte, granulocyte, or mast cell lineage." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000766 ; owl:annotatedTarget "ZFA:0009326" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0878932437", "MESH:D023461" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget "ZFA:0009021" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000767 ; owl:annotatedTarget obo:CL_0000094 . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GOC:dsd", "GOC:tfm", "ISBN:0721601464", "MESH:D001491", "PMCID:PMC2626675", "PMID:11927641", "PMID:19741522", "PMID:21236338", "PMID:9933081" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000767 ; owl:annotatedTarget "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000768 ; owl:annotatedTarget obo:CL_0000767 . [] oboInOwl:hasDbXref "ISBN:0878932437" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget "CFU-GEMM" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000768 ; owl:annotatedTarget "Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking." . [] oboInOwl:hasDbXref "ISBN:0878932437" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget "CFU-S" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000014 ; owl:annotatedTarget "FBbt:00004861" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:0878932437" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget "CMP" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000769 ; owl:annotatedTarget obo:CL_0000768 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721601464", "PMID:18466030" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000769 ; owl:annotatedTarget "A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive." . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget "multipotential myeloid stem cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000770 ; owl:annotatedTarget obo:CL_0000768 . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464", "PMID:18466030", "http://www.cap.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000770 ; owl:annotatedTarget "A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget "myeloid stem cell" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget "pluripotent stem cell (bone marrow)" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000771 ; owl:annotatedTarget obo:CL_0000094 . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GOC:dsd", "GOC:tfm", "ISBN:0721601464", "PMCID:PMC2626675", "PMID:10914487", "PMID:1662676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000771 ; owl:annotatedTarget "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000772 ; owl:annotatedTarget obo:CL_0000771 . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000772 ; owl:annotatedTarget "Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000773 ; owl:annotatedTarget obo:CL_0000772 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0721601464", "PMID:19622087" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000773 ; owl:annotatedTarget "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000774 ; owl:annotatedTarget obo:CL_0000772 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0721601464", "PMID:19622087", "http://www.cap.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000774 ; owl:annotatedTarget "A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature eosinophil." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000014 ; owl:annotatedTarget "ZFA:0005956" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000775 ; owl:annotatedTarget obo:CL_0000094 . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GOC:tfm", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000775 ; owl:annotatedTarget "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000775 ; owl:annotatedTarget "ZFA:0009327" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000776 ; owl:annotatedTarget obo:CL_0000775 . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000776 ; owl:annotatedTarget "Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000776 ; owl:annotatedTarget "ZFA:0009328" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000777 ; owl:annotatedTarget obo:CL_0000864 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0702022918", "ISBN:3540536663", "PMID:1600140", "PMID:16146841" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000777 ; owl:annotatedTarget "A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000050 ; owl:annotatedTarget obo:CL_0002032 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000778 ; owl:annotatedTarget obo:CL_0000092 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "PMID:12713016", "PMID:15055519", "PMID:17380158", "PMID:9415452" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000778 ; owl:annotatedTarget "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000778 ; owl:annotatedTarget "ZFA:0009329" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000779 ; owl:annotatedTarget obo:CL_0000092 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "MESH:D055015", "PMID:16647566", "http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000050 ; owl:annotatedTarget "A progenitor cell committed to the megakaryocyte and erythroid lineages." . [] oboInOwl:hasDbXref "GOC:add", "PMID:12713016", "PMID:29379067", "PMID:38903088", "PMID:9415452" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000779 ; owl:annotatedTarget "A specialized multinuclear osteoclast, forming a syncytium through the fusion of mononuclear precursor cells, associated with the absorption and removal of bone." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000780 ; owl:annotatedTarget obo:CL_0000588 . [] oboInOwl:hasDbXref "GOC:add", "PMID:9415452" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000780 ; owl:annotatedTarget "A specialized multinuclear osteoclast associated with the absorption and removal of cementum." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000050 ; owl:annotatedTarget "ZFA:0009022" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000781 ; owl:annotatedTarget obo:CL_0000588 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000781 ; owl:annotatedTarget obo:CL_0000778 . [] oboInOwl:hasDbXref "GOC:add", "PMID:9415452" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000781 ; owl:annotatedTarget "A specialized mononuclear osteoclast associated with the absorption and removal of cementum." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000781 ; owl:annotatedTarget "ZFA:0009330" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000782 ; owl:annotatedTarget obo:CL_0000990 . [] oboInOwl:hasDbXref "GOC:add", "PMID:10449155", "PMID:17332250", "PMID:9521319" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000782 ; owl:annotatedTarget "A dendritic cell of the myeloid lineage." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000783 ; owl:annotatedTarget obo:CL_0000518 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000783 ; owl:annotatedTarget "A phagocyte formed by the fusion of mononuclear phagocytes." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000784 ; owl:annotatedTarget obo:CL_0000451 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "PMCID:PMC2118448", "PMCID:PMC538703", "PMID:15549123", "PMID:17332250", "PMID:17850486", "PMID:20304825" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000784 ; owl:annotatedTarget "A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000785 ; owl:annotatedTarget obo:CL_0001201 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000785 ; owl:annotatedTarget "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000785 ; owl:annotatedTarget "ZFA:0009331" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "CARO:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000000 ; owl:annotatedTarget "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000051 ; owl:annotatedTarget obo:CL_0002032 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000786 ; owl:annotatedTarget obo:CL_0000946 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GO_REF:0000031", "ISBN:0721601464", "ISBN:0781735149", "PMID:19447676", "PMID:20081059", "PMID:20839338", "PMID:20951740", "http://en.wikipedia.org/wiki/Plasma_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000786 ; owl:annotatedTarget "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000786 ; owl:annotatedTarget "ZFA:0009332" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "PMID:10407577", "PMID:16551251" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000051 ; owl:annotatedTarget "A oligopotent progenitor cell committed to the lymphoid lineage." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000051 ; owl:annotatedTarget "ZFA:0009023" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000787 ; owl:annotatedTarget obo:CL_0000785 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "ISBN:0781735149", "PMID:20081059", "PMID:20839338", "http://en.wikipedia.org/wiki/Memory_B_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000787 ; owl:annotatedTarget "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000787 ; owl:annotatedTarget "ZFA:0009333" ; sssom:mapping_justification . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000051 ; owl:annotatedTarget "CLP" . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000051 ; owl:annotatedTarget "ELP" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000788 ; owl:annotatedTarget obo:CL_0000785 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196", "PMID:19447676", "PMID:20081059", "PMID:20839338", "PMID:20933013", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000788 ; owl:annotatedTarget "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000788 ; owl:annotatedTarget "ZFA:0009334" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000789 ; owl:annotatedTarget obo:CL_0000084 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000052 ; owl:annotatedTarget "A stem cell from which all cells of the body can form." . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000789 ; owl:annotatedTarget "A T cell that expresses an alpha-beta T cell receptor complex." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000789 ; owl:annotatedTarget "ZFA:0009335" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000790 ; owl:annotatedTarget obo:CL_0000789 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000790 ; owl:annotatedTarget "An alpha-beta T cell that has an immature phenotype and has not completed T cell selection." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000052 ; owl:annotatedTarget "ZFA:0009024" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000791 ; owl:annotatedTarget obo:CL_0000789 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000791 ; owl:annotatedTarget "A alpha-beta T cell that has a mature phenotype." . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000055 ; owl:annotatedTarget "OBSOLETE. A precursor cell with a limited number of potential fates." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000792 ; owl:annotatedTarget obo:CL_0000624 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149", "PMID:19464985", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000792 ; owl:annotatedTarget "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000792 ; owl:annotatedTarget "Treg" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D032446", "PMID:21849021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000056 ; owl:annotatedTarget "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000793 ; owl:annotatedTarget obo:CL_0000624 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000793 ; owl:annotatedTarget "A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000015 ; owl:annotatedTarget obo:CL_0000586 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000056 ; owl:annotatedTarget "FBbt:00005083" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000056 ; owl:annotatedTarget "ZFA:0009025" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000794 ; owl:annotatedTarget obo:CL_0000625 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000794 ; owl:annotatedTarget "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." . [] oboInOwl:hasDbXref "ISBN:0517223651", "MESH:D005347", "http://en.wikipedia.org/wiki/Fibroblast" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000057 ; owl:annotatedTarget "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000795 ; owl:annotatedTarget obo:CL_0000625 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000795 ; owl:annotatedTarget "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000796 ; owl:annotatedTarget obo:CL_0000797 . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000796 ; owl:annotatedTarget "A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000057 ; owl:annotatedTarget "ZFA:0009026" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000797 ; owl:annotatedTarget obo:CL_0000791 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000797 ; owl:annotatedTarget "A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000798 ; owl:annotatedTarget obo:CL_0000084 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000798 ; owl:annotatedTarget "A T cell that expresses a gamma-delta T cell receptor complex." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000798 ; owl:annotatedTarget "ZFA:0009336" ; sssom:mapping_justification . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000798 ; owl:annotatedTarget "gd T cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000799 ; owl:annotatedTarget obo:CL_0000798 . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000799 ; owl:annotatedTarget "A gamma-delta T cell that has an immature phenotype." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000799 ; owl:annotatedTarget "ZFA:0009337" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "GO_REF:0000034", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000058 ; owl:annotatedTarget "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000800 ; owl:annotatedTarget obo:CL_0000798 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000800 ; owl:annotatedTarget "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000800 ; owl:annotatedTarget "ZFA:0009338" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000058 ; owl:annotatedTarget "ZFA:0009027" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000801 ; owl:annotatedTarget obo:CL_0000800 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000801 ; owl:annotatedTarget "A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000801 ; owl:annotatedTarget "ZFA:0009339" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000802 ; owl:annotatedTarget obo:CL_0000801 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000802 ; owl:annotatedTarget "A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000803 ; owl:annotatedTarget obo:CL_0000801 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000803 ; owl:annotatedTarget "A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative." . [] oboInOwl:hasDbXref "PMID:29462262", "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000015 ; owl:annotatedTarget "A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000805 ; owl:annotatedTarget obo:CL_0000893 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000805 ; owl:annotatedTarget "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive." . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000806 ; owl:annotatedTarget "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive." . [] oboInOwl:hasDbXref "GOC:tfm", "GO_REF:0000034", "MESH:D000565" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000059 ; owl:annotatedTarget "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000807 ; owl:annotatedTarget "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000808 ; owl:annotatedTarget "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." . [] oboInOwl:hasDbXref "GO_REF:0000034", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000060 ; owl:annotatedTarget "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000809 ; owl:annotatedTarget obo:CL_0000790 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000809 ; owl:annotatedTarget "A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM322.LZLG.752" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000809 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000060 ; owl:annotatedTarget "ZFA:0009029" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000810 ; owl:annotatedTarget obo:CL_0000790 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000810 ; owl:annotatedTarget "An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative." . [] oboInOwl:hasDbXref "DOI:10.1016/S0092-8674(00)81834-6", "DOI:10.1016/S1534-5807(02)00173-9", "DOI:10.1242/dev.202046", "https://www.ncbi.nlm.nih.gov/books/NBK553142/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000015 ; owl:annotatedTarget """Male germ cells are specialized cells that give rise to the male gametes and are therefore crucial for sexual reproduction in males. Through a complex process called spermatogenesis in the testes male germ cells undergo several stages of development, each with distinctive morphological and physiological characteristics, eventually differentiating into mature spermatozoa (sperm). Male germ cells are responsible for transferring genetic material from male to offspring as part of sexual reproduction. In the initial stage of their life cycle, they exist as spermatogonial stem cells, which multiply by mitotic division to self-renew and to produce daughter cells. The daughter cells then undergo meiotic division, a process that reduces the number of chromosomes in each cell by half, from diploid to haploid – the formation of spermatids. This is critical for maintaining genetic stability from generation to generation, as it ensures that when an egg and sperm cell unite during fertilization, the resulting offspring will have the correct number of chromosomes. The final phase of spermatogenesis is called spermiogenesis, during which spermatozoa - mature and motile sperm cells – are produced from round spermatids. The matured male germ cells or sperm cells are highly specialized, having a streamlined shape designed for efficient movement towards the female egg. A sperm cell is divided into three main parts, namely the head, midpiece, and tail. The head contains the genetic material, the midpiece contains mitochondria that provide energy, and the tail, termed as the flagellum, propels the sperm cell forward. Each of these parts play significant roles in fertilization. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000811 ; owl:annotatedTarget obo:CL_0000790 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000811 ; owl:annotatedTarget "An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000813 ; owl:annotatedTarget obo:CL_0002419 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000813 ; owl:annotatedTarget "A long-lived, antigen-experienced T cell that has acquired a memory phenotype including distinct surface markers and the ability to differentiate into an effector T cell upon antigen reexposure." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000813 ; owl:annotatedTarget "ZFA:0009342" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GO_REF:0000034", "ISBN:0781733901" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000061 ; owl:annotatedTarget "Skeletogenic cell that produces cementum (a bony substance that covers the root of a tooth), is part of the odontogenic papilla, and develops from a precementoblast cell." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000061 ; owl:annotatedTarget "ZFA:0009030" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000814 ; owl:annotatedTarget obo:CL_0000791 . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000814 ; owl:annotatedTarget "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000815 ; owl:annotatedTarget obo:CL_0002419 . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000815 ; owl:annotatedTarget "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "PMID:20081059", "PMID:20839338" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000816 ; owl:annotatedTarget "An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000816 ; owl:annotatedTarget "ZFA:0009343" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:781735149" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000816 ; owl:annotatedTarget "newly formed B cell" . [] oboInOwl:hasDbXref "GO_REF:0000034", "MESH:D010006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000062 ; owl:annotatedTarget "Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000817 ; owl:annotatedTarget obo:CL_0001201 . [] oboInOwl:hasDbXref "GOC:rhs", "GOC:tfm", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000817 ; owl:annotatedTarget "A precursor B cell is a B cell with the phenotype CD10-positive." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000817 ; owl:annotatedTarget "ZFA:0009344" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000062 ; owl:annotatedTarget "ZFA:0009031" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FB:ma", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000063 ; owl:annotatedTarget "OBSOLETE: A classification of cells by their microscopic appearance." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000818 ; owl:annotatedTarget obo:CL_0001201 . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000031", "ISBN:0781735149", "PMID:12810111", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000818 ; owl:annotatedTarget "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000818 ; owl:annotatedTarget "ZFA:0009345" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000818 ; owl:annotatedTarget "transitional B cell" . [] a owl:Axiom ; rdfs:label "male germ cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000015 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000015" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000819 ; owl:annotatedTarget obo:CL_0000785 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GO_REF:0000031", "PMID:11861604", "PMID:20933013", "PMID:21220451", "http://en.wikipedia.org/wiki/B-1_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000819 ; owl:annotatedTarget "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000820 ; owl:annotatedTarget obo:CL_0000819 . [] oboInOwl:hasDbXref "GOC:add", "PMID:11861604" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000820 ; owl:annotatedTarget "A B-1 B cell that has the phenotype CD5-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000821 ; owl:annotatedTarget obo:CL_0000819 . [] oboInOwl:hasDbXref "GOC:add", "PMID:11861604" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000821 ; owl:annotatedTarget "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000822 ; owl:annotatedTarget obo:CL_0000785 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0781735149", "PMID:11861604", "PMID:20933013" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000822 ; owl:annotatedTarget "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000031", "ISBN:0781735149", "PMID:12457618" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000823 ; owl:annotatedTarget "A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000064 ; owl:annotatedTarget "A cell that has a filiform extrusion of the cell surface." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000823 ; owl:annotatedTarget "ZFA:0009346" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:12457618" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000823 ; owl:annotatedTarget "p-NK" . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000031", "ISBN:0781735149", "PMID:14685782" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000824 ; owl:annotatedTarget "A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules." . [] oboInOwl:hasDbXref "PMID:14685782" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000824 ; owl:annotatedTarget "LAK cell" . [] oboInOwl:hasDbXref "PMID:14685782" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000824 ; owl:annotatedTarget "lymphokine activated killer cell" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000824 ; owl:annotatedTarget "ZFA:0009347" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000064 ; owl:annotatedTarget "ZFA:0009032" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000825 ; owl:annotatedTarget obo:CL_0000838 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:11532393", "PMID:12457618", "PMID:15032583", "PMID:15766674" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000825 ; owl:annotatedTarget "A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000825 ; owl:annotatedTarget "ZFA:0009348" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:12457618", "PMID:15032583", "PMID:15766674" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000825 ; owl:annotatedTarget "NKP" . [] oboInOwl:hasDbXref "PMID:11532393" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000825 ; owl:annotatedTarget "null cell" . [] oboInOwl:hasDbXref "PMID:11532393" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000825 ; owl:annotatedTarget "preNK cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000826 ; owl:annotatedTarget obo:CL_0000838 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "ISBN:0781735149", "PMID:12633665", "PMID:16551251", "PMID:18432934" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000826 ; owl:annotatedTarget "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs." . [] oboInOwl:hasDbXref "PMID:17582343" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000826 ; owl:annotatedTarget "pre-pro B cell" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000826 ; owl:annotatedTarget "ZFA:0009349" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:11244048" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000826 ; owl:annotatedTarget "pre-B cell (Philadelphia nomenclature)" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000827 ; owl:annotatedTarget obo:CL_0000838 . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000827 ; owl:annotatedTarget "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000827 ; owl:annotatedTarget "ZFA:0009350" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "doi:10.1016/j.stem.2012.05.016" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000016 ; owl:annotatedTarget "A stem cell that is the precursor of male gametes." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000828 ; owl:annotatedTarget obo:CL_0000839 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "PMID:7758949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000828 ; owl:annotatedTarget "A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000828 ; owl:annotatedTarget "ZFA:0009351" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000829 ; owl:annotatedTarget obo:CL_0000835 . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000829 ; owl:annotatedTarget "A myeloblast committed to the basophil lineage." . [] oboInOwl:hasDbXref "GOC:tfm", "JB:jb", "PMID:34335193", "PMID:37008045", "PMID:9550134", "doi:/10.3389/fncel.2021.703951", "https://www.britannica.com/science/ependymal-cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000065 ; owl:annotatedTarget "A neuroepithelial glial cell, derived from a radial glial cell originating from the neuroectoderm, lines the ventricles of the brain and the central canal of the spinal cord. This cell is characterized by the presence of cilia on its apical surface, which can be motile or non-motile." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000830 ; owl:annotatedTarget obo:CL_0000836 . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000830 ; owl:annotatedTarget "A promyelocyte committed to the basophil lineage." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000065 ; owl:annotatedTarget "ZFA:0009033" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "doi:10.53347/rID-51713" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_0000065 ; owl:annotatedTarget "ependymocyte" . [] oboInOwl:hasDbXref "FB:ma", "GOC:tfm", "MESH:D004847" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000066 ; owl:annotatedTarget "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000066 ; owl:annotatedTarget "FBbt:00000124" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000066 ; owl:annotatedTarget "ZFA:0009034" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000016 ; owl:annotatedTarget "FBbt:00004929" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000831 ; owl:annotatedTarget obo:CL_0000839 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "PMCID:PMC1183570", "PMCID:PMC1312421", "PMID:8629001", "PMID:9354811", "http://www.copewithcytokines.de" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000831 ; owl:annotatedTarget "A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000832 ; owl:annotatedTarget obo:CL_0000835 . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000832 ; owl:annotatedTarget "A myeloblast committed to the eosinophil lineage." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000833 ; owl:annotatedTarget obo:CL_0000836 . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000833 ; owl:annotatedTarget "A promyelocyte committed to the eosinophil lineage." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000834 ; owl:annotatedTarget obo:CL_0002191 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000834 ; owl:annotatedTarget "A progenitor cell of the neutrophil lineage." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000834 ; owl:annotatedTarget "ZFA:0009352" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000067 ; owl:annotatedTarget "An epithelial cell that has a cilia." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000067 ; owl:annotatedTarget "ZFA:0009035" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000835 ; owl:annotatedTarget obo:CL_0002191 . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464", "http://en.wikipedia.org/wiki/Myeloblast", "http://www.cap.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000835 ; owl:annotatedTarget "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000835 ; owl:annotatedTarget "ZFA:0009353" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GOC:tfm", "ISBN:0721601464", "http://www.cap.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000836 ; owl:annotatedTarget "A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000068 ; owl:annotatedTarget "An epithelial cell that is part of a duct." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000068 ; owl:annotatedTarget "ZFA:0009372" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000837 ; owl:annotatedTarget "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000837 ; owl:annotatedTarget "ZFA:0009354" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000838 ; owl:annotatedTarget obo:CL_0002031 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000838 ; owl:annotatedTarget "A progenitor cell restricted to the lymphoid lineage." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000838 ; owl:annotatedTarget "ZFA:0009355" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000839 ; owl:annotatedTarget obo:CL_0002031 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000839 ; owl:annotatedTarget "A progenitor cell restricted to the myeloid lineage." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000839 ; owl:annotatedTarget "ZFA:0009356" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000840 ; owl:annotatedTarget obo:CL_0000990 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "PMID:9521319" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000840 ; owl:annotatedTarget "An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000071 ; owl:annotatedTarget "An endothelial cell that lines the vasculature." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000841 ; owl:annotatedTarget obo:CL_0000990 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "PMID:9521319" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000841 ; owl:annotatedTarget "A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000841 ; owl:annotatedTarget "mature dendritic cell" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000071 ; owl:annotatedTarget "ZFA:0009036" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000842 ; owl:annotatedTarget obo:CL_0000738 . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000842 ; owl:annotatedTarget "A leukocyte with a single non-segmented nucleus in the mature form." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000842 ; owl:annotatedTarget "ZFA:0009357" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:0471245208", "PMID:12662305" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000074 ; owl:annotatedTarget "Obsolete. Use PO:0000066 from Plant Ontology instead. A cell that constitutes the mesophyll of a hydathode and is located between the xylem endings and the epidermis. Proposed to be involved in the retrieval of solutes from the xylem sap." . [] oboInOwl:hasDbXref "GO:0002065", "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000075 ; owl:annotatedTarget "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "ISBN:0781735149", "PMCID:PMC2193793", "PMID:20933013", "http://en.wikipedia.org/wiki/Follicular_B_Cells" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000843 ; owl:annotatedTarget "A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000075 ; owl:annotatedTarget "ZFA:0009038" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000844 ; owl:annotatedTarget obo:CL_0000785 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0781735149", "PMID:19447676", "PMID:20933013" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000844 ; owl:annotatedTarget "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000076 ; owl:annotatedTarget "ZFA:0009039" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544", "PMID:26106328" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000077 ; owl:annotatedTarget "A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000845 ; owl:annotatedTarget obo:CL_0000785 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "ISBN:0781735149", "PMID:10933592", "PMID:20933013", "http://en.wikipedia.org/wiki/Marginal-zone_B_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000845 ; owl:annotatedTarget "A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high." . [] oboInOwl:hasDbXref "PMID:11223304" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000846 ; owl:annotatedTarget "An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings." . [] oboInOwl:hasDbXref "PMID:16841163" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000847 ; owl:annotatedTarget "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000077 ; owl:annotatedTarget "ZFA:0009040" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000847 ; owl:annotatedTarget "ZFA:0009358" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:16841163" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000848 ; owl:annotatedTarget "An olfactory receptor cell in which the apical ending of the dendrite is a knob that bears numerous microvilli." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000848 ; owl:annotatedTarget "ZFA:0009359" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:16841163" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000849 ; owl:annotatedTarget "An olfactory receptor cell with short cilia growing in an invagination bordered by microvilli." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000849 ; owl:annotatedTarget "ZFA:0009360" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:26106328" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0000077 ; owl:annotatedTarget "Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport." . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000850 ; owl:annotatedTarget "A neuron that releases serotonin as a neurotransmitter." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000850 ; owl:annotatedTarget "FBbt:00005133" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000850 ; owl:annotatedTarget "ZFA:0009361" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:0125296509" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000851 ; owl:annotatedTarget "Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000851 ; owl:annotatedTarget "ZFA:0009362" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "ISBN:0125296509" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000852 ; owl:annotatedTarget "Neuromast support cell is a non-sensory cell of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; neuromast support cells are surrounded by neuromast mantle cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000852 ; owl:annotatedTarget "ZFA:0009363" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000853 ; owl:annotatedTarget "Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000853 ; owl:annotatedTarget "ZFA:0009364" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000854 ; owl:annotatedTarget "Interneuromast cell is a neuroectodermal cell deposited by the migrating lateral line primordium between the neuromasts. Interneuromast cells proliferate and migrate to form additional neuromasts." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000854 ; owl:annotatedTarget "ZFA:0009365" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000855 ; owl:annotatedTarget "Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000855 ; owl:annotatedTarget "ZFA:0009366" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000856 ; owl:annotatedTarget "Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000856 ; owl:annotatedTarget "ZFA:0009367" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000857 ; owl:annotatedTarget "A skeletal muscle myoblast that differentiates into slow muscle fibers." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000857 ; owl:annotatedTarget "ZFA:0009368" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000858 ; owl:annotatedTarget "A skeletal muscle myoblast that differentiates into fast muscle fibers." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000858 ; owl:annotatedTarget "ZFA:0009369" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FBC:Autogenerated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000078 ; owl:annotatedTarget "Any squamous epithelial cell that is part of some periderm." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000860 ; owl:annotatedTarget obo:CL_0000576 . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000031", "PMID:16322748", "PMID:18303997", "PMID:20628149", "PMID:20870168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000860 ; owl:annotatedTarget "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." . [] oboInOwl:hasDbXref "DOI:10.1038/nri.2017.28", "DOI:10.1111/sji.12883", "DOI:10.1182/blood-2009-07-235028", "DOI:10.3389/fimmu.2015.00423/full", "DOI:10.3389/fimmu.2019.02035" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000860 ; owl:annotatedTarget """Classical monocytes are a subtype of monocytes that are characterized by high CD14 but no CD16 expression. Emerging from the bone marrow and entering the bloodstream, these cells play central roles in immune responses and regulation of inflammation. CD14-positive CD16-negative monocytes form the majority of circulating monocytes in the body, typically contributing to around 80-90% of the total monocyte pool. The primary function of the classical monocytes is to serve in the frontline of host defense against infections. They are primed to migrate to sites of infection, and they express pattern recognition receptors that help them identify and phagocytose pathogens, leading to their destruction. Classical monocytes also contribute to inflammation by producing several pro-inflammatory cytokines including interleukins and tumor necrosis factors. In response to specific signals from tissues under pathological conditions, such as infection or injury, classical monocytes can leave the bloodstream and migrate towards the affected sites. Following their arrival, these cells differentiate into diverse cell types including macrophages and dendritic cells to combat specific pathogens or injury. Dysregulated monocyte activity can lead to the development of many human diseases including inflammation, infection, tissue injury, and various autoimmune diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "classical monocyte on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000860 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000860" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000078 ; owl:annotatedTarget "ZFA:0009041" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000861 ; owl:annotatedTarget obo:CL_0000235 . [] oboInOwl:hasDbXref "GOC:add", "GOC:ana", "GOC:tfm", "GO_REF:0000031", "PMID:15771589" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000861 ; owl:annotatedTarget "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000862 ; owl:annotatedTarget obo:CL_0000861 . [] oboInOwl:hasDbXref "Wikipedia:Epithelium", "doi:/10.1016/B978-0-12-410424-2.00003-2", "https://www.biologyonline.com/dictionary/stratified-epithelium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000079 ; owl:annotatedTarget "An epithelial cell, organized into multiple layers, with only the basal layer being in contact with the basement membrane." . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "PMID:20402419" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000862 ; owl:annotatedTarget "A macrophage that suppresses immune responses." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000079 ; owl:annotatedTarget "ZFA:0009042" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000863 ; owl:annotatedTarget obo:CL_0000861 . [] oboInOwl:hasDbXref "GOC:ana", "GO_REF:0000031", "PMID:19132917" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000863 ; owl:annotatedTarget "An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity." . [] oboInOwl:hasDbXref "DOI:10.1038/s41392-023-01452-1", "DOI:10.1186/s12935-021-02089-2", "DOI:10.3389/fimmu.2015.00263", "DOI:10.3389/fimmu.2020.583084" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000863 ; owl:annotatedTarget """Inflammatory macrophages, also sometimes referred to as M1 or classically activated macrophages, play an important role in the inflammatory response. The M1/M2 classification is based upon macrophage polarization rather than macrophage location and refers to macrophage activation towards either a more inflammatory or more resolving phenotype, respectively, although the functional diversity of macrophages is more nuanced than such a dichotomy suggests. Inflammatory macrophages are derived from monocytes recruited to a site of infection or injury. M1 macrophages are classically activated, typically by IFN-γ or lipopolysaccharide (LPS). Upon sensing signs of inflammation, they quickly respond by increasing their pro-inflammatory activity. They achieve this by producing a range of signaling molecules, such as nitric oxide, reactive oxygen species, and numerous cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1, -6 and -12. The release of these potent molecules helps to recruit other immune cells to the site, killing off pathogenic organisms and facilitation inflammation. At the same time, M1 macrophages can also present antigens to T cells, thereby helping to induce an adaptive immune response. Over time, these macrophages may transition in phenotype and function to help resolve the inflammation and promote tissue repair. Despite the beneficial role of inflammatory macrophages in dealing with pathogens, chronic activation of these cells can lead to harmful effects. Over time, continuous production of pro-inflammatory molecules can cause damage to tissues and organs. This is seen in certain chronic inflammatory diseases, such as atherosclerosis, diabetes, obesity, asthma, and various autoimmune disorders. In such situations, the normally protective function of inflammatory macrophages is not properly controlled, which can contribute to disease pathology. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "PMID:28923980" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000863 ; owl:annotatedTarget "M1 macrophage" . [] a owl:Axiom ; rdfs:label "inflammatory macrophage on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000863 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000863" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000864 ; owl:annotatedTarget obo:CL_0000235 . [] oboInOwl:hasDbXref "GOC:ana", "GO_REF:0000031", "PMID:19770654" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000864 ; owl:annotatedTarget "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." . [] oboInOwl:hasDbXref "GOC:ana", "GOC:tfm", "GO_REF:0000031", "https://orcid.org/0000-0002-2825-0621" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000865 ; owl:annotatedTarget "A gut-associated lymphoid tissue macrophage found in lamina propria of the gut." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000866 ; owl:annotatedTarget obo:CL_0000864 . [] oboInOwl:hasDbXref "GOC:ana", "GOC:tfm", "GO_REF:0000031", "PMID:9048205" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000866 ; owl:annotatedTarget "A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes." . [] oboInOwl:hasDbXref "GOC:ana", "GOC:tfm", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000867 ; owl:annotatedTarget "A tissue-resident macrophage found in a secondary lymphoid organ." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000000 ; owl:annotatedTarget "FBbt:00007002" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000868 ; owl:annotatedTarget obo:CL_0000867 . [] oboInOwl:hasDbXref "GOC:ana", "GOC:tfm", "GO_REF:0000031", "PMID:11971865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000868 ; owl:annotatedTarget "A secondary lymphoid organ macrophage found in a lymph node. This cell is CD169-high." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000080 ; owl:annotatedTarget "A cell which moves among different tissues of the body, via blood, lymph, or other medium." . [] oboInOwl:hasDbXref "GOC:ana", "GO_REF:0000031", "PMID:16048540" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000869 ; owl:annotatedTarget "A gut-associated lymphoid tissue macrophage found in tonsils." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000080 ; owl:annotatedTarget "ZFA:0009043" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000870 ; owl:annotatedTarget obo:CL_0000885 . [] oboInOwl:hasDbXref "GOC:ana", "GOC:tfm", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000870 ; owl:annotatedTarget "A gut-associated lymphoid tissue macrophage found in the Peyer's patches." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000871 ; owl:annotatedTarget obo:CL_0000867 . [] oboInOwl:hasDbXref "GO_REF:0000031", "PMID:15771589", "PMID:16322748" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000871 ; owl:annotatedTarget "A secondary lymphoid organ macrophage found in the spleen." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000872 ; owl:annotatedTarget obo:CL_0000871 . [] oboInOwl:hasDbXref "GOC:ana", "GO_REF:0000031", "PMID:16861066" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000872 ; owl:annotatedTarget "A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM355.ZFMS.256" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000872 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-red-pulp/v1.2/assets/2d-ftu-spleen-red-pulp.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000873 ; owl:annotatedTarget obo:CL_0000871 . [] oboInOwl:hasDbXref "GOC:ana", "GO_REF:0000031", "PMID:20018690" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000873 ; owl:annotatedTarget "A splenic macrophage found in the areas surrounding the white pulp of the spleen, adjacent to the marginal sinus. Markers include F4/80-negative, Dectin2-low, sialoadhesin-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000081 ; owl:annotatedTarget obo:CL_0000988 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000081 ; owl:annotatedTarget "A cell found predominately in the blood." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000081 ; owl:annotatedTarget "ZFA:0009044" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000874 ; owl:annotatedTarget obo:CL_0000871 . [] oboInOwl:hasDbXref "GOC:ana", "GO_REF:0000031", "PMID:19644016" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000874 ; owl:annotatedTarget "A splenic macrophage found in the red-pulp of the spleen, and involved in immune responses to blood-borne pathogens and in the clearance of senescent erythrocytes. Markers include F4/80-positive, CD68-positive, MR-positive, Dectin2-positive, macrosialin-positive, and sialoadhesin-low." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM355.ZFMS.256" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000874 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-red-pulp/v1.2/assets/2d-ftu-spleen-red-pulp.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000875 ; owl:annotatedTarget obo:CL_0000576 . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000031", "PMID:16322748", "PMID:18303997", "PMID:20628149", "PMID:20870168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000875 ; owl:annotatedTarget "A type of monocyte characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, and decrease size relative to classical monocytes, but increased co-stimulatory activity. May also play a role in tissue repair." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000876 ; owl:annotatedTarget obo:CL_0000871 . [] oboInOwl:hasDbXref "GOC:ana", "GO_REF:0000031", "PMID:11207597" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000876 ; owl:annotatedTarget "A splenic macrophage found in the white pulp of the spleen. Markers include F4/80-negative, CD68-positive, and macrosialin-positive." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM559.FNBB.6273" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000876 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-white-pulp/v1.2/assets/2d-ftu-spleen-white-pulp.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000877 ; owl:annotatedTarget obo:CL_0000876 . [] oboInOwl:hasDbXref "GOC:ana", "GOC:tfm", "GO_REF:0000031", "PMID:19631584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000877 ; owl:annotatedTarget "A splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centers. A marker for a cell of this type is Mertk-positive." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000082 ; owl:annotatedTarget "An epithelial cell of the lung." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM355.ZFMS.256" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000877 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-red-pulp/v1.2/assets/2d-ftu-spleen-red-pulp.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000878 ; owl:annotatedTarget obo:CL_0000864 . [] oboInOwl:hasDbXref "GO_REF:0000031", "PMID:16322748" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000878 ; owl:annotatedTarget "A tissue-resident macrophage found in the central nervous system." . [] oboInOwl:hasDbXref "DOI:10.1007/s00281-013-0382-8", "DOI:10.1016/j.immuni.2022.10.005", "DOI:10.1016/j.tins.2021.07.002", "DOI:10.1038/s41583-019-0201-x" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000878 ; owl:annotatedTarget """Central Nervous System (CNS) macrophages represent an integral part of the brain's innate immune system. These immune cells play crucial roles in maintenance and regulation, homeostasis, and disease response, thereby helping in the overall cognitive functioning of an organism. There are different macrophage populations in the CNS, often classified into microglial cells, which reside in the parenchyma, and non-parenchymal macrophages at the interface between the brain and the periphery, including the perivascular spaces, the choroid plexus, and the meninges. CNS macrophages are derived from erythromyeloid progenitors in the yolk sac. CNS macrophages have distinct morphologies: Meningeal and perivascular macrophages have a more elongated shape than microglia, which are characterized by a small cell body with fine processes; in contrast, choroid plexus macrophages typically have a stellate shape. Microglia are the most abundant abundant mononuclear phagocytes and have been shown to play a number of physiological roles, including proinflammatory and anti-inflammatory functions, synaptic pruning and remodeling, and apoptotic cell removal through phagocytosis. Non-parenchymal CAMs primarily support the barrier function against external antigens. Meningeal macrophages have been shown to respond to peripheral microbial challenges and to protect the brain against fatal viral infection. CNS macrophages are also involved in the initiation and progression of many neurological diseases, such as Alzheimer's disease and Parkinson's disease as well as multiple sclerosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "central nervous system macrophage on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000878 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000878" . [] oboInOwl:hasDbXref "GOC:ana", "GO_REF:0000031", "PMID:11591794", "PMID:24078900", "PMID:37232741" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000879 ; owl:annotatedTarget "A border associated macrophage that is part of a meninx. This macrophage type is elongated and amoeboid spindle-shaped with limited mobility. This macrophage is highly phagocytic, expresses scavenger receptors, has dynamic protrusions and extends its processes during inflammation." . [] oboInOwl:hasDbXref "PMID:33556248" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000879 ; owl:annotatedTarget "subdural leptomeningeal macrophage" . [] oboInOwl:hasDbXref "PMID:28323268" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000879 ; owl:annotatedTarget "subdural meningeal macrophage" . [] oboInOwl:hasDbXref "PMID:33556248" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000879 ; owl:annotatedTarget "MM" . [] oboInOwl:hasDbXref "PMID:38347231" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000879 ; owl:annotatedTarget "MnMΦ" . [] oboInOwl:hasDbXref "PMID:37232741" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000879 ; owl:annotatedTarget "sdΜΦ" . [] oboInOwl:hasDbXref "GOC:ana", "GO_REF:0000031", "PMID:37232741", "PMID:9550136" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000880 ; owl:annotatedTarget "A border associated macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This central nervous system macrophage has a star-like shaped body and expresses scavenger receptors." . [] oboInOwl:hasDbXref "PMID:37232741" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000880 ; owl:annotatedTarget "cpMΦ" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000881 ; owl:annotatedTarget obo:CL_4042003 . [] oboInOwl:hasDbXref "GOC:tfm", "GO_REF:0000031", "PMID:16507898", "PMID:37232741" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000881 ; owl:annotatedTarget "A border associated macrophage that is adjacent to a small blood vessel of a brain. A perivascular macrophage expresses the markers CD14, CD16 and CD163. In homeostatic conditions, this central nervous system macrophage has a non-motile cell body with extending and retracting projections through the blood vessel wall." . [] oboInOwl:hasDbXref "PMID:37232741" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000881 ; owl:annotatedTarget "pvMΦ" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000882 ; owl:annotatedTarget obo:CL_0000866 . [] oboInOwl:hasDbXref "GOC:ana", "GO_REF:0000031", "PMID:9048205" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000882 ; owl:annotatedTarget "A thymic macrophage found in the thymic medulla." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM322.LZLG.752" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000882 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000083 ; owl:annotatedTarget "An epithelial cell of the pancreas." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000883 ; owl:annotatedTarget obo:CL_0000866 . [] oboInOwl:hasDbXref "GOC:ana", "GOC:tfm", "GO_REF:0000031", "PMID:9048205" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000883 ; owl:annotatedTarget "A thymic macrophage found in the thymic cortex." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM322.LZLG.752" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000883 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000083 ; owl:annotatedTarget "ZFA:0009045" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000884 ; owl:annotatedTarget obo:CL_0000867 . [] oboInOwl:hasDbXref "GOC:ana", "GOC:tfm", "GO_REF:0000031", "PMID:19906191" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000884 ; owl:annotatedTarget "A tissue-resident macrophage found in the mucosa associated lymphoid tissue." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000885 ; owl:annotatedTarget obo:CL_0000884 . [] oboInOwl:hasDbXref "GOC:ana", "GO_REF:0000031", "PMID:19906191" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000885 ; owl:annotatedTarget "A mucosa-associated lymphoid tissue macrophage found in the mucosa-associated lymphoid tissues of the gut." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000886 ; owl:annotatedTarget obo:CL_0000884 . [] oboInOwl:hasDbXref "GOC:ana", "GO_REF:0000031", "PMID:16048540" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000886 ; owl:annotatedTarget "A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000887 ; owl:annotatedTarget obo:CL_0000868 . [] oboInOwl:hasDbXref "GOC:tfm", "GO_REF:0000031", "PMID:14668803", "PMID:17934446", "PMID:20228797" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000887 ; owl:annotatedTarget "A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens. This macrophage is capable of activating invaraint NKT cells and is CD169-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000888 ; owl:annotatedTarget obo:CL_0000868 . [] oboInOwl:hasDbXref "GOC:ana", "GOC:tfm", "GO_REF:0000031", "PMID:19631584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000888 ; owl:annotatedTarget "A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers." . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D013090" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000017 ; owl:annotatedTarget "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000889 ; owl:annotatedTarget obo:CL_0000766 . [] oboInOwl:hasDbXref "GOC:add", "GOC:ana", "GO_REF:0000031", "PMID:16168663", "PMID:17016554", "PMID:17016559" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000889 ; owl:annotatedTarget "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000084 ; owl:annotatedTarget obo:CL_0000542 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000890 ; owl:annotatedTarget obo:CL_0000861 . [] oboInOwl:hasDbXref "GOC:ana", "GOC:tfm", "GO_REF:0000031", "PMID:20510870" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000890 ; owl:annotatedTarget "An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling." . [] oboInOwl:hasDbXref "DOI:10.1038/s41392-023-01452-1", "DOI:10.1186/s12935-021-02089-2", "DOI:10.3389/fimmu.2015.00263", "DOI:10.3389/fimmu.2020.583084" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000890 ; owl:annotatedTarget """Alternatively activated macrophages, also referred to as M2 macrophages, are immune cells originating from monocytes. The M1/M2 classification is based upon macrophage polarization rather than macrophage location and refers to macrophage activation towards either a more inflammatory or more resolving phenotype, respectively, although the functional diversity of macrophages is more nuanced than such a dichotomy suggests. M2 macrophages cells are differentiated from their precursors generally in response to Th2 cytokines, such as interleukin-4 (IL-4), interleukin-10 (IL-10), and interleukin-13 (IL-13). Tissue-resident macrophages are also sometimes said to have an “M2-like” phenotype. M2 macrophages play key roles in immunoregulation and disease resolution. Functionally, alternatively activated macrophages are essential in wound healing and tissue repair and remodeling, largely due to their potent anti-inflammatory actions and their ability to promote angiogenesis. They achieve these functions by the production of specific growth factors and signaling proteins including Arg1, Ym1/2, Fizz1, and TGF-β. Additionally, they provide defense against specific categories of pathogens, particularly parasites, through specific communication with Th2 cells. However, dysfunction of M2 macrophages can be harmful. Alternatively activated macrophages have been associated with several pathological conditions such as asthma, fibrosis, and tumor progression. This is due to their capacity to inhibit inflammatory responses, promote unneeded wound healing processes, and support tumour growth and spreading. Furthermore, complex roles have been observed in metabolic disorders, cardiovascular diseases, and neurodegenerative diseases, showing the diverse functional spectrum of these cells. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "PMID:28923980" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000890 ; owl:annotatedTarget "M2 macrophage" . [] a owl:Axiom ; rdfs:label "alternatively activated macrophage on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000890 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000890" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000891 ; owl:annotatedTarget "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000084 ; owl:annotatedTarget "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." . [] oboInOwl:hasDbXref "GOC:add", "PMID:30664015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000892 ; owl:annotatedTarget "A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000893 ; owl:annotatedTarget obo:CL_0002420 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "PMID:12415312" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000893 ; owl:annotatedTarget "An immature T cell located in the thymus." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000084 ; owl:annotatedTarget "ZFA:0009046" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000894 ; owl:annotatedTarget obo:CL_0000827 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000894 ; owl:annotatedTarget "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000895 ; owl:annotatedTarget obo:CL_0000624 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "PMID:19100699", "PMID:22343568", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000895 ; owl:annotatedTarget "An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000895 ; owl:annotatedTarget "naive CD4+ T cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000895 ; owl:annotatedTarget "Th0" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000896 ; owl:annotatedTarget obo:CL_0000624 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000896 ; owl:annotatedTarget "A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000897 ; owl:annotatedTarget "A CD4-positive, alpha-beta T cell that has differentiated into a memory T cell." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000017 ; owl:annotatedTarget "FBbt:00004936" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000898 ; owl:annotatedTarget obo:CL_0002419 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19100699" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000898 ; owl:annotatedTarget "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000899 ; owl:annotatedTarget obo:CL_0000492 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:20303875", "PMID:20969597", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000899 ; owl:annotatedTarget "CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000899 ; owl:annotatedTarget "Th17 CD4+ T cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000900 ; owl:annotatedTarget obo:CL_0000625 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "PMID:22343568", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000900 ; owl:annotatedTarget "A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000900 ; owl:annotatedTarget "naive CD8+ T cell" . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:16903904" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000901 ; owl:annotatedTarget "CD4-positive alpha-beta T cell with regulatory function that produces IL-10." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000902 ; owl:annotatedTarget obo:CL_0000792 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19464985" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000902 ; owl:annotatedTarget "CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000903 ; owl:annotatedTarget obo:CL_0000792 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19464985" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000903 ; owl:annotatedTarget "CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000017 ; owl:annotatedTarget "ZFA:0009005" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000904 ; owl:annotatedTarget obo:CL_0001204 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000904 ; owl:annotatedTarget "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000904 ; owl:annotatedTarget "central memory CD4+ T cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000905 ; owl:annotatedTarget obo:CL_0001204 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000905 ; owl:annotatedTarget "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000905 ; owl:annotatedTarget "effector memory CD4+ T cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000906 ; owl:annotatedTarget obo:CL_0000625 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000906 ; owl:annotatedTarget "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000091 ; owl:annotatedTarget obo:CL_0000864 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000907 ; owl:annotatedTarget obo:CL_0001203 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:20146720", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000907 ; owl:annotatedTarget "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000907 ; owl:annotatedTarget "central memory CD8+ T cell" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0517223651", "MESH:D007728", "PMID:15771589", "PMID:17105582" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000091 ; owl:annotatedTarget "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system." . [] oboInOwl:hasDbXref "DOI:10.1002/cphy.c120026", "DOI:10.1007/978-1-4939-1311-4_10", "DOI:10.1016/j.immuni.2022.08.002", "DOI:10.1038/nri.2017.11", "DOI:10.1111/j.1478-3231.2006.01342.x" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000091 ; owl:annotatedTarget """Kupffer cells are tissue-resident macrophages located in the liver. They are an integral part of the mononuclear phagocyte system and are responsible for the phagocytosis of dead or dying cells, microbes, and other foreign substances. Kupffer cells account for approximately 80-90% of tissue-resident macrophages in the body. They are found within the lumen of liver sinusoids and interface with microbial populations and products. The primary role of Kupffer cells is to maintain homeostasis in the liver. They continuously filter and cleanse the blood that flows through the liver, removing pathogens, endotoxins, particulate matter, aged and dysfunctional red blood cells, and miscellaneous waste products. These cells also play an important role in maintaining iron homeostasis. During the process of phagocytosis, Kupffer cells recycle iron from degraded red blood cells, which is then utilized in the formation of new erythrocytes. Kupffer cells also play key roles in various immune responses and inflammatory processes. They secrete various types of cytokines and chemokines, which contribute to the activation and mobilization of other immune cells. They can also produce reactive oxygen species and nitric oxide, which have microbicidal actions. Although their activity is essential for host defense, excessive or prolonged activation of Kupffer cells may contribute to hepatic injury, inflammation, and fibrosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "Kupffer cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000091 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000091" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000908 ; owl:annotatedTarget obo:CL_0000625 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:20146720" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000908 ; owl:annotatedTarget "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM889.CJPK.447" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000091 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" . [] oboInOwl:hasDbXref "GOC:add", "PMID:20146720" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000909 ; owl:annotatedTarget "A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000910 ; owl:annotatedTarget obo:CL_0000911 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:18395547" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000910 ; owl:annotatedTarget "A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000911 ; owl:annotatedTarget obo:CL_0002419 . [] oboInOwl:hasDbXref "GOC:PAM-ADD", "GOC:tfm", "ISBN:0877799148", "PMID:18395547" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000911 ; owl:annotatedTarget "A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000912 ; owl:annotatedTarget obo:CL_0000911 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:18395547" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000912 ; owl:annotatedTarget "A effector T cell that provides help in the form of secreted cytokines to other immune cells." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000913 ; owl:annotatedTarget obo:CL_0001203 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:20146720", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000913 ; owl:annotatedTarget "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000913 ; owl:annotatedTarget "effector memory CD8+ T cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000914 ; owl:annotatedTarget obo:CL_0000790 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:17589542", "PMID:19169262" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000914 ; owl:annotatedTarget "An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000915 ; owl:annotatedTarget obo:CL_0000797 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:11685222" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000915 ; owl:annotatedTarget "An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000916 ; owl:annotatedTarget obo:CL_0000800 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:11976459" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000916 ; owl:annotatedTarget "A mature gamma-delta T cell located in the epidermis that regulates wound healing." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000917 ; owl:annotatedTarget obo:CL_0000908 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:22343568", "PMID:9914231" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000917 ; owl:annotatedTarget "A CD8-positive, alpha-beta positive T cell that has the phenotype T-bet-positive, eomesodermin-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000917 ; owl:annotatedTarget "Tc1 CD8+ T cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000918 ; owl:annotatedTarget obo:CL_0000908 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:9914231" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000918 ; owl:annotatedTarget "A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000919 ; owl:annotatedTarget obo:CL_0000795 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19118505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000919 ; owl:annotatedTarget "A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000920 ; owl:annotatedTarget obo:CL_0000795 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19118505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000920 ; owl:annotatedTarget "CD8-positive, alpha-beta positive regulatory T cell with the phenotype CD28-negative and FoxP3-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000921 ; owl:annotatedTarget obo:CL_0000814 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:15039760" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000921 ; owl:annotatedTarget "An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000922 ; owl:annotatedTarget obo:CL_0000814 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:15039760" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000922 ; owl:annotatedTarget "An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000923 ; owl:annotatedTarget obo:CL_0000921 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:17303398" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000923 ; owl:annotatedTarget "A type I NK T cell that has the phenotype CD4-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000924 ; owl:annotatedTarget obo:CL_0000921 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:18997862" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000924 ; owl:annotatedTarget "A type I NK T cell that has the phenotype CD4-negative and CD8-negative." . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:17303398" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000925 ; owl:annotatedTarget "A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers." . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:17303398" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000926 ; owl:annotatedTarget "A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses." . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000927 ; owl:annotatedTarget "A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses." . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:17303398" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000928 ; owl:annotatedTarget "A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers." . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:17303398" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000929 ; owl:annotatedTarget "A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses." . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:17303398" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000930 ; owl:annotatedTarget "A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000931 ; owl:annotatedTarget obo:CL_0000922 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:17964217" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000931 ; owl:annotatedTarget "A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000932 ; owl:annotatedTarget obo:CL_0000922 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:17964217" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000932 ; owl:annotatedTarget "A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000933 ; owl:annotatedTarget obo:CL_0000922 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:17964217" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000933 ; owl:annotatedTarget "A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000934 ; owl:annotatedTarget obo:CL_0000624 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:18440213" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000934 ; owl:annotatedTarget "A CD4-positive, alpha-beta T cell that has cytotoxic function." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000935 ; owl:annotatedTarget obo:CL_0000797 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:11685222" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000935 ; owl:annotatedTarget "A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000092 ; owl:annotatedTarget obo:CL_0000766 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000092 ; owl:annotatedTarget obo:CL_0001035 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000936 ; owl:annotatedTarget obo:CL_0000837 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000936 ; owl:annotatedTarget "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000936 ; owl:annotatedTarget "ELP" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "PMID:10428500", "PMID:15055519", "PMID:17380158" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000092 ; owl:annotatedTarget "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." . [] oboInOwl:hasDbXref "PMID:18371378" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000936 ; owl:annotatedTarget "GMLP" . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000936 ; owl:annotatedTarget "LMPP" . [] oboInOwl:hasDbXref "DOI:10.3389/fmed.2017.00234", "DOI:10.37175/stemedicine.v1i4.57", "https://www.sciencedirect.com/topics/medicine-and-dentistry/osteoclast" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000092 ; owl:annotatedTarget """Osteoclasts, derived from the monocyte/macrophage lineage, play a crucial role in bone remodeling through bone resorption. They are distinguished from other cells by their large size and their unique ability to secrete enzymes and acids that dissolve the calcium phosphate in bone. The formation of osteoclasts is influenced by two primary factors: macrophage colony-stimulating factor (M-CSF) and the ligand-activated receptor (RANKL) of nuclear factor kappa B (NF-κB). Osteoclasts also collaborate with osteoblasts, responsible for new bone formation, to maintain bone health and adapt bone structure. Their coordinated actions allow continuous remodeling while preserving overall bone strength and integrity. Imbalances in osteoclast activity can lead to pathological conditions. For example, excessive activity may contribute to diseases like osteoporosis, periprosthetic osteolysis, bone tumors, and Paget's disease. Other the other hand, osteoclast deficiency ca result in conditions like osteopetrosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:17100874" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000937 ; owl:annotatedTarget "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000092 ; owl:annotatedTarget "ZFA:0009047" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "osteoclast on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000092 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000092" . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19796267", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000938 ; owl:annotatedTarget "NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000938 ; owl:annotatedTarget "CD16-CD56bright NK cell" . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:19796267", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000939 ; owl:annotatedTarget "A mature natural killer cell that has the phenotype CD56-low, CD16-positive and which is capable of cytotoxicity and cytokine production." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000939 ; owl:annotatedTarget "CD16+CD56+ NK cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000940 ; owl:annotatedTarget obo:CL_0000791 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19416870" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000940 ; owl:annotatedTarget "An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000941 ; owl:annotatedTarget obo:CL_0000990 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:19273629" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000941 ; owl:annotatedTarget "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000942 ; owl:annotatedTarget obo:CL_0000784 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19941119" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000942 ; owl:annotatedTarget "A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM322.LZLG.752" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000942 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000000 ; owl:annotatedTarget "ZFA:0009000" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000943 ; owl:annotatedTarget obo:CL_0000968 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMID:11101868", "PMID:20224569" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000943 ; owl:annotatedTarget "A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma." . [] oboInOwl:hasDbXref "PMID:11101868", "PMID:20224569" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000943 ; owl:annotatedTarget "B effector 1 cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000944 ; owl:annotatedTarget obo:CL_0000968 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMID:11101868", "PMID:20224569" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000944 ; owl:annotatedTarget "A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6." . [] oboInOwl:hasDbXref "PMID:11101868", "PMID:20224569" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000944 ; owl:annotatedTarget "B effector 2 cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000945 ; owl:annotatedTarget obo:CL_0000542 . [] oboInOwl:hasDbXref "GOC:add", "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000945 ; owl:annotatedTarget "A lymphocyte of B lineage with the commitment to express an immunoglobulin complex." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000946 ; owl:annotatedTarget obo:CL_0000945 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0721601464", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000946 ; owl:annotatedTarget "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000947 ; owl:annotatedTarget obo:CL_0000974 . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031", "ISBN:781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000947 ; owl:annotatedTarget "A long lived plasma cell that secretes IgE." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000948 ; owl:annotatedTarget obo:CL_0000972 . [] oboInOwl:hasDbXref "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000948 ; owl:annotatedTarget "A class switched memory B cell that expresses IgE on the cell surface." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000949 ; owl:annotatedTarget obo:CL_0000980 . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000949 ; owl:annotatedTarget "A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000950 ; owl:annotatedTarget obo:CL_0000980 . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000950 ; owl:annotatedTarget "A plasmablast that secretes IgE." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000951 ; owl:annotatedTarget obo:CL_0000975 . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031", "ISBN:781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000951 ; owl:annotatedTarget "A short lived plasma cell that secretes IgE." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000952 ; owl:annotatedTarget obo:CL_0000957 . [] oboInOwl:hasDbXref "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "PMID:9785673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000952 ; owl:annotatedTarget "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000953 ; owl:annotatedTarget obo:CL_0000957 . [] oboInOwl:hasDbXref "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "PMID:9785673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000953 ; owl:annotatedTarget "A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000954 ; owl:annotatedTarget obo:CL_0000955 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:18432934", "PMID:9785673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000954 ; owl:annotatedTarget "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000955 ; owl:annotatedTarget obo:CL_0000817 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "PMID:9785673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000955 ; owl:annotatedTarget "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000956 ; owl:annotatedTarget obo:CL_0000817 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:18432934", "PMID:20839338", "PMID:9785673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000956 ; owl:annotatedTarget "A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein." . [] oboInOwl:hasDbXref "PMID:11244048" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000956 ; owl:annotatedTarget "pro-B cell (Philadelphia nomenclature)" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000957 ; owl:annotatedTarget obo:CL_0000955 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "PMID:16551251", "PMID:18432934", "PMID:9785673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000957 ; owl:annotatedTarget "A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative." . [] oboInOwl:hasDbXref "PMID:11244048" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000957 ; owl:annotatedTarget "large pre-B cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000958 ; owl:annotatedTarget obo:CL_0000818 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2193793", "PMID:12810111" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000958 ; owl:annotatedTarget "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000094 ; owl:annotatedTarget obo:CL_0000766 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000959 ; owl:annotatedTarget obo:CL_0000818 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2193793", "PMID:12810111" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000959 ; owl:annotatedTarget "A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive." . [] oboInOwl:hasDbXref "GOC:amm", "GOC:tfm", "MESH:D006098", "http://en.wikipedia.org/wiki/Granulocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000094 ; owl:annotatedTarget "A leukocyte with abundant granules in the cytoplasm." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000094 ; owl:annotatedTarget "ZFA:0009048" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000960 ; owl:annotatedTarget obo:CL_0000818 . [] oboInOwl:hasDbXref "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMID:12810111", "PMID:17174121", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000960 ; owl:annotatedTarget "A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM)." . [] oboInOwl:hasDbXref "PMID:17174121" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000960 ; owl:annotatedTarget "An1 B cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000961 ; owl:annotatedTarget obo:CL_0000843 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GO_REF:0000031", "PMID:17992590", "PMID:18432934", "PMID:8006591" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000961 ; owl:annotatedTarget "A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000962 ; owl:annotatedTarget obo:CL_0000843 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GO_REF:0000031", "PMID:17992590", "PMID:18432934", "PMID:8006591" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000962 ; owl:annotatedTarget "A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000963 ; owl:annotatedTarget obo:CL_0000844 . [] oboInOwl:hasDbXref "GOC:add", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMID:9280752" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000963 ; owl:annotatedTarget "A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000964 ; owl:annotatedTarget obo:CL_0000844 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMID:17992590", "PMID:18432934", "PMID:8006591" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000964 ; owl:annotatedTarget "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000965 ; owl:annotatedTarget obo:CL_0000844 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GO_REF:0000031", "PMID:18432934", "PMID:8006591" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000965 ; owl:annotatedTarget "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." . [] oboInOwl:hasDbXref "PMID:8006591" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000965 ; owl:annotatedTarget "centroblast" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000966 ; owl:annotatedTarget obo:CL_0000844 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GO_REF:0000031", "PMID:18432934", "PMID:8006591" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000966 ; owl:annotatedTarget "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor." . [] oboInOwl:hasDbXref "PMID:17992590" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000966 ; owl:annotatedTarget "centrocyte" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMID:18432934", "PMID:8006591" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000967 ; owl:annotatedTarget "A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000968 ; owl:annotatedTarget obo:CL_0000785 . [] oboInOwl:hasDbXref "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMID:11101868", "PMID:20224569" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000968 ; owl:annotatedTarget "A mature B cell that produces cytokines that can influence CD4 T cell differentiation." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000969 ; owl:annotatedTarget obo:CL_0000785 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "MESH:D060151", "PMID:11869683", "PMID:18482568", "PMID:20224569", "PMID:20809522" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000969 ; owl:annotatedTarget "A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000970 ; owl:annotatedTarget obo:CL_0000787 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196", "PMID:20933013", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000970 ; owl:annotatedTarget "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000970 ; owl:annotatedTarget "IgD+ memory B cell" . [] oboInOwl:hasDbXref "HP:0032126" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000970 ; owl:annotatedTarget "non-class-switched memory B cell" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196", "PMID:19447676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000971 ; owl:annotatedTarget "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000972 ; owl:annotatedTarget obo:CL_0000787 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196", "PMID:20933013", "PMID:9295047" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000972 ; owl:annotatedTarget "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000973 ; owl:annotatedTarget obo:CL_0000972 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GO_REF:0000031", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000973 ; owl:annotatedTarget "A class switched memory B cell that expresses IgA." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000974 ; owl:annotatedTarget obo:CL_0000786 . [] oboInOwl:hasDbXref "GOC:msz", "GOC:tfm", "GO_REF:0000031", "ISBN:9780781765190", "PMID:16014527" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000974 ; owl:annotatedTarget "A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000975 ; owl:annotatedTarget obo:CL_0000786 . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031", "PMID:16014527" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000975 ; owl:annotatedTarget "A fully differentiated plasma cell that lives for months." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000976 ; owl:annotatedTarget obo:CL_0000975 . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031", "ISBN:781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000976 ; owl:annotatedTarget "A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000977 ; owl:annotatedTarget obo:CL_0000975 . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031", "ISBN:781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000977 ; owl:annotatedTarget "A short lived plasma cell that secretes IgG." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000978 ; owl:annotatedTarget obo:CL_0000975 . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031", "ISBN:781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000978 ; owl:annotatedTarget "A short lived plasma cell that secretes IgM." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000979 ; owl:annotatedTarget obo:CL_0000972 . [] oboInOwl:hasDbXref "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000979 ; owl:annotatedTarget "An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000980 ; owl:annotatedTarget obo:CL_0000785 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2673126" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000980 ; owl:annotatedTarget "An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative." . [] oboInOwl:hasDbXref "GOC:msz", "GOC:tfm", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000981 ; owl:annotatedTarget "A memory B cell with the phenotype IgD-negative and CD27-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000982 ; owl:annotatedTarget obo:CL_0000980 . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000982 ; owl:annotatedTarget "A plasmablast that secretes IgG." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000983 ; owl:annotatedTarget obo:CL_0000980 . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000983 ; owl:annotatedTarget "A plasmablast that secretes IgM." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000984 ; owl:annotatedTarget obo:CL_0000980 . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000984 ; owl:annotatedTarget "A plasmablast that secretes IgA." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000985 ; owl:annotatedTarget obo:CL_0000974 . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031", "ISBN:781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000985 ; owl:annotatedTarget "A fully differentiated plasma cell that secretes IgG." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000986 ; owl:annotatedTarget obo:CL_0000974 . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031", "ISBN:781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000986 ; owl:annotatedTarget "A fully differentiated plasma cell that secretes IgM." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000987 ; owl:annotatedTarget obo:CL_0000974 . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031", "ISBN:781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000987 ; owl:annotatedTarget "A fully differentiated plasma cell that secretes IgA." . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000988 ; owl:annotatedTarget "A cell of a hematopoietic lineage." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000988 ; owl:annotatedTarget "ZFA:0005830" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000989 ; owl:annotatedTarget obo:CL_0000784 . [] oboInOwl:hasDbXref "GOC:amm", "GOC:dsd", "GO_REF:0000031", "PMID:15771572", "PMID:17850486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000989 ; owl:annotatedTarget "CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000990 ; owl:annotatedTarget obo:CL_0000451 . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMID:17850486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000990 ; owl:annotatedTarget "Conventional dendritic cell is a dendritic cell that is CD11c-high." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000991 ; owl:annotatedTarget obo:CL_0000784 . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMID:15771572", "PMID:17850486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000991 ; owl:annotatedTarget "CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD45RA-positive, CD85g-positive(ILT7), CD123-positive, CD303-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000992 ; owl:annotatedTarget obo:CL_0000989 . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMID:15771572", "PMID:17850486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000992 ; owl:annotatedTarget "Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD80-low and CD86-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000993 ; owl:annotatedTarget obo:CL_0000989 . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMID:15771572", "PMID:17850486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000993 ; owl:annotatedTarget "Mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD83-high and is CD80-positive, CD86-positive, and MHCII-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000994 ; owl:annotatedTarget obo:CL_0000991 . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMID:15771572", "PMID:17850486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000994 ; owl:annotatedTarget "Immature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-negative, CD86-low and MHCII-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000996 ; owl:annotatedTarget obo:CL_0000991 . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMID:15771572", "PMID:17850486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000996 ; owl:annotatedTarget "Mature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000997 ; owl:annotatedTarget obo:CL_0000999 . [] oboInOwl:hasDbXref "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2346585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000997 ; owl:annotatedTarget "Immature CD8-alpha-negative CD11b-positive dendritic cell is a CD8-alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000998 ; owl:annotatedTarget obo:CL_0000990 . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMCID:PMC2346585", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000998 ; owl:annotatedTarget "CD8-alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8-alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells." . [] oboInOwl:hasDbXref "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2346585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000999 ; owl:annotatedTarget "CD8-alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8-alpha-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001000 ; owl:annotatedTarget obo:CL_0000990 . [] oboInOwl:hasDbXref "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2346585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001000 ; owl:annotatedTarget "CD8-alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8-alpha-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001001 ; owl:annotatedTarget obo:CL_0000998 . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMCID:PMC2346585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001001 ; owl:annotatedTarget "Immature CD8-alpha-negative CD11b-negative dendritic cell is a CD8-alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001002 ; owl:annotatedTarget obo:CL_0000998 . [] oboInOwl:hasDbXref "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2346585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001002 ; owl:annotatedTarget "Mature CD8-alpha-negative CD11b-negative dendritic cell is a CD8-alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001003 ; owl:annotatedTarget obo:CL_0000999 . [] oboInOwl:hasDbXref "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2346585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001003 ; owl:annotatedTarget "Mature CD8-alpha-negative CD11b-positive dendritic cell is a CD8-alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001004 ; owl:annotatedTarget obo:CL_0001000 . [] oboInOwl:hasDbXref "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2346585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001004 ; owl:annotatedTarget "Immature CD8-alpha-positive CD11b-negative dendritic cell is a CD8-alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001005 ; owl:annotatedTarget obo:CL_0001000 . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMCID:PMC2346585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001005 ; owl:annotatedTarget "Mature CD8-alpha-positive CD11b-negative dendritic cell is a CD8-alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMCID:PMC2346585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001006 ; owl:annotatedTarget "Dermal dendritic cell is a conventional dendritic cell that is CD11b-positive, CD205-positive and CD8 alpha-negative." . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMID:17850486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001007 ; owl:annotatedTarget "Interstitial dendritic cell is a conventional dendritic cell that is CD11b-positive, CD1a-positive, CD206-positive, CD209-positive, and CD36-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000096 ; owl:annotatedTarget obo:CL_0000775 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "MESH:D009504", "PMID:11138776", "PMID:12560239", "PMID:15514007", "PMID:7880385", "http://www.cap.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000096 ; owl:annotatedTarget "A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000096 ; owl:annotatedTarget "ZFA:0009049" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001008 ; owl:annotatedTarget obo:CL_0000037 . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:17952047", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001008 ; owl:annotatedTarget "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001009 ; owl:annotatedTarget obo:CL_0001006 . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMCID:PMC2346585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001009 ; owl:annotatedTarget "Immature dermal dendritic cell is a dermal dendritic cell that is CD80-low, CD86-low, and MHCII-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001010 ; owl:annotatedTarget obo:CL_0001006 . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMCID:PMC2346585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001010 ; owl:annotatedTarget "Mature dermal dendritic cell is a dermal dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001011 ; owl:annotatedTarget obo:CL_0001007 . [] oboInOwl:hasDbXref "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:17850486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001011 ; owl:annotatedTarget "Immature interstitial dendritic cell is a interstitial dendritic cell that is CD80-low, CD86-low, and MHCII-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001013 ; owl:annotatedTarget obo:CL_0001007 . [] oboInOwl:hasDbXref "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:17850486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001013 ; owl:annotatedTarget "Mature interstitial dendritic cell is a interstitial dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001014 ; owl:annotatedTarget obo:CL_0000453 . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMID:17850486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001014 ; owl:annotatedTarget "CD1a-positive Langerhans cell is a Langerhans_cell that is CD1a-positive and CD324-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001015 ; owl:annotatedTarget obo:CL_0000453 . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMCID:PMC2346585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001015 ; owl:annotatedTarget "CD8-alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8-alpha-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001016 ; owl:annotatedTarget obo:CL_0001014 . [] oboInOwl:hasDbXref "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:17850486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001016 ; owl:annotatedTarget "Immature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-low, CD86-low, and MHCII-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001017 ; owl:annotatedTarget obo:CL_0001014 . [] oboInOwl:hasDbXref "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:17850486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001017 ; owl:annotatedTarget "Mature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001018 ; owl:annotatedTarget obo:CL_0001015 . [] oboInOwl:hasDbXref "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2346585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001018 ; owl:annotatedTarget "Immature CD8-alpha-low Langerhans cell is a CD8-alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001020 ; owl:annotatedTarget obo:CL_0001015 . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMCID:PMC2346585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001020 ; owl:annotatedTarget "Mature CD8-alpha-low Langerhans cell is a CD8-alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive." . [] oboInOwl:hasDbXref "ReO:mhb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000001 ; owl:annotatedTarget "A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged." . [] oboInOwl:hasDbXref "MESH:D013087" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000018 ; owl:annotatedTarget "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001021 ; owl:annotatedTarget obo:CL_0000051 . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2346585", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001021 ; owl:annotatedTarget "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001022 ; owl:annotatedTarget obo:CL_0000576 . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GO_REF:0000031", "PMID:17952047" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001022 ; owl:annotatedTarget "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001023 ; owl:annotatedTarget obo:CL_0001059 . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:1261582", "PMID:17952047", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001023 ; owl:annotatedTarget "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001024 ; owl:annotatedTarget obo:CL_0000037 . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:10430905", "PMID:11750107", "PMID:16551251", "PMID:20024907", "PMID:9389721" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001024 ; owl:annotatedTarget "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." . [] oboInOwl:hasDbXref "PMID:16140871" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001024 ; owl:annotatedTarget "CD133-positive hematopoietic stem cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001025 ; owl:annotatedTarget obo:CL_0000051 . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:17952047", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001025 ; owl:annotatedTarget "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000018 ; owl:annotatedTarget "FBbt:00004942" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GO_REF:0000031", "PMCID:PMC2626675", "PMID:16551251" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001026 ; owl:annotatedTarget "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001027 ; owl:annotatedTarget obo:CL_0000051 . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMID:16551251" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001027 ; owl:annotatedTarget "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001028 ; owl:annotatedTarget obo:CL_0000051 . [] oboInOwl:hasDbXref "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:19491395" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001028 ; owl:annotatedTarget "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." . [] oboInOwl:hasDbXref "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:17922016", "PMID:19286519" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001029 ; owl:annotatedTarget "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." . [] oboInOwl:hasDbXref "PMID:21219184" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001029 ; owl:annotatedTarget "CDP" . [] oboInOwl:hasDbXref "PMID:21219184" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001029 ; owl:annotatedTarget "pro-DCs" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000018 ; owl:annotatedTarget "ZFA:0005769" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:mah", "doi:10.12688/f1000research.15021.1", "doi:10.3389/fncir.2020.611841" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001031 ; owl:annotatedTarget "An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. A mature cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0001031 ; owl:annotatedTarget "ZFA:0001691" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "doi:10.3389/fncir.2020.611841" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001031 ; owl:annotatedTarget "granule cell of the cerebellum" . [] oboInOwl:hasDbXref "doi:10.3389/fncir.2020.611841" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0001031 ; owl:annotatedTarget "It has been noted in at least some mammalian species that granule cells are the most numerous cell type in the cerebellum and in the brain, with at least 99% of all cerebellar neurons being granule cells." . [] dc:license ; oboInOwl:hasDbXref "doi:10.1016/j.cnp.2022.11.002" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0001031 ; owl:annotatedTarget . [] dc:license ; oboInOwl:hasDbXref "doi:10.3389/fnins.2020.00293" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0001031 ; owl:annotatedTarget . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001032 ; owl:annotatedTarget "Granule cell that is part of the cerebral cortex." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001033 ; owl:annotatedTarget "Granule cell with a soma found in the hippocampus." . [] oboInOwl:hasDbXref "ReO:mhb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001034 ; owl:annotatedTarget "A cell that is maintained or propagated in a controlled artificial environment for use in an investigation." . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001035 ; owl:annotatedTarget "A connective tissue cell found in bone." . [] oboInOwl:hasDbXref "DOI:10.1007/s00795-015-0099-y", "DOI:10.1007/s11914-012-0105-4", "DOI:10.1016/j.jot.2021.04.005", "DOI:10.1038/s41413-020-0099-y" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0001035 ; owl:annotatedTarget """Bone cells, also known as osteocytes, form the building blocks of the skeletal system. They represent the most common type of bone cell, making up approximately 95% of the total bone cell population in mature adult bone tissue. Osteocytes are a stellate shape with numerous long, slender dendritic processes. The formation of bone is a complex process involving the action of osteoclasts - cells that break down and reabsorb old bone, followed by osteoblasts that rebuild the bone. Osteocytes serve as coordinators for these two types of bone cells to ensure a balance in the bone remodeling process, contributing to maintaining both bone strength and mineral homeostasis. The primary functions of osteocytes involve the creation, maintenance, and repair of bone tissue. They ensure that bone remodeling is performed by forming a network within the bone and communicating with other cells to help them respond to mechanical strain and damage. A remarkable aspect of osteocytes is their ability to perceive mechanical forces, translating them into biochemical signals that regulate bone remodeling and adaptation. Defects in osteocyte function, aside from other bone cells, have been associated with several bone disorders such as osteoporosis, renal osteodystrophy, and skeletal manifestations of diabetes. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "bone cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0001035 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0001035" . [] oboInOwl:hasDbXref "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001039 ; owl:annotatedTarget "Osteoblast that is terminally differentiated, located adjacent to acellular or cellular bone tissue within periosteum, and is capable of mineralizing the matrix." . [] oboInOwl:hasDbXref "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001040 ; owl:annotatedTarget "Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001041 ; owl:annotatedTarget obo:CL_0000795 . [] oboInOwl:hasDbXref "GOC:dsd", "PMID:19609979" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001041 ; owl:annotatedTarget "A CD8-positive alpha-beta-positive T cell with the phenotype CXCR3-positive and having suppressor function. They are capable of producing IL-10, suppressing proliferation, and suppressing IFN-gamma production." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001042 ; owl:annotatedTarget obo:CL_0000492 . [] oboInOwl:hasDbXref "GOC:dsd", "PMID:19578368", "PMID:19578369" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001042 ; owl:annotatedTarget "CD4-positive, alpha-beta T cell that produces IL-22." . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001043 ; owl:annotatedTarget "A recently activated CD4-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0001043 ; owl:annotatedTarget "activated CD4+ T cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000097 ; owl:annotatedTarget obo:CL_0000766 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:068340007X", "MESH:D008407", "PMCID:PMC1312421", "PMCID:PMC2855166", "PMID:15153310", "PMID:16455980", "PMID:19671378", "PMID:212366338", "PMID:9354811" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000097 ; owl:annotatedTarget "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001044 ; owl:annotatedTarget "A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0001044 ; owl:annotatedTarget "effector CD4+ T cell" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000097 ; owl:annotatedTarget "labrocyte" . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001045 ; owl:annotatedTarget "A naive regulatory T cell with the phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-negative." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001045 ; owl:annotatedTarget "naive CCR4+ Treg" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000097 ; owl:annotatedTarget "mastocyte" . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001046 ; owl:annotatedTarget "A memory regulatory T cell with phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-positive." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001046 ; owl:annotatedTarget "memory CCR4+ Treg" . [] oboInOwl:hasDbXref "ISBN:068340007X" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000097 ; owl:annotatedTarget "tissue basophil" . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001047 ; owl:annotatedTarget "A CD4-positive, CD25-positive, alpha-beta regulatory T cell with the additional phenotype CCR4-positive." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001047 ; owl:annotatedTarget "CCR+ Treg" . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001048 ; owl:annotatedTarget "A CD4-positive, CD25-positive, CCR4-positive, alpha-beta T regulatory cell with the phenotype HLA-DRA-positive, indicating recent activation." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001048 ; owl:annotatedTarget "activated CCR4+ Treg" . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001049 ; owl:annotatedTarget "A recently activated CD8-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, CCR7-negative, and CD25-positive." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0001049 ; owl:annotatedTarget "activated CD8+ T cell" . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001050 ; owl:annotatedTarget "A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0001050 ; owl:annotatedTarget "effector CD8+ T cell" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000098 ; owl:annotatedTarget "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001051 ; owl:annotatedTarget "A CD4-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0001051 ; owl:annotatedTarget "non-Th1/Th17 CD4+ T cell" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000098 ; owl:annotatedTarget "ZFA:0009050" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001052 ; owl:annotatedTarget "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0001052 ; owl:annotatedTarget "non-Tc1/Tc17 CD8+ T cell" . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001053 ; owl:annotatedTarget "A memory B cell that lacks expression of surface IgD." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001053 ; owl:annotatedTarget "IgD- memory B cell" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D007395" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000099 ; owl:annotatedTarget "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001054 ; owl:annotatedTarget "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_0001054 ; owl:annotatedTarget "monocyte" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000019 ; owl:annotatedTarget obo:CL_0000408 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000099 ; owl:annotatedTarget "FBbt:00005125" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "PMID:20628149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001055 ; owl:annotatedTarget "An intermediate monocyte that is CD14-positive and with low amounts of CD16." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000099 ; owl:annotatedTarget "ZFA:0009051" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001056 ; owl:annotatedTarget "A dendritic cell with the phenotype HLA-DRA-positive." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0001056 ; owl:annotatedTarget "dendritic cell" . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001057 ; owl:annotatedTarget "A myeloid dendritic cell with the phenotype HLA-DRA-positive." . [] oboInOwl:hasDbXref "MESH:D009046", "PMID:16875686" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000100 ; owl:annotatedTarget "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0001057 ; owl:annotatedTarget "myeloid dendritic cell" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000100 ; owl:annotatedTarget "FBbt:00005123" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001058 ; owl:annotatedTarget "A plasmacytoid dendritic cell with the phenotype HLA-DRA-positive, CD123-positive, and CD11c-negative." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0001058 ; owl:annotatedTarget "plasmacytoid dendritic cell" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000100 ; owl:annotatedTarget "ZFA:0009052" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0878932437", "PMCID:PMC2212039", "PMID:10724173", "PMID:16551251", "PMID:16647566" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001059 ; owl:annotatedTarget "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." . [] oboInOwl:hasDbXref "ISBN:0878932437" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0001059 ; owl:annotatedTarget "CFU-GEMM" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0001059 ; owl:annotatedTarget "CFU-S" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0001059 ; owl:annotatedTarget "CMP" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0001059 ; owl:annotatedTarget "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0001059 ; owl:annotatedTarget "multipotential myeloid stem cell" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0001059 ; owl:annotatedTarget "myeloid stem cell" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0001059 ; owl:annotatedTarget "pluripotent stem cell (bone marrow)" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D013094" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000019 ; owl:annotatedTarget "A mature male germ cell that develops from a spermatid." . [] oboInOwl:hasDbXref "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000101 ; owl:annotatedTarget "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001060 ; owl:annotatedTarget "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000101 ; owl:annotatedTarget "FBbt:00005124" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "GOC:cg", "GOC:wdd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001061 ; owl:annotatedTarget "A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000101 ; owl:annotatedTarget "ZFA:0009053" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "GOC:dos", "PMID:15032595", "PMID:16237082", "PMID:26883338" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001062 ; owl:annotatedTarget "A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." . [] oboInOwl:hasDbXref "PMID:15032595" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0001062 ; owl:annotatedTarget "TEMRA" . [] oboInOwl:hasDbXref "PMID:23749412", "PMID:36381588" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000102 ; owl:annotatedTarget "A neuron type that respond to multiple stimuli such as mechanical, thermal and chemical. This neuron type is responsible for integrating different types of sensory inputs, allowing organisms to respond appropriately to diverse environmental challenges." . [] oboInOwl:hasDbXref "PMID:15032595" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001062 ; owl:annotatedTarget "CD8+ TEMRA" . [] oboInOwl:hasDbXref "PMID:15032595" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001062 ; owl:annotatedTarget "CD8-positive TEMRA" . [] oboInOwl:hasDbXref "GOC:add", "GOC:cg", "GOC:wdd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001063 ; owl:annotatedTarget "An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000102 ; owl:annotatedTarget "ZFA:0009054" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "GOC:cg", "GOC:wdd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001064 ; owl:annotatedTarget "A neoplastic cell that is capable of entering a surrounding tissue" . [] oboInOwl:hasDbXref "PMID:23749412" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000102 ; owl:annotatedTarget "polymodal sensory neuron" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "PMID:23292121", "PMID:23348417" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001065 ; owl:annotatedTarget "A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses." . [] oboInOwl:hasDbXref "DOI:10.1080/19420889.2015.1017156", "DOI:10.1152/physrev.00009.2020", "https://www.ncbi.nlm.nih.gov/books/NBK26914/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000019 ; owl:annotatedTarget """Sperm cells, also known as spermatozoa or male gametes, are highly specialized cells that are pivotal for sexual reproduction in animals. Produced in the male reproductive organs, specifically the testes, sperm cells play an important role in the process of fertilization, where they fuse with a female gamete or egg cell (ovum) to form a zygote, which marks the beginning of a new organism. Sperm cells hold several unique traits that set them apart from other body cells. Structurally, a sperm cell possesses two main structures: the head, containing the nucleus carrying the paternal genetic information, and the flagellum, which generates energy and grants the sperm cell mobility The process of fertilization occurs when one sperm cell successfully penetrates the egg, delivering its genetic information, and ultimately leading to the formation of a new individual combining both paternal and maternal genetic materials. Notably, while hundreds of millions of sperm cells may be released during ejaculation, only one has the opportunity to successfully fertilize the egg, underscoring the highly competitive nature of this biological process. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001066 ; owl:annotatedTarget "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0001066 ; owl:annotatedTarget "BFU-E" . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0001066 ; owl:annotatedTarget "CFU-E" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "PMID:23348417" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001067 ; owl:annotatedTarget "An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines." . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "PMID:23292121", "PMID:23348417" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001068 ; owl:annotatedTarget "A group 1 innate lymphoid cell that is non-cytotoxic." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0444009442" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000103 ; owl:annotatedTarget "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body." . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "PMID:23292121", "PMID:23562755" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001069 ; owl:annotatedTarget "An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation." . [] oboInOwl:hasDbXref "GOC:add", "GOC:cvs", "GOC:ymb", "PMID:22796012", "PMID:25851693" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001070 ; owl:annotatedTarget "An adipocyte that is beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM322.LZLG.752" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0001070 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000103 ; owl:annotatedTarget "ZFA:0009055" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "PMID:23292121", "PMID:23348417" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001071 ; owl:annotatedTarget "An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22." . [] oboInOwl:hasDbXref "GOC:add", "PMID:30193847", "PMID:31201208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001072 ; owl:annotatedTarget "An innate lymphoid cell in the human with the phenotype CD34-negative, CD117-positive, and a precusor to NK cells, ILC2 cells, and ILC3 cells." . [] oboInOwl:hasDbXref "FMA:67287", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000104 ; owl:annotatedTarget "A neuron with three or more neurites, usually an axon and multiple dendrites." . [] oboInOwl:hasDbXref "GOC:add", "PMID:30193847", "PMID:31201208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001073 ; owl:annotatedTarget "An innate lymphoid cell in the human with the phenotype CD34-negative, CD56-positive, CD117-positive.Thie cell type may include precusors to NK cells and ILC3 cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000104 ; owl:annotatedTarget "ZFA:0009056" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FMA:67305", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000105 ; owl:annotatedTarget "Neuron with two neurites that are fused grossly when they protrude from the soma and bifurcate a short distance from the soma." . [] oboInOwl:hasDbXref "GOC:add", "PMID:30193847" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001074 ; owl:annotatedTarget "An innate lymphoid cell precursor in the human with the phenotype CD34-positive, CD56-positive, CD117-positive.Thie cell type may include precusors to NK cells and ILC3 cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000105 ; owl:annotatedTarget "ZFA:0009057" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "PMID:31201208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001075 ; owl:annotatedTarget "An innate lymphoid cell in the human with the phenotype KLRG1-positive that is a precusor for ILC2 cells." . [] oboInOwl:hasDbXref "FMA:67278", "GOC:nv" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000106 ; owl:annotatedTarget "Neuron with one neurite that extends from the cell body." . [] oboInOwl:hasDbXref "GOC:add", "PMID:31201208", "PMID:31337734" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001076 ; owl:annotatedTarget "An innate lymphoid cell in the human with the phenotype NKp46-positive that is a precusor for NK cells and ILC3 cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000106 ; owl:annotatedTarget "ZFA:0009058" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "PMID:31500958" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001077 ; owl:annotatedTarget "An ILC1 cell in the human with the phenotype CD56-negative, IL-7Ralpha-positive, T-bet-positive." . [] oboInOwl:hasDbXref "GOC:add", "PMID:31500958" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001078 ; owl:annotatedTarget "A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000019 ; owl:annotatedTarget "FBbt:00004954" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "PMID:24778151", "PMID:31500958" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001079 ; owl:annotatedTarget "A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive, and NKp44-positive." . [] oboInOwl:hasDbXref "GOC:add", "PMID:24778151", "PMID:31500958" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001080 ; owl:annotatedTarget "A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive, and NKp44-negative." . [] oboInOwl:hasDbXref "GOC:add", "PMID:24778151", "PMID:26844414" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001081 ; owl:annotatedTarget "A group 2 innate lymphoid cell in the human with the phenotype CD25-positive, CD127-positive, CD161-positive, and GATA-3-positive." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001082 ; owl:annotatedTarget "An innate lyphoid cell with an immature phenotype." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000107 ; owl:annotatedTarget "A neuron whose cell body is within an autonomic ganglion." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000107 ; owl:annotatedTarget "ZFA:0009059" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "PMID:17465678", "PMID:26883338", "PMID:27997758", "PMID:29133794" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001087 ; owl:annotatedTarget "A CD4-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." . [] oboInOwl:hasDbXref "PMID:17465678" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0001087 ; owl:annotatedTarget "TEMRA" . [] oboInOwl:hasDbXref "PMID:17465678" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001087 ; owl:annotatedTarget "CD4+ TEMRA" . [] oboInOwl:hasDbXref "PMID:17465678" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001087 ; owl:annotatedTarget "CD4-positive TEMRA" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001200 ; owl:annotatedTarget "A lymphocyte of B lineage that is CD19-positive." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001201 ; owl:annotatedTarget "A B cell that is CD19-positive." . [] oboInOwl:hasDbXref "GOC:add", "PMID:20398308" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001202 ; owl:annotatedTarget "A plasmablast that is CD86-positive." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000019 ; owl:annotatedTarget "ZFA:0009006" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001203 ; owl:annotatedTarget obo:CL_0000909 . [] oboInOwl:hasDbXref "GOC:tfm", "GO_REF:0000031", "PMID:20146720" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001203 ; owl:annotatedTarget "A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000108 ; owl:annotatedTarget "A neuron that uses acetylcholine as a vesicular neurotransmitter." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000108 ; owl:annotatedTarget "FBbt:00007173" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001204 ; owl:annotatedTarget obo:CL_0000897 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000108 ; owl:annotatedTarget "ZFA:0009060" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001204 ; owl:annotatedTarget "CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0001658 ; owl:annotatedTarget "FBbt:00004230" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000109 ; owl:annotatedTarget "ZFA:0009061" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002000 ; owl:annotatedTarget obo:CL_0001066 . [] oboInOwl:hasDbXref "PMID:23040809", "doi:10.1016/B978-012589762-4/50021-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000110 ; owl:annotatedTarget "A neuron that uses neuropeptides as transmitters." . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:19805084", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002000 ; owl:annotatedTarget "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000110 ; owl:annotatedTarget "FBbt:00004101" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002001 ; owl:annotatedTarget obo:CL_0000557 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12615892", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002001 ; owl:annotatedTarget "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000110 ; owl:annotatedTarget "ZFA:0009062" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "sperm on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000019 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000019" . [] oboInOwl:hasDbXref "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000111 ; owl:annotatedTarget "OBSOLETE A neuron that is part of nerve found outside the central nervous system." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002002 ; owl:annotatedTarget obo:CL_0000557 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12615892", "PMID:16322423", "PMID:19022770", "PMID:19273628", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002002 ; owl:annotatedTarget "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." . [] oboInOwl:hasDbXref "PMID:34696823", "PMID:37608556" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000112 ; owl:annotatedTarget "A neuron of the invertebrate central nervous system. This neuron innervates the central complex (CX) of an invertebrate brain and it forms columnar patterns with its dendrites. It is involved in navigation and spatial processing." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002003 ; owl:annotatedTarget obo:CL_0001066 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:19621348" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002003 ; owl:annotatedTarget "An erythroid progenitor cell that is CD34-positive and is GlyA-negative." . [] oboInOwl:hasDbXref "PMID:18837039", "PMID:32374034", "PMID:34696823", "PMID:37608556", "PMID:9153131" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0000112 ; owl:annotatedTarget "Columnar neurons have been widely studied in Diptera, locusts, honey bees and other insects. In the mammalian brain, a \"columnar organisation\" is referred to neurons of the neocortex, however these differ from columnar neurons which are found in the insects central nervous system." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002004 ; owl:annotatedTarget obo:CL_0000547 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:19621348" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002004 ; owl:annotatedTarget "A proerythoblast that is CD34-negative and GlyA-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002005 ; owl:annotatedTarget obo:CL_0000050 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12615892", "PMID:190227700" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002005 ; owl:annotatedTarget "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002006 ; owl:annotatedTarget obo:CL_0000050 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12615892", "PMID:19022770", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002006 ; owl:annotatedTarget "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000113 ; owl:annotatedTarget obo:CL_0000518 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002007 ; owl:annotatedTarget obo:CL_0000611 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000113 ; owl:annotatedTarget "A vertebrate phagocyte with a single nucleus." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:17582345" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002007 ; owl:annotatedTarget "A lineage marker-negative, CD34-positive, IL5r-alpha-positive, and Sca1-negative eosinophil progenitor cell." . [] oboInOwl:hasDbXref "ReO:mhb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000002 ; owl:annotatedTarget "OBSOLETE: A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite growth/propagation in vitro as part of a immortal cell line." . [] oboInOwl:hasDbXref "DOI:10.1016/j.coi.2005.11.008", "DOI:10.1038/nri3087", "DOI:10.3389/fimmu.2019.01893" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000113 ; owl:annotatedTarget """Mononuclear phagocytes are immune cells that form a critical part of the body's innate immune system, the body's first line of defense against infections. Mononuclear phagocytes are characterized by the presence of a single, large nucleus. The ‘Mononuclear Phagocyte System’ nomenclature was introduced to distinguish mononuclear monocytes and macrophages from other cells with multiple nuclei. However, the cells within the mononuclear phagocyte system represent a highly heterogeneous group, all of which are able to perform highly efficient phagocytosis - engulfing and digesting microbes and cellular debris to fight infections and to maintain normal tissue homeostasis. In addition to phagocytosis, mononuclear phagocytes also secrete chemical compounds to recruit other immune cells to a site of infection. These cells produce different types of signaling molecules, including cytokines, chemokines, and reactive oxygen species, triggering a cascade of responses to ensure rapid and efficient containment and neutralization of invading pathogens. These cells are also involved in antigen presentation, a process essential for stimulating an adaptive immune response. They can process and present antigens to T cells, thereby linking the innate and adaptive immune responses. Mononuclear phagocytes play key roles in tissue repair and remodeling. After infection or injury, these cells help in the clearance of dead cells and debris, a crucial step in the initiation of tissue remodeling and the resolution of inflammation. Overall, mononuclear phagocytes are versatile cells that have tailored their functions to meet the unique challenges of different tissues within the body. They are pivotal in homeostasis, immunity, and inflammation, making them important aspects in a range of human diseases including infection, autoimmunity, and cancer. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002008 ; owl:annotatedTarget obo:CL_0000611 . [] oboInOwl:hasDbXref "GOC:tfm", "PMCID:PMC2626675" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002008 ; owl:annotatedTarget "A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000113 ; owl:annotatedTarget "ZFA:0009064" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002009 ; owl:annotatedTarget obo:CL_0002032 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19273628" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002009 ; owl:annotatedTarget "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." . [] a owl:Axiom ; rdfs:label "mononuclear phagocyte on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000113 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000113" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002010 ; owl:annotatedTarget obo:CL_0002031 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002010 ; owl:annotatedTarget "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." . [] oboInOwl:hasDbXref "PMID:7892198", "Wikipedia:Surface_ectoderm", "doi:/10.1101/2024.07.02.601324" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000114 ; owl:annotatedTarget "An ectodermal cell that is part of the external ectoderm, forming the outermost layer of the developing embryo. It is characterized by its polarized nature, with distinct apical and basal surfaces (Ferrante Jr., Reinke, & Stanley, 1995). Surface ectodermal cell gives rise to the epidermis, hair follicles, nails, sensory organs, and specialized structures like the apical ectodermal ridge crucial for limb development (Skoufa et al., 2024)." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002011 ; owl:annotatedTarget obo:CL_0002009 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19273628" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002011 ; owl:annotatedTarget "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." . [] oboInOwl:hasDbXref "DOI:10.1038/srep32007", "https://www.ncbi.nlm.nih.gov/books/NBK539836/", "https://www.ncbi.nlm.nih.gov/books/NBK563130" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000114 ; owl:annotatedTarget """Surface ectoderm cells give rise to external structures such as the epidermis, hair, nails, and sweat glands. They are critical during the early stages of embryonic development, where they delineate and create the organism's exterior body plan. Beyond forming the organism's physical exterior, surface ectodermal cells have other significant roles. For instance, these cells lead to the development of the anterior pituitary gland and the enamel of the teeth. They are also integral to the formation of the sensory organs, including the eyes and the ears. In the eyes, they form the cornea and lens epithelium. In the ears, they form the external ear canal and certain parts of the inner ear. Therefore, these cells are instrumental in the development of various sensory systems in an organism. Certain abnormalities or mutations in surface ectodermal cells could lead to medical conditions known as ectodermal dysplasias. These are a group of inherited disorders affecting the development or function of teeth, hair, nails, and sweat glands. Therefore, understanding the formation and function of surface ectodermal cells is also important in identifying and addressing certain genetic disorders and conditions. In summary, surface ectodermal cells are essential in embryonic development, contributing to the creation of the external physical appearance and the sensory organs of an organism. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "doi:/10.1101/2024.07.02.601324" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000114 ; owl:annotatedTarget "surface ectoderm cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002012 ; owl:annotatedTarget obo:CL_0000547 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:19805084" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002012 ; owl:annotatedTarget "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." . [] a owl:Axiom ; rdfs:label "surface ectodermal cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000114 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000114" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002013 ; owl:annotatedTarget obo:CL_0000549 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:1638021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002013 ; owl:annotatedTarget "A basophilic erythroblast that is GlyA-positive." . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D042783", "PMID:21275341", "http://en.wikipedia.org/wiki/Endothelial_cell", "https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000115 ; owl:annotatedTarget "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002014 ; owl:annotatedTarget obo:CL_0000549 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:19805084" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002014 ; owl:annotatedTarget "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000115 ; owl:annotatedTarget "ZFA:0009065" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002015 ; owl:annotatedTarget obo:CL_0000550 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:19805084" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002015 ; owl:annotatedTarget "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." . [] oboInOwl:hasDbXref "GOC:cvs", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000116 ; owl:annotatedTarget "Pioneer neurons establish a pathway in the developing central nervous system and then undergo programmed cell death once the adult axons, which follow them, have made connections with the target site. Thus, they are a transient cell type involved in axon guidance." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002016 ; owl:annotatedTarget obo:CL_0000550 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:1638021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002016 ; owl:annotatedTarget "A polychromatiic erythroblast that is Gly-A-positive and CD71-low." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000116 ; owl:annotatedTarget "FBbt:00005128" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000116 ; owl:annotatedTarget "ZFA:0009066" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002017 ; owl:annotatedTarget obo:CL_0000552 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:19805084" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002017 ; owl:annotatedTarget "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002018 ; owl:annotatedTarget obo:CL_0000552 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000117 ; owl:annotatedTarget "ZFA:0009067" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:1638021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002018 ; owl:annotatedTarget "An erythroblast that is GlyA-positive and CD71-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002019 ; owl:annotatedTarget obo:CL_0002422 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:18539294" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002019 ; owl:annotatedTarget "A reticulocyte that is Ly76-high and is Kit-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002020 ; owl:annotatedTarget obo:CL_0002422 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:1638021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002020 ; owl:annotatedTarget "A reticulocyte that is GlyA-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002021 ; owl:annotatedTarget obo:CL_0000595 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:20134094" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002021 ; owl:annotatedTarget "An enucleate erythrocyte that is GlyA-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002022 ; owl:annotatedTarget obo:CL_0000595 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:19805084" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002022 ; owl:annotatedTarget "An enucleate erythrocyte that is Lyg-76-high." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002023 ; owl:annotatedTarget obo:CL_0000553 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:15232614" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002023 ; owl:annotatedTarget "A megakaroycotye progenitor cell that is CD34-positive, CD41-positive and CD42-positive on the cell surface." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002024 ; owl:annotatedTarget obo:CL_0000553 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:16951553" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002024 ; owl:annotatedTarget "A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low." . [] oboInOwl:hasDbXref "WikipediaVersioned:Basket_cell&oldid=951703880" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000118 ; owl:annotatedTarget "Basket cells are inhibitory GABAergic interneurons of the brain. In general, dendrites of basket cells are free branching and contain smooth spines. Axons are highly branched. The branched axonal arborizations give rise to basket-like structures that surround the soma of the target cell. Basket cells form axo-somatic synapses, meaning their synapses target somas of other cells." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002025 ; owl:annotatedTarget obo:CL_0000553 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:15232614" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002025 ; owl:annotatedTarget "A megakaryocyte progenitor cell that is CD34-positive, CD41-positive, and CD42-negative." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000118 ; owl:annotatedTarget "ZFA:0009068" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002026 ; owl:annotatedTarget obo:CL_0000556 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:15232614" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002026 ; owl:annotatedTarget "A megakaryocyte progenitor cell that is CD34-negative, CD41-positive and CD42-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002027 ; owl:annotatedTarget obo:CL_0000556 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002027 ; owl:annotatedTarget "A megakaryocyte cell with is CD9-positive and CD41-positive." . [] oboInOwl:hasDbXref "NIFSTD:sao1415726815" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000119 ; owl:annotatedTarget "Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004." . [] oboInOwl:hasDbXref "GOC:ak", "GOC:dsd", "GOC:tfm", "PMCID:PMC1312421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002028 ; owl:annotatedTarget "A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000119 ; owl:annotatedTarget "ZFA:0009069" ; sssom:mapping_justification . [] dc:license ; oboInOwl:hasDbXref "doi:10.1016/j.cnp.2022.11.002" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000119 ; owl:annotatedTarget . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002029 ; owl:annotatedTarget obo:CL_0000831 . [] oboInOwl:hasDbXref "GOC:tfm", "PMCID:PMC1312421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002029 ; owl:annotatedTarget "A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low." . [] dc:license ; oboInOwl:hasDbXref "doi:10.3389/fnins.2020.00293" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000119 ; owl:annotatedTarget . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002030 ; owl:annotatedTarget obo:CL_0000613 . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000120 ; owl:annotatedTarget "A neuron of the vertebrate central nervous system that is small in size. This general class includes small neurons in the granular layer of the cerebellar cortex, cerebral cortex neurons that are not pyramidal cells and small neurons without axons found in the olfactory bulb." . [] oboInOwl:hasDbXref "GOC:tfm", "PMCID:PMC1312421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002030 ; owl:annotatedTarget "A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002031 ; owl:annotatedTarget "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000120 ; owl:annotatedTarget "ZFA:0009070" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19022770", "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002032 ; owl:annotatedTarget "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." . ( ) . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002033 ; owl:annotatedTarget obo:CL_0001008 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:15572596", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002033 ; owl:annotatedTarget "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." . [] oboInOwl:hasDbXref "MESH:D011689", "PMID:12907269", "PMID:14568361", "PMID:31424738", "PMID:33288911", "PMID:38168772" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000121 ; owl:annotatedTarget "An inhibitory neuron and the sole output neuron of the cerebellar cortex, the Purkinje cell's soma is located between the granular and molecular layers of the cerebellum. It is one of the largest neural cells in the mammalian brain, ranging from 50 to 80 micrometres in diameter. Purkinje cells have planar, fan-shaped dendrites that branch extensively with little overlap. This cell type receives synaptic input from parallel fibres, which modulate high-frequency spike activity known as \"simple spikes,\" and climbing fibres, which modulate infrequent calcium spike activity known as \"complex spikes\". Purkinje cells are involved in motor coordination, particularly in correcting movements in progress." . [] oboInOwl:hasDbXref "DOI:10.1007/s12311-018-0985-7", "DOI:10.1038/nrn3886", "DOI:10.7554/eLife.63668", "https://www.ncbi.nlm.nih.gov/books/NBK545154/", "https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/purkinje-cell" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000121 ; owl:annotatedTarget """Purkinje cells, named after the Czech anatomist Jan Evangelista Purkyně who discovered them, are unique inhibitory neurons in the cerebellar cortex. They are a critical part of the vertebrate nervous system as they provide the only signal output from the cortex to the cerebellar nuclei. They are one of the few types of neurons that are large enough to be seen with the naked eye. The most distinct hallmark of Purkinje cells is their elaborate dendritic arbor, which forms a broad and intricately branching structure resembling a tree. These numerous branches each receive excitatory synaptic inputs from more than 100,000 parallel fibers; in addition, a single climbing fiber makes hundreds of synapses to the soma and proximal dendrites. A single long axon forms an inhibitory projection to the cerebellar nuclei. Purkinje cells play key roles in the coordination of fine, voluntary motor movements and balance. As the sole output of all motor coordination in the cerebellar cortex, they serve as a central relay in the cerebro-cerebellar loop. Each Purkinje cell receives two types of synaptic input: one from parallel fibers (which are axons of granule cells), and the other from climbing fibers (originating from the inferior olivary nucleus). The Purkinje cells process and integrate these diverse kinds of input signals to generate output that controls timing and coordination of movements. Purkinje neurons show considerable synaptic plasticity. Throughout life, these cells continue to undergo long-term potentiation and depression at parallel fiber synapses, which cause long-lasting increase or decrease, respectively, of synaptic transmission and have been proposed as mechanisms for motor learning. Purkinje cells are also known to be implicated in a variety of diseases. Their progressive loss is a prime feature in certain types of ataxia, a collective term used to describe conditions characterized by loss of muscular control and coordination. Furthermore, a significant reduction in the density of Purkinje cells has been reported in conditions such as autism and Huntington’s disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002034 ; owl:annotatedTarget obo:CL_0001008 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:15572596", "PMID:17582345" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002034 ; owl:annotatedTarget "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000121 ; owl:annotatedTarget "ZFA:0009071" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002035 ; owl:annotatedTarget obo:CL_0000837 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002035 ; owl:annotatedTarget "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." . [] oboInOwl:hasDbXref "PMID:28821816" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000121 ; owl:annotatedTarget "Purkinje neuron" . [] oboInOwl:hasDbXref "https://doi.org/10.1016/j.proghi.2004.07.002" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000121 ; owl:annotatedTarget "cerebellar Purkinje cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002036 ; owl:annotatedTarget obo:CL_0000837 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002036 ; owl:annotatedTarget "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." . [] oboInOwl:hasDbXref "PMID:38168772" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000121 ; owl:annotatedTarget "PC" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002037 ; owl:annotatedTarget obo:CL_0000793 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:16048545" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002037 ; owl:annotatedTarget "Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive." . [] oboInOwl:hasDbXref "PMID:16048545" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002037 ; owl:annotatedTarget "memory alpha beta IEL" . [] oboInOwl:hasDbXref "PMID:28821816" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000121 ; owl:annotatedTarget "PN" . [] oboInOwl:hasDbXref "PMID:17535929", "PMID:27215193", "PMID:37426070", "https://doi.org/10.1016/j.stem.2023.11.013" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0000121 ; owl:annotatedTarget "Neurodegenerative disorders affecting Purkinje cells disrupt motor functions. Some of the neurodegenerative disorders that causes loss and degeration of Purkinje cells are Spinocerebellar ataxias (SCAs) (Josef P Kapfhammer and Etsuko Shimobayashi 2023), Friedreich's ataxia (FRDA) (Kevin C Kemp et al., 2016), Fetal alcohol syndrome (Laurent Servais et al., 2016), Dandy-Walker malformation (Alexander Atamian et al., 2024)." . [] a owl:Axiom ; rdfs:label "Purkinje cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000121 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000121" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002038 ; owl:annotatedTarget obo:CL_0000492 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19855402", "PMID:20107805", "PMID:22043829" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002038 ; owl:annotatedTarget "A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production." . [] oboInOwl:hasDbXref "PMID:20207847" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002038 ; owl:annotatedTarget "T(FH)" . [] oboInOwl:hasDbXref "PMID:20107805", "PMID:20383172" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002038 ; owl:annotatedTarget "Tfh" . [] oboInOwl:hasDbXref "PMID:22043829" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002038 ; owl:annotatedTarget "follicular B helper T cell" . [] oboInOwl:hasDbXref "PMID:20107805", "PMID:21914188" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002038 ; owl:annotatedTarget "follicular T cell" . [] oboInOwl:hasDbXref "PMID:22552227" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002038 ; owl:annotatedTarget "follicular T-helper cell" . [] oboInOwl:hasDbXref "PMID:22649468" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002038 ; owl:annotatedTarget "follicular helper T cell" . [] oboInOwl:hasDbXref "PMID:22508770" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002038 ; owl:annotatedTarget "follicular helper T-cell" . [] dc:license ; oboInOwl:hasDbXref "doi:10.1016/j.cnp.2022.11.002" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000121 ; owl:annotatedTarget . [] dc:license ; oboInOwl:hasDbXref "doi:10.3389/fnins.2020.00293" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0000121 ; owl:annotatedTarget . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002039 ; owl:annotatedTarget obo:CL_0000914 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:17589542" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002039 ; owl:annotatedTarget "A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002040 ; owl:annotatedTarget obo:CL_0000914 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:17589542", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002040 ; owl:annotatedTarget "A CD24-low, CD44-negative, NK1.1-negative NK T cell." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002041 ; owl:annotatedTarget obo:CL_0000914 . [] oboInOwl:hasDbXref "PMID:17589542" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002041 ; owl:annotatedTarget "A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002042 ; owl:annotatedTarget obo:CL_0000914 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:17589542", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002042 ; owl:annotatedTarget "A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell." . [] oboInOwl:hasDbXref "ISBN:9780123973481" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000122 ; owl:annotatedTarget "A neuron that has dendritic processes radiating from the cell body forming a star-like shape." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000122 ; owl:annotatedTarget "ZFA:0009072" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002043 ; owl:annotatedTarget obo:CL_0000837 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18371405", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002043 ; owl:annotatedTarget "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." . [] oboInOwl:hasDbXref "MESH:D009457" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000125 ; owl:annotatedTarget "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002044 ; owl:annotatedTarget obo:CL_0002028 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002044 ; owl:annotatedTarget "A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative." . [] oboInOwl:hasDbXref "DOI:10.1002/glia.24343", "DOI:10.1038/nn1988", "DOI:10.1101/cshperspect.a020602", "DOI:10.1126/science.aat0473", "DOI:10.3389/fncel.2017.00024" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000125 ; owl:annotatedTarget """Glial cells, also known as neuroglia or simply glia, are non-neuronal cells in the central and peripheral nervous systems that provide support and protection for neurons. They constitute approximately half of the total cells in the human brain and more than half in other parts of the nervous system. Glial cells perform several key functions including, but not limited to, maintaining homeostasis, forming the myelin sheath around the neuron axons, and providing support and nutrition to neurons. These different functions are performed by various glial cell types, including astrocytes, oligodendrocytes, microglia and other specialized types. Astrocytes, for example, are the most abundant glial cells and provide metabolic and nutrient support to neurons, help regulate the extracellular ion and neurotransmitter levels, and play a role in the formation and maintenance of the blood-brain barrier, contributing to the overall homeostasis and functioning of the nervous system. Additionally, astrocytes are involved in synaptic communication and participate in processes such as synaptogenesis and synaptic pruning. Oligodendrocytes in the central nervous system function to insulate neurons by producing a fatty substance known as myelin. The myelin sheath enhances the speed and efficiency of nerve impulse conduction along the axons. Microglia, the immune cells of the central nervous system, protect neurons from pathogens and clear away dead neurons through phagocytosis, a process also known as cellular eating. They also contribute to the regulation of inflammation in response to signals of tissue damage or infection in the central nervous system by releasing cytokines and other signaling molecules that modulate the immune response. Despite their overarching function in the support and protection of neurons, glial cells have also been shown to play significant roles in the pathophysiology of many psychiatric and neurodegenerative diseases, such as Alzheimer’s, Parkinson’s Disease and multiple sclerosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000125 ; owl:annotatedTarget "FBbt:00005144" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002045 ; owl:annotatedTarget obo:CL_0000826 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:12633665", "PMID:17582343", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002045 ; owl:annotatedTarget "A pro-B cell that is CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000125 ; owl:annotatedTarget "ZFA:0009073" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "glial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000125 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000125" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002046 ; owl:annotatedTarget obo:CL_0000826 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "PMID:18432934" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002046 ; owl:annotatedTarget "A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000126 ; owl:annotatedTarget "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002047 ; owl:annotatedTarget obo:CL_0002400 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000126 ; owl:annotatedTarget "ZFA:0009074" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:18432934" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002047 ; owl:annotatedTarget "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative." . [] oboInOwl:hasDbXref "doi:10.1152/physrev.2001.81.2.871" ; oboInOwl:hasSynonymType obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000126 ; owl:annotatedTarget "macroglia" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002048 ; owl:annotatedTarget obo:CL_0000817 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "PMID:18432934" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002048 ; owl:annotatedTarget "A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive." . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "MESH:D001253", "PMID:11746784", "PMID:12162730", "PMID:12898703", "PMID:20942978", "http://en.wikipedia.org/wiki/Astrocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000127 ; owl:annotatedTarget "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000127 ; owl:annotatedTarget "ZFA:0009075" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002049 ; owl:annotatedTarget obo:CL_0002400 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:17582343" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002049 ; owl:annotatedTarget "A precursor B cell that is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000128 ; owl:annotatedTarget obo:CL_0000126 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002050 ; owl:annotatedTarget obo:CL_0000817 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:17582343" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002050 ; owl:annotatedTarget "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive." . [] oboInOwl:hasDbXref "MESH:D009836", "http://en.wikipedia.org/wiki/Oligodendrocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000128 ; owl:annotatedTarget "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002051 ; owl:annotatedTarget obo:CL_0000952 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18432934" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002051 ; owl:annotatedTarget "A pre-BCR positive B cell that is CD38-high." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000128 ; owl:annotatedTarget "ZFA:0009076" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "PMID:8734446" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000128 ; owl:annotatedTarget "OLs" . [] oboInOwl:hasDbXref "GOC:ak", "GOC:dsd", "GOC:tfm", "PMID:17582343", "PMID:18432934", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002052 ; owl:annotatedTarget "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002052 ; owl:annotatedTarget "fraction D pre-B cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002053 ; owl:annotatedTarget obo:CL_0000954 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18432934" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002053 ; owl:annotatedTarget "A small pre-B cell that is CD22-positive and CD38-low." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002054 ; owl:annotatedTarget obo:CL_0000816 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:dsd", "GOC:tfm", "PMID:17582343", "PMID:18432934" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002054 ; owl:annotatedTarget "An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive." . [] oboInOwl:hasDbXref "MESH:D013093" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000020 ; owl:annotatedTarget "An euploid male germ cell of an early stage of spermatogenesis." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002055 ; owl:annotatedTarget obo:CL_0000816 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18432934" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002055 ; owl:annotatedTarget "An immature B cell that is CD38-negative, CD10-low, CD21-low, and CD22-high." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:17582343" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002056 ; owl:annotatedTarget "A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002057 ; owl:annotatedTarget obo:CL_0000860 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "PMID:15615263", "PMID:1706877", "PMID:19689341", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002057 ; owl:annotatedTarget "A classical monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002057 ; owl:annotatedTarget "CD16- monocyte" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002058 ; owl:annotatedTarget obo:CL_0000875 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:8890901" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002058 ; owl:annotatedTarget "A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002059 ; owl:annotatedTarget obo:CL_0000941 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19273629", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002059 ; owl:annotatedTarget "A conventional thymic dendritic cell that is CD8-alpha-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002060 ; owl:annotatedTarget obo:CL_0000864 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20479296", "PMID:2943821" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002060 ; owl:annotatedTarget "A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002061 ; owl:annotatedTarget obo:CL_0000492 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18931678", "PMID:19604299", "PMID:20154671" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002061 ; owl:annotatedTarget "A T-helper cell that is characterized by secreting interleukin 9 and responding to helminth infections. This cell-type can derives from Th2 cells in the presence of TGF-beta and IL-4. Th2 cytokine production is surpressed." . [] oboInOwl:hasDbXref "PMID:18931678" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002061 ; owl:annotatedTarget "Th9" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000020 ; owl:annotatedTarget "FBbt:00004934" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20054144", "PMID:29463737", "http://www.copewithcytokines.de" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002062 ; owl:annotatedTarget "A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange." . [] oboInOwl:hasDbXref "PMID:32491474" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002062 ; owl:annotatedTarget "type 1 pneumocyte" . [] oboInOwl:hasDbXref "PMID:29463737" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002062 ; owl:annotatedTarget "AT1" . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002062 ; owl:annotatedTarget "ATI" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002062 ; owl:annotatedTarget "The marker set AGER can identify the Human cell type pulmonary alveolar type 1 cell in the lung with a confidence of 0.85 (NS-Forest FBeta value)." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM558.BZLS.992" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002062 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0412046911", "PMID:36138472", "PMID:8540632", "http://www.copewithcytokines.de" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002063 ; owl:annotatedTarget "A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants via specialized organelles called alveolar lamellar bodies. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, has a rounded apical surface that projects above the level of the surrounding epithelium, and its free surface is covered by short microvilli." . [] oboInOwl:hasDbXref "PMID:32491474" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002063 ; owl:annotatedTarget "type II pneumocyte" . [] oboInOwl:hasDbXref "PMID:36138472" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002063 ; owl:annotatedTarget "AT2" . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002063 ; owl:annotatedTarget "ATII" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002063 ; owl:annotatedTarget "The marker set SFTPA1 can identify the Human cell type pulmonary alveolar type 2 cell in the lung with a confidence of 0.95 (NS-Forest FBeta value)." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM558.BZLS.992" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002063 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002064 ; owl:annotatedTarget obo:CL_0000622 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "PMID:20395539", "http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002064 ; owl:annotatedTarget "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." . [] oboInOwl:hasDbXref "DOI:10.1016/0165-6147(89)90192-2", "DOI:10.1038/nrgastro.2013.36", "DOI:10.1097/01.mog.0000239863.96833.c0", "https://www.ncbi.nlm.nih.gov/books/NBK54134/" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002064 ; owl:annotatedTarget """Pancreatic acinar cells are the functional units of the exocrine pancreas. These cells are structurally arranged in small clusters - or acini - with a small central lumen, and their primary function is to produce and secrete enzymes that facilitate digestion of proteins, carbohydrates, and fats within the small intestine. Some of the most important digestive enzymes synthesized by the pancreatic acinar cells include amylase, which digests carbohydrates, lipase, which breaks down fats, and several proteases such as trypsin and chymotrypsin which are vital for the digestion of proteins. Importantly, these enzymes are produced as proenzymes or zymogens to avoid autolysis, or the breakdown of the pancreas itself. The release of these enzymes by the pancreatic acinar cells is strictly regulated by hormones and neurochemicals. Cholecystokinin (CCK) released from the enteroendocrine cells in the duodenum cause the release of these enzymes. Moreover, acinar cells also respond to another hormone, secretin, by releasing bicarbonate-rich fluid which helps to neutralize the gastric acid in the duodenum. Dysregulation in the function of pancreatic acinar cells can lead to severe health issues, including pancreatitis, which is characterized by inflammatory damage to the organ due to the premature activation of digestive enzymes. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0002064 ; owl:annotatedTarget "ZFA:0005739" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "pancreatic acinar cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002064 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002064" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM586.MNXV.276" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002064 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-pancreatic-acinus/v1.2/assets/2d-ftu-pancreas-pancreatic-acinus.png" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0412046911", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002066 ; owl:annotatedTarget "A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane." . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002066 ; owl:annotatedTarget "P cell" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0412046911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002067 ; owl:annotatedTarget "An enteroendocrine cell that produces glucagon." . [] oboInOwl:hasDbXref "DOI:10.1016/j.diabres.2018.06.013", "DOI:10.1210/en.2016-1748", "DOI:10.2337/db15-1541", "DOI:10.2337/dbi19-0002", "DOI:10.3389/fphys.2012.00349/full" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002067 ; owl:annotatedTarget """Type A enteroendocrine cells, also known as alpha cells or A cells, are a species of endocrine cells primarily located in the pancreatic islets of Langerhans; they have also been identified within the lining of the stomach. Functionally, these cells are pivotal in glucose metabolism and homeostasis, accounting for about 20% of the total population of cells in the pancreatic islets. The primary role of type A enteroendocrine cells involves the synthesis, storage, and secretion of the peptide hormone glucagon, which is critical in energy regulation throughout the body. In response to a decrease in blood glucose levels, the pancreatic A cells are stimulated to secrete glucagon into the bloodstream. Glucagon acts on its target cells, mainly in the liver, to stimulate glycogenolysis and gluconeogenesis processes, thereby increasing blood glucose levels back to normal. In this way, pancreatic A cells play an integral role in maintaining glucose homeostasis and preventing hypoglycemia. Pancreatic A cells also participate in the local regulation of islet activities as glucagon acts through glucagon receptors on A, B and D type cells within the islets. Recent studies have also shown that Pancreatic A cells play a role in the generation and regeneration of B type cells. Following beta cell injuries pancreatic A cells increase in numbers and produce Glucagon-like peptide-1 (GLP-1), which increases the proliferation and cytoprotection of beta cells. In response to extreme injury of B type cells pancreatic A cells can transform (transdifferentiate) into functioning B type cells. Until recently, glucagon has been considered a pancreas-specific hormone; however, extrapancreatic glucagon has been reported in patients who had undergone complete, and glucagon-positive cells been identified in the human stomach, indicating that Type A enteroendocrine cells are not restricted to the pancreas. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "type A enteroendocrine cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002067 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002067" . [] oboInOwl:hasDbXref "FMA:0412046911", "GOC:tfm", "PMID:19939742" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002068 ; owl:annotatedTarget "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002069 ; owl:annotatedTarget "Mostly cylindrical, resemble Type 1 in their contents and the presence of a kinocilium and stereocilium apically; much greater variation in size, some almost span the entire thickness of the sensory epithelium, while others are smaller than Type 1; receive multiple efferent nerve boutons around their bases as well as afferent endings, which are small expansions rather than chalices." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002070 ; owl:annotatedTarget "Bottle-shaped with narrow neck; broad, rounded basal portion where nucleus is located; stereocilia and a single kinocilium is present apically; receive nerve bouton at their base from an afferent cup-shaped (chalice or calyx) nerve ending." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002071 ; owl:annotatedTarget obo:CL_0002253 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002071 ; owl:annotatedTarget "Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type." . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM294.HJJZ.279" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002071 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/large-intestine-crypt-lieberkuhn/v1.2/assets/2d-ftu-large-intestine-crypt-lieberkuhn.png" . [] oboInOwl:hasDbXref "FMA:67101", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002072 ; owl:annotatedTarget "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002072 ; owl:annotatedTarget "cardiac pacemaker cell" . [] oboInOwl:hasDbXref "FMA:67142", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002073 ; owl:annotatedTarget "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." . [] oboInOwl:hasDbXref "FMA:67111", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002074 ; owl:annotatedTarget "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "PMID:15817800", "PMID:30291131", "PMID:37925434" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002075 ; owl:annotatedTarget "A rare type of columnar epithelial cell that is part of the tracheobronchial epithelium. This cell is characterized by a distinctive tuft of apical microvilli, which extends into the cytoplasm, and a pear-shaped morphology, broad at the base and tapering to a narrow apex. It plays vital roles in chemosensation, producing cytokines like IL-25, and enhancing mucociliary clearance through acetylcholine release to support mucus movement and airway defense." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002075 ; owl:annotatedTarget "The marker set POU2F3, HOMER3, MYB can identify the Human cell type brush cell of tracheobronchial tree in the lung with a confidence of 0.56 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0721601464", "MESH:D017628", "PMID:11517395", "PMID:12430718", "PMID:14561199", "PMID:14612429", "PMID:16177057", "PMID:19461673", "PMID:2089275", "http://en.wikipedia.org/wiki/Microglia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000129 ; owl:annotatedTarget "A transcriptomically distinct central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." . [] oboInOwl:hasDbXref "FMA:69075", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002076 ; owl:annotatedTarget "An epithelial cell derived from endoderm." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0002076 ; owl:annotatedTarget "ZFA:0009383" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FMA:69074", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002077 ; owl:annotatedTarget "An epithelial cell derived from ectoderm." . [] oboInOwl:hasDbXref "DOI:10.1016/j.cell.2019.08.053", "DOI:10.1016/j.conb.2022.102674", "DOI:10.1016/j.tins.2021.11.001", "DOI:10.1038/nri3086", "DOI:10.3389/fnins.2021.742065" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000129 ; owl:annotatedTarget """Microglial cells, sometimes referred to as microglia, are a type of glial cell that primarily exist within the central nervous system (CNS), notably in the brain and the spinal cord. Classified among the resident immune cells, microglial cells represent about 10% of all cells found within the CNS. These cells are derived from progenitor cells in the yolk sac, which differentiates them from other types of glial cells (such as astrocytes and oligodendrocytes) that are derived from neuroectodermal cell lineages. The primary role of microglial cells is to act as the first and main active form of immune defense in the CNS. They express a vast repertoire of pattern recognition receptors, which allow them to sense and eliminate microbes invading the CNS parenchyma. They represent one of the macrophage populations of the CNS and are responsible for phagocytosis (engulfing and destroying cellular waste or pathogens) in the neural environment. Microglial cells are particularly responsive to pathogens and injuries and change their morphology in reaction to inflammation or insult: In the normal state they are characterized by a ramified shape with small processes; in response to stimuli, some microglia mature and change to an amoeboid shape. Beyond their macrophagic activity, they also perform synaptic pruning during brain development, eliminate unnecessarily produced neurons, and facilitate tissue regeneration and repair. they play integral roles in regulating neural development and supporting cell survival and are important for maintaining tissue homeostasis. While their protective role generally benefits the brain, their over-activation can occasionally lead to neuro-inflammatory diseases, underlining the importance of balanced microglial cell functions. They have been extensively studied for their association with neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0002077 ; owl:annotatedTarget "ZFA:0009385" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FMA:69076", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002078 ; owl:annotatedTarget "Epithelial cell derived from mesoderm or mesenchyme." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0002078 ; owl:annotatedTarget "ZFA:0009388" ; sssom:mapping_justification . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000129 ; owl:annotatedTarget "ZFA:0009077" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "FMA:63099", "GOC:tfm", "PMID:14740223" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002079 ; owl:annotatedTarget "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0002079 ; owl:annotatedTarget "ZFA:0009380" ; sssom:mapping_justification . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM992.RCJX.478" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002079 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-intercalated-duct/v1.2/assets/2d-ftu-pancreas-intercalated-duct.png" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM586.MNXV.276" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002079 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-pancreatic-acinus/v1.2/assets/2d-ftu-pancreas-pancreatic-acinus.png" . [] oboInOwl:hasDbXref "CARO:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000003 ; owl:annotatedTarget "OBSOLETE. A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment)." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000020 ; owl:annotatedTarget "FBbt:00004935" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "http://www.copewithcytokines.de/" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000129 ; owl:annotatedTarget "hortega cells" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12142741", "PMID:20018761", "PMID:8185160" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002080 ; owl:annotatedTarget "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0002080 ; owl:annotatedTarget "ZFA:0005740" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "http://www.copewithcytokines.de/" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000129 ; owl:annotatedTarget "microgliocyte" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM992.RCJX.478" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002080 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-intercalated-duct/v1.2/assets/2d-ftu-pancreas-intercalated-duct.png" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM586.MNXV.276" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002080 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-pancreatic-acinus/v1.2/assets/2d-ftu-pancreas-pancreatic-acinus.png" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:7938227", "http://en.wikipedia.org/wiki/Carotid_body" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002081 ; owl:annotatedTarget "This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002082 ; owl:annotatedTarget obo:CL_0000336 . [] oboInOwl:hasDbXref "doi:10.1038/s41598-020-66092-9" ; oboInOwl:hasSynonymType obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000129 ; owl:annotatedTarget "microglia" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002082 ; owl:annotatedTarget "A chromaffin cell of the adrenal medulla that produces epinephrine." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002083 ; owl:annotatedTarget obo:CL_0000336 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:068340007X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002083 ; owl:annotatedTarget "A chromaffin cell of the adrenal medulla that produces norepinephrine." . [] oboInOwl:hasDbXref "GOC:tfm", "http://en.wikipedia.org/wiki/Boettcher_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002084 ; owl:annotatedTarget "A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport." . [] oboInOwl:hasDbXref "PMID:23616747" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0000129 ; owl:annotatedTarget "Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:29351662", "http://neurolex.org/wiki/Category:Tanycyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002085 ; owl:annotatedTarget "A specialized elongated ventricular ependymal cell with one or more processes that extend into the brain parenchyma or associated blood vessels where they contact blood vessel endothelial cells and/or neurons. These cells are found in the ventricles and circumventricular organs of the brain. They are involved in hormonal regulation, gatekeeping molecules between the bloodstream and cerebrospinal fluid, metabolic sensing, and regulating food intake." . [] oboInOwl:hasDbXref "PMID:29351662" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002085 ; owl:annotatedTarget "stretch cell" . [] oboInOwl:hasDbXref "PMID:23649873" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_0002085 ; owl:annotatedTarget "tanycyte-like cell" . [] oboInOwl:hasDbXref "PMID:23649873" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002085 ; owl:annotatedTarget "This class includes cells that are sometimes referred to as tanycyte-like cells, located in circumventricular organs (Langlet et al., 2023) as well as tanycytes located in the ventricles." . [] oboInOwl:hasDbXref "FMA:67968", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002086 ; owl:annotatedTarget "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." . [] a owl:Axiom ; rdfs:label "microglial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000129 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000129" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002087 ; owl:annotatedTarget obo:CL_0000738 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002087 ; owl:annotatedTarget "A leukocyte that lacks granules." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002088 ; owl:annotatedTarget obo:CL_0000710 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:16460275", "PMID:19520112" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002088 ; owl:annotatedTarget "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002088 ; owl:annotatedTarget "intestinal pacemaker cell" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000020 ; owl:annotatedTarget "ZFA:0009007" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "PMID:20200518" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002089 ; owl:annotatedTarget "A group 2 innate lymphoid cell in the mouse capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:068340007X", "http://en.wikipedia.org/wiki/Polar_body" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002090 ; owl:annotatedTarget "One of two small cells formed by the first and second meiotic division of oocytes." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:068340007X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002091 ; owl:annotatedTarget "A small cell formed by the first meiotic division of oocytes." . [] oboInOwl:hasDbXref "EHDAA2:0000541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002091 ; owl:annotatedTarget "first polar body" . [] oboInOwl:hasDbXref "FMA:18650" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002091 ; owl:annotatedTarget "polocytus primarius" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002092 ; owl:annotatedTarget obo:CL_0001035 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002092 ; owl:annotatedTarget "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:068340007X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002093 ; owl:annotatedTarget "A small cell formed by the second meiotic division of oocytes. In mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell." . [] oboInOwl:hasDbXref "FMA:18651" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002093 ; owl:annotatedTarget "polocytus secundarius" . [] oboInOwl:hasDbXref "EHDAA2:0001820" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002093 ; owl:annotatedTarget "second polar body" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002094 ; owl:annotatedTarget "A cell that makes up the loose connective tissue of the ovary." . [] oboInOwl:hasDbXref "PMID:26564856" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000131 ; owl:annotatedTarget "An endothelial cell that lines the blood and lymphatic vessels of the digestive tract. This cell forms the gut–vascular barrier (GVB) through tight junctions and crosstalk with pericytes and enteric glial cells, regulating the passage of nutrients and immune cells while restricting microbial translocation into the bloodstream." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:068340007X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002095 ; owl:annotatedTarget "A cell in the hilum of the ovary that produces androgens." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0781729300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002096 ; owl:annotatedTarget "A specialised myocyte that lies between the sinoatrial node and the atrioventricular node and is involved in the conduction of electrical signals." . [] oboInOwl:hasDbXref "DOI:10.1038/nri2171", "DOI:10.1111/bph.14527", "DOI:10.3390/ijms23073698", "DOI:10.3748/wjg.v17.i5.578", "DOI:full/10.15252/emmm.202114121" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000131 ; owl:annotatedTarget """Gut endothelial cells are a crucial component of the endothelium, a thin layer of single cells that line the interior surface of blood vessels and lymphatic vessels, including those in the digestive system or \"gut\". These cells plays an integral role in various physiological and metabolic functions, actively participating in nutrient absorption, host defense, and vascular homeostasis in the gut. The primary function of gut endothelial cells lies in their ability to control the passage of materials and the transit of white blood cells into and out of the bloodstream. They achieve this through the formation of a semi-permeable barrier, in which permeability is regulated by tight junctions; complex structures that bring the cells together, sealing the space between them. This ensures a controlled, selective passage of nutrients, ions, and water from the bloodstream into the gut and vice versa, helping maintain homeostasis and overall health. Gut endothelial cells also play a significant role in angiogenesis and serve as a critical regulator of the gut immune responses playing a modulative role in gut immune homeostasis and inflammatory responses. In addition, they generate nitric oxide, a potent vasodilator, which helps in maintaining vascular tonus, preventing platelet and leukocyte adhesion, and decreasing smooth muscle proliferation. These multi-faceted roles make gut endothelial cells indispensable for the normal functioning of the gut and overall health. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002097 ; owl:annotatedTarget obo:CL_0002078 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002097 ; owl:annotatedTarget "A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002098 ; owl:annotatedTarget "A cardiac myocyte that is connected to other cardiac myocytes by transverse intercalated discs (GO:0014704) at a regular interval." . [] oboInOwl:hasDbXref "DOI:10.3389/fphys.2013.00102", "https://www.ncbi.nlm.nih.gov/books/NBK572070", "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164530", "https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/cardiac-muscle" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002098 ; owl:annotatedTarget """Cardiac myocytes, also known as cardiac muscle cells, form the majority of the cardiac tissue and are responsible for the contractile function of the heart. These myocytes are columnar-shaped cells with centrally located nuclei, and they exhibit visibly striated cytoplasm due to the organized array of myofibrils, which are composed of filaments of actin and myosin. Cardiac myocytes connect with each other through specialized structures called intercalated discs, facilitating electrical and mechanical continuity and enabling synchronous contraction of the heart. They also possess a high number of mitochondria to meet their high energy demand for continuous heartbeat action. Cardiac myocytes are capable of automaticity, meaning they have the unique ability to spontaneously and rhythmically generate their electrical impulses, a characteristic led by pacemaker cells. The electrical signals initiated and propagated in these cells are responsible for heartbeats. They also respond to the electrical signals transmitted by the autonomic nervous system and chemical signals like hormones. Thus, cardiac myocytes not only participate in maintaining the heart’s function but also play a role in modulating heart rate and strength of contraction in response to the body's changing needs. Consequently, malfunction of these cells leads to serious cardiac diseases such as heart failure and arrhythmias. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "regular cardiac myocyte on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002098 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002098" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000131 ; owl:annotatedTarget "ZFA:0009078" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002099 ; owl:annotatedTarget obo:CL_0002097 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002099 ; owl:annotatedTarget "A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002100 ; owl:annotatedTarget "A regular cardiac myocyte of the interventricular region of the heart." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002101 ; owl:annotatedTarget obo:CL_0000788 . [] a owl:Axiom ; rdfs:label "gut endothelial cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000131 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000131" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002101 ; owl:annotatedTarget "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002102 ; owl:annotatedTarget obo:CL_0000788 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002102 ; owl:annotatedTarget "A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002103 ; owl:annotatedTarget obo:CL_0000981 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002103 ; owl:annotatedTarget "An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002104 ; owl:annotatedTarget obo:CL_0000981 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002104 ; owl:annotatedTarget "An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002105 ; owl:annotatedTarget obo:CL_0000979 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002105 ; owl:annotatedTarget "A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:21976958", "PMID:23284695", "PMID:34741068", "PMID:36769303" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000132 ; owl:annotatedTarget "An hexagonal, flattened, mitochondria-rich endothelial cell that forms a monolayer on the posterior surface of the cornea (the corneal endothelium). Corneal endothelial cells are derived from the neural crest and are responsible for keeping the cornea transparent by maintaining the tissue in a semi-dry state through the action of their ionic pumps and tight junction barrier." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002106 ; owl:annotatedTarget obo:CL_0002105 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002106 ; owl:annotatedTarget "An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000132 ; owl:annotatedTarget "ZFA:0009079" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002107 ; owl:annotatedTarget obo:CL_0002105 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002107 ; owl:annotatedTarget "An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002108 ; owl:annotatedTarget obo:CL_0000979 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:068340007X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000133 ; owl:annotatedTarget "Ectoderm destined to be nervous tissue." . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002108 ; owl:annotatedTarget "A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002109 ; owl:annotatedTarget obo:CL_0002101 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002109 ; owl:annotatedTarget "A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000133 ; owl:annotatedTarget "ZFA:0009080" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002110 ; owl:annotatedTarget "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002111 ; owl:annotatedTarget obo:CL_0000970 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000134 ; owl:annotatedTarget obo:CL_0002320 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002111 ; owl:annotatedTarget "An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002112 ; owl:annotatedTarget obo:CL_0002111 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002112 ; owl:annotatedTarget "A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." . [] oboInOwl:hasDbXref "FB:ma", "GOC:dsd", "PMCID:PMC2613570", "PMID:10102814", "PMID:16923606", "PMID:17986482", "PMID:19960544", "http://en.wikipedia.org/wiki/Mesenchymal_stem_cell", "http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000134 ; owl:annotatedTarget "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002113 ; owl:annotatedTarget "A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002114 ; owl:annotatedTarget obo:CL_0000970 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000134 ; owl:annotatedTarget "ZFA:0009081" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002114 ; owl:annotatedTarget "A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002115 ; owl:annotatedTarget obo:CL_0002114 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002115 ; owl:annotatedTarget "A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." . [] oboInOwl:hasDbXref "PMID:11378515" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_0000134 ; owl:annotatedTarget "marrow stromal cells" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002116 ; owl:annotatedTarget "A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002117 ; owl:annotatedTarget obo:CL_0000972 . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000134 ; owl:annotatedTarget "BMSC" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002117 ; owl:annotatedTarget "A class switched memory B cell that lacks IgG on the cell surface." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002118 ; owl:annotatedTarget obo:CL_0002117 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002118 ; owl:annotatedTarget "A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative." . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000134 ; owl:annotatedTarget "CFU-F" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002119 ; owl:annotatedTarget obo:CL_0002117 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002119 ; owl:annotatedTarget "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative." . [] oboInOwl:hasDbXref "PMID:11378515" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000134 ; owl:annotatedTarget "MSC" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002120 ; owl:annotatedTarget obo:CL_0002118 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002120 ; owl:annotatedTarget "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002121 ; owl:annotatedTarget obo:CL_0002118 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002121 ; owl:annotatedTarget "A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative." . [] oboInOwl:hasDbXref "MESH:D044982" ; oboInOwl:hasSynonymType obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000134 ; owl:annotatedTarget "mesenchymal progenitor cells" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002122 ; owl:annotatedTarget obo:CL_0002119 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002122 ; owl:annotatedTarget "A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative." . [] oboInOwl:hasSynonymType obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000134 ; owl:annotatedTarget "mesenchymal stromal cells" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002123 ; owl:annotatedTarget "A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive." . [] oboInOwl:hasDbXref "MESH:D044982" ; oboInOwl:hasSynonymType obo:OMO_0003004 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000134 ; owl:annotatedTarget "stem cells, mesenchymal" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002124 ; owl:annotatedTarget obo:CL_0000800 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "PMID:19270712" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002124 ; owl:annotatedTarget "A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002125 ; owl:annotatedTarget obo:CL_0000800 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "PMID:19270712" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002125 ; owl:annotatedTarget "A circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative and is capable of IL-17 secretion." . [] oboInOwl:hasDbXref "PMID:21976777" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002125 ; owl:annotatedTarget "gammadelta-17 cells" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002126 ; owl:annotatedTarget obo:CL_0000799 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19270712" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002126 ; owl:annotatedTarget "A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low)." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002127 ; owl:annotatedTarget obo:CL_0000911 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20581831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002127 ; owl:annotatedTarget "A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002128 ; owl:annotatedTarget obo:CL_0000908 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "PMID:19201830", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002128 ; owl:annotatedTarget "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-positive, CCR5-high, CD45RA-negative, and capable of producing IL-17 and some IFNg." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002128 ; owl:annotatedTarget "Tc17 CD8+ T cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002129 ; owl:annotatedTarget "Regular cardiac myocyte of a cardiac atrium." . [] oboInOwl:hasDbXref "DOI:10.1016/j.bbamcr.2015.11.025", "DOI:10.1111/pace.14107", "DOI:10.1172/JCI25417", "https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/cardiac-muscle", "https://www.sciencedirect.com/topics/neuroscience/cardiac-action-potential" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002129 ; owl:annotatedTarget """Regular atrial cardiac myocytes, also known as atrial myocytes, are specialized muscle cells found in the atria – the upper chambers of the heart. They contract and relax during the heart's cycle, modulating the pumping of blood through the atria and into the ventricles. Additionally, endowed with inherent rhythmic electrical activity, atrial myocytes contribute significantly to the initiation and propagation of the heart’s electrical impulses. A distinguishing feature that separates atrial myocytes from other cardiac myocytes is their ability to synthesize and secrete atrial natriuretic peptide (ANP) in response to atrial stretch or dilatation. ANP acts as a potent vasodilator and diuretic, helping to maintain blood pressure and volume homeostasis. The phenomena of atrial stretch or distension, which triggers ANP release, is often in response to excess blood volume entering the heart, providing a mechanism at the cellular level which actively regulates systemic cardiovascular balance. Like all cardiac myocytes, atrial myocytes are embedded in a dense network of connective tissue that provides structural support. These cells are characterized by a single, centrally located nucleus, and overall, have a rod-like appearance with branching ends that connect with adjacent cells to form a continuous, synchronized ensemble. Their cytoplasm is abundant with mitochondria, reflecting the high energy demand associated with constant contraction and relaxation. At the ultrastructural level, atrial myocytes display striations due to the regular arrangement of actin and myosin proteins, which facilitate the contraction process essential for the heart's pump function. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002129 ; owl:annotatedTarget "atrial cardiac muscle cell" . [] a owl:Axiom ; rdfs:label "regular atrial cardiac myocyte on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002129 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002129" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002130 ; owl:annotatedTarget "A cardiac myocyte of the interatrial region of the heart." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002131 ; owl:annotatedTarget "Regular cardiac myocyte of a cardiac ventricle." . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0002131 ; owl:annotatedTarget "ventricular cardiac muscle cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002132 ; owl:annotatedTarget "A stomal cell of the ovary" . [] oboInOwl:hasDbXref "GOC:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002132 ; owl:annotatedTarget "ovarian stromal cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002133 ; owl:annotatedTarget "A stromal cell of the ovarian cortex." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002134 ; owl:annotatedTarget obo:CL_0002132 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002134 ; owl:annotatedTarget "A stromal cell of the ovarian medulla." . [] oboInOwl:hasDbXref "GO:tfm", "PMID:1987287" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002135 ; owl:annotatedTarget "Epidermal cells that do not contain keratin. Cell type is usually associated with moist epidermal tissues." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002136 ; owl:annotatedTarget "A cell in the zona fasciculata that produce glucocorticoids, e.g cortisol." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000135 ; owl:annotatedTarget obo:CL_0000499 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002137 ; owl:annotatedTarget "A cell in the zona reticularis that produce sex hormones." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002138 ; owl:annotatedTarget obo:CL_0002139 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:17846148" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002138 ; owl:annotatedTarget "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions." . [] oboInOwl:hasDbXref "DOI:10.1016/j.it.2022.10.010", "DOI:10.1038/s41577-020-0281-x", "DOI:10.3389/fimmu.2019.00036", "DOI:10.3389/fphys.2020.00509/full", "DOI:10.3892/mco.2017.1356" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002138 ; owl:annotatedTarget """Endothelial cells of lymphatic vessels are specialized type of cells that form the interior lining of the lymphatic system, which primarily comprises the lymph vessels and nodes. These cells play a critical role in creating a barrier between the lymphatic system and the surrounding tissues. They are structurally different from the endothelial cells of the blood vessels due to the presence of anchoring filaments and lack of a continuous basement membrane, and have a unique phenotype marked by the expression of various cell-specific markers such as Prox-1, VEGFR-3, and LYVE-1. A significant function of these endothelial cells is to maintain the fluid balance within the body. They facilitate the uptake of excess interstitial fluid that collects in the body tissues, and ensure its transport back into the bloodstream via the lymphatic vessels. These cells also enable the absorption of fats and fat-soluble vitamins from the digestive system, and their subsequent transport in the form of chyle, a milky fluid, to the blood. Furthermore, endothelial cells of lymphatic vessels play a pivotal role in the body's immune response. They enable the passage of lymphocytes, that are crucial for the body's defense mechanism, from the tissues into the lymph where these cells are activated to fight against foreign bodies and infections. Also, they regulate inflammation reactions by controlling the migration of inflammatory cells, and are thus involved in pathological conditions with an inflammatory component. Lastly, these cells have been noted for their involvement in various disease states related to tissue edema, metastasis, and tumor growth, thus highlighting their importance in both health and disease states. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "ISBN:0412046911", "ISBN:0517223651", "PMID:11641248", "PMID:15010326", "PMID:17607298", "PMID:18222966", "PMID:8790603", "PMID:9551999", "http://en.wikipedia.org/wiki/Fibrocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000135 ; owl:annotatedTarget "An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes." . [] a owl:Axiom ; rdfs:label "endothelial cell of lymphatic vessel on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002138 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002138" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "PMID:12768659" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002139 ; owl:annotatedTarget "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." . [] oboInOwl:hasDbXref "DOI:10.1038/s41569-022-00770-1", "DOI:10.1186/s12872-015-0124-z", "DOI:10.3389/fphys.2022.863265/full", "https://www.sciencedirect.com/topics/medicine-and-dentistry/vascular-endothelial-cell" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002139 ; owl:annotatedTarget """Endothelial cells of the vascular tree, commonly referred to as vascular endothelial cells, line the entire circulatory system, from the heart to the smallest capillaries. These cells have a unique, flattened shape, and are tightly bound together, forming a thin layer known as the endothelium. The endothelium is responsible for maintaining the interior surface of blood vessels, and plays a critical role in ensuring the smooth flow of blood. Vascular endothelial cells act as a semi-permeable membrane, controlling the passage of materials and the transit of white blood cells into and out of the bloodstream. These cells are also involved in blood coagulation. When a blood vessel is damaged, endothelial cells promote clotting to prevent excessive bleeding and facilitate wound healing. Other functions include regulation of blood pressure and blood volume by releasing vasodilators and vasoconstrictors to either widen or constrict blood vessels, accordingly. Furthermore, the endothelial cells are crucial in the formation of new blood vessels, a process known as angiogenesis. This is particularly important in wound healing and the growth of new tissues during development or after injury. In the context of diseases such as cancer, angiogenesis helps facilitate tumor growth by providing nutrients and oxygen. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "endothelial cell of vascular tree on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002139 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002139" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002140 ; owl:annotatedTarget obo:CL_0000317 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:37205445" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002140 ; owl:annotatedTarget "An acinar cell that is part of a skin sebaceous gland. This cell produces and secretes sebum into hair follicles." . [] oboInOwl:hasDbXref "FMA:0517223651", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002141 ; owl:annotatedTarget "A parathyroid chief cell that is actively secreting hormone. Have large Golgi complexes with numerous vesicles and small membrane-bound granules; secretory granules are rare, cytoplasmic glycogen sparse, much of the cytoplasm being occupied by flat sacs of granular endoplasmic reticulum in parallel arrays; in normal humans, inactive chief cells outnumber active chief cells in a ratio of 3-5:1" . [] oboInOwl:hasDbXref "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002142 ; owl:annotatedTarget "A cell pyramidal in shape, with their broad ends facing and forming the greater extent of the lining of the main lumen. Secretes glycoproteins associated with mucus." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002143 ; owl:annotatedTarget "A chief cell that is smaller than light chief cells and has a smaller and darker nucleus and a finely granular cytoplasm with many granules." . [] oboInOwl:hasDbXref "MESH:D017667" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000136 ; owl:annotatedTarget "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002144 ; owl:annotatedTarget "An endothelial cell found in capillaries." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000136 ; owl:annotatedTarget "ZFA:0009082" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:28400610" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002145 ; owl:annotatedTarget "A multi-ciliated epithelial cell located in the trachea and bronchi, characterized by a columnar shape and motile cilia on its apical surface. These cilia facilitate mucociliary clearance by moving mucus and trapped particles toward the pharynx." . [] oboInOwl:hasDbXref "DOI:10.1101/cshperspect.a028241", "DOI:10.1146/annurev-physiol-021014-071931", "DOI:10.1152/ajplung.00329.2019", "DOI:10.1159/000196486" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002145 ; owl:annotatedTarget """Ciliated columnar cells of the tracheobronchial tree compose the inner lining of the tracheobronchial tree, the system of airways consisting of trachea, bronchi and bronchioles that allow passage of air into the lungs, where gas exchange occurs. A defining feature of these endo-epithelial cells are the tiny hair-like structures covering their surface, known as cilia. The nucleus is located at the base of the cell, and the area above it is rich in mitochondria and well-developed endoplasmic reticulum, both crucial for the energy-intensive process of cilia operation. The primary function of these ciliated cells is to keep the respiratory tract clean via mucociliary clearance or the respiratory escalator. These cells create a two-layered 'coat': The lower \"sol\" layer is watery where the cilia can beat in coordinated waves, and the upper \"gel\" layer is thick and sticky, trapping inhaled particles, such as dust, bacteria, viruses, and other potentially harmful substances. This rhythmical beating of the cilia then moves the mucus and trapped particles upwards and out of the respiratory tract, which is then either coughed out or swallowed. Damage or dysfunction of these ciliated cells, as seen in diseases such as primary ciliary dyskinesia, cystic fibrosis, or chronic bronchitis, may lead to reduced or ineffective mucociliary clearance and an increased susceptibility to respiratory infections. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002145 ; owl:annotatedTarget "The marker set C1orf194, MS4A8 can identify the Human cell type multiciliated columnar cell of tracheobronchial tree in the lung with a confidence of 0.86 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref , "PMID:25386990" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002145 ; owl:annotatedTarget "These cells possess numerous cilia on their surface, typically ranging from 200 to 300 per cell. The cilia vary in length, measuring between 6 to 7 μm in the upper airways (trachea) and becoming shorter, around 4 μm, in the smaller airways (terminal bronchioles). These cells form a two-layered 'coat' in the airway: the lower 'sol' layer is watery, allowing the cilia to beat in coordinated waves, while the upper 'gel' layer is thick and sticky, trapping inhaled particles." . [] a owl:Axiom ; rdfs:label "multiciliated columnar cell of tracheobronchial tree on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002145 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002145" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002146 ; owl:annotatedTarget "A sweat producing cell of eccrine sweat glands. Pyramidal in shape, with its base resting on the basal lamina or myoepitheliocytes, and its microvillus-covered apical plasma membrane line up the intercellular canaliculi. Cell is not stained by hematoxylin or eosin." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002147 ; owl:annotatedTarget "A chief cell of parathyroid glands that does not stain with hematoxylin or eosin. This cell is larger, has a larger nucleus and fewer secretory granules than dark chief cells." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:36267574" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002148 ; owl:annotatedTarget "A cell found within the dental pulp." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:11331626", "PMID:16960017", "PMID:21698266" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002149 ; owl:annotatedTarget "An epithelial cell of the uterus. This cell has a mesodermal origin." . [] oboInOwl:hasDbXref "MESH:D015622", "PMID:12673090" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002150 ; owl:annotatedTarget "Epithelioid macrophage is an activated macrophage that resembles an epithelial cell with finely granular, pale eosinophilic cytoplasm and central, ovoid nucleus (oval or elongate). This cell type is able to merge into one another to form aggregates. The presence of such aggregates may characterize some pathologic conditions, mainly granulomatous inflammation." . [] oboInOwl:hasDbXref "MESH:D015622", "PMID:12673090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002150 ; owl:annotatedTarget "epithelioid histocyte" . [] oboInOwl:hasDbXref "ISBN:0412046911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002151 ; owl:annotatedTarget "A promyelocyte that is considerably smaller, with more condensed chromatin, and nucleoli are no longer conspicuous." . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D010011" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000137 ; owl:annotatedTarget "A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544", "doi:/10.1016/j.autneu.2015.04.008" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002152 ; owl:annotatedTarget "A simple columnar epithelial cell located in the endocervix." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:068340007X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002153 ; owl:annotatedTarget "The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus." . [] oboInOwl:hasDbXref "FMA:0412046911", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002154 ; owl:annotatedTarget "A promyelocyte with a nucleus that is indented and contains more marginated heterochromatin compared to its precursor cell (myeloblast); cytoplasm is deeply basophilic and contains numerous mitochondria and meandering cysternae of endoplasmic reticulum; largest of the granulocyte lineages." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002155 ; owl:annotatedTarget "A crenated erythrocyte with 30+ crenations, bumps or spurs that are the result of damage due to age or disease." . [] oboInOwl:hasDbXref "FMA:0618947256", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002157 ; owl:annotatedTarget "A cell type that makes up the highly vascular membrane lining the marrow cavity of long bones." . [] oboInOwl:hasDbXref "DOI:10.1038/leu.2010.214", "DOI:10.1126/science.75570", "DOI:10.1182/blood-2004-06-2480", "DOI:10.1182/blood-2009-08-239194", "https://www.sciencedirect.com/topics/engineering/endosteum" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002157 ; owl:annotatedTarget """Endosteal cells, also known as osteogenic cells, are a specialized type of cell that resides in the endosteum of the bone marrow cavity. The endosteum is a thin vascular membrane of connective tissue that lines the inner surface of the bony tissue that forms the medullary cavity of long bones. This specific location assigns endosteal cells critical roles in the bone maintenance and regeneration process as they actively participate in bone remodeling, a process that involves both the formation and resorption of bone tissue. Endosteal cells function by regulating the activity of both osteoblasts and osteoclasts. Osteoblasts are cells that deposit new bone, and osteoclasts are responsible for bone resorption, a process important for the maintenance, repair, and remodelling of bones. When new bone tissue is required, such as in instances of bone fractures or increased mechanical stress, endosteal cells differentiate into osteoblasts to facilitate the bone formation process. Conversely, when bone resorption is necessary, these cells are known to release signals that lead to the recruitment and activation of osteoclasts. In addition to this, endosteal cells play a significant role in hematopoiesis, which is the formation of blood cellular components. They function in this process by providing a niche for hematopoietic stem cells, serving to support their maintenance and differentiation. Understanding the functionality of endosteal cells is important in the field of regenerative medicine and stem cell therapy, especially in diseases affecting bone remodeling and hematopoiesis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "endosteal cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002157 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002157" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000137 ; owl:annotatedTarget "ZFA:0009083" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:5686391" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002158 ; owl:annotatedTarget "Epithelial cell found on the external side of the tympanic membrane" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002159 ; owl:annotatedTarget "Epithelial cells derived from general body ectoderm and ectoderm placodes." . [] oboInOwl:hasDbXref "PMID:5686391" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002160 ; owl:annotatedTarget "A cell type found in the basal epithelial layer on the external side of the tympanic membrane. Cell type is flattened with intracellular spaces of variable dimensions." . [] oboInOwl:hasDbXref "PMID:5686391" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002161 ; owl:annotatedTarget "A cell type found on the superficial layer of the external side of the tympanic membrane. This cell-type lacks a nucleus." . [] oboInOwl:hasDbXref "FMA:5686391", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002162 ; owl:annotatedTarget "An extremely flattened cell type found on the inner side of the tympanic membrane. The surface of this cell type carries sparse pleomorphic microvilli that are more common near the junctional zones." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002163 ; owl:annotatedTarget "A rod-shpaed cell that forms a single row adjacent to and supporting the inner hair cells." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002164 ; owl:annotatedTarget "A rod-shaped cell found in 3 or 4 rows that lie adjacent to and support the outer hair cells." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002165 ; owl:annotatedTarget "A supporting cell that is attached to the basement membrane and forms rows that support the hair cells." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002166 ; owl:annotatedTarget obo:CL_0002159 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "ISBN:0815129521" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002166 ; owl:annotatedTarget "An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:7143026" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002167 ; owl:annotatedTarget "A specialized cell involved in sensory perception of smell." . [] oboInOwl:hasDbXref "FMA:0412046911", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002168 ; owl:annotatedTarget "A border cell is a slender columnar cell on the medial portion of the basilar membrane." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002169 ; owl:annotatedTarget obo:CL_0002167 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:7143026" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002169 ; owl:annotatedTarget "An epithelial cell located on the basal lamina of the olfactory epithelium." . [] oboInOwl:hasDbXref "GO_REF:0000034", "MESH:D019902" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000138 ; owl:annotatedTarget "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12014572" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002170 ; owl:annotatedTarget "A keratinized cell located in the hard palate or gingiva." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:17468753" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002171 ; owl:annotatedTarget "A rounded or elliptical epithelial cell, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles; form a distinct basal zone spaced slightly from the basal surface of the epithelium." . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0004482", "PMID:2111803" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002172 ; owl:annotatedTarget "A long, spindle-shaped supporting cells arranged in parallel rows that secretes components of the tectorial membrane and potassium ions into the endolymph." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000138 ; owl:annotatedTarget "ZFA:0009084" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002173 ; owl:annotatedTarget obo:CL_1000618 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0412046911", "http:/www.copewithcytokines.de/cope.cgi?key=Lacis%20cells" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002173 ; owl:annotatedTarget "A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002174 ; owl:annotatedTarget "A cell within the follicle of an ovary." . [] oboInOwl:source ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:CL_0002174 ; owl:annotatedTarget obo:NCBITaxon_50557 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002175 ; owl:annotatedTarget "A cell within the primary follicle of the ovary." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002176 ; owl:annotatedTarget "A cell of a secondary follicile within the ovary." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002177 ; owl:annotatedTarget obo:CL_0000642 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002177 ; owl:annotatedTarget "A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002178 ; owl:annotatedTarget obo:CL_0002251 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002178 ; owl:annotatedTarget "An epithelial cell found in the lining of the stomach." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "Wikipedia:Foveolar_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002179 ; owl:annotatedTarget "A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002180 ; owl:annotatedTarget "An epithelial cell of the stomach. This cell produces mucous." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002181 ; owl:annotatedTarget "A columnar epithelial mucous secreting cell located in the neck of the gastric glands. These cells have numerous apical secretory vesicles containing mucins and a basally displaced nucleus. The mucous they secrete is distinct histochemically from that of the surface mucous cells of stomach." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002182 ; owl:annotatedTarget "OBSOLETE. A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall." . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000140 ; owl:annotatedTarget "Skeletogenic cell that secretes dentine matrix, is derived from odontogenic papilla. Embedded in dentine tissue, and is the transformation of a non-terminally differentiated odontoblast cell." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002183 ; owl:annotatedTarget obo:CL_0000048 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002183 ; owl:annotatedTarget "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:0517223651", "PMID:11891623" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002184 ; owl:annotatedTarget "A flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells; lie in contact with the basal lamina of olfactory epithelium." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000140 ; owl:annotatedTarget "ZFA:0009086" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "PMID:16824012", "PMID:32187560", "WIKIPEDIA:Basal_cell", "doi:/10.1073/pnas.1734203100" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002187 ; owl:annotatedTarget "A mitotically active, columnar-shaped keratinocyte located in the stratum basale of the epidermis and attached to the basement membrane. This cell exhibits heterogeneity, encompassing stem and progenitor subpopulations with distinct molecular and proliferative characteristics (Haensel et al., 2020), and serves as the primary source of new keratinocytes for epidermal renewal, homeostasis, and regeneration." . [] oboInOwl:hasDbXref "PMID:32187560" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002187 ; owl:annotatedTarget "epidermal basal cell" . [] oboInOwl:hasDbXref "PMID:7058342" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002187 ; owl:annotatedTarget "epidermal basal keratinocyte" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:15840009" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002188 ; owl:annotatedTarget "An endothelial cell that is part of the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate." . [] oboInOwl:hasDbXref "PMID:18480313", "PMID:19129259", "PMID:33123011" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002188 ; owl:annotatedTarget "Glomerular endothelial cells have 60-80 nm fenestrations typically lacking diaphragms in adults but present during embryonic development. Some studies found diaphragms in 2-6% of mature rat glomerular capillaries. Their presence may depend on fixation techniques, developmental stage, or dynamic cell changes. Additionally, these cells help maintain the structural integrity of glomerular capillaries through interactions with the basement membrane and podocytes." . [] oboInOwl:hasDbXref "ISBN:1416031855", "PMID:29262154", "PMID:30355494", "PMID:30725734", "PMID:32843640", "WIKIPEDIA:Stratum_granulosum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002189 ; owl:annotatedTarget "A keratinocyte located in the stratum granulosum of the epidermis, characterized by the presence of keratohyalin granules containing filaggrin—which aggregate keratin filament —and by lamellar granules that secrete lipids and enzymes essential for forming the skin’s waterproof barrier. As these cells progress toward the surface, they adopt a flattened morphology and initiate keratinization to become corneocyte and form the protective stratum corneum. In human epidermis, granular keratinocytes are transcriptomically distinguished by high expression of differentiation markers such as DSC1, KRT2, IVL, and TGM3 (Wang et al., 2020), and LOR, FLG, and SPINK5 (Cheng et al., 2018)." . [] oboInOwl:hasDbXref "PMID:32843640" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002189 ; owl:annotatedTarget "granular keratinocyte" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002190 ; owl:annotatedTarget "A flat keratinocyte immediately below the cornified layer." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002191 ; owl:annotatedTarget obo:CL_0000839 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002191 ; owl:annotatedTarget "A cell involved in the formation of a granulocyte." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721601464", "http://en.wikipedia.org/wiki/Metamyelocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002192 ; owl:annotatedTarget "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0323052908", "http://en.wikipedia.org/wiki/Myelocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002193 ; owl:annotatedTarget "A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses." . [] oboInOwl:hasDbXref "ISBN:0781733901" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000141 ; owl:annotatedTarget "An osteocytelike cell with numerous processes, trapped in a lacuna in the cement of the tooth." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002194 ; owl:annotatedTarget obo:CL_0000839 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002194 ; owl:annotatedTarget "A cell involved in the formation of a monocyte (monopoiesis)." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000141 ; owl:annotatedTarget "ZFA:0009087" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002195 ; owl:annotatedTarget obo:CL_0000048 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:26798363" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002195 ; owl:annotatedTarget "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)." . [] oboInOwl:hasDbXref "PMID:18442648" ; oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002195 ; owl:annotatedTarget "HpSC" . [] oboInOwl:hasDbXref "PMID:17901986" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002196 ; owl:annotatedTarget "A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratio that can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:RO_0004050 ; owl:annotatedSource obo:CL_0002196 ; owl:annotatedTarget "Liver progenitor cells have been variously named in rodent and human studies as oval cells, hepatic progenitor cells, liver stem cells, ductular reactions, or atypical ductular cells. They were first described as oval cells in rats due to their large nuclear-to-cytoplasm ratio and oval-shaped nuclei. On the difference between 'hepatic liver stem cells' (HLSC) and 'oval cells': \"... unlike a well-known hepatic progenitor cell population, known as oval cells in rodents, HLSCs do not express CK-7, CK-19, c-kit, CD133 and alpha-smooth muscle actin (α-SMA) (Gaudio et al., 2009)\"." . [] terms:contributor ; oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002196 ; owl:annotatedTarget "hepatic progenitor cell" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002196 ; owl:annotatedTarget "liver progenitor cell" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM889.CJPK.447" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002196 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19073178" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000142 ; owl:annotatedTarget "A cell occurring in the peripheral part of the vitreous body of the eye that may be responsible for production of hyaluronic acid and collagen." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002197 ; owl:annotatedTarget "A parathyroid chief cell that is not actively secreting hormone. Contains small Golgi complexes with only a few grouped vesicles and membrane-bound secretory granules; glycogen and many lipofuscin granules abound but sacs of granular endoplasmic reticulum are rare and dispersed. In normal humans, inactive chief cells out number active chief cells in a ratio of 3-5:1." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544", "PMID:20013317" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002198 ; owl:annotatedTarget "A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands." . [] oboInOwl:hasDbXref "PMID:20013317" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002199 ; owl:annotatedTarget "An oncocyte located in the parathyroid gland." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20013317" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002200 ; owl:annotatedTarget "An oncocyte located in the thyroid." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:11781354", "PMID:25632105" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002201 ; owl:annotatedTarget "A renal intercalated cell that secretes base and reabsorbs acid in the distal segments of the kidney tubule to maintain acid/base balance." . [] oboInOwl:hasDbXref "PMID:25632105" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002201 ; owl:annotatedTarget "type B intercalated cell" . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000144 ; owl:annotatedTarget "OBSOLETE: A classification of cells by their primary end goal or behavior." . [] oboInOwl:hasDbXref "PMID:25632105" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002201 ; owl:annotatedTarget "type B-IC" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002202 ; owl:annotatedTarget "An epithelial cell of the tracheobronchial tree." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:35271673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002203 ; owl:annotatedTarget "A tuft cell that is part of the epithelium of large intestine." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002203 ; owl:annotatedTarget "brush cell of large intestine" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002203 ; owl:annotatedTarget "tuft cell of epithelium of large intestine" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "PMID:15817800", "PMID:30379593", "PMID:36704202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002204 ; owl:annotatedTarget "An epithelial cell found in various organs, including the gastrointestinal and respiratory tracts, characterized by a tuft of 120-140 blunt microvilli on its apical surface. This cell exhibits diverse functions depending on its location, which includes chemosensation, initiation of immune responses, contribution to mucociliary clearance, and defense against parasites." . [] oboInOwl:hasDbXref "DOI:10.1007/978-3-211-99390-3_83", "DOI:10.1038/nature16161", "DOI:10.1111/j.1469-7580.2005.00403.x", "DOI:10.3389/fphys.2015.00087", "DOI:10.5114/ceji.2022.124416" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002204 ; owl:annotatedTarget """Brush cells, also referred to as tuft cells or multivesicular cells, are a specialized type of epithelial cell mainly noted for their characteristic 'brush border' composed of microvilli. These cells reside in the epithelial lining of tissue organs such as the respiratory tract, gastrointestinal tract, and the bile ducts. The name derives from their distinct appearance under the microscope, which resembles a brush due to the dense layer of microvilli protruding into the lumen. A key function of brush cells is chemosensation: They express a variety of signaling molecules and receptors that enable them to detect specific chemical stimuli in the environment and act as sensory transducers. Many of these receptors are responsive to luminal content, which makes brush cells vital for regulating and coordinating appropriate physiological responses to changes in these substances. Recent research has also elucidated an important role for these cells in immunity. Intestinal brush cells have been found to be the source of a cytokine called interleukin-25, which can initiate type 2 immune responses during parasitic infections. This immune function, along with the chemosensing abilities, signifies that brush cells could serve crucial roles in health and disease, although much research is still required to fully elucidate their myriad roles in physiology and pathology. Overall, brush cells are a versatile cell type, whose distinct morphology and functional capabilities allow them to perform a unique set of functions within the body. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:hasDbXref "PMID:36704202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002204 ; owl:annotatedTarget "brush cell" . [] oboInOwl:hasDbXref "PMID:36704202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002204 ; owl:annotatedTarget "caveolated cell" . [] oboInOwl:hasDbXref "PMID:36704202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002204 ; owl:annotatedTarget "fibrillovesicular cell" . [] oboInOwl:hasDbXref "PMID:32307399" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002204 ; owl:annotatedTarget "multivesicular cell" . [] oboInOwl:hasDbXref "PMID:36704202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002204 ; owl:annotatedTarget "peculiar cell" . [] a owl:Axiom ; rdfs:label "tuft cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002204 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002204" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002205 ; owl:annotatedTarget "A brush cell found in the epithelium of lobular bronchiole." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002206 ; owl:annotatedTarget "A brush cell of the epithelium in the terminal bronchiole." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002207 ; owl:annotatedTarget obo:CL_0000307 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002207 ; owl:annotatedTarget obo:CL_0002075 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002207 ; owl:annotatedTarget "Brush cell of the epithelium in the trachea." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002208 ; owl:annotatedTarget "A brush cell found in the epithelium of bronchus." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002209 ; owl:annotatedTarget "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002210 ; owl:annotatedTarget "A slow muscle cell that contains high levels of myoglobin and oxygen storing proteins giving the cell a red appearance." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002211 ; owl:annotatedTarget "A slow muscle cell that has large amounts of myoglobin, stores energy as triglycerides, generates ATP by the oxidative method and is resistant to fatigue." . [] oboInOwl:hasDbXref "MESH:D018657" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002211 ; owl:annotatedTarget "slow twitch muscle fiber" . [] oboInOwl:hasDbXref "MESH:D018657" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002211 ; owl:annotatedTarget "slow-twitch muscle fiber" . [] oboInOwl:hasDbXref "MESH:D018657" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002211 ; owl:annotatedTarget "intermediate muscle fiber" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002212 ; owl:annotatedTarget "A fast muscle fiber cell that stores energy in the form of glycogen and creatine phosphate." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002213 ; owl:annotatedTarget "A muscle cell with low content of myoglobin and other oxygen storing proteins. This muscle cell has a white appearance." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000021 ; owl:annotatedTarget obo:CL_0000586 . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000145 ; owl:annotatedTarget "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002214 ; owl:annotatedTarget "A type II muscle cell that contains large amounts of myoglobin, has many mitochondria and very many blood capillaries. Type II A cells are red, have a very high capacity for generating ATP by oxidative metabolic processes, split ATP at a very rapid rate, have a fast contraction velocity and are resistant to fatigue." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "http://en.wikipedia.org/wiki/Skeletal_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002215 ; owl:annotatedTarget "A type II muscle cell that contains a low content of myoglobin, relatively few mitochondria, relatively few blood capillaries and large amounts of glycogen. Type II B fibres are white, geared to generate ATP by anaerobic metabolic processes, not able to supply skeletal muscle fibres continuously with sufficient ATP, fatigue easily, split ATP at a fast rate and have a fast contraction velocity." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002216 ; owl:annotatedTarget "An intermediate muscle cell that has characteristics of both fast and slow muscle cells." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002217 ; owl:annotatedTarget "A trophoblast that leaves the placenta and invades the endometrium and myometrium. This cell type is crucial in increasing blood flow to the fetus." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002218 ; owl:annotatedTarget "A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002219 ; owl:annotatedTarget "A trophoblast found at the junction of the placenta. This cell type makes a unique fibronectin-trophouteronectin junction that helps mediate attachment of the placenta to the uterus. This cell type is also found junction of the chorion layer of the external membranes and the decidua." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002220 ; owl:annotatedTarget "A cell located between the pinealocytes." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:11694559" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002221 ; owl:annotatedTarget "A squamous cell that has keratin in the esophagus." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002222 ; owl:annotatedTarget "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000145 ; owl:annotatedTarget "ZFA:0009088" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002223 ; owl:annotatedTarget "A cell of the transparent layer of simple cuboidal epithelium over the anterior surface of the lens; transform into lens fiber(s)." . [] oboInOwl:hasDbXref "DOI:10.1016/j.biocel.2007.10.034", "DOI:10.1111/aos.14600", "DOI:10.1155/2021/9951032" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002223 ; owl:annotatedTarget """The anterior lens cells, also known as lens epithelial cells, are an integral part of the eye's structure and play a critical role in the organ's physiological functioning. They are situated in the anterior portion of the lens, precisely in the lens capsule, and stretch over the lens' frontal surface. The primary function of anterior lens cells is to facilitate eye accommodation by controlling the shape and thickness of the eye lens. The cells are involved in continuous proliferation, migration, and differentiation into lens fiber cells, helping to maintain lens growth and transparency. Anterior lens cells have a prolonged life span and reveal an extraordinary ability to function indefinitely, a characteristic that is critical for maintaining lens transparency. Damage or disturbance to the anterior lens cells can give rise to lens opacity, eventually leading to cataracts, which is a common cause of vision loss. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "anterior lens cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002223 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002223" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002224 ; owl:annotatedTarget obo:CL_0000075 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544", "http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002224 ; owl:annotatedTarget "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." . [] oboInOwl:hasSynonymType obo:OMO_0003000 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000145 ; owl:annotatedTarget "APC" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002225 ; owl:annotatedTarget "A lens fiber cell that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded." . [] oboInOwl:hasDbXref "DOI:10.1016/B978-1-4377-1926-0.10005-0", "DOI:10.1016/j.biocel.2007.10.034", "DOI:10.1098/rstb.2010.0324", "DOI:10.1136/bmjophth-2020-000459", "https://www.sciencedirect.com/topics/immunology-and-microbiology/lens-fiber" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002225 ; owl:annotatedTarget """Secondary lens fibers are a specialized type of elongated cells located within the structure of the eye's lens. They play an essential role in vision by enabling light transmission and focus on the retina, which allows for clear, distinct vision. These cells are characterized by their lack of nuclei and organelles, their orderly alignment, and their high protein content, particularly crystallins. Lens fibers are differentiated from equatorial epithelial cells of the lens in a process that involves cell elongation, denucleation and tight packing, which serve to reduce light scattering occurrences in the eye. This differentiation accelerates substantially after birth in comparison to during embryogenesis and continues throughout life, contributing to the growth of the eye lens. Secondary lens fibers are specifically those cells that are newly differentiated and cover the old lens fiber core. This process also leads to the removal of light-obstructing cellular components, mainly nuclei and organelles, making these fibers transparent and ideal for their function. The fibers carry out their primary function of light refraction via a high concentration of specialized proteins known as crystallins, which form a gradient of refractive index together with the cytoplasm. This index manipulation facilitates precise light focus onto the retina. Secondary lens fibers also contribute to the lens's shape and biomechanical properties through intercellular interactions, particularly at the sutures where the ends of the fibers meet. Any disruption to secondary lens fibers can lead to vision problems, including cataracts, which is the clouding of the lens resulting from the aggregation of crystallin proteins. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "secondary lens fiber on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002225 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002225" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002226 ; owl:annotatedTarget "A secondary lens fiber cell that lacks a nucleus." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002227 ; owl:annotatedTarget "A secondary fiber cell that contains a nucleus." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:10711704" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002228 ; owl:annotatedTarget "An elongating cell that rapidly obliterates the lumen of the lens vesicle. Subsequently, differentiation of this cell type at the lens equator leads to the formation of secondary fiber cells that come to overlie the primary fibers." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002229 ; owl:annotatedTarget "A chief cell that is bigger than dark chief cells and has a larger and lighter nucleus and a cytoplasm with few granules." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000146 ; owl:annotatedTarget "ZFA:0009089" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002231 ; owl:annotatedTarget obo:CL_0002076 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002231 ; owl:annotatedTarget "An epithelial cell of the prostate." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000147 ; owl:annotatedTarget "A pigment cell is a cell that contains pigment granules." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002232 ; owl:annotatedTarget obo:CL_0000072 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002232 ; owl:annotatedTarget "An epithelial cell of prostatic duct." . [] oboInOwl:hasDbXref "FMA:74224" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002232 ; owl:annotatedTarget "ductal epithelial cell of prostate" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000147 ; owl:annotatedTarget "ZFA:0009090" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002233 ; owl:annotatedTarget obo:CL_0002231 . [] oboInOwl:hasDbXref "GOC:tfm", "PMCID:PMC2673349" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002233 ; owl:annotatedTarget "An epithelial cell of the prostatic acinus." . [] oboInOwl:hasDbXref "FMA:74223" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002233 ; owl:annotatedTarget "acinar epithelial cell of prostate" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002234 ; owl:annotatedTarget "A cell of the basal layer of the epithelium in the prostatic acinus." . [] oboInOwl:hasDbXref "FMA:74265" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002234 ; owl:annotatedTarget "basal epithelial cell of prostatic acinus" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002235 ; owl:annotatedTarget "A cell of the luminal layer of the epithelium in the prostatic acinus." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:15226377" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002236 ; owl:annotatedTarget "A cell that constitutes the basal layer of epithelium in the prostatic duct." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002237 ; owl:annotatedTarget "A cell that constitutes the luminal layer of epithelium of prostatic duct." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002238 ; owl:annotatedTarget "A primordial germ cell that is destined to become a male germ cell." . [] oboInOwl:hasDbXref "VHOG:0000662" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002238 ; owl:annotatedTarget "testis primordial germ cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002239 ; owl:annotatedTarget "A primordial cell from which an oocyte (ovum) ultimately is developed." . [] oboInOwl:hasDbXref "VHOG:0000661" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002239 ; owl:annotatedTarget "ovary primordial germ cell" . [] oboInOwl:hasDbXref "FMA:84772" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002239 ; owl:annotatedTarget "ovigerm" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002240 ; owl:annotatedTarget "A fibroblast in the bone marrow." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002241 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002241 ; owl:annotatedTarget "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." . [] oboInOwl:hasDbXref "https://doi.org/10.5281/zenodo.11165918" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002241 ; owl:annotatedTarget "The marker set DPT, APOD can identify the Human cell type pulmonary interstitial fibroblast in the lung with a confidence of 0.58 (NS-Forest FBeta value)." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:11023867", "PMID:20454446" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000021 ; owl:annotatedTarget "Female germ cell is a germ cell that supports female gamete production." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002242 ; owl:annotatedTarget "A cell containing at least one nucleus." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002243 ; owl:annotatedTarget obo:CL_0000358 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544", "ISBN:0721694128" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002243 ; owl:annotatedTarget "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." . [] oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK532252/", "https://www.ncbi.nlm.nih.gov/books/NBK537180/", "https://www.sciencedirect.com/topics/neuroscience/iris-dilator-muscle", "https://www.sciencedirect.com/topics/neuroscience/iris-sphincter-muscle" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002243 ; owl:annotatedTarget """The smooth muscle cell of sphincter of pupil is a specialized cell type typically found within the eye, more specifically within the sphincter muscle of the iris. These cells can constrict and dilate in response to light signals, tightly regulating the amount of light reaching the retina. Contraction narrows the pupil in bright conditions (pupillary constriction), protecting the retina from excessive light. In low light, relaxation allows dilation (pupillary dilation), enhancing visual perception in dim conditions. These cells are also innervated by parasympathetic fibers from the oculomotor nerve. Light signals to the Edinger-Westphal nucleus stimulate the release of acetylcholine, contracting the cells. On the contrary, sympathetic stimulation induces relaxation. This precise control plays a crucial role in optimizing visual function, highlighting their essential role in vision biology. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "smooth muscle cell of sphincter of pupil on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002243 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002243" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:32644501", "doi:/10.1016/j.autneu.2015.04.008", "http://www.bu.edu/histology/p/19404loa.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002244 ; owl:annotatedTarget "A stratified squamous epithelial cell located in the ectocervix." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:068340007X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002245 ; owl:annotatedTarget "OBSOLETE: A lymphocyte that lacks T or B cell surface markers." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002246 ; owl:annotatedTarget obo:CL_0000037 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002246 ; owl:annotatedTarget "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002247 ; owl:annotatedTarget "A tissue macrophage that is in the pleural space." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19343304" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002248 ; owl:annotatedTarget "A pluripotent stem cell has the ability to form cells from all three germ layers (ectoderm, mesoderm, and endoderm). However, unlike totipotent stem cells, they cell can not generate all the cells of the whole organism such as placenta." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:16938308" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002249 ; owl:annotatedTarget "A stem cell that can differentiate into a cardiac myocyte." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002250 ; owl:annotatedTarget "A stem cell located in epithelium the based of the crypt of Lieberkuhn. Division of these cells serve both to maintain the stem cell population and produce the transit amplifying cells that are all precursors of all cell types that populate the intestinal epithelium." . [] oboInOwl:hasDbXref "DOI:10.1016/j.cell.2013.07.004", "DOI:10.1038/s41575-018-0081-y", "DOI:10.1038/s41580-020-0278-0", "DOI:10.1101/gad.1674008", "DOI:10.1111/j.1365-2184.2009.00642.x" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002250 ; owl:annotatedTarget """Intestinal crypt stem cells, also known as crypt base columnar cells, are a unique type of cell, characterized by the highly specific marker LGR5, found in the intestinal epithelium. Situated at the bottom of the minute pockets known as crypts of Lieberkühn, these are undifferentiated cells that have the ability to perpetually self-renew, as well as differentiate into various other cell types that constitute the epithelial lining of the intestine. The fundamental role of intestinal crypt stem cells is to provide a constant supply of new cells to maintain the cellular turnover of the intestinal epithelium, a tissue known for rapid self-renewal. These stem cells are nurtured and protected by specialized epithelial and mesenchymal cells, and together constitute the intestinal stem cell niche. An important function of intestinal crypt stem cells is to sustain the balance between cell division and programmed cell death, called apoptosis, to ensure the integrity of the intestinal lining. Given their active proliferation rate, these stem cells initiate the creation of diverse differentiated cell types, including enterocytes (the primary absorptive cells in the intestinal lumen), goblet cells (that produce mucus to protect the epithelial layer), enteroendocrine cells (involved in producing gastrointestinal hormones), and Paneth cells (involved in secreting antimicrobial peptides). This diversity in output regulates the physiological activities of the gut ranging from nutrient absorption, hormone secretion, bacterial balance, to immunity. Research studies suggest that dysregulation in intestinal crypt stem cell proliferation and differentiation is associated with several intestinal disorders including intestinal cancer, and various enteropathies. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "intestinal crypt stem cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002250 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002250" . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000148 ; owl:annotatedTarget "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002251 ; owl:annotatedTarget "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." . [] oboInOwl:hasDbXref "DOI:10.1002/med.21754", "DOI:10.1038/nrc.2016.37", "DOI:10.1111/j.1751-1097.2007.00226.x", "DOI:10.3390/ijms21249769", "https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/melanocyte" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0000148 ; owl:annotatedTarget """Melanocytes are specialized cells prevalently found in the skin, but also present in the hair follicles, eyes, inner ear, bones, heart, and brain. Their primary function is the synthesis of melanin, a pigment responsible for coloration of skin, hair, and eyes. The presence and distribution of this pigment play a crucial role in the body's defense mechanism against harmful ultraviolet radiation. In addition to melanin production, melanocytes also engage in a variety of other biological functions. They play a fundamental role in the immune response, owing to their ability to present antigens to T cells. Furthermore, they contribute to the maintenance of the skin's homeostasis by regulating processes such as extracellular matrix remodeling and cytokine production. A balance in melanocyte function is pivotal, as dysfunctions often result in dermatological disorders. For instance, the loss of melanocytes or reduction in their function may lead to hypopigmentation conditions such as vitiligo, whereas an abnormal increase could result in hyperpigmentation disorders or melanoma, a dangerous type of skin cancer. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002252 ; owl:annotatedTarget obo:CL_0002251 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002252 ; owl:annotatedTarget "An epithelial cell of the lining of the esophagus." . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0002252 ; owl:annotatedTarget "ZFA:0009400" ; sssom:mapping_justification . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002253 ; owl:annotatedTarget obo:CL_0002563 . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0000148 ; owl:annotatedTarget "ZFA:0009091" ; sssom:mapping_justification . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002253 ; owl:annotatedTarget "An epithelial cell of the lining of the large intestine." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002254 ; owl:annotatedTarget obo:CL_0002563 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002254 ; owl:annotatedTarget "An epithelial cell of the lining of the small intestine." . [] a owl:Axiom ; rdfs:label "melanocyte on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0000148 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0000148" . [] oboInOwl:hasDbXref "PMID:11331626", "PMID:30013421", "PMID:30309298", "PMID:31907034", "Wikipedia:Decidualization", "https://doi.org/10.1038/s41591-020-1040-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002255 ; owl:annotatedTarget "A stromal cell of the endometrium, characterized by its fibroblast-like morphology, regenerative capacity, and ability to undergo decidualization. It differentiates into a decidual stromal cell during pregnancy, essential for embryo implantation and maintenance. This cell is involved in tissue proliferation, remodeling, and breakdown, responding to hormonal changes, particularly estrogen and progesterone." . [] oboInOwl:hasDbXref "PMID:30309298" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002255 ; owl:annotatedTarget "endometrial stromal fibroblast" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:8985136", "http://www.copewithcytokines.de/cope.cgi?key=glomus%20cells" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002256 ; owl:annotatedTarget "A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002257 ; owl:annotatedTarget "An epithelial cell of thyroid gland." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "PMID:31869123" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002258 ; owl:annotatedTarget "An epithelial cell that is part of the thyroid follicle epithelium, with a shape that ranges from squamous when inactive to cuboidal or columnar when active, reflecting its hormonal activity. Its apical surface is lined with microvilli projecting into the colloid-filled lumen, where it synthesizes, stores, and secretes the thyroid hormones thyroxine (T4) and triiodothyronine (T3), releasing them into the bloodstream in response to thyroid-stimulating hormone (TSH)." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:11687496" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002259 ; owl:annotatedTarget "The stem cell from which glial precursor cell arises from." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002260 ; owl:annotatedTarget "An epithelial cell of the parathyroid gland." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002261 ; owl:annotatedTarget "An endothelial cell found in the mucosa associated with the facial skeleton." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002262 ; owl:annotatedTarget "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." . [] oboInOwl:hasDbXref "DOI:10.1007/s10456-021-09780-y", "DOI:10.1016/j.jhep.2016.07.009", "DOI:10.1038/s41575-018-0020-y", "DOI:10.1038/s41598-020-57652-0", "DOI:10.1186/1476-5926-1-1" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002262 ; owl:annotatedTarget """Endothelial cells of sinusoids, often referred to as sinusoidal endothelial cells (SECs), are a specialized type of endothelial cell that primarily reside in the capillaries of the liver, spleen, and bone marrow. These cells form the innermost monolayer of the sinusoidal blood vessels, also known as sinusoids, that mediate the exchange of nutrients, metabolites, and waste materials between the blood and the surrounding organ tissue. SECs possess distinctive morphological features including a large, flattened shape, an abundance of fenestrations or pores, and the lack of a continuous basement membrane. These structural characteristics distinguish sinusoidal endothelial cells from other, more regularly structured endothelial cells in the body. Due to their special fenestrated structure, SECs facilitate the exchange of macromolecules, like lipoproteins and hyaluronan, between plasma and the surrounding organ parenchymal cells. These fenestrations act like sieves, allowing the passage of substances based on their size and charge. It's noteworthy that the permeability characteristics of SECs can be regulated dynamically according to the body's homeostatic needs. Beyond their key role in exchange mechanisms, endothelial cells of sinusoids are involved in several other functions. In the liver, for example, they help in the removal and endocytic degradation of waste macromolecules, immune response, and regulation of liver regeneration. They also participate in the formation and remodeling of blood vessels, a process known as angiogenesis. Additionally, in recent years, it has been discovered that these cells may have a role in disease conditions like cirrhosis and liver cancer. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; rdfs:label "endothelial cell of sinusoid on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002262 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002262" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0412046911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002263 ; owl:annotatedTarget "One of three types of epithelial cells that populate the parathyroid gland; cytological characteristics intermediate between those of the chief cell and of the oxyphil cell. Because only one hormone is produced, the three cell forms are widely believed to be different phases in the life cycle of a single cell type, with the chief cell being its physiologically active stage." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002264 ; owl:annotatedTarget "A type of enteroendocrine cell found in the stomach that secretes glucagon." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002265 ; owl:annotatedTarget "A D cell located in the colon." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002266 ; owl:annotatedTarget "A type D cell of the small intestine." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002267 ; owl:annotatedTarget "A type D cell found in the stomach." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "PMID:15153415" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002268 ; owl:annotatedTarget "An enteroendocrine cell that stores and secretes Ghrelin." . [] oboInOwl:hasDbXref "GOC:tfm", "ORCID:0000-0002-7073-9172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000150 ; owl:annotatedTarget "An epithelial cell, located in a gland, that is specialised for the synthesis and secretion of specific biomolecules, such as hormones, or mucous." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002269 ; owl:annotatedTarget "An endocrine cell that secretes vasoactive intestinal peptide." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "PMID:15153415" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002270 ; owl:annotatedTarget "A type EC enteroendocrine cell in the duodenum and jejunum that stores and secretes motilin and 5-hydroxytryptamine." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002271 ; owl:annotatedTarget "A type EC enteredocrine cell in the intestines that stores and secretes substance P and 5-hydroxytryptamine." . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D009037" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002272 ; owl:annotatedTarget "A cell that secretes motilin, a gastric hormone that at low pH inhibits gastric motor activity, whereas at high pH has a stimulating effect." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "PMID:15153415" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002273 ; owl:annotatedTarget "A type EC enteroendocrine cell type that is numerous in the fundus of the stomach; stores 5-hydroxytryptamine and histamine." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002274 ; owl:annotatedTarget "A cell type that secretes histamine." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002275 ; owl:annotatedTarget "A PP cell located in the islets of the pancreas." . [] oboInOwl:hasDbXref "DOI:10.1016/B978-0-12-819402-7.00001-2", "DOI:10.1016/B978-012369442-3/50154-9", "DOI:10.1016/j.mce.2015.06.028", "DOI:10.1038/s42255-019-0148-2", "DOI:10.3389/fendo.2023.1192311" ; a owl:Axiom ; owl:annotatedProperty terms:description ; owl:annotatedSource obo:CL_0002275 ; owl:annotatedTarget """Pancreatic polypeptide (PP) cells (also called F or gamma cells) are unique endocrine cells located within the Islets of Langerhans in the pancreas. PP cells are one of the rarer pancreatic cell types and are more prevalent in the head and neck of the pancreas. They are critical in normal pancreatic physiological functions and are involved in the development of pancreatic endocrine disorders. The primary function of PP cells is the production and secretion of the pancreatic polypeptide hormone (PP). This hormone plays a crucial role in several gastrointestinal functions and metabolic responses. The release of the PP hormone is stimulated after eating, especially in protein-rich meals, leading to it being present in large amounts during digestion. The fundamental role of PP is to self-regulate pancreatic secretion activities ensuring its exocrine and endocrine functions are under control. The pancreatic polypeptide hormone from PP cells also aids in adapting to low physical activity and fasting by reducing the production of insulin and glucagon and inhibiting the hepatic glucose production. Additionally, this hormone influences gut motility by slowing down the gastric emptying and reducing small intestinal transit, thereby controlling the pace at which nutritional substances are absorbed. Because of these functions, any malfunction or irregularity in PP cells can result in various disorders such as diabetes and pancreatic diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" . [] a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CL_0002275 ; owl:annotatedTarget "ZFA:0005742" ; sssom:mapping_justification . [] a owl:Axiom ; rdfs:label "pancreatic PP cell on CELLxGENE CellGuide" ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:CL_0002275 ; owl:annotatedTarget "https://cellxgene.cziscience.com/cellguide/CL_0002275" . [] terms:licence ; oboInOwl:hasDbXref "doi:10.48539/HBM637.SFSW.654" ; a owl:Axiom ; owl:annotatedProperty foaf:depiction ; owl:annotatedSource obo:CL_0002275 ; owl:annotatedTarget "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-islets-langerhans/v1.2/assets/2d-ftu-pancreas-islets-langerhans.png" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002276 ; owl:annotatedTarget "OBSOLETE: A PP cell located in the pancreatic acinus. Obsoleted due to a lack of published evidence that this cell type is actually found in the pancreatic acinus." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002277 ; owl:annotatedTarget "An enteroendocrine cell commonest in the duodenum and jejunum, rare in ileum, that secretes cholecystokinin. This cell type is involved in the regulation of digestive enzymes and bile." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002278 ; owl:annotatedTarget "An enteroendocrine cell of duodenum and jejunum that produces gastric inhibitory peptide." . [] oboInOwl:hasDbXref "ISBN:0517223651", "PMID:15153415" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002279 ; owl:annotatedTarget "A enteroendocrine cell type that is numerous in ileum, present in jejunum and large intestine, few in duodenum. This cell type produces glucagon-like immunoreactants (glicentin, glucagon-37, glucagon-29, GLP-1 and -2) and PYY." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002280 ; owl:annotatedTarget "An enteroendocrine cell found in the ileum and jejunum that produces neurotensin." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:15153415" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002281 ; owl:annotatedTarget "Scattered in duodenojejunal mucosa, this enteroendocrine cell secretes secretin and serotonin." . [] oboInOwl:hasDbXref "DOI:10.1007/978-3-211-99390-3", "GOC:tfm", "PMID:7013499" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002282 ; owl:annotatedTarget "An enteroendocrine cell which produces a gastrin- and cholecystokinin-like peptide. The apical microvilli-rich plasma membrane is in open contact with the small intestine mucosa. This cell type is devoid of gastrin-17 but contains other fragments of the gastrin polypeptide." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0323052908" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002283 ; owl:annotatedTarget "An epithelial cell of the mucosa associated with facial skeleton." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20616512" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002284 ; owl:annotatedTarget "An enteroendocrine cell found in the fundus and pylorus; this cell type has dense round secretory granules that contain ghrelin." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "PMID:15738192" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002285 ; owl:annotatedTarget "A taste receptor cell that is characterized by morphologically identifiable synaptic contacts with the gustatory nerve fibers and expression of the synaptic membrane protein-25 (SNAP-25) and NCAM." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:15738192" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002286 ; owl:annotatedTarget "A taste receptor cell that has a short microvilli, a projecting apical region, a large rounded nucleus, and expresses taste chemoreceptors thus making them the transducing cell for taste qualities." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "PMID:15738192" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002287 ; owl:annotatedTarget "A rounded, mitotically active stem cell which is the source of new cells of the taste bud; located basally." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002288 ; owl:annotatedTarget "A cell type that forms the boundary with the surrounding epithelium." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0412046911", "ISBN:0517223651", "PMID:15738192" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002289 ; owl:annotatedTarget "A densely staining taste receptor cell that contains many dense vacuoles in their apical regions which project into the apical space and bear microvilli. This cell type serves as a supporting cell by surrounding and isolating the other cell types from each other; secrete a dense amorphous material that surrounds the microvilli in the taste pore. This cell type expresses a glial glutumate transporter, GLAST." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721669743" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002290 ; owl:annotatedTarget "A sperm bearing a Y chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721669743" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002291 ; owl:annotatedTarget "A sperm bearing an X chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002292 ; owl:annotatedTarget "A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002293 ; owl:annotatedTarget obo:CL_0002076 . [] oboInOwl:hasDbXref "FMA:72208", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002293 ; owl:annotatedTarget "An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:9264335" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002294 ; owl:annotatedTarget "An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule." . [] oboInOwl:hasDbXref "PMID:18194204", "PMID:2694455" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0002294 ; owl:annotatedTarget "subcapsular thymic epithelial cell" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19721455", "PMID:9264335" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002295 ; owl:annotatedTarget "A thymic epithelial cell that has an eccentric, round, or irregularly shaped hetero or euchromatic nucleus. The hallmark of this cell type is the presence of vacuoles, which are clustered in one area of the cytoplasm in the vicinity of the nucleus. The vacuoles are small and acquire a grape-like form, occasionally showing delicate internal microvillous projections." . [] oboInOwl:hasDbXref "FMA:0412046911", "GOC:tfm", "PMID:9264335" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002296 ; owl:annotatedTarget "An epithelial cell with high nuclear and cytoplasmic electron-density. This cell type is found in the deeper portions of the cortex but is more abundant in the medulla of the thymus." . [] oboInOwl:hasDbXref "PMID:9264335" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002297 ; owl:annotatedTarget "A thymic epithelial cell with moderate nuclear and cytoplasmic electron-density. Scattered in the cortex, this cell type is predominant in the mid and deep cortex." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0412046911", "PMID:19721455", "PMID:9264335" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002298 ; owl:annotatedTarget "A thymic epithelial cell type with low nuclear and cytoplasmic electrondensity; has a round, euchromatic nucleus and occurs in small groups at the corticomedullary junction or scattered singly in the medulla." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0412046911", "PMID:9264335" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002299 ; owl:annotatedTarget "An epithelial cell scattered in the cortex, predominant in the outer cortex with a large pale nucleus and a prominent nucleolus." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19721455" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002300 ; owl:annotatedTarget "A small medullary thymic epithelial cell with a spindle shape, often arranged in groups and connected to each other by large desmosomes and interdigitations. The cytoplasm is sparse, with scanty organelles and thick bundles of cytokeratin." .