Minimum PDDI (Potential Drug-Drug Interaction) Information Ontology

A clinically meaningful alteration in the exposure and/or response to a drug (object drug) that has occurred as a result of the co-administration of another drug (precipitant drug)Oates JA. Chapter 5. Goodman and Gilman 11th ed (2006):117–36; Hines. Response can refer to either precipitating an adverse event or altering the therapeutic effect of the object drug. Although some DDIs may be used for therapeutic benefit, this paper focuses on those with adverse clinical consequences. (based on the 2013 DDI conference series) / has participant some mechanism.

An instance of this occurs when at least two or more drugs are taken in a specific time interval and the individual time interval for each drug administration overlaps with the other drug's or drugs' time interval(s). (SG1)

Term and definition provided by Richard D. Boyce.

2/3/2009 Comment from OBI review.

Action specification not well enough specified. Conditional specification not well enough specified. Question whether all plan specifications have objective specifications.

Request that IAO either clarify these or change definitions not to use them

An event is serious when the patient outcome is: Death, Life-threatening Hospitalization (initial or prolonged), disability or permanent damage, congenital anomaly/birth Defect, required intervention to prevent permanent impairment or damage, in involved other important medical events. Source: U.S. Food and Drug Administration. “What is a Serious Adverse Event?” https://urldefense.proofpoint.com/v2/url?u=http-3A__www.fda.gov_Safety_MedWatch_HowToReport_ucm053087.htm&d=DwIGaQ&c=27AKQ-AFTMvLXtgZ7shZqsfSXu-Fwzpqk4BoASshREk&r=_AhKSLG63uT9j7OK4dL0o2DAco1lYASNsYomMJX92ng&m=akNLTN3AxpBiAQmCa5kBvV98eEf8Pl2M-D5MBaU5ANI&s=i_7V5GfnXHZV_wJ4fPZCRVM66e0ZhKlG86F0WWSbxSY&e= (accessed August 19, 2016)

Severity is a term that is too similar to seriousness possibly causing confusion when communicating with clinicians. Moreover, seriousness (like the related term criticality) describes a POTENTIAL impact, whereas severity characterizes a reaction that has been realized in an individual. Since MPIO focuses on potential drug-drug interactions, it cannot include an attribute (severity) that is describing a realized reaction because you are then no longer in the realm of the potential. Finally, the W3C community workgroup that worked on the minimum information model for potential drug-drug interactions greatly preferred the use of an operational classification of risk to a severity rating. Hence, it was obsoleted as a failed exploratory term for the MPIO domain.