@prefix rdf: . @prefix : . @prefix dc: . @prefix obo: . @prefix owl: . @prefix xml: . @prefix xsd: . @prefix foaf: . @prefix rdfs: . @prefix terms: . @prefix protege: . @prefix oboInOwl: . obo:IAO_0000119 "Person:Alan Ruttenberg" . protege:defaultLanguage a owl:AnnotationProperty . obo:APOLLO_SV_00000008 obo:IAO_0000115 "A planned process that has specified output a software product and that involves the creation of source code."@en ; obo:IAO_0000117 "Mathias Brochhausen"@en, "William R. Hogan"@en ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Software_development" ; obo:IAO_0000600 "A planned process resulting in a software product involving the creation of source code."@en ; a owl:Class ; rdfs:label "software development"@en ; rdfs:subClassOf obo:OBI_0000011 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000011 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:IAO_0000010 obo:IAO_0000096 ) ] ] ) ] . obo:APOLLO_SV_00000032 obo:IAO_0000115 "A measurement datum that is the output of counting."@en ; obo:IAO_0000117 "Mathias Brochhausen" ; obo:IAO_0000600 "A measurement datum that is the output of counting."@en ; a owl:Class ; rdfs:label "count"@en ; rdfs:subClassOf obo:IAO_0000109 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:IAO_0000027 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:APOLLO_SV_00000033 ] ) ] . obo:APOLLO_SV_00000033 obo:IAO_0000115 "The planned process of finding the number of elements in a finite set of objects."@en ; obo:IAO_0000117 "Mathias Brochhausen" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Counting" ; obo:IAO_0000600 "The planned process of finding the number of elements in a finite set of objects."@en ; a owl:Class ; rdfs:label "counting"@en ; rdfs:subClassOf obo:OBI_0000011 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000011 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:APOLLO_SV_00000032 ] ) ] . obo:APOLLO_SV_00000522 obo:IAO_0000111 "software source code version control repository"@en ; obo:IAO_0000115 "A document that comprises at least one source code module and provenance data about who contributed the set of files making up the module(s), and optionally comprises also multiple versions of files with detailed change history about who committed files and when, a license for the software, readme files, documentation, executables, etc."@en ; obo:IAO_0000117 "William R. Hogan"@en ; a owl:Class ; rdfs:comment "Refers to the stuff that lives on GitHub, not to GitHub or the git software on which it is based"@en ; rdfs:label "source code repository"@en ; rdfs:subClassOf obo:IAO_0000310, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000096 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:IAO_0000027 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:IAO_0000096 ] ) ] ] . obo:APOLLO_SV_00000524 obo:IAO_0000111 "process of compiling software"@en ; obo:IAO_0000115 "A planned process that converts human-written or curated software into a machine-executable or interpretable set of instructions."@en ; obo:IAO_0000117 "William R. Hogan"@en ; a owl:Class ; rdfs:comment "It's compiling \"software\" (scare quotes) and not \"source code\" because you can compile Java bytecode to machine code, and Java bytecode is not technically \"source code\". Compiling source code would be a subclass of this class (as would compiling Java bytecode, etc.)."@en, "Source code can be automatically generated to some extent, but we're assuming humans still curate it minimally. Also, in the case of Java and its JVM, it's machine interpretable instructions, not directly executable. Ditto for other languages with intermediate form like Java byte code."@en ; rdfs:label "compiling software"@en ; rdfs:subClassOf obo:APOLLO_SV_00000008, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:IAO_0000010 obo:IAO_0000096 ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000010 ] ) ] . obo:APOLLO_SV_00000796 obo:IAO_0000111 "creating a data set"@en ; obo:IAO_0000115 "A planned process that has a data set as its specified output."@en ; obo:IAO_0000117 "William R. Hogan"@en ; obo:IAO_0000118 "data set creation"@en, "dataset creation"@en ; a owl:Class ; rdfs:label "dataset creating"@en ; rdfs:subClassOf obo:OBI_0000011 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000011 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000100 ] ) ] . obo:BFO_0000001 obo:BFO_0000179 "entity" ; obo:BFO_0000180 "Entity" ; obo:IAO_0000112 "Julius Caesar"@en, "Verdi’s Requiem"@en, "the Second World War"@en, "your body mass index"@en ; obo:IAO_0000116 "BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81"@en, "Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf"@en ; obo:IAO_0000600 "An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])"@en ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "entity"@en ; rdfs:subClassOf owl:Thing ; owl:disjointWith oboInOwl:ObsoleteClass . obo:BFO_0000002 obo:BFO_0000179 "continuant" ; obo:BFO_0000180 "Continuant" ; obo:IAO_0000111 "continuant"@en ; obo:IAO_0000115 "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts."@en ; obo:IAO_0000116 "BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240"@en, "Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants"@en ; obo:IAO_0000412 ; obo:IAO_0000600 "A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])"@en ; obo:IAO_0000601 "if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])"@en, "if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])"@en, "if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])"@en ; obo:IAO_0000602 "(forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] ", "(forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] ", "(forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] ", "(forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "continuant"@en ; rdfs:subClassOf obo:BFO_0000001 ; owl:disjointWith obo:BFO_0000003, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:BFO_0000003 ] . obo:BFO_0000003 obo:BFO_0000179 "occurrent" ; obo:BFO_0000180 "Occurrent" ; obo:IAO_0000115 "An entity that has temporal parts and that happens, unfolds or develops through time."@en ; obo:IAO_0000116 "BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region"@en, "BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players."@en, "Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process."@en, "Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame." ; obo:IAO_0000600 "An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])"@en ; obo:IAO_0000601 "Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])"@en, "b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])"@en ; obo:IAO_0000602 "(forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] ", "(forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "occurrent"@en ; rdfs:subClassOf obo:BFO_0000001 ; owl:disjointWith [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:BFO_0000002 ] . obo:BFO_0000004 obo:BFO_0000179 "ic" ; obo:BFO_0000180 "IndependentContinuant" ; obo:IAO_0000112 "a chair"@en, "a heart"@en, "a leg"@en, "a molecule"@en, "a spatial region"@en, "an atom"@en, "an orchestra."@en, "an organism"@en, "the bottom right portion of a human torso"@en, "the interior of your mouth"@en ; obo:IAO_0000115 "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything."@en, "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])"@en ; obo:IAO_0000601 "For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])"@en, "For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])"@en ; obo:IAO_0000602 "(forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] ", "(forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] ", "(iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "independent continuant"@en ; rdfs:subClassOf obo:BFO_0000002 ; owl:disjointWith obo:BFO_0000020, obo:BFO_0000031 . obo:BFO_0000005 obo:IAO_0000115 "A continuant that is either dependent on one or other independent continuant bearers or inheres in or is borne by other entities."@en ; a owl:Class ; rdfs:label "obsolete dependent continuant"@en ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:BFO_0000006 obo:BFO_0000179 "s-region" ; obo:BFO_0000180 "SpatialRegion" ; obo:IAO_0000116 "BFO 2 Reference: Spatial regions do not participate in processes."@en, "Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional."@en ; obo:IAO_0000600 "A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001])"@en ; obo:IAO_0000601 "All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001])"@en ; obo:IAO_0000602 "(forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001] ", "(forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "spatial region"@en ; rdfs:subClassOf obo:BFO_0000141 ; owl:disjointWith obo:BFO_0000029, obo:BFO_0000140 . obo:BFO_0000008 obo:BFO_0000179 "t-region" ; obo:BFO_0000180 "TemporalRegion" ; obo:IAO_0000116 "Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional"@en ; obo:IAO_0000600 "A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001])"@en ; obo:IAO_0000601 "All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001])"@en, "Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002])"@en ; obo:IAO_0000602 "(forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002] ", "(forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001] ", "(forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "temporal region"@en ; rdfs:subClassOf obo:BFO_0000003 ; owl:disjointWith obo:BFO_0000011, obo:BFO_0000015, obo:BFO_0000035 . obo:BFO_0000009 obo:BFO_0000179 "2d-s-region" ; obo:BFO_0000180 "TwoDimensionalSpatialRegion" ; obo:IAO_0000112 "an infinitely thin plane in space."@en, "the surface of a sphere-shaped part of space"@en ; obo:IAO_0000600 "A two-dimensional spatial region is a spatial region that is of two dimensions. (axiom label in BFO2 Reference: [039-001])"@en ; obo:IAO_0000602 "(forall (x) (if (TwoDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [039-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "two-dimensional spatial region"@en ; rdfs:subClassOf obo:BFO_0000006 ; owl:disjointWith obo:BFO_0000028 . obo:BFO_0000011 obo:BFO_0000179 "st-region" ; obo:BFO_0000180 "SpatiotemporalRegion" ; obo:IAO_0000112 "the spatiotemporal region occupied by a human life"@en, "the spatiotemporal region occupied by a process of cellular meiosis."@en, "the spatiotemporal region occupied by the development of a cancer tumor"@en ; obo:IAO_0000600 "A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001])"@en ; obo:IAO_0000601 "All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001])"@en, "Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001])"@en, "Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001])"@en, "Every spatiotemporal region occupies_spatiotemporal_region itself."@en, "Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002])"@en ; obo:IAO_0000602 "(forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002] ", "(forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001] ", "(forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001] ", "(forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001] ", "(forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "spatiotemporal region"@en ; rdfs:subClassOf obo:BFO_0000003 . obo:BFO_0000015 obo:BFO_0000179 "process" ; obo:BFO_0000180 "Process" ; obo:IAO_0000112 "a process of cell-division, \\ a beating of the heart"@en, "a process of meiosis"@en, "a process of sleeping"@en, "the course of a disease"@en, "the flight of a bird"@en, "the life of an organism"@en, "your process of aging."@en ; obo:IAO_0000115 "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t."@en, "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])"@en ; obo:IAO_0000116 "BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)"@en ; obo:IAO_0000602 "(iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "process"@en ; rdfs:subClassOf obo:BFO_0000003 . obo:BFO_0000016 obo:BFO_0000179 "disposition" ; obo:BFO_0000180 "Disposition" ; obo:IAO_0000112 "an atom of element X has the disposition to decay to an atom of element Y"@en, "certain people have a predisposition to colon cancer"@en, "children are innately disposed to categorize objects in certain ways."@en, "the cell wall is disposed to filter chemicals in endocytosis and exocytosis"@en ; obo:IAO_0000116 "BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type."@en ; obo:IAO_0000600 "b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])"@en ; obo:IAO_0000601 "If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])"@en ; obo:IAO_0000602 "(forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] ", "(forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "disposition"@en ; rdfs:subClassOf obo:BFO_0000017 ; owl:disjointWith obo:BFO_0000023 . obo:BFO_0000017 obo:BFO_0000179 "realizable" ; obo:BFO_0000180 "RealizableEntity" ; obo:IAO_0000112 "the disposition of this piece of metal to conduct electricity."@en, "the disposition of your blood to coagulate"@en, "the function of your reproductive organs"@en, "the role of being a doctor"@en, "the role of this boundary to delineate where Utah and Colorado meet"@en ; obo:IAO_0000115 "A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances."@en ; obo:IAO_0000600 "To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])"@en ; obo:IAO_0000601 "All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])"@en ; obo:IAO_0000602 "(forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] ", "(forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "realizable entity"@en ; rdfs:subClassOf obo:BFO_0000020 ; owl:disjointWith obo:BFO_0000019 . obo:BFO_0000018 obo:BFO_0000179 "0d-s-region" ; obo:BFO_0000180 "ZeroDimensionalSpatialRegion" ; obo:IAO_0000600 "A zero-dimensional spatial region is a point in space. (axiom label in BFO2 Reference: [037-001])"@en ; obo:IAO_0000602 "(forall (x) (if (ZeroDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [037-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "zero-dimensional spatial region"@en ; rdfs:subClassOf obo:BFO_0000006 ; owl:disjointWith obo:BFO_0000028 . obo:BFO_0000019 obo:BFO_0000179 "quality" ; obo:BFO_0000180 "Quality" ; obo:IAO_0000111 "quality"@en ; obo:IAO_0000112 "the ambient temperature of this portion of air"@en, "the color of a tomato"@en, "the length of the circumference of your waist"@en, "the mass of this piece of gold."@en, "the shape of your nose"@en, "the shape of your nostril"@en ; obo:IAO_0000412 ; obo:IAO_0000600 "a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])"@en ; obo:IAO_0000601 "If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])"@en ; obo:IAO_0000602 "(forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] ", "(forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "quality"@en ; rdfs:subClassOf obo:BFO_0000020 . obo:BFO_0000020 obo:BFO_0000179 "sdc" ; obo:BFO_0000180 "SpecificallyDependentContinuant" ; obo:IAO_0000111 "specifically dependent continuant"@en ; obo:IAO_0000112 "Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key"@en, "of one-sided specifically dependent continuants: the mass of this tomato"@en, "of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates."@en, "the disposition of this fish to decay"@en, "the function of this heart: to pump blood"@en, "the mutual dependence of proton donors and acceptors in chemical reactions [79"@en, "the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction"@en, "the pink color of a medium rare piece of grilled filet mignon at its center"@en, "the role of being a doctor"@en, "the shape of this hole."@en, "the smell of this portion of mozzarella"@en ; obo:IAO_0000115 "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same."@en, "b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n > 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i < j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004])"@en, "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])"@en ; obo:IAO_0000116 "Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc."@en ; obo:IAO_0000412 ; obo:IAO_0000602 "(iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004] ", "(iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "specifically dependent continuant"@en ; rdfs:subClassOf obo:BFO_0000002 ; owl:disjointWith obo:BFO_0000031 . obo:BFO_0000023 obo:BFO_0000179 "role" ; obo:BFO_0000180 "Role" ; obo:IAO_0000112 "John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married."@en, "the priest role"@en, "the role of a boundary to demarcate two neighboring administrative territories"@en, "the role of a building in serving as a military target"@en, "the role of a stone in marking a property boundary"@en, "the role of subject in a clinical trial"@en, "the student role"@en ; obo:IAO_0000115 "A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts."@en ; obo:IAO_0000116 "BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives."@en ; obo:IAO_0000600 "b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])"@en ; obo:IAO_0000602 "(forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "role"@en ; rdfs:subClassOf obo:BFO_0000017 . obo:BFO_0000024 obo:BFO_0000179 "fiat-object", "fiat-object-part" ; obo:BFO_0000180 "FiatObjectPart" ; obo:IAO_0000112 "or with divisions drawn by cognitive subjects for practical reasons, such as the division of a cake (before slicing) into (what will become) slices (and thus member parts of an object aggregate). However, this does not mean that fiat object parts are dependent for their existence on divisions or delineations effected by cognitive subjects. If, for example, it is correct to conceive geological layers of the Earth as fiat object parts of the Earth, then even though these layers were first delineated in recent times, still existed long before such delineation and what holds of these layers (for example that the oldest layers are also the lowest layers) did not begin to hold because of our acts of delineation.Treatment of material entity in BFOExamples viewed by some as problematic cases for the trichotomy of fiat object part, object, and object aggregate include: a mussel on (and attached to) a rock, a slime mold, a pizza, a cloud, a galaxy, a railway train with engine and multiple carriages, a clonal stand of quaking aspen, a bacterial community (biofilm), a broken femur. Note that, as Aristotle already clearly recognized, such problematic cases – which lie at or near the penumbra of instances defined by the categories in question – need not invalidate these categories. The existence of grey objects does not prove that there are not objects which are black and objects which are white; the existence of mules does not prove that there are not objects which are donkeys and objects which are horses. It does, however, show that the examples in question need to be addressed carefully in order to show how they can be fitted into the proposed scheme, for example by recognizing additional subdivisions [29"@en, "the FMA:regional parts of an intact human body."@en, "the Western hemisphere of the Earth"@en, "the division of the brain into regions"@en, "the division of the planet into hemispheres"@en, "the dorsal and ventral surfaces of the body"@en, "the upper and lower lobes of the left lung"@en ; obo:IAO_0000116 "BFO 2 Reference: Most examples of fiat object parts are associated with theoretically drawn divisions"@en ; obo:IAO_0000600 "b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004])"@en ; obo:IAO_0000602 "(forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "fiat object"@en, "fiat object part"@en ; rdfs:subClassOf obo:BFO_0000040 . obo:BFO_0000026 obo:BFO_0000179 "1d-s-region" ; obo:BFO_0000180 "OneDimensionalSpatialRegion" ; obo:IAO_0000112 "an edge of a cube-shaped portion of space."@en ; obo:IAO_0000600 "A one-dimensional spatial region is a line or aggregate of lines stretching from one point in space to another. (axiom label in BFO2 Reference: [038-001])"@en ; obo:IAO_0000602 "(forall (x) (if (OneDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [038-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "one-dimensional spatial region"@en ; rdfs:subClassOf obo:BFO_0000006 ; owl:disjointWith obo:BFO_0000028 . obo:BFO_0000027 obo:BFO_0000179 "object-aggregate" ; obo:BFO_0000180 "ObjectAggregate" ; obo:IAO_0000112 "a collection of cells in a blood biobank."@en, "a swarm of bees is an aggregate of members who are linked together through natural bonds"@en, "a symphony orchestra"@en, "an organization is an aggregate whose member parts have roles of specific types (for example in a jazz band, a chess club, a football team)"@en, "defined by fiat: the aggregate of members of an organization"@en, "defined through physical attachment: the aggregate of atoms in a lump of granite"@en, "defined through physical containment: the aggregate of molecules of carbon dioxide in a sealed container"@en, "defined via attributive delimitations such as: the patients in this hospital"@en, "the aggregate of bearings in a constant velocity axle joint"@en, "the aggregate of blood cells in your body"@en, "the nitrogen atoms in the atmosphere"@en, "the restaurants in Palo Alto"@en, "your collection of Meissen ceramic plates."@en ; obo:IAO_0000116 "An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects ", "BFO 2 Reference: object aggregates may gain and lose parts while remaining numerically identical (one and the same individual) over time. This holds both for aggregates whose membership is determined naturally (the aggregate of cells in your body) and aggregates determined by fiat (a baseball team, a congressional committee)."@en ; obo:IAO_0000119 "ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158." ; obo:IAO_0000600 "b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004])"@en ; obo:IAO_0000602 "(forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "object aggregate"@en ; rdfs:subClassOf obo:BFO_0000040 . obo:BFO_0000028 obo:BFO_0000179 "3d-s-region" ; obo:BFO_0000180 "ThreeDimensionalSpatialRegion" ; obo:IAO_0000112 "a cube-shaped region of space"@en, "a sphere-shaped region of space,"@en ; obo:IAO_0000600 "A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001])"@en ; obo:IAO_0000602 "(forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "three-dimensional spatial region"@en ; rdfs:subClassOf obo:BFO_0000006 . obo:BFO_0000029 obo:BFO_0000179 "site" ; obo:BFO_0000180 "Site" ; obo:IAO_0000112 "Manhattan Canyon)"@en, "a hole in the interior of a portion of cheese"@en, "a rabbit hole"@en, "an air traffic control region defined in the airspace above an airport"@en, "the Grand Canyon"@en, "the Piazza San Marco"@en, "the cockpit of an aircraft"@en, "the hold of a ship"@en, "the interior of a kangaroo pouch"@en, "the interior of the trunk of your car"@en, "the interior of your bedroom"@en, "the interior of your office"@en, "the interior of your refrigerator"@en, "the lumen of your gut"@en, "your left nostril (a fiat part – the opening – of your left nasal cavity)"@en ; obo:IAO_0000600 "b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002])"@en ; obo:IAO_0000602 "(forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "site"@en ; rdfs:subClassOf obo:BFO_0000141 . obo:BFO_0000030 obo:BFO_0000179 "object" ; obo:BFO_0000180 "Object" ; obo:IAO_0000112 "atom"@en, "cell"@en, "cells and organisms"@en, "engineered artifacts"@en, "grain of sand"@en, "molecule"@en, "organelle"@en, "organism"@en, "planet"@en, "solid portions of matter"@en, "star"@en ; obo:IAO_0000116 "BFO 2 Reference: BFO rests on the presupposition that at multiple micro-, meso- and macroscopic scales reality exhibits certain stable, spatially separated or separable material units, combined or combinable into aggregates of various sorts (for example organisms into what are called ‘populations’). Such units play a central role in almost all domains of natural science from particle physics to cosmology. Many scientific laws govern the units in question, employing general terms (such as ‘molecule’ or ‘planet’) referring to the types and subtypes of units, and also to the types and subtypes of the processes through which such units develop and interact. The division of reality into such natural units is at the heart of biological science, as also is the fact that these units may form higher-level units (as cells form multicellular organisms) and that they may also form aggregates of units, for example as cells form portions of tissue and organs form families, herds, breeds, species, and so on. At the same time, the division of certain portions of reality into engineered units (manufactured artifacts) is the basis of modern industrial technology, which rests on the distributed mass production of engineered parts through division of labor and on their assembly into larger, compound units such as cars and laptops. The division of portions of reality into units is one starting point for the phenomenon of counting."@en, "BFO 2 Reference: Each object is such that there are entities of which we can assert unproblematically that they lie in its interior, and other entities of which we can assert unproblematically that they lie in its exterior. This may not be so for entities lying at or near the boundary between the interior and exterior. This means that two objects – for example the two cells depicted in Figure 3 – may be such that there are material entities crossing their boundaries which belong determinately to neither cell. Something similar obtains in certain cases of conjoined twins (see below)."@en, "BFO 2 Reference: To say that b is causally unified means: b is a material entity which is such that its material parts are tied together in such a way that, in environments typical for entities of the type in question,if c, a continuant part of b that is in the interior of b at t, is larger than a certain threshold size (which will be determined differently from case to case, depending on factors such as porosity of external cover) and is moved in space to be at t at a location on the exterior of the spatial region that had been occupied by b at t, then either b’s other parts will be moved in coordinated fashion or b will be damaged (be affected, for example, by breakage or tearing) in the interval between t and t.causal changes in one part of b can have consequences for other parts of b without the mediation of any entity that lies on the exterior of b. Material entities with no proper material parts would satisfy these conditions trivially. Candidate examples of types of causal unity for material entities of more complex sorts are as follows (this is not intended to be an exhaustive list):CU1: Causal unity via physical coveringHere the parts in the interior of the unified entity are combined together causally through a common membrane or other physical covering\\. The latter points outwards toward and may serve a protective function in relation to what lies on the exterior of the entity [13, 47"@en, "BFO 2 Reference: an object is a maximal causally unified material entity"@en, "BFO 2 Reference: ‘objects’ are sometimes referred to as ‘grains’ [74"@en ; obo:IAO_0000600 "b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001])"@en ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "object"@en ; rdfs:subClassOf obo:BFO_0000040 . obo:BFO_0000031 obo:BFO_0000179 "gdc" ; obo:BFO_0000180 "GenericallyDependentContinuant" ; obo:IAO_0000112 "The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity."@en, "the pdf file on your laptop, the pdf file that is a copy thereof on my laptop"@en, "the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule."@en ; obo:IAO_0000115 "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time."@en, "b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])"@en ; obo:IAO_0000602 "(iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "generically dependent continuant"@en ; rdfs:subClassOf obo:BFO_0000002 . obo:BFO_0000034 obo:BFO_0000179 "function" ; obo:BFO_0000180 "Function" ; obo:IAO_0000112 "the function of a hammer to drive in nails"@en, "the function of a heart pacemaker to regulate the beating of a heart through electricity"@en, "the function of amylase in saliva to break down starch into sugar"@en ; obo:IAO_0000116 "BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc."@en ; obo:IAO_0000600 "A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])"@en ; obo:IAO_0000602 "(forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "function"@en ; rdfs:subClassOf obo:BFO_0000016 . obo:BFO_0000035 obo:BFO_0000179 "p-boundary" ; obo:BFO_0000180 "ProcessBoundary" ; obo:IAO_0000112 "the boundary between the 2nd and 3rd year of your life."@en ; obo:IAO_0000115 "p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001])"@en ; obo:IAO_0000601 "Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002])"@en ; obo:IAO_0000602 "(forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002] ", "(iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "process boundary"@en ; rdfs:subClassOf obo:BFO_0000003 . obo:BFO_0000038 obo:BFO_0000179 "1d-t-region" ; obo:BFO_0000180 "OneDimensionalTemporalRegion" ; obo:IAO_0000112 "the temporal region during which a process occurs."@en ; obo:IAO_0000116 "BFO 2 Reference: A temporal interval is a special kind of one-dimensional temporal region, namely one that is self-connected (is without gaps or breaks)."@en ; obo:IAO_0000600 "A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001])"@en ; obo:IAO_0000602 "(forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "one-dimensional temporal region"@en ; rdfs:subClassOf obo:BFO_0000008 ; owl:disjointWith obo:BFO_0000148 . obo:BFO_0000040 obo:BFO_0000179 "material" ; obo:BFO_0000180 "MaterialEntity" ; obo:IAO_0000111 "material entity"@en ; obo:IAO_0000112 "a flame"@en, "a forest fire"@en, "a human being"@en, "a hurricane"@en, "a photon"@en, "a puff of smoke"@en, "a sea wave"@en, "a tornado"@en, "an aggregate of human beings."@en, "an energy wave"@en, "an epidemic"@en, "the undetached arm of a human being"@en ; obo:IAO_0000115 "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time."@en ; obo:IAO_0000116 "BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60"@en, "BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity."@en, "BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here."@en ; obo:IAO_0000412 , , ; obo:IAO_0000600 "A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])"@en ; obo:IAO_0000601 "Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])"@en, "every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])"@en ; obo:IAO_0000602 "(forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] ", "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] ", "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "material entity"@en ; rdfs:subClassOf obo:BFO_0000004 ; owl:disjointWith obo:BFO_0000141 . obo:BFO_0000050 obo:IAO_0000111 "is part of"@en ; obo:IAO_0000112 "my brain is part of my body (continuant parthood, two material entities)"@en, "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)"@en, "this day is part of this year (occurrent parthood)"@en ; obo:IAO_0000115 "a core relation that holds between a part and its whole"@en ; obo:IAO_0000116 "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other."@en, "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime"@en, """Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'."""@en ; obo:IAO_0000118 "part_of"@en ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "part of"@en ; rdfs:seeAlso "http://www.obofoundry.org/ro/#OBO_REL:part_of" ; owl:inverseOf obo:BFO_0000051 . obo:BFO_0000051 obo:IAO_0000111 "has part"@en ; obo:IAO_0000112 "my body has part my brain (continuant parthood, two material entities)"@en, "my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)"@en, "this year has part this day (occurrent parthood)"@en ; obo:IAO_0000115 "a core relation that holds between a whole and its part"@en ; obo:IAO_0000116 "Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part."@en, "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime"@en, """Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'."""@en ; obo:IAO_0000118 "has_part"@en ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "has part"@en . obo:BFO_0000054 obo:IAO_0000111 "realized in"@en ; obo:IAO_0000112 "this disease is realized in this disease course"@en, "this fragility is realized in this shattering"@en, "this investigator role is realized in this investigation"@en ; obo:IAO_0000118 "is realized by"@en, "realized_in"@en ; obo:IAO_0000600 "[copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])"@en ; a owl:ObjectProperty ; rdfs:comment "Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process" ; rdfs:domain obo:BFO_0000017 ; rdfs:isDefinedBy ; rdfs:label "realized in"@en ; rdfs:range obo:BFO_0000015 ; owl:inverseOf obo:BFO_0000055 . obo:BFO_0000055 obo:IAO_0000111 "realizes"@en ; obo:IAO_0000112 "this disease course realizes this disease"@en, "this investigation realizes this investigator role"@en, "this shattering realizes this fragility"@en ; obo:IAO_0000600 "to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])"@en ; a owl:ObjectProperty ; rdfs:comment "Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process" ; rdfs:domain obo:BFO_0000015 ; rdfs:isDefinedBy ; rdfs:label "realizes"@en ; rdfs:range obo:BFO_0000017 . obo:BFO_0000062 obo:IAO_0000111 "preceded by"@en ; obo:IAO_0000116 "An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other."@en ; obo:IAO_0000118 "is preceded by"@en, "preceded_by"@en ; dc:source "http://www.obofoundry.org/ro/#OBO_REL:preceded_by" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:domain obo:BFO_0000003 ; rdfs:label "preceded by"@en ; rdfs:range obo:BFO_0000003 ; owl:inverseOf obo:BFO_0000063 . obo:BFO_0000063 obo:IAO_0000111 "precedes"@en ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:domain obo:BFO_0000003 ; rdfs:label "precedes"@en ; rdfs:range obo:BFO_0000003 ; rdfs:subPropertyOf obo:RO_0002222 . obo:BFO_0000066 obo:IAO_0000111 "occurs in"@en ; obo:IAO_0000115 "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t"@en ; obo:IAO_0000118 "occurs_in"@en, "unfolds in"@en, "unfolds_in"@en ; a owl:ObjectProperty ; rdfs:comment "Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant" ; rdfs:domain obo:BFO_0000003 ; rdfs:isDefinedBy ; rdfs:label "occurs in"@en ; rdfs:range obo:BFO_0000004 ; owl:inverseOf obo:BFO_0000067 ; owl:propertyChainAxiom (obo:BFO_0000050 obo:BFO_0000066 ), (obo:BFO_0000066 obo:BFO_0000050 ) . obo:BFO_0000067 obo:IAO_0000111 "site of"@en ; obo:IAO_0000115 "[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t"@en ; a owl:ObjectProperty ; rdfs:comment "Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant" ; rdfs:isDefinedBy ; rdfs:label "contains process"@en . obo:BFO_0000134 obo:IAO_0000600 "To say that each spatiotemporal region s temporally_projects_onto some temporal region t is to say that t is the temporal extension of s. (axiom label in BFO2 Reference: [080-003])"@en, "To say that spatiotemporal region s spatially_projects_onto spatial region r at t is to say that r is the spatial extent of s at t. (axiom label in BFO2 Reference: [081-003])"@en . obo:BFO_0000140 obo:BFO_0000179 "cf-boundary" ; obo:BFO_0000180 "ContinuantFiatBoundary" ; obo:IAO_0000115 "b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001])"@en ; obo:IAO_0000116 "BFO 2 Reference: In BFO 1.1 the assumption was made that the external surface of a material entity such as a cell could be treated as if it were a boundary in the mathematical sense. The new document propounds the view that when we talk about external surfaces of material objects in this way then we are talking about something fiat. To be dealt with in a future version: fiat boundaries at different levels of granularity.More generally, the focus in discussion of boundaries in BFO 2.0 is now on fiat boundaries, which means: boundaries for which there is no assumption that they coincide with physical discontinuities. The ontology of boundaries becomes more closely allied with the ontology of regions."@en, "BFO 2 Reference: a continuant fiat boundary is a boundary of some material entity (for example: the plane separating the Northern and Southern hemispheres; the North Pole), or it is a boundary of some immaterial entity (for example of some portion of airspace). Three basic kinds of continuant fiat boundary can be distinguished (together with various combination kinds [29"@en, "Continuant fiat boundary doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the mereological sum of two-dimensional continuant fiat boundary and a one dimensional continuant fiat boundary that doesn't overlap it. The situation is analogous to temporal and spatial regions."@en ; obo:IAO_0000601 "Every continuant fiat boundary is located at some spatial region at every time at which it exists"@en ; obo:IAO_0000602 "(iff (ContinuantFiatBoundary a) (and (ImmaterialEntity a) (exists (b) (and (or (ZeroDimensionalSpatialRegion b) (OneDimensionalSpatialRegion b) (TwoDimensionalSpatialRegion b)) (forall (t) (locatedInAt a b t)))) (not (exists (c t) (and (SpatialRegion c) (continuantPartOfAt c a t)))))) // axiom label in BFO2 CLIF: [029-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "continuant fiat boundary"@en ; rdfs:subClassOf obo:BFO_0000141 . obo:BFO_0000141 obo:BFO_0000179 "immaterial" ; obo:BFO_0000180 "ImmaterialEntity" ; obo:IAO_0000116 "BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10"@en ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "immaterial entity"@en ; rdfs:subClassOf obo:BFO_0000004 . obo:BFO_0000142 obo:BFO_0000179 "1d-cf-boundary" ; obo:BFO_0000180 "OneDimensionalContinuantFiatBoundary" ; obo:IAO_0000112 "The Equator"@en, "all geopolitical boundaries"@en, "all lines of latitude and longitude"@en, "the line separating the outer surface of the mucosa of the lower lip from the outer surface of the skin of the chin."@en, "the median sulcus of your tongue"@en ; obo:IAO_0000600 "a one-dimensional continuant fiat boundary is a continuous fiat line whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [032-001])"@en ; obo:IAO_0000602 "(iff (OneDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (OneDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [032-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "one-dimensional continuant fiat boundary"@en ; rdfs:subClassOf obo:BFO_0000140 ; owl:disjointWith obo:BFO_0000146, obo:BFO_0000147 . obo:BFO_0000144 obo:BFO_0000179 "process-profile" ; obo:BFO_0000180 "ProcessProfile" ; obo:IAO_0000112 "On a somewhat higher level of complexity are what we shall call rate process profiles, which are the targets of selective abstraction focused not on determinate quality magnitudes plotted over time, but rather on certain ratios between these magnitudes and elapsed times. A speed process profile, for example, is represented by a graph plotting against time the ratio of distance covered per unit of time. Since rates may change, and since such changes, too, may have rates of change, we have to deal here with a hierarchy of process profile universals at successive levels"@en, "One important sub-family of rate process profiles is illustrated by the beat or frequency profiles of cyclical processes, illustrated by the 60 beats per minute beating process of John’s heart, or the 120 beats per minute drumming process involved in one of John’s performances in a rock band, and so on. Each such process includes what we shall call a beat process profile instance as part, a subtype of rate process profile in which the salient ratio is not distance covered but rather number of beat cycles per unit of time. Each beat process profile instance instantiates the determinable universal beat process profile. But it also instantiates multiple more specialized universals at lower levels of generality, selected from rate process profilebeat process profileregular beat process profile3 bpm beat process profile4 bpm beat process profileirregular beat process profileincreasing beat process profileand so on.In the case of a regular beat process profile, a rate can be assigned in the simplest possible fashion by dividing the number of cycles by the length of the temporal region occupied by the beating process profile as a whole. Irregular process profiles of this sort, for example as identified in the clinic, or in the readings on an aircraft instrument panel, are often of diagnostic significance."@en, "The simplest type of process profiles are what we shall call ‘quality process profiles’, which are the process profiles which serve as the foci of the sort of selective abstraction that is involved when measurements are made of changes in single qualities, as illustrated, for example, by process profiles of mass, temperature, aortic pressure, and so on."@en ; obo:IAO_0000115 "b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])"@en ; obo:IAO_0000600 "b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005])"@en ; obo:IAO_0000602 "(forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005] ", "(iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "process profile"@en ; rdfs:subClassOf obo:BFO_0000015 ; owl:disjointWith obo:BFO_0000182 . obo:BFO_0000145 obo:BFO_0000179 "r-quality" ; obo:BFO_0000180 "RelationalQuality" ; obo:IAO_0000112 "John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married."@en, "a marriage bond, an instance of love, an obligation between one person and another."@en, "a marriage bond, an instance of requited love, an obligation between one person and another."@en ; obo:IAO_0000115 "b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001])"@en ; obo:IAO_0000602 "(iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "relational quality"@en ; rdfs:subClassOf obo:BFO_0000019 . obo:BFO_0000146 obo:BFO_0000179 "2d-cf-boundary" ; obo:BFO_0000180 "TwoDimensionalContinuantFiatBoundary" ; obo:IAO_0000600 "a two-dimensional continuant fiat boundary (surface) is a self-connected fiat surface whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [033-001])"@en ; obo:IAO_0000602 "(iff (TwoDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (TwoDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [033-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "two-dimensional continuant fiat boundary"@en ; rdfs:subClassOf obo:BFO_0000140 . obo:BFO_0000147 obo:BFO_0000179 "0d-cf-boundary" ; obo:BFO_0000180 "ZeroDimensionalContinuantFiatBoundary" ; obo:IAO_0000112 "the geographic North Pole"@en, "the point of origin of some spatial coordinate system."@en, "the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet"@en ; obo:IAO_0000116 "zero dimension continuant fiat boundaries are not spatial points. Considering the example 'the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet' : There are many frames in which that point is zooming through many points in space. Whereas, no matter what the frame, the quadripoint is always in the same relation to the boundaries of Colorado, Utah, New Mexico, and Arizona."@en ; obo:IAO_0000600 "a zero-dimensional continuant fiat boundary is a fiat point whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [031-001])"@en ; obo:IAO_0000602 "(iff (ZeroDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (ZeroDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [031-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "zero-dimensional continuant fiat boundary"@en ; rdfs:subClassOf obo:BFO_0000140 . obo:BFO_0000148 obo:BFO_0000179 "0d-t-region" ; obo:BFO_0000180 "ZeroDimensionalTemporalRegion" ; obo:IAO_0000112 "a temporal region that is occupied by a process boundary"@en, "right now"@en, "the moment at which a child is born"@en, "the moment at which a finger is detached in an industrial accident"@en, "the moment of death."@en ; obo:IAO_0000118 "temporal instant."@en ; obo:IAO_0000600 "A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001])"@en ; obo:IAO_0000602 "(forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001] " ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "zero-dimensional temporal region"@en ; rdfs:subClassOf obo:BFO_0000008 . obo:BFO_0000179 obo:IAO_0000115 "Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification."@en ; obo:IAO_0000232 "Really of interest to developers only"@en ; a owl:AnnotationProperty ; rdfs:label "BFO OWL specification label"@en ; rdfs:subPropertyOf rdfs:label . obo:BFO_0000180 obo:IAO_0000115 "Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2"@en ; obo:IAO_0000119 "Person:Alan Ruttenberg" ; obo:IAO_0000232 "Really of interest to developers only"@en ; a owl:AnnotationProperty ; rdfs:label "BFO CLIF specification label"@en ; rdfs:subPropertyOf rdfs:label . obo:BFO_0000182 obo:BFO_0000179 "history" ; obo:BFO_0000180 "History" ; obo:IAO_0000600 "A history is a process that is the sum of the totality of processes taking place in the spatiotemporal region occupied by a material entity or site, including processes on the surface of the entity or within the cavities to which it serves as host. (axiom label in BFO2 Reference: [138-001])"@en ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "history"@en ; rdfs:subClassOf obo:BFO_0000015 . obo:CHEBI_145810 obo:IAO_0000111 "insulin" ; obo:IAO_0000115 "A peptide hormone which consists of two polypeptide chains, A- and B- chains which are linked together by disulfide bonds. The amino acid sequence of insulin varies across species and certain segments of the molecule are highly conserved. In most species, the A chain consists of 21 amino acids and the B chain consists of 30 amino acids. In mammals, insulin is synthesised in the pancreas within the beta cells whereas in certain species of fish, the insulin-producing tissue is uniquely located in separate structures called Brockmann bodies." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "insulin" ; rdfs:subClassOf obo:CHEBI_16670 . obo:CHEBI_15377 obo:IAO_0000111 "water" ; obo:IAO_0000115 "An oxygen hydride consisting of an oxygen atom that is covalently bonded to two hydrogen atoms." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "water" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_15422 obo:IAO_0000111 "ATP" ; obo:IAO_0000115 "An adenosine 5'-phosphate in which the 5'-phosphate is a triphosphate group. It is involved in the transportation of chemical energy during metabolic pathways." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ATP" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_15956 obo:IAO_0000111 "biotin" ; obo:IAO_0000115 "An organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "biotin" ; rdfs:subClassOf obo:OBI_0002744, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0002743 ] . obo:CHEBI_16113 obo:IAO_0000111 "cholesterol" ; obo:IAO_0000115 "A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cholesterol" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_16134 obo:IAO_0000111 "ammonia" ; obo:IAO_0000115 "An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ammonia" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_16247 obo:IAO_0000111 "phospholipid" ; obo:IAO_0000115 "A lipid containing phosphoric acid as a mono- or di-ester. The term encompasses phosphatidic acids and phosphoglycerides." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "phospholipid" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_16301 obo:IAO_0000111 "nitrite" ; obo:IAO_0000115 "The nitrogen oxoanion formed by loss of a proton from nitrous acid." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "nitrite" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_16526 obo:IAO_0000111 "carbon dioxide" ; obo:IAO_0000115 "A one-carbon compound with formula CO2 in which the carbon is attached to each oxygen atom by a double bond. A colourless, odourless gas under normal conditions, it is produced during respiration by all animals, fungi and microorganisms that depend directly or indirectly on living or decaying plants for food." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "carbon dioxide" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_16670 obo:IAO_0000111 "peptide" ; obo:IAO_0000115 "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "peptide" ; rdfs:subClassOf obo:CHEBI_33839 . obo:CHEBI_166899 obo:IAO_0000111 "globulin type" ; obo:IAO_0000115 "One of the major classifications of proteins, which may be further divided into the euglobulins and the pseudoglobulins. The former group is insoluble in water but soluble in saline solutions and may be precipitated in water that has been half-saturated with a salt such as ammonium sulfate. The latter group is soluble in water and has properties that resemble those of the true globulins. Globulins are an important source of protein in seed plants and are found in minute amounts in cereals. Globulins found in animal fluids are enzymes, antibodies, and fibrous and contractile proteins usually contained in the blood plasma." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "globulin type" ; rdfs:subClassOf obo:CHEBI_33839 . obo:CHEBI_16737 obo:IAO_0000111 "creatinine" ; obo:IAO_0000115 "A lactam obtained by formal cyclocondensation of creatine. It is a metabolite of creatine." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "creatinine" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_168396 obo:IAO_0000111 "mycophenolic acid" ; obo:IAO_0000115 "A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mycophenolic acid" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_16919 obo:IAO_0000111 "creatine" ; obo:IAO_0000115 "A glycine derivative having methyl and amidino groups attached to the nitrogen." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "creatine" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_16990 obo:IAO_0000111 "bilirubin IXalpha" ; obo:IAO_0000115 "A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "bilirubin IXalpha" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_16991 obo:IAO_0000111 "deoxyribonucleic acid" ; obo:IAO_0000115 "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "deoxyribonucleic acid" ; rdfs:subClassOf obo:CHEBI_33696 . obo:CHEBI_17026 obo:IAO_0000111 "progesterone" ; obo:IAO_0000115 "A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "progesterone" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_17137 obo:IAO_0000111 "hydrogensulfite" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "hydrogensulfite" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_17230 obo:IAO_0000111 "homocysteine" ; obo:IAO_0000115 "A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "homocysteine" ; rdfs:subClassOf obo:CHEBI_33709 . obo:CHEBI_17234 obo:IAO_0000111 "glucose" ; obo:IAO_0000115 "An aldohexose used as a source of energy and metabolic intermediate." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "glucose" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_17347 obo:IAO_0000111 "testosterone" ; obo:IAO_0000115 "An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5.." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "testosterone" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_17423 obo:IAO_0000111 "methemoglobin" ; obo:IAO_0000115 "A hemoprotein that is the ferric (Fe(3+)) form of hemoglobin." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "methemoglobin" ; rdfs:subClassOf obo:CHEBI_33839 . obo:CHEBI_17544 obo:IAO_0000111 "hydrogencarbonate" ; obo:IAO_0000115 "The carbon oxoanion resulting from the removal of a proton from carbonic acid." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "hydrogencarbonate" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_17650 obo:IAO_0000111 "cortisol" ; obo:IAO_0000115 "A 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the \"stress hormone\" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cortisol" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_17709 obo:IAO_0000111 "5'-adenylyl sulfate" ; obo:IAO_0000115 "An adenosine 5'-phosphate having a sulfo group attached to one the phosphate OH groups." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "5'-adenylyl sulfate" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_17855 obo:IAO_0000111 "triglyceride" ; obo:IAO_0000115 "Any glyceride resulting from the condensation of all three hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "triglyceride" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_17996 obo:IAO_0000111 "chloride" ; obo:IAO_0000115 "A halide anion formed when chlorine picks up an electron to form an an anion." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chloride" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_20067 obo:IAO_0000111 "3-hydroxybutyric acid" ; obo:IAO_0000115 "A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "3-hydroxybutyric acid" ; rdfs:subClassOf obo:CHEBI_35366 . obo:CHEBI_22868 obo:IAO_0000111 "bile salt" ; obo:IAO_0000115 "A sodium salt of the conjugate of any bile acid with either glycine or taurine." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "bile salt" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_23367 obo:IAO_0000111 "molecular entity" ; obo:IAO_0000115 "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." ; obo:IAO_0000116 "We are assuming that every molecular entity has to be completely connected by chemical bonds. This excludes protein complexes, which are comprised of minimally two separate molecular entities. We will follow up with Chebi to ensure this is their understanding as well"@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "molecular entity" ; rdfs:subClassOf obo:BFO_0000040 . obo:CHEBI_23528 obo:IAO_0000111 "cytochalasin" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cytochalasin" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_23965 obo:IAO_0000111 "estradiol" ; obo:IAO_0000115 "A 3-hydroxy steroid that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "estradiol" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_23995 obo:IAO_0000111 "N-ethyl-N-nitrosourea" ; obo:IAO_0000115 "A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "N-ethyl-N-nitrosourea" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_24636 obo:IAO_0000111 "proton" ; obo:IAO_0000115 "Nuclear particle of charge number +1, spin 1/2 and rest mass of 1.007276470(12) u." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "proton" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_24875 obo:IAO_0000111 "iron cation" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "iron cation" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_25078 obo:IAO_0000111 "luciferin" ; obo:IAO_0000115 "A low-molecular-mass compound present in bioluminescent organisms that emits light when oxidized in presence of enzyme luciferase." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "luciferin" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_2637 obo:IAO_0000111 "amikacin" ; obo:IAO_0000115 "An amino cyclitol glycoside that is kanamycin A acylated at the N-1 position by a 4-amino-2-hydroxybutyryl group." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "amikacin" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_26710 obo:IAO_0000111 "sodium chloride" ; obo:IAO_0000115 "An inorganic chloride salt having sodium(1+) as the counterion." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "sodium chloride" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_27226 obo:IAO_0000111 "uric acid" ; obo:IAO_0000115 "An oxopurine that is the final oxidation product of purine metabolism." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "uric acid" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_27889 obo:IAO_0000111 "lead(0)" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "lead(0)" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_28001 obo:IAO_0000111 "vancomycin" ; obo:IAO_0000115 "A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "vancomycin" ; rdfs:subClassOf obo:CHEBI_16670 . obo:CHEBI_28358 obo:IAO_0000111 "rac-lactic acid" ; obo:IAO_0000115 "A racemate comprising equimolar amounts of (R)- and (S)-lactic acid." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "rac-lactic acid" ; rdfs:subClassOf obo:BFO_0000040 . obo:CHEBI_28619 obo:IAO_0000111 "acrylamide" ; obo:IAO_0000115 "A member of the class of acrylamides that results from the formal condensation of acrylic acid with ammonia." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "acrylamide" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_28689 obo:IAO_0000111 "dehydroepiandrosterone" ; obo:IAO_0000115 "An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "dehydroepiandrosterone" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_28774 obo:IAO_0000111 "3,3',5'-triiodothyronine" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "3,3',5'-triiodothyronine" ; rdfs:subClassOf obo:CHEBI_33709 . obo:CHEBI_28864 obo:IAO_0000111 "tobramycin" ; obo:IAO_0000115 "A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "tobramycin" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_29101 obo:IAO_0000111 "sodium(1+)" ; obo:IAO_0000115 "A monoatomic monocation obtained from sodium." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "sodium(1+)" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_29103 obo:IAO_0000111 "potassium(1+)" ; obo:IAO_0000115 "A monoatomic monocation obtained from potassium." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "potassium(1+)" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_29191 obo:IAO_0000111 "hydroxyl" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "hydroxyl" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_29237 obo:IAO_0000111 "deuterium atom" ; obo:IAO_0000115 "The stable isotope of hydrogen with relative atomic mass 2.014102 and a natural abundance of 0.0115 atom percent (from Greek deltaepsilonupsilontauepsilonrhoomicronnu, second)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "deuterium atom" ; rdfs:subClassOf obo:CHEBI_23367, obo:CHEBI_33250 . obo:CHEBI_30660 obo:IAO_0000111 "thyroxine" ; obo:IAO_0000115 "An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "thyroxine" ; rdfs:subClassOf obo:CHEBI_33709 . obo:CHEBI_30682 obo:IAO_0000111 "ruthenium atom" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ruthenium atom" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_31624 obo:IAO_0000111 "fluorescein (lactone form)" ; obo:IAO_0000115 "A xanthene dye that is highly fluorescent, detectable even when present in minute quantities. Used forensically to detect traces of blood, in analytical chemistry as an indicator in silver nitrate titrations and in microscopy." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "fluorescein (lactone form)" ; rdfs:subClassOf obo:OBI_0002744, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0002743 ] . obo:CHEBI_31642 obo:IAO_0000111 "gadodiamide hydrate" ; obo:IAO_0000115 "The hydrate of gadodiamide." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "gadodiamide hydrate" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_31643 obo:IAO_0000111 "gadoteridol" ; obo:IAO_0000115 "A non-ionic gadolinium chelate having a macrocyclic tetraamine framework. It is used as a paramagnetic contrast agent in magnetic resonance imaging (MRI)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "gadoteridol" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_31991 obo:IAO_0000111 "phenol red" ; obo:IAO_0000115 "3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 4-hydroxyphenyl groups. A pH indicator changing colour from yellow below pH 6.8 to bright pink above pH 8.2, it is commonly used as an indicator in cell cultures and in home swimming pool test kits. It is also used in the (now infrequently performed) phenolsulfonphthalein (PSP) test for estimation of overall blood flow through the kidney." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "phenol red" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_32142 obo:IAO_0000111 "sodium citrate dihydrate" ; obo:IAO_0000115 "The dihydrate of trisodium citrate." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "sodium citrate dihydrate" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_33250 obo:IAO_0000111 "atom" ; obo:IAO_0000115 "A chemical entity constituting the smallest component of an element having the chemical properties of the element." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "atom" ; rdfs:subClassOf obo:BFO_0000040 . obo:CHEBI_33262 obo:IAO_0000111 "elemental oxygen" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "elemental oxygen" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_33321 obo:IAO_0000111 "rare earth metal atom" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "rare earth metal atom" ; rdfs:subClassOf obo:CHEBI_33250 . obo:CHEBI_33359 obo:IAO_0000111 "rhodium atom" ; obo:IAO_0000115 "A cobalt group element atom of atomic number 45." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "rhodium atom" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_33375 obo:IAO_0000111 "gadolinium atom" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "gadolinium atom" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_33376 obo:IAO_0000111 "terbium atom" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "terbium atom" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_33696 obo:IAO_0000111 "nucleic acid" ; obo:IAO_0000115 "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "nucleic acid" ; rdfs:subClassOf obo:CHEBI_33839 . obo:CHEBI_33697 obo:IAO_0000111 "ribonucleic acid" ; obo:IAO_0000115 "High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ribonucleic acid" ; rdfs:subClassOf obo:CHEBI_33696 . obo:CHEBI_33709 obo:IAO_0000111 "amino acid" ; obo:IAO_0000115 "A carboxylic acid containing one or more amino groups." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "amino acid" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_33839 obo:IAO_0000111 "macromolecule" ; obo:IAO_0000115 "A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." ; obo:IAO_0000118 "polymer"@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "macromolecule" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_35143 obo:IAO_0000111 "hemoglobin" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "hemoglobin" ; rdfs:subClassOf obo:CHEBI_33839 . obo:CHEBI_35366 obo:IAO_0000111 "fatty acid" ; obo:IAO_0000115 "Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax. Natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated. By extension, the term is sometimes used to embrace all acyclic aliphatic carboxylic acids." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "fatty acid" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_35729 obo:IAO_0000111 "gadolinium molecular entity" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "gadolinium molecular entity" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_35780 obo:IAO_0000111 "phosphate ion" ; obo:IAO_0000115 "A phosphorus oxoanion that is the conjugate base of phosphoric acid." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "phosphate ion" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_37333 obo:IAO_0000111 "gadodiamide" ; obo:IAO_0000115 "A non-ionic gadolinium chelate having a macrocyclic triamine framework. It is used as a paramagnetic contrast agent in magnetic resonance imaging (MRI)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "gadodiamide" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_37445 obo:IAO_0000111 "folic acids" ; obo:IAO_0000115 "A group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid units." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "folic acids" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_37586 obo:IAO_0000111 "sodium phosphate" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "sodium phosphate" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_37972 obo:IAO_0000111 "phosphorus-32 atom" ; obo:IAO_0000115 "The radioactive isotope of phosphorus with relative atomic mass 31.973907 and half-life of 14.26 days." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "phosphorus-32 atom" ; rdfs:subClassOf obo:CHEBI_33250, obo:OBI_0001879, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0002743 ] . obo:CHEBI_37973 obo:IAO_0000111 "phosphorus-33 atom" ; obo:IAO_0000115 "The radioactive isotope of phosphorus with relative atomic mass 32.971725, half-life of 25.34 days and nuclear spin (1)/2." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "phosphorus-33 atom" ; rdfs:subClassOf obo:CHEBI_33250, obo:OBI_0001879, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0002743 ] . obo:CHEBI_37987 obo:IAO_0000111 "Cy3 dye" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Cy3 dye" ; rdfs:subClassOf obo:OBI_0002744, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0002743 ] . obo:CHEBI_37989 obo:IAO_0000111 "Cy5 dye" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Cy5 dye" ; rdfs:subClassOf obo:OBI_0002744, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0002743 ] . obo:CHEBI_39025 obo:IAO_0000111 "high-density lipoprotein" ; obo:IAO_0000115 "A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. They are synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "high-density lipoprotein" ; rdfs:subClassOf obo:CHEBI_6495 . obo:CHEBI_39026 obo:IAO_0000111 "low-density lipoprotein" ; obo:IAO_0000115 "A class of lipoproteins of small size (18-25 nm) and low density (1.019-1.063 g/ml) particles with a core composed mainly of cholesterol esters and smaller amounts of triglycerides. The surface monolayer consists mostly of phospholipids, a single copy of apolipoprotein B-100, and free cholesterol molecules. The main function of LDL is to transport cholesterol and cholesterol esters from the liver. Excessive levels are associated with cardiovascular disease." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "low-density lipoprotein" ; rdfs:subClassOf obo:CHEBI_6495 . obo:CHEBI_39027 obo:IAO_0000111 "very-low-density lipoprotein" ; obo:IAO_0000115 "A class of lipoproteins of large size (30-80 nm), very low density (0.93-1.006 g/ml) particles with a core composed mainly of triglycerides and a surface monolayer of phospholipids and cholesterol into which are imbedded the apolipoproteins B, E, and C. VLDL facilitate the transport of endogenously made triglycerides to extrahepatic tissues." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "very-low-density lipoprotein" ; rdfs:subClassOf obo:CHEBI_6495 . obo:CHEBI_39123 obo:IAO_0000111 "calcium cation" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "calcium cation" ; rdfs:subClassOf obo:CHEBI_39124 . obo:CHEBI_39124 obo:IAO_0000111 "calcium ion" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "calcium ion" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_39127 obo:IAO_0000111 "magnesium cation" ; obo:IAO_0000115 "Any magnesium ion that is positively charged." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "magnesium cation" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_39867 obo:IAO_0000111 "valproic acid" ; obo:IAO_0000115 "A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "valproic acid" ; rdfs:subClassOf obo:CHEBI_35366 . obo:CHEBI_42098 obo:IAO_0000111 "digoxigenin" ; obo:IAO_0000115 "A hydroxy steroid that consists of 5beta-cardanolide having a double bond at the 20(22)-position as well as hydroxy groups at the 3beta-, 12beta- and 14beta-positions. It has been isolated from the plant species of the genus Digitalis." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "digoxigenin" ; rdfs:subClassOf obo:OBI_0002744, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0002743 ] . obo:CHEBI_42191 obo:IAO_0000111 "ethylenediaminetetraacetic acid" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ethylenediaminetetraacetic acid" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_4551 obo:IAO_0000111 "digoxin" ; obo:IAO_0000115 "A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "digoxin" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_4705 obo:IAO_0000111 "double-stranded DNA" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "double-stranded DNA" ; rdfs:subClassOf obo:CHEBI_16991 . obo:CHEBI_472552 obo:IAO_0000111 "5-bromo-2'-deoxyuridine" ; obo:IAO_0000115 "A pyrimidine 2'-deoxyribonucleoside compound having 5-bromouracil as the nucleobase." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "5-bromo-2'-deoxyuridine" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_47774 obo:IAO_0000111 "low-density lipoprotein cholesterol" ; obo:IAO_0000115 "Cholesterol esters and free cholesterol which are contained in or bound to low-density lipoproteins (LDL)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "low-density lipoprotein cholesterol" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_47775 obo:IAO_0000111 "high-density lipoprotein cholesterol" ; obo:IAO_0000115 "Cholesterol esters and free cholesterol which are contained in or bound to high-density lipoproteins (HDL)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "high-density lipoprotein cholesterol" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_50076 obo:IAO_0000111 "chromium-51" ; obo:IAO_0000115 "A synthetic radioactive isotope of chromium having a half-life of 27.7 days and decaying by electron capture with emission of gamma rays (0.32 MeV); it is used to label red blood cells for measurement of mass or volume, survival time, and sequestration studies, for the diagnosis of gastrointestinal bleeding, and to label platelets to study their survival." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chromium-51" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_51756 obo:IAO_0000111 "Alexa Fluor 532" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Alexa Fluor 532" ; rdfs:subClassOf obo:OBI_0002744, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0002743 ] . obo:CHEBI_51760 obo:IAO_0000111 "Alexa Fluor 546" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Alexa Fluor 546" ; rdfs:subClassOf obo:OBI_0002744, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0002743 ] . obo:CHEBI_52673 obo:IAO_0000111 "Alexa Fluor 555" ; obo:IAO_0000115 "A fluorescent dye of absorption wavelength 555 nm and emission wavelength 565 nm, derived from a 3,6-diaminoxanthene-4,5-disulfate." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Alexa Fluor 555" ; rdfs:subClassOf obo:OBI_0002744, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0002743 ] . obo:CHEBI_53526 obo:IAO_0000111 "tritiated thymidine" ; obo:IAO_0000115 "Thymidine linked to the radioisotope tritium. Used to label DNA in the study of cellular and viral DNA synthesis." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "tritiated thymidine" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_59050 obo:IAO_0000111 "dimethyl sulfate" ; obo:IAO_0000115 "The dimethyl ester of sulfuric acid." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "dimethyl sulfate" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_59051 obo:IAO_0000111 "diethyl pyrocarbonate" ; obo:IAO_0000115 "The diethyl ester of dicarbonic acid." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "diethyl pyrocarbonate" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_59052 obo:IAO_0000111 "1,1-dihydroxy-3-ethoxy-2-butanone" ; obo:IAO_0000115 "A butanone derivative having two hydroxy substituents at the 1-position and an ethoxy substituent at the 3-position." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "1,1-dihydroxy-3-ethoxy-2-butanone" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_59053 obo:IAO_0000111 "N-cyclohexyl-N'-(2-(4-morpholinyl)ethyl)carbodiimide" ; obo:IAO_0000115 "A carbodiimide having cyclcohexyl and 2-(4-morpholinyl)ethyl as the two N-substituents." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "N-cyclohexyl-N'-(2-(4-morpholinyl)ethyl)carbodiimide" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_59054 obo:IAO_0000111 "N-methylisatoic anhydride" ; obo:IAO_0000115 "A 3,1-benzoxazin-1,4-dione having an N-methyl substituent." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "N-methylisatoic anhydride" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_59055 obo:IAO_0000111 "(S)-1-(4-bromoacetamidobenzyl)EDTA" ; obo:IAO_0000115 "A tetracarboxylic acid consisting of ethylenediaminetetraacetic acid having a 4-bromoacetamidobenzyl group at the C1-position and (S)-configuration." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "(S)-1-(4-bromoacetamidobenzyl)EDTA" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_59056 obo:IAO_0000111 "EDTA methidiumpropylamide" ; obo:IAO_0000115 "A combined intercalating and chelating reagent. The iron chelate, prepared by adding Fe(NH4)2(SO4)2, effects random oxidative cleavage of DNA in the presence of O2 and a reducing agent. This activity is useful as a footprinting probe." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "EDTA methidiumpropylamide" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_59424 obo:IAO_0000111 "bromophenol blue" ; obo:IAO_0000115 "3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 3,5-dibromo-4-hydroxyphenyl groups. It is used as a laboratory indicator, changing from yellow below pH 3 to purple at pH 4.6, and as a size marker for monitoring the progress of agarose gel and polyacrylamide gel electrophoresis. It has also been used as an industrial dye." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "bromophenol blue" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_61057 obo:IAO_0000111 "tacrolimus hydrate" ; obo:IAO_0000115 "A hydrate that is the monohydrate form of tacrolimus." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "tacrolimus hydrate" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_61073 obo:IAO_0000111 "oxygen radical" ; obo:IAO_0000115 "An inorganic radical in which a free electron resides on one or more oxygen atoms of an oxygen species." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "oxygen radical" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_6495 obo:IAO_0000111 "lipoprotein" ; obo:IAO_0000115 "A clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "lipoprotein" ; rdfs:subClassOf obo:CHEBI_33839 . obo:CHEBI_81567 obo:IAO_0000111 "thyroid stimulating hormone" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "thyroid stimulating hormone" ; rdfs:subClassOf obo:CHEBI_33839 . obo:CHEBI_81568 obo:IAO_0000111 "Luteinizing hormone" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Luteinizing hormone" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_81569 obo:IAO_0000111 "Follicle stimulating hormone" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Follicle stimulating hormone" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_86319 obo:IAO_0000111 "25-hydroxyvitamin D2" ; obo:IAO_0000115 "A hydroxycalciol that is vitamin D2 in which the hydrogen at position 25 has been replaced by a hydroxy group." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "25-hydroxyvitamin D2" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_9754 obo:IAO_0000111 "tris" ; obo:IAO_0000115 "A primary amino compound that is tert-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group. A compound widely used as a biological buffer substance in the pH range 7--9; pKa = 8.3 at 20 degreeC; pKa = 7.82 at 37 degreeC." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "tris" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHMO_0000087 obo:IAO_0000115 "Any type of light microscopy assay where the specimen can be made to fluoresce (emit energy as visible light) by illuminating it with light of specific wavelengths. These specimens are called fluorophores." ; obo:IAO_0000118 "FM", "fluorescence imaging", "fluorescence microscopic imaging" ; obo:IAO_0000119 "CHMO" ; a owl:Class ; rdfs:label "fluorescence microscopy assay" ; rdfs:subClassOf obo:CHMO_0000102, obo:OBI_0001501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000018 ] ) ] ] . obo:CHMO_0000089 obo:IAO_0000115 "Microscopy where the specimen can be made to fluoresce (emit energy as visible light) by scanning a gas (Ar or Kr) laser spot of specific wavelength over its surface and using a spatial pinhole to eliminate out-of-focus fluorescence." ; obo:IAO_0000118 "CLSM", "LSCM", "confocal fluorescence imaging", "confocal laser scanning fluorescence microscopy", "confocal laser scanning microscopy", "confocal-laser scanning microscopy", "fluorescence confocal microscopy", "fluorescence confocal scanning laser microscopy", "scanning confocal fluorescence microscopy" ; obo:IAO_0000119 "CHMO" ; a owl:Class ; rdfs:label "confocal fluorescence microscopy assay" ; rdfs:subClassOf obo:OBI_0002119 . obo:CHMO_0000102 obo:IAO_0000115 "Microscopy where the specimen is illuminated with visible light and a system of lenses is used to produce an image." ; obo:IAO_0000118 "OM", "light microscopy", "optical microscopy" ; obo:IAO_0000119 "CHMO" ; a owl:Class ; rdfs:label "light microscopy assay" ; rdfs:subClassOf obo:OBI_0002119 . obo:CHMO_0000701 obo:IAO_0000115 "A method where a sample mixture is first separated by liquid chromatography before being ionised and characterised by mass-to-charge ratio and relative abundance using two mass spectrometers in series." ; obo:IAO_0000118 "LC-MS-MS", "LC-MS/MS", "LC-MS2", "LC-MSMS", "LC/MS/MS", "LCMSMS", "liquid chromatography tandem mass spectrometry", "liquid chromatography tandem mass spectroscopy", "liquid chromatography-tandem mass spectroscopy" ; obo:IAO_0000119 "CHMO" ; a owl:Class ; rdfs:label "liquid chromatography-tandem mass spectrometry" ; rdfs:subClassOf obo:OBI_0003097, obo:OBI_0003540, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003547 ] . obo:CLO_0000001 obo:IAO_0000111 "cell line cell", "cell line cell"@en, "细胞系细胞"@zh ; obo:IAO_0000115 "A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture"@en, """A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture """, "一个培养细胞，它是一个细胞株（一个稳定的，同质的细胞群，具有共同的生物学起源和增殖史）的一部分", """一个培养细胞，它是一个细胞株（一个稳定的，同质的细胞群，具有共同的生物学起源和增殖史）的一部分 """ ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cell line cell", "cell line cell"@en, "细胞系细胞"@zh ; rdfs:subClassOf obo:OBI_0001866, [ a owl:Class ; owl:unionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0001867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0001867 ] ] ) ], _:genid215 . obo:CLO_0000018 obo:IAO_0000111 "mortal cell line cell", "mortal cell line cell"@en, "非永生细胞系细胞"@zh ; obo:IAO_0000115 "A cell line cell that is capable of replicating a limited number of times in culture before undergoing senescence.", "A cell line cell that is capable of replicating a limited number of times in culture before undergoing senescence."@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mortal cell line cell", "mortal cell line cell"@en, "非永生细胞系细胞"@zh ; rdfs:subClassOf obo:CLO_0000001 . obo:CLO_0000019 obo:IAO_0000111 "immortal cell line cell", "immortal cell line cell"@en, "永生细胞系细胞"@zh ; obo:IAO_0000115 "A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite propagation in vitro as part of an immortal cell line.", "A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite propagation in vitro as part of an immortal cell line."@en, "预期能够进行无限次分裂的细胞系细胞，作为永生细胞系一部分，能够支持体外无限增殖。" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "immortal cell line cell", "immortal cell line cell"@en, "永生细胞系细胞"@zh ; rdfs:subClassOf obo:CLO_0000001 . obo:CLO_0000031 obo:IAO_0000111 "cell line"@en, "细胞系"@zh ; obo:IAO_0000115 "A cultured cell population that represents a genetically stable and homogenous population of cultured cells that shares a common propagation history (i.e. has been successively passaged together in culture). "@en, """A cultured cell population that represents a genetically stable and homogenous population of cultured cells that shares a common propagation history (i.e. has been successively passaged together in culture). """, "一个培养细胞群体，其代表具有共同增殖历史（即已经在培养中一起连续传代）的遗传稳定且同质的培养细胞群体。"@zh, """培养的细胞群体代表具有共同繁殖历史（即已经在培养中一起连续传代）的遗传稳定且同质的培养细胞群体。 """ ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cell line"@en, "细胞系"@zh ; rdfs:subClassOf obo:OBI_0001905, [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:CLO_0000001 ], [ a owl:Restriction ; owl:allValuesFrom obo:CLO_0000001 ; owl:onProperty obo:OBI_0000643 ] . obo:CLO_0009828 obo:IAO_0000111 "immortal cell line"@en ; obo:IAO_0000115 "A cell line that is expected to be capable of indefinite propagation in an vitro culture." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "immortal cell line"@en ; rdfs:subClassOf obo:CLO_0000031, [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:CLO_0000019 ], [ a owl:Restriction ; owl:allValuesFrom obo:CLO_0000019 ; owl:onProperty obo:OBI_0000643 ] . obo:CLO_0009829 obo:IAO_0000111 "mortal cell line"@en ; obo:IAO_0000115 "A cell line is able to support only a limited number of passages in vitro." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mortal cell line"@en ; rdfs:subClassOf obo:CLO_0000031, [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:CLO_0000018 ], [ a owl:Restriction ; owl:allValuesFrom obo:CLO_0000018 ; owl:onProperty obo:OBI_0000643 ], [ a owl:Restriction ; owl:onClass obo:OBI_0000877 ; owl:onProperty obo:OBI_0000312 ; owl:qualifiedCardinality "0"^^xsd:nonNegativeInteger ] . obo:CL_0000000 obo:IAO_0000111 "cell" ; obo:IAO_0000112 "PMID:18089833.Cancer Res. 2007 Dec 15;67(24):12018-25. \"...Epithelial cells were harvested from histologically confirmed adenocarcinomas ..\""@en ; obo:IAO_0000115 "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cell" ; rdfs:subClassOf obo:BFO_0000040 . obo:CL_0000001 obo:IAO_0000111 "primary cultured cell" ; obo:IAO_0000115 "A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "primary cultured cell" ; rdfs:subClassOf obo:CL_0000010, [ a owl:Class ; owl:complementOf [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600037 ] ], [ a owl:Class ; owl:complementOf [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000010 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600037 ] ) ] ] ] . obo:CL_0000003 obo:IAO_0000111 "native cell" ; obo:IAO_0000115 "A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "native cell" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0000010 obo:IAO_0000111 "cultured cell" ; obo:IAO_0000115 "A cell in vitro that is or has been maintained or propagated as part of a cell culture." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cultured cell" ; rdfs:subClassOf obo:CL_0000578, [ a owl:Class ; owl:unionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600036 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600036 ] ] ) ] . obo:CL_0000057 obo:IAO_0000111 "fibroblast" ; obo:IAO_0000115 "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "fibroblast" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0000066 obo:IAO_0000111 "epithelial cell" ; obo:IAO_0000115 "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "epithelial cell" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0000077 obo:IAO_0000111 "mesothelial cell" ; obo:IAO_0000115 "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mesothelial cell" ; rdfs:subClassOf obo:CL_0000003, obo:CL_0000066 . obo:CL_0000084 obo:IAO_0000111 "T cell" ; obo:IAO_0000115 "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "T cell" ; rdfs:subClassOf obo:CL_0000542 . obo:CL_0000097 obo:IAO_0000111 "mast cell" ; obo:IAO_0000115 "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mast cell" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0000182 obo:IAO_0000111 "hepatocyte" ; obo:IAO_0000115 "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "hepatocyte" ; rdfs:subClassOf obo:CL_0000066 . obo:CL_0000232 obo:IAO_0000111 "erythrocyte" ; obo:IAO_0000115 "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "erythrocyte" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0000233 obo:IAO_0000111 "platelet" ; obo:IAO_0000115 "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "platelet" ; rdfs:subClassOf obo:CL_0000003 . obo:CL_0000235 obo:IAO_0000111 "macrophage" ; obo:IAO_0000115 "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "macrophage" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0000236 obo:IAO_0000111 "B cell" ; obo:IAO_0000115 "A lymphocyte of B lineage that is capable of B cell mediated immunity." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "B cell" ; rdfs:subClassOf obo:CL_0000542 . obo:CL_0000451 obo:IAO_0000111 "dendritic cell" ; obo:IAO_0000115 "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "dendritic cell" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0000540 obo:IAO_0000111 "neuron" ; obo:IAO_0000115 "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "neuron" ; rdfs:subClassOf obo:CL_0002319 . obo:CL_0000542 obo:IAO_0000111 "lymphocyte" ; obo:IAO_0000115 "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "lymphocyte" ; rdfs:subClassOf obo:CL_0000842 . obo:CL_0000556 obo:IAO_0000111 "megakaryocyte" ; obo:IAO_0000115 "A giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "megakaryocyte" ; rdfs:subClassOf obo:CL_0000003 . obo:CL_0000558 obo:IAO_0000111 "reticulocyte" ; obo:IAO_0000115 "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "reticulocyte" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0000560 obo:IAO_0000111 "band form neutrophil" ; obo:IAO_0000115 "A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil. These cells are fMLP receptor-positive, CD11b-positive, CD35-negative, and CD49d-negative." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "band form neutrophil" ; rdfs:subClassOf obo:CL_0000775 . obo:CL_0000562 obo:IAO_0000111 "nucleate erythrocyte" ; obo:IAO_0000115 "An erythrocyte having a nucleus." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "nucleate erythrocyte" ; rdfs:subClassOf obo:CL_0000003, obo:CL_0000232 . obo:CL_0000576 obo:IAO_0000111 "monocyte" ; obo:IAO_0000115 "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "monocyte" ; rdfs:subClassOf obo:CL_0000003, obo:CL_0000738, obo:CL_0000842 . obo:CL_0000578 obo:IAO_0000111 "experimentally modified cell in vitro" ; obo:IAO_0000115 "A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "experimentally modified cell in vitro" ; rdfs:subClassOf obo:CL_0000000, obo:OBI_0000047, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000094 ] . obo:CL_0000624 obo:IAO_0000111 "CD4-positive, alpha-beta T cell" ; obo:IAO_0000115 "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "CD4-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000789 . obo:CL_0000625 obo:IAO_0000111 "CD8-positive, alpha-beta T cell" ; obo:IAO_0000115 "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "CD8-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000789 . obo:CL_0000738 obo:IAO_0000111 "leukocyte" ; obo:IAO_0000115 "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "leukocyte" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0000767 obo:IAO_0000111 "basophil" ; obo:IAO_0000115 "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "basophil" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0000771 obo:IAO_0000111 "eosinophil" ; obo:IAO_0000115 "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "eosinophil" ; rdfs:subClassOf obo:CL_0000003, obo:CL_0000738 . obo:CL_0000775 obo:IAO_0000111 "neutrophil" ; obo:IAO_0000115 "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "neutrophil" ; rdfs:subClassOf obo:CL_0000003, obo:CL_0000738 . obo:CL_0000776 obo:IAO_0000111 "immature neutrophil" ; obo:IAO_0000115 "Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "immature neutrophil" ; rdfs:subClassOf obo:CL_0000775 . obo:CL_0000786 obo:IAO_0000111 "plasma cell" ; obo:IAO_0000115 "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "plasma cell" ; rdfs:subClassOf obo:CL_0000236 . obo:CL_0000789 obo:IAO_0000111 "alpha-beta T cell" ; obo:IAO_0000115 "A T cell that expresses an alpha-beta T cell receptor complex." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000084 . obo:CL_0000794 obo:IAO_0000111 "CD8-positive, alpha-beta cytotoxic T cell" ; obo:IAO_0000115 "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "CD8-positive, alpha-beta cytotoxic T cell" ; rdfs:subClassOf obo:CL_0000625 . obo:CL_0000814 obo:IAO_0000111 "mature NK T cell" ; obo:IAO_0000115 "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mature NK T cell" ; rdfs:subClassOf obo:CL_0000789 . obo:CL_0000836 obo:IAO_0000111 "promyelocyte" ; obo:IAO_0000115 "A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "promyelocyte" ; rdfs:subClassOf obo:CL_0000003 . obo:CL_0000842 obo:IAO_0000111 "mononuclear cell" ; obo:IAO_0000115 "A leukocyte with a single non-segmented nucleus in the mature form." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mononuclear cell" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0001064 obo:IAO_0000111 "malignant cell" ; obo:IAO_0000115 "A neoplastic cell that is capable of entering a surrounding tissue" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "malignant cell" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0002192 obo:IAO_0000111 "metamyelocyte" ; obo:IAO_0000115 "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "metamyelocyte" ; rdfs:subClassOf obo:CL_0000003 . obo:CL_0002193 obo:IAO_0000111 "myelocyte" ; obo:IAO_0000115 "A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "myelocyte" ; rdfs:subClassOf obo:CL_0000003 . obo:CL_0002319 obo:IAO_0000111 "neural cell" ; obo:IAO_0000115 "A cell that is part of the nervous system." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "neural cell" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0011114 obo:IAO_0000111 "segmented neutrophil of bone marrow" ; obo:IAO_0000115 "A segmented neutrophilic cell of the bone marrow reserve pool that expresses CD11b (integrin alpha-M) and high levels of CD16 (low affinity immunoglobulin gamma Fc region receptor III) on its cell surface." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "segmented neutrophil of bone marrow" ; rdfs:subClassOf obo:CL_0000775 . obo:CL_2000001 obo:IAO_0000111 "peripheral blood mononuclear cell" ; obo:IAO_0000115 "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "peripheral blood mononuclear cell" ; rdfs:subClassOf obo:CL_0000003, obo:CL_0000842 . obo:COB_0000080 obo:IAO_0000111 "complex of molecular entities" ; obo:IAO_0000115 "A complex of two or more molecular entities that are not covalently bound." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "complex of molecular entities" ; rdfs:subClassOf obo:BFO_0000040 . obo:ENVO_00001998 obo:IAO_0000111 "soil" ; obo:IAO_0000115 "Soil is an environmental material which is primarily composed of minerals, varying proportions of sand, silt, and clay, organic material such as humus, gases, liquids, and a broad range of resident micro- and macroorganisms." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "soil" ; rdfs:subClassOf obo:BFO_0000040 . obo:ENVO_00002257 obo:IAO_0000111 "podzol" ; obo:IAO_0000115 "Podzols are soils with a typically ash-grey upper subsurface horizon, bleached by loss of organic matter and iron oxides, on top of a dark accumulation horizon with brown, reddish or black illuviated humus and/or reddish Fe compounds. Podzols occur in humid areas in the boreal and temperate zones and locally also in the tropics." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "podzol" ; rdfs:subClassOf obo:ENVO_00001998 . obo:ENVO_00010483 obo:IAO_0000111 "environmental material" ; obo:IAO_0000115 "A portion of environmental material is a fiat object part which forms the medium or part of the medium of an environmental system." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "environmental material" ; rdfs:subClassOf obo:BFO_0000040 . obo:GAZ_00000448 obo:IAO_0000115 "A reference to a place on the Earth, by its name or by its geographical location." ; obo:IAO_0000412 ; a owl:Class, owl:NamedIndividual ; rdfs:label "geographic location" ; rdfs:subClassOf obo:BFO_0000029 . obo:GO_0000785 obo:IAO_0000111 "chromatin" ; obo:IAO_0000115 "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chromatin" ; rdfs:subClassOf obo:GO_0005575 . obo:GO_0001046 obo:IAO_0000111 "core promoter sequence-specific DNA binding" ; obo:IAO_0000115 "Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "core promoter sequence-specific DNA binding" ; rdfs:subClassOf obo:GO_0003674, obo:GO_0043565 . obo:GO_0001047 obo:IAO_0000412 ; a owl:Class ; rdfs:subClassOf obo:OBI_0001588 . obo:GO_0001172 obo:IAO_0000111 "RNA-templated transcription" ; obo:IAO_0000115 "The synthesis of an RNA transcript from an RNA template." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "RNA-templated transcription" ; rdfs:subClassOf obo:GO_0009987 . obo:GO_0001508 obo:IAO_0000111 "action potential" ; obo:IAO_0000115 "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "action potential" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0001788 obo:IAO_0000111 "antibody-dependent cellular cytotoxicity" ; obo:IAO_0000115 "Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "antibody-dependent cellular cytotoxicity" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0001806 obo:IAO_0000111 "type IV hypersensitivity" ; obo:IAO_0000115 "An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "type IV hypersensitivity" ; rdfs:subClassOf obo:GO_0002524 . obo:GO_0001816 obo:IAO_0000111 "cytokine production" ; obo:IAO_0000115 "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cytokine production" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0001906 obo:IAO_0000111 "cell killing" ; obo:IAO_0000115 "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cell killing" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0001913 obo:IAO_0000111 "T cell mediated cytotoxicity" ; obo:IAO_0000115 "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "T cell mediated cytotoxicity" ; rdfs:subClassOf obo:GO_0001906 . obo:GO_0002250 obo:IAO_0000111 "adaptive immune response" ; obo:IAO_0000115 "An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "adaptive immune response" ; rdfs:subClassOf obo:GO_0006955 . obo:GO_0002367 obo:IAO_0000111 "cytokine production involved in immune response" ; obo:IAO_0000115 "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cytokine production involved in immune response" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0002390 obo:IAO_0000412 ; a owl:Class ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0002507 obo:IAO_0000111 "tolerance induction" ; obo:IAO_0000115 "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "tolerance induction" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0002514 obo:IAO_0000111 "B cell tolerance induction" ; obo:IAO_0000115 "A process involving any mechanism for tolerance induction in B cells." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "B cell tolerance induction" ; rdfs:subClassOf obo:GO_0002507 . obo:GO_0002517 obo:IAO_0000111 "T cell tolerance induction" ; obo:IAO_0000115 "A process involving any mechanism for tolerance induction in T cells." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "T cell tolerance induction" ; rdfs:subClassOf obo:GO_0002507 . obo:GO_0002524 obo:IAO_0000111 "hypersensitivity" ; obo:IAO_0000115 "An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "hypersensitivity" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0002534 obo:IAO_0000111 "cytokine production involved in inflammatory response" ; obo:IAO_0000115 "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cytokine production involved in inflammatory response" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0003094 obo:IAO_0000111 "glomerular filtration" ; obo:IAO_0000115 "The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "glomerular filtration" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0003674 obo:IAO_0000111 "molecular_function" ; obo:IAO_0000115 "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "molecular_function" ; rdfs:subClassOf obo:BFO_0000015 . obo:GO_0003823 obo:IAO_0000111 "antigen binding" ; obo:IAO_0000115 "Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "antigen binding" ; rdfs:subClassOf obo:GO_0003674 . obo:GO_0003824 obo:IAO_0000111 "catalytic activity" ; obo:IAO_0000115 "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "catalytic activity" ; rdfs:subClassOf obo:GO_0003674 . obo:GO_0003939 obo:IAO_0000111 "L-iditol 2-dehydrogenase activity" ; obo:IAO_0000115 "Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "L-iditol 2-dehydrogenase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0003964 obo:IAO_0000111 "RNA-directed DNA polymerase activity" ; obo:IAO_0000115 "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "RNA-directed DNA polymerase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0003990 obo:IAO_0000111 "acetylcholinesterase activity" ; obo:IAO_0000115 "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "acetylcholinesterase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0003997 obo:IAO_0000111 "acyl-CoA oxidase activity" ; obo:IAO_0000115 "Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "acyl-CoA oxidase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0004021 obo:IAO_0000111 "L-alanine:2-oxoglutarate aminotransferase activity" ; obo:IAO_0000115 "Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "L-alanine:2-oxoglutarate aminotransferase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0004035 obo:IAO_0000111 "alkaline phosphatase activity" ; obo:IAO_0000115 "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "alkaline phosphatase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0004069 obo:IAO_0000111 "L-aspartate:2-oxoglutarate aminotransferase activity" ; obo:IAO_0000115 "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "L-aspartate:2-oxoglutarate aminotransferase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0004104 obo:IAO_0000111 "cholinesterase activity" ; obo:IAO_0000115 "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cholinesterase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0004111 obo:IAO_0000111 "creatine kinase activity" ; obo:IAO_0000115 "Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "creatine kinase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0004353 obo:IAO_0000111 "glutamate dehydrogenase [NAD(P)+] activity" ; obo:IAO_0000115 "Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "glutamate dehydrogenase [NAD(P)+] activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0004364 obo:IAO_0000111 "glutathione transferase activity" ; obo:IAO_0000115 "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "glutathione transferase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0004448 obo:IAO_0000111 "isocitrate dehydrogenase [NAD(P)+] activity" ; obo:IAO_0000115 "Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "isocitrate dehydrogenase [NAD(P)+] activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0004457 obo:IAO_0000111 "lactate dehydrogenase activity" ; obo:IAO_0000115 "Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "lactate dehydrogenase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0004540 obo:IAO_0000111 "ribonuclease activity" ; obo:IAO_0000115 "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ribonuclease activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0005216 obo:IAO_0000111 "ion channel activity" ; obo:IAO_0000115 "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ion channel activity" ; rdfs:subClassOf obo:GO_0009987 . obo:GO_0005575 obo:IAO_0000111 "cellular_component" ; obo:IAO_0000115 "A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cellular_component" ; rdfs:subClassOf obo:BFO_0000040 . obo:GO_0005577 obo:IAO_0000111 "fibrinogen complex" ; obo:IAO_0000115 "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "fibrinogen complex" ; rdfs:subClassOf obo:GO_0032991 . obo:GO_0005694 obo:IAO_0000111 "chromosome" ; obo:IAO_0000115 "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chromosome" ; rdfs:subClassOf obo:GO_0005575 . obo:GO_0005739 obo:IAO_0000111 "mitochondrion" ; obo:IAO_0000115 "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mitochondrion" ; rdfs:subClassOf obo:GO_0043227 . obo:GO_0006006 obo:IAO_0000111 "glucose metabolic process" ; obo:IAO_0000115 "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "glucose metabolic process" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0006260 obo:IAO_0000111 "DNA replication" ; obo:IAO_0000115 "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "DNA replication" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0006306 obo:IAO_0000111 "DNA methylation" ; obo:IAO_0000115 "The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "DNA methylation" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0006338 obo:IAO_0000111 "chromatin remodeling" ; obo:IAO_0000115 "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chromatin remodeling" ; rdfs:subClassOf obo:GO_0009987 . obo:GO_0006909 obo:IAO_0000111 "phagocytosis" ; obo:IAO_0000115 "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "phagocytosis" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0006955 obo:IAO_0000111 "immune response" ; obo:IAO_0000115 "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "immune response" ; rdfs:subClassOf obo:GO_0050896 . obo:GO_0006974 obo:IAO_0000111 "cellular response to DNA damage stimulus" ; obo:IAO_0000115 "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cellular response to DNA damage stimulus" ; rdfs:subClassOf obo:GO_0050896 . obo:GO_0007049 obo:IAO_0000111 "cell cycle" ; obo:IAO_0000115 "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cell cycle" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0007596 obo:IAO_0000111 "blood coagulation" ; obo:IAO_0000115 "The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "blood coagulation" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0008150 obo:IAO_0000111 "biological_process" ; obo:IAO_0000115 "A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "biological_process" ; rdfs:subClassOf obo:BFO_0000015 ; owl:disjointWith obo:OBI_0000011 . obo:GO_0008228 obo:IAO_0000111 "opsonization" ; obo:IAO_0000115 "The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "opsonization" ; rdfs:subClassOf obo:GO_0006909 . obo:GO_0008253 obo:IAO_0000111 "5'-nucleotidase activity" ; obo:IAO_0000115 "Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "5'-nucleotidase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0008283 obo:IAO_0000111 "cell population proliferation" ; obo:IAO_0000115 "The multiplication or reproduction of cells, resulting in the expansion of a cell population." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cell population proliferation" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0009566 obo:IAO_0000111 "fertilization" ; obo:IAO_0000115 "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "fertilization" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0009987 obo:IAO_0000111 "cellular process" ; obo:IAO_0000115 "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cellular process" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0010467 obo:IAO_0000111 "gene expression" ; obo:IAO_0000115 "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "gene expression" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0010573 obo:IAO_0000111 "vascular endothelial growth factor production" ; obo:IAO_0000115 "The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "vascular endothelial growth factor production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0015925 obo:IAO_0000111 "galactosidase activity" ; obo:IAO_0000115 "Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "galactosidase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0016064 obo:IAO_0000111 "immunoglobulin mediated immune response" ; obo:IAO_0000115 "An immune response mediated by immunoglobulins, whether cell-bound or in solution." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "immunoglobulin mediated immune response" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0016160 obo:IAO_0000111 "amylase activity" ; obo:IAO_0000115 "Catalysis of the hydrolysis of amylose or an amylose derivative." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "amylase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0016231 obo:IAO_0000111 "beta-N-acetylglucosaminidase activity" ; obo:IAO_0000115 "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "beta-N-acetylglucosaminidase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0016570 obo:IAO_0000111 "histone modification" ; obo:IAO_0000115 "The covalent alteration of one or more amino acid residues within a histone protein." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "histone modification" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0016788 obo:IAO_0000111 "hydrolase activity, acting on ester bonds" ; obo:IAO_0000115 "Catalysis of the hydrolysis of any ester bond." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "hydrolase activity, acting on ester bonds" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0019814 obo:IAO_0000111 "immunoglobulin complex" ; obo:IAO_0000115 "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "immunoglobulin complex" ; rdfs:subClassOf obo:GO_0032991 . obo:GO_0019815 obo:IAO_0000111 "B cell receptor complex" ; obo:IAO_0000115 "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "B cell receptor complex" ; rdfs:subClassOf obo:OBI_1110022 . obo:GO_0019882 obo:IAO_0000111 "antigen processing and presentation" ; obo:IAO_0000115 "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "antigen processing and presentation" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0019904 obo:IAO_0000111 "protein domain specific binding" ; obo:IAO_0000115 "Binding to a specific domain of a protein." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "protein domain specific binding" ; rdfs:subClassOf obo:OBI_0001588 . obo:GO_0030041 obo:IAO_0000111 "actin filament polymerization" ; obo:IAO_0000115 "Assembly of actin filaments by the addition of actin monomers to a filament." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "actin filament polymerization" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0030097 obo:IAO_0000111 "hemopoiesis" ; obo:IAO_0000115 "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "hemopoiesis" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0032601 obo:IAO_0000111 "connective tissue growth factor production" ; obo:IAO_0000115 "The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "connective tissue growth factor production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032602 obo:IAO_0000111 "chemokine production" ; obo:IAO_0000115 "The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chemokine production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032604 obo:IAO_0000111 "granulocyte macrophage colony-stimulating factor production" ; obo:IAO_0000115 "The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "granulocyte macrophage colony-stimulating factor production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032605 obo:IAO_0000111 "hepatocyte growth factor production" ; obo:IAO_0000115 "The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "hepatocyte growth factor production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032606 obo:IAO_0000111 "type I interferon production" ; obo:IAO_0000115 "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "type I interferon production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032607 obo:IAO_0000111 "interferon-alpha production" ; obo:IAO_0000115 "The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interferon-alpha production" ; rdfs:subClassOf obo:GO_0032606 . obo:GO_0032608 obo:IAO_0000111 "interferon-beta production" ; obo:IAO_0000115 "The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interferon-beta production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032609 obo:IAO_0000111 "interferon-gamma production" ; obo:IAO_0000115 "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interferon-gamma production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032610 obo:IAO_0000111 "interleukin-1 alpha production" ; obo:IAO_0000115 "The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-1 alpha production" ; rdfs:subClassOf obo:GO_0032612 . obo:GO_0032611 obo:IAO_0000111 "interleukin-1 beta production" ; obo:IAO_0000115 "The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-1 beta production" ; rdfs:subClassOf obo:GO_0032612 . obo:GO_0032612 obo:IAO_0000111 "interleukin-1 production" ; obo:IAO_0000115 "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-1 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032613 obo:IAO_0000111 "interleukin-10 production" ; obo:IAO_0000115 "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-10 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032614 obo:IAO_0000111 "interleukin-11 production" ; obo:IAO_0000115 "The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-11 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032615 obo:IAO_0000111 "interleukin-12 production" ; obo:IAO_0000115 "The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-12 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032616 obo:IAO_0000111 "interleukin-13 production" ; obo:IAO_0000115 "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-13 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032617 obo:IAO_0000111 "obsolete interleukin-14 production" ; obo:IAO_0000115 "OBSOLETE. The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "obsolete interleukin-14 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032618 obo:IAO_0000111 "interleukin-15 production" ; obo:IAO_0000115 "The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-15 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032619 obo:IAO_0000111 "interleukin-16 production" ; obo:IAO_0000115 "The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-16 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032620 obo:IAO_0000111 "interleukin-17 production" ; obo:IAO_0000115 "The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-17 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032621 obo:IAO_0000111 "interleukin-18 production" ; obo:IAO_0000115 "The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-18 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032622 obo:IAO_0000111 "interleukin-19 production" ; obo:IAO_0000115 "The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-19 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032623 obo:IAO_0000111 "interleukin-2 production" ; obo:IAO_0000115 "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-2 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032624 obo:IAO_0000111 "interleukin-20 production" ; obo:IAO_0000115 "The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-20 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032625 obo:IAO_0000111 "interleukin-21 production" ; obo:IAO_0000115 "The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-21 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032626 obo:IAO_0000111 "interleukin-22 production" ; obo:IAO_0000115 "The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-22 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032627 obo:IAO_0000111 "interleukin-23 production" ; obo:IAO_0000115 "The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-23 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032628 obo:IAO_0000111 "interleukin-24 production" ; obo:IAO_0000115 "The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-24 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032629 obo:IAO_0000111 "interleukin-25 production" ; obo:IAO_0000115 "The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-25 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032630 obo:IAO_0000111 "interleukin-26 production" ; obo:IAO_0000115 "The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-26 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032631 obo:IAO_0000111 "interleukin-27 production" ; obo:IAO_0000115 "The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-27 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032632 obo:IAO_0000111 "interleukin-3 production" ; obo:IAO_0000115 "The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-3 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032633 obo:IAO_0000111 "interleukin-4 production" ; obo:IAO_0000115 "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-4 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032634 obo:IAO_0000111 "interleukin-5 production" ; obo:IAO_0000115 "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-5 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032635 obo:IAO_0000111 "interleukin-6 production" ; obo:IAO_0000115 "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-6 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032636 obo:IAO_0000111 "interleukin-7 production" ; obo:IAO_0000115 "The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-7 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032637 obo:IAO_0000111 "interleukin-8 production" ; obo:IAO_0000115 "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-8 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032638 obo:IAO_0000111 "interleukin-9 production" ; obo:IAO_0000115 "The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-9 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032639 obo:IAO_0000111 "TRAIL production" ; obo:IAO_0000115 "The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "TRAIL production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032640 obo:IAO_0000111 "tumor necrosis factor production" ; obo:IAO_0000115 "The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." ; obo:IAO_0000118 "TNF alpha production" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "tumor necrosis factor production" ; rdfs:subClassOf obo:GO_0071706 . obo:GO_0032641 obo:IAO_0000111 "lymphotoxin A production" ; obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." ; obo:IAO_0000118 "TNF beta production" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "lymphotoxin A production" ; rdfs:subClassOf obo:GO_0071706 . obo:GO_0032905 obo:IAO_0000111 "transforming growth factor beta1 production" ; obo:IAO_0000115 "The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "transforming growth factor beta1 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032906 obo:IAO_0000111 "transforming growth factor beta2 production" ; obo:IAO_0000115 "The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "transforming growth factor beta2 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032907 obo:IAO_0000111 "transforming growth factor beta3 production" ; obo:IAO_0000115 "The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "transforming growth factor beta3 production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032991 obo:IAO_0000111 "protein-containing complex" ; obo:IAO_0000112 "A ribosome is a protein complex." ; obo:IAO_0000115 "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." ; obo:IAO_0000118 "protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "protein-containing complex" ; rdfs:subClassOf obo:BFO_0000040, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000000001 ] . obo:GO_0033036 obo:IAO_0000111 "macromolecule localization" ; obo:IAO_0000115 "Any process in which a macromolecule is transported to, or maintained in, a specific location." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "macromolecule localization" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0034061 obo:IAO_0000111 "DNA polymerase activity" ; obo:IAO_0000115 "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "DNA polymerase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0034343 obo:IAO_0000111 "type III interferon production" ; obo:IAO_0000115 "The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon lambda is the only member of the type III interferon found so far." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "type III interferon production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0035393 obo:IAO_0000111 "chemokine (C-X-C motif) ligand 9 production" ; obo:IAO_0000115 "The appearance of chemokine (C-X-C motif) ligand 9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chemokine (C-X-C motif) ligand 9 production" ; rdfs:subClassOf obo:GO_0032602 . obo:GO_0035397 obo:IAO_0000111 "helper T cell enhancement of adaptive immune response" ; obo:IAO_0000115 "Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "helper T cell enhancement of adaptive immune response" ; rdfs:subClassOf obo:GO_0002250 . obo:GO_0035398 obo:IAO_0000111 "helper T cell enhancement of T cell mediated immune response" ; obo:IAO_0000115 "Positive regulation of a T cell mediated immune response mediated via cytokine production by a helper T cell." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "helper T cell enhancement of T cell mediated immune response" ; rdfs:subClassOf obo:GO_0035397 . obo:GO_0035399 obo:IAO_0000111 "helper T cell enhancement of B cell mediated immune response" ; obo:IAO_0000115 "Positive regulation of a B cell mediated immune response mediated via cytokine production by a helper T cell." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "helper T cell enhancement of B cell mediated immune response" ; rdfs:subClassOf obo:GO_0035397 . obo:GO_0035746 obo:IAO_0000111 "granzyme A production" ; obo:IAO_0000115 "The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "granzyme A production" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0035944 obo:IAO_0000111 "perforin production" ; obo:IAO_0000115 "The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "perforin production" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0036262 obo:IAO_0000111 "granulysin production" ; obo:IAO_0000115 "The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "granulysin production" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0036392 obo:IAO_0000111 "chemokine (C-C motif) ligand 20 production" ; obo:IAO_0000115 "The appearance of chemokine (C-C motif) ligand 20 (CCL20) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chemokine (C-C motif) ligand 20 production" ; rdfs:subClassOf obo:GO_0032602 . obo:GO_0042098 obo:IAO_0000111 "T cell proliferation" ; obo:IAO_0000115 "The expansion of a T cell population by cell division. Follows T cell activation." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "T cell proliferation" ; rdfs:subClassOf obo:GO_0008283 . obo:GO_0042101 obo:IAO_0000111 "T cell receptor complex" ; obo:IAO_0000115 "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "T cell receptor complex" ; rdfs:subClassOf obo:OBI_1110022 . obo:GO_0042110 obo:IAO_0000111 "T cell activation" ; obo:IAO_0000115 "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "T cell activation" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0042571 obo:IAO_0000111 "immunoglobulin complex, circulating" ; obo:IAO_0000115 "An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component." ; obo:IAO_0000118 "antibody" ; obo:IAO_0000412 ; obo:OBI_9991118 "antibody" ; a owl:Class ; rdfs:label "immunoglobulin complex, circulating" ; rdfs:subClassOf obo:GO_0019814, obo:OBI_1110022 . obo:GO_0042575 obo:IAO_0000111 "DNA polymerase complex" ; obo:IAO_0000115 "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "DNA polymerase complex" ; rdfs:subClassOf obo:GO_0032991, obo:OBI_0000427, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom [ a owl:Restriction ; owl:allValuesFrom obo:GO_0034061 ; owl:onProperty obo:BFO_0000054 ] ] . obo:GO_0042605 obo:IAO_0000111 "peptide antigen binding" ; obo:IAO_0000115 "Binding to an antigen peptide." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "peptide antigen binding" ; rdfs:subClassOf obo:GO_0003823 . obo:GO_0042611 obo:IAO_0000111 "MHC protein complex" ; obo:IAO_0000115 "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." ; obo:IAO_0000412 , ; a owl:Class ; rdfs:label "MHC protein complex" ; rdfs:subClassOf obo:GO_0032991 . obo:GO_0043227 obo:IAO_0000111 "membrane-bounded organelle" ; obo:IAO_0000115 "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "membrane-bounded organelle" ; rdfs:subClassOf obo:GO_0005575 . obo:GO_0043316 obo:IAO_0000111 "cytotoxic T cell degranulation" ; obo:IAO_0000115 "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cytotoxic T cell degranulation" ; rdfs:subClassOf obo:GO_0001906 . obo:GO_0043565 obo:IAO_0000111 "sequence-specific DNA binding" ; obo:IAO_0000115 "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "sequence-specific DNA binding" ; rdfs:subClassOf obo:OBI_0001588 . obo:GO_0044030 obo:IAO_0000111 "regulation of DNA methylation" ; obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "regulation of DNA methylation" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0044807 obo:IAO_0000111 "macrophage migration inhibitory factor production" ; obo:IAO_0000115 "The appearance of macrophage migration inhibitory factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "macrophage migration inhibitory factor production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0044808 obo:IAO_0000111 "oncostatin M production" ; obo:IAO_0000115 "The appearance of oncostatin M due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "oncostatin M production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0044809 obo:IAO_0000111 "chemokine (C-C motif) ligand 17 production" ; obo:IAO_0000115 "The appearance of chemokine (C-C motif) ligand 17 (CCL17) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chemokine (C-C motif) ligand 17 production" ; rdfs:subClassOf obo:GO_0032602 . obo:GO_0047823 obo:IAO_0000111 "D-glutamyltransferase activity" ; obo:IAO_0000115 "Catalysis of the reaction: L(or D)-glutamine + D-glutamyl-peptide = NH3 + 5-glutamyl-D-glutamyl-peptide." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "D-glutamyltransferase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0048869 obo:IAO_0000111 "cellular developmental process" ; obo:IAO_0000115 "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cellular developmental process" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0050896 obo:IAO_0000111 "response to stimulus" ; obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "response to stimulus" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0051276 obo:IAO_0000111 "chromosome organization" ; obo:IAO_0000115 "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chromosome organization" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0052689 obo:IAO_0000111 "carboxylic ester hydrolase activity" ; obo:IAO_0000115 "Catalysis of the hydrolysis of a carboxylic ester bond." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "carboxylic ester hydrolase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0070288 obo:IAO_0000111 "ferritin complex" ; obo:IAO_0000115 "A protein complex that binds iron and acts as a major iron storage system. Intracellular and extracellular ferritin complexes have different ratios of two types of ferritin monomer, the L (light) chain and H (heavy) chain." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ferritin complex" ; rdfs:subClassOf obo:GO_0032991 . obo:GO_0070358 obo:IAO_0000111 "actin polymerization-dependent cell motility" ; obo:IAO_0000115 "A process involved in the controlled movement of a bacterial cell powered by the continuous polymerization of actin at one pole of the cell." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "actin polymerization-dependent cell motility" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0071604 obo:IAO_0000111 "transforming growth factor beta production" ; obo:IAO_0000115 "The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "transforming growth factor beta production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0071605 obo:IAO_0000111 "monocyte chemotactic protein-1 production" ; obo:IAO_0000115 "The appearance of monocyte chemotactic protein-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "monocyte chemotactic protein-1 production" ; rdfs:subClassOf obo:GO_0032602 . obo:GO_0071606 obo:IAO_0000111 "chemokine (C-C motif) ligand 4 production" ; obo:IAO_0000115 "The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chemokine (C-C motif) ligand 4 production" ; rdfs:subClassOf obo:GO_0032602 . obo:GO_0071607 obo:IAO_0000111 "macrophage inflammatory protein-1 gamma production" ; obo:IAO_0000115 "The appearance of macrophage inflammatory protein-1 gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "macrophage inflammatory protein-1 gamma production" ; rdfs:subClassOf obo:GO_0032602 . obo:GO_0071608 obo:IAO_0000111 "macrophage inflammatory protein-1 alpha production" ; obo:IAO_0000115 "The appearance of macrophage inflammatory protein 1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "macrophage inflammatory protein-1 alpha production" ; rdfs:subClassOf obo:GO_0032602 . obo:GO_0071609 obo:IAO_0000111 "chemokine (C-C motif) ligand 5 production" ; obo:IAO_0000115 "The appearance of chemokine (C-C motif) ligand 5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chemokine (C-C motif) ligand 5 production" ; rdfs:subClassOf obo:GO_0032602 . obo:GO_0071610 obo:IAO_0000111 "chemokine (C-C motif) ligand 1 production" ; obo:IAO_0000115 "The appearance of chemokine (C-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chemokine (C-C motif) ligand 1 production" ; rdfs:subClassOf obo:GO_0032602 . obo:GO_0071611 obo:IAO_0000111 "granulocyte colony-stimulating factor production" ; obo:IAO_0000115 "The appearance of granulocyte colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "granulocyte colony-stimulating factor production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0071612 obo:IAO_0000111 "IP-10 production" ; obo:IAO_0000115 "The appearance of IP-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "IP-10 production" ; rdfs:subClassOf obo:GO_0032602 . obo:GO_0071613 obo:IAO_0000111 "granzyme B production" ; obo:IAO_0000115 "The appearance of granzyme B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "granzyme B production" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0071706 obo:IAO_0000111 "tumor necrosis factor superfamily cytokine production" ; obo:IAO_0000115 "The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "tumor necrosis factor superfamily cytokine production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0071735 obo:IAO_0000111 "IgG immunoglobulin complex" ; obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "IgG immunoglobulin complex" ; rdfs:subClassOf obo:GO_0019814 . obo:GO_0071742 obo:IAO_0000111 "IgE immunoglobulin complex" ; obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "IgE immunoglobulin complex" ; rdfs:subClassOf obo:GO_0019814 . obo:GO_0071745 obo:IAO_0000111 "IgA immunoglobulin complex" ; obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "IgA immunoglobulin complex" ; rdfs:subClassOf obo:GO_0019814 . obo:GO_0071753 obo:IAO_0000111 "IgM immunoglobulin complex" ; obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "IgM immunoglobulin complex" ; rdfs:subClassOf obo:GO_0019814 . obo:GO_0071924 obo:IAO_0000111 "chemokine (C-C motif) ligand 22 production" ; obo:IAO_0000115 "The appearance of chemokine (C-C motif) ligand 22 (CCL22) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chemokine (C-C motif) ligand 22 production" ; rdfs:subClassOf obo:GO_0032602 . obo:GO_0072535 obo:IAO_0000111 "tumor necrosis factor (ligand) superfamily member 11 production" ; obo:IAO_0000115 "The appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "tumor necrosis factor (ligand) superfamily member 11 production" ; rdfs:subClassOf obo:GO_0071706 . obo:GO_0097087 obo:IAO_0000111 "interleukin-17A production" ; obo:IAO_0000115 "The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-17A production" ; rdfs:subClassOf obo:GO_0032620 . obo:GO_0097088 obo:IAO_0000111 "interleukin-17F production" ; obo:IAO_0000115 "The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "interleukin-17F production" ; rdfs:subClassOf obo:GO_0032620 . obo:GO_0097278 obo:IAO_0000111 "complement-dependent cytotoxicity" ; obo:IAO_0000115 "Cell killing caused by the membrane attack complex formed following complement activation." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "complement-dependent cytotoxicity" ; rdfs:subClassOf obo:GO_0001906 . obo:GO_0097280 obo:IAO_0000111 "histamine secretion mediated by immunoglobulin" ; obo:IAO_0000115 "Histamine release triggered by the binding of an antigen to an immunoglobulin bound to the cell surface." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "histamine secretion mediated by immunoglobulin" ; rdfs:subClassOf obo:GO_0006955 . obo:GO_0097281 obo:IAO_0000111 "immune complex formation" ; obo:IAO_0000115 "The process that gives rise to an immune complex. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. Examples are the clumping of cells such as bacteria or red blood cells in the presence of an antibody, precipitation of a toxin after an antibody binds to it, and clumping of viral particles as a result of antibody binding to the virus." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "immune complex formation" ; rdfs:subClassOf obo:GO_0016064 . obo:GO_0097282 obo:IAO_0000111 "immunoglobulin-mediated neutralization" ; obo:IAO_0000115 "The inhibition of an antigen's biological effects by antibody binding to it. An example is neutralization of diphtheria toxin by preventing its entry into human cells via the binding of antibody specific for diphtheria toxin." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "immunoglobulin-mediated neutralization" ; rdfs:subClassOf obo:GO_0016064 . obo:GO_0097388 obo:IAO_0000111 "chemokine (C-C motif) ligand 19 production" ; obo:IAO_0000115 "The appearance of chemokine (C-C motif) ligand 19 (CCL19) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chemokine (C-C motif) ligand 19 production" ; rdfs:subClassOf obo:GO_0032602 . obo:GO_0097389 obo:IAO_0000111 "chemokine (C-C motif) ligand 21 production" ; obo:IAO_0000115 "The appearance of chemokine (C-C motif) ligand 21 (CCL21) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chemokine (C-C motif) ligand 21 production" ; rdfs:subClassOf obo:GO_0032602 . obo:GO_0097390 obo:IAO_0000111 "chemokine (C-X-C motif) ligand 12 production" ; obo:IAO_0000115 "The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chemokine (C-X-C motif) ligand 12 production" ; rdfs:subClassOf obo:GO_0032602 . obo:GO_0097391 obo:IAO_0000111 "chemokine (C-X-C motif) ligand 13 production" ; obo:IAO_0000115 "The appearance of chemokine (C-X-C motif) ligand 13 (CXCL13) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chemokine (C-X-C motif) ligand 13 production" ; rdfs:subClassOf obo:GO_0032602 . obo:GO_0097392 obo:IAO_0000111 "chemokine (C-X-C motif) ligand 16 production" ; obo:IAO_0000115 "The appearance of chemokine (C-X-C motif) ligand 16 (CXCL16) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chemokine (C-X-C motif) ligand 16 production" ; rdfs:subClassOf obo:GO_0032602 . obo:GO_0140730 obo:IAO_0000111 "amphiregulin production" ; obo:IAO_0000115 "The appearance of amphiregulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "amphiregulin production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0140779 obo:IAO_0000111 "XCL1 production" ; obo:IAO_0000115 "The appearance of XCL1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "XCL1 production" ; rdfs:subClassOf obo:GO_0001816 . obo:HP_0000855 obo:IAO_0000111 "Insulin resistance" ; obo:IAO_0000115 "Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Insulin resistance" ; rdfs:subClassOf obo:BFO_0000016 . obo:HP_0002664 obo:IAO_0000111 "Neoplasm" ; obo:IAO_0000115 "An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Neoplasm" ; rdfs:subClassOf obo:UBERON_0000465 . obo:IAO_0000001 obo:IAO_0000111 "conditional specification"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A directive information entity that specifies what should happen if the trigger condition is fulfilled."@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en, "OBI_0000349"@en ; a owl:Class ; rdfs:label "conditional specification"@en ; rdfs:subClassOf obo:IAO_0000033 . obo:IAO_0000002 obo:IAO_0000111 "example to be eventually removed"@en ; a obo:IAO_0000078, owl:NamedIndividual ; rdfs:label "example to be eventually removed"@en . obo:IAO_0000003 obo:IAO_0000111 "measurement unit label"@en ; obo:IAO_0000112 "Examples of measurement unit labels are liters, inches, weight per volume."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A measurement unit label is as a label that is part of a scalar measurement datum and denotes a unit of measure."@en ; obo:IAO_0000116 """2009-03-16: provenance: a term measurement unit was proposed for OBI (OBI_0000176) , edited by Chris Stoeckert and Cristian Cocos, and subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definition of this, different, term."""@en, "2009-03-16: review of this term done during during the OBI workshop winter 2009 and the current definition was considered acceptable for use in OBI. If there is a need to modify this definition please notify OBI."@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Melanie Courtot"@en ; a owl:Class ; rdfs:label "measurement unit label"@en ; rdfs:subClassOf obo:IAO_0000009 . obo:IAO_0000004 a owl:DatatypeProperty, owl:FunctionalProperty ; rdfs:domain obo:IAO_0000032 ; rdfs:label "has measurement value"@en ; rdfs:range xsd:double . obo:IAO_0000005 obo:IAO_0000111 "objective specification"@en ; obo:IAO_0000112 "In the protocol of a ChIP assay the objective specification says to identify protein and DNA interaction."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved."@en ; obo:IAO_0000116 "2009-03-16: original definition when imported from OBI read: \"objective is an non realizable information entity which can serve as that proper part of a plan towards which the realization of the plan is directed.\""@en, "2014-03-31: In the example of usage (\"In the protocol of a ChIP assay the objective specification says to identify protein and DNA interaction\") there is a protocol which is the ChIP assay protocol. In addition to being concretized on paper, the protocol can be concretized as a realizable entity, such as a plan that inheres in a person. The objective specification is the part that says that some protein and DNA interactions are identified. This is a specification of a process endpoint: the boundary in the process before which they are not identified and after which they are. During the realization of the plan, the goal is to get to the point of having the interactions, and participants in the realization of the plan try to do that."@en, "Answers the question, why did you do this experiment?"@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Barry Smith"@en, "PERSON: Bjoern Peters"@en, "PERSON: Jennifer Fostel"@en ; obo:IAO_0000118 "goal specification"@en ; obo:IAO_0000119 "OBI Plan and Planned Process/Roles Branch"@en, "OBI_0000217"@en ; a owl:Class ; rdfs:label "objective specification"@en ; rdfs:subClassOf obo:IAO_0000033 . obo:IAO_0000006 obo:IAO_0000111 "narrative object"@en ; obo:IAO_0000112 "Examples of narrative objects are reports, journal articles, and patents submission."@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A narrative object is an information content entity that is a set of propositions."@en ; obo:IAO_0000116 "2009-08-10 Alan Ruttenberg: Larry Hunter suggests that this be obsoleted and replaced by 'textual entity' and 'figure'. Alan restored as there are OBI dependencies and this merits further discussion"@en, "agree - DENRIE. Issue(alan) do we only mean text? What about a story told by mime. Does music count? (no) what about an oral report. Regarding definition, saying it is a set of propositions means we loose the idea that wording matters. Maybe adjust saying a narrative object has some relationshop to a set of propositions"@en ; obo:IAO_0000117 "person:Chris Stoeckert"@en ; obo:IAO_0000119 "OBI_0000013"@en, "group:OBI"@en ; a owl:Class ; rdfs:label "narrative object"@en ; rdfs:subClassOf obo:IAO_0000030 . obo:IAO_0000007 obo:IAO_0000112 "Pour the contents of flask 1 into flask 2"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A directive information entity that describes an action the bearer will take."@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; obo:IAO_0000119 "OBI Plan and Planned Process branch"@en ; a owl:Class ; rdfs:label "action specification"@en ; rdfs:subClassOf obo:IAO_0000033 . obo:IAO_0000008 obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_artifact" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:IAO_0000009 obo:IAO_0000111 "datum label"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A label is a symbol that is part of some other datum and is used to either partially define the denotation of that datum or to provide a means for identifying the datum as a member of the set of data with the same label"@en ; obo:IAO_0000116 "http://www.golovchenko.org/cgi-bin/wnsearch?q=label#4n"@en ; obo:IAO_0000117 "GROUP: IAO"@en ; obo:IAO_0000232 """9/22/11 BP: changed the rdfs:label for this class from 'label' to 'datum label' to convey that this class is not intended to cover all kinds of labels (stickers, radiolabels, etc.), and not even all kind of textual labels, but rather the kind of labels occuring in a datum. """ ; a owl:Class ; rdfs:label "datum label"@en ; rdfs:subClassOf obo:IAO_0000030 . obo:IAO_0000010 obo:IAO_0000111 "software"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 """Software is a plan specification composed of a series of instructions that can be interpreted by or directly executed by a processing unit."""@en ; obo:IAO_0000116 "see sourceforge tracker discussion at http://sourceforge.net/tracker/index.php?func=detail&aid=1958818&group_id=177891&atid=886178"@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Bjoern Peters"@en, "PERSON: Chris Stoeckert"@en, "PERSON: Melanie Courtot"@en ; obo:IAO_0000119 "GROUP: OBI"@en ; a owl:Class ; rdfs:label "software"@en ; rdfs:subClassOf obo:IAO_0000104 . obo:IAO_0000012 obo:IAO_0000111 "obsolete_digital entity"@en ; obo:IAO_0000115 "A digital entity is an information entity which is a collection of bits that can be interpreted by a computer. Two digital entities are the same if they are bitwise identical."@en ; obo:IAO_0000116 """3/22/2009 Alan Ruttenberg, obsoleted per http://groups.google.com/group/information-ontology/browse_thread/thread/789ad4b7708d5cf4 Superclass was 'digitial quality'"""@en ; obo:IAO_0000117 "person:Chris Stoeckert"@en ; obo:IAO_0000119 "OBI_0000261", "group:OBI"@en ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete2_digital entity"@en ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:IAO_0000013 obo:IAO_0000111 "journal article"@en ; obo:IAO_0000112 "Examples are articles published in the journals, Nature and Science. The content can often be cited by reference to a paper based encoding, e.g. Authors, Title of article, Journal name, date or year of publication, volume and page number."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A report that is published in a journal."@en ; obo:IAO_0000117 "person:Alan Ruttenberg"@en, "person:Chris Stoeckert"@en ; obo:IAO_0000119 "OBI_0000159"@en, "group:OBI"@en ; a owl:Class ; rdfs:label "journal article"@en ; rdfs:subClassOf obo:IAO_0000088 . obo:IAO_0000015 obo:IAO_0000111 "information carrier"@en ; obo:IAO_0000112 "In the case of a printed paperback novel the physicality of the ink and of the paper form part of the information bearer. The qualities of appearing black and having a certain pattern for the ink and appearing white for the paper form part of the information carrier in this case."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A quality of an information bearer that imparts the information content"@en ; obo:IAO_0000116 "12/15/09: There is a concern that some ways that carry information may be processes rather than qualities, such as in a 'delayed wave carrier'."@en, "2014-03-10: We are not certain that all information carriers are qualities. There was a discussion of dropping it." ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en ; obo:IAO_0000119 "Smith, Ceusters, Ruttenberg, 2000 years of philosophy"@en ; a owl:Class ; rdfs:label "information carrier"@en ; rdfs:subClassOf obo:BFO_0000019 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:BFO_0000019 [ a owl:Restriction ; owl:onProperty obo:RO_0000059 ; owl:someValuesFrom obo:IAO_0000030 ] ) ] . obo:IAO_0000017 obo:IAO_0000111 "model number"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A model number is an information content entity specifically borne by catalogs, design specifications, advertising materials, inventory systems and similar that is about manufactured objects of the same class. The model number is an alternative term for the class. The manufactered objects may or may not also bear the model number. Model numbers can be encoded in a variety of other information objects, such as bar codes, numerals, or patterns of dots."@en ; obo:IAO_0000116 "manufactered items may have more than one model number, sometimes by rebranding, or because companies are sold and the products issued new model numbers"@en ; obo:IAO_0000117 "Person: Alan Ruttenberg"@en ; a owl:Class ; rdfs:label "model number"@en ; rdfs:subClassOf obo:IAO_0000028 . obo:IAO_0000018 obo:IAO_0000231 obo:IAO_0000226 ; a owl:Class ; rdfs:label "obsolete_material_entity" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:IAO_0000019 obo:IAO_0000111 "binary digital entity"@en ; obo:IAO_0000112 "MS Word document, ZIP file, DICOM file, JPEG file"@en ; obo:IAO_0000115 "A binary digital entity is a digital entity that is encoded in a way that is not easily human readable and that contains other than text characters."@en ; obo:IAO_0000116 """3/22/2009 Alan Ruttenberg, obsoleted per http://groups.google.com/group/information-ontology/browse_thread/thread/789ad4b7708d5cf4 Superclass was 'digital entity'"""@en, "digital_entity"@en ; obo:IAO_0000117 "person:Chris Stoeckert"@en ; obo:IAO_0000119 "OBI_0000244", "group:OBI"@en ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete2_binary digital entity"@en ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:IAO_0000024 obo:IAO_0000112 "The length of a ruler." ; obo:IAO_0000115 "a unit of measure is the quality of some material entity compared to which another quality is some multiple of." ; obo:IAO_0000117 "Alan Ruttenberg" ; obo:IAO_0000119 "Smith, Ceusters, Ruttenberg, 2000 years of philosophy" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_unit of measure" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:IAO_0000025 obo:IAO_0000111 "programming language"@en ; obo:IAO_0000112 "R, Perl, Java"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A language in which source code is written that is intended to be executed/run by a software interpreter. Programming languages are ways to write instructions that specify what to do, and sometimes, how to do it."@en ; obo:IAO_0000117 "person:Alan Ruttenberg"@en, "person:Chris Stoeckert"@en ; obo:IAO_0000119 "OBI_0000058"@en, "group:OBI"@en ; a owl:Class ; rdfs:label "programming language"@en ; rdfs:subClassOf obo:IAO_0000104 . obo:IAO_0000027 obo:IAO_0000111 "data item"@en ; obo:IAO_0000112 "Data items include counts of things, analyte concentrations, and statistical summaries."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements."@en ; obo:IAO_0000116 "2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers."@en, "2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum."@en, "2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym."@en, "2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/", """JAR: datum -- well, this will be very tricky to define, but maybe some information-like stuff that might be put into a computer and that is meant, by someone, to denote and/or to be interpreted by some process... I would include lists, tables, sentences... I think I might defer to Barry, or to Brian Cantwell Smith JAR: A data item is an approximately justified approximately true approximate belief"""@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Chris Stoeckert"@en, "PERSON: Jonathan Rees"@en ; obo:IAO_0000118 "data"@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "data item"@en ; rdfs:subClassOf obo:IAO_0000030 . obo:IAO_0000028 obo:IAO_0000111 "symbol"@en ; obo:IAO_0000112 "a serial number such as \"12324X\""@en, "a stop sign"@en, "a written proper name such as \"OBI\""@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity."@en ; obo:IAO_0000116 "20091104, MC: this needs work and will most probably change"@en, "2014-03-31: We would like to have a deeper analysis of 'mark' and 'sign' in the future (see https://github.com/information-artifact-ontology/IAO/issues/154)."@en ; obo:IAO_0000117 "PERSON: James A. Overton"@en, "PERSON: Jonathan Rees"@en ; obo:IAO_0000119 "based on Oxford English Dictionary"@en ; a owl:Class ; rdfs:label "symbol"@en ; rdfs:subClassOf obo:IAO_0000030 . obo:IAO_0000029 obo:IAO_0000111 "numeral"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A symbol that denotes a number."@en ; obo:IAO_0000117 "PERSON: Jonathan Rees"@en ; a owl:Class ; rdfs:label "numeral"@en ; rdfs:subClassOf obo:IAO_0000028 . obo:IAO_0000030 obo:IAO_0000111 "information content entity"@en ; obo:IAO_0000112 "Examples of information content entites include journal articles, data, graphical layouts, and graphs."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A generically dependent continuant that is about some thing."@en ; obo:IAO_0000116 "2014-03-10: The use of \"thing\" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ)."@en, """information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907). Previous. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity."""@en ; obo:IAO_0000117 "PERSON: Chris Stoeckert"@en ; obo:IAO_0000119 "OBI_0000142"@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "information content entity"@en ; rdfs:subClassOf obo:BFO_0000031, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:BFO_0000001 ] . obo:IAO_0000031 obo:IAO_0000111 "integer numeral"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A numeral that denotes an integer"@en ; obo:IAO_0000117 "PERSON: Jonathan Rees"@en ; a owl:Class ; rdfs:label "integer numeral"@en ; rdfs:subClassOf obo:IAO_0000029 . obo:IAO_0000032 obo:IAO_0000112 "10 feet. 3 ml."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A scalar measurement datum is a measurement datum that is composed of two parts, numerals and a unit label."@en ; obo:IAO_0000116 """2009-03-16: we decided to keep datum singular in scalar measurement datum, as in this case we explicitly refer to the singular form"""@en, "Would write this as: has_part some 'measurement unit label' and has_part some numeral and has_part exactly 2, except for the fact that this won't let us take advantage of OWL reasoning over the numbers. Instead use has measurment value property to represent the same. Use has measurement unit label (subproperty of has_part) so we can easily say that there is only one of them."@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Melanie Courtot"@en ; a owl:Class ; rdfs:label "scalar measurement datum"@en ; rdfs:subClassOf obo:IAO_0000109, [ a owl:Restriction ; owl:onProperty obo:OBI_0001938 ; owl:someValuesFrom obo:OBI_0001931 ], [ a owl:Restriction ; owl:minCardinality "1"^^xsd:nonNegativeInteger ; owl:onProperty obo:IAO_0000039 ], [ a owl:Restriction ; owl:minCardinality "1"^^xsd:nonNegativeInteger ; owl:onProperty obo:IAO_0000004 ] . obo:IAO_0000033 obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An information content entity whose concretizations indicate to their bearer how to realize them in a process."@en ; obo:IAO_0000116 "2009-03-16: provenance: a term realizable information entity was proposed for OBI (OBI_0000337) , edited by the PlanAndPlannedProcess branch. Original definition was \"is the specification of a process that can be concretized and realized by an actor\" with alternative term \"instruction\".It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term."@en, "2013-05-30 Alan Ruttenberg: What differentiates a directive information entity from an information concretization is that it can have concretizations that are either qualities or realizable entities. The concretizations that are realizable entities are created when an individual chooses to take up the direction, i.e. has the intention to (try to) realize it."@en, "8/6/2009 Alan Ruttenberg: Changed label from \"information entity about a realizable\" after discussions at ICBO"@en, "Werner pushed back on calling it realizable information entity as it isn't realizable. However this name isn't right either. An example would be a recipe. The realizable entity would be a plan, but the information entity isn't about the plan, it, once concretized, *is* the plan. -Alan"@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Bjoern Peters"@en ; a owl:Class ; rdfs:label "directive information entity"@en ; rdfs:subClassOf obo:IAO_0000030, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:BFO_0000017 ] . obo:IAO_0000034 obo:IAO_0000111 "time trigger"@en ; obo:IAO_0000114 obo:IAO_0000124 ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; a owl:Class ; rdfs:label "time trigger"@en ; rdfs:subClassOf obo:IAO_0000001 . obo:IAO_0000035 obo:IAO_0000111 "obsolete_study interpretation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A study interpretation is a textual entity about the implications of a study result. Examples include discussion of whether a hypothesis is false, whether the study failed to address the hypothesis, and whether the study results have led to new hypotheses"@en ; obo:IAO_0000116 "2009-03-16: definition was \"A conclusion is a narrative object which can be published in a paper summerizing and interpreting a protocol application.\"", "2009-03-16: work has been done on this term during during the OBI workshop winter 2009 and the current definition was considered acceptable for use in OBI. If there is a need to modify this definition please notify OBI.", "The obsoleting of narrative object required a modest change in the definition of this term. Circularity with \"interpretation... interprets\" has been removed, using \"about the implications\" instead."@en ; obo:IAO_0000117 "Lawrence Hunter"@en, "PERSON: Alan Ruttenberg", "PERSON: Jennifer Fostel"@en, "PERSON: Melanie Courtot" ; obo:IAO_0000118 "conclusion" ; obo:IAO_0000119 "OBI_0000005" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_study interpretation"@en ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:IAO_0000037 obo:IAO_0000111 "dot plot"@en ; obo:IAO_0000112 "Dot plot of SSC-H and FSC-H."@en ; obo:IAO_0000114 obo:IAO_0000002 ; obo:IAO_0000115 "A dot plot is a report graph which is a graphical representation of data where each data point is represented by a single dot placed on coordinates corresponding to data point values in particular dimensions."@en ; obo:IAO_0000117 "person:Allyson Lister"@en, "person:Chris Stoeckert"@en ; obo:IAO_0000119 "OBI_0000123"@en, "group:OBI"@en ; a owl:Class ; rdfs:label "dot plot"@en ; rdfs:subClassOf obo:IAO_0000038 . obo:IAO_0000038 obo:IAO_0000111 "graph"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A diagram that presents one or more tuples of information by mapping those tuples in to a two dimensional space in a non arbitrary way."@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en, "person:Alan Ruttenberg"@en, "person:Allyson Lister"@en ; obo:IAO_0000119 "OBI_0000240"@en, "group:OBI"@en ; a owl:Class ; rdfs:label "graph"@en ; rdfs:subClassOf obo:IAO_0000309 . obo:IAO_0000039 a owl:FunctionalProperty, owl:ObjectProperty ; rdfs:label "has measurement unit label"@en ; rdfs:range obo:IAO_0000003 ; rdfs:subPropertyOf obo:BFO_0000051 . obo:IAO_0000047 obo:IAO_0000111 "text based digital entity"@en ; obo:IAO_0000112 "XML file, C++ source code file"@en ; obo:IAO_0000115 "A text based digital entity is a digital entity that is encoded so that it only contains text characters."@en ; obo:IAO_0000116 """3/22/2009 Alan Ruttenberg, obsoleted per http://groups.google.com/group/information-ontology/browse_thread/thread/789ad4b7708d5cf4 superclass was 'digital document'"""@en, "digital_entity"@en ; obo:IAO_0000117 "person:Chris Stoeckert"@en ; obo:IAO_0000119 "OBI_0000132", "group:OBI" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete2_text based digital entity"@en ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:IAO_0000055 obo:IAO_0000111 "rule"@en ; obo:IAO_0000112 "example to be added"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A rule is an executable which guides, defines, restricts actions."@en ; obo:IAO_0000116 "MSI"@en ; obo:IAO_0000117 "PRS"@en ; obo:IAO_0000119 "OBI_0500021"@en, "PRS"@en ; a owl:Class ; rdfs:label "rule"@en ; rdfs:subClassOf obo:IAO_0000001 . obo:IAO_0000057 obo:IAO_0000111 "contour plot"@en ; obo:IAO_0000112 "Contour plot of SSC-H, FSC-H, and FL1-H."@en ; obo:IAO_0000114 obo:IAO_0000002 ; obo:IAO_0000116 "generically_dependent_continuants"@en ; obo:IAO_0000117 "person:Allyson Lister"@en, "person:Chris Stoeckert"@en ; obo:IAO_0000119 "OBI_0000246"@en, "group:Flow Cytometry community"@en ; a owl:Class ; rdfs:label "contour plot"@en ; rdfs:subClassOf obo:IAO_0000038 . obo:IAO_0000059 obo:IAO_0000111 "report figure"@en ; obo:IAO_0000114 obo:IAO_0000124 ; obo:IAO_0000115 "A report figure is a report display element that has some aspect of illustration, but may be a composite of figures, images, and other elements"@en ; obo:IAO_0000116 "I prepended the 'report ' to make it clear that we mean parts of reports here. We may want a more generic version of 'figure', in which case this would become a defined class - figure and part_of some report"@en, "Replaced by defined version of figure"@en ; obo:IAO_0000117 "person:Alan Ruttenberg"@en, "person:Allyson Lister"@en ; obo:IAO_0000119 "OBI_0000027", "group:OBI"@en ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete2_report figure"@en ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:IAO_0000064 obo:IAO_0000111 "algorithm"@en ; obo:IAO_0000112 "PMID: 18378114.Genomics. 2008 Mar 28. LINKGEN: A new algorithm to process data in genetic linkage studies."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A plan specification which describes the inputs and output of mathematical functions as well as workflow of execution for achieving an predefined objective. Algorithms are realized usually by means of implementation as computer programs for execution by automata."@en ; obo:IAO_0000117 "Philippe Rocca-Serra"@en, "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI_0000270"@en, "adapted from discussion on OBI list (Matthew Pocock, Christian Cocos, Alan Ruttenberg)"@en ; a owl:Class ; rdfs:label "algorithm"@en ; rdfs:subClassOf obo:IAO_0000104 . obo:IAO_0000065 obo:IAO_0000111 "software interpreter"@en ; obo:IAO_0000112 "R program, Perl interpreter, Java virtual machine"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A software interpreter is a software application that executes some specified input software."@en ; obo:IAO_0000116 "Do we care? Jennifer: Yes, there was a particular version of R that had a bug and it was fixed later. That would imply that we mean specific version of an interpreter. So an instance of this would be a particular version of the interpreter"@en ; obo:IAO_0000117 "person:Alan Ruttenberg"@en, "person:Chris Stoeckert"@en ; obo:IAO_0000119 "OBI_0000199"@en, "group:OBI"@en ; a owl:Class ; rdfs:label "software interpreter"@en ; rdfs:subClassOf obo:IAO_0000064 . obo:IAO_0000078 obo:IAO_0000111 "curation status specification"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en ; obo:IAO_0000116 "Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)"@en ; obo:IAO_0000117 "PERSON:Bill Bug"@en ; obo:IAO_0000119 "GROUP:OBI:"@en, "OBI_0000266"@en ; a owl:Class ; rdfs:label "curation status specification"@en ; rdfs:subClassOf obo:IAO_0000102 ; owl:equivalentClass [ a owl:Class ; owl:oneOf (obo:IAO_0000002 obo:IAO_0000120 obo:IAO_0000121 obo:IAO_0000122 obo:IAO_0000123 obo:IAO_0000124 obo:IAO_0000125 obo:IAO_0000423 obo:IAO_0000428 ) ] . obo:IAO_0000079 obo:IAO_0000111 "density plot"@en ; obo:IAO_0000112 "Density plot of SSC-H and FSC-H."@en ; obo:IAO_0000114 obo:IAO_0000002 ; obo:IAO_0000115 "A density plot is a report graph which is a graphical representation of data where the tint of a particular pixel corresponds to some kind of function corresponding the the amount of data points relativelly with their distance from the the pixel."@en ; obo:IAO_0000117 "person:Allyson Lister"@en, "person:Chris Stoeckert"@en ; obo:IAO_0000119 "OBI_0000179"@en, "group:Flow Cytometry community"@en ; a owl:Class ; rdfs:label "density plot"@en ; rdfs:subClassOf obo:IAO_0000038 . obo:IAO_0000088 obo:IAO_0000111 "report"@en ; obo:IAO_0000112 "Examples of reports are gene lists and investigation reports. These are not published (journal) articles but may be included in a journal article."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A document assembled by an author for the purpose of providing information for the audience. A report is the output of a documenting process and has the objective to be consumed by a specific audience. Topic of the report is on something that has completed. A report is not a single figure. Examples of reports are journal article, patent application, grant progress report, case report (not patient record)."@en ; obo:IAO_0000116 """2009-03-16: comment from Darren Natale: I am slightly uneasy with the sentence \"Topic of the report is on something that has completed.\" Should it be restricted to those things that are completed? For example, a progress report is (usually) about something that definitely has *not* been completed, or may include (only) projections. I think the definition would not suffer if the whole sentence is deleted."""@en, "2009-03-16: this was report of results with definition: A report is a narrative object that is a formal statement of the results of an investigation, or of any matter on which definite information is required, made by some person or body instructed or required to do so."@en, "2009-03-16: work has been done on this term during during the OBI workshop winter 2009 and the current definition was considered acceptable for use in OBI. If there is a need to modify this definition please notify OBI."@en, "2009-08-10 Alan Ruttenberg: Larry Hunter suggests that this be obsoleted and replaced by 'document'. Alan restored as there are OBI dependencies and this merits further discussion"@en, "disagreement about where reports go. alan: only some gene lists are reports. Is a report all the content of some document? The example of usage suggests that a report may be part of some article. Term needs clarification"@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Melanie Courtot"@en, "PERSON:Chris Stoeckert"@en ; obo:IAO_0000119 "GROUP: OBI"@en, "OBI_0000099"@en ; a owl:Class ; rdfs:label "report"@en ; rdfs:subClassOf obo:IAO_0000310 . obo:IAO_0000091 obo:IAO_0000111 "report element"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A report element is a narrative object in which information is presented and consumed by a human being, and is part of a report. Examples of report elements are figure (dot plot), table, text portion (may include a movie or audio clip on a web page)."@en ; obo:IAO_0000116 "2009-03-16: needs some more work (clarify relations).", "2009-03-16: was report display element with definition: A report display element is a narrative object that is part of a report. Report display elements are set off from the textual parts of a report and are typically given a label(e.g. Figure 2) which is used to refer to the element from the text. Typically the 2d layout is part of the identity of such elements.", "2009-03-16: work has been done on this term during during the OBI workshop winter 2009 and the current definition was considered acceptable for use in OBI. If there is a need to modify this definition please notify OBI.", "2009-08-10 Alan Ruttenberg: Larry Hunter suggests that this be obsoleted and replaced by 'textual entity' and 'figure'. Alan restored as there are OBI dependencies and this merits further discussion", "Replaced by textual entity and figure", "There will be some issue here about whether these are defined classes. As intended these are meant to denote the parts of the report that are not textual but are typically boxed and set within the text, labelled with some identifier, and referred to in the text"@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Allyson Lister"@en, "PERSON: Melanie Courtot" ; obo:IAO_0000119 "GROUP:OBI"@en, "OBI_0000001" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_report element"@en ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:IAO_0000093 obo:IAO_0000111 "binary executable"@en ; obo:IAO_0000115 "Binary executable is a digital entity consisting of the binary representation of machine instructions of a specific processor or they may be binary pseudocode for a virtual machine. A non-source executable file is also called an object program. It is assumed that the binary executable file contains properly-formatted computer instructions. (derived from Wikipedia, Nov 1, 2007)"@en ; obo:IAO_0000116 """3/22/2009 Alan Ruttenberg, obsoleted per http://groups.google.com/group/information-ontology/browse_thread/thread/789ad4b7708d5cf4 superclass was 'digital entity'"""@en ; obo:IAO_0000117 "person:Jennifer Fostel"@en ; obo:IAO_0000119 "OBI_0000222", "group:OBI"@en ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete2_binary executable"@en ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:IAO_0000096 obo:IAO_0000111 "source code module"@en ; obo:IAO_0000112 "The written source code that implements part of an algorithm. Test - if you know that it was written in a specific language, then it can be source code module. We mean here, roughly, the wording of a document such as a perl script."@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A source code module is a directive information entity that specifies, using a programming language, some algorithm."@en ; obo:IAO_0000117 "person:Alan Ruttenberg"@en, "person:Chris Stoeckert"@en ; obo:IAO_0000119 "OBI_0000039"@en, "group:OBI"@en ; a owl:Class ; rdfs:label "source code module"@en ; rdfs:subClassOf obo:IAO_0000033 . obo:IAO_0000097 obo:IAO_0000111 "report table"@en ; obo:IAO_0000114 obo:IAO_0000002 ; obo:IAO_0000115 "A report table is a report display element consisting of a matrix of cells layed out in a grid, some set of which are filled with some information content"@en ; obo:IAO_0000116 "2009-08-10 Alan Ruttenberg: Larry Hunter suggests that this be obsoleted and replaced by 'textual entity table'. Alan restored as there are OBI dependencies and this merits further discussion" ; obo:IAO_0000117 "person:Alan Ruttenberg"@en, "person:Allyson Lister"@en ; obo:IAO_0000119 "OBI_0000265", "group:OBI"@en ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_report table"@en ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:IAO_0000098 obo:IAO_0000111 "data format specification"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 """A data format specification is the information content borne by the document published defining the specification. Example: The ISO document specifying what encompasses an XML document; The instructions in a XSD file"""@en ; obo:IAO_0000116 """2009-03-16: provenance: term imported from OBI_0000187, which had original definition \"A data format specification is a plan which organizes information. Example: The ISO document specifying what encompasses an XML document; The instructions in a XSD file\""""@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en, "OBI_0000187"@en ; a owl:Class ; rdfs:label "data format specification"@en ; rdfs:subClassOf obo:IAO_0000033 . obo:IAO_0000100 obo:IAO_0000111 "data set"@en ; obo:IAO_0000112 "Intensity values in a CEL file or from multiple CEL files comprise a data set (as opposed to the CEL files themselves)."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A data item that is an aggregate of other data items of the same type that have something in common. Averages and distributions can be determined for data sets."@en ; obo:IAO_0000116 "2009/10/23 Alan Ruttenberg. The intention is that this term represent collections of like data. So this isn't for, e.g. the whole contents of a cel file, which includes parameters, metadata etc. This is more like java arrays of a certain rather specific type"@en, "2014-05-05: Data sets are aggregates and thus must include two or more data items. We have chosen not to add logical axioms to make this restriction." ; obo:IAO_0000117 "person:Allyson Lister"@en, "person:Chris Stoeckert"@en ; obo:IAO_0000119 "OBI_0000042"@en, "group:OBI"@en ; a owl:Class ; rdfs:label "data set"@en ; rdfs:subClassOf obo:IAO_0000027 . obo:IAO_0000101 obo:IAO_0000111 "image"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An image is an affine projection to a two dimensional surface, of measurements of some quality of an entity or entities repeated at regular intervals across a spatial range, where the measurements are represented as color and luminosity on the projected on surface."@en ; obo:IAO_0000117 "person:Alan Ruttenberg"@en, "person:Allyson"@en, "person:Chris Stoeckert"@en ; obo:IAO_0000119 "OBI_0000030"@en, "group:OBI"@en ; a owl:Class ; rdfs:label "image"@en ; rdfs:subClassOf obo:IAO_0000308 . obo:IAO_0000102 obo:IAO_0000111 "data about an ontology part"@en ; obo:IAO_0000115 "Data about an ontology part is a data item about a part of an ontology, for example a term"@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en ; a owl:Class ; rdfs:label "data about an ontology part"@en ; rdfs:subClassOf obo:IAO_0000027 . obo:IAO_0000103 obo:IAO_0000111 "failed exploratory term"@en ; obo:IAO_0000115 "The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job"@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en ; a obo:IAO_0000225, owl:NamedIndividual, owl:Thing ; rdfs:label "failed exploratory term"@en . obo:IAO_0000104 obo:IAO_0000111 "plan specification"@en ; obo:IAO_0000112 "PMID: 18323827.Nat Med. 2008 Mar;14(3):226.New plan proposed to help resolve conflicting medical advice."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A directive information entity with action specifications and objective specifications as parts that, when concretized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified."@en ; obo:IAO_0000116 "2009-03-16: provenance: a term a plan was proposed for OBI (OBI_0000344) , edited by the PlanAndPlannedProcess branch. Original definition was \" a plan is a specification of a process that is realized by an actor to achieve the objective specified as part of the plan\". It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term."@en, "2014-03-31: A plan specification can have other parts, such as conditional specifications."@en, "Alternative previous definition: a plan is a set of instructions that specify how an objective should be achieved"@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; obo:IAO_0000119 "OBI Plan and Planned Process branch"@en, "OBI_0000344"@en ; a owl:Class ; rdfs:comment """2/3/2009 Comment from OBI review. Action specification not well enough specified. Conditional specification not well enough specified. Question whether all plan specifications have objective specifications. Request that IAO either clarify these or change definitions not to use them"""@en ; rdfs:label "plan specification"@en ; rdfs:subClassOf obo:IAO_0000033, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000005 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000007 ] . obo:IAO_0000105 obo:IAO_0000111 "digital document"@en ; obo:IAO_0000115 "A digital document is a digital entity consisting of an electronic file which can be rendered into human-readable form by one or more computational applications. The digital document does not refer to the information content of the document but to an instance of the file."@en ; obo:IAO_0000116 """3/22/2009 Alan Ruttenberg, obsoleted per http://groups.google.com/group/information-ontology/browse_thread/thread/789ad4b7708d5cf4 superclass was 'digial entity'"""@en ; obo:IAO_0000117 "person:Jennifer Fostel"@en ; obo:IAO_0000119 "OBI_0000195", "group:OBI"@en ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete2_digital document"@en ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:IAO_0000109 obo:IAO_0000111 "measurement datum"@en ; obo:IAO_0000112 "Examples of measurement data are the recoding of the weight of a mouse as {40,mass,\"grams\"}, the recording of an observation of the behavior of the mouse {,process,\"agitated\"}, the recording of the expression level of a gene as measured through the process of microarray experiment {3.4,luminosity,}."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device."@en ; obo:IAO_0000116 "2/2/2009 is_specified_output of some assay?"@en ; obo:IAO_0000117 "person:Chris Stoeckert"@en ; obo:IAO_0000119 "OBI_0000305"@en, "group:OBI"@en ; a owl:Class ; rdfs:label "measurement datum"@en ; rdfs:subClassOf obo:IAO_0000027, [ a owl:Restriction ; owl:onProperty obo:OBI_0001938 ; owl:someValuesFrom obo:OBI_0001933 ] . obo:IAO_0000111 obo:IAO_0000111 "editor preferred label", "editor preferred label"@en, "editor preferred term", "editor preferred term"@en, "editor preferred term~editor preferred label" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)"@en ; obo:IAO_0000117 "PERSON:Daniel Schober"@en ; obo:IAO_0000119 "GROUP:OBI:"@en ; a owl:AnnotationProperty ; rdfs:isDefinedBy ; rdfs:label "editor preferred label", "editor preferred label"@en, "editor preferred term", "editor preferred term"@en, "editor preferred term~editor preferred label" . obo:IAO_0000112 obo:IAO_0000111 "example of usage"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold."@en ; obo:IAO_0000117 "PERSON:Daniel Schober"@en ; obo:IAO_0000119 "GROUP:OBI:"@en ; a owl:AnnotationProperty ; rdfs:isDefinedBy ; rdfs:label "example of usage"@en . obo:IAO_0000113 obo:IAO_0000111 "in branch"@en ; obo:IAO_0000115 "An annotation property indicating which module the terms belong to. This is currently experimental and not implemented yet."@en ; obo:IAO_0000117 "GROUP:OBI"@en ; obo:IAO_0000119 "OBI_0000277"@en ; a owl:AnnotationProperty ; rdfs:label "in branch"@en . obo:IAO_0000114 obo:IAO_0000111 "has curation status"@en ; obo:IAO_0000117 "PERSON:Alan Ruttenberg"@en, "PERSON:Bill Bug"@en, "PERSON:Melanie Courtot"@en ; a owl:AnnotationProperty ; rdfs:label "has curation status"@en . obo:IAO_0000115 obo:IAO_0000111 "definition", "definition"@en, "textual definition" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."@en, "The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."@en ; obo:IAO_0000116 """2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. """@en ; obo:IAO_0000117 "PERSON:Daniel Schober"@en ; obo:IAO_0000119 "GROUP:OBI:"@en ; a owl:AnnotationProperty ; rdfs:isDefinedBy ; rdfs:label "definition", "definition"@en, "textual definition" . obo:IAO_0000116 obo:IAO_0000111 "editor note"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology."@en ; obo:IAO_0000117 "PERSON:Daniel Schober"@en ; obo:IAO_0000119 "GROUP:OBI:"@en ; a owl:AnnotationProperty ; rdfs:isDefinedBy ; rdfs:label "editor note"@en . obo:IAO_0000117 obo:IAO_0000111 "term editor"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people"@en ; obo:IAO_0000116 "20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115."@en ; obo:IAO_0000117 "PERSON:Daniel Schober"@en ; obo:IAO_0000119 "GROUP:OBI:"@en ; a owl:AnnotationProperty ; rdfs:isDefinedBy ; rdfs:label "term editor"@en . obo:IAO_0000118 obo:IAO_0000111 "alternative term"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent)"@en ; obo:IAO_0000117 "PERSON:Daniel Schober"@en ; obo:IAO_0000119 "GROUP:OBI:"@en ; a owl:AnnotationProperty ; rdfs:isDefinedBy ; rdfs:label "alternative term"@en . obo:IAO_0000119 obo:IAO_0000111 "definition source"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "Formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007"@en ; obo:IAO_0000117 "PERSON:Daniel Schober"@en ; obo:IAO_0000119 "Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w"@en, "GROUP:OBI:"@en ; a owl:AnnotationProperty ; rdfs:isDefinedBy ; rdfs:label "definition source"@en . obo:IAO_0000120 obo:IAO_0000111 "metadata complete"@en ; obo:IAO_0000115 "Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete."@en ; a obo:IAO_0000078, owl:NamedIndividual, owl:Thing ; rdfs:label "metadata complete"@en . obo:IAO_0000121 obo:IAO_0000111 "organizational term"@en ; obo:IAO_0000115 "Term created to ease viewing/sort terms for development purpose, and will not be included in a release"@en ; obo:IAO_0000117 "PERSON:Alan Ruttenberg" ; a obo:IAO_0000078, owl:NamedIndividual, owl:Thing ; rdfs:label "organizational term"@en . obo:IAO_0000122 obo:IAO_0000111 "ready for release"@en ; obo:IAO_0000115 "Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking \"ready_for_release\" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed \"ready_for_release\" will also derived from a chain of ancestor classes that are also \"ready_for_release.\""@en ; a obo:IAO_0000078, owl:NamedIndividual, owl:Thing ; rdfs:label "ready for release"@en . obo:IAO_0000123 obo:IAO_0000111 "metadata incomplete"@en ; obo:IAO_0000115 "Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors."@en ; a obo:IAO_0000078, owl:NamedIndividual, owl:Thing ; rdfs:label "metadata incomplete"@en . obo:IAO_0000124 obo:IAO_0000111 "uncurated"@en ; obo:IAO_0000115 "Nothing done yet beyond assigning a unique class ID and proposing a preferred term."@en ; a obo:IAO_0000078, owl:NamedIndividual, owl:Thing ; rdfs:label "uncurated"@en . obo:IAO_0000125 obo:IAO_0000111 "pending final vetting"@en ; obo:IAO_0000115 "All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor."@en ; a obo:IAO_0000078, owl:NamedIndividual, owl:Thing ; rdfs:label "pending final vetting"@en . obo:IAO_0000128 obo:IAO_0000114 obo:IAO_0000121 ; obo:IAO_0000116 """_identifier is a container under information content entity for collecting types of terms to indicate a specific instance or clas of what was used or participated in an investigation. Identifiers are borne by a product or its packaging, and can be encoded in a variety of other information objects, such as bar codes, numerals, or patterns of dots. Note: everybody agreed that identifier is probably a too general term. We however felt that it would be appropriate to group \"identifiying\" terms under some kind of umbrella. We therefore propose to use _identifier for that purpose. As per OBI conventions, the _ prefixing identifier indicates that this is a helper class and shouldn't be considered as final.""" ; obo:IAO_0000231 obo:IAO_0000226 ; a owl:Class ; rdfs:label "obsolete_identifier" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:IAO_0000129 obo:IAO_0000111 "version number"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A version number is an information content entity which is a sequence of characters borne by part of each of a class of manufactured products or its packaging and indicates its order within a set of other products having the same name."@en ; obo:IAO_0000116 "Note: we feel that at the moment we are happy with a general version number, and that we will subclass as needed in the future. For example, see 7. genome sequence version"@en ; obo:IAO_0000117 "GROUP: IAO"@en ; a owl:Class ; rdfs:label "version number"@en ; rdfs:subClassOf obo:IAO_0000028 . obo:IAO_0000131 obo:IAO_0000111 "serial number"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A serial number is an information content entity which is a unique sequence of characters borne by part of manufactured product or its packaging that is assigned to each individual in some class of products, and so can serve as a way to identify an individual product within the class. Serial numbers can be encoded in a variety of other information objects, such as bar codes, numerals, or patterns of dots."@en ; obo:IAO_0000116 "Note: during the call there was some confusion between serial number and model number. We agreed that it would be very helpful for all those terms to have example of usages - please add if you have any :-)"@en ; obo:IAO_0000117 "GROUP: IAO"@en ; a owl:Class ; rdfs:label "serial number"@en ; rdfs:subClassOf obo:IAO_0000028 . obo:IAO_0000132 obo:IAO_0000111 "lot number"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A lot number is an information content entity which is an identical sequence of character borne by part of manufactured product or its packaging for each instances of a product class in a discrete batch of an item. Lot numbers are usually assigned to each separate production run of an item. Manufacturing as a lot might be due to a variety of reasons, for example, a single process during which many individuals are made from the same portion of source material. Lot numbers can be encoded in a pattern of other information objects, such as bar codes, numerals, or patterns of dots."@en ; obo:IAO_0000117 "GROUP: IAO"@en ; obo:IAO_0000118 "batch number"@en ; a owl:Class ; rdfs:label "lot number"@en ; rdfs:subClassOf obo:IAO_0000028 . obo:IAO_0000135 obo:IAO_0000112 """The process of creation is, for example, writing down on paper the name of a friend by deliberately creating a certain pattern using ink. Here the ink + paper is the independent continuant and the carrier is the pattern in the ink. c = pattern in the ink b = paper + ink r = friend""" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 """c specifically denotes r =def r is a portion of reality & c is a particular quality & c depends specifically on some independent continuant b & b acquired c as the result of the achievement of an objective to enable pointing to r repeatedly. Marked means there is a changed or additional quality of the bearer - the quality is the information carrier. Case 1 Memory trace as mark created when reading some description of some friend. The trace can denote. Case 2 Pattern of ink arrayed on paper as mark when writing down a friend's name Case 3 Pattern of magnetic domains on scattered pieces of a hard disk platter as mark when saving a file.""" ; obo:IAO_0000116 "8/6/2009 Alan Ruttenberg: The suggestions is to deprecate specific and generically denotes in favor of a single denote relationship that corresponds to the generic sense", "see https://github.com/information-artifact-ontology/IAO/issues/25&q=denote" ; obo:IAO_0000117 "Alan Ruttenberg" ; obo:IAO_0000119 "Smith, Ceusters, Ruttenberg, 2000 years of philosophy" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:ObjectProperty ; rdfs:label "obsolete_specifically denotes" ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:IAO_0000136 obo:IAO_0000112 "This document is about information artifacts and their representations"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A (currently) primitive relation that relates an information artifact to an entity."@en ; obo:IAO_0000116 """7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of \"mentions\" relation. Weaken the is_about relationship to be primitive. We will try to build it back up by elaborating the various subproperties that are more precisely defined. Some currently missing phenomena that should be considered \"about\" are predications - \"The only person who knows the answer is sitting beside me\" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic."""@en ; obo:IAO_0000117 "person:Alan Ruttenberg"@en ; obo:IAO_0000119 "Smith, Ceusters, Ruttenberg, 2000 years of philosophy"@en ; a owl:ObjectProperty ; rdfs:domain obo:IAO_0000030 ; rdfs:label "is about"@en . obo:IAO_0000140 obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A settings datum is a datum that denotes some configuration of an instrument."@en ; obo:IAO_0000116 """2/3/2009 Feedback from OBI This should be a \"setting specification\". There is a question of whether it is information about a realizable or not. Pro other specification are about realizables. Cons sometimes specifies a quality which is not a realizable."""@en, "Alan grouped these in placeholder for the moment. Name by analogy to measurement datum."@en ; a owl:Class ; rdfs:label "setting datum"@en ; rdfs:subClassOf obo:IAO_0000027 . obo:IAO_0000141 obo:IAO_0000116 "3/22/2009 Alan Ruttenberg, obsoleted per http://groups.google.com/group/information-ontology/browse_thread/thread/789ad4b7708d5cf4", "Need to rework digital entity. Digital quality was suggested by Barry." ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_digital quality" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:IAO_0000142 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An information artifact IA mentions an entity E exactly when it has a component/part that denotes E"@en ; obo:IAO_0000116 "7/6/2009 Alan Ruttenberg. P4 RC1 munges our GCI so remove it for now: mentions some entity equivalentTo has_part some ('generically denotes' some entity)"@en, "7/6/2009 Alan Ruttenberg: Add this relation following conversation with Jonathan Rees that N&S GCI for is_about was too strong. Really it was simply sufficient. To effect this change we introduce this relation, which is subproperty of is_about, and have previous GCI use this relation \"mentions\" in it's (logical) definition"@en ; obo:IAO_0000117 "PERSON: Jonathan Rees"@en, "Person: Alan Ruttenberg"@en ; a owl:ObjectProperty ; rdfs:label "mentions"@en ; rdfs:subPropertyOf obo:IAO_0000136 . obo:IAO_0000144 obo:IAO_0000111 "conclusion textual entity"@en ; obo:IAO_0000112 "that fucoidan has a small statistically significant effect on AT3 level but no useful clinical effect as in-vivo anticoagulant, a paraphrase of part of the last paragraph of the discussion section of the paper 'Pilot clinical study to evaluate the anticoagulant activity of fucoidan', by Lowenthal et. al.PMID:19696660"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A textual entity that expresses the results of reasoning about a problem, for instance as typically found towards the end of scientific papers."@en ; obo:IAO_0000116 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case"@en, "2009/10/23 Alan Ruttenberg: We need to work on the definition still"@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en ; a owl:Class ; rdfs:label "conclusion textual entity"@en ; rdfs:subClassOf obo:IAO_0000300, obo:OBI_0001909, [ a owl:Restriction ; owl:onProperty obo:OBI_0000124 ; owl:someValuesFrom obo:IAO_0000027 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000338 ] . obo:IAO_0000178 obo:IAO_0000111 "material information bearer"@en ; obo:IAO_0000112 "A page of a paperback novel with writing on it. The paper itself is a material information bearer, the pattern of ink is the information carrier."@en, "a brain"@en, "a hard drive"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A material entity in which a concretization of an information content entity inheres."@en ; obo:IAO_0000117 "GROUP: IAO"@en ; a owl:Class ; rdfs:label "material information bearer"@en ; rdfs:subClassOf obo:BFO_0000040 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000059 ; owl:someValuesFrom obo:IAO_0000030 ] ] ) ] . obo:IAO_0000179 obo:IAO_0000111 "histogram"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 """A histogram is a report graph which is a statistical description of a distribution in terms of occurrence frequencies of different event classes."""@en ; obo:IAO_0000117 "PERSON:Chris Stoeckert"@en, "PERSON:James Malone"@en, "PERSON:Melanie Courtot"@en ; obo:IAO_0000119 "GROUP:OBI"@en ; a owl:Class ; rdfs:label "histogram"@en ; rdfs:subClassOf obo:IAO_0000038 . obo:IAO_0000180 obo:IAO_0000111 "heatmap"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 """A heatmap is a report graph which is a graphical representation of data where the values taken by a variable(s) are shown as colors in a two-dimensional map."""@en ; obo:IAO_0000117 "PERSON:Chris Stoeckert"@en, "PERSON:James Malone"@en, "PERSON:Melanie Courtot"@en ; obo:IAO_0000119 "GROUP:OBI"@en ; a owl:Class ; rdfs:label "heatmap"@en ; rdfs:subClassOf obo:IAO_0000038 . obo:IAO_0000181 obo:IAO_0000111 "Venn diagram"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 """A Venn diagram is a report graph showing all hypothetically possible logical relations between a finite collection of sets."""@en ; obo:IAO_0000117 "PERSON:Chris Stoeckert"@en, "PERSON:James Malone"@en, "PERSON:Melanie Courtot"@en ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Venn_diagram"@en ; a owl:Class ; rdfs:label "Venn diagram"@en ; rdfs:subClassOf obo:IAO_0000038 . obo:IAO_0000182 obo:IAO_0000111 "obsolete_survival curve"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A survival curve is a report graph which is a graphical representation of data where the percentage of survival is plotted as a function of time."@en ; obo:IAO_0000117 "PERSON:Chris Stoeckert"@en, "PERSON:James Malone"@en, "PERSON:Melanie Courtot"@en ; obo:IAO_0000119 "WEB: http://www.graphpad.com/www/book/survive.htm"@en ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_survival curve"@en ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:IAO_0000183 obo:IAO_0000111 "dendrogram"@en ; obo:IAO_0000112 """Dendrograms are often used in computational biology to illustrate the clustering of genes."""@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 """A dendrogram is a report graph which is a tree diagram frequently used to illustrate the arrangement of the clusters produced by a clustering algorithm."""@en ; obo:IAO_0000117 "PERSON:Chris Stoeckert"@en, "PERSON:James Malone"@en, "PERSON:Melanie Courtot"@en ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Dendrogram"@en ; a owl:Class ; rdfs:label "dendrogram"@en ; rdfs:subClassOf obo:IAO_0000038 . obo:IAO_0000184 obo:IAO_0000111 "scatter plot"@en ; obo:IAO_0000112 "Comparison of gene expression values in two samples can be displayed in a scatter plot"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A scatterplot is a graph which uses Cartesian coordinates to display values for two variables for a set of data. The data is displayed as a collection of points, each having the value of one variable determining the position on the horizontal axis and the value of the other variable determining the position on the vertical axis."@en ; obo:IAO_0000117 "PERSON:Chris Stoeckert"@en, "PERSON:James Malone"@en, "PERSON:Melanie Courtot"@en ; obo:IAO_0000118 "scattergraph"@en ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Scatterplot"@en ; a owl:Class ; rdfs:label "scatter plot"@en ; rdfs:subClassOf obo:IAO_0000038 . obo:IAO_0000185 obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A photograph is created by projecting an image onto a photosensitive surface such as a chemically treated plate or film, CCD receptor, etc."@en ; obo:IAO_0000117 "PERSON:Alan Ruttenberg"@en, "PERSON:Joanne Luciano"@en, "PERSON:Melanie Courtot"@en ; obo:IAO_0000119 "WEB: http://en.wiktionary.org/wiki/photograph"@en ; a owl:Class ; rdfs:label "photograph"@en ; rdfs:subClassOf obo:IAO_0000101 . obo:IAO_0000186 obo:IAO_0000111 "photographic print"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A photographic print is a material entity upon which a photograph generically depends."@en ; obo:IAO_0000117 "PERSON:Alan Ruttenberg"@en, "PERSON:Melanie Courtot"@en ; a owl:Class ; rdfs:label "photographic print"@en ; rdfs:subClassOf obo:IAO_0000178 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000059 ; owl:someValuesFrom obo:IAO_0000185 ] ] ) ] . obo:IAO_0000219 obo:IAO_0000112 "A person's name denotes the person. A variable name in a computer program denotes some piece of memory. Lexically equivalent strings can denote different things, for instance \"Alan\" can denote different people. In each case of use, there is a case of the denotation relation obtaining, between \"Alan\" and the person that is being named."@en ; obo:IAO_0000115 "A primitive, instance-level, relation obtaining between an information content entity and some portion of reality. Denotation is what happens when someone creates an information content entity E in order to specifically refer to something. The only relation between E and the thing is that E can be used to 'pick out' the thing. This relation connects those two together. Freedictionary.com sense 3: To signify directly; refer to specifically"@en ; obo:IAO_0000116 """2009-11-10 Alan Ruttenberg. Old definition said the following to emphasize the generic nature of this relation. We no longer have 'specifically denotes', which would have been primitive, so make this relation primitive. g denotes r =def r is a portion of reality there is some c that is a concretization of g every c that is a concretization of g specifically denotes r"""@en ; obo:IAO_0000117 "person:Alan Ruttenberg"@en ; obo:IAO_0000119 "Conversations with Barry Smith, Werner Ceusters, Bjoern Peters, Michel Dumontier, Melanie Courtot, James Malone, Bill Hogan"@en ; a owl:ObjectProperty ; rdfs:comment ""@en ; rdfs:domain obo:IAO_0000030 ; rdfs:label "denotes"@en ; rdfs:range obo:BFO_0000001 ; rdfs:subPropertyOf obo:IAO_0000136 ; owl:inverseOf obo:IAO_0000235 . obo:IAO_0000220 obo:IAO_0000116 "see https://github.com/information-artifact-ontology/IAO/issues/25&q=denote" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:ObjectProperty ; rdfs:label "obsolete_materially denotes" ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:IAO_0000221 obo:IAO_0000115 "m is a quality measurement of q at t. When q is a quality, there is a measurement process p that has specified output m, a measurement datum, that is about q"@en ; obo:IAO_0000116 "8/6/2009 Alan Ruttenberg: The strategy is to be rather specific with this relationship. There are other kinds of measurements that are not of qualities, such as those that measure time. We will add these as separate properties for the moment and see about generalizing later"@en, """From the second IAO workshop [Alan Ruttenberg 8/6/2009: not completely current, though bringing in comparison is probably important] This one is the one we are struggling with at the moment. The issue is what a measurement measures. On the one hand saying that it measures the quality would include it \"measuring\" the bearer = referring to the bearer in the measurement. However this makes comparisons of two different things not possible. On the other hand not having it inhere in the bearer, on the face of it, breaks the audit trail. Werner suggests a solution based on \"Magnitudes\" a proposal for which we are awaiting details. -- From the second IAO workshop, various comments, [commented on by Alan Ruttenberg 8/6/2009] unit of measure is a quality, e.g. the length of a ruler. [We decided to hedge on what units of measure are, instead talking about measurement unit labels, which are the information content entities that are about whatever measurement units are. For IAO we need that information entity in any case. See the term measurement unit label] [Some struggling with the various subflavors of is_about. We subsequently removed the relation represents, and describes until and only when we have a better theory] a represents b means either a denotes b or a describes describe: a describes b means a is about b and a allows an inference of at least one quality of b We have had a long discussion about denotes versus describes."""@en, """From the second IAO workshop: An attempt at tieing the quality to the measurement datum more carefully. a is a magnitude means a is a determinate quality particular inhering in some bearer b existing at a time t that can be represented/denoted by an information content entity e that has parts denoting a unit of measure, a number, and b. The unit of measure is an instance of the determinable quality."""@en, """From the second meeting on IAO: An attempt at defining assay using Barry's \"reliability\" wording assay: process and has_input some material entity and has_output some information content entity and which is such that instances of this process type reliably generate outputs that describes the input."""@en, """This one is the one we are struggling with at the moment. The issue is what a measurement measures. On the one hand saying that it measures the quality would include it \"measuring\" the bearer = referring to the bearer in the measurement. However this makes comparisons of two different things not possible. On the other hand not having it inhere in the bearer, on the face of it, breaks the audit trail. Werner suggests a solution based on \"Magnitudes\" a proposal for which we are awaiting details."""@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; a owl:ObjectProperty ; rdfs:domain obo:IAO_0000109 ; rdfs:label "is quality measurement of"@en ; rdfs:range obo:BFO_0000019 ; rdfs:subPropertyOf obo:IAO_0000136 ; owl:inverseOf obo:IAO_0000417 . obo:IAO_0000222 obo:IAO_0000231 obo:IAO_0000103 ; a owl:ObjectProperty ; rdfs:label "obsolete_describes" ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:IAO_0000223 obo:IAO_0000231 obo:IAO_0000103 ; a owl:ObjectProperty ; rdfs:label "obsolete_represents" ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:IAO_0000224 obo:IAO_0000115 "Core is an instance of a grouping of terms from an ontology or ontologies. It is used by the ontology to identify main classes."@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Melanie Courtot"@en ; obo:IAO_0000231 obo:IAO_0000226 ; a owl:NamedIndividual ; rdfs:label "obsolete_core"@en ; owl:deprecated true . obo:IAO_0000225 obo:IAO_0000111 "obsolescence reason specification"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en ; obo:IAO_0000116 "The creation of this class has been inspired in part by Werner Ceusters' paper, Applying evolutionary terminology auditing to the Gene Ontology."@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Melanie Courtot"@en ; a owl:Class ; rdfs:label "obsolescence reason specification"@en ; rdfs:subClassOf obo:IAO_0000102 ; owl:equivalentClass [ a owl:Class ; owl:oneOf (obo:IAO_0000103 obo:IAO_0000226 obo:IAO_0000227 obo:IAO_0000228 obo:IAO_0000229 ) ] . obo:IAO_0000226 obo:IAO_0000111 "placeholder removed"@en ; a obo:IAO_0000225, owl:NamedIndividual, owl:Thing ; rdfs:label "placeholder removed"@en . obo:IAO_0000227 obo:IAO_0000111 "terms merged"@en ; obo:IAO_0000116 "An editor note should explain what were the merged terms and the reason for the merge."@en ; a obo:IAO_0000225, owl:NamedIndividual ; rdfs:label "terms merged"@en . obo:IAO_0000228 obo:IAO_0000111 "term imported"@en ; obo:IAO_0000116 "This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use."@en ; a obo:IAO_0000225, owl:NamedIndividual ; rdfs:label "term imported"@en . obo:IAO_0000229 obo:IAO_0000111 "term split"@en ; obo:IAO_0000116 "This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created."@en ; a obo:IAO_0000225, owl:NamedIndividual ; rdfs:label "term split"@en . obo:IAO_0000230 obo:IAO_0000116 "This is to be used if none of the existing instances cover the reason for obsolescence. An editor note should indicate this new reason."@en, "We expect to be able to mine these new reasons and add instances as required."@en ; a owl:NamedIndividual ; rdfs:label "obsolete_other"@en ; owl:deprecated true . obo:IAO_0000231 obo:IAO_0000111 "has obsolescence reason"@en ; obo:IAO_0000115 "Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification."@en ; obo:IAO_0000117 "PERSON:Alan Ruttenberg"@en, "PERSON:Melanie Courtot"@en ; a owl:AnnotationProperty ; rdfs:label "has obsolescence reason"@en . obo:IAO_0000232 obo:IAO_0000111 "curator note"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An administrative note of use for a curator but of no use for a user"@en ; obo:IAO_0000117 "PERSON:Alan Ruttenberg"@en ; a owl:AnnotationProperty ; rdfs:isDefinedBy ; rdfs:label "curator note"@en . obo:IAO_0000233 obo:IAO_0000111 "term tracker item"@en ; obo:IAO_0000112 "the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An IRI or similar locator for a request or discussion of an ontology term."@en ; obo:IAO_0000117 "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg"@en ; obo:IAO_0000119 "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg"@en ; a owl:AnnotationProperty ; rdfs:comment "The 'tracker item' can associate a tracker with a specific ontology term."@en ; rdfs:label "term tracker item"@en . obo:IAO_0000234 obo:IAO_0000111 "ontology term requester"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "The name of the person, project, or organization that motivated inclusion of an ontology term by requesting its addition."@en ; obo:IAO_0000117 "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg"@en ; obo:IAO_0000119 "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg"@en ; a owl:AnnotationProperty ; rdfs:comment "The 'term requester' can credit the person, organization or project who request the ontology term." ; rdfs:label "ontology term requester"@en . obo:IAO_0000235 obo:IAO_0000115 "inverse of the relation 'denotes'"@en ; obo:IAO_0000117 "Person: Jie Zheng, Chris Stoeckert, Mike Conlon"@en ; obo:IAO_0000233 ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000001 ; rdfs:label "denoted by"@en ; rdfs:range obo:IAO_0000030 . obo:IAO_0000300 obo:IAO_0000111 "textual entity"@en ; obo:IAO_0000112 "Words, sentences, paragraphs, and the written (non-figure) parts of publications are all textual entities"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A textual entity is a part of a manifestation (FRBR sense), a generically dependent continuant whose concretizations are patterns of glyphs intended to be interpreted as words, formulas, etc."@en ; obo:IAO_0000116 "AR, (IAO call 2009-09-01): a document as a whole is not typically a textual entity, because it has pictures in it - rather there are parts of it that are textual entities. Examples: The title, paragraph 2 sentence 7, etc."@en, "MC, 2009-09-14 (following IAO call 2009-09-01): textual entities live at the FRBR (http://en.wikipedia.org/wiki/Functional_Requirements_for_Bibliographic_Records) manifestation level. Everything is significant: line break, pdf and html versions of same document are different textual entities."@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; obo:IAO_0000118 "text"@en ; a owl:Class ; rdfs:label "textual entity"@en ; rdfs:subClassOf obo:IAO_0000030 . obo:IAO_0000301 obo:IAO_0000111 "citation"@en ; obo:IAO_0000112 "Verspoor, K., Cohen, KB., Hunter, L. Textual characteristics of traditional and Open Access scientific journals are similar, BMC Bioinformatics 2009, 10:183."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A textual entity intended to identify a particular publication."@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "citation"@en ; rdfs:subClassOf obo:IAO_0000300, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:IAO_0000310 ] . obo:IAO_0000302 obo:IAO_0000111 "author identification"@en ; obo:IAO_0000112 "L. Hunter"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A textual entity intended to identify a particular author"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "author identification"@en ; rdfs:subClassOf obo:IAO_0000590 . obo:IAO_0000303 obo:IAO_0000111 "institutional identification"@en ; obo:IAO_0000112 "University of Colorado Denver School of Medicine"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A textual entity intended to identify a particular institution"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "institutional identification"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000304 obo:IAO_0000111 "caption"@en ; obo:IAO_0000112 "Figure 1: A system diagram describing the modules of the Hanalyzer. Reading methods (green) take external sources of knowledge (blue) and extract information from them, either by parsing structured data or biomedical language processing to extract information from unstructured data. Reading modules are responsible for tracking the provenance of all knowledge. Reasoning methods (yellow) enrich the knowledge that results from reading by, for example, noting two genes that are annotated to the same ontology term or database entry. All knowledge sources, read or reasoned, are assigned a reliability score, and all are combined using that score into a knowledge network (orange) that represents the integration of all sorts of relationship between a pair of genes and a combined reliability score. A data network (also orange) is created from experimental results to be analyzed. The reporting modules (pink) integrate the data and knowledge networks, producing visualizations that can be queried with the associated drill-down tool."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A textual entity that describes a figure"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "caption"@en ; rdfs:subClassOf obo:IAO_0000300, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:IAO_0000308 ] . obo:IAO_0000305 obo:IAO_0000111 "document title"@en ; obo:IAO_0000112 "Textual characteristics of traditional and Open Access scientific journals are similar"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A textual entity that names a document"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "document title"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000306 obo:IAO_0000111 "table"@en ; obo:IAO_0000112 """| T F --+----- T | T F F | F F"""@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A textual entity that contains a two-dimensional arrangement of texts repeated at regular intervals across a spatial range, such that the spatial relationships among the constituent texts expresses propositions"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "table"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000307 obo:IAO_0000111 "table of abbreviations"@en ; obo:IAO_0000112 """IAO information artifact ontology OBI ontology of biomedical investiations GO gene ontology"""@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A table where the constituent texts are abbreviations and their expansions"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "table of abbreviations"@en ; rdfs:subClassOf obo:IAO_0000306 . obo:IAO_0000308 obo:IAO_0000111 "figure"@en ; obo:IAO_0000112 "Any picture, diagram or table"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An information content entity consisting of a two dimensional arrangement of information content entities such that the arrangement itself is about something."@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "figure"@en ; rdfs:subClassOf obo:IAO_0000030 . obo:IAO_0000309 obo:IAO_0000111 "diagram"@en ; obo:IAO_0000112 "A molecular structure ribbon cartoon showing helices, turns and sheets and their relations to each other in space."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A figure that expresses one or more propositions"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "diagram"@en ; rdfs:subClassOf obo:IAO_0000308 . obo:IAO_0000310 obo:IAO_0000111 "document"@en ; obo:IAO_0000112 "A journal article, patent application, laboratory notebook, or a book"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A collection of information content entities intended to be understood together as a whole"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "document"@en ; rdfs:subClassOf obo:IAO_0000030 . obo:IAO_0000311 obo:IAO_0000111 "publication"@en ; obo:IAO_0000112 "A journal article or book"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A document that has been accepted by a publisher"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "publication"@en ; rdfs:subClassOf obo:IAO_0000310 . obo:IAO_0000312 obo:IAO_0000111 "publication about an investigation"@en ; obo:IAO_0000112 "Most scientific journal articles"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A publication that is about an investigation"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; obo:IAO_0000118 "scientific publication"@en ; a owl:Class ; rdfs:label "publication about an investigation"@en ; rdfs:subClassOf obo:IAO_0000311, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000066 ] . obo:IAO_0000313 obo:IAO_0000111 "patent"@en ; obo:IAO_0000112 "US Patent 6,449,603"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A document that has been accepted by a patent authority"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "patent"@en ; rdfs:subClassOf obo:IAO_0000310 . obo:IAO_0000314 obo:IAO_0000111 "document part"@en ; obo:IAO_0000112 "An abstract, introduction, method or results section."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An information content entity that is part of a document."@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "document part"@en ; rdfs:subClassOf obo:IAO_0000030, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:IAO_0000310 ] . obo:IAO_0000315 obo:IAO_0000111 "abstract"@en ; obo:IAO_0000112 "The profusion of high-throughput instruments and the explosion of new results in the scientific literature, particularly in molecular biomedicine, is both a blessing and a curse to the bench researcher. Even knowledgeable and experienced scientists can benefit from computational tools that help navigate this vast and rapidly evolving terrain. In this paper, we describe a novel computational approach to this challenge, a knowledge-based system that combines reading, reasoning and reporting methods to facilitate analysis of experimental data. Reading methods extract information from external resources, either by parsing structured data or biomedical language processing to extract information from unstructured data, and track knowledge provenance. Reasoning methods enrich the knowledge that results from reading by, for example, noting two genes that are annotated to the same ontology term or database entry. Reasoning is also used to combine all sources into a knowledge network that represents the integration of all sorts of relationships between a pair of genes, and to calculate a combined reliability score. Reporting methods combine the knowledge network with a congruent network constructed from experimental data and visualize the combined network in a tool that facilitates the knowledge-based analysis of that data."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A summary of the entire document that is substantially smaller than the document it summarizes. It is about the document it summarizes."@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "abstract"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:IAO_0000310 ] . obo:IAO_0000316 obo:IAO_0000111 "introduction to a publication about an investigation"@en ; obo:IAO_0000112 "Section labelled 'introduction' of a typical scientific journal article"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A part of a publication about an investigation that is about the objective specification (why the investigation is being done)"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; obo:IAO_0000118 "background"@en, "introduction"@en ; a owl:Class ; rdfs:label "introduction to a publication about an investigation"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:IAO_0000005 ] . obo:IAO_0000317 obo:IAO_0000111 "methods section"@en ; obo:IAO_0000112 "The section labelled 'Methods' or 'Materials and Methods' in a typical scientific journal article."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A part of a publication about an investigation that is about the study design of the investigation"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; obo:IAO_0000118 "experimental"@en, "experimental procedures"@en, "experimental section"@en, "methods"@en ; a owl:Class ; rdfs:label "methods section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0500000 ] . obo:IAO_0000318 obo:IAO_0000111 "results section"@en ; obo:IAO_0000112 "The section labelled 'results' in a typical scientific journal article"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A part of a publication about an investigation that is about a study design execution"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; obo:IAO_0000118 "results"@en ; a owl:Class ; rdfs:label "results section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000471 ] . obo:IAO_0000319 obo:IAO_0000111 "discussion section of a publication about an investigation"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A part of a publication about an investigation that is about the study interpretation of the investigation"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; obo:IAO_0000118 "discussion"@en, "discussion section"@en ; a owl:Class ; rdfs:label "discussion section of a publication about an investigation"@en ; rdfs:subClassOf obo:IAO_0000314 . obo:IAO_0000320 obo:IAO_0000111 "references section"@en ; obo:IAO_0000112 "The list of citations found at the end of a scientific publication, grant proposal or patent application, sometimes called \"literature cited\" or \"bibliography\""@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A part of a document that has citations as parts"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "references section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000301 ] . obo:IAO_0000321 obo:IAO_0000111 "author list"@en ; obo:IAO_0000112 "Lawrence Hunter and Kevin Brettonel Cohen"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A part of a document that enumerates the authors of the document"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "author list"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000302 ] . obo:IAO_0000322 obo:IAO_0000111 "institution list"@en ; obo:IAO_0000112 "The University of Colorado Denver School of Medicine and the University of Colorado Boulder."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A part of a document that has parts that are institution identifications associated with the authors of the document"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "institution list"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000303 ] . obo:IAO_0000323 obo:IAO_0000111 "author contributions section"@en ; obo:IAO_0000112 "LH conceived of the hypothesis, designed the study and contributed to the writing of the manuscript. KBC executed the experiments, analyzed the data, and contributed to the writing of the manuscript."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A part of a publication that is about the specific contributions of each author"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; obo:IAO_0000118 "author contributions"@en, "contributions by the authors"@en ; a owl:Class ; rdfs:label "author contributions section"@en ; rdfs:subClassOf obo:IAO_0000314 . obo:IAO_0000324 obo:IAO_0000111 "acknowledgements section"@en ; obo:IAO_0000112 "The authors wish to thank Alan Ruttenberg for his constructive comments about an earlier draft of this manuscript"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Part of a publication that is about the contributions of people or institutions other than the authors."@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; obo:IAO_0000118 "acknowledgements"@en, "acknowledgments"@en ; a owl:Class ; rdfs:label "acknowledgements section"@en ; rdfs:subClassOf obo:IAO_0000314 . obo:IAO_0000325 obo:IAO_0000111 "footnote"@en ; obo:IAO_0000112 "The referent in the text is usually indicated by a special typographic character such as * or a superscripted number, which is also used to indicate the footnote that refers to that text."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A part of a document that is about a specific other part of the document. Usually footnotes are spatially segregated from the rest of the document."@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; obo:IAO_0000118 "endnote"@en ; a owl:Class ; rdfs:label "footnote"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:IAO_0000314 ] . obo:IAO_0000326 obo:IAO_0000111 "supplementary material to a document"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A part of a document that is segregated from the rest of the document due to its size"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; obo:IAO_0000118 "additional information"@en, "appendix"@en, "supplemental information"@en, "supplementary material"@en, "supporting information"@en ; a owl:Class ; rdfs:label "supplementary material to a document"@en ; rdfs:subClassOf obo:IAO_0000314 . obo:IAO_0000327 obo:IAO_0000111 "table of contents"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A table that relates document parts to specific locations in a document (usually page numbers). This is also a document part (subsumption there should be inferred)."@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "table of contents"@en ; rdfs:subClassOf obo:IAO_0000306 . obo:IAO_0000328 obo:IAO_0000111 "table of figures"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A table that relates figures in a document to specific locations in that document (usually page numbers). This is also a document part (subsumption there should be inferred)."@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "table of figures"@en ; rdfs:subClassOf obo:IAO_0000306 . obo:IAO_0000329 obo:IAO_0000111 "running title"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A shorter version of a document title"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "running title"@en ; rdfs:subClassOf obo:IAO_0000305 . obo:IAO_0000330 obo:IAO_0000111 "copyright section"@en ; obo:IAO_0000112 "This work is licensed under a Creative Commons Attribution-Share Alike 3.0 United States License."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A document part that describes legal restrictions on making or distributing copies of the document"@en ; obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ; a owl:Class ; rdfs:label "copyright section"@en ; rdfs:subClassOf obo:IAO_0000314 . obo:IAO_0000400 obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cartesian spatial coordinate datum is a representation of a point in a spatial region, in which equal changes in the magnitude of a coordinate value denote length qualities with the same magnitude"@en ; obo:IAO_0000116 "2009-08-18 Alan Ruttenberg - question to BFO list about whether the BFO sense of the lower dimensional regions is that they are always part of actual space (the three dimensional sort) http://groups.google.com/group/bfo-discuss/browse_thread/thread/9d04e717e39fb617"@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; obo:IAO_0000232 "AR notes: We need to discuss whether it should include site." ; a owl:Class ; rdfs:label "cartesian spatial coordinate datum"@en ; rdfs:seeAlso "http://groups.google.com/group/bfo-discuss/browse_thread/thread/9d04e717e39fb617"@en ; rdfs:subClassOf obo:IAO_0000027, [ a owl:Restriction ; owl:onProperty obo:IAO_0000219 ; owl:someValuesFrom obo:BFO_0000018 ], [ a owl:Restriction ; owl:cardinality "1"^^xsd:nonNegativeInteger ; owl:onProperty obo:IAO_0000407 ] . obo:IAO_0000401 obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cartesion spatial coordinate datum that uses one value to specify a position along a one dimensional spatial region"@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; a owl:Class ; rdfs:label "one dimensional cartesian spatial coordinate datum"@en ; rdfs:subClassOf obo:IAO_0000400, [ a owl:Restriction ; owl:onProperty obo:IAO_0000219 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000018 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:BFO_0000026 ] ) ] ], [ a owl:Restriction ; owl:cardinality "1"^^xsd:nonNegativeInteger ; owl:onProperty obo:IAO_0000404 ] . obo:IAO_0000402 obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cartesion spatial coordinate datum that uses two values to specify a position within a two dimensional spatial region"@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; a owl:Class ; rdfs:label "two dimensional cartesian spatial coordinate datum"@en ; rdfs:subClassOf obo:IAO_0000400, [ a owl:Restriction ; owl:onProperty obo:IAO_0000219 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000018 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:BFO_0000009 ] ) ] ], [ a owl:Restriction ; owl:cardinality "1"^^xsd:nonNegativeInteger ; owl:onProperty obo:IAO_0000404 ], [ a owl:Restriction ; owl:cardinality "1"^^xsd:nonNegativeInteger ; owl:onProperty obo:IAO_0000406 ] . obo:IAO_0000403 obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cartesion spatial coordinate datum that uses three values to specify a position within a three dimensional spatial region"@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; a owl:Class ; rdfs:label "three dimensional cartesian spatial coordinate datum"@en ; rdfs:subClassOf obo:IAO_0000400, [ a owl:Restriction ; owl:onProperty obo:IAO_0000219 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000018 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:BFO_0000028 ] ) ] ], [ a owl:Restriction ; owl:cardinality "1"^^xsd:nonNegativeInteger ; owl:onProperty obo:IAO_0000404 ], [ a owl:Restriction ; owl:cardinality "1"^^xsd:nonNegativeInteger ; owl:onProperty obo:IAO_0000405 ], [ a owl:Restriction ; owl:cardinality "1"^^xsd:nonNegativeInteger ; owl:onProperty obo:IAO_0000406 ] . obo:IAO_0000404 a owl:DatatypeProperty, owl:FunctionalProperty ; rdfs:domain obo:IAO_0000400 ; rdfs:label "has x coordinate value"@en ; rdfs:range xsd:float . obo:IAO_0000405 a owl:DatatypeProperty, owl:FunctionalProperty ; rdfs:domain obo:IAO_0000400 ; rdfs:label "has z coordinate value"@en ; rdfs:range xsd:float . obo:IAO_0000406 a owl:DatatypeProperty, owl:FunctionalProperty ; rdfs:domain obo:IAO_0000400 ; rdfs:label "has y coordinate value"@en ; rdfs:range xsd:float . obo:IAO_0000407 a owl:FunctionalProperty, owl:ObjectProperty ; rdfs:comment "relating a cartesian spatial coordinate datum to a unit label that together with the values represent a point"@en ; rdfs:domain obo:IAO_0000400 ; rdfs:label "has coordinate unit label"@en ; rdfs:range obo:UO_0000001 ; rdfs:subPropertyOf obo:BFO_0000051 . obo:IAO_0000408 obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A scalar measurement datum that is the result of measurement of length quality"@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; a owl:Class ; rdfs:label "length measurement datum"@en ; rdfs:subClassOf obo:IAO_0000032, [ a owl:Restriction ; owl:onProperty obo:IAO_0000039 ; owl:someValuesFrom obo:UO_0000001 ], [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:PATO_0000122 ] . obo:IAO_0000409 obo:IAO_0000111 "denotator type"@en ; obo:IAO_0000112 "The Basic Formal Ontology ontology makes a distinction between Universals and defined classes, where the formal are \"natural kinds\" and the latter arbitrary collections of entities."@en ; obo:IAO_0000115 "A denotator type indicates how a term should be interpreted from an ontological perspective."@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; obo:IAO_0000119 "Barry Smith, Werner Ceusters"@en ; a owl:Class ; rdfs:label "denotator type"@en ; rdfs:subClassOf obo:IAO_0000102 ; owl:equivalentClass [ a owl:Class ; owl:oneOf (obo:IAO_0000410 obo:IAO_0000420 obo:IAO_0000421 ) ] . obo:IAO_0000410 obo:IAO_0000111 "universal"@en ; obo:IAO_0000116 "Hard to give a definition for. Intuitively a \"natural kind\" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents."@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; obo:IAO_0000119 "A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf"@en ; a obo:IAO_0000409, owl:NamedIndividual ; rdfs:label "universal"@en . obo:IAO_0000411 obo:IAO_0000111 "is denotator type"@en ; obo:IAO_0000115 "Relates an class defined in an ontology, to the type of it's denotator"@en ; obo:IAO_0000116 "In OWL 2 add AnnotationPropertyRange('is denotator type' 'denotator type')"@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; a owl:AnnotationProperty ; rdfs:label "is denotator type"@en . obo:IAO_0000412 obo:IAO_0000111 "imported from"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "For external terms/classes, the ontology from which the term was imported"@en ; obo:IAO_0000117 "PERSON:Alan Ruttenberg"@en, "PERSON:Melanie Courtot"@en ; obo:IAO_0000119 "GROUP:OBI:"@en ; a owl:AnnotationProperty ; rdfs:isDefinedBy ; rdfs:label "imported from"@en . obo:IAO_0000413 obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "relates a process to a time-measurement-datum that represents the duration of the process"@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en ; a owl:ObjectProperty ; rdfs:domain obo:IAO_0000416 ; rdfs:label "is duration of"@en ; rdfs:range obo:BFO_0000015 ; rdfs:subPropertyOf obo:IAO_0000136 . obo:IAO_0000414 obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A scalar measurement datum that is the result of measurement of mass quality"@en ; obo:IAO_0000116 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case"@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en ; a owl:Class ; rdfs:label "mass measurement datum"@en ; rdfs:subClassOf obo:IAO_0000032, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:allValuesFrom obo:UO_0000002 ; owl:onProperty obo:IAO_0000039 ] [ a owl:Restriction ; owl:allValuesFrom obo:PATO_0000125 ; owl:onProperty obo:IAO_0000221 ] ) ] . obo:IAO_0000415 obo:IAO_0000111 "hypothesis textual entity"@en ; obo:IAO_0000112 "that fucoidan has a small statistically significant effect on AT3 level but no useful clinical effect as in-vivo anticoagulant, a paraphrase of part of the last paragraph of the discussion section of the paper 'Pilot clinical study to evaluate the anticoagulant activity of fucoidan', by Lowenthal et. al.PMID:19696660"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A textual entity that expresses an assertion that is intended to be tested."@en ; obo:IAO_0000116 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case"@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en ; a owl:Class ; rdfs:label "hypothesis textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000416 obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A scalar measurement datum that is the result of measuring a temporal interval"@en ; obo:IAO_0000116 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case"@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en ; a owl:Class ; rdfs:label "time measurement datum"@en ; rdfs:subClassOf obo:IAO_0000032, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:allValuesFrom obo:UO_0000003 ; owl:onProperty obo:IAO_0000039 ] [ a owl:Restriction ; owl:allValuesFrom obo:BFO_0000015 ; owl:onProperty obo:IAO_0000413 ] ) ] . obo:IAO_0000417 obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "inverse of the relation of is quality measurement of"@en ; obo:IAO_0000116 "2009/10/19 Alan Ruttenberg. Named 'junk' relation useful in restrictions, but not a real instance relationship"@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en ; a owl:ObjectProperty ; rdfs:label "is quality measured as"@en . obo:IAO_0000418 obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A relation between a data item and a quality of a material entity where the material entity is the specified output of a material transformation which achieves an objective specification that indicates the intended value of the specified quality."@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en, "Person:Bjoern Peters"@en ; a owl:ObjectProperty ; rdfs:label "is quality specification of"@en ; rdfs:subPropertyOf obo:IAO_0000136 ; owl:inverseOf obo:IAO_0000419 . obo:IAO_0000419 obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "inverse of the relation of is quality specification of"@en ; obo:IAO_0000116 "2009/10/19 Alan Ruttenberg. Named 'junk' relation useful in restrictions, but not a real instance relationship"@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en, "Person:Bjoern Peters"@en ; a owl:ObjectProperty ; rdfs:label "quality is specified as"@en . obo:IAO_0000420 obo:IAO_0000111 "defined class"@en ; obo:IAO_0000115 "A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal"@en ; obo:IAO_0000116 "\"definitions\", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal."@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; a obo:IAO_0000409, owl:NamedIndividual ; rdfs:label "defined class"@en . obo:IAO_0000421 obo:IAO_0000111 "named class expression"@en ; obo:IAO_0000115 "A named class expression is a logical expression that is given a name. The name can be used in place of the expression."@en ; obo:IAO_0000116 "named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions"@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; a obo:IAO_0000409, owl:NamedIndividual ; rdfs:label "named class expression"@en . obo:IAO_0000422 obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A textual entity that is used as directive to deliver something to a person, or organization" ; obo:IAO_0000116 "2010-05-24 Alan Ruttenberg. Use label for the string representation. See issue https://github.com/information-artifact-ontology/IAO/issues/59" ; a owl:Class ; rdfs:label "postal address"@en ; rdfs:subClassOf obo:IAO_0000300, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GAZ_00000448 ] . obo:IAO_0000423 obo:IAO_0000111 "to be replaced with external ontology term"@en ; obo:IAO_0000115 "Terms with this status should eventually replaced with a term from another ontology."@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; obo:IAO_0000119 "group:OBI"@en ; a obo:IAO_0000078, owl:NamedIndividual ; rdfs:label "to be replaced with external ontology term"@en . obo:IAO_0000424 obo:IAO_0000111 "expand expression to"@en ; obo:IAO_0000112 """ObjectProperty: RO_0002104 Label: has plasma membrane part Annotations: IAO_0000424 \"http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)\" """@en ; obo:IAO_0000115 "A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones"@en ; obo:IAO_0000117 "Chris Mungall"@en ; a owl:AnnotationProperty ; rdfs:label "expand expression to"@en . obo:IAO_0000425 obo:IAO_0000111 "expand assertion to"@en ; obo:IAO_0000112 """ObjectProperty: RO??? Label: spatially disjoint from Annotations: expand_assertion_to \"DisjointClasses: (http://purl.obolibrary.org/obo/BFO_0000051 some ?X) (http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)\" """@en ; obo:IAO_0000115 "A macro expansion tag applied to an annotation property which can be expanded into a more detailed axiom."@en ; obo:IAO_0000117 "Chris Mungall"@en ; a owl:AnnotationProperty ; rdfs:label "expand assertion to"@en . obo:IAO_0000426 obo:IAO_0000111 "first order logic expression"@en ; obo:IAO_0000117 "PERSON:Alan Ruttenberg"@en ; a owl:AnnotationProperty ; rdfs:label "first order logic expression"@en . obo:IAO_0000427 obo:IAO_0000111 "antisymmetric property"@en ; obo:IAO_0000112 "part_of antisymmetric property xsd:true"@en ; obo:IAO_0000115 "Use boolean value xsd:true to indicate that the property is an antisymmetric property"@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; a owl:AnnotationProperty ; rdfs:label "antisymmetric property"@en . obo:IAO_0000428 obo:IAO_0000111 "requires discussion"@en ; obo:IAO_0000115 "A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues."@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; obo:IAO_0000119 "group:OBI"@en ; a obo:IAO_0000078, owl:NamedIndividual ; rdfs:label "requires discussion"@en . obo:IAO_0000429 obo:IAO_0000111 "email address"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000116 "Alan Ruttenberg 1/3/2012 - Provisional id, see issue at https://github.com/information-artifact-ontology/IAO/issues/130&thanks=130&ts=1325636583"@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en, "Person:Chris Stoeckart"@en ; a owl:Class ; rdfs:label "email address"@en ; rdfs:subClassOf obo:IAO_0000030 . obo:IAO_0000442 obo:IAO_0000111 "author role"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A role inhering in a person or organization that is realized when the bearer participates in the work which is the basis of the document, in the writing of the document, and signs it with their name."@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Melanie Courtot"@en ; a owl:Class ; rdfs:label "author role"@en ; rdfs:subClassOf obo:BFO_0000023 . obo:IAO_0000443 obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process in which journal articles are read or processed and data items are extracted, typically for further analysis or indexing" ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; a owl:Class ; rdfs:label "data item extraction from journal article" ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:IAO_0000013 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000027 ] . obo:IAO_0000572 obo:IAO_0000112 "Recording the current temperature in a laboratory notebook. Writing a journal article. Updating a patient record in a database."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A planned process in which a document is created or added to by including the specified input in it."@en ; obo:IAO_0000116 "6/11/9: Edited at OBI workshop. We need to be able identify a child form of information artifact which corresponds to something enduring (not brain like). This used to be restricted to physical document or digital entity as the output, but that excludes e.g. an audio cassette tape"@en ; obo:IAO_0000117 "Bjoern Peters"@en ; obo:IAO_0000119 "wikipedia http://en.wikipedia.org/wiki/Documenting"@en ; a owl:Class ; rdfs:label "documenting"@en ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:IAO_0000030 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000310 ] . obo:IAO_0000573 obo:IAO_0000111 "line graph"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 """A line graph is a type of graph created by connecting a series of data points together with a line."""@en ; obo:IAO_0000117 "PERSON:Chris Stoeckert"@en, "PERSON:Melanie Courtot"@en ; obo:IAO_0000118 "line chart"@en ; obo:IAO_0000119 "GROUP:OBI"@en, "WEB: http://en.wikipedia.org/wiki/Line_chart"@en ; a owl:Class ; rdfs:label "line graph"@en ; rdfs:subClassOf obo:IAO_0000038 . obo:IAO_0000574 obo:IAO_0000112 "A new pubmed ID being created for a journal article, and the associated pubmed record containing information to the journal article. A license plate number registered at the DMV to be belonging to a specific vehicle and owner. Placing a barcode on a product and entering information in a database that this barcode is assigned."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process in which a new CRID is created, associated with an entity, and stored in the CRID registry thereby registering it as being associated with some entity"@en ; obo:IAO_0000116 "2014-05-05: It is the CRID registry that assigns CRIDs, not the users of the registry."@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en, "Person:Bjoern Peters"@en, "Person:Melanie Courtot"@en ; obo:IAO_0000118 "assigning a CRID" ; a owl:Class ; rdfs:label "assigning a centrally registered identifier"@en ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000577 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom obo:IAO_0000579 ] . obo:IAO_0000575 obo:IAO_0000112 "Articles in Pubmed are reviewed by curators who add MESH terms to the Pubmed records in order to categorize them better and improve the ability to search for them. " ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process in which a CRID registry associates an information content entity with a CRID symbol"@en ; obo:IAO_0000117 "PERSON:Alan Ruttenberg"@en ; obo:IAO_0000118 "associating information with a CRID in the CRID registry" ; a owl:Class ; rdfs:label "associating information with a centrally registered identifier in its registry"@en ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:IAO_0000030 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:IAO_0000577 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom obo:IAO_0000579 ] . obo:IAO_0000576 obo:IAO_0000115 "a planned process with the objective to establish a system that allows to refer to specific entities of a certain kind and store information about them, by establishing a CRID registry and plan specifications for the process of 1) assigning a CRID and 2) looking up a CRID." ; obo:IAO_0000116 "MC, 20101124: deprecated following discussion at IAO call 20101124. Term was deemed not necessary - no use case for now." ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_establishing a CRID registry" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:IAO_0000577 obo:IAO_0000112 "The sentence \"The article has Pubmed ID 12345.\" contains a CRID that has two parts: one part is the CRID symbol, which is '12345'; the other part denotes the CRID registry, which is Pubmed."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A symbol that is part of a CRID and that is sufficient to look up a record from the CRID's registry."@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Bill Hogan"@en, "PERSON: Bjoern Peters"@en, "PERSON: Melanie Courtot"@en ; obo:IAO_0000118 "CRID symbol" ; obo:IAO_0000119 "Original proposal from Bjoern, discussions at IAO calls"@en ; a owl:Class ; rdfs:label "centrally registered identifier symbol"@en ; rdfs:subClassOf obo:IAO_0000028, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:IAO_0000578 ] . obo:IAO_0000578 obo:IAO_0000112 "The sentence \"The article has Pubmed ID 12345.\" contains a CRID that has two parts: one part is the CRID symbol, which is '12345'; the other part denotes the CRID registry, which is Pubmed."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An information content entity that consists of a CRID symbol and additional information about the CRID registry to which it belongs."@en ; obo:IAO_0000116 "2014-05-05: In defining this term we take no position on what the CRID denotes. In particular do not assume it denotes a *record* in the CRID registry (since the registry might not have 'records')."@en, """Alan, IAO call 20101124: potentially the CRID denotes the instance it was associated with during creation. """@en, "Note, IAO call 20101124: URIs are not always CRID, as not centrally registered. We acknowledge that CRID is a subset of a larger identifier class, but this subset fulfills our current needs. OBI PURLs are CRID as they are registered with OCLC. UPCs (Universal Product Codes from AC Nielsen)are not CRID as they are not centrally registered."@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Bill Hogan"@en, "PERSON: Bjoern Peters"@en, "PERSON: Melanie Courtot"@en ; obo:IAO_0000118 "CRID" ; obo:IAO_0000119 "Original proposal from Bjoern, discussions at IAO calls"@en ; a owl:Class ; rdfs:label "centrally registered identifier"@en ; rdfs:subClassOf obo:IAO_0000030, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000577 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000219 ; owl:someValuesFrom obo:IAO_0000579 ] ] . obo:IAO_0000579 obo:IAO_0000112 "PubMed is a CRID registry. It has a dataset of PubMed identifiers associated with journal articles. "@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A CRID registry is a dataset of CRID records, each consisting of a CRID symbol and additional information which was recorded in the dataset through a assigning a centrally registered identifier process."@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Bill Hogan"@en, "PERSON: Bjoern Peters"@en, "PERSON: Melanie Courtot"@en ; obo:IAO_0000118 "CRID registry" ; obo:IAO_0000119 "Original proposal from Bjoern, discussions at IAO calls"@en ; a owl:Class ; rdfs:label "centrally registered identifier registry"@en ; rdfs:subClassOf obo:IAO_0000100 . obo:IAO_0000580 obo:IAO_0000112 "Going to the PubMed website and entering a PubMed ID in order to retrieve the Pubmed information associated with that ID. " ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process in which a request to a CRID registry is made to return the information associated with a CRID symbol"@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Bill Hogan"@en, "PERSON: Bjoern Peters"@en, "PERSON: Melanie Courtot"@en ; obo:IAO_0000118 "looking up a CRID" ; a owl:Class ; rdfs:label "looking up a centrally registered identifier"@en ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:IAO_0000577 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000030 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom obo:IAO_0000579 ] . obo:IAO_0000581 obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "relates a time stamped measurement datum to the time measurement datum that denotes the time when the measurement was taken"@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; a owl:FunctionalProperty, owl:ObjectProperty ; rdfs:domain obo:IAO_0000582 ; rdfs:label "has time stamp"@en ; rdfs:range obo:IAO_0000416 ; rdfs:subPropertyOf obo:BFO_0000051 . obo:IAO_0000582 obo:IAO_0000114 obo:IAO_0000123 ; a owl:Class ; rdfs:label "time stamped measurement datum"@en ; rdfs:subClassOf obo:IAO_0000109, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:IAO_0000581 ; owl:someValuesFrom obo:IAO_0000416 ] [ a owl:Restriction ; owl:onProperty obo:IAO_0000583 ; owl:someValuesFrom obo:IAO_0000109 ] ) ] . obo:IAO_0000583 obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "relates a time stamped measurement datum to the measurement datum that was measured"@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; a owl:ObjectProperty ; rdfs:domain obo:IAO_0000582 ; rdfs:label "has measurement datum"@en ; rdfs:range [ a owl:Class ; owl:intersectionOf (obo:IAO_0000109 [ a owl:Class ; owl:complementOf obo:IAO_0000416 ] ) ] ; rdfs:subPropertyOf obo:BFO_0000051 . obo:IAO_0000584 obo:IAO_0000112 "pmid:20604925 - time-lapse live cell microscopy"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data set that is an aggregate of data recording some measurement at a number of time points. The time series data set is an ordered list of pairs of time measurement data and the corresponding measurement data acquired at that time."@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; obo:IAO_0000118 "experimental time series"@en ; a owl:Class ; rdfs:label "time sampled measurement data set"@en ; rdfs:subClassOf obo:IAO_0000100, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000582 ] . obo:IAO_0000589 obo:IAO_0000111 "OBO foundry unique label"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An alternative name for a class or property which is unique across the OBO Foundry."@en ; obo:IAO_0000116 "The intended usage of that property is as follow: OBO foundry unique labels are automatically generated based on regular expressions provided by each ontology, so that SO could specify unique label = 'sequence ' + [label], etc. , MA could specify 'mouse + [label]' etc. Upon importing terms, ontology developers can choose to use the 'OBO foundry unique label' for an imported term or not. The same applies to tools ."@en ; obo:IAO_0000117 "PERSON:Alan Ruttenberg"@en, "PERSON:Bjoern Peters"@en, "PERSON:Chris Mungall"@en, "PERSON:Melanie Courtot"@en ; obo:IAO_0000119 "GROUP:OBO Foundry "@en ; a owl:AnnotationProperty ; rdfs:label "OBO foundry unique label"@en . obo:IAO_0000590 obo:IAO_0000111 "written name"@en ; obo:IAO_0000112 "\"Bill Clinton\""@en, "\"The Eiffel Tower\""@en, "\"United States of America\""@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A textual entity that denotes a particular in reality."@en ; obo:IAO_0000117 "PERSON: Bill Hogan"@en ; obo:IAO_0000119 "https://github.com/information-artifact-ontology/IAO/issues/114"@en ; obo:IAO_0000232 "The qualifier \"written\" is to set it apart from spoken names. Also, note the restrictions to particulars. We are not naming universals. We could however, be naming, attributive collections which are particulars, so \"All people located in the boundaries of the city of Little Rock, AR on June 18, 2011 at 9:50a CDT\" would be a name."@en ; a owl:Class ; rdfs:label "written name"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000591 obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A software method (also called subroutine, subprogram, procedure, method, function, or routine) is software designed to execute a specific task."@en ; obo:IAO_0000117 "PERSON: Melanie Courtot"@en, "PERSON: Michel Dumontier"@en ; obo:IAO_0000119 "https://github.com/information-artifact-ontology/IAO/issues/80"@en ; a owl:Class ; rdfs:label "software method"@en ; rdfs:subClassOf obo:IAO_0000010 . obo:IAO_0000592 obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A software module is software composed of a collection of software methods."@en ; obo:IAO_0000117 "PERSON: Melanei Courtot"@en, "PERSON: Michel Dumontier"@en ; obo:IAO_0000119 "https://github.com/information-artifact-ontology/IAO/issues/80"@en ; a owl:Class ; rdfs:label "software module"@en ; rdfs:subClassOf obo:IAO_0000010 . obo:IAO_0000593 obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A software library is software composed of a collection of software modules and/or software methods in a form that can be statically or dynamically linked to some software application."@en ; obo:IAO_0000117 "PERSON: Melanie Courtot"@en, "PERSON: Michel Dumontier"@en ; obo:IAO_0000119 "https://github.com/information-artifact-ontology/IAO/issues/80"@en ; a owl:Class ; rdfs:label "software library"@en ; rdfs:subClassOf obo:IAO_0000010 . obo:IAO_0000594 obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A software application is software that can be directly executed by some processing unit."@en ; obo:IAO_0000117 "PERSON: Melanie Courtot"@en, "PERSON: Michel Dumontier"@en ; obo:IAO_0000119 "https://github.com/information-artifact-ontology/IAO/issues/80"@en ; a owl:Class ; rdfs:label "software application"@en ; rdfs:subClassOf obo:IAO_0000010 . obo:IAO_0000595 obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A software script is software whose instructions can be executed using a software interpreter."@en ; obo:IAO_0000117 "PERSON: Melanie Courtot"@en, "PERSON: Michel Dumontier"@en ; obo:IAO_0000119 "https://github.com/information-artifact-ontology/IAO/issues/80"@en ; a owl:Class ; rdfs:label "software script"@en ; rdfs:subClassOf obo:IAO_0000010 . obo:IAO_0000596 obo:IAO_0000111 "has ID digit count"@en ; obo:IAO_0000112 """Ontology: Annotations: 'has ID prefix': \"http://purl.obolibrary.org/obo/RO_\" 'has ID digit count' : 7, rdfs:label \"RO id policy\" 'has ID policy for': \"RO\""""@en ; obo:IAO_0000115 "Relates an ontology used to record id policy to the number of digits in the URI. The URI is: the 'has ID prefix\" annotation property value concatenated with an integer in the id range (left padded with \"0\"s to make this many digits)"@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en ; a owl:AnnotationProperty ; rdfs:label "has ID digit count"@en . obo:IAO_0000597 obo:IAO_0000111 "has ID range allocated"@en ; obo:IAO_0000112 """Datatype: idrange:1 Annotations: 'has ID range allocated to': \"Chris Mungall\" EquivalentTo: xsd:integer[> 2151 , <= 2300] """@en ; obo:IAO_0000115 "Relates a datatype that encodes a range of integers to the name of the person or organization who can use those ids constructed in that range to define new terms"@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en ; a owl:AnnotationProperty ; rdfs:label "has ID range allocated to"@en . obo:IAO_0000598 obo:IAO_0000111 "has ID policy for"@en ; obo:IAO_0000112 """Ontology: Annotations: 'has ID prefix': \"http://purl.obolibrary.org/obo/RO_\" 'has ID digit count' : 7, rdfs:label \"RO id policy\" 'has ID policy for': \"RO\""""@en ; obo:IAO_0000115 "Relating an ontology used to record id policy to the ontology namespace whose policy it manages"@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en ; a owl:AnnotationProperty ; rdfs:label "has ID policy for"@en . obo:IAO_0000599 obo:IAO_0000111 "has ID prefix"@en ; obo:IAO_0000112 """Ontology: Annotations: 'has ID prefix': \"http://purl.obolibrary.org/obo/RO_\" 'has ID digit count' : 7, rdfs:label \"RO id policy\" 'has ID policy for': \"RO\""""@en ; obo:IAO_0000115 "Relates an ontology used to record id policy to a prefix concatenated with an integer in the id range (left padded with \"0\"s to make this many digits) to construct an ID for a term being created."@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en ; a owl:AnnotationProperty ; rdfs:label "has ID prefix"@en . obo:IAO_0000600 obo:IAO_0000111 "elucidation"@en ; obo:IAO_0000117 "person:Alan Ruttenberg"@en ; obo:IAO_0000119 "Person:Barry Smith"@en ; obo:IAO_0000600 "Primitive terms in a highest-level ontology such as BFO are terms which are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms"@en ; a owl:AnnotationProperty ; rdfs:isDefinedBy ; rdfs:label "elucidation"@en . obo:IAO_0000601 obo:IAO_0000111 "has associated axiom(nl)"@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en ; obo:IAO_0000119 "Person:Alan Ruttenberg"@en ; obo:IAO_0000600 "An axiom associated with a term expressed using natural language"@en ; a owl:AnnotationProperty ; rdfs:isDefinedBy ; rdfs:label "has associated axiom(nl)"@en . obo:IAO_0000602 obo:IAO_0000111 "has associated axiom(fol)"@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en ; obo:IAO_0000119 "Person:Alan Ruttenberg"@en ; obo:IAO_0000600 "An axiom expressed in first order logic using CLIF syntax"@en ; a owl:AnnotationProperty ; rdfs:isDefinedBy ; rdfs:label "has associated axiom(fol)"@en . obo:IAO_0000603 obo:IAO_0000111 "is allocated id range"@en ; obo:IAO_0000115 "Relates an ontology IRI to an (inclusive) range of IRIs in an OBO name space. The range is give as, e.g. \"IAO_0020000-IAO_0020999\""@en ; obo:IAO_0000117 "PERSON:Alan Ruttenberg"@en ; a owl:AnnotationProperty ; rdfs:comment "Add as annotation triples in the granting ontology"@en ; rdfs:label "is allocated id range"@en . obo:IAO_0000604 obo:IAO_0000111 "retired from use as of"@en ; obo:IAO_0000115 "relates a class of CRID to the date after which further instances should not be made, according to the central authority" ; obo:IAO_0000116 "In OWL 2 add AnnotationPropertyRange xsd:dateTimeStamp"@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; a owl:AnnotationProperty ; rdfs:label "retired from use as of" . obo:IAO_0000605 obo:IAO_0000111 "abbreviation textual entity"@en ; obo:IAO_0000112 """From Shiba et al. Acta Neuropathol Commun. 2013; 1: 45. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893467/): BAC: Bacterial artificial chromosome; CR: Calretinin; GFAP: Glial fibrillary acidic protein; MAP: Microtubule-associated protein; MRI: Magnetic resonance imaging; NSC: Neural stem cell; PDA: Patent ductus arteriosus; PMG: Polymicrogyria; PNH: Periventricular nodular heterotopia; VSD: Ventricular septal defect."""@en ; obo:IAO_0000115 "A textual entity listing abbreviations and their expansions that are used in a document."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "abbreviation textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000606 obo:IAO_0000111 "abbreviations section"@en ; obo:IAO_0000112 "The section labelled 'abbreviations' in a typical scientific journal article."@en ; obo:IAO_0000115 "A part of a document where abbreviations and their long-forms used within the document are listed."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "abbreviations"@en, "abbreviations list"@en, "abbreviations used"@en, "list of abbreviations"@en, "list of abbreviations used"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "abbreviations section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000605 ] . obo:IAO_0000607 obo:IAO_0000111 "author information section"@en ; obo:IAO_0000112 "The section labelled 'author information' in a typical scientific journal article, e.g. in Takon. Ann Gen Psychiatry. 2011; 10: 25. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204268/)"@en ; obo:IAO_0000115 "A part of a document about the authors that provides biographical information and may discuss how the authors' professional experiences are relevant to the work described in the document."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "author information"@en, "authors’ information"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "author information section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000608 ] . obo:IAO_0000608 obo:IAO_0000111 "author information textual entity"@en ; obo:IAO_0000112 """From Takon. Ann Gen Psychiatry. 2011; 10: 25. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204268/): IT [the author] is the lead paediatrician for ADHD services in East Hertfordshire, UK, where she runs a weekly joint ADHD clinic with the Child and Adolescent psychiatrist and works within an ADHD specialist team. IT also sees children with other neurodisability issues who may have comorbid ADHD, where the presentation may be more complex and challenging to manage. IT has vast experience in managing children with complex ADHD. She has 18 years of experience in paediatrics and also has extensive experience in the use of psychopharmacologic agents in managing children with ADHD."""@en ; obo:IAO_0000115 "A textual entity expression information about an author of a document. This information may include biographical information and may discuss how the authors' professional experiences are relevant to the work described in the document."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "author information textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000609 obo:IAO_0000111 "author summary section"@en ; obo:IAO_0000112 "The section labelled 'synopsis' in a typical scientific journal article, e.g. in Pendse et al. BMC Genomics. 2013; 14: 136. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608171/)"@en ; obo:IAO_0000115 "A part of a document, distinct from the abstract, that describes the significance and broader context of the document content. The author summary is often written in a non-technical manner and is aimed at both scientists and non-scientist readers."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "author summary"@en, "summary"@en, "synopsis"@en ; obo:IAO_0000119 "Article submission guidelines for PLoS Genetics (http://journals.plos.org/plosgenetics/s/submission-guidelines)"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "author summary section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000610 ] . obo:IAO_0000610 obo:IAO_0000111 "author summary textual entity"@en ; obo:IAO_0000112 """From Pendse et al. BMC Genomics. 2013; 14: 136. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608171/): The search for genetic risk factors for common human diseases often relies on the use of linkage and association studies to establish correlation between genomic markers and disease risk. These studies require additional functional evaluation of candidate genes, including their possible interaction with diet and environment. The number of candidate genes is typically large and the development of appropriate genetic tools in mammalian systems is slow. By contrast, large-scale genetic screens, using widely available genetic tools, are routinely conducted in the fruit fly Drosophila melanogaster. In this study, we used Drosophila to screen candidate genes identified in human genome-wide scans as associated with risk of metabolic abnormalities such as type 2 diabetes. We show that a number of human candidate genes have fly orthologs that play an important role in Drosophila tolerance to high dietary sucrose. We further explored some of the specific metabolic abnormalities that can result when these genes’ activities are reduced in flies, focusing on a gene we call dHHEX (CG7056), the fly ortholog of human HHEX."""@en ; obo:IAO_0000115 "A textual entity, distinct from the abstract, that describes the significance and broader context of the document content. The author summary is often written in a non-technical manner and is aimed at both scientists and non-scientist readers, e.g as described in the article submission guidelines for PLoS Genetics (http://journals.plos.org/plosgenetics/s/submission-guidelines)."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000119 "Article submission guidelines for PLoS Genetics (http://journals.plos.org/plosgenetics/s/submission-guidelines)."@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "author summary textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000611 obo:IAO_0000111 "availability section"@en ; obo:IAO_0000112 "The section labelled 'availability and requirements' in a typical scientific journal article, e.g. Qi et al. BMC Bioinformatics. 2014; 15: 11. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897912/)."@en ; obo:IAO_0000115 "A part of a document about a resource described in the document, e.g. software, that describes where and/or how that resource can be obtained."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "availability"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "availability section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000612 ] . obo:IAO_0000612 obo:IAO_0000111 "availability textual entity"@en ; obo:IAO_0000112 """From Qi et al. BMC Bioinformatics. 2014; 15: 11. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897912/): Project home page:http://krux.googlecode.com"""@en ; obo:IAO_0000115 "A textual entity expressing the location of a resource, e.g. software, or the manner in which a resource can be obtained."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "availability textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000613 obo:IAO_0000111 "case report section"@en ; obo:IAO_0000112 "The section labelled 'case report' in a typical scientific journal article, e.g. in Taglia et al. Acta Myol. 2012 Dec; 31(3): 201–203. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631801/)"@en ; obo:IAO_0000115 "A part of a document about the medical history of a specific patient as it relates to the topic of the document."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "case presentation"@en, "case report"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "case report section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000614 ] . obo:IAO_0000614 obo:IAO_0000111 "case report textual entity"@en ; obo:IAO_0000112 """Excerpt from Taglia et al. Acta Myol. 2012 Dec; 31(3): 201–203. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631801/): The patient is a 50-year-old man. His medical history was not contributory. At the age of 37 years, he complained of persistent fatigue and dyspnoea even for modest efforts and oedema of lower limbs. The patient was examined at the department of internal medicine of the local hospital, and hospitalised with a diagnosis of dilated cardiomyopathy probably consequence of a myocarditis process. Soon after he was transferred to the cardiologic department of the regional hospital, and pharmacologically treated for heart failure and pulmonary hypertension."""@en ; obo:IAO_0000115 "A textual entity that expresses a detailed account of a portion of the medical history for a specific patient."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "case report textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000615 obo:IAO_0000111 "conclusion section"@en ; obo:IAO_0000112 "The section labelled 'conclusion' in a typical scientific journal article."@en ; obo:IAO_0000115 "A part of a document used to summarize the findings discussed in the document. The conclusion section is typically found near the end of a document."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "concluding remarks"@en, "conclusion"@en, "conclusions"@en, "findings"@en, "summary"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "conclusion section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000144 ] . obo:IAO_0000616 obo:IAO_0000111 "conflict of interest section"@en ; obo:IAO_0000112 "The section labelled 'conflict of interest statement' in a typical scientific journal article."@en ; obo:IAO_0000115 "A part of a document used to declare any competing interests regarding the authors and/or funding organization for the work described in the document."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "competing interests"@en, "conflict of interest"@en, "conflict of interest statement"@en, "declaration of competing interests"@en, "disclosure of potential conflicts of interest"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "conflict of interest section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000617 ] . obo:IAO_0000617 obo:IAO_0000111 "conflict of interest statement"@en ; obo:IAO_0000112 "SD [an author] is a Merck employee and Merck is the sponsor of this study. [Taken from 'Effects of obstructive sleep apnoea risk on postoperative respiratory complications: protocol for a hospital-based registry study' Shin et al. 2016 (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735131/)] "@en ; obo:IAO_0000115 "A textual entity that expresses a situation involving one or more of the authors, or the funding source of a document whereby the authors or funding source stand to potentially gain (typically financially) from the results reported in the document."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "conflict of interest textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000618 obo:IAO_0000111 "consent section"@en ; obo:IAO_0000112 "The section labelled 'consent' in a typical scientific journal article, e.g. Shiba et al. Acta Neuropathol Commun. 2013; 1: 45. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893467/)"@en ; obo:IAO_0000115 "A part of a document about the consent process that was used to enroll patients in a study."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "consent"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "consent section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000619 ] . obo:IAO_0000619 obo:IAO_0000111 "consent textual entity"@en ; obo:IAO_0000112 """From Shiba et al. Acta Neuropathol Commun. 2013; 1: 45. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893467/): Written informed consent was obtained from the patient’s parents for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor-in chief of this journal."""@en ; obo:IAO_0000115 "A textual entity that documents the consenting process used to enroll patients in a study."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "consent textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000620 obo:IAO_0000111 "ethical approval section"@en ; obo:IAO_0000112 "The section labelled 'ethical approval' in a typical scientific journal article."@en ; obo:IAO_0000115 "A part of a document about the governance body responsible for approving the work discussed in a document on an ethical basis."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "ethical approval"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "ethical approval section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000621 ] . obo:IAO_0000621 obo:IAO_0000111 "ethical approval textual entity"@en ; obo:IAO_0000112 """From McLean et al. Br J Gen Pract. 2014 Jul; 64(624): e440–e447 (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073730/): The NHS National Research Ethics Service had previously approved the use of these anonymised data for research purposes and this analysis did not require independent review."""@en ; obo:IAO_0000115 "A textual entity that documents the ethical approval of some study design."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "ethical approval textual entity"@en ; rdfs:subClassOf obo:IAO_0000300, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0500000 ] . obo:IAO_0000622 obo:IAO_0000111 "figures section"@en ; obo:IAO_0000112 "The section labelled 'figures' in a typical scientific journal article."@en ; obo:IAO_0000115 "A part of a document that contains one or more figures."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "figures"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "figures section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000308 ] . obo:IAO_0000623 obo:IAO_0000111 "funding source declaration section"@en ; obo:IAO_0000112 "The section labelled 'funding' in a typical scientific journal article."@en ; obo:IAO_0000115 "A part of a document used to detail information regarding the source of funding used in support of the generation of the document content."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "funding"@en, "funding information"@en, "funding sources"@en, "funding statement"@en, "funding/support"@en, "source of funding"@en, "sources of funding"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "funding source declaration section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000624 ] . obo:IAO_0000624 obo:IAO_0000111 "funding souce declaration textual entity"@en ; obo:IAO_0000112 """From Stephan et al. Accid Anal Prev. 2011 May; 43(3): 1062–1067. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062852/): This study was supported by the International Collaborative Research Grants Scheme with joint grants from the Wellcome Trust UK (GR071587MA) and the Australian NHMRC (268055). The funding sources played no role in study design, data collection, analysis or interpretation, writing the report, or the decision to submit the paper for publication."""@en ; obo:IAO_0000115 "A textual entity documenting the source of funding that supported some study."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "funding source declaration textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000625 obo:IAO_0000111 "future directions section"@en ; obo:IAO_0000112 "The section labelled 'future directions' in a typical scientific journal article."@en ; obo:IAO_0000115 "A part of a document detailing extensions of the described work that may be implemented at some future point in time."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "future challenges"@en, "future considerations"@en, "future developments"@en, "future directions"@en, "future outlook"@en, "future perspectives"@en, "future plans"@en, "future prospects"@en, "future research"@en, "future research directions"@en, "future studies"@en, "future work"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "future directions section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000626 ] . obo:IAO_0000626 obo:IAO_0000111 "future directions textual entity"@en ; obo:IAO_0000112 """Excerpt from Wang and Li. Acta Pharmacol Sin. 2016 Jan; 37(1): 25–33. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722976/): In the future, several questions will need to be resolved regarding the physiological assembly of KCNQ channels and their functional implications in complex neural circuits. First, we still lack sufficiently selective inhibitors and activators among the KCNQ family members."""@en ; obo:IAO_0000115 "A textual entity expressing ideas regarding future work relevant to work described in a document that could be done."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "future directions textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000627 obo:IAO_0000111 "genome announcement section"@en ; obo:IAO_0000112 "The section labelled 'genome announcement' in a typical scientific journal article, e.g. in Kim et al. J Bacteriol. 2011 Oct; 193(19): 5537. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187466/)"@en ; obo:IAO_0000115 "A document part announcing the publication of a novel draft genome sequence."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "genome announcement"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "genome announcement section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000628 ] . obo:IAO_0000628 obo:IAO_0000111 "genome announcement textual entity"@en ; obo:IAO_0000112 """Excerpt from Kim et al. J Bacteriol. 2011 Oct; 193(19): 5537. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187466/): Here we report the genome sequence of Lactobacillus malefermentans KCTC 3548, which we obtained using a whole-genome shotgun strategy (4) with Roche 454 GS (FLX Titanium) pyrosequencing (257,559 reads totaling ∼89.8 Mb; ∼45-fold coverage of the genome) at the Genome Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)."""@en ; obo:IAO_0000115 "A textual entity that describes the generation and public release of a novel, draft genome sequence."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "genome announcement textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000629 obo:IAO_0000111 "keyword textual entity"@en ; obo:IAO_0000112 """From: Fu and Lin. Identification of gene-oriented exon orthology between human and mouse. BMC Genomics. 2012; 13(Suppl 1): S10. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303729/): Exon orthology; alternative splicing; exon duplication; intron-exon structure."""@en ; obo:IAO_0000115 "A textual entity listing keywords indicating the major theme(s) of a document."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "keyword textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000630 obo:IAO_0000111 "keywords section"@en ; obo:IAO_0000112 "The section labelled 'keywords' in a typical scientific journal article."@en ; obo:IAO_0000115 "A part of a document where keywords selected by the author to categorize the major theme(s) of a document are listed."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "keywords"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "keywords section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000629 ] . obo:IAO_0000631 obo:IAO_0000111 "study limitations section"@en ; obo:IAO_0000112 "The section labelled 'limitations' in a typical scientific journal article."@en ; obo:IAO_0000115 "A part of a document about biases or short comings related to the study design and execution."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "limitations"@en, "study limitations"@en ; obo:IAO_0000119 "Author guidelines published by The Society for Academic Emergency Medicine. (http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1553-2712/homepage/ForAuthors.html)"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "study limitations section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000632 ], [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0500000 ] . obo:IAO_0000632 obo:IAO_0000111 "study limitations textual entity"@en ; obo:IAO_0000112 """Excerpt from the Limitations section of Fermann et al 2015, Acad Emerg Med. 2015 Mar; 22(3): 299–307 (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405051/). Owing to the nature of a post hoc study, any significant values must be interpreted with caution. In the current analysis, no multiple testing was conducted and p-values remain unadjusted. Moreover, a selection bias arising from the randomized open-label design of the original EINSTEIN PE study cannot be ruled out."""@en ; obo:IAO_0000115 "A textual entity addressing a shortcoming or bias of a study design or execution."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000119 "Author guidelines published by The Society for Academic Emergency Medicine. (http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1553-2712/homepage/ForAuthors.html)"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "study limitations textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000633 obo:IAO_0000111 "materials section"@en ; obo:IAO_0000112 "The section labelled 'materials' in a typical scientific journal article, e.g. Nguyen et al. BMC Bioinformatics. 2010; 11: 279. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889936/)"@en ; obo:IAO_0000115 "A part of a document about the materials required to reproduce the content of the document."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "materials"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "materials section"@en ; rdfs:subClassOf obo:IAO_0000314 . obo:IAO_0000634 obo:IAO_0000111 "notes section"@en ; obo:IAO_0000112 "The section labelled 'notes' in a typical scientific journal article, e.g. McLean et al. Br J Gen Pract. 2014 Jul; 64(624): e440–e447 (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073730/):"@en ; obo:IAO_0000115 "A part of a document containing typically short notes about the document itself and/or the authors. Often the notes section contains subsections related to funding, competing interests, ethical approval, etc."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "footnotes"@en, "notes"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "notes section"@en ; rdfs:subClassOf obo:IAO_0000314 . obo:IAO_0000635 obo:IAO_0000111 "patients section"@en ; obo:IAO_0000112 "The section labelled 'patients' in a typical scientific journal article, e.g. in Citak et al. Acta Orthop. 2013 Jun; 84(3): 326–327. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715825/)"@en ; obo:IAO_0000115 "A part of a document about the patients that participated in a study."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "patients section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000636 ] . obo:IAO_0000636 obo:IAO_0000111 "patients textual entity"@en ; obo:IAO_0000112 """Excerpt from Citak et al. Acta Orthop. 2013 Jun; 84(3): 326–327. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715825/): Between January 1996 and February 2012, we treated 4 patients with interprosthetic femoral fractures (3 of them women) (Figure 2) using a custom-made interposition device (Waldemar Link GmbH, Hamburg, Germany) (Figure 1). Mean age was 74 (59–86) years. The fractures occurred mean 18 (13–28) years after primary THA and mean 14 (10–17) years after primary TKA. At the latest follow-up, after mean 8 (0.5–16) years, revision surgery with a total femur replacement was required in 1 case due to aseptic loosening. No other complications requiring revision surgery occurred."""@en ; obo:IAO_0000115 "A textual entity expressing information regarding the patients used in a study."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "patients textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000637 obo:IAO_0000111 "pre-publication history section"@en ; obo:IAO_0000112 "The section labelled 'pre-publication history' in a typical scientific journal article, e.g. in Xiao et al. BMC Anesthesiol. 2013; 13: 33. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016475/)"@en ; obo:IAO_0000115 "A part of the document about the publication history of a document. This section typically details dates of document submission to a journal and dates of any re-submissions as well as reviewer comments and responses to reviewers by the authors."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "notice of republication"@en, "pre-publication history"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "pre-publication history section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000638 ] . obo:IAO_0000638 obo:IAO_0000111 "pre-publication history textual entity"@en ; obo:IAO_0000112 """From Xiao et al. BMC Anesthesiol. 2013; 13: 33. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016475/): The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2253/13/33/prepub"""@en ; obo:IAO_0000115 "A textual entity that expresses the pre-publication history (submission dates, reviewer comments, etc) for a document, often including a hyperlink to a web page detailing the information."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "pre-publication history textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000639 obo:IAO_0000111 "related work section"@en ; obo:IAO_0000112 "The section labelled 'related work' in a typical scientific journal article, e.g. Žitnik and Zupan. Bioinformatics. 2015 Jun 15; 31(12): i230–i239. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542780/)"@en ; obo:IAO_0000115 "A part of a document about work in other publications that is relevant to the content of the document."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "related literature"@en, "related work"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "related work section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000640 ] . obo:IAO_0000640 obo:IAO_0000111 "related work textual entity"@en ; obo:IAO_0000112 """Excerpt from Žitnik and Zupan. Bioinformatics. 2015 Jun 15; 31(12): i230–i239. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542780/): Our work presented here is similar in spirit to our recently developed methodology for data fusion via collective matrix factorization (Žitnik and Zupan, 2015). """@en ; obo:IAO_0000115 "A textual entity that discusses work from other publications and expresses their relevancy to the content of a document."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "related work textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000641 obo:IAO_0000111 "requirements section"@en ; obo:IAO_0000112 "The section labelled 'availability and requirements' in a typical scientific journal article, e.g. Qi et al. BMC Bioinformatics. 2014; 15: 11. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897912/)."@en ; obo:IAO_0000115 "A part of a document about a resource described in the document, e.g. software, that describes the requirements necessary to use the resource, e.g. operating systems, hardware, etc. in the case of a software resource."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "requirements"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "requirements section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000642 ] . obo:IAO_0000642 obo:IAO_0000111 "requirements textual entity"@en ; obo:IAO_0000112 """From Qi et al. BMC Bioinformatics. 2014; 15: 11. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897912/): • Operating systems: Platform independent • Programming language: Matlab, R, Python • Other requirements: None • License: GNU GPL v3 • Any restrictions to use by non-academics: None"""@en ; obo:IAO_0000115 "A textual entity that expresses the requirements necessary to use a resource, e.g. software."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "requirements textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000643 obo:IAO_0000111 "statistical analysis textual entity"@en ; obo:IAO_0000112 """From Mondo et al. Cardiovasc J Afr. 2013 Mar; 24(2): 28–33. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734881/): Data were captured into EPI-DATA (version 3.1), cleaned and then exported to Stata version 10 for analysis. Continuous variables were summarised as mean (± standard deviation) and median (inter-quartile range), and presented in the tables. Categorical data were analysed using frequency and percentages, and results are presented in frequency tables and bar charts. Test of significance (p-value) was determined using the chi-square test. A p-value of less than 0.05 was considered significant."""@en ; obo:IAO_0000115 "A textual entity documenting statistical analysis tools and techniques employed."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "statistical analysis textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:IAO_0000644 obo:IAO_0000111 "statistical analysis section"@en ; obo:IAO_0000112 "The section labelled 'statistical analysis' in a typical scientific journal article, e.g. Mondo et al. Cardiovasc J Afr. 2013 Mar; 24(2): 28–33. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734881/)"@en ; obo:IAO_0000115 "A part of the document used to describe the statistical methodologies employed in the work presented in the document."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "statistical analysis"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "statistical analysis section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000643 ] . obo:IAO_0000645 obo:IAO_0000111 "tables section"@en ; obo:IAO_0000112 "The section labelled 'tables' in a typical scientific journal article."@en ; obo:IAO_0000115 "A part of a document that contains one or more tables."@en ; obo:IAO_0000117 "PERSON: Bill Baumgartner"@en ; obo:IAO_0000118 "tables"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "tables section"@en ; rdfs:subClassOf obo:IAO_0000314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000306 ] . obo:IAO_0000646 obo:IAO_0000115 "An identifier that denotes some postal delivery route, some aggregate of postal delivery routes or a geographical region and was created for the purpose of sorting and delivering mail."@en ; obo:IAO_0000117 "Mathias Brochhausen"@en ; a owl:Class ; rdfs:label "postal code"@en ; rdfs:subClassOf obo:IAO_0020000 . obo:IAO_0000647 obo:IAO_0000115 "A plan specification that if realized, is realized by the delivery of mail to some facility or mailbox within some geographical region."@en ; obo:IAO_0000117 "Mathias Brochhausen"@en ; a owl:Class ; rdfs:label "Postal delivery route"@en ; rdfs:subClassOf obo:IAO_0000104 . obo:IAO_0000648 obo:IAO_0000115 "A postal code that is used in the United States for the purpose of sorting and delivering mail, and that denotes some postal delivery route or some aggregate of postal delivery routes."@en ; obo:IAO_0000117 "Mathias Brochhausen"@en ; obo:IAO_0000118 "ZIP code"@en ; a owl:Class ; rdfs:label "zone improvement plan code"@en ; rdfs:subClassOf obo:IAO_0000646 . obo:IAO_0000650 obo:IAO_0000111 "database extract, transform, and load process"@en ; obo:IAO_0000115 "A planned process which takes as input a database and fills another database by extracting concretizations of information entities from the first, transforming them, and loading the transformed concretizations into the second."@en ; obo:IAO_0000116 "Alan Ruttenberg 12/21/16: Maybe this definition instead: A planned process which takes as input a database and copies concretizations from the first, optionally transforms then copies the result to the second", "Alan Ruttenberg 12/21/16: We don't define database in IAO, currently, as the bare word is ambiguous. Reasonable interpretations of the word might be the material entity, an information structure, an information content entity. However this definition commits, at least, to there being some material thing which bear concretizations of information entities and that there are new concretizations created during the process. We consider the ETL process in terms of information entities rather than the concretizations. No committment is made as to whether the specified output."@en ; obo:IAO_0000117 "PERSON:Alan Ruttenberg" ; obo:IAO_0000118 "ETL"@en ; obo:IAO_0000119 "WEB:https://en.wikipedia.org/wiki/Extract,_transform,_load" ; obo:IAO_0000233 ; a owl:Class ; rdfs:isDefinedBy ; rdfs:label "database extract, transform, and load process"@en ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:IAO_0000030 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000030 ] ; foaf:page . obo:IAO_0000700 obo:IAO_0000111 "has ontology root term"@en ; obo:IAO_0000115 "Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root."@en ; obo:IAO_0000117 "Nicolas Matentzoglu"@en ; a owl:AnnotationProperty ; rdfs:label "has ontology root term"@en . obo:IAO_0006011 obo:IAO_0000111 "may be identical to"@en ; obo:IAO_0000115 "A annotation relationship between two terms in an ontology that may refer to the same (natural) type but where more evidence is required before terms are merged."@en ; obo:IAO_0000117 "David Osumi-Sutherland"@en ; obo:IAO_0000233 "#40"@en ; obo:IAO_0000234 "VFB"@en ; a owl:AnnotationProperty ; rdfs:comment "Edges asserting this should be annotated with to record evidence supporting the assertion and its provenance."@en ; rdfs:label "may be identical to"@en . obo:IAO_0006012 obo:IAO_0000111 "scheduled for obsoletion on or after"@en ; obo:IAO_0000115 "Used when the class or object is scheduled for obsoletion/deprecation on or after a particular date."@en ; obo:IAO_0000117 "Chris Mungall, Jie Zheng"@en ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/15532"@en, "https://github.com/information-artifact-ontology/ontology-metadata/issues/32"@en ; obo:IAO_0000234 "GO ontology"@en ; a owl:AnnotationProperty ; rdfs:label "scheduled for obsoletion on or after"@en ; rdfs:range xsd:dateTime . obo:IAO_0010000 obo:IAO_0000111 "has axiom id"@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en ; obo:IAO_0000119 "Person:Alan Ruttenberg"@en ; obo:IAO_0000600 "A URI that is intended to be unique label for an axiom used for tracking change to the ontology. For an axiom expressed in different languages, each expression is given the same URI"@en ; a owl:AnnotationProperty ; rdfs:isDefinedBy ; rdfs:label "has axiom label"@en . obo:IAO_0020000 obo:IAO_0000111 "identifier"@en ; obo:IAO_0000115 "An identifier is an information content entity that is the outcome of a dubbing process and is used to refer to one instance of entity shared by a group of people to refer to that individual entity."@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "identifier"@en ; rdfs:subClassOf obo:IAO_0000030 . obo:IAO_0100001 obo:IAO_0000111 "term replaced by"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Use on obsolete terms, relating the term to another term that can be used as a substitute"@en ; obo:IAO_0000117 "Person:Alan Ruttenberg"@en ; obo:IAO_0000119 "Person:Alan Ruttenberg"@en ; a owl:AnnotationProperty ; rdfs:comment "Add as annotation triples in the granting ontology"@en ; rdfs:label "term replaced by"@en . obo:IAO_8000000 obo:IAO_0000111 "ontology module"@en ; obo:IAO_0000116 "I have placed this under 'data about an ontology part', but this can be discussed. I think this is OK if 'part' is interpreted reflexively, as an ontology module is the whole ontology rather than part of it."@en ; obo:IAO_0000118 "ontology file"@en ; obo:IAO_0000232 "This class and it's subclasses are applied to OWL ontologies. Using an rdf:type triple will result in problems with OWL-DL. I propose that dcterms:type is instead used to connect an ontology URI with a class from this hierarchy. The class hierarchy is not disjoint, so multiple assertions can be made about a single ontology."@en ; a owl:Class ; rdfs:label "ontology module"@en ; rdfs:subClassOf obo:IAO_0000102 . obo:IAO_8000001 obo:IAO_0000111 "base ontology module"@en ; obo:IAO_0000115 "An ontology module that comprises only of asserted axioms local to the ontology, excludes import directives, and excludes axioms or declarations from external ontologies."@en ; a owl:Class ; rdfs:label "base ontology module"@en ; rdfs:seeAlso ; rdfs:subClassOf obo:IAO_8000000 . obo:IAO_8000002 obo:IAO_0000111 "editors ontology module"@en ; obo:IAO_0000115 "An ontology module that is intended to be directly edited, typically managed in source control, and typically not intended for direct consumption by end-users."@en ; obo:IAO_0000118 "source ontology module"@en ; a owl:Class ; rdfs:label "editors ontology module"@en ; rdfs:subClassOf obo:IAO_8000000 . obo:IAO_8000003 obo:IAO_0000111 "main release ontology module"@en ; obo:IAO_0000115 "An ontology module that is intended to be the primary release product and the one consumed by the majority of tools."@en ; obo:IAO_0000116 "TODO: Add logical axioms that state that a main release ontology module is derived from (directly or indirectly) an editors module"@en ; a owl:Class ; rdfs:label "main release ontology module"@en ; rdfs:subClassOf obo:IAO_8000000 . obo:IAO_8000004 obo:IAO_0000111 "bridge ontology module"@en ; obo:IAO_0000115 "An ontology module that consists entirely of axioms that connect or bridge two distinct ontology modules. For example, the Uberon-to-ZFA bridge module."@en ; a owl:Class ; rdfs:label "bridge ontology module"@en ; rdfs:seeAlso ; rdfs:subClassOf obo:IAO_8000000 . obo:IAO_8000005 obo:IAO_0000111 "import ontology module"@en ; obo:IAO_0000115 "A subset ontology module that is intended to be imported from another ontology."@en ; obo:IAO_0000116 "TODO: add axioms that indicate this is the output of a module extraction process."@en ; obo:IAO_0000118 "import file"@en ; a owl:Class ; rdfs:label "import ontology module"@en ; rdfs:seeAlso ; rdfs:subClassOf obo:IAO_8000006 . obo:IAO_8000006 obo:IAO_0000111 "subset ontology module"@en ; obo:IAO_0000115 "An ontology module that is extracted from a main ontology module and includes only a subset of entities or axioms."@en ; obo:IAO_0000118 "ontology slim"@en, "subset ontology"@en ; a owl:Class ; rdfs:label "subset ontology module"@en ; rdfs:seeAlso , ; rdfs:subClassOf obo:IAO_8000000 . obo:IAO_8000007 obo:IAO_0000111 "curation subset ontology module"@en ; obo:IAO_0000115 "A subset ontology that is intended as a whitelist for curators using the ontology. Such a subset will exclude classes that curators should not use for curation."@en ; a owl:Class ; rdfs:label "curation subset ontology module"@en ; rdfs:subClassOf obo:IAO_8000006 . obo:IAO_8000008 obo:IAO_0000111 "analysis ontology module"@en ; obo:IAO_0000115 "An ontology module that is intended for usage in analysis or discovery applications."@en ; a owl:Class ; rdfs:label "analysis subset ontology module"@en ; rdfs:subClassOf obo:IAO_8000006 . obo:IAO_8000009 obo:IAO_0000111 "single layer ontology module"@en ; obo:IAO_0000115 "A subset ontology that is largely comprised of a single layer or strata in an ontology class hierarchy. The purpose is typically for rolling up for visualization. The classes in the layer need not be disjoint."@en ; obo:IAO_0000118 "ribbon subset"@en ; a owl:Class ; rdfs:label "single layer subset ontology module"@en ; rdfs:subClassOf obo:IAO_8000006 . obo:IAO_8000010 obo:IAO_0000111 "exclusion subset ontology module"@en ; obo:IAO_0000115 "A subset of an ontology that is intended to be excluded for some purpose. For example, a blacklist of classes."@en ; obo:IAO_0000118 "antislim"@en ; a owl:Class ; rdfs:label "exclusion subset ontology module"@en ; rdfs:subClassOf obo:IAO_8000006 . obo:IAO_8000011 obo:IAO_0000111 "external import ontology module"@en ; obo:IAO_0000115 "An imported ontology module that is derived from an external ontology. Derivation methods include the OWLAPI SLME approach."@en ; obo:IAO_0000118 "external import"@en ; a owl:Class ; rdfs:label "external import ontology module"@en ; rdfs:subClassOf obo:IAO_8000005 . obo:IAO_8000012 obo:IAO_0000111 "species subset ontology module"@en ; obo:IAO_0000115 "A subset ontology that is crafted to either include or exclude a taxonomic grouping of species."@en ; obo:IAO_0000118 "taxon subset"@en ; a owl:Class ; rdfs:label "species subset ontology module"@en ; rdfs:seeAlso ; rdfs:subClassOf obo:IAO_8000006 . obo:IAO_8000013 obo:IAO_0000111 "reasoned ontology module"@en ; obo:IAO_0000115 "An ontology module that contains axioms generated by a reasoner. The generated axioms are typically direct SubClassOf axioms, but other possibilities are available."@en ; a owl:Class ; rdfs:label "reasoned ontology module"@en ; rdfs:seeAlso ; rdfs:subClassOf obo:IAO_8000000 . obo:IAO_8000014 obo:IAO_0000111 "generated ontology module"@en ; obo:IAO_0000115 "An ontology module that is automatically generated, for example via a SPARQL query or via template and a CSV."@en ; obo:IAO_0000116 "TODO: Add axioms (using PROV-O?) that indicate this is the output-of some reasoning process"@en ; a owl:Class ; rdfs:label "generated ontology module"@en ; rdfs:subClassOf obo:IAO_8000000 . obo:IAO_8000015 obo:IAO_0000111 "template generated ontology module"@en ; obo:IAO_0000115 "An ontology module that is automatically generated from a template specification and fillers for slots in that template."@en ; a owl:Class ; rdfs:label "template generated ontology module"@en ; rdfs:seeAlso , , ; rdfs:subClassOf obo:IAO_8000014 . obo:IAO_8000016 obo:IAO_0000111 "taxonomic bridge ontology module"@en ; a owl:Class ; rdfs:label "taxonomic bridge ontology module"@en ; rdfs:subClassOf obo:IAO_8000004 . obo:IAO_8000017 obo:IAO_0000111 "ontology module subsetted by expressivity"@en ; a owl:Class ; rdfs:label "ontology module subsetted by expressivity"@en ; rdfs:subClassOf obo:IAO_8000006 . obo:IAO_8000018 obo:IAO_0000111 "obo basic subset ontology module"@en ; obo:IAO_0000115 """A subset ontology that is designed for basic applications to continue to make certain simplifying assumptions; many of these simplifying assumptions were based on the initial version of the Gene Ontology, and have become enshrined in many popular and useful tools such as term enrichment tools. Examples of such assumptions include: traversing the ontology graph ignoring relationship types using a naive algorithm will not lead to cycles (i.e. the ontology is a DAG); every referenced term is declared in the ontology (i.e. there are no dangling clauses). An ontology is OBO Basic if and only if it has the following characteristics: DAG Unidirectional No Dangling Clauses Fully Asserted Fully Labeled No equivalence axioms Singly labeled edges No qualifier lists No disjointness axioms No owl-axioms header No imports"""@en ; a owl:Class ; rdfs:label "obo basic subset ontology module"@en ; rdfs:seeAlso ; rdfs:subClassOf obo:IAO_8000017 . obo:IAO_8000019 obo:IAO_0000111 "ontology module subsetted by OWL profile"@en ; a owl:Class ; rdfs:label "ontology module subsetted by OWL profile"@en ; rdfs:subClassOf obo:IAO_8000017 . obo:IAO_8000020 obo:IAO_0000111 "EL++ ontology module"@en ; a owl:Class ; rdfs:label "EL++ ontology module"@en ; rdfs:subClassOf obo:IAO_8000019 . obo:IDO_0000450 obo:IAO_0000111 "pathogenic disposition"@en ; obo:IAO_0000115 "A disposition to initiate processes that result in a disorder."@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "pathogenic disposition"@en ; rdfs:subClassOf obo:BFO_0000016 . obo:IDO_0000528 obo:IAO_0000111 "pathogen"@en ; obo:IAO_0000115 "A material entity with a pathogenic disposition."@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "pathogen"@en ; rdfs:subClassOf obo:BFO_0000040 . obo:IDO_0000562 obo:IAO_0000111 "antibacterial"@en ; obo:IAO_0000115 "A material entity bearing an antibacterial disposition."@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "antibacterial"@en ; rdfs:subClassOf obo:BFO_0000040 . obo:IDO_0000586 obo:IAO_0000111 "infection"@en ; obo:IAO_0000115 "A part of an extended organism that itself has as part a population of one or more infectious agents and that (1) exists as a result of processes initiated by members of the infectious agent population and is (2) clinically abnormal in virtue of the presence of this infectious agent population, or (3) has a disposition to bring clinical abnormality to immunocompetent organisms of the same Species as the host (the organism corresponding to the extended organism) through transmission of a member or offspring of a member of the infectious agent population."@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "infection"@en ; rdfs:subClassOf obo:BFO_0000040 . obo:IDO_0000666 obo:IAO_0000111 "human pathogenicity disposition"@en ; obo:IAO_0000115 "A disposition to initiate processes that result in a disorder in a human organism." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "human pathogenicity disposition"@en ; rdfs:subClassOf obo:IDO_0000450 . obo:MRO_0000013 obo:IAO_0000111 "HLA-DR protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "HLA-DR protein complex" ; rdfs:subClassOf obo:MRO_0001455 . obo:MRO_0000966 obo:IAO_0000111 "H2-Db protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "H2-Db protein complex" ; rdfs:subClassOf obo:MRO_0001759 . obo:MRO_0000967 obo:IAO_0000111 "H2-Dd protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "H2-Dd protein complex" ; rdfs:subClassOf obo:MRO_0001460 . obo:MRO_0000971 obo:IAO_0000111 "H2-IA protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "H2-IA protein complex" ; rdfs:subClassOf obo:MRO_0001461 . obo:MRO_0000973 obo:IAO_0000111 "H2-IAd protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "H2-IAd protein complex" ; rdfs:subClassOf obo:MRO_0000971 . obo:MRO_0000975 obo:IAO_0000111 "H2-IAg7 protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "H2-IAg7 protein complex" ; rdfs:subClassOf obo:MRO_0000971 . obo:MRO_0000991 obo:IAO_0000111 "H2-Kb protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "H2-Kb protein complex" ; rdfs:subClassOf obo:MRO_0001759 . obo:MRO_0000992 obo:IAO_0000111 "H2-Kd protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "H2-Kd protein complex" ; rdfs:subClassOf obo:MRO_0001460 . obo:MRO_0000994 obo:IAO_0000111 "H2-Ks protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "H2-Ks protein complex" ; rdfs:subClassOf obo:MRO_0001460 . obo:MRO_0000997 obo:IAO_0000111 "H2-Ld protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "H2-Ld protein complex" ; rdfs:subClassOf obo:MRO_0001460 . obo:MRO_0001149 obo:IAO_0000111 "HLA-C protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "HLA-C protein complex" ; rdfs:subClassOf obo:MRO_0001454 . obo:MRO_0001167 obo:IAO_0000111 "HLA-DP protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "HLA-DP protein complex" ; rdfs:subClassOf obo:MRO_0001455 . obo:MRO_0001355 obo:IAO_0000111 "MHC class I protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "MHC class I protein complex" ; rdfs:subClassOf obo:GO_0042611 . obo:MRO_0001356 obo:IAO_0000111 "MHC class II protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "MHC class II protein complex" ; rdfs:subClassOf obo:GO_0042611 . obo:MRO_0001434 obo:IAO_0000111 "cattle MHC class I protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cattle MHC class I protein complex" ; rdfs:subClassOf obo:MRO_0001355 . obo:MRO_0001435 obo:IAO_0000111 "cattle MHC class II protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cattle MHC class II protein complex" ; rdfs:subClassOf obo:MRO_0001356 . obo:MRO_0001454 obo:IAO_0000111 "human MHC class I protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "human MHC class I protein complex" ; rdfs:subClassOf obo:MRO_0001355 . obo:MRO_0001455 obo:IAO_0000111 "human MHC class II protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "human MHC class II protein complex" ; rdfs:subClassOf obo:MRO_0001356 . obo:MRO_0001460 obo:IAO_0000111 "mouse MHC class I protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mouse MHC class I protein complex" ; rdfs:subClassOf obo:MRO_0001355 . obo:MRO_0001461 obo:IAO_0000111 "mouse MHC class II protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mouse MHC class II protein complex" ; rdfs:subClassOf obo:MRO_0001356 . obo:MRO_0001465 obo:IAO_0000111 "pig MHC class I protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "pig MHC class I protein complex" ; rdfs:subClassOf obo:MRO_0001355 . obo:MRO_0001498 obo:IAO_0000111 "mouse MHC protein complex with H2-p haplotype" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mouse MHC protein complex with H2-p haplotype" ; rdfs:subClassOf obo:GO_0042611 . obo:MRO_0001530 obo:IAO_0000111 "HLA protein complex with A2 serotype" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "HLA protein complex with A2 serotype" ; rdfs:subClassOf obo:GO_0042611 . obo:MRO_0001533 obo:IAO_0000111 "HLA protein complex with A24 serotype" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "HLA protein complex with A24 serotype" ; rdfs:subClassOf obo:GO_0042611 . obo:MRO_0001537 obo:IAO_0000111 "HLA protein complex with A28 serotype" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "HLA protein complex with A28 serotype" ; rdfs:subClassOf obo:GO_0042611 . obo:MRO_0001538 obo:IAO_0000111 "HLA protein complex with A29 serotype" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "HLA protein complex with A29 serotype" ; rdfs:subClassOf obo:GO_0042611 . obo:MRO_0001557 obo:IAO_0000111 "HLA protein complex with B27 serotype" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "HLA protein complex with B27 serotype" ; rdfs:subClassOf obo:GO_0042611 . obo:MRO_0001622 obo:IAO_0000111 "HLA protein complex with DQ3 serotype" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "HLA protein complex with DQ3 serotype" ; rdfs:subClassOf obo:GO_0042611 . obo:MRO_0001759 obo:IAO_0000111 "mouse MHC class I protein complex with H2-b haplotype" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mouse MHC class I protein complex with H2-b haplotype" ; rdfs:subClassOf obo:MRO_0001460 . obo:MRO_0001790 obo:IAO_0000111 "rat MHC class I protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "rat MHC class I protein complex" ; rdfs:subClassOf obo:MRO_0001355 . obo:MRO_0001793 obo:IAO_0000111 "rat MHC class II protein complex with RT1-A haplotype" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "rat MHC class II protein complex with RT1-A haplotype" ; rdfs:subClassOf obo:MRO_0001356 . obo:MRO_0002026 obo:IAO_0000111 "H2-Dq protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "H2-Dq protein complex" ; rdfs:subClassOf obo:MRO_0001460 . obo:MRO_0002027 obo:IAO_0000111 "H2-Kq protein complex" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "H2-Kq protein complex" ; rdfs:subClassOf obo:MRO_0001460 . obo:NCBITaxon_10090 obo:IAO_0000111 "Mus musculus" ; obo:IAO_0000118 "house mouse", "mouse" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Mus musculus" ; rdfs:subClassOf obo:NCBITaxon_39107 . obo:NCBITaxon_10116 obo:IAO_0000111 "Rattus norvegicus" ; obo:IAO_0000118 "Norway rat", "brown rat", "rat", "rats" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Rattus norvegicus" ; rdfs:subClassOf obo:NCBITaxon_39107 . obo:NCBITaxon_10239 obo:IAO_0000111 "Viruses" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Viruses" ; rdfs:subClassOf obo:OBI_0100026 . obo:NCBITaxon_10292 obo:IAO_0000111 "Herpesviridae" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Herpesviridae" ; rdfs:subClassOf obo:NCBITaxon_10239 . obo:NCBITaxon_10358 obo:IAO_0000111 "Cytomegalovirus" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Cytomegalovirus" ; rdfs:subClassOf obo:NCBITaxon_10292 . obo:NCBITaxon_10376 obo:IAO_0000111 "Human gammaherpesvirus 4" ; obo:IAO_0000118 "Epstein Barr virus", "Epstein-Barr virus", "Epstein-Barr virus EBV", "Human herpesvirus 4", "Human herpesvirus type 4" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Human gammaherpesvirus 4" ; rdfs:subClassOf obo:NCBITaxon_10292 . obo:NCBITaxon_10407 obo:IAO_0000111 "Hepatitis B virus" ; obo:IAO_0000118 "Human hepatitis B virus", "hepatitis B virus (HBV)", "hepatitis B virus HBV", "hepatitis B virus, HBV", "human hepatitis B virus HBV" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Hepatitis B virus" ; rdfs:subClassOf obo:NCBITaxon_2732514 . obo:NCBITaxon_11050 obo:IAO_0000111 "Flaviviridae" ; obo:IAO_0000118 "Flavivirus (arbovirus group B)" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Flaviviridae" ; rdfs:subClassOf obo:NCBITaxon_2732406 . obo:NCBITaxon_11103 obo:IAO_0000111 "Hepacivirus C" ; obo:IAO_0000118 "Hepatitis C virus", "hepatitis C virus HCV", "human hepatitis C virus", "human hepatitis C virus HCV", "human hepatitis virus C HCV", "post-transfusion hepatitis non A non B virus" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Hepacivirus C" ; rdfs:subClassOf obo:NCBITaxon_11050 . obo:NCBITaxon_11646 obo:IAO_0000111 "Lentivirus" ; obo:IAO_0000118 "Lentivirinae" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Lentivirus" ; rdfs:subClassOf obo:NCBITaxon_2732514 . obo:NCBITaxon_11676 obo:IAO_0000111 "Human immunodeficiency virus 1" ; obo:IAO_0000118 "human immunodeficiency virus 1 HIV-1", "human immunodeficiency virus HIV-1", "human immunodeficiency virus type 1 HIV 1", "human immunodeficiency virus type 1 HIV1", "human immunodeficiency virus type 1, HIV-1", "human immunodeficiency virus type I HIV-1", "human immunodeficiency virus type-1 HIV-1", "human immunodeficiency virus-1 HIV-1" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Human immunodeficiency virus 1" ; rdfs:subClassOf obo:NCBITaxon_11646 . obo:NCBITaxon_11709 obo:IAO_0000111 "Human immunodeficiency virus 2" ; obo:IAO_0000118 "HIV type 2", "Human immunodeficiency virus type 2", "Human immunodeficiency virus-2", "human immunodeficiency virus type 2 HIV-2", "human immunodeficiency virus type 2, HIV-2" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Human immunodeficiency virus 2" ; rdfs:subClassOf obo:NCBITaxon_11646 . obo:NCBITaxon_117571 obo:IAO_0000111 "Euteleostomi" ; obo:IAO_0000118 "bony vertebrates" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Euteleostomi" ; rdfs:subClassOf obo:NCBITaxon_7742 . obo:NCBITaxon_1206794 obo:IAO_0000111 "Ecdysozoa" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Ecdysozoa" ; rdfs:subClassOf obo:NCBITaxon_33213 . obo:NCBITaxon_12637 obo:IAO_0000111 "Dengue virus" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Dengue virus" ; rdfs:subClassOf obo:NCBITaxon_11050 . obo:NCBITaxon_160 obo:IAO_0000111 "Treponema pallidum" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Treponema pallidum" ; rdfs:subClassOf obo:NCBITaxon_2 . obo:NCBITaxon_197562 obo:IAO_0000111 "Pancrustacea" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Pancrustacea" ; rdfs:subClassOf obo:NCBITaxon_6656 . obo:NCBITaxon_2 obo:IAO_0000111 "Bacteria" ; obo:IAO_0000118 "eubacteria" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Bacteria" ; rdfs:subClassOf obo:OBI_0100026 . obo:NCBITaxon_2157 obo:IAO_0000111 "Archaea" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Archaea" ; rdfs:subClassOf obo:OBI_0100026 . obo:NCBITaxon_2559587 obo:IAO_0000111 "Riboviria" ; obo:IAO_0000118 "RNA viruses", "RNA viruses and viroids" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Riboviria" ; rdfs:subClassOf obo:NCBITaxon_10239 . obo:NCBITaxon_2732406 obo:IAO_0000111 "Kitrinoviricota" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Kitrinoviricota" ; rdfs:subClassOf obo:NCBITaxon_2559587 . obo:NCBITaxon_2732514 obo:IAO_0000111 "Revtraviricetes" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Revtraviricetes" ; rdfs:subClassOf obo:NCBITaxon_2559587 . obo:NCBITaxon_2759 obo:IAO_0000111 "Eukaryota" ; obo:IAO_0000118 "eucaryotes", "eukaryotes" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Eukaryota" ; rdfs:subClassOf obo:OBI_0100026 . obo:NCBITaxon_314146 obo:IAO_0000111 "Euarchontoglires" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Euarchontoglires" ; rdfs:subClassOf obo:NCBITaxon_40674 . obo:NCBITaxon_32523 obo:IAO_0000111 "Tetrapoda" ; obo:IAO_0000118 "tetrapods" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Tetrapoda" ; rdfs:subClassOf obo:NCBITaxon_117571 . obo:NCBITaxon_32524 obo:IAO_0000111 "Amniota" ; obo:IAO_0000118 "amniotes" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Amniota" ; rdfs:subClassOf obo:NCBITaxon_32523 . obo:NCBITaxon_33154 obo:IAO_0000111 "Opisthokonta" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Opisthokonta" ; rdfs:subClassOf obo:NCBITaxon_2759 . obo:NCBITaxon_33208 obo:IAO_0000111 "Metazoa" ; obo:IAO_0000118 "metazoans", "multicellular animals" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Metazoa" ; rdfs:subClassOf obo:NCBITaxon_33154 . obo:NCBITaxon_33213 obo:IAO_0000111 "Bilateria" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Bilateria" ; rdfs:subClassOf obo:NCBITaxon_33208 . obo:NCBITaxon_3702 obo:IAO_0000111 "Arabidopsis thaliana" ; obo:IAO_0000118 "mouse-ear cress", "thale cress", "thale-cress" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Arabidopsis thaliana" ; rdfs:subClassOf obo:NCBITaxon_2759 . obo:NCBITaxon_37124 obo:IAO_0000111 "Chikungunya virus" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Chikungunya virus" ; rdfs:subClassOf obo:NCBITaxon_2732406 . obo:NCBITaxon_388799 obo:IAO_0000111 "HIV-1 group O" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "HIV-1 group O" ; rdfs:subClassOf obo:NCBITaxon_11676 . obo:NCBITaxon_39107 obo:IAO_0000111 "Murinae" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Murinae" ; rdfs:subClassOf obo:NCBITaxon_9989 . obo:NCBITaxon_40674 obo:IAO_0000111 "Mammalia" ; obo:IAO_0000118 "mammals" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Mammalia" ; rdfs:subClassOf obo:NCBITaxon_32524 . obo:NCBITaxon_44689 obo:IAO_0000111 "Dictyostelium discoideum" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Dictyostelium discoideum" ; rdfs:subClassOf obo:NCBITaxon_2759 . obo:NCBITaxon_4890 obo:IAO_0000111 "Ascomycota" ; obo:IAO_0000118 "ascomycetes", "sac fungi" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Ascomycota" ; rdfs:subClassOf obo:NCBITaxon_33154 . obo:NCBITaxon_4896 obo:IAO_0000111 "Schizosaccharomyces pombe" ; obo:IAO_0000118 "fission yeast" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Schizosaccharomyces pombe" ; rdfs:subClassOf obo:NCBITaxon_4890 . obo:NCBITaxon_4932 obo:IAO_0000111 "Saccharomyces cerevisiae" ; obo:IAO_0000118 "S. cerevisiae", "baker's yeast", "brewer's yeast" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Saccharomyces cerevisiae" ; rdfs:subClassOf obo:NCBITaxon_716545 . obo:NCBITaxon_5140 obo:IAO_0000111 "Neurospora" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Neurospora" ; rdfs:subClassOf obo:NCBITaxon_716545 . obo:NCBITaxon_5820 obo:IAO_0000111 "Plasmodium" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Plasmodium" ; rdfs:subClassOf obo:NCBITaxon_2759 . obo:NCBITaxon_6239 obo:IAO_0000111 "Caenorhabditis elegans" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Caenorhabditis elegans" ; rdfs:subClassOf obo:NCBITaxon_1206794 . obo:NCBITaxon_6656 obo:IAO_0000111 "Arthropoda" ; obo:IAO_0000118 "arthropods" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Arthropoda" ; rdfs:subClassOf obo:NCBITaxon_1206794 . obo:NCBITaxon_6668 obo:IAO_0000111 "Daphnia" ; obo:IAO_0000118 "common water fleas" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Daphnia" ; rdfs:subClassOf obo:NCBITaxon_197562 . obo:NCBITaxon_7147 obo:IAO_0000111 "Diptera" ; obo:IAO_0000118 "flies" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Diptera" ; rdfs:subClassOf obo:NCBITaxon_197562 . obo:NCBITaxon_7157 obo:IAO_0000111 "Culicidae" ; obo:IAO_0000118 "mosquitos" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Culicidae" ; rdfs:subClassOf obo:NCBITaxon_7147 . obo:NCBITaxon_716545 obo:IAO_0000111 "saccharomyceta" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "saccharomyceta" ; rdfs:subClassOf obo:NCBITaxon_4890 . obo:NCBITaxon_7227 obo:IAO_0000111 "Drosophila melanogaster" ; obo:IAO_0000118 "fruit fly" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Drosophila melanogaster" ; rdfs:subClassOf obo:NCBITaxon_7147 . obo:NCBITaxon_7742 obo:IAO_0000111 "Vertebrata " ; obo:IAO_0000118 "Vertebrata", "vertebrates" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Vertebrata " ; rdfs:subClassOf obo:NCBITaxon_33213 . obo:NCBITaxon_784 obo:IAO_0000111 "Orientia tsutsugamushi" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Orientia tsutsugamushi" ; rdfs:subClassOf obo:NCBITaxon_2 . obo:NCBITaxon_7955 obo:IAO_0000111 "Danio rerio" ; obo:IAO_0000118 "leopard danio", "zebra danio", "zebra fish", "zebrafish" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Danio rerio" ; rdfs:subClassOf obo:NCBITaxon_117571 . obo:NCBITaxon_8353 obo:IAO_0000111 "Xenopus " ; obo:IAO_0000118 "Xenopus" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Xenopus " ; rdfs:subClassOf obo:NCBITaxon_32523 . obo:NCBITaxon_9031 obo:IAO_0000111 "Gallus gallus" ; obo:IAO_0000118 "Gallus domesticus", "bantam", "chicken", "chickens" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Gallus gallus" ; rdfs:subClassOf obo:NCBITaxon_32524 . obo:NCBITaxon_9606 obo:IAO_0000111 "Homo sapiens" ; obo:IAO_0000118 "human", "human being" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Homo sapiens" ; rdfs:subClassOf obo:NCBITaxon_314146 . obo:NCBITaxon_9989 obo:IAO_0000111 "Rodentia" ; obo:IAO_0000118 "rodent" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Rodentia" ; rdfs:subClassOf obo:NCBITaxon_314146 . obo:OBA_0000001 obo:IAO_0000111 "biological attribute" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "biological attribute" ; rdfs:subClassOf obo:BFO_0000019 . obo:OBA_2060180 obo:IAO_0000111 "limb coordination efficacy" ; obo:IAO_0000115 "The process efficacy of a limb coordination." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "limb coordination efficacy" ; rdfs:subClassOf obo:OBA_0000001 . obo:OBA_2060181 obo:IAO_0000111 "upper limb coordination efficacy" ; obo:IAO_0000115 "The process efficacy of a upper limb coordination." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "upper limb coordination efficacy" ; rdfs:subClassOf obo:OBA_2060180 . obo:OBA_2060182 obo:IAO_0000111 "lower limb coordination efficacy" ; obo:IAO_0000115 "The process efficacy of a lower limb coordination." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "lower limb coordination efficacy" ; rdfs:subClassOf obo:OBA_2060180 . obo:OBA_2060184 obo:IAO_0000111 "whole organism stability" ; obo:IAO_0000115 "The stability of a multicellular organism." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "whole organism stability" ; rdfs:subClassOf obo:OBA_0000001 . obo:OBA_2060185 obo:IAO_0000111 "facial muscle performance" ; obo:IAO_0000115 "The functionality of a facial muscle." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "facial muscle performance" ; rdfs:subClassOf obo:OBA_0000001 . obo:OBA_2060186 obo:IAO_0000111 "peripheral nervous system function" ; obo:IAO_0000115 "The functionality of a peripheral nervous system." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "peripheral nervous system function" ; rdfs:subClassOf obo:OBA_0000001 . obo:OBA_2060187 obo:IAO_0000111 "knee joint functionality" ; obo:IAO_0000115 "The functionality of a knee joint." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "knee joint functionality" ; rdfs:subClassOf obo:OBA_0000001 . obo:OBA_2060188 obo:IAO_0000111 "ankle joint functionality" ; obo:IAO_0000115 "The functionality of a ankle joint." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ankle joint functionality" ; rdfs:subClassOf obo:OBA_0000001 . obo:OBA_2060189 obo:IAO_0000111 "tendon of biceps brachii functionality" ; obo:IAO_0000115 "The functionality of a tendon of biceps brachii." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "tendon of biceps brachii functionality" ; rdfs:subClassOf obo:OBA_0000001 . obo:OBA_2060190 obo:IAO_0000111 "brachioradialis functionality" ; obo:IAO_0000115 "The functionality of a brachioradialis." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "brachioradialis functionality" ; rdfs:subClassOf obo:OBA_0000001 . obo:OBI_0000006 obo:IAO_0000111 "role of being consumer safety officer" ; obo:IAO_0000112 "Consumer safety officer; Consumer Safety Officer Positions at FDA http://69.20.19.211/jobs/cso.htm"@en, "Person charged with serving as CSO, FDA official who coordinates the review"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "the role of a human being that is realized by enforcing regulations to ensure consumer safety" ; obo:IAO_0000117 "Jennifer Fostel"@en, "Person:Helen Parkinson" ; obo:IAO_0000119 "OBI, CDISC"@en ; a owl:Class ; rdfs:label "role of being consumer safety officer"@en ; rdfs:subClassOf obo:OBI_0000273 . obo:OBI_0000010 obo:IAO_0000111 "fluorescent reporter intensity"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A measurement datum that represents the output of a scanner measuring the intensity value for each fluorescent reporter."@en ; obo:IAO_0000117 "person:Chris Stoeckert"@en ; obo:IAO_0000119 "group:OBI" ; obo:IAO_0000232 "From the DT branch: This term and definition were originally submitted by the community to our branch, but we thought they best fit DENRIE. However we see several issues with this. First of all the name 'probe' might not be used in OBI. Instead we have a 'reporter' role. Also, albeit the term 'probe intensity' is often used in communities such as the microarray one, the name 'probe' is ambiguous (some use it to refer to what's on the array, some use it to refer to what's hybed to the array). Furthermore, this concept could possibly be encompassed by combining different OBI terms, such as the roles of analyte, detector and reporter (you need something hybed to a probe on the array to get an intensity) and maybe a more general term for 'measuring intensities'. We need to find the right balance between what is consistent with OBI and combinations of its terms and what is user-friendly. Finally, note that 'intensity' is already in the OBI .owl file and is also in PATO. Why didn't OBI import it from PATO? This might be a problem."@en ; a owl:Class ; rdfs:label "fluorescent reporter intensity"@en ; rdfs:subClassOf obo:IAO_0000109 . obo:OBI_0000011 obo:IAO_0000111 "planned process", "planned process"@en ; obo:IAO_0000112 "Injecting mice with a vaccine in order to test its efficacy" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process that realizes a plan which is the concretization of a plan specification."@en ; obo:IAO_0000116 "'Plan' includes a future direction sense. That can be problematic if plans are changed during their execution. There are however implicit contingencies for protocols that an agent has in his mind that can be considered part of the plan, even if the agent didn't have them in mind before. Therefore, a planned process can diverge from what the agent would have said the plan was before executing it, by adjusting to problems encountered during execution (e.g. choosing another reagent with equivalent properties, if the originally planned one has run out.)", """We are only considering successfully completed planned processes. A plan may be modified, and details added during execution. For a given planned process, the associated realized plan specification is the one encompassing all changes made during execution. This means that all processes in which an agent acts towards achieving some objectives is a planned process.""" ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "branch derived" ; obo:IAO_0000232 "6/11/9: Edited at workshop. Used to include: is initiated by an agent", "This class merges the previously separated objective driven process and planned process, as they the separation proved hard to maintain. (1/22/09, branch call)"@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "planned process"@en ; rdfs:subClassOf obo:BFO_0000015 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000059 ; owl:someValuesFrom obo:IAO_0000104 ] ] . obo:OBI_0000014 obo:IAO_0000111 "regulator role" ; obo:IAO_0000112 "Fact sheet - Regulating the companies The role of the regulator. Ofwat is the economic regulator of the water and sewerage industry in England and Wales. http://www.ofwat.gov.uk/aptrix/ofwat/publish.nsf/Content/roleofregulator_factsheet170805"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a regulatory role involved with making and/or enforcing relevant legislation and governmental orders"@en ; obo:IAO_0000117 "Person:Jennifer Fostel"@en ; obo:IAO_0000118 "regulator" ; obo:IAO_0000119 "OBI"@en ; a owl:Class ; rdfs:label "regulator role"@en ; rdfs:subClassOf obo:OBI_0000017 . obo:OBI_0000015 obo:IAO_0000111 "biological feature identification objective"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Biological_feature_identification_objective is an objective role carried out by the proposition defining the aim of a study designed to examine or characterize a particular biological feature."@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; a owl:Class ; rdfs:label "biological feature identification objective"@en ; rdfs:subClassOf obo:IAO_0000005 . obo:OBI_0000016 obo:IAO_0000111 "regulation-assigned role"@en ; obo:IAO_0000112 "Approval letter"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Regulation-assigned role is a regulatory role defined by legislation or governmental orders"@en ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; a owl:Class ; rdfs:label "regulation-assigned role"@en ; rdfs:subClassOf obo:OBI_0000017 . obo:OBI_0000017 obo:IAO_0000111 "regulatory role"@en ; obo:IAO_0000112 "Regulatory agency, Ethics committee, Approval letter; example: Browse these EPA Regulatory Role subtopics http://www.epa.gov/ebtpages/enviregulatoryrole.html Feb 29, 2008"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a role which inheres in material entities and is realized in the processes of making, enforcing or being defined by legislation or orders issued by a governmental body."@en ; obo:IAO_0000117 "GROUP: Role branch"@en ; obo:IAO_0000119 "OBI, CDISC"@en ; obo:IAO_0000232 "govt agents responsible for creating regulations; proxies for enforcing regulations. CDISC definition: regulatory authorities. Bodies having the power to regulate. NOTE: In the ICH GCP guideline the term includes the authorities that review submitted clinical data and those that conduct inspections. These bodies are sometimes referred to as competent"@en ; a owl:Class ; rdfs:label "regulatory role"@en ; rdfs:subClassOf obo:BFO_0000023 . obo:OBI_0000018 obo:IAO_0000111 "material supplier role" ; obo:IAO_0000112 "Jackson Labs is an organization which provide mice as experimental material" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a role realized through the process of supplying materials such as animal subjects, reagents or other materials used in an investigation."@en ; obo:IAO_0000116 "Supplier role is a special kind of service, e.g. biobank" ; obo:IAO_0000117 "PERSON:Jennifer Fostel"@en ; obo:IAO_0000118 "material provider role", "supplier" ; a owl:Class ; rdfs:label "material supplier role"@en ; rdfs:subClassOf obo:OBI_0000947 . obo:OBI_0000020 obo:IAO_0000111 "contract research organization role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a worker role of carrying out the study according to the protocol document or study plan delivered by the PI, under the control of the study director. This role cannot make decisions about the study execution"@en ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "contract research organization" ; a owl:Class ; rdfs:label "contract research organization role"@en ; rdfs:subClassOf obo:OBI_0000116 . obo:OBI_0000021 obo:IAO_0000111 "list-mode data file"@en ; obo:IAO_0000112 "An example of a list-mode data file is a file following list-mode Flow Cytometry Standard (FCS) format. Since FCS files can be in histogram mode or list-mode we have to specify which data format specifically. List-mode format in the overwhelming (even universal) option used."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A list-mode data file is a binary digital entity where events are stored sequentially, parameter by parameter."@en ; obo:IAO_0000116 "One example of usage is in the context of flow cytometry, however is not restricted to this community and is more widely used, e.g. by imaging people."@en ; obo:IAO_0000117 "person:Chris Stoeckert"@en ; obo:IAO_0000119 "group:Flow Cytometry community" ; a owl:Class ; rdfs:label "list-mode data file"@en ; rdfs:subClassOf obo:IAO_0000030 . obo:OBI_0000023 obo:IAO_0000111 "classified data set" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A data set that is produced as the output of a class prediction data transformation and consists of a data set with assigned class labels."@en ; obo:IAO_0000117 "PERSON: James Malone", "PERSON: Monnie McGee" ; obo:IAO_0000118 "data set with assigned class labels" ; a owl:Class ; rdfs:label "classified data set"@en ; rdfs:subClassOf obo:IAO_0000100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000663 ] . obo:OBI_0000025 obo:IAO_0000111 "reference substance role" ; obo:IAO_0000112 "Calibration standard, positive control substance, vehicle Good Laboratory Practices: Questions and Answers - Test Control and Reference Substance Characterization http://www.epa.gov/enforcement/monitoring/programs/fifra/glpqanda-character.html"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a role inhering in a material entity that is realized when characteristics or responses elicited by the substance are used for comparison or reference."@en ; obo:IAO_0000117 "Person:Jennifer Fostel"@en ; obo:IAO_0000118 "reference substance" ; obo:IAO_0000119 "OBI"@en ; a owl:Class ; rdfs:label "reference substance role"@en ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:BFO_0000040 ] . obo:OBI_0000026 obo:IAO_0000111 "cytological stain role" ; obo:IAO_0000112 "haemotoxylin is a general purpose nuclear stain extracted from the wood of the logwood tree WEB: http://en.wikipedia.org/wiki/Haematoxylin" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A dye role that is realized when the stain is used to colour cells and or cellular components for the purposes of visualization" ; obo:IAO_0000117 "Person:Helen Parkinson", "Person:Jennifer Fostel"@en ; obo:IAO_0000118 "cytological stain" ; a owl:Class ; rdfs:label "cytological stain role"@en ; rdfs:subClassOf obo:OBI_0000250 . obo:OBI_0000029 obo:IAO_0000111 "centrifuge pellet role" ; obo:IAO_0000112 "Definition of pellet :the material concentrated at the bottom of a centrifuge tube after centrifugation. http://www.everythingbio.com/glos/definition.php?word=pellet" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "pellet role is a role which inheres in a material entity and is realized by a material separation process using gravitational force generated by a centrifuge in which the material bearing the pellet role is the heavier or heaviest component of the output material.."@en ; obo:IAO_0000117 "GROUP: Role branch" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000232 "9Mar09 after discussion with process branch changed definition to include use of centrifuge;" ; a owl:Class ; rdfs:label "centrifuge pellet role"@en ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:BFO_0000040 ], [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0302886 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000032 obo:IAO_0000111 "clinical research coordinator role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a worker role comprised of handling the administrative duties of a trial or study."@en ; obo:IAO_0000117 "Person:Jennifer Fostel"@en ; obo:IAO_0000118 "clinical research coordinator" ; a owl:Class ; rdfs:label "clinical research coordinator role"@en ; rdfs:subClassOf obo:OBI_0000116 . obo:OBI_0000034 obo:IAO_0000111 "supernatant role" ; obo:IAO_0000112 "Precipitation is the formation of a solid in a solution during a chemical reaction. When the reaction occurs, the solid formed is called the precipitate, and the liquid remaining above the solid is called the supernate. Wikipedia" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "supernatant role is a role which inheres in a material entity and is realized by a material separation process using gravitational force in which the material bearing the supernatant role is the liquid component of the output material." ; obo:IAO_0000117 "GROUP: Role branch" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "supernatant role"@en ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:BFO_0000040 ], [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0600014 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000038 obo:IAO_0000111 "chromatography column" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Chromatography column in chemistry is a tube and contents (typically glass) used to purify individual chemical compounds from mixtures of compounds. It is often used for preparative applications on scales from micrograms up to kilograms." ; obo:IAO_0000117 "Frank Gibson" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Column_chromatography" ; obo:IAO_0000232 "open tracker https://sourceforge.net/tracker/index.php?func=detail&aid=2881353&group_id=177891&atid=886178" ; a owl:Class ; rdfs:label "chromatography column" ; rdfs:subClassOf obo:OBI_0000932, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000967 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000372 [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0600046 ; owl:onProperty obo:BFO_0000054 ] ) ] ] . obo:OBI_0000040 obo:IAO_0000111 "drug role"@en ; obo:IAO_0000112 """http://www.answers.com/topic/drug 1. A substance used in the diagnosis, treatment, or prevention of a disease or as a component of a medication. 2. Such a substance as recognized or defined by the U.S. Food, Drug, and Cosmetic Act.""" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a role borne by a molecular entity and is realized in a process of absorption by an organism alters, or effects (or is assumed to effect) a function(s) which inhere in an organism"@en ; obo:IAO_0000117 "Role Branch"@en ; obo:IAO_0000118 "drug" ; obo:IAO_0000119 "OBI, CDISC"@en ; a owl:Class ; rdfs:label "drug role"@en ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_23367 ] . obo:OBI_0000041 obo:IAO_0000111 "pump valve switch" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A pump valve switch is a cardinal part of a liquid chromatography instrument that controls the flow." ; obo:IAO_0000116 "FG:I would assume this should be a pump valve control switch and it would not be specific to a liquid chromatography instrument" ; obo:IAO_0000117 "OBI Instrument branch" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "pump valve switch" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0000043 obo:IAO_0000111 "xenotransplantation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "is the transplantation of living cells, tissues or \\norgans from one species to another such as from pigs to humans"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "xenotransplantation"@en ; rdfs:subClassOf obo:OBI_0000105 . obo:OBI_0000044 obo:IAO_0000111 "physical document"@en ; obo:IAO_0000112 "a book is a physical document"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A physical document is an object serving as a record of information by means of symbolic marks."@en ; obo:IAO_0000117 "PERSON: Bjoern Peters" ; obo:IAO_0000119 "GROUP: OBI" ; a owl:Class ; rdfs:label "physical document"@en ; rdfs:subClassOf obo:OBI_0000047 . obo:OBI_0000045 obo:IAO_0000111 "waiting"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A planned process where an agent does not take any new actions towards a particular objective for a period of time until a set of conditions is met."@en ; obo:IAO_0000117 "PERSON:Alan Ruttenberg"@en ; obo:IAO_0000119 "OBI branch derived"@en ; obo:IAO_0000232 "BP: I have doubts about the utility of this."@en, "We need a better handling/modeling of time (January 2008)"@en ; a owl:Class ; rdfs:label "waiting"@en ; rdfs:subClassOf obo:OBI_0600009 . obo:OBI_0000047 obo:IAO_0000111 "processed material"@en ; obo:IAO_0000112 "Examples include gel matrices, filter paper, parafilm and buffer solutions, mass spectrometer, tissue samples"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "Is a material entity that is created or changed during material processing."@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en ; a owl:Class ; rdfs:label "processed material"@en ; rdfs:subClassOf obo:BFO_0000040 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000094 ] ) ] . obo:OBI_0000048 obo:IAO_0000111 "chromatography device" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that facilitates the separation of mixtures. The function of a chromatography device involves passing a mixture dissolved in a \"mobile phase\" through a stationary phase, which separates the analyte to be measured from other molecules in the mixture and allows it to be isolated." ; obo:IAO_0000117 "Frank Gibson" ; obo:IAO_0000118 "chromatography instrument" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Chromatography" ; obo:IAO_0000232 "open tracker https://sourceforge.net/tracker/index.php?func=detail&aid=2881353&group_id=177891&atid=886178" ; a owl:Class ; rdfs:label "chromatography device" ; rdfs:subClassOf obo:OBI_0000832, obo:OBI_0000932, obo:OBI_0002089, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000370 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000372 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000401 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000049 obo:IAO_0000111 "mass spectrometer" ; obo:IAO_0000112 "LCQ Fleet Ion Trap MSn manufactured by thermo fisher scientific" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A mass spectrometer is an instrument which is used to measure the mass to charge ratio of ions. All mass spectrometers consist of three basic parts: an ion source, a mass analyzer, and a detector system. The stages within the mass spectrometer are: 1. Production of ions from the sample 2. Separation of ions with different masses 3. Detection of the number of ions of each mass produced 4.Collection of data to generate the mass spectrum" ; obo:IAO_0000117 "Frank Gibson" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Mass_spectrometry" ; a owl:Class ; rdfs:label "mass spectrometer" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000345 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000361 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000364 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000050 obo:IAO_0000111 "obsolete_platform" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A platform is an object_aggregate that is the set of instruments and software needed to perform a process. definition_source: OBI." ; obo:IAO_0000117 "OBI Instrument branch" ; obo:IAO_0000119 "OBI Instrument branch" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_platform" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000051 obo:IAO_0000111 "liquid chromatography mass spectrometry platform" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A liquid chromatography mass spectrometry platform is a platform that is the collection of instrument, software and reagents needed to perform a liquid chromatography mass spectrometry protocol. definition_source: OBI." ; obo:IAO_0000117 "OBI instrument branch" ; obo:IAO_0000119 "OBI Instrument branch" ; a owl:Class ; rdfs:label "liquid chromatography mass spectrometry platform" ; rdfs:subClassOf obo:OBI_0000832, obo:OBI_0000932, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000048 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000049 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000372 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000052 obo:IAO_0000111 "microarray platform" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A microarray platform is a platform that contains the instruments, software and reagents needed to perform a microarray protocol. definition_source: OBI." ; obo:IAO_0000117 "OBI Instrument branch" ; obo:IAO_0000119 "OBI Instrument branch" ; a owl:Class ; rdfs:label "microarray platform" ; rdfs:subClassOf obo:OBI_0001034, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0400147 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000401 ] . obo:OBI_0000054 obo:IAO_0000111 "ratio of collected to emitted light"@en ; obo:IAO_0000112 "10%"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A measurement datum measuring the amount of light collected s compared to the total amount of emitted light in the detector component of a flow cytometer instrument. The datum has a qualitative role"@en ; obo:IAO_0000117 "person:Chris Stoeckert"@en, "person:Kevin Clancy"@en ; obo:IAO_0000119 "Submitted by the Flow Cytometry community in DigitalEntity-FlowCytometry-2007-03-30.txt" ; a owl:Class ; rdfs:label "ratio of collected to emitted light"@en ; rdfs:subClassOf obo:IAO_0000109 . obo:OBI_0000055 obo:IAO_0000111 "software optimization objective"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Software_optimization is a software_testing_objective role describing a study designed to identify the best software or parameters of the software."@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; a owl:Class ; rdfs:label "software optimization objective"@en ; rdfs:subClassOf obo:OBI_0000242 . obo:OBI_0000056 obo:IAO_0000111 "notified body role" ; obo:IAO_0000112 "The role of notified bodies presentation: http://ec.europa.eu/enterprise/electr_equipment/emc/revision/notified_bodies.pdf"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Notified body is regulator of consumables and medical devices charged by the Competent Authority with verifying compliance of medical devices (not drugs) with the applicable Essential Requirements stated in the Medical Device Directive"@en ; obo:IAO_0000116 "Notified Body (NB). A private institution charged by the Competent Authority with verifying compliance of medical devices (not drugs) with the applicable Essential Requirements stated in the Medical Device Directive. This process, called Conformity Assessment, has EU-wide validity once completed by the NB."@en ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "notified body" ; obo:IAO_0000119 "OBI, CDISC"@en ; a owl:Class ; rdfs:label "notified body role"@en ; rdfs:subClassOf obo:OBI_0000273 . obo:OBI_0000057 obo:IAO_0000111 "allotransplantation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "is the transplantation of organs between members of the same species."@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "allotransplantation"@en ; rdfs:subClassOf obo:OBI_0000105 . obo:OBI_0000059 obo:IAO_0000111 "gamma counter" ; obo:IAO_0000112 "A Geiger counter" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A processed material which measures gamma radiation" ; obo:IAO_0000117 "Frank Gibson" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Gamma_counter" ; a owl:Class ; rdfs:label "gamma counter" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000060 obo:IAO_0000111 "trial monitor role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a responsible party involved in planning, overseeing the conduct of a study or study component, and interpreting data from a study"@en ; obo:IAO_0000117 "Person:Jennifer Fostel"@en ; obo:IAO_0000118 "trial monitor" ; obo:IAO_0000232 "CDISC definition: Person employed by the sponsor or CRO who is responsible for determining that a trial is being conducted in accordance with the protocol and GCP guidance. NOTE: A monitor's duties may include, but are not limited to, helping to plan and initiate a trial, assessing the conduct of trials, and assisting in data analysis, interpretation and extrapolation. Clinical Research Associate: Primary representative of the sponsor; monitors progress of investigator sites participating in a clinical study."@en ; a owl:Class ; rdfs:label "trial monitor role"@en ; rdfs:subClassOf obo:OBI_0000102 . obo:OBI_0000064 obo:IAO_0000111 "positive reference substance role" ; obo:IAO_0000112 "MMS mutagen"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a reference role in which the characteristics or responses elicited by the substance playing the reference substance role are used to establish a \"100%\" response" ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "positive reference substance" ; a owl:Class ; rdfs:label "positive reference substance role"@en ; rdfs:subClassOf obo:OBI_0000025, [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0000070 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000065 obo:IAO_0000111 "polyethylene glycol p-(1,1,3,3-tetramethylbutyl)-phenyl ether"@en ; obo:IAO_0000112 "PMID: 30799. J Histochem Cytochem. 1978 Sep;26(9):696-712. Acid lipase: a histochemical and biochemical study using triton X100-naphtyl palmitate micelles."@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "triton X100 is a chemical entity which belongs to the group of The pluronics which are triblock copolymers of ethylene oxide and propylene oxide. Triton x-100 is_used_as detergent due to its non-ionic surfactant properties"@en ; obo:IAO_0000117 "Philippe Rocca-Serra"@en ; obo:IAO_0000119 "adapted from Wikipedia before possible import from CHEBI"@en ; a owl:Class ; rdfs:label "polyethylene glycol p-(1,1,3,3-tetramethylbutyl)-phenyl ether"@en ; rdfs:subClassOf obo:CHEBI_23367 . obo:OBI_0000066 obo:IAO_0000111 "investigation"@en ; obo:IAO_0000112 "Lung cancer investigation using expression profiling, a stem cell transplant investigation, biobanking is not an investigation, though it may be part of an investigation" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "a planned process that consists of parts: planning, study design execution, documentation and which produce conclusion(s)."@en ; obo:IAO_0000117 "Bjoern Peters"@en ; obo:IAO_0000119 "OBI branch derived"@en ; obo:IAO_0000232 "Could add specific objective specification", """Following OBI call November 2012,26th: it was decided there was no need for adding \"achieves objective of drawing conclusion\" as existing relations were providing equivalent ability. this note closes the issue and validates the class definition to be part of the OBI core editor = PRS"""@en ; obo:IAO_0000412 ; obo:OBI_0001847 "study" ; a owl:Class ; rdfs:label "investigation"@en ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000572 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000338 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000471 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000339 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0500000 ] ) ] ] . obo:OBI_0000067 obo:IAO_0000111 "evaluant role"@en ; obo:IAO_0000112 "When a specimen of blood is assayed for glucose concentration, the blood has the evaluant role. When measuring the mass of a mouse, the evaluant is the mouse. When measuring the time of DNA replication, the evaluant is the DNA. When measuring the intensity of light on a surface, the evaluant is the light source."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "a role that inheres in a material entity that is realized in an assay in which data is generated about the bearer of the evaluant role"@en ; obo:IAO_0000116 "Role call - 17nov-08: JF and MC think an evaluant role is always specified input of a process. Even in the case where we have an assay taking blood as evaluant and outputting blood, the blood is not the specified output at the end of the assay (the concentration of glucose in the blood is)"@en, "examples of features that could be described in an evaluant: quality.... e.g. \"contains 10 pg/ml IL2\", or \"no glucose detected\")"@en ; obo:IAO_0000117 "GROUP: Role Branch" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000232 "Feb 10, 2009. changes after discussion at OBI Consortium Workshop Feb 2-6, 2009. accepted as core term." ; a owl:Class ; rdfs:label "evaluant role"@en ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:BFO_0000040 ], [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0000070 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000068 obo:IAO_0000111 "reporting party role" ; obo:IAO_0000112 "Person who prepares microarray data in MAGE-TAB format and submits to a database, such as ArrayExpress.", "The first section has been pre-designated as the 'Reporting Party' section and should be filled with the Reporting Party's personal information. http://www.mercedsheriff.com/SelfReporting.htm"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a study personnel role played by a party who reports the outcome of a study component"@en ; obo:IAO_0000116 "MO:submitter mapped to this term. So, alternative term 'submitter' was added." ; obo:IAO_0000117 "Jennifer Fostel"@en ; obo:IAO_0000118 "reporting party", "submitter" ; obo:IAO_0000119 "OBI"@en ; a owl:Class ; rdfs:label "reporting party role"@en ; rdfs:subClassOf obo:OBI_0000202 . obo:OBI_0000070 obo:IAO_0000111 "assay"@en ; obo:IAO_0000112 "Assay the wavelength of light emitted by excited Neon atoms. Count of geese flying over a house." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A planned process that has the objective to produce information about a material entity (the evaluant) by examining it."@en ; obo:IAO_0000116 "12/3/12: BP: the reference to the 'physical examination' is included to point out that a prediction is not an assay, as that does not require physical examiniation.", "Discussion on OBI call 2023-05-01 resulted in an agreement to revise the textual definition of 'assay'. https://github.com/obi-ontology/obi/issues/1683." ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000118 "measuring"@en, "scientific observation"@en ; obo:IAO_0000119 "OBI branch derived"@en ; obo:OBI_0001847 "study assay" ; obo:OBI_9991118 "any method" ; a owl:Class ; rdfs:label "assay"@en ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_0000067 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:IAO_0000027 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] ] ; owl:disjointWith obo:OBI_0000339, obo:OBI_0200000, obo:OBI_0600013 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000441 ] . obo:OBI_0000071 obo:IAO_0000111 "quantitative confidence value"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A data item which is used to indicate the degree of uncertainty about a measurement."@en ; obo:IAO_0000117 "person:Chris Stoeckert"@en ; obo:IAO_0000119 "group:OBI" ; a owl:Class ; rdfs:label "quantitative confidence value"@en ; rdfs:subClassOf obo:IAO_0000027 . obo:OBI_0000073 obo:IAO_0000111 "sample preparation for assay"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A sample_preparation_for_assay is a protocol_application including material_enrollments and biomaterial_transformations. definition_source: OBI."@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000118 "study"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "sample preparation for assay"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0000075 obo:IAO_0000111 "diagnosis textual entity"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "diagnosis is an assessment of a disease or injury, its likely prognosis and treatment."@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; a owl:Class ; rdfs:label "diagnosis textual entity"@en ; rdfs:subClassOf obo:IAO_0000300 . obo:OBI_0000076 obo:IAO_0000111 "unplanned occurrence effecting an investigation" ; obo:IAO_0000112 "Earthquake that destroys the lab, an outside investigator discovering an adverse effect of the reagants used"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a process which is external in origin to the investigation that has an impact on the outcome."@en ; obo:IAO_0000117 "PERSON: Bjoern Peters" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "unplanned occurrence effecting an investigation"@en ; rdfs:subClassOf obo:BFO_0000015 . obo:OBI_0000078 obo:IAO_0000111 "eMedical record"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An eMedical record is a digital document derived from a computer system used primarily for patient care in a clinical setting. Not required to be compliant with requirements of 21 CFR Part 11."@en ; obo:IAO_0000117 "person:Jennifer Fostel"@en ; obo:IAO_0000119 "article-without-pmid-or-doi:CDISCglossary" ; a owl:Class ; rdfs:label "eMedical record"@en ; rdfs:subClassOf obo:IAO_0000030 . obo:OBI_0000079 obo:IAO_0000111 "culture medium" ; obo:IAO_0000112 "A growth medium or culture medium is a substance in which microorganisms or cells can grow. Wikipedia, growth medium, Feb 29, 2008"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "a processed material that provides the needed nourishment for microorganisms or cells grown in vitro." ; obo:IAO_0000116 """changed from a role to a processed material based on on Aug 22, 2011 dev call. Details see the tracker item: http://sourceforge.net/tracker/?func=detail&aid=3325270&group_id=177891&atid=886178 Modification made by JZ.""" ; obo:IAO_0000117 "Person: Jennifer Fostel, Jie Zheng"@en ; obo:IAO_0000119 "OBI"@en ; a owl:Class ; rdfs:label "culture medium"@en ; rdfs:subClassOf obo:OBI_0000047 . obo:OBI_0000083 obo:IAO_0000111 "electronic case report tabulation"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An electronic case report tabulation is a digital document containing tabular data about multiple trial participants which is part of a clinical regulatory submission. An eCRT has the property that it can be audited and compliant with requirements of 21 CFR Part 11 and has format suited to review by regulators."@en ; obo:IAO_0000117 "person:Jennifer Fostel"@en ; obo:IAO_0000119 "CDISC glossary" ; a owl:Class ; rdfs:label "electronic case report tabulation"@en ; rdfs:subClassOf obo:IAO_0000030 . obo:OBI_0000084 obo:IAO_0000111 "polystyrene tube" ; obo:IAO_0000112 "Polystyrene tubes can be used to contain tissue culture cells during centrifgation" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A polystyrene tube is a test tube made of polystyrene" ; obo:IAO_0000117 "PERSON: Chris Stoeckert" ; obo:IAO_0000119 "PERSON: Chris Stoeckert" ; a owl:Class ; rdfs:label "polystyrene tube" ; rdfs:subClassOf obo:OBI_0000836 . obo:OBI_0000086 obo:IAO_0000111 "reagent role" ; obo:IAO_0000112 "Buffer, dye, a catalyst, a solvating agent."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A role inhering in a biological or chemical entity that is intended to be applied in a scientific technique to participate (or have molecular components that participate) in a chemical reaction that facilitates the generation of data about some entity distinct from the bearer, or the generation of some specified material output distinct from the bearer."@en ; obo:IAO_0000117 "PERSON:Matthew Brush"@en ; obo:IAO_0000118 "reagent" ; obo:IAO_0000119 "PERSON:Matthew Brush" ; obo:IAO_0000232 """Feb 10, 2009. changes after discussion at OBI Consortium Workshop Feb 2-6, 2009. accepted as core term. May 28 2013. Updated definition taken from ReO based on discussions initiated in Philly 2011 workshop. Former defnition described a narrower view of reagents in chemistry that restricts bearers of the role to be chemical entities (\"a role played by a molecular entity used to produce a chemical reaction to detect, measure, or produce other substances\"). Updated definition allows for broader view of reagents in the domain of biomedical research to include larger materials that have parts that participate chemically in a molecular reaction or interaction.""" ; a owl:Class ; rdfs:comment """(copied from ReO) Reagents are distinguished from instruments or devices that also participate in scientific techniques by the fact that reagents are chemical or biological in nature and necessarily participate in or have parts that participate in some chemical interaction or reaction during their intended participation in some technique. By contrast, instruments do not participate in a chemical reaction/interaction during the technique. Reagents are distinguished from study subjects/evaluants in that study subjects and evaluants are that about which conclusions are drawn and knowledge is sought in an investigation - while reagents, by definition, are not. It should be noted, however, that reagent and study subject/evaluant roles can be borne by instances of the same type of material entity - but a given instance will realize only one of these roles in the execution of a given assay or technique. For example, taq polymerase can bear a reagent role or an evaluant role. In a DNA sequencing assay aimed at generating sequence data about some plasmid, the reagent role of the taq polymerase is realized. In an assay to evaluate the quality of the taq polymerase itself, the evaluant/study subject role of the taq is realized, but not the reagent role since the taq is the subject about which data is generated. In regard to the statement that reagents are 'distinct' from the specified outputs of a technique, note that a reagent may be incorporated into a material output of a technique, as long as the IDENTITY of this output is distinct from that of the bearer of the reagent role. For example, dNTPs input into a PCR are reagents that become part of the material output of this technique, but this output has a new identity (ie that of a 'nucleic acid molecule') that is distinct from the identity of the dNTPs that comprise it. Similarly, a biotin molecule input into a cell labeling technique are reagents that become part of the specified output, but the identity of the output is that of some modified cell specimen which shares identity with the input unmodified cell specimen, and not with the biotin label. Thus, we see that an important criteria of 'reagent-ness' is that it is a facilitator, and not the primary focus of an investigation or material processing technique (ie not the specified subject/evaluant about which knowledge is sought, or the specified output material of the technique).""" ; rdfs:label "reagent role"@en ; rdfs:subClassOf obo:OBI_0003610 . obo:OBI_0000089 obo:IAO_0000111 "role of regulator of chemical manufacturer" ; obo:IAO_0000112 "EPA; John Mollison is the registrar of chemical products in Tasmania, the body that administers the Act that regulates chemical use in that State. http://www.abc.net.au/rn/science/earth/stories/s1160346.htm"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a regulator involved with making and enforcing legislation and governmental orders relevant to chemical manufacture"@en ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "regulator of chemical manufacture" ; obo:IAO_0000119 "OBI"@en ; a owl:Class ; rdfs:label "role of regulator of chemical manufacturer"@en ; rdfs:subClassOf obo:OBI_0000014 . obo:OBI_0000091 obo:IAO_0000111 "detector reagent role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a role which inheres in a molecular entity and is realized by the process of recording or registering a stimulus." ; obo:IAO_0000116 "19feb2009. not clear we need this term. originally if came from microarrays -- the probes on the array are termed detectors in some instances" ; obo:IAO_0000119 "One that detects, especially a mechanical, electrical, or chemical device that automatically identifies and records or registers a stimulus, such as an environmental change in pressure or temperature, an electric signal, or radiation from a radioactive material. http://www.answers.com/topic/detector 19feb2009" ; a owl:Class ; rdfs:label "detector reagent role"@en ; rdfs:subClassOf obo:BFO_0000023 . obo:OBI_0000092 obo:IAO_0000111 "role of certified IRB professional" ; obo:IAO_0000112 "CIP= Certified IRB Professional; http://acronyms.thefreedictionary.com/Certified+IRB+Professional"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a role of which inheres in a Homo sapiens and realized during administration and oversight of the daily activities of Institutional Review Boards (IRBs) in the USA" ; obo:IAO_0000117 "Person:Helen Parkinson", "Person:Jennifer Fostel"@en ; obo:IAO_0000118 "certified IRB professional" ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Certified_IRB_Professional" ; a owl:Class ; rdfs:label "role of certified IRB professional"@en ; rdfs:subClassOf obo:OBI_0000016 . obo:OBI_0000093 obo:IAO_0000111 "patient role" ; obo:IAO_0000112 "a hospitalized person; a person with controlled diabetes; the patient's role http://www.fertilityjourney.com/testingAndDiagnosis/theRightDoctor/thePatientsRole/index.asp?C=55245395146924652778"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a role which inheres in a person and is realized by the process of being under the care of a physician or health care provider"@en ; obo:IAO_0000117 "GROUP:Role Branch"@en ; obo:IAO_0000118 "patient" ; obo:IAO_0000119 "OBI, CDISC"@en ; obo:IAO_0000232 "CDISC definition: patient. Person under a physician's care for a particular disease or condition. NOTE: A subject in a clinical trial is not necessarily a patient, but a patient in a clinical trial is a subject. See also subject, trial subject, healthy volunteer. Often used interchangeably"@en ; a owl:Class ; rdfs:label "patient role"@en ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NCBITaxon_9606 ] . obo:OBI_0000094 obo:IAO_0000111 "material processing" ; obo:IAO_0000112 "A cell lysis, production of a cloning vector, creating a buffer." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A planned process which results in physical changes in a specified input material"@en ; obo:IAO_0000117 "PERSON: Bjoern Peters"@en, "PERSON: Frank Gibson", "PERSON: Jennifer Fostel", "PERSON: Melanie Courtot", "PERSON: Philippe Rocca Serra" ; obo:IAO_0000118 "material transformation"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "material processing"@en ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000047 ], [ a owl:Restriction ; owl:allValuesFrom obo:BFO_0000040 ; owl:onProperty obo:OBI_0000293 ] ; owl:disjointWith obo:OBI_0600010 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0000096 obo:IAO_0000111 "protocol testing objective"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Protocol_testing_objective is a methodology_testing_objective role describing a study designed to examine the effects of using different protocols."@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; a owl:Class ; rdfs:label "protocol testing objective"@en ; rdfs:subClassOf obo:OBI_0000208 . obo:OBI_0000097 obo:IAO_0000111 "study subject role"@en ; obo:IAO_0000112 """Human subjects in a clinical trial, rats in a toxicogenomics study, tissue cutlures subjected to drug tests, fish observed in an ecotoxicology study. Parasite example: people are infected with a parasite which is then extracted; the particpant under investigation could be the parasite, the people, or a population of which the people are members, depending on the nature of the study. Lake example: a lake could realize this role in an investigation that assays pollution levels in samples of water taken from the lake.""" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A role that is realized through the execution of a study design in which the bearer of the role participates and in which data about that bearer is collected." ; obo:IAO_0000116 "A participant can realize both \"specimen role\" and \"participant under investigation role\" at the same time. However \"participant under investigation role\" is distinct from \"specimen role\", since a specimen could somehow be involved in an investigation without being the thing that is under investigation." ; obo:IAO_0000117 "GROUP: Role Branch"@en ; obo:IAO_0000119 "OBI" ; obo:IAO_0000232 """Following OBI call November 2012,26th: 1. it was decided there was no need for moving the children class and making them siblings of study subject role. 2. it also settles the disambiguation about 'study subject'. This is about the individual participating in the investigation/study, Not the 'topic' (as in 'toxicity study') of the investigation/study This note closes the issue and validates the class definition to be part of the OBI core editor = PRS"""@en ; a owl:Class ; rdfs:label "participant under investigation role"@en ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0000471 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000100 obo:IAO_0000111 "obsolete_role of being first subject treated" ; obo:IAO_0000112 "Rat 1A; first enrolled patient to receive treatment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "First subject treated role is a study subject role borne by the subject realized in the application of the process specified in intervention study design with no previous study subject realizing the role prior in the study" ; obo:IAO_0000117 "Role Branch" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_role of being first subject treated" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000101 obo:IAO_0000111 "measured expression level"@en ; obo:IAO_0000112 "Examples are quantified data from an expression microarray experiment, PCR measurements, etc."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A measurement datum that is the outcome of the quantification of an assay for the activity of a gene, or the number of RNA transcripts."@en ; obo:IAO_0000117 "person:Chris Stoeckert"@en ; obo:IAO_0000119 "OBI Data Transformation branch" ; a owl:Class ; rdfs:label "measured expression level"@en ; rdfs:subClassOf obo:IAO_0000109 . obo:OBI_0000102 obo:IAO_0000111 "responsible party role" ; obo:IAO_0000112 "he THERAPIST has the ability to print a separate statement for the patient and each responsible party. http://www.beaverlog.com/therapist/ez_support/billing/responsible_party_statements.htm"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a study personnel role played by a party who is accountable for the execution of a study component and can make decisions about the conduct of the study"@en ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "responsible party" ; obo:IAO_0000119 "OBI"@en ; a owl:Class ; rdfs:label "responsible party role"@en ; rdfs:subClassOf obo:OBI_0000202 . obo:OBI_0000103 obo:IAO_0000111 "principal investigator role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a responsible party role played by a person responsible for the overall conduct of a study"@en ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "principal investigator" ; obo:IAO_0000232 "CDISC definition: A person responsible for the conduct of the clinical trial at a trial site. If a trial is conducted by a team of individuals at a trial site, the investigator is the responsible leader of the team and may be called the principal investigator. 2. The individual principal investigator. 2. The individual under whose immediate direction the test article is administered or dispensed to, or used involving, a subject, or, in the event of an investigation conducted by a team of individuals, is See also sponsor-investigator.; Leiter der klinischen Prufung.Under the German Drug Law, the physician who is head of the clinical investigation (CDISC): coordinating investigator (CDISC) (also study coordinator, MUSC); sponsor-investigator. An individual who both initiates and conducts, alone or with others, a clinical trial, and under whose immediate direction the investigational product is administered to, dispensed to, or used by a subject.NOTE: The term does not include any person other than an individual, hence not a corporation, agency (CDISC)"@en ; a owl:Class ; rdfs:label "principal investigator role"@en ; rdfs:subClassOf obo:OBI_0000102 . obo:OBI_0000105 obo:IAO_0000111 "transplantation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a protocol application to replace an organ or tissue of an organism"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "transplantation"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0000107 obo:IAO_0000111 "provides_service_consumer_with" ; obo:IAO_0000112 "The provides_service_consumer_with relation links the service to its primary process it provides for the consumer (as opposed to secondary processual parts of a service process such as payment or documentation). For example, a 'DNA sequencing service' provides_service_consumer_with 'DNA sequencing' as the essential process performed by the provider for the client." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A relation between a service and the primary processual part of the service that is performed by the provider for the consumer." ; a owl:ObjectProperty ; rdfs:domain obo:OBI_0001173 ; rdfs:label "provides_service_consumer_with" ; rdfs:subPropertyOf obo:BFO_0000051 . obo:OBI_0000109 obo:IAO_0000111 "obsolete biological vector role" ; obo:IAO_0000112 "1983 Sci. Amer. Jan. 58/2 Plasmids are routinely used as vectors for introducing foreign DNA into bacteria.", "Some epidemiological aspects and vector role of tick infestation on layers in the Faisalabad district (Pakistan). http://journals.cambridge.org/action/displayAbstract;jsessionid=0373164489D00868AEEF2C556EB4FD29.tomcat1?fromPage=online&aid=624280" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a biological vector role is a material to be added role that is realized by the process of transmitting material to the organism that is the target of the transmission." ; obo:IAO_0000117 "GROUP: Role Branch" ; obo:IAO_0000119 "OBI and Wikipedia" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete biological vector role" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000110 obo:IAO_0000111 "pH indicator dye role" ; obo:IAO_0000112 "bromophenol blue has a pH indicator dye role", "phenol red in RPMI; pH=4 indicator dye (also carries reference role)"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "the role of a dye that is realized when the dye is used in an experiment to measure the pH in a material entity" ; obo:IAO_0000117 "Person: Jennifer Fostel"@en, "Person:Helen Parkinson" ; obo:IAO_0000118 "pH indicator dye" ; a owl:Class ; rdfs:label "pH indicator dye role"@en ; rdfs:subClassOf obo:OBI_0000250 . obo:OBI_0000112 obo:IAO_0000111 "specimen role" ; obo:IAO_0000112 "liver section; a portion of a culture of cells; a nemotode or other animal once no longer a subject (generally killed); portion of blood from a patient." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "a role borne by a material entity that is gained during a specimen collection process and that can be realized by use of the specimen in an investigation"@en ; obo:IAO_0000116 "22Jun09. The definition includes whole organisms, and can include a human. The link between specimen role and study subject role has been removed. A specimen taken as part of a case study is not considered to be a population representative, while a specimen taken as representing a population, e.g. person taken from a cohort, blood specimen taken from an animal) would be considered a population representative and would also bear material sample role.", "Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation.", """blood taken from animal: animal continues in study, whereas blood has role specimen. something taken from study subject, leaves the study and becomes the specimen."""@en, """parasite example - when parasite in people we study people, people are subjects and parasites are specimen - when parasite extracted, they become subject in the following study specimen can later be subject."""@en ; obo:IAO_0000117 "GROUP: Role Branch" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "specimen role"@en ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] ) ] ] . obo:OBI_0000113 obo:IAO_0000111 "sequence feature identification objective"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Sequence_feature_identification_objective is a biological_feature_identification_objective role describing a study designed to examine or characterize molecular features exhibited at the level of a macromolecular sequence, e.g. nucleic acid, protein, polysaccharide."@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; a owl:Class ; rdfs:label "sequence feature identification objective"@en ; rdfs:subClassOf obo:OBI_0000015 . obo:OBI_0000115 obo:IAO_0000111 "intervention design" ; obo:IAO_0000112 "PMID: 18208636.Br J Nutr. 2008 Jan 22;:1-11.Effect of vitamin D supplementation on bone and vitamin D status among Pakistani immigrants in Denmark: a randomised double-blinded placebo-controlled intervention study." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An intervention design is a study design in which a controlled process applied to the subjects (the intervention) serves as the independent variable manipulated by the experimentalist. The treatment (perturbation or intervention) defined can be defined as a combination of values taken by independent variable manipulated by the experimentalists are applied to the recruited subjects assigned (possibly by applying specific methods) to treatment groups. The specificity of intervention design is the fact that independent variables are being manipulated and a response of the biological system is evaluated via response variables as monitored by possibly a series of assays." ; obo:IAO_0000117 "Philppe Rocca-Serra" ; obo:IAO_0000119 "OBI branch derived" ; a owl:Class ; rdfs:label "intervention design" ; rdfs:subClassOf obo:OBI_0500000 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0500000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000931 ] ) ] ] ) ] . obo:OBI_0000116 obo:IAO_0000111 "worker role" ; obo:IAO_0000112 "Public sector workers in states that run their own OSHA programs are covered by those states. http://www.osha.gov/as/opa/worker/index.html"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a personnel role played by a party who executes a component of the study plan; this can occur before, during, after or outside the study timeline"@en ; obo:IAO_0000116 "\"executes the study plan\" includes the suppliers and manufacturers of reagents and other materials used in the study" ; obo:IAO_0000117 "Person:Jennifer Fostel"@en ; obo:IAO_0000118 "worker" ; obo:IAO_0000119 "OBI"@en ; a owl:Class ; rdfs:label "worker role"@en ; rdfs:subClassOf obo:OBI_0000202 . obo:OBI_0000117 obo:IAO_0000111 "Bernoulli trial" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An assay where the output data is a datum with one of two values denoting success and failure." ; obo:IAO_0000117 "PlanAndPlannedProcess Branch" ; obo:IAO_0000119 "OBI branch derived" ; a owl:Class ; rdfs:label "Bernoulli trial" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0000118 obo:IAO_0000111 "gene list"@en ; obo:IAO_0000112 "Gene lists may arise from analysis to determine differentially expressed genes, may be collected from the literature for involvement in a particular process or pathway (e.g., inflammation), or may be the input for gene set enrichment analysis."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A data set of the names or identifiers of genes that are the outcome of an analysis or have been put together for the purpose of an analysis."@en ; obo:IAO_0000117 "person:Chris Stoeckert"@en ; obo:IAO_0000119 "group:OBI" ; obo:IAO_0000232 "kind of report. (alan) need to be careful to distinguish from output of a data transformation or calculation. A gene list is a report when it is published as such? Relates to question of whether report is a whole, or whether it can be a part of some other narrative object."@en ; a owl:Class ; rdfs:label "gene list"@en ; rdfs:subClassOf obo:IAO_0000100 . obo:OBI_0000119 obo:IAO_0000111 "number of particles in subset"@en ; obo:IAO_0000112 "500, 200, 0"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A measurement datum measuring the number of subjects in a defined subset in a flow cytometer instrument. The datum has a qualitative role"@en ; obo:IAO_0000117 "person:Kevin Clancy"@en ; obo:IAO_0000119 "Submitted by the Flow Cytometry community in DigitalEntity-FlowCytometry-2007-03-30.txt" ; a owl:Class ; rdfs:label "number of particles in subset"@en ; rdfs:subClassOf obo:IAO_0000109 . obo:OBI_0000124 obo:IAO_0000111 "is_supported_by_data" ; obo:IAO_0000112 "The relation between the conclusion \"Gene tpbA is involved in EPS production\" and the data items produced using two sets of organisms, one being a tpbA knockout, the other being tpbA wildtype tested in polysacharide production assays and analyzed using an ANOVA." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "The relation between a data item and a conclusion where the conclusion is the output of a data interpreting process and the data item is used as an input to that process" ; obo:IAO_0000117 "OBI" ; obo:IAO_0000119 "OBI", "Philly 2011 workshop" ; a owl:ObjectProperty ; rdfs:domain obo:OBI_0001909 ; rdfs:label "is_supported_by_data" ; rdfs:range obo:IAO_0000027 . obo:OBI_0000125 obo:IAO_0000111 "number of lost events electronic"@en ; obo:IAO_0000112 "74, 0, 14 events lost due to data acquisition electronic coincidence."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A measurement datum measuring the number of analysis events lost due to errors in data acquisition electronic coincidence in a flow cytometer instrument. The datum has a qualitative role."@en ; obo:IAO_0000117 "person:Kevin Clancy"@en ; obo:IAO_0000119 "Submitted by the Flow Cytometry community in DigitalEntity-FlowCytometry-2007-03-30.txt" ; a owl:Class ; rdfs:label "number of lost events electronic"@en ; rdfs:subClassOf obo:IAO_0000109 . obo:OBI_0000129 obo:IAO_0000111 "calibration substance role"@en ; obo:IAO_0000112 "pH buffer used to calibrate a pH meter bears a calibration substance role"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A reference substance role that is realized when characteristics or responses elicited by the bearer are used to ensure an instrument is within protocol specification of accuracy or performance" ; obo:IAO_0000117 "Jennifer Fostel"@en ; a owl:Class ; rdfs:label "calibration substance role"@en ; rdfs:subClassOf obo:OBI_0000025, [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0000818 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000131 obo:IAO_0000111 "molecular feature identification objective"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Molecular_feature_identification_objective is a biological_feature_identification_objective role describing a study designed to examine or characterize molecular features of a biological system, e.g. expression profiling, copy number of molecular components, epigenetic modifications."@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; a owl:Class ; rdfs:label "molecular feature identification objective"@en ; rdfs:subClassOf obo:OBI_0000015 . obo:OBI_0000134 obo:IAO_0000111 "hardware testing objective"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Hardware_testing_objective is a methodology_testing_objective role describing a study designed to examine the effects of using different hardware, e.g. scanner."@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; a owl:Class ; rdfs:label "hardware testing objective"@en ; rdfs:subClassOf obo:OBI_0000208 . obo:OBI_0000136 obo:IAO_0000111 "incubator" ; obo:IAO_0000112 "Incubators are used in microbiology for culturing (growing) bacteria and other microorganisms. Incubators in tissue culture rooms are used for culturing stem cells, lymphocytes, skin fibroblasts and other types of cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device in which environmental conditions (light, photoperiod, temperature, humidity, etc.) can be controlled" ; obo:IAO_0000117 "Frank Gibson" ; obo:IAO_0000119 "http://www.medterms.com/script/main/art.asp?articlekey=18426" ; a owl:Class ; rdfs:label "incubator" ; rdfs:subClassOf obo:OBI_0001034, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000401 ] . obo:OBI_0000140 obo:IAO_0000111 "obsolete_label role" ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "Label role is a role which inheres in a material entity and which is realized in a detection of label assay" ; obo:IAO_0000117 "Role Branch" ; obo:IAO_0000118 "label" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000231 obo:IAO_0000228 ; obo:IAO_0100001 obo:OBI_0002743 ; a owl:Class ; rdfs:label "obsolete_label role" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000143 obo:IAO_0000111 "baseline participant role" ; obo:IAO_0000112 "Subject at time = 0; subject before a stress test."@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a reference participant role which is realized by making the reference to qualities at the start of the study or intervention" ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "baseline participant" ; a owl:Class ; rdfs:label "baseline participant role"@en ; rdfs:subClassOf obo:OBI_0000220 . obo:OBI_0000144 obo:IAO_0000111 "role of independent data monitoring committee" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a trial monitor role charged recommending whether to continue, modify, or end the trial"@en ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "independent data monitoring committee" ; a owl:Class ; rdfs:label "role of independent data monitoring committee"@en ; rdfs:subClassOf obo:OBI_0000060 . obo:OBI_0000145 obo:IAO_0000111 "pathologist role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a worker role of being responsible for making the histopathology diagnoses associated with data from a study; this activity occurs outside the study timeline"@en ; obo:IAO_0000117 "Person:Jennifer Fostel"@en ; obo:IAO_0000118 "Pathologist" ; a owl:Class ; rdfs:label "pathologist role"@en ; rdfs:subClassOf obo:OBI_0000116 . obo:OBI_0000146 obo:IAO_0000111 "supernatant collection system harvesting frame" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is designed for collecting 90% of the supernatant in a microplate well and separating the living cell with no stress, eliminating centrifugation and other similar techniques. It can be used in a variety of release assays with different radioactive isotopes, such as Cr51 or I125." ; obo:IAO_0000117 "Daniel Schober" ; obo:IAO_0000119 "google" ; a owl:Class ; rdfs:label "supernatant collection system harvesting frame" ; rdfs:subClassOf obo:OBI_0000967, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000370 ] . obo:OBI_0000151 obo:IAO_0000111 "filter paper" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device manufacture with the intent to provide a porous unsized paper used for filtering." ; obo:IAO_0000117 "Frank Gibson" ; obo:IAO_0000119 "sep:00107" ; a owl:Class ; rdfs:label "filter paper" ; rdfs:subClassOf obo:OBI_0000932, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000378 ] . obo:OBI_0000153 obo:IAO_0000111 "cell co-culturing"@en ; obo:IAO_0000112 "Culturing cytotoxic T-lymphocytes together with target cells in order to study lysis of the target cells. See chromium_release_assay"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A material combination in which cell cultures of two or more different types are are combined and allowed to culture as one."@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "cell co-culturing"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CL_0000000 ] [ a owl:Restriction ; owl:minCardinality "2"^^xsd:nonNegativeInteger ; owl:onProperty obo:OBI_0000293 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000079 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0100060 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0000154 obo:IAO_0000111 "role of Institutional Review Board" ; obo:IAO_0000112 "An institutional review board/independent ethics committee (IRB/IEC) (also known as ethical review board) is a group that has been formally designated to approve, monitor, and review biomedical and behavioral research involving humans with the alleged aim to protect the rights and welfare of the subjects. Wikipedia March 2008"@en, "Animal protocol review board" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "the role of a organization that is realized by members reviewing study designs for their agreement with regulations" ; obo:IAO_0000117 "Person:Helen Parkinson", "Person:Jennifer Fostel"@en ; obo:IAO_0000118 "Internal Review Board" ; obo:IAO_0000119 "OBI, CDISC"@en ; obo:IAO_0000232 "CDISC definition: institutional review board; independent ethics committee (IEC). An independent body (a review board or a committee, institutional, regional, national, or supranational) constituted of medical/scientific professionals and non-scientific members, whose responsibility it is to ensure the protection of the rights, safety and well-being of human subjects involved in a trial."@en ; a owl:Class ; rdfs:label "role of Institutional Review Board"@en ; rdfs:subClassOf obo:OBI_0000014 . obo:OBI_0000158 obo:IAO_0000111 "eSource document"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "an eSource document is a digital document consisting of a logical collection of Source data and other eSource documents that can be presented in an ordered way and capture the time of completion, change, and any signatures"@en ; obo:IAO_0000117 "person:Jennifer Fostel"@en ; obo:IAO_0000119 "article-without-pmid-or-doi:CDISCglossary" ; a owl:Class ; rdfs:label "eSource document"@en ; rdfs:subClassOf obo:IAO_0000030 . obo:OBI_0000161 obo:IAO_0000111 "crossover population role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a role realized when a participant serves as reference to itself" ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "crossover population" ; a owl:Class ; rdfs:label "crossover population role"@en ; rdfs:subClassOf obo:OBI_0000220 . obo:OBI_0000162 obo:IAO_0000111 "complete nutrient role" ; obo:IAO_0000112 "Rat chow; RPMI medium + serum; use example: CNS17 (Complete Nutrient System) Grow 3-2-4, http://www.kalyx.com/store/proddetail.cfm/ItemID/552307/CategoryID/12000/SubCatID/2755/file.htm"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A nutrient role that inheres in a material entity and is realized in the use of that material entity by an organism to provide all needed nourishment." ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "complete nutrient" ; a owl:Class ; rdfs:label "complete nutrient role"@en ; rdfs:subClassOf obo:OBI_0000204 . obo:OBI_0000163 obo:IAO_0000111 "radiolabel role"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a molecular label role which inheres in a material entity which is realized by the process of radioactivity detection"@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; obo:IAO_0000118 "radiolabel"@en ; a owl:Class ; rdfs:label "radiolabel role"@en ; rdfs:subClassOf obo:OBI_0002743 . obo:OBI_0000164 obo:IAO_0000111 "cDNA library"@en ; obo:IAO_0000112 "PMID:6110205. collection of cDNA derived from mouse splenocytes."@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 """Mixed population of cDNAs (complementaryDNA) made from mRNA from a defined source, usually a specific cell type. This term should be associated only to nucleic acid interactors not to their proteins product. For instance in 2h screening use living cells (MI:0349) as sample process. ALT DEF (PRS):: a cDNA library is a collection of host cells, typically E.Coli cells but not exclusively. modified by transfer of plasmid DNA molecule used as vector containing a fragment or totality of cDNA molecule (the insert) . cDNA library may have an array of role and applications."""@en ; obo:IAO_0000117 "PERSON: Luisa Montecchi"@en, "PERSON: Philippe Rocca-Serra"@en ; obo:IAO_0000119 "GROUP: PSI"@en ; obo:IAO_0000232 """PRS: 22022008. class moved under population, modification of definition and replacement of biomaterials in previous definition with 'material' addition of has_role restriction"""@en ; a owl:Class ; rdfs:label "clonal cDNA library"@en ; rdfs:subClassOf obo:OBI_0000731, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600064 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:OBI_0000731 ] . obo:OBI_0000167 obo:IAO_0000111 "electronic case report form"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An electronic case report form is a digital document used to record all of the protocol required information to be reported for each trial subject. An eCRF has the property that it can be audited and compliant with requirements of 21 CFR Part 11."@en ; obo:IAO_0000117 "person:Jennifer Fostel"@en ; obo:IAO_0000119 "CDISC glossary" ; a owl:Class ; rdfs:label "electronic case report form"@en ; rdfs:subClassOf obo:IAO_0000030 . obo:OBI_0000169 obo:IAO_0000111 "placebo role" ; obo:IAO_0000112 "Pill consisting of inert materials"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a negative reference substance is a reference role in which the substance playing the reference substance role is physically similar in appearance to the test substance" ; obo:IAO_0000117 "Person:Jennifer Fostel"@en ; obo:IAO_0000118 "placebo" ; obo:IAO_0000232 "CDISC definition placebo. A pharmaceutical preparation that does not contain the investigational agent. In blinded studies, it is generally prepared to be physically indistinguishable from the preparation containing the investigational product."@en ; a owl:Class ; rdfs:label "placebo role"@en ; rdfs:subClassOf obo:OBI_0000214 . obo:OBI_0000171 obo:IAO_0000111 "autotransplantation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "is the transplantation of tissue from one part of \\nthe body to another in the same individual. )"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "autotransplantation"@en ; rdfs:subClassOf obo:OBI_0000105 . obo:OBI_0000172 obo:IAO_0000111 "parameter threshold"@en ; obo:IAO_0000112 "0.01, 0.03"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A measurement datum measuring the minimal signal that must be detected to generate an electrical event, as compared to the maximal detected signal in a flow cytometer instrument. The datum has a qualitative role"@en ; obo:IAO_0000117 "person:Kevin Clancy"@en ; obo:IAO_0000119 "Submitted by the Flow Cytometry community in DigitalEntity-FlowCytometry-2007-03-30.txt" ; a owl:Class ; rdfs:label "parameter threshold"@en ; rdfs:subClassOf obo:IAO_0000109 . obo:OBI_0000174 obo:IAO_0000111 "study group role" ; obo:IAO_0000112 "The group of randomized participants that are assigned to a treatment arm of the trial" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a study population role where the bearer is a population of material entities and the role is realized in the implementation of a study design wherein the entities bearing the study population role are observed or subjected to intervention according to the study design and are biological replicates, i.e. they receive the same treatment under the protocol"@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; obo:IAO_0000118 "study group population" ; a owl:Class ; rdfs:label "study group role"@en ; rdfs:subClassOf obo:BFO_0000023 . obo:OBI_0000175 obo:IAO_0000111 "p-value"@en ; obo:IAO_0000112 """PMID:19696660 in contrast to the in-vivo data AT-III increased significantly from 113.5% at baseline to 117% after 4 days (n = 10, P-value= 0.02; Table 2).""" ; obo:IAO_0000114 obo:IAO_0000121 ; obo:IAO_0000115 "A quantitative confidence value that represents the probability of obtaining a result at least as extreme as that actually obtained, assuming that the actual value was the result of chance alone."@en ; obo:IAO_0000116 "May be outside the scope of OBI long term, is needed so is retained" ; obo:IAO_0000117 "PERSON:Chris Stoeckert"@en ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/P-value" ; a owl:Class ; rdfs:label "p-value"@en ; rdfs:subClassOf obo:OBI_0000071 . obo:OBI_0000181 obo:IAO_0000111 "population"@en ; obo:IAO_0000112 "PMID12564891. Environ Sci Technol. 2003 Jan 15;37(2):223-8. Effects of historic PCB exposures on the reproductive success of the Hudson River striped bass population."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a population is a collection of individuals from the same taxonomic class living, counted or sampled at a particular site or in a particular area"@en ; obo:IAO_0000116 """1/28/2013, BP, on the call it was raised that we may want to switch to an external ontology for all populatin terms: http://code.google.com/p/popcomm-ontology/""" ; obo:IAO_0000117 "PERSON: Philippe Rocca-Serra"@en ; obo:IAO_0000119 "adapted from Oxford English Dictionnary"@en ; obo:IAO_0000232 "rem1: collection somehow always involve a selection process"@en ; a owl:Class ; rdfs:label "population"@en ; rdfs:subClassOf obo:BFO_0000040 . obo:OBI_0000182 obo:IAO_0000111 "NMR 3D molecular structure determination assay" ; obo:IAO_0000112 "Determining the binding of epitope-specific nanobody cAb-HuL5 to wild type human lysozyme by chemical shift perturbations in NMR spectra (Erwin De Genst, J Phys Chem B 2013)." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A 3D molecular structure determination assay that uses magnetic properties of atomic nuclei to determine the 3D structure and dynamics of molecules in the input sample." ; obo:IAO_0000117 "IEDB", "PlanAndPlannedProcess Branch" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "NMR 3D molecular structure determination assay" ; rdfs:subClassOf obo:OBI_0003117 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003117 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000566 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000566 ] ) ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001155 ] ) ] . obo:OBI_0000185 obo:IAO_0000111 "imaging assay" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An assay that produces a picture of an entity." ; obo:IAO_0000117 "PlanAndPlannedProcess Branch" ; obo:IAO_0000119 "OBI branch derived" ; a owl:Class ; rdfs:label "imaging assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000101 ] . obo:OBI_0000186 obo:IAO_0000111 "protocol optimization objective"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Protocol_optimization is a protocol_testing_objective role describing a study designed to identify the best protocol. This may be carried out by comparing different protocols or by modifying the parameters used within a single protocol."@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; a owl:Class ; rdfs:label "protocol optimization objective"@en ; rdfs:subClassOf obo:OBI_0000096 . obo:OBI_0000188 obo:IAO_0000111 "role of pathology review board" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a worker role comprised of providing a confirmed and consensus diagnosis for histopathology results obtained during the investigation"@en ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "pathology review board" ; a owl:Class ; rdfs:label "role of pathology review board"@en ; rdfs:subClassOf obo:OBI_0000116 . obo:OBI_0000192 obo:IAO_0000111 "microtiter plate" ; obo:IAO_0000112 "A microtiter plate with 6, 24, 96, 384 or 1536 sample wells used in the enzyme-linked immunosorbent assay (ELISA)" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A microtiter_plate is a flat plate with multiple wells used as small test tubes." ; obo:IAO_0000117 "Melanie Courtot" ; obo:IAO_0000118 "microplate" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Microtiter_plate" ; a owl:Class ; rdfs:label "microtiter plate" ; rdfs:subClassOf obo:OBI_0000967, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000370 ] . obo:OBI_0000196 obo:IAO_0000111 "role of impartial witness" ; obo:IAO_0000112 """According to GCP , an impartial witness should be present for an illiterate subject. PharmPK Discussion, http://www.boomer.org/pkin/PK06/PK2006253.html"""@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a role which inheres in a Homo sapiens and is realized during a clinical trial - the impartial witness is independent of the trial and cannot be unfairly influenced by people involved with the trial" ; obo:IAO_0000116 "impartial witness. A person, who is independent of the trial, who cannot be unfairly influenced by people involved with the trial, who attends the informed consent process if the subject or the subject's legally acceptable representative cannot read, and who"@en ; obo:IAO_0000117 "Person: Helen Parkinson", "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "impartial witness" ; a owl:Class ; rdfs:label "role of impartial witness"@en ; rdfs:subClassOf obo:OBI_0000016 . obo:OBI_00001975 obo:IAO_0000111 "chromatin immunoprecipitation"@en ; obo:IAO_0000112 "Yang et al, Int J Clin Exp Pathol. 2015; 8(3): 2746–275 PMID:26045780. Cells were lysed and sonicated to shear DNA to lengths between 200-1000 bp. The sample was then incubated with antibodies against Acety-H3 to immunoprecipitate protein-DNA complexes using protein A agarose beads. The isolated protein-DNA complexes were treated with proteinase K digestion to remove histones. QPCR was then performed using primers specific for TGF-β1, MMP-9 and PI3K promoters at 95°C for 5 min, followed by 40 cycles at 95 °C for 20 s, 58°C for 20 s, and 72°C for 20 s. Each QPCR reaction was repeated in triplicate. QPCR was followed by a melt curve analysis to determine the reaction specificity. The relative gene expression was calculated using 2-ΔΔCt method."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An immunoprecipitation in which chromatin (i.e. packaged DNA which can include protein and RNA complexes) is cut into short regions, reversibly cross linked, and antibodies or tags are used to select for pieces of chromatin with desired characteristics."@en ; obo:IAO_0000117 "Bjoern Peters, Randi Vita, James A. Overton"@en ; obo:IAO_0000118 "ChIP"@en ; obo:IAO_0000119 "OBI"@en ; a owl:Class ; rdfs:label "chromatin immunoprecipitation"@en ; rdfs:subClassOf obo:OBI_0000690 . obo:OBI_0000198 obo:IAO_0000111 "biological replicate role" ; obo:IAO_0000112 "A member of a dose-time group; a patient in a given arm of a trial"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a reference participant role realized by equivalent treatment of participants" ; obo:IAO_0000117 "Person:Jennifer Fostel"@en ; obo:IAO_0000118 "biological replicate" ; obo:IAO_0000119 "OBI"@en ; a owl:Class ; rdfs:label "biological replicate role"@en ; rdfs:subClassOf obo:OBI_0000220 . obo:OBI_0000201 obo:IAO_0000111 "radioactivity detection" ; obo:IAO_0000112 "Placing the evaluant input material close to a scintillation counter which emits light upon being hit with alpha/beta/gamma radiation and counting the frequency of light blasts to determine the radioactivity of the input material." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures the amount of radiation in the radioactive spectrum (alpha, beta or gamma rays) emitted from an input material." ; obo:IAO_0000117 "IEDB", "PlanAndPlannedProcess Branch" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "radioactivity detection" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001741 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001741 ] ) ] ] ] ) ] . obo:OBI_0000202 obo:IAO_0000111 "investigation agent role" ; obo:IAO_0000112 "The person perform microarray experiments and submit microarray results (including raw data, processed data) with experiment description to ArrayExpress."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A role borne by an entity and that is realized in a process that is part of an investigation in which an objective is achieved. These processes include, among others: planning, overseeing, funding, reviewing."@en ; obo:IAO_0000116 "Implementing a study means carrying out or performing the study and providing reagents or other materials used in the study and other tasks without which the study would not happen.", "Philly2013: Historically, this role would have been borne only by humans or organizations. However, we now also want to enable representing investigations run by robot scientists such as ADAM (King et al, Science, 2009)" ; obo:IAO_0000117 "GROUP: Role Branch"@en ; obo:IAO_0000118 "investigator" ; obo:IAO_0000119 "OBI"@en ; obo:IAO_0000232 "Feb 10, 2009. changes after discussion at OBI Consortium Workshop Feb 2-6, 2009. accepted as core term." ; obo:OBI_0001847 "study person role" ; a owl:Class ; rdfs:comment "Philly2013: Historically, this role would have been borne only by humans or organizations. However, we now also want to enable investigations run by robot scientists such as ADAM (King et al, Science, 2009)" ; rdfs:label "investigation agent role" ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0000066 ; owl:onProperty obo:BFO_0000054 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:BFO_0000023 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000059 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0000833 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0000066 ] ] ] ] ] ) ] . obo:OBI_0000204 obo:IAO_0000111 "nutrient role" ; obo:IAO_0000112 "Luria broth; vitamin A; A nutrient is a substance used in an organism's metabolism which must be taken in from the environment. Wikipedia."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a role that inheres in a material entity and is realized in the use of that material entity by an organism when it is used in that organism's metabolism and provides nourishment."@en ; obo:IAO_0000117 "GROUP: Role branch"@en ; obo:IAO_0000118 "nutrient" ; obo:IAO_0000119 "Wikipedia, feb 29, 2008"@en ; obo:IAO_0000232 "19 Feb 2009; old def: A nutrient role is a role played by a substance used in an organism's metabolism which is taken in from the environment and provides nourishment." ; a owl:Class ; rdfs:label "nutrient role"@en ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:BFO_0000040 ] . obo:OBI_0000205 obo:IAO_0000111 "obsolete_dropout role" ; obo:IAO_0000112 "Escaped rat; human who moved to another city. Rat which escapes part way through a study; a human study participant who moved to another city before the study was completed (and stopped participating in the study)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Dropout is a study subject role borne by an entity realized by a process of leaving the study earlier than the protocol specified and where the bearer of the dropout role had been borne study subject role prior to bearing dropout role." ; obo:IAO_0000117 "Role Branch" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_dropout role" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000207 obo:IAO_0000111 "obsolete health care provider role" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a worker role of providing medical care either within or outside the study timeline" ; obo:IAO_0000117 "Person:Jennifer Fostel" ; obo:IAO_0000118 "health care provider" ; obo:IAO_0100001 obo:OMRSE_00000012 ; a owl:Class ; rdfs:label "obsolete health care provider role" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000208 obo:IAO_0000111 "methodology testing objective"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Methodology_testing_objective is an objective role carried out by a proposition defining the aim of the study is to examine the effect of using different methodologies."@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; a owl:Class ; rdfs:label "methodology testing objective"@en ; rdfs:subClassOf obo:IAO_0000005 . obo:OBI_0000210 obo:IAO_0000111 "analytical cytology data file"@en ; obo:IAO_0000112 "FCS file, ACS file, foo.fcs, foo.asc"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A digital entity intended to capture data in analytical cytology domain."@en ; obo:IAO_0000117 "person:Chris Stoeckert"@en ; obo:IAO_0000119 "group:Flow Cytometry community" ; a owl:Class ; rdfs:label "analytical cytology data file"@en ; rdfs:subClassOf obo:IAO_0000030 . obo:OBI_0000211 obo:IAO_0000111 "proxy respondent role" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Proxy respondent is a worker role of describing patient's symptoms or condition to medical personnel"@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; obo:IAO_0000118 "proxy respondent" ; a owl:Class ; rdfs:label "proxy respondent role"@en ; rdfs:subClassOf obo:OBI_0000116 . obo:OBI_0000213 obo:IAO_0000111 "fluorescence compensation matrix"@en ; obo:IAO_0000112 "((1.053096, -0.22476), (-0.24877, 1.053096))"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A fluorescence compensation matrix is a square matrix which is used as the left multiplier of the vector of fluorescence values while performing digital fluorescence compensation. Also, fluorescence compensation matrix is the inverse of the fluorescence spillover matrix."@en ; obo:IAO_0000117 "person:Chris Stoeckert"@en ; obo:IAO_0000119 "group:Flow Cytometry community" ; a owl:Class ; rdfs:label "fluorescence compensation matrix"@en ; rdfs:subClassOf obo:IAO_0000030 . obo:OBI_0000214 obo:IAO_0000111 "negative reference substance role" ; obo:IAO_0000112 "Saline solution"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a reference role in which the characteristics or responses elicited by the substance playing the reference substance role are used to establish a \"no effect\" response" ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "negative reference substance" ; a owl:Class ; rdfs:label "negative reference substance role"@en ; rdfs:subClassOf obo:OBI_0000025, [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0000070 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000215 obo:IAO_0000111 "role of legally acceptable representative" ; obo:IAO_0000112 """Parent of minor patient; Definition of legally acceptable representative An individual or juridicial or other body authorized under applicable law to consent, on behalf of a prospective subject, to the subject`s participation in the clinical trial. http://www.geneed.com/website/catalog/glossary_search.php?id=2134&search_term=legally%20acceptable%20representative&select=TRUE"""@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a role which inheres in a human or organization who are able subject to applicable law to consent, on behalf of a prospective subject, to the subject`s participation in as clinical trial." ; obo:IAO_0000116 "legally acceptable representative. An individual or juridical or other body authorized under applicable law to consent, on behalf of a prospective subject, to the subject's participation in the clinical trial. [ICH, E6 Glossary]"@en ; obo:IAO_0000117 "Person: Jennifer Fostel"@en, "Person:Helen Parkinson" ; obo:IAO_0000118 "legally acceptable representative" ; obo:IAO_0000119 "OBI, CDISC"@en ; a owl:Class ; rdfs:label "role of legally acceptable representative"@en ; rdfs:subClassOf obo:OBI_0000016 . obo:OBI_0000218 obo:IAO_0000111 "investigation results report"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An investigation report is a report on the results of an investigation."@en ; obo:IAO_0000117 "person:Chris Stoeckert"@en ; obo:IAO_0000119 "group:OBI" ; a owl:Class ; rdfs:label "investigation results report"@en ; rdfs:subClassOf obo:IAO_0000088 . obo:OBI_0000219 obo:IAO_0000111 "cellular feature identification objective"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Cellular_feature_identification_objective is a biological_feature_identification_objective role describing a study designed to examine or characterize a biological feature monitored at the cellular level, e.g. stage of cell cycle, stage of differentiation."@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; a owl:Class ; rdfs:label "cellular feature identification objective"@en ; rdfs:subClassOf obo:OBI_0000015 . obo:OBI_0000220 obo:IAO_0000111 "reference subject role" ; obo:IAO_0000112 "Saline treated rat; one of three identically-treated subjects"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a reference subject role which inheres in an organism or entity of organismal origin so that the characteristics or responses of the participant playing the reference participant role are used for comparison or reference"@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; obo:IAO_0000118 "reference participant" ; obo:IAO_0000119 "OBI"@en ; a owl:Class ; rdfs:label "reference subject role"@en ; rdfs:subClassOf obo:OBI_0000097, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0100026 obo:OBI_0100051 ) ] ] . obo:OBI_0000221 obo:IAO_0000111 "vital dye role" ; obo:IAO_0000112 "typtan blue has a vital dye" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A dye role that is realized when used to detect live cells in an experiment" ; obo:IAO_0000116 "2009-11-10. Tracker: https://sourceforge.net/tracker/?func=detail&aid=2893048&group_id=177891&atid=886178" ; obo:IAO_0000117 "Person: Helen Parkinson", "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "vital dye" ; a owl:Class ; rdfs:label "vital dye role"@en ; rdfs:subClassOf obo:OBI_0000250 . obo:OBI_0000223 obo:IAO_0000111 "obsolete_blinded medication role" ; obo:IAO_0000112 "115 patients received ipilimumab and blinded medication", "Inert pill shaped like aspirin tablet" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Is a role which inheres in a material entity which is manufactured to be similar in appearance to a test material entity in e.g. a clinical trial to prevent participants from detecting which is the active and inactive substance" ; obo:IAO_0000117 "Jennifer Fostel", "Person:Helen Parkinson" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_blinded medication role" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000224 obo:IAO_0000111 "sub-investigator role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a worker role authorized to make study-related decisions and carry out tasks related to the study; this role occurs during the study timeline"@en ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "sub-investigator" ; obo:IAO_0000232 "CDISC definition: Sub-investigator. Any member of the clinical trial team designated and supervised by the investigator at a trial site to perform critical trial-related procedures and/or to make important trial-related decisions (e.g., associates, residents, research fellows) [ICH] See associates, residents, research fellows"@en ; a owl:Class ; rdfs:label "sub-investigator role"@en ; rdfs:subClassOf obo:OBI_0000116 . obo:OBI_0000227 obo:IAO_0000111 "data encoding"@en ; obo:IAO_0000112 "storage of measurement results from an assay into a text file, such as"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a documenting process to encode an information entity into a digital document"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; obo:IAO_0000232 "We (protocol application branch) placed this term because it kept getting bounced from data transformation and DENRIE"@en ; a owl:Class ; rdfs:label "data encoding"@en ; rdfs:subClassOf obo:IAO_0000572 . obo:OBI_0000231 obo:IAO_0000111 "enzymatic cleavage"@en ; obo:IAO_0000112 "Polymorphism R62W results in resistance of CD23 to enzymatic cleavage in cultured cells. Genes Immun. 2007 Apr;8(3):215-23. Epub 2007 Feb 15. PMID: 17301828"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a material processing that digests the fraction of input material that is susceptible to that enzyme"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "enzymatic cleavage"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000427 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100051 ] . obo:OBI_0000232 obo:IAO_0000111 "hardware optimization objective"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Hardware_optimization is a hardware_testing_objective describing a study designed to identify the best hardware."@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; a owl:Class ; rdfs:label "hardware optimization objective"@en ; rdfs:subClassOf obo:OBI_0000134 . obo:OBI_0000233 obo:IAO_0000111 "obsolete_defined_material" ; obo:IAO_0000114 obo:IAO_0000121 ; obo:IAO_0000115 "Place holder class, Utility class to gather the defined classes" ; obo:IAO_0000117 "Susanna Sansone" ; obo:IAO_0000119 "OBI Biomaterial derived" ; obo:IAO_0000231 obo:IAO_0000226 ; a owl:Class ; rdfs:label "obsolete_defined_material" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000234 obo:IAO_0000111 "trial statistician role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a worker role that analyzes data obtained during a trial or study; this role occurs after the trial or study is completed or terminated."@en ; obo:IAO_0000117 "Person:Jennifer Fostel"@en ; obo:IAO_0000118 "trial statistician" ; obo:IAO_0000232 "CDISC definition: trial statistician. A statistician who has a combination of education/training and experience sufficient to implement the principles in the ICH E9 guidance and who is responsible for the statistical aspects of the trial. [ICH E9]"@en ; a owl:Class ; rdfs:label "trial statistician role"@en ; rdfs:subClassOf obo:OBI_0000116, [ a owl:Restriction ; owl:allValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000059 ; owl:someValuesFrom obo:OBI_0500001 ] ] ] ) ] ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000235 obo:IAO_0000111 "standard error"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A quantitative confidence value which is the standard deviations of the sample in a frequency distribution, obtained by dividing the standard deviation by the total number of cases in the frequency distribution."@en ; obo:IAO_0000117 "person:Chris Stoeckert"@en ; obo:IAO_0000119 "group:OBI" ; obo:IAO_0000232 "see P-Value"@en ; a owl:Class ; rdfs:label "standard error"@en ; rdfs:subClassOf obo:OBI_0000071 . obo:OBI_0000237 obo:IAO_0000111 "antigen role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A role of a material entity that is being recognized in whole or in part by receptors of the immune system such as antibodies or T cell receptors."@en ; obo:IAO_0000116 "An antigen is a substance that prompts the generation of antibodies and can cause an immune response. Wikipedia http://en.wikipedia.org/wiki/Antigen. In the strict sense, immunogens are those substances that elicit a response from the immune system, whereas antigens are defined as substances that bind to specific antibodies. Not all antigens produce an immunogenic response, but all immunogens are antigens" ; obo:IAO_0000117 "Role Branch"@en ; obo:IAO_0000119 "OBI" ; obo:IAO_0000232 "9Mar09 waiting for discussion with immunology terms" ; a owl:Class ; rdfs:label "antigen role"@en ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:allValuesFrom obo:GO_0006955 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000242 obo:IAO_0000111 "software testing objective"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Software_testing_objective is a hardware_optimization role describing a study designed to examine the effects of using different software or software parameters, e.g. data processing software."@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; a owl:Class ; rdfs:label "software testing objective"@en ; rdfs:subClassOf obo:OBI_0000208 . obo:OBI_0000243 obo:IAO_0000111 "sponsor role"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a responsible party role involved with any of the following activities: initiating, managing and funding a study"@en ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "sponsor" ; obo:IAO_0000232 "CDISC definition: sponsor. 1. An individual, company, institution, or organization that takes responsibility for the initiation, management, and/or financing of a clinical trial. 2. A corporation or agency whose employees conduct the investigation is considered a sponsor; employees are considered investigators"@en ; a owl:Class ; rdfs:label "sponsor role"@en ; rdfs:subClassOf obo:OBI_0000102 . obo:OBI_0000245 obo:IAO_0000111 "organization"@en ; obo:IAO_0000112 "PMID: 16353909.AAPS J. 2005 Sep 22;7(2):E274-80. Review. The joint food and agriculture organization of the United Nations/World Health Organization Expert Committee on Food Additives and its role in the evaluation of the safety of veterinary drug residues in foods."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members."@en ; obo:IAO_0000116 """BP: The definition summarizes long email discussions on the OBI developer, roles, biomaterial and denrie branches. It leaves open if an organization is a material entity or a dependent continuant, as no consensus was reached on that. The current placement as material is therefore temporary, in order to move forward with development. Here is the entire email summary, on which the definition is based: 1) there are organization_member_roles (president, treasurer, branch editor), with individual persons as bearers 2) there are organization_roles (employer, owner, vendor, patent holder) 3) an organization has a charter / rules / bylaws, which specify what roles there are, how they should be realized, and how to modify the charter/rules/bylaws themselves. It is debatable what the organization itself is (some kind of dependent continuant or an aggregate of people). This also determines who/what the bearer of organization_roles' are. My personal favorite is still to define organization as a kind of 'legal entity', but thinking it through leads to all kinds of questions that are clearly outside the scope of OBI. Interestingly enough, it does not seem to matter much where we place organization itself, as long as we can subclass it (University, Corporation, Government Agency, Hospital), instantiate it (Affymetrix, NCBI, NIH, ISO, W3C, University of Oklahoma), and have it play roles. This leads to my proposal: We define organization through the statements 1 - 3 above, but without an 'is a' statement for now. We can leave it in its current place in the is_a hierarchy (material entity) or move it up to 'continuant'. We leave further clarifications to BFO, and close this issue for now."""@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg", "PERSON: Bjoern Peters", "PERSON: Philippe Rocca-Serra", "PERSON: Susanna Sansone" ; obo:IAO_0000119 "GROUP: OBI" ; a owl:Class ; rdfs:label "organization"@en ; rdfs:subClassOf obo:BFO_0000040 . obo:OBI_0000248 obo:IAO_0000111 "feed role" ; obo:IAO_0000112 "Purina rat chow; cited use: Control; F = feed (rat chow); W = water; F. g. = feed-ginger concentrate. www.academicjournals.org/AJB/PDF/pdf2007/19Sep/Egwurugwu%20et%20al.pdf - Feb 29, 2008"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a role that inheres in a material entity and is realized in the use of that material entity by lab animal to provide all needed nourishment." ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "feed" ; obo:IAO_0000119 "OBI"@en ; a owl:Class ; rdfs:label "feed role"@en ; rdfs:subClassOf obo:OBI_0000162 . obo:OBI_0000249 obo:IAO_0000111 "technical replicate role" ; obo:IAO_0000112 "Aliquots of a tissue subjected to parallel assays"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "technical replicate role is realized when two portions from one evaluant are used in replicate runs of an assay" ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "technical replicate" ; a owl:Class ; rdfs:label "technical replicate role"@en ; rdfs:subClassOf obo:OBI_0000220 . obo:OBI_0000250 obo:IAO_0000111 "dye role"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A molecular label role which inheres in a material entity and which is realized in the process of detecting a molecular dye that imparts color to some material of interest." ; obo:IAO_0000117 "Jennifer Fostel"@en ; obo:IAO_0000118 "dye" ; obo:IAO_0000119 "A substance used to color materials www.answers.com/topic/dye 19feb09" ; a owl:Class ; rdfs:label "dye role"@en ; rdfs:subClassOf obo:OBI_0002743 . obo:OBI_0000251 obo:IAO_0000111 "cluster"@en ; obo:IAO_0000112 "Cluster of the lymphocytes population."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A data set which is a subset of data that are a similar to each other in some way."@en ; obo:IAO_0000117 "person:Allyson"@en, "person:Chris Stoeckert"@en ; obo:IAO_0000119 "group:OBI" ; a owl:Class ; rdfs:label "cluster"@en ; rdfs:subClassOf obo:IAO_0000100 . obo:OBI_0000252 obo:IAO_0000111 "cohort role" ; obo:IAO_0000112 "In statistics and demography, a cohort is a group of subjects - most often humans from a given population - defined by experiencing an event (typically birth) in a particular time span. Wikipedia \"cohort\", Feb 29 2008"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a cohort role is a biological replicate role played by a group of study participants who share a common characteristic of interest to the study."@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; obo:IAO_0000119 "WEB:http://www.sceoc.com/glossaryofterms/ # a group of individuals having a statistical factor (as age or class membership) in common in a demographic study, such as a cohort of students.", "WEB:http://www.thebody.org/content/treat/art2612.html # a group of individuals in a study who share a demographic, clinical, or other statistical characteristic (eg, age, study site).", "WEB:http://www.uhhospitals.org/tabid/591/Default.aspx # A cohort is a group of people with a common characteristic that is studied over a period of time as part of a scientific or medical investigation." ; a owl:Class ; rdfs:label "cohort role"@en ; rdfs:subClassOf obo:OBI_0000198 . obo:OBI_0000253 obo:IAO_0000111 "artificially induced nucleic acid hybridization"@en ; obo:IAO_0000112 "www.ornl.gov/sci/techresources/Human_Genome/publicat/97pr/09gloss.html, http://www.accessexcellence.org/RC/VL/GG/nucleic.html, http://omrf.ouhsc.edu/~frank/HYBNOTES.html. http://en.wikipedia.org/wiki/Nucleic_acid_hybridization,http://www.pnas.org/cgi/reprint/46/8/1044.pdf"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Is a material transformation in which strands of nucleic acids that are (somewhat) complementary form a double-stranded molecule. Has input at least two single stranded molecules of nucleic acid molecules."@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "artificially induced nucleic acid hybridization"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0000257 obo:IAO_0000111 "DNA extraction"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A DNA extraction is a nucleic acid extraction where the desired output material is DNA."@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "DNA extraction"@en ; rdfs:subClassOf obo:OBI_0666667, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001051 ] . obo:OBI_0000260 obo:IAO_0000111 "plan"@en ; obo:IAO_0000112 "The plan of researcher X to perform an experiment according to a protocol." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A plan is a realizable entity that is the inheres in a bearer who is committed to realizing it as a planned process."@en ; obo:IAO_0000116 "This class is included to make clear how the plan specification, the plan, and the planned process relate. OBI will however only subclass and work under the 'plan specification', and 'planned process' class, as we want to avoid to get deep into discussions of 'intend' etc." ; obo:IAO_0000117 "AR, BP, JM, MC, PRS"@en ; obo:IAO_0000119 "branch derived"@en ; a owl:Class ; rdfs:label "plan"@en ; rdfs:subClassOf obo:BFO_0000017 . obo:OBI_0000264 obo:IAO_0000111 "obsolete_sample population" ; obo:IAO_0000112 "Patterns of benzylpiperazine/trifluoromethylphenylpiperazine party pill use and adverse effects in a population sample in New Zealand. Drug Alcohol Rev. 2008 Mar 31:1-7. PMID: 18608458" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A sample population is an object aggregate that is selected from the population, e.g. the fish in the net that were sampled from the lake, the people that responded to the call for volunteers." ; obo:IAO_0000117 "PERSON: Jennifer Fostel", "PERSON: Philippe Rocca-Serra" ; obo:IAO_0000118 "recruited population" ; obo:IAO_0000119 "GROUP: OBI Biomaterial Branch" ; obo:IAO_0000231 obo:IAO_0000227 ; a owl:Class ; rdfs:label "obsolete_sample population" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000268 obo:IAO_0000111 "organism feature identification objective"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Organism_feature_identification_objective is a biological_feature_identification_objective role describing a study designed to examine or characterize a biological feature monitored at the level of the organism, e.g. height, weight, stage of development, stage of life cycle."@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; a owl:Class ; rdfs:label "organism feature identification objective"@en ; rdfs:subClassOf obo:OBI_0000015 . obo:OBI_0000269 obo:IAO_0000111 "number of lost events computer"@en ; obo:IAO_0000112 "0, 125, 787 events lost due to computer busy."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A measurement datum recording the number of measurement events lost due to overloading of the analysis chip in a flow cytometer instrument. The datum has a qualitative role"@en ; obo:IAO_0000117 "person:Kevin Clancy"@en ; obo:IAO_0000119 "Submitted by the Flow Cytometry community in DigitalEntity-FlowCytometry-2007-03-30.txt" ; a owl:Class ; rdfs:label "number of lost events computer"@en ; rdfs:subClassOf obo:IAO_0000109 . obo:OBI_0000272 obo:IAO_0000111 "protocol"@en ; obo:IAO_0000112 "PCR protocol, has objective specification, amplify DNA fragment of interest, and has action specification describes the amounts of experimental reagents used (e..g. buffers, dNTPS, enzyme), and the temperature and cycle time settings for running the PCR."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A plan specification which has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process."@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived + wikipedia (http://en.wikipedia.org/wiki/Protocol_%28natural_sciences%29)"@en ; obo:OBI_0001847 "study protocol" ; a owl:Class ; rdfs:label "protocol"@en ; rdfs:subClassOf obo:IAO_0000104 . obo:OBI_0000273 obo:IAO_0000111 "role of regulator of consumables and medical devices" ; obo:IAO_0000112 "FDA, EMEA; http://www.fda.gov/; The International Conference of Drug Regulatory Authorities (ICDRAs) provide drug regulatory authorities of WHO Member States with a forum to meet and discuss ways to strengthen collaboration.http://www.who.int/medicines/areas/quality_safety/regulation_legislation/icdra/en/index.html"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a regulator involved with making and enforcing legislation and governmental orders relevant to the development, testing, manufacture and use of food, drugs and medical devices"@en ; obo:IAO_0000117 "Person: Jennifer Fostel"@en ; obo:IAO_0000118 "drug regulatoy authority" ; obo:IAO_0000119 "OBI, CDISC"@en ; a owl:Class ; rdfs:label "role of regulator of consumables and medical devices"@en ; rdfs:subClassOf obo:OBI_0000014 . obo:OBI_0000274 obo:IAO_0000111 "adding a material entity into a target" ; obo:IAO_0000112 "Injecting a drug into a mouse. Adding IL-2 to a cell culture. Adding NaCl into water." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "is a process with the objective to place a material entity bearing the 'material to be added role' into a material bearing the 'target of material addition role'."@en ; obo:IAO_0000116 "Class was renamed from 'administering substance', as this is commonly used only for additions into organisms." ; obo:IAO_0000117 "BP" ; obo:IAO_0000119 "branch derived" ; a owl:Class ; rdfs:label "adding a material entity into a target"@en ; rdfs:subClassOf obo:OBI_0000652, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_0000319 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_0000444 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000319 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000444 ] ) ] ] ) ] ] ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000434 ] . obo:OBI_0000275 obo:IAO_0000111 "analyte role" ; obo:IAO_0000112 "Glucose in blood (measured in an assay to determine the concentration of glucose)." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A measurand role borne by a molecular entity or an atom and realized in an analyte assay which achieves the objective to measure the magnitude/concentration/amount of the analyte in the entity bearing evaluant role."@en ; obo:IAO_0000116 "interestingly, an analyte is still an analyte even if it is not detected. for this reason it does not bear a specified input role", "pH (technically the inverse log of [H+]) may be considered a quality; this remains to be tested.", "qualities such as weight, color are not assayed but measured, so they do not fall into this category." ; obo:IAO_0000117 "GROUP: Role Branch" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000232 "Feb 10, 2009. changes after discussion at OBI Consortium Workshop Feb 2-6, 2009. accepted as core term." ; a owl:Class ; rdfs:label "analyte role"@en ; rdfs:subClassOf obo:OBI_0002444, [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:CHEBI_23367 obo:CHEBI_33250 ) ] ] . obo:OBI_0000278 obo:IAO_0000111 "disease stage" ; obo:IAO_0000112 "Stage II breast cancer, The timepoint of recovery from a disease"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a part of an occurrence of a disease process which is associated with position in the normal progression of the disease"@en ; obo:IAO_0000117 "PERSON: Bjoern peters" ; a owl:Class ; rdfs:label "disease stage"@en ; rdfs:subClassOf obo:GO_0008150, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OGMS_0000063 ] . obo:OBI_0000281 obo:IAO_0000111 "intraperitoneal injection" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is the injection of a material entity (bearing the administered substance role) into the peritoneum (bearing the target role) of an organism using a syringe" ; obo:IAO_0000117 "BP" ; a owl:Class ; rdfs:label "intraperitoneal injection" ; rdfs:subClassOf obo:OBI_0000426, obo:OBI_0000429 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000429 [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000422 ] ) ] ] ) ] . obo:OBI_0000286 obo:IAO_0000111 "precipitate"@en ; obo:IAO_0000112 "Physicochemical properties and antibacterial activity of the precipitate of vancomycin and ceftazidime: implications in the management of endophthalmitis. Retina. 2008 Feb;28(2):320-5. PMID: 18301038"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a precipitate is a material entity which is output of a precipitation process"@en ; obo:IAO_0000117 "PERSON: Philippe Rocca-Serra" ; obo:IAO_0000118 "precipited material"@en ; obo:IAO_0000119 "GROUP: OBI Biomaterial Branch" ; a owl:Class ; rdfs:label "precipitate"@en ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600034 ] . obo:OBI_0000288 obo:IAO_0000111 "protein-protein interaction detection assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay that determines interactions between proteins, such as protein-protein binding." ; a owl:Class ; rdfs:label "protein-protein interaction detection assay" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0000291 obo:IAO_0000111 "transcription factor binding site assay" ; obo:IAO_0000112 "Transcription factor binding site identification in yeast: a comparison of high-density oligonucleotide and PCR-based microarray platforms." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay tthat determines DNA regions specifically recognized by proteins that function as transcription factors" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "TF binding" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://sourceforge.net/p/obi/obi-terms/767/" ; a owl:Class ; rdfs:label "transcription factor binding site assay" ; rdfs:subClassOf obo:OBI_0001146, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000030 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:SO_0000235 ] ] . obo:OBI_0000292 obo:IAO_0000111 "has_feature_value" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "has_feature_value datatype property is used to describe the feature values which the feature class can contain, for example has_base can have feature values of nonNegativeInteger values."@en ; obo:IAO_0000117 "James Malone"@en ; a owl:DatatypeProperty ; rdfs:domain obo:OBI_0200140 ; rdfs:label "has_feature_value"@en . obo:OBI_0000293 obo:IAO_0000111 "has_specified_input", "has_specified_input"@en ; obo:IAO_0000112 "see is_input_of example_of_usage"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "The inverse property of is_specified_input_of"@en ; obo:IAO_0000116 "8/17/09: specified inputs of one process are not necessarily specified inputs of a larger process that it is part of. This is in contrast to how 'has participant' works." ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Bjoern Peters", "PERSON: Larry Hunter", "PERSON: Melanie Coutot" ; obo:IAO_0000412 ; a owl:ObjectProperty ; rdfs:domain obo:OBI_0000011 ; rdfs:label "has_specified_input"@en ; rdfs:subPropertyOf obo:RO_0000057 ; owl:equivalentProperty [ owl:inverseOf obo:OBI_0000295 ] ; owl:inverseOf obo:OBI_0000295 . obo:OBI_0000294 obo:IAO_0000111 "is_concretization_of" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Is a relationship between a generically dependent continuant and a specifically dependent continuant. A generically dependent continuant may inhere in more than one entity. It does so by virtue of the fact that there is, for each entity that it inheres, a specifically dependent *concretization* of the generically dependent continuant that is specifically dependent. For instance, consider a story, which is an information artifact that inheres in some number of books. Each book bears some quality that carries the story. The relation between this quality and the generically dependent continuant is that the former is the concretization of the latter." ; obo:IAO_0000116 "replaced by: http://purl.obolibrary.org/obo/BFO_0000058" ; obo:IAO_0000117 "PERSON: Alan Ruttenburg", "PERSON: Barry Smith" ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:ObjectProperty ; rdfs:label "obsolete_is_concretization_of"@en ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:OBI_0000295 obo:IAO_0000111 "is_specified_input_of" ; obo:IAO_0000112 "some Autologous EBV(Epstein-Barr virus)-transformed B-LCL (B lymphocyte cell line) is_input_for instance of Chromum Release Assay described at https://wiki.cbil.upenn.edu/obiwiki/index.php/Chromium_Release_assay"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of."@en ; obo:IAO_0000117 "Alan Ruttenberg"@en, "PERSON:Bjoern Peters" ; a owl:ObjectProperty ; rdfs:label "is_specified_input_of"@en ; rdfs:range obo:OBI_0000011 ; rdfs:subPropertyOf obo:RO_0000056 . obo:OBI_0000296 obo:IAO_0000111 "obsolete_enrollment" ; obo:IAO_0000112 "Enrollment of patients in a study. Short-term outcome of neuropsychiatric events in systemic lupus erythematosus upon enrollment into an international inception cohort study. Arthritis Rheum. 2008 May 15;59(5):721-9. PMID: 18438902" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "enrollment is a process of identifying a set of objects for further use in an investigation based on a set of criteria or rules" ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:IAO_0000231 obo:IAO_0000227 ; a owl:Class ; rdfs:label "obsolete_enrollment" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000297 obo:IAO_0000111 "is_concretized_as" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Is a relationship between a specifically dependent continuant and a generically dependent continuant. A generically dependent continuant may inhere in more than one entity. It does so by virtue of the fact that there is, for each entity that it inheres, a specifically dependent *concretization* of the generically dependent continuant that is specifically dependent. For instance, consider a story, which is an information artifact that inheres in some number of books. Each book bears some quality that carries the story. The relation between this quality and the generically dependent continuant is that the former is the concretization of the latter." ; obo:IAO_0000116 "replaced by: http://purl.obolibrary.org/obo/BFO_0000059" ; obo:IAO_0000117 "PERSON: Alan Ruttenberg", "PERSON: Barry Smith" ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:ObjectProperty ; rdfs:label "obsolete_is_concretized_as"@en ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:OBI_0000298 obo:IAO_0000111 "has_quality" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 """A relation between an entity and a quality. For types: E has_quality Q iff: for any eEt, exists qQt such that q inheres_in e at t. For instances: e has_quality q at t iff q inheres_in e at t and q instance-of Quality [GOC:cjm]""" ; obo:IAO_0000116 "replaced by: http://purl.obolibrary.org/obo/BFO_0000086" ; obo:IAO_0000117 "GROUP:OBI:", "PERSON: Chris Mungall" ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:ObjectProperty ; rdfs:label "obsolete_has_quality"@en ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:OBI_0000299 obo:IAO_0000111 "has_specified_output", "has_specified_output"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "The inverse property of is_specified_output_of"@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Bjoern Peters", "PERSON: Larry Hunter", "PERSON: Melanie Courtot" ; obo:IAO_0000412 ; a owl:ObjectProperty ; rdfs:domain obo:OBI_0000011 ; rdfs:label "has_specified_output"@en ; rdfs:subPropertyOf obo:RO_0000057 ; owl:equivalentProperty [ owl:inverseOf obo:OBI_0000312 ] ; owl:inverseOf obo:OBI_0000312 . obo:OBI_0000300 obo:IAO_0000111 "is_realized_by" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "Relation between a realizable and a process. Reciprocal relation of realizes [GOC:cjm]" ; obo:IAO_0000116 "replaced by http://purl.obolibrary.org/obo/BFO_0000054: 'is realized by'" ; obo:IAO_0000117 "GROUP:OBI:", "PERSON: Chris Mungall" ; obo:IAO_0000118 "executed_during", "has_realization", "is_realized_as" ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:ObjectProperty ; rdfs:label "obsolete_is_realized_by"@en ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:OBI_0000301 obo:IAO_0000111 "obsoleted_has_specified_output_information" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A relation between a participant in a process, that produces a data set . The process is the realization of a concretization of a realizable information entity (objective specification or plan specification). In general, not all data present at the end of the process are specified_data."@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Frank Gibson" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:ObjectProperty ; rdfs:label "obsoleted_has_specified_output_information"@en ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:OBI_0000304 obo:IAO_0000111 "is_manufactured_by"@en ; obo:IAO_0000112 "http://www.affymetrix.com/products/arrays/specific/hgu133.affx is_manufactered_by http://www.affymetrix.com/ (if we decide to use these URIs for the actual entities)"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "c is_manufactured_by o means that there was a process p in which c was built in which a person, or set of people or machines did the work(bore the \"Manufacturer Role\", and those people/and or machines were members or of directed by the organization to do this."@en ; obo:IAO_0000117 "Alan Ruttenberg"@en, "Liju Fan"@en ; obo:IAO_0000118 "has_make"@en, "has_manufacturer"@en ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "is_manufactured_by"@en ; rdfs:range obo:OBI_0000835 . obo:OBI_0000306 obo:IAO_0000111 "has_function" ; obo:IAO_0000112 "heart has_function to-pump-blood" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "Relation between an independent continuant and a function." ; obo:IAO_0000116 "replaced by: http://purl.obolibrary.org/obo/BFO_0000085" ; obo:IAO_0000117 "GROUP:OBI:", "PERSON: Chris Mungall" ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:ObjectProperty ; rdfs:label "obsolete_has_function"@en ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:OBI_0000307 obo:IAO_0000111 "obsoleted_is_reagent_in" ; obo:IAO_0000112 "some Triton X-100 (Sigma-Aldrich) is_reagent_in instance of Chromium Release Assay described at https://wiki.cbil.upenn.edu/obiwiki/index.php/Chromium_Release_assay"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Relationship between a substance and a protocol application in which it participates, where the substance has a ReagentRole"@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:ObjectProperty ; rdfs:label "obsoleted_is_reagent_in"@en ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:OBI_0000308 obo:IAO_0000111 "realizes" ; obo:IAO_0000112 """example of usage: The process of 'histidine catabolism' (GO:0006548) realizes the function 'histidine ammonia lyase activity' (GO:0004397) (note: here 'activity' denotes a function and not a process). We leave open the possibility of defining in future the sub-relations directly_realizes (as bewteen a function and it's functioning) and indirectly_realizes.""" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 """Relation between a process and a function, where the unfolding of the process requires the execution of the function. Class level: P realizes F iff: given any p that instantiates P, there exists some f, t such that f instantiates F at t and p *realizes* f. Here, *realizes* is the primitive instance level relation [GOC:cjm]""" ; obo:IAO_0000116 "replaced by http://purl.obolibrary.org/obo/BFO_0000055: 'realizes'" ; obo:IAO_0000117 "GROUP:OBI:", "PERSON: Chris Mungal" ; obo:IAO_0000118 "executes", "has_function_part", "involves_execution_of", "is_realization_of" ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:ObjectProperty ; rdfs:label "obsolete_realizes"@en ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:OBI_0000309 obo:IAO_0000111 "obsoleted_utilizes_reagent" ; obo:IAO_0000112 "see example_of_usage for is_reagent_in"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Relationship between a protocol application and a substance that has role reagent that participates in the protocol application"@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:ObjectProperty ; rdfs:label "obsoleted_utilizes_reagent"@en ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:OBI_0000310 obo:IAO_0000111 "adverse event trigger"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "revisit?"@en ; obo:IAO_0000117 "PERSON:Alan Ruttenberg"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "adverse event trigger"@en ; rdfs:subClassOf obo:IAO_0000001 . obo:OBI_0000311 obo:IAO_0000111 "obsoleted_is_device_for" ; obo:IAO_0000112 "some LKB 1272 Clinigamma counter is_device_for instance of Chromium Release Assay described at https://wiki.cbil.upenn.edu/obiwiki/index.php/Chromium_Release_assay"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Relationship between a device and a protocol application in which it participates"@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:ObjectProperty ; rdfs:label "obsoleted_is_device_for"@en ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:OBI_0000312 obo:IAO_0000111 "is_specified_output_of", "is_specified_output_of"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of."@en ; obo:IAO_0000117 "Alan Ruttenberg"@en, "PERSON:Bjoern Peters" ; obo:IAO_0000412 ; a owl:ObjectProperty ; rdfs:label "is_specified_output_of"@en ; rdfs:range obo:OBI_0000011 ; rdfs:subPropertyOf obo:RO_0000056 . obo:OBI_0000313 obo:IAO_0000111 "obsoleted_utilizes_device" ; obo:IAO_0000112 "see example_of_usage for is_device_for"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Relationship between protocol application and an intrument in which it participates"@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:ObjectProperty ; rdfs:label "obsoleted_utilizes_device"@en ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:OBI_0000314 obo:IAO_0000111 "is_proxy_for" ; obo:IAO_0000112 """position on a gel is_proxy_for mass and charge of molecule in an western blot. Florescent intensity is_proxy_for amount of protein labeled with GFP. Examples: A260/A280 (of a DNA sample) is_proxy_for DNA-purity. NMR Sample scan is a proxy for sample quality. Within the assay mentioned here: https://wiki.cbil.upenn.edu/obiwiki/index.php/Chromium_Release_assay level of radioactivity is_proxy_for level of toxicity"""@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A relation between continuant instances c1 and c2 where within an experiment/ protocol application, measurement of c1 is used to determine what a measurement of c2 would be."@en ; obo:IAO_0000116 """A relation between continuant instances c1 and c2 where within a protocol application, measurement of c1 is related to a what would be the measurement of c2. (another definition)"""@en ; obo:IAO_0000117 "Alan Ruttenberg"@en ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000002 ; rdfs:label "is_proxy_for"@en ; rdfs:range obo:BFO_0000002 . obo:OBI_0000315 obo:IAO_0000111 "has specified input information" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A relation between a process and a participant in that process, that consumes a data set . The process is the realization of a concretization of a directive information entity (objective specification or plan specification). In general, not all data present at the beginning of the process are specified_data."@en ; obo:IAO_0000117 "PERSON: Frank Gibson", "PERSON:Alan Ruttenberg"@en ; obo:IAO_0000118 "consumes data" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:ObjectProperty ; rdfs:label "obsoleted_has_specified_input_information"@en ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:OBI_0000316 obo:IAO_0000111 "has_role" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A relation between a continuant C and a role R. The reciprocal relation of role_of." ; obo:IAO_0000116 "replaced by: http://purl.obolibrary.org/obo/BFO_0000087" ; obo:IAO_0000117 "GROUP:OBI:", "PERSON:Chris Mungal" ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:ObjectProperty ; rdfs:label "obsolete_has_role"@en ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:OBI_0000317 obo:IAO_0000111 "Transformation-ML"@en ; obo:IAO_0000112 "Transformation-ML file describing parameter transformations used in a GvHD experiment."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Transformation-ML is a format standard of a digital entity that is conformant with the Transformation-ML standard.(http://wiki.ficcs.org/ficcs/Transformation-ML?action=AttachFile&do=get&target=Transformation-ML_v1.0.26.pdf)"@en ; obo:IAO_0000117 "person:Jennifer Fostel"@en ; obo:IAO_0000119 "web-page:http://wiki.ficcs.org/ficcs/Transformation-ML?action=AttachFile&do=get&target=Transformation-ML_v1.0.26.pdf" ; a obo:IAO_0000098, owl:NamedIndividual ; rdfs:label "Transformation-ML"@en . obo:OBI_0000318 obo:IAO_0000111 "eluate"@en ; obo:IAO_0000112 "Raman spectroscopic detection of haemoproteins in the eluate from high-performance liquid chromatography. J Chromatogr. 1983 Jan 7;254:285-8. PMID: 6298263"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a eluate is a material entity which results from an elution, e.g. from a chromatography column. it has as part a material entity with role mobile phase"@en ; obo:IAO_0000116 """need to add restriction to indicate: has_part some (material entity has_role mobile phase) need to add mobile phase as role"""@en ; obo:IAO_0000117 "PERSON: Philippe Rocca-Serra" ; obo:IAO_0000118 "eluted material"@en ; obo:IAO_0000119 "OBI Bionaterial" ; a owl:Class ; rdfs:label "eluate"@en ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_23367 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0302732 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0302905 ] . obo:OBI_0000319 obo:IAO_0000111 "material to be added role" ; obo:IAO_0000112 "drug added to a buffer contained in a tube; substance injected into an animal;" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A role of a material entity that is realized in an \"adding a material entity into a target\" process where the bearer of the role is added into another material entity (the target)."@en ; obo:IAO_0000117 "Role Branch" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000232 "9 March 09 from discussion with PA branch" ; a owl:Class ; rdfs:label "material to be added role"@en ; rdfs:subClassOf obo:BFO_0000023 . obo:OBI_0000321 obo:IAO_0000111 "ACS"@en ; obo:IAO_0000112 "d06.acs, ACS1.0 data file of well D06 of plate 2 of part 1 of a GvHD experiment."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "ACS is a format standard of a digital entity that is conformant with the Analytical Cytometry Standard. (http://www.isac-net.org/content/view/607/150/)"@en ; obo:IAO_0000117 "person:Jennifer Fostel"@en ; obo:IAO_0000119 "web-page:http://www.isac-net.org/content/view/607/150/" ; a obo:IAO_0000098, owl:NamedIndividual ; rdfs:label "ACS"@en . obo:OBI_0000322 obo:IAO_0000111 "XML"@en ; obo:IAO_0000112 "RDF/XML file, OWL file, Compensation-ML file, WSDL document, SVG document"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "XML is a format standard of a digital entity that is conformant with the W3C Extensible Markup Language Recommendation.(http://www.w3.org/XML/)"@en ; obo:IAO_0000117 "person:Jennifer Fostel"@en ; obo:IAO_0000119 "web-page:http://www.w3.org/XML/" ; a obo:IAO_0000098, owl:NamedIndividual ; rdfs:label "XML"@en . obo:OBI_0000323 obo:IAO_0000111 "obsolete_peritoneum" ; obo:IAO_0000114 obo:IAO_0000002 ; obo:IAO_0000115 "is the serous membrane that forms the lining of the abdominal cavity" ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:Class ; rdfs:label "obsolete_peritoneum" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000324 obo:IAO_0000111 "RDF"@en ; obo:IAO_0000112 "A FOAF file, a SKOS file, an OWL file."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "RDF is a format standard of a digital entity that is conformant with the W3C Resource Description Framework RDF/XML Syntax specification.(http://www.w3.org/RDF/)"@en ; obo:IAO_0000117 "person:Jennifer Fostel"@en ; obo:IAO_0000119 "web-page:http://www.w3.org/RDF/" ; a obo:IAO_0000098, owl:NamedIndividual ; rdfs:label "RDF"@en . obo:OBI_0000325 obo:IAO_0000111 "zip"@en ; obo:IAO_0000112 "MagicDraw MDZIP archive, Java JAR file."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "zip is a format standard of a digital entity that is conformant with the PKWARE .ZIP file format specification (http://www.pkware.com/index.php?option=com_content&task=view&id=59&Itemid=103/)"@en ; obo:IAO_0000117 "person:Jennifer Fostel"@en ; obo:IAO_0000119 "web-page:http://www.pkware.com/index.php?option=com_content&task=view&id=59&Itemid=103/" ; a obo:IAO_0000098, owl:NamedIndividual ; rdfs:label "zip"@en . obo:OBI_0000326 obo:IAO_0000111 "tar"@en ; obo:IAO_0000112 "Example.tar file."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "tar is a format standard of a digital entity that is conformant with the tape archive file format as standardized by POSIX.1-1998, POSIX.1-2001, or any other tar format compliant with the GNU tar specification. (http://www.gnu.org/software/tar/manual/)"@en ; obo:IAO_0000117 "person:Jennifer Fostel"@en ; obo:IAO_0000119 "web-page:http://www.gnu.org/software/tar/manual/" ; a obo:IAO_0000098, owl:NamedIndividual ; rdfs:label "tar"@en . obo:OBI_0000327 obo:IAO_0000111 "FCS"@en ; obo:IAO_0000112 "d01.fcs, FCS3 data file of well D06 of plate 2 of part 1 of a GvHD experiment."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "FCS is a format standard of a digital entity that is conformant with the Flow Cytometry Data File Standard.(http://www.fcspress.com/)"@en ; obo:IAO_0000117 "person:Jennifer Fostel"@en ; obo:IAO_0000119 "web-page:http://www.fcspress.com/" ; a obo:IAO_0000098, owl:NamedIndividual ; rdfs:label "FCS"@en . obo:OBI_0000329 obo:IAO_0000111 "Compensation-ML"@en ; obo:IAO_0000112 "compfoo.xml, Compensation-ML file describing compensation used in a GvHD experiment"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Compensation-ML is a format standard of a digital entity that is conformant with the Compensation-ML standard. (http://wiki.ficcs.org/ficcs/Compensation-ML?action=AttachFile&do=get&target=Compensation-ML_v1.0.24.pdf)"@en ; obo:IAO_0000117 "person:Jennifer Fostel"@en ; obo:IAO_0000119 "web-page:http://wiki.ficcs.org/ficcs/Compensation-ML?action=AttachFile&do=get&target=Compensation-ML_v1.0.24.pdf" ; a obo:IAO_0000098, owl:NamedIndividual ; rdfs:label "Compensation-ML"@en . obo:OBI_0000330 obo:IAO_0000111 "Gating-ML"@en ; obo:IAO_0000112 "foogate.xml, Gating-ML file describing gates used in a GvHD experiment."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Gating-ML is a format standard of a digital entity that is conformant with the Gating-ML standard. (http://www.flowcyt.org/gating/)"@en ; obo:IAO_0000117 "person:Jennifer Fostel"@en ; obo:IAO_0000119 "web-page:http://www.flowcyt.org/gating/" ; a obo:IAO_0000098, owl:NamedIndividual ; rdfs:label "Gating-ML"@en . obo:OBI_0000332 obo:IAO_0000111 "OWL"@en ; obo:IAO_0000112 "OBI ontology file, Basic Formal Ontology file, BIRNLex file, BioPAX file."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "OWL is a format standard of a digital entity that is conformant with the W3C Web Ontology Language specification.(http://www.w3.org/2004/OWL/)"@en ; obo:IAO_0000117 "person:Jennifer Fostel"@en ; obo:IAO_0000119 "web-page:http://www.w3.org/2004/OWL/" ; a obo:IAO_0000098, owl:NamedIndividual ; rdfs:label "OWL"@en . obo:OBI_0000338 obo:IAO_0000111 "interpreting data" ; obo:IAO_0000112 "Concluding that a gene is upregulated in a tissue sample based on the band intensity in a western blot. Concluding that a patient has a infection based on measurement of an elevated body temperature and reported headache. Concluding that there were problems in an investigation because data from PCR and microarray are conflicting. Concluding that 'defects in gene XYZ cause cancer due to improper DNA repair' based on data from experiments in that study that gene XYZ is involved in DNA repair, and the conclusion of a previous study that cancer patients have an increased number of mutations in this gene." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A planned process in which data gathered in an investigation is evaluated in the context of existing knowledge with the objective to generate more general conclusions or to conclude that the data does not allow one to draw general conclusion"@en ; obo:IAO_0000117 "PERSON: Bjoern Peters", "PERSON: Jennifer Fostel" ; obo:IAO_0000119 "Bjoern Peters" ; a owl:Class ; rdfs:label "drawing a conclusion based on data"@en ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:IAO_0000027 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001909 ] . obo:OBI_0000339 obo:IAO_0000111 "planning" ; obo:IAO_0000112 "The process of a scientist thinking about and deciding what reagents to use as part of a protocol for an experiment. Note that the scientist could be human or a \"robot scientist\" executing software." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "a process of creating or modifying a plan specification"@en ; obo:IAO_0000116 "7/18/2011 BP: planning used to itself be a planned process. Barry Smith pointed out that this would lead to an infinite regression, as there would have to be a plan to conduct a planning process, which in itself would be the result of planning etc. Therefore, the restrictions on 'planning' were loosened to allow for informal processes that result in an 'ad hoc plan '. This required changing from 'has_specified_output some plan specifiction' to 'has_participant some plan specification'." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "Bjoern Peters", "Plans and Planned Processes Branch" ; a owl:Class ; rdfs:label "planning"@en ; rdfs:subClassOf obo:BFO_0000015, [ a owl:Class ; owl:intersectionOf (obo:BFO_0000015 [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom obo:IAO_0000104 ] ) ] . obo:OBI_0000340 obo:IAO_0000111 "obsolete_documenting" ; obo:IAO_0000112 "Recording the current temperature in a laboratory notebook. Writing a journal article. Updating a patient record in a database." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "wikipedia http://en.wikipedia.org/wiki/Documenting" ; obo:IAO_0000231 obo:IAO_0000228 ; obo:IAO_0100001 obo:IAO_0000572 ; a owl:Class ; rdfs:label "obsolete_documenting" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000341 obo:IAO_0000111 "histological sample preparation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "histological sample preparation is the preparation of an input tissue via slicing and labeling to make tissue microstructure of interest visible in a future histology assay"@en ; obo:IAO_0000117 "PERSON:Bjoern Peters"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "histological sample preparation"@en ; rdfs:subClassOf obo:OBI_0000094, obo:OBI_0000659, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100066 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000684 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom obo:OBI_0400168 ] . obo:OBI_0000343 obo:IAO_0000111 "inductive reasoning" ; obo:IAO_0000112 "Based on the observation that all lung cancer patients treated with aspirin in our clinical trial survived longer than the control group, we conclude by inductive reasining that aspirin has a therapeutic effect on lung cancer."@en ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "a interpreting data that is used to ascribe properties or relations to types based on an observation instance (i.e., on a number of observations or experiences); or to formulate laws based on limited observations of recurring phenomenal patterns."@en ; obo:IAO_0000116 """BP: 10/22/122: After changing the parent class to drawing a conclusion *based on data* it is no longer clear that this class is needed; minimally it needs a better definition to distinguish it. Proposal is to obsolete.""" ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "wikipedia: http://en.wikipedia.org/wiki/Inductive_reasoning" ; a owl:Class ; rdfs:label "inductive reasoning"@en ; rdfs:subClassOf obo:OBI_0000338 . obo:OBI_0000345 obo:IAO_0000111 "mass analyzer" ; obo:IAO_0000112 "The mass analyzer of the Voyager-DE(tm) STR Biospectrometry Workstation" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Mass analyzer is a device that separates ions according to their mass-to-charge ratio. All mass spectrometers are based on dynamics of charged particles in electric and magnetic fields in vacuum where the two laws of Lorentz force law and Newton's second law of motion apply." ; obo:IAO_0000117 "Frank Gibson", "PERSON: Daniel Schober" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Mass_spectrometry#Mass_analyzer" ; a owl:Class ; rdfs:label "mass analyzer" ; rdfs:subClassOf obo:OBI_0000832, obo:OBI_0000932, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000372 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000355 obo:IAO_0000111 "hypothesis driven investigation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "is an investigation with the goal to test one or more hypothesis"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "hypothesis driven investigation"@en ; rdfs:subClassOf obo:OBI_0000066 . obo:OBI_0000356 obo:IAO_0000111 "hypothesis generating investigation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "is an investigation in which data is generated and analyzed with the purpose of generating new hypothesis"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "hypothesis generating investigation"@en ; rdfs:subClassOf obo:OBI_0000066 . obo:OBI_0000361 obo:IAO_0000111 "ion source" ; obo:IAO_0000112 "The ion source of a Voyager-DE??? STR Biospectrometry Workstation" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An ion source is a device that is part of a mass spectrometer that ionizes the material under analysis. The ions are then transported by magnetic or electric fields to the mass analyzer. Techniques for ionization have been key to determining what types of samples can be analyzed by mass spectrometry. Electron ionization and chemical ionization are used for gases and vapors. In chemical ionization sources, the material is ionized by chemical ion-molecule reactions during collisions in the source. Two techniques often used with liquid and solid biological samples include electrospray ionization (due to John Fenn PMID 2675315.) and matrix-assisted laser desorption/ionization (MALDI, due to M. Karas and F. Hillenkamp (Measuring Mass: From Positive Rays to Proteins by Michael A. Grayson (Editor) (ISBN 0-941901-31-9)))." ; obo:IAO_0000117 "Frank Gibson" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Mass_spectrometry#Ion_source" ; a owl:Class ; rdfs:label "ion source" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000385 ] . obo:OBI_0000364 obo:IAO_0000111 "ion detector" ; obo:IAO_0000112 "The ion detector of the Voyager-DE(tm) STR Biospectrometry Workstation" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An ion detector is a device that measures and records the charge induced or current produced when an ion passes by or hits a surface. Example: In a scanning instrument the signal produced in the detector during the course of the scan versus where the instrument is in the scan (at what m/Q) will produce a mass spectrum, a record of ions as a function of m/Q." ; obo:IAO_0000117 "Frank Gibson" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Mass_spectrometry#Detector" ; a owl:Class ; rdfs:label "ion detector" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000365 obo:IAO_0000111 "obsolete_results_from" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000116 """2009/11/23: BP, dev call:o bsoleted as discussed in tracker https://sourceforge.net/tracker/?func=detail&aid=2899860&group_id=177891&atid=886178 . Should be replaced by instead creating defined classes for materials, which are specified output of the process that conveys the""" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:ObjectProperty ; rdfs:label "obsolete_results_from" ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:OBI_0000366 obo:IAO_0000111 "metabolite profiling assay" ; obo:IAO_0000112 "Metabolite profiling of human colon carcinoma - deregulation of TCA cycle and amino acid turnover. Mol Cancer. 2008 Sep 18;7(1):72. PMID: 18799019" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that detects and identifies chemical entities resulting from biochemical and cellular metabolism" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "metabolite assay", "metabolomic assay" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "metabolite profiling assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100051 ] . obo:OBI_0000367 obo:IAO_0000111 "light emission function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A light emission function is an excitation function to excite a material to a specific excitation state that it emits light."@en ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; a owl:Class ; rdfs:label "light emission function"@en ; rdfs:subClassOf obo:OBI_0000374 . obo:OBI_0000368 obo:IAO_0000111 "record function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A record function is a function that registers or collects information in a particular format on a particular recording medium. For example on paper or a digital representation"@en ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; a owl:Class ; rdfs:label "record function"@en ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000369 obo:IAO_0000111 "magnify function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A magnify function is a function to increase the size of a transmitted object image through the precise arrangement of energy diffraction elements along an imaging path."@en ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; a owl:Class ; rdfs:label "magnify function"@en ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000370 obo:IAO_0000111 "contain function"@en ; obo:IAO_0000112 "A syringe, a beaker" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A contain function is a function to constrain a material entities location in space"@en ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; a owl:Class ; rdfs:label "contain function"@en ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000371 obo:IAO_0000111 "heat function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A heat function is a function that increases the internal kinetic energy of a material"@en ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; a owl:Class ; rdfs:label "heat function"@en ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000372 obo:IAO_0000111 "material separation function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A material separation function is a function that increases the resolution between two or more material entities. The to distinction between the entities is usually based on some associated physical quality."@en ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; a owl:Class ; rdfs:label "material separation function"@en ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000373 obo:IAO_0000111 "ionize process" ; obo:IAO_0000112 "Electrospray ionization in mass spectrometry" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a physical process of converting an atom or molecule into an ion by adding or removing charged particles such as electrons or other ions. This excludes chemical processes of dissociation." ; obo:IAO_0000116 "2009-11-10. Tracker: http://en.wikipedia.org/wiki/Ionize" ; obo:IAO_0000117 "Person:Bjoern Peters" ; a owl:Class ; rdfs:label "ionize process"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_0000385 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom obo:BFO_0000002 ] . obo:OBI_0000374 obo:IAO_0000111 "excitation function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A excitation function is a function to inject energy by bombarding a material with energetic particles (e.g., photons) thereby imbuing internal material components such as electrons with additional energy. These internal, 'excited' particles may lead to the rupturing of covalent chemical bonds or may quickly relax back to there unexcited state with an exponential time course thereby locally emitting energy in the form of photons."@en ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; a owl:Class ; rdfs:label "excitation function"@en ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000375 obo:IAO_0000111 "freeze function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A freeze function is a function to decrease the internal kinetic energy of a material below the freezing point of that type of material."@en ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; a owl:Class ; rdfs:label "freeze function"@en ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000376 obo:IAO_0000111 "synthesizing function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A synthesizing function is a function to assemble new output materials from distinct input materials. The output materials typically consist of chemically distinct monomeric objects or object aggregate polymers." ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; a owl:Class ; rdfs:label "synthesizing function"@en ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000377 obo:IAO_0000111 "perturb function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A perturb function is a function that disrupts the normal function of a system induced through either internal or external means. External means of perturbation include: (1) displacement fields in the physical sense - e.g., temperature change, osmotic shock, pressure change; (2) application of small molecules such as drugs or toxins to perturb the function of specific pathways or application of surfactants to perturb the normal function of plasma membrane. Internal means of perturbation include: (1) manipulation of gene function via gene knockout or transcript knockdown via RNAi; (2) directed genetic mutation leading to minimal aa alterations that interfere with peptide function."@en ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Perturbation_biology"@en ; a owl:Class ; rdfs:label "perturb function"@en ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000378 obo:IAO_0000111 "filter function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A filter function is a function to prevent the flow of certain entities based on a quality or qualities of the entity while allowing entities which have different qualities to pass through"@en ; obo:IAO_0000117 "Frank Gibson" ; a owl:Class ; rdfs:label "filter function"@en ; rdfs:subClassOf obo:OBI_0000372 . obo:OBI_0000379 obo:IAO_0000111 "mechanical function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A mechanical function is a function that is realised via mechanical work (through an certain amount of energy transferred by some force)."@en ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Mechanical_work"@en ; a owl:Class ; rdfs:label "mechanical function"@en ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000380 obo:IAO_0000111 "gas filter function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A gas filter function is a filter function which prevents the flow of solid objects, defined by specific qualities, in a gas-solid mixture"@en ; obo:IAO_0000117 "Frank Gibson" ; a owl:Class ; rdfs:label "gas filter function"@en ; rdfs:subClassOf obo:OBI_0000378 . obo:OBI_0000381 obo:IAO_0000111 "liquid filter function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A liquid filter function is a filter function which prevents the flow of solid objects, defined by specific qualities, in a liquid-solid mixture"@en ; obo:IAO_0000117 "Frank Gibson" ; a owl:Class ; rdfs:label "liquid filter function"@en ; rdfs:subClassOf obo:OBI_0000378 . obo:OBI_0000383 obo:IAO_0000111 "transfer function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A transfer function is a function to displace a material from one location to another."@en ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; a owl:Class ; rdfs:label "transfer function"@en ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000384 obo:IAO_0000111 "electricity supply function"@en ; obo:IAO_0000112 "the function of supplying current during a neuroscience experiment." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An electricity supply function is an energy supply function to transfer electricity from one source to another, typically a consumer of the electricity or as a stimulus during a neuroscience experiment."@en ; obo:IAO_0000117 "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; obo:IAO_0000118 "power supply"@en ; a owl:Class ; rdfs:label "electricity supply function"@en ; rdfs:subClassOf obo:OBI_0000391 . obo:OBI_0000385 obo:IAO_0000111 "ionization function"@en ; obo:IAO_0000112 "The ion source in amass spectrometer" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An ionization function is a function to physically convert an atom or molecule into an ion by adding or removing charged particles such as electrons or other ions."@en ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Ionization"@en ; a owl:Class ; rdfs:label "ionization function"@en ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000387 obo:IAO_0000111 "cool function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A cool function is a function to decrease the internal kinetic energy of a material below the initial kinetic energy of that type of material."@en ; obo:IAO_0000117 "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; a owl:Class ; rdfs:label "cool function"@en ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000388 obo:IAO_0000111 "connection function"@en ; obo:IAO_0000112 "An electricity cable" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A connection function is a function to couple two or more flow channels so that material or signals can be transported from one set of channels to another."@en ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; a owl:Class ; rdfs:label "connection function"@en ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000389 obo:IAO_0000111 "isoelectric focusing device" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An isoelectric focusing device is a device in which isoelectric focusing can be performed. An isoelectric focussing device had the function to contain and control the contained environment and transfer electrical energy from a power supply to a separation medium and the charged material to be separated." ; obo:IAO_0000117 "Frank Gibson" ; obo:IAO_0000118 "isoelectric focusing unit" ; obo:IAO_0000119 "sep:00097" ; a owl:Class ; rdfs:label "isoelectric focusing device" ; rdfs:subClassOf obo:OBI_0002089, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000370 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000383 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000401 ] . obo:OBI_0000390 obo:IAO_0000111 "thermostatic circulator" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A thermostatic circulator is a device which cools or heats a circulating liquid. It has the function to contain control the contained environment and transfer energy from or to the circulating liquid" ; obo:IAO_0000117 "Frank Gibson" ; obo:IAO_0000119 "sep:00098" ; a owl:Class ; rdfs:label "thermostatic circulator" ; rdfs:subClassOf obo:OBI_0002089, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000370 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000401 ] . obo:OBI_0000391 obo:IAO_0000111 "energy supply function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An energy supply function is a function to supply or transfer energy from an energy source to a consumer of the energy"@en ; obo:IAO_0000117 "Frank Gibson" ; a owl:Class ; rdfs:label "energy supply function"@en ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000392 obo:IAO_0000111 "information processor function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An information processor function is a function that converts information from one form to another, by a lossless process or an extraction process."@en ; obo:IAO_0000117 "Frank Gibson" ; obo:IAO_0000118 "data processor function"@en ; a owl:Class ; rdfs:label "information processor function"@en ; rdfs:subClassOf obo:BFO_0000034, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000453 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000455 ] . obo:OBI_0000393 obo:IAO_0000111 "signal conversion function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A signal conversion function is an information processor function which transforms a signal into another type of signal. For example an analog-to-digital_converter, Ac/Ac converter, a synapse converts electrical action potentials into an intermediate chemical signal. The post synapse converts it back into an electric one passed on to the axon."@en ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; obo:IAO_0000118 "transduction function" ; a owl:Class ; rdfs:label "signal conversion function"@en ; rdfs:subClassOf obo:OBI_0000392 . obo:OBI_0000394 obo:IAO_0000111 "blot module" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A blot module is a device which has the function to conatin and facilitate the material transfer process blotting to be realised" ; obo:IAO_0000117 "Frank Gibson" ; obo:IAO_0000119 "sep:00092" ; a owl:Class ; rdfs:label "blot module" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000383 ] . obo:OBI_0000395 obo:IAO_0000111 "signal amplification function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A signal amplification function is a signal conversion function to inject energy into an input signal so as to produce an output signal with increased differential magnitude while also seeking to minimize increases in the signal to noise ratio. For example, to produce a 0.1 KW output signal from a 1 mW RMS input signal."@en ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; a owl:Class ; rdfs:label "signal amplification function"@en ; rdfs:subClassOf obo:OBI_0000393 . obo:OBI_0000397 obo:IAO_0000111 "image acquisition function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An image acquisition function is a function to acquire an image of a material"@en ; obo:IAO_0000117 "Frank Gibson" ; a owl:Class ; rdfs:label "image acquisition function"@en ; rdfs:subClassOf obo:OBI_0000453, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000398 ], [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0001007 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000398 obo:IAO_0000111 "image acquisition device" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An image creation device is a device which captures a digitized image of an object" ; obo:IAO_0000117 "Frank Gibson" ; obo:IAO_0000118 "image acquisition device" ; obo:IAO_0000119 "sep:00096" ; a owl:Class ; rdfs:label "image creation device" ; rdfs:subClassOf obo:OBI_0000832 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000968 [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000397 ] ) ] . obo:OBI_0000399 obo:IAO_0000111 "solid support function" ; obo:IAO_0000112 "Taped, glued, pinned, dried or molecularly bonded to a solid support" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A solid support function is a function of a device on which an entity is kept in a defined position and prevented in its movement"@en ; obo:IAO_0000117 "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; a owl:Class ; rdfs:label "solid support function"@en ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000400 obo:IAO_0000111 "display function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A display function is a function to present information by translating that information through some lookup process into visual form."@en ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; a owl:Class ; rdfs:label "display function"@en ; rdfs:subClassOf obo:OBI_0000392 . obo:OBI_0000401 obo:IAO_0000111 "environment control function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An environmental control function is a function that regulates a contained environment within specified parameter ranges. For example the control of light exposure, humidity and temperature."@en ; obo:IAO_0000117 "Bill Bug", "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; a owl:Class ; rdfs:label "environment control function"@en ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000403 obo:IAO_0000111 "sort function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A sort function is a function to distinguish material components based on some associated physical quality or entity and to partition the separate components into distinct fractions according to a defined order."@en ; obo:IAO_0000117 "Daniel Schober", "Frank Gibson", "Melanie Courtot" ; a owl:Class ; rdfs:label "sort function"@en ; rdfs:subClassOf obo:OBI_0000372 . obo:OBI_0000404 obo:IAO_0000111 "gel dryer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A gel dryer is a device which has the function to contain and to control the contained environment to facilitate the drying of gels" ; obo:IAO_0000117 "Frank Gibson" ; obo:IAO_0000119 "sep:00094" ; a owl:Class ; rdfs:label "gel dryer" ; rdfs:subClassOf obo:OBI_0002089, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000370 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000401 ] . obo:OBI_0000405 obo:IAO_0000111 "primer role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a complementary nucleotide probe role which inheres in nucleic acid molecular entity and is realized by the use of the entity bearing the role to initiate chain elongation." ; obo:IAO_0000119 "(cell and molecular biology) A short strand of RNA that is synthesized along single-stranded DNA during replication, initiating DNA polymerase-catalyzed synthesis of the complementary strand. http://www.answers.com/topic/rna-primer" ; a owl:Class ; rdfs:label "primer role"@en ; rdfs:subClassOf obo:OBI_0000857, [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0000415 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000406 obo:IAO_0000111 "PCR product"@en ; obo:IAO_0000112 "PCR products are the results of amplifcation process. Detection of a PCR products is used to detect DNA and RNA." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "is double stranded DNA that is the specified output of a polymerase chain reaction"@en ; obo:IAO_0000116 "We are using PCR and not the written out words, as this is the most common used."@en ; obo:IAO_0000117 "GROUP: OBI BIomaterial Branch" ; obo:IAO_0000119 "GROUP: OBI BIomaterial Branch" ; a owl:Class ; rdfs:label "PCR product"@en ; rdfs:subClassOf obo:CHEBI_4705, obo:OBI_0000809 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CHEBI_4705 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000415 ] ) ] . obo:OBI_0000407 obo:IAO_0000111 "viral RNA extraction" ; obo:IAO_0000112 "The AccuPrepTM Viral RNA Extraction Kit is designed for the rapid and convenient extraction of viral RNA from cell-free samples as serum, plasma, CSF, urine, etc - http://www.biokits.com/moreinfos.html?id=2703" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The extraction of RNA from an input material that specifically isolates viral RNA" ; obo:IAO_0000117 "Person:Bjoern Peters" ; a owl:Class ; rdfs:label "viral RNA extraction"@en ; rdfs:subClassOf obo:OBI_0666666, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:NCBITaxon_10239 ] . obo:OBI_0000409 obo:IAO_0000111 "nucleic acid template role" ; obo:IAO_0000112 "a model or standard for making comparisons; wordnet.princeton.edu/perl/webwn 19 feb 2009" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a reference substance role which inheres in nucleic acid material entity and is realized in the process of using the nucleic acid bearing the template role as a reference during synthesis of a reverse copy." ; a owl:Class ; rdfs:label "nucleic acid template role"@en ; rdfs:subClassOf obo:OBI_0000025, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33696 ], [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0000415 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000410 obo:IAO_0000111 "recombinant plasmid"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a plasmid in which extraneous DNA has been inserted." ; obo:IAO_0000117 "PERSON: Bjoern Peters", "PERSON: Kevin Clancy", "PERSON: Melanie Courtot" ; obo:IAO_0000119 "GROUP: OBI Biomaterial Branch" ; a owl:Class ; rdfs:label "recombinant plasmid"@en ; rdfs:subClassOf obo:OBI_0000430, obo:OBI_0000731 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000430 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600064 ] ) ] . obo:OBI_0000411 obo:IAO_0000111 "cloning vector role" ; obo:IAO_0000112 "pBluescript plays the role of a cloning vector" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A material to be added role played by a small, self-replicating DNA or RNA molecule - usually a plasmid or chromosome - and realized in a process whereby foreign DNA or RNA is inserted into the vector during the process of cloning."@en ; obo:IAO_0000116 "JZ: related tracker: https://sourceforge.net/p/obi/obi-terms/102/" ; obo:IAO_0000117 "PERSON: Helen Parkinson" ; a owl:Class ; rdfs:label "cloning vector role"@en ; rdfs:subClassOf obo:OBI_0000319, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33696 ] [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0600064 ; owl:onProperty obo:BFO_0000054 ] ) ] . obo:OBI_0000413 obo:IAO_0000111 "cell cycle synchronization" ; obo:IAO_0000112 "Elimination of serum from the culture medium for about 24 hours results in the accumulation of cells at G1 phase. This effect of nutritional deprivation can be restored by their addition by which time the cell synchrony occurs."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a process with the objective to obtain a cell culture in which all cells are in the same stage of the cell cycle"@en ; obo:IAO_0000117 "OBI PA" ; obo:IAO_0000119 "Bjoern Peters and Nicole Washington" ; a owl:Class ; rdfs:label "cell cycle synchronization"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100060 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0100060 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0000415 obo:IAO_0000111 "polymerase chain reaction" ; obo:IAO_0000112 "Opisthorchis viverrini: Detection by polymerase chain reaction (PCR) in human stool samples. Exp Parasitol. 2008 Sep 9. PMID: 18805413"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "PCR is the process in which a DNA polymerase is used to amplify a piece of DNA by in vitro enzymatic replication. As PCR progresses, the DNA thus generated is itself used as a template for replication. This sets in motion a chain reaction in which the DNA template is exponentially amplified."@en ; obo:IAO_0000117 "OBI Plan" ; obo:IAO_0000118 "PCR"@en ; obo:IAO_0000119 "adapted from wikipedai" ; a owl:Class ; rdfs:label "polymerase chain reaction"@en ; rdfs:subClassOf obo:OBI_0600058, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000376 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042575 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16991 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000406 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0000416 obo:IAO_0000111 "cloning insert role" ; obo:IAO_0000114 obo:IAO_0000121 ; obo:IAO_0000115 "cloning insert role is a role which inheres in DNA or RNA and is realized by the process of being inserted into a cloning vector in a cloning process."@en ; obo:IAO_0000116 "Feb 20, 2009. from Wikipedia: cloning of any DNA fragment essentially involves four steps: DNA fragmentation with restriction endonucleases, ligation of DNA fragments to a vector, transfection, and screening/selection. There are multiple processes involved, it is not just \"cloning process\"" ; obo:IAO_0000117 "GROUP: Role branch" ; obo:IAO_0000119 "OBII and Wikipedia" ; a owl:Class ; rdfs:label "cloning insert role"@en ; rdfs:subClassOf obo:BFO_0000023 . obo:OBI_0000417 obo:IAO_0000111 "achieves_planned_objective" ; obo:IAO_0000112 "A cell sorting process achieves the objective specification 'material separation objective'" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process." ; obo:IAO_0000117 "BP, AR, PPPB branch" ; obo:IAO_0000119 "PPPB branch derived" ; obo:IAO_0000232 "modified according to email thread from 1/23/09 in accordince with DT and PPPB branch" ; a owl:ObjectProperty ; rdfs:domain obo:OBI_0000011 ; rdfs:label "achieves_planned_objective" ; rdfs:range obo:IAO_0000005 ; owl:inverseOf obo:OBI_0000833 . obo:OBI_0000418 obo:IAO_0000111 "measuring glucose concentration in blood serum assay" ; obo:IAO_0000112 "Measuring glucose concentration in blood from a mouse. See Figure 2 of the 2016 OBI paper, PMID: 27128319." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay that determines the concentration of glucose molecules in a blood serum sample" ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "measuring glucose concentration in blood serum assay" ; rdfs:subClassOf obo:OBI_2100020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0100017 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100017 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] . obo:OBI_0000419 obo:IAO_0000111 "reverse transcriptase"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 """enzyme and has_function some GO:0003964 (RNA-directed DNA polymerase activity)"""@en ; obo:IAO_0000117 "person:Melanie Courtot" ; obo:IAO_0000119 "group:OBI" ; a owl:Class ; rdfs:label "reverse transcriptase"@en ; rdfs:subClassOf obo:OBI_0000427 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000427 [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom [ a owl:Restriction ; owl:allValuesFrom obo:GO_0003964 ; owl:onProperty obo:BFO_0000054 ] ] ) ] . obo:OBI_0000420 obo:IAO_0000111 "obsolete_trypsinized material" ; obo:IAO_0000112 "A trypsinized suspension of cells" ; obo:IAO_0000114 obo:IAO_0000002 ; obo:IAO_0000115 "A material entity that has undergone a process of digestion with trypsin" ; obo:IAO_0000117 "Person:Bjoern Peters" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_trypsinized material" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000422 obo:IAO_0000111 "syringe" ; obo:IAO_0000112 "Accuracy of oral liquid measuring devices: comparison of dosing cup and oral dosing syringe.Ann Pharmacother. 2008 Jan;42(1):46-52. Epub 2007 Dec 4. PMID: 18056832" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A processed material which is used to introduce or draw fluids from a material entity. A syringe is made of a piston and body. the movement of the piston in the body determines the amount/volume of fluid to inject or draw" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "OBI Instrument adapted from Wikipedia" ; a owl:Class ; rdfs:label "syringe" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000383 ] . obo:OBI_0000423 obo:IAO_0000111 "extract"@en ; obo:IAO_0000112 "Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer. Cancer Res. 2008 Oct 15;68(20):8489-98. PMID: 18922923"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "an extract is a material entity which results from an extraction process"@en ; obo:IAO_0000117 "PERSON: Philippe Rocca-Serra" ; obo:IAO_0000118 "extracted material"@en ; obo:IAO_0000119 "GROUP: OBI Biomatrial Branch" ; a owl:Class ; rdfs:label "extract"@en ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0302884 ] . obo:OBI_0000424 obo:IAO_0000111 "transcription profiling assay" ; obo:IAO_0000112 "Whole genome transcription profiling of Anaplasma phagocytophilum in human and tick host cells by tiling array analysis. BMC Genomics. 2008 Jul 31;9:364. PMID: 18671858" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that determines gene expression and transcription activity using ribonucleic acids collected from a material entity." ; obo:IAO_0000116 "This term should encompass transcription and post-transcription, but before translation into protein. So 'gene expression' itself is too broad, and we use 'transcription profiling identification objective' to constrain the scope of this term." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "gene expression profiling", "transcription profiling" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "transcription profiling assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000880 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000880 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33697 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33697 ] ) ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33697 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0010467 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001331 ] ) ] . obo:OBI_0000425 obo:IAO_0000111 "averaging objective"@en ; obo:IAO_0000112 "A mean calculation which has averaging objective is a descriptive statistics calculation in which the mean is calculated by taking the sum of all of the observations in a data set divided by the total number of observations. It gives a measure of the 'center of gravity' for the data set. It is also known as the first moment."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An averaging objective is a data transformation objective where the aim is to perform mean calculations on the input of the data transformation."@en ; obo:IAO_0000117 "Elisabetta Manduchi", "James Malone"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi" ; a owl:Class ; rdfs:label "averaging objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0000426 obo:IAO_0000111 "injection" ; obo:IAO_0000112 "Multiple Small-Dose Injections Can Reduce the Passage of Sclerosant Foam into Deep Veins During Foam Sclerotherapy for Varicose Veins. Eur J Vasc Endovasc Surg. 2008 Oct 13. PMID: 18922712"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "injection is process which aims at introducing a compound or a mixture into a material entity (either biological entity or instrument) by relying on devices such as syringe or injector connection, attached or forced into a vascular system (veins of an organism or tubes of a machine) or in a tissue."@en ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "OBI Biomaterial" ; a owl:Class ; rdfs:label "injection"@en ; rdfs:subClassOf obo:OBI_0000274, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000434 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_0000319 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000422 ] ) ] ] ) ] . obo:OBI_0000427 obo:IAO_0000111 "enzyme"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 """(protein or rna) or has_part (protein or rna) and has_function some GO:0003824 (catalytic activity)"""@en ; obo:IAO_0000116 """MC: known issue: enzyme doesn't classify under material entity for now as it isn't stated that anything that has_part some material entity is a material entity. If we add as equivalent classes to material entity has_part some material entity and part_of some material entity (each one in his own necessary and sufficient block) Pellet in P3 doesn't classify any more.""" ; obo:IAO_0000117 "person: Melanie Courtot" ; obo:IAO_0000119 "GROUP:OBI" ; a owl:Class ; rdfs:label "enzyme"@en ; rdfs:subClassOf obo:BFO_0000040 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Class ; owl:unionOf (obo:CHEBI_33697 obo:GO_0032991 obo:PR_000000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33697 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0032991 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000000001 ] ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom [ a owl:Restriction ; owl:allValuesFrom obo:GO_0003824 ; owl:onProperty obo:BFO_0000054 ] ] ) ] . obo:OBI_0000429 obo:IAO_0000111 "intraperitoneal administration" ; obo:IAO_0000112 "Rats were injected intraperitoneally with either rrIL-6 (250 ng/0.5 ml) or equal-volume sterile saline twice within an interval of 24 h" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The administration of a substance into the peritoneum of an organism" ; obo:IAO_0000117 "Person:Bjoern Peters" ; a owl:Class ; rdfs:label "intraperitoneal administration" ; rdfs:subClassOf obo:OBI_0600007 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000319 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0002358 ] ) ] ] ) ] . obo:OBI_0000430 obo:IAO_0000111 "plasmid"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 """plasmid = DNA and has_quality circular and has_function (is_realized_as some gene expression) GO:0010467"""@en ; obo:IAO_0000117 "person:Melanie Courtot" ; obo:IAO_0000119 "group:OBI" ; a owl:Class ; rdfs:label "plasmid"@en ; rdfs:subClassOf obo:CHEBI_4705 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CHEBI_4705 [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom [ a owl:Restriction ; owl:allValuesFrom obo:GO_0010467 ; owl:onProperty obo:BFO_0000054 ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:SO_0000988 ] ) ] . obo:OBI_0000431 obo:IAO_0000111 "injection into organ section" ; obo:IAO_0000112 "Staining a specimen of human lung tissue with hematoxylin and eosin in order as a preparative step in histology" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A process in which an input substance is injected into a organ section." ; obo:IAO_0000117 "Person:Bjoern Peters" ; a owl:Class ; rdfs:label "injection into organ section"@en ; rdfs:subClassOf obo:OBI_0000426, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000434 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_0000319 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000422 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0100066 ] ) ] ] ) ] . obo:OBI_0000432 obo:IAO_0000111 "polyacrylamide gel"@en ; obo:IAO_0000112 "Assessing CMT cell line stability by two dimensional polyacrylamide gel electrophoresis and mass spectrometry based proteome analysis. J Proteomics. 2008 Jul 21;71(2):160-7. PMID: 18617143"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a material entity resulting from the polymerization of acrylamide with TEMED in some buffer solution"@en ; obo:IAO_0000117 "PERSON: Jie Zheng", "PERSON: Philippe Rocca-Serra" ; obo:IAO_0000119 "GROUP: OBI Biomaterial Branch" ; a owl:Class ; rdfs:label "polyacrylamide gel"@en ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_28619 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0302890 ] . obo:OBI_0000433 obo:IAO_0000111 "DNA sequence feature detection assay" ; obo:IAO_0000112 "genotyping using an Affymetrix chip" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay with the objective to determine a sequence feature of DNA" ; obo:IAO_0000117 "Bjoern Peters", "Philippe Rocca-Serra" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "DNA sequence feature detection assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000113 ] . obo:OBI_0000434 obo:IAO_0000111 "adding material objective" ; obo:IAO_0000112 "creating a mouse infected with LCM virus" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "is the specification of an objective to add a material into a target material. The adding is asymmetric in the sense that the target material largely retains its identity"@en ; obo:IAO_0000117 "BP" ; a owl:Class ; rdfs:label "adding material objective"@en ; rdfs:subClassOf obo:OBI_0000686 . obo:OBI_0000435 obo:IAO_0000111 "genotyping assay" ; obo:IAO_0000112 "High-throughput genotyping of oncogenic human papilloma viruses with MALDI-TOF mass spectrometry. Clin Chem. 2008 Jan;54(1):86-92. Epub 2007 Nov 2.PMID: 17981923" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay which generates data about a genotype from a specimen of genomic DNA. A variety of techniques and instruments can be used to produce information about sequence variation at particular genomic positions." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "SNP analysis", "genotype profiling" ; obo:IAO_0000119 "OBI Biomaterial" ; a owl:Class ; rdfs:label "genotyping assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_16991 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001305 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000113 ] . obo:OBI_0000436 obo:IAO_0000111 "needle" ; obo:IAO_0000112 "Ovarian carcinoma presenting with axillary lymph node metastasis: A case diagnosed by fine-needle aspiration and brief review of the literature. Diagn Cytopathol. 2008 Oct 16. PMID: 18925569" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A needle is a sharp, hollow device used to penetrate tissue or soft material. When attached to a syringe. it allows delivery of a specific volume of liquid or gaseous mixture." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "OBI Instrument" ; a owl:Class ; rdfs:label "needle" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000383 ] . obo:OBI_0000437 obo:IAO_0000111 "analyte measurement objective" ; obo:IAO_0000112 "The objective to measure the concentration of glucose in a blood sample" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "an assay objective to determine the presence or concentration of an analyte in the evaluant"@en ; obo:IAO_0000117 "PERSON: Bjoern Peters" ; obo:IAO_0000119 "PPPB branch" ; a owl:Class ; rdfs:label "analyte measurement objective"@en ; rdfs:subClassOf obo:OBI_0000441 . obo:OBI_0000438 obo:IAO_0000111 "DNA sequence variation detection assay" ; obo:IAO_0000112 "Capturing genomic signatures of DNA sequence variation using a standard anonymous microarray platform. Nucleic Acids Res. 2006;34(18):e121. PMID: 17000641" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An assay that measures changes (expansion, amplification, deletion, mutation) in the sequence of a DNA molecule." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "OBI Biomaterial" ; a owl:Class ; rdfs:label "DNA sequence variation detection assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001051 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000113 ] . obo:OBI_0000439 obo:IAO_0000111 "agarose gel"@en ; obo:IAO_0000112 "Performance comparison of capillary and agarose gel electrophoresis for the identification and characterization of monoclonal immunoglobulins. Am J Clin Pathol. 2008 Mar;129(3):451-8. PMID: 18285269"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a material entity resulting from the polymerization of agarose after heating agarose suspended in some buffer solution"@en ; obo:IAO_0000117 "PERSON: Philippe Rocca-Serra" ; obo:IAO_0000119 "GROUP: OBI Biomaterial Branch" ; a owl:Class ; rdfs:label "agarose gel"@en ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0302890 ] . obo:OBI_0000441 obo:IAO_0000111 "assay objective" ; obo:IAO_0000112 "the objective to determine the weight of a mouse." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "an objective specification to determine a specified type of information about an evaluated entity (the material entity bearing evaluant role)"@en ; obo:IAO_0000117 "PPPB branch" ; obo:IAO_0000119 "PPPB branch" ; a owl:Class ; rdfs:label "assay objective"@en ; rdfs:subClassOf obo:IAO_0000005 . obo:OBI_0000442 obo:IAO_0000111 "obsolete_heart" ; obo:IAO_0000112 "Alan Ruttenberg's heart" ; obo:IAO_0000114 obo:IAO_0000002 ; obo:IAO_0000115 "The heart is a muscular organ found in all vertebrates that is responsible for pumping blood throughout the blood vessels by repeated, rhythmic contractions" ; obo:IAO_0000117 "Person:Bjoern Peters" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Heart" ; obo:IAO_0000231 obo:IAO_0000230 ; a owl:Class ; rdfs:label "obsolete_heart" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000443 obo:IAO_0000111 "analyte assay" ; obo:IAO_0000112 "example of usage: In lab test for blood glucose, the test is the assay, the blood bears evaluant_role and glucose bears the analyte role. The evaluant is considered an input to the assay and the information entity that records the measurement of glucose concentration the output" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An assay with the objective to capture information about the presence, concentration, or amount of an analyte in an evaluant." ; obo:IAO_0000117 "Alan Ruttenberg", "Bjoern Peters", "Helen Parkinson", "Philippe Rocca-Serra" ; obo:IAO_0000119 "Alan Ruttenberg", "Bjoern Peters", "Helen Parkinson", "OBI Planned process branch", "Philippe Rocca-Serra" ; a owl:Class ; rdfs:label "analyte assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000437 ] . obo:OBI_0000444 obo:IAO_0000111 "target of material addition role" ; obo:IAO_0000112 "peritoneum of an animal receiving an interperitoneal injection; solution in a tube receiving additional material; location of absorbed material following a dermal application." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A role of a material entity that is realized in an \"adding a material entity into a target\" process where the bearer of the role (the target) receives the addition of another material entity." ; obo:IAO_0000116 "From Branch discussion with BP, AR, MC -- there is a need for the recipient to interact with the administered material. for example, a tooth receiving a filling was not considered to be a target role." ; obo:IAO_0000117 "GROUP: Role Branch" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "target of material addition role"@en ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:BFO_0000040 ], [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0000274 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000445 obo:IAO_0000111 "mass measurement assay" ; obo:IAO_0000112 "The patients was weighed and mass was determined to be 47 kilograms" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that determines the mass of an evaluant" ; obo:IAO_0000117 "Helen Parkinson" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "mass measurement assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:BFO_0000040 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000414 ] . obo:OBI_0000446 obo:IAO_0000111 "obsolete_identification" ; obo:IAO_0000112 "DNA cleavage assay for the identification of topoisomerase I inhibitors. Nat Protoc. 2008;3(11):1736-50. PMID: 18927559" ; obo:IAO_0000114 obo:IAO_0000124 ; obo:IAO_0000115 "a process by which the identity (what a thing is) of a material entity is established within a certain confidence interval" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_identification" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000447 obo:IAO_0000111 "intracellular electrophysiology recording assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An electrophysiology assay where the recording location of the electrode is intracellular." ; obo:IAO_0000117 "Frank Gibson" ; obo:IAO_0000119 "Frank Gibson" ; a owl:Class ; rdfs:label "intracellular electrophysiology recording assay" ; rdfs:subClassOf obo:OBI_0002176, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000414 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0005216 ] ] . obo:OBI_0000448 obo:IAO_0000111 "packed column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A packed column is a chromatography column where the particles of the solid stationary phase or the support coated with a liquid stationary phase may fill the whole inside volume of the tube." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01218" ; a owl:Class ; rdfs:label "packed column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000449 obo:IAO_0000111 "obsolete_defined_output" ; obo:IAO_0000112 "example of subclass: normalized data set - A normalized data set is a data set that is produced as the output of a normalization data transformation." ; obo:IAO_0000114 obo:IAO_0000121 ; obo:IAO_0000115 "This is only a placeholder for defined classes, as are its siblings _defined_material and _defined protocol application. Its children should be defined classes constructed as output of a process." ; obo:IAO_0000117 "PERSON: Alan Ruttenberg", "PERSON: James Malone", "PERSON: Melanie Courtot" ; obo:IAO_0000231 obo:IAO_0000226 ; a owl:Class ; rdfs:label "obsolete_defined_output" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000450 obo:IAO_0000111 "regulatory agency"@en ; obo:IAO_0000112 "The US Environmental Protection Agency" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A regulatory agency is a organization that has responsibility over or for the legislation (acts and regulations) for a given sector of the government."@en ; obo:IAO_0000117 "GROUP: OBI Biomaterial Branch" ; obo:IAO_0000119 "WEB: en.wikipedia.org/wiki/Regulator" ; a owl:Class ; rdfs:label "regulatory agency"@en ; rdfs:subClassOf obo:OBI_0000245 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000245 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000014 ] ) ] . obo:OBI_0000451 obo:IAO_0000111 "normalized data set" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A data set that is produced as the output of a normalization data transformation."@en ; obo:IAO_0000117 "PERSON: James Malone", "PERSON: Melanie Courtot" ; a owl:Class ; rdfs:label "normalized data set"@en ; rdfs:subClassOf obo:IAO_0000100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0200169 ] . obo:OBI_0000453 obo:IAO_0000111 "measure function"@en ; obo:IAO_0000112 "A glucometer measures blood glucose concentration, the glucometer has a measure function." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "Measure function is a function that is borne by a processed material and realized in a process in which information about some entity is expressed relative to some reference."@en ; obo:IAO_0000117 "PERSON: Daniel Schober", "PERSON: Helen Parkinson", "PERSON: Melanie Courtot", "PERSON:Frank Gibson" ; a owl:Class ; rdfs:label "measure function"@en ; rdfs:subClassOf obo:BFO_0000034, [ a owl:Restriction ; owl:onProperty obo:RO_0000079 ; owl:someValuesFrom obo:OBI_0000047 ], [ a owl:Restriction ; owl:allValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ] ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000454 obo:IAO_0000111 "extracellular electrophysiology recording assay" ; obo:IAO_0000112 "The recording of a spike train in the caudate nucleus of a monkey where the electrodes are extra cellular, i.e. not in the neuron" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An electrophysiology assay where the recording location of the electrode is extracellular." ; obo:IAO_0000117 "Frank Gibson", "Helen Parkinson" ; obo:IAO_0000119 "Frank Gibson" ; a owl:Class ; rdfs:label "extracellular electrophysiology recording assay" ; rdfs:subClassOf obo:OBI_0002176, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000414 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0005216 ] ] . obo:OBI_0000455 obo:IAO_0000111 "consume data function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "Process data function is a function that is borne by in a material entity by virtue of its structure. When realized the material entity consumes data."@en ; obo:IAO_0000117 "PERSON: Daniel Schober", "PERSON: Frank Gibson", "PERSON: Melanie Courtot" ; a owl:Class ; rdfs:label "consume data function"@en ; rdfs:subClassOf obo:BFO_0000034, [ a owl:Restriction ; owl:onProperty obo:RO_0000079 ; owl:someValuesFrom obo:BFO_0000040 ] . obo:OBI_0000456 obo:IAO_0000111 "material transformation objective" ; obo:IAO_0000112 "The objective to create a mouse infected with LCM virus. The objective to create a defined solution of PBS." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "an objective specifiction that creates an specific output object from input materials."@en ; obo:IAO_0000117 "PERSON: Bjoern Peters", "PERSON: Frank Gibson", "PERSON: Jennifer Fostel", "PERSON: Melanie Courtot", "PERSON: Philippe Rocca-Serra" ; obo:IAO_0000118 "artifact creation objective"@en ; obo:IAO_0000119 "GROUP: OBI PlanAndPlannedProcess Branch" ; a owl:Class ; rdfs:label "material transformation objective"@en ; rdfs:subClassOf obo:IAO_0000005 . obo:OBI_0000457 obo:IAO_0000111 "manufacturing" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A planned process with the objective to produce a processed material which will have a function for future use."@en ; obo:IAO_0000116 "A person or organization (having manufacturer role) is a participant in this process", "Manufacturing implies reproducibility and responsibility AR", "This includes a single scientist making a processed material for personal use."@en ; obo:IAO_0000117 "PERSON: Bjoern Peters", "PERSON: Frank Gibson", "PERSON: Jennifer Fostel", "PERSON: Melanie Courtot", "PERSON: Philippe Rocca-Serra" ; obo:IAO_0000119 "GROUP: OBI PlanAndPlannedProcess Branch" ; a owl:Class ; rdfs:label "manufacturing"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:BFO_0000040 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000047 ] ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000458 ] . obo:OBI_0000458 obo:IAO_0000111 "manufacturing objective" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "is the objective to manufacture a material of a certain function (device)"@en ; obo:IAO_0000117 "PERSON: Bjoern Peters", "PERSON: Frank Gibson", "PERSON: Jennifer Fostel", "PERSON: Melanie Courtot", "PERSON: Philippe Rocca-Serra" ; obo:IAO_0000119 "GROUP: OBI PlanAndPlannedProcess Branch" ; a owl:Class ; rdfs:label "manufacturing objective"@en ; rdfs:subClassOf obo:OBI_0000456 . obo:OBI_0000459 obo:IAO_0000111 "is_specified_information_output_of" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A relation between a data set and the process in which it participates and was produced. Inverse of outputs_specified_data relation." ; obo:IAO_0000116 "is replaced by has_specified_output_of" ; obo:IAO_0000117 "PERSON: James Malone" ; obo:IAO_0000119 "Editor" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:ObjectProperty ; rdfs:label "obsoleted_is_specified_information_output_of" ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:OBI_0000461 obo:IAO_0000111 "obsolete_the supplier role of Affymetrix" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:NamedIndividual, owl:Thing ; rdfs:label "obsolete_the supplier role of Affymetrix" ; owl:deprecated true . obo:OBI_0000462 obo:IAO_0000111 "Affymetrix" ; obo:IAO_0000112 "Affymetrix supplied microarray" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An organization which supplies technology, tools and protocols for use in high throughput applications" ; a obo:OBI_0000835, obo:OBI_0002989, owl:NamedIndividual ; rdfs:label "Affymetrix" . obo:OBI_0000463 obo:IAO_0000111 "column chromatography detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "There is a wide range of detectors available for both GC and LC each having their own particular areas of application. In general the more catholic the response, the less sensitive the detector and the most sensitive detectors are those that have a specific response. The performance of all detectors should be properly specified so that the user can determine which is most suitable for a specific application. Such specifications are also essential to compare the performance of different detectors supplied by alternative instrument manufactures. Detector specifications should be presented in a standard form and in standard units, so that detectors can be compared that function on widely different principles." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01077" ; obo:IAO_0000232 "chromatography detector, defined class/xps" ; a owl:Class ; rdfs:label "column chromatography detector" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000464 obo:IAO_0000111 "Bruker autosampler" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Bruker autosampler is an autosampler made by Bruker." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400209" ; a owl:Class ; rdfs:label "Bruker autosampler" ; rdfs:subClassOf obo:OBI_0000555 . obo:OBI_0000465 obo:IAO_0000111 "organic acid column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organic acid column is a chromatography column which enables (reversed-phase) separation of hydrophilic aliphatic and aromatic organic acids with UV detection. Organic acid columns allow retention of polar and apolar organic acids and are hydrolysis resistant." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01099" ; a owl:Class ; rdfs:label "organic acid column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000466 obo:IAO_0000111 "thermal conductivity detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The most commonly used detector in preparative GC is the thermal conductivity detector (hot wire detector). Even this detector, however, is often too sensitive and has too high a flow impedance. Under such circumstances, the procedure mentioned above must be employed. The eluent from the preparative column is split and a small portion diverted through the detector (sometimes with further dilution with carrier gas to reduce sensitivity)." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "TCD, hot wire detector" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01084" ; a owl:Class ; rdfs:label "thermal conductivity detector" ; rdfs:subClassOf obo:OBI_0000637 . obo:OBI_0000467 obo:IAO_0000111 "Bruker US 2 NMR magnet" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An actively-shielded superconducting magnet from Bruker that combines Bruker BioSpin's advanced, proprietary UltraShield active shielding and UltraStabilized sub-cooling technologies. This shielded and stabilized (US2) magnet system delivers high sensitivity and spectral dispersion." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400189" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Bruker US 2 NMR magnet" ; rdfs:subClassOf obo:OBI_0000597 . obo:OBI_0000468 obo:IAO_0000111 "protein column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A protein column is a chromatography column used for the separation of complex protein mixtures. Protein columns enable sample desalting, followed by chromatographic separation or fractionation of complex protein samples, e.g. immunodepleted serum or plasma proteins." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01238" ; obo:IAO_0000232 "refactor as defined class" ; a owl:Class ; rdfs:label "protein column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000469 obo:IAO_0000111 "solvent mixer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A liquid chromatography device that mixes different solvents, e.g. under high pressure and in differrent volumes ranging from 5 ml to 5 L capacity. Powerful magnetic mixers provide vigorous agitation required for high pressure reaction chemistry." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01072" ; a owl:Class ; rdfs:label "solvent mixer" ; rdfs:subClassOf obo:OBI_0000485 . obo:OBI_0000470 obo:IAO_0000111 "mass spectrometry assay" ; obo:IAO_0000112 "Identification of a proteins cut out from a 2D gel by cleaving it into peptides using trypsin digestion using electrospray ionizatino to ensure the peptides are charged, and accelerating them with an electro magnetic field in which the flight path is determined by the mass / charge ratio of the peptides. Comparing the mass/charge ratio of peptides in the proteins with databases of protein sequences allows to identify which protein gave rise to the peptides." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that identifies the amount and type of material entities present in a sample by fragmenting the sample and measuring the mass-to-charge ratio of the resulting particles." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "Philippe Rocca-Serra" ; a owl:Class ; rdfs:label "mass spectrometry assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000049 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000049 ] ) ] ) ] . obo:OBI_0000471 obo:IAO_0000111 "study design execution" ; obo:IAO_0000112 "injecting a mouse with PBS solution, weighing it, and recording the weight according to a study design." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "a planned process that carries out a study design" ; obo:IAO_0000116 "removed axiom has_part some (assay or 'data transformation') per discussion on protocol application mailing list to improve reasoner performance. The axiom is still desired." ; obo:IAO_0000119 "branch derived" ; obo:IAO_0000232 "6/11/9: edited at workshop. Used to be: study design execution is a process with the objective to generate data according to a concretized study design. The execution of a study design is part of an investigation, and minimally consists of an assay or data transformation." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "study design execution" ; rdfs:subClassOf obo:OBI_0000011 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000011 [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000059 ; owl:someValuesFrom obo:OBI_0500000 ] ] ) ] . obo:OBI_0000473 obo:IAO_0000111 "Bruker NMR Case sample changer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The NMR Case is an economical NMR sample changer for laboratories with modest automation needs. It expands the maximum number of samples your spectrometer can process during unattended operation to 24. The NMR Case consists of multiple components. The NMR Case exchange module installed atop your cryostat. The two front legs are adjustable, making the NMR Case compatible with many different cryostats." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400203" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Bruker NMR Case sample changer" ; rdfs:subClassOf obo:OBI_0000464 . obo:OBI_0000474 obo:IAO_0000111 "nano pump system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pump system optimized for nano flow chromatography." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01052" ; a owl:Class ; rdfs:label "nano pump system" ; rdfs:subClassOf obo:OBI_0000589 . obo:OBI_0000475 obo:IAO_0000111 "Bruker AutoClean system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "NMR tubes are often used once and discarded, creating needless waste. With the Bruker BioSpin Autoclean system you can now recycle 5mm, 3mm, or 5mm/3mm step-down (Wilmad 520-1B) NMR tubes. AutoClean NMR Tube Washing System is a simple way to recoup the substantial investment your organization makes in quality NMR tubes, and cut back on needless waste material." ; obo:IAO_0000116 "washing system/NMR tube washing system, XPS: device has function washing" ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400205" ; a owl:Class ; rdfs:label "Bruker AutoClean system" ; rdfs:subClassOf obo:OBI_0000498 . obo:OBI_0000476 obo:IAO_0000111 "manual injection system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The traditional hardware system that allows a human to inject a sample into an inlet by hand, using a syringe." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01064" ; a owl:Class ; rdfs:label "manual injection system" ; rdfs:subClassOf obo:OBI_0000504 . obo:OBI_0000477 obo:IAO_0000111 "Varian GEMINI spectrometer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An older Varian Broadband NMR spectrometer." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400239" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Varian GEMINI spectrometer" ; rdfs:subClassOf obo:OBI_0000611 . obo:OBI_0000478 obo:IAO_0000111 "column connector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that connects two or more columns together in a functional way with leak-tight connection, low dead volume, low thermal mass and high inertness." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01236" ; obo:IAO_0000232 "chromatography device" ; a owl:Class ; rdfs:label "column connector" ; rdfs:subClassOf obo:OBI_0000048 . obo:OBI_0000479 obo:IAO_0000111 "solid NMR probe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR probe that is designed to hold a solid sample." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400243" ; obo:IAO_0000232 "NMR device" ; a owl:Class ; rdfs:label "solid NMR probe" ; rdfs:subClassOf obo:OBI_0000516 . obo:OBI_0000480 obo:IAO_0000111 "Bruker high resolution probe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "BRUKER BIOSPIN's experienced Research & Development group not only delivers top-performance probes for the more common experiments, but also a wealth of special probes for almost any application. For high resolution (HR) NMR we offer probes with a variety of important characteristics and features." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "HR Probe" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400223" ; obo:IAO_0000232 "NMR probe" ; a owl:Class ; rdfs:label "Bruker high resolution probe" ; rdfs:subClassOf obo:OBI_0000561 . obo:OBI_0000481 obo:IAO_0000111 "chromatography detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A chromatography detector is a device that locates in the dimensions of space and time, the positions of the components of a mixture that has been subjected to a chromatographic process and thus permits the senses to appreciate the nature of the separation. Defining characteristics are Dynamic Range, Response Index or Linearity, Linear Dynamic range, Detector Response, Detector Noise Level, Detector Sensitivity or Minimum Detectable Concentration, Total System Dispersion, Sensor Dimensions, Detector Time Constant, Pressure Sensitivity, Flow Sensitivity, Operating Temperature Range." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01012" ; a owl:Class ; rdfs:label "chromatography detector" ; rdfs:subClassOf obo:OBI_0000485 . obo:OBI_0000482 obo:IAO_0000111 "normal phase column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A normal phase column is a chromatography column in which the stationary phase is more polar than the mobile phase. Its counterpart is the reversed phase column." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01097" ; a owl:Class ; rdfs:label "normal phase column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000483 obo:IAO_0000111 "APOLLO console" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The APOLLO is a compact, modular, multiple-DSP, Windows XP Professional-based console that can be equipped with up to 8 DDS-based RF transmitter channels configurable from 2 kHz to 3.5 GHz. Each transmitter channel produces a nominal 1V output and has the most agile frequency, phase and amplitude control of any system on the market. An array of additional options are available including multiple RF transmitters, linear high-power RF amplifiers, digital receiver arrays, low noise figure preamplifiers, a gradient control system, shim unit, MAS spin-speed controller, variable temperature unit, digital lock system and probe/coil interface. With its numerous options, the Apollo can be configured for any NMR, NQR or MRI application." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400249" ; obo:IAO_0000232 "NMR instrument/NMR console" ; a owl:Class ; rdfs:label "APOLLO console" ; rdfs:subClassOf obo:OBI_0000599 . obo:OBI_0000484 obo:IAO_0000111 "NMR sample holder" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR sample holder is the part of an NMR instrument, which carries the NMR probe,sample tube and the nmr sample." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400212" ; obo:IAO_0000232 "NMR device" ; a owl:Class ; rdfs:label "NMR sample holder" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0000485 obo:IAO_0000111 "chromatography instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Any instrument that is used to carry out a chromatography experiment." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01262" ; obo:IAO_0000232 "chromatography device, defined class?" ; a owl:Class ; rdfs:label "chromatography instrument" ; rdfs:subClassOf obo:OBI_0000932, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000372 ] . obo:OBI_0000486 obo:IAO_0000111 "continuous wave NMR instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Continuous wave NMR spectrometers are similar to optical spectrometers, but the sample is held in a strong magnetic field, where the frequency of the source is slowly scanned (in some instruments, the source frequency is held constant, and the field is scanned)." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400283" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "continuous wave NMR instrument" ; rdfs:subClassOf obo:OBI_0000566 . obo:OBI_0000487 obo:IAO_0000111 "fourier transformation NMR instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "In fourier transformation NMR, all frequencies in a spectrum are irradiated simultaneously with a radio frequency pulse. Following the pulse, the nuclei return to thermal equilibrium. A time domain emission signal is recorded by the instrument as the nuclei relax. A frequency domain spectrum is obtained by Fourier transformation." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400284" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "fourier transformation NMR instrument" ; rdfs:subClassOf obo:OBI_0000566 . obo:OBI_0000489 obo:IAO_0000111 "nitrogen phosphorous detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The nitrogen phosphorus detector (NPD) (sometimes called the thermionic detector) is a very sensitive, specific detector the design of which, is based on the FID. Physically the sensor appears to be very similar to the FID but, in fact, operates on an entirely different principle. The nitrogen phosphorous detector (sometimes called the thermionic detector) is a very sensitive but specific detector that responds almost exclusively to nitrogen and phosphorous compounds. It is based on the flame ionization detector but differs in that it contains a rubidium or cesium silicate (glass) bead situated in a heater coil, a little distance from the hydrogen flame. If the detector is to respond to both nitrogen and phosphorous then the hydrogen flow should be minimal so that the gas does not ignite at the jet. If the detector is to respond to phosphorous only, a large flow of hydrogen is used which is burnt at the jet. The heated bead emits electrons by thermionic emission. These electrons are collected under a potential of a few volts by an appropriately placed anode, and provides a background current. When a solute containing nitrogen or phosphorous is eluted from the column, the partially combusted nitrogen and phosphorous materials are adsorbed on the surface of the bead. The adsorbed material reduces the work function of the surface and, as consequence, the emission of electrons is increased which raises the current collected at the electrode. The sensitivity of the detector to phosphorous is about 10-12 gram per ml and for nitrogen about 10-11 gram per ml at a signal to nose ratio of 2. The alkali bead as a finite life and needs regular replacement." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01089" ; a owl:Class ; rdfs:label "nitrogen phosphorous detector" ; rdfs:subClassOf obo:OBI_0000637 . obo:OBI_0000490 obo:IAO_0000111 "cation exchange column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cation exchange column is a chromatography column that is used in cation exchange chromatography." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01096" ; a owl:Class ; rdfs:label "cation exchange column" ; rdfs:subClassOf obo:OBI_0000560 . obo:OBI_0000491 obo:IAO_0000111 "direct detection NMR probe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR probe designed to allow the direct detection of acquisition nuclei." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400280" ; obo:IAO_0000232 "NMR device" ; a owl:Class ; rdfs:label "direct detection NMR probe" ; rdfs:subClassOf obo:OBI_0000516 . obo:OBI_0000492 obo:IAO_0000111 "Bruker B-ACS system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The Bruker Automatic Sample Changer (B-ACS 60/120), used in conjunction with Bruker DISNMR, UXNMR or XWIN-NMR software, provides dialog-guided facilities which allow the user to easily and effectively perform automatic (continuous) experiments. Features include a 60 or 120 sample capacity, random accessing of samples, positive sample identification with the optional bar code reader, and temperature control of individual samples with the optional sample heater unit." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400210" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Bruker B-ACS system" ; rdfs:subClassOf obo:OBI_0000464 . obo:OBI_0000493 obo:IAO_0000111 "rapid resolution column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A rapid resolution column is a chromatography column as marketed by Agilent, which is used with a rapid resolution cartridge to ensure a fast chromatography process with good separation resolution." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01102" ; a owl:Class ; rdfs:label "rapid resolution column" ; rdfs:subClassOf obo:OBI_0000932, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000372 ] . obo:OBI_0000494 obo:IAO_0000111 "liquid chromatography autosampler" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Designed to perform capillary LC with injection of sample volumes ranging from nL to L." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01061" ; a owl:Class ; rdfs:label "liquid chromatography autosampler" ; rdfs:subClassOf obo:OBI_0000485 . obo:OBI_0000495 obo:IAO_0000111 "vacuum degasser" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A degassing system used for degassing solvents in liquid chromatography. Dissolved gasses, usually nitrogen and oxygen from the air, tend to be evolved in the mobile phase as the pressure is reduced when the mobile phase leaves the liquid chromatography column and enters the detector. Gasses in the mobile phase in the detector can produce completely unacceptable noise and, thus, must be removed. The dissolved gasses were originally removed under vacuum but, unfortunately, are soon replaced if the solvent is left in contact with air at atmospheric pressure. For this reason degassing is now usually carried out by bubbling helium through the mobile phase reservoirs. Secondly, vacuum is used in the thermionic detector. This consists of a device, very similar in design to the thermionic valve which is attached to a vacuum and a small quantity of the eluent from a gas chromatography column allowed to bleed through it. Helium is used as the carrier gas. The presence of solute vapor causes the thermionic current to fall. This type of detector tends to become contaminated rather readily." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01053" ; a owl:Class ; rdfs:label "vacuum degasser" ; rdfs:subClassOf obo:OBI_0000589 . obo:OBI_0000496 obo:IAO_0000111 "capillary column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A capillary column is a thin tube with a small inner diameter, usually around 0.5 mm." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01066" ; a owl:Class ; rdfs:label "capillary column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000497 obo:IAO_0000111 "sample inlet" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The column inlet (or injector) provides the means to introduce a sample into a continuous flow of carrier gas. The inlet is a piece of hardware attached to the column head." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01044" ; obo:IAO_0000232 "chromatography device" ; a owl:Class ; rdfs:label "sample inlet" ; rdfs:subClassOf obo:OBI_0000048 . obo:OBI_0000498 obo:IAO_0000111 "NMR tube washing system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An automatic cleaning system for NMR tubes that removes previous probe and sample residues in order to allow for tube recycling." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400204" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "NMR tube washing system" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0000499 obo:IAO_0000111 "NMR console" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A component of an NMR instrument that controls the activities of the other components." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400015" ; obo:IAO_0000232 "NMR instrument, TODO: same as or part of acquisition computer?" ; a owl:Class ; rdfs:label "NMR console" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0000500 obo:IAO_0000111 "dual loop autosampler" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A dual loop autosampler is an autosampler that is designed for handling both analytical (10 mL/min flow rate) to preparative scale sample purification (100 mL/min flow rate)." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01063" ; a owl:Class ; rdfs:label "dual loop autosampler" ; rdfs:subClassOf obo:OBI_0000494 . obo:OBI_0000501 obo:IAO_0000111 "variable wavelength detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A chromatography detector, that can detect signals within a certain range at user-defined wavelengths." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01079" ; a owl:Class ; rdfs:label "variable wavelength detector" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000503 obo:IAO_0000111 "Bruker LC-NMR platform" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The LC-NMR/MS setup was first introduced by Bruker BioSpin in 1999. An LC-NMR system including a Bruker Peak Sampling Unit (BPSU-36) was coupled with a Bruker Daltonics esquire series ion trap mass spectrometer via a Bruker NMR-MS interface (BNMI). Since October 2004 the Bruker Daltonics microTOF-LC time-of-flight mass spectrometer can also be integrated in an LC-NMR setup." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400276" ; obo:IAO_0000232 "NMR instrument", "hyphenated NMR instrument platform" ; a owl:Class ; rdfs:label "Bruker LC-NMR platform" ; rdfs:subClassOf obo:OBI_0000596 . obo:OBI_0000504 obo:IAO_0000111 "sample injection system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An automated chromatography system that injects the sample into the chromatography columns in order to increase speed and minimize human involvement in the purification process for better reproducibility." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01057" ; obo:IAO_0000232 "chromatography device" ; a owl:Class ; rdfs:label "sample injection system" ; rdfs:subClassOf obo:OBI_0000048 . obo:OBI_0000505 obo:IAO_0000111 "multiple wavelength detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A chromatography detector, that can detect many discrete wavelengths in parallel and produces a multiple wavelength chromatographic profile." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01078" ; a owl:Class ; rdfs:label "multiple wavelength detector" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000506 obo:IAO_0000111 "photoionization detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The selective determination of aromatic hydrocarbons or organo-heteroatom species is the job of the photoionization detector (PID). This device uses ultraviolet light as a means of ionizing an analyte exiting from a GC column. The ions produced by this process are collected by electrodes. The current generated is therefore a measure of the analyte concentration. f the amount of ionization is reproducible for a given compound, pressure, and light source then the current collected at the PID's reaction cell electrodes is reproducibly proportional to the amount of that compound entering the cell. The reason why the compounds that are routinely analyzed are either aromatic hydrocarbons or heteroatom containing compounds (like organosulfur or organophosphorus species) is because these species have ionization potentials (IP) that are within reach of commercially available UV lamps. The available lamp energies range from 8.3 to 11.7 ev, that is, lambda max ranging from 150 nm to 106 nm. Although most PIDs have only one lamp, lamps in the PID are exchanged depending on the compound selectivity required in the analysis." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "PID" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01090" ; a owl:Class ; rdfs:label "photoionization detector" ; rdfs:subClassOf obo:OBI_0000637 . obo:OBI_0000507 obo:IAO_0000111 "gas generator" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An instrument that generates gases for use with the gas chromatograph. Previously gas was obtained from gas tanks or gas cylinders. However, over the past decade the use of gas generators have become more popular as it avoids having gases at high pressure in the laboratory which is perceived by some as potentially dangerous. In addition, the use of a hydrogen generator avoids the use of a cylinder of hydrogen at high pressure which is also perceived by some as a serious fire hazard despite the fact that they have been used in laboratories, quite safely for nearly a century." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01033" ; obo:IAO_0000232 "gas chromatography equipment" ; a owl:Class ; rdfs:label "gas generator" ; rdfs:subClassOf obo:OBI_0000542 . obo:OBI_0000508 obo:IAO_0000111 "column jacket" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A column jacket is a piece of column chromatography equipment that covers a column in order to ensure thermoisolation and create a controllable thermostatic microenvironment." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01276" ; obo:IAO_0000232 "chromatography device" ; a owl:Class ; rdfs:label "column jacket" ; rdfs:subClassOf obo:OBI_0000048 . obo:OBI_0000509 obo:IAO_0000111 "electron capture detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The electron capture detector is a GC detector that uses a radioactive Beta emitter (electrons) to ionize some of the carrier gas and produce a current between a biased pair of electrodes. When organic molecules that contain electronegative functional groups, such as halogens, phosphorous, and nitro groups pass by the detector, they capture some of the electrons and reduce the current measured between the electrodes." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "ECD" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01085" ; a owl:Class ; rdfs:label "electron capture detector" ; rdfs:subClassOf obo:OBI_0000637 . obo:OBI_0000510 obo:IAO_0000111 "reversed phase column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A reversed phase column is a chromatography column in which the mobile phase is more polar than the stationary phase. Its counterpart is the normal phase column." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01106" ; a owl:Class ; rdfs:label "reversed phase column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000511 obo:IAO_0000111 "injector lubricant" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A lubricant used in liquid chromatography that eases sample injector penetration." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01118" ; a owl:Class ; rdfs:label "injector lubricant" ; rdfs:subClassOf obo:OBI_0000601 . obo:OBI_0000512 obo:IAO_0000111 "isolation of cell population" ; obo:IAO_0000112 "removing CD4+ cells from PBMCs using magnetic beads." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a process in which a population of cells with certain characteristics is isolated from a larger population" ; obo:IAO_0000117 "Person: Bjoern Peters" ; a owl:Class ; rdfs:label "isolation of cell population" ; rdfs:subClassOf obo:OBI_0600014, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100060 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0100060 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000681 ] . obo:OBI_0000513 obo:IAO_0000111 "DISCOVERY console" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The Discovery console is a Windows XP Professional-based, integrated console designed especially for Solid-State NMR. The console includes everything needed to interface to any magnet and solids probe - from computer to cables to duplexing network." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400247" ; obo:IAO_0000232 "NMR instrument/NMR console" ; a owl:Class ; rdfs:label "DISCOVERY console" ; rdfs:subClassOf obo:OBI_0000599 . obo:OBI_0000514 obo:IAO_0000111 "Bruker AMX series NMR instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A series of older Bruker NMR magnets, now out of production. The Bruker AMX500 has proven an extremely reliable workhorse, with excellent lineshape yielding superior water suppression even without gradients. The Oxford 11.7 Tesla 5.2 cm bore magnet rests on a TMC vibration damping table. Homogeneity is controlled by a BSN-18 and BSN-2 with 19 shim controls. In addition to the 5 mm triple resonance probe, the AMX is equipped with a 10mm broadband observe probe." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400240" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Bruker AMX series NMR instrument" ; rdfs:subClassOf obo:OBI_0000596 . obo:OBI_0000515 obo:IAO_0000111 "chromatofocusing column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A chromatofocusing column is a chromatography column in which a resin is equilibrated at one pH and eluted at a second pH. The use of a weak ion-exchange resin causes a pH gradient to be formed at the solvent front owing to the buffering action of the resin. This pH gradient in turn leads to an ordering of proteins by isoelectric point. Molecules of charge sign opposite the resin bind; those of charge sign like the resin do not bind." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01209" ; a owl:Class ; rdfs:label "chromatofocusing column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000516 obo:IAO_0000111 "NMR probe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Part of an NMR instrument that detects the signals emitted from a sample. No single probe can perform the full range of experiments, and probes that are designed to perform more than one type of measurement usually suffer from performance compromises. The probe represents a rather fragile single point of failure that can render an NMR system completely unusable if the probe is dropped or otherwise damaged. Probes are usually characterised by Sample diameter and Frequency.n alt The instrument that transmits and receives radiofrequency to and from the NMR sample." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400014" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "NMR probe" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0000566 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000517 obo:IAO_0000111 "NMR magnet" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A magnet which induces a certain frequency (MHz) and which has a certain bore diameter.n alt The NMR signal is a natural physical property of the certain atomic nuclei but it can only be detected with an external magnetic field. A magnet is a fundamental part of an NMR instrument which induces an electromagnetic force field (RF pulse) and by this excites and aligns the spins of the electrons of the NMR acquisition nucleus. It is usually a big (superconducting) electromagnet which is cooled by liquid helium and can be adjusted to a frequency between 200 and 950 MHz. The magnetic field strength is measured in Tesla or Gauss." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400185" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "NMR magnet" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0000518 obo:IAO_0000111 "trap column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A trap column is a chromatography column which is used prior to a, e.g. mass spectrometry, separation to clean up or concentrate controlled amounts of samples prior to elution to a detector." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01261" ; a owl:Class ; rdfs:label "trap column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000519 obo:IAO_0000111 "flow probe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR probe that allows the automatized flow-through of a sample. The sample is aspirated via a syringe pump into the Flow probe, the NMR spectrum is acquired and when the experiment is complete, the sample is returned to back to an external source (well plate) or flushed to waste. Sometimes pulsed field gradients (PFG) can be established in flow probes." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400131" ; obo:IAO_0000232 "NMR device" ; a owl:Class ; rdfs:label "flow probe" ; rdfs:subClassOf obo:OBI_0000516 . obo:OBI_0000520 obo:IAO_0000111 "clinical chemistry assay" ; obo:IAO_0000112 "Influence of hydroxyethyl starch (6% HES 130/0.4) administration on hematology and clinical chemistry parameters." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay which uses analytical methods to produce measurements and data on the concentration of chemical parameters (analytes) present in a bodily fluid collected from an organism." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "chemical pathology", "detection of analyte in blood sample" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Clinical_chemistry" ; a owl:Class ; rdfs:label "clinical chemistry assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000009 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000009 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000576 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000576 ] ) ] . obo:OBI_0000521 obo:IAO_0000111 "flame ionization detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flame ionization detector is a GC detector that consist of a hydrogen/air flame and a collector plate which are normally heated independently of the chromatographic oven. Heating is necessary in order to prevent condensation of water generated by the flame and also to prevent any hold-up of solutes as they pass from the column to the flame. There is an electrode above the flame to collect the ions formed at a hydrogen/air flame. The number of ions hitting the collector is measured and a signal is generated. Flame ionization detectors are most widely used and generally applicable for gas chromatography and hence is used for routine and general purpose analysis. It is easy to use but destructive of the sample." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "FID" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01197" ; a owl:Class ; rdfs:label "flame ionization detector" ; rdfs:subClassOf obo:OBI_0000637 . obo:OBI_0000522 obo:IAO_0000111 "vial" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A container made from solid material and primarily used for holding liquid." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Vial" ; a owl:Class ; rdfs:label "vial" ; rdfs:subClassOf obo:OBI_0000967 . obo:OBI_0000523 obo:IAO_0000111 "magic angle spinning rotor" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A rotor device that holds the NMR sample and enables the adjustment of the orientation of the rotation axis for a sample in a NMR instrument in the magic angle." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "MAS rotor" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400130" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "magic angle spinning rotor" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0000566 ] . obo:OBI_0000524 obo:IAO_0000111 "Varian VXR spectrometer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Varian NMR spectrometer." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400238" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Varian VXR spectrometer" ; rdfs:subClassOf obo:OBI_0000611 . obo:OBI_0000525 obo:IAO_0000111 "splitless GC injector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Injected sample enters column immediately (while split valve to split vent is closed). Here a sample is introduced into a heated small chamber via a syringe through a septum - the heat facilitates volatilization of the sample and sample matrix. The carrier gas then either sweeps the entirety (splitless mode) or a portion (split mode) of the sample into the column. In split mode, a part of the sample/carrier gas mixture in the injection chamber is exhausted through the split vent." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01060" ; a owl:Class ; rdfs:label "splitless GC injector" ; rdfs:subClassOf obo:OBI_0000504 . obo:OBI_0000526 obo:IAO_0000111 "preparative autosampler" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "For preparative LC with injection of sample volumes ranging from L to mL ranges." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01062" ; a owl:Class ; rdfs:label "preparative autosampler" ; rdfs:subClassOf obo:OBI_0000494 . obo:OBI_0000527 obo:IAO_0000111 "flow high resolution probe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Hyphenated analytical techniques combining mass spectrometry and chromatography are well-established laboratory tools. The combination of chromatography and NMR has also made its way into the analytical laboratory. Further developments even combine all three techniques into an LC-NMR/NMR-MS system. The use of solid phase extraction provides an efficient interface between chromatography and NMR with demands for special type of flow probes." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "flow HR-probe" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400195" ; obo:IAO_0000232 "NMR probe" ; a owl:Class ; rdfs:label "flow high resolution probe" ; rdfs:subClassOf obo:OBI_0000480 . obo:OBI_0000528 obo:IAO_0000111 "liquid chromatography valve" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A sample valve that must be able to sustain pressures up to 10,000 p.s.i., although it is most likely to operate on a continuous basis, at pressures of 3,000 p.s.i. or less. The higher the operating pressure the tighter the valve seating surfaces must be forced together to eliminate any leak. It follows that any abrasive material, however fine, that passes into the valve can cause the valve seating to become scored each time it is rotated which will ultimately lead to leaks. This will cause the sample size to vary between samples and eventually affect the accuracy of the analysis. It follows that any solid material must be carefully removed from any sample before filling the valve. The sample volume of an internal loop valve is situated in the connecting slot of the valve rotor and can be used only for relatively small sample volumes. Internal sample loop valves provide samples with volumes ranging from 0.1 ml to about 0.5 ml. Valve operation is shown in figure 6. The left-hand side diagram shows the load position. The sample occupies the rotor slot and has been filled by passing the sample from an appropriate syringe through the rotor slot to waste. While loading the sample, the mobile phase supply is passed through the valve directly to the column. To place the sample onto the column, the valve is then rotated and the valve slot containing the sample is now placed between the solvent supply and the column. As a result, the sample is passed into the column by the flow of solvent." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01110" ; obo:IAO_0000232 "chromatography device" ; a owl:Class ; rdfs:label "liquid chromatography valve" ; rdfs:subClassOf obo:OBI_0000048 . obo:OBI_0000529 obo:IAO_0000111 "JEOL NMR probe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR probe that is manufactured by JEOL." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400232" ; obo:IAO_0000232 "NMR device" ; a owl:Class ; rdfs:label "JEOL NMR probe" ; rdfs:subClassOf obo:OBI_0000516 . obo:OBI_0000530 obo:IAO_0000111 "Bruker UltraShield Plus NMR magnet" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR magnet of which Brukers claims it is the latest and most advanced self-shielding NMR magnet technology ever developed. These magnets are the ultimate advancement in high performance, actively-shielded NMR solutions. They offer unprecedented shielding performance whilst ensuring no compromise in system homogeneity, stability or cryogenic specifications." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400190" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Bruker UltraShield Plus NMR magnet" ; rdfs:subClassOf obo:OBI_0000597 . obo:OBI_0000531 obo:IAO_0000111 "Bruker CryoProbe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The Bruker BioSpin CryoProbe is a high-performance cryogenically cooled probe developed for high-resolution applications. It has improved signal/noise (S/N) ratios obtained by reducing the operating temperature of the coil and the pre-amplifier. As a result, the efficiency of the coil is improved and the noise of the coil and the pre-amplifier are reduced.The dramatic increase in the S/N ratio by a factor of 3-4, as compared to conventional probes, leads to a possible reduction in experiment time of up to 16 or a reduction in required sample concentration by a factor of up to 4. The CryoProbes possess key characteristics for NMR analysis:n Significant S/N gains (with moderately salty samples also)n Short pulse widthsn Short ring down timesn Linear behavior in power responsen Gradient capabilityn CryoProbes are available as Triple Resonance, Dual, Selective X Detection, MicroImaging, and Quad Nucleus Probes configurations at 400 MHz and highern All high resolution probes have a lock circuitn All high resolution probes have Z-gradient." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400191" ; obo:IAO_0000232 "NMR probe" ; a owl:Class ; rdfs:label "Bruker CryoProbe" ; rdfs:subClassOf obo:OBI_0000561 . obo:OBI_0000532 obo:IAO_0000111 "column cartridge" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that binds the chromatography column and additional connector elements and / or valves or syringes into one physical unity for further processing." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01055" ; a owl:Class ; rdfs:label "column cartridge" ; rdfs:subClassOf obo:OBI_0000048 . obo:OBI_0000533 obo:IAO_0000111 "affinity column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An affinity column is a chromatography column that is used in affinity chromatography. Differences in the affinity of molecules to be separated to a stationary phase are used for discriminate retention." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01094" ; a owl:Class ; rdfs:label "affinity column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000534 obo:IAO_0000111 "tecmag NMR instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR instrument that is manufactured by tecmag." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400250" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "tecmag NMR instrument" ; rdfs:subClassOf obo:OBI_0000566 . obo:OBI_0000535 obo:IAO_0000111 "gel filtration column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Gel filtration column is a chromatography column for size-exclusion chromatography, in which the stationary phase is a gel. The main application of gel filtration chromatography is the fractionation of proteins and other water-soluble polymers." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01104" ; a owl:Class ; rdfs:label "gel filtration column" ; rdfs:subClassOf obo:OBI_0000618 . obo:OBI_0000536 obo:IAO_0000111 "fraction collector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A fraction detector is a device that allows regular or specified samples to be taken from a column eluate and stored in a retrievable form. The storage vessels are usually small sample tubes or vials that are oriented in a rotating disk or in a moving belt, there movement usually being controlled by a microprocessor. On receiving a signal from the microprocessor, the next vial is placed under the column outlet and the eluate collected until receiving another signal from the computer. Once the properties of the chromatogram that describes the separation has been ascertained, then the collection program can be defined. The fractions can be collected on a basis of time either at regular intervals or a specific times to collect specific peaks. Alternatively the fractions can be collected by monitoring the detector output and when a peak starts to elute the fraction collector is activated and the peak collected in a specific vial. When the peak returns to base line the column eluate is then directed to waste until the next peak starts eluting. Fraction collectors are in common use with most liquid chromatographs. They are used to collect samples for further purification, subsequent examination by spectroscopic techniques or for biological or organoleptic testing." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01073" ; a owl:Class ; rdfs:label "fraction collector" ; rdfs:subClassOf obo:OBI_0000485 . obo:OBI_0000537 obo:IAO_0000111 "copy number variation profiling assay" ; obo:IAO_0000112 "Profiling of copy number variations (CNVs) in healthy individuals from three ethnic groups using a human genome 32 K BAC-clone-based array. PMID:18058796" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that determines lost or amplified genomic regions of DNA by comparing genomic DNA originating from tissues from the same or different individuals using specific techniques such as CGH, array CGH, SNP genotyping" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "CNV analysis" ; a owl:Class ; rdfs:label "copy number variation profiling assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001404 ] ] . obo:OBI_0000538 obo:IAO_0000111 "in-line filter" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A solvent filter that sits between the pump and the injection valve that prevents dust particles, general debris and, to some extent, bacteria from entering the chromatography system. Contaminants can interfere with the low-pressure gradient former or the pump and particles entering valves may interfere with the proper function. The result could cause an increased baseline noise, non-repeatable gradient forming, unreliable flow rate or other interferences. Solvent in-line filters are low-pressure filters and will allow a high flow rate due to a large surface area and large porosity." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01123" ; a owl:Class ; rdfs:label "in-line filter" ; rdfs:subClassOf obo:OBI_0000592 . obo:OBI_0000539 obo:IAO_0000111 "imaging NMR probe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR probe that is designed for generating pictures from sample states via NMR imaging." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400244" ; obo:IAO_0000232 "NMR device" ; a owl:Class ; rdfs:label "imaging NMR probe" ; rdfs:subClassOf obo:OBI_0000516 . obo:OBI_0000540 obo:IAO_0000111 "isolation of adherent cells" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a material separation process in which cells that stick to the container in which they are grown as a cell culture are separated from those in the liquid component of the culture. The output of this process are adherent cells." ; a owl:Class ; rdfs:label "isolation of adherent cells" ; rdfs:subClassOf obo:OBI_0000512, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100060 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0100060 ] . obo:OBI_0000541 obo:IAO_0000111 "Bruker AC series NMR instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A series of older Bruker NMR magnets, now out of production." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400241" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Bruker AC series NMR instrument" ; rdfs:subClassOf obo:OBI_0000596 . obo:OBI_0000542 obo:IAO_0000111 "gas chromatography equipment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Any device used in a gas chromatography experiment." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01030" ; obo:IAO_0000232 "will become defined class/xps" ; a owl:Class ; rdfs:label "gas chromatography equipment" ; rdfs:subClassOf obo:OBI_0000048 . obo:OBI_0000543 obo:IAO_0000111 "syringe filter" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A small membrane filter of defined pore size, that filters samples from a syringe." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01122" ; a owl:Class ; rdfs:label "syringe filter" ; rdfs:subClassOf obo:OBI_0000592 . obo:OBI_0000544 obo:IAO_0000111 "Bruker SampleRail system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "This Instrument system automatically prepares an NMR sample, inserts it into an NMR magnet, performs NMR experiments on the sample, and transports it back to the preparation system. The SampleRail fulfills the transporting tasks from the preparation system into the NMR magnet and back." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400207" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Bruker SampleRail system" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000383 ] . obo:OBI_0000545 obo:IAO_0000111 "column compartment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "For chromatography analyses, the ability to maintain a stable column environment regardless of ambient temperature fluctuations is critical for maintaining retention time precision. In order to ensure such stable conditions at different chromatography steps a column compartment can be installed that ensures e.g. stable temperature of the column in a given step." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01068" ; a owl:Class ; rdfs:label "column compartment" ; rdfs:subClassOf obo:OBI_0000048 . obo:OBI_0000546 obo:IAO_0000111 "capillary pump system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pump system optimized for capillary chromatography." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01051" ; a owl:Class ; rdfs:label "capillary pump system" ; rdfs:subClassOf obo:OBI_0000589 . obo:OBI_0000547 obo:IAO_0000111 "evaporative light scattering detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The evaporative light scattering detector, as its name implies, utilizes a spray that continuously atomizes the column eluent into small droplets. These droplets are allowed to evaporate, leaving the solutes as fine particulate matter suspended in the atomizing gas." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01082" ; a owl:Class ; rdfs:label "evaporative light scattering detector" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000548 obo:IAO_0000111 "isolation of PBMCs" ; obo:IAO_0000112 "cells are extracted from whole blood using ficoll, a hydrophilic polysaccharide that separates layers of blood, with monocytes and lymphocytes forming a buffy coat under a layer of plasma. This buffy coat contains the PBMCs." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a process in which cells with a single nucleus are isolated from a blood sample" ; obo:IAO_0000117 "PERSON: bjoern peters" ; obo:IAO_0000119 "wiki http://en.wikipedia.org/wiki/PBMC" ; a owl:Class ; rdfs:label "isolation of PBMCs" ; rdfs:subClassOf obo:OBI_0000512, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0000178 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0100060 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000681 ] . obo:OBI_0000549 obo:IAO_0000111 "column cartridger" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A chromatography device where the column cartridge is inserted into and stabilised." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01054" ; a owl:Class ; rdfs:label "column cartridger" ; rdfs:subClassOf obo:OBI_0000485 . obo:OBI_0000550 obo:IAO_0000111 "nitrogen generator" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A gas generator that generates nitrogen gas." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01034" ; a owl:Class ; rdfs:label "nitrogen generator" ; rdfs:subClassOf obo:OBI_0000507 . obo:OBI_0000551 obo:IAO_0000111 "needle assembly" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The needle assembly attached to the autosampler, comprises the injector needle that feeds a sample or carrier gas into the inlet" ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01065" ; a owl:Class ; rdfs:label "needle assembly" ; rdfs:subClassOf obo:OBI_0000048 . obo:OBI_0000552 obo:IAO_0000111 "reverse transcribed polymerase chain reaction" ; obo:IAO_0000112 """Harmonisation of multi-centre real-time reverse-transcribed PCR results of a candidate prognostic marker in breast cancer: an EU-FP6 supported study of members of the EORTC - PathoBiology Group. Span PN, Sieuwerts AM, Heuvel JJ, Spyratos F, Duffy MJ, Eppenberger-Castori S, Vacher S, O'Brien K, McKiernan E, Pierce A, Vuaroqueaux V, Foekens JA, Sweep FC, Martens JW. Eur J Cancer. 2009 Jan;45(1):74-81. PMID: 19008094""" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "reverse transcribe pcr is a process which allow amplification of cDNA during a pcr reaction while the cDNA results from a retrotranscription of messenger RNA isolated from a material entity." ; obo:IAO_0000116 "3/21/10, BP:Modified definition to clarify that this is not the assay, but the material transformation" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "RT-PCR", "reverse transcription polymerase chain reaction" ; a owl:Class ; rdfs:label "reverse transcribed polymerase chain reaction" ; rdfs:subClassOf obo:OBI_0600058, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000415 [ a owl:Restriction ; owl:onProperty obo:RO_0002087 ; owl:someValuesFrom obo:OBI_0600028 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33697 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000406 ] . obo:OBI_0000553 obo:IAO_0000111 "Bruker Capillary LC-NMR platform" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Capillary LC-NMR is a hyphenated technique coupling capillary liquid chromatography and NMR, which increases sensitivity dramatically through the use of miniaturization of the chromatographic techniques and NMR detection volume. LC-NMR hyphenated systems separate a mixture into its pure components and couple the output to NMR for automatic sample analysis. The ever increasing need to measure lower sample amounts and lower level impurities demands the highest NMR sensitivity. Traditional LC-NMR systems with relatively large peak volumes are not optimized for such low levels of detection. Bruker BioSpin, together with Waters and Protasis has developed a Capillary LC-NMR system. The latest capillary LC attributes and highest capillary flow probe sensitivity combine with state of the art NMR systems technology. Greater mass sensitivity and faster spectral analysis with smaller sample volumes is possible. This system is ideal for analysis of metabolites and impurities associated with the drug development process." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400279" ; obo:IAO_0000232 "NMR instrument", "hyphenated NMR instrument platform" ; a owl:Class ; rdfs:label "Bruker Capillary LC-NMR platform" ; rdfs:subClassOf obo:OBI_0000596 . obo:OBI_0000554 obo:IAO_0000111 "gas chromatography oven" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A gas chromatography oven is an oven with a heated connection between the GC and the MS instrument in a GCMS-analysis, that keeps compounds in the gas phase as they leave the GC oven." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01039" ; obo:IAO_0000232 "gas chromatography equipment" ; a owl:Class ; rdfs:label "gas chromatography oven" ; rdfs:subClassOf obo:OBI_0000542 . obo:OBI_0000555 obo:IAO_0000111 "autosampler" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An optional part of an NMR instrument used to hold samples prior to NMR analysis and that sequentially loads these samples into the analytical part of the NMR instrument. n alt The autosampler is an automatic sample changer device." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400002" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "autosampler" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0000556 obo:IAO_0000111 "isocratic pump system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pump system optimized for isocratic chromatography." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01049" ; a owl:Class ; rdfs:label "isocratic pump system" ; rdfs:subClassOf obo:OBI_0000589 . obo:OBI_0000557 obo:IAO_0000111 "flash pump system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Any pump system used in flash column chromatography to push the solvent through the column. Better flow rates can be achieved by using a pump or by using compressed gas (e.g. air, nitrogen, or argon) to push the solvent through the column (flash column chromatography)." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01048" ; a owl:Class ; rdfs:label "flash pump system" ; rdfs:subClassOf obo:OBI_0000589 . obo:OBI_0000558 obo:IAO_0000111 "Varian UNITY INOVA spectrometer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The UNITY INOVA is also the easiest spectrometer to use and is also the choice of those interested in using advanced NMR techniques in their own research, but without becoming, or hiring, an NMR expert. A complete set of turnkey operating environments is available for the UNITY INOVA covering the structure and dynamics of biological macromolecules, small molecules, solids, and imaging. These packages put the combined NMR expertise of the entire Varian NMR community at your fingertips." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400236" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Varian UNITY INOVA spectrometer" ; rdfs:subClassOf obo:OBI_0000611 . obo:OBI_0000559 obo:IAO_0000111 "liquid NMR probe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR probe that is designed to hold a liquid sample." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400242" ; obo:IAO_0000232 "NMR device" ; a owl:Class ; rdfs:label "liquid NMR probe" ; rdfs:subClassOf obo:OBI_0000516 . obo:OBI_0000560 obo:IAO_0000111 "ion exchange column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An ion exchange column is a chromatography column that is used in ion exchange chromatography and anion or cation exchange resins to enable separation." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01105" ; a owl:Class ; rdfs:label "ion exchange column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000561 obo:IAO_0000111 "Bruker NMR probe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR probe that is manufactured by Bruker." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400231" ; obo:IAO_0000232 "NMR device, TODO: May need no definition." ; a owl:Class ; rdfs:label "Bruker NMR probe" ; rdfs:subClassOf obo:OBI_0000516 . obo:OBI_0000562 obo:IAO_0000111 "anion trap column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An anion trap column is a trap column and ion-exchange column which contains cationic anion-exchange resins." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01277" ; a owl:Class ; rdfs:label "anion trap column" ; rdfs:subClassOf obo:OBI_0000518 . obo:OBI_0000563 obo:IAO_0000111 "fluorescene detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A single wavelength detector, where the excitation light wavelength is normally a mercury lamp generated high intensity UV light at 253.7 nm. Many substances that fluoresce will be excited by light of this wavelength and hence be detected." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01080" ; a owl:Class ; rdfs:label "fluorescene detector" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000564 obo:IAO_0000111 "tecmag EAGLE probe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The Eagle is a 4 mm 1H/X solid-state MAS probe with a top spinning speed of 18 kHz. Its simple design is robust, reliable and easy to spin. Configurations are available for 200 to 600 MHz wide bore magnets on Tecmag, Bruker, Chemagnetics, JEOL and Varian spectrometers." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400248" ; obo:IAO_0000232 "NMR probe" ; a owl:Class ; rdfs:label "tecmag EAGLE probe" ; rdfs:subClassOf obo:OBI_0000479 . obo:OBI_0000565 obo:IAO_0000111 "electrical conductivity detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The electrical conductivity detector measures the conductivity of the mobile phase. There is usually background conductivity which must be backed-off by suitable electronic adjustments. If the mobile phase contains buffers, the detector gives a base signal that completely overwhelms that from any solute usually making detection impossible. Thus, the electrical conductivity detector a bulk property detector. and senses all ions whether they are from a solute or from the mobile phase. In order to prevent polarization of the sensing electrodes, AC voltages must be used and so it is the impedance not the resistance of the electrode system that is actually measured. From a physical chemistry stand point the conductivity of a solution is more important than its resistance. However, it is the resistance (impedance) of the electrode system that determines the current across it. The resistance of any conductor varies directly as its length and inversely as its cross sectional area." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01239" ; a owl:Class ; rdfs:label "electrical conductivity detector" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000566 obo:IAO_0000111 "NMR instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An Instrument which is used to carry out a NMR analysis of some sample." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "MRI scanner", "NMR instrument", "magnetic resonance imaging scanner" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400059" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "NMR instrument" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000567 obo:IAO_0000111 "Bruker UltraShield NMR magnet" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR magnet manufactured by Bruker that ensures field homogeneity without amplified effects from vibrations or thermal changes. This magnet technology uses active shielding and optimizes coil design." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400187" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Bruker UltraShield NMR magnet" ; rdfs:subClassOf obo:OBI_0000597 . obo:OBI_0000568 obo:IAO_0000111 "piston-seal" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The seal made by a piston in a diaphragm pump. The unique property of the reciprocating diaphragm pump is that the actuating piston does not come into direct contact with the mobile phase and thus, the demands on the piston-cylinder seal are not so great. The diaphragm has a relatively high surface area and thus, the movement of the diaphragm is relatively small and consequently the pump can be operated at a fairly high frequency. High frequency pumping results in a very significant reduction in pulse amplitude and, in addition, high frequency pulses are more readily damped by the column system. Nevertheless, it must be emphasized that diaphragm pumps are not pulseless." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01116" ; a owl:Class ; rdfs:label "piston-seal" ; rdfs:subClassOf obo:OBI_0000601 . obo:OBI_0000569 obo:IAO_0000111 "mass selective detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A mass selective detector is a GC detector that uses mass spectrometry. It is based upon the ionization of solute molecules in the ion source and the separation of the ions generated on the basis of their mass/charge ratio by an analyzer unit. This may be a magnetic sector analyzer, a quadruple mass filter, or an ion trap. Ions are detected by a dynode electron multiplier." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "mass spectrometry detector" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01198" ; a owl:Class ; rdfs:label "mass selective detector" ; rdfs:subClassOf obo:OBI_0000637 . obo:OBI_0000570 obo:IAO_0000111 "spin column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A spin column is a chromatography column which is suitable for putting it into a centrifuge. A spin column enforces separation through increased G-forces while spinning the column in a centrifuge. It is often used in DNA gel extraction kits." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01232" ; a owl:Class ; rdfs:label "spin column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000571 obo:IAO_0000111 "manufacturer role" ; obo:IAO_0000112 "With respect to The Accuri C6 Flow Cytometer System, the organization Accuri bears the role manufacturer role. With respect to a transformed line of tissue culture cells derived by a specific lab, the lab whose personnel isolated the cll line bears the role manufacturer role. With respect to a specific antibody produced by an individual scientist, the scientist who purifies, characterizes and distributes the anitbody bears the role manufacturer role." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Manufacturer role is a role which inheres in a person or organization and which is realized by a manufacturing process." ; obo:IAO_0000117 "GROUP: Role Branch" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "manufacturer role" ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:NCBITaxon_9606 obo:OBI_0000245 ) ] ], [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0000457 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000572 obo:IAO_0000111 "transfer line" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A combination of devices that are used in connection with a sampling head for transferring components of an applied sample to the analyzing part of a chromatography system." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01235" ; obo:IAO_0000232 "chromatography device" ; a owl:Class ; rdfs:label "transfer line" ; rdfs:subClassOf obo:OBI_0000048 . obo:OBI_0000573 obo:IAO_0000111 "gradient pump system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pump system optimized for gradient chromatography." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01050" ; a owl:Class ; rdfs:label "gradient pump system" ; rdfs:subClassOf obo:OBI_0000589 . obo:OBI_0000574 obo:IAO_0000111 "high temperature column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A high temperature column is a chromatography column which is suitable for and withstands very high temperatures in chromatography ovens." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01233" ; a owl:Class ; rdfs:label "high temperature column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000575 obo:IAO_0000111 "Bruker Ultrastabilized NMR magnet" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR magnet manufactured by Bruker for Ultra-High Field NMR, available from 750 MHz to 900 MHz, which provides reliable operation at reduced temperature and ambient pressure via being rigidly mounted and stabilized." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400188" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Bruker Ultrastabilized NMR magnet" ; rdfs:subClassOf obo:OBI_0000597 . obo:OBI_0000576 obo:IAO_0000111 "scattered molecular aggregate" ; obo:IAO_0000112 "the sodium and chloride ions in a glass of salt water" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a material entity that consists of all the molecules of a specific type that are located in some bounded region and which is part of a more massive material entity that has parts that are other such aggregates"@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en ; obo:IAO_0000118 "Collective"@en ; obo:IAO_0000119 "Discussion in Karslruhe with, among others, Alan Rector, Stefan Schulz, Marijke Keet, Melanie Courtot, and Alan Ruttenberg. With inspiration from the paper Granularity, scale and collectivity: When size does and does not matter, Alan Recto, Jeremy Rogers, Thomas Bittner, Journal of Biomedical Informatics 39 (2006) 333-349"@en ; a owl:Class ; rdfs:label "scattered molecular aggregate"@en ; rdfs:subClassOf obo:BFO_0000040, [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:CHEBI_23367 ], [ a owl:Restriction ; owl:allValuesFrom obo:CHEBI_23367 ; owl:onProperty obo:OBI_0000643 ] . obo:OBI_0000577 obo:IAO_0000111 "obsolete_molecular concentration" ; obo:IAO_0000112 "the phosphate concentration should be 0.1M" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A concentration is a relational quality that inheres in a material entity towards molecular scattered aggregate that is part of it by virtue of some ratio of masses of the two or the counts of the grains of the two or volume occupied by the larger material entity." ; obo:IAO_0000117 "PERSON: Alan Ruttenberg" ; obo:IAO_0000119 "Discussion in Karslruhe, Oct 2008, with, among others, Alan Rector, Stefan Schulz, Marijke Keet, Melanie Courtot, and Alan Ruttenberg." ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:Class ; rdfs:label "obsolete_molecular concentration" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000578 obo:IAO_0000111 "NMR sample tube" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The sample-tube holds the NMR sample and sits in the nmr probe. It is usually a glass tube of 5-20mm diameter." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400132" ; obo:IAO_0000232 "NMR device" ; a owl:Class ; rdfs:label "NMR sample tube" ; rdfs:subClassOf obo:OBI_0000836, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0000566 ] . obo:OBI_0000579 obo:IAO_0000111 "Varian UNITY spectrometer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The predecessor series of the Varian UNITY INOVA spectrometer." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400237" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Varian UNITY spectrometer" ; rdfs:subClassOf obo:OBI_0000611 . obo:OBI_0000580 obo:IAO_0000111 "AVANCE II spectrometer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A spectrometer suitable for metabolomics and in vivo NMR studies but structural analysis of small molecules and low molecular weight proteins can also be performed. To accomplish these studies there are six probe-heads available. A successor, the AVANCE III came out recently." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400197" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "AVANCE II spectrometer" ; rdfs:subClassOf obo:OBI_0000596 . obo:OBI_0000581 obo:IAO_0000111 "y-column connector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A column connector that connects one column on one side with two columns at the other side, hence building a Y shaped structure." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01237" ; a owl:Class ; rdfs:label "y-column connector" ; rdfs:subClassOf obo:OBI_0000478 . obo:OBI_0000582 obo:IAO_0000111 "Bruker LC-NMR/MS platform" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Includes the connection to a high-resolution TOF-LC-MS system." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400277" ; obo:IAO_0000232 "NMR instrument", "hyphenated NMR instrument platform" ; a owl:Class ; rdfs:label "Bruker LC-NMR/MS platform" ; rdfs:subClassOf obo:OBI_0000596 . obo:OBI_0000583 obo:IAO_0000111 "refractive index detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "For analyzing non-UV absorbing substances, such as carbohydrates, lipids and polymers. This is also the detector of choice for gel permeation chromatography. The refractive index detector is one of the least sensitive LC detectors. It is very sensitive to changes in ambient temperature, pressure changes, flow-rate changes and can not be used for gradient elution. Despite these many disadvantages, this detector is extremely useful for detecting those compounds that are nonionic, do not adsorb in the UV, and do not fluoresce. There are many optical systems used in refractive index detectors but one of the most common is the differential refractive index detector." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01081" ; a owl:Class ; rdfs:label "refractive index detector" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000584 obo:IAO_0000111 "anion exchange column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An anion exchange column is a chromatography column that is used in anion exchange chromatography and which enables the separation of anion mixtures." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01095" ; a owl:Class ; rdfs:label "anion exchange column" ; rdfs:subClassOf obo:OBI_0000560 . obo:OBI_0000586 obo:IAO_0000111 "plunger column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A plunger column is a chromatography column with adjustable heigth control. By means of an adjustable endpiece (plunger) the user can adjust the column length without disturbing the packed bed. Plunger columns can equalize volume changes and thus avoids dead volumes within the column." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01108" ; a owl:Class ; rdfs:label "plunger column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000588 obo:IAO_0000111 "flame photometric detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The determination of sulfur or phosphorus containing compounds is the job of the flame photometric detector (FPD). This device uses the chemiluminescent reactions of these compounds in a hydrogen/air flame as a source of analytical information that is relatively specific for substances containing these two kinds of atoms. The emitting species for sulfur compounds is excited S2. The lambda max for emission of excited S2 is approximately 394 nm. The emitter for phosphorus compounds in the flame is excited HPO (lambda max = doublet 510-526 nm). In order to selectively detect one or the other family of compounds as it elutes from the GC column, an interference filter is used between the flame and the photomultiplier tube (PMT) to isolate the appropriate emission band. The drawback here being that the filter must be exchanged between chromatographic runs if the other family of compounds is to be detected." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "FPD" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01091" ; a owl:Class ; rdfs:label "flame photometric detector" ; rdfs:subClassOf obo:OBI_0000637 . obo:OBI_0000589 obo:IAO_0000111 "chromatography pump system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Better flow rates can be achieved by using a pump or by using compressed gas (e.g. air, nitrogen, or argon) to push the solvent through the column (flash column chromatography)." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01046" ; a owl:Class ; rdfs:label "chromatography pump system" ; rdfs:subClassOf obo:OBI_0000485 . obo:OBI_0000590 obo:IAO_0000111 "Bruker 1mm MicroProbe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Over the past few years there has been a significantly growing demand for miniaturization in all areas ofmodern research and development. Evoked by many exciting applications, there is a need for analytical methods which require less amounts of sample. Bruker BioSpin meets this challenge with a revolutionary NMR probe design: The 1mm MicroProbe. It operates with disposable 1mm capillary sample tubes and the sample volume of 5 microliters enables the use of lowest amounts of sample to run all high resolution NMR experiments with outstanding sensitivity and up to 16 times faster measurements. Due to the TXI-type probe design, the z-gradient coil and the automatic matching and tuning accessory, the 1mm MicroProbe can be used for a wide variety of NMR experiments. The key advantages of this probe include:n up to 4 times higher mass sensitivity than 5mm conventional probes (with respect to the same sample amount)n excellent solvent suppression propertiesn virtually no salt effectn discrete samples in tubes that can be sealed and storedn automation accessory for sample preparation and handling available." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400194" ; obo:IAO_0000232 "NMR probe" ; a owl:Class ; rdfs:label "Bruker 1mm MicroProbe" ; rdfs:subClassOf obo:OBI_0000561 . obo:OBI_0000591 obo:IAO_0000111 "Bruker BEST NMR system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The introduction of biological screening and combinatorial chemistry for chemical synthesis has also introduced new requirements for NMR automation, e.g., the use of well plates for sample input, increased demands on throughput, and the need for quick and simple interpretation of the acquired NMR data." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "Bruker Efficient Sample Transfer NMR" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400206" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Bruker BEST NMR system" ; rdfs:subClassOf obo:OBI_0000464 . obo:OBI_0000592 obo:IAO_0000111 "chromatography detector filter" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An optical filter that is used to obtain monochromatic light of a defined wavelength from detector lamps." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01121" ; a owl:Class ; rdfs:label "chromatography detector filter" ; rdfs:subClassOf obo:OBI_0000601 . obo:OBI_0000593 obo:IAO_0000111 "cation trap column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cation trap column is a trap column and ion-exchange column which contains anionic cation-exchange resins." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01278" ; a owl:Class ; rdfs:label "cation trap column" ; rdfs:subClassOf obo:OBI_0000518 . obo:OBI_0000594 obo:IAO_0000111 "column adapter" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An Adapter that enabled the connection of a column to additional devices." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01113" ; obo:IAO_0000232 "chromatography device" ; a owl:Class ; rdfs:label "column adapter" ; rdfs:subClassOf obo:OBI_0000048 . obo:OBI_0000595 obo:IAO_0000111 "pulsed amperometric detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A chromatography detector as used by high-performance anion exchange chromatography that provides sensitive and specific detection of carbohydrates. Pulsed Electrochemical Detection (PED) allows simple, sensitive, and direct detection of numerous polar aliphatic compounds, especially carbohydrates. This technique exploits the electrocatalytic activity of noble metal electrode surfaces to oxidize various polar functional groups. In PED, multi-step potential-time waveforms at Au and Pt electrodes realize amperometric/coulometric detection while maintaining uniform and reproducible electrode activity. The response mechanisms in PED are dominated by the surface properties of the electrode, and, as a consequence, members of each chemical class of compounds produce virtually identical voltammetric responses. Thus, the full potential is realized when combined with high performance liquid chromatography (HPLC)." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "PAD" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01240" ; a owl:Class ; rdfs:label "pulsed amperometric detector" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000596 obo:IAO_0000111 "Bruker NMR instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR instrument that is manufactured by Bruker." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400198" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Bruker NMR instrument" ; rdfs:subClassOf obo:OBI_0000566 . obo:OBI_0000597 obo:IAO_0000111 "Bruker NMR magnet" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR magnet that is manufactured by Bruker." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400186" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Bruker NMR magnet" ; rdfs:subClassOf obo:OBI_0000517 . obo:OBI_0000598 obo:IAO_0000111 "ozone-induced chemiluminescence detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Although there are many direct ozone chemiluminescent reactions with various gaseous molecules, the incorporation of a conversion step to convert various non-chemiluminescent analytes to a species capable of reacting with ozone to produce chemiluminescence broadens the horizon of this technique tremendously. The conversion of nearly all nitrogen- and sulfur-containing compounds to their respective chemiluminescent species for universal nitrogen and sulfur detection has made nitrogen/sulfur chemiluminescence detection the most widely used analytical methods based upon ozone-induced chemiluminescence. In addition to non-chromatographic applications, nitrogen/sulfur chemiluminescence detection has been adapted to various chromatographic techniques from gas chromatography to liquid and supercritical fluid chromatography as specialized element-specific detectors. The characteristics of these detectors are evaluated and compared to other element-selective detection techniques. The unique features of the chemiluminescence detectors have made them powerful tools in many diverse fields of analytical chemistry." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01088" ; a owl:Class ; rdfs:label "ozone-induced chemiluminescence detector" ; rdfs:subClassOf obo:OBI_0000637 . obo:OBI_0000599 obo:IAO_0000111 "tecmag NMR console" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR console manufactured by tecmac." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400246" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "tecmag NMR console" ; rdfs:subClassOf obo:OBI_0000499 . obo:OBI_0000600 obo:IAO_0000111 "JEOL NMR instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR instrument that is manufactured by JEOL." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400226" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "JEOL NMR instrument" ; rdfs:subClassOf obo:OBI_0000566 . obo:OBI_0000601 obo:IAO_0000111 "chromatography consumable" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A chromatography consumable is a consumable that is used in a chromatography experiment." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01115" ; obo:IAO_0000232 "chromatography device" ; a owl:Class ; rdfs:label "chromatography consumable" ; rdfs:subClassOf obo:OBI_0000048 . obo:OBI_0000602 obo:IAO_0000111 "column frit" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A part of the column content that separates column packing compartments. In radial columns the packing is supported between two cylindrical frits and the gap between represents the bed height or column length. The outer frit is the column inlet and consequently the sample initially has a large area of stationary phase with which to interact. Frits are porous metal products to prevent unwanted particles from entering the chromatography system. These particles may come from the sample, the solvent or debris generated by the chromatography system itself. Such particles entering the system may lead to clogging of capillaries, interference with the chromatography by changing chromatographic parameters or disturbance of the detector function. Characteristics of a frit, besides the diameter and the thickness, is the porosity (pore distribution, density)." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01070" ; obo:IAO_0000232 "chromatography device" ; a owl:Class ; rdfs:label "column frit" ; rdfs:subClassOf obo:OBI_0000048 . obo:OBI_0000603 obo:IAO_0000111 "liquid chromatography column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A liquid chromatography column is a chromatography column that is used in liquid chromatography, i.e. a column that is provided with a liquid sample mix." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01227" ; a owl:Class ; rdfs:label "liquid chromatography column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000604 obo:IAO_0000111 "detector lamp" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A lamp used in a chromatography detector that excites sample molecules at certain frequencies / emission wavelengths, e.g. Mercury Vapor Lamp (253.7 nm), Zinc Vapor Lamp (2123.9 nm and 307.6 nm), Cadmium Vapor Lamp (228.8, 326.1,340.3, and 346.6 nm). To obtain monochromatic light an appropriate light filter would be needed." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01119" ; a owl:Class ; rdfs:label "detector lamp" ; rdfs:subClassOf obo:OBI_0000601 . obo:OBI_0000605 obo:IAO_0000111 "chart recorder" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The chart recorder is a device that transduces signal-intensities into a graphical peak output: As the separated components of the gas sample emerge into the detector, the change in voltage in the detecting bridge circuit causes a representative peak to be drawn on a chart recorder. The position of the peak along the time axis of the chart measures the component's retention time, which identifies the component. This is directly related to carrier gas flow rate, temperature and column packing and dimensions. The area under each peak is proportional to the concentration of the component of the sample. The area of the peaks inscribed on the chart recorder can be determined by multiplying the height of the peak in mm, by the width of the peak in mm at 1/2 the peak height. The calibration curves for use with the chart recorder are therefore peak area plotted against concentration." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01069" ; obo:IAO_0000232 "chromatography device" ; a owl:Class ; rdfs:label "chart recorder" ; rdfs:subClassOf obo:OBI_0000048 . obo:OBI_0000606 obo:IAO_0000111 "open tubular column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An open tubular column is a chromatography column in which the particles of the solid stationary phase or the support coated with a liquid stationary phase are concentrated on or along the inside tube wall leaving an open, unrestricted path for the mobile phase in the middle part of the tube." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01219" ; a owl:Class ; rdfs:label "open tubular column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000607 obo:IAO_0000111 "high resolution magic angle spin probe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Samples that are neither solid nor liquid, being of biological, chemical, or pharmaceutical interest, reveal highly resolved spectra when magic angle spinning is applied. The correct solution is a gradient, such that the field varies along the spinner axis. This so-called Magic Angle Gradient is employed in Brukers high resolution Magic Angle Spinning (hr-MAS) probes, and is implemented in such a way that it is compatible with the stator and does not interfere with the sample eject or insert. Bruker BioSpin has developed a series of dedicated probes for standard bore magnets to accommodate the rapidly expanding field of hr-MAS. These probes are available in double (e.g. 1H and 13C) and triple resonance (e.g. 1H, 13C, 15N) modes and come equipped with a deuterium lock channel. The probes have automatic sample ejection and insertion capability, with the availability of an optional sample changer, enabling fully automated sample runs. Probes can be equipped with an optional B0 gradient, directed along the magic angle, so that gradient spectroscopy can be done used." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "high resolution MAS, hr-MAS" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400192" ; obo:IAO_0000232 "NMR probe" ; a owl:Class ; rdfs:label "high resolution magic angle spin probe" ; rdfs:subClassOf obo:OBI_0000480 . obo:OBI_0000608 obo:IAO_0000111 "hydrogen generator" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A gas generator that generates hydrogen gas." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01035" ; a owl:Class ; rdfs:label "hydrogen generator" ; rdfs:subClassOf obo:OBI_0000507 . obo:OBI_0000609 obo:IAO_0000111 "glass column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A glass column is a chromatography column made out of glass that is usually used for larger scale and preparative liquid chromatography separations." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01101" ; a owl:Class ; rdfs:label "glass column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000610 obo:IAO_0000111 "auto injector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A gas chromatography device that can auto-inject a small number of samples an inlet." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01058" ; a owl:Class ; rdfs:label "auto injector" ; rdfs:subClassOf obo:OBI_0000504 . obo:OBI_0000611 obo:IAO_0000111 "Varian NMR instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR instrument that is manufactured by Varian." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400234" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Varian NMR instrument" ; rdfs:subClassOf obo:OBI_0000566 . obo:OBI_0000612 obo:IAO_0000111 "Bruker MATCH tube holder system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The Bruker Multiple Adjustable Tube Clamp Holder MATCH system is a holder for 100 mm long NMR sample tubes with diameters ranging from micro tubes up to 5 mm NMR tubes. The MATCH insert fits into a standard 10 mm Bruker spinner and is suitable for all non-spinning applications.n The MATCH system provides an easy and cost efficient means of optimizing the signal-to-noise ratio of each sample. By matching the NMR tube diameter to the size of the sample, most of the sample can be placed in the active column of the NMR coil. This leads to an enhanced signal detection compared to diluting the same sample quantity in a larger tube." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "Bruker Multiple Adjustable Tube Clamp Holder" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400211" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Bruker MATCH tube holder system" ; rdfs:subClassOf obo:OBI_0000484 . obo:OBI_0000613 obo:IAO_0000111 "Bruker SPE-NMR platform" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Solid Phase Extraction (SPE) system provides an interface between liquid chromatography (LC) and NMR. For the process of LC-SPE NMR a chromatographic separation is done and the peaks of interest are trapped on an individual SPE cartridge after the column. The peak selection is done either by UV detection or by evaluation of the on-line registered MS or MSn spectra." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400278" ; obo:IAO_0000232 "NMR instrument", "hyphenated NMR instrument platform" ; a owl:Class ; rdfs:label "Bruker SPE-NMR platform" ; rdfs:subClassOf obo:OBI_0000596 . obo:OBI_0000614 obo:IAO_0000111 "guard column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Guard columns are installed between the injection valve and the analytical or preparative column and here will remove contaminants and prolong the lifetime of the columns." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01111" ; obo:IAO_0000232 "chromatography device" ; a owl:Class ; rdfs:label "guard column" ; rdfs:subClassOf obo:OBI_0000048 . obo:OBI_0000615 obo:IAO_0000111 "protein expression profiling assay" ; obo:IAO_0000112 "Protein Expression Profiling During Chick Retinal Maturation: A Proteomics-based approach. PMID:19077203" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that determines protein expression and translation activity using protein extracts collected from a material entity." ; obo:IAO_0000117 "Phlippe Rocca-Serra" ; obo:IAO_0000118 "proteomic analysis" ; obo:IAO_0000119 "OBI branch derived" ; a owl:Class ; rdfs:label "protein expression profiling assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000000001 ] ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0000616 obo:IAO_0000111 "high resolution probe with automatic tuning and matching" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The Automatic Tuning and Matching (ATM) option for AVANCE spectrometers is available for double resonance probes in fixed-frequency and broadband tunable configurations with either direct or indirect detection. Thus, for multinuclear operation, as often required for applications in inorganic chemistry, ATM facilitates the accurate setting of 90 degree pulse widths on both observe and decoupling channels for each chosen nucleus and each individual sample - even with full automation. Triple resonance probes in fixed-frequency configurations, as typically used for inverse detection with high-field systems." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "High Resolution Probes with Automatic Tuning and Matching, HR_probe_with_ATM" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400224" ; obo:IAO_0000232 "NMR probe" ; a owl:Class ; rdfs:label "high resolution probe with automatic tuning and matching" ; rdfs:subClassOf obo:OBI_0000480 . obo:OBI_0000617 obo:IAO_0000111 "fluorine-induced chemiluminescence detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A gas chromatographic detection system based on the low pressure, gas phase chemiluminescence of the reaction mixture of molecular fluorine with organo-sulfur, -selenium, and -tellurium compounds separated from (gas phase) headspace samples. This detector was originally developed in the research group of John Birks at the University of Colorado, USA and was manufactured and sold by Sievers Instruments (Boulder Colorado, USA). This system can be divided up into three parts: the chromatograph, transfer line, and reaction cell; PMT and photon counting electronics; and the molecular fluorine generator." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01087" ; a owl:Class ; rdfs:label "fluorine-induced chemiluminescence detector" ; rdfs:subClassOf obo:OBI_0000637 . obo:OBI_0000618 obo:IAO_0000111 "size exclusion column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A size exclusion column is a chromatography column as used in size exclusion chromatography and which enables the separation of mixtures according to differrences in molecular size." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01100" ; a owl:Class ; rdfs:label "size exclusion column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000619 obo:IAO_0000111 "chromatography splitter" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An adjustable restriction that is placed in the waste outlet to allow the necessary pressure to develop at the column inlet to force a flow (q ml/min) through the column. If the flow of mobile phase is Q ml/min then the waste flow will be (Q-q) ml/min. by adjusting the waste flow, the proportion of the sample entering the capillary column can be varied over a wide range of values and the necessary minimum permissible volume for the particular column in use can be selected for analysis. Unfortunately, the fraction taken in this way may not be representative of the original sample. This is due to the individual solutes in the mixture having different diffusivities and, thus, they distribute themselves across the sampling tube in an irregular manner. In general, the components with higher diffusivities (e.g., those solutes of lower molecular weight) will diffuse away from the bulk sample more quickly than those having lower diffusivities." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01041" ; obo:IAO_0000232 "chromatography device" ; a owl:Class ; rdfs:label "chromatography splitter" ; rdfs:subClassOf obo:OBI_0000048 . obo:OBI_0000620 obo:IAO_0000111 "Bruker micro imaging probe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "For medical, biological and material sciences research, avance imaging systems provide optimal object handling and performance with a variety of samples types. Two classes of imaging probes are available: in vivo probes for handling and sustaining live objects such as animals and plants, and conventional imaging probes for materials samples." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400225" ; obo:IAO_0000232 "NMR probe" ; a owl:Class ; rdfs:label "Bruker micro imaging probe" ; rdfs:subClassOf obo:OBI_0000561 . obo:OBI_0000621 obo:IAO_0000111 "custom made column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A custom made column ia a chromatography column which is specifically tailored according to the needs of the separation as requested by a scientist or working group." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01234" ; a owl:Class ; rdfs:label "custom made column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000622 obo:IAO_0000111 "gel permeation column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A gel permeation column is a chromatography column which is used in gel permeation chromatography and which employs as the stationary phase a swollen gel made by polymerizing and cross-linking styrene in the presence of a diluent which is a nonsolvent for the styrene polymer. The polymer to be analyzed is introduced at the top of the column and then is elutriated with a solvent. The polymer molecules diffuse through the gel at rates depending on their molecular size." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01103" ; a owl:Class ; rdfs:label "gel permeation column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000623 obo:IAO_0000111 "NMR spectroscopy assay" ; obo:IAO_0000112 "Metabolic profiling studies on the toxicological effects of realgar in rats by (1)H NMR spectroscopy. Wei L, Liao P, Wu H, Li X, Pei F, Li W, Wu Y. Toxicol Appl Pharmacol. 2008 Nov 25. PMID: 19073202" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay that exploits the magnetic properties of certain nuclei (those with a spin) to resonate when placed in particular magnetic field conditions. Instruments recording NMR spectrum and sets of analysis can be used to deduce identity of chemical as well as composition of complex chemical mixtures." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "Nuclear magnetic resonance spectroscopy" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Nuclear_magnetic_resonance_spectroscopy" ; a owl:Class ; rdfs:label "NMR spectroscopy assay" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0000624 obo:IAO_0000111 "Bruker SampleJet system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Bruker BioSpin introduces the SampleJet, a robot for NMR tube automation. The SampleJet has been consciously designed to meet the growing customer demand for simplicity, versatility and higher throughput in NMR sample tube automation.n The SampleJet utilizes the modern-day industry standard for sample arrangements-the 96 well plate array. Therefore, the samples may be handled by standard lab automation devices before or after the NMR measurement." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400208" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Bruker SampleJet system" ; rdfs:subClassOf obo:OBI_0000464 . obo:OBI_0000625 obo:IAO_0000111 "JEOL ECX NMR spectrometer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The ECX series of NMR spectrometers is designed for any laboratory needing an easy-to-use, reliable, routine NMR system. The ECX NMR series is available from 300 to 500 MHz. The console is designed around a modular, digital NMR electronics chassis controlled by an intelligent acquisition computer. For unprecedented flexibility, the JEOL NMR system offers a Windows XP, Mac OSX or LINUX. Both the workstation and spectrometer may be connected to a standard network, allowing seamless remote operation anywhere in the world." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400227" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "JEOL ECX NMR spectrometer" ; rdfs:subClassOf obo:OBI_0000600 . obo:OBI_0000626 obo:IAO_0000111 "DNA sequencing assay" ; obo:IAO_0000112 "Illumina (Solexa) sequencing is an example of DNA sequencing" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A sequencing assay which determines information on the sequence of a DNA molecule." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "nucleotide sequencing" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/DNA_sequencing" ; a owl:Class ; rdfs:label "DNA sequencing assay" ; rdfs:subClassOf obo:OBI_0600047 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600047 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400103 ] ) ] [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001573 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000811 ] ] ) ] . obo:OBI_0000627 obo:IAO_0000111 "quaternary pump system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pump system that pump and mix up to four different solvents in parallel." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01047" ; a owl:Class ; rdfs:label "quaternary pump system" ; rdfs:subClassOf obo:OBI_0000589 . obo:OBI_0000628 obo:IAO_0000111 "carbon nanotube column" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Carbon nanotubes (CNTs) are known to have high thermal and mechanical stability and have the potential to be high-performance separation media that utilize the nanoscale interactions. CNT can be applied in long capillary tubes for the development of gas chromatography columns. A film of CNTs can be deposited by chemical vapor deposition (CVD) to form the stationary phase in the open tubular format. Altering the CVD conditions can vary the thickness and the morphology of the CNT film, which opens the possibility of selectivity tuning. The ability to fabricate long tubes coated with CNTs can be readily employed in other gas- and liquid-phase separations as well." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01107" ; a owl:Class ; rdfs:label "carbon nanotube column" ; rdfs:subClassOf obo:OBI_0000038 . obo:OBI_0000629 obo:IAO_0000111 "Bruker solid magic angle spinning probe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Magic angle spinning, nowadays a routine technique for solids NMR, still offers the capability of innovation. The high mechanical performance of MAS probes in conjunction with efficient rf pulse techniques open new exciting fields in solids NMR of biological samples and in the field of quadrupolar nuclei." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "solid MAS probe" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400193" ; obo:IAO_0000232 "NMR probe" ; a owl:Class ; rdfs:label "Bruker solid magic angle spinning probe" ; rdfs:subClassOf obo:OBI_0000561 . obo:OBI_0000630 obo:IAO_0000111 "hematology assay" ; obo:IAO_0000112 "Co-associations between insulin sensitivity and measures of liver function, subclinical inflammation, and hematology._PMID:18702943" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay that studies blood and blood producing organs using a variety of techniques and instruments" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "blood analysis", "haematology" ; obo:IAO_0000119 "OBI branch derived" ; a owl:Class ; rdfs:label "hematology assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:IAO_0000030 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0030097 ] ) ] ] . obo:OBI_0000631 obo:IAO_0000111 "Varian MERCURY spectrometer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "MERCURYplus spectrometers provide superior control, stability, and performance for high-productivity environments. Surface-mount electronics enable a small footprint without compromising data quality. Modular design allows flexible configuration. Direct digital synthesis, linear amplifiers, and other innovative RF and digital technologies enable push-button operation." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400235" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "Varian MERCURY spectrometer" ; rdfs:subClassOf obo:OBI_0000611 . obo:OBI_0000632 obo:IAO_0000111 "Bruker Metabolic Profiler" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR platform for conducting metabonomics studies, traditional metabolism studies, and analysis of complex mixtures, featuring an Avance NMR spectrometer and a microTOF from Bruker Daltonics. By combining the structural resolving power of NMR with mass accuracy of the microTOF Bruker offers a complete system for metabolic research. The Metabolic Profiler provides a simple, easy to use and inexpensive base-system to acquire the spectroscopic data, needed to do basic metabolic profiling including metabonomic statistical analysis." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400199" ; obo:IAO_0000232 "NMR instrument", "hyphenated NMR instrument platform" ; a owl:Class ; rdfs:label "Bruker Metabolic Profiler" ; rdfs:subClassOf obo:OBI_0000596 . obo:OBI_0000633 obo:IAO_0000111 "column heater" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The glass liner can be fitted with a separate heater and the volatilization temperature can, thus, be controlled. This flash heater system is available in most chromatographs. By using a syringe with a long needle, the tip can be made to penetrate past the liner and discharge its contents directly into the column packing. This procedure is called 'on-column injection' and, as it reduces peak dispersion on injection and thus, provides higher column efficiencies, is often the preferred procedure." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01040" ; a owl:Class ; rdfs:label "column heater" ; rdfs:subClassOf obo:OBI_0000485 . obo:OBI_0000634 obo:IAO_0000111 "DNA methylation profiling assay" ; obo:IAO_0000112 "Genome-wide, high-resolution DNA methylation profiling using bisulfite-mediated cytosine conversion. Reinders J, Delucinge Vivier C, Theiler G, Chollet D, Descombes P, Paszkowski J._PMID:18218979" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An assay that measures the state of methylation of DNA molecules using genomic DNA collected from a material entity using a range of techniques and instrument such as DNA sequencers and often relying on treatment with bisulfites to ensure cytosine conversion." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "DNA methylation profiling" ; obo:IAO_0000119 "OBI branch derived" ; a owl:Class ; rdfs:label "DNA methylation profiling assay" ; rdfs:subClassOf obo:OBI_0002020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_16991 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000027 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0006306 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001234 ] . obo:OBI_0000635 obo:IAO_0000111 "JEOL CapNMR probe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The JEOL ECA and ECX NMR spectrometers now support the MRM/Protasis CapNMR Probe for well plate-based and microvial-based NMR analysis. The CapNMR probe is available at proton frequencies ranging from 300 MHz to 800 MHz in both indirect configurations (e.g. 1H{13C} and 1H {31P}) and also in triple resonance configurations (e.g. 1H{13C, 15N}, 1H{31P, 15N}). Both employ a high-strength z-directed field gradient. The flowprobes come with the choice of two flowcell volumes: a 5 μl flowcell with an NMR active volume of 2.5 μl, and a 10 μl flowcell with an NMR active volume of 5 μl. The fluidic connections are 75 μm i.d. and 1/32 o.d. FEP Teflon with hastelloy unions for exceptional solvent compatibility." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400233" ; obo:IAO_0000232 "NMR probe" ; a owl:Class ; rdfs:label "JEOL CapNMR probe" ; rdfs:subClassOf obo:OBI_0000529 . obo:OBI_0000636 obo:IAO_0000111 "acquisition computer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Computer used for NMR, can be divided into central processing unit (CPU), consisting of instruction, interpretation and arithmetic unit plus fast access memory, and peripheral devices such as bulk data storage and input and output devices (including, via the interface, the spectrometer). Under software control, the computer controls the RF pulses and gradients necessary to acquire data, and process the data to produce spectra or images. Note that devices such as the spectrometer may themselves incorporate small computers." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400013" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "acquisition computer" ; rdfs:subClassOf obo:OBI_0400107, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000392 ] . obo:OBI_0000637 obo:IAO_0000111 "gas chromatography detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A gas chromatography detector is a chromatography detector that locates in the dimensions of space and time, the positions of the components of a mixture that has been subjected to a gas chromatographic process and thus permits the senses to appreciate the nature of the separation. There is no LC detector that has an equivalent performance to the flame ionization detector (FID) used in GC. In general, LC detectors have sensitivities of two to three orders of magnitude less than their GC counterparts and linear dynamic ranges one to two orders of magnitude lower. Only highly specific LC detectors have sensitivities that can approach those of GC detectors." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "FID" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01083" ; obo:IAO_0000232 "chromatography detector, defined class/xps" ; a owl:Class ; rdfs:label "gas chromatography detector" ; rdfs:subClassOf obo:OBI_0000481 . obo:OBI_0000638 obo:IAO_0000111 "gas purifier" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Gas purifiers are instruments used for the removal of gas impurities like hydrocarbons, oxygen, and moisture from carrier gas and fuel gases for GC or GC-MS systems." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01036" ; obo:IAO_0000232 "gas chromatography equipment" ; a owl:Class ; rdfs:label "gas purifier" ; rdfs:subClassOf obo:OBI_0000542 . obo:OBI_0000639 obo:IAO_0000111 "material separation objective" ; obo:IAO_0000112 "The objective to obtain multiple aliquots of an enzyme preparation. The objective to obtain cells contained in a sample of blood." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "is an objective to transform a material entity into spatially separated components." ; obo:IAO_0000117 "PPPB branch" ; obo:IAO_0000119 "PPPB branch" ; a owl:Class ; rdfs:label "material separation objective" ; rdfs:subClassOf obo:OBI_0000456 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:OBI_0000678 obo:OBI_0000681 ) ] . obo:OBI_0000640 obo:IAO_0000111 "indirect detection probe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An NMR probe designed to allow the indirect detection of acquisition nuclei." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400281" ; obo:IAO_0000232 "NMR device" ; a owl:Class ; rdfs:label "indirect detection probe" ; rdfs:subClassOf obo:OBI_0000516 . obo:OBI_0000641 obo:IAO_0000111 "JEOL ECA NMR spectrometer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The ECA series of NMR spectrometers is a high performance, research grade NMR system configurable to a wide range off applications. The ECA NMR is available from 300 to 930 MHz field strengths and is 1GHz ready. The system is designed around a modular, digital NMR electronics chassis controlled from a UNIX or Windows workstation and acquisition system. Both the workstation and spectrometer may be connected to a standard network, allowing seamless remote operation anywhere in the world." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/NMR.owl#msi_400228" ; obo:IAO_0000232 "NMR instrument" ; a owl:Class ; rdfs:label "JEOL ECA NMR spectrometer" ; rdfs:subClassOf obo:OBI_0000600 . obo:OBI_0000642 obo:IAO_0000111 "atomic emission detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Instead of measuring simple gas phase (carbon containing) ions created in a flame as with the flame ionization detector, or the change in background current because of electronegative element capture of thermal electrons as with the electron capture detector, the AED has a much wider applicability because it is based on the detection of atomic emissions. The strength of the AED lies in the detector's ability to simultaneously determine the atomic emissions of many of the elements in analytes that elute from a GC capillary column (called eluants or solutes in some books). As eluants come off the capillary column they are fed into a microwave powered plasma (or discharge) cavity where the compounds are destroyed and their atoms are excited by the energy of the plasma. The light that is emitted by the excited particles is separated into individual lines via a photodiode array. The associated computer then sorts out the individual emission lines and can produce chromatograms made up of peaks from eluants that contain only a specific element." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000118 "AED" ; obo:IAO_0000119 "WEB:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01086" ; a owl:Class ; rdfs:label "atomic emission detector" ; rdfs:subClassOf obo:OBI_0000637 . obo:OBI_0000643 obo:IAO_0000111 "has grain" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "the relation of the cells in the finger of the skin to the finger, in which an indeterminate number of grains are parts of the whole by virtue of being grains in a collective that is part of the whole, and in which removing one granular part does not nec- essarily damage or diminish the whole. Ontological Whether there is a fixed, or nearly fixed number of parts - e.g. fingers of the hand, chambers of the heart, or wheels of a car - such that there can be a notion of a single one being missing, or whether, by contrast, the number of parts is indeterminate - e.g., cells in the skin of the hand, red cells in blood, or rubber molecules in the tread of the tire of the wheel of the car." ; obo:IAO_0000116 "Discussion in Karslruhe with, among others, Alan Rector, Stefan Schulz, Marijke Keet, Melanie Courtot, and Alan Ruttenberg. Definition take from the definition of granular parthood in the cited paper. Needs work to put into standard form"@en ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en ; obo:IAO_0000119 "PAPER: Granularity, scale and collectivity: When size does and does not matter, Alan Rector, Jeremy Rogers, Thomas Bittner, Journal of Biomedical Informatics 39 (2006) 333-349" ; a owl:ObjectProperty ; rdfs:label "has grain" ; rdfs:subPropertyOf obo:BFO_0000051 . obo:OBI_0000644 obo:IAO_0000111 "obsoleted_is_specified_information_intput_of" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Is the inverse relation of has_specfied_input_information" ; obo:IAO_0000116 "is replaced by is_specified_intput_of" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:ObjectProperty ; rdfs:label "obsoleted_is_specified_information_intput_of" ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:OBI_0000645 obo:IAO_0000111 "is grain of" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A relation between granular parts and the whole of which they are a part. Granular parts have indeterminate number such that removing one granular part does not necessarily damage or diminish the whole." ; obo:IAO_0000116 "JAO: Added definition 2013-10-25 based on 'has grain', but both these terms seem problematic." ; obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en ; obo:IAO_0000119 "Discussion in Karslruhe with, among others, Alan Rector, Stefan Schulz, Marijke Keet, Melanie Courtot, and Alan Ruttenberg. With inspiration from the paper Granularity, scale and collectivity: When size does and does not matter, Alan Recto, Jeremy Rogers, Thomas Bittner, Journal of Biomedical Informatics 39 (2006) 333-349"@en ; a owl:ObjectProperty ; rdfs:label "is grain of"@en ; rdfs:subPropertyOf obo:BFO_0000050 . obo:OBI_0000646 obo:IAO_0000111 "provisions" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A relation between an organisation or person and a material entity, where the organization or person provides or supplies the material entity for others to use" ; obo:IAO_0000116 "5/11/2020: A prior definition contained reference to transfer of ownership. (\"A relation between an organisation or person and a material entity who owned or has license to the material entity and there was a legal transfer of ownership or licensing of the material entity to the current owner\"). This was left out as it was hard to read and it was unclear if/how that transfer restricts the relationship." ; obo:IAO_0000117 "GROUP: Relations branch" ; obo:IAO_0000118 "supplies" ; a owl:ObjectProperty ; rdfs:label "provisions" ; owl:inverseOf obo:OBI_0000647 . obo:OBI_0000647 obo:IAO_0000111 "has_supplier" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A relation between a material entity and an organisation or person who owned or has license to the material entity and there was a legal transfer of ownership or licensing of the material entity to the current owner." ; obo:IAO_0000117 "PERSON: Alan Rutternberg", "PERSON: Cristian Cocos", "PERSON: Frank Gibson", "PERSON: Melanie Courtot" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "has_supplier" ; rdfs:range [ a owl:Class ; owl:unionOf (obo:NCBITaxon_9606 obo:OBI_0000245 ) ] . obo:OBI_0000648 obo:IAO_0000111 "clustered data set" ; obo:IAO_0000112 "A clustered data set is the output of a K means clustering data transformation" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A data set that is produced as the output of a class discovery data transformation and consists of a data set with assigned discovered class labels."@en ; obo:IAO_0000117 "PERSON: James Malone", "PERSON: Monnie McGee" ; obo:IAO_0000118 "data set with assigned discovered class labels" ; obo:IAO_0000232 "AR thinks could be a data item instead" ; a owl:Class ; rdfs:label "clustered data set"@en ; rdfs:subClassOf obo:IAO_0000100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0200175 ] . obo:OBI_0000649 obo:IAO_0000111 "data set of features" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A data set that is produced as the output of a descriptive statistical calculation data transformation and consists of producing a data set that represents one or more features of interest about the input data set."@en ; obo:IAO_0000117 "PERSON: James Malone", "PERSON: Monnie McGee" ; a owl:Class ; rdfs:label "data set of features"@en ; rdfs:subClassOf obo:IAO_0000100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0200184 ] . obo:OBI_0000650 obo:IAO_0000111 "differential expression analysis data transformation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A differential expression analysis data transformation is a data transformation that has an objective of differential expression analysis. Frequently this data transformation involves summarizing or otherwise aggregating signals from various samples categorized into groups, and calculating measures of group differences from these aggregated signals."@en ; obo:IAO_0000117 "Dan Berrios", "James Malone"@en, "Melanie Courtot"@en, "Monnie McGee"@en ; obo:IAO_0000119 "WEB:"@en ; a owl:Class ; rdfs:label "differential expression analysis data transformation"@en ; rdfs:subClassOf obo:OBI_0200000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200031 ] . obo:OBI_0000651 obo:IAO_0000111 "urine specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a portion of urine collected from an organism" ; obo:IAO_0000116 "4/10/2011BP: It seems to me that the editor notes refer to a previous version, and are no longer relevant.", "This could be instead a kind of collection of secreted stuff. Among secreted stuff there is passive, and active. urine is secreted, passiv. lavage is secreted, active", "are we happy calling collection of urine a material separation?" ; a owl:Class ; rdfs:label "urine specimen" ; rdfs:subClassOf obo:OBI_0001479, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0001088 ] . obo:OBI_0000652 obo:IAO_0000111 "material combination" ; obo:IAO_0000112 "Mixing two fluids. Adding salt into water. Injecting a mouse with PBS." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "is a material processing with the objective to combine two or more material entities as input into a single material entity as output." ; obo:IAO_0000116 "created at workshop as parent class for 'adding material into target', which is asymmetric, while combination encompasses all addition processes." ; obo:IAO_0000117 "bp" ; obo:IAO_0000119 "bp" ; a owl:Class ; rdfs:label "material combination" ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:BFO_0000040 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:BFO_0000040 ] ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000686 ] . obo:OBI_0000653 obo:IAO_0000111 "fuzzy clustering objective"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A fuzzy clustering objective is a data transformation objective where the aim is to assign input objects (typically vectors of attributes) a probability that a point belongs to a class, where the number of class and their specifications are not known a priori."@en ; obo:IAO_0000117 "James Malone"@en ; obo:IAO_0000119 "PERSON: James Malone", "PERSON: Ryan Brinkman" ; a owl:Class ; rdfs:label "fuzzy clustering objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0000654 obo:IAO_0000111 "device setting" ; obo:IAO_0000112 "Examples, 300V for 4 hours, 200mvolts, 37degrees.A knob set a 300 V is the device setting, the protocol stating to set the instrument to 300V is a device setting specification" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a quality inheres_in some device and is concretization of some (device_setting_specification and is_about a quality of the device" ; obo:IAO_0000116 "There is some question of whether 'device setting' is really best modelled as a quality. To be revisited after assay terms have been worked through. See https://github.com/obi-ontology/obi/issues/133" ; obo:IAO_0000117 "PERSON: Frank Gibson" ; a owl:Class ; rdfs:label "device setting" ; rdfs:subClassOf obo:BFO_0000019, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000047 ] . obo:OBI_0000655 obo:IAO_0000111 "blood specimen" ; obo:IAO_0000112 "blood drawn from a human for glucose assay" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "a material entity derived from a portion of blood collected from an organism" ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "Bjoern Peters" ; a owl:Class ; rdfs:label "blood specimen" ; rdfs:subClassOf obo:OBI_2000009, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0000178 ] . obo:OBI_0000656 obo:IAO_0000111 "data set of predicted values according to fitted curve" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A data set which is the output of a curve fitting data transformation in which the aim is to find a curve which matches a series of data points and possibly other constraints."@en ; obo:IAO_0000117 "PERSON: James Malone", "PERSON: Monnie McGee" ; a owl:Class ; rdfs:label "data set of predicted values according to fitted curve"@en ; rdfs:subClassOf obo:IAO_0000100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0200072 ] . obo:OBI_0000658 obo:IAO_0000111 "data representational model" ; obo:IAO_0000112 "gene regulatory graph model", "phylogenetic tree", "protein interaction network" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Data representational model is an information content entity of the relationships between data items. A data representational model is encoded in a data format specification such as for cytoscape or biopax." ; obo:IAO_0000117 "Melanie Courtot" ; obo:IAO_0000118 "data structure", "data structure specification" ; obo:IAO_0000119 "GROUP: OBI" ; obo:IAO_0000232 "2009-02-28: work on this term has been finalized during the OBI workshop winter 2009" ; a owl:Class ; rdfs:label "data representational model" ; rdfs:subClassOf obo:IAO_0000033 . obo:OBI_0000659 obo:IAO_0000111 "specimen collection process" ; obo:IAO_0000112 "drawing blood from a patient for analysis, collecting a piece of a plant for depositing in a herbarium, buying meat from a butcher in order to measure its protein content in an investigation" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A planned process with the objective of collecting a specimen." ; obo:IAO_0000116 "Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation.", "Philly2013: A specimen collection can have as part a material entity acquisition, such as ordering from a bank. The distinction is that specimen collection necessarily involves the creation of a specimen role. However ordering cell lines cells from ATCC for use in an investigation is NOT a specimen collection, because the cell lines already have a specimen role.", "Philly2013: The specimen_role for the specimen is created during the specimen collection process.", """label changed to 'specimen collection process' on 10/27/2014, details see tracker: http://sourceforge.net/p/obi/obi-terms/716/""" ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000118 "specimen collection" ; obo:IAO_0000232 "5/31/2012: This process is not necessarily an acquisition, as specimens may be collected from materials already in posession", "6/9/09: used at workshop" ; a owl:Class ; rdfs:label "specimen collection process" ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:BFO_0000040 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0100051 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000011 [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000684 ] ) ] . obo:OBI_0000660 obo:IAO_0000111 "background corrected data set" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A data set that is produced as the output of a background correction data transformation."@en ; obo:IAO_0000117 "PERSON: James Malone", "PERSON: Melanie Courtot" ; a owl:Class ; rdfs:label "background corrected data set"@en ; rdfs:subClassOf obo:IAO_0000100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000666 ] . obo:OBI_0000661 obo:IAO_0000111 "enzyme-linked immunosorbent assay" ; obo:IAO_0000112 "1) Detection of IL-2 (analyte) in a cell supernatant (evaluant), using plate bound anti IL-2 antibodies, and a reporter enzyme-linked reporter antibody. 2) Measurement of IgG antibody (analyte) titer in a serum sample (evaluant) using plate bound antigen and a reporter anti-IgG antibody." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay where binding of an enzyme linked antibody to a material entity that is immobilized on solid support is detected utilizing a chemiluminescent reaction. Depending on the setup, the enzyme-linked antibody could be binding directly to the analyte, or it serves as a secondary antibody detecting binding of the primary antibody to the analyte." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000118 "ELISA" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "enzyme-linked immunosorbent assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042571 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:GO_0042571 ] ) ] . obo:OBI_0000662 obo:IAO_0000111 "error corrected data set" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A data set that is produced as the output of an error correction data transformation and consists of producing a data set which has had erroneous contributions from the input to the data transformation removed (corrected for)."@en ; obo:IAO_0000117 "PERSON: James Malone", "PERSON: Monnie McGee" ; a owl:Class ; rdfs:label "error corrected data set"@en ; rdfs:subClassOf obo:IAO_0000100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000668 ] . obo:OBI_0000663 obo:IAO_0000111 "class prediction data transformation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A class prediction data transformation (sometimes called supervised classification) is a data transformation that has objective class prediction."@en ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000118 "supervised classification data transformation" ; obo:IAO_0000119 "PERSON: James Malone"@en ; a owl:Class ; rdfs:label "class prediction data transformation"@en ; rdfs:subClassOf obo:OBI_0200000 ; owl:equivalentClass [ a owl:Class ; owl:unionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000023 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200179 ] ) ] . obo:OBI_0000664 obo:IAO_0000111 "BrdU incorporation assay" ; obo:IAO_0000112 "The measurement of T cell proliferation as a response to a viral peptide by culturing T cells stimulated with APCs and peptide in the presence of BrdU." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cell proliferation assay in which cells are cultured in the presence of BrdU which is incorporated into newly synthesized DNA of replicating cells (during the S phase of the cell cycle), substituting for thymidine during DNA replication, which can be quantified by BrdU specific antibodies." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "BrdU incorporation assay" ; rdfs:subClassOf obo:OBI_0000891, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002743 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_472552 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_472552 ] ) ] . obo:OBI_0000665 obo:IAO_0000111 "obsolete intracellular cytokine staining assay" ; obo:IAO_0000112 "Permeabilizing T cells and staining them with fluorescent labeled anti-IFN-gamma antibodies" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The measurement of cytokines within the cytoplasm of a cell by permeabilizing the cell membrane to allow entry of specific antibodies, and counting the stained cells using a flow cytometer." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000118 "ICCS", "ICS" ; obo:IAO_0000119 "IEDB" ; obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:OBI_0000916 ; obo:OBI_9991118 "intracellular cytokine staining (ICS)" ; a owl:Class ; rdfs:label "obsolete intracellular cytokine staining assay" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000666 obo:IAO_0000111 "background correction data transformation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A background correction data transformation (sometimes called supervised classification) is a data transformation that has the objective background correction."@en ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "PERSON: James Malone"@en ; a owl:Class ; rdfs:label "background correction data transformation"@en ; rdfs:subClassOf obo:OBI_0200000 ; owl:equivalentClass [ a owl:Class ; owl:unionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000660 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200173 ] ) ] . obo:OBI_0000667 obo:IAO_0000111 "obsolete MHC multimer staining assay" ; obo:IAO_0000112 "Measuring T cells that are specific for the SYFPEITHI peptide when presented by the murine MHC molecule H-2 Kd by staining them with a tetramer of peptide loaded MHC complexes." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An MHC multimer assay is an assay that detects T cells capable of binding the MHC:ligand complexes present in the multimer. The multimer is fluorescently labelled. The T cells bound to multimers are counted in a flow cytometer" ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000118 "MHC tetramer assay" ; obo:IAO_0000119 "IEDB" ; obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:OBI_1110179 ; obo:OBI_9991118 "MHC tetramer/multimer staining" ; a owl:Class ; rdfs:label "obsolete MHC multimer staining assay" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000668 obo:IAO_0000111 "error correction data transformation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An error correction data transformation is a data transformation that has the objective of error correction, where the aim is to remove (correct for) erroneous contributions from the input to the data transformation."@en ; obo:IAO_0000117 "James Malone"@en, "Monnie McGee" ; obo:IAO_0000119 "EDITORS" ; a owl:Class ; rdfs:label "error correction data transformation"@en ; rdfs:subClassOf obo:OBI_0200000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200186 ] . obo:OBI_0000669 obo:IAO_0000111 "tritiated thymidine incorporation assay" ; obo:IAO_0000112 "The measurement of T cell proliferation as a response to a viral peptide by culturing T cells stimulated with APCs and peptide in the presence of tritiated thymidine, and using a scintillation counter to detect the radioactivity." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cell proliferation assay in which cells are cultured in the presence of tritiated thymidine which is incorporated into newly synthesized DNA of replicating cells (during the S phase of the cell cycle). The radioactivity of tritiated thymidine in a cell is a proxy for cells that were actively replicating." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "tritiated thymidine incorporation assay" ; rdfs:subClassOf obo:OBI_0000891, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002743 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_53526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_53526 ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000201 obo:OBI_0003368 ) ] ] . obo:OBI_0000671 obo:IAO_0000111 "sample from organism" ; obo:IAO_0000114 obo:IAO_0000002 ; obo:IAO_0000115 "a material obtained from an organism in order to be a representative of the whole" ; obo:IAO_0000116 "5/29: This is a helper class for now", "we need to work on this: Is taking a urine sample a material separation process? If not, we will need to specify what 'taking a sample from organism' entails. We can argue that the objective to obtain a urine sample from a patient is enough to call it a material separation process, but it could dilute what material separation was supposed to be about." ; a owl:Class ; rdfs:label "sample from organism" ; rdfs:subClassOf obo:OBI_0000747, obo:OBI_0001479, [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0000465 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000740 ] ) ] . obo:OBI_0000673 obo:IAO_0000111 "statistical hypothesis test"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A statistical hypothesis test data transformation is a data transformation that has objective statistical hypothesis test."@en ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "PERSON: James Malone"@en ; a owl:Class ; rdfs:label "statistical hypothesis test"@en ; rdfs:subClassOf obo:OBI_0200000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000675 ] . obo:OBI_0000674 obo:IAO_0000111 "center value" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A data item that is produced as the output of a center calculation data transformation and represents the center value of the input data."@en ; obo:IAO_0000117 "PERSON: James Malone", "PERSON: Monnie McGee" ; obo:IAO_0000118 "median" ; a owl:Class ; rdfs:label "center value"@en ; rdfs:subClassOf obo:IAO_0000027 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0200181 ] . obo:OBI_0000675 obo:IAO_0000111 "statistical hypothesis test objective"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is a data transformation objective where the aim is to estimate statistical significance with the aim of proving or disproving a hypothesis by means of some data transformation." ; obo:IAO_0000117 "James Malone"@en, "Person:Helen Parkinson" ; obo:IAO_0000118 "hypothesis test objective" ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Statistical_hypothesis_testing" ; a owl:Class ; rdfs:label "statistical hypothesis test objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0000676 obo:IAO_0000111 "reduced dimension data set" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A data set that is produced as the output of a data vector reduction data transformation and consists of producing a data set which has fewer vectors than the input data set."@en ; obo:IAO_0000117 "PERSON: James Malone", "PERSON: Monnie McGee" ; a owl:Class ; rdfs:label "reduced dimension data set"@en ; rdfs:subClassOf obo:IAO_0000100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0200182 ] . obo:OBI_0000678 obo:IAO_0000111 "portioning objective" ; obo:IAO_0000112 "The objective to obtain multiple aliquots of an enzyme preparation." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A material separation objective aiming to separate material into multiple portions, each of which contains a similar composition of the input material." ; a owl:Class ; rdfs:label "portioning objective" ; rdfs:subClassOf obo:OBI_0000639 ; owl:disjointWith obo:OBI_0000681 . obo:OBI_0000679 obo:IAO_0000111 "average value" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A data item that is produced as the output of an averaging data transformation and represents the average value of the input data."@en ; obo:IAO_0000117 "PERSON: James Malone", "PERSON: Monnie McGee" ; obo:IAO_0000118 "arithmetic mean" ; a owl:Class ; rdfs:label "average value"@en ; rdfs:subClassOf obo:IAO_0000027 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0200170 ] . obo:OBI_0000680 obo:IAO_0000111 "whole organism preparation" ; obo:IAO_0000112 "putting a mouse in the blender. Not: putting a mouse on a scale" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A material entity which is the output of a process in which one or more whole organisms are prepared in a way to make it easier to study them, and in which the great majority of organismal parts are maintained" ; obo:IAO_0000116 "does this include injecting a dye to a patient to be able to visualize parts of his brain? If not, we should state that the components of the organism are substantially re-arranged." ; a owl:Class ; rdfs:label "whole organism preparation" ; rdfs:subClassOf obo:OBI_0100051, [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:OBI_0100026 ] . obo:OBI_0000681 obo:IAO_0000111 "separation into different composition objective" ; obo:IAO_0000112 "The objective to obtain cells contained in a sample of blood." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A material separation objective aiming to separate a material entity that has parts of different types, and end with at least one output that is a material with parts of fewer types (modulo impurities)." ; obo:IAO_0000116 "We should be using has the grain relations or concentrations to distinguish the portioning and other sub-objectives" ; a owl:Class ; rdfs:label "separation into different composition objective" ; rdfs:subClassOf obo:OBI_0000639 . obo:OBI_0000682 obo:IAO_0000111 "obsolete_study result" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Study result is an information content entity that is a specified data output of a study." ; obo:IAO_0000119 "GROUP: OBI" ; obo:IAO_0000231 obo:IAO_0000230 ; a owl:Class ; rdfs:label "obsolete_study result" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000684 obo:IAO_0000111 "specimen collection objective" ; obo:IAO_0000112 "The objective to collect bits of excrement in the rainforest. The objective to obtain a blood sample from a patient." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A objective specification to obtain a material entity for potential use as an input during an investigation." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "Bjoern Peters" ; a owl:Class ; rdfs:label "specimen collection objective" ; rdfs:subClassOf obo:IAO_0000005 . obo:OBI_0000685 obo:IAO_0000111 "creating a mixture of molecules in solution" ; obo:IAO_0000112 "The production of PBS" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "is a process with the objective to prepare a liquid solution of one or more chemicals at desired concentrations." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "PERSON: Helen Parkinson" ; a owl:Class ; rdfs:label "creating a mixture of molecules in solution" ; rdfs:subClassOf obo:OBI_0000652, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:BFO_0000040 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0302729 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000686 ] . obo:OBI_0000686 obo:IAO_0000111 "material combination objective" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "is an objective to obtain an output material that contains several input materials." ; obo:IAO_0000117 "PPPB branch" ; obo:IAO_0000119 "bp" ; a owl:Class ; rdfs:label "material combination objective" ; rdfs:subClassOf obo:OBI_0000456 . obo:OBI_0000687 obo:IAO_0000111 "nucleotide overhang cloning" ; obo:IAO_0000112 "Cloning vectors are commercially available and supplied in linearized form with 3' dT overhangs" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Nucleotide overhang cloning is the process of inserting nucleic acid into a vector using nucleotide overhangs used to prevent self ligation" ; obo:IAO_0000117 "Helen Parkinson" ; a owl:Class ; rdfs:label "nucleotide overhang cloning" ; rdfs:subClassOf obo:OBI_0600064 . obo:OBI_0000688 obo:IAO_0000111 "rodent care protocol" ; obo:IAO_0000112 "Keeping mice in the UCSD animals facility at 20 - 25 degrees celsius, in cages of 4 animals each and providing food twice daily." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A rodent care protocol is an animal protocol in which the animals being taken care of are rodents." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "Bjoern Peters" ; a owl:Class ; rdfs:label "rodent care protocol" ; rdfs:subClassOf obo:OBI_0000715 . obo:OBI_0000689 obo:IAO_0000111 "454 Genome Sequence 20" ; obo:IAO_0000112 "PMID: 18946007.Pyrosequencing analysis of the oral microflora of healthy adults. Keijser BJ, Zaura E, Huse SM, van der Vossen JM, Schuren FH, Montijn RC, ten Cate JM, Crielaard W. J Dent Res. 2008 Nov;87(11):1016-20." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "is a DNA sequencer first manufactured by 454 Life Science Corporation in 2005, and enables pyrosequencing to be performed. It comprises both optics and fluidics subsystems, which are controlled by a computer subsystem. The fluidics subsystem ensures accurate reagent dispensing. It consists of a reagents cassette (which holds the reagent containers), a sipper manifold, pumps, valves, and debubblers. The fluidics subsystem flows the sequencing reagents across the wells of the PicoTiterPlate device, and moves the spent reagents from the PicoTiterPlate device to the waste receptacle. The optics subsystem consists of a CCD camera and a camera controller. The camera captures the light emitted in the wells of the PicoTiterPlate device during each step of the sequencing cycle, and sends the digital images to the computer subsystem for processing. The computer controls the other Sequencer subsystems, and processes the digital images sent by the camera to extract the DNA sequence information." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "GS 20" ; a owl:Class ; rdfs:label "454 Genome Sequence 20" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000758 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0000690 obo:IAO_0000111 "immunoprecipitation" ; obo:IAO_0000112 "PMID: 19419533. Arabidopsis RNA immunoprecipitation. Terzi LC, Simpson GG. Plant J. 2009 Jul;59(1):163-8." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is a process which realizes a material separation objective by relying on antibodies to specifically binding to material entity" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "OBI plan and planned process branch" ; a owl:Class ; rdfs:label "immunoprecipitation" ; rdfs:subClassOf obo:OBI_0600014, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:GO_0042571 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000639 ] . obo:OBI_0000691 obo:IAO_0000111 "ABI 377 automated sequencer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "is a DNA sequencer which is manufactured by Applied Biosystems corporation (formerly Perkin-Elmer). It allows automated chain termination DNA sequencing. It has part polyacrylamide gel electrophoresis system and a laser -based detection system to detect fluorescence intensity emitted by the dyes attached to the dideoxyterminator nucleotides or to the primers." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "Applied Biosystems" ; a owl:Class ; rdfs:label "ABI 377 automated sequencer" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000776 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0000692 obo:IAO_0000111 "recombination enzyme based cloning" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a recombination enzyme based cloning is a recombinant vector cloning process that uses complementary nucleotide sequences in both the insert genetic material and the cloning vector with a recombination enzyme to directly create a recombinant vector" ; a owl:Class ; rdfs:label "recombination enzyme based cloning" ; rdfs:subClassOf obo:OBI_0600064 . obo:OBI_0000693 obo:IAO_0000111 "MeDIP-seq assay" ; obo:IAO_0000112 "PMID: 18612301. A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Down TA, Rakyan VK, Turner DJ, Flicek P, Li H, Kulesha E, Gr�_f S, Johnson N, Herrero J, Tomazou EM, Thorne NP, B�_ckdahl L, Herberth M, Howe KL, Jackson DK, Miretti MM, Marioni JC, Birney E, Hubbard TJ, Durbin R, Tavar�� S, Beck S. Nat Biotechnol. 2008 Jul;26(7):779-85." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA methylation profiling assay that identifies methylated sites in genomic DNA and determines the methylation pattern that affect gene transcription using immunoprecipitation of methylated genomic DNA, creation of a library of corresponding DNA fragments (either single or paired-end fragments) and subsequent sequencing using parallelized sequencing methods." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "Methylated DNA immunoprecipitation sequencing assay" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Methylated_DNA_immunoprecipitation" ; a owl:Class ; rdfs:label "MeDIP-seq assay" ; rdfs:subClassOf obo:OBI_0000634, obo:OBI_0001954, obo:OBI_0600047, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400103 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000785 ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000785 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_00001975 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000711 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0003368 obo:OBI_0600047 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001051 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000973 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0044030 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001234 ] . obo:OBI_0000694 obo:IAO_0000111 "animal feeding" ; obo:IAO_0000112 "giving crickets to a snake." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "animal feeding is a process in which animals are provided with food" ; obo:IAO_0000116 "In an investigation, this will typically be part of an animal care process" ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "branch derived" ; a owl:Class ; rdfs:label "animal feeding" ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_0000248 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100026 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0100026 ] . obo:OBI_0000695 obo:IAO_0000111 "chain termination sequencing assay" ; obo:IAO_0000112 "PMID: 271968. DNA sequencing with chain-terminating inhibitors." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencing assay which rely on the use of dideoxynucleotides used in 4 distinct sequencing reaction on the same DNA sample. The dideoxynucleotides, once incorporated in the complementary DNA strand being synthesized by the DNA polymerase prevent any further chain elongation. The newly generated sequences are resolved on a polyacrylamide gel using electrophoresis and labels (either fluorochrome or radioactivity) are used to determine the nucleotide present at a given position" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "Sanger sequencing", "dye terminator sequencing" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Sanger_sequencing" ; a owl:Class ; rdfs:label "chain termination sequencing assay" ; rdfs:subClassOf obo:OBI_0000734, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0000691 obo:OBI_0000710 ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0000691 obo:OBI_0000710 ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000406 ] . obo:OBI_0000696 obo:IAO_0000111 "AB SOLiD System" ; obo:IAO_0000112 "PMID: 19336255. RNA-Seq-quantitative measurement of expression through massively parallel RNA-sequencing. Wilhelm BT, Landry JR. Methods. 2009 Jul;48(3):249-57." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "is a DNA sequencer which is manufactured by Applied Biosystems and which enable DNA sequencing by ligation" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "Applied Biosystems" ; a owl:Class ; rdfs:label "AB SOLiD System" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000776 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0000697 obo:IAO_0000111 "Helicos sequencing assay" ; obo:IAO_0000112 "PMID: 18388294. Single-molecule DNA sequencing of a viral genome." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencing by synthesis assay that identifiies the sequnece of billions of DNA molecules immobilized to a surface using DNA polymerase and fluorescently labeled nucleotides added one at a time. The sequencing process does not require an amplification step and is typically able to produce reads of 25 base pair length." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "true single molecule sequencing" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Helicos_single_molecule_fluorescent_sequencing" ; a owl:Class ; rdfs:label "Helicos sequencing assay" ; rdfs:subClassOf obo:OBI_0000734, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000717 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000717 ] ) ] . obo:OBI_0000698 obo:IAO_0000111 "obsolete_DNA ligase" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A DNA ligase is an enzyme that covalently joins two compatible pieces of DNA through the cleavage of an ATP molecule" ; obo:IAO_0000117 "Kevin Clancy, Bjoern Peters" ; obo:IAO_0000118 "ligase" ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:Class ; rdfs:label "obsolete_DNA ligase" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000699 obo:IAO_0000111 "survival assessment assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay that measures the occurrence of death events in one or more organisms over time" ; a owl:Class ; rdfs:label "survival assessment assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100026 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000789 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0100026 ] ] . obo:OBI_0000700 obo:IAO_0000111 "support vector machine" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A support vector machine is a data transformation with a class prediction objective based on the construction of a separating hyperplane that maximizes the margin between two data sets of vectors in n-dimensional space." ; obo:IAO_0000117 "James Malone", "Ryan Brinkman" ; obo:IAO_0000118 "SVM" ; obo:IAO_0000119 "PERSON: Ryan Brinkman" ; a owl:Class ; rdfs:label "support vector machine" ; rdfs:subClassOf obo:OBI_0000663, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200179 ] . obo:OBI_0000701 obo:IAO_0000111 "self-organizing map" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A self-organizing map (SOM) is an artificial neural network with objective class discovery that uses a neighborhood function to preserve the topological properties of a dataset to produce low-dimensional (typically 2) discretized representation of the training data set. A set of artificial neurons learn to map points in an input space to coordinates in an output space. The input space can have different dimensions and topology from the output space, and the SOM will attempt to preserve these." ; obo:IAO_0000117 "James Malone", "Ryan Brinkman" ; obo:IAO_0000118 "SOM" ; obo:IAO_0000119 "PERSON: Ryan Brinkman" ; a owl:Class ; rdfs:label "self-organizing map" ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200175, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0000648 obo:OBI_0000741 ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200178 ] ) ] . obo:OBI_0000702 obo:IAO_0000111 "454 Genome Sequencer FLX" ; obo:IAO_0000112 "PMID: 18616967. The Genome Sequencer FLX System--longer reads, more applications, straight forward bioinformatics and more complete data sets. Droege M, Hill B. J Biotechnol. 2008 Aug 31;136(1-2):3-10." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "is a DNA sequencer which was first manufactured by 454 Life Science Corporation in 2008 and enables pyrosequencing to be performed. It comprises both optics and fluidics subsystems, which are controlled by a computer subsystem. The fluidics subsystem ensures accurate reagent dispensing. It consists of a reagents cassette (which holds the reagent containers), a sipper manifold, pumps, valves, and debubblers. The fluidics subsystem flows the sequencing reagents across the wells of the PicoTiterPlate device, and moves the spent reagents from the PicoTiterPlate device to the waste receptacle. The optics subsystem consists of a CCD camera and a camera controller. The camera captures the light emitted in the wells of the PicoTiterPlate device during each step of the sequencing cycle, and sends the digital images to the computer subsystem for processing. The computer controls the other Sequencer subsystems, and processes the digital images sent by the camera to extract the DNA sequence information. It has the ability to sequence 400-600 million base pairs per run with 400-500 base pair read lengths." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "454 GS FLX", "GS-FLX" ; obo:IAO_0000119 "adapted from https://www.roche-applied-science.com/servlet/RCProductDisplay?langId=-1&storeId=10202&productId=3.8.8.1.1.3&catalogId=10202&krypto=mgV8a0Sdps6%2BCXU8IoddmzNEyGgjde9j8MOFCiMzRsduELeenAlVZ%2FE1QR%2BxLpzNlqMZPLRHqaI%3D&ddkey=https:RCProductDisplay" ; a owl:Class ; rdfs:label "454 Genome Sequencer FLX" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000758 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0000703 obo:IAO_0000111 "Illumina Genome Analyzer II" ; obo:IAO_0000112 "PMID: 19336255. RNA-Seq-quantitative measurement of expression through massively parallel RNA-sequencing. Wilhelm BT, Landry JR.Methods. 2009 Jul;48(3):249-57." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "is a DNA sequence which is manufactured by Illumina (Solexa) corporation. it support sequencing of single or paired end clone libraries relying on sequencing by synthesis technology" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "Illumina Corporation" ; a owl:Class ; rdfs:label "Illumina Genome Analyzer II" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000759 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0000704 obo:IAO_0000111 "decision tree induction objective" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A decision tree induction objective is a data transformation objective in which a tree-like graph of edges and nodes is created and from which the selection of each branch requires that some type of logical decision is made." ; obo:IAO_0000117 "James Malone" ; a owl:Class ; rdfs:label "decision tree induction objective" ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0000705 obo:IAO_0000111 "Edman degradation" ; obo:IAO_0000112 "Determination of the amino acid sequence of a peptide eluted from HLA-DRB1*04:01 to be VYPEVTVYPAKT." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A sequencing assay in which the amino acid sequence of input peptides or proteins is determined by iteratively cleaving of the amino-terminal (N-terminal) residue without disrupting the peptide bonds and identifying it by e.g. chromatography or electropheresis." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "Edman degradation" ; rdfs:subClassOf obo:OBI_0600047, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002743 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:BFO_0000040 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:BFO_0000040 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000030 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:SO_0000104 ] ] . obo:OBI_0000706 obo:IAO_0000111 "SOLiD sequencing assay" ; obo:IAO_0000112 "PMID: 19119315. High-resolution analysis of the 5'-end transcriptome using a next generation DNA sequencer. Hashimoto S, Qu W, Ahsan B, Ogoshi K, Sasaki A, Nakatani Y, Lee Y, Ogawa M, Ametani A, Suzuki Y, Sugano S, Lee CC, Nutter RC, Morishita S, Matsushima K. PLoS One. 2009;4(1):e4108." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencing by ligation assay that identifies sequence information using primers to hybridize to the P1 adapter sequence within the library template, fluorescently labeled di-base probes to compete for ligation to the sequencing primer, multiple cycles of ligation, detection and cleavage to determine the eventual read length, following a series of ligation cycles, the extension product is removed and the template is reset with a primer complementary to the n-1 position for a second round of ligation cycles." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/ABI_Solid_Sequencing" ; a owl:Class ; rdfs:label "SOLiD sequencing assay" ; rdfs:subClassOf obo:OBI_0000723, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000696 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000696 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0000722 obo:OBI_0000736 obo:PR_000023089 ) ] ] . obo:OBI_0000707 obo:IAO_0000111 "decision tree building data transformation"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A decision tree building data transformation is a data transformation that has objective decision tree induction."@en ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "PERSON: James Malone"@en ; a owl:Class ; rdfs:label "decision tree building data transformation"@en ; rdfs:subClassOf obo:OBI_0200000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000704 ] . obo:OBI_0000708 obo:IAO_0000111 "laboratory animal care" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a process that realizes an animal care protocol that specifies how animals are kept and maintained" ; a owl:Class ; rdfs:label "laboratory animal care" ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:BFO_0000029 ] ) ] ] ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000059 ; owl:someValuesFrom obo:OBI_0000715 ] ] . obo:OBI_0000709 obo:IAO_0000111 "yeast artificial chromosome vector" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a double-stranded DNA that was engineered to contain a yeast origin of replication, encodes for a selectable gene product, contains a cloning site, and has yeast telomerase sequences" ; obo:IAO_0000116 "this should be a child of 'chromosome' if we import that from another source" ; obo:IAO_0000117 "Kevin Clancy, Bjoern Peters" ; obo:IAO_0000118 "YAC" ; a owl:Class ; rdfs:label "yeast artificial chromosome vector" ; rdfs:subClassOf obo:CHEBI_4705, obo:OBI_0000737, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000411 ] . obo:OBI_0000710 obo:IAO_0000111 "Li-Cor 4300 DNA Analysis System" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "is a DNA sequencer which is manufactured by Li-Cor corporation and enable automated chain termination based DNA sequencing" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "OBI and Li-Cor" ; a owl:Class ; rdfs:label "Li-Cor 4300 DNA Analysis System" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000769 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0000711 obo:IAO_0000111 "library preparation" ; obo:IAO_0000112 "PMID: 19570239. Construction and analysis of cotton (Gossypium arboreum L.) drought-related cDNA library. Zhang L, Li FG, Liu CL, Zhang CJ, Zhang XY. BMC Res Notes. 2009 Jul 2;2:120." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "is a process which results in the creation of a library from fragments of DNA using cloning vectors or oligonucleotides with the role of adaptors." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "library construction" ; a owl:Class ; rdfs:label "library preparation" ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:CHEBI_16991 obo:CHEBI_4705 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0000164 obo:OBI_0000722 obo:OBI_0000736 obo:OBI_1000029 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0000712 obo:IAO_0000111 "pathogen challenge" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The administration of a live pathogenic organism to a host." ; a owl:Class ; rdfs:label "pathogen challenge" ; rdfs:subClassOf obo:OBI_0003456, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_0000725 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000319 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000718 ] ) ] ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000725 ] ) ] ] ) ] ] . obo:OBI_0000713 obo:IAO_0000111 "GenePattern software" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a software that provides access to more than 100 tools for gene expression analysis, proteomics, SNP analysis and common data processing tasks." ; obo:IAO_0000117 "James Malone", "Person:Helen Parkinson" ; obo:IAO_0000119 "WEB: http://www.broadinstitute.org/cancer/software/genepattern/" ; a owl:Class ; rdfs:label "GenePattern software" ; rdfs:subClassOf obo:IAO_0000010 . obo:OBI_0000714 obo:IAO_0000111 "graph of vertices" ; obo:IAO_0000112 "For example, if the nodes are cities, then the edges may have numerical values that correspond to the distances between the cities." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A construct that consists of many nodes connected with edges. The edges represent a relationship between the objects represented by the nodes. A graph can be equivalently represented as a matrix." ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert", "James Malone" ; obo:IAO_0000119 "WEB: http://mitpress.mit.edu/books/FLAOH/cbnhtml/glossary-G.html" ; a owl:Class ; rdfs:label "graph of vertices" ; rdfs:subClassOf obo:IAO_0000038 . obo:OBI_0000715 obo:IAO_0000111 "animal care protocol" ; obo:IAO_0000112 "Keeping mice in the UCSD animals facility at 20 - 25 degrees celsius, in cages of 4 animals each and providing food twice daily." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An animal care protocol is a protocol which specifies the environment in which animals are being kept in captivity for research purposes" ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "Bjoern Peters" ; a owl:Class ; rdfs:label "animal care protocol" ; rdfs:subClassOf obo:OBI_0000272 . obo:OBI_0000716 obo:IAO_0000111 "ChIP-seq assay" ; obo:IAO_0000112 "PMID: 19275939" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An assay in which chromatin is immunoprecipitated and subsequently analyzed using a DNA sequencing step to identify which parts of DNA are part of the isolated chromatin" ; obo:IAO_0000117 "Bjoern Peters", "Philippe Rocca-Serra" ; obo:IAO_0000118 "chromatin immunoprecipitation sequencing assay" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/ChIP-sequencing" ; a owl:Class ; rdfs:label "ChIP-seq assay" ; rdfs:subClassOf obo:OBI_0001954 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001954 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400103 ] ) ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000626 obo:OBI_0003368 ) ] ] ) ] . obo:OBI_0000717 obo:IAO_0000111 "HeliScope Single Molecule Sequencer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "is a DNA sequencer manufacturer by Helicos Corporation to carry out Single Molecule sequencing using reversible termination chemistry" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; a owl:Class ; rdfs:label "HeliScope Single Molecule Sequencer" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000757 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0000718 obo:IAO_0000111 "pathogen role" ; obo:IAO_0000112 "Pathogen: An agent of disease. A disease producer. The term pathogen most commonly is used to refer to infectious organisms. These include bacteria (such as staph), viruses (such as HIV), and fungi (such as yeast). Less commonly, pathogen refers to a noninfectious agent of disease such as a chemical. http://www.medterms.com/script/main/art.asp?articlekey=6383" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "pathogen role is a role which inheres in an organism and realized in the process of disease course in the organism bearing host role caused by the organism bearing pathogen role" ; obo:IAO_0000117 "GROUP: Role Branch" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000232 "6 April 2009: from the Vaccine Community" ; a owl:Class ; rdfs:label "pathogen role" ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0100026 ], [ a owl:Restriction ; owl:allValuesFrom obo:OGMS_0000063 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000719 obo:IAO_0000111 "vaccine preparation" ; obo:IAO_0000112 "The production of B. pertussis vaccine." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process with the objective to create a vaccine." ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "vaccine production" ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0000720 obo:IAO_0000111 "immunologic adjuvant role" ; obo:IAO_0000112 "Adjuvants are pharmacological or immunological agents that modify the effect of other agents (e.g., drugs, vaccines) while having few if any direct effects when given by themselves. http://en.wikipedia.org/wiki/Adjuvant" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The role a material entity plays when it is co-administered with an immunogen in order to enhance the immune response to the immunogen." ; obo:IAO_0000116 """11Feb09:Vaccine Ontology Definition: Adjuvant boosts immune response of a vaccine or antigen in the host. the role 'adjuvant role' inheres in some 'material entity' and is realized by some 'immune response assay'.""" ; obo:IAO_0000117 "GROUP: Role branch" ; obo:IAO_0000119 "Vaccine Ontology, Wikipedia, OBI" ; obo:IAO_0000232 "Renamed from adjuvent role, to be a more specific useage for immunology, tracker https://sourceforge.net/tracker/?func=detail&atid=886178&aid=2887909&group_id=177891" ; a owl:Class ; rdfs:comment "" ; rdfs:label "immunologic adjuvant role" ; rdfs:subClassOf obo:OBI_1110092, [ a owl:Restriction ; owl:allValuesFrom obo:GO_0006955 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000721 obo:IAO_0000111 "glucose tolerance test" ; obo:IAO_0000112 "PMID: 19527607" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An assay that measures glucose clearance from blood over time by repeated glucose measurement in blood serum or plasma after the administration of a glucose bolus in-vivo. This assay can be used to evaluate the severity of insulin resistance or the efficiency of glucose clearance." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "NuGO OBI plan branch" ; a owl:Class ; rdfs:label "glucose tolerance test" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0100017 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100017 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0600007 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000418 obo:OBI_0003368 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:HP_0000855 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000015 ] . obo:OBI_0000722 obo:IAO_0000111 "paired-end library" ; obo:IAO_0000112 "PMID: 19339662. Next-generation DNA sequencing of paired-end tags (PET) for transcriptome and genome analyses. Genome Res. 2009 Apr;19(4):521-32. Fullwood MJ, Wei CL, Liu ET, Ruan Y." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is a collection of short paired tags from the two ends of DNA fragments are extracted and covalently linked as ditag constructs" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "mate-paired library", "paired-end tag (PET) library" ; obo:IAO_0000119 "adapted from information provided by Solid web site" ; a owl:Class ; rdfs:label "paired-end library" ; rdfs:subClassOf obo:OBI_0000047 . obo:OBI_0000723 obo:IAO_0000111 "DNA sequencing by ligation assay" ; obo:IAO_0000112 "ABI Solid Sequencing uses the ligation-based DNA sequencing technology (https://en.wikipedia.org/wiki/ABI_Solid_Sequencing)." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A DNA sequencing assay that performs chain extension during the sequencing reaction step using DNA ligase" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Sequencing_by_ligation" ; a owl:Class ; rdfs:label "DNA sequencing by ligation assay" ; rdfs:subClassOf obo:OBI_0000626, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000023089 ] . obo:OBI_0000724 obo:IAO_0000111 "Solexa sequencing assay" ; obo:IAO_0000112 "PMID: 18987734" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencing by synthesis assay that identifies sequence information using DNA polymerase and reversible terminator, requiring immobilization of genomic DNA fragments onto a surface and a specific clonal amplification step known as bridge PCR. Reliance on a reversible terminator allows cycles of DNA chain extension by DNA polymerase and imaging without the need of electrophoretic separation of newly synthesized DNA fragment as with Sanger sequencing." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "reversible terminator sequencing" ; obo:IAO_0000119 "Solexa web site (SS_DNAsequencing.pdf document available on july 2009)" ; a owl:Class ; rdfs:label "Solexa sequencing assay" ; rdfs:subClassOf obo:OBI_0000734, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000703 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000703 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0000722 obo:OBI_0000736 ) ] ] . obo:OBI_0000725 obo:IAO_0000111 "host role" ; obo:IAO_0000112 "In biology, a host is an organism that harbors a virus or parasite, or a mutual or commensal symbiont, typically providing nourishment and shelter. http://en.wikipedia.org/wiki/Host_(biology) 30 March 09" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "host role is a role played by an organism and realized by providing nourishment, shelter or a means of reproduction to another organism within the organism playing the host role" ; obo:IAO_0000116 "30Mar09 virus reproducing inside a cell; bacteria causing a disease, host can be harmed or not. we want to avoid a cat sitting on my lap and an animal care technician; these are not examples or hosts; dental cares = on tooth, but part of outer layer of tooth, so covered by \"within\" in the definition" ; obo:IAO_0000117 "GROUP: Role Branch" ; obo:IAO_0000119 "30 Mar09 submitted by vaccine community", "OBI", "http://en.wikipedia.org/wiki/Host_(biology)" ; a owl:Class ; rdfs:label "host role" ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0100026 ] . obo:OBI_0000726 obo:IAO_0000111 "peak matching" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Peak matching is a data transformation performed on a dataset of a graph of ordered data points (e.g. a spectrum) with the objective of pattern matching local maxima above a noise threshold" ; obo:IAO_0000117 "James Malone", "Ryan Brinkman" ; obo:IAO_0000119 "PERSON: Ryan Brinkman" ; a owl:Class ; rdfs:label "peak matching" ; rdfs:subClassOf obo:OBI_0200000 . obo:OBI_0000727 obo:IAO_0000111 "k-nearest neighbors"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A k-nearest neighbors is a data transformation which achieves a class discovery or partitioning objective, in which an input data object with vector y is assigned to a class label based upon the k closest training data set points to y; where k is the largest value that class label is assigned."@en ; obo:IAO_0000117 "James Malone"@en ; obo:IAO_0000118 "k-NN" ; obo:IAO_0000119 "PERSON: James Malone"@en ; a owl:Class ; rdfs:label "k-nearest neighbors"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200171, obo:OBI_0200175, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000648 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200178 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200172 ] . obo:OBI_0000728 obo:IAO_0000111 "rodent care" ; obo:IAO_0000112 "keeping animal" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "rodent care is the process by which rodents are being provided with a controlled living environment while kept in captivity for the purpose of research." ; obo:IAO_0000117 "PPPB branch" ; obo:IAO_0000119 "PPPB branch" ; a owl:Class ; rdfs:label "rodent care" ; rdfs:subClassOf obo:OBI_0000708, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000694 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000370 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400171 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000059 ; owl:someValuesFrom obo:OBI_0000688 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:NCBITaxon_9989 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:NCBITaxon_9989 ] . obo:OBI_0000729 obo:IAO_0000111 "cloning plasmid" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cloning plasmid is a plasmid that was engineered to contain a bacterial origin of replication, encodes for a selectable gene product and contains a cloning site." ; obo:IAO_0000116 "Note: 'cloning vector role' is really a function. Should be dealt with globally" ; a owl:Class ; rdfs:label "cloning plasmid" ; rdfs:subClassOf obo:OBI_0000430, obo:OBI_0000737 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000430 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000411 ] ) ] . obo:OBI_0000730 obo:IAO_0000111 "pyrosequencing assay" ; obo:IAO_0000112 "Pyrosequencing sheds light on DNA sequencing. PMID:1115661" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencing by synthesis assay which sequences a single strand of DNA by synthesizing the complementary strand along it, one base pair at a time, and detecting which base was actually added at each step. The template DNA is immobilized, and solutions of A, C, G, and T nucleotides are added and removed after the reaction, sequentially. Light is produced only when the nucleotide solution complements the first unpaired base of the template. The sequence of solutions which produce chemiluminescent signals allows the determination of the sequence of the template. ssDNA template is hybridized to a sequencing primer and incubated with the enzymes DNA polymerase, ATP sulfurylase, luciferase and apyrase, and with the substrates adenosine 5-prime phosphosulfate (APS) and luciferin." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "url:http://en.wikipedia.org/wiki/Pyrosequencing" ; a owl:Class ; rdfs:label "pyrosequencing assay" ; rdfs:subClassOf obo:OBI_0000734, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0000689 obo:OBI_0000702 ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0000689 obo:OBI_0000702 ) ] ] ) ] . obo:OBI_0000731 obo:IAO_0000111 "recombinant vector" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A recombinant vector is created by a recombinant vector cloning process, and contains nucleic acids that can be amplified. It retains functions of the original cloning vector." ; a owl:Class ; rdfs:label "recombinant vector" ; rdfs:subClassOf obo:OBI_0000047 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600064 ] ) ] . obo:OBI_0000732 obo:IAO_0000111 "restriction enzyme" ; obo:IAO_0000112 "The enzyme EcoR1 cuts DNA at the canonical cleavage site CAATTG" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "an enzyme that has a specific target cleavage sites within nucleic acids" ; obo:IAO_0000117 "Kevin Clancy, Bjoern Peters" ; obo:IAO_0000232 "5/22 Need to explore if there are GO / other classes exist that capture this. We need it now for cloning experiments" ; a owl:Class ; rdfs:label "restriction enzyme" ; rdfs:subClassOf obo:PR_000000001, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0003824 ] . obo:OBI_0000734 obo:IAO_0000111 "DNA sequencing by synthesis assay" ; obo:IAO_0000112 "Roche-454 pyrosequencing and Illumina (Solexa) sequencing use synthesis-based method for DNA sequencing" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A DNA sequencing assay that relies on DNA polymerase activity to perform chain extension during the sequencing reaction step." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "url:https://www.illumina.com/technology/next-generation-sequencing/sequencing-technology.html" ; a owl:Class ; rdfs:label "DNA sequencing by synthesis assay" ; rdfs:subClassOf obo:OBI_0000626, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:GO_0042575 ] . obo:OBI_0000735 obo:IAO_0000111 "NTP-2000" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a material consisting of 14.5% protein, 8.5% fat and 9.5% fiber produced to feed rodents" ; obo:IAO_0000117 "Jennifer Fostel, Bjoern Peters" ; a owl:Class ; rdfs:label "NTP-2000" ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000457 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000248 ] . obo:OBI_0000736 obo:IAO_0000111 "single fragment library" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is a collection of short tags from DNA fragments, are extracted and covalently linked as single tag constructs" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "fragment library" ; a owl:Class ; rdfs:label "single fragment library" ; rdfs:subClassOf obo:OBI_0000047 . obo:OBI_0000737 obo:IAO_0000111 "cloning vector" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cloning vector is an engineered material that is used as an input material for a recombinant vector cloning process to carry inserted nucleic acids. It contains an origin of replication for a specific destination host organism, encodes for a selectable gene product and contains a cloning site." ; a owl:Class ; rdfs:label "cloning vector" ; rdfs:subClassOf obo:OBI_0000047, obo:OBI_1110108, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000094 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000411 ] ) ] . obo:OBI_0000738 obo:IAO_0000111 "restriction enzyme based cloning" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "restriction enzyme based cloning is a recombinant vector cloning process that has as an input genetic material that was cleaved with restriction enzymes, and a cloning vector that was cleaved with complementary restriction enzymes. It uses ligase to chemically join the input genetic material and the cloning vector to create a recombinant vector." ; obo:IAO_0000117 "Kevin Clancy, Bjoern Peters" ; a owl:Class ; rdfs:label "restriction enzyme based cloning" ; rdfs:subClassOf obo:OBI_0600064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0302892 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000411 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000742 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000416 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000742 ] ) ] ] . obo:OBI_0000739 obo:IAO_0000111 "Student's t-test" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Studen't t-test is a data transformation with the objective of a statistical hypothesis test in which the test statistic has a Student's t distribution if the null hypothesis is true. It is applied when the population is assumed to be normally distributed but the sample sizes are small enough that the statistic on which inference is based is not normally distributed because it relies on an uncertain estimate of standard deviation rather than on a precisely known value." ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/T-test" ; a owl:Class ; rdfs:label "Student's t-test" ; rdfs:subClassOf obo:OBI_0000673, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000175 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000675 ] . obo:OBI_0000740 obo:IAO_0000111 "material sample role" ; obo:IAO_0000112 "a role borne by a portion of blood taken to represent all the blood in an organism; the role borne by a population of humans with HIV enrolled in a study taken to represent patients with HIV in general." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A material sample role is a specimen role borne by a material entity that is the output of a material sampling process." ; obo:IAO_0000116 "7/13/09: Note that this is a relational role: between the sample taken and the 'sampled' material of which the sample is thought to be representative off." ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "material sample role" ; rdfs:subClassOf obo:OBI_0000112 . obo:OBI_0000741 obo:IAO_0000111 "topologically preserved clustered data set" ; obo:IAO_0000112 "the output data set generated from a self-organizing map." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A clustered data set in which the topology, i.e. the spatial properties between data points, is preserved from the original input data from which it was derived." ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "PERSON: James Malone" ; a owl:Class ; rdfs:label "topologically preserved clustered data set" ; rdfs:subClassOf obo:OBI_0000648 . obo:OBI_0000742 obo:IAO_0000111 "nucleic acid restriction enzyme digest" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A nucleic acid digest is a material that is the output of a process in which nucleic acids are combined with a restriction enzyme resulting in digested fragments with defined ends based on the enzymes cleavage site" ; obo:IAO_0000117 "Kevin Clancy, Bjoern Peters" ; a owl:Class ; rdfs:label "nucleic acid restriction enzyme digest" ; rdfs:subClassOf obo:CHEBI_33696, obo:OBI_0000047 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33696 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0600050 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33696 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom obo:OBI_0000732 ] ) ] ] ) ] . obo:OBI_0000743 obo:IAO_0000111 "immune response assay" ; obo:IAO_0000112 "Measuring if a Hepacivirus C (HCV) infected patient has an antibody response to HCV core protein by ELISA." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay that determines information about an immune response" ; obo:IAO_0000117 "Bjoern Peters", "Randi Vita" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "immune response assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0006955 ] ] . obo:OBI_0000744 obo:IAO_0000111 "material sampling process" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A specimen gathering process with the objective to obtain a specimen that is representative of the input material entity" ; obo:IAO_0000118 "sample collection", "sampling" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1002" ; a owl:Class ; rdfs:label "material sampling process" ; rdfs:subClassOf obo:OBI_0000659 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:BFO_0000040 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000747 ] ) ] . obo:OBI_0000747 obo:IAO_0000111 "material sample" ; obo:IAO_0000112 "blood drawn from patient to measure his systemic glucose level. A population of humans with HIV enrolled in a study taken to represent patients with HIV in general." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A material entity that has the material sample role" ; obo:IAO_0000117 "OBI: workshop" ; obo:IAO_0000118 "sample population" ; obo:IAO_0000233 ; obo:OBI_0001847 "sample" ; a owl:Class ; rdfs:label "material sample" ; rdfs:subClassOf obo:OBI_0100051 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000740 ] ) ] . obo:OBI_0000748 obo:IAO_0000111 "bisulfite sequencing assay" ; obo:IAO_0000112 "PMID: 19581485. High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. Hodges E, Smith A, Kendall J, Xuan Z, Ravi K, Rooks M, Zhang M, Ye K, Battacharjee A, Brizuela L, McCombie WR, Wigler M, Hannon GJ, Hicks J." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA methylation profiling assay which determines the methylation status of genomic DNA using DNA sequencing techniques preceded by a bisulfite based chemical modification of genomic DNA at CpG island location." ; obo:IAO_0000117 "Philippe Rocca-Serra", "Sagar Jain" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Bisulfite_sequencing" ; a owl:Class ; rdfs:label "bisulfite sequencing assay" ; rdfs:subClassOf obo:OBI_0000626, obo:OBI_0000634, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400103 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000626 obo:OBI_0003368 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001051 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:IAO_0000109 obo:OBI_0001573 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0044030 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001234 ] . obo:OBI_0000749 obo:IAO_0000111 "CART"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A CART (classification and regression trees) is a data transformation method for producing a classification or regression model with a tree-based structure."@en ; obo:IAO_0000117 "James Malone"@en ; obo:IAO_0000118 "classification and regression trees" ; obo:IAO_0000119 "BOOK: David J. Hand, Heikki Mannila and Padhraic Smyth (2001) Principles of Data Mining."@en ; a owl:Class ; rdfs:label "CART"@en ; rdfs:subClassOf obo:OBI_0000707, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000704 ] . obo:OBI_0000750 obo:IAO_0000111 "independent variable specification" ; obo:IAO_0000112 "In a study in which gene expression is measured in patients between 8 month to 4 years old that have mild or severe malaria and in which the hypothesis is that gene expression in that age group is a function of disease status, disease status is the independent variable." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "a directive information entity that is part of a study design. Independent variables are entities whose values are selected to determine its relationship to an observed phenomenon (the dependent variable). In such an experiment, an attempt is made to find evidence that the values of the independent variable determine the values of the dependent variable (that which is being measured). The independent variable can be changed as required, and its values do not represent a problem requiring explanation in an analysis, but are taken simply as given. The dependent variable on the other hand, usually cannot be directly controlled"@en ; obo:IAO_0000116 "2/2/2009 Original definition - In the design of experiments, independent variables are those whose values are controlled or selected by the person experimenting (experimenter) to determine its relationship to an observed phenomenon (the dependent variable). In such an experiment, an attempt is made to find evidence that the values of the independent variable determine the values of the dependent variable (that which is being measured). The independent variable can be changed as required, and its values do not represent a problem requiring explanation in an analysis, but are taken simply as given. The dependent variable on the other hand, usually cannot be directly controlled."@en, "In the Philly 2013 workshop the label was chosen to distinguish it from \"dependent variable\" as used in statistical modelling. See: http://en.wikipedia.org/wiki/Statistical_modeling" ; obo:IAO_0000117 "PERSON: Alan Ruttenberg", "PERSON: Bjoern Peters", "PERSON: Chris Stoeckert" ; obo:IAO_0000118 "experimental factor", "independent variable" ; obo:IAO_0000119 "Web: http://en.wikipedia.org/wiki/Dependent_and_independent_variables" ; obo:IAO_0000232 "2009-03-16: work has been done on this term during during the OBI workshop winter 2009 and the current definition was considered acceptable for use in OBI. If there is a need to modify thisdefinition please notify OBI." ; obo:OBI_0001847 "study factor" ; a owl:Class ; rdfs:label "study design independent variable"@en ; rdfs:subClassOf obo:IAO_0000033, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0500000 ] . obo:OBI_0000751 obo:IAO_0000111 "dependent variable specification" ; obo:IAO_0000112 "In a study in which gene expression is measured in patients between 8 month to 4 years old that have mild or severe malaria and in which the hypothesis is that gene expression in that age group is a function of disease status, the gene expression is the dependent variable." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "dependent variable specification is part of a study design. The dependent variable is the event studied and expected to change when the independent variable varies."@en ; obo:IAO_0000116 "2/2/2009 In the design of experiments, independent variables are those whose values are controlled or selected by the person experimenting (experimenter) to determine its relationship to an observed phenomenon (the dependent variable). In such an experiment, an attempt is made to find evidence that the values of the independent variable determine the values of the dependent variable (that which is being measured). The independent variable can be changed as required, and its values do not represent a problem requiring explanation in an analysis, but are taken simply as given. The dependent variable on the other hand, usually cannot be directly controlled."@en, "In the Philly 2013 workshop the label was chosen to distinguish it from \"dependent variable\" as used in statistical modelling. See: http://en.wikipedia.org/wiki/Statistical_modeling" ; obo:IAO_0000117 "PERSON: Alan Ruttenberg", "PERSON: Bjoern Peters", "PERSON: Chris Stoeckert" ; obo:IAO_0000118 "dependent variable" ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Dependent_and_independent_variables" ; obo:IAO_0000232 "2009-03-16: work has been done on this term during during the OBI workshop winter 2009 and the current definition was considered acceptable for use in OBI. If there is a need to modify thisdefinition please notify OBI." ; a owl:Class ; rdfs:label "study design dependent variable"@en ; rdfs:subClassOf obo:IAO_0000033, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0500000 ] . obo:OBI_0000752 obo:IAO_0000111 "Thermo" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Philippe Rocca-Serra" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Thermo" . obo:OBI_0000753 obo:IAO_0000111 "Waters" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Philippe Rocca-Serra" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Waters" . obo:OBI_0000754 obo:IAO_0000111 "BIO-RAD" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Philippe Rocca-Serra" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "BIO-RAD" . obo:OBI_0000755 obo:IAO_0000111 "GenePattern hierarchical clustering" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "James Malone" ; a obo:OBI_0200042, owl:NamedIndividual ; rdfs:label "GenePattern hierarchical clustering" . obo:OBI_0000756 obo:IAO_0000111 "Ambion" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Philippe Rocca-Serra" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Ambion" . obo:OBI_0000757 obo:IAO_0000111 "Helicos" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Philippe Rocca-Serra" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Helicos" . obo:OBI_0000758 obo:IAO_0000111 "Roche" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Philippe Rocca-Serra" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Roche" . obo:OBI_0000759 obo:IAO_0000111 "Illumina" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Philippe Rocca-Serra" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Illumina" . obo:OBI_0000760 obo:IAO_0000111 "GenePattern PCA" ; obo:IAO_0000114 obo:IAO_0000123 ; a obo:OBI_0200051, owl:NamedIndividual ; rdfs:label "GenePattern PCA" . obo:OBI_0000761 obo:IAO_0000111 "GenePattern module SVM" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "GenePattern module SVM is a GenePattern software module which is used to run a support vector machine data transformation." ; obo:IAO_0000117 "James Malone", "Ryan Brinkman" ; obo:IAO_0000136 obo:OBI_0000775 ; a obo:OBI_0000713, owl:NamedIndividual ; rdfs:label "GenePattern module SVM" . obo:OBI_0000762 obo:IAO_0000111 "GenePattern k-nearest neighbors" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "James Malone" ; a obo:OBI_0000727, owl:NamedIndividual ; rdfs:label "GenePattern k-nearest neighbors" . obo:OBI_0000763 obo:IAO_0000111 "GenePattern LOOCV" ; obo:IAO_0000114 obo:IAO_0000123 ; a obo:OBI_0200033, owl:NamedIndividual ; rdfs:label "GenePattern LOOCV" . obo:OBI_0000764 obo:IAO_0000111 "GenePattern k-means clustering" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "James Malone" ; a obo:OBI_0200041, owl:NamedIndividual ; rdfs:label "GenePattern k-means clustering" . obo:OBI_0000765 obo:IAO_0000111 "Agilent" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Philippe Rocca-Serra" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Agilent" . obo:OBI_0000766 obo:IAO_0000111 "GenePattern module KMeansClustering" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "GenePattern module KMeansClustering is a GenePattern software module which is used to perform a k Means clustering data transformation." ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "PERSON: James Malone" ; obo:IAO_0000136 obo:OBI_0000764 ; a obo:OBI_0000713, owl:NamedIndividual ; rdfs:label "GenePattern module KMeansClustering" . obo:OBI_0000767 obo:IAO_0000111 "GenePattern CART" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "James Malone" ; a obo:OBI_0000749, owl:NamedIndividual ; rdfs:label "GenePattern CART" . obo:OBI_0000768 obo:IAO_0000111 "GenePattern module CARTXValidation" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "GenePattern module CARTXValidation is a GenePattern software module which uses a CART decision tree induction with a leave one out cross validation data transformations." ; obo:IAO_0000136 obo:OBI_0000763, obo:OBI_0000767 ; a obo:OBI_0000713, owl:NamedIndividual ; rdfs:label "GenePattern module CARTXValidation" . obo:OBI_0000769 obo:IAO_0000111 "Li-Cor" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Philippe Rocca-Serra" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Li-Cor" . obo:OBI_0000770 obo:IAO_0000111 "Bruker Corporation" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Philippe Rocca-Serra" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Bruker Corporation" . obo:OBI_0000771 obo:IAO_0000111 "GenePattern module KNNXValidation" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "GenePattern module KNNXValidation is a GenePattern software module which uses a k-nearest neighbours clustering with a leave one out cross validation data transformations." ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "PERSON: James Malone" ; a obo:OBI_0000713, owl:NamedIndividual ; rdfs:label "GenePattern module KNNXValidation" . obo:OBI_0000772 obo:IAO_0000111 "GenePattern module PeakMatch" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000136 obo:OBI_0000778 ; a obo:OBI_0000713, owl:NamedIndividual ; rdfs:label "GenePattern module PeakMatch" . obo:OBI_0000773 obo:IAO_0000111 "GenePattern module KNN" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "GenePattern module KNN is a GenePattern software module which perform a k-nearest neighbors data transformation." ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000136 obo:OBI_0000762 ; a obo:OBI_0000713, owl:NamedIndividual ; rdfs:label "GenePattern module KNN" . obo:OBI_0000774 obo:IAO_0000111 "GenePattern module HierarchicalClustering" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "GenePattern module HierarchicalClustering is a GenePattern software module which is used to perform a hierarchical clustering data transformation." ; obo:IAO_0000117 "James Malone", "PERSON: James Malone" ; obo:IAO_0000136 obo:OBI_0000755 ; a obo:OBI_0000713, owl:NamedIndividual ; rdfs:label "GenePattern module HierarchicalClustering" . obo:OBI_0000775 obo:IAO_0000111 "GenePattern SVM" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "James Malone" ; a obo:OBI_0000700, owl:NamedIndividual ; rdfs:label "GenePattern SVM" . obo:OBI_0000776 obo:IAO_0000111 "Applied Biosystems" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Philippe Rocca-Serra" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Applied Biosystems" . obo:OBI_0000777 obo:IAO_0000111 "GenePattern module PCA" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "GenePattern module PCA is a GenePattern software module which is used to perform a principal components analysis dimensionality reduction data transformation." ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "PERSON: James Malone" ; obo:IAO_0000136 obo:OBI_0000760 ; a obo:OBI_0000713, owl:NamedIndividual ; rdfs:label "GenePattern module PCA" . obo:OBI_0000778 obo:IAO_0000111 "GenePattern peak matching" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "James Malone", "Ryan Brinkman" ; a obo:OBI_0000726, owl:NamedIndividual ; rdfs:label "GenePattern peak matching" . obo:OBI_0000779 obo:IAO_0000111 "Bruker Daltonics" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Philippe Rocca-Serra" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Bruker Daltonics" . obo:OBI_0000780 obo:IAO_0000111 "GenePattern HeatMapViewer data visualization" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The GenePattern process of generating Heat Maps from clustered data." ; obo:IAO_0000117 "James Malone" ; a obo:OBI_0200190, owl:NamedIndividual ; rdfs:label "GenePattern HeatMapViewer data visualization" . obo:OBI_0000781 obo:IAO_0000111 "GenePattern HierarchicalClusteringViewer data visualization" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The GenePattern process of generating hierarchical clustering visualization from clustered data." ; obo:IAO_0000117 "James Malone" ; a obo:OBI_0200190, owl:NamedIndividual ; rdfs:label "GenePattern HierarchicalClusteringViewer data visualization" . obo:OBI_0000782 obo:IAO_0000111 "GenePattern module HeatMapViewer" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A GenePattern software module which is used to generate a heatmap view of data." ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000136 obo:OBI_0000780 ; a obo:OBI_0000713, owl:NamedIndividual ; rdfs:label "GenePattern module HeatMapViewer" . obo:OBI_0000783 obo:IAO_0000111 "GenePattern module HierarchicalClusteringViewer" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A GenePattern software module which is used to generate a view of data that has been hierarchically clustered." ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000136 obo:OBI_0000781 ; a obo:OBI_0000713, owl:NamedIndividual ; rdfs:label "GenePattern module HierarchicalClusteringViewer" . obo:OBI_0000784 obo:IAO_0000111 "anticoagulant-containing test tube" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A 'blue top' test tube that contains anticoagulant for storing blood specimens'" ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "anticoagulant-containing test tube" ; rdfs:subClassOf obo:OBI_0000836, [ a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:CHEBI_32142 ] ] ] . obo:OBI_0000785 obo:IAO_0000111 "controlled variable specification" ; obo:IAO_0000112 "In a study in which gene expression is measured in patients between 8 month to 4 years old that have mild or severe malaria and in which the hypothesis is that gene expression in that age group is a function of disease status, age is a controlled variable." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "Controlled variable specification is a part of a study design. They are the entities that could vary, but are kept constant to prevent their influence on the effect of the independent variable on the dependent."@en ; obo:IAO_0000116 "2/2/2009 Original definition: Controlled variables are also important to identify in experiments. They are the variables that are kept constant to prevent their influence on the effect of the independent variable on the dependent. Every experiment has a controlling variable, and it is necessary to not change it, or the results of the experiment won't be valid"@en, "In the Philly 2013 workshop the label was chosen to distinguish it from \"controlled variable\" as used in statistical modelling" ; obo:IAO_0000117 "PERSON: Alan Ruttenberg", "PERSON: Bjoern Peters", "PERSON: Chris Stoeckert" ; obo:IAO_0000118 "controlled variable" ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Control_variable" ; obo:IAO_0000232 "2009-03-16: work has been done on this term during during the OBI workshop winter 2009 and the current definition was considered acceptable for use in OBI. If there is a need to modify thisdefinition please notify OBI." ; a owl:Class ; rdfs:label "study design controlled variable"@en ; rdfs:subClassOf obo:IAO_0000033, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0500000 ] . obo:OBI_0000787 obo:IAO_0000111 "human antithrombin-III in blood assay" ; obo:IAO_0000112 "PMID:19696660#The antithrombin-III (AT-III) was determined using a Berichrom(r) Antithrombin-III (A) kit." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An assay that measures the amount of antithrombin III in blood." ; obo:IAO_0000117 "Alan Ruttenberg" ; obo:IAO_0000118 "AT-III assay" ; obo:IAO_0000119 "url:http://www.muschealth.com/lab/content.aspx?id=150006@2009/08/06" ; a owl:Class ; rdfs:label "human antithrombin-III in blood assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000576 [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:PR_000003252 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000576 [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:PR_000003252 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000032 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0007596 ] ] . obo:OBI_0000788 obo:IAO_0000111 "fluorescently labeled MHC multimer" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A complex of two or more linked MHC molecules including a fluorescent label that can be loaded with a ligand, and is used in flow cytometry assay to bind to T cell receptors of T cells specific for the ligand" ; a owl:Class ; rdfs:label "fluorescently labeled MHC multimer" ; rdfs:subClassOf obo:OBI_0001936, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0002744 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600038 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000018 ] . obo:OBI_0000789 obo:IAO_0000111 "survival rate" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A measurement data that represents the percentage of people or animals in a study or treatment group who are alive for a given period of time after diagnosis or initiation of monitoring." ; obo:IAO_0000117 "Oliver He" ; obo:IAO_0000119 """adapted from wikipedia http://en.wikipedia.org/wiki/Survival_rate""" ; a owl:Class ; rdfs:label "survival rate" ; rdfs:subClassOf obo:IAO_0000109 . obo:OBI_0000790 obo:IAO_0000111 "recombinant BAC cloning" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Recombinant BAC cloning is a process with the objective to insert genetic material into an F plasmid based bacterial artificial chromosome for future replication of the inserted material" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Bacterial_artificial_chromosome" ; a owl:Class ; rdfs:label "recombinant BAC cloning" ; rdfs:subClassOf obo:OBI_0600064 . obo:OBI_0000791 obo:IAO_0000111 "multiple testing correction objective" ; obo:IAO_0000112 "Application of the Bonferroni correction" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A multiple testing correction objectives is a data transformation objective where the aim is to correct for a set of statistical inferences considered simultaneously" ; obo:IAO_0000118 "multiple comparison correction objective" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Multiple_Testing_Correction" ; a owl:Class ; rdfs:label "multiple testing correction objective" ; rdfs:subClassOf obo:OBI_0200186 . obo:OBI_0000792 obo:IAO_0000111 "statistical model validation" ; obo:IAO_0000112 "Using the expression levels of 20 proteins to predict whether a cancer patient will respond to a drug. A practical goal would be to determine which subset of the 20 features should be used to produce the best predictive model. - wikipedia" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data transformation which assesses how the results of a statistical analysis will generalize to an independent data set." ; obo:IAO_0000117 "Helen Parkinson" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Cross-validation_%28statistics%29" ; a owl:Class ; rdfs:label "statistical model validation" ; rdfs:subClassOf obo:OBI_0200171 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200188 ] . obo:OBI_0000793 obo:IAO_0000111 "double blind study execution" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A double blind study execution is defined as any study execution in which neither the subjects nor the investigators are informed of which study arm the subjects are part of during the portion of the trial when the subjects are being treated" ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000119 "http://clinicaltrials.gov/ct2/info/glossary#double" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "double blind study execution" ; rdfs:subClassOf obo:OBI_0000822 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000826 [ a owl:Restriction ; owl:allValuesFrom [ a owl:Class ; owl:complementOf [ a owl:Class ; owl:unionOf (obo:OBI_0000804 obo:OBI_0000842 ) ] ] ; owl:onProperty obo:BFO_0000051 ] ) ] . obo:OBI_0000794 obo:IAO_0000111 "obsolete transcription factor binding site" ; obo:IAO_0000114 obo:IAO_0000002 ; obo:IAO_0000119 "SO:0000235" ; obo:IAO_0000231 obo:IAO_0000228 ; obo:IAO_0000232 "PLace_holder for sequence ontology term" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1553" ; obo:IAO_0100001 obo:SO_0000235 ; a owl:Class ; rdfs:label "obsolete transcription factor binding site" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000795 obo:IAO_0000111 "glucometer" ; obo:IAO_0000112 "Diabetic patients use glucometers to determine their glucose levels" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A measurement device with the function to measure and record the level/amount of glucose in a blood sample" ; obo:IAO_0000117 "PERSON:Frank Gibson", "PERSON:Helen Parkinson" ; obo:IAO_0000118 "glucose meter" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Glucose_meter" ; a owl:Class ; rdfs:label "glucometer" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000796 obo:IAO_0000111 "purification objective" ; obo:IAO_0000112 "the objective to obtain a pure fraction of a specific peptide when running an HPLC on a crude synthesis of peptides." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The objective to separate a material entity into different compositions of which one or more have are purified fractions that contain higher concentration of a desired component, while others contain impurities and are not of interest" ; obo:IAO_0000117 "PERSON:Bjoern Peters" ; obo:IAO_0000118 "isolation objective" ; obo:IAO_0000119 "BP" ; obo:IAO_0000232 "10/14/09, BP: This should be linked to the 'purified' 'currently conferred quality" ; a owl:Class ; rdfs:label "purification objective" ; rdfs:subClassOf obo:OBI_0000681 . obo:OBI_0000797 obo:IAO_0000111 "obsolete_primary structure of protein" ; obo:IAO_0000112 "SIINFEKL' is the primary structure of a peptide" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The primary structure of a protein that is completely defined by the set of its amino acid residue parts and the linear order induced by the peptide bonds that hold them together" ; obo:IAO_0000117 "Person:Bjoern Peters" ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:Class ; rdfs:label "obsolete_primary structure of protein" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000798 obo:IAO_0000111 "capsule shell" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a small rounded gelatinous container" ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000119 "http://www.golovchenko.org/cgi-bin/wnsearch?q=capsule#2n" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "capsule shell" ; rdfs:subClassOf obo:BFO_0000040 . obo:OBI_0000799 obo:IAO_0000111 "recombinant phage cloning" ; obo:IAO_0000112 "Insert selection by BamHI methyltransferase protection in P1 phage-based cloning" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Recombinant phage cloning is the process of using a phage plus some insert nucleic acid for the purposes of amplification of the insert material achieved by phage assembly in vitro." ; obo:IAO_0000117 "Helen Parkinson" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mcb.section.1611" ; a owl:Class ; rdfs:label "recombinant phage cloning" ; rdfs:subClassOf obo:OBI_0600064 . obo:OBI_0000800 obo:IAO_0000111 "cross linking" ; obo:IAO_0000112 "cross linking can be used as a probe to link proteins together, to check protein protein interactions" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A process in which bonds are created that link one polymer to another" ; obo:IAO_0000117 "PERSON: Chris Stoeckert" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Cross-link" ; a owl:Class ; rdfs:label "cross linking" ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:CHEBI_23367 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0000801 obo:IAO_0000111 "spike train datum" ; obo:IAO_0000112 "Measurement of temporal regularity of spike train responses in auditory nerve fibers of the green treefrog" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A measurement datum which represents information about an ordered series of action potentials in an organism's CNS measured over time." ; obo:IAO_0000116 "needs more work to see exactly what the data set looks like - HP" ; obo:IAO_0000117 "Helen Parkinson, Alan Ruttenberg" ; obo:IAO_0000118 "spike train measurement" ; obo:IAO_0000119 "Jessica Turner, NIF" ; a owl:Class ; rdfs:label "spike train datum" ; rdfs:subClassOf obo:IAO_0000109 . obo:OBI_0000802 obo:IAO_0000111 "prothrombin time assay" ; obo:IAO_0000112 "PMID:19696660#The prothrombin time (PT) was quantitatively determined using RecombiPlasTin (Instrumentation Laboratory Company, Lexington, Massachusetts, USA)." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures the prothrombin ratio, which is the prothrombin time for a patient, divided by the result for control plasma. Most commonly the test is preformed using blood plasma. Blood is drawn into a test tube containing liquid citrate, which acts as an anticoagulant. An excess of calcium is added to enable the blood to clot again.Tissue factor (also known as factor III or thromboplastin) is added, and the time the sample takes to clot is measured optically as the prothrombin time, which is compared to a control sample." ; obo:IAO_0000117 "Alan Ruttenberg" ; obo:IAO_0000119 "url:http://en.wikipedia.org/wiki/Prothrombin_time@2009/10/06" ; a owl:Class ; rdfs:label "prothrombin time assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000032 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0007596 ] ] . obo:OBI_0000803 obo:IAO_0000111 "denaturing" ; obo:IAO_0000112 "Denaturing DNA in alcohol" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Is a process in which the tertiary or secondary structure of a polymer is disrupted" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Denaturation_%28biochemistry%29" ; a owl:Class ; rdfs:label "denaturing" ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:CHEBI_33696 obo:PR_000000001 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0000804 obo:IAO_0000111 "informing investigator of subject study arm" ; obo:IAO_0000112 "Informing the investigator whether a patient is receiving a placebo or a treatment with an investigational compound." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process with the objective to make the investigator aware of which study arm a patient is participating in." ; obo:IAO_0000116 "09/28/2009 Alan Ruttenberg. This and the class informing-subject-of-study-arm are defined in order to solve the question of how to represent single and double blind experiments. To represent the aspect of double blinding pertaining to investigators, we say that the study execution doesn't include any processes of this sort" ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "informing investigator of subject study arm" ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000219 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:OBI_0000097 ] ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000202 ] ] ) ] . obo:OBI_0000805 obo:IAO_0000111 "antithrombin-III berichrome assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antithrombin-III (AT-III) assay in which exogenous bovine thrombin and heparin are added to test plasma to form a thrombin-heparin-AT complex. The residual thrombin not bound then hydrolyzes the p-nitroalanine substrate to produce a yellow color, which is read at 405 nm. The intensity of color produced is inversely proportional to the AT present. A calibration is done with standard human plasma reagent and results for a given specimen are reported as a percentage relative to the standard" ; obo:IAO_0000118 "AT-III assay" ; obo:IAO_0000119 "url:http://www.clinchem.org/cgi/content/full/43/9/1783@2009/08/06" ; a owl:Class ; rdfs:label "antithrombin-III berichrome assay" ; rdfs:subClassOf obo:OBI_0000787, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000032 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom obo:OBI_0000815 ] [ a owl:Restriction ; owl:cardinality "1"^^xsd:nonNegativeInteger ; owl:onProperty obo:OBI_0000299 ] ) ] . obo:OBI_0000806 obo:IAO_0000111 "material maintenance objective" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An objective specification maintains some or all of the qualities of a material over time." ; obo:IAO_0000117 "PERSON: Bjoern Peters" ; obo:IAO_0000119 "PERSON: Bjoern Peters" ; a owl:Class ; rdfs:label "material maintenance objective" ; rdfs:subClassOf obo:IAO_0000005 . obo:OBI_0000807 obo:IAO_0000111 "presentation of stimulus" ; obo:IAO_0000112 "The presentation of a flashing light to a monkey during reward training" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process with the objective to expose an organism to a stimulus." ; obo:IAO_0000117 "Helen Parkinson, Jessica Turner, Dirk Derom" ; obo:IAO_0000118 "stimulation of organism" ; obo:IAO_0000119 "Helen Parkinson, Jessica Turner, Dirk Derom" ; a owl:Class ; rdfs:label "presentation of stimulus" ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000097 ] ) ] ] . obo:OBI_0000808 obo:IAO_0000111 "spectrolyse heparin antifactor-Xa assay" ; obo:IAO_0000112 "PMID:19696660#Antifactor-Xa (anti-Xa) was determined using spectrolyse heparin (Xa) (Trinity Biotech plc, Bray, County Wicklow, Ireland)." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that quantitatively measures heparin in human plasma using Factor Xa and Antithrombin III in excess, where the rate of Factor Xa inhibition is directly proportional to the heparin concentration. The residual Factor Xa activity, measured with a Factor Xa-specific chromogenic substrate, is inversely proportional to the heparin concentration." ; obo:IAO_0000117 "Alan Ruttenberg" ; obo:IAO_0000119 "url:http://www.kordia.nl/en/product/hemostasis/specialty_kits__reagens/598/spectrolyse_heparin_anti_xa@2009/08/06" ; a owl:Class ; rdfs:label "spectrolyse heparin antifactor-Xa assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000032 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0007596 ] ] . obo:OBI_0000809 obo:IAO_0000111 "amplified DNA" ; obo:IAO_0000112 "Amplied DNA created by PCR" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "DNA that has been produced in an enzymatic amplification process" ; obo:IAO_0000117 "PERSON: Alan Ruttenberg" ; obo:IAO_0000119 "Alan Ruttenberg" ; a owl:Class ; rdfs:label "amplified DNA" ; rdfs:subClassOf obo:CHEBI_16991, obo:OBI_0000047 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16991 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600058 ] ) ] . obo:OBI_0000810 obo:IAO_0000111 "informed consent process" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A planned process with the objective to inform a person or their legal representative of legally and ethically relevant facts about a process that the person in question is asked to participate in, and which results in a documented decision as to whether the person in question will participate." ; obo:IAO_0000116 "09/28/2009 Alan Ruttenberg: This is made a subclass of the higher level processual entity in BFO because I don't want to take a stand on whether it is a process aggregate. Analogous to the situation with Material entity." ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000119 "http://clinicaltrials.gov/ct2/info/glossary#informed" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "informed consent process" ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:NCBITaxon_9606 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000202 ] ] . obo:OBI_0000811 obo:IAO_0000111 "primary structure of DNA macromolecule" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a quality of a DNA molecule that inheres in its bearer due to the order of its DNA nucleotide residues." ; obo:IAO_0000116 "placeholder for SO" ; obo:IAO_0000117 "BP et al" ; a owl:Class ; rdfs:label "primary structure of DNA macromolecule" ; rdfs:subClassOf obo:SO_0000001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:RO_0000058 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16991 ] ] . obo:OBI_0000812 obo:IAO_0000111 "measuring neural activity in the caudate nucleus assay" ; obo:IAO_0000112 "An SU micro-electrode was used to measure neural activity in the form of spike trains in the caudate nucleus of monkeys in response to a flashing light stimulus" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures neural activity in the caudate nucleus" ; obo:IAO_0000117 "Helen Parkinson" ; obo:IAO_0000119 "Dirk Derom, OBI", "Jessica Turner, NIF" ; a owl:Class ; rdfs:label "measuring neural activity in the caudate nucleus assay" ; rdfs:subClassOf obo:OBI_0000454 . obo:OBI_0000813 obo:IAO_0000111 "to be treated with active ingredient role" ; obo:IAO_0000112 "Role of a patient in a group treated with an active substance in a clinical trial" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A study subject role which begins to exist when a subject is assigned to be one of those who will receive active ingredient, and is realized in a study execution in which they receive the active ingredient" ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000119 "PERSON: Helen Parkinson" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "to be treated with active ingredient role" ; rdfs:subClassOf obo:OBI_0000097 . obo:OBI_0000814 obo:IAO_0000111 "guar gum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Guar gum, also called guaran, is a galactomannan. It is primarily the ground endosperm of guar beans. The guar seeds are dehusked, milled and screened to obtain the guar gum.[1] It is typically produced as a free flowing, pale, off-white colored, coarse to fine ground powder." ; obo:IAO_0000117 "Helen Parkinson" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Guar_gum" ; a owl:Class ; rdfs:label "guar gum" ; rdfs:subClassOf obo:BFO_0000040 . obo:OBI_0000815 obo:IAO_0000111 "Berichrom(r) Antithrombin III (A) Kit" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "For the chromogenic determination of antithrombin III. Autoanalyzer method for undiluted samples. For the quantitative chromogenic determination of the functional activity of antithrombin III in plasma on autoanalyzers for the diagnosis of diminished AT III synthesis, increased consumption, and for monitoring substitution therapy. Berichrom(r) Antithrombin III (A) is used for the rapid determination of the physiologically active antithrombin III and permits the diagnosis of congenital and acquired antithrombin III deficiency, a condition frequently associated with an increased risk of thrombosis. Acquired antithrombin III deficiencies frequently occur due to consumption following major operations or due to disseminated intravascular coagulation (DIC) in cases of septicaemia, nephroses, liver parenchymal damage (hepatitis, drug intoxication, alcoholism) and estrogen-containing contraceptives. The test permits early detection of patients at increased risk for thrombosis. Kit contains: 6 x for 5.0 mL Thrombin (bovine), 3 x for 3.0 mL Substrate Reagent, 1 x 30.0 mL Buffer Solution" ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000119 "WEB:http://www.dadebehring.com/edbna2/ebusiness/products/productDetail.jsp?sDiscipline=Hemostasis&FirstLevelOID=-13075&sCategory_Name=BCS&SecondLevelOID=-13895&ThirdLevelOID=-13904&selectedProductType=H-Assays+-+non+US&sProductName=OWWR15&PROD_OID=44198@2009/08/06" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "Berichrom(r) Antithrombin III (A) Kit" ; rdfs:subClassOf obo:OBI_0000047 . obo:OBI_0000816 obo:IAO_0000111 "micro electrode" ; obo:IAO_0000112 "A micro-electrode recording device used to record extracellular action potentialsin monkey caudate nucleus" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An electrode of very fine caliber consisting usually of a fine wire or a glass tube of capillary diameter drawn to a fine point and filled with saline or a metal used in physiological experiments to stimulate or record action currents of extracellular or intracellular origin in the nervous system." ; obo:IAO_0000117 "Helen Parkinson, Jessica Turner, Dirk Derom" ; obo:IAO_0000118 "micro electrode measuring device" ; obo:IAO_0000119 "Jessica Turner, Dirk Derom" ; a owl:Class ; rdfs:label "micro electrode" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000817 obo:IAO_0000111 "fucoidan" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Fucoidan is a sulfated polysaccharide (MW: average 20,000) found mainly in various species of brown seaweed such as kombu, limu moui,bladderwrack, wakame, mozuku, and hijiki (variant forms of fucoidan have also been found in animal species, including the sea cucumber)." ; obo:IAO_0000117 "Helen Parkinson" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Fucoidan" ; a owl:Class ; rdfs:label "fucoidan" ; rdfs:subClassOf obo:CHEBI_23367 . obo:OBI_0000818 obo:IAO_0000111 "calibration" ; obo:IAO_0000112 "the process of using pH buffer adjust a pH meter" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A planned process with the objective to establish the relationship between data produced by a measurement device and physical qualities. This is done by using the measurement device under defined conditions, and either tuning it to adjust the measured output, or record the output and use it as a reference in future measurements." ; obo:IAO_0000117 "GROUP: OBI Philly workshop" ; obo:IAO_0000119 "WEB:http://en.wikipedia.org/wiki/calibration" ; a owl:Class ; rdfs:label "calibration" ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000070 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000832 ] . obo:OBI_0000819 obo:IAO_0000111 "anticoagulant tube storage of blood specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Storage of a blood specimen in a tube with anticoagulant" ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "anticoagulant tube storage of blood specimen" ; rdfs:subClassOf obo:OBI_0302893, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100017 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000784 [ a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:OBI_0100017 ] ) ] ] ) ] . obo:OBI_0000820 obo:IAO_0000111 "activated partial thromboplastin time assay" ; obo:IAO_0000112 "The activated partial thromboplastin time (aPTT) was determined using Dade Actin FSL activated PTT reagent (PMID:19696660)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that evaluates blood coagulation by measuring the time required for the appearance of fibrin strands following the mixing blood or plasma with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of blood coaguation . It is used as a screening test and to monitor heparin therapy." ; obo:IAO_0000116 "There is also the 'partial thromboplastin assay', which some people use synonymously to aPPT, but historically was done slightly differently (without adding a coagulant)." ; obo:IAO_0000117 "Alan Ruttenberg", "OBI call" ; obo:IAO_0000118 "aPTT assay" ; obo:IAO_0000119 "url:http://www.ebi.ac.uk/ols/ontologies/efo/terms?short_form=EFO_0004310" ; a owl:Class ; rdfs:label "activated partial thromboplastin time assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0000655 obo:OBI_0100016 ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:unionOf (obo:OBI_0000655 obo:OBI_0100016 ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000416 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0007596 ] ] . obo:OBI_0000821 obo:IAO_0000111 "filled capsule" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pill in the form of a small rounded gelatinous container with medicine inside." ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000119 "http://www.golovchenko.org/cgi-bin/wnsearch?q=capsule#2n" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "filled capsule" ; rdfs:subClassOf obo:OBI_0000827, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000798 ] . obo:OBI_0000822 obo:IAO_0000111 "single blind study execution" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A single blind study execution is defined as any study execution in which the subjects are not informed of which study arm they are part of during the portion of the trial when the subjects are being treated" ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000119 "http://clinicaltrials.gov/ct2/info/glossary#single" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "single blind study execution" ; rdfs:subClassOf obo:OBI_0000826 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000826 [ a owl:Restriction ; owl:allValuesFrom [ a owl:Class ; owl:complementOf obo:OBI_0000842 ] ; owl:onProperty obo:BFO_0000051 ] ) ] . obo:OBI_0000823 obo:IAO_0000111 "thrombin time assay" ; obo:IAO_0000112 "PMID:19696660#The thrombin time was determined using thromboclotin assay kit." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures the time between the addition of the thrombin and the clot formation in plasma." ; obo:IAO_0000117 "Alan Ruttenberg" ; obo:IAO_0000119 "url:http://en.wikipedia.org/wiki/Thrombin_time@2009/10/06" ; a owl:Class ; rdfs:label "thrombin time assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000032 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0007596 ] ] . obo:OBI_0000824 obo:IAO_0000111 "recombinant YAC cloning" ; obo:IAO_0000112 "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Recombinant YAC cloning is a process with the objective to insert genetic material into a yeast artificial chromosome vector for future replication of the inserted material" ; obo:IAO_0000117 "Helen Parkinson" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mcb.section.1611" ; a owl:Class ; rdfs:label "recombinant YAC cloning" ; rdfs:subClassOf obo:OBI_0600064 . obo:OBI_0000825 obo:IAO_0000111 "to be treated with placebo role" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study subject role which begins to exist when a subject is assigned to be one of those who will receive a placebo, and realized in a study execution in which they receive the placebo" ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "to be treated with placebo role" ; rdfs:subClassOf obo:OBI_0000097 . obo:OBI_0000826 obo:IAO_0000111 "treatment portion of study execution" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process, part of a study design execution, during which the treatment of subjects is ongoing" ; obo:IAO_0000116 "09/28/2009 Alan Ruttenberg. Needed because we have to have a process to scope blinding over" ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "treatment portion of study execution" ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0000471 ] . obo:OBI_0000827 obo:IAO_0000111 "pill" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A dose of medicine or placebo in the form of a small pellet." ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000119 "http://www.golovchenko.org/cgi-bin/wnsearch?q=pill#2n" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "pill" ; rdfs:subClassOf obo:OBI_0000047 . obo:OBI_0000828 obo:IAO_0000111 "research organization" ; obo:IAO_0000112 "The SALK institute is a research organization." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An organization formed with a goal to have its members conduct investigations" ; obo:IAO_0000117 "Person:Bjoern Peters" ; a owl:Class ; rdfs:label "research organization" ; rdfs:subClassOf obo:OBI_0000245 . obo:OBI_0000829 obo:IAO_0000111 "Sysmex Corporation, Kobe, Japan" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000119 "WEB:http://www.sysmex.com/@2009/08/06" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Sysmex Corporation, Kobe, Japan" . obo:OBI_0000830 obo:IAO_0000111 "obsolete_primary structure of sequence macromolecule" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A quality inhering in a molecule that is completely defined by the linear sequence of a set of residues which are connected by directional, linear bonds" ; obo:IAO_0000117 "Person:Bjoern Peters" ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:Class ; rdfs:label "obsolete_primary structure of sequence macromolecule" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000831 obo:IAO_0000111 "DNA residue methylation" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a quality of a DNA residue that has a methyl group attached to it" ; a owl:Class ; rdfs:label "DNA residue methylation" ; rdfs:subClassOf obo:PATO_0001241 . obo:OBI_0000832 obo:IAO_0000111 "measurement device" ; obo:IAO_0000112 "A ruler, a microarray scanner, a Geiger counter." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A device in which a measure function inheres." ; obo:IAO_0000117 "GROUP:OBI Philly workshop" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "measurement device" ; rdfs:subClassOf obo:OBI_0000968 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000968 [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] ) ] . obo:OBI_0000833 obo:IAO_0000111 "objective_achieved_by" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "This relation obtains between an objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process." ; obo:IAO_0000117 "OBI" ; obo:IAO_0000119 "OBI" ; a owl:ObjectProperty ; rdfs:domain obo:IAO_0000005 ; rdfs:label "objective_achieved_by" ; rdfs:range obo:OBI_0000011 . obo:OBI_0000834 obo:IAO_0000111 "high molecular weight DNA extract" ; obo:IAO_0000112 "Extraction of chromosomal DNA from mammalian cells by first isolating nucei" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The output of an extraction process in which DNA molecules above a molecular weight cutoff are purified in order to exclude DNA from organellas." ; obo:IAO_0000117 "PERSON:Chris Stoeckert" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "high molecular weight DNA extract" ; rdfs:subClassOf obo:OBI_0001051 . obo:OBI_0000835 obo:IAO_0000111 "manufacturer" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A person or organization that has a manufacturer role." ; a owl:Class ; rdfs:label "manufacturer" ; rdfs:subClassOf obo:BFO_0000040 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:unionOf (obo:NCBITaxon_9606 obo:OBI_0000245 ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000571 ] ) ] . obo:OBI_0000836 obo:IAO_0000111 "test tube" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A test tube is a device consisting of a glass or plastic tubing, open at the top, usually with a rounded U-shaped bottom which has the function to contain material" ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000118 "collection tube", "sample tube" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Test_tube" ; a owl:Class ; rdfs:label "test tube" ; rdfs:subClassOf obo:OBI_0000522, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000370 ] . obo:OBI_0000837 obo:IAO_0000111 "oral ingestion of pill" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An adding a material entity to target with the entity is a pill and the target is the mouth" ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "oral ingestion of pill" ; rdfs:subClassOf obo:OBI_0000952 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000952 [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000319 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000827 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000827 ] ) ] . obo:OBI_0000838 obo:IAO_0000111 "material maintenance" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A planned process with the objective to maintain some or all of the characteristics of an input material over time." ; a owl:Class ; rdfs:label "material maintenance" ; rdfs:subClassOf obo:OBI_0000011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000806 ] . obo:OBI_0000839 obo:IAO_0000111 "labeled oligonucleotide" ; obo:IAO_0000112 "" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a labeled oligonucleotide is a short nucleic acid which underwent a labeling process resulting in a radioactive isotope such as P32 or P33 added to its backbone for instance by end labeling with polynucleotide kinase which added radiolabeled ATP to the 5' end of oligonucleotide" ; obo:IAO_0000116 """2010-01-31: Philippe Rocca-Serra placeholder""" ; obo:IAO_0000117 "Person: Philippe Rocca-Serra" ; a owl:Class ; rdfs:label "labeled oligonucleotide" ; rdfs:subClassOf obo:OBI_0001936, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0002744 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600038 ] . obo:OBI_0000840 obo:IAO_0000111 "unblinding process" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process that is the part of the study execution in which the subjects are told what study arm they are in and in which the investigators are told which subjects are in which trials." ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "unblinding process" ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0000471 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0000842 ] ) ] . obo:OBI_0000841 obo:IAO_0000111 "subject agrees they understand informed consent document" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process in which a subject receives an informed consent document and agrees that they have understood it." ; obo:IAO_0000116 "09/28/2009 Alan Ruttenberg. There's a need for a general process like this in IAO - document and person in, signed document (and associated obligations, rights, out" ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "subject agrees they understand informed consent document" ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0000810 ] . obo:OBI_0000842 obo:IAO_0000111 "informing subject of study arm" ; obo:IAO_0000112 "Informing participants whether they are receiving a placebo or a treatment with an investigational compound." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process with the objective to make the subject aware of which study arm they are participating in." ; obo:IAO_0000116 "09/28/2009 Alan Ruttenberg. This and the class informing-investigator-of-study-arm are defined in order to solve the question of how to represent single and double blind experiments. To represent the aspect of blinding pertaining to subjects (happens in single and double blinding) we say that that the study execution doesn't include any processes of this sort" ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "informing subject of study arm" ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0000810 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000097 ] ] ) ] . obo:OBI_0000843 obo:IAO_0000111 "Sysmex CA-6000 Coagulation Analyzer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The Sysmex CA-6000 automated coagulation analyzer is a random access instrument that is capable of performing 20 clot-based and chromogenic assays" ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000119 "web:http://www.clinchem.org/cgi/content/full/43/9/1783@2009/08/06" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:Class ; rdfs:label "Sysmex CA-6000 Coagulation Analyzer" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ], [ a owl:Restriction ; owl:hasValue obo:OBI_0000829 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0000844 obo:IAO_0000111 "obsolete hospital" ; obo:IAO_0000112 "human ethics approval was obtained from the Southern Tasmania Health & Medical Human Research Ethics Committee and the Royal Hobart Hospital Research Ethics Committee [pmid:19696660]" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A medical organization at which sick or injured people are given clinical care" ; obo:IAO_0000117 "Person:Alan Ruttenberg", "Person:Helen Parkinson" ; obo:IAO_0000119 "modified from the wording of the wordnet definition; http://www.golovchenko.org/cgi-bin/wnsearch?q=hospital#2n" ; obo:IAO_0000231 obo:IAO_0000228 ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1295" ; obo:IAO_0100001 obo:OMRSE_00000056 ; a owl:Class ; rdfs:label "obsolete hospital" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000845 obo:IAO_0000111 "primary structure of RNA molecule" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The primary structure of an RNA molecule that is completely defined by the set of its nucleic residue parts and the linear order induced by the peptide bonds that hold them together" ; obo:IAO_0000117 "Person:Bjoern Peters" ; a owl:Class ; rdfs:label "primary structure of RNA molecule" ; rdfs:subClassOf obo:SO_0000001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:RO_0000058 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33697 ] ] . obo:OBI_0000846 obo:IAO_0000111 "is member of organization" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Relating a legal person or organization to an organization in the case where the legal person or organization has a role as member of the organization." ; obo:IAO_0000116 "2009/10/01 Alan Ruttenberg. Barry prefers generic is-member-of. Question of what the range should be. For now organization. Is organization a population? Would the same relation be used to record members of a population", "JZ: Discussed on May 7, 2012 OBI dev call. Bjoern points out that we need to allow for organizations to be members of organizations. And agreed by the other OBI developers. So, human and organization were specified in 'Domains'. The textual definition was updated based on it." ; obo:IAO_0000117 "Person:Alan Ruttenberg", "Person:Helen Parkinson" ; obo:IAO_0000119 "Person:Alan Ruttenberg", "Person:Helen Parkinson" ; obo:IAO_0000232 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" ; a owl:ObjectProperty ; rdfs:domain [ a owl:Class ; owl:unionOf (obo:NCBITaxon_9606 obo:OBI_0000245 ) ] ; rdfs:label "is member of organization" ; rdfs:range obo:OBI_0000245 ; owl:inverseOf obo:OBI_0001688 . obo:OBI_0000847 obo:IAO_0000111 "test substance role" ; obo:IAO_0000112 "fucoidan bears a test substance role in a study to test safety taking a certain dosage of it orally" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A role born by a material entity and realized in a process where the substance is used as specified as the independent variable for an investigation" ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000119 "Group:OBI" ; a owl:Class ; rdfs:label "test substance role" ; rdfs:subClassOf obo:BFO_0000023 . obo:OBI_0000848 obo:IAO_0000111 "polyA RNA extraction" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A RNA extraction process typically involving the use of poly dT oligomers in which the desired output material is polyA RNA." ; obo:IAO_0000117 "Person: Chris Stoeckert", "Person: Jie Zheng" ; obo:IAO_0000119 "UPenn Group" ; a owl:Class ; rdfs:label "polyA RNA extraction" ; rdfs:subClassOf obo:OBI_0666666 . obo:OBI_0000849 obo:IAO_0000111 "organellar RNA extraction" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A RNA extraction process in which the desired output material is RNA in the organelle(s)." ; obo:IAO_0000117 "Person: Chris Stoeckert", "Person: Jie Zheng" ; obo:IAO_0000119 "UPenn Group" ; a owl:Class ; rdfs:label "organellar RNA extraction" ; rdfs:subClassOf obo:OBI_0666666 . obo:OBI_0000850 obo:IAO_0000111 "obsolete_the manufacturer role of Agilent" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:NamedIndividual, owl:Thing ; rdfs:label "obsolete_the manufacturer role of Agilent" ; owl:deprecated true . obo:OBI_0000851 obo:IAO_0000111 "obsolete_diethyl pyrocarbonate" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:Class ; rdfs:label "obsolete_diethyl pyrocarbonate" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000852 obo:IAO_0000111 "record of missing knowledge" ; obo:IAO_0000112 "A statement in a journal article indicating that the age of a patient at the onset of disease is not known. A statement indicating that the weight of a mouse was not measured." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An information content entity created to indicate that information about something is not available to the person recording it." ; obo:IAO_0000116 "This class should probably end up in IAO. It could be further breaken down to indicate different kinds of lack of knowledge, e.g. inability to determine something vs. no attempt made to determine something vs. no informatino available if it was even attempted to determine something. The design pattern should be generalizable. 'unknown sex' is the first example, and needed immediately." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "" ; a owl:Class ; rdfs:label "record of missing knowledge" ; rdfs:subClassOf obo:IAO_0000030 . obo:OBI_0000853 obo:IAO_0000111 "obsolete_manufacturer role of Bruker Daltonics" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:NamedIndividual, owl:Thing ; rdfs:label "obsolete_manufacturer role of Bruker Daltonics" ; owl:deprecated true . obo:OBI_0000854 obo:IAO_0000111 "western blot assay" ; obo:IAO_0000112 "Running a cell lysate on an acrylamide gel in a western blot aparatus to separate the constituent proteins, followed by transfer of the proteins from the gel to a nitrocellulose membrane. Staining this membrane with specific antibodies to detect the presence of specific proteins of interest." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that detects specific peptides in an input material by separating it using gel electrophoresis, transfering the separated molecules to a membrane, and staining them with_ antibodies specific to the analyte molecules." ; obo:IAO_0000117 "IEDB", "Philippe Rocca-Serra" ; obo:IAO_0000119 "IEDB", "Philippe Rocca-Serra" ; a owl:Class ; rdfs:label "western blot assay" ; rdfs:subClassOf obo:OBI_0001978, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16670 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16670 ] ) ] . obo:OBI_0000855 obo:IAO_0000111 "total RNA extraction" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A RNA extraction process in which total cellular and organelle RNA are extracted." ; obo:IAO_0000117 "Person: Chris Stoeckert", "Person: Jie Zheng" ; obo:IAO_0000119 "UPenn Group" ; a owl:Class ; rdfs:comment "" ; rdfs:label "total RNA extraction" ; rdfs:subClassOf obo:OBI_0666666 . obo:OBI_0000856 obo:IAO_0000111 "obsolete intracellular material detection by flow cytometry assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay in which the presence of a material inside a cell is measured by permeabilizing the cell membrane to allow entry of specific antibodies, and counting the stained cells using a flow cytometer." ; obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:OBI_0000916 ; obo:OBI_9991118 "intracellular staining" ; a owl:Class ; rdfs:label "obsolete intracellular material detection by flow cytometry assay" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000857 obo:IAO_0000111 "complementary nucleotide probe role" ; obo:IAO_0000112 "A primer in a PCR reaction. A probe on an Affymetrix chip." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A role played by a nucleic acid molecule that is used in a planned process for its ability to bind a nucleic acid molecules with complementary nucleotide sequence" ; obo:IAO_0000117 "PERSON:Bjoern Peters" ; a owl:Class ; rdfs:label "complementary nucleotide probe role" ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33696 ] . obo:OBI_0000858 obo:IAO_0000111 "record of unknown sex" ; obo:IAO_0000112 "A database record indicating that the tissue sample in a microarray experiment came from an organism for which the biological sex is not known to the person who created the record." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a record indicating that the biological sex of an organism is not known." ; obo:IAO_0000116 "I think the statement is still about the instance of the biological sex quality of an organism. It is also about information available to the person making the statement." ; obo:IAO_0000117 "Bjoern Peters" ; a owl:Class ; rdfs:label "record of unknown sex" ; rdfs:subClassOf obo:OBI_0000852, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PATO_0000047 ] . obo:OBI_0000859 obo:IAO_0000111 "cytoplasmic RNA extraction" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A RNA extraction process in which the desired output material is RNA in the cytoplasm." ; obo:IAO_0000117 "Person: Chris Stoeckert", "Person: Jie Zheng" ; obo:IAO_0000119 "UPenn Group" ; a owl:Class ; rdfs:label "cytoplasmic RNA extraction" ; rdfs:subClassOf obo:OBI_0666666 . obo:OBI_0000860 obo:IAO_0000111 "northern blot assay" ; obo:IAO_0000112 "The level of actin mRNA levels in normal and diseased tiisue was measured using a northern blot assay." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay that determines the presence of gene transcripts by hybridizing labeled RNA or DNA probes against messenger RNAs isolated from tissue or cell cultures, resolved on denaturing gel, transfered by a blotting procedure to a solid support. Detection of hybridization signals is carried out by immunofluorescence or radioactivity measurements using photographic films or digital imaging devices such as Phosphor Imager." ; obo:IAO_0000117 "Philippe Rocca-Serra", "Richard Scheuermann" ; obo:IAO_0000118 "northern blot" ; a owl:Class ; rdfs:label "northern blot assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33697 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33697 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ] . obo:OBI_0000861 obo:IAO_0000111 "Likelihood-ratio test" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Likelihood-ratio is a data transformation which tests whether there is evidence of the need to move from a simple model to a more complicated one (where the simple model is nested within the complicated one); tests of the goodness-of-fit between two models." ; obo:IAO_0000117 "Tina Boussard" ; a owl:Class ; rdfs:label "Likelihood-ratio test" ; rdfs:subClassOf obo:OBI_0200000 . obo:OBI_0000862 obo:IAO_0000111 "nuclear RNA extract" ; obo:IAO_0000112 "Isolation and purification of nuclear RNA from animal cells using Norgen Bioteck corp. cytoplasmic and nuclear RNA purification kit (http://www.norgenbiotek.com/display-product.php?ID=30)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A RNA extract that is the output of an extraction process in which RNA molecules found in the nucleus, including mRNA precursors (pre-mRNA), are extracted." ; obo:IAO_0000117 "PERSON: Chris Stoeckert", "PERSON: Jie Zheng" ; obo:IAO_0000119 "UPenn Group" ; a owl:Class ; rdfs:label "nuclear RNA extract" ; rdfs:subClassOf obo:OBI_0000880, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000888 ] . obo:OBI_0000863 obo:IAO_0000111 "obsolete_the manufacturer role of Thermo" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:NamedIndividual, owl:Thing ; rdfs:label "obsolete_the manufacturer role of Thermo" ; owl:deprecated true . obo:OBI_0000864 obo:IAO_0000111 "obsolete_the manufacturer role of Li-Cor" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:NamedIndividual, owl:Thing ; rdfs:label "obsolete_the manufacturer role of Li-Cor" ; owl:deprecated true . obo:OBI_0000865 obo:IAO_0000111 "96-well neutralization assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A serum neutralization of viral infectivity assay which is performed in a 96-well plate." ; obo:IAO_0000117 "Bjoern Peters", "Melanie Courtot" ; obo:IAO_0000118 "microneutralization assay" ; a owl:Class ; rdfs:label "96-well neutralization assay" ; rdfs:subClassOf obo:OBI_0000872, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400076 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400076 ] ) ] . obo:OBI_0000866 obo:IAO_0000111 "obsolete_the manufacturer role of Roche" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:NamedIndividual, owl:Thing ; rdfs:label "obsolete_the manufacturer role of Roche" ; owl:deprecated true . obo:OBI_0000867 obo:IAO_0000111 "establishing cancer cell line" ; obo:IAO_0000112 "Establishment of HeLa immortal cell line" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is a planned process in which the objective is to generate a cell line from a natural population of cancer cells which are already immortal" ; obo:IAO_0000119 "" ; a owl:Class ; rdfs:comment "Helen Parkinson" ; rdfs:label "establishing cancer cell line" ; rdfs:subClassOf obo:OBI_0001867, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001906 ] . obo:OBI_0000868 obo:IAO_0000111 "pattern matching objective" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A pattern matching objective aims to detect the presence of the constituents of a given pattern. In contrast to pattern recognition, the pattern is rigidly specified. Patterns are typicall sequences or trees." ; obo:IAO_0000117 "Tina Boussard" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Pattern_matching" ; a owl:Class ; rdfs:label "pattern matching objective" ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0000869 obo:IAO_0000111 "polyA RNA extract" ; obo:IAO_0000112 "Preparation of polyA RNA by cellulose-bound oligo-dT (Aviv, H., Leder, P. 1972. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc. Nat. Acad. Sci. USA 69, 1408-1412.)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A RNA extract that is the output of an extraction process in which RNA molecules with poly A tail at its 3' end are purified." ; obo:IAO_0000117 "PERSON: Chris Stoeckert", "PERSON: Jie Zheng" ; obo:IAO_0000119 "UPenn Group" ; a owl:Class ; rdfs:label "polyA RNA extract" ; rdfs:subClassOf obo:OBI_0000880, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000848 ] . obo:OBI_0000870 obo:IAO_0000111 "single-nucleotide-resolution nucleic acid structure mapping assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that provides information about the secondary structure of nucleic acids using chemical or enzymatic probing to establish the extent of base-pairing or solvent accessiblity." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "RNAO" ; a owl:Class ; rdfs:label "single-nucleotide-resolution nucleic acid structure mapping assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000885 ] ] ) ] . obo:OBI_0000871 obo:IAO_0000111 "viral hemagglutination assay" ; obo:IAO_0000112 "Determining the viral titer of a virus infected human by measuring the presence of hemagglutination when dilutions of serum samples are added to a known quantity of red blood cells." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that quantifies viruses by their hemagglutination activity." ; obo:IAO_0000117 "Bjoern Peters", "Melanie Courtot", "Randi Vita" ; obo:IAO_0000118 "HA", "HI", "viral haemagglutinin assay" ; obo:IAO_0000119 "url:http://en.wikipedia.org/wiki/Hemagglutination_assay" ; a owl:Class ; rdfs:label "viral hemagglutination assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000906 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ] . obo:OBI_0000872 obo:IAO_0000111 "serum neutralization of viral infectivity assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures virus-neutralizing abilities of different sera. Different dilutions of serum are mixed with virus and used to infect cells. At the lower dilutions, antibodies will block infection, but at higher dilutions, there will be too few antibodies to have an effect.The neutralization titer is expressed as the reciprocal of the highest dilution at which virus infection is blocked." ; obo:IAO_0000117 "Bjoern Peters", "Melanie Courtot" ; obo:IAO_0000118 "influenza neutralization assay" ; obo:IAO_0000119 "url:http://www.virology.ws/2009/05/28/influenza-microneutralization-assay/" ; a owl:Class ; rdfs:label "serum neutralization of viral infectivity assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0100017 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100017 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NCBITaxon_10239 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:NCBITaxon_10239 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0097282 ] ] . obo:OBI_0000873 obo:IAO_0000111 "pre-mortem specimen" ; obo:IAO_0000112 "material obtained through a liver biopsy from a human patient" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a specimen that was taken from a live organism" ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "MO_705 premortem"@en ; a owl:Class ; rdfs:label "pre-mortem specimen" ; rdfs:subClassOf obo:OBI_0001506 ; owl:disjointWith obo:OBI_0000902 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ) ] ] . obo:OBI_0000874 obo:IAO_0000111 "detection of specific nucleic acid polymers with complementary probes" ; obo:IAO_0000112 "Primer based PCR assay, Norther blot, Southern Blot, and RNAse protection assays." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay in which a specified input material (the evaluant) is examined for the presence or quantity of specified nucleic acid polymers, which are identified based on the use of complementary nucleic acid probes." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "detection of specific nucleic acid polymers with complementary probes" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33696 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000857 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33696 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000857 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33696 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33696 ] ) ] ) ] . obo:OBI_0000875 obo:IAO_0000111 "viral hemagglutination inhibition assay" ; obo:IAO_0000112 "Examining the ability of a monoclonal antibody to inhibit hemagglutination by Influenza A virus by comparing the levels of hemagglutination with and without the presence of the antibody." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures the ability of an evaluant to inhibit hemagglutination by a virus. Hemagglutinin is a viral protein which binds to sialic acid receptors on cells or to erythrocytes, causing the cells to clump. Loss of clumping indicates that the evaluant blocks binding of hemagglutinin to sialic acid receptors." ; obo:IAO_0000117 "Bjoern Peters", "Melanie Courtot", "Randi Vita" ; obo:IAO_0000118 "HAI", "HIA", "biological activity", "hemagglutination inhibition", "viral haemagglutinin inhibition assay" ; obo:IAO_0000119 "OBI branch derived" ; a owl:Class ; rdfs:label "viral hemagglutination inhibition assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NCBITaxon_10239 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:NCBITaxon_10239 ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000906 ] . obo:OBI_0000876 obo:IAO_0000111 "cytoplasmic RNA extract" ; obo:IAO_0000112 "Cytoplasmic RNA extraction from mammalian tissues to create cDNA library (Carninci P, Nakamura M, Sato K, Hayashizaki Y, Brownstein MJ. Cytoplasmic RNA extraction from fresh and frozen mammalian tissues. Biotechniques. 2002;33:306–309.)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A RNA extract that is the output of a RNA extraction process in which RNA molecules found in the cytoplasm are extracted." ; obo:IAO_0000117 "PERSON: Chris Stoeckert", "PERSON: Jie Zheng" ; obo:IAO_0000119 "UPenn Group" ; a owl:Class ; rdfs:label "cytoplasmic RNA extract" ; rdfs:subClassOf obo:OBI_0000880, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000859 ] . obo:OBI_0000877 obo:IAO_0000111 "cell line immortalization" ; obo:IAO_0000112 "Production of a cell line for the purposes of experimentation e.g. EBV transformation of PBMs" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "an establishing cell line process whereby a mortal cell line is intentionally genetically modified to be capable of indefinite propagation and re-established as a new immortal cell line" ; obo:IAO_0000116 "4-20-13 MHB: This class was repositioned as a child of 'establishing cell line', based on the existing definition (\"the planned process of experimentally creating a cell line which is capable of dividing indefinitely in vitro\"), and examples and other annotations indicating the intent to describe a process through which a new immortal cell line is established from an existing mortal cell line using genetic modification techniques. The definition above was modified to clarify this perspective." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000118 "'establishing immortal cell line through directed genetic modification'" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:comment "A immortalizing genetic transformation of an existing population of cell line cells is required as part of this process, as are additional steps for selecting and propagating the cells output form this process into a cell line." ; rdfs:label "cell line immortalization" ; rdfs:subClassOf obo:OBI_0001867, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001907 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:CLO_0009828 ] . obo:OBI_0000878 obo:IAO_0000111 "obsolete_the manufacturer role of Ambion" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:NamedIndividual, owl:Thing ; rdfs:label "obsolete_the manufacturer role of Ambion" ; owl:deprecated true . obo:OBI_0000879 obo:IAO_0000111 "random primed DNA labeling" ; obo:IAO_0000112 """PMID: 8713846. Random primed 32P-labeling of DNA. Smith DR. Methods Mol Biol. 1996;58:27-9.""" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a labeling in which random primers are used to uniformly label input DNA" ; obo:IAO_0000116 "need to add Klenow subunit of DNA polymerase I under material entity" ; obo:IAO_0000117 """Person: Bjoern Peters Person: Chris Stoeckert""", "Person: Philippe Rocca-Serra" ; obo:IAO_0000119 "PMID: 6312838. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Feinberg AP, Vogelstein B. Anal Biochem. 1983 Jul 1;132(1):6-13." ; a owl:Class ; rdfs:label "random primed DNA labeling" ; rdfs:subClassOf obo:OBI_0600038 . obo:OBI_0000880 obo:IAO_0000111 "RNA extract" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "an extract which is the output of an extraction process in which RNA molecules are isolated from a specimen." ; obo:IAO_0000117 "PERSON: Chris Stoeckert", "PERSON: Jie Zheng" ; obo:IAO_0000119 "Group: UPenn Group" ; a owl:Class ; rdfs:label "RNA extract" ; rdfs:subClassOf obo:OBI_0001010, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0666666 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:CHEBI_33697 ] . obo:OBI_0000881 obo:IAO_0000111 "obsolete_the manufacturer role of BIO-RAD" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:NamedIndividual, owl:Thing ; rdfs:label "obsolete_the manufacturer role of BIO-RAD" ; owl:deprecated true . obo:OBI_0000882 obo:IAO_0000111 "cell-cell killing assay" ; obo:IAO_0000112 "Autologous EBV-transformed B-LCL were used as target cells for the influenza virus-specific CTL assays. Equal volumes of target and effector cells were added to tissue culture plates, and 1:2 serial dilutions of effectors were made. After a 4-h incubation of the effector cells with the target cells, supernatants were collected and counted with the LKB 1272 Clinigamma counter. Percent specific killing was determined with the following equation: (experimental 51Cr release - spontaneous 51Cr release)/(maximum 51Cr release - spontaneous 51Cr release) x 100." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that monitors a cell population to track how many are killed by other cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "cell-cell killing assay" ; rdfs:subClassOf obo:OBI_0001977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001977 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CL_0000000 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0001906 ] ] ) ] . obo:OBI_0000883 obo:IAO_0000111 "in vivo cell killing assay" ; obo:IAO_0000112 "Labeling two populations of cells with different levels of CFSE, pusling one population with an influenza peptide, injecting the cells into a mouse, and recoving cells 24 hours later. By comparing the recovery rate of cells with different CFSE labeling, it is possible to determine if there was specific killing of peptide pulsed target cells." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cell killing assay that measures if and how many target cells are killed within an organism." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "in vivo cell killing assay" ; rdfs:subClassOf obo:OBI_0000882 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000882 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0100026 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] ) ] . obo:OBI_0000884 obo:IAO_0000111 "obsolete_the regulator role of the FDA" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:NamedIndividual, owl:Thing ; rdfs:label "obsolete_the regulator role of the FDA" ; owl:deprecated true . obo:OBI_0000885 obo:IAO_0000111 "secondary structure of sequence macromolecule" ; obo:IAO_0000114 obo:IAO_0000002 ; obo:IAO_0000115 """A quality inhering in a molecule that refers to general three-dimensional form of local segments of biopolymers such as proteins and nucleic acids (DNA/RNA). It does not, however, describe specific atomic positions in three-dimensional space, which are considered to be tertiary structure. Secondary structure was introduced by Kaj Ulrik Linderstrøm-Lang in the 1952 Lane medical lectures at Stanford.""" ; obo:IAO_0000116 "2010-01-31: Philippe Rocca-Serra: This is a placeholder to allow work on 'nucleic acid mapping assay' in collaboration with RNAOntology group. Need to liaise with SO" ; obo:IAO_0000117 "Person: Philippe Rocca-Serra" ; obo:IAO_0000119 "Wikipedia" ; a owl:Class ; rdfs:label "secondary structure of sequence macromolecule" ; rdfs:subClassOf obo:PATO_0001241 . obo:OBI_0000886 obo:IAO_0000111 "obsolete_the manufacturer role of Illumina" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:NamedIndividual, owl:Thing ; rdfs:label "obsolete_the manufacturer role of Illumina" ; owl:deprecated true . obo:OBI_0000887 obo:IAO_0000111 "obsolete_the manufacturer role of Helicos" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:NamedIndividual, owl:Thing ; rdfs:label "obsolete_the manufacturer role of Helicos" ; owl:deprecated true . obo:OBI_0000888 obo:IAO_0000111 "nuclear RNA extraction" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A RNA extraction process in which the desired output material is RNA in the nucleus." ; obo:IAO_0000117 "Person: Chris Stoeckert", "Person: Jie Zheng" ; obo:IAO_0000119 "UPenn Group" ; a owl:Class ; rdfs:label "nuclear RNA extraction" ; rdfs:subClassOf obo:OBI_0666666 . obo:OBI_0000889 obo:IAO_0000111 "survival curve"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A survival curve is a report graph which is a graphical representation of data where the percentage of survival is plotted as a function of time."@en ; obo:IAO_0000117 "PERSON:Chris Stoeckert"@en, "PERSON:James Malone"@en, "PERSON:Melanie Courtot"@en ; obo:IAO_0000119 "WEB: http://www.graphpad.com/www/book/survive.htm"@en ; a owl:Class ; rdfs:label "survival curve"@en ; rdfs:subClassOf obo:IAO_0000573, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000789 ] . obo:OBI_0000890 obo:IAO_0000111 "obsolete_manufacturer role of Bruker Corporation" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:NamedIndividual, owl:Thing ; rdfs:label "obsolete_manufacturer role of Bruker Corporation" ; owl:deprecated true . obo:OBI_0000891 obo:IAO_0000111 "cell proliferation assay" ; obo:IAO_0000112 "Measuring the amount of tritiated thymidine incorporated by dividing cells as a proxy for cell proliferation." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay which measures the degreee to which input cells are replicating." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "cell proliferation assay" ; rdfs:subClassOf obo:OBI_0001977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001977 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0008283 ] ] ) ] . obo:OBI_0000892 obo:IAO_0000111 "Southern blot assay" ; obo:IAO_0000112 "PMID: 9452032. Germline mutations detected in the von Hippel-Lindau disease tumor suppressor gene by Southern blot and direct genomic DNA sequencing." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that detects the presence of a specific sequence in a DNA sample, which has been digested by restriction enzymes, resolved by gel electrophoresis, and blotted to a solid support, followed by hybridization of a probe raised against a specific sequence and detected with fluorescence or radioactivity." ; obo:IAO_0000117 "Marcus Chibucos", "Philippe Rocca-Serra" ; obo:IAO_0000118 "Southern blot" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "Southern blot assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16991 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16991 ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0302903 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 obo:OBI_0003368 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:BFO_0000029 ] ] . obo:OBI_0000893 obo:IAO_0000111 "real time polymerase chain reaction assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay, based on the PCR, that amplifies and simultaneously quantifies a specific DNA molecule based on the use of complementary probes/primers. It enables both detection and quantification (as absolute number of copies or relative amount when normalized to DNA input or additional normalizing genes) of one or more specific sequences in a DNA sample." ; obo:IAO_0000117 "Bjoern Peters", "Melanie Courtot" ; obo:IAO_0000118 "Q-PCR", "kinetic polymerase chain reaction", "qPCR", "quantitative real time polymerase chain reaction" ; obo:IAO_0000119 "url:http://en.wikipedia.org/wiki/Real-time_polymerase_chain_reaction" ; a owl:Class ; rdfs:label "real time polymerase chain reaction assay" ; rdfs:subClassOf obo:OBI_0002692, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000415 ] . obo:OBI_0000894 obo:IAO_0000111 "protein extract" ; obo:IAO_0000112 """PMID: 20032479. A bovine whey protein extract stimulates human neutrophils to generate bioactive IL-1Ra through a NF-kappaB- and MAPK-dependent mechanism. Rusu D, Drouin R, Pouliot Y, Gauthier S, Poubelle PE. J Nutr. 2010 Feb;140(2):382-91. Epub 2009 Dec 23.""" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a protein extract is the output of an extraction process from tissues or cell cultures resulting in a solution of cellular and/or organellar proteins in buffer solution used to prevent degradation," ; obo:IAO_0000117 "Person: Philippe Rocca-Serra" ; obo:IAO_0000119 "OBI & wikipedia" ; a owl:Class ; rdfs:label "protein extract" ; rdfs:subClassOf obo:OBI_0000423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000000001 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0302884 ] . obo:OBI_0000895 obo:IAO_0000111 "total RNA extract" ; obo:IAO_0000112 "Extraction of total RNA from cells with Qiagen mini RNeasy kit." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A RNA extract that is the output of an extraction process in which total celluar and organelle RNA molecules are isolated from a specimen." ; obo:IAO_0000117 "PERSON: Chris Stoeckert", "PERSON: Jie Zheng" ; obo:IAO_0000119 "UPenn Group" ; a owl:Class ; rdfs:label "total RNA extract" ; rdfs:subClassOf obo:OBI_0000880, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000855 ] . obo:OBI_0000896 obo:IAO_0000111 "secondary structure of RNA molecule" ; obo:IAO_0000112 "PMID: 15630685: Single molecule studies of RNA secondary structure: AFM of TYMV viral RNA." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "" ; obo:IAO_0000116 "2010-01-31: Philippe Rocca-Serra: This is a placeholder to allow work on 'nucleic acid mapping assay' in collaboration with RNAOntology group. Need to liaise with SO" ; obo:IAO_0000117 "Person: Philippe Rocca-Serra" ; a owl:Class ; rdfs:label "secondary structure of RNA molecule" ; rdfs:subClassOf obo:OBI_0000885 . obo:OBI_0000897 obo:IAO_0000111 "DEPC structure mapping assay" ; obo:IAO_0000112 "PMID:2446263. Probing the structure of RNAs in solution. Nucleic Acids Res. 1987 Nov 25;15(22):9109-28." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution nucleic acid structure mapping assay which determines nucleic acid secondary structure at a nucleotide resolution scale using DEPC as reagent and chemical probe" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "DEPC structure mapping assay" ; rdfs:subClassOf obo:OBI_0001017, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:CHEBI_16991 obo:CHEBI_33697 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000885 ] ] . obo:OBI_0000898 obo:IAO_0000111 "obsolete_the manufacturer role of Waters" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:NamedIndividual, owl:Thing ; rdfs:label "obsolete_the manufacturer role of Waters" ; owl:deprecated true . obo:OBI_0000899 obo:IAO_0000111 "organellar RNA extract" ; obo:IAO_0000112 "Extraction of organellar RNA from plant cells using organellar RNA binding protein." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A RNA extract that is the output of an extraction process in which RNA molecules found in an organelle, e.g., mitochondrion, ER, or chloroplast, excluding the nucleus, are extracted." ; obo:IAO_0000117 "PERSON: Chris Stoeckert", "PERSON: Jie Zheng" ; obo:IAO_0000119 "UPenn Group" ; a owl:Class ; rdfs:label "organellar RNA extract" ; rdfs:subClassOf obo:OBI_0000880, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000849 ] . obo:OBI_0000900 obo:IAO_0000111 "obsolete_manufacturer role of applied biosystems" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:NamedIndividual, owl:Thing ; rdfs:label "obsolete_manufacturer role of applied biosystems" ; owl:deprecated true . obo:OBI_0000901 obo:IAO_0000111 "U.S. Food and Drug Administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000118 "FDA" ; a obo:OBI_0000450, owl:NamedIndividual ; rdfs:label "U.S. Food and Drug Administration" . obo:OBI_0000902 obo:IAO_0000111 "post mortem specimen" ; obo:IAO_0000112 "the spleen taken from a dead mouse" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a specimen that was taken from a dead organism" ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "MO_416 postmortem"@en ; a owl:Class ; rdfs:label "post mortem specimen" ; rdfs:subClassOf obo:OBI_0001506 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001422 ] ) ] ] ) ] ] . obo:OBI_0000903 obo:IAO_0000111 "in vitro cell killing assay" ; obo:IAO_0000112 "Autologous EBV-transformed B-LCL were used as target cells for the influenza virus-specific CTL assays. Equal volumes of target and effector cells were added to tissue culture plates, and 1:2 serial dilutions of effectors were made. After a 4-h incubation of the effector cells with the target cells, supernatants were collected and counted with the LKB 1272 Clinigamma counter. Percent specific killing was determined with the following equation: (experimental 51Cr release - spontaneous 51Cr release)/(maximum 51Cr release - spontaneous 51Cr release) x 100." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cell killing assay that measures if and how many target cells are actively killed by other cells in a cell culture." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "in vitro cell killing assay" ; rdfs:subClassOf obo:OBI_0000882, obo:OBI_0003587 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000882 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0100060 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100060 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] ) ] . obo:OBI_0000904 obo:IAO_0000111 "reporter cell line analyte detection bioassay" ; obo:IAO_0000112 "CTLL-2 cells were grown in the presence of hybridoma supernatants and their growth was monitored by a 3H-thymidine incorporation cell proliferation assay in order to detect IL-2 in the hybridoma supernatant." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay in which a cell line whose growth is known to be affected by the presence of a specific type of material (the anlyte) is cultured in the presence of an input material (the evaluant) in order to detect presence of the analyte in the evaluant." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "reporter cell line analyte detection bioassay" ; rdfs:subClassOf obo:OBI_0000443, obo:OBI_0003587, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CLO_0000031 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CLO_0000031 ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0600024 ] . obo:OBI_0000905 obo:IAO_0000111 "sequence feature annotation" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Information about a sequence region" ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "Bjoern Peters" ; a owl:Class ; rdfs:comment "place holder for sequence ontology term" ; rdfs:label "sequence feature annotation" ; rdfs:subClassOf obo:IAO_0000030 . obo:OBI_0000906 obo:IAO_0000111 "induced hemagglutination" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The clumping or clustering of red blood cells caused by certain viruses, antibodies, or other substances" ; obo:IAO_0000116 """MC, 20100217: This term was originally submitted to GO, see discussion at http://sourceforge.net/tracker/index.php?func=detail&aid=2947975&group_id=36855&atid=440764. After discussion it was agreed that this isn't a natural in vivo process and therefore out of scope for GO. Dev call Nov 22, 2010: To reflect this, the term's label has been updated to 'induced hemagglutination'.""" ; obo:IAO_0000117 "person: Bjoern Peters", "person: Melanie Courtot" ; obo:IAO_0000118 "hemeagglutination" ; obo:IAO_0000119 "WEB: http://medical-dictionary.thefreedictionary.com/hemagglutination" ; a owl:Class ; rdfs:label "induced hemagglutination" ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CL_0000232 ] . obo:OBI_0000907 obo:IAO_0000111 "supplying" ; obo:IAO_0000112 "Jackson Labs supplies mouse strains." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process with the objective to provide material entities to be used in an investigation." ; obo:IAO_0000117 "Jennifer Fostel" ; obo:IAO_0000119 "Jennifer Fostel" ; obo:IAO_0000232 "5/31/2012: A supplying process implies that there is an acquisition process. These may need to be tied together, so that modeling either way is reciprocal." ; a owl:Class ; rdfs:label "supplying" ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:BFO_0000040 ] . obo:OBI_0000908 obo:IAO_0000111 "labeled DNA extract" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a labeled specimen that is the output of a labeling process and has grain labeled DNA to be able to detect DNA in future experiments." ; obo:IAO_0000116 """Need to find out if we consider labeled nucleotides still nucleotides. It is after consulting with ChEBI group. Added duirng Mar 1, 2010 dev call""" ; obo:IAO_0000117 "Group: OBI group" ; obo:IAO_0000119 "Group: OBI group" ; a owl:Class ; rdfs:label "labeled DNA extract" ; rdfs:subClassOf obo:OBI_0001143, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0600038 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:CHEBI_16991 ] . obo:OBI_0000909 obo:IAO_0000111 "cloacal specimen" ; obo:IAO_0000112 "type of sample used in the PCIRN influenza network" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 """A specimen obtained by inserting a swab deeply into the vent of the cloaca of an organism and vigorously swabbing the wall. The swab should be deeply stained with fecal material and is then placed in transport medium.""" ; obo:IAO_0000117 "PERSON: Melanie Courtot" ; obo:IAO_0000119 "WEB: http://www.wpro.who.int/NR/rdonlyres/EFD2B9A7-2265-4AD0-BC98-97937B4FA83C/0/manualonanimalaidiagnosisandsurveillance.pdf" ; a owl:Class ; rdfs:label "cloacal specimen" ; rdfs:subClassOf obo:OBI_0100051, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] . obo:OBI_0000910 obo:IAO_0000111 "radio immuno assay" ; obo:IAO_0000112 "To evaluate the specificity of antibody binding to 35S-labeled IA-2(256-760) in comparison with 35S-labeled IA-2IC construct, the mutual inhibition activity of different concentrations of unlabeled IA-2IC and/or IA-2(256-760) fragments were tested. Unlabeled recombinant IA-2(256-760) and/or IA-2IC (0.5-, 1-, 2-, and 4-fold the amount of 35S-labeled protein) were added to each tube and incubated overnight at 4C with patient sera. The following day, after incubation with radiolabeled 35 IA-2(256-760) or 35S IA-2IC proteins, samples were processed with the usual radioimmunoprecipitation assay." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay in which a radioactive labeled antigen or antibody is used to determine the interaction between an antigen and its receptor. This can be used to detect the presence of an antigen of interest in an input sample or determine the specificity of an input antibody." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "radio immuno assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002743 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001741 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001741 ] ) ] ] ) ] . obo:OBI_0000911 obo:IAO_0000111 "real time reverse-transcription polymerase chain reaction assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that uses a reverse transcription step (an RNA strand is reverse transcribed into its DNA complement using the enzyme reverse transcriptase) before a PCR assay." ; obo:IAO_0000117 "Bjoern Peters", "Melanie Courtot" ; obo:IAO_0000118 "RRT-PCR", "RT-rt PCR", "qRT-PCR" ; a owl:Class ; rdfs:label "real time reverse-transcription polymerase chain reaction assay" ; rdfs:subClassOf obo:OBI_0002692, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0600028 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000893 obo:OBI_0003368 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000030 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0010467 ] ] . obo:OBI_0000912 obo:IAO_0000111 "X-ray crystallography 3D molecular structure determination assay" ; obo:IAO_0000112 "Crystallizing an antibody:antigen complex, and recording the diffraction pattern of a synchrotron beam, and assembling the 3d complex structure based on homologous complexes." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A 3D molecular structure determination assay in which the diffraction of pattern of X-ray beams in a crystal of purified material entities is used to resolve the 3-dimensional structure of the material entity of interest." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "X-ray crystallography 3D molecular structure determination assay" ; rdfs:subClassOf obo:OBI_0003117, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001138 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001138 ] ) ] . obo:OBI_0000913 obo:IAO_0000111 "promoter activity detection by reporter gene assay" ; obo:IAO_0000112 "A T cell hybridoma in which the beta-galactosidase gene (lacZ) was inserted under the control of the IL-2 promoter, is detected by adding the X-gal substrate which when cleaved by lacZ results in detectable blue color." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay in which the activity of a promoter in a cell is monitored by using a reporter gene that was inserted in a genomic location under control of the promoter and whose expression can be easily detected based on qualities or functions of the gene." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "promoter activity detection by reporter gene assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CL_0000000 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0001046 ] ] . obo:OBI_0000914 obo:IAO_0000111 "nasopharyngeal aspirate specimen" ; obo:IAO_0000112 "type of sample used in the PCIRN influenza network" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 """A speciemn which derives from nasopharyngeal mucosa after aspiration.""" ; obo:IAO_0000117 "PERSON: Melanie Courtot" ; obo:IAO_0000119 "WEB: http://www.wpro.who.int/NR/rdonlyres/EFD2B9A7-2265-4AD0-BC98-97937B4FA83C/0/manualonanimalaidiagnosisandsurveillance.pdf" ; a owl:Class ; rdfs:label "nasopharyngeal aspirate specimen" ; rdfs:subClassOf obo:OBI_0100051, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] . obo:OBI_0000915 obo:IAO_0000111 "freezing storage" ; obo:IAO_0000112 "a fozen pellet used for later assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A storage process in temperature that maintenance the frozen status of the stored entities." ; obo:IAO_0000116 """2010/3/3 Alan Ruttenberg: There is a question of whether we should have a separate objective to \"prepare for maintenance\" 2014/2/3 OBI dev call: \"prepare for maintenance\" is a separate process. For example, 'freezing' and 'flash freezing' are defined and can be used to produce frozen material for storage. Updated both textual and logical definition. Both input and output material of freezing storage have quality frozen.""" ; obo:IAO_0000117 "Person: Alan Ruttenberg, Mathias Brochhausen" ; obo:IAO_0000119 "MO_481 frozen_storage"@en, "OBI" ; a owl:Class ; rdfs:label "freezing storage" ; rdfs:subClassOf obo:OBI_0302893, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001985 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001985 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000806 ] . obo:OBI_0000916 obo:IAO_0000111 "flow cytometry assay" ; obo:IAO_0000112 "Using a flow cytometer to quantitate the percent of CD3 positive cells in a population by labeling them with a FITC tagged anti-CD3 antibody." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay in which an input cell population is put in solution, is passed by a laser, and optical sensors are used to detect scattering of the laser light and/or fluorescence of specific markers to count and characterize the particles in solution." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000118 "FACS" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "flow cytometry assay" ; rdfs:subClassOf obo:OBI_0001977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001977 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400044 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400044 ] ) ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001501 obo:OBI_0003368 ) ] ] ) ] . obo:OBI_0000917 obo:IAO_0000111 "nasal swab specimen" ; obo:IAO_0000112 "type of sample used in the PCIRN influenza network" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 """A specimen obtained using a cotton swab on a stick, passed up the nostril to obtain a sample of exudate and epithelial debris for microbiological or cellular examination.""" ; obo:IAO_0000117 "PERSON: Melanie Courtot" ; obo:IAO_0000119 "WEB: http://www.wpro.who.int/NR/rdonlyres/EFD2B9A7-2265-4AD0-BC98-97937B4FA83C/0/manualonanimalaidiagnosisandsurveillance.pdf" ; a owl:Class ; rdfs:label "nasal swab specimen" ; rdfs:subClassOf obo:OBI_0002599, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] . obo:OBI_0000918 obo:IAO_0000111 "Dulbecco's modified Eagle medium" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A culture medium containing iron, phenol red, amino acids, salts, glucose and vitamins." ; obo:IAO_0000116 "Logical definition should contain all components listed in textual definition at some point." ; obo:IAO_0000117 "PERSON:Bjoern Peters" ; obo:IAO_0000118 "D-MEM", "DMEM" ; a owl:Class ; rdfs:label "Dulbecco's modified Eagle medium" ; rdfs:subClassOf obo:OBI_0000079, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:CHEBI_17234 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:CHEBI_33709 ] ) ] . obo:OBI_0000919 obo:IAO_0000111 "animal euthanization" ; obo:IAO_0000112 "Rats were euthanized with CO2" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A process in which is the end of life of animal is brought about in accordance with local regulations on treatment of animal subjects and using a method which causes minimal pain and distress to the animal subject" ; obo:IAO_0000117 "Helen Parkinson and Melissa Haendel" ; obo:IAO_0000118 "animal sacrifice" ; obo:IAO_0000119 "Melissa Haendel" ; a owl:Class ; rdfs:comment "may later be refined with more specific list of organisms" ; rdfs:label "animal euthanization" ; rdfs:subClassOf obo:OBI_0600006, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:NCBITaxon_7742 ] . obo:OBI_0000920 obo:IAO_0000111 "cytometric bead array assay" ; obo:IAO_0000112 "Using a Luminex machine to detect IFN-gamma and IL-10 in the supernatant of a cell culture." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay in which a series of beads coated with antibodies, antigens, or other small molecules are used to detect an analyte of interest." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000118 "Luminex assay" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "cytometric bead array assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_1000207 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_1000207 ] ) ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001501 obo:OBI_0003368 ) ] ] ) ] . obo:OBI_0000921 obo:IAO_0000111 "labeled RNA extract" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a labeled specimen that is the output of a labeling process and has grain labeled RNA to be able to detect RNA in future experiments." ; obo:IAO_0000116 """Need to find out if we consider labeled nucleotides still nucleotides. It is after consulting with ChEBI group. Added duirng Mar 1, 2010 dev call""" ; obo:IAO_0000117 "Group: OBI group" ; obo:IAO_0000119 "Group: OBI group" ; a owl:Class ; rdfs:label "labeled RNA extract" ; rdfs:subClassOf obo:OBI_0001143, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0600038 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000880 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:CHEBI_33697 ] . obo:OBI_0000922 obo:IAO_0000111 "frozen specimen" ; obo:IAO_0000112 "Frozen blood plasma" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A specimen that has been frozen in order to store it." ; obo:IAO_0000117 "Person:Alan Ruttenberg" ; obo:IAO_0000119 "MO_610 frozen_sample" ; a owl:Class ; rdfs:label "frozen specimen" ; rdfs:subClassOf obo:OBI_0001472 ; owl:disjointWith obo:OBI_0000950, obo:OBI_0000965, obo:OBI_0000971, obo:OBI_0000981 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000915 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] ) ] . obo:OBI_0000923 obo:IAO_0000111 "surface plasmon resonance binding assay" ; obo:IAO_0000112 "Running a Biacore instrument to measure the affinity, on and off rates of binding of a plate bound antibody to a antigen passing by in flow." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A binding assay that uses the detection of electromagnetic waves in a surface to detect material entities adsorbed to the surface, which change the local optical index of refraction." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "surface plasmon resonance binding assay" ; rdfs:subClassOf obo:OBI_0001146, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001136 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001136 ] ) ] . obo:OBI_0000924 obo:IAO_0000111 "labeled specimen" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A specimen that has been modified in order to be able to detect it in future experiments" ; obo:IAO_0000116 "added during call 3/1/2010" ; obo:IAO_0000117 "OBI group" ; a owl:Class ; rdfs:label "labeled specimen" ; rdfs:subClassOf obo:OBI_0000953, obo:OBI_0001936 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0002744 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600038 ] ) ] . obo:OBI_0000925 obo:IAO_0000111 "infectious agent" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is a material entity bearing the disposition to infect an organism"@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "infectious agent"@en ; rdfs:subClassOf obo:OBI_0100026 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:OBI_1110093 ] . obo:OBI_0000926 obo:IAO_0000111 "obsolete_ambidexterious handedness" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_ambidexterious handedness" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000927 obo:IAO_0000111 "lyophilization storage" ; obo:IAO_0000112 "" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a storage process with input material entity and output freeze dried material for long time storage" ; obo:IAO_0000117 "PERSON: Chris Stoeckert", "PERSON: Jie Zheng" ; obo:IAO_0000119 "" ; a owl:Class ; rdfs:comment "can link to freezing-dying equipment, such as freeze-dryer, rotary evaporator, if needed" ; rdfs:label "lyophilization storage" ; rdfs:subClassOf obo:OBI_0302893, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:BFO_0000040 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000806 ] . obo:OBI_0000928 obo:IAO_0000111 "material combination function" ; obo:IAO_0000112 "A stirrer has a material combination function" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A material separation function is a function that decreases the resolution between two or more material entities." ; obo:IAO_0000117 "Helen Parkinson" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "material combination function" ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000929 obo:IAO_0000111 "obsolete_training service provider role" ; obo:IAO_0000112 "EBI provides training on databases and tools and has a training service provider role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a service provider role which is realized by a servicer provider organization performing some training" ; obo:IAO_0000117 "PERSON:Helen Parkinson" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_training service provider role" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000930 obo:IAO_0000111 "calorimeter" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A measurement device that is used to calculate the heat flow of a chemical reaction or physical change." ; obo:IAO_0000117 "PERSON:Bjoern Peters" ; obo:IAO_0000118 "calorimetry instrument?" ; obo:IAO_0000119 "http://chemistry.about.com/od/chemistryglossary/a/calorimeterdef.htm" ; a owl:Class ; rdfs:label "calorimeter" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000931 obo:IAO_0000111 "study intervention" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process that is the part of the execution of an intervention design study which is varied between two or more subjects in the study." ; obo:IAO_0000117 "PERSON: Bjoern Peters" ; obo:IAO_0000119 "GROUP: OBI" ; a owl:Class ; rdfs:label "study intervention" ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100051 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0100051 ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000471 [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000059 ; owl:someValuesFrom obo:OBI_0000115 ] ] ) ] ] . obo:OBI_0000932 obo:IAO_0000111 "material separation device" ; obo:IAO_0000112 "flow cytometer" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A device with a separation function realized in a planed process" ; a owl:Class ; rdfs:label "material separation device" ; rdfs:subClassOf obo:OBI_0000968 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000968 [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000372 ] ) ] . obo:OBI_0000933 obo:IAO_0000111 "positron emission tomography scanner" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that produces a three-dimensional image or picture of functional processes in the body. It detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), which is introduced into the body on a biologically active molecule." ; obo:IAO_0000117 "PERSON:Bjoern Peters" ; obo:IAO_0000118 "PET scanner?" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Positron_emission_tomography" ; a owl:Class ; rdfs:label "positron emission tomography scanner" ; rdfs:subClassOf obo:OBI_0000398, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000397 ] . obo:OBI_0000934 obo:IAO_0000111 "intramuscular injection" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is the injection of a material entity (bearing the administered substance role) into the muscle (bearing the target role) of an organism using a syringe" ; a owl:Class ; rdfs:label "intramuscular injection" ; rdfs:subClassOf obo:OBI_0000426, obo:OBI_0600007 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000422 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0001134 ] ) ] ] ) ] . obo:OBI_0000935 obo:IAO_0000111 "micromanipulator" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to physically interact with a sample under a microscope, where a level of precision of movement is necessary that cannot be achieved by the unaided human hand." ; obo:IAO_0000117 "PERSON:Bjoern Peters" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Micromanipulator" ; a owl:Class ; rdfs:label "micromanipulator" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0000936 obo:IAO_0000111 "obsolete_material access provider role" ; obo:IAO_0000112 "A person or organization who provides access to a DNA sequencer." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a service provider role which is realized by a servicer provider organization performing access to some material" ; obo:IAO_0000117 "PERSON:Helen Parkinson" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_material access provider role" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000937 obo:IAO_0000111 "obsolete_left handedness" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:Class ; rdfs:label "obsolete_left handedness" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000938 obo:IAO_0000111 "categorical measurement datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A measurement datum that is reported on a categorical scale." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000118 "nominal mesurement datum" ; obo:IAO_0000119 "Bjoern Peters" ; a owl:Class ; rdfs:label "categorical measurement datum" ; rdfs:subClassOf obo:IAO_0000109, [ a owl:Restriction ; owl:onProperty obo:OBI_0001938 ; owl:someValuesFrom obo:OBI_0001930 ] . obo:OBI_0000939 obo:IAO_0000111 "training process" ; obo:IAO_0000112 "e.g. a training course run by a vendor on their instrument, a training service on a assay by a core facility" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a process that achieves a training objective" ; a owl:Class ; rdfs:label "training process" ; rdfs:subClassOf obo:OBI_0000011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000962 ] . obo:OBI_0000940 obo:IAO_0000111 "optical microscope" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A microscope that produces an image of an object by targeting it with an electro-magnetic beam in the visible frequency range" ; obo:IAO_0000117 "PERSON:Bjoern Peters" ; a owl:Class ; rdfs:label "optical microscope" ; rdfs:subClassOf obo:OBI_0400169 . obo:OBI_0000941 obo:IAO_0000111 "service consumer role" ; obo:IAO_0000112 "A biologist who uses a sequencing services fulfills the role of a service consumer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a role which inheres in a person who uses a service" ; obo:IAO_0000117 "Person:Helen Parkinson" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "service consumer role" ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:NCBITaxon_9606 obo:OBI_0000245 ) ] ] . obo:OBI_0000942 obo:IAO_0000111 "intradermal injection" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is the injection of a material entity (bearing the administered substance role) into the dermis (bearing the target role) of an organism using a syringe" ; obo:IAO_0000117 "PERSON: Melanie Courtot" ; a owl:Class ; rdfs:label "intradermal injection" ; rdfs:subClassOf obo:OBI_0000426, obo:OBI_0600007 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000422 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0002067 ] ) ] ] ) ] . obo:OBI_0000943 obo:IAO_0000111 "chemical cleavage" ; obo:IAO_0000112 """PMID: 20171258. Comparative reactivity of mismatched and unpaired bases in relation to their type and surroundings. Chemical cleavage of DNA mismatches in mutation detection analysis.Yakubovskaya MG, Belyakova AA, Gasanova VK, Belitsky GA, Dolinnaya NG. Biochimie. 2010 Feb 18.""" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "chemical cleavage is a protocol application relying on a chemical compound to cause the fragmentation of an input material that is susceptible to that chemical agent" ; obo:IAO_0000117 "PERSON:Philippe Rocca-Serra" ; obo:IAO_0000119 "RNA ontology group" ; a owl:Class ; rdfs:label "chemical cleavage" ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100051 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_23367 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000086 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0000944 obo:IAO_0000111 "handedness assay" ; obo:IAO_0000112 "The Edinburgh handedness assay is a specific method of determing handedness" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures the unequal distribution of fine motor skill between the left and right hands typically in human subjects by means of some questionnaire and scoring procedure." ; obo:IAO_0000117 "Helen Parkinson" ; obo:IAO_0000118 "handedness test" ; obo:IAO_0000119 "url:http://en.wikipedia.org/wiki/Handedness" ; a owl:Class ; rdfs:label "handedness assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PATO_0002201 ] ] . obo:OBI_0000945 obo:IAO_0000111 "vibration isolation table" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that supports another device such as a precision instrument by isolating it from vibration that is transmitted from the floor." ; obo:IAO_0000117 "PERSON:Bjoern Peters" ; obo:IAO_0000119 "United States Patent 6877711" ; a owl:Class ; rdfs:label "vibration isolation table" ; rdfs:subClassOf obo:OBI_0001034, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000401 ] . obo:OBI_0000946 obo:IAO_0000111 "sterilization function" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a function to remove viable organisms from an input material" ; a owl:Class ; rdfs:label "sterilization function" ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000947 obo:IAO_0000111 "service provider role" ; obo:IAO_0000112 "Jackson Lab provides experimental animals, EBI provides training on databases, a core facility provides access to a DNA sequencer." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is a role which inheres in a person or organization and is realized in in a planned process which provides access to training, materials or execution of protocols for an organization or person" ; obo:IAO_0000117 "PERSON:Helen Parkinson" ; a owl:Class ; rdfs:label "service provider role" ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:NCBITaxon_9606 obo:OBI_0000245 ) ] ], [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0000011 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0000948 obo:IAO_0000111 "oscilloscope" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that measures and displayes signal voltages, usually as a two-dimensional graph of one or more electrical potential differences (vertical axis) plotted as a function of time or of some other voltage (horizontal axis)." ; obo:IAO_0000117 "PERSON:Bjoern Peters" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Oscilloscope" ; a owl:Class ; rdfs:label "oscilloscope" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0000949 obo:IAO_0000111 "accessed material role" ; obo:IAO_0000112 "the role of the DNA sequencer to which someone gets access to a period of time, e.g. by payment, or other mechanism" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is realized in a planned process where the bearer participates" ; obo:IAO_0000116 "AR: rent a DNA sequencer for a period of time. two realizations, payment for the service and also when the person who pays for the service uses it" ; a owl:Class ; rdfs:label "accessed material role" ; rdfs:subClassOf obo:BFO_0000023 . obo:OBI_0000950 obo:IAO_0000111 "paraffin specimen" ; obo:IAO_0000112 "liver tissue embedded in paraffin" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a specimen that is output of a paraffin storage process in which specimen is embedded in paraffin" ; obo:IAO_0000117 "PERSON: Chris Stoeckert", "PERSON: Jie Zheng" ; obo:IAO_0000119 "MO_990 paraffin_sample" ; a owl:Class ; rdfs:label "paraffin specimen" ; rdfs:subClassOf obo:OBI_0001472 ; owl:disjointWith obo:OBI_0000965, obo:OBI_0000971, obo:OBI_0000981 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000977 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] ) ] . obo:OBI_0000951 obo:IAO_0000111 "compound treatment design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "an intervention design in which the treatment is the administration of a compound" ; obo:IAO_0000116 "This is meant to include all kinds of material administrations, including vaccinations, chemical compounds etc." ; obo:IAO_0000117 "PERSON: Bjoern Peters" ; obo:IAO_0000119 "MO_555 compound_treatment_design" ; a owl:Class ; rdfs:label "compound treatment design" ; rdfs:subClassOf obo:OBI_0000115, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000931 obo:OBI_0000995 ) ] ] ) ] ] . obo:OBI_0000952 obo:IAO_0000111 "oral administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administering substance in vivo into the mouth of an organism" ; obo:IAO_0000117 "PERSON: Melanie Courtot" ; a owl:Class ; rdfs:label "oral administration" ; rdfs:subClassOf obo:OBI_0600007 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0000165 ] ) ] ] ) ] . obo:OBI_0000953 obo:IAO_0000111 "processed specimen" ; obo:IAO_0000112 """A tissue sample that has been sliced and stained for a histology study. A blood specimen that has been centrifuged to obtain the white blood cells.""" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that has been intentionally physically modified." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "Bjoern Peters" ; a owl:Class ; rdfs:comment "A tissue sample that has been sliced and stained for a histology study." ; rdfs:label "processed specimen" ; rdfs:subClassOf obo:OBI_0000047, obo:OBI_0100051 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000047 obo:OBI_0100051 ) ] . obo:OBI_0000954 obo:IAO_0000111 "subcutaneous injection" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is the injection of a material entity (bearing the administered substance role) into the hypodermis (bearing the target role) of an organism using a syringe" ; obo:IAO_0000117 "PERSON: Melanie Courtot" ; a owl:Class ; rdfs:label "subcutaneous injection" ; rdfs:subClassOf obo:OBI_0000426, obo:OBI_0600007 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000422 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0002072 ] ) ] ] ) ] . obo:OBI_0000955 obo:IAO_0000111 "electrode puller" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device used in the first step in making electrodes, that applies constant tension on a glass capillary tube and eventually breaks it while heating it; this produces a very fine point on the capillary tube." ; obo:IAO_0000117 "PERSON:Bjoern Peters" ; obo:IAO_0000119 "http://faculty.plattsburgh.edu/donald.slish/Puller1.html" ; a owl:Class ; rdfs:label "electrode puller" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0000956 obo:IAO_0000111 "obsolete_handedness" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000228 ; obo:IAO_0100001 obo:PATO_0002201 ; a owl:Class ; rdfs:label "obsolete_handedness" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000957 obo:IAO_0000111 "self reported handedness assessment" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay where a person makes a statement that indicates what handedness he has from a choice of different categories." ; a owl:Class ; rdfs:label "self reported handedness assessment" ; rdfs:subClassOf obo:OBI_0000944, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000938 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PATO_0002201 ] ] . obo:OBI_0000958 obo:IAO_0000111 "right handed" ; obo:IAO_0000114 obo:IAO_0000123 ; a obo:OBI_0000963, owl:NamedIndividual ; rdfs:label "right handed" . obo:OBI_0000959 obo:IAO_0000111 "vibrotome" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A preparation device that uses a vibrating razor blade to cut through tissue." ; a owl:Class ; rdfs:label "vibrotome" ; rdfs:subClassOf obo:OBI_0000932, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000372 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0600014 ; owl:onProperty obo:BFO_0000054 ] ] . obo:OBI_0000960 obo:IAO_0000111 "reagent application function" ; obo:IAO_0000112 "An automatic tissue processor automatically applies antibodies and buffers to histological tissue preparations." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A function that is realized when a reagent is automatically added to some research material." ; obo:IAO_0000117 "PERSON: Nicole Vasilevsky, Matthew Brush" ; obo:IAO_0000119 "PERSON: Nicole Vasilevsky, Matthew Brush" ; obo:IAO_0000232 "4/10/2011: It is unclear if we need / want this, or what this is supposed to be for. Lots of the functions we have are reagent specific. Will this only confuse people?" ; a owl:Class ; rdfs:label "reagent application function" ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0000961 obo:IAO_0000111 "addition of molecular tracer function" ; obo:IAO_0000112 "Immunohistochemical labeling of tissue sections by an autostainer staining system." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A reagent application function that is realized when a molecular tracer, such as an antibody or probe is automatically transferred to a biological specimen." ; obo:IAO_0000117 "PERSON: Nicole Vasilevsky, Matthew Brush" ; obo:IAO_0000119 "PERSON: Nicole Vasilevsky, Matthew Brush" ; a owl:Class ; rdfs:label "addition of molecular tracer function" ; rdfs:subClassOf obo:OBI_0000960 . obo:OBI_0000962 obo:IAO_0000111 "training objective" ; obo:IAO_0000112 "A training objective is fulfilled by e.g. a bioconductor tutorial which instructs the user in the use of a package" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An objective specification which is fulfilled by the provision of some training." ; obo:IAO_0000117 "Helen Parkinson" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "training objective" ; rdfs:subClassOf obo:IAO_0000005 . obo:OBI_0000963 obo:IAO_0000111 "categorical label" ; obo:IAO_0000112 "The labels 'positive' vs. 'negative', or 'left handed', 'right handed', 'ambidexterous', or 'strongly binding', 'weakly binding' , 'not binding', or '+++', '++', '+', '-' etc. form scales of categorical labels." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A label that is part of a categorical datum and that indicates the value of the data item on the categorical scale." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "Bjoern Peters" ; a owl:Class ; rdfs:label "categorical label" ; rdfs:subClassOf obo:IAO_0000009 . obo:OBI_0000964 obo:IAO_0000111 "in live cell assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay in which a measurement is made by observing entities located in a live cell." ; a owl:Class ; rdfs:label "in live cell assay" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0000965 obo:IAO_0000111 "lyophilized specimen" ; obo:IAO_0000112 "freezing dried DNA" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a specimen that is output of a lyophilization storage process in which specimen is lyophilized for storage." ; obo:IAO_0000117 "PERSON: Chris Stoeckert", "PERSON: Jie Zheng" ; obo:IAO_0000119 "MO_589 freeze_dried_sample" ; a owl:Class ; rdfs:label "lyophilized specimen" ; rdfs:subClassOf obo:OBI_0001472 ; owl:disjointWith obo:OBI_0000971, obo:OBI_0000981 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000927 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] ) ] . obo:OBI_0000966 obo:IAO_0000111 "in live organism assay" ; obo:IAO_0000112 "Measuring the rate in which cells that are pulsed with a peptide are killed inside a mouse by peptide specific cytotoxic T cells." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay in which a measurement is made by observing entities located in an organism." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000118 "in vivo assay" ; a owl:Class ; rdfs:label "in live organism assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ) ] ] . obo:OBI_0000967 obo:IAO_0000111 "container" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A device that can be used to restrict the location of material entities over time" ; obo:IAO_0000116 "03/21/2010: Added to allow classification of children (similar to what we want to do for 'measurement device'. Lookint at what classifies here, we may want to reconsider a contain function assigned to a part of an entity is necessarily also a function of the whole (e.g. is a centrifuge a container because it has test tubes as parts?)" ; obo:IAO_0000117 "PERSON: Bjoern Peters" ; a owl:Class ; rdfs:label "container" ; rdfs:subClassOf obo:OBI_0000968 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000968 [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000370 ] ) ] . obo:OBI_0000968 obo:IAO_0000111 "device" ; obo:IAO_0000112 "A voltmeter is a measurement device which is intended to perform some measure function.", "An autoclave is a device that sterlizes instruments or contaminated waste by applying high temperature and pressure." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A material entity that is designed to perform a function in a scientific investigation, but is not a reagent." ; obo:IAO_0000116 """2012-12-17 JAO: In common lab usage, there is a distinction made between devices and reagents that is difficult to model. Therefore we have chosen to specifically exclude reagents from the definition of \"device\", and are enumerating the types of roles that a reagent can perform. 2013-6-5 MHB: The following clarifications are outcomes of the May 2013 Philly Workshop. Reagents are distinguished from devices that also participate in scientific techniques by the fact that reagents are chemical or biological in nature and necessarily participate in some chemical interaction or reaction during the realization of their experimental role. By contrast, devices do not participate in such chemical reactions/interactions. Note that there are cases where devices use reagent components during their operation, where the reagent-device distinction is less clear. For example: (1) An HPLC machine is considered a device, but has a column that holds a stationary phase resin as an operational component. This resin qualifies as a device if it participates purely in size exclusion, but bears a reagent role that is realized in the running of a column if it interacts electrostatically or chemically with the evaluant. The container the resin is in (“the column”) considered alone is a device. So the entire column as well as the entire HPLC machine are devices that have a reagent as an operating part. (2) A pH meter is a device, but its electrode component bears a reagent role in virtue of its interacting directly with the evaluant in execution of an assay. (3) A gel running box is a device that has a metallic lead as a component that participates in a chemical reaction with the running buffer when a charge is passed through it. This metallic lead is considered to have a reagent role as a component of this device realized in the running of a gel. In the examples above, a reagent is an operational component of a device, but the device itself does not realize a reagent role (as bearing a reagent role is not transitive across the part_of relation). In this way, the asserted disjointness between a reagent and device holds, as both roles are never realized in the same bearer during execution of an assay.""" ; obo:IAO_0000117 "PERSON: Helen Parkinson" ; obo:IAO_0000118 "instrument" ; obo:IAO_0000119 "OBI development call 2012-12-17." ; a owl:Class ; rdfs:label "device" ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000094 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:BFO_0000034 ] ; owl:disjointWith [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000086 ] ) ] . obo:OBI_0000969 obo:IAO_0000111 "dose specification" ; obo:IAO_0000112 "a protocol specifying to administer 1 ml of vaccine to a mouse" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a directive information entity that describes the dose that will be administered to a target" ; a owl:Class ; rdfs:label "dose specification" ; rdfs:subClassOf obo:IAO_0000033 . obo:OBI_0000970 obo:IAO_0000111 "scalar score from composite inputs" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A measurement datum which is the result of combining multiple datum. For example, a mean or summary score."@en ; obo:IAO_0000116 "JT: We included this because we wanted to talk about an output from a questionnaire that summarized the answers to the questionnaire, but which was not actually the answer to any single question."@en ; obo:IAO_0000117 "Person: Jessica Turner"@en ; obo:IAO_0000118 "questionaire score" ; obo:IAO_0000119 "Person: Jessica Turner"@en ; obo:IAO_0000232 "JZ: can we defined it logically as the output of some data transformation, like aggragate data transformation?"@en ; a owl:Class ; rdfs:label "scalar score from composite inputs" ; rdfs:subClassOf obo:IAO_0000032, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0200000 ], [ a owl:Restriction ; owl:minCardinality "1"^^xsd:nonNegativeInteger ; owl:onProperty obo:IAO_0000004 ] . obo:OBI_0000971 obo:IAO_0000111 "fresh specimen" ; obo:IAO_0000112 "a liver freshly removed from a rat" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a specimen that is output of a specimen creation process used for an investigation without storage." ; obo:IAO_0000117 "PERSON: Chris Stoeckert", "PERSON: Jie Zheng" ; obo:IAO_0000119 "MO_730 fresh_sample" ; a owl:Class ; rdfs:label "fresh specimen" ; rdfs:subClassOf obo:OBI_0001472 ; owl:disjointWith obo:OBI_0000981 . obo:OBI_0000972 obo:IAO_0000111 "obsolete_electrically powered device" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a processed material created to have a function and which requires electrical power to execute" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_electrically powered device" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000973 obo:IAO_0000111 "sequence data" ; obo:IAO_0000112 "example of usage: the representation of a nucleotide sequence in FASTA format used for a sequence similarity search." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A measurement datum that representing the primary structure of a macromolecule(it's sequence) sometimes associated with an indicator of confidence of that measurement." ; obo:IAO_0000117 "Person:Chris Stoeckert" ; obo:IAO_0000119 "GROUP: OBI" ; a owl:Class ; rdfs:label "sequence data"@en ; rdfs:subClassOf obo:IAO_0000109, [ a owl:Class ; owl:intersectionOf (obo:IAO_0000109 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:SO_0000001 ] ) ] . obo:OBI_0000974 obo:IAO_0000111 "obsolete_right handedness" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:Class ; rdfs:label "obsolete_right handedness" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000975 obo:IAO_0000111 "cell-cell binding detection by flow cytometry assay" ; obo:IAO_0000112 "Staining a B cell with PE and staining a T cell with FITC, incubating them together with a peptide, and counting the number of co-stained conjugates." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A binding assay which uses a flow cytometer to detect pairs of cells that are bound to each other by staining them with different fluorescent labels." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "cell-cell binding detection by flow cytometry assay" ; rdfs:subClassOf obo:OBI_0001977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001977 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 obo:OBI_0003368 ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001588 ] ] ) ] . obo:OBI_0000976 obo:IAO_0000111 "handedness categorical measurement datum" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A datum used to record the answer to a self assessment of whether a person uses their left hand, right hand primarily or each hand equally" ; obo:IAO_0000117 "PERSON:Alan Ruttenberg", "PERSON:Jessica Turner" ; a owl:Class ; rdfs:label "handedness categorical measurement datum" ; rdfs:subClassOf obo:OBI_0000938, [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:PATO_0002201 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000999 ; owl:someValuesFrom [ a owl:Class ; owl:oneOf (obo:OBI_0000958 obo:OBI_0000979 obo:OBI_0000998 ) ] ] . obo:OBI_0000977 obo:IAO_0000111 "paraffin storage" ; obo:IAO_0000112 "" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a storage process with input organism or anatomical entity and paraffin and output material embedded in paraffin for long term storage" ; obo:IAO_0000117 "PERSON: Chris Stoeckert", "PERSON: Jie Zheng" ; obo:IAO_0000119 "UPenn Group" ; a owl:Class ; rdfs:comment "need to specify paraffin or wax is one of specified input of the process" ; rdfs:label "paraffin storage" ; rdfs:subClassOf obo:OBI_0302893, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0100026 obo:UBERON_0000465 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000806 ] . obo:OBI_0000978 obo:IAO_0000111 "in container assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay in which a measurement is made by observing entities located in a container." ; a owl:Class ; rdfs:label "in container assay" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0000979 obo:IAO_0000111 "ambidexterous" ; obo:IAO_0000114 obo:IAO_0000123 ; a obo:OBI_0000963, owl:NamedIndividual ; rdfs:label "ambidexterous" . obo:OBI_0000980 obo:IAO_0000111 "obsolete_protocol service provider role" ; obo:IAO_0000112 "DNA sequencing of a sample by a core lab which returns data to the consumer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a service provider role which is realized by a servicer provider organization performing a protocol execution" ; obo:IAO_0000117 "PERSON:Helen Parkinson" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_protocol service provider role" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000981 obo:IAO_0000111 "agar stab specimen" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a specimen that is output of a process that cell culture inoculated into agar for long term storage." ; obo:IAO_0000117 "PERSON: Chris Stoeckert", "PERSON: Jie Zheng" ; obo:IAO_0000119 "MO_971 agar_stab" ; a owl:Class ; rdfs:label "agar stab specimen" ; rdfs:subClassOf obo:OBI_0001472 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001003 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] ] ) ] ] . obo:OBI_0000982 obo:IAO_0000111 "computed tomography scanner" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An image acquisition device that generates a three-dimensional image of the inside of an object from a large series of two-dimensional X-ray images taken around a single axis of rotation." ; obo:IAO_0000117 "PERSON:Bjoern Peters" ; obo:IAO_0000118 "CT scanner", "X-ray computed tomography scanner" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/X-ray_computed_tomography" ; a owl:Class ; rdfs:label "computed tomography scanner" ; rdfs:subClassOf obo:OBI_0000398, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000397 ] . obo:OBI_0000983 obo:IAO_0000111 "intranasal mucosal administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The administration of a substance into the intranasal mucosis of an organism" ; obo:IAO_0000117 "PERSON: Melanie Courtot" ; a owl:Class ; rdfs:label "intranasal mucosal administration" ; rdfs:subClassOf obo:OBI_0600007 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0005022 ] ) ] ] ) ] . obo:OBI_0000984 obo:IAO_0000111 "dose" ; obo:IAO_0000112 "An organism has been injected 1ml of vaccine" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A measurement datum that measures the quantity of something that may be administered to an organism or that an organism may be exposed to. Quantities of nutrients, drugs, vaccines and toxins are referred to as doses." ; a owl:Class ; rdfs:label "dose" ; rdfs:subClassOf obo:IAO_0000109 . obo:OBI_0000985 obo:IAO_0000111 "growth condition intervention design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which the independent variable is the environmental condition in which the specimen is growing" ; obo:IAO_0000117 "PERSON: Bjoern Peters" ; obo:IAO_0000119 "MO_588 growth_condition_design" ; a owl:Class ; rdfs:label "growth condition intervention design" ; rdfs:subClassOf obo:OBI_0000115, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000931 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000997 ] ) ] ] . obo:OBI_0000986 obo:IAO_0000111 "obsolete_DNA sequencing training service" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A training process with the objective to provide a trainee with the skill to run DNA sequencing experiments" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_DNA sequencing training service" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000987 obo:IAO_0000111 "obsolete_general scalar measurement datum" ; obo:IAO_0000114 obo:IAO_0000124 ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_general scalar measurement datum" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000988 obo:IAO_0000111 "obsolete performing a diagnosis" ; obo:IAO_0000112 "Diagnosing that a patient has pneumonia based on information on measurements of temperature, sound of breathing, and patient complaining about a headache." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The interpretation of the information available about bodily features (clinical picture) of a patient resulting in a diagnosis" ; obo:IAO_0000231 obo:IAO_0000103 ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/623" ; a owl:Class ; rdfs:label "obsolete performing a diagnosis" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0000989 obo:IAO_0000111 "PCR instrument" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A device that is used to amplify a single or few copies of a piece of DNA across several orders of magnitude, generating thousands to millions of copies of a particular DNA sequence." ; obo:IAO_0000116 "03/21/2010: Added because it is unclear if the thermal cycler definition is intentionally broader than PCR instrument. Contacted Melanie and Trish about this. Definitions and use of alternative terms need to be made consistent." ; a owl:Class ; rdfs:label "PCR instrument" ; rdfs:subClassOf obo:OBI_0400116, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0000415 ; owl:onProperty obo:BFO_0000054 ] ] . obo:OBI_0000990 obo:IAO_0000111 "electron microscope" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A microscope that produces an image of an object by targeting it with an electron beam" ; a owl:Class ; rdfs:label "electron microscope" ; rdfs:subClassOf obo:OBI_0400169 . obo:OBI_0000991 obo:IAO_0000111 "Edinburgh score" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A score that measures the dominance of a person's right or left hand in everyday activities." ; obo:IAO_0000117 "Person: Alan Ruttenberg", "Person:Jessica Turner" ; obo:IAO_0000119 "PMID:5146491#Oldfield, R.C. (1971). The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia, 9, 97-113", "WEB:http://www.cse.yorku.ca/course_archive/2006-07/W/4441/EdinburghInventory.html" ; a owl:Class ; rdfs:label "Edinburgh score" ; rdfs:subClassOf obo:OBI_0000970, [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:PATO_0002201 ], [ a owl:Restriction ; owl:minCardinality "1"^^xsd:nonNegativeInteger ; owl:onProperty obo:IAO_0000004 ] . obo:OBI_0000992 obo:IAO_0000111 "DNA sequencing service" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A DNA sequencing process provided as a service - which is the realization of some DNA sequencing in which the service provider role is realized." ; obo:IAO_0000116 "Eagle-i will supply better English definition" ; a owl:Class ; rdfs:label "DNA sequencing service" ; rdfs:subClassOf obo:OBI_0001904, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_0000941 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_0000947 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001904 [ a owl:Restriction ; owl:onProperty obo:OBI_0000107 ; owl:someValuesFrom obo:OBI_0000626 ] ) ] . obo:OBI_0000993 obo:IAO_0000111 "service provision objective" ; obo:IAO_0000112 "A sequencing centre has a service provision objective" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An objective which is fulfilled by the provision of some service e.g. a training service" ; obo:IAO_0000117 "Helen Parkinson" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "service provision objective" ; rdfs:subClassOf obo:IAO_0000005 . obo:OBI_0000994 obo:IAO_0000111 "intravenous injection" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is the injection of a material entity (bearing the administered substance role) into the vein (bearing the target role) of an organism using a syringe" ; obo:IAO_0000117 "PERSON: Melanie Courtot" ; a owl:Class ; rdfs:label "intravenous injection" ; rdfs:subClassOf obo:OBI_0000426, obo:OBI_0600007 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000422 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0001638 ] ) ] ] ) ] . obo:OBI_0000995 obo:IAO_0000111 "administration of material to specimen" ; obo:IAO_0000112 "Staining cells in a tissue slice with a dye." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The directed combination of a material entity with a specimen." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "Bjoern Peters" ; a owl:Class ; rdfs:label "administration of material to specimen" ; rdfs:subClassOf obo:OBI_0000274, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0100051 ] ) ] ] . obo:OBI_0000996 obo:IAO_0000111 "device creation objective" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "an objective which aims to create a device with a specified function" ; obo:IAO_0000117 "PERSON: Helen Parkinson" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "device creation objective" ; rdfs:subClassOf obo:OBI_0000456 . obo:OBI_0000997 obo:IAO_0000111 "growth environment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The collection of material entities and their qualities that are located near a live organism, tissue or cell and can influence its growth." ; obo:IAO_0000116 "Right now this may be incomplete. Should also cover e.g. sound, light as well." ; obo:IAO_0000117 "PERSON:Richard Scheuermann, Jie Zheng, Bjoern Peters" ; obo:IAO_0000119 "OBI group" ; a owl:Class ; rdfs:label "growth environment" ; rdfs:subClassOf obo:BFO_0000040 . obo:OBI_0000998 obo:IAO_0000111 "left handed" ; obo:IAO_0000114 obo:IAO_0000123 ; a obo:OBI_0000963, owl:NamedIndividual ; rdfs:label "left handed" . obo:OBI_0000999 obo:IAO_0000111 "has category label" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A relation between a categorical measurement data item and the categorical label that indicates the value of that data item on the categorical scale." ; a owl:ObjectProperty ; rdfs:domain obo:OBI_0000938 ; rdfs:label "has category label" ; rdfs:range obo:OBI_0000963 ; rdfs:subPropertyOf obo:BFO_0000051 . obo:OBI_0001000 obo:IAO_0000111 "questionnaire" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A document with a set of printed or written questions with a choice of answers, devised for the purposes of a survey or statistical study."@en ; obo:IAO_0000116 """JT: It plays a role in collecting data that could be fleshed out more; but I'm thinking it is, in itself, an edited document. JZ: based on textual definition of edited document, it can be defined as N&S. I prefer to leave questionnaire as a document now. We can add more restrictions in the future and use that to determine it is an edited document or not."""@en, "Need to clarify if this is a document or a directive information entity (or what their connection is))" ; obo:IAO_0000117 "PERSON: Jessica Turner"@en ; obo:IAO_0000119 "Merriam-Webster"@en ; a owl:Class ; rdfs:label "questionnaire" ; rdfs:subClassOf obo:IAO_0000310 . obo:OBI_0001001 obo:IAO_0000111 "Edinburgh handedness assay" ; obo:IAO_0000112 "Verdino (1998) Perceptual and Motor Skills. 86 (2): 476_8. (PMID: 9638746) uses this measure in an experimental study: \"Individuals of extreme handedness based on the Edinburgh Handedness Inventory (laterality Quotients of +90 to +100 and -100 and +54; 50 each)\"" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that uses a set of questions (the Edinburgh Handedness inventory) to generate a score that can be used to assess the dominance of a person's right or left hand in everyday activities. The inventory can be used by an observer assessing the person, or by a person self-reporting hand use. The latter method tends to be less reliable due to a person over-attributing tasks to the dominant hand." ; obo:IAO_0000117 "Alan Ruttenberg", "Gully Burns (orcid:0000-0003-1493-865X)", "Jessica Turner" ; obo:IAO_0000119 "PMID:5146491", "url:http://en.wikipedia.org/wiki/Edinburgh_Handedness_Inventory" ; a owl:Class ; rdfs:label "Edinburgh handedness assay" ; rdfs:subClassOf obo:OBI_0000944, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_9606 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000991 ], [ a owl:Restriction ; owl:hasValue obo:OBI_0001004 ; owl:onProperty obo:OBI_0000293 ] . obo:OBI_0001002 obo:IAO_0000111 "Faraday cage" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device formed by conducting material or by a mesh of such material, that blocks out external static electric fields." ; obo:IAO_0000117 "PERSON:Bjoern Peters" ; obo:IAO_0000118 "Faraday shield" ; obo:IAO_0000119 "Wikipedia http://en.wikipedia.org/wiki/Faraday_cage" ; obo:IAO_0000232 "isolation function? HP" ; a owl:Class ; rdfs:label "Faraday cage" ; rdfs:subClassOf obo:OBI_0001034, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000401 ] . obo:OBI_0001003 obo:IAO_0000111 "agar stab storage" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a storage process with input cell culture and agar and output agar stab for long time storage" ; obo:IAO_0000117 "PERSON: Chris Stoeckert", "PERSON: Jie Zheng" ; obo:IAO_0000119 "UPenn Group" ; a owl:Class ; rdfs:comment "need to specify that agar is one of input for this process" ; rdfs:label "agar stab storage" ; rdfs:subClassOf obo:OBI_0302893, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100060 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000806 ] . obo:OBI_0001004 obo:IAO_0000111 "Edingburgh handedness inventory" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The Edinburgh Handedness Inventory is a set of questions used to assess the dominance of a person's right or left hand in everyday activities."@en ; obo:IAO_0000117 "PERSON:Alan Ruttenberg", "PERSON:Jessica Turner" ; obo:IAO_0000119 "PMID:5146491#Oldfield, R.C. (1971). The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia, 9, 97-113", "WEB:http://www.cse.yorku.ca/course_archive/2006-07/W/4441/EdinburghInventory.html" ; a obo:OBI_0001000, owl:NamedIndividual ; rdfs:label "Edingburgh handedness inventory" . obo:OBI_0001005 obo:IAO_0000111 "RNASE CL3 structure mapping assay" ; obo:IAO_0000112 "PMID:16453415" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using RNAse CL3 as reagent and enzymatic probe." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "single nucleotide resolution mapping assay using RNAse CL3" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "RNASE CL3 structure mapping assay" ; rdfs:subClassOf obo:OBI_0001014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000880 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000880 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000025478 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000025478 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000896 ] ] . obo:OBI_0001006 obo:IAO_0000111 "CMCT structure mapping assay" ; obo:IAO_0000112 "PMID:2422386 and PMID:2446263" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution nucleic acid structure mapping assay which uses CMCT as reagent and chemical probe to generate data and information at nucleotide resolution scale contributing to the determination of nucleic acid secondary structure" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "single nucleotide resolution mapping assay using CMCT probe" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "CMCT structure mapping assay" ; rdfs:subClassOf obo:OBI_0001017, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:CHEBI_16991 obo:CHEBI_33697 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000885 ] ] . obo:OBI_0001007 obo:IAO_0000111 "image acquisition" ; obo:IAO_0000112 "Taking a polaroid picture of a patients skin lesion; Using a digital camera to take a picture of a gel" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A planned process that captures an image of an object." ; obo:IAO_0000117 "PERSON: Jie Zheng" ; obo:IAO_0000118 "image acquisition" ; a owl:Class ; rdfs:label "image creation" ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:BFO_0000040 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000101 ] . obo:OBI_0001008 obo:IAO_0000111 "MPE-Fe(II) structure mapping assay" ; obo:IAO_0000112 "PMID:6209709" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at the nucleotide resolution scale using Fe-MP as reagent and chemical probe." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "single nucleotide resolution mapping assay using Fe-MP probe" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "MPE-Fe(II) structure mapping assay" ; rdfs:subClassOf obo:OBI_0001017, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000880 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000896 ] ] . obo:OBI_0001009 obo:IAO_0000111 "obsolete_qualitative binding detection assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A binding assay where the specified output determines if two or more material entities do or do not have the disposition to form a complex above a threshold level of significance. The threshold can be defined through detection limits of the instrument, the use of experimental controls that establish what is considered significant binding, or a predefined cutoff based on what binding is considered significant in a certain context." ; obo:IAO_0000117 "PERSON: Bjoern Peters, Randi Vita, Jason Greenbaum" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_qualitative binding detection assay" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0001010 obo:IAO_0000111 "nucleic acid extract" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An extract that is the output of an extraction process in which nucleic acid molecules are isolated from a specimen." ; obo:IAO_0000117 "PERSON: Jie Zheng" ; obo:IAO_0000119 "UPenn Group" ; a owl:Class ; rdfs:label "nucleic acid extract" ; rdfs:subClassOf obo:OBI_0000423, obo:OBI_0000953, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0666667 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:CHEBI_33696 ] . obo:OBI_0001011 obo:IAO_0000111 "ENU structure mapping assay" ; obo:IAO_0000112 "PMID:7002606 and PMID:2446263" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution nucleic acid structure mapping assay that determines the secondary structure of a nucleic acid at the nucleotide resolution scale which uses ENU as reagent and chemical probe" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "single nucleotide resolution mapping assay using ENU probe" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "ENU structure mapping assay" ; rdfs:subClassOf obo:OBI_0001017, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:CHEBI_16991 obo:CHEBI_33697 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000896 ] ] . obo:OBI_0001012 obo:IAO_0000111 "RNASE V1 structure mapping assay" ; obo:IAO_0000112 "PMID:7031604" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using RNAse V1 as reagent and enzymatic probe" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "single nucleotide resolution mapping assay using RNAse V1" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "RNASE V1 structure mapping assay" ; rdfs:subClassOf obo:OBI_0001014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000880 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000880 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000025477 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000025477 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000896 ] . obo:OBI_0001013 obo:IAO_0000111 "kethoxal structure mapping assay" ; obo:IAO_0000112 "single nucleotide resolution mapping assay using Kethoxal probe" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution nucleic acid structure mapping assay that determines nucleic acid secondary structure at nucleotide resolution scale using kethoxal as reagent and chemical probe" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "kethoxal structure mapping assay" ; rdfs:subClassOf obo:OBI_0001017, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:CHEBI_16991 obo:CHEBI_33697 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000885 ] ] . obo:OBI_0001014 obo:IAO_0000111 "single-nucleotide-resolution nucleic acid structure mapping assay using enzymatic probing" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution nucleic acid structure mapping assay that determines structural information about the RNA species under study using proteins acting as enzymatic probes." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "RNAO and OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/808" ; a owl:Class ; rdfs:label "single-nucleotide-resolution nucleic acid structure mapping assay using enzymatic probing" ; rdfs:subClassOf obo:OBI_0000870 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000870 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000427 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000427 ] ) ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000885 ] ] ) ] . obo:OBI_0001015 obo:IAO_0000111 "DMS structure mapping assay" ; obo:IAO_0000112 "PMID:6159633 and PMID:2446263" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution nucleic acid structure mapping assay which determins nucleic acid secondary structure at a nucleotide resolution scale using DMS as reagent and chemical probe" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "single nucleotide resolution mapping assay using DMS probe" ; obo:IAO_0000119 "RNA Ontology" ; a owl:Class ; rdfs:label "DMS structure mapping assay" ; rdfs:subClassOf obo:OBI_0001017, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:CHEBI_16991 obo:CHEBI_33697 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000885 ] ] . obo:OBI_0001016 obo:IAO_0000111 "DNASE 1 structure mapping assay" ; obo:IAO_0000112 "PMID:3773731" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution deoxyribonucleic acid structure mapping assay which uses DNAse 1 as reagent and enzymatic probe to generate data and information at nucleotide resolution scale contributing to the determination of nucleic acid secondary structure" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "DNAse footprinting assay", "single nucleotide resolution mapping assay using DNAse I" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "DNASE 1 structure mapping assay" ; rdfs:subClassOf obo:OBI_0001014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000880 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000880 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000006592 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000006592 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000885 ] ] . obo:OBI_0001017 obo:IAO_0000111 "single-nucleotide-resolution nucleic acid structure mapping assay using chemical probing" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution nucleic acid structure mapping assay that determines structural information about the RNA species under study using small chemical compounds acting as chemical probes." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "RNAO and OBI" ; a owl:Class ; rdfs:label "single-nucleotide-resolution nucleic acid structure mapping assay using chemical probing" ; rdfs:subClassOf obo:OBI_0000870 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000870 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_23367 [ a owl:Class ; owl:complementOf obo:OBI_0000427 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_23367 [ a owl:Class ; owl:complementOf obo:OBI_0000427 ] ) ] ] ) ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000885 ] ] ) ] . obo:OBI_0001018 obo:IAO_0000111 "Rhodium DNA structure mapping assay" ; obo:IAO_0000112 "PMID:2843807" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution nucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using Rhodium as reagent and chemical probe." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "single nucleotide resolution mapping assay using Rhodium probe" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "Rhodium DNA structure mapping assay" ; rdfs:subClassOf obo:OBI_0001017, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:CHEBI_16991 obo:CHEBI_33697 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000885 ] ] . obo:OBI_0001019 obo:IAO_0000111 "RNA ADA I RNA structure mapping assay" ; obo:IAO_0000112 "PMID:7527340" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using RNA adenosine deaminase I as reagent and enzymatic probe." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "single nucleotide resolution mapping assay using RNA adenosine deaminase I" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "RNA ADA I RNA structure mapping assay" ; rdfs:subClassOf obo:OBI_0001014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000880 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000880 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003745 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003745 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000896 ] ] . obo:OBI_0001020 obo:IAO_0000111 "Lead structure mapping assay" ; obo:IAO_0000112 "PMID:2686708" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution nucleic acid structure mapping assay that determines nucleic acid secondary structure at nucleotide resolution scale using lead as reagent and chemical probe" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "single nucleotide resolution mapping assay using Lead probe" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "Lead structure mapping assay" ; rdfs:subClassOf obo:OBI_0001017, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:CHEBI_16991 obo:CHEBI_33697 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000885 ] ] . obo:OBI_0001021 obo:IAO_0000111 "RNASE T2 structure mapping assay" ; obo:IAO_0000112 "PMID:6207483" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using RNAse T2 as reagent and enzymatic probe" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "single nucleotide resolution mapping assay using RNAse T2" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "RNASE T2 structure mapping assay" ; rdfs:subClassOf obo:OBI_0001014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000880 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000880 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000014060 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000014060 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000896 ] ] . obo:OBI_0001022 obo:IAO_0000111 "gene dosage assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures changes in phenotype due to increased or decreased dosage of a single allele of a gene." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "David Osumi Sutherland" ; a owl:Class ; rdfs:label "gene dosage assay" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0001023 obo:IAO_0000111 "Fe-BABE RNA structure mapping assay" ; obo:IAO_0000112 "PMID: 7862644" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic secondary structure at a nucleotide resolution scale using Fe-BABE as reagent and chemical probe." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "single nucleotide resolution mapping assay using Fe-BABE probe" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "Fe-BABE RNA structure mapping assay" ; rdfs:subClassOf obo:OBI_0001017, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000880 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000896 ] ] . obo:OBI_0001024 obo:IAO_0000111 "RNASE U2 structure mapping assay" ; obo:IAO_0000112 "PMID:409999" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using RNAase U2 as reagent and enzymatic probe" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "single nucleotide resolution mapping assay using RNAse U2" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "RNASE U2 structure mapping assay" ; rdfs:subClassOf obo:OBI_0001014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000880 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000880 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000025475 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000025475 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000896 ] ] . obo:OBI_0001025 obo:IAO_0000111 "binding constant determination assay" ; obo:IAO_0000112 "Determination of KD value for an antibody binding a protein using a BIACORE assay." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A binding assay where the specified output is a binding constant" ; obo:IAO_0000117 "Bjoern Peters", "Jason Greenbaum", "Randi Vita" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "binding constant determination assay" ; rdfs:subClassOf obo:OBI_0001146, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001144 ] . obo:OBI_0001026 obo:IAO_0000111 "NMIA RNA structure mapping assay" ; obo:IAO_0000112 "PMID: 15796531" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at the nucleotide resolution scale using NMIA as reagent and chemical probe" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "SHAPE mapping assay", "single nucleotide resolution mapping assay using NMIA probe" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "NMIA RNA structure mapping assay" ; rdfs:subClassOf obo:OBI_0001017, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000880 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000896 ] ] . obo:OBI_0001027 obo:IAO_0000111 "Terbium RNA structure mapping assay" ; obo:IAO_0000112 "PMID:10772868" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution nucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using Terbium as reagent and chemical probe" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "single nucleotide resolution mapping assay using Terbium probe" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "Terbium RNA structure mapping assay" ; rdfs:subClassOf obo:OBI_0001017, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000880 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000896 ] ] . obo:OBI_0001028 obo:IAO_0000111 "feature extraction" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A planed process with objective of obtaining quantified values from an image." ; obo:IAO_0000117 "PERSON: Jie Zheng" ; obo:IAO_0000119 "MO_928: feature_extraction" ; a owl:Class ; rdfs:comment "" ; rdfs:label "feature extraction" ; rdfs:subClassOf obo:OBI_0200000, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:IAO_0000101 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000027 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200005 ] . obo:OBI_0001029 obo:IAO_0000111 "OH-radical structure mapping assay" ; obo:IAO_0000112 "PMID:2501870" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution nucleic acid structure mapping assay hat determines nucleic acid secondary structure at a nucleotide resolution scale using hydroxyl radical as reagent and chemical probe" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "MOHCA assay", "OH footprinting assay", "single nucleotide resolution mapping assay using OH-radical probe" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "OH-radical structure mapping assay" ; rdfs:subClassOf obo:OBI_0001017, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:CHEBI_16991 obo:CHEBI_33697 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000885 ] ] . obo:OBI_0001030 obo:IAO_0000111 "RNASE T1 structure mapping assay" ; obo:IAO_0000112 "PMID:114514" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale uses RNAse T1 as reagent and enzymatic probe." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "single nucleotide resolution mapping assay using RNAse T1" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "RNASE T1 structure mapping assay" ; rdfs:subClassOf obo:OBI_0001014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000880 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000880 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000025467 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000025467 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000896 ] ] . obo:OBI_0001031 obo:IAO_0000111 "array image acquisition" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An image creation process that generate an image from the array." ; obo:IAO_0000117 "PERSON: Jie Zheng" ; obo:IAO_0000118 "array image acquisition" ; obo:IAO_0000119 "MO_929: image_acquisition" ; a owl:Class ; rdfs:label "array image creation" ; rdfs:subClassOf obo:OBI_0001007, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400147 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000101 ] . obo:OBI_0001032 obo:IAO_0000111 "light emission device" ; obo:IAO_0000112 "A light source is an optical subsystem that provides light for use in a distant area using a delivery system (e.g., fiber optics)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device which has a function to emit light." ; obo:IAO_0000117 "Person:Helen Parkinson" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "light emission device" ; rdfs:subClassOf obo:OBI_0000968 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000968 [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000367 ] ) ] . obo:OBI_0001033 obo:IAO_0000111 "perturbation device" ; obo:IAO_0000112 "", "A homogenizer is a perturbation device." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A perturbation device is a device which is designed to perform a perturb function" ; obo:IAO_0000117 "Helen Parkinson" ; obo:IAO_0000119 "OBI Vancouver workshop 2010", "PERSON: Helen Parkinson" ; a owl:Class ; rdfs:label "perturbation device" ; rdfs:subClassOf obo:OBI_0000968 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000968 [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000377 ] ) ] . obo:OBI_0001034 obo:IAO_0000111 "environmental control device" ; obo:IAO_0000112 "A growth chamber is an environmental control device." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An environmental control device is a device which has the function to control some aspect of the environment such as temperature, or humidity." ; obo:IAO_0000117 "Helen Parkinson" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "environmental control device" ; rdfs:subClassOf obo:OBI_0000968 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000968 [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0000371 obo:OBI_0000387 obo:OBI_0000401 ) ] ] ) ] . obo:OBI_0001035 obo:IAO_0000111 "Nuclease S1 structure mapping assay" ; obo:IAO_0000112 "PMID:363143" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution deoxyribonucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using DNAse 1 as reagent and enzymatic probe." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "single nucleotide resolution mapping assay using Nuclease S1" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "Nuclease S1 structure mapping assay" ; rdfs:subClassOf obo:OBI_0001014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000880 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000880 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000025471 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000025471 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000885 ] ] . obo:OBI_0001036 obo:IAO_0000111 "specimen fixation function" ; obo:IAO_0000112 "e.g the function of a bar code reader used to read slide bar codes" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a function that allows specific identification of individual speciment from one another." ; obo:IAO_0000117 "EAGLE-I" ; a owl:Class ; rdfs:label "specimen fixation function" ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0001037 obo:IAO_0000111 "obsolete_specimen fixation function" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A specimen fixation function is a function that holds or fastens an entity in a fixed position." ; obo:IAO_0000117 "EAGLE-I" ; obo:IAO_0000231 obo:IAO_0000227 ; a owl:Class ; rdfs:label "obsolete_specimen fixation function" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0001038 obo:IAO_0000111 "Ruthenium structure mapping assay" ; obo:IAO_0000112 "PMID:3016894" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution nucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using Rhutenium as reagent and chemical probe" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "RNA Ontology" ; a owl:Class ; rdfs:label "Ruthenium structure mapping assay" ; rdfs:subClassOf obo:OBI_0001017, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:CHEBI_16991 obo:CHEBI_33697 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000896 ] ] . obo:OBI_0001039 obo:IAO_0000111 "inline probing RNA structure mapping assay" ; obo:IAO_0000112 "PMID:10573122 and PMID: 18369975" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at nucleotide resolution scale using intromolecular reactivity" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "RNA ontology" ; a owl:Class ; rdfs:label "inline probing RNA structure mapping assay" ; rdfs:subClassOf obo:OBI_0001017, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000880 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000896 ] ] . obo:OBI_0001040 obo:IAO_0000111 "current amplification function" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A current amplification function is an amplification function that increases the amplitude of a current." ; obo:IAO_0000117 "EAGLE-I" ; a owl:Class ; rdfs:label "current amplification function" ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0001041 obo:IAO_0000111 "stabilization function" ; obo:IAO_0000112 "" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A stabilization function is a function that holds or isolates an entity such as an instrument or specimen steadfast or at an unfluctuating level or quantity." ; obo:IAO_0000117 "EAGLE-I" ; obo:IAO_0000118 "isolation function" ; a owl:Class ; rdfs:label "stabilization function" ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0001042 obo:IAO_0000111 "pump function" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a transfer unction where the transfer requires work to move the entity, often against a gradient." ; obo:IAO_0000117 "EAGLE-I" ; a owl:Class ; rdfs:label "pump function" ; rdfs:subClassOf obo:OBI_0000383 . obo:OBI_0001043 obo:IAO_0000111 "cell transfer function" ; obo:IAO_0000112 "A cell harvester has a cell transfer function." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is a transfer function that displaces cells from one place to another" ; obo:IAO_0000117 "EAGLE-I" ; a owl:Class ; rdfs:label "cell transfer function" ; rdfs:subClassOf obo:OBI_0000383 . obo:OBI_0001044 obo:IAO_0000111 "angiograph" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that records the patterns of pulse waves inside blood vessels." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://medical-dictionary.thefreedictionary.com/angiograph" ; a owl:Class ; rdfs:label "angiograph" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000368 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001045 obo:IAO_0000111 "capillary blotter" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to transfer nucleic acids from agarose gels onto a membrane, based on the movement of buffer from a reservoir through the gel and the blotting membrane to a stack of dry blotting paper by capillary force. The molecules are carried to the blotting membrane on which they are adsorbed." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://www.biometra.de/" ; a owl:Class ; rdfs:label "capillary blotter" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000383 ] . obo:OBI_0001046 obo:IAO_0000111 "bioreactor" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device or system that supports a biologically active environment." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Bioreactor" ; a owl:Class ; rdfs:label "bioreactor" ; rdfs:subClassOf obo:OBI_0001034, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000401 ] . obo:OBI_0001047 obo:IAO_0000111 "pH meter" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to measure the pH (acidity or alkalinity) of a liquid." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/PH_meter" ; a owl:Class ; rdfs:label "pH meter" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001048 obo:IAO_0000111 "digital camera" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An image acquisition device that takes video or still photographs, or both, digitally by recording images via an electronic image sensor." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Digital_camera" ; a owl:Class ; rdfs:label "digital camera" ; rdfs:subClassOf obo:OBI_0000398, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000397 ] . obo:OBI_0001049 obo:IAO_0000111 "chip spotting device" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device for dropping and immobilizing a solution of biomolecules, for example, nucleic acids such as probe DNA, mRNA, and peptide nucleic acid (PNA), and proteins on a DNA microarray surface to manufacture a DNA microarray." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "United States Patent 7416705" ; a owl:Class ; rdfs:label "chip spotting device" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000383 ] . obo:OBI_0001050 obo:IAO_0000111 "RNA extraction/purification instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to isolate and collect RNA for subsequent molecular analysis." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "RNA extraction/purification instrument" ; rdfs:subClassOf obo:OBI_0001114 . obo:OBI_0001051 obo:IAO_0000111 "DNA extract" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The output of an extraction process in which DNA molecules are purified in order to exclude DNA from organellas." ; obo:IAO_0000117 "Person: Jie Zheng" ; obo:IAO_0000119 "Group: UPenn group" ; a owl:Class ; rdfs:label "DNA extract" ; rdfs:subClassOf obo:OBI_0001010, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000257 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:CHEBI_16991 ] . obo:OBI_0001052 obo:IAO_0000111 "two-photon laser/detector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A light source used in fluorescence imaging that allows the imaging of living tissue up to a depth of 1 mm, based on the concept that two photons of low energy can excite a fluorophore in a quantum event, resulting in the emission of a fluorescence photon, typically at a higher energy than either of the two excitatory photons." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Two-photon_excitation_microscopy" ; a owl:Class ; rdfs:label "two-photon laser/detector" ; rdfs:subClassOf obo:OBI_0400065 . obo:OBI_0001053 obo:IAO_0000111 "electrophoresis system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that moves charged particles through a medium by using an electric field induced by electrodes." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Category:Electrophoresis" ; a owl:Class ; rdfs:label "electrophoresis system" ; rdfs:subClassOf obo:OBI_0000932, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000372 ] . obo:OBI_0001054 obo:IAO_0000111 "PET synthesizer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to produce targeted molecular pharmaceuticals for use in positron emission tomography." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "PET synthesizer" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000376 ] . obo:OBI_0001055 obo:IAO_0000111 "spinning-disk confocal microscope" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A confocal microscope that uses a Nipkow disk, a mechanical, geometrically operating image scanning device." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Nipkow_disk" ; a owl:Class ; rdfs:label "spinning-disk confocal microscope" ; rdfs:subClassOf obo:OBI_0001079, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001056 obo:IAO_0000111 "DNA synthesizer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An oligonucleotide synthesizer that is used to custom-build DNA molecules to contain a particular sequence of nucleotides." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://www.globalspec.com/LearnMore/Labware_Scientific_Instruments/Clinical_Research_Labware/DNA_Synthesizers" ; a owl:Class ; rdfs:label "DNA synthesizer" ; rdfs:subClassOf obo:OBI_0400113 . obo:OBI_0001057 obo:IAO_0000111 "high performance liquid chromatography instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A liquid chromatography instrument that consists of a reservoir of mobile phase, a pump, an injector, a separation column, and a detector. The pump (rather than gravity) provides the higher pressure required to propel the mobile phase and analyte through the densely packed column." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/High_performance_liquid_chromatography" ; a owl:Class ; rdfs:label "high performance liquid chromatography instrument" ; rdfs:subClassOf obo:OBI_0001139 . obo:OBI_0001058 obo:IAO_0000111 "microplate reader" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A measurement device that detects biological, chemical or physical events of samples in microtiter plates." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Plate_reader" ; a owl:Class ; rdfs:label "microplate reader" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001059 obo:IAO_0000111 "ELISA microplate reader" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A microplate reader that is used for enzyme-linked immunosorbent assays (ELISA)." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "ELISA microplate reader" ; rdfs:subClassOf obo:OBI_0001058 . obo:OBI_0001060 obo:IAO_0000111 "spot cutter" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A robotic device that is used to excise spots from gels." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "spot cutter" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0001061 obo:IAO_0000111 "microwave synthesis system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to apply microwave irradiation to chemical reactions." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Microwave_chemistry" ; a owl:Class ; rdfs:label "microwave synthesis system" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000374 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000376 ] . obo:OBI_0001062 obo:IAO_0000111 "densitometer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that measures the degree of darkness (the optical density) of a photographic or semitransparent material or of a reflecting surface." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Densitometer" ; a owl:Class ; rdfs:label "densitometer" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001063 obo:IAO_0000111 "automatic staining machine" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to automatically stain tissue sections on slides or tissue specimens." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "automatic staining machine" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000961 ] . obo:OBI_0001064 obo:IAO_0000111 "automatic tissue processor" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device for processing histological tissue having a tissue carrier basket suspended from a turntable overlying a plurality of beakers suspended from a carrier plate. The turntable is raised, indexed, and lowered by a suitable driving mechanism to move the tissue basket sequentially through the beakers. Timers can each be programmed to control the movement of the turntable to provide various different cycles for processing the tissue. Some of the beakers are received in individual thermal baths to heat and control the temperature of the substances received in the beakers for treating the tissue." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "United States Patent 3762362" ; a owl:Class ; rdfs:label "automatic tissue processor" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000960 ] . obo:OBI_0001065 obo:IAO_0000111 "stereo microscope" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An optical microscope that uses two separate optical paths with two objectives and two eyepieces to provide slightly different viewing angles to the left and right eyes." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Optical_microscope#Stereo_microscope" ; a owl:Class ; rdfs:label "stereo microscope" ; rdfs:subClassOf obo:OBI_0000940, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001066 obo:IAO_0000111 "top loading balance" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A balance that consists of a metal plate on which to place an object and a digital readout of the measurement of its mass." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "top loading balance" ; rdfs:subClassOf obo:OBI_0001135 . obo:OBI_0001067 obo:IAO_0000111 "perfusion station" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device or system in which perfusion units are integrated." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "perfusion station" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0001036 ] . obo:OBI_0001068 obo:IAO_0000111 "SPECT scanner" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A nuclear medicine tomographic imaging device that uses gamma rays to provide 3D information, typically presented as cross-sectional slices through the specimen but with the ability to be freely reformatted or manipulated as required." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Single_photon_emission_computed_tomography" ; a owl:Class ; rdfs:label "SPECT scanner" ; rdfs:subClassOf obo:OBI_0000398, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000397 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001069 obo:IAO_0000111 "array manufacturer role"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a manufacturer role which is played by the person or organization that manufactured the array" ; obo:IAO_0000117 "PERSON: Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "MO_695 array_manufacturer"@en ; a owl:Class ; rdfs:label "array manufacturer role"@en ; rdfs:subClassOf obo:OBI_0000571, [ a owl:Restriction ; owl:allValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000457 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0400147 ] ) ] ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_0001070 obo:IAO_0000111 "scintillation counter" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to measure ionizing radiation." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Scintillation_counter" ; a owl:Class ; rdfs:label "scintillation counter" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001071 obo:IAO_0000111 "programmable array microscope" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A confocal microscope that uses a programmable spatial light modulator for generating an arbitrary pattern of conjugate illumination and detection apertures." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "Verveer et al, Journal of Microscopy, vol. 189, pt. 3, pp. 192-8" ; a owl:Class ; rdfs:label "programmable array microscope" ; rdfs:subClassOf obo:OBI_0001079, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001072 obo:IAO_0000111 "cryostat" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device consisting of a vessel, similar in construction to a vacuum flask, that is used to maintain cold cryogenic temperatures. FIX THIS DEFINITION" ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Cryostat" ; a owl:Class ; rdfs:label "cryostat" ; rdfs:subClassOf obo:OBI_0000967, obo:OBI_0001034, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000370 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000387 ] . obo:OBI_0001073 obo:IAO_0000111 "microtome knife maker" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A glass cutting and breaking device that is used to produce glass knives used in ultramicrotomy." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "microtome knife maker" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0001074 obo:IAO_0000111 "cryofixation device" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used for the fixation or stabilization of biological materials as the first step in specimen preparation for electron microscopy." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Cryofixation" ; a owl:Class ; rdfs:label "cryofixation device" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0001036 ] . obo:OBI_0001075 obo:IAO_0000111 "hybridization oven" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that creates an appropriate environment for nucleic acid hybridization." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "hybridization oven" ; rdfs:subClassOf obo:OBI_0000136, obo:OBI_0002089, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000370 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0001076 obo:IAO_0000111 "incubator shaker" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An incubating device that provides shaking motion for biomedical applications (e.g., cell cultures)." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "incubator shaker" ; rdfs:subClassOf obo:OBI_0002089, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000370 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000401 ] . obo:OBI_0001077 obo:IAO_0000111 "small-animal image acquisition device" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to image small laboratory animals (e.g., rats and mice) in vivo." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "small-animal image acquisition device" ; rdfs:subClassOf obo:OBI_0000398, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000397 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001078 obo:IAO_0000111 "infrared image acquisition device" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An image acquisition device that is responsive to an infrared emissive target within a given field of view." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "United States Patent 4107530" ; a owl:Class ; rdfs:label "infrared image acquisition device" ; rdfs:subClassOf obo:OBI_0000398, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000397 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001079 obo:IAO_0000111 "confocal microscope" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A microscope that is used to increase micrograph contrast and/or reconstruct three-dimensional images by using a spatial pinhole to eliminate out-of-focus light in specimens that are thicker than the focal plane." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Confocal_microscopy" ; a owl:Class ; rdfs:label "confocal microscope" ; rdfs:subClassOf obo:OBI_0400169, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001080 obo:IAO_0000111 "patch clamp device" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device used in electrophysiology that allows the study of single or multiple ion channels in cells." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Patch_clamp" ; a owl:Class ; rdfs:label "patch clamp device" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001081 obo:IAO_0000111 "gel imaging system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to acquire images of laboratory gels." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "gel imaging system" ; rdfs:subClassOf obo:OBI_0000398, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000397 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001082 obo:IAO_0000111 "protein separation apparatus" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used for the separation of proteins." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "protein separation apparatus" ; rdfs:subClassOf obo:OBI_0000932, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000372 ] . obo:OBI_0001083 obo:IAO_0000111 "multichannel electronic pipette" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A multichannel pipette that can be programmed by the user to aspirate a volume of liquid reagent or sample and dispense the aspirated volume or a series of aliquots in successive dispensing operations." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://www.faqs.org/patents/app/20090196797" ; a owl:Class ; rdfs:label "multichannel electronic pipette" ; rdfs:subClassOf obo:OBI_0001118 . obo:OBI_0001084 obo:IAO_0000111 "vitrification apparatus" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to effect the transition of a substance into a glass." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Glass_transition" ; a owl:Class ; rdfs:label "vitrification apparatus" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0001085 obo:IAO_0000111 "radiography instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An image acquisition device that uses ionizing electromagnetic radiation such as X-rays to view objects." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Medical_radiography" ; a owl:Class ; rdfs:label "radiography instrument" ; rdfs:subClassOf obo:OBI_0000398, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000397 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001086 obo:IAO_0000111 "radiation measurement device" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that consists of a radiosensitive detector and a means of recording the effects of radiation on the detector." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "radiation measurement device" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000368 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001087 obo:IAO_0000111 "lyophilizer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to freeze dry material." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Freeze_drying" ; a owl:Class ; rdfs:label "lyophilizer" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000375 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0001088 obo:IAO_0000111 "tandem mass spectrometer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A mass spectrometer in which ions are subjected to two or more sequential stages of analysis (which may be separated spatially or temporally) according to the quotient mass/charge." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://goldbook.iupac.org/T06250.html" ; a owl:Class ; rdfs:label "tandem mass spectrometer" ; rdfs:subClassOf obo:OBI_0000049 . obo:OBI_0001089 obo:IAO_0000111 "microhardness tester" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A hardness testing device that is used in light-optical microscopes." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "United States Patent 4611487" ; a owl:Class ; rdfs:label "microhardness tester" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001090 obo:IAO_0000111 "multimode microplate reader" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A microplate reader that can detect multiple types of absorbance, luminescence or fluorescence." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "multimode microplate reader" ; rdfs:subClassOf obo:OBI_0001058 . obo:OBI_0001091 obo:IAO_0000111 "mechanical balance" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A balance that is used to compare the weights of two bodies, to determine the difference in mass (or weight)." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://www.britannica.com/EBchecked/topic/49765/balance" ; a owl:Class ; rdfs:label "mechanical balance" ; rdfs:subClassOf obo:OBI_0001135 . obo:OBI_0001092 obo:IAO_0000111 "computer cluster" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A group of linked computers, working together closely so that in many respects they form a single computer." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Cluster_(computing)" ; a owl:Class ; rdfs:label "computer cluster" ; rdfs:subClassOf obo:OBI_0400107 . obo:OBI_0001093 obo:IAO_0000111 "microtome knife sharpener" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to sharpen knives used in microtomy." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "microtome knife sharpener" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0001094 obo:IAO_0000111 "plate shaker" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that provides shaking motion for microplates." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "plate shaker" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0001095 obo:IAO_0000111 "coagulation analyzer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device for automatically analyzing blood coagulation in a clinical laboratory." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "United States Patent 5439646" ; a owl:Class ; rdfs:label "coagulation analyzer" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001096 obo:IAO_0000111 "laser capture microdissection microscope" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A microscope that uses low-energy laser beams and special transfer film to lift single cells from a tissue." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://www.answers.com/topic/laser-capture-microdissection-microscope-in-medicine" ; a owl:Class ; rdfs:label "laser capture microdissection microscope" ; rdfs:subClassOf obo:OBI_0400169, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001097 obo:IAO_0000111 "liquid extraction robot" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A liquid handling device that provides automatic liquid extraction." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "liquid extraction robot" ; rdfs:subClassOf obo:OBI_0400112, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0001098 obo:IAO_0000111 "ultrasound machine" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to visualize subcutaneous body structures including tendons, muscles, joints, vessels and internal organs." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Sonography" ; a owl:Class ; rdfs:label "ultrasound machine" ; rdfs:subClassOf obo:OBI_0000398, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000397 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001099 obo:IAO_0000111 "immunoblot scanner" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used for the imaging of immunoblots." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "immunoblot scanner" ; rdfs:subClassOf obo:OBI_0000398, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000397 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001100 obo:IAO_0000111 "microcentrifuge" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of centrifuge that is designed for small tubes (0.2 ml to 2.0 ml), has a compact design, and has a small footprint." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Laboratory_centrifuge" ; a owl:Class ; rdfs:label "microcentrifuge" ; rdfs:subClassOf obo:OBI_0400106 . obo:OBI_0001101 obo:IAO_0000111 "electronic repeater pipette" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A micropipette that can be programmed by the user to aspirate a volume of liquid reagent or sample and dispense a series of aliquots in successive dispensing operations." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://www.faqs.org/patents/app/20090196797" ; a owl:Class ; rdfs:label "electronic repeater pipette" ; rdfs:subClassOf obo:OBI_0001128 . obo:OBI_0001102 obo:IAO_0000111 "electron paramagnetic resonance spectrometer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An spectrophotometer that is used to investigate chemical species that have one or more unpaired electrons, such as organic and inorganic free radicals or inorganic complexes possessing a transition metal ion." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Electron_paramagnetic_resonance" ; a owl:Class ; rdfs:label "electron paramagnetic resonance spectrometer" ; rdfs:subClassOf obo:OBI_0400115 . obo:OBI_0001103 obo:IAO_0000111 "rocker" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that provides three-dimensional motion for biomedical applications (e.g., gel trays)." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "rocker" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0001104 obo:IAO_0000111 "analytical balance" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A balance with weighing pan(s) inside a transparent enclosure that is used to measure mass to a very high degree of precision and accuracy." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Weighing_scale" ; a owl:Class ; rdfs:label "analytical balance" ; rdfs:subClassOf obo:OBI_0001135 . obo:OBI_0001105 obo:IAO_0000111 "scanning force microscope" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A microscope that forms images of surfaces using a physical probe that scans the specimen." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Scanning_probe_microscopy" ; a owl:Class ; rdfs:label "scanning force microscope" ; rdfs:subClassOf obo:OBI_0400169, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001106 obo:IAO_0000111 "pulsed-field gel electrophoresis system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A gel electrophoresis system in which the gel matrix is subjected to an electric field that periodically changes direction." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Pulsed_field_gel_electrophoresis" ; a owl:Class ; rdfs:label "pulsed-field gel electrophoresis system" ; rdfs:subClassOf obo:OBI_0001121 . obo:OBI_0001107 obo:IAO_0000111 "tissue embedding station" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to perform paraffin embedding of tissue specimens." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "tissue embedding station" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0001108 obo:IAO_0000111 "nucleic acid sequencer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An device that is used to determine the order of nucleotides in nucleic acid sequences." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "nucleic acid sequencer" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001109 obo:IAO_0000111 "bead array reader" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to acquire and image bead array data." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "bead array reader" ; rdfs:subClassOf obo:OBI_0000398, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000397 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001110 obo:IAO_0000111 "real-time PCR machine" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An PCR instrument that enables both detection and quantification of one or more specific sequences in a DNA sample." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Real-time_polymerase_chain_reaction" ; a owl:Class ; rdfs:label "real-time PCR machine" ; rdfs:subClassOf obo:OBI_0000989 . obo:OBI_0001111 obo:IAO_0000111 "paraffin oven" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used for the warming of paraffin embedding medium." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "paraffin oven" ; rdfs:subClassOf obo:OBI_0000967, obo:OBI_0001034, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000370 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000371 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0001112 obo:IAO_0000111 "autoclave" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to sterilize equipment and supplies by subjecting them to high pressure steam at 121 C or more, typically for 15 to 20 minutes depending on the size of the load and the contents." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "J. Black, Microbiology, Prentice Hall (1993) pg. 334; http://en.wikipedia.org/wiki/Autoclave" ; a owl:Class ; rdfs:label "autoclave" ; rdfs:subClassOf obo:OBI_0001034, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000371 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000946 ] . obo:OBI_0001113 obo:IAO_0000111 "microplate washer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to wash immunoassays in microwell strips and plates with professional accuracy. WHAT IS PROFESSIONAL ACCURACY??" ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://www.articlesnatch.com/Article/Microplate-Readers-And-Washers-For-Laboratories/948037" ; a owl:Class ; rdfs:label "microplate washer" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0001114 obo:IAO_0000111 "nucleic acid extraction/purification instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to isolate and collect nucleic acids (DNA or RNA) for subsequent molecular analysis." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "nucleic acid extraction/purification instrument" ; rdfs:subClassOf obo:OBI_0000932, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000372 ] . obo:OBI_0001115 obo:IAO_0000111 "ELISA microplate washer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A microplate washer that is used for enzyme-linked immunosorbent assays (ELISA)." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "ELISA microplate washer" ; rdfs:subClassOf obo:OBI_0001113 . obo:OBI_0001116 obo:IAO_0000111 "vacuum manifold" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used for the vacuum-driven processing of multiwell strips or plates, or spin columns. IS THIS AN INSTRUMENT? IS THE DEFINTION CORRECT - TO DISTRIBUTE PRESSURE EVENLY." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "vacuum manifold" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0001117 obo:IAO_0000111 "DNA extraction/purification instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to isolate and collect DNA for subsequent molecular analysis." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/DNA_extraction" ; a owl:Class ; rdfs:label "DNA extraction/purification instrument" ; rdfs:subClassOf obo:OBI_0001114 . obo:OBI_0001118 obo:IAO_0000111 "multichannel pipette" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pipetting system that has a plurality of tip fittings and is used for multi-well plate applications." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "multichannel pipette" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001119 obo:IAO_0000111 "cell harvester" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to harvest cells from microplates and deposit samples on a filter mat. NOT AN INSTRUMENT?" ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "cell harvester" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0001043 ] . obo:OBI_0001120 obo:IAO_0000111 "portable fluorometer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A compact fluorometer that can be carried or moved with ease." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "portable fluorometer" ; rdfs:subClassOf obo:OBI_0400143 . obo:OBI_0001121 obo:IAO_0000111 "gel electrophoresis system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An electrophoresis system in which an electric field is applied to a gel matrix" ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Gel_electrophoresis" ; a owl:Class ; rdfs:label "gel electrophoresis system" ; rdfs:subClassOf obo:OBI_0001053 . obo:OBI_0001122 obo:IAO_0000111 "diffractometer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A measurement device for analyzing the structure of a material from the scattering pattern produced when a beam of radiation or particles (e.g. X rays or neutrons) interacts with it." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Diffractometer" ; a owl:Class ; rdfs:label "diffractometer" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001123 obo:IAO_0000111 "microdissection instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used for the dissection of tissues under magnification." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://medical-dictionary.thefreedictionary.com/microdissection" ; a owl:Class ; rdfs:label "microdissection instrument" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0001124 obo:IAO_0000111 "micropipette puller" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to fabricate glass micropipettes." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Micropipette" ; a owl:Class ; rdfs:label "micropipette puller" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0001125 obo:IAO_0000111 "laser scanning confocal microscope" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A confocal microscope that obtains high-resolution optical images with depth selectivity, in which a laser beam passes through a light source aperture and then is focused by an objective lens into a small (ideally diffraction limited) focal volume within or on the surface of a specimen." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Confocal_laser_scanning_microscopy" ; a owl:Class ; rdfs:label "laser scanning confocal microscope" ; rdfs:subClassOf obo:OBI_0001079, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001126 obo:IAO_0000111 "digital microscope" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A microscope that uses optics and a charge-coupled device (CCD) camera to output a digital image to a monitor." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Digital_microscope" ; a owl:Class ; rdfs:label "digital microscope" ; rdfs:subClassOf obo:OBI_0400169, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001127 obo:IAO_0000111 "freeze substitution system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device or system for dehydrating and then chemically fixing electron microscopy samples at low temperatures in preparation for various treatments including embedding in resins." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "doi:10.1017/S143192760707866X" ; a owl:Class ; rdfs:label "freeze substitution system" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000375 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0001128 obo:IAO_0000111 "micropipette" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A microinjection device that is used to measure very small volumes of liquids." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://www.answers.com/topic/micropipette" ; a owl:Class ; rdfs:label "micropipette" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001129 obo:IAO_0000111 "voltage clamp device" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to measure the ion currents across the membrane of excitable cells, such as neurons, while holding the membrane voltage at a set level." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Voltage_clamp" ; a owl:Class ; rdfs:label "voltage clamp device" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001130 obo:IAO_0000111 "vacuum oven" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that heats materials in a vacuum." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "vacuum oven" ; rdfs:subClassOf obo:OBI_0000967, obo:OBI_0001034, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000370 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000371 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0001131 obo:IAO_0000111 "slide warmer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to heat microscope slides." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "slide warmer" ; rdfs:subClassOf obo:OBI_0001034, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000371 ] . obo:OBI_0001132 obo:IAO_0000111 "capillary electrophoresis instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An electrophoresis system that is used to separate ionic species by their charge and frictional forces and mass." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Capillary_electrophoresis" ; a owl:Class ; rdfs:label "capillary electrophoresis instrument" ; rdfs:subClassOf obo:OBI_0001053 . obo:OBI_0001133 obo:IAO_0000111 "denaturing high-performance liquid chromatography instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A high performance liquid chromatography instrument that employs temperature-dependent separation of DNA containing mismatched base pairs from PCR-amplified DNA fragments for chromatographic mutation analysis." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "doi:10.1385/1-59259-850-1:173" ; a owl:Class ; rdfs:label "denaturing high-performance liquid chromatography instrument" ; rdfs:subClassOf obo:OBI_0000932, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000372 ] . obo:OBI_0001134 obo:IAO_0000111 "agarose gel electrophoresis system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A gel electrophoresis system that is used to separate DNA or RNA molecules by size, achieved by moving negatively charged nucleic acid molecules through an agarose matrix with an electric field." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Agarose_gel_electrophoresis" ; a owl:Class ; rdfs:label "agarose gel electrophoresis system" ; rdfs:subClassOf obo:OBI_0001121 . obo:OBI_0001135 obo:IAO_0000111 "balance" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A measuring instrument that is used to determine the weight or mass of an object." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Weighing_scale" ; a owl:Class ; rdfs:label "balance" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001136 obo:IAO_0000111 "surface plasmon resonance instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A tool for measuring adsorption of material onto planar metal (typically gold and silver) surfaces or onto the surface of metal nanoparticles." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Surface_plasmon_resonance" ; a owl:Class ; rdfs:label "surface plasmon resonance instrument" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001137 obo:IAO_0000111 "protein sequencer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An device that is used to determine the order of amino acids in protein sequences." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000119 "PERSON: Erik Segerdell" ; a owl:Class ; rdfs:label "protein sequencer" ; rdfs:subClassOf obo:OBI_0000832, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000453 ] . obo:OBI_0001138 obo:IAO_0000111 "X-ray source" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is used to generate X-rays." ; obo:IAO_0000117 "PERSON: Erik Segerdell" ; obo:IAO_0000118 "x-ray generator" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/X-ray_generator" ; a owl:Class ; rdfs:label "X-ray source" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000374 ] . obo:OBI_0001139 obo:IAO_0000111 "liquid chromatography instrument" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A chromatography device that dissolves a mixture in liquid mobile phase to separate the analyte to be measured from other molecules in the mixture and allows it to be isolated" ; obo:IAO_0000117 "PERSON: Matthew Brush" ; obo:IAO_0000119 "PERSON: Matthew Brush" ; a owl:Class ; rdfs:label "liquid chromatography instrument" ; rdfs:subClassOf obo:OBI_0000048 . obo:OBI_0001140 obo:IAO_0000111 "spike-in quality control role"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a reference substance role that is borne by a material entity with a known amount which is mixed into the evaluant of assays for quality control or data normalization purposes"@en ; obo:IAO_0000117 "PERSON: Chris Stoeckert, Jie Zheng, Bjoern Peter"@en ; obo:IAO_0000119 "MO_937 spike_quality_control"@en ; a owl:Class ; rdfs:label "spike-in quality control role"@en ; rdfs:subClassOf obo:OBI_0000025 . obo:OBI_0001141 obo:IAO_0000111 "individual organism identifier"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a CRID symbol used to distinguish one individual organism from another."@en ; obo:IAO_0000117 "PERSON: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_169 Individual"@en ; a owl:Class ; rdfs:label "individual organism identifier"@en ; rdfs:subClassOf obo:IAO_0000577, [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0100026 ; owl:onProperty obo:IAO_0000219 ] . obo:OBI_0001142 obo:IAO_0000111 "dye swap quality control role"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a reference substance role that is borne by a material entity used in a dye swap design experiment for quality control or data normalization purposes"@en ; obo:IAO_0000117 "PERSON: Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "MO_524 dye_swap_quality_control"@en ; a owl:Class ; rdfs:label "dye swap quality control role"@en ; rdfs:subClassOf obo:OBI_0000025, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001143 ] . obo:OBI_0001143 obo:IAO_0000111 "labeled nucleic acid extract" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a labeled specimen that is the output of a labeling process and has grain labeled nucleic acid for detection of the nucleic acid in future experiments." ; obo:IAO_0000117 "Person: Jie Zheng" ; obo:IAO_0000118 "labeled extract" ; obo:IAO_0000119 "MO_221 labeledExtract" ; obo:OBI_0001847 "labeled extract" ; a owl:Class ; rdfs:label "labeled nucleic acid extract" ; rdfs:subClassOf obo:OBI_0000924, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0600038 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001010 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:CHEBI_33696 ] . obo:OBI_0001144 obo:IAO_0000111 "binding constant"@en ; obo:IAO_0000112 "The predicted or measured binding affinity of a peptide to a MHC molecule can be captured in the binding constants \"IC50 = 12 nM\" or \"t 1/2 = 30 minutes\"."@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A quantitative binding datum that is expressed as a scalar number and a unit, which can be utilized in equations that model the binding process independent of the specific assay performed."@en ; obo:IAO_0000116 "10/6/11 BP: The distinction between binding datum and binding constant is based on the later being part of an equation. That should be captured in the logical definition here, and used to make it to a defined class." ; obo:IAO_0000117 "PERSON: Bjoern Peters, Randi Vita, Jason Greenbaum"@en ; a owl:Class ; rdfs:label "binding constant"@en ; rdfs:subClassOf obo:OBI_0003142 . obo:OBI_0001145 obo:IAO_0000111 "3D structure determination of bound molecular complex assay" ; obo:IAO_0000112 "Determination of a 3D structure of an antibody binding a protein by X-Ray crystallography, which identifies the specific binding site of the antibody." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A 3D molecular structure determination assay in which a complex of 2 or more molecular enties is characterized which provides information on their binding configuration." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "3D structure determination of bound molecular complex assay" ; rdfs:subClassOf obo:OBI_0003117 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003117 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001155 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:COB_0000080 ] ] ) ] . obo:OBI_0001146 obo:IAO_0000111 "binding assay" ; obo:IAO_0000112 "Determination of KD value for an antibody binding a protein using a BIACORE assay. Using plate bound antigen in an ELISA to determine if a mixture of serum antibodies bind the antigen. The following are NOT binding assays, as the desired output is not binding data: RNA microarray experiments to determine levels of gene expression. ChIP experiments to determine where in DNA a transcription factor binds. Using an IL-2 antibody on an ELISA plate to determine presence of IL-2 after stimulating a T cell culture." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay with the objective to characterize the disposition of two or more material entities to form a complex." ; obo:IAO_0000117 "Bjoern Peters", "Jason Greenbaum", "Randi Vita" ; a owl:Class ; rdfs:label "binding assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001181 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001588 ] ] . obo:OBI_0001147 obo:IAO_0000111 "cell culture expansion"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a process that results in the increase of cell numbers"@en ; obo:IAO_0000116 "including grow of yeast and bacteria"@en ; obo:IAO_0000117 "PERSON: Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "MO_758 grow"@en ; obo:IAO_0000232 """BP: add it as subclass of 'cell culturing' JZ: No 'cell culturing' in OBI Has term 'cell co-culturing' and 'maintaining cell culture'. Don't think either of it fit. So leave the term under process."""@en ; a owl:Class ; rdfs:label "cell culture expansion"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100060 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0100060 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0001148 obo:IAO_0000111 "gene knock out"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a genetic transformation that renders a gene non-functional, e.g. due to a point mutation, or the removal of all, or part of, the gene using recombinant methods."@en ; obo:IAO_0000117 "PERSON: Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "MO_771 gene_knock_out"@en ; a owl:Class ; rdfs:label "gene knock out"@en ; rdfs:subClassOf obo:OBI_0600043 . obo:OBI_0001149 obo:IAO_0000111 "gene knock in"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a genetic transformation that involves the insertion of a protein coding cDNA sequence at a particular locus in an organism's chromosome. Typically, this is done in mice since the technology for this process is more refined, and because mouse embryonic stem cells are easily manipulated. The difference between knock-in technology and transgenic technology is that a knock-in involves a gene inserted into a specific locus, and is a \"targeted\" insertion."@en ; obo:IAO_0000117 "PERSON: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_437 gene_knock_in"@en, "WEB: http://en.wikipedia.org/wiki/Gene_Knock-in"@en ; a owl:Class ; rdfs:label "gene knock in"@en ; rdfs:subClassOf obo:OBI_0600043 . obo:OBI_0001150 obo:IAO_0000111 "chromosomal substitution"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A genetic transformation in which all, or part, of a chromosome from a donor replaces that of the recipient. It does not include chromosome recombination. For single gene insertion, use the term 'gene knock in'."@en ; obo:IAO_0000117 "PERSON: Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "MO_995 chromosomal_substitution"@en ; a owl:Class ; rdfs:label "chromosomal substitution"@en ; rdfs:subClassOf obo:OBI_0600043 . obo:OBI_0001151 obo:IAO_0000111 "genetically modified material"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a material entity, organism or cell, that is the output of a genetic transformation process."@en ; obo:IAO_0000117 "PERSON: Jie Zheng"@en ; obo:IAO_0000119 "GROUP: OBI"@en ; obo:IAO_0000232 "term is proposed by BP on Oct 25, 2010 dev call"@en ; a owl:Class ; rdfs:label "genetically modified material"@en ; rdfs:subClassOf obo:OBI_0000047 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:OBI_0302859 [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600043 ] ) ] ) ] . obo:OBI_0001152 obo:IAO_0000111 "transfection" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a genetic transformation which relies on the use of physical, electrical and chemical phenomena to introduce DNA or RNA into a cell"@en ; obo:IAO_0000117 "PERSON: Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "MO_366 transfection" ; a owl:Class ; rdfs:label "transfection"@en ; rdfs:subClassOf obo:OBI_0600043, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0600033 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:unionOf (obo:CHEBI_16991 obo:CHEBI_33697 ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:OBI_0000444 ] ) ] ] . obo:OBI_0001153 obo:IAO_0000111 "genetic transformation objective"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a material transformation objective aims to create genetically modified organism or cell"@en ; obo:IAO_0000117 "Person: Jie Zheng"@en ; obo:IAO_0000119 "Person: Jie Zheng"@en ; obo:IAO_0000232 "suggested to be added by BP and AR during Oct 25, 2010 dev call" ; a owl:Class ; rdfs:label "genetic transformation objective"@en ; rdfs:subClassOf obo:OBI_0000456 . obo:OBI_0001154 obo:IAO_0000111 "induced mutagenesis"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A genetic transformation that is the modification of the genetic material (either coding or non-coding) of an organism caused by mutagenic processes, compounds, or irradiation."@en ; obo:IAO_0000116 "Label and definition were clarified as per https://github.com/obi-ontology/obi/issues/1366" ; obo:IAO_0000117 "PERSON: Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "MO_564 induced_mutation"@en ; a owl:Class ; rdfs:label "induced mutagenesis"@en ; rdfs:subClassOf obo:OBI_0600043 . obo:OBI_0001155 obo:IAO_0000111 "3D structural organization datum" ; obo:IAO_0000112 "The atom coordinates found in a PDB (Protein Data Bank) file, generated by X Ray crystallography or NMR." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A measurement datum that describes the structural orientation of a material entity in 3D space." ; obo:IAO_0000117 "PERSON: Jason Greenbaum, Randi Vita, Bjoern Peters" ; a owl:Class ; rdfs:label "3D structural organization datum" ; rdfs:subClassOf obo:IAO_0000109 . obo:OBI_0001156 obo:IAO_0000111 "age since planting measurement datum"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An age measurement datum that is the result of the measurement of the age of an organism since planting, the process of placing a plant in media (e.g. soil) to allow it to grow, which excludes sowing." ; obo:IAO_0000117 "PERSON:Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_495 planting" ; obo:IAO_0000232 """Discussed by Jie and Chris, proposed to combine with different kinds of processes as initial time point. Proposed 'age measurement assay' is proceeded by some process. The process can be any kind of process defined in OBI. Think it is more flexible. However, it is hard to model due to lake of temporal predicates on Nov 15, 2010 dev call. Term proposed by Bjoern on Nov 8, 2010 dev call Supported by Alan on Nov 15, 2010 dev call""" ; a owl:Class ; rdfs:label "age since planting measurement datum"@en ; rdfs:subClassOf obo:OBI_0001167 . obo:OBI_0001157 obo:IAO_0000111 "age since hatching measurement datum"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An age measurement datum that is the result of the measurement of the age of an organism since hatching, the process of emergence from an egg." ; obo:IAO_0000117 "PERSON:Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_745 hatching" ; a owl:Class ; rdfs:label "age since hatching measurement datum"@en ; rdfs:subClassOf obo:OBI_0001167 . obo:OBI_0001158 obo:IAO_0000111 "age determination assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that determines the duration of part of the life of an organism, where the initial time point is the beginning of some transitional state (such as birth or when planted)." ; obo:IAO_0000116 "This assay measures time not developmental stage. we recognize that development takes different time periods under different conditions such as media / temperature. For example, age measurement assay of fly age, the output likes 28 days but not mid-life of age at room temperature." ; obo:IAO_0000117 "Alan Ruttenberg" ; obo:IAO_0000118 "age measurement assay" ; obo:IAO_0000119 "OBI group" ; a owl:Class ; rdfs:label "age determination assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0100026 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001167 ] . obo:OBI_0001159 obo:IAO_0000111 "age since egg laying measurement datum"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An age measurement datum that is the result of the measurement of the age of an organism since egg laying, the process of the production of egg(s) by an organism." ; obo:IAO_0000117 "PERSON:Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_767 egg laying" ; a owl:Class ; rdfs:label "age since egg laying measurement datum"@en ; rdfs:subClassOf obo:OBI_0001167 . obo:OBI_0001160 obo:IAO_0000111 "assay validation objective"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "an objective specification to check the accuracy or the quality of the results of an assay by comparison with independent results"@en ; obo:IAO_0000117 "PERSON: Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "GROUP: Penn Group"@en ; a owl:Class ; rdfs:label "assay validation objective"@en ; rdfs:subClassOf obo:IAO_0000005 . obo:OBI_0001161 obo:IAO_0000111 "age since germination measurement datum"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An age measurement datum that is the result of the measurement of the age of an organism since germination, the process consisting of physiological and developmental changes by a seed, spore, pollen grain (microspore), or zygote that occur after release from dormancy, and encompassing events prior to and including the first visible indications of growth." ; obo:IAO_0000116 "Definition of germination comes from GO. However, the term is deprecated from GO now because it is a grouping term without biological significance." ; obo:IAO_0000117 "PERSON:Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_590 germination" ; a owl:Class ; rdfs:label "age since germination measurement datum"@en ; rdfs:subClassOf obo:OBI_0001167 . obo:OBI_0001162 obo:IAO_0000111 "validation by reverse transcription PCR design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a study design in which checks the accuracy or the quality of the result of an assay by comparing with reverse transcription PCR results" ; obo:IAO_0000117 "PERSON: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_986 reverse_transcription_PCR_quality_control" ; a owl:Class ; rdfs:label "validation by reverse transcription PCR design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0001163 obo:IAO_0000111 "age since eclosion measurement datum"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An age measurement datum that is the result of the measurement of the age of an organism since eclosion, the process of emergence of an adult insect from its pupa or cocoon." ; obo:IAO_0000117 "PERSON:Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_876 eclosion" ; a owl:Class ; rdfs:label "age since eclosion measurement datum"@en ; rdfs:subClassOf obo:OBI_0001167 . obo:OBI_0001164 obo:IAO_0000111 "age since sowing measurement datum"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An age measurement datum that is the result of the measurement of the age of an organism since sowing, the process of placing a seed or spore in some media with the intention to invoke germination." ; obo:IAO_0000117 "PERSON:Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_748 sowing" ; a owl:Class ; rdfs:label "age since sowing measurement datum"@en ; rdfs:subClassOf obo:OBI_0001167 . obo:OBI_0001165 obo:IAO_0000111 "age since coitus measurement datum"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An age measurement datum that is the result of the measurement of the age of an organism since coitus, the process of copulation that occurs during the process of sexual reproduction." ; obo:IAO_0000117 "PERSON:Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_783 coitus" ; a owl:Class ; rdfs:label "age since coitus measurement datum"@en ; rdfs:subClassOf obo:OBI_0001167 . obo:OBI_0001166 obo:IAO_0000111 "validation by real time PCR design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a study design in which the accuracy or the quality of the result of an assay is checked by comparing with real time PCR results" ; obo:IAO_0000117 "PERSON: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_434 real_time_PCR_quality_control" ; a owl:Class ; rdfs:label "validation by real time PCR design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0001167 obo:IAO_0000111 "age measurement datum"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A time measurement datum that is the result of measurement of age of an organism" ; obo:IAO_0000116 """note that we are currently defining subtypes of age measurement datum that specify when the age is relative to, e.g. planting, as we don't have adequate temporal predicates yet. life of bearer doesn't imply organism this assay measures time not developmental stage. we recognize that development can take different time periods under different conditions such as media / temperature age as a quality is dubious; we plan to revisit stages in development are currently handled with controlled vocabulary, such as 2-somite stage.""" ; obo:IAO_0000117 "PERSON: Alan Ruttenberg, Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_178 Age" ; obo:IAO_0000232 """In MageTab file, we use initialTimePoint (a process) + age (a number expected) + TimeUnit (definied in UO, such as year, hour, day, etc.) Now we use the term label indicating the start time point of measuring the age, (number + TimeUnit) are expected instances of the class""", """discussed on Nov 15, dev call All subtype will be defined by textual definition now.""" ; a owl:Class ; rdfs:label "age measurement datum"@en ; rdfs:subClassOf obo:IAO_0000416, [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:PATO_0000011 ] . obo:OBI_0001168 obo:IAO_0000111 "age since fertilization measurement datum"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An age measurement datum that is the result of the measurement of the age of an organism since fertilization, the process of the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote." ; obo:IAO_0000116 "Definition of fertilization comes from GO." ; obo:IAO_0000117 "PERSON:Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_701 fertilization" ; a owl:Class ; rdfs:label "age since fertilization measurement datum"@en ; rdfs:subClassOf obo:OBI_0001167 . obo:OBI_0001169 obo:IAO_0000111 "age since birth measurement datum"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An age measurement datum that is the result of the measurement of the age of an organism since birth, the process of emergence and separation of offspring from the mother." ; obo:IAO_0000117 "PERSON:Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_710 birth" ; a owl:Class ; rdfs:label "age since birth measurement datum"@en ; rdfs:subClassOf obo:OBI_0001167 . obo:OBI_0001170 obo:IAO_0000111 "reverse transcription polymerase chain reaction assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that determines the concentration of RNA in a sample in which an RNA strand is first reverse transcribed into its DNA complement (complementary DNA, or cDNA) using the enzyme reverse transcriptase, and the resulting cDNA is amplified using traditional or real-time PCR." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng" ; obo:IAO_0000119 "Penn Group" ; a owl:Class ; rdfs:label "reverse transcription polymerase chain reaction assay" ; rdfs:subClassOf obo:OBI_0002692, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000880 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000880 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000552 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000880 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000030 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0010467 ] ] . obo:OBI_0001171 obo:IAO_0000111 "half life datum (t 1/2)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The time it takes for 50% of a class of stochastic processes to occur." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000118 "t 1/2" ; obo:IAO_0000119 "Bjoern Peters" ; a owl:Class ; rdfs:label "half life datum (t 1/2)" ; rdfs:subClassOf obo:IAO_0000416, [ a owl:Restriction ; owl:onProperty obo:IAO_0000039 ; owl:someValuesFrom obo:UO_0000003 ] . obo:OBI_0001172 obo:IAO_0000111 "dose response curve" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item of paired values, one indicating the dose of a material, the other quantitating a measured effect at that dose. The dosing intervals are chosen so that effect values be interpolated by a plotting a curve." ; obo:IAO_0000117 "Bjoern Peters; Randi Vita" ; a owl:Class ; rdfs:label "dose response curve" ; rdfs:subClassOf obo:IAO_0000573 . obo:OBI_0001173 obo:IAO_0000111 "service" ; obo:IAO_0000112 "providing a training course for UCSD employees how to run a DNA sequencer; sequencing a DNA sample provided by a service consumer restricted to non-human samples; giving access to tissue samples in a biobank within OHSU; JAX shipping mice from their colony." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process in which a service provider performs a task (i.e. a planned process) for a service consumer." ; obo:IAO_0000117 "Carlo; Matt" ; obo:IAO_0000119 "OBI workshop San Diego 2011" ; a owl:Class ; rdfs:label "service" ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000011 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000011 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_0000941 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_0000947 ] ) ] ) ] . obo:OBI_0001174 obo:IAO_0000111 "passive immunization" ; obo:IAO_0000112 "Giving VIG (concentrated antibodies from vaccinated donors) to a patient that is infected with smallpox. Transferring epitope specific T cells from one mouse into another." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The injection of immune effector material (antibodies, T cells or B cells) into an organism so that the organisms immune system gains its immune effector function to recognize specific antigens." ; obo:IAO_0000117 "PERSON: Bjoern Peters, Randi Vita, Jason Greenbaum" ; obo:IAO_0000118 "adoptive transfer" ; a owl:Class ; rdfs:label "passive immunization" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000319 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_1110022 ] ) ] ] . obo:OBI_0001175 obo:IAO_0000111 "selective organism creation objective"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "an objective specification to generate a population or type of organism within species that have some uniform behavioral, morphological, physiological, or genetic characteristics with similarly bred organisms." ; obo:IAO_0000117 "PERSON: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 """WEB: wikipedia http://en.wikipedia.org/wiki/Cultivar http://en.wikipedia.org/wiki/Ecotype http://en.wikipedia.org/wiki/Strain_%28biology%29""" ; a owl:Class ; rdfs:label "selective organism creation objective"@en ; rdfs:subClassOf obo:IAO_0000005 . obo:OBI_0001176 obo:IAO_0000111 "Individual epitope immunization in vivo" ; obo:IAO_0000112 "Injection of a peptide T cell epitope into a mouse" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An immunization in which an individual epitope is administered into a host organism." ; obo:IAO_0000116 "3/16/11 BP: This should have as a logical definition the exclusion that the immunogen cannot be something beyond the epitope itself. I don't know if that is possible to do here." ; obo:IAO_0000117 "PERSON:Bjoern Peters, Jason Greenbaum, Randi Vita" ; a owl:Class ; rdfs:label "Individual epitope immunization in vivo" ; rdfs:subClassOf obo:OBI_1110015 . obo:OBI_0001177 obo:IAO_0000111 "RNA sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that determines the sequence of an RNA molecule." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "Bjoern Peters" ; a owl:Class ; rdfs:label "RNA sequencing assay" ; rdfs:subClassOf obo:OBI_0600047 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600047 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400103 ] ) ] [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000880 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000880 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0600028 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000880 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000973 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000845 ] ] ) ] . obo:OBI_0001178 obo:IAO_0000111 "efficacy of epitope intervention experiment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that tests if inducing an epitope specific immune response in an organism has an effect, such as the ability to prevent, treat or exacerbate diseases in the organism." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000118 "efficacy of in vivo intervention" ; a owl:Class ; rdfs:label "efficacy of epitope intervention experiment" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0001179 obo:IAO_0000111 "epitope protection from infectious challenge experiment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An epitope protection experiment in which the ability of the epitope to protect the host from an infection is assessed." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000118 "protection from infectious challenge" ; a owl:Class ; rdfs:label "epitope protection from infectious challenge experiment" ; rdfs:subClassOf obo:OBI_0001184 . obo:OBI_0001180 obo:IAO_0000111 "half maximal effective concentration (EC50)" ; obo:IAO_0000112 "Determining the potentency of a drug / antibody / toxicant by measuring a graded dose response curve, and determining the concentration of the compound where 50% of its maximal effect is observed." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "half maximal effective concentration (EC50) is a scalar measurement datum corresponding to the concentration of a compound which induces a response halfway between the baseline and maximum after some specified exposure time." ; obo:IAO_0000117 "Bjoern Peters; Randi Vita" ; obo:IAO_0000119 "wikipedia" ; a owl:Class ; rdfs:label "half maximal effective concentration (EC50)" ; rdfs:subClassOf obo:IAO_0000032, [ a owl:Restriction ; owl:onProperty obo:IAO_0000039 ; owl:someValuesFrom obo:UO_0000051 ], [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001172 ] . obo:OBI_0001181 obo:IAO_0000111 "binding datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item that states if two or more material entities have the disposition to form a complex, and if so, how strong that disposition is." ; obo:IAO_0000117 "Bjoern Peters; Randi Vita" ; a owl:Class ; rdfs:label "binding datum" ; rdfs:subClassOf obo:IAO_0000027 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:IAO_0000027 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001588 ] ) ] . obo:OBI_0001182 obo:IAO_0000111 "negative binding datum" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A categorical binding datum that states that there is no significant disposition of two or more entities to form a complex." ; a owl:Class ; rdfs:label "negative binding datum" ; rdfs:subClassOf obo:OBI_0003141 . obo:OBI_0001183 obo:IAO_0000111 "epitope protection from tumor challenge experiment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An epitope protection experiment in which the ability of the epitope to protect the host from developing tumors is assessed." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000118 "protection from tumor challenge" ; a owl:Class ; rdfs:label "epitope protection from tumor challenge experiment" ; rdfs:subClassOf obo:OBI_0001184 . obo:OBI_0001184 obo:IAO_0000111 "epitope protection experiment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An efficacy of epitope intervention experiment that tests the efficacy of inducing an immune epitope response to prevent disease in a host." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000118 "protection from challenge" ; a owl:Class ; rdfs:label "epitope protection experiment" ; rdfs:subClassOf obo:OBI_0001178 . obo:OBI_0001185 obo:IAO_0000111 "selectively maintained organism"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism that is bred to have some uniform behavioral, morphological, physiological, or genetic characteristics with similarly bred organisms" ; obo:IAO_0000117 "Bjoern Peters, Helen Parkinson, Philippe Rocca-Serra, Jie Zheng, Chris Stoeckert" ; obo:IAO_0000118 "cultivar", "ecotype", "strain" ; obo:IAO_0000119 "MO_9 StrainOrLine, MO_71 Ecotype, MO_124 Cultivar" ; a owl:Class ; rdfs:label "selectively maintained organism"@en ; rdfs:subClassOf obo:OBI_0100026 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000011 [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001175 ] ) ] ] ) ] . obo:OBI_0001186 obo:IAO_0000111 "epitope protection from infectious challenge experiment based on pathogen burden" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An epitope protection from infectious challenge experiment in which the readout is a reduction in the presence of pathogens in the host compared to controls." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000118 "burden after infectious challenge" ; a owl:Class ; rdfs:label "epitope protection from infectious challenge experiment based on pathogen burden" ; rdfs:subClassOf obo:OBI_0001179 . obo:OBI_0001187 obo:IAO_0000111 "infectious agent detection assay" ; obo:IAO_0000112 "Culturing a sputum sample on agar medium to detect bacterial growth; Stain slices of liver from a mouse to count presence of infectious centers; PCR amplification using primers specific for influenza virus." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures the presence or amount of an infectious agent in an evaluant" ; obo:IAO_0000117 "Bjoern Peters", "Jason Greenbaum", "Randi Vita", "Richard Scheuermann" ; a owl:Class ; rdfs:label "infectious agent detection assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:IDO_0000586 ] ] . obo:OBI_0001188 obo:IAO_0000111 "epitope disease exacerbation experiment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An efficacy of epitope intervention experiment that tests the ability of inducing an epitope immune response to increase the severity of an existing disease in the host." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000118 "exacerbation assay" ; a owl:Class ; rdfs:label "epitope disease exacerbation experiment" ; rdfs:subClassOf obo:OBI_0001178 . obo:OBI_0001189 obo:IAO_0000111 "epitope protection experiment based on survival" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An epitope protection experiment that determines the success of the epitope intervention based on increased survival of the host." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000118 "host survival after challenge" ; a owl:Class ; rdfs:label "epitope protection experiment based on survival" ; rdfs:subClassOf obo:OBI_0001184 . obo:OBI_0001190 obo:IAO_0000111 "epitope treatment experiment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An epitope intervention experiment that tests the ability of inducing an epitope immune response to treat an existing disease in the host." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000118 "decreased disease symptoms after treatment" ; a owl:Class ; rdfs:label "epitope treatment experiment" ; rdfs:subClassOf obo:OBI_0001178 . obo:OBI_0001191 obo:IAO_0000111 "half maximal inhibitory concentration (IC50)" ; obo:IAO_0000112 "Interpolating that at a dose of IC50=12 nM, half of the binding of a comptetitive ligand is inhibited." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Half maximal inhibitory concentration (IC50) is a scalar measurement datum that measures the effectiveness of a compound to competitively inhibit a given process, and corresponds to the concentration of the compound at which it reaches half of its maximum inhibitory effect." ; obo:IAO_0000117 "Bjoern Peters; Randi Vita" ; obo:IAO_0000119 "wikipedia" ; a owl:Class ; rdfs:label "half maximal inhibitory concentration (IC50)" ; rdfs:subClassOf obo:IAO_0000032, [ a owl:Restriction ; owl:onProperty obo:IAO_0000039 ; owl:someValuesFrom obo:UO_0000051 ], [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001172 ] . obo:OBI_0001192 obo:IAO_0000111 "epitope specific immune intervention" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An administration in vivo to either actively or passively immunize an organism in order to induce a response against a specific immune epitope" ; obo:IAO_0000117 "Person: Bjoern Peters, Randi Vita, Jason Greenbaum" ; a owl:Class ; rdfs:label "epitope specific immune intervention" ; rdfs:subClassOf obo:OBI_0001174, [ a owl:Class ; owl:unionOf (obo:OBI_0001174 obo:OBI_0001176 ) ] . obo:OBI_0001193 obo:IAO_0000111 "epitope specific cytokine production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of cytokine production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific cytokine production by T cells" ; rdfs:subClassOf obo:GO_0001816 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0001816 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001194 obo:IAO_0000111 "ELISPOT assay measuring epitope specific transforming growth factor-beta production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunospot assay that detects transforming growth factor-beta production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TGFb release|ELISPOT" ; a owl:Class ; rdfs:label "ELISPOT assay measuring epitope specific transforming growth factor-beta production by T cells" ; rdfs:subClassOf obo:OBI_0001264, obo:OBI_0600031 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600031 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071604 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001195 obo:IAO_0000111 "operator variation design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that assesses the operator performance and relation to data consistency and quality." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_519 operator_variation_design" ; a owl:Class ; rdfs:label "operator variation design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_9606 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000116 ] ) ] ] ) ] ] . obo:OBI_0001196 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific IP-10 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects IP-10 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CXCL10/IP-10 release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific IP-10 production by T cells" ; rdfs:subClassOf obo:OBI_0001308, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071612 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001197 obo:IAO_0000111 "comparative genome hybridization by array design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that detects genomic copy number variations using microarray technology." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_856 comparative_genome_hybridization_design" ; a owl:Class ; rdfs:label "comparative genome hybridization by array design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000131 ] . obo:OBI_0001198 obo:IAO_0000111 "assay measuring epitope specific interleukin-27 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interleukin-27 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-27 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interleukin-27 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032631 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001199 obo:IAO_0000111 "in vivo design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that is conducted entirely in a living organism, e.g. a compound treatment in a mouse model." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_454 in_vivo_design" ; a owl:Class ; rdfs:label "in vivo design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0001200 obo:IAO_0000111 "genotyping by high throughput sequencing design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that classifies an individual or group of individuals on the basis of alleles, haplotypes, SNPs using high througput sequencing techniques." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_560 genotyping_design" ; a owl:Class ; rdfs:label "genotyping by high throughput sequencing design" ; rdfs:subClassOf obo:OBI_0001444 . obo:OBI_0001201 obo:IAO_0000111 "epitope specific tolerance induction by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of tolerance induction by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific tolerance induction by T cells" ; rdfs:subClassOf obo:GO_0002507 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0002507 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001202 obo:IAO_0000111 "innate behavior design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which the innate behavior of the organism is examined, e.g. path finding in bees." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_355 innate_behavior_design" ; a owl:Class ; rdfs:label "innate behavior design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000268 ] . obo:OBI_0001203 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific transforming growth factor-beta production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects transforming growth factor-beta production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TGFb release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific transforming growth factor-beta production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001264 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071604 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001204 obo:IAO_0000111 "SNP microarray" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA microarray used to detect polymorphisms in DNA samples" ; obo:IAO_0000117 "Person: Helen Parkinson" ; obo:IAO_0000119 "EFO_0002703 SNP array" ; a owl:Class ; rdfs:label "SNP microarray" ; rdfs:subClassOf obo:OBI_0400148 . obo:OBI_0001205 obo:IAO_0000111 "cell component comparison design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that compares samples from different cell components." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_1019 cell_component_comparison_design" ; a owl:Class ; rdfs:label "cell component comparison design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000219 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0005575 ] ) ] ] . obo:OBI_0001206 obo:IAO_0000111 "ELISPOT assay measuring epitope specific granulocyte macrophage colony-stimulating factor production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunospot assay that detects granulocyte macrophage colony stimulating factor production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "GM-CSF release|ELISPOT" ; a owl:Class ; rdfs:label "ELISPOT assay measuring epitope specific granulocyte macrophage colony-stimulating factor production by T cells" ; rdfs:subClassOf obo:OBI_0001233, obo:OBI_0600031 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600031 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032604 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001207 obo:IAO_0000111 "epitope specific macrophage inflammatory protein-1 alpha production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of macrophage inflammatory protein-1 alpha production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific macrophage inflammatory protein-1 alpha production by T cells" ; rdfs:subClassOf obo:GO_0071608, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0071608 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001208 obo:IAO_0000111 "epitope specific T cell activation" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of T cell activation resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific T cell activation" ; rdfs:subClassOf obo:GO_0042110 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0042110 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001209 obo:IAO_0000111 "assay measuring epitope specific interleukin-10 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interleukin-10 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-10 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interleukin-10 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032613 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001210 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific transforming growth factor-beta production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects transforming growth factor-beta production by T cells" ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TGFb release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific transforming growth factor-beta production by T cells" ; rdfs:subClassOf obo:OBI_0001264, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071604 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001211 obo:IAO_0000111 "ex vivo design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design where all or part of an organism is removed and studied in vitro, e.g. part of a mouse is removed and cultured in vitro. A cell culture with an established cell line is an in vitro experiment." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_808 ex_vivo_design" ; a owl:Class ; rdfs:label "ex vivo design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0001212 obo:IAO_0000111 "epitope specific type IV hypersensitivity by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of type IV hypersensitivity by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific type IV hypersensitivity by T cells" ; rdfs:subClassOf obo:GO_0001806 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0001806 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001213 obo:IAO_0000111 "eBioscience" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Karin Breuer" ; obo:IAO_0000119 "WEB:http://www.ebioscience.com/@2011/04/11" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "eBioscience" . obo:OBI_0001214 obo:IAO_0000111 "normalization testing design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that tests different normalization procedures." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_729 normalization_testing_design" ; a owl:Class ; rdfs:label "normalization testing design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000242 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0200169 ] ) ] ] . obo:OBI_0001215 obo:IAO_0000111 "intracellular material detection assay measuring epitope specific perforin release" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects epitope specific perforin release by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "perforin release|intracellular staining" ; a owl:Class ; rdfs:label "intracellular material detection assay measuring epitope specific perforin release" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0001497 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0003317 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001216 obo:IAO_0000111 "cell culture analyte detection bioassay measuring epitope specific interleukin-2 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A reporter cell line analyte detection bioassay that detects interleukin-2 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-2 release|bioassay" ; a owl:Class ; rdfs:label "cell culture analyte detection bioassay measuring epitope specific interleukin-2 production by T cells" ; rdfs:subClassOf obo:OBI_0000904, obo:OBI_0001445 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000904 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032623 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001217 obo:IAO_0000111 "assay measuring epitope specific interleukin-22 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interleukin-22 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-22 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interleukin-22 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032626 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001218 obo:IAO_0000111 "assay measuring epitope specific interleukin-8 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interleukin-8 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-8 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interleukin-8 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032637 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001219 obo:IAO_0000111 "epitope specific chemokine (C-C motif) ligand 1 production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of chemokine (C-C motif) ligand 1 production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific chemokine (C-C motif) ligand 1 production by T cells" ; rdfs:subClassOf obo:GO_0071610, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0071610 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001220 obo:IAO_0000111 "cell culture analyte detection bioassay measuring epitope specific interleukin-10 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A reporter cell line analyte detection bioassay that detects interleukin-10 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-10 release|bioassay" ; a owl:Class ; rdfs:label "cell culture analyte detection bioassay measuring epitope specific interleukin-10 production by T cells" ; rdfs:subClassOf obo:OBI_0000904, obo:OBI_0001209 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000904 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032613 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001221 obo:IAO_0000111 "ChIP-chip by SNP array assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A ChIP-ChIP assay in which immunoprecipitated chromatin is run on a SNP array to detect polymorphism specific DNA elements in the isolated chromatin" ; obo:IAO_0000117 "ArrayExpress production team" ; obo:IAO_0000119 "EFO:0002764" ; a owl:Class ; rdfs:label "ChIP-chip by SNP array assay" ; rdfs:subClassOf obo:OBI_0001248, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001204 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001204 ] ) ] . obo:OBI_0001222 obo:IAO_0000111 "ELISA measuring epitope specific RANTES production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects RANTES production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL5/RANTES release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific RANTES production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001232 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071609 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001223 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific interleukin-1 beta production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects interleukin-1 beta production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-1b release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific interleukin-1 beta production by T cells" ; rdfs:subClassOf obo:OBI_0001449, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032611 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001224 obo:IAO_0000111 "Cytopeia" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Karin Breuer" ; obo:IAO_0000119 "WEB:http://www.cytopeia.com/@2011/04/11" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Cytopeia" . obo:OBI_0001225 obo:IAO_0000111 "genetic population background information"@en ; obo:IAO_0000112 "genotype information 'C57BL/6J Hnf1a+/-' in this case, C57BL/6J is the genetic population background information"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a genetic characteristics information which is a part of genotype information that identifies the population of organisms"@en ; obo:IAO_0000116 "proposed and discussed on San Diego OBI workshop, March 2011"@en ; obo:IAO_0000117 "Group: OBI group"@en ; obo:IAO_0000119 "Group: OBI group"@en ; a owl:Class ; rdfs:label "genetic population background information"@en ; rdfs:subClassOf obo:OBI_0001404, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0001305 ] . obo:OBI_0001226 obo:IAO_0000111 "environmental history design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which some aspect of the organism's environmental history is studied, such as exposure to teratogen, radiation, climate etc." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_698 environmental_history_design" ; a owl:Class ; rdfs:label "environmental history design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000015 ] . obo:OBI_0001227 obo:IAO_0000111 "ELISPOT assay measuring epitope specific interleukin-6 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunospot assay that detects interleukin-6 production by T cells" ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-6 release|ELISPOT" ; a owl:Class ; rdfs:label "ELISPOT assay measuring epitope specific interleukin-6 production by T cells" ; rdfs:subClassOf obo:OBI_0001451, obo:OBI_0600031 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600031 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032635 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001228 obo:IAO_0000111 "in vivo assay measuring epitope specific helper T cell enhancement of a B cell mediated immune response" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific helper activity assay that detects the ability of a T cell epitope to enhance an antibody response." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "antibody help|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring epitope specific helper T cell enhancement of a B cell mediated immune response" ; rdfs:subClassOf obo:OBI_0001495 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0035399 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] ) ] . obo:OBI_0001229 obo:IAO_0000111 "plasmon resonance assay measuring the dissociation constant [KD] of a T cell epitope:MHC:TCR complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A surface plasmon resonance binding assay that measures the dissociation constant [KD] of an epitope:MHC complex binding with a T cell receptor." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "dissociation constant KD|surface plasmon resonance (SPR)|nM" ; a owl:Class ; rdfs:label "plasmon resonance assay measuring the dissociation constant [KD] of a T cell epitope:MHC:TCR complex" ; rdfs:subClassOf obo:OBI_0000923, obo:OBI_0002097 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000923 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001536 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_1110057 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000065 ; owl:onProperty obo:IAO_0000039 ] ] ) ] . obo:OBI_0001230 obo:IAO_0000111 "assay measuring epitope specific interleukin-5 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interleukin-5 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-5 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interleukin-5 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032634 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001231 obo:IAO_0000111 "ELISA measuring epitope specific transforming growth factor-beta production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects transforming growth factor-beta production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TGFb release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific transforming growth factor-beta production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001264 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071604 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001232 obo:IAO_0000111 "assay measuring epitope specific RANTES production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects RANTES production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL5/RANTES release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific RANTES production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071609 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001233 obo:IAO_0000111 "assay measuring epitope specific granulocyte macrophage colony stimulating factor production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects granulocyte macrophage colony stimulating factor production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "GM-CSF release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific granulocyte macrophage colony stimulating factor production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032604 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001234 obo:IAO_0000111 "epigenetic modification identification objective"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A molecular feature identification objective that aims to detect epigenetic modifications, such as DNA methylation, histone modifications."@en ; obo:IAO_0000117 "Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "Person: Chris Stoeckert"@en ; a owl:Class ; rdfs:label "epigenetic modification identification objective"@en ; rdfs:subClassOf obo:OBI_0000131 . obo:OBI_0001235 obo:IAO_0000111 "transcription profiling by tiling array assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A transcription profiling by array assay that uses a tiling path array." ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "EFO:0002769" ; a owl:Class ; rdfs:label "transcription profiling by tiling array assay" ; rdfs:subClassOf obo:OBI_0001463, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001307 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001307 ] ) ] . obo:OBI_0001236 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-22 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-22 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-22 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-22 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001217 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032626 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001237 obo:IAO_0000111 "assay measuring epitope specific interleukin-21 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interleukin-21 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-21 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interleukin-21 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032625 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001238 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-9 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-9 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-9 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-9 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001253 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032638 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001239 obo:IAO_0000111 "transcription profiling by high throughput sequencing design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which sequencing technology (e.g. Solexa/454) is used to generate RNA sequence, analyse the transcibed regions of the genome, and/or to quantitate transcript abundance" ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "Group: ArrayExpress production team" ; a owl:Class ; rdfs:label "transcription profiling by high throughput sequencing design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001331 ] . obo:OBI_0001240 obo:IAO_0000111 "intracellular cytokine staining assay measuring epitope specific interleukin-6 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects interleukin-6 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-6 release|ICS" ; a owl:Class ; rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-6 production by T cells" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0001451 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032635 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001241 obo:IAO_0000111 "cell culture analyte detection bioassay measuring epitope specific interleukin-4 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A reporter cell line analyte detection bioassay that detects interleukin-4 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-4 release|bioassay" ; a owl:Class ; rdfs:label "cell culture analyte detection bioassay measuring epitope specific interleukin-4 production by T cells" ; rdfs:subClassOf obo:OBI_0000904, obo:OBI_0001450 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000904 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032633 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001242 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific tumor necrosis factor alpha production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects tumor necrosis factor alpha production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TNFa release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific tumor necrosis factor alpha production by T cells" ; rdfs:subClassOf obo:OBI_0001416, obo:OBI_0001788 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032640 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001243 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific monocyte chemotactic protein-1 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects monocyte chemotactic protein-1 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL2/MCP-1 release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific monocyte chemotactic protein-1 production by T cells" ; rdfs:subClassOf obo:OBI_0001465, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071605 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001244 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-23 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-23 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-23 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-23 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001363 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032627 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001245 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific perforin release" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acids with complementary probes assay that detects epitope specific perforin release by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "perforin release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific perforin release" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001497 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0003317 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001246 obo:IAO_0000111 "ELISA measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects tumor necrosis factor superfamily cytokine production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TNF release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001400 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071706 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001247 obo:IAO_0000111 "genotyping by high throughput sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A genotyping assay that uses a high througput sequencer" ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "EFO:0002771" ; a owl:Class ; rdfs:label "genotyping by high throughput sequencing assay" ; rdfs:subClassOf obo:OBI_0000435, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400103 ] ) ] . obo:OBI_0001248 obo:IAO_0000111 "ChIP-chip assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay in which chromatin is immunoprecipitated and subsequently analyzed using a DNA microarray to identify which parts of DNA are part of the isolated chromatin" ; obo:IAO_0000117 "Bjoern Petesr", "James Malone" ; obo:IAO_0000118 "ChIP-on-chip assay" ; obo:IAO_0000119 "url:http://en.wikipedia.org/wiki/ChIP-on-chip" ; a owl:Class ; rdfs:label "ChIP-chip assay" ; rdfs:subClassOf obo:OBI_0001954 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001954 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400148 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400148 ] ) ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001985 obo:OBI_0003368 ) ] ] ) ] . obo:OBI_0001249 obo:IAO_0000111 "epitope specific T cell tolerance induction" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of T cell tolerance induction resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific T cell tolerance induction" ; rdfs:subClassOf obo:GO_0002517, obo:OBI_0001201 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0002517 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001250 obo:IAO_0000111 "obsolete intracellular material detection by flow cytometry assay of epitope specific cytotoxic T cell degranulation" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An intracellular material detection by flow cytometry assay that measures epitope specific cytotoxic T cell degranulation" ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:OBI_0000916 ; obo:OBI_9991118 "T cell degranulation by intracellular staining" ; a owl:Class ; rdfs:label "obsolete intracellular material detection by flow cytometry assay of epitope specific cytotoxic T cell degranulation" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0001251 obo:IAO_0000111 "assay measuring epitope specific interleukin-13 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interleukin-13 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-13 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interleukin-13 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032616 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001252 obo:IAO_0000111 "array platform variation design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which the array platform is compared, e.g. Agilent versus Affymetrix." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_899 array_platform_variation_design" ; a owl:Class ; rdfs:label "array platform variation design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000208 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000052 ] ) ] ] . obo:OBI_0001253 obo:IAO_0000111 "assay measuring interleukin-9 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interleukin-9 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-9 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring interleukin-9 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032638 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001254 obo:IAO_0000111 "epitope specific interleukin-3 production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of interleukin-3 production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific interleukin-3 production by T cells" ; rdfs:subClassOf obo:GO_0032632, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032632 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001255 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-5 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-5 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-5 release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-5 production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001230 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032634 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001256 obo:IAO_0000111 "epitope specific lymphotoxin A production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of lymphotoxin A production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific lymphotoxin A production by T cells" ; rdfs:subClassOf obo:GO_0032641, obo:OBI_0001351 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032641 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001257 obo:IAO_0000111 "epitope specific interleukin-1 alpha production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of interleukin-1 alpha production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific interleukin-1 alpha production by T cells" ; rdfs:subClassOf obo:GO_0032610, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032610 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001258 obo:IAO_0000111 "ChIP-seq design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design which aims to identify protein and DNA interactions using a combination of chromatin immunoprecipitation and high throughput sequencing. Massively parallel sequence analyses are used in conjunction with whole-genome sequence databases to analyze the interaction pattern of any protein with DNA, or the pattern of any epigenetic chromatin modifications." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Chip-Sequencing" ; a owl:Class ; rdfs:label "ChIP-seq design" ; rdfs:subClassOf obo:OBI_0001425, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001234 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001398 ] . obo:OBI_0001259 obo:IAO_0000111 "translational bias design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that characterizes the association of transcripts and translation machinery." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_939 translational_bias_design" ; a owl:Class ; rdfs:label "translational bias design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000015 ] . obo:OBI_0001260 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-3 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-3 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-3 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-3 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001406 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032632 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001261 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-1 alpha production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-1 alpha production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-1a release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-1 alpha production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001388 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032610 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001262 obo:IAO_0000111 "epitope specific interleukin-27 production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of interleukin-27 production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific interleukin-27 production by T cells" ; rdfs:subClassOf obo:GO_0032631, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032631 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001263 obo:IAO_0000111 "in vivo assay measuring epitope specific helper T cell enhancement of a T cell mediated immune response" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific helper activity assay that detects the ability of a T cell epitope to enhance a T cell response." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "T cell help|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring epitope specific helper T cell enhancement of a T cell mediated immune response" ; rdfs:subClassOf obo:OBI_0001495 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0035398 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] ) ] . obo:OBI_0001264 obo:IAO_0000111 "assay measuring epitope specific transforming growth factor-beta production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects transforming growth factor-beta production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TGFb release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific transforming growth factor-beta production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071604 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001265 obo:IAO_0000111 "FWER adjusted p-value" ; obo:IAO_0000112 "http://ugrad.stat.ubc.ca/R/library/LPE/html/mt.rawp2adjp.html"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A quantitative confidence value resulting from a multiple testing error correction method which adjusts the p-value used as input to control for Type I error in the context of multiple pairwise tests"@en ; obo:IAO_0000117 "PERS:Philippe Rocca-Serra"@en ; obo:IAO_0000119 "adapted from wikipedia (http://en.wikipedia.org/wiki/Familywise_error_rate)"@en ; a owl:Class ; rdfs:label "FWER adjusted p-value" ; rdfs:subClassOf obo:OBI_0000071 . obo:OBI_0001266 obo:IAO_0000111 "DNA methylation profiling by high throughput sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA methylation profiling assay in which the methylation state of DNA is determined and can be compared between samples using sequencing based technology" ; obo:IAO_0000117 "ArrayExpress production team", "Helen Parkinson", "James Malone" ; obo:IAO_0000119 "EFO:0002761" ; a owl:Class ; rdfs:label "DNA methylation profiling by high throughput sequencing assay" ; rdfs:subClassOf obo:OBI_0000634, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400103 ] ) ] . obo:OBI_0001267 obo:IAO_0000111 "epitope specific transforming growth factor-beta production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of transforming growth factor-beta production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific transforming growth factor-beta production by T cells" ; rdfs:subClassOf obo:GO_0071604, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0071604 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001268 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-12 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-12 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-12 release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-12 production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001391 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032615 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001269 obo:IAO_0000111 "assay measuring epitope specific cytotoxic T cell degranulation" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope dependent biological activity assay that detects cytotoxic T cell degranulation." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "degranulation|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific cytotoxic T cell degranulation" ; rdfs:subClassOf obo:OBI_0002055 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043316 ] [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001270 obo:IAO_0000111 "cell culture analyte detection bioassay measuring epitope specific transforming growth factor-beta production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A reporter cell line analyte detection bioassay that detects transforming growth factor-beta production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TGFb release|bioassay" ; a owl:Class ; rdfs:label "cell culture analyte detection bioassay measuring epitope specific transforming growth factor-beta production by T cells" ; rdfs:subClassOf obo:OBI_0000904, obo:OBI_0001264 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000904 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071604 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001271 obo:IAO_0000111 "RNA-seq assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An RNA sequencing assay that determines an RNA sequence by analyzing the transcibed regions of the genome and or to quantitate transcript abundance." ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000118 "transcription profiling by high throughput sequencing" ; obo:IAO_0000119 "EFO:0002770" ; a owl:Class ; rdfs:label "RNA-seq assay" ; rdfs:subClassOf obo:OBI_0001177, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0010467 ] ] . obo:OBI_0001272 obo:IAO_0000111 "ELISPOT assay measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunospot assay that detects tumor necrosis factor superfamily cytokine production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TNF release|ELISPOT" ; a owl:Class ; rdfs:label "ELISPOT assay measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ; rdfs:subClassOf obo:OBI_0001400, obo:OBI_0600031 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600031 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071706 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001273 obo:IAO_0000111 "cell culture analyte detection bioassay measuring epitope specific interleukin-5 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A reporter cell line analyte detection bioassay that detects interleukin-5 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-5 release|bioassay" ; a owl:Class ; rdfs:label "cell culture analyte detection bioassay measuring epitope specific interleukin-5 production by T cells" ; rdfs:subClassOf obo:OBI_0000904, obo:OBI_0001230 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000904 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032634 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001274 obo:IAO_0000111 "genotyping by array assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A genotyping assay that uses an array" ; obo:IAO_0000117 "ArrayExpress production team" ; obo:IAO_0000119 "EFO:0002767" ; a owl:Class ; rdfs:label "genotyping by array assay" ; rdfs:subClassOf obo:OBI_0000435, obo:OBI_0001985, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400148 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400148 ] ) ] . obo:OBI_0001275 obo:IAO_0000111 "epitope specific interleukin-16 production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of interleukin-16 production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific interleukin-16 production by T cells" ; rdfs:subClassOf obo:GO_0032619, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032619 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001276 obo:IAO_0000111 "assay measuring epitope specific chemokine (C-C motif) ligand 1 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects production of chemokine (C-C motif) ligand 1 by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL1/TCA-3 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific chemokine (C-C motif) ligand 1 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071610 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001277 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-2 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-2 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-2 release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-2 production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001445 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032623 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001278 obo:IAO_0000111 "DNA methylation profiling by array design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which the methylation state of DNA is determined and is compared between samples using array technology." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "GROUP: ArrayExpress production team" ; a owl:Class ; rdfs:label "DNA methylation profiling by array design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001234 ] . obo:OBI_0001279 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-22 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-22 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-22 release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-22 production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001217 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032626 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001280 obo:IAO_0000111 "assay measuring epitope specific interleukin-16 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interleukin-16 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-16 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interleukin-16 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032619 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001281 obo:IAO_0000111 "ELISA measuring epitope specific IP-10 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects IP-10 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CXCL10/IP-10 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific IP-10 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001308 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071612 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001282 obo:IAO_0000111 "translation profiling assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay in which surface-bound, translationally competent ribosome complexes are used to generate a translation profile for mRNA, which mRNA may be a single molecular species, or a combination of species, including complex mixtures such as those found in the set of mRNAs isolated from a cell or tissue. One or more components of the surface-bound ribosome complex may be labeled at specific positions to permit analysis of multiple or single molecules for determination of ribosomal conformational changes and translation kinetics. Translation profiles are used as the basis for comparison of an mRNA or set of mRNA species. The translation profile can be used to determine such characteristics as kinetics of initiation, kinetic of elongation, identity of the polypeptide product, and the like. Analysis of translation profiles may be used to determine differential gene expression, optimization of mRNA sequences for expression, screening drug candidates for an effect on translation." ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "EFO:0001033" ; a owl:Class ; rdfs:label "translation profiling assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000131 ] . obo:OBI_0001283 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-15 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-15 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-15 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-15 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001292 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032618 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001284 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific interleukin-12 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects interleukin-12 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-12 release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific interleukin-12 production by T cells" ; rdfs:subClassOf obo:OBI_0001391, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032615 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001285 obo:IAO_0000111 "in vitro design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that is done in a test tube or a culture dish, e.g. A bacterial invasion assay in an established cell culture." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_347 in_vitro_design" ; a owl:Class ; rdfs:label "in vitro design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0001286 obo:IAO_0000111 "RNAi profiling by array design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which experiment double stranded RNA is synthesized with a sequence complementary to a gene(s) of interest and introduced into a cell or organism, where it is recognized as exogenous genetic material and activates the RNAi pathway resulting in knockdown of the transcripts and providing a means to study downstream changes in gene expression." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "Group: ArrayExpress production team" ; a owl:Class ; rdfs:label "RNAi profiling by array design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000131 ] . obo:OBI_0001287 obo:IAO_0000111 "Exalpha Biological" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Karin Breuer" ; obo:IAO_0000119 "WEB:http://www.exalpha.com/@2011/04/11" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Exalpha Biological" . obo:OBI_0001288 obo:IAO_0000111 "ELISA measuring epitope specific lymphotoxin A production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects lymphotoxin A production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "lymphotoxin A/TNFb release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific lymphotoxin A production by T cells" ; rdfs:subClassOf obo:OBI_0001246, obo:OBI_0001327 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032641 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001289 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific interleukin-5 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects interleukin-5 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-5 release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific interleukin-5 production by T cells" ; rdfs:subClassOf obo:OBI_0001230, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032634 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001290 obo:IAO_0000111 "transcription profiling by array design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that identifies forms and abundance of transcripts in the genome using microarray technology." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_533 transcript_identification_design" ; a owl:Class ; rdfs:label "transcription profiling by array design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001331 ] . obo:OBI_0001291 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-17 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-17 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-17 release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-17 production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001295 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032620 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001292 obo:IAO_0000111 "assay measuring epitope specific interleukin-15 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interleukin-15 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-15 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interleukin-15 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032618 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001293 obo:IAO_0000111 "disease state design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which the pathological condition of a part, organ, or system of an organism is studied. The etiology may be from infection, genetic defect, or environmental stress." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_902 disease_state_design" ; a owl:Class ; rdfs:label "disease state design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000268 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OGMS_0000031 ] ) ] ] . obo:OBI_0001294 obo:IAO_0000111 "wild type organism genotype information"@en ; obo:IAO_0000112 "C57BL/6J wild type"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a genotype information about an organism and includes information that there are no known modifications to the genetic background. Generally it is the genotype information of a representative individual from a class of organisms."@en ; obo:IAO_0000116 "proposed and discussed on San Diego OBI workshop, March 2011"@en ; obo:IAO_0000117 "Group: OBI group"@en ; obo:IAO_0000119 "Group: OBI group"@en ; a owl:Class ; rdfs:label "wild type organism genotype information"@en ; rdfs:subClassOf obo:OBI_0001305 . obo:OBI_0001295 obo:IAO_0000111 "assay measuring epitope specific interleukin-17 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interleukin-17 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-17 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interleukin-17 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032620 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001296 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific interleukin-17 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects interleukin-17 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-17 release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific interleukin-17 production by T cells" ; rdfs:subClassOf obo:OBI_0001295, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032620 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001297 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific interleukin-10 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects interleukin-10 production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-10 release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific interleukin-10 production by T cells" ; rdfs:subClassOf obo:OBI_0001209, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032613 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001298 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-21 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-21 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-21 release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-21 production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001237 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032625 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001299 obo:IAO_0000111 "intracellular cytokine staining assay measuring epitope specific interleukin-5 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects interleukin-5 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-5 release|ICS" ; a owl:Class ; rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-5 production by T cells" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0001230 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032634 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001300 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific interleukin-2 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects interleukin-2 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-2 release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific interleukin-2 production by T cells" ; rdfs:subClassOf obo:OBI_0001445, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032623 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001301 obo:IAO_0000111 "cell culture analyte detection bioassay measuring epitope specific interleukin-16 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A reporter cell line analyte detection bioassay that detects interleukin-16 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-16 release|bioassay" ; a owl:Class ; rdfs:label "cell culture analyte detection bioassay measuring epitope specific interleukin-16 production by T cells" ; rdfs:subClassOf obo:OBI_0000904, obo:OBI_0001280 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000904 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032619 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001302 obo:IAO_0000111 "ELISA measuring epitope specific macrophage inflammatory protein-1 alpha production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects macrophage inflammatory protein-1 alpha production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL3/MIP-1a release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific macrophage inflammatory protein-1 alpha production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001333 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071608 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001303 obo:IAO_0000111 "intracellular cytokine staining assay measuring epitope specific granulocyte macrophage colony-stimulating factor production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects granulocyte macrophage colony stimulating factor production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "GM-CSF release|ICS" ; a owl:Class ; rdfs:label "intracellular cytokine staining assay measuring epitope specific granulocyte macrophage colony-stimulating factor production by T cells" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0001233 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032604 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001304 obo:IAO_0000111 "RNAi profiling by array assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay in which double stranded RNA is synthesized with a sequence complementary to a gene(s) of interest and introduced into a cell or organism, where it is recognized as exogenous genetic material and activates the RNAi pathway resulting in knockdown of the transcripts and providing a means to study downstream changes in gene expression." ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "EFO:0001030" ; a owl:Class ; rdfs:label "RNAi profiling by array assay" ; rdfs:subClassOf obo:OBI_0001985, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400148 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400148 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33697 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33697 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000131 ] . obo:OBI_0001305 obo:IAO_0000111 "genotype information"@en ; obo:IAO_0000112 "Genotype information can be: Mus musculus wild type (in this case the genetic population background information is Mus musculus), C57BL/6J Hnf1a+/- (in this case, C57BL/6J is the genetic population background information and Hnf1a+/- is the allele information"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a genetic characteristics information that is about the genetic material of an organism and minimally includes information about the genetic background and can in addition contain information about specific alleles, genetic modifications, etc."@en ; obo:IAO_0000116 "discussed on San Diego OBI workshop, March 2011"@en ; obo:IAO_0000117 "Group: OBI group"@en ; obo:IAO_0000119 "Group: OBI group"@en ; a owl:Class ; rdfs:label "genotype information"@en ; rdfs:subClassOf obo:OBI_0001404, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001225 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001364 ] ) ] . obo:OBI_0001306 obo:IAO_0000111 "RNA stability design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that examines the stability and/or decay of RNA transcripts." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_553 RNA_stability_design" ; a owl:Class ; rdfs:label "RNA stability design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000131 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CHEBI_33697 ] ) ] ] . obo:OBI_0001307 obo:IAO_0000111 "tiling microarray" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA microarray which has short fragments of nucleic acid immobilized on a substrate. These are designed to cover the whole genome of the target species. Tiling arrays are used to determine genome binding in ChIP assays or to identify transcribed regions." ; obo:IAO_0000117 "Person: Helen Parkinson" ; obo:IAO_0000118 "genome tiling array" ; obo:IAO_0000119 "EFO_0002704: tiling array" ; a owl:Class ; rdfs:label "tiling microarray" ; rdfs:subClassOf obo:OBI_0400148 . obo:OBI_0001308 obo:IAO_0000111 "assay measuring epitope specific IP-10 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects IP-10 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CXCL10/IP-10 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific IP-10 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071612 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001309 obo:IAO_0000111 "intracellular cytokine staining assay measuring epitope specific interleukin-13 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects interleukin-13 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-13 release|ICS" ; a owl:Class ; rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-13 production by T cells" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0001251 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032616 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001310 obo:IAO_0000111 "species comparison design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that assays differences between distinct species." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_675 species_design" ; a owl:Class ; rdfs:label "species comparison design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000268 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0100026 ] ) ] ] . obo:OBI_0001311 obo:IAO_0000111 "X-ray crystallography assay determining the 3D structure of a T cell epitope:MHC:TCR complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A X-ray crystallography 3D molecular structure determination assay that characterizes the 3-dimensional molecular structure of a T cell epitope:MHC:TCR complex." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "3D structure|x-ray crystallography|angstroms" ; a owl:Class ; rdfs:label "X-ray crystallography assay determining the 3D structure of a T cell epitope:MHC:TCR complex" ; rdfs:subClassOf obo:OBI_0000912, obo:OBI_0001999 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000912 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001155 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0003120 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000019 ; owl:onProperty obo:IAO_0000039 ] ] ) ] . obo:OBI_0001312 obo:IAO_0000111 "Apogee Flow Systems" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Karin Breuer" ; obo:IAO_0000119 "WEB:http://www.apogeeflow.com/@2011/04/11" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Apogee Flow Systems" . obo:OBI_0001313 obo:IAO_0000111 "transcription profiling by RT-PCR design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design which aims to examine the transcriptome of a biological sample by reverse transcription PCR (RT-PCR)." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "Group: ArrayExpress production team" ; a owl:Class ; rdfs:label "transcription profiling by RT-PCR design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001331 ] . obo:OBI_0001314 obo:IAO_0000111 "epitope specific T cell enhancement of B cell mediated immune response" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of T cell enhancement of B cell mediated immune response resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific T cell enhancement of B cell mediated immune response" ; rdfs:subClassOf obo:GO_0035399 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0035399 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001315 obo:IAO_0000111 "ELISA measuring epitope specific chemokine (C-C motif) ligand 1 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects chemokine (C-C motif) ligand 1 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL1/TCA-3 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific chemokine (C-C motif) ligand 1 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001276 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071610 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001316 obo:IAO_0000111 "epitope specific interleukin-21 production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of interleukin-21 production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific interleukin-21 production by T cells" ; rdfs:subClassOf obo:GO_0032625, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032625 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001317 obo:IAO_0000111 "flow cytometry assay measuring cell-cell binding of a T cell epitope:MHC:TCR complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that measures the cell-cell binding of an epitope:MHC complex binding with a T cell receptor." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "T cell- APC binding|binding assay" ; a owl:Class ; rdfs:label "flow cytometry assay measuring cell-cell binding of a T cell epitope:MHC:TCR complex" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_1110124, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0003141 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_1110057 ] ] . obo:OBI_0001318 obo:IAO_0000111 "proteomic profiling by array assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that detects proteins in a sample (quantified or otherwise analyzed), e.g. antibody profiling using an array based technology." ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "EFO:0002765" ; a owl:Class ; rdfs:label "proteomic profiling by array assay" ; rdfs:subClassOf obo:OBI_0001985, obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400149 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400149 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000000001 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000131 ] . obo:OBI_0001319 obo:IAO_0000111 "cell culture analyte detection bioassay measuring epitope specific interferon-gamma production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A reporter cell line analyte detection bioassay that detects interferon-gamma production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IFNg release|bioassay" ; a owl:Class ; rdfs:label "cell culture analyte detection bioassay measuring epitope specific interferon-gamma production by T cells" ; rdfs:subClassOf obo:OBI_0000904, obo:OBI_0001414 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000904 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032609 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001320 obo:IAO_0000111 "Exbio Antibodies" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Karin Breuer" ; obo:IAO_0000119 "WEB:http://www.exbio.cz/@2011/04/11" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Exbio Antibodies" . obo:OBI_0001321 obo:IAO_0000111 "Becton Dickinson (BD Biosciences)" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Karin Breuer" ; obo:IAO_0000119 "WEB:http://www.bdbiosciences.com/@2011/04/11" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Becton Dickinson (BD Biosciences)" . obo:OBI_0001322 obo:IAO_0000111 "ELISPOT assay measuring epitope specific granzyme B release by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunospot assay that detects epitope specific granzyme B release by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "granzyme B release|ELISPOT" ; a owl:Class ; rdfs:label "ELISPOT assay measuring epitope specific granzyme B release by T cells" ; rdfs:subClassOf obo:OBI_0001436, obo:OBI_0600031 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600031 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0003319 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001323 obo:IAO_0000111 "microRNA profiling by array design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which a microRNA array is used to analyse the microRNA component of the transcriptome." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "Group: ArrayExpress production team" ; a owl:Class ; rdfs:label "microRNA profiling by array design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001331 ] . obo:OBI_0001324 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific tolerance induction" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An efficacy of T cell epitope intervention experiment that uses a tolerance induction intervention experiment." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "tolerance|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific tolerance induction" ; rdfs:subClassOf obo:OBI_0001484, obo:OBI_0001488 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001488 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0002517 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] ) ] . obo:OBI_0001325 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific RANTES production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects RANTES production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL5/RANTES release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific RANTES production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001232 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071609 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001326 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific interleukin-4 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects interleukin-4 production by T cells" ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-4 release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific interleukin-4 production by T cells" ; rdfs:subClassOf obo:OBI_0001450, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032633 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001327 obo:IAO_0000111 "assay measuring epitope specific lymphotoxin A production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects lymphotoxin A production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "lymphotoxin A/TNFb release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific lymphotoxin A production by T cells" ; rdfs:subClassOf obo:OBI_0001400 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032641 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001328 obo:IAO_0000111 "organism development design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that assays events associated with development. Development applies to organism(s) acquiring a mature state." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_892 development_or_differentiation_design" ; a owl:Class ; rdfs:label "organism development design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000268 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000105 [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom obo:OBI_0100026 ] ) ] ] ) ] ] . obo:OBI_0001329 obo:IAO_0000111 "family history design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which the family history such as traits, characteristics, susceptibility to disease is studied." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_544 family_history_design" ; a owl:Class ; rdfs:label "family history design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000268 ] . obo:OBI_0001330 obo:IAO_0000111 "ELISA measuring epitope specific chemokine (C-X-C motif) ligand 9 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects chemokine (C-X-C motif) ligand 9 production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CXCL9/MIG release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific chemokine (C-X-C motif) ligand 9 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001459 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0035393 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001331 obo:IAO_0000111 "transcription profiling identification objective"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A molecular feature identification objective that aims to characterize the abundance of transcripts"@en ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "Group: Penn Group"@en ; a owl:Class ; rdfs:label "transcription profiling identification objective"@en ; rdfs:subClassOf obo:OBI_0000131 . obo:OBI_0001332 obo:IAO_0000111 "DNA methylation profiling by array assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA methylation profiling assay in which the methylation state of DNA is determined and can be compared between samples using array technology" ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "EFO:0002759" ; a owl:Class ; rdfs:label "DNA methylation profiling by array assay" ; rdfs:subClassOf obo:OBI_0000634, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400148 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400148 ] ) ] . obo:OBI_0001333 obo:IAO_0000111 "assay measuring epitope specific macrophage inflammatory protein-1 alpha production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects macrophage inflammatory protein-1 alpha production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL3/MIP-1a release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific macrophage inflammatory protein-1 alpha production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071608 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001334 obo:IAO_0000111 "epitope specific granulocyte colony stimulating factor production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of granulocyte colony stimulating factor production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific granulocyte colony stimulating factor production by T cells" ; rdfs:subClassOf obo:GO_0071611, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0071611 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001335 obo:IAO_0000111 "microRNA profiling by array assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that analyses the microRNA component of the transcriptome using a microRNA array." ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "EFO:0000753" ; a owl:Class ; rdfs:label "microRNA profiling by array assay" ; rdfs:subClassOf obo:OBI_0001926, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400148 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400148 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33697 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33697 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33697 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000101 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:SO_0000276 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001331 ] . obo:OBI_0001336 obo:IAO_0000111 "quality control testing design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which some aspects of the experiment is quality controlled for the purposes of quality assurance." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_981 quality_control_testing_design" ; a owl:Class ; rdfs:label "quality control testing design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0001337 obo:IAO_0000111 "clinical history design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that the organism's clinical history of diagnosis, treatments, e.g. vaccinations, surgery etc. is studied." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_832 clinical_history_design" ; a owl:Class ; rdfs:label "clinical history design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000268 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OGMS_0000015 ] ) ] ] . obo:OBI_0001338 obo:IAO_0000111 "Dako Cytomation" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Karin Breuer" ; obo:IAO_0000119 "WEB:http://www.dakousa.com/@2011/04/11" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Dako Cytomation" . obo:OBI_0001339 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-4 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-4 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-4 release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-4 production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001450 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032633 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001340 obo:IAO_0000111 "Millipore" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Karin Breuer" ; obo:IAO_0000119 "WEB:http://www.guavatechnologies.com/@2011/04/11" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Millipore" . obo:OBI_0001341 obo:IAO_0000111 "cell culture analyte detection bioassay measuring epitope specific granulocyte macrophage colony-stimulating factor production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A reporter cell line analyte detection bioassay that detects granulocyte macrophage colony stimulating factor production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "GM-CSF release|bioassay" ; a owl:Class ; rdfs:label "cell culture analyte detection bioassay measuring epitope specific granulocyte macrophage colony-stimulating factor production by T cells" ; rdfs:subClassOf obo:OBI_0000904, obo:OBI_0001233 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000904 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032604 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001342 obo:IAO_0000111 "intracellular cytokine staining assay measuring epitope specific interleukin-21 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects interleukin-21 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-21 release|ICS" ; a owl:Class ; rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-21 production by T cells" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0001237 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032625 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001343 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific monocyte chemotactic protein-1 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects monocyte chemotactic protein-1 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL2/MCP-1 release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific monocyte chemotactic protein-1 production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001465 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071605 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001344 obo:IAO_0000111 "ELISA measuring epitope specific monocyte chemotactic protein-1 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects monocyte chemotactic protein-1 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL2/MCP-1 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific monocyte chemotactic protein-1 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001465 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071605 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001345 obo:IAO_0000111 "assay measuring epitope specific chemokine (C-C motif) ligand 4 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects chemokine (C-C motif) ligand 4 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL4/MIP-1b release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific chemokine (C-C motif) ligand 4 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071606 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001346 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-21 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-21 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-21 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-21 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001237 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032625 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001347 obo:IAO_0000111 "Antigenix" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Karin Breuer" ; obo:IAO_0000119 "WEB:http://www.antigenix.com/@2011/04/11" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Antigenix" . obo:OBI_0001348 obo:IAO_0000111 "in vivo skin test assay measuring T cell epitope specific type IV hypersensitivity" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An efficacy of T cell epitope intervention experiment that detects epitope specific type IV hypersensitivity." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "type IV hypersensitivity (DTH)|in vivo skin test" ; a owl:Class ; rdfs:label "in vivo skin test assay measuring T cell epitope specific type IV hypersensitivity" ; rdfs:subClassOf obo:OBI_0001178, obo:OBI_0001484 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001178 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001806 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] ) ] . obo:OBI_0001349 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific interleukin-13 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects interleukin-13 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-13 release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific interleukin-13 production by T cells" ; rdfs:subClassOf obo:OBI_0001251, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032616 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001350 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific interferon-gamma production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects interferon-gamma production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IFNg release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interferon-gamma production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001414 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032609 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001351 obo:IAO_0000111 "epitope specific tumor necrosis factor superfamily cytokine production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of tumor necrosis factor superfamily cytokine production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific tumor necrosis factor superfamily cytokine production by T cells" ; rdfs:subClassOf obo:GO_0071706, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0071706 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001352 obo:IAO_0000111 "allele information"@en ; obo:IAO_0000112 "genotype information 'C57BL/6J Hnf1a+/-' in this case, Hnf1a+/- is the allele information"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a genetic alteration information that about one of two or more alternative forms of a gene or marker sequence and differing from other alleles at one or more mutational sites based on sequence. Polymorphisms are included in this definition."@en ; obo:IAO_0000116 "discussed on San Diego OBI workshop, March 2011"@en ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "MO_58 Allele" ; a owl:Class ; rdfs:label "allele information"@en ; rdfs:subClassOf obo:OBI_0001364, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0001305 ] [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:SO_0000001 ] ) ] . obo:OBI_0001353 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific tumor necrosis factor alpha production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects tumor necrosis factor alpha production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TNFa release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific tumor necrosis factor alpha production by T cells" ; rdfs:subClassOf obo:OBI_0001368, obo:OBI_0001416 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032640 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001354 obo:IAO_0000111 "ELISPOT assay measuring epitope specific interleukin-17 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunospot assay that detects interleukin-17 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-17 release|ELISPOT" ; a owl:Class ; rdfs:label "ELISPOT assay measuring epitope specific interleukin-17 production by T cells" ; rdfs:subClassOf obo:OBI_0001295, obo:OBI_0600031 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600031 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032620 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001355 obo:IAO_0000111 "Partec" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Karin Breuer" ; obo:IAO_0000119 "WEB:http://www.partec.de/@2011/04/11" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Partec" . obo:OBI_0001356 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific interferon-beta production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects interferon-beta production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IFNb release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interferon-beta production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001390 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032608 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001357 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific granulocyte macrophage colony-stimulating factor production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects granulocyte macrophage colony stimulating factor production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "GM-CSF release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific granulocyte macrophage colony-stimulating factor production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001233 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032604 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001358 obo:IAO_0000111 "post-transcriptional modification design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which a modification of the transcriptome, proteome (not genome) is made, for example RNAi, antibody targeting." ; obo:IAO_0000116 "post transcription modification design? or more clear RNAi design / antibody targeting design? need to check the use cases" ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_392 cellular_modification_design" ; a owl:Class ; rdfs:label "post-transcriptional modification design" ; rdfs:subClassOf obo:OBI_0000115, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000015 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000931 ] ) ] ] . obo:OBI_0001359 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-8 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-8 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-8 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-8 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001218 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032637 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001360 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific interleukin-6 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects interleukin-6 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-6 release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific interleukin-6 production by T cells" ; rdfs:subClassOf obo:OBI_0001451, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032635 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001361 obo:IAO_0000111 "transcription profiling by RT-PCR assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A transcription profiling assay that uses reverse transcription PCR (RT-PCR)." ; obo:IAO_0000117 "Anna Farne" ; obo:IAO_0000119 "EFO:0002943" ; a owl:Class ; rdfs:label "transcription profiling by RT-PCR assay" ; rdfs:subClassOf obo:OBI_0000424, obo:OBI_0002692, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000989 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000989 ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000552 ] . obo:OBI_0001362 obo:IAO_0000111 "epitope specific chemokine (C-C motif) ligand 4 production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of chemokine (C-C motif) ligand 4 production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific chemokine (C-C motif) ligand 4 production by T cells" ; rdfs:subClassOf obo:GO_0071606, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0071606 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001363 obo:IAO_0000111 "assay measuring epitope specific interleukin-23 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interleukin-23 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-23 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interleukin-23 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032627 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001364 obo:IAO_0000111 "genetic alteration information"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a genetic characteristics information that is about known changes or the lack thereof from the genetic background, including allele information, duplication, insertion, deletion, etc."@en ; obo:IAO_0000116 "proposed and discussed on San Diego OBI workshop, March 2011"@en ; obo:IAO_0000117 "Group: OBI group"@en ; obo:IAO_0000119 "Group: OBI group"@en ; a owl:Class ; rdfs:label "genetic alteration information"@en ; rdfs:subClassOf obo:OBI_0001404 . obo:OBI_0001365 obo:IAO_0000111 "cellular process design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that aims to study the processes that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_810 cellular_process_design" ; a owl:Class ; rdfs:label "cellular process design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000219 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0009987 ] ) ] ] . obo:OBI_0001366 obo:IAO_0000111 "epitope specific RANTES production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of RANTES production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific RANTES production by T cells" ; rdfs:subClassOf obo:GO_0071609, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0071609 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001367 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-10 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-10 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-10 release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-10 production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001209 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032613 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001368 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects tumor necrosis factor superfamily cytokine production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TNF release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ; rdfs:subClassOf obo:OBI_0001400, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071706 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001369 obo:IAO_0000111 "wild type allele information"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "an allele information that is about the allele found most frequently in natural populations, or in standard laboratory stocks for a given organism."@en ; obo:IAO_0000116 "discussed on San Diego OBI workshop, March 2011"@en ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "MO_605 genotype"@en ; a owl:Class ; rdfs:label "wild type allele information"@en ; rdfs:subClassOf obo:OBI_0001352 . obo:OBI_0001370 obo:IAO_0000111 "intracellular cytokine staining assay measuring epitope specific chemokine (C-C motif) ligand 4 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects chemokine (C-C motif) ligand 4 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL4/MIP-1b release|ICS" ; a owl:Class ; rdfs:label "intracellular cytokine staining assay measuring epitope specific chemokine (C-C motif) ligand 4 production by T cells" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0001345 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071606 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001371 obo:IAO_0000111 "epitope specific granzyme B production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of granzyme B production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific granzyme B production by T cells" ; rdfs:subClassOf obo:GO_0071613 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0071613 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001372 obo:IAO_0000111 "Beckman Coulter" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Karin Breuer" ; obo:IAO_0000119 "WEB:http://www.beckmancoulter.com/@2011/04/11" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Beckman Coulter" . obo:OBI_0001373 obo:IAO_0000111 "epitope specific interleukin-8 production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of interleukin-8 production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific interleukin-8 production by T cells" ; rdfs:subClassOf obo:GO_0032637, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032637 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001374 obo:IAO_0000111 "injury design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which the response of an organism(s) to injury or damage is studied." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_726 injury_design" ; a owl:Class ; rdfs:label "injury design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000268 ] . obo:OBI_0001375 obo:IAO_0000111 "Advanced Instruments Inc. (AI Companies)" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Karin Breuer" ; obo:IAO_0000119 "WEB:http://www.aicompanies.com/@2011/04/11" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Advanced Instruments Inc. (AI Companies)" . obo:OBI_0001376 obo:IAO_0000111 "intracellular cytokine staining assay measuring epitope specific interleukin-3 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects interleukin-3 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-3 release|ICS" ; a owl:Class ; rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-3 production by T cells" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0001406 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032632 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001377 obo:IAO_0000111 "organism status comparison design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that compares samples from live and dead organisms." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_841 organism_status_design" ; a owl:Class ; rdfs:label "organism status comparison design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000058 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:BFO_0000054 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0000873 obo:OBI_0000902 ) ] ] ) ] ] ] . obo:OBI_0001378 obo:IAO_0000111 "ELISA measuring epitope specific chemokine (C-C motif) ligand 4 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects chemokine (C-C motif) ligand 4 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL4/MIP-1b release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific chemokine (C-C motif) ligand 4 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001345 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071606 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001379 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific interferon-gamma production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects interferon-gamma production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IFNg release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific interferon-gamma production by T cells" ; rdfs:subClassOf obo:OBI_0001414, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032609 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001380 obo:IAO_0000111 "assay measuring epitope specific interleukin-18 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interleukin-18 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-18 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interleukin-18 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032621 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001381 obo:IAO_0000111 "epitope specific interleukin-23 production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of interleukin-23 production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific interleukin-23 production by T cells" ; rdfs:subClassOf obo:GO_0032627, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032627 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001382 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-27 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-27 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-27 release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-27 production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001198 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032631 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001383 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific IP-10 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects IP-10 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CXCL10/IP-10 release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific IP-10 production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001308 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071612 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001384 obo:IAO_0000111 "cell culture analyte detection bioassay measuring epitope specific interleukin-3 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A reporter cell line analyte detection bioassay that detects interleukin-3 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-3 release|bioassay" ; a owl:Class ; rdfs:label "cell culture analyte detection bioassay measuring epitope specific interleukin-3 production by T cells" ; rdfs:subClassOf obo:OBI_0000904, obo:OBI_0001406 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000904 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032632 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001385 obo:IAO_0000111 "intracellular cytokine staining assay measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects tumor necrosis factor superfamily cytokine production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TNF release|ICS" ; a owl:Class ; rdfs:label "intracellular cytokine staining assay measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0001400 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071706 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001386 obo:IAO_0000111 "epitope specific monocyte chemotactic protein-1 production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of monocyte chemotactic protein-1 production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific monocyte chemotactic protein-1 production by T cells" ; rdfs:subClassOf obo:GO_0071605, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0071605 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001387 obo:IAO_0000111 "genotyping by array design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that classifies an individual or group of individuals on the basis of alleles, haplotypes, SNPs using microarray technology." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_560 genotyping_design" ; a owl:Class ; rdfs:label "genotyping by array design" ; rdfs:subClassOf obo:OBI_0001444 . obo:OBI_0001388 obo:IAO_0000111 "assay measuring epitope specific interleukin-1 alpha production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interleukin-1 alpha production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-1a release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interleukin-1 alpha production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032610 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001389 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-6 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-6 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-6 release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-6 production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001451 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032635 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001390 obo:IAO_0000111 "assay measuring epitope specific interferon-beta production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interferon-beta production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IFNb release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interferon-beta production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032608 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001391 obo:IAO_0000111 "assay measuring epitope specific interleukin-12 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interleukin-12 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-12 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interleukin-12 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032615 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001392 obo:IAO_0000111 "in vivo assay measuring epitope specific T cell killing" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo cell killing assay that measures the killing of antigen presenting cells (APC) by T cells whose TCR recognizes an epitope presented by the APC." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "cytotoxicity|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring epitope specific T cell killing" ; rdfs:subClassOf obo:OBI_0000883, obo:OBI_0001484, obo:OBI_1110130 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000883 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001913 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] ) ] . obo:OBI_0001393 obo:IAO_0000111 "comparative genomic hybridization by array assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures changes in DNA sequence copy number using a microarray. For example the analysis of LOH in tumor cells vs a non diseased sample or the comparison of clinical isolated of disease causing bacteria." ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000118 "array CGH" ; obo:IAO_0000119 "EFO:0000749" ; a owl:Class ; rdfs:label "comparative genomic hybridization by array assay" ; rdfs:subClassOf obo:OBI_0000435, obo:OBI_0001985, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400148 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400148 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16991 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16991 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_16991 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001305 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000131 ] . obo:OBI_0001394 obo:IAO_0000111 "epitope specific cytotoxic T cell degranulation" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of cytotoxic T cell degranulation resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific cytotoxic T cell degranulation" ; rdfs:subClassOf obo:GO_0043316 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0043316 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001395 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-23 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-23 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-23 release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-23 production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001363 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032627 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001396 obo:IAO_0000111 "stimulus or stress design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which the response of an organism(s) to the stress or stimulus is studied, e.g. osmotic stress, heat shock, radiation exposure, behavioral treatment etc." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_568 stimulus_or_stress_design" ; a owl:Class ; rdfs:label "stimulus or stress design" ; rdfs:subClassOf obo:OBI_0000115, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000268 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0050896 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000931 ] ) ] ] . obo:OBI_0001397 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific granulocyte colony stimulating factor production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects granulocyte colony stimulating factor production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "G-CSF release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific granulocyte colony stimulating factor production by T cells" ; rdfs:subClassOf obo:OBI_0001600, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071611 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001398 obo:IAO_0000111 "protein and DNA interaction identification objective"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A sequence feature identification objective that aims to characterize the interactions between protein and DNA which includes identification of transcription factor binding sites."@en ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "MO_933 binding_site_identification_design"@en ; a owl:Class ; rdfs:label "protein and DNA interaction identification objective"@en ; rdfs:subClassOf obo:OBI_0000113 . obo:OBI_0001399 obo:IAO_0000111 "epitope specific interleukin-22 production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of interleukin-22 production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific interleukin-22 production by T cells" ; rdfs:subClassOf obo:GO_0032626, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032626 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001400 obo:IAO_0000111 "assay measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects tumor necrosis factor superfamily cytokine production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TNF release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071706 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001401 obo:IAO_0000111 "protocol optimization design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design where different protocols or protocol parameters are compared aims to find an optimized protocol" ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_934 optimization_design" ; a owl:Class ; rdfs:label "protocol optimization design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000186 ] . obo:OBI_0001402 obo:IAO_0000111 "promoter activity detection by reporter gene assay measuring epitope specific interleukin-2 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A promoter activity detection by reporter gene assay that detects interleukin-2 production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-2 release|reporter gene assay" ; a owl:Class ; rdfs:label "promoter activity detection by reporter gene assay measuring epitope specific interleukin-2 production by T cells" ; rdfs:subClassOf obo:OBI_0000913, obo:OBI_0001445 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000913 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032623 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001403 obo:IAO_0000111 "ChIP-chip design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design which aims to identify protein binding sites in genomic DNA by a combination of chromatin immunoprecipitation and DNA microarray (chip) assays." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000118 "ChIP-on-chip design" ; obo:IAO_0000119 "MO_933 binding_site_identification_design" ; a owl:Class ; rdfs:label "ChIP-chip design" ; rdfs:subClassOf obo:OBI_0001425, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001398 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0042571 ] ) ] ] . obo:OBI_0001404 obo:IAO_0000111 "genetic characteristics information"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a data item that is about genetic material including polymorphisms, disease alleles, and haplotypes."@en ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "MO_66 IndividualGeneticCharacteristics"@en ; obo:IAO_0000232 """MO definition: The genotype of the individual organism from which the biomaterial was derived. Individual genetic characteristics include polymorphisms, disease alleles, and haplotypes. examples in ArrayExpress wild_type MutaMouse (CD2F1 mice with lambda-gt10LacZ integration) AlfpCre; SNF5 flox/knockout p53 knock out C57Bl/6 gp130lox/lox MLC2vCRE/+ fer-15; fem-1 df/df pat1-114/pat1-114 ade6-M210/ade6-M216 h+/h+ (cells are diploid)"""@en ; a owl:Class ; rdfs:label "genetic characteristics information"@en ; rdfs:subClassOf obo:IAO_0000027, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:SO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000058 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33696 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0100026 ] ) ] ] ] ) ] ] . obo:OBI_0001405 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific macrophage inflammatory protein-1 alpha production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects macrophage inflammatory protein-1 alpha production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL3/MIP-1a release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific macrophage inflammatory protein-1 alpha production by T cells" ; rdfs:subClassOf obo:OBI_0001333, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071608 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001406 obo:IAO_0000111 "assay measuring epitope specific interleukin-3 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interleukin-3 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-3 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interleukin-3 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032632 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001407 obo:IAO_0000111 "assay measuring epitope specific T cell activation" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope dependent biological activity assay that detects T cell activation." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "activation|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific T cell activation" ; rdfs:subClassOf obo:OBI_0002055 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042110 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001408 obo:IAO_0000111 "imprinting design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design where differences in genetic imprinting of maternally- and paternally-inherited chromosomes (e.g., due to in vivo differences in chemical modification and/or chromatin structure) are compared." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_914 imprinting_design" ; a owl:Class ; rdfs:label "imprinting design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000131 ] . obo:OBI_0001409 obo:IAO_0000111 "cell cycle design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that assays events that occur in relation to the cell cycle, which is the period between the formation of a cell, by division of its mother cell and the time when the cell itself divides to form two daughter cells." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_822 cell_cycle_design" ; a owl:Class ; rdfs:label "cell cycle design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000219 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0007049 ] ) ] ] . obo:OBI_0001410 obo:IAO_0000111 "translation profiling design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which surface-bound, translationally competent ribosome complexes are used to generate a translation profile for mRNA, where mRNA may be a single molecular species, or a combination of species, including complex mixtures such as those found in the set of mRNAs isolated from a cell or tissue. One or more components of the surface-bound ribosome complex may be labeled at specific positions to permit analysis of multiple or single molecules for determination of ribosomal conformational changes and translation kinetics. Translation profiles are used as the basis for comparison of an mRNA or set of mRNA species. The translation profile can be used to determine such characteristics as kinetics of initiation, kinetic of elongation, identity of the polypeptide product, and the like. Analysis of translation profiles may be used to determine differential gene expression, optimization of mRNA sequences for expression, screening drug candidates for an effect on translation." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "Group: ArrayExpress production team" ; a owl:Class ; rdfs:label "translation profiling design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000131 ] . obo:OBI_0001411 obo:IAO_0000111 "cell type comparison design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that compares cells of different type, for example different cell lines." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_764 cell_type_comparison_design" ; a owl:Class ; rdfs:label "cell type comparison design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000219 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000000 ] ) ] ] . obo:OBI_0001412 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific RANTES production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects RANTES production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL5/RANTES release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific RANTES production by T cells" ; rdfs:subClassOf obo:OBI_0001232, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071609 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001413 obo:IAO_0000111 "cell culture analyte detection bioassay measuring epitope specific interleukin-6 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A reporter cell line analyte detection bioassay that detects interleukin-6 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-6 release|bioassay" ; a owl:Class ; rdfs:label "cell culture analyte detection bioassay measuring epitope specific interleukin-6 production by T cells" ; rdfs:subClassOf obo:OBI_0000904, obo:OBI_0001451 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000904 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032635 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001414 obo:IAO_0000111 "assay measuring epitope specific interferon-gamma production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interferon-gamma production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IFNg release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interferon-gamma production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032609 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001415 obo:IAO_0000111 "epitope specific interleukin-9 production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of interleukin-9 production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific interleukin-9 production by T cells" ; rdfs:subClassOf obo:GO_0032638, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032638 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001416 obo:IAO_0000111 "assay measuring epitope specific tumor necrosis factor alpha production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay of epitope specific tumor necrosis factor alpha production by T cells that detects tumor necrosis factor production." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TNFa release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific tumor necrosis factor alpha production by T cells" ; rdfs:subClassOf obo:OBI_0001400 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032640 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001417 obo:IAO_0000111 "ChIP-chip by tiling array design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design which aims to identify protein binding sites in genomic DNA by a combination of chromatin immunoprecipitation and tiling microarray (chip) assays." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "Group: ArrayExpress production team" ; a owl:Class ; rdfs:label "ChIP-chip by tiling array design" ; rdfs:subClassOf obo:OBI_0001403 . obo:OBI_0001418 obo:IAO_0000111 "dose response design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that examines the relationship between the size of the administered dose and the extent of the response." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_485 dose_response_design" ; a owl:Class ; rdfs:label "dose response design" ; rdfs:subClassOf obo:OBI_0000951, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000015 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000931 obo:OBI_0000995 ) ] ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000969 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000995 ] ) ] ] ) ] ] . obo:OBI_0001419 obo:IAO_0000111 "ChIP-chip by tiling array assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A ChIP-ChIP assay in which immunoprecipitated chromatin is run on a tiling array that covers stretches of DNA to to detect which elements in those stretches are present in the isolated chromatin" ; obo:IAO_0000117 "ArrayExpress production team" ; obo:IAO_0000119 "EFO:0002762" ; a owl:Class ; rdfs:label "ChIP-chip by tiling array assay" ; rdfs:subClassOf obo:OBI_0001248, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001307 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001307 ] ) ] . obo:OBI_0001420 obo:IAO_0000111 "epitope specific helper T cell enhancement of T cell mediated immune response" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of helper T cell enhancement of T cell mediated immune response resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific helper T cell enhancement of T cell mediated immune response" ; rdfs:subClassOf obo:GO_0035398 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0035398 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001421 obo:IAO_0000111 "epitope specific interferon-beta production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of interferon-beta production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific interferon-beta production by T cells" ; rdfs:subClassOf obo:GO_0032608, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032608 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001422 obo:IAO_0000111 "organism part comparison design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that compares tissues, regions, organs within or between organisms" ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_953 organism_part_comparison_design" ; a owl:Class ; rdfs:label "organism part comparison design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000268 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0000465 ] ) ] ] . obo:OBI_0001423 obo:IAO_0000111 "intracellular material detection measuring epitope specific granzyme B release by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects epitope specific granzyme B release by T cells" ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "granzyme B release|intracellular staining" ; a owl:Class ; rdfs:label "intracellular material detection measuring epitope specific granzyme B release by T cells" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0001436 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0003319 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001424 obo:IAO_0000111 "Miltenyi Biotec" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Karin Breuer" ; obo:IAO_0000119 "WEB:http://www.miltenyibiotec.com/@2011/04/11" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Miltenyi Biotec" . obo:OBI_0001425 obo:IAO_0000111 "protein binding site identification design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that investigates protein binding sites on nucleic acids." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_933 binding_site_identification_design" ; a owl:Class ; rdfs:label "protein binding site identification design" ; rdfs:subClassOf obo:OBI_0500000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001398 ] . obo:OBI_0001426 obo:IAO_0000111 "sex comparison design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that assays differences associated with an organism's sex, gender or mating type." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_575 sex_design" ; a owl:Class ; rdfs:label "sex comparison design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000268 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PATO_0000047 ] ) ] ] . obo:OBI_0001427 obo:IAO_0000111 "transcription profiling by tiling array design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which gene expression on a genome-wide basis is evaluated, without bias toward coding or noncoding regions, using tiling arrays containing oligonucleotides that are either overlapping or spaced at regular intervals." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_507 tiling_path_design" ; a owl:Class ; rdfs:label "transcription profiling by tiling array design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001331 ] . obo:OBI_0001428 obo:IAO_0000111 "AES Chemunex" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Karin Breuer" ; obo:IAO_0000119 "WEB:http://www.aeschemunex.com/@2011/04/11" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "AES Chemunex" . obo:OBI_0001429 obo:IAO_0000111 "cell differentiation design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that assays events associated with cell development or differentiation." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_892 development_or_differentiation_design" ; a owl:Class ; rdfs:label "cell differentiation design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000219 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0048869 ] ) ] ] . obo:OBI_0001430 obo:IAO_0000111 "transcription profiling design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that identifies forms and abundance of transcripts in the genome." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_533 transcript_identification_design" ; a owl:Class ; rdfs:label "transcription profiling design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0001431 obo:IAO_0000111 "Bentley Instruments" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Karin Breuer" ; obo:IAO_0000119 "WEB:http://bentleyinstruments.com/@2011/04/11" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Bentley Instruments" . obo:OBI_0001432 obo:IAO_0000111 "operon identification design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that identifies locations and members of operons in a genome." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_772 operon_identification_design" ; a owl:Class ; rdfs:label "operon identification design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000113 ] . obo:OBI_0001433 obo:IAO_0000111 "radio immuno assay measuring epitope specific interferon-gamma production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A radio immuno assay that detects interferon-gamma production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IFNg release|radio immuno assay (RIA)" ; a owl:Class ; rdfs:label "radio immuno assay measuring epitope specific interferon-gamma production by T cells" ; rdfs:subClassOf obo:OBI_0000910, obo:OBI_0001414 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000910 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032609 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001434 obo:IAO_0000111 "Invitrogen" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Karin Breuer" ; obo:IAO_0000119 "WEB:http://www.invitrogen.com/@2011/04/11" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Invitrogen" . obo:OBI_0001435 obo:IAO_0000111 "DNA methylation profiling by high throughput sequencing design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which the methylation state of DNA is determined and is compared between samples using high throughput sequencing technology." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "GROUP: ArrayExpress production team" ; a owl:Class ; rdfs:label "DNA methylation profiling by high throughput sequencing design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001234 ] . obo:OBI_0001436 obo:IAO_0000111 "assay measuring epitope specific granzyme B release by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytotoxic T cell degranulation assay that detects granzyme B release by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "granzyme B release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific granzyme B release by T cells" ; rdfs:subClassOf obo:OBI_0001269 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0003319 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001437 obo:IAO_0000111 "intracellular cytokine staining assay measuring epitope specific chemokine (C-X-C motif) ligand 9 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects chemokine (C-X-C motif) ligand 9 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CXCL9/MIG release|ICS" ; a owl:Class ; rdfs:label "intracellular cytokine staining assay measuring epitope specific chemokine (C-X-C motif) ligand 9 production by T cells" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0001459 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0035393 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001438 obo:IAO_0000111 "ELISA measuring epitope specific macrophage inflammatory protein-1 gamma production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects macrophage inflammatory protein-1 gamma production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL9/MIP-1g release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific macrophage inflammatory protein-1 gamma production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001456 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071607 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0001439 obo:IAO_0000111 "epitope specific chemokine (C-X-C motif) ligand 9 production by T cells" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A process of chemokine (C-X-C motif) ligand 9 production by T cells resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB (QTT)" ; obo:IAO_0000232 "Date: 2011-04-01; Spreadsheet: All AssayTypes.xls; Worksheet: E specific Template; Mapping: e_specific_mappings.owl" ; a owl:Class ; rdfs:label "epitope specific chemokine (C-X-C motif) ligand 9 production by T cells" ; rdfs:subClassOf obo:GO_0035393, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0035393 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0001440 obo:IAO_0000111 "all pairs design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which all specimens are compared to every other specimen." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "MO_565 all_pairs" ; a owl:Class ; rdfs:label "all pairs design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0001441 obo:IAO_0000111 "proteomic profiling by array design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which proteins in a sample are detected, quantified or otherwise analysed, through an array-based technology." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng, Dan Berrios" ; obo:IAO_0000119 "Group: ArrayExpress production team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/854" ; a owl:Class ; rdfs:label "proteomic profiling by array design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000131 ] . obo:OBI_0001442 obo:IAO_0000111 "q-value" ; obo:IAO_0000112 """PMID: 20483222. Comp Biochem Physiol Part D Genomics Proteomics. 2008 Sep;3(3):234-42. Analysis of Sus scrofa liver proteome and identification of proteins differentially expressed between genders, and conventional and genetically enhanced lines. \"After controlling the false discovery rate (FDR3' on plus strand) that acts as the leader for DNA extension in a PCR reaction. The polymerase starts replication at the 3'-end of the primer, and copies the opposite strand. A primer is characterized by its 'melting temperature' (Tm) and pairs of primers should have similar Tm."@en ; obo:IAO_0000117 "Philippe Rocca-Serra"@en ; obo:IAO_0000118 "5' primer"@en, "forward primer"@en, "sense primer"@en ; obo:IAO_0000119 "adapted from http://www.ncbi.nlm.nih.gov/projects/genome/probe/doc/Glossary.shtml#p"@en ; a owl:Class ; rdfs:label "forward PCR primer"@en ; rdfs:subClassOf obo:CHEBI_16991, obo:OBI_0001879, [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16991 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000086 ] ) ] . obo:OBI_0001947 obo:IAO_0000111 "sequence annotation provider"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A person or organization reporting the feature annotation results from the analysis of a macromolecular sequence." ; obo:IAO_0000117 "PERSON: Jie Zheng, Chris Stoeckert" ; obo:IAO_0000119 "NIAID GSCID-BRC metadata working group" ; obo:OBI_0001886 "annotation provider" ; dc:source "NIAID GSCID-BRC" ; a owl:Class ; rdfs:label "sequence annotation provider"@en ; rdfs:subClassOf obo:BFO_0000040 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:unionOf (obo:NCBITaxon_9606 obo:OBI_0000245 ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0001949 ] ) ] . obo:OBI_0001948 obo:IAO_0000111 "sequence assembly name"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A textual entity that is used to denote a sequence assembly." ; obo:IAO_0000117 "PERSON: Jie Zheng, Chris Stoeckert" ; obo:IAO_0000119 "NIAID GSCID-BRC metadata working group" ; obo:OBI_0001886 "assembly name" ; dc:source "NIAID GSCID-BRC" ; a owl:Class ; rdfs:label "sequence assembly name"@en ; rdfs:subClassOf obo:IAO_0000300 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:IAO_0000300 [ a owl:Restriction ; owl:allValuesFrom obo:SO_0000353 ; owl:onProperty obo:IAO_0000219 ] ) ] . obo:OBI_0001949 obo:IAO_0000111 "sequence annotation reporting role"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A reporting party role that is realized by a person or organization who reports the feature annotation results from the analysis of a macromolecular sequence." ; obo:IAO_0000117 "PERSON: Jie Zheng, Chris Stoeckert" ; obo:IAO_0000119 "NIAID GSCID-BRC metadata working group" ; dc:source "NIAID GSCID-BRC" ; a owl:Class ; rdfs:label "sequence annotation reporting role"@en ; rdfs:subClassOf obo:OBI_0000068 . obo:OBI_0001950 obo:IAO_0000111 "has performer"@en ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "A relation between a planned process and a continuant where the continuant can be a person, organization or device (such as a robot controlled by software workflow management system) that performs the planned process." ; obo:IAO_0000117 "OBI"@en ; obo:IAO_0000119 "OBI" ; a owl:ObjectProperty ; rdfs:comment "The 'has performer' relation covers the need to report on who performed a planned processed. It has to cover processes done by People or Devices (such as a robot controlled by software WF management system)." ; rdfs:domain obo:OBI_0000011 ; rdfs:label "has performer"@en ; rdfs:range [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:unionOf (obo:NCBITaxon_9606 obo:OBI_0000245 obo:OBI_0000968 ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000202 ] ) ] ; rdfs:subPropertyOf obo:RO_0000057 . obo:OBI_0001951 obo:IAO_0000111 "reverse PCR primer"@en ; obo:IAO_0000112 ""@en, "5' end of luciferase, reverse primer (LucNrev CCTTATGCAGTTGCTCTCC)"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A short oligonucleotide complementary to target DNA (5'->3' on minus strand) that acts as the leader for DNA extension in a PCR reaction. The polymerase starts replication at the 3'-end of the primer, and copies the opposite strand. A primer is characterized by its 'melting temperature' (Tm) and pairs of primers should have similar Tm."@en ; obo:IAO_0000117 "Philippe Rocca-Serra"@en ; obo:IAO_0000118 "3' primer"@en, "antisense primer"@en, "reverse primer"@en ; obo:IAO_0000119 "adapted from \"http://www.ncbi.nlm.nih.gov/projects/genome/probe/doc/Glossary.shtml#p\""@en ; a owl:Class ; rdfs:label "reverse PCR primer"@en ; rdfs:subClassOf obo:CHEBI_16991, obo:OBI_0001879, [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16991 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000086 ] ) ] . obo:OBI_0001952 obo:IAO_0000111 "flash freezing"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A freezing process by which material entities are quickly frozen by subjecting them to cryogenic temperatures, or in direct contact with Liquid nitrogen at -320.8F or -196°C." ; obo:IAO_0000117 "Person: Mathias Brochhausen, Jie Zheng" ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Flash_freezing" ; a owl:Class ; rdfs:label "flash freezing"@en ; rdfs:subClassOf obo:OBI_0001953 . obo:OBI_0001953 obo:IAO_0000111 "freezing"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process with the objective to bring some material entity to a temperature below its freezing point." ; obo:IAO_0000117 "Person: Mathias Brochhausen, Jie Zheng" ; obo:IAO_0000119 "Mathias Brochhausen" ; a owl:Class ; rdfs:label "freezing"@en ; rdfs:subClassOf obo:OBI_0000011 . obo:OBI_0001954 obo:IAO_0000111 "ChIP assay" ; obo:IAO_0000112 "PMID: 6379641" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An assay in which portions of chromatin, the ordered and organized complex of DNA and its interaction partners that make up a chormosome, is extracted and purified by immunoprecipitation with antibodies or tags, and subsequently analyzed" ; obo:IAO_0000117 "Bjoern Peters", "Philippe Rocca-Serra" ; obo:IAO_0000118 "chromatin immunoprecipitation assay" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Chromatin_immunoprecipitation" ; a owl:Class ; rdfs:label "ChIP assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000785 ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000785 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_00001975 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0001234 obo:OBI_0001398 ) ] ] ) ] . obo:OBI_0001955 obo:IAO_0000111 "competitive binding reference ligand role" ; obo:IAO_0000112 "The role of a radiolabeled peptide that is known to bind to the MHC molecule HLA-A*02:01 with high affinity when it is used in a competitive binding assay in which another peptide of interest is tested for its ability to outcompete binding of the labeled peptide in a dose dependent fashion." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A positive reference substance role that inheres in a material entity that is known to bind to a target entity, and that is realized in a competitive binding assay that has as specified input the target entity, an evaluant and the positive reference substance, where the binding of the evaluant to the target is measured based on the evaluant's ability to compete with the positive reference substance for binding to the target." ; obo:IAO_0000117 "Bjoern Peters, Randi Vita, James A. Overton" ; obo:IAO_0000119 "Bjoern Peters" ; a owl:Class ; rdfs:label "competitive binding reference ligand role" ; rdfs:subClassOf obo:OBI_0000064 . obo:OBI_0001956 obo:IAO_0000111 "assay using chromatin immunoprecipitation" ; obo:IAO_0000112 "http://www.lifetechnologies.com/uk/en/home/life-science/epigenetics-noncoding-rna-research/chromatin-remodeling/chromatin-immunoprecipitation-chip.html" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An assay that produces data about protein-DNA interaction or DNA epigenetic modification using immunoprecipitation" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000233 "http://sourceforge.net/p/obi/obi-terms/707/" ; a owl:Class ; rdfs:label "assay using chromatin immunoprecipitation" ; rdfs:subClassOf obo:OBI_0001700, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_00001975 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0001234 obo:OBI_0001398 ) ] ] . obo:OBI_0001957 obo:IAO_0000111 "hardware testing design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that aims to compare different types of hardware for performance, reproducibility, accuracy and precision." ; obo:IAO_0000117 "Person: Jie Zheng" ; obo:IAO_0000119 "MO_734 hardware_variation_design" ; a owl:Class ; rdfs:label "hardware testing design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000968 ] ) ] ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0500000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000134 ] ) ] . obo:OBI_0001958 obo:IAO_0000111 "systematic review study design" ; obo:IAO_0000112 "Red blood cell transfusion in patients with traumatic brain injury: a systematic review protocol. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090399/", "The effect of moderate gestational alcohol consumption during pregnancy on speech and language outcomes in children: a systematic review. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892059/" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design for identifying in the literature prior studies of a pre-determined phenomenon or set of related phenomena according to certain criteria, extracting findings from these studies, and summarizing these findings and/or attempting to draw new conclusions from them which were not justified by any of the individual, prior studies. Many systematic reviews also assess the quality of the studies so reviewed." ; obo:IAO_0000117 "PERSON: Bill Hogan" ; a owl:Class ; rdfs:label "systematic review study design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0001959 obo:IAO_0000111 "multiplexed nucleotide library sequencing"@en ; obo:IAO_0000112 "http://www.illumina.com/technology/multiplexing_sequencing_assay.ilmn"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A planned process which consists in running a set of samples as a pool on a sequencing instrument, while retaining the ability to associate individual results to each of the individual input samples through the use of a ligated oligonucleotide (the \"multiplex identifier sequence\"). This oligonucleotide is introduced during the sequence library preparation, and is unique to and specific for all library fragments derived from each sample in a sample pool."@en ; obo:IAO_0000117 "Dan Berrios", "PERSON:Philippe Rocca-Serra"@en ; obo:IAO_0000119 "OBI"@en ; a owl:Class ; rdfs:label "multiplexed nucleotide library sequencing"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001970 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0002602 ] . obo:OBI_0001960 obo:IAO_0000111 "taxonomic diversity assessment by targeted gene survey" ; obo:IAO_0000112 "PMID:20679230", "PMID:25367129" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An assay that dteremines taxonomic and community diversity information by sequencing specific genomic regions used as marker of identity or diversity." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "environmental gene survey", "targeted gene survey", "targeted gene survey DNA barcoding" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "taxonomic diversity assessment by targeted gene survey" ; rdfs:subClassOf obo:OBI_0600047 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600047 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000181 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001969 ] ) ] . obo:OBI_0001961 obo:IAO_0000111 "PCR program"@en ; obo:IAO_0000112 "https://www.neb.com/protocols/1/01/01/taq-dna-polymerase-with-standard-taq-buffer-m0273"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "a PCR program is a plan specification which is executed during a polymerase chain reaction (PCR) by a thermocycler instrument that will iterate through the changes in temperature and duration of each of the annealing, denaturation, elongation steps for as many times as specified by the program."@en ; obo:IAO_0000117 "PERSON:Philippe Rocca-Serra"@en ; obo:IAO_0000119 "OBI"@en ; a owl:Class ; rdfs:label "PCR program"@en ; rdfs:subClassOf obo:IAO_0000104 . obo:OBI_0001962 obo:IAO_0000111 "target gene specification"@en ; obo:IAO_0000112 """http://www.ncbi.nlm.nih.gov/pubmed/25367129 \"performing a profiling of microbial phylogenetic composition using sequencing of 16S rRNA gene (used as target gene)"""@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "is a directive information specifying a coding genomic region which is the focus of a planned process such as an assay, for instance in a environmental gene survey"@en ; obo:IAO_0000117 "PERSON:Philippe Rocca-Serra"@en ; obo:IAO_0000119 "PRS for OBI"@en ; obo:OBI_0001847 "target gene"@en ; a owl:Class ; rdfs:label "target gene specification"@en ; rdfs:subClassOf obo:IAO_0000033 . obo:OBI_0001963 obo:IAO_0000111 "target subfragment specification"@en ; obo:IAO_0000112 """http://www.ncbi.nlm.nih.gov/pubmed/23335919 \"performing a profiling of microbial phylogenetic composition using massively-parallel pyrotag sequencing targeting the V9 hypervariable region (used as target subfragment) of the 18S ribosomal RNA (rRNA) gene (used as target gene)"""@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "is a directive information specifying a genomic region, possibly located in a coding genomic region, which is the focus of a planned process such as an assay, for instance in a environmental gene survey"@en ; obo:IAO_0000117 "PERSON:Philippe Rocca-Serra"@en ; obo:IAO_0000119 "PRS for OBI"@en ; obo:OBI_0001847 "target subfragment"@en ; a owl:Class ; rdfs:label "target subfragment specification"@en ; rdfs:subClassOf obo:IAO_0000033 . obo:OBI_0001964 obo:IAO_0000111 "decision-theoretic analysis objective" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An objective specification which what includes a description of two or more alternative actions to take in a particular situation and a metric that enables comparisons of the two actions. The objective specified is achieved in a planned process which includes a data transformation, the output of which is an identification of the 'best' choice according to the metric." ; obo:IAO_0000116 "The best action to take is typically defined as the one that maximizes expected utility." ; obo:IAO_0000117 "PERSON: Bill Hogan" ; obo:IAO_0000118 "decision analysis objective" ; obo:IAO_0000119 "PERSON: Bill Hogan" ; a owl:Class ; rdfs:label "decision-theoretic analysis objective" ; rdfs:subClassOf obo:IAO_0000005 . obo:OBI_0001965 obo:IAO_0000111 "decision analysis study design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a study design that has a decision analysis objective specification as part" ; obo:IAO_0000117 "PERSON: Bill Hogan" ; obo:IAO_0000119 "PERSON: Bill Hogan" ; a owl:Class ; rdfs:label "decision analysis study design" ; rdfs:subClassOf obo:OBI_0500000 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0500000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001964 ] ) ] . obo:OBI_0001966 obo:IAO_0000111 "sequence library data demultiplexing"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "is a data transformation which uses sequence alignment and 'multiplex identifier sequence' information to separate all reads belonging to a given single sample following the sequencing of a multiplexed library"@en ; obo:IAO_0000117 "PERSON: Philippe Rocca-Serra"@en ; obo:IAO_0000119 "PRS for OBI"@en ; a owl:Class ; rdfs:label "sequence library data demultiplexing"@en ; rdfs:subClassOf obo:OBI_0200187, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200081 ] . obo:OBI_0001967 obo:IAO_0000111 "multiplexing sequence identifier"@en ; obo:IAO_0000112 "We designed primers specifically to amplify protease and reverse transcriptase from Brazilian HIV subtypes and developed a multiplexing scheme using multiplex identifier tags to minimize cost while providing more robust data than traditional genotyping techniques. in http://www.ncbi.nlm.nih.gov/pubmed/22574170"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A multiplexing sequence identifier is a nucleic acid sequence which is used in a ligation step of library preparation process to allow pooling of samples while maintaining ability to identify individual source material and creation of a multiplexed library"@en ; obo:IAO_0000117 "PERSON:Philippe Rocca-Serra"@en ; obo:IAO_0000119 "OBI"@en ; a owl:Class ; rdfs:label "multiplexing sequence identifier"@en ; rdfs:subClassOf obo:CHEBI_16991, [ a owl:Restriction ; owl:onProperty obo:OBI_0000295 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000711 obo:OBI_0001959 ) ] ] . obo:OBI_0001968 obo:IAO_0000111 "operational taxonomic unit matrix"@en ; obo:IAO_0000112 "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1610290/"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "Operational Taxonomic Unit matrix is a data item, organized as a table, where organismal taxonomic units, computed by sequence analysis and genetic distance calculation, are counted in a set of biological or environmental samples. The table is used to appraise biodiversity of a population or community of living organism."@en ; obo:IAO_0000117 "PERSON:Philippe Rocca-Serra"@en ; obo:IAO_0000119 "PRS for OBI"@en ; a owl:Class ; rdfs:label "operational taxonomic unit matrix"@en ; rdfs:subClassOf obo:IAO_0000027, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:BFO_0000040 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0200000 ] . obo:OBI_0001969 obo:IAO_0000111 "biodiversity assessment objective"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "biodiversity assessment objective is an objective of a planned process aimed at producing data item whose interpretation should provide insight about variety of biological species found in a biological sample at macroscopic or microscopic level"@en ; obo:IAO_0000117 "PERSON:Philippe Rocca-Serra"@en ; obo:IAO_0000119 "PRS for OBI"@en ; a owl:Class ; rdfs:label "biodiversity assessment objective"@en ; rdfs:subClassOf obo:OBI_0000015 . obo:OBI_0001970 obo:IAO_0000111 "multiplexed sequencing library"@en ; obo:IAO_0000112 """http://www.ncbi.nlm.nih.gov/pubmed/24997861 Nat Methods. 2014 Aug;11(8):834-40. doi: 10.1038/nmeth.3022. Epub 2014 Jul 6. Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries."""@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "a multiplexed library is a material entity which is the output of a library preparation process that uses a ligation step to attach a unique multiplexing sequence identifier to a specific sample, then mixes several such tagged samples prior to the library amplification process proper. A multiplexed library allows the sequencing of several samples in one sequencing run."@en ; obo:IAO_0000117 "PERSON:Philippe Rocca-Serra"@en ; obo:IAO_0000118 "DNA-barcoded sequencing library"@en ; obo:IAO_0000119 "PRS for OBI"@en ; a owl:Class ; rdfs:label "multiplexed sequencing library"@en ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001967 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000711 obo:OBI_0001959 ) ] ] . obo:OBI_0001971 obo:IAO_0000111 "Ion 316 Chip v2" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An ion semiconductor chip manufactured by Life Technologies which detects polymerase-driven base incorporation to translate into digital form. The 316 chip is compatible with the Ion Torrent PGM and has a run time of: 3.0 hours for 200 bp reads with an output of 30-50 Mb, 4.9 hours for 400 bp reads with an output of 60 Mb-1 Gb." ; obo:IAO_0000116 "Issue Tracker #774 https://sourceforge.net/p/obi/obi-terms/774/" ; obo:IAO_0000117 "PERSON: Sagar Jain" ; obo:IAO_0000118 "Ion 316 Chip", "Ion PGM 316 Chip", "Ion PGM 316 Chip v2" ; obo:IAO_0000119 "http://www.lifetechnologies.com/us/en/home/life-science/sequencing/next-generation-sequencing/ion-torrent-next-generation-sequencing-workflow/ion-torrent-next-generation-sequencing-run-sequence/ion-pgm-ion-proton-system-chips.html" ; a owl:Class ; rdfs:label "Ion 316 Chip v2" ; rdfs:subClassOf obo:OBI_0001973 . obo:OBI_0001972 obo:IAO_0000111 "Ion 318 Chip v2" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An ion semiconductor chip manufactured by Life Technologies which detects polymerase-driven base incorporation to translate into digital form. The 318 chip is compatible with the Ion Torrent PGM and has a run time of: 4.4 hours for 200 bp reads with an output of 60 Mb-1 Gb, 7.3 hours for 400 bp reads with an output of 1.2 Gb-2 Gb." ; obo:IAO_0000116 "Issue Tracker #775 https://sourceforge.net/p/obi/obi-terms/775/" ; obo:IAO_0000117 "PERSON: Sagar Jain" ; obo:IAO_0000118 "Ion 318 Chip", "Ion PGM 318 Chip", "Ion PGM 318 Chip v2" ; obo:IAO_0000119 "http://www.lifetechnologies.com/us/en/home/life-science/sequencing/next-generation-sequencing/ion-torrent-next-generation-sequencing-workflow/ion-torrent-next-generation-sequencing-run-sequence/ion-pgm-ion-proton-system-chips.html" ; a owl:Class ; rdfs:label "Ion 318 Chip v2" ; rdfs:subClassOf obo:OBI_0001973 . obo:OBI_0001973 obo:IAO_0000111 "ion semiconductor chip" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An ion detector that is organized as an electronic circuit whose components, such as transistors and resistors, are etched or deposited on a single slice of semiconductor material to produce a chip. The specific chip detects ion charge induced when an ion passes by or hits a surface." ; obo:IAO_0000116 "Issue Tracker: #776 https://sourceforge.net/p/obi/obi-terms/776/" ; obo:IAO_0000117 "PERSON: Sagar Jain" ; obo:IAO_0000118 "ion chip", "ion integrated circuit", "ion semiconductor" ; obo:IAO_0000119 "http://www.thefreedictionary.com/Semiconductor+chip" ; a owl:Class ; rdfs:label "ion semiconductor chip" ; rdfs:subClassOf obo:OBI_0000364 . obo:OBI_0001974 obo:IAO_0000111 "Ion 314 Chip v2" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An ion semiconductor chip manufactured by Life Technologies which detects polymerase-driven base incorporation to translate into digital form. The 314 chip is compatible with the Ion Torrent PGM and has a run time of: 2.3 hours for 200 bp reads with an output of 30-50 Mb, 3.7 hours for 400 bp reads with an output of 60-100 Mb." ; obo:IAO_0000116 "Issue Tracker #766 https://sourceforge.net/p/obi/obi-terms/766/" ; obo:IAO_0000117 "PERSON: Sagar Jain" ; obo:IAO_0000118 "Ion 314 Chip", "Ion PGM 314 Chip", "Ion PGM 314 Chip v2" ; obo:IAO_0000119 "http://www.lifetechnologies.com/us/en/home/life-science/sequencing/next-generation-sequencing/ion-torrent-next-generation-sequencing-workflow/ion-torrent-next-generation-sequencing-run-sequence/ion-pgm-ion-proton-system-chips.html" ; a owl:Class ; rdfs:label "Ion 314 Chip v2" ; rdfs:subClassOf obo:OBI_0001973 . obo:OBI_0001976 obo:IAO_0000111 "hydrogen/deuterium exchange footprinting assay" ; obo:IAO_0000112 "Performing deuterium exchange on a protein by itself and in the presence of a binding partner, degrading the protein into peptide segments and identifying where deuterium exchange occurred by detecting the peptides in Mass Spectrometry. Peptides that have a modified deuteration pattern when the protein was bound to a partner are expected to be part of the binding interface." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A footprinting assay that uses a chemical reaction whereby a covalently bonded hydrogen atom is replaced by a deuterium atom, or vice versa in order to gather information about the solvent accessibility of parts of a molecule and thus its tertiary structure." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "hydrogen/deuterium exchange footprinting assay" ; rdfs:subClassOf obo:OBI_0002162, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29237 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29237 ] ) ] . obo:OBI_0001977 obo:IAO_0000111 "cytometry assay" ; obo:IAO_0000112 "An intracellular material detection by flow cytometry assay measuring peforin inside a culture of T cells." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that counts and/or measures characteristics of cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "cytometry assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:CL_0000000 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] ) ] . obo:OBI_0001978 obo:IAO_0000111 "immunoblot assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that detects specific molecules in an input material by separating it using gel electrophoresis, transfering the separated molecules to a membrane, and staining them with_ antibodies specific to the analyte molecules." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "immunoblot assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001121 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001121 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_23367 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_23367 ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0600053 ] . obo:OBI_0001979 obo:IAO_0000111 "fluorescence quenching binding assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A binding assay in which the proximity of two entities is monitored by measuring a fluorescent signal of one of the entities that gets reduced if the two entities are cliose to each other." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "fluorescence quenching binding assay" ; rdfs:subClassOf obo:OBI_0001499, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001501 obo:OBI_0003368 ) ] ] . obo:OBI_0001980 obo:IAO_0000111 "in vivo intervention experiment" ; obo:IAO_0000112 "Comparing the level of allergy symptoms in humans before and post allergy immunotherapy. Testing if injection of a chemical compound into mice will lead to decreased survival." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay in which the effect of a targeted process (the intervention) on an organism is tested." ; obo:IAO_0000116 "The intervention in an experiment should be modeled accordingly to the intevention carried out in a human cllinical trial, which is currently modeled as 'study intervention'. This touches the boundaries of study vs. assay." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "in vivo intervention experiment" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0100026 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0001981 obo:IAO_0000111 "disease exacerbation in vivo intervention experiment" ; obo:IAO_0000112 "Injecting a set of mice with a peptide and measuring symtoms to determine if their disease course was more severe than the disease course of a set of mice that were not injected with the same peptide." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo intervention experiment that tests the ability of the intervention to increase the severity of a disease in the host." ; obo:IAO_0000116 "Should have data about disease severity as readout; could just use disease for now" ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "disease exacerbation in vivo intervention experiment" ; rdfs:subClassOf obo:OBI_0001980 . obo:OBI_0001982 obo:IAO_0000111 "protection from challenge in vivo intervention experiment" ; obo:IAO_0000112 "Injecting a set of mice with a peptide and measuring symtoms to determine if their disease course was less severe than the disease course of a set of mice that were not injected with the same peptide." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo intervention experiment that tests the ability of the intervention to prevent occurrence of a disease in a host." ; obo:IAO_0000116 "should have challenge as intervention" ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "protection from challenge in vivo intervention experiment" ; rdfs:subClassOf obo:OBI_0001980 . obo:OBI_0001983 obo:IAO_0000111 "tolerance induction intervention experiment" ; obo:IAO_0000112 "Injecting a set of mice with a Der p 2 peptide and measuring the IL-2 response of T cells from those mice when exposed to the Der p 2 protein in vitro to determine if those T cells made less IL-2 than cells taken from mice which were not injected with the same Der p 2 peptide." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo intervention experiment that tests the ability of the intervention to decrease an immune response." ; obo:IAO_0000116 "should have tolerance induction as intervention" ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "tolerance induction intervention experiment" ; rdfs:subClassOf obo:OBI_0001980 . obo:OBI_0001984 obo:IAO_0000111 "treatment intervention experiment" ; obo:IAO_0000112 "Testing if administering oral histamine-blockers will reduce the number of emergency room visits in severely asthmatic individuals." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo intervention experiment in which the ability of the intervention to reduce or cure the effects of a disease are tested." ; obo:IAO_0000116 "should have treatment as intervention" ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "treatment intervention experiment" ; rdfs:subClassOf obo:OBI_0001980 . obo:OBI_0001985 obo:IAO_0000111 "microarray assay" ; obo:IAO_0000112 "Measuring if sera from an influenza A virus immunizedmouse binds to Hemagglutinin protein that is immobilized on a microarray." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay where binding of the analyte to immobilized matrix is measured." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "microarray assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400147 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400147 ] ) ] ) ] . obo:OBI_0001986 obo:IAO_0000111 "immunohistochemistry" ; obo:IAO_0000112 "Staining a brain tissue sample from an Alzheimer's disease patient with antibodies to amyloid beta to identify amyloid plaques." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An immunostaining assay to detect and potentially localize antigens within the cells of a tissue section." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "immunohistochemistry" ; rdfs:subClassOf obo:OBI_0001632 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001632 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001479 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001479 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002743 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:BFO_0000040 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:BFO_0000040 ] ) ] ) ] . obo:OBI_0001987 obo:IAO_0000111 "assay measuring the association constant [KA] of a MHC:ligand complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A MHC binding constant determination assay measuring equilibrium association constant (KA)." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "association constant KA|binding assay|1/M" ; a owl:Class ; rdfs:label "assay measuring the association constant [KA] of a MHC:ligand complex" ; rdfs:subClassOf obo:OBI_0001553 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001548 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001503 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000285 ; owl:onProperty obo:IAO_0000039 ] ] ) ] . obo:OBI_0001988 obo:IAO_0000111 "assay measuring the dissociation constant [KD] of a MHC:ligand complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A MHC binding constant determination assay measuring equilibrium dissociation constant (KD)." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "dissociation constant KD|binding assay|nM" ; a owl:Class ; rdfs:label "assay measuring the dissociation constant [KD] of a MHC:ligand complex" ; rdfs:subClassOf obo:OBI_0001553 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001536 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001503 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000065 ; owl:onProperty obo:IAO_0000039 ] ] ) ] . obo:OBI_0001989 obo:IAO_0000111 "radioactivity detection assay measuring equilibrium dissociation constant [KD] to determine competitive binding of a purified-MHC:ligand complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A radioactivity detection assay that measures equilibrium dissociation constant (KD) to detect the loss of binding of a known reference ligand to purified-MHC due to competition by the ligand under investigation." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "dissociation constant KD|purified MHC/direct/radioactivity|nM" ; a owl:Class ; rdfs:label "radioactivity detection assay measuring equilibrium dissociation constant [KD] to determine competitive binding of a purified-MHC:ligand complex" ; rdfs:subClassOf obo:OBI_0001491, obo:OBI_0001988 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001491 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0001955 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001485 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042611 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001536 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001503 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000065 ; owl:onProperty obo:IAO_0000039 ] ] ) ] . obo:OBI_0001990 obo:IAO_0000111 "assay measuring the half life of a MHC:ligand complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A MHC binding constant determination assay measuring half life of binding." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "half life|binding assay|min" ; a owl:Class ; rdfs:label "assay measuring the half life of a MHC:ligand complex" ; rdfs:subClassOf obo:OBI_0001553 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001583 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001503 ] ] ) ] . obo:OBI_0001991 obo:IAO_0000111 "assay measuring the half maximal effective concentration [EC50] of a MHC:ligand complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A MHC binding constant determination assay measuring half maximal effective concentration (EC50)." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "half maximal effective concentration (EC50)|binding assay|nM" ; a owl:Class ; rdfs:label "assay measuring the half maximal effective concentration [EC50] of a MHC:ligand complex" ; rdfs:subClassOf obo:OBI_0003145 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0003143 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001503 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000065 ; owl:onProperty obo:IAO_0000039 ] ] ) ] . obo:OBI_0001992 obo:IAO_0000111 "assay measuring the half maximal inhibitory concentration [IC50] of a MHC:ligand complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A MHC binding constant determination assay measuring half maximal inhibitory concentration (IC50)." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "half maximal inhibitory concentration (IC50)|binding assay|nM" ; a owl:Class ; rdfs:label "assay measuring the half maximal inhibitory concentration [IC50] of a MHC:ligand complex" ; rdfs:subClassOf obo:OBI_0003145 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0003144 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001503 ] ] ) ] . obo:OBI_0001993 obo:IAO_0000111 "assay measuring the off rate measurement [koff] of a MHC:ligand complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A MHC binding constant determination assay measuring binding off rate measurement data item (koff)." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "off rate|binding assay|1/s" ; a owl:Class ; rdfs:label "assay measuring the off rate measurement [koff] of a MHC:ligand complex" ; rdfs:subClassOf obo:OBI_0001553 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001603 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001503 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000106 ; owl:onProperty obo:IAO_0000039 ] ] ) ] . obo:OBI_0001994 obo:IAO_0000111 "assay measuring the MHC ligand binding on rate [kon] of a MHC:ligand complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A MHC binding constant determination assay measuring binding on rate (kon)." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "on rate|binding assay|nM^-1s^-1" ; a owl:Class ; rdfs:label "assay measuring the MHC ligand binding on rate [kon] of a MHC:ligand complex" ; rdfs:subClassOf obo:OBI_0001553 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001605 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001503 ] ] ) ] . obo:OBI_0001995 obo:IAO_0000111 "chromatography assay measuring the association constant [KA] of a B cell epitope:antibody complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analytical chromatography assay that measures the association constant [KA] of an antigen binding with an antibody." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "association constant KA|chromatography|1/nM" ; a owl:Class ; rdfs:label "chromatography assay measuring the association constant [KA] of a B cell epitope:antibody complex" ; rdfs:subClassOf obo:OBI_0001630, obo:OBI_0001719 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001630 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001548 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001702 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000284 ; owl:onProperty obo:IAO_0000039 ] ] ) ] . obo:OBI_0001996 obo:IAO_0000111 "chromatography assay measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analytical chromatography assay that measures the dissociation constant [KD] of an antigen binding with an antibody." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "dissociation constant KD|chromatography|nM" ; a owl:Class ; rdfs:label "chromatography assay measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ; rdfs:subClassOf obo:OBI_0001630, obo:OBI_0001708 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001630 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001536 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001702 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000065 ; owl:onProperty obo:IAO_0000039 ] ] ) ] . obo:OBI_0001997 obo:IAO_0000111 "hydrogen/deuterium exchange footprinting assay measuring binding of a B cell epitope:antibody complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A hydrogen/deuterium exchange footprinting assay that detects the binding of an antigen with an antibody." ; obo:IAO_0000117 "PERSON:Randi Vita, James Overton, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "qualitative binding|hydrogen/deuterium exchange footprinting assay" ; a owl:Class ; rdfs:label "hydrogen/deuterium exchange footprinting assay measuring binding of a B cell epitope:antibody complex" ; rdfs:subClassOf obo:OBI_0001976, obo:OBI_0002449 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001976 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0003141 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001702 ] ] ) ] . obo:OBI_0001998 obo:IAO_0000111 "immunohistochemistry assay measuring binding of a B cell epitope:antibody complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A immunohistochemistry assay that detects the binding of an antigen with an antibody." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "qualitative binding|immunohistochemistry" ; a owl:Class ; rdfs:label "immunohistochemistry assay measuring binding of a B cell epitope:antibody complex" ; rdfs:subClassOf obo:OBI_0001652, obo:OBI_0001986 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001986 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0003141 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001702 ] ] ) ] . obo:OBI_0001999 obo:IAO_0000111 "3D molecular structure determination assay of a T cell epitope:MHC:TCR complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A 3D structure determination of bound molecular complex assay that characterizes the 3-dimensional structure of a T cell epitope:MHC:TCR complex." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "3D structure|any method" ; a owl:Class ; rdfs:label "3D molecular structure determination assay of a T cell epitope:MHC:TCR complex" ; rdfs:subClassOf obo:OBI_0001145, obo:OBI_0003128 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001155 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0003120 ] ] ) ] . obo:OBI_0002000 obo:IAO_0000111 "Genome Analyzer IIx" ; obo:IAO_0000112 "Gravina, Michael T., Jenny H. Lin, and Stuart S. Levine. \"Lane-by-lane sequencing using Illumina's Genome Analyzer II.\" BioTechniques 54.5 (2013): 265-269. PMID: 23662897" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An Illumina Genome Analyzer II which is manufactured by the Illumina corporation. It supports sequencing of single, long or short insert paired end clone libraries relying on sequencing by synthesis technology. The Genome Analyzer IIx is the most widely adopted next-generation sequencing platform and proven and published across the broadest range of research applications." ; obo:IAO_0000117 "PERSON: Venkat Malladi, Chris Stoeckert, Jie Zheng, Alan Ruttenberg" ; obo:IAO_0000118 "Illumina GA IIx", "Illumina Genome Analyzer IIx" ; obo:IAO_0000119 "ENCODE group" ; a owl:Class ; rdfs:label "Genome Analyzer IIx" ; rdfs:subClassOf obo:OBI_0000703 . obo:OBI_0002001 obo:IAO_0000111 "Illumina HiSeq 2000" ; obo:IAO_0000112 "Wang J, Qi J, Zhao H, He S, Zhang Y, Wei S, Zhao F. Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease. Sci Rep. 2013 May;3:1843. PMID:23673380" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencer which is manufactured by the Illumina corporation, with two flow cells and a throughput of up to 55 Gb per day. Built upon sequencing by synthesis technology, the machine is optimized for generation of data for multiple samples in a single run." ; obo:IAO_0000117 "PERSON: Venkat Malladi, Chris Stoeckert, Jie Zheng" ; obo:IAO_0000118 "HiSeq 2000" ; obo:IAO_0000119 "http://res.illumina.com/documents/products/datasheets/datasheet_hiseq_systems.pdf" ; a owl:Class ; rdfs:label "Illumina HiSeq 2000" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000759 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002002 obo:IAO_0000111 "Illumina HiSeq 2500" ; obo:IAO_0000112 "Spaethling, Jennifer M., and James H. Eberwine. \"Single-cell transcriptomics for drug target discovery.\" Current opinion in pharmacology (2013). pmid:23725882" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencer which is manufactured by the Illumina corporation, with two flow cells and a throughput of up to 160 Gb per day. Built upon sequencing by synthesis technology, the machine is optimized for generation of data for batching multiple samples or rapid results on a few samples." ; obo:IAO_0000117 "PERSON: Venkat Malladi, Chris Stoeckert, Jie Zheng, Alan Ruttenberg" ; obo:IAO_0000118 "HiSeq 2500" ; obo:IAO_0000119 "http://res.illumina.com/documents/products/datasheets/datasheet_hiseq2500.pdf" ; a owl:Class ; rdfs:label "Illumina HiSeq 2500" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000759 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002003 obo:IAO_0000111 "MiSeq" ; obo:IAO_0000112 "Rutvisuttinunt W, Chinnawirotpisan P, Simasathien S, Shrestha SK, Yoon IK, Klungthong C, Fernandez S. Simultaneous and complete genome sequencing of influenza A and B with high coverage by Illumina MiSeq Platform. J Virol Methods. 2013 Nov;193(2):394-404. [PMID:23856301]" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencer which is manufactured by the Illumina corporation. Built upon sequencing by synthesis technology, the machine provides an end-to-end solution (cluster generation, amplification, sequencing, and data analysis) in a single machine." ; obo:IAO_0000117 "PERSON: Venkat Malladi, Chris Stoeckert, Jie Zheng" ; obo:IAO_0000118 "Illumina MiSeq" ; obo:IAO_0000119 "http://res.illumina.com/documents/products/datasheets/datasheet_miseq.pdf" ; a owl:Class ; rdfs:label "MiSeq" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000759 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002004 obo:IAO_0000111 "Methylation 450K BeadChip" ; obo:IAO_0000112 "Naumov, Vladimir A., et al. \"Genome-scale analysis of DNA methylation in colorectal cancer using Infinium HumanMethylation450 BeadChips.\" Epigenetics 8.9 (2013): 0-1. PMID: 23867710" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A methylation BeadChip which is manufactured by the Illumina corporation. Built upon BeadChip tehcnology, the array interrogates ~ 485,000 methylation sites per sample at single-nucleotide resolution." ; obo:IAO_0000117 "PERSON: Venkat Malladi, Chris Stoeckert, Jie Zheng, Alan Ruttenberg" ; obo:IAO_0000118 "Illumina Infinium Human Methylation 450K BeadChip" ; obo:IAO_0000119 "http://www.illumina.com/products/methylation_450_beadchip_kits.ilmn" ; a owl:Class ; rdfs:label "Methylation 450K BeadChip" ; rdfs:subClassOf obo:OBI_0001870 . obo:OBI_0002005 obo:IAO_0000111 "Methylation 27K BeadChip" ; obo:IAO_0000112 "Polidoro, Silvia, et al. \"Effects of bisphosphonate treatment on DNA methylation in osteonecrosis of the jaw.\" Mutation Research/Genetic Toxicology and Environmental Mutagenesis 757.2 (2013): 104-113. PMID: 23892139" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A methylation BeadChip which is manufactured by the Illumina corporation. Built upon BeadChip tehcnology, the array interrogates ~ 27,000 CpG sites per sample at single-nucleotide resolution." ; obo:IAO_0000117 "PERSON: Venkat Malladi, Chris Stoeckert, Jie Zheng, Alan Ruttenberg" ; obo:IAO_0000118 "Illumina Infinium Human Methylation 27K BeadChip" ; obo:IAO_0000119 "http://res.illumina.com/documents/products/datasheets/datasheet_dna_methylation_analysis.pdf" ; a owl:Class ; rdfs:label "Methylation 27K BeadChip" ; rdfs:subClassOf obo:OBI_0001870 . obo:OBI_0002006 obo:IAO_0000111 "1M-Duo Infinium HD BeadChip" ; obo:IAO_0000112 "Edwards, Todd L., et al. \"Genome-Wide Association Study Confirms SNPs in SNCA and the MAPT Region as Common Risk Factors for Parkinson Disease.\" Annals of human genetics 74.2 (2010): 97-109. PMID: 20070850" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A BeadChip which is manufactured by the Illumina corporation. Built upon BeadChip tehcnology, the array integrates ~ 1 million markers per sample for genotyping, and copy number variation (CNV) and Cytogenetic analysis." ; obo:IAO_0000117 "PERSON: Venkat Malladi, Chris Stoeckert, Jie Zheng, Alan Ruttenberg" ; obo:IAO_0000118 "Illumina Human 1M-Duo Infinium HD BeadChip" ; obo:IAO_0000119 "http://www.illumina.com/technology/infinium_hd_assay.ilmn" ; a owl:Class ; rdfs:label "1M-Duo Infinium HD BeadChip" ; rdfs:subClassOf obo:OBI_0001869 . obo:OBI_0002007 obo:IAO_0000111 "SOLiD 3 Plus System" ; obo:IAO_0000112 "Vissers, Lisenka ELM, et al. \"A de novo paradigm for mental retardation.\" Nature genetics 42.12 (2010): 1109-1112. PMID:21076407" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencer which is manufacted by the Applied Biosystems corporation. Built upon SOLiD sequencing technology, the machine generates greater than 1 billion mappable reads per run." ; obo:IAO_0000117 "PERSON: Venkat Malladi, Chris Stoeckert, Jie Zheng, Alan Ruttenberg" ; obo:IAO_0000118 "Applied Biosystems SOLiD 3 Plus System" ; obo:IAO_0000119 "http://www3.appliedbiosystems.com/cms/groups/mcb_marketing/documents/generaldocuments/cms_072050.pdf" ; a owl:Class ; rdfs:label "SOLiD 3 Plus System" ; rdfs:subClassOf obo:OBI_0000696, [ a owl:Restriction ; owl:hasValue obo:OBI_0000776 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002008 obo:IAO_0000111 "Mouse 385K Whole Genome CGH Tiling Array" ; obo:IAO_0000112 "Miller, Becky Akiko. Detection and biological assessment of genome structural variation in Plasmodium falciparum. Diss. University of Notre Dame, 2012. http://etd.nd.edu/ETD-db/theses/available/etd-04182012-114744/" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A tiling array which is manufactured by the Nimblegen corporation. Built to analyze DNA sequence copy number by comparative genomic hybridization for mouse DNA against 385,000 features." ; obo:IAO_0000117 "PERSON: Venkat Malladi, Chris Stoeckert, Jie Zheng, Alan Ruttenberg" ; obo:IAO_0000118 "Nimblegen Mouse 385K Whole Genome CGH Tiling Array" ; obo:IAO_0000119 "http://www.nimblegen.com/downloads/support/05434483001_NG_CGHLOH_UGuide_v9p1.pdf" ; a owl:Class ; rdfs:label "Mouse 385K Whole Genome CGH Tiling Array" ; rdfs:subClassOf obo:OBI_0001307, [ a owl:Restriction ; owl:hasValue obo:OBI_0001855 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002009 obo:IAO_0000111 "Mouse 3x720K Whole Genome CGH Tiling Array" ; obo:IAO_0000112 "Wartman, Lukas D., et al. \"Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression.\" The Journal of clinical investigation 121.4 (2011): 1445. PMID:21436584" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A tiling array which is manufactured by the Nimblegen corporation. Built to analyze DNA sequence copy number by comparative genomic hybridization for mouse DNA against 3x720,000 features." ; obo:IAO_0000117 "PERSON: Venkat Malladi, Chris Stoeckert, Jie Zheng, Alan Ruttenberg" ; obo:IAO_0000118 "Nimblegen Mouse 3x720K Whole Genome CGH Tiling Array" ; obo:IAO_0000119 "http://www.nimblegen.com/downloads/support/05434483001_NG_CGHLOH_UGuide_v9p1.pdf" ; a owl:Class ; rdfs:label "Mouse 3x720K Whole Genome CGH Tiling Array" ; rdfs:subClassOf obo:OBI_0001307, [ a owl:Restriction ; owl:hasValue obo:OBI_0001855 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002010 obo:IAO_0000111 "Human 3x720K Whole Genome CGH Tiling Array" ; obo:IAO_0000112 "Deletion in Xp22.11: PTCHD1 is a candidate gene for X-linked intellectual disability with or without autism PMID:21091464" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A tiling array which is manufactured by the Nimblegen corporation. Built to analyze DNA sequence copy number by comparative genomic hybridization for human DNA against 3x720,000 features." ; obo:IAO_0000117 "PERSON: Venkat Malladi, Chris Stoeckert, Jie Zheng, Alan Ruttenberg" ; obo:IAO_0000118 "Nimblegen Human 3x720K Whole Genome CGH Tiling Array" ; obo:IAO_0000119 "http://www.nimblegen.com/downloads/support/05434483001_NG_CGHLOH_UGuide_v9p1.pdf" ; a owl:Class ; rdfs:label "Human 3x720K Whole Genome CGH Tiling Array" ; rdfs:subClassOf obo:OBI_0001307, [ a owl:Restriction ; owl:hasValue obo:OBI_0001855 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002011 obo:IAO_0000111 "Human 2.1M Whole-Genome CGH Tiling Array v2.0" ; obo:IAO_0000112 "Filges, Isabel, et al. \"Reduced expression by SETBP1 haploinsufficiency causes developmental and expressive language delay indicating a phenotype distinct from Schinzel–Giedion syndrome.\" Journal of medical genetics 48.2 (2011): 117-122. PMID:21037274" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A tiling array which is manufactured by the Nimblegen corporation. Built to analyze DNA sequence copy number by comparative genomic hybridization for human DNA against 2.1 million features." ; obo:IAO_0000117 "PERSON: Venkat Malladi, Chris Stoeckert, Jie Zheng, Alan Ruttenberg" ; obo:IAO_0000118 "Nimblegen Human 2.1M Whole-Genome CGH Tiling Array v2.0" ; obo:IAO_0000119 "http://www.nimblegen.com/downloads/support/05434483001_NG_CGHLOH_UGuide_v9p1.pdf" ; a owl:Class ; rdfs:label "Human 2.1M Whole-Genome CGH Tiling Array v2.0" ; rdfs:subClassOf obo:OBI_0001307, [ a owl:Restriction ; owl:hasValue obo:OBI_0001855 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002012 obo:IAO_0000111 "PacBio RS II" ; obo:IAO_0000112 "Spaethling, Jennifer M., and James H. Eberwine. \"Single-cell transcriptomics for drug target discovery.\" Current opinion in pharmacology (2013). pmid:23725882" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencer which is manufactured by the Pacific Biosciences corporation. Built upon single molecule real-time sequencing technology, the machine is optimized for generation with long reads and high consensus accuracy." ; obo:IAO_0000117 "PERSON: Venkat Malladi, Chris Stoeckert, Jie Zheng, Alan Ruttenberg" ; obo:IAO_0000118 "Pacific Biosciences RS II" ; obo:IAO_0000119 "http://www.pacificbiosciences.com/products/" ; a owl:Class ; rdfs:label "PacBio RS II" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0001856 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002013 obo:IAO_0000111 "nCounter Human miRNA Expression array" ; obo:IAO_0000112 "Kolbert, Christopher P., et al. \"Multi-platform analysis of microRNA expression measurements in RNA from fresh frozen and FFPE tissues.\" PloS one 8.1 (2013): e52517. PMID:23382819" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A human array which is manufacutred by NanoString Technologies. Built upon color-coded molecular barcodes technology, the array profiles miRNA with increased specificity and sensitivty than microarrays." ; obo:IAO_0000117 "PERSON: Venkat Malladi, Chris Stoeckert, Jie Zheng, Alan Ruttenberg. Mark A. Miller removed \"V2\" per https://github.com/obi-ontology/obi/issues/831 on 20180511." ; obo:IAO_0000119 "https://www.nanostring.com/products/mirna-assays/mirna-panels" ; a owl:Class ; rdfs:label "nCounter Human miRNA Expression array" ; rdfs:subClassOf obo:OBI_0001865, [ a owl:Restriction ; owl:hasValue obo:OBI_0001860 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002014 obo:IAO_0000111 "DNA methylation profiling by ChIP-chip assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An epigenetic modification assay that identifies sites of DNA methylation using ChIP-chip technologies." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng" ; obo:IAO_0000118 "DNA methylation ChIP-chip" ; obo:IAO_0000119 "Penn group" ; a owl:Class ; rdfs:label "DNA methylation profiling by ChIP-chip assay" ; rdfs:subClassOf obo:OBI_0001248, obo:OBI_0002020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400148 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400148 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000785 ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000785 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_00001975 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001248 obo:OBI_0003368 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001234 ] . obo:OBI_0002015 obo:IAO_0000111 "transcription profiling by MPSS assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A transcription profiling assay that uses Massive Parallel Signature Sequencing (MPSS)." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng" ; obo:IAO_0000118 "expression MPSS" ; obo:IAO_0000119 "url:http://en.wikipedia.org/wiki/Massively_parallel_signature_sequencing" ; a owl:Class ; rdfs:label "transcription profiling by MPSS assay" ; rdfs:subClassOf obo:OBI_0000424, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_1000207 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_1000207 ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000711 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000626 obo:OBI_0003368 ) ] ] . obo:OBI_0002016 obo:IAO_0000111 "histone modification identification by ChIP-chip assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An epigenetic modification assay that identifies regions containing specific histones and their modifications using ChIP-chip techniques." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng" ; obo:IAO_0000118 "histone modification ChIP-chip" ; obo:IAO_0000119 "Penn group" ; a owl:Class ; rdfs:label "histone modification identification by ChIP-chip assay" ; rdfs:subClassOf obo:OBI_0001248, obo:OBI_0002020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400148 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400148 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000785 ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000785 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_00001975 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001248 obo:OBI_0003368 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000030 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0016570 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001234 ] . obo:OBI_0002017 obo:IAO_0000111 "histone modification identification by ChIP-Seq assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An epigenetic modification assay that identifies regions containing specific histones and their modifications using ChIP-Seq techniques." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng" ; obo:IAO_0000118 "histone modification ChIP-Seq" ; obo:IAO_0000119 "Penn group" ; a owl:Class ; rdfs:label "histone modification identification by ChIP-Seq assay" ; rdfs:subClassOf obo:OBI_0000716, obo:OBI_0002020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400103 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000785 ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000785 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_00001975 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000716 obo:OBI_0003368 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001573 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0016570 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001234 ] . obo:OBI_0002018 obo:IAO_0000111 "transcription factor binding site identification by ChIP-chip assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A transcription factor binding site assay that utilizes ChIP-chip technology." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng" ; obo:IAO_0000118 "TF Binding ChIP-chip" ; obo:IAO_0000119 "Penn group" ; a owl:Class ; rdfs:label "transcription factor binding site identification by ChIP-chip assay" ; rdfs:subClassOf obo:OBI_0000291, obo:OBI_0001248, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400148 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400148 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000785 ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000785 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_00001975 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001248 obo:OBI_0003368 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000030 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:SO_0000235 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001398 ] . obo:OBI_0002019 obo:IAO_0000111 "transcription factor binding site identification by ChIP-Seq assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A transcription factor binding site assay that utilizes ChIP-seq technology." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng" ; obo:IAO_0000118 "TF Binding ChIP-Seq" ; obo:IAO_0000119 "Penn group" ; a owl:Class ; rdfs:label "transcription factor binding site identification by ChIP-Seq assay" ; rdfs:subClassOf obo:OBI_0000291, obo:OBI_0000716, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400103 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000785 ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000785 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_00001975 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000716 obo:OBI_0003368 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001573 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:SO_0000235 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001398 ] . obo:OBI_0002020 obo:IAO_0000111 "epigenetic modification assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that identifies epigenetic modifications including histone modifications, open chromatin, and DNA methylation." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng" ; obo:IAO_0000119 "Penn group" ; a owl:Class ; rdfs:label "epigenetic modification assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001234 ] ) ] . obo:OBI_0002021 obo:IAO_0000111 "NextSeq 500" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencer which is a desktop sequencer ideal for smaller-scale studies manufactured by the Illumina corporation. It supports sequencing of single, long or short insert paired end clone libraries relying on sequencing by synthesis technology." ; obo:IAO_0000117 "Person: Venkat Malladi, Chris Stoeckert, Jie Zheng" ; obo:IAO_0000118 "Illumina NextSeq 500" ; obo:IAO_0000119 "http://systems.illumina.com/systems/nextseq-sequencer.html" ; a owl:Class ; rdfs:label "NextSeq 500" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000759 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002022 obo:IAO_0000111 "Illumina HiSeq 1000" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencer which is manufactured by the Illumina corporation, with a single flow cell and a throughput of up to 35 Gb per day. It supports sequencing of single, long or short insert paired end clone libraries relying on sequencing by synthesis technology." ; obo:IAO_0000117 "Person: Venkat Malladi, Chris Stoeckert, Jie Zheng" ; obo:IAO_0000118 "HiSeq 1000" ; obo:IAO_0000119 "http://res.illumina.com/documents/products/datasheets/datasheet_hiseq_systems.pdf" ; a owl:Class ; rdfs:label "Illumina HiSeq 1000" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000759 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002023 obo:IAO_0000111 "Human Genome U133 Plus 2.0 tiling array" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A tiling array which is a comprehensive whole human genome expression array manufactured by the Affymetrix corporation. Built to analyze DNA sequence copy number by comparative genomic hybridization for human DNA against 47,000 transcripts and variants." ; obo:IAO_0000117 "Person: Venkat Malladi, Chris Stoeckert, Jie Zheng" ; obo:IAO_0000118 "Affymetrix HT Human Genome U133 Plus 2 Array Plate Set", "HG-U133 Plus 2", "HG-U133 Plus 2 array" ; obo:IAO_0000119 "http://www.affymetrix.com/estore/esearch/search.jsp?pd=131455&N=4294967292" ; a owl:Class ; rdfs:label "Human Genome U133 Plus 2.0 tiling array" ; rdfs:subClassOf obo:OBI_0001307, [ a owl:Restriction ; owl:hasValue obo:OBI_0000462 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002024 obo:IAO_0000111 "SOLiD 4 System" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An AB SOLid System which is manufacted by the Applied Biosystems corporation. Built upon SOLiD sequencing technology, the machine generates greater than 1 billion mappable reads per run." ; obo:IAO_0000117 "Person: Venkat Malladi, Chris Stoeckert, Jie Zheng" ; obo:IAO_0000118 "Applied Biosystems SOLiD 4 System", "SOLiD 4" ; obo:IAO_0000119 "http://www.appliedbiosystems.com/absite/us/en/home/applications-technologies/solid-next-generation-sequencing/next-generation-systems/solid-4-system.html?CID=FL-091411_solid4" ; a owl:Class ; rdfs:label "SOLiD 4 System" ; rdfs:subClassOf obo:OBI_0000696, [ a owl:Restriction ; owl:hasValue obo:OBI_0000776 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002025 obo:IAO_0000111 "Human Exon 1.0 ST tilling array" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A tiling microarray which is manufactured by the Affymetrix corporation. Built to analyze 3' DNA sequence copy number by comparative genomic hybridization for human DNA against 28,000 genes. It can be used for gene expression and alternative splicing assay" ; obo:IAO_0000117 "Person: Venkat Malladi, Chris Stoeckert, Jie Zheng" ; obo:IAO_0000118 "Affymetrix Human Exon 1.0 St Array", "Human Exon 1.0", "Human Exon 1.0 ST Array" ; obo:IAO_0000119 "http://www.affymetrix.com/catalog/131453/AFFY/Human+Gene+ST+Arrays#1_1" ; a owl:Class ; rdfs:label "Human Exon 1.0 ST tilling array" ; rdfs:subClassOf obo:OBI_0001307, [ a owl:Restriction ; owl:hasValue obo:OBI_0000462 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002026 obo:IAO_0000111 "Human Genome U133 tiling array" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A tiling array which is manufactured by the Affymetrix corporation. Built to analyze DNA sequence copy number by comparative genomic hybridization for human DNA against 39,000 transcripts and variants." ; obo:IAO_0000117 "Person: Venkat Malladi, Chris Stoeckert, Jie Zheng" ; obo:IAO_0000118 "Affymetrix HT Human Genome U133 Array Plate Set", "HG-U133", "HG-U133 array" ; obo:IAO_0000119 "http://www.affymetrix.com/estore/esearch/search.jsp?pd=131441&N=4294967292" ; a owl:Class ; rdfs:label "Human Genome U133 tiling array" ; rdfs:subClassOf obo:OBI_0001307, [ a owl:Restriction ; owl:hasValue obo:OBI_0000462 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002027 obo:IAO_0000111 "Genome Analyzer IIe" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An Illumina Genome Analyzer II which is manufactured by the Illumina corporation. It supports sequencing of single, long or short insert paired end clone libraries relying on sequencing by synthesis technology. The Genome Analyzer IIe makes industry-leading next-generation sequencing technology accessible to more laboratories." ; obo:IAO_0000117 "Person: Venkat Malladi, Chris Stoeckert, Jie Zheng" ; obo:IAO_0000118 "Illumina GA IIe", "Illumina Genome Analyzer IIe" ; obo:IAO_0000119 "http://res.illumina.com/documents/products/datasheets/datasheet_genome_analyzer_iie.pdf" ; a owl:Class ; rdfs:label "Genome Analyzer IIe" ; rdfs:subClassOf obo:OBI_0000703 . obo:OBI_0002028 obo:IAO_0000111 "SAGE ditag library preparation"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A library preparation in which tags identifiying transcripts are created, ligated to form ditags, amplified, concatemerized and ligated into a vector to create a library." ; obo:IAO_0000116 "Related tracker:https://sourceforge.net/p/obi/obi-terms/720/" ; obo:IAO_0000117 "Person:Chris Stoeckert" ; obo:IAO_0000119 "PMID:15905473" ; a owl:Class ; rdfs:label "SAGE ditag library preparation"@en ; rdfs:subClassOf obo:OBI_0000711 . obo:OBI_0002029 obo:IAO_0000111 "serial analysis of gene expression assay" ; obo:IAO_0000112 "PMID:15905473" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A transcription profiling assay that quantifies RNA through creating short signature tags of the messages and ligating them into a larger molecule than was sequenced." ; obo:IAO_0000117 "Chris Stoeckert", "Janos Demeter", "Jie Zheng" ; obo:IAO_0000118 "SAGE" ; obo:IAO_0000119 "PMID:7570003" ; obo:IAO_0000233 "https://sourceforge.net/p/obi/obi-terms/720/" ; a owl:Class ; rdfs:label "serial analysis of gene expression assay" ; rdfs:subClassOf obo:OBI_0000424, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400103 ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0002028 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0003368 obo:OBI_0600047 ) ] ] . obo:OBI_0002030 obo:IAO_0000111 "genotyping by tiling array assay" ; obo:IAO_0000112 "PMID:19521816" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A genotyping by array assay that uses tiling array technology." ; obo:IAO_0000117 "Chris Stoeckert", "Janos Demeter", "Jie Zheng" ; obo:IAO_0000118 "DNA sequence variation detection by tiling array" ; obo:IAO_0000119 "PMID:19521816" ; obo:IAO_0000233 "https://sourceforge.net/p/obi/obi-terms/720/" ; a owl:Class ; rdfs:label "genotyping by tiling array assay" ; rdfs:subClassOf obo:OBI_0001274, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001307 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001307 ] ) ] . obo:OBI_0002031 obo:IAO_0000111 "genotyping by SNP array assay" ; obo:IAO_0000112 "PMID:20080586" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A genotyping by array assay that uses SNP array technology." ; obo:IAO_0000117 "Chris Stoeckert", "Janos Demeter", "Jie Zheng" ; obo:IAO_0000118 "DNA sequence variation detection by snp array" ; obo:IAO_0000119 "PMID:20393561" ; obo:IAO_0000233 "https://sourceforge.net/p/obi/obi-terms/720/" ; a owl:Class ; rdfs:label "genotyping by SNP array assay" ; rdfs:subClassOf obo:OBI_0001274, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001204 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001204 ] ) ] . obo:OBI_0002032 obo:IAO_0000111 "parallel analysis of RNA structure assay" ; obo:IAO_0000112 "pmid:20811459" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A single-nucleotide-resolution nucleic acid structure mapping assay that performs simultaneous in vitro profiling of the secondary structure of thousands of RNA species at single nucleotide resolution using enzymatic probing based on deep sequencing fragments of RNAs that were treated with structure-specific enzymes" ; obo:IAO_0000117 "Chris Stoeckert", "Janos Demeter" ; obo:IAO_0000118 "PARS" ; obo:IAO_0000119 "PMID:20811459" ; obo:IAO_0000233 "https://sourceforge.net/p/obi/obi-terms/725/" ; a owl:Class ; rdfs:label "parallel analysis of RNA structure assay" ; rdfs:subClassOf obo:OBI_0001014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000880 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000880 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000427 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000427 ] ) ] . obo:OBI_0002033 obo:IAO_0000111 "translation-associated transcript leader sequencing assay" ; obo:IAO_0000112 "pmid:23580730" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An RNA-seq assay that combines TL-seq with polysome fractionation" ; obo:IAO_0000117 "Chris Stoeckert", "Janos Demeter" ; obo:IAO_0000118 "TATL-seq" ; obo:IAO_0000119 "PMID:23580730" ; obo:IAO_0000233 "https://sourceforge.net/p/obi/obi-terms/725/" ; a owl:Class ; rdfs:label "translation-associated transcript leader sequencing assay" ; rdfs:subClassOf obo:OBI_0001271 . obo:OBI_0002034 obo:IAO_0000111 "transcript leader sequencing assay" ; obo:IAO_0000112 "pmid:23580730" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An RNA-seq assay that combines enzymatic capture of m(7)G-capped mRNA 5' ends with high-throughput sequencing." ; obo:IAO_0000117 "Chris Stoeckert", "Janos Demeter" ; obo:IAO_0000118 "TL-seq" ; obo:IAO_0000119 "PMID:23580730" ; obo:IAO_0000233 "https://sourceforge.net/p/obi/obi-terms/725/" ; a owl:Class ; rdfs:label "transcript leader sequencing assay" ; rdfs:subClassOf obo:OBI_0001271 . obo:OBI_0002035 obo:IAO_0000111 "peptide mass fingerprinting assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A mass spectrometry assay that measures the absolute mass of the cleaved peptides derived from an unknown protein of interest. These masses are then compared to values for known protein sequences to identify the unknown protein." ; obo:IAO_0000117 "Chris Stoeckert", "Janos Demeter" ; obo:IAO_0000118 "PMF", "protein fingerprinting" ; obo:IAO_0000119 "ERO:0001668", "url:http://en.wikipedia.org/wiki/Peptide_mass_fingerprinting" ; obo:IAO_0000233 "https://sourceforge.net/p/obi/obi-terms/725/" ; a owl:Class ; rdfs:label "peptide mass fingerprinting assay" ; rdfs:subClassOf obo:OBI_0000470 . obo:OBI_0002036 obo:IAO_0000111 "array based nucleic acid structure mapping assay" ; obo:IAO_0000112 "pmid:23580730" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay which aims to provide information about the in vivo organization/structure of nucleic acids using chemical or enzymatic probes using a microarray." ; obo:IAO_0000117 "Chris Stoeckert", "Janos Demeter" ; obo:IAO_0000119 "OBI:0000870" ; obo:IAO_0000233 "https://sourceforge.net/p/obi/obi-terms/725/" ; a owl:Class ; rdfs:label "array based nucleic acid structure mapping assay" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0002037 obo:IAO_0000111 "micrococcal nuclease digestion followed by tiling array assay" ; obo:IAO_0000112 "pmid:17873876" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An array based nucleic acid structure mapping assay that identifies nucleosome positions genome wide, by detection of regions protected by nucleosomes from digestion by micrococal nuclease using tiling array assays" ; obo:IAO_0000117 "Chris Stoeckert", "Janos Demeter" ; obo:IAO_0000233 "https://sourceforge.net/p/obi/obi-terms/725/" ; a owl:Class ; rdfs:label "micrococcal nuclease digestion followed by tiling array assay" ; rdfs:subClassOf obo:OBI_0002036 . obo:OBI_0002038 obo:IAO_0000111 "ribosomal profiling by sequencing assay" ; obo:IAO_0000112 "Aspden et al., (August 2014). \"Extensive translation of small open reading frames revealed by poly-ribo-seq.\" eLIFE 2014;3:e03528" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A RNA-seq assay that sequences only mRNA protected by the ribosome during translation." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng", "Venkat Malladi" ; obo:IAO_0000118 "Ribo-seq", "Ribo-seq assay", "ribosomal profiling" ; obo:IAO_0000119 "PMID:24468696" ; a owl:Class ; rdfs:label "ribosomal profiling by sequencing assay" ; rdfs:subClassOf obo:OBI_0001271 . obo:OBI_0002039 obo:IAO_0000111 "assay for transposase-accessible chromatin using sequencing" ; obo:IAO_0000112 "Kasinathan et al., (February 2014). \"High-resolution mapping of transcription factor binding sites on natitve chromatin.\" Nat Methods 11(2):203-9. doi: 10.1038/nmeth.2766." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay to capture the location of open chromatin, DNA-binding proteins, individual nucleosomes and chromatin compaction at nucleotide resolution by Tn5 transposase insertion." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng", "Venkat Malladi" ; obo:IAO_0000118 "ATAC-seq", "ATAC-seq assay" ; obo:IAO_0000119 "PMID:24097267" ; a owl:Class ; rdfs:label "assay for transposase-accessible chromatin using sequencing" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0002040 obo:IAO_0000111 "chromatin isolation by RNA purification sequencing assay" ; obo:IAO_0000112 "Csorba et al., (November 2014). \"Antisense COOLAIR mediates the coordinated switching of chromatin states at FLC during vernalization.\" Proc Natl Acad Sci 111(45):16160-5. doi: 10.1073/pnas.1419030111." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acids with complementary probes assay that measures regions of the genome which are bound by a specific RNA (or a by a ribonucleoprotein containing the RNA of interest) using high-throughput sequencing." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng", "Venkat Malladi" ; obo:IAO_0000118 "ChIRP-seq", "ChIRP-seq assay", "Chromatin Isolation by RNA purification" ; obo:IAO_0000119 "PMID:21963238" ; a owl:Class ; rdfs:label "chromatin isolation by RNA purification sequencing assay" ; rdfs:subClassOf obo:OBI_0000874, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000626 obo:OBI_0003368 ) ] ] . obo:OBI_0002041 obo:IAO_0000111 "self-transcribing active regulatory region sequencing assay" ; obo:IAO_0000112 "Bohla et al., (September 2014). \"A functional insulator screen identifies NURF and dREAM components to be required for enhancer-blocking.\" PLoS One 9(9):e107765. doi: 10.1371/journal.pone.0107765." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An RNA-seq assay that identifies the sequences that act as transcriptional enhancers in a direct, quantitative, and genome-wide manner from sheared genomic DNA." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng", "Venkat Malladi" ; obo:IAO_0000118 "STARR-seq", "STARR-seq assay", "self-transcribing active regulatory region sequencing" ; obo:IAO_0000119 "PMID:23328393" ; a owl:Class ; rdfs:label "self-transcribing active regulatory region sequencing assay" ; rdfs:subClassOf obo:OBI_0001271 . obo:OBI_0002042 obo:IAO_0000111 "carbon-copy chromosome conformation capture assay followed by sequencing assay" ; obo:IAO_0000112 "Fudenberg et al., (November 2014). \"High order chromatin architecture shapes the landscape of chromosomal alterations in cancer.\" Nat Biotechol 29(12):1109-13. doi: 10.1038/nbt.2049." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A carbon-copy chromosome conformation capture assay to analyze the organization of chromosomes in an unbiased, genome-wide manner using high throughput sequening following carbon-copy chromosome conformation capture." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng", "Venkat Malladi" ; obo:IAO_0000118 "Carbon-copy chromosome conformation capture assay followed by sequencing", "HiC", "HiC assay" ; obo:IAO_0000119 "PMID:19815776" ; a owl:Class ; rdfs:label "carbon-copy chromosome conformation capture assay followed by sequencing assay" ; rdfs:subClassOf obo:OBI_0001919 . obo:OBI_0002043 obo:IAO_0000111 "individual-nucleotide resolution cross-linking and immunoprecipitation sequencing assay" ; obo:IAO_0000112 "Protein-RNA interactions: new genomic technologies and perspectives. Nature Reviews Genetics 13 (2): 77-83. doi:10.1038/nrg3141" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cross-linking immunoprecipitation high-throughput sequencing assay that identifies protein-RNA interactions using UV light to covalently bind proteins and RNA molecules, allowing for a very stringent purification of the linked protein-RNA complexes." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng", "Venkat Malladi" ; obo:IAO_0000118 "iCLIP", "iCLIP assay", "individual-nucleotide resolution cross-linking and immunoprecipitation" ; obo:IAO_0000119 "doi:10.1016/j.ymeth.2013.10.011" ; a owl:Class ; rdfs:label "individual-nucleotide resolution cross-linking and immunoprecipitation sequencing assay" ; rdfs:subClassOf obo:OBI_0001858 . obo:OBI_0002044 obo:IAO_0000111 "RNA Bind-n-Seq assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An RNA-seq assay that comprehensively characterizes sequence and structural specificity of RNA binding proteins (RBPs)." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng", "Venkat Malladi" ; obo:IAO_0000118 "RBNS", "RNA Bind-n-Seq", "RNBS assay" ; obo:IAO_0000119 "doi: 10.1016/j.molcel.2014.04.016" ; a owl:Class ; rdfs:label "RNA Bind-n-Seq assay" ; rdfs:subClassOf obo:OBI_0001271 . obo:OBI_0002045 obo:IAO_0000111 "polyA-site sequencing assay" ; obo:IAO_0000112 "Wu et al., (July 2014). \"Genome-wide determination of poly(A) sites in Medicago truncatula: evolutionary conservation of alternative poly(A) site choice. BMC Genomics. 2014 Jul 21;15:615. doi: 10.1186/1471-2164-15-615." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A RNA-seq assay that quantitatively profiles RNA polyadenylation at the transcriptome level." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng", "Venkat Malladi" ; obo:IAO_0000118 "PAS-seq", "PAS-seq assay", "Poly(A)-site sequencing", "poly(A)-site sequencing assay" ; obo:IAO_0000119 "doi: 10.1261/rna.2581711" ; a owl:Class ; rdfs:label "polyA-site sequencing assay" ; rdfs:subClassOf obo:OBI_0001271 . obo:OBI_0002046 obo:IAO_0000111 "surface plasmon resonance sensor chip" ; obo:IAO_0000112 "ProteOn GLC Sensor Chip #176-5011" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A device that is used as a binding surface for ligand during a surface plasmon resonance assay, consisting of a glass plate to which a metal film is attached" ; obo:IAO_0000117 "Anna Maria Masci" ; obo:IAO_0000118 "SPR sensor chip", "biosensor chip", "sensor chip" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "surface plasmon resonance sensor chip" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0001136 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000399 ] . obo:OBI_0002047 obo:IAO_0000111 "enzyme-linked antibody" ; obo:IAO_0000112 "Goat anti-Mouse IgG-HRP (horse radish peroxidase) is an antibody linked to the enzyme horseradish peroxidase (HRP) that catalyzes the conversion of chromogenic substrates into colored products producing light when acting on chemiluminescent substrates (ECL)." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A processed material that is comprised of an antibody that is covalently linked to an enzyme through bioconjugation. The enzyme can be used as a detection method when the enzyme's reaction produces a detectable signal, for example a color change when the substrate is added." ; obo:IAO_0000117 "Bjoern Peters, Randi Vita, James A. Overton" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "enzyme-linked antibody" ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042571 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000427 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600038 ] . obo:OBI_0002048 obo:IAO_0000111 "Illumina HiSeq 3000" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencer manufactured by Illumina corporation, with a single flow cell and a throughput of more than 200 Gb per day." ; obo:IAO_0000117 "PERSON: Sagar Jain, Richard Scheuermann" ; obo:IAO_0000118 "HiSeq 3000" ; obo:IAO_0000119 "http://www.illumina.com/systems/hiseq-3000-4000.html" ; a owl:Class ; rdfs:label "Illumina HiSeq 3000" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000759 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002049 obo:IAO_0000111 "Illumina HiSeq 4000" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencer manufactured by Illumina corporation, with two flow cell and a throughput of more than 400 Gb per day." ; obo:IAO_0000117 "PERSON: Sagar Jain, Richard Scheuermann" ; obo:IAO_0000118 "HiSeq 4000" ; obo:IAO_0000119 "http://www.illumina.com/systems/hiseq-3000-4000.html" ; a owl:Class ; rdfs:label "Illumina HiSeq 4000" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000759 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002050 obo:IAO_0000111 "3D molecular structure determination assay of a MHC:ligand complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A 3D structure determination of bound molecular complex assay that characterizes the 3-dimensional structure of a MHC:ligand complex." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "3D structure|any method" ; a owl:Class ; rdfs:label "3D molecular structure determination assay of a MHC:ligand complex" ; rdfs:subClassOf obo:OBI_0001145, obo:OBI_0002075 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001155 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0003121 ] ] ) ] . obo:OBI_0002051 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific protection from infectious challenge based on pathogen burden" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring B cell epitope specific protection from pathogen challenge using pathogen burden." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "pathogen burden after challenge|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific protection from infectious challenge based on pathogen burden" ; rdfs:subClassOf obo:OBI_0001186, obo:OBI_0003465 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001186 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000712 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003414 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] ) ] . obo:OBI_0002052 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific protection after tumor burden challenge" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring B cell epitope specific protection from tumor challenge using tumor burden." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "tumor burden after challenge|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific protection after tumor burden challenge" ; rdfs:subClassOf obo:OBI_0003458, obo:OBI_0003466 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003458 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003414 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003455 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] ) ] . obo:OBI_0002053 obo:IAO_0000111 "microarray assay measuring binding of a B cell epitope:antibody complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A microarray assay that detects the binding of an antigen with an antibody." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "qualitative binding|microarray" ; a owl:Class ; rdfs:label "microarray assay measuring binding of a B cell epitope:antibody complex" ; rdfs:subClassOf obo:OBI_0001703, obo:OBI_0001985 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001985 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0003141 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001702 ] ] ) ] . obo:OBI_0002054 obo:IAO_0000111 "NMR assay measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A B cell epitope equilibrium dissociation constant (KD) determination assay that uses a nuclear magnetic resonance assay." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "dissociation constant KD|nuclear magnetic resonance (NMR)|nM" ; a owl:Class ; rdfs:label "NMR assay measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ; rdfs:subClassOf obo:OBI_0001708 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001708 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000182 obo:OBI_0003368 ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001536 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001702 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000065 ; owl:onProperty obo:IAO_0000039 ] ] ) ] . obo:OBI_0002055 obo:IAO_0000111 "assay measuring biological activity resulting from T cell epitope:MHC:TCR binding" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope recognition assay that measures the immune response process resulting from the binding of a T cell receptor to epitope or the recongition of the epitope." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "biological activity|any method" ; a owl:Class ; rdfs:label "assay measuring biological activity resulting from T cell epitope:MHC:TCR binding" ; rdfs:subClassOf obo:OBI_0003128 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] ) ] . obo:OBI_0002056 obo:IAO_0000111 "assay measuring epitope specific chemokine (C-C motif) ligand 17 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects production of chemokine (C-C motif) ligand 17 production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL17/TARC release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific chemokine (C-C motif) ligand 17 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0044809 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002057 obo:IAO_0000111 "assay measuring epitope specific macrophage migration inhibitory factor (MIF) production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects macrophage migration inhibitory factor (MIF) production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "MIF release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific macrophage migration inhibitory factor (MIF) production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0044807 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002058 obo:IAO_0000111 "assay measuring epitope specific oncostatin M production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects oncostatin M production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "oncostatin M release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific oncostatin M production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0044808 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002059 obo:IAO_0000111 "assay measuring a binding constant of a T cell epitope:MHC:TCR complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope recognition assay that quantitavely characterizes the binding of a TCR with a ligand by determining a binding constant." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "binding constant|binding assay" ; a owl:Class ; rdfs:label "assay measuring a binding constant of a T cell epitope:MHC:TCR complex" ; rdfs:subClassOf obo:OBI_0003147 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001144 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_1110057 ] ] ) ] . obo:OBI_0002060 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific chemokine (C-C motif) ligand 17 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects chemokine (C-C motif) ligand 17 production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL17/TARC release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific chemokine (C-C motif) ligand 17 production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0002056 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0044809 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002061 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific chemokine (C-C motif) ligand 22 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects chemokine (C-C motif) ligand 22 production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL22/MDC release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific chemokine (C-C motif) ligand 22 production by T cells" ; rdfs:subClassOf obo:OBI_0001777, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071924 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002062 obo:IAO_0000111 "in vitro assay measuring epitope specific T cell killing" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vitro cell killing assay that measures the killing of antigen presenting cells (APC) by T cells whose TCR recognizes an epitope presented by the APC." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "cytotoxicity|in vitro assay" ; a owl:Class ; rdfs:label "in vitro assay measuring epitope specific T cell killing" ; rdfs:subClassOf obo:OBI_0000903, obo:OBI_1110130 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000903 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001913 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom obo:OBI_0001876 ] ] ] ) ] . obo:OBI_0002063 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific granzyme A release by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects epitope specific granzyme A release by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "granzyme A release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific granzyme A release by T cells" ; rdfs:subClassOf obo:OBI_0001809, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0003318 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002064 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific granzyme A release by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acids with complementary probes assay that detects epitope specific granzyme A release by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "granzyme A release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific granzyme A release by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001809 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0003318 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002065 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific granzyme B release by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects epitope specific granzyme B release by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "granzyme B release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific granzyme B release by T cells" ; rdfs:subClassOf obo:OBI_0001436, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0003319 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002066 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific granzyme B release by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acids with complementary probes assay that detects epitope specific granzyme B release by T cells" ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "granzyme B release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific granzyme B release by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0001436 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0003319 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002067 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific macrophage migration inhibitory factor (MIF) production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects macrophage migration inhibitory factor (MIF) production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "MIF release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific macrophage migration inhibitory factor (MIF) production by T cells" ; rdfs:subClassOf obo:OBI_0002057, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0044807 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002068 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific oncostatin M production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects oncostatin M production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "oncostatin M release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific oncostatin M production by T cells" ; rdfs:subClassOf obo:OBI_0002058, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0044808 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002069 obo:IAO_0000111 "ELISPOT assay measuring epitope specific perforin release by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunospot assay that detects epitope specific perforin release by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "perforin release|ELISPOT" ; a owl:Class ; rdfs:label "ELISPOT assay measuring epitope specific perforin release by T cells" ; rdfs:subClassOf obo:OBI_0001497, obo:OBI_0600031 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600031 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0003317 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002070 obo:IAO_0000111 "in vivo assay measuring epitope specific proliferation of T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific proliferation assay that is performed in vivo." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "proliferation|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring epitope specific proliferation of T cells" ; rdfs:subClassOf obo:OBI_0001484, obo:OBI_1110131 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042098 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] ) ] . obo:OBI_0002071 obo:IAO_0000111 "in vitro assay measuring epitope specific proliferation of T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific proliferation assay that is performed on cells in vitro." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "proliferation|in vitro assay" ; a owl:Class ; rdfs:label "in vitro assay measuring epitope specific proliferation of T cells" ; rdfs:subClassOf obo:OBI_1110131 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042098 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom obo:OBI_0001876 ] ] ] ) ] . obo:OBI_0002072 obo:IAO_0000111 "assay measuring qualitative binding of a MHC:ligand complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that detects the binding of a MHC molecule with a ligand, and produces a qualitative measurement of the binding as an output." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "qualitative binding|binding assay" ; a owl:Class ; rdfs:label "assay measuring qualitative binding of a MHC:ligand complex" ; rdfs:subClassOf obo:OBI_1110126 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0003141 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001503 ] ] ) ] . obo:OBI_0002073 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific protection from challenge" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An efficacy of T cell epitope intervention experiment that uses a epitope protection experiment." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "protection from challenge|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific protection from challenge" ; rdfs:subClassOf obo:OBI_0001184, obo:OBI_0001484 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001184 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] ) ] . obo:OBI_0002074 obo:IAO_0000111 "assay measuring T cell epitope specific suppression in vitro" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "T cell epitope dependent biological activity assay that detects suppression of an in vitro response." ; obo:IAO_0000117 "PERSON:Randi Vita, James Overton, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "suppression|in vitro assay" ; a owl:Class ; rdfs:label "assay measuring T cell epitope specific suppression in vitro" ; rdfs:subClassOf obo:OBI_0002055, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom obo:OBI_0001876 ] ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] . obo:OBI_0002075 obo:IAO_0000111 "MHC ligand assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An immune epitope assay that characterizes the structrue of a MHC-ligand complex, or detects the processing and presentation of a ligand by an antigen presenting cell, or the binding of a ligand to an MHC molecule." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "MHC ligand assay|any method" ; a owl:Class ; rdfs:label "MHC ligand assay" ; rdfs:subClassOf obo:OBI_1110128 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0001503 obo:OBI_0003121 ) ] ] ] ) ] . obo:OBI_0002076 obo:IAO_0000111 "collection of specimens"@en ; obo:IAO_0000112 "Blood cells collected from multiple donors over the course of a study."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A material entity that has two or more specimens as its parts."@en ; obo:IAO_0000116 "Details see tracker: https://sourceforge.net/p/obi/obi-terms/778/" ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "OBIB, OBI" ; dc:source "Biobank" ; a owl:Class ; rdfs:label "collection of specimens"@en ; rdfs:subClassOf obo:BFO_0000040 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0100051 ; owl:onProperty obo:RO_0002351 ] ) ] . obo:OBI_0002077 obo:IAO_0000111 "specimens derived from shared ancestor"@en ; obo:IAO_0000112 "Aliquoting one specimen to multiple tubes and the collection of the aliquoted specimens are a specimen family. Slicing a tissue specimen into multiple sections for microscopy."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A collection of specimens derived from one common specimen via one or more material processing process(es)."@en ; obo:IAO_0000116 "Details see tracker: https://sourceforge.net/p/obi/obi-terms/778/" ; obo:IAO_0000117 "Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000118 "specimen family"@en ; obo:IAO_0000119 "Duke Biobank, OBIB, OBI"@en ; dc:source "Biobank" ; a owl:Class ; rdfs:label "specimens derived from shared ancestor"@en ; rdfs:subClassOf obo:OBI_0002076 . obo:OBI_0002078 obo:IAO_0000111 "specimen set collection process"@en ; obo:IAO_0000112 "Collection of both blood and urine specimens in one clinical visit; Taking out liver and brain specimens during an autopsy."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A specimen collection process that generates multiple specimens from one source (e.g. one organism) during a time period which for the purpose of the study can be considered to be taken at the same sampling time."@en ; obo:IAO_0000117 "Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "OBIB, OBI"@en ; a owl:Class ; rdfs:label "specimen set collection process"@en ; rdfs:subClassOf obo:OBI_0000659 . obo:OBI_0002079 obo:IAO_0000111 "specimens collected in one encounter"@en ; obo:IAO_0000112 "Both blood and urine specimens collected in one clinical visit; liver and brain specimens taken during an autopsy."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A collection of specimens that is collected from one source (e.g. one organism) during a time period which for the purpose of the study can be considered to be taken at the same sampling time."@en ; obo:IAO_0000116 "Details see tracker: https://sourceforge.net/p/obi/obi-terms/778/" ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000118 "specimen set"@en ; obo:IAO_0000119 "OBIB, OBI"@en ; dc:source "Biobank" ; a owl:Class ; rdfs:label "specimens collected in one encounter"@en ; rdfs:subClassOf obo:OBI_0002076 . obo:OBI_0002080 obo:IAO_0000111 "human specimen set"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen set that is collected from one person during a time period which for the purpose of the study can be considered to be taken at the same sampling time."@en ; obo:IAO_0000116 "Details see tracker: https://sourceforge.net/p/obi/obi-terms/778/" ; obo:IAO_0000117 "Person: Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "Duke Biobank, OBIB, OBI"@en ; dc:source "Biobank" ; a owl:Class ; rdfs:label "human specimen set"@en ; rdfs:subClassOf obo:OBI_0002079 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0002079 [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ] ) ] . obo:OBI_0002081 obo:IAO_0000111 "specimens collected longitudinally"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A collection of specimens that was derived from the same source material entity at different time points in order to observe changes in that entity."@en ; obo:IAO_0000116 "Details see tracker: https://sourceforge.net/p/obi/obi-terms/778/" ; obo:IAO_0000117 "Person: Chris Stoeckert"@en ; obo:IAO_0000119 "Bjoern Peters, OBI"@en ; a owl:Class ; rdfs:label "specimens collected longitudinally"@en ; rdfs:subClassOf obo:OBI_0002076 . obo:OBI_0002082 obo:IAO_0000111 "reporter gene assay" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An assay that detects expression of a reporter gene that was inserted under the control of a regulatory sequence of interest." ; obo:IAO_0000117 "Chris Stoeckert", "Paul D. Thomas" ; obo:IAO_0000118 "reporter gene detection assay" ; obo:IAO_0000119 "Paul D. Thomas, Yang Chai; FaceBase" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/781" ; a owl:Class ; rdfs:label "reporter gene assay" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0002083 obo:IAO_0000111 "enhancer activity detection by reporter gene assay" ; obo:IAO_0000112 "PMID 19268701: \"we experimentally concatenated up to four enhancers from different genes and used a transgenic mouse assay to compare the in vivo activity of these compound elements with that of the single modules\"" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A reporter gene assay that detects expression of a reporter gene that was inserted under the control of an enhancer of interest." ; obo:IAO_0000117 "Paul D. Thomas", "Yang Chai" ; obo:IAO_0000118 "enhancer reporter gene assay" ; obo:IAO_0000119 "FaceBase", "PMID 24614317" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/781" ; a owl:Class ; rdfs:label "enhancer activity detection by reporter gene assay" ; rdfs:subClassOf obo:OBI_0002082 . obo:OBI_0002084 obo:IAO_0000111 "transcription cofactor activity region identification by ChIP-Seq assay" ; obo:IAO_0000112 "PMID 19212405: \"we present the results of chromatin immunoprecipitation with the enhancer-associated protein p300 followed by massively parallel sequencing, and map several thousand in vivo binding sites of p300 in mouse embryonic forebrain, midbrain and limb tissue\"" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A ChIP-seq assay that identifies regions of chromatin bound to a chromatin modifying protein, e.g. a histone acetyltransferase." ; obo:IAO_0000117 "Paul D. Thomas", "Yang Chai" ; obo:IAO_0000118 "chromatin modifier binding site identification by ChIP-Seq assay" ; obo:IAO_0000119 "PMID:19212405" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/782" ; a owl:Class ; rdfs:label "transcription cofactor activity region identification by ChIP-Seq assay" ; rdfs:subClassOf obo:OBI_0000716 . obo:OBI_0002085 obo:IAO_0000111 "transcript expression location detection by hybridization chain reaction assay" ; obo:IAO_0000112 "PMID 25977364: \"Multiplexed imaging of mRNA expression using fluorescent hybridization chain reaction (HCR) quantitatively confirmed the expression profiles of lead cells\"" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An in situ hybridization assay in which the location (e.g. anatomical/tissue) of a transcript is detected by a multiplexed fluorescent in situ hybridization, based on orthogonal amplification with hybridization chain reactions (HCR). RNA probes complementary to mRNA targets trigger chain reactions in which fluorophore-labeled RNA hairpins self-assemble into tethered fluorescent amplification polymers." ; obo:IAO_0000117 "Paul D. Thomas", "Yang Chai" ; obo:IAO_0000118 "transcript expression location detection by fluorescent HCR." ; obo:IAO_0000119 "PMID:21037591" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/783" ; a owl:Class ; rdfs:label "transcript expression location detection by hybridization chain reaction assay" ; rdfs:subClassOf obo:OBI_0001686 . obo:OBI_0002086 obo:IAO_0000111 "Tet-assisted bisulfite sequencing assay" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A bisulfite sequencing assay that identifies genomic methylation patterns by using a bisulfite based protocol with the Tet enzyme to differentiate 5-hydroxylmethylcytosine (5hmC) from 5-methylcytosine (5mC) through a step-wise oxidative demethylation of 5mC, converting it to 5-carboxylcytosine (5caC) while keeping 5hmC protected." ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert", "Jason Hilton", "OBI" ; obo:IAO_0000118 "TAB-seq", "Tet-assisted bisulfite sequencing" ; obo:IAO_0000119 "PMID:23196972" ; obo:IAO_0000233 "http://sourceforge.net/p/obi/obi-terms/789/" ; a owl:Class ; rdfs:label "Tet-assisted bisulfite sequencing assay" ; rdfs:subClassOf obo:OBI_0000748 . obo:OBI_0002087 obo:IAO_0000111 "containing a specimen function"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A contain function that involves physical contact with a specimen. This function is typically performed in such a way that the specimen is usable for an investigation or assay."@en ; obo:IAO_0000116 "For details see tracker item: http://sourceforge.net/p/obi/obi-terms/792/"@en ; obo:IAO_0000117 "Chris Stoeckert"@en ; obo:IAO_0000119 "Duke Biobank, OBIB" ; dc:source "Biobank"@en ; a owl:Class ; rdfs:label "containing a specimen function"@en ; rdfs:subClassOf obo:OBI_0000370 . obo:OBI_0002088 obo:IAO_0000111 "specimen container" ; obo:IAO_0000112 "COPAN eSwab, CPT vacutainer, PAXgene Blood DNA tube" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A container with the function of containing a specimen." ; obo:IAO_0000116 "For details see tracker item: http://sourceforge.net/p/obi/obi-terms/792/" ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Duke Biobank, OBIB" ; a owl:Class ; rdfs:label "specimen container" ; rdfs:subClassOf obo:OBI_0000967 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000967 [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0002087 ] ) ] . obo:OBI_0002089 obo:IAO_0000111 "physical store" ; obo:IAO_0000112 "a freezer. a humidity controlled box." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A container with an environmental control function." ; obo:IAO_0000116 "For details see tracker item: http://sourceforge.net/p/obi/obi-terms/793/" ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Duke Biobank, OBIB" ; a owl:Class ; rdfs:label "physical store" ; rdfs:subClassOf obo:OBI_0000967, obo:OBI_0001034 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000967 [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000401 ] ) ] . obo:OBI_0002090 obo:IAO_0000111 "rapid amplification of cDNA ends" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A reverse transcribed polymerase chain reaction that is used to amplify a mRNA sequence between a defined internal site and the 5' or 3' end of the mRNA."@en ; obo:IAO_0000116 "For details see tracker item: https://sourceforge.net/p/obi/obi-terms/790/"@en ; obo:IAO_0000117 "Jason Hilton, Chris Stoeckert"@en ; obo:IAO_0000118 "RACE" ; obo:IAO_0000119 "http://www.clontech.com/US/Products/cDNA_Synthesis_and_Library_Construction/RACE_Rapid_Amplification_of_cDNA_Ends/5_Prime_RACE_and_3_Prime_RACE"@en ; dc:source "ENCODE"@en ; a owl:Class ; rdfs:label "rapid amplification of cDNA ends"@en ; rdfs:subClassOf obo:OBI_0000552 . obo:OBI_0002091 obo:IAO_0000111 "5' rapid amplification of cDNA ends"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A rapid amplication of cDNA ends to amplify a mRNA sequence between a defined internal site and the 5' end of the mRNA."@en ; obo:IAO_0000116 "For details see tracker item: https://sourceforge.net/p/obi/obi-terms/790/"@en ; obo:IAO_0000117 "Jason Hilton, Chris Stoeckert"@en ; obo:IAO_0000118 "5' RACE"@en ; obo:IAO_0000119 "https://www.thermofisher.com/us/en/home/references/protocols/nucleic-acid-amplification-and-expression-profiling/cdna-protocol/5-race-system-for-rapid-amplification-of-cdna-ends.html"@en ; dc:source "ENCODE"@en ; a owl:Class ; rdfs:label "5' rapid amplification of cDNA ends"@en ; rdfs:subClassOf obo:OBI_0002090 . obo:OBI_0002092 obo:IAO_0000111 "3' rapid amplification of cDNA ends"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A rapid amplication of cDNA ends to amplify a mRNA sequence between a defined internal site and the 3' end of the mRNA."@en ; obo:IAO_0000116 "For details see tracker item: https://sourceforge.net/p/obi/obi-terms/790/"@en ; obo:IAO_0000117 "Jason Hilton, Chris Stoeckert"@en ; obo:IAO_0000118 "3' RACE"@en ; obo:IAO_0000119 "https://www.thermofisher.com/us/en/home/references/protocols/nucleic-acid-amplification-and-expression-profiling/cdna-protocol/3-race-system-for-rapid-amplification-of-cdna-ends.html"@en ; dc:source "ENCODE"@en ; a owl:Class ; rdfs:label "3' rapid amplification of cDNA ends"@en ; rdfs:subClassOf obo:OBI_0002090 . obo:OBI_0002093 obo:IAO_0000111 "5' RNA ligase mediated rapid amplification of cDNA ends"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A 5' rapid amplification pf cDNA ends that uses RNA ligase to add an RNA adapter oligonucleotide to intact 5' mRNA ends, allowing the amplification of cDNA only from full-length, capped mRNA."@en ; obo:IAO_0000116 "For details see tracker item: https://sourceforge.net/p/obi/obi-terms/790/"@en ; obo:IAO_0000117 "Jason Hilton, Chris Stoeckert"@en ; obo:IAO_0000118 "5' RLM RACE"@en ; obo:IAO_0000119 "https://tools.thermofisher.com/content/sfs/manuals/cms_056070.pdf"@en ; dc:source "ENCODE"@en ; a owl:Class ; rdfs:label "5' RNA ligase mediated rapid amplification of cDNA ends"@en ; rdfs:subClassOf obo:OBI_0002091 . obo:OBI_0002094 obo:IAO_0000111 "MethylC-Capture sequencing assay" ; obo:IAO_0000112 "MethylC-Capture Sequencing approach was introduced as a cost-effective and customizable alternative method for large-scale interrogation of functionally-active methylomes while simultaneously providing genetic variation information in a proof-of-concept epigenome-wide association study of 72 obese individuals, identifying novel disease-associated variants." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A bisulfite sequencing assay in which a whole-genome sequencing library is prepared, bisulfite converted and amplified, followed by a capture enriching for targeted bisulfite-converted DNA fragments that are are subsequently identified by DNA sequencing." ; obo:IAO_0000117 "Chris Stoeckert", "David Bujold" ; obo:IAO_0000118 "Capture Methylome", "MCC-Seq", "MethylC-Capture Sequencing" ; obo:IAO_0000119 "PMID:26021296" ; a owl:Class ; rdfs:label "MethylC-Capture sequencing assay" ; rdfs:subClassOf obo:OBI_0000748 . obo:OBI_0002095 obo:IAO_0000111 "specimen family creation"@en ; obo:IAO_0000112 "Aliquoting one specimen to multiple tubes, slicing a tissue specimen into multiple sections, processing blood into buffy coat, red cells, and serum."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A material processing that has as its input a specimen and as its output a collection of specimens."@en ; obo:IAO_0000116 "For details see tracker: https://sourceforge.net/p/obi/obi-terms/778/"@en ; obo:IAO_0000117 "Mathias Brochhausen, Chris Stoeckert, Jie Zheng"@en ; obo:IAO_0000119 "OBI, OBIB"@en ; dc:source "Biobank"@en ; a owl:Class ; rdfs:label "specimen family creation"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Class ; owl:intersectionOf (obo:OBI_0000094 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100051 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0002077 ] ) ] . obo:OBI_0002096 obo:IAO_0000111 "carboxyfluorescein succinimidyl ester staining assay measuring epitope specific proliferation of T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A CFSE assay that detects T cell epitope specific proliferation in vitro." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "proliferation|CFSE" ; a owl:Class ; rdfs:label "carboxyfluorescein succinimidyl ester staining assay measuring epitope specific proliferation of T cells" ; rdfs:subClassOf obo:OBI_0002071, obo:OBI_0002106 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0002106 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042098 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom obo:OBI_0001876 ] ] ] ) ] . obo:OBI_0002097 obo:IAO_0000111 "assay measuring the dissociation constant [KD] of a T cell epitope:MHC:TCR complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope binding constant determination assay that measures the dissociation constant KD." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "dissociation constant KD|binding assay|nM" ; a owl:Class ; rdfs:label "assay measuring the dissociation constant [KD] of a T cell epitope:MHC:TCR complex" ; rdfs:subClassOf obo:OBI_0002059 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001536 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_1110057 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000065 ; owl:onProperty obo:IAO_0000039 ] ] ) ] . obo:OBI_0002098 obo:IAO_0000111 "assay measuring the on rate [kon] of a T cell epitope:MHC:TCR complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope binding constant determination assay that measures the on rate." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "on rate|binding assay|M^-1s^-1" ; a owl:Class ; rdfs:label "assay measuring the on rate [kon] of a T cell epitope:MHC:TCR complex" ; rdfs:subClassOf obo:OBI_0002059 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001605 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_1110057 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000282 ; owl:onProperty obo:IAO_0000039 ] ] ) ] . obo:OBI_0002099 obo:IAO_0000111 "assay measuring the off rate [koff] of a T cell epitope:MHC:TCR complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope binding constant determination assay that measures the off rate." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "off rate|binding assay|1/s" ; a owl:Class ; rdfs:label "assay measuring the off rate [koff] of a T cell epitope:MHC:TCR complex" ; rdfs:subClassOf obo:OBI_0002059 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001603 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_1110057 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000106 ; owl:onProperty obo:IAO_0000039 ] ] ) ] . obo:OBI_0002100 obo:IAO_0000111 "assay measuring the association constant [KA] of a T cell epitope:MHC:TCR complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope binding constant determination assay that measures the association constant KA." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "association constant KA|binding assay|1/nM" ; a owl:Class ; rdfs:label "assay measuring the association constant [KA] of a T cell epitope:MHC:TCR complex" ; rdfs:subClassOf obo:OBI_0002059 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001548 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_1110057 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000284 ; owl:onProperty obo:IAO_0000039 ] ] ) ] . obo:OBI_0002101 obo:IAO_0000111 "small-angle scattering assay determining the 3D structure of a B cell epitope:antibody complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A small-angle scattering 3D molecular structure determination assay that characterizes the 3-dimensional molecular structure of a B cell epitope:antibody complex" ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "3D structure|small-angle scattering assay" ; a owl:Class ; rdfs:label "small-angle scattering assay determining the 3D structure of a B cell epitope:antibody complex" ; rdfs:subClassOf obo:OBI_0001721, obo:OBI_0002108 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0002108 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001155 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0003119 ] ] ) ] . obo:OBI_0002102 obo:IAO_0000111 "bio-layer interferometry assay measuring the on rate [kon] of a B cell epitope:antibody complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A bio-layer interferometry assay that measures the on rate of an antigen with an antibody." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "on rate|bio-layer interferometry assay|M^-1s^-1" ; a owl:Class ; rdfs:label "bio-layer interferometry assay measuring the on rate [kon] of a B cell epitope:antibody complex" ; rdfs:subClassOf obo:OBI_0001718, obo:OBI_0002107 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0002107 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001605 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001702 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000282 ; owl:onProperty obo:IAO_0000039 ] ] ) ] . obo:OBI_0002103 obo:IAO_0000111 "bio-layer interferometry assay measuring the off rate [koff] of a B cell epitope:antibody complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A bio-layer interferometry assay that measures the off rate of an antigen with an antibody." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "off rate|bio-layer interferometry assay|1/s" ; a owl:Class ; rdfs:label "bio-layer interferometry assay measuring the off rate [koff] of a B cell epitope:antibody complex" ; rdfs:subClassOf obo:OBI_0001723, obo:OBI_0002107 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0002107 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001603 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001702 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000106 ; owl:onProperty obo:IAO_0000039 ] ] ) ] . obo:OBI_0002104 obo:IAO_0000111 "bio-layer interferometry assay measuring binding of a B cell epitope:antibody complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A bio-layer interferometry assay that detects the binding of an antigen with an antibody." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "qualitative binding|bio-layer interferometry assay" ; a owl:Class ; rdfs:label "bio-layer interferometry assay measuring binding of a B cell epitope:antibody complex" ; rdfs:subClassOf obo:OBI_0001703, obo:OBI_0002107 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0002107 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0003141 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001702 ] ] ) ] . obo:OBI_0002105 obo:IAO_0000111 "bio-layer interferometry assay measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A bio-layer interferometry assay that measures the dissociation constant [KD] of an antigen with an antibody." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "dissociation constant KD|bio-layer interferometry assay|nM" ; a owl:Class ; rdfs:label "bio-layer interferometry assay measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ; rdfs:subClassOf obo:OBI_0001708, obo:OBI_0002107 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0002107 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001536 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001702 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000065 ; owl:onProperty obo:IAO_0000039 ] ] ) ] . obo:OBI_0002106 obo:IAO_0000111 "carboxyfluorescein succinimidyl ester staining assay" ; obo:IAO_0000112 "Measuring T cell proliferation based on the progressive halving of CFSE fluorescence within daughter cells following each cell division." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay using carboxyfluorescein succinimidyl ester staining." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000118 "CFSE assay" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "carboxyfluorescein succinimidyl ester staining assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003585 ] ) ] . obo:OBI_0002107 obo:IAO_0000111 "bio-layer interferometry assay" ; obo:IAO_0000112 "Detecting the presence of an antibody in a cell culture supernatant by detecting a shift in the interference pattern reflected from a layer of immobilized protein to which the antibody binds." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A binding assay that detects a shift in the interference pattern reflected from a layer of immobilized material on the biosensor tip to measure binding to- or dissociating from the material on the biosensor." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000118 "biolayer interferometry, BLI" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "bio-layer interferometry assay" ; rdfs:subClassOf obo:OBI_0001146 . obo:OBI_0002108 obo:IAO_0000111 "small-angle scattering 3D molecular structure determination assay" ; obo:IAO_0000112 "Targeting a solution of antibody bound to a protein with a neutron beam to determine the binding site of the antibody on the protein" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A 3D molecular structure determination assay in which the scattering pattern of a neutron or x-ray beam targeted at a material entity is recorded at small angles relative to the incident beam to determine the size, shape and structure of the material entity examined." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000118 "SAXS" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "small-angle scattering 3D molecular structure determination assay" ; rdfs:subClassOf obo:OBI_0003117 . obo:OBI_0002109 obo:IAO_0000111 "Human 6x630K CGH Whole Genome Tiling Array" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A tiling array which is manufactured by the Nimblegen corporation to analyze DNA sequence copy number by comparative genomic hybridization for human DNA against 6x630,000 features." ; obo:IAO_0000116 "Term request: https://sourceforge.net/p/obi/obi-terms/791/" ; obo:IAO_0000117 "Jason Hilton, Chris Stoeckert, Bjoern Peters, OBI-group" ; obo:IAO_0000118 "NimbleGen Human 6x630K CGH Whole Genome Tiling Array" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?token=snolquwezzwdxuj&acc=GPL18318" ; a owl:Class ; rdfs:label "Human 6x630K CGH Whole Genome Tiling Array" ; rdfs:subClassOf obo:OBI_0001307, [ a owl:Restriction ; owl:hasValue obo:OBI_0001855 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002110 obo:IAO_0000111 "digital object identifier"@en ; obo:IAO_0000112 "The doi symbol: \"10.1109/5.771073\" resolves to ieee website: http://ieeexplore.ieee.org/xpl/articleDetails.jsp?reload=true&arnumber=771073" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A centrally registered identifier symbol used to uniquely identify objects given by International DOI Foundation. The DOI system is particularly used for electronic documents such as journal articles." ; obo:IAO_0000116 """Discussed on Aug 22, 2016 OBI dev call. Details see tracker: https://sourceforge.net/p/obi/obi-terms/818/""" ; obo:IAO_0000117 "OBI developers" ; obo:IAO_0000118 "DOI" ; obo:IAO_0000119 """https://en.wikipedia.org/wiki/Digital_object_identifier https://www.doi.org/""" ; a owl:Class ; rdfs:label "digital object identifier"@en ; rdfs:subClassOf obo:IAO_0000577 . obo:OBI_0002111 obo:IAO_0000111 "enhanced cross-linking immunoprecipitation high-throughput sequencing assay" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An iCLIP assay that is enhanced to robustly identify protein-RNA interactions with high efficiency through improvements in library preparation of RNA fragments." ; obo:IAO_0000117 "Chris Stoeckert", "Jason Hilton" ; obo:IAO_0000118 "eCLIP" ; obo:IAO_0000119 "PMID:27018577" ; a owl:Class ; rdfs:label "enhanced cross-linking immunoprecipitation high-throughput sequencing assay" ; rdfs:subClassOf obo:OBI_0002043 . obo:OBI_0002112 obo:IAO_0000111 "small RNA sequencing assay" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An RNA-seq assay which is targeting small RNA (< 200 bp) sequences such as, but not exclusive to, miRNAs using, for example, small RNA library preparation kits." ; obo:IAO_0000117 "Chris Stoeckert", "Jason Hilton", "Mark A. Miller" ; obo:IAO_0000118 "short RNA-seq", "small RNA-seq" ; obo:IAO_0000119 "url:http://science.sciencemag.org/content/316/5830/1484.full", "url:http://www.illumina.com/techniques/sequencing/rna-sequencing/small-rna-seq.html" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/859" ; a owl:Class ; rdfs:label "small RNA sequencing assay" ; rdfs:subClassOf obo:OBI_0001271 . obo:OBI_0002113 obo:IAO_0000111 "bromouridine labeling and sequencing assay" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An RNA-seq assay to identify spans of nascent transcription in the genome through isolation of recent bromouridine (Bru) labelled RNAs." ; obo:IAO_0000117 "Chris Stoeckert", "Jason Hilton" ; obo:IAO_0000118 "Bru-seq" ; obo:IAO_0000119 "PMC:4009065" ; a owl:Class ; rdfs:label "bromouridine labeling and sequencing assay" ; rdfs:subClassOf obo:OBI_0001271 . obo:OBI_0002114 obo:IAO_0000111 "bromouridine pulse-chase and sequencing assay" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An RNA-seq assay to identify RNA populations of specific ages through isolation of RNAs first labelled with bromouridine (Bru) followed by chasing in uridine for different periods of time." ; obo:IAO_0000117 "Chris Stoeckert", "Jason Hilton" ; obo:IAO_0000118 "BruChase-seq" ; obo:IAO_0000119 "PMC:4009065" ; a owl:Class ; rdfs:label "bromouridine pulse-chase and sequencing assay" ; rdfs:subClassOf obo:OBI_0001271 . obo:OBI_0002115 obo:IAO_0000111 "cytometry time of flight assay" ; obo:IAO_0000112 "Whole human blood samples were incubated with lipopolysaccharide (LPS) to examine dose-dependent signaling responses within the toll-like receptor 4 (TLR4) pathway. After LPS stimulation, rare earth metal tagged antibodies against phenotypic markers were used to stain the blood sample (Nd143-CD45RA, Nd145-CD4, Er170-CD3, Sm152-TCR__, Pr141-CD7, Nd146-CD8, Nd142-CD19). A Fluidigm CyTOF version 1 instrument equipped with CyTOF software version 5.1.648 was used to measure and analyze the levels of antibody staining reflective of the level of expression of those surface receptors." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay in which the presence of molecules of interest on or in cells is indicated by binding of antibodies labeled with rare earth element tags which are detected by time-of-flight mass spectrometry." ; obo:IAO_0000117 "ImmPort" ; obo:IAO_0000118 "CyTOF", "mass cytometry assay" ; obo:IAO_0000119 "PMID:26190063" ; a owl:Class ; rdfs:label "cytometry time of flight assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002743 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33321 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33321 ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000470 obo:OBI_0003368 ) ] ] . obo:OBI_0002116 obo:IAO_0000111 "high performance liquid chromotography assay" ; obo:IAO_0000112 "On-line coupled immunoaffinity chromatography-reversed-phase high-performance liquid chromatography (IAC-HPLC) with detection by quadrupole ion trap mass spectrometry using a particle beam interface has been developed for the determination of the steroids, dexamethasone and flumethasone. HEMA (polyhydroxyethylmethacrylate) was evaluated as a support material for the anti-dexamethasone antibodies used in IAC. Antibody cross-reactivity and non-specific binding have been investigated for the HEMA bound anti-dexamethasone IAC column. The on-line IAC-HPLC-MS determination of dexamethasone and flumethasone in post-administration equine urine samples showed precisions (R.S.D.) of 8.0 and 7.1%, respectively, with limits of detection in the range 3-4 ng/ml." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analytical chromatography assay that utilizes a high performance liquid chromatography instrument for separation of compounts in a solution." ; obo:IAO_0000117 "ImmPort" ; obo:IAO_0000118 "HPLC" ; obo:IAO_0000119 "PMID:9491555" ; a owl:Class ; rdfs:label "high performance liquid chromotography assay" ; rdfs:subClassOf obo:OBI_0001630 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001630 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001057 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001057 ] ) ] ) ] . obo:OBI_0002117 obo:IAO_0000111 "whole genome sequencing assay" ; obo:IAO_0000112 "WGS permits comprehensive sequencing of introns and exons, whereas whole exome sequencing (WES) allows deeper sequencing of exonic regions at a lower cost. Due to the large number of genetic variants found in each genome, it is necessary to use filtering approaches to distinguish deleterious from benign variants. WES has been used successfully to identify novel genetic causes of primary immunodeficiency. Complex structural variations and non-Mendelian disorders remain challenges for WGS." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencing assay that intends to provide information about the sequence of an entire genome of an organism." ; obo:IAO_0000116 "Genotyping assays should ideally identify which part of the genome the information is about. We do not currently have a good way to do this. That information should be added later." ; obo:IAO_0000117 "ImmPort" ; obo:IAO_0000118 "WGS" ; obo:IAO_0000119 "PMID:23095910", "PMID:25827230" ; a owl:Class ; rdfs:label "whole genome sequencing assay" ; rdfs:subClassOf obo:OBI_0000626 . obo:OBI_0002118 obo:IAO_0000111 "exome sequencing assay" ; obo:IAO_0000112 "DNA was extracted from the Ficoll pellet of blood taken from congenital asplenia patients. Unamplified, high-molecular weight, RNase-treated genomic DNA (4_6 _g) was used for whole exome sequencing (WES) with the use of Agilent 71 Mb (V4 + UTR) singlesample capture and an Illumina HiSeq 2000. Sequencing was carried out so as to obtain 30_ coverage from 2 _ 100-bp paired-end reads. We used the Annovar tool (25) to annotate the resulting highquality (HQ) variants. In the regions targeted by WES capture (81.5% of the consensus coding genome), the mean numbers of single-nucleotide variants (SNVs) and small insertions/deletions (indels) detected per sample were 84,192 and13,325, respectively. After filtering, a mean of 74,398 (95.3%) high-quality (HQ) SNVs and 9,033 (70.6%) HQ indels were called. A mean of 105 coding HQ SNVs and 32 indels was identified." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencing assay that intends to provide information about the sequence of the protein coding components of a genome (exons)." ; obo:IAO_0000117 "ImmPort" ; obo:IAO_0000118 "WES" ; obo:IAO_0000119 "PMID:25827230" ; a owl:Class ; rdfs:label "exome sequencing assay" ; rdfs:subClassOf obo:OBI_0000626 . obo:OBI_0002119 obo:IAO_0000111 "microscopy assay" ; obo:IAO_0000112 "Lung, liver, and spleen tissue samples were collected from female BALB/c mice and fixed in 100% formalin solution, embedded in paraffin, sectioned, and stained with hematoxylin and eosin. The stained samples were examined for signs of pathological changes under light microscopy." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An imaging assay that utilizes a microscope to magnify features of the visualized material of interest that are not visible to naked eye." ; obo:IAO_0000117 "ImmPort" ; obo:IAO_0000119 "PMID:21685355" ; a owl:Class ; rdfs:label "microscopy assay" ; rdfs:subClassOf obo:OBI_0000185 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000185 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400169 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400169 ] ) ] ) ] . obo:OBI_0002120 obo:IAO_0000111 "mixed lymphocyte reaction assay" ; obo:IAO_0000112 "T cells were separated from PBL of laboratory volunteers and used as responder cells (R). Mitomycin C-treated allogeneic mAPC enriched populations were used as stimulators (S), incubated for 5 days, pulsed with 3H-thymidine (3H-TdR) for 16 hours, harvested, and radioactivity counted using a beta scintillation counter to measure proliferation of the 3H-thymidine labeled cells." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay where lymphocytes from two individuals are co-cultured with the lymphocytes from one of the allogeneic individuals (Responders) being labeled (with 3H Thymidine or BrdU) and the proliferation of the labeled cells is measured, which is thought to reflect recognition of histocompatibility antigens on the unlabeled cells (stimulators)." ; obo:IAO_0000117 "ImmPort" ; obo:IAO_0000118 "MLR" ; obo:IAO_0000119 "PMID:14969764" ; a owl:Class ; rdfs:label "mixed lymphocyte reaction assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0002744 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0002744 ] ) ] . obo:OBI_0002121 obo:IAO_0000111 "killer cell immunoglobulin-like receptor typing assay" ; obo:IAO_0000112 "DNA was isolated from PBMCs from healthy donors.The single-nucleotide polymorphism (SNP) assay was performed on an HT7900 Sequence Detection System (Applied Biosystems) following the allelic discrimination assay protocol provided by the manufacturer. Primers for the assay were designed in such a way that they amplified all the alleles of a particular HLA type (HLA-B or HLA-C) as well as the amplicon containing the polymorphic region of interest. Two probes were designed with a single mismatch between them. Each probe bound only one group of alleles and was labeled with either 6FAM or VIC fluorescent dye at its 5_ end. The 3_ end of the probes contained a quencher. For KIR2DL1 functional allele typing, the probe was designed based on a single-nucleotide mismatch at amino acid position 245 in the mature protein. A universal primer was designed that could specifically amplify all the alleles of KIR2DL1.The SNP assay was run on the HT7900 using the same protocol as described for KIR ligand typing. Results showed that 20 individuals had only arginine at amino acid position 245 of KIR2DL1, 5 were heterozygous for arginine and cysteine, and 1 had only cysteine in that position.Thus, this approach was useful not only for the identification of functional groups of KIR alleles, but also for determining the presence of the KIR gene itself." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A genotyping assay in which the alleles of genes encoding for killer cell immunoglobulin-like receptors are determined." ; obo:IAO_0000116 "Genotyping assays should ideally identify which part of the genome the information is about. We do not currently have a good way to do this. That information should be added later." ; obo:IAO_0000117 "ImmPort" ; obo:IAO_0000118 "KIR typing" ; obo:IAO_0000119 "PMID:21239231" ; a owl:Class ; rdfs:label "killer cell immunoglobulin-like receptor typing assay" ; rdfs:subClassOf obo:OBI_0000435 . obo:OBI_0002122 obo:IAO_0000111 "major histocompatibility typing assay" ; obo:IAO_0000112 "Blood samples from Holstein-Friesian heifer calves were used to isolate white blood cell (WBC) pellets, from which total RNA was extracted using Tri-reagent and cDNA generated using a Reverse Transcription Kit, both_ according to the manufacturers? instructions. An alignment of sequences of known bovine MHCI gene cDNAs, as presented in the IPD-MHC database (May 2014), was used to design a series of 3_ (for) and 5_ (rev) pan-MHCI primers. cDNA from individual animals was subject to PCR amplification in two separate reactions using either the For1/Rev2 or the For3/Rev1 primer pairs. For each sample primers using a unique combination of MID tags were used to allow subsequent de-multiplexing of the sequence data. PCRs were conducted using the Phusion High-Fidelity PCR kit. Following amplification, 5?_l of PCR products from each sample were pooled, purified using Agencourt AMPure XP Beads and run on a 1.5?% agarose gel. Bands of the appropriate size_ were extracted and purified using the Qiagen Gel extraction kit. Libraries were submitted to Edinburgh Genomics where after standard quality control procedures they underwent 300 base paired-end sequencing on an Illumina MiSeq v3. Data were separated into reads generated from For1Rev2 and For3Rev1 primer pairs, generating separate datasets for up to 192 samples. Within each sample, reads were clustered into unique variants which were subsequently compared using BLAST against a database of the previously identified bovine MHCI sequences. This process identified >140 novel classical MHCI genes and defined 62 novel MHCI haplotypes, dramatically expanding the known bovine MHCI repertoire." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A genotyping assay in which the alleles of genes encoding for major histocompatibility complex molecules are determined." ; obo:IAO_0000116 "Genotyping assays should ideally identify which part of the genome the information is about. We do not currently have a good way to do this. That information should be added later." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000118 "MHC typing, HLA typing" ; obo:IAO_0000119 "PMC:2628004", "PMID:27516207" ; a owl:Class ; rdfs:label "major histocompatibility typing assay" ; rdfs:subClassOf obo:OBI_0000435 . obo:OBI_0002123 obo:IAO_0000111 "IHC slide staining"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A staining using labeled antibodies, i.e. the analytical part of immunohistochemistry. The staining is applied to fixed specimens on slides to identify biomarkers in tissues."@en ; obo:IAO_0000117 "Chris Stoeckert, Ned Haubein"@en ; obo:IAO_0000119 "http://www.agilent.com/cs/library/technicaloverviews/public/08002_ihc_staining_methods.pdf"@en ; a owl:Class ; rdfs:label "IHC slide staining"@en ; rdfs:subClassOf obo:OBI_0302887, [ a owl:Class ; owl:intersectionOf (obo:OBI_0302887 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OMIABIS_0000052 ] ) ] . obo:OBI_0002124 obo:IAO_0000111 "H&E slide staining"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A staining using hematoxylin and eosin. The staining is applied to fixed specimens on slides to observe the whole structure and morphology of cells in a tissue; nuclei are stained dark blue/purple while cytoplasm is stained pink."@en ; obo:IAO_0000117 "Chris Stoeckert, Ned Haubein"@en ; obo:IAO_0000119 "http://www.histalim.com/accueil/activities/our-services/histology/hematoxylin-eosin-2/"@en ; a owl:Class ; rdfs:label "H&E slide staining"@en ; rdfs:subClassOf obo:OBI_0302887, [ a owl:Class ; owl:intersectionOf (obo:OBI_0302887 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OMIABIS_0000052 ] ) ] . obo:OBI_0002125 obo:IAO_0000111 "H&E-stained fixed tissue slide specimen"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A fixed tissue slide specimen that is the output of H&E slide staining."@en ; obo:IAO_0000117 "Chris Stoeckert, Ned Haubein"@en ; obo:IAO_0000119 "OBIB, OBI"@en ; a owl:Class ; rdfs:label "H&E-stained fixed tissue slide specimen"@en ; rdfs:subClassOf obo:OMIABIS_0000052, [ a owl:Class ; owl:intersectionOf (obo:OMIABIS_0000052 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002124 ] ) ] . obo:OBI_0002126 obo:IAO_0000111 "IHC-stained fixed tissue slide specimen"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A fixed tissue slide specimen that is the output of immunohistochemistry slide staining."@en ; obo:IAO_0000117 "Chris Stoeckert, Ned Haubein"@en ; obo:IAO_0000118 "immunohistochemistry slide specimen"@en ; obo:IAO_0000119 "OBIB, OBI"@en ; a owl:Class ; rdfs:label "IHC-stained fixed tissue slide specimen"@en ; rdfs:subClassOf obo:OMIABIS_0000052, [ a owl:Class ; owl:intersectionOf (obo:OMIABIS_0000052 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002123 ] ) ] . obo:OBI_0002127 obo:IAO_0000111 "single cell specimen"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cell specimen that contains only one cell." ; obo:IAO_0000116 "Requested by Sirarat Sarntivijai (EBI). Details see tracker: https://sourceforge.net/p/obi/obi-terms/828/" ; obo:IAO_0000117 "PERSON: Jie Zheng, Alexander Diehl" ; obo:IAO_0000119 "PERSON: Jie Zheng, Alexander Diehl" ; a owl:Class ; rdfs:label "single cell specimen"@en ; rdfs:subClassOf obo:OBI_0001468 . obo:OBI_0002128 obo:IAO_0000111 "Illumina Genome Analyzer" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A DNA sequencer manufactured by Solexa as one of its first sequencer lines, launched in 2006, and capable of sequencing 1 gigabase (Gb) of data in a single run." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jason Hilton" ; obo:IAO_0000118 "Illumina Genome Analyzer I" ; obo:IAO_0000119 "http://www.illumina.com/technology/next-generation-sequencing/solexa-technology.html" ; a owl:Class ; rdfs:label "Illumina Genome Analyzer" ; rdfs:subClassOf obo:OBI_0400103 . obo:OBI_0002129 obo:IAO_0000111 "Illumina HiSeq X Ten" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A DNA sequencer that consists of a set of 10 HiSeq X Sequencing Systems." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jason Hilton, Sagar Jain, Richard Scheuermann" ; obo:IAO_0000118 "HiSeq X Ten" ; obo:IAO_0000119 "http://www.illumina.com/systems/hiseq-x-sequencing-system/system.html" ; a owl:Class ; rdfs:label "Illumina HiSeq X Ten" ; rdfs:subClassOf obo:OBI_0400103 . obo:OBI_0002130 obo:IAO_0000111 "Illumina Infinium Omni5Exome-4 Kit" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An Illumina BeadChip which is an array that interrogates over 4.3 million whole-genome variants for genotyping and copy number variation." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jason Hilton" ; obo:IAO_0000119 "http://www.illumina.com/products/by-type/microarray-kits/infinium-omni5-exome.html" ; a owl:Class ; rdfs:label "Illumina Infinium Omni5Exome-4 Kit" ; rdfs:subClassOf obo:OBI_0001869 . obo:OBI_0002131 obo:IAO_0000111 "Illumina Infinium MethylationEPIC v1.0 BeadChip" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An Illumina methylation BeadChip which is an array that interrogates ~ 850,000 methylation sites per sample at single-nucleotide resolution." ; obo:IAO_0000117 "Person: Chris Stoeckert, Jason Hilton" ; obo:IAO_0000119 "http://www.illumina.com/content/dam/illumina-marketing/documents/products/datasheets/humanmethylationepic-data-sheet-1070-2015-008.pdf" ; a owl:Class ; rdfs:label "Illumina Infinium MethylationEPIC v1.0 BeadChip" ; rdfs:subClassOf obo:OBI_0001870 . obo:OBI_0002132 obo:IAO_0000111 "pulse stable isotope labeling by amino acids in cell culture" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that detects differences in protein abundance using samples that have been metabolically labeled in vivo with a stable non-radioactive heavy isotope containing amino acid for a short period of time. After diluting the pulsed cells into growth media without label, high resolution mass spectrometry-based proteomics is used to analyze the time-dependent decay and determine protein stability." ; obo:IAO_0000117 "Rob Nash" ; obo:IAO_0000118 "dynamic SILAC", "pulse SILAC", "pulsed SILAC" ; obo:IAO_0000119 "PMID:18954100", "PMID:19053139" ; a owl:Class ; rdfs:label "pulse stable isotope labeling by amino acids in cell culture" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0002133 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific chemokine (C-C motif) ligand 20 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects chemokine (C-C motif) ligand 20 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, James Overton, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL20/MIP-3a release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific chemokine (C-C motif) ligand 20 production by T cells" ; rdfs:subClassOf obo:OBI_0002134, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0036392 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002134 obo:IAO_0000111 "assay measuring epitope specific chemokine (C-C motif) ligand 20 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects chemokine (C-C motif) ligand 20 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, James Overton, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "CCL20/MIP-3a release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific chemokine (C-C motif) ligand 20 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0036392 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002135 obo:IAO_0000111 "has specified value"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A relation between a value specification and a literal." ; obo:IAO_0000116 "This is not an RDF/OWL object property. It is intended to link a value found in e.g. a database column of 'M' (the literal) to an instance of a value specification class, which can then be linked to indicate that this is about the biological gender of a human subject." ; obo:IAO_0000119 "OBI" ; a owl:DatatypeProperty ; rdfs:domain obo:OBI_0001933 ; rdfs:label "has specified value"@en . obo:OBI_0002136 obo:IAO_0000111 "RNA Integrity Number calculation" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A data transformation using the RIN algorithm to generate a quality measure of RNA based on features from an electrophoretic trace." ; obo:IAO_0000117 "Chris Stoeckert, Bjoern Peters" ; obo:IAO_0000118 "RIN calculation" ; obo:IAO_0000119 "https://www.agilent.com/cs/library/applications/5989-1165EN.pdf" ; a owl:Class ; rdfs:label "RNA Integrity Number calculation"@en ; rdfs:subClassOf obo:OBI_0200000, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:IAO_0000109 [ a owl:Restriction ; owl:onProperty obo:OBI_0001938 ; owl:someValuesFrom obo:OBI_0002137 ] ) ] ] . obo:OBI_0002137 obo:IAO_0000111 "RNA Integrity Number value specification" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A value specification that specifies the value of the RNA Integrity Number as a real value between 1 (most degraded) and 10 (most intact)." ; obo:IAO_0000117 "Chris Stoeckert, Bjoern Peters" ; obo:IAO_0000118 "RIN value specification" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "RNA Integrity Number value specification"@en ; rdfs:subClassOf obo:OBI_0001933 . obo:OBI_0002138 obo:IAO_0000111 "temperature value specification" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A value specification that specifies the temperature of some thing." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "temperature value specification"@en ; rdfs:subClassOf obo:OBI_0001933, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0001927 ; owl:someValuesFrom obo:PATO_0000146 ] [ a owl:Restriction ; owl:allValuesFrom obo:UO_0000005 ; owl:onProperty obo:IAO_0000039 ] ) ] . obo:OBI_0002139 obo:IAO_0000111 "volume value specification" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A value specification that specifies the volume of some thing." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "volume value specification"@en ; rdfs:subClassOf obo:OBI_0001933, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0001927 ; owl:someValuesFrom obo:PATO_0000918 ] [ a owl:Restriction ; owl:allValuesFrom obo:UO_0000095 ; owl:onProperty obo:IAO_0000039 ] ) ] . obo:OBI_0002140 obo:IAO_0000111 "temperature measurement assay" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An assay to determine the temperature of an evaluant." ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "temperature measurement assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:IAO_0000109 [ a owl:Restriction ; owl:onProperty obo:OBI_0001938 ; owl:someValuesFrom obo:OBI_0002138 ] ) ] ] . obo:OBI_0002141 obo:IAO_0000111 "volume measurement assay" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An assay to determine the volume of an evaluant." ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "volume measurement assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:IAO_0000109 [ a owl:Restriction ; owl:onProperty obo:OBI_0001938 ; owl:someValuesFrom obo:OBI_0002139 ] ) ] ] . obo:OBI_0002142 obo:IAO_0000111 "Nanostring nCounter miRNA expression assay" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A microRNA profiling assay using digital molecular barcoding technology to quantify target microRNA molecules without the need for amplification." ; obo:IAO_0000117 "Chris Stoeckert", "Jason Hilton" ; obo:IAO_0000118 "microRNA counts" ; obo:IAO_0000119 "PMID:26729350", "url:http://www.nanostring.com/applications/technology" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/806" ; obo:IAO_0000234 "ENCODE DCC" ; a owl:Class ; rdfs:label "Nanostring nCounter miRNA expression assay" ; rdfs:subClassOf obo:OBI_0001926 . obo:OBI_0002143 obo:IAO_0000111 "bromouride labeling and sequencing after UV exposure" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An RNA-seq assay to identify transcription start sites and active enhancer elements through isolation of bromouridine (Bru) labelled RNAs after UV light exposure introduces transcription-blocking lesions." ; obo:IAO_0000117 "Chris Stoeckert", "Jason Hilton" ; obo:IAO_0000118 "BruUV-seq" ; obo:IAO_0000119 "PMC:4675984" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/827" ; obo:IAO_0000234 "ENCODE DCC" ; a owl:Class ; rdfs:label "bromouride labeling and sequencing after UV exposure" ; rdfs:subClassOf obo:OBI_0001271 . obo:OBI_0002144 obo:IAO_0000111 "extrachromosomal circular DNA sequencing assay" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An assay which aims at identifying the endogenous population of extrachromosomal circular DNA originating from a subset of genomic loci and potentially having profound consequences on the regulatory and coding capabilities of these regions. The assay includes creation of a library out of the circular DNA molecules and subsequent sequencing using parallelized sequencing methods." ; obo:IAO_0000117 "Chris Stoeckert", "Jason Hilton" ; obo:IAO_0000118 "circulome-seq", "eccDNA-seq" ; obo:IAO_0000119 "url:http://biorxiv.org/content/early/2017/04/19/128686" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/830" ; obo:IAO_0000234 "ENCODE DCC" ; a owl:Class ; rdfs:label "extrachromosomal circular DNA sequencing assay" ; rdfs:subClassOf obo:OBI_0000626 . obo:OBI_0002145 obo:IAO_0000111 "antigen specific antibodies assay" ; obo:IAO_0000112 "Test performed using antibodies produced by human B-cells that bind with human immunodeficiency virus (HIV) antigens" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the presence or amount of antibodies to a specified antigen." ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert", "James Overton", "Randi Vita" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/825" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "antigen specific antibodies assay" ; rdfs:subClassOf obo:OBI_0000443 . obo:OBI_0002146 obo:IAO_0000111 "HIV antibody assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antigen specific antibodies assay that is meant to detect antibodies that bind to human immunodeficiency virus (HIV) antigens." ; obo:IAO_0000116 "HIV-1 and HIV-2 are two different viruses (http://i-base.info/qa/36)" ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert", "James Overton", "Randi Vita" ; obo:IAO_0000118 "HIV I/II Ab assay" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/825" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "HIV antibody assay" ; rdfs:subClassOf obo:OBI_0002145, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:NCBITaxon_11676 obo:NCBITaxon_11709 ) ] ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:NCBITaxon_11676 obo:NCBITaxon_11709 ) ] ] ) ] ] ) ] . obo:OBI_0002147 obo:IAO_0000111 "HIV group O antibody assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antigen specific antibodies assay that is meant to detect antibodies that bind to human immunodeficiency virus (HIV) group O antigens." ; obo:IAO_0000116 "https://www.cdc.gov/mmwr/preview/mmwrhtml/00042810.htm" ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert", "James Overton", "Randi Vita" ; obo:IAO_0000118 "HIV I/II Plus O assay" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/825" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "HIV group O antibody assay" ; rdfs:subClassOf obo:OBI_0002145, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:NCBITaxon_11676 obo:NCBITaxon_11709 obo:NCBITaxon_388799 ) ] ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:NCBITaxon_11676 obo:NCBITaxon_11709 obo:NCBITaxon_388799 ) ] ] ) ] ] ) ] . obo:OBI_0002148 obo:IAO_0000111 "surface HBV antibody assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antigen specific antibodies assay that is meant to detect antibodies that bind to hepatitis B virus (HBV) surface antigens." ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert", "James Overton", "Randi Vita" ; obo:IAO_0000118 "HBsAb assay" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/825" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "surface HBV antibody assay" ; rdfs:subClassOf obo:OBI_0002145, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_10407 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_10407 ] ) ] ] ) ] . obo:OBI_0002149 obo:IAO_0000111 "core HBV antibody assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antigen specific antibodies assay that is meant to detect antibodies that bind to hepatitis B virus (HBV) core antigens." ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert", "James Overton", "Randi Vita" ; obo:IAO_0000118 "HBcAb assay" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/825" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "core HBV antibody assay" ; rdfs:subClassOf obo:OBI_0002145, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_10407 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_10407 ] ) ] ] ) ] . obo:OBI_0002150 obo:IAO_0000111 "core HBV IgM antibody assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antigen specific antibodies assay that is meant to detectimmunoglobulin M (IgM) antibodies that bind to hepatitis B virus (HBV) core antigens." ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert", "James Overton", "Randi Vita" ; obo:IAO_0000118 "HBcAb-IgM assay" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/825" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "core HBV IgM antibody assay" ; rdfs:subClassOf obo:OBI_0002145, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_10407 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_10407 ] ) ] ] ) ] . obo:OBI_0002151 obo:IAO_0000111 "HCV antibody assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antigen specific antibodies assay that is meant to detect antibodies that bind to Hepacivirus C (HCV) antigens." ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert", "James Overton", "Randi Vita" ; obo:IAO_0000118 "HCV Ab assay" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/825" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "HCV antibody assay" ; rdfs:subClassOf obo:OBI_0002145, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_11103 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_11103 ] ) ] ] ) ] . obo:OBI_0002152 obo:IAO_0000111 "EBV IgG antibody assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antigen specific antibodies assay that is meant to detect immunoglobulin G (IgG) antibodies that bind to Epstein-Barr virus (EBV) antigens." ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert", "James Overton", "Randi Vita" ; obo:IAO_0000118 "EBV IgG Ab assay" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/825" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "EBV IgG antibody assay" ; rdfs:subClassOf obo:OBI_0002145, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_10376 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_10376 ] ) ] ] ) ] . obo:OBI_0002153 obo:IAO_0000111 "EBV IgM antibody assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antigen specific antibodies assay that is meant to detect immunoglobulin M (IgM) antibodies that bind to Epstein-Barr virus (EBV) antigens." ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert", "James Overton", "Randi Vita" ; obo:IAO_0000118 "EBV IgM Ab assay" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/825" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "EBV IgM antibody assay" ; rdfs:subClassOf obo:OBI_0002145, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_10376 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_10376 ] ) ] ] ) ] . obo:OBI_0002154 obo:IAO_0000111 "CMV antibody assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antigen specific antibodies assay that is meant to detect antibodies that bind to cytomegalovirus (CMV) antigens." ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert", "James Overton", "Randi Vita" ; obo:IAO_0000118 "CMV Ab assay" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/825" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "CMV antibody assay" ; rdfs:subClassOf obo:OBI_0002145, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_10358 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_10358 ] ) ] ] ) ] . obo:OBI_0002155 obo:IAO_0000111 "venereal disease research laboratory test" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that is meant to detect general antibodies that react with substances that are produced by cellular damage caused by Treponema pallidum indicating a syphilis infection. VDRL tests require a microscope and can be done on cerebrospinal fluid as well as blood." ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert", "James Overton", "Randi Vita" ; obo:IAO_0000118 "VDRL test" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/825" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "venereal disease research laboratory test" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0019814 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:GO_0019814 ] ) ] . obo:OBI_0002156 obo:IAO_0000111 "rapid plasma reagin test" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that is meant to detect with the aid of carbon or charcoal particles general antibodies that react with substances that are produced by cellular damage caused by Treponema pallidum indicating a syphilis infection. RPR tests can be done without a microscope." ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert", "James Overton", "Randi Vita" ; obo:IAO_0000118 "RPR assay" ; obo:IAO_0000119 "url:http://www.differencebetween.net/science/health/difference-between-vdlr-and-rpr/" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/825" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "rapid plasma reagin test" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0019814 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:GO_0019814 ] ) ] . obo:OBI_0002157 obo:IAO_0000111 "HBV surface antigen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that is meant to detect hepatitis B virus (HBV) surface antigens." ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert", "James Overton", "Randi Vita" ; obo:IAO_0000118 "HBsAg assay" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/825" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "HBV surface antigen assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NCBITaxon_10407 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:NCBITaxon_10407 ] ) ] . obo:OBI_0002158 obo:IAO_0000111 "HIV-1 nucleic acid testing" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that is meant to detect human immunodeficiency virus (HIV-1) nucleic acids." ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert", "James Overton", "Randi Vita" ; obo:IAO_0000118 "HIV-1 NAT" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/825" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "HIV-1 nucleic acid testing" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33696 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:NCBITaxon_11676 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33696 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:NCBITaxon_11676 ] ) ] ] ) ] . obo:OBI_0002159 obo:IAO_0000111 "HCV nucleic acid testing" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that is meant to detect hepatitis C virus (HCV) nucleic acids." ; obo:IAO_0000117 "Bjoern Peters", "Chris Stoeckert", "James Overton", "Randi Vita" ; obo:IAO_0000118 "HCV NAT" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/825" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "HCV nucleic acid testing" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33696 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:NCBITaxon_11103 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33696 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:NCBITaxon_11103 ] ) ] ] ) ] . obo:OBI_0002160 obo:IAO_0000111 "multiplexed indexed T7 ChIP-seq assay" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A ChIP-seq assay which leverages T7 promoter amplification to allow low sample input and chromatin barcoding and pool-and-split multiplexing for high-throughput, quantitative profiling of chromatin states." ; obo:IAO_0000117 "Chris Stoeckert", "Jason Hilton" ; obo:IAO_0000118 "Mint-ChIP", "Mint-ChIP-seq" ; obo:IAO_0000119 "url:http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00863-1" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/829" ; obo:IAO_0000234 "ENCODE DCC" ; a owl:Class ; rdfs:label "multiplexed indexed T7 ChIP-seq assay" ; rdfs:subClassOf obo:OBI_0000716 . obo:OBI_0002161 obo:IAO_0000111 "systematic evolution of ligands by exponential enrichment assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A binding assay that identifies protein-binding sites on nucleic acids by selecting high-affinity target ligands from a randomized pool. The process is repeated in rounds, then the bound nucleic acids are separated from the unbound nucleic acids and amplified by PCR._" ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "SELEX" ; obo:IAO_0000119 "PMID:21720957" ; a owl:Class ; rdfs:label "systematic evolution of ligands by exponential enrichment assay" ; rdfs:subClassOf obo:OBI_0001146 . obo:OBI_0002162 obo:IAO_0000111 "footprinting assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures ligand binding and conformational changes by the solvent accessibility of the backbone, bases, or side-chain structures of macromolecules through their sensitivity to chemical or enzymatic cleavage or modification reactions." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "doi:10.1002/3527600906.mcb.200300025" ; a owl:Class ; rdfs:label "footprinting assay" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0002163 obo:IAO_0000111 "DNAse footprinting assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzymatic footprinting assay that determines protein-binding sites on DNA by identifying bound fragments that are protected from DNAse I-catalyzed hydrolysis" ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000119 "OBI development call" ; a owl:Class ; rdfs:label "DNAse footprinting assay" ; rdfs:subClassOf obo:OBI_0002162 . obo:OBI_0002164 obo:IAO_0000111 "mammalian 2-hybrid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A binding assay that increases the expression of a reporter gene in mammalian cells by proteins of interest attached to two portions of the transcriptional activator, bringing those portions closer together." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000119 "ECO:0001095", "PMID:9043710" ; a owl:Class ; rdfs:label "mammalian 2-hybrid assay" ; rdfs:subClassOf obo:OBI_0001146 . obo:OBI_0002165 obo:IAO_0000111 "protein localization assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that determines the specific location of a protein. Subcellular localization is distinguished from tissue-based localization based on the type of microscopy applied." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000119 "OBI development call" ; a owl:Class ; rdfs:label "protein localization assay" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0002166 obo:IAO_0000111 "tissue-based protein localization assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A protein localization assay that determines the specific location of a protein in a living tissue sample." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000119 "PMID:14686950" ; a owl:Class ; rdfs:label "tissue-based protein localization assay" ; rdfs:subClassOf obo:OBI_0002165 . obo:OBI_0002167 obo:IAO_0000111 "subcellular protein localization assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A protein localization assay that determines the specific subcellular location of a protein. The location is visualized through electron microscopy." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000119 "ECO" ; a owl:Class ; rdfs:label "subcellular protein localization assay" ; rdfs:subClassOf obo:OBI_0002165, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000990 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000990 ] ) ] . obo:OBI_0002168 obo:IAO_0000111 "subcellular protein immunohistochemistry assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An immunohistochemistry assay that uses antibodies to display the specific subcellular location of proteins." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000119 "ECO" ; a owl:Class ; rdfs:label "subcellular protein immunohistochemistry assay" ; rdfs:subClassOf obo:OBI_0001986 . obo:OBI_0002169 obo:IAO_0000111 "ChIP-qPCR assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A ChIP assay that uses quantitative PCR to determine levels of specific DNA in immunoprecipitated samples." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "PMID:18388953" ; a owl:Class ; rdfs:label "ChIP-qPCR assay" ; rdfs:subClassOf obo:OBI_0001954, obo:OBI_0002692, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000893 obo:OBI_0003368 ) ] ] . obo:OBI_0002170 obo:IAO_0000111 "genomic SELEX" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A systematic evolution of ligands by exponential enrichment assay that starts with a library derived from genomic DNA instead of synthetically derived random DNA molecules." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "PMID:20541015" ; a owl:Class ; rdfs:label "genomic SELEX" ; rdfs:subClassOf obo:OBI_0002161 . obo:OBI_0002171 obo:IAO_0000111 "dot blot assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that detects molecules in a mixture dotted on a membrane using DNA probes or antibodies." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000118 "dot blot analysis" ; obo:IAO_0000119 "PMID:10473518" ; a owl:Class ; rdfs:label "dot blot assay" ; rdfs:subClassOf obo:OBI_0000443 . obo:OBI_0002172 obo:IAO_0000111 "Northwestern blot assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A direct binding assay that detects interactions of labeled RNA with immobilized protein on a membrane." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000118 "Northwestern analysis", "Northwestern assay" ; obo:IAO_0000119 "PMID:26965261" ; a owl:Class ; rdfs:label "Northwestern blot assay" ; rdfs:subClassOf obo:OBI_0001591 . obo:OBI_0002173 obo:IAO_0000111 "Southwestern blot assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A direct binding assay that detects interactions of labeled DNA with immobilized protein on a membrane." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "PMID:26404144" ; a owl:Class ; rdfs:label "Southwestern blot assay" ; rdfs:subClassOf obo:OBI_0001591 . obo:OBI_0002174 obo:IAO_0000111 "immunocytochemistry" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An immuno staining assay in which samples of intact cells are examined that have had most, if not all, of their surrounding extracellular matrix removed" ; obo:IAO_0000117 "Bjoern Peters" ; a owl:Class ; rdfs:label "immunocytochemistry" ; rdfs:subClassOf obo:OBI_0001632, obo:OBI_0001977, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:CL_0000000 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0002175 obo:IAO_0000111 "ATP bioluminescence assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that detects ATP concentration through light intensity when luciferase catalyzes the oxidation of luciferin in the presence of ATP, magnesium ions, and molecular oxygen." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "ATP quantitation assay", "cell viability ATP quantitation assay" ; obo:IAO_0000119 "ECO" ; a owl:Class ; rdfs:label "ATP bioluminescence assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_15422 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_15422 ] ) ] . obo:OBI_0002176 obo:IAO_0000111 "electrophysiology assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures the electrical properties of biological cells or tissues. Typically, this assay will generate measurements of voltage changes or electric current (or other associated variables such as impedence or capacitance)." ; obo:IAO_0000116 "Note that electrophysiological manipulations also exist which involve processes that alter the electrophysiological properties of cells and tissues." ; obo:IAO_0000117 "Gully Burns" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Electrophysiology" ; a owl:Class ; rdfs:label "electrophysiology assay" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0002177 obo:IAO_0000111 "patch clamp assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An intracellular electrophysiology assay where a glass micropipette is sealed to the surface of the cell membrane as a recording electrode to study ion channel activity. The key distinction of this technique is the electrical resistance of the seal between the cell membrane and the pipette is of the order 10-100 gigaohms, permitting high-resolution current measurements over the cell membrane in several different standard configurations." ; obo:IAO_0000117 "Gully Burns" ; obo:IAO_0000119 "ECO:0006012", "url:http://www.annualreviews.org/doi/pdf/10.1146/annurev.ph.46.030184.002323", "url:https://en.wikipedia.org/wiki/Patch_clamp" ; a owl:Class ; rdfs:label "patch clamp assay" ; rdfs:subClassOf obo:OBI_0000447, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001080 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001080 ] ) ] . obo:OBI_0002178 obo:IAO_0000111 "whole-cell patch clamp assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A patch-clamp assay where the electrode is left in place on the cell, as in cell-attached recordings, but the membrane patch has been perforated, providing access from the interior of the pipette to the intracellular space of the cell. Measurements made with this technique involve recording currents through multiple channels simultaneously, over the membrane of the entire cell." ; obo:IAO_0000117 "Gully Burns" ; obo:IAO_0000119 "ECO:0006015", "url:https://en.wikipedia.org/wiki/Patch_clamp#Whole-cell_recording_or_whole-cell_patch" ; a owl:Class ; rdfs:label "whole-cell patch clamp assay" ; rdfs:subClassOf obo:OBI_0002177, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001080 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001080 ] ) ] . obo:OBI_0002179 obo:IAO_0000111 "cell-attached patch clamp assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A patch-clamp assay where the electrode is left in place on the cell, and the membrane patch has been left intact been perforated. This maintains the separation of the interior of the pipette to the intracellular space of the cell. Measurements made with this technique involve recording currents through multiple channels simultaneously, over the membrane of the entire cell." ; obo:IAO_0000117 "Gully Burns" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Patch_clamp#Cell-attached_patch" ; a owl:Class ; rdfs:label "cell-attached patch clamp assay" ; rdfs:subClassOf obo:OBI_0002177, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001080 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001080 ] ) ] . obo:OBI_0002180 obo:IAO_0000111 "inside-out patch clamp assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A patch-clamp assay where a patch of the membrane is attached to the patch pipette, detached from the rest of the cell, and the cytosolic surface of the membrane is exposed to the external media, or bath. This provides the experimenter has access to the intracellular surface of the membrane via the bath and can manipulate the environment at the intracellular surface of single ion channels. For example, channels that are activated by intracellular ligands can then be studied through a range of ligand concentrations." ; obo:IAO_0000117 "Gully Burns" ; obo:IAO_0000119 "url:http://www.leica-microsystems.com/science-lab/the-patch-clamp-technique/", "url:https://en.wikipedia.org/wiki/Patch_clamp#Inside-out_patch" ; a owl:Class ; rdfs:label "inside-out patch clamp assay" ; rdfs:subClassOf obo:OBI_0002177, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001080 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001080 ] ) ] . obo:OBI_0002181 obo:IAO_0000111 "outside-out patch clamp assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A patch-clamp assay where a patch of the membrane is attached to the patch pipette. In this configuration, the external surface of the cell membrane is exposed as the outside of the membrane patch relative to the patch electrode. An outside-out patch starts with a gigaohm seal in a whole-cell recording configuration. The electrode is slowly withdrawn from the cell, until a fragment of membrane bulges away from the cell, which detaches and reforms as a convex membrane on the end of the electrode, with the original external surface of the membrane facing outward from the electrode. This provides the experimenter with access to the extracellular surface of the membrane via the bath and can manipulate the environment at the extracellular surface of single ion channels." ; obo:IAO_0000117 "Gully Burns" ; obo:IAO_0000119 "url:http://www.leica-microsystems.com/science-lab/the-patch-clamp-technique/", "url:https://en.wikipedia.org/wiki/Patch_clamp#Outside-out_patch" ; a owl:Class ; rdfs:label "outside-out patch clamp assay" ; rdfs:subClassOf obo:OBI_0002177, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001080 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001080 ] ) ] . obo:OBI_0002182 obo:IAO_0000111 "voltage clamp assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An cellular electrophysiology assay where the membrane potential of a cell is controlled by the experimentalist. This is accomplished through a feedback mechanism where any change in membrane potential is countered by permitting electrical current to flow into or out of the cell." ; obo:IAO_0000117 "Gully Burns" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Voltage_clamp" ; a owl:Class ; rdfs:label "voltage clamp assay" ; rdfs:subClassOf obo:OBI_0000447, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001129 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001129 ] ) ] . obo:OBI_0002183 obo:IAO_0000111 "two electrode voltage clamp assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The two electrode voltage clamp (TEVC) method utilizes two low-resistance pipettes, one sensing voltage and the other injecting current. The microelectrodes are filled with conductive solution and inserted into the cell to artificially control membrane potential. The membrane acts as a dielectric as well as a resistor, while the fluids on either side of the membrane function as capacitors.[9] The microelectrodes compare the membrane potential against a command voltage, giving an accurate reproduction of the currents flowing across the membrane. Current readings can be used to analyze the electrical response of the cell to different applications. This technique is mainly used in the Oocyte preparation." ; obo:IAO_0000117 "Gully Burns" ; obo:IAO_0000118 "TEVC" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Voltage_clamp#Two-electrode_voltage_clamp_using_microelectrodes" ; a owl:Class ; rdfs:label "two electrode voltage clamp assay" ; rdfs:subClassOf obo:OBI_0002182, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001129 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001129 ] ) ] . obo:OBI_0002184 obo:IAO_0000111 "cut open oocyte voltage clamp assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The cut-open oocyte Vaseline gap (COVG) voltage-clamp technique is designed to solve weaknesses in the two elextrode voltage clamp by maximizing the benefits of the Xenopus oocyte expression system by improving on clamp speed, signal-to-noise ratio, and ability to effectively perfuse the oocyte. In this way, it was possible to combine the most popular transient expression system, and the associated benefits of molecular cloning and site-directed mutagenesis, with the superior voltage-clamp properties of cut-open cell techniques." ; obo:IAO_0000117 "Gully Burns" ; obo:IAO_0000118 "COVG" ; obo:IAO_0000119 "PMID:9711615" ; a owl:Class ; rdfs:label "cut open oocyte voltage clamp assay" ; rdfs:subClassOf obo:OBI_0002182, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001129 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001129 ] ) ] . obo:OBI_0002185 obo:IAO_0000111 "current clamp assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The current clamp technique records the membrane potential by injecting current into a cell through the recording electrode. Unlike in the voltage clamp mode, where the membrane potential is held at a level determined by the experimenter, in \"current clamp\" mode the membrane potential is free to vary, and the amplifier records whatever voltage the cell generates on its own or as a result of stimulation. This technique is used to study how a cell responds when electric current enters a cell; this is important for instance for understanding how neurons respond to neurotransmitters that act by opening membrane ion channels." ; obo:IAO_0000117 "Gully Burns" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Electrophysiology#Current_clamp" ; a owl:Class ; rdfs:label "current clamp assay" ; rdfs:subClassOf obo:OBI_0000447 . obo:OBI_0002186 obo:IAO_0000111 "electroencephalography" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An extracellular electrophysiology assay where electrodes are mounted outside the brain (either on the surface of the scalp on onto the brain surface itself during surgery) to measure the electrical field over the external surface." ; obo:IAO_0000117 "Gully Burns" ; obo:IAO_0000118 "EEG" ; a owl:Class ; rdfs:label "electroencephalography" ; rdfs:subClassOf obo:OBI_0000454 . obo:OBI_0002187 obo:IAO_0000111 "single-unit recording" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An extracellular electrophysiology assay where a single microelectrode is placed in close proximity to a single neuron to measure voltage and current changes over time. This is the technicque used by Hubel and Wiesel to measure firing properties of primary visual cortex neurons in the 1950s in their original Nobel-prize winning study. A classic, old technique." ; obo:IAO_0000116 "Can be used on any cell, not just neurons." ; obo:IAO_0000117 "Gully Burns" ; obo:IAO_0000119 "url:http://www.thieme.com/media/samples/pubid-80418214.pdf" ; a owl:Class ; rdfs:label "single-unit recording" ; rdfs:subClassOf obo:OBI_0000454, obo:OBI_0001977, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000816 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000816 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:CL_0000540 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0001508 ] ] . obo:OBI_0002188 obo:IAO_0000111 "multi-unit recording" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An extracellular electrophysiology assay where a collection of microelectrodes (often in an 'array' configuration) is placed into neural tissue to measure the distribution of voltage and current changes for a population of cells over time." ; obo:IAO_0000117 "Gully Burns" ; a owl:Class ; rdfs:label "multi-unit recording" ; rdfs:subClassOf obo:OBI_0000454 . obo:OBI_0002189 obo:IAO_0000111 "local field potential recording" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An extracellular electrophysiology assay where a microelectrode is placed in the extracellular space of brain tissue to measure action potential and compared to an electrode either outside or inside that tissue." ; obo:IAO_0000117 "Gully Burns" ; obo:IAO_0000119 "doi:10.1007/978-1-4614-7320-6_723-1" ; a owl:Class ; rdfs:label "local field potential recording" ; rdfs:subClassOf obo:OBI_0000454, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000816 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000816 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0001508 ] ] . obo:OBI_0002190 obo:IAO_0000111 "courier organization" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An organization that delivers messages, packages, and mail." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "courier" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Courier" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "courier organization"@en ; rdfs:subClassOf obo:OBI_0000245, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000947 [ a owl:Restriction ; owl:onProperty obo:BFO_0000054 ; owl:someValuesFrom obo:OBI_0001580 ] ) ] ] . obo:OBI_0002191 obo:IAO_0000111 "courier tracking number" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A centrally registered identifier symbol assigned by a courier organization in order to track the delivery of an item." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "courier tracking number"@en ; rdfs:subClassOf obo:IAO_0000577 . obo:OBI_0002192 obo:IAO_0000111 "Leica Peloris rapid tissue processor" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An automatic tissue processor that is a dual retort tissue processor manufactured by the Leica company to provide fast, high quality tissue processing for histology laboratories." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "http://drp8p5tqcb2p5.cloudfront.net/fileadmin/downloads_lbs/Leica%20PELORIS/User%20Manuals/Leica_Peloris_manual_EN.pdf" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "Leica Peloris rapid tissue processor" ; rdfs:subClassOf obo:OBI_0001064 . obo:OBI_0002193 obo:IAO_0000111 "Thermo Fisher Scientific" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organization that is an American multinational, biotechnology product development company, created in 2006 by the merger of Thermo Electron and Fisher Scientific." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Thermo_Fisher_Scientific" ; a obo:OBI_0000245, owl:NamedIndividual ; rdfs:label "Thermo Fisher Scientific" . obo:OBI_0002194 obo:IAO_0000111 "Microm Ergostar HM200" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A microtome that is manufactured by Microm and uses a vertical cutting stroke common to all rotary microtomes engaged by a horizontal sliding movement. An operating arm replaces the handwheel and is attached to both sides of the instrument for greater convenience to permit control of sectioning from the left or right." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "http://www.ultra-medical.com/Microm-Ergostar-HM200-Microtome/en" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "Microm Ergostar HM200" ; rdfs:subClassOf obo:OBI_0400168 . obo:OBI_0002195 obo:IAO_0000111 "microtome blade" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A device that is the part of a microtome used to slice specimens to a desired thickness." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Microtome" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "microtome blade" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0002196 obo:IAO_0000111 "Sakura Low profile Accu-Edge microtome blade" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A microtome blade that is manufactured by Feather and is disposable. The ultra-sharp blades section specimens without striations, distortion or chattering." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "http://www.sakura.eu/Our-products/item/8/Microtomy/29/Accu-Edge-Disposable-Microtome-Blades" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "Sakura Low profile Accu-Edge microtome blade" ; rdfs:subClassOf obo:OBI_0002195 . obo:OBI_0002197 obo:IAO_0000111 "tissue section thickness" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A length measurement datum that is the result of an assay measuring the thickness of a tissue section." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "tissue section thickness"@en ; rdfs:subClassOf obo:IAO_0000408 . obo:OBI_0002198 obo:IAO_0000111 "molecular analysis facility organization" ; obo:IAO_0000112 "An analysis facility that includes analysis of molecular metabolites, as well as the various DNAs and RNAs." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An organization that provides molecular analysis service." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "MAF" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "molecular analysis facility organization"@en ; rdfs:subClassOf obo:OBI_0000245 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000245 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000947 [ a owl:Restriction ; owl:onProperty obo:BFO_0000054 ; owl:someValuesFrom obo:OBI_0001547 ] ) ] ] ) ] . obo:OBI_0002199 obo:IAO_0000111 "reason for lack of data item" ; obo:IAO_0000112 "cannot be assessed, not applicable, unknown" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An information content entity that provides an explanation why a data item is not provided." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "reason for lack of data item" ; rdfs:subClassOf obo:IAO_0000030 . obo:OBI_0002200 obo:IAO_0000111 "cannot be assessed determination" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A reason for lack of data item that is the negative output of a determination if assay will provide reliable results." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "cannot be assessed" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "cannot be assessed determination" ; rdfs:subClassOf obo:OBI_0002199 . obo:OBI_0002201 obo:IAO_0000111 "determination if assay will provide reliable results" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process that is used to assess whether an assay will provide reliable results based on the conditions or qualities of the inputs, devices, and other participants of the assay." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "determination if assay will provide reliable results" ; rdfs:subClassOf obo:OBI_0000011 . obo:OBI_0002202 obo:IAO_0000111 "GX" ; obo:IAO_0000112 "AJCC 7th edition GX: cannot be assessed." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cannot be assessed determination for histologic tumor grade." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "GX" ; rdfs:subClassOf obo:OBI_0002200 . obo:OBI_0002203 obo:IAO_0000111 "pTX" ; obo:IAO_0000112 "AJCC 7th edition pTX: cannot be assessed." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cannot be assessed determination for pathologic primary tumor staging." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "pTX" ; rdfs:subClassOf obo:OBI_0002200 . obo:OBI_0002204 obo:IAO_0000111 "pNX" ; obo:IAO_0000112 "AJCC 7th edition pNX: cannot be assessed." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cannot be assessed determination of pathologic staging of lymph nodes." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "pNX" ; rdfs:subClassOf obo:OBI_0002200 . obo:OBI_0002205 obo:IAO_0000111 "histologic grade according to AJCC 7th edition" ; obo:IAO_0000112 "G1:Well differentiated", "G4: Undifferentiated" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is a histologic grade assigned to a tumor slide specimen according to the American Joint Committee on Cancer (AJCC) 7th Edition grading system." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "histologic grade according to AJCC 7th edition" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002206 obo:IAO_0000111 "G1: Well differentiated" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A histologic grade according to AJCC 7th edition indicating that the tumor cells and the organization of the tumor tissue appear close to normal." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "G1" ; obo:IAO_0000119 "https://www.cancer.gov/about-cancer/diagnosis-staging/prognosis/tumor-grade-fact-sheet" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002205, owl:NamedIndividual ; rdfs:label "G1: Well differentiated" . obo:OBI_0002207 obo:IAO_0000111 "G2: Moderately differentiated" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A histologic grade according to AJCC 7th edition indicating that the tumor cells are moderately differentiated and reflect an intermediate grade." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "G2" ; obo:IAO_0000119 "https://www.cancer.gov/about-cancer/diagnosis-staging/prognosis/tumor-grade-fact-sheet" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002205, owl:NamedIndividual ; rdfs:label "G2: Moderately differentiated" . obo:OBI_0002208 obo:IAO_0000111 "G3: Poorly differentiated" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A histologic grade according to AJCC 7th edition indicating that the tumor cells are poorly differentiated and do not look like normal cells and tissue." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "G3" ; obo:IAO_0000119 "https://www.cancer.gov/about-cancer/diagnosis-staging/prognosis/tumor-grade-fact-sheet" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002205, owl:NamedIndividual ; rdfs:label "G3: Poorly differentiated" . obo:OBI_0002209 obo:IAO_0000111 "G4: Undifferentiated" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A histologic grade according to AJCC 7th edition indicating that the tumor cells are undifferentiated and do not look like normal cells and tissue." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "G4" ; obo:IAO_0000119 "https://www.cancer.gov/about-cancer/diagnosis-staging/prognosis/tumor-grade-fact-sheet" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002205, owl:NamedIndividual ; rdfs:label "G4: Undifferentiated" . obo:OBI_0002210 obo:IAO_0000111 "histologic grade according to the Fuhrman Nuclear Grading System" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is a histologic grade assigned to a tumor slide specimen according to the Fuhrman Nuclear Grading System." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Histologic Grade (Fuhrman Nuclear Grading System)" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "histologic grade according to the Fuhrman Nuclear Grading System" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002211 obo:IAO_0000111 "G1 (Fuhrman)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A histologic grade according to the Fuhrman Nuclear Grading System indicating that nuclei are round, uniform, approximately 10um and that nucleoli are inconspicuous or absent." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Grade 1" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002210, owl:NamedIndividual ; rdfs:label "G1 (Fuhrman)" . obo:OBI_0002212 obo:IAO_0000111 "G2 (Fuhrman)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A histologic grade according to the Fuhrman Nuclear Grading System indicating that nuclei are slightly irregular, approximately 15um and nucleoli are evident." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Grade 2" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002210, owl:NamedIndividual ; rdfs:label "G2 (Fuhrman)" . obo:OBI_0002213 obo:IAO_0000111 "G3 (Fuhrman)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A histologic grade according to the Fuhrman Nuclear Grading System indicating that nuclei are very irregular, approximately 20um and nucleoli large and prominent." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Grade 3" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002210, owl:NamedIndividual ; rdfs:label "G3 (Fuhrman)" . obo:OBI_0002214 obo:IAO_0000111 "G4 (Fuhrman)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A histologic grade according to the Fuhrman Nuclear Grading System indicating that nuclei arei bizarre and multilobulated, 20um or greater and nucleoli are prominent and chromatin clumped." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Grade 4" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002210, owl:NamedIndividual ; rdfs:label "G4 (Fuhrman)" . obo:OBI_0002215 obo:IAO_0000111 "histologic grade for ovarian tumor" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is a histologic grade assigned to a ovarian tumor." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "histologic grade for ovarian tumor" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002216 obo:IAO_0000111 "histologic grade for ovarian tumor according to a two-tier grading system" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A histologic grade for ovarian tumor that is from a two-tier histological classification of tumors." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "histologic grade for ovarian tumor according to a two-tier grading system" ; rdfs:subClassOf obo:OBI_0002215 . obo:OBI_0002217 obo:IAO_0000111 "Low grade ovarian tumor" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A histologic grade for ovarian tumor according to a two-tier grading system indicating that the tumor is low grade." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Low grade" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002216, owl:NamedIndividual ; rdfs:label "Low grade ovarian tumor" . obo:OBI_0002218 obo:IAO_0000111 "High grade ovarian tumor" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A histologic grade for ovarian tumor according to a two-tier grading system indicating that the tumor is high grade." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "High grade" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002216, owl:NamedIndividual ; rdfs:label "High grade ovarian tumor" . obo:OBI_0002219 obo:IAO_0000111 "histologic grade for ovarian tumor according to the World Health Organization" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A histologic grade for ovarian tumor that is from a histological classification by the World Health Organization (WHO)." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "histologic grade for ovarian tumor according to the World Health Organization" ; rdfs:subClassOf obo:OBI_0002215 . obo:OBI_0002220 obo:IAO_0000111 "G1 (WHO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A histologic grade for ovarian tumor according to the World Health Organization indicating that the tumor is well differentiated." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "G1" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002219, owl:NamedIndividual ; rdfs:label "G1 (WHO)" . obo:OBI_0002221 obo:IAO_0000111 "G2 (WHO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A histologic grade for ovarian tumor according to the World Health Organization indicating that the tumor is moderately differentiated." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "G2" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002219, owl:NamedIndividual ; rdfs:label "G2 (WHO)" . obo:OBI_0002222 obo:IAO_0000111 "G3 (WHO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A histologic grade for ovarian tumor according to the World Health Organization indicating that the tumor is poorly differentiated." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "G3" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002219, owl:NamedIndividual ; rdfs:label "G3 (WHO)" . obo:OBI_0002223 obo:IAO_0000111 "G4 (WHO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A histologic grade for ovarian tumor according to the World Health Organization indicating that the tumor is undifferentiated." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "G4" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002219, owl:NamedIndividual ; rdfs:label "G4 (WHO)" . obo:OBI_0002224 obo:IAO_0000111 "pathologic primary tumor stage for colon and rectum according to AJCC 7th edition" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is a pathologic finding about one or more characteristics of colorectal cancer following the rules of the TNM American Joint Committee on Cancer (AJCC) version 7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "pT: Pathologic spread colorectal primary tumor (AJCC 7th Edition)" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "pathologic primary tumor stage for colon and rectum according to AJCC 7th edition" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002225 obo:IAO_0000111 "pT0 (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that there is no evidence of primary tumor." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002224, owl:NamedIndividual ; rdfs:label "pT0 (colon)" . obo:OBI_0002226 obo:IAO_0000111 "pTis (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating carcinoma in situ (intraepithelial or invasion of lamina propria)." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002224, owl:NamedIndividual ; rdfs:label "pTis (colon)" . obo:OBI_0002227 obo:IAO_0000111 "pT1 (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that the tumor invades submucosa." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002224, owl:NamedIndividual ; rdfs:label "pT1 (colon)" . obo:OBI_0002228 obo:IAO_0000111 "pT2 (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that the tumor invades muscularis propria." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002224, owl:NamedIndividual ; rdfs:label "pT2 (colon)" . obo:OBI_0002229 obo:IAO_0000111 "pT3 (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that the tumor invades subserosa or into non-peritionealized pericolic or perirectal tissues." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002224, owl:NamedIndividual ; rdfs:label "pT3 (colon)" . obo:OBI_0002230 obo:IAO_0000111 "pT4a (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that the tumor perforates visceral peritoneum." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002224, owl:NamedIndividual ; rdfs:label "pT4a (colon)" . obo:OBI_0002231 obo:IAO_0000111 "pT4b (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that the tumor directly invades other organs or structures." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002224, owl:NamedIndividual ; rdfs:label "pT4b (colon)" . obo:OBI_0002232 obo:IAO_0000111 "pathologic primary tumor stage for lung according to AJCC 7th edition" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM American Joint Committee on Cancer (AJCC) version 7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "pT: Pathologic spread lung primary tumor (AJCC 7th Edition)" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "pathologic primary tumor stage for lung according to AJCC 7th edition" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002233 obo:IAO_0000111 "pT0 (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that there is no evidence of primary tumor." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002232, owl:NamedIndividual ; rdfs:label "pT0 (lung)" . obo:OBI_0002234 obo:IAO_0000111 "pTis (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating carcinoma in situ." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002232, owl:NamedIndividual ; rdfs:label "pTis (lung)" . obo:OBI_0002235 obo:IAO_0000111 "pT1 (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus)." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002232, owl:NamedIndividual ; rdfs:label "pT1 (lung)" . obo:OBI_0002236 obo:IAO_0000111 "pT1a (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is 2 cm or less in greatest dimension." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002232, owl:NamedIndividual ; rdfs:label "pT1a (lung)" . obo:OBI_0002237 obo:IAO_0000111 "pT1b (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is more than 2 cm but not more than 3 cm in greatest dimension." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002232, owl:NamedIndividual ; rdfs:label "pT1b (lung)" . obo:OBI_0002238 obo:IAO_0000111 "pT2 (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is more than 3 cm but not more than 7 cm or the tumor has any of the following features: involves main bronchus, 2 cm or more distal to the carina, invades visceral pleura, associated with atelectasis or obstructive pneumonitis that extends to the hilar region but does not involve the entire lung." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002232, owl:NamedIndividual ; rdfs:label "pT2 (lung)" . obo:OBI_0002239 obo:IAO_0000111 "pT2a (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is more than 3 cm but not more than 5 cm in greatest dimension." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002232, owl:NamedIndividual ; rdfs:label "pT2a (lung)" . obo:OBI_0002240 obo:IAO_0000111 "pT2b (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is more than 5 cm but not more than 7 cm in greatest dimension." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002232, owl:NamedIndividual ; rdfs:label "pT2b (lung)" . obo:OBI_0002241 obo:IAO_0000111 "pT3 (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is more than 7 cm or one that directly invades any of: parietal pleura, chest wall (including superior sulcus tumors), diaphragm, phrenic nerve, mediastinal pleura, parietal pericardiu or the tumor is in the main bronchus less than 2 cm distal to the carina but without involvement of the carina or there is associated atelectasis or obstructive pneumonitis of the entire lung or there is separate tumor nodule(s) in the same lobe as the primary." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002232, owl:NamedIndividual ; rdfs:label "pT3 (lung)" . obo:OBI_0002242 obo:IAO_0000111 "pT4 (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, carina or there is separate tumor nodule(s) in a different ipsilateral lobe to that of the primary." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002232, owl:NamedIndividual ; rdfs:label "pT4 (lung)" . obo:OBI_0002243 obo:IAO_0000111 "pathologic primary tumor stage for kidney according to AJCC 7th edition" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "pT: Pathologic spread kidney primary tumor (AJCC 7th Edition)" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "pathologic primary tumor stage for kidney according to AJCC 7th edition" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002244 obo:IAO_0000111 "pT0 (kidney)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that there is no evidence of primary tumor." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/kidney_parenchyma/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002243, owl:NamedIndividual ; rdfs:label "pT0 (kidney)" . obo:OBI_0002245 obo:IAO_0000111 "pT1 (kidney)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is 7 cm or less in greatest dimension and limited to the kidney." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/kidney_parenchyma/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002243, owl:NamedIndividual ; rdfs:label "pT1 (kidney)" . obo:OBI_0002246 obo:IAO_0000111 "pT1a (kidney)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is 4 cm or less." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/kidney_parenchyma/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002243, owl:NamedIndividual ; rdfs:label "pT1a (kidney)" . obo:OBI_0002247 obo:IAO_0000111 "pT1b (kidney)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is more than 4 cm but not more than 7 cm." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/kidney_parenchyma/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002243, owl:NamedIndividual ; rdfs:label "pT1b (kidney)" . obo:OBI_0002248 obo:IAO_0000111 "pT2 (kidney)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is more than 7 cm in greatest dimension and limited to the kidney." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/kidney_parenchyma/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002243, owl:NamedIndividual ; rdfs:label "pT2 (kidney)" . obo:OBI_0002249 obo:IAO_0000111 "pT2a (kidney)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is more than 7 cm but not more than 10 cm." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/kidney_parenchyma/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002243, owl:NamedIndividual ; rdfs:label "pT2a (kidney)" . obo:OBI_0002250 obo:IAO_0000111 "pT2b (kidney)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is more than 10 cm and limited to the kidney." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/kidney_parenchyma/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002243, owl:NamedIndividual ; rdfs:label "pT2b (kidney)" . obo:OBI_0002251 obo:IAO_0000111 "pT3 (kidney)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor extends into major veins or perinephric tissues but not into the ipsilateral adrenal gland and not beyond the Gerota fascia." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/kidney_parenchyma/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002243, owl:NamedIndividual ; rdfs:label "pT3 (kidney)" . obo:OBI_0002252 obo:IAO_0000111 "pT3a (kidney)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor grossly extends into the renal vein or its segmental (muscle containing) branches, or the tumor invades perirenal and/or renal sinus fat (peripelvic) fat but not beyond Gerota fascia." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/kidney_parenchyma/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002243, owl:NamedIndividual ; rdfs:label "pT3a (kidney)" . obo:OBI_0002253 obo:IAO_0000111 "pT3b (kidney)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor grossly extends into vena cava below diaphragm." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/kidney_parenchyma/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002243, owl:NamedIndividual ; rdfs:label "pT3b (kidney)" . obo:OBI_0002254 obo:IAO_0000111 "pT3c (kidney)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor grossly extends into vena cava above the diaphragm or Invades the wall of the vena cava." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/kidney_parenchyma/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002243, owl:NamedIndividual ; rdfs:label "pT3c (kidney)" . obo:OBI_0002255 obo:IAO_0000111 "pT4 (kidney)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor invades beyond Gerota fascia (including contiguous extension into the ipsilateral adrenal gland)." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/kidney_parenchyma/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002243, owl:NamedIndividual ; rdfs:label "pT4 (kidney)" . obo:OBI_0002256 obo:IAO_0000111 "pathologic primary tumor stage for ovary according to AJCC 7th edition" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "pT: Pathologic spread ovarian primary tumor (AJCC 7th Edition)" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "pathologic primary tumor stage for ovary according to AJCC 7th edition" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002257 obo:IAO_0000111 "pT0 (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that there is no evidence of primary tumor." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002256, owl:NamedIndividual ; rdfs:label "pT0 (ovary)" . obo:OBI_0002258 obo:IAO_0000111 "pT1 (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor is limited to the ovaries (one or both)." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002256, owl:NamedIndividual ; rdfs:label "pT1 (ovary)" . obo:OBI_0002259 obo:IAO_0000111 "pT1a (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor is limited to one ovary; capsule intact, no tumor on ovarian surface and no malignant cells in ascites or peritoneal washings." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002256, owl:NamedIndividual ; rdfs:label "pT1a (ovary)" . obo:OBI_0002260 obo:IAO_0000111 "pT1b (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor is limited to both ovaries; capsule intact, no tumor on ovarian surface and no malignant cells in ascites or peritoneal washings." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002256, owl:NamedIndividual ; rdfs:label "pT1b (ovary)" . obo:OBI_0002261 obo:IAO_0000111 "pT1c (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor is limited to one or both ovaries with capsule ruptured, tumor on ovarian surface, or malignant cells in ascites or peritoneal washings." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002256, owl:NamedIndividual ; rdfs:label "pT1c (ovary)" . obo:OBI_0002262 obo:IAO_0000111 "pT2 (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor involves one or both ovaries with pelvic extension." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002256, owl:NamedIndividual ; rdfs:label "pT2 (ovary)" . obo:OBI_0002263 obo:IAO_0000111 "pT2a (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has extension and/or implants on uterus and/or tube(s) and no malignant cells in ascites or peritoneal washings." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002256, owl:NamedIndividual ; rdfs:label "pT2a (ovary)" . obo:OBI_0002264 obo:IAO_0000111 "pT2b (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has extension to other pelvic tissues and no malignant cells in ascites or peritoneal washings." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002256, owl:NamedIndividual ; rdfs:label "pT2b (ovary)" . obo:OBI_0002265 obo:IAO_0000111 "pT2c (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has pelvic extension with malignant cells in ascites or peritoneal washings." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002256, owl:NamedIndividual ; rdfs:label "pT2c (ovary)" . obo:OBI_0002266 obo:IAO_0000111 "pT3 (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis and/or regional lymph node metastasis." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002256, owl:NamedIndividual ; rdfs:label "pT3 (ovary)" . obo:OBI_0002267 obo:IAO_0000111 "pT3a (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has microscopic peritoneal metastasis beyond pelvis." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002256, owl:NamedIndividual ; rdfs:label "pT3a (ovary)" . obo:OBI_0002268 obo:IAO_0000111 "pT3b (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has macroscopic peritoneal, metastatasis beyond pelvis, 2 cm or less in greatest dimension." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002256, owl:NamedIndividual ; rdfs:label "pT3b (ovary)" . obo:OBI_0002269 obo:IAO_0000111 "pT3c (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has peritoneal metastasis beyond pelvis, more than 2 cm in greatest dimension and/or regional lymph node metastasis." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_t/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002256, owl:NamedIndividual ; rdfs:label "pT3c (ovary)" . obo:OBI_0002270 obo:IAO_0000111 "pathologic lymph node stage for colon and rectum according to AJCC 7th edition" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is a pathologic finding about one or more characteristics of colorectal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "pN: Pathologic spread colon lymph nodes (AJCC 7th Edition)" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "pathologic lymph node stage for colon and rectum according to AJCC 7th edition" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002271 obo:IAO_0000111 "pN0 (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating no regional lymph node metastsis." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_n/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002270, owl:NamedIndividual ; rdfs:label "pN0 (colon)" . obo:OBI_0002272 obo:IAO_0000111 "pN1 (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 1-3 regional lymph nodes." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_n/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002270, owl:NamedIndividual ; rdfs:label "pN1 (colon)" . obo:OBI_0002273 obo:IAO_0000111 "pN1a (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 1 regional lymph node." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_n/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002270, owl:NamedIndividual ; rdfs:label "pN1a (colon)" . obo:OBI_0002274 obo:IAO_0000111 "pN1b (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 2-3 regional lymph nodes." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_n/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002270, owl:NamedIndividual ; rdfs:label "pN1b (colon)" . obo:OBI_0002275 obo:IAO_0000111 "pN1c (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating tumor deposit(s), i.e., satellites in the subserosa, or in non-peritonealized pericolic or perirectal soft tissue without regional lymph node metastasis." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_n/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002270, owl:NamedIndividual ; rdfs:label "pN1c (colon)" . obo:OBI_0002276 obo:IAO_0000111 "pN2 (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 4 or more regional lymph nodes." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_n/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002270, owl:NamedIndividual ; rdfs:label "pN2 (colon)" . obo:OBI_0002277 obo:IAO_0000111 "pN2a (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 4 to 6 regional lymph nodes." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_n/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002270, owl:NamedIndividual ; rdfs:label "pN2a (colon)" . obo:OBI_0002278 obo:IAO_0000111 "pN2b (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 7 or more regional lymph nodes." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_n/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002270, owl:NamedIndividual ; rdfs:label "pN2b (colon)" . obo:OBI_0002279 obo:IAO_0000111 "pathologic lymph node stage for lung according to AJCC 7th edition" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "pN: Pathologic spread colon lymph nodes (AJCC 7th Edition)" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "pathologic lymph node stage for lung according to AJCC 7th edition" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002280 obo:IAO_0000111 "pN0 (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic lymph node stage for lung according to AJCC 7th edition indicating no regional lymph node metastasis." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_n/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002279, owl:NamedIndividual ; rdfs:label "pN0 (lung)" . obo:OBI_0002281 obo:IAO_0000111 "pN1 (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic lymph node stage for lung according to AJCC 7th edition indicating metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary nodes, including involvement by direct extension." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_n/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002279, owl:NamedIndividual ; rdfs:label "pN1 (lung)" . obo:OBI_0002282 obo:IAO_0000111 "pN2 (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic lymph node stage for lung according to AJCC 7th edition indicating metastasis in ipsilateral mediastinal and/or subcarinal lymph node(s)." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_n/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002279, owl:NamedIndividual ; rdfs:label "pN2 (lung)" . obo:OBI_0002283 obo:IAO_0000111 "pN3 (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic lymph node stage for lung according to AJCC 7th edition indicating metastasis in contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph node(s)." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_n/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002279, owl:NamedIndividual ; rdfs:label "pN3 (lung)" . obo:OBI_0002284 obo:IAO_0000111 "pathologic lymph node stage for kidney according to AJCC 7th edition" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "pN: Pathologic spread kidney lymph nodes (AJCC 7th Edition)" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "pathologic lymph node stage for kidney according to AJCC 7th edition" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002285 obo:IAO_0000111 "pN0 (kidney)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic lymph node stage for kidney according to AJCC 7th edition indicating that there is no regional lymph node metastasis." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/kidney_parenchyma/path_n/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002284, owl:NamedIndividual ; rdfs:label "pN0 (kidney)" . obo:OBI_0002286 obo:IAO_0000111 "pN1 (kidney)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic lymph node stage for kidney according to AJCC 7th edition indicating that there is regional lymph node metastasis." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/kidney_parenchyma/path_n/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002284, owl:NamedIndividual ; rdfs:label "pN1 (kidney)" . obo:OBI_0002287 obo:IAO_0000111 "pathologic lymph node stage for ovary according to AJCC 7th edition" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "pN: Pathologic spread ovarian lymph nodes (AJCC 7th Edition)" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "pathologic lymph node stage for ovary according to AJCC 7th edition" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002288 obo:IAO_0000111 "pN0 (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic lymph node stage for ovary according to AJCC 7th edition indicating that there is no regional lymph node metastasis." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_n/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002287, owl:NamedIndividual ; rdfs:label "pN0 (ovary)" . obo:OBI_0002289 obo:IAO_0000111 "pN1 (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic lymph node stage for ovary according to AJCC 7th edition indicating that there is regional lymph node metastasis." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_n/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002287, owl:NamedIndividual ; rdfs:label "pN1 (ovary)" . obo:OBI_0002290 obo:IAO_0000111 "pathologic distant metastases stage for colon according to AJCC 7th edition" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is a pathologic finding about one or more characteristics of colon cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "M: colon distant metastases (AJCC 7th Edition)" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "pathologic distant metastases stage for colon according to AJCC 7th edition" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002291 obo:IAO_0000111 "cM0 (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that there are no symptoms or signs of distant metastasis." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cancer_staging#Pathological_M_Categorization_.28cM_and_pM.29" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002290, owl:NamedIndividual ; rdfs:label "cM0 (colon)" . obo:OBI_0002292 obo:IAO_0000111 "cM1 (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that there is clinical evidence of distant metastases by history, physical examination, imaging studies, or invasive procedures, but without microscopic evidence of the presumed distant metastases." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cancer_staging#Pathological_M_Categorization_.28cM_and_pM.29" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002290, owl:NamedIndividual ; rdfs:label "cM1 (colon)" . obo:OBI_0002293 obo:IAO_0000111 "cM1a (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that metastasis is confined to one organ based on clinical assessment." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002290, owl:NamedIndividual ; rdfs:label "cM1a (colon)" . obo:OBI_0002294 obo:IAO_0000111 "cM1b (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that metastasis is in more than one organ or the peritoneum based on clinical assessment." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002290, owl:NamedIndividual ; rdfs:label "cM1b (colon)" . obo:OBI_0002295 obo:IAO_0000111 "pM1 (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that there is microscopic evidence confirming distant metastatic disease." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002290, owl:NamedIndividual ; rdfs:label "pM1 (colon)" . obo:OBI_0002296 obo:IAO_0000111 "pM1a (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that metastasis is confined to one organ and histologically confirmed." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002290, owl:NamedIndividual ; rdfs:label "pM1a (colon)" . obo:OBI_0002297 obo:IAO_0000111 "pM1b (colon)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that metastasis is in more than one organ or the peritoneum and histologically confirmed." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/colon/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002290, owl:NamedIndividual ; rdfs:label "pM1b (colon)" . obo:OBI_0002298 obo:IAO_0000111 "pathologic distant metastases stage for lung according to AJCC 7th edition" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "M: lung distant metastases (AJCC 7th Edition)" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "pathologic distant metastases stage for lung according to AJCC 7th edition" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002299 obo:IAO_0000111 "cM0 (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that there is no distant metastasis." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002298, owl:NamedIndividual ; rdfs:label "cM0 (lung)" . obo:OBI_0002300 obo:IAO_0000111 "cM1 (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that there are distant metastases based on clinical assessment." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002298, owl:NamedIndividual ; rdfs:label "cM1 (lung)" . obo:OBI_0002301 obo:IAO_0000111 "cM1a (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that metastasis is based on clinical assessment and a separate tumor nodule(s) in a contralateral lobe; tumor with pleural nodules OR malignant pleural or pericardial effusion." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002298, owl:NamedIndividual ; rdfs:label "cM1a (lung)" . obo:OBI_0002302 obo:IAO_0000111 "cM1b (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that there is a distant metastases based on clinical assessment." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002298, owl:NamedIndividual ; rdfs:label "cM1b (lung)" . obo:OBI_0002303 obo:IAO_0000111 "pM1 (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that there is a distant metastases that is histologically confirmed." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002298, owl:NamedIndividual ; rdfs:label "pM1 (lung)" . obo:OBI_0002304 obo:IAO_0000111 "pM1a (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that metastasis is histologically confirmed and a separate tumor nodule(s) in a contralateral lobe; tumor with pleural nodules OR malignant pleural or pericardial effusion." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002298, owl:NamedIndividual ; rdfs:label "pM1a (lung)" . obo:OBI_0002305 obo:IAO_0000111 "pM1b (lung)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that there is a distant metastases that is histologically confirmed and associated with distant lymph nodes or carcinomatosis." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/lung/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002298, owl:NamedIndividual ; rdfs:label "pM1b (lung)" . obo:OBI_0002306 obo:IAO_0000111 "pathologic distant metastases stage for kidney according to AJCC 7th edition" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "M: kidney distant Metastases (AJCC 7th Edition)" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "pathologic distant metastases stage for kidney according to AJCC 7th edition" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002307 obo:IAO_0000111 "cM0 (kidney)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for kidney according to AJCC 7th edition indicating that there is no distant metastasis." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/kidney_parenchyma/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002306, owl:NamedIndividual ; rdfs:label "cM0 (kidney)" . obo:OBI_0002308 obo:IAO_0000111 "cM1 (kidney)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for kidney according to AJCC 7th edition indicating that there are distant metastases based on clinical assessment." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/kidney_parenchyma/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002306, owl:NamedIndividual ; rdfs:label "cM1 (kidney)" . obo:OBI_0002309 obo:IAO_0000111 "pM1 (kidney)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for kidney according to AJCC 7th edition indicating that there is a distant metastases that is histologically confirmed." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/kidney_parenchyma/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002306, owl:NamedIndividual ; rdfs:label "pM1 (kidney)" . obo:OBI_0002310 obo:IAO_0000111 "pathologic distant metastases stage for ovary according to AJCC 7th edition" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "M: ovarian distant metastases (AJCC 7th Edition)" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "pathologic distant metastases stage for ovary according to AJCC 7th edition" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002311 obo:IAO_0000111 "cM0 (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for ovary according to AJCC 7th edition indicating that there is no distant metastasis." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002310, owl:NamedIndividual ; rdfs:label "cM0 (ovary)" . obo:OBI_0002312 obo:IAO_0000111 "cM1 (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for ovary according to AJCC 7th edition indicating that there is distant metastasis except peritoneal metastasis based on clinical assessment." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002310, owl:NamedIndividual ; rdfs:label "cM1 (ovary)" . obo:OBI_0002313 obo:IAO_0000111 "pM1 (ovary)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathologic distant metastases stage for ovary according to AJCC 7th edition indicating that there is distant metastasis except peritoneal metastasis that is histologically confirmed." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_m/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002310, owl:NamedIndividual ; rdfs:label "pM1 (ovary)" . obo:OBI_0002314 obo:IAO_0000111 "clinical tumor stage group according to AJCC 7th edition" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is an assessment of the stage of a cancer according to the American Joint Committee on Cancer (AJCC) v7 staging systems." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Clinical tumor stage group (AJCC 7th Edition)" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "clinical tumor stage group according to AJCC 7th edition" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002315 obo:IAO_0000111 "Occult Carcinoma (AJCC 7th)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical tumor stage group according to AJCC 7th edition indicating a small carcinoma, either asymptomatic or giving rise to metastases without symptoms due to the primary carcinoma." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Occult Carcinoma" ; obo:IAO_0000119 "http://www.medilexicon.com/dictionary/14371" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002314, owl:NamedIndividual ; rdfs:label "Occult Carcinoma (AJCC 7th)" . obo:OBI_0002316 obo:IAO_0000111 "Stage 0 (AJCC 7th)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical tumor stage group according to AJCC 7th edition indicating a carcinoma in situ (or melanoma in situ for melanoma of the skin or germ cell neoplasia in situ for testicular germ cell tumors) and generally is considered to have no metastatic potential." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage 0" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002314, owl:NamedIndividual ; rdfs:label "Stage 0 (AJCC 7th)" . obo:OBI_0002317 obo:IAO_0000111 "Stage I (AJCC 7th)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical tumor stage group according to AJCC 7th edition indicating cancers that are smaller or less deeply invasive without regional disease or nodes." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage I" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002314, owl:NamedIndividual ; rdfs:label "Stage I (AJCC 7th)" . obo:OBI_0002318 obo:IAO_0000111 "Stage IIA (AJCC 7th)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent but less than in Stage III and with differing characteristics from IIB and IIC." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IIA" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002314, owl:NamedIndividual ; rdfs:label "Stage IIA (AJCC 7th)" . obo:OBI_0002319 obo:IAO_0000111 "Stage IIB (AJCC 7th)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent but less than in Stage III and with differing characteristics from IIA and IIC." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IIB" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002314, owl:NamedIndividual ; rdfs:label "Stage IIB (AJCC 7th)" . obo:OBI_0002320 obo:IAO_0000111 "Stage IIC (AJCC 7th)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent but less than in Stage III and with differing characteristics from IIA and IIB." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IIC" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002314, owl:NamedIndividual ; rdfs:label "Stage IIC (AJCC 7th)" . obo:OBI_0002321 obo:IAO_0000111 "Stage IIIA (AJCC 7th)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent greater than in Stage II and with differing characteristics from IIIB and IIIC." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IIIA" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002314, owl:NamedIndividual ; rdfs:label "Stage IIIA (AJCC 7th)" . obo:OBI_0002322 obo:IAO_0000111 "Stage IIIB (AJCC 7th)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent greater than in Stage II and with differing characteristics from IIIA and IIIC." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IIIB" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002314, owl:NamedIndividual ; rdfs:label "Stage IIIB (AJCC 7th)" . obo:OBI_0002323 obo:IAO_0000111 "Stage IIIC (AJCC 7th)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent greater than in Stage II and with differing characteristics from IIIA and IIIB." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IIIC" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002314, owl:NamedIndividual ; rdfs:label "Stage IIIC (AJCC 7th)" . obo:OBI_0002324 obo:IAO_0000111 "Stage IVA (AJCC 7th)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical tumor stage group according to AJCC 7th edition indicating cancers in patients who present with distant metastases at diagnosis and with differing characteristics from IVB." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IVA" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002314, owl:NamedIndividual ; rdfs:label "Stage IVA (AJCC 7th)" . obo:OBI_0002325 obo:IAO_0000111 "Stage IVB (AJCC 7th)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical tumor stage group according to AJCC 7th edition indicating cancers in patients who present with distant metastases at diagnosis and with differing characteristics from IVA." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IVB" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002314, owl:NamedIndividual ; rdfs:label "Stage IVB (AJCC 7th)" . obo:OBI_0002326 obo:IAO_0000111 "International Federation of Gynecology and Obstetrics cervical cancer stage value specification" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is an assessment of the stage of a gynecologic cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging systems." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Clinical FIGO stage" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "International Federation of Gynecology and Obstetrics cervical cancer stage value specification" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002327 obo:IAO_0000111 "Stage IA (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating invasive carcinoma which can be diagnosed only by microscopy, with deepest invasion <5 mm and the largest extension <7 mm." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IA" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cervical_cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002326, owl:NamedIndividual ; rdfs:label "Stage IA (FIGO)" . obo:OBI_0002328 obo:IAO_0000111 "Stage IA1 (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating measured stromal invasion of <3.0 mm in depth and extension of <7.0 mm." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IA1" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cervical_cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002326, owl:NamedIndividual ; rdfs:label "Stage IA1 (FIGO)" . obo:OBI_0002329 obo:IAO_0000111 "Stage IA2 (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating measured stromal invasion of >3.0 mm and not >5.0 mm with an extension of not >7.0 mm." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IA2" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cervical_cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002326, owl:NamedIndividual ; rdfs:label "Stage IA2 (FIGO)" . obo:OBI_0002330 obo:IAO_0000111 "Stage IB (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating clinically visible lesions limited to the cervix uteri or pre-clinical cancers greater than stage IA" ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IB" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cervical_cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002326, owl:NamedIndividual ; rdfs:label "Stage IB (FIGO)" . obo:OBI_0002331 obo:IAO_0000111 "Stage IB1 (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating clinically visible lesion limited to the cervix uteri or pre-clinical cancers greater than stage IA <4.0 cm in greatest dimension." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IB1" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cervical_cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002326, owl:NamedIndividual ; rdfs:label "Stage IB1 (FIGO)" . obo:OBI_0002332 obo:IAO_0000111 "Stage IB2 (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating clinically visible lesion limited to the cervix uteri or pre-clinical cancers greater than stage IA >4.0 cm in greatest dimension." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IB2" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cervical_cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002326, owl:NamedIndividual ; rdfs:label "Stage IB2 (FIGO)" . obo:OBI_0002333 obo:IAO_0000111 "Stage IIA (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina without parametrial invasion." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IIA" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cervical_cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002326, owl:NamedIndividual ; rdfs:label "Stage IIA (FIGO)" . obo:OBI_0002334 obo:IAO_0000111 "Stage IIA1 (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina without parametrial invasion and clinically visible lesion <4.0 cm in greatest dimension." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IIA1" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cervical_cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002326, owl:NamedIndividual ; rdfs:label "Stage IIA1 (FIGO)" . obo:OBI_0002335 obo:IAO_0000111 "Stage IIA2 (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina without parametrial invasion and clinically visible lesion >4.0 cm in greatest dimension." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IIA2" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cervical_cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002326, owl:NamedIndividual ; rdfs:label "Stage IIA2 (FIGO)" . obo:OBI_0002336 obo:IAO_0000111 "Stage IIB (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina with obvious parametrial invasion." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IIB" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cervical_cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002326, owl:NamedIndividual ; rdfs:label "Stage IIB (FIGO)" . obo:OBI_0002337 obo:IAO_0000111 "Stage IIIA (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating tumour involves lower third of the vagina, with no extension to the pelvic wall." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IIIA" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cervical_cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002326, owl:NamedIndividual ; rdfs:label "Stage IIIA (FIGO)" . obo:OBI_0002338 obo:IAO_0000111 "Stage IIIB (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating extension to the pelvic wall and/or hydronephrosis or non-functioning kidney." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IIIB" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cervical_cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002326, owl:NamedIndividual ; rdfs:label "Stage IIIB (FIGO)" . obo:OBI_0002339 obo:IAO_0000111 "Stage IVA (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating spread of the growth to adjacent organs." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IVA" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cervical_cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002326, owl:NamedIndividual ; rdfs:label "Stage IVA (FIGO)" . obo:OBI_0002340 obo:IAO_0000111 "Stage IVB (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating spread to distant organs." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage IVB" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cervical_cancer_staging" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002326, owl:NamedIndividual ; rdfs:label "Stage IVB (FIGO)" . obo:OBI_0002341 obo:IAO_0000111 "International Federation of Gynecology and Obstetrics ovarian cancer stage value specification" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the FIGO classification system." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Pathologic Tumor Stage Grouping for ovarian cancer (FIGO)" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "International Federation of Gynecology and Obstetrics ovarian cancer stage value specification" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002342 obo:IAO_0000111 "Stage 1 (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T1, N0, and M0." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage 1" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_stage_group_direct/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002341, owl:NamedIndividual ; rdfs:label "Stage 1 (FIGO)" . obo:OBI_0002343 obo:IAO_0000111 "Stage 1A (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T1a, N0, and M0." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage 1A" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_stage_group_direct/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002341, owl:NamedIndividual ; rdfs:label "Stage 1A (FIGO)" . obo:OBI_0002344 obo:IAO_0000111 "Stage 1B (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T1b, N0, and M0." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage 1B" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_stage_group_direct/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002341, owl:NamedIndividual ; rdfs:label "Stage 1B (FIGO)" . obo:OBI_0002345 obo:IAO_0000111 "Stage 1C (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T1c, N0, and M0." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage 1C" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_stage_group_direct/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002341, owl:NamedIndividual ; rdfs:label "Stage 1C (FIGO)" . obo:OBI_0002346 obo:IAO_0000111 "Stage 2 (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T2, N0, and M0." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage 2" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_stage_group_direct/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002341, owl:NamedIndividual ; rdfs:label "Stage 2 (FIGO)" . obo:OBI_0002347 obo:IAO_0000111 "Stage 2A (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T2a, N0, and M0." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage 2A" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_stage_group_direct/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002341, owl:NamedIndividual ; rdfs:label "Stage 2A (FIGO)" . obo:OBI_0002348 obo:IAO_0000111 "Stage 2B (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T2b, N0, and M0." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage 2B" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_stage_group_direct/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002341, owl:NamedIndividual ; rdfs:label "Stage 2B (FIGO)" . obo:OBI_0002349 obo:IAO_0000111 "Stage 2C (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T2c, N0, and M0." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage 2C" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_stage_group_direct/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002341, owl:NamedIndividual ; rdfs:label "Stage 2C (FIGO)" . obo:OBI_0002350 obo:IAO_0000111 "Stage 3 (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of (T3, N0, and M0) or (T3,3a,3b, NX, and M0)." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage 3" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_stage_group_direct/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002341, owl:NamedIndividual ; rdfs:label "Stage 3 (FIGO)" . obo:OBI_0002351 obo:IAO_0000111 "Stage 3A (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T3a, N0, and M0 ." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage 3A" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_stage_group_direct/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002341, owl:NamedIndividual ; rdfs:label "Stage 3A (FIGO)" . obo:OBI_0002352 obo:IAO_0000111 "Stage 3B (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T3b, N0, and M0 ." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage 3B" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_stage_group_direct/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002341, owl:NamedIndividual ; rdfs:label "Stage 3B (FIGO)" . obo:OBI_0002353 obo:IAO_0000111 "Stage 3C (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of (T3c, N0,X and M0) or (any T, N1 and M0)." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage 3C" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_stage_group_direct/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002341, owl:NamedIndividual ; rdfs:label "Stage 3C (FIGO)" . obo:OBI_0002354 obo:IAO_0000111 "Stage 4 (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of any T, any N, and M1." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage 4" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_stage_group_direct/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002341, owl:NamedIndividual ; rdfs:label "Stage 4 (FIGO)" . obo:OBI_0002355 obo:IAO_0000111 "Stage Unknown (FIGO)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of (T0, N0, and M0) or (T1,1a-1c,2,2a-2c, NX, and M0) or (TX, N0,X, M0)." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Stage Unknown" ; obo:IAO_0000119 "https://staging.seer.cancer.gov/tnm/input/1.0/ovary/path_stage_group_direct/" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002341, owl:NamedIndividual ; rdfs:label "Stage Unknown (FIGO)" . obo:OBI_0002356 obo:IAO_0000111 "performance status value specification" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification that is an assessment of a participant's performance status (general well-being and activities of daily life)." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Performance Status Scale" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Performance_status" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "performance status value specification" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002357 obo:IAO_0000111 "Eastern Cooperative Oncology Group score value specification" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A performance status value specification designed by the Eastern Cooperative Oncology Group to assess disease progression and its affect on the daily living abilities of the patient." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "ECOG score" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "Eastern Cooperative Oncology Group score value specification" ; rdfs:subClassOf obo:OBI_0002356 . obo:OBI_0002358 obo:IAO_0000111 "3: symptomatic in bed more than 50% of the day but not bed ridden" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An Eastern Cooperative Oncology Group score value specification indicating a patient is symptomatic and in bed for more than 50% of the day but is not bed ridden." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002357, owl:NamedIndividual ; rdfs:label "3: symptomatic in bed more than 50% of the day but not bed ridden" . obo:OBI_0002359 obo:IAO_0000111 "2: symptomatic but in bed less than 50% of the day" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An Eastern Cooperative Oncology Group score value specification indicating a patient is symptomatic but is in bed for less than 50% of the day." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002357, owl:NamedIndividual ; rdfs:label "2: symptomatic but in bed less than 50% of the day" . obo:OBI_0002360 obo:IAO_0000111 "4: bed ridden" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An Eastern Cooperative Oncology Group score value specification indicating a patient is symptomatic and is bed ridden." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002357, owl:NamedIndividual ; rdfs:label "4: bed ridden" . obo:OBI_0002361 obo:IAO_0000111 "0: asymptomatic" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An Eastern Cooperative Oncology Group score value specification indicating a patient is asymptomatic." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002357, owl:NamedIndividual ; rdfs:label "0: asymptomatic" . obo:OBI_0002362 obo:IAO_0000111 "1: symptomatic but fully ambulatory" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An Eastern Cooperative Oncology Group score value specification indicating a patient is symptomatic but is fully ambulatory." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002357, owl:NamedIndividual ; rdfs:label "1: symptomatic but fully ambulatory" . obo:OBI_0002363 obo:IAO_0000111 "Karnofsky score vaue specification" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A performance status value specification designed for classifying patients 16 years of age or older by their functional impairment." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "Karnofsky Score" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "Karnofsky score vaue specification" ; rdfs:subClassOf obo:OBI_0002356 . obo:OBI_0002364 obo:IAO_0000111 "100: asymptomatic" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Karnofsky score vaue specification indicating that a patient is asymptomatic." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002363, owl:NamedIndividual ; rdfs:label "100: asymptomatic" . obo:OBI_0002365 obo:IAO_0000111 "80-90: symptomatic but fully ambulatory" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Karnofsky score vaue specification indicating that a patient is symptomatic but fully ambulatory." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002363, owl:NamedIndividual ; rdfs:label "80-90: symptomatic but fully ambulatory" . obo:OBI_0002366 obo:IAO_0000111 "60-70: symptomatic but in bed less than 50% of the day" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Karnofsky score vaue specification indicating that a patient is symptomatic but in bed less than 50% of the day." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002363, owl:NamedIndividual ; rdfs:label "60-70: symptomatic but in bed less than 50% of the day" . obo:OBI_0002367 obo:IAO_0000111 "40-50: symptomatic, in bed more than 50% of the day, but not bed ridden" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Karnofsky score vaue specification indicating that a patient is symptomatic, in bed more than 50% of the day, but not bed ridden." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBI" ; obo:IAO_0000234 "NCI BBRB" ; a obo:OBI_0002363, owl:NamedIndividual ; rdfs:label "40-50: symptomatic, in bed more than 50% of the day, but not bed ridden" . obo:OBI_0002368 obo:IAO_0000111 "clinical history of cancer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which there is a diagnosis of cancer." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "clinical history of cancer" ; rdfs:subClassOf obo:OGMS_0000015 . obo:OBI_0002369 obo:IAO_0000111 "clinical history devoid of cancer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which there was no diagnosis of cancer." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "clinical history of no cancer" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "clinical history devoid of cancer" ; rdfs:subClassOf obo:OGMS_0000015 . obo:OBI_0002370 obo:IAO_0000111 "unknown clinical history of cancer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which it is not known whether there was a diagnosis of cancer." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "unknown clinical history of cancer" ; rdfs:subClassOf obo:OGMS_0000015 . obo:OBI_0002371 obo:IAO_0000111 "diagnosis of cancer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A diagnosis that is an assertion that a patient who is the subject of a diagnostic process has cancer." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "cancer diagnosis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "diagnosis of cancer" ; rdfs:subClassOf obo:OGMS_0000073 . obo:OBI_0002372 obo:IAO_0000111 "family clinical history of cancer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which there is a diagnosis of cancer in a blood relative." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "family history of cancer" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "family clinical history of cancer" ; rdfs:subClassOf obo:OGMS_0000015 . obo:OBI_0002373 obo:IAO_0000111 "aunt clinical history of cancer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which there is a diagnosis of cancer in the female sibling of a parent." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "aunt clinical history of cancer" ; rdfs:subClassOf obo:OBI_0002372 . obo:OBI_0002374 obo:IAO_0000111 "brother clinical history of cancer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which there is a diagnosis of cancer in a male sibling." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "brother clinical history of cancer" ; rdfs:subClassOf obo:OBI_0002372 . obo:OBI_0002375 obo:IAO_0000111 "daughter clinical history of cancer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which there is a diagnosis of cancer in a person's female child." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "daughter clinical history of cancer" ; rdfs:subClassOf obo:OBI_0002372 . obo:OBI_0002376 obo:IAO_0000111 "father clinical history of cancer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which there is a diagnosis of cancer in a male parent." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "father clinical history of cancer" ; rdfs:subClassOf obo:OBI_0002372 . obo:OBI_0002377 obo:IAO_0000111 "mother clinical history of cancer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which there is a diagnosis of cancer in a female parent." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "mother clinical history of cancer" ; rdfs:subClassOf obo:OBI_0002372 . obo:OBI_0002378 obo:IAO_0000111 "sister clinical history of cancer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which there is a diagnosis of cancer in a female sibling." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "sister clinical history of cancer" ; rdfs:subClassOf obo:OBI_0002372 . obo:OBI_0002379 obo:IAO_0000111 "son clinical history of cancer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which there is a diagnosis of cancer in a person's male child." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "son clinical history of cancer" ; rdfs:subClassOf obo:OBI_0002372 . obo:OBI_0002380 obo:IAO_0000111 "uncle clinical history of cancer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which there is a diagnosis of cancer in a male sibling of a parent." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "uncle clinical history of cancer" ; rdfs:subClassOf obo:OBI_0002372 . obo:OBI_0002381 obo:IAO_0000111 "grandmother clinical history of cancer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which there is a diagnosis of cancer in a female parent of a parent." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "grandmother clinical history of cancer" ; rdfs:subClassOf obo:OBI_0002372 . obo:OBI_0002382 obo:IAO_0000111 "grandfather clinical history of cancer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which there is a diagnosis of cancer in a male parent of a parent." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "grandfather clinical history of cancer" ; rdfs:subClassOf obo:OBI_0002372 . obo:OBI_0002383 obo:IAO_0000111 "nephew clinical history of cancer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which there is a diagnosis of cancer in a male child of a sibling." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "nephew clinical history of cancer" ; rdfs:subClassOf obo:OBI_0002372 . obo:OBI_0002384 obo:IAO_0000111 "niece clinical history of cancer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which there is a diagnosis of cancer in a female child of a sibling." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "niece clinical history of cancer" ; rdfs:subClassOf obo:OBI_0002372 . obo:OBI_0002385 obo:IAO_0000111 "diagnosis of infectious disease" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A diagnosis that is an assertion that a patient who is the subject of a diagnostic process has an infectious disease." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "diagnosis of infectious disease" ; rdfs:subClassOf obo:OGMS_0000073 . obo:OBI_0002386 obo:IAO_0000111 "diagnosis of hepatitis B" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A diagnosis of infectious disease caused by the hepatitis B virus." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "diagnosis of hepatitis B" ; rdfs:subClassOf obo:OBI_0002385 . obo:OBI_0002387 obo:IAO_0000111 "diagnosis of hepatitis C" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A diagnosis of infectious disease caused by the hepatitis C virus." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "diagnosis of hepatitis C" ; rdfs:subClassOf obo:OBI_0002385 . obo:OBI_0002388 obo:IAO_0000111 "diagnosis of HIV" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A diagnosis of infectious disease caused by the human immunodeficiency virus (1 or 2)." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "diagnosis of HIV" ; rdfs:subClassOf obo:OBI_0002385 . obo:OBI_0002389 obo:IAO_0000111 "clinical history of repeated HIV assays" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which there is repeated reactive screening assays for human immunodeficiency virus (1 or 2) antibodies regardless of the results of supplemental assays." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "clinical history of repeated HIV assays" ; rdfs:subClassOf obo:OGMS_0000015 . obo:OBI_0002390 obo:IAO_0000111 "exposure to second hand smoke" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which there has been second hand exposure to tobacco smoking." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "exposure to second hand smoke" ; rdfs:subClassOf obo:OGMS_0000015 . obo:OBI_0002391 obo:IAO_0000111 "exposure to second hand smoke in household during childhood" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exposure to second hand smoke that occurred in the (patient's) household when the person was a child." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "exposure to second hand smoke in household during childhood" ; rdfs:subClassOf obo:OBI_0002390 . obo:OBI_0002392 obo:IAO_0000111 "exposure to second hand smoke in current household" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exposure to second hand smoke in person's current household." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "exposure to second hand smoke in current household" ; rdfs:subClassOf obo:OBI_0002390 . obo:OBI_0002393 obo:IAO_0000111 "pregnancy history" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which a female has had a pregnancy." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "pregnancy history" ; rdfs:subClassOf obo:OGMS_0000015 . obo:OBI_0002394 obo:IAO_0000111 "number of pregnancies" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A measurement datum of the total number of pregnancies a woman has had." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "number of pregnancies" ; rdfs:subClassOf obo:IAO_0000109 . obo:OBI_0002395 obo:IAO_0000111 "number of live births" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A measurement datum of the total number of live births a female has had." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "number of live births" ; rdfs:subClassOf obo:IAO_0000109 . obo:OBI_0002396 obo:IAO_0000111 "age when gave birth to first child" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An age measurement datum performed on a female when her first biological child was born." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "age when gave birth to first child" ; rdfs:subClassOf obo:OBI_0001167 . obo:OBI_0002397 obo:IAO_0000111 "gynecologic surgery history" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which a woman has had gynecologic surgery in the past." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "gynecologic surgery history" ; rdfs:subClassOf obo:OGMS_0000015 . obo:OBI_0002398 obo:IAO_0000111 "hysterectomy history" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A gynecologic surgery history in which a woman has had a hysterectomy." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "hysterectomy history" ; rdfs:subClassOf obo:OBI_0002397 . obo:OBI_0002399 obo:IAO_0000111 "unilateral oophorectomy history" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A gynecologic surgery history in which a woman has had a unilateral oophorectomy." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "unilateral oophorectomy history" ; rdfs:subClassOf obo:OBI_0002397 . obo:OBI_0002400 obo:IAO_0000111 "neither hysterectomy nor oophorectomy history" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A gynecologic surgery history in which a woman has not had either a hysterectomy or an oophorectomy." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "neither hysterectomy nor oophorectomy history" ; rdfs:subClassOf obo:OBI_0002397 . obo:OBI_0002401 obo:IAO_0000111 "hormonal birth control use history" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An information content entity that indicates whether a woman has ever used oral contraceptives in order to block ovulation and prevent the occurrence of pregnancy." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "hormonal birth control use history" ; rdfs:subClassOf obo:IAO_0000030 . obo:OBI_0002402 obo:IAO_0000111 "hormonal birth control former use history" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A hormonal birth control use history that indicates an individual has previously been a hormonal birth control user but is not a current user." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "hormonal birth control former use history" ; rdfs:subClassOf obo:OBI_0002401 . obo:OBI_0002403 obo:IAO_0000111 "hormonal birth control current use history" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A hormonal birth control use history that indicates an individual is currently a hormonal birth control user." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "hormonal birth control current use history" ; rdfs:subClassOf obo:OBI_0002401 . obo:OBI_0002404 obo:IAO_0000111 "no hormonal birth control use history" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A hormonal birth control use history that indicates an individual has not ever been a hormonal birth control user." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "no hormonal birth control use history" ; rdfs:subClassOf obo:OBI_0002401 . obo:OBI_0002405 obo:IAO_0000111 "hormonal replacement therapy history" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical history in which an individual has had hormonal replacement therapy in the past." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "hormonal replacement therapy history" ; rdfs:subClassOf obo:OGMS_0000015 . obo:OBI_0002406 obo:IAO_0000111 "delivery form for hormonal replacement therapy" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A processed material used for delivery of hormones in hormone replacement therapy." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "form of hormone replacement therapy" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "delivery form for hormonal replacement therapy" ; rdfs:subClassOf obo:OBI_0000047 . obo:OBI_0002407 obo:IAO_0000111 "pill delivery form for hormonal replacement therapy" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A delivery form for hormonal replacement therapy that is a pill for oral administration." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "pill delivery form for hormonal replacement therapy" ; rdfs:subClassOf obo:OBI_0002406 . obo:OBI_0002408 obo:IAO_0000111 "patch delivery form for hormonal replacement therapy" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A delivery form for hormonal replacement therapy that is a patch for transdermal administration." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "patch delivery form for hormonal replacement therapy" ; rdfs:subClassOf obo:OBI_0002406 . obo:OBI_0002409 obo:IAO_0000111 "cream delivery form for hormonal replacement therapy" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A delivery form for hormonal replacement therapy that is a cream for transdermal administration." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "cream delivery form for hormonal replacement therapy" ; rdfs:subClassOf obo:OBI_0002406 . obo:OBI_0002410 obo:IAO_0000111 "menopausal status" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An information content entity that indicates the state of a female's cessation of menstruation." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "menopausal status" ; rdfs:subClassOf obo:IAO_0000030 . obo:OBI_0002411 obo:IAO_0000111 "indeterminate menopausal status" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A menopausal status that is neither pre- nor post-menopausal." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "indeterminate menopausal status" ; rdfs:subClassOf obo:OBI_0002410 . obo:OBI_0002412 obo:IAO_0000111 "premenopausal status" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A menopausal status indicating that less than 6 months has passed since the last menstrual period and there has not been prior bilateral oophorectomy and not on estrogen replacement." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "premenopausal status" ; rdfs:subClassOf obo:OBI_0002410 . obo:OBI_0002413 obo:IAO_0000111 "perimenopausal status" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A menopausal status indicating that it has been 6-12 months since last menstrual period." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "perimenopausal status" ; rdfs:subClassOf obo:OBI_0002410 . obo:OBI_0002414 obo:IAO_0000111 "postmenopausal status" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A menopausal status indicating that it has been more than 12 months since the last menstrual period with no prior hysterectomy or that there has been a prior bilateral oophorectomy." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "postmenopausal status" ; rdfs:subClassOf obo:OBI_0002410 . obo:OBI_0002415 obo:IAO_0000111 "exposure to environmental and workplace carcinogens history" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An information content entity that indicates the exposure of an individual to carcinogens in the workplace or environment." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "exposure to environmental and workplace carcinogens history" ; rdfs:subClassOf obo:IAO_0000030 . obo:OBI_0002416 obo:IAO_0000111 "exposure to arsenic history" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exposure to environmental and workplace carcinogens history where the carcinogen is arsenic." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "exposure to arsenic history" ; rdfs:subClassOf obo:OBI_0002415 . obo:OBI_0002417 obo:IAO_0000111 "exposure to asbestos history" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exposure to environmental and workplace carcinogens history where the carcinogen is asbestos." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "exposure to asbestos history" ; rdfs:subClassOf obo:OBI_0002415 . obo:OBI_0002418 obo:IAO_0000111 "exposure to diesel exhaust history" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exposure to environmental and workplace carcinogens history where the carcinogen is diesel exhaust." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "exposure to diesel exhaust history" ; rdfs:subClassOf obo:OBI_0002415 . obo:OBI_0002419 obo:IAO_0000111 "exposure to chromium history" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exposure to environmental and workplace carcinogens history where the carcinogen is chromium." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "exposure to chromium history" ; rdfs:subClassOf obo:OBI_0002415 . obo:OBI_0002420 obo:IAO_0000111 "exposure to silica history" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exposure to environmental and workplace carcinogens history where the carcinogen is silica." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "exposure to silica history" ; rdfs:subClassOf obo:OBI_0002415 . obo:OBI_0002421 obo:IAO_0000111 "indicator of whether an inclusion criterion was met" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An information content entity that indicates whether or not an entity has met a specific requirement in order to take part in a given process." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "eligibility criterion met" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "indicator of whether an inclusion criterion was met" ; rdfs:subClassOf obo:IAO_0000030 . obo:OBI_0002422 obo:IAO_0000111 "indicator of whether all inclusion criteria were met" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An information content entity that indicates whether or not an entity has met all specific requirements in order to take part in a given process." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000118 "all eligibility criteria met" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "indicator of whether all inclusion criteria were met" ; rdfs:subClassOf obo:IAO_0000030 . obo:OBI_0002423 obo:IAO_0000111 "age of majority inclusion criterion" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An inclusion criterion that uses the age of majority for a state or institution, where one is generally considered to be an adult, which if met, makes an individual suitable for a given task or participation in a given process." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "age of majority inclusion criterion" ; rdfs:subClassOf obo:OBI_0500027 . obo:OBI_0002424 obo:IAO_0000111 "chemotherapy treatment exclusion criterion" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exclusion criterion that defines whether chemotherapy was received or is being received for a previous or current cancer, which when met, makes an individual unsuitable for a given task or participation in a given process" ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "chemotherapy treatment exclusion criterion" ; rdfs:subClassOf obo:OBI_0500028 . obo:OBI_0002425 obo:IAO_0000111 "radiation treatment exclusion criteria" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exclusion criterion that defines whether radiation was received or is being received for a previous or current cancer, which when met, makes an individual unsuitable for a given task or participation in a given process" ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "radiation treatment exclusion criteria" ; rdfs:subClassOf obo:OBI_0500028 . obo:OBI_0002426 obo:IAO_0000111 "chemotherapy treatment within the recent past exclusion criterion" ; obo:IAO_0000112 "An exclusion criterion defined by the pathologist is defined as whether the individual received chemotherapy within the last two years." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exclusion criterion that defines whether chemotherapy was received within a certain timeframe, which when met, makes an individual unsuitable for a given task or participation in a given process." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "chemotherapy treatment within the recent past exclusion criterion" ; rdfs:subClassOf obo:OBI_0500028 . obo:OBI_0002427 obo:IAO_0000111 "radiation treatment within the recent past exclusion criterion" ; obo:IAO_0000112 "An exclusion criterion defined by the pathologist is defined as whether the individual received radiation therapy within the last two years." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exclusion criterion that defines whether radiation was received within a certain timeframe, which when met, makes an individual unsuitable for a given task or participation in a given process." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "radiation treatment within the recent past exclusion criterion" ; rdfs:subClassOf obo:OBI_0500028 . obo:OBI_0002428 obo:IAO_0000111 "BMI range inclusion criterion" ; obo:IAO_0000112 "An important inclusion criterion is for for the individual to have a BMI between 18.5 and 35.0" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An inclusion criterion that defines and states a Body Mass Index range, which if met, makes an individual suitable for a given task or participation in a given process." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "BMI range inclusion criterion" ; rdfs:subClassOf obo:OBI_0500027 . obo:OBI_0002429 obo:IAO_0000111 "blood transfusion exclusion criterion" ; obo:IAO_0000112 "An exclusion criterion that is defined by whether the specimen donor received a whole blood transfusion within 48 hours prior to death." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exclusion criterion that is defined by whether the specimen donor received a whole blood transfusion within a specified time frame prior to death, which if met, makes a specimen donor unsuitable for a given task or participation in a given process." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "blood transfusion exclusion criterion" ; rdfs:subClassOf obo:OBI_0500028 . obo:OBI_0002430 obo:IAO_0000111 "history of metastatic cancer exclusion criterion" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exclusion criterion defined as whether an individual has ever been diagnosed with metastatic cancer (cancer that spread beyond the initial site such as to other organs like brain bone or liver), which if met, makes the individual unsuitable for a given task or participation in a given process." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "history of metastatic cancer exclusion criterion" ; rdfs:subClassOf obo:OBI_0500028 . obo:OBI_0002431 obo:IAO_0000111 "intravenous drug use exclusion criterion" ; obo:IAO_0000112 "Donor eligibility based on history of intravenous drug abuse in the last 5 years." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exclusion criterion defined as when an individual has a history of intravenous drug abuse for a specific timeframe, which if met, makes the individual unsuitable for a given task or participation in a given process." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "intravenous drug use exclusion criterion" ; rdfs:subClassOf obo:OBI_0500028 . obo:OBI_0002432 obo:IAO_0000111 "history of sex with someone with a history of blood borne infection exclusion criterion" ; obo:IAO_0000112 "Donor eligibility based on whether the donor has a history of sex with someone who has been diagnosed or at risk for HIV/AIDS and/or HCV and/or HBV in the last 5 years." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exclusion criterion defined as whether an individual has a history of sex with someone who has been diagnosed or at risk for a blood borne infections disease in a specified time frame, which if met, makes the individual unsuitable for a given task or participation in a given process." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "history of sex with someone with a history of blood borne infection exclusion criterion" ; rdfs:subClassOf obo:OBI_0500028 . obo:OBI_0002433 obo:IAO_0000111 "history of sex with someone with a history of intravenous drugs exclusion criterion" ; obo:IAO_0000112 "Donor eligibility based on whether the donor has a history of sex with someone who has used intravenous drugs in the last 5 years." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exclusion criterion defined as whether an individual has a history of sex with someone who has used intravenous drugs in a specified time frame, which if met, makes the individual unsuitable for a given task or participation in a given process." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "history of sex with someone with a history of intravenous drugs exclusion criterion" ; rdfs:subClassOf obo:OBI_0500028 . obo:OBI_0002434 obo:IAO_0000111 "HIV exclusion criterion" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exclusion criterion defined as whether an individual has a history of repeatedly reactive screening assays for HIV-1 or HIV-2 antibody regardless of the results of supplemental assays, which if met, makes the individual unsuitable for a given task or participation in a given process." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "HIV exclusion criterion" ; rdfs:subClassOf obo:OBI_0500028 . obo:OBI_0002435 obo:IAO_0000111 "exposure to blood borne infectious disease exclusion criterion" ; obo:IAO_0000112 "Donor eligibility based on whether the donor has been exposed to HIV/AIDS." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An exclusion criterion defined as whether an individual has been exposed to a blood borne infections disease through needle sticks and/or contact with non-intact skin and/or contact with open wounds and/or contact with mucous membranes, which if met, makes the individual unsuitable for a given task or participation in a given process." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis" ; obo:IAO_0000119 "NCI BBRB, OBIB" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "exposure to blood borne infectious disease exclusion criterion" ; rdfs:subClassOf obo:OBI_0500028 . obo:OBI_0002436 obo:IAO_0000111 "RNA interactome capture" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that identifies RNA binding proteins by cross-linking RNA and proteins with UV light, then purifying the bound complexes by oligo(dT) capture. Finally, the complexes are analyzed by mass spectrometry." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000119 "PMID:26463381" ; a owl:Class ; rdfs:label "RNA interactome capture" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000470 obo:OBI_0003368 ) ] ] . obo:OBI_0002437 obo:IAO_0000111 "widefield microscopy assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A fluorescence microscopy technique where the specimen under investigation is fully bathed in light, as opposed to confocal microscopy in which only a small portion of the specimen is illuminated." ; obo:IAO_0000117 "Jie Zheng" ; obo:IAO_0000118 "WFM" ; obo:IAO_0000119 "url:http://bitesizebio.com/19409/the-many-flavors-of-widefield-microscopy/", "url:https://svi.nl/WideFieldMicroscope" ; a owl:Class ; rdfs:label "widefield microscopy assay" ; rdfs:subClassOf obo:CHMO_0000087 . obo:OBI_0002438 obo:IAO_0000111 "nuclear ligation assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that detects the proximity of chromosomal DNA through the use of a ligation reaction in isolated nuclei." ; obo:IAO_0000117 "Chris S" ; obo:IAO_0000119 "PMID:8327891" ; a owl:Class ; rdfs:label "nuclear ligation assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000023089 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001398 ] . obo:OBI_0002439 obo:IAO_0000111 "chromosome conformation capture assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A nuclear ligation assay that detects chromosomal interactions between any two genomic loci. Chromatin segments are cross-linked, cut by restriction enzymes, ligated, and finally analyzed by PCR." ; obo:IAO_0000117 "Chris S" ; obo:IAO_0000118 "3C assay" ; obo:IAO_0000119 "PMID:11847345", "url:http://www.nature.com/nprot/journal/v2/n7/full/nprot.2007.243.html" ; a owl:Class ; rdfs:label "chromosome conformation capture assay" ; rdfs:subClassOf obo:OBI_0002438, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001917 ] . obo:OBI_0002440 obo:IAO_0000111 "Hi-C assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A chromosome conformation capture assay that detects genome-wide chromosomal interactions. High-throughput techniques are used to sequence the ligated fragments after cross-linking and cutting with restriction enzymes." ; obo:IAO_0000117 "Chris S" ; obo:IAO_0000119 "PMID:20461051" ; a owl:Class ; rdfs:label "Hi-C assay" ; rdfs:subClassOf obo:OBI_0002439, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000626 obo:OBI_0003368 ) ] ] . obo:OBI_0002441 obo:IAO_0000111 "physical examination of an organism" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay that produces a description of the qualities of an organism that has not been transformed, through observation and physical, non-invasive techniques." ; a owl:Class ; rdfs:label "physical examination of an organism" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0002442 obo:IAO_0000111 "hydroxyl-radical footprinting assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A footprinting assay that uses the reaction of hydroxyl radicals with side-chain sites in molecules (proteins, DNA, etc)_ with the resultant mass shift demonstrating the site of modification, used to_ to asses the accessibility of that site." ; obo:IAO_0000117 "Jie Zheng" ; obo:IAO_0000119 "PMID:21770468" ; a owl:Class ; rdfs:label "hydroxyl-radical footprinting assay" ; rdfs:subClassOf obo:OBI_0002162, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:CHEBI_23367 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_23367 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_61073 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_61073 ] ) ] . obo:OBI_0002443 obo:IAO_0000111 "methidiumpropyl-EDTA-iron(II) footprinting assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A footprinting assay that determines protein-binding sites on DNA by partial cleavage of ligand-protected DNA restriction fragments with methidium-propyl-EDTA (MPE). MPE-Fe(II) in the presence of oxygen efficiently catalyzes the non-specific clevage of DNA." ; obo:IAO_0000117 "Jie Zheng" ; obo:IAO_0000118 "MPE-Fe(II) footprinting" ; obo:IAO_0000119 "PMID:6225070", "PMID:6435669" ; a owl:Class ; rdfs:label "methidiumpropyl-EDTA-iron(II) footprinting assay" ; rdfs:subClassOf obo:OBI_0002162, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_59056 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_59056 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001181 ] . obo:OBI_0002444 obo:IAO_0000111 "measurand role"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A role borne by a material entity and realized in an assay which achieves the objective to measure the magnitude/concentration/amount of the measurand in the entity bearing evaluant role." ; obo:IAO_0000117 "Person: Alan Ruttenberg, Jie Zheng" ; obo:IAO_0000119 "https://en.wiktionary.org/wiki/measurand" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/778" ; a owl:Class ; rdfs:label "measurand role"@en ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:BFO_0000040 ] . obo:OBI_0002445 obo:IAO_0000111 "transcription start site mapping by primer extension assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A transcription profiling assay in which the transcription start site for a gene is determined by identifying the 5' end of mRNA. A radio-labeled primer is annealed to a complementary mRNA sequence near the 3' end, then cDNA is synthesized until the 5' end is reached." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000119 "PMID:23378648", "url:https://en.wikipedia.org/wiki/Primer_extension" ; a owl:Class ; rdfs:label "transcription start site mapping by primer extension assay" ; rdfs:subClassOf obo:OBI_0000424, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000880 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000973 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0010467 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001851 ] . obo:OBI_0002446 obo:IAO_0000111 "proteomic profiling design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design in which proteins in a sample are detected, quantified or otherwise analysed." ; obo:IAO_0000117 "Dan Berrios" ; obo:IAO_0000119 "OBI:0001441" ; a owl:Class ; rdfs:label "proteomic profiling design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0002447 obo:IAO_0000111 "suppression subtractive hybridization" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An artificially induced nucleic acid hybridization that is performed to compare gene expression in different cell or tissue types based on normalization and suppression, which creates a subtracted cDNA or genomic DNA library." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "SSH", "subtractive hybridization" ; obo:IAO_0000119 "PMID:14970460" ; a owl:Class ; rdfs:label "suppression subtractive hybridization" ; rdfs:subClassOf obo:OBI_0000253 . obo:OBI_0002448 obo:IAO_0000111 "differential screening hybridization" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An artificially induced nucleic acid hybridization that is performed to identify differentially expressed genes through hybridization of cDNA probes." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "DSH", "differential screening" ; obo:IAO_0000119 "PMID:25472628" ; a owl:Class ; rdfs:label "differential screening hybridization" ; rdfs:subClassOf obo:OBI_0000253 . obo:OBI_0002449 obo:IAO_0000111 "footprinting assay measuring binding of a B cell epitope:antibody complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A footprinting assay that detects the binding of an antigen with an antibody." ; obo:IAO_0000117 "PERSON:Randi Vita, James Overton, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "qualitative binding|footprinting assay" ; a owl:Class ; rdfs:label "footprinting assay measuring binding of a B cell epitope:antibody complex" ; rdfs:subClassOf obo:OBI_0001703, obo:OBI_0002162 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0002162 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0003141 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001702 ] ] ) ] . obo:OBI_0002450 obo:IAO_0000111 "hydroxyl-radical footprinting assay measuring binding of a B cell epitope:antibody complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A hydroxyl-radical footprinting assay that detects the binding of an antigen with an antibody." ; obo:IAO_0000117 "PERSON:Randi Vita, James Overton, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "qualitative binding|hydroxyl-radical footprinting assay" ; a owl:Class ; rdfs:label "hydroxyl-radical footprinting assay measuring binding of a B cell epitope:antibody complex" ; rdfs:subClassOf obo:OBI_0002442, obo:OBI_0002449 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0002442 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0003141 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001702 ] ] ) ] . obo:OBI_0002451 obo:IAO_0000111 "ELISA measuring epitope specific interferon-alpha production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interferon-alpha production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IFNa release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interferon-alpha production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0002452 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032607 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002452 obo:IAO_0000111 "assay measuring epitope specific interferon-alpha production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interferon-alpha production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IFNa release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interferon-alpha production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032607 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002453 obo:IAO_0000111 "health status inclusion criterion"@en ; obo:IAO_0000112 "‘diagnosed with Type 2 diabetes mellitus’, ‘E11.4’, ’not finding of hypertension'"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An inclusion criterion that defines and states one or more clinically significant bodily components, dispositions, and/or bodily processes of an entity that are inferred from relevant clinical findings or self-reported, which, if met, makes the entity suitable for a given task or participation in a given process."@en ; obo:IAO_0000117 "Mathias Brochhausen"@en ; obo:IAO_0000234 "MIABIS2.0"@en ; a owl:Class ; rdfs:label "health status inclusion criterion"@en ; rdfs:subClassOf obo:OBI_0500027 . obo:OBI_0002454 obo:IAO_0000111 "clinically relevant lifestyle inclusion criterion"@en ; obo:IAO_0000112 "'smoking behavior’"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An inclusion criterion that defines and states one or more clinically relevant planned processes that a human being actively participates in , which, if met, makes the human being suitable for a given task or participation in a given process."@en ; obo:IAO_0000117 "Mathias Brochhausen"@en ; obo:IAO_0000234 "MIABIS2.0"@en ; a owl:Class ; rdfs:label "clinically relevant lifestyle inclusion criterion"@en ; rdfs:subClassOf obo:OBI_0500027 . obo:OBI_0002455 obo:IAO_0000111 "clinically relevant exposure inclusion criterion"@en ; obo:IAO_0000112 "'exposure to cigarette smoke’, ‘exposure to lead through drinking water'"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An inclusion criterion that defines and states one or more clinically relevant histories of exposure of an entity, which, if met, makes the entity suitable for a given task or participation in a given process."@en ; obo:IAO_0000117 "Mathias Brochhausen"@en ; obo:IAO_0000234 "MIABIS2.0"@en ; a owl:Class ; rdfs:label "clinically relevant exposure inclusion criterion"@en ; rdfs:subClassOf obo:OBI_0500027 . obo:OBI_0002456 obo:IAO_0000111 "gravidity inclusion criterion"@en ; obo:IAO_0000112 "'pregnant’, ‘not pregnant'"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An inclusion criterion that defines and states one or more gravidity statuses of an organism, which, if met, makes the entity suitable for a given task or participation in a given process."@en ; obo:IAO_0000117 "Mathias Brochhausen"@en ; obo:IAO_0000234 "MIABIS2.0"@en ; a owl:Class ; rdfs:label "gravidity inclusion criterion"@en ; rdfs:subClassOf obo:OBI_0500027 . obo:OBI_0002457 obo:IAO_0000111 "precision nuclear run-on sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An RNA-seq assay that maps the genome-wide distribution of transcriptionally-engaged Pol II at base-pair resolution by using biotin-labeled ribonucleotide triphosphate analogs (biotin-NTP) for nuclear run-on reactions, allowing the efficient affinity purification of nascent RNAs for high throughput sequencing from their 3' ends." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "PRO-Seq", "precision nuclear run-on and sequencing assay" ; obo:IAO_0000119 "PMID:23430654" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/876" ; a owl:Class ; rdfs:label "precision nuclear run-on sequencing assay" ; rdfs:subClassOf obo:OBI_0001271, obo:OBI_0002692, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000552 ] . obo:OBI_0002458 obo:IAO_0000111 "chromosome conformation capture-on-chip assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A nuclear ligation assay which uses cross-linking of proteins to proteins and DNA, followed by two rounds of digestion and ligation, inverse PCR, and characterization by microarray or DNA sequencing. This enables unbiased genome-wide screens for DNA contacts made by single genomic sites of interest." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "4C assay", "circularized chromosome conformation capture assay" ; obo:IAO_0000119 "url:http://www.sciencedirect.com/science/article/pii/B9780123919380000045" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/875" ; a owl:Class ; rdfs:label "chromosome conformation capture-on-chip assay" ; rdfs:subClassOf obo:OBI_0002438, obo:OBI_0002692, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0002598 ] . obo:OBI_0002459 obo:IAO_0000111 "genotype phasing by Hi-C assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A genotyping assay in which carbon-copy chromosome conformation is used to detect polymorphism in DNA samples." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "haplotype reconstruction by Hi-C assay" ; obo:IAO_0000119 "PMID:19815776", "url:https://www.nature.com/articles/nbt.2728" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/828" ; a owl:Class ; rdfs:label "genotype phasing by Hi-C assay" ; rdfs:subClassOf obo:OBI_0000435, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002440 obo:OBI_0003368 ) ] ] . obo:OBI_0002460 obo:IAO_0000111 "defined population inclusion criterion" ; obo:IAO_0000112 "inclusion based on age, sex, and living region (rural area or specified city)." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An inclusion criterion that is based on fitting within the defined characteristics of a population based study design." ; obo:IAO_0000117 "Chris Stoeckert, Mathias Brochhausen" ; obo:IAO_0000119 "MIABIS 2.0" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/920" ; obo:IAO_0000234 "MIABIS 2.0" ; a owl:Class ; rdfs:label "defined population inclusion criterion"@en ; rdfs:subClassOf obo:OBI_0500027 . obo:OBI_0002461 obo:IAO_0000111 "BCL format"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A data format specification that is a binary file containing base calling data. These files are created by sequencing machines during the act of sequencing, and contain data about each of the nucleotide clusters on a sequencing flow cell."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; a owl:Class ; rdfs:label "BCL format"@en ; rdfs:subClassOf obo:IAO_0000098 . obo:OBI_0002462 obo:IAO_0000111 "ERCC RNA spike-in" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A processed material developed by the External RNA Controls Consortium (ERCC) that consists of 92 transcripts, derived and traceable from NIST-certified DNA plasmids."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; obo:IAO_0000119 "https://www.thermofisher.com/order/catalog/product/4456740"@en ; a owl:Class ; rdfs:label "ERCC RNA spike-in" ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Class ; owl:intersectionOf (obo:OBI_0000047 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0001140 ] ) ] . obo:OBI_0002463 obo:IAO_0000111 "SIRV RNA spike-in"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A processed material that consists of transcript isoforms of 7 spike-in RNA variant (SIRV) genes and possibly the 92 External RNA Controls Consortium (ERCC) RNA spike-in genes."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; obo:IAO_0000119 "https://www.lexogen.com/sirvs/design/"@en ; a owl:Class ; rdfs:label "SIRV RNA spike-in"@en ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Class ; owl:intersectionOf (obo:OBI_0000047 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0001140 ] ) ] . obo:OBI_0002464 obo:IAO_0000111 "SRS identifier"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An accession number that applies to a database record for an individual sample object in an NCBI Sequence Read Archive (SRA) submission. These records are imported from the NCBI BioSample database."@en ; obo:IAO_0000117 "Stephen Fisher, Dan Berrios"@en ; obo:IAO_0000118 "SRA sample accession number"@en ; a owl:Class ; rdfs:label "SRS identifier"@en ; rdfs:subClassOf obo:IAO_0000577 . obo:OBI_0002465 obo:IAO_0000111 "age since culture seeding measurement datum"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An age measurement datum that is the result of the measurement of the age of a cell since cultured (the process of seeding cells onto a culture dish)." ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" ; obo:IAO_0000118 "age of culture" ; a owl:Class ; rdfs:label "age since culture seeding measurement datum" ; rdfs:subClassOf obo:OBI_0001167 . obo:OBI_0002466 obo:IAO_0000111 "alignment counting algorithm"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An algorithm used to assign aligned sequence reads, resulting from a reference genome transcriptome alignment algorithm, to sequence features (e.g. genes or transcripts)."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; a owl:Class ; rdfs:label "alignment counting algorithm" ; rdfs:subClassOf obo:IAO_0000064 . obo:OBI_0002467 obo:IAO_0000111 "alignment counting application"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A software application that implements an alignment counting algorithm, used to count the overlap of aligned sequencing reads with genes."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; obo:IAO_0000119 "doi:10.1093/bioinformatics/btu638"@en ; a owl:Class ; rdfs:label "alignment counting application"@en ; rdfs:subClassOf obo:IAO_0000594 . obo:OBI_0002468 obo:IAO_0000111 "base calling algorithm"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An algorithm that assigns nucleotides to temporal or spatial peaks generated by a detector, such as peaks of light intensities generated by a DNA sequencer"@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; a owl:Class ; rdfs:label "base calling algorithm"@en ; rdfs:subClassOf obo:IAO_0000064 . obo:OBI_0002469 obo:IAO_0000111 "base calling application"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A base-calling application that implments a base-calling algorithm to convert BCL (binary base call) files, (e.g., those generated by Illumina sequencing systems) to standard FASTQ file formats for downstream analysis."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; a owl:Class ; rdfs:label "base calling application"@en ; rdfs:subClassOf obo:IAO_0000594 . obo:OBI_0002470 obo:IAO_0000111 "bcl2fastq software application"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A base calling application that implments a base calling algorithm to convert BCL (binary base call) files generated by Illumina sequencing systems to standard FASTQ file formats for downstream analysis."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; obo:IAO_0000119 "https://support.illumina.com/sequencing/sequencing_software/bcl2fastq-conversion-software.html"@en ; a owl:Class ; rdfs:label "bcl2fastq software application"@en ; rdfs:subClassOf obo:OBI_0002469 . obo:OBI_0002471 obo:IAO_0000111 "date process started"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A data item that is the date when a process was initiated."@en ; obo:IAO_0000117 "Chris Stoeckert, Daniel Berrios, Stephen A. Fisher"@en ; a owl:Class ; rdfs:label "date process started"@en ; rdfs:subClassOf obo:IAO_0000027 . obo:OBI_0002472 obo:IAO_0000111 "dbGaP study identifier"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A central registered identifier symbol that denotes a specific study in dbGaP."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; obo:IAO_0000118 "dbGaP accession number"@en ; obo:IAO_0000119 "doi:10.1038/ng1007-1181"@en ; a owl:Class ; rdfs:label "dbGaP study identifier"@en ; rdfs:subClassOf obo:IAO_0000577 . obo:OBI_0002473 obo:IAO_0000111 "material amplification role"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A worker role played by the person who runs the enzymatic amplifying process."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; a owl:Class ; rdfs:label "material amplification role"@en ; rdfs:subClassOf obo:OBI_0000116 . obo:OBI_0002474 obo:IAO_0000111 "material sequencing library preparation role"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A worker role played by the person who performs the library preparation process to generate a sequencing library for a sample to be sequenced."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; a owl:Class ; rdfs:label "material sequencing library preparation role"@en ; rdfs:subClassOf obo:OBI_0000116 . obo:OBI_0002475 obo:IAO_0000111 "number of PCR cycles during library construction"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item that is the number of PCR cycles used during the construction of a sequencing library."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; obo:IAO_0000118 "library construction PCR cycles"@en ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Polymerase_chain_reaction"@en ; a owl:Class ; rdfs:label "number of PCR cycles during library construction"@en ; rdfs:subClassOf obo:IAO_0000027 . obo:OBI_0002476 obo:IAO_0000111 "number of rounds of amplification"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A data item that is the number of times an amplification reaction happened."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; a owl:Class ; rdfs:label "number of rounds of amplification"@en ; rdfs:subClassOf obo:IAO_0000027 . obo:OBI_0002477 obo:IAO_0000111 "reference genome role"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A reference substance role that is played by a reference genome when used during sequence alignment."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; a owl:Class ; rdfs:label "reference genome role"@en ; rdfs:subClassOf obo:OBI_0000025 . obo:OBI_0002478 obo:IAO_0000111 "reference genome-transcriptome alignment algorithm"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An algorithm that attempts to align a nucleic acid sequence to a reference genome and transcriptome."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; a owl:Class ; rdfs:label "reference genome-transcriptome alignment algorithm"@en ; rdfs:subClassOf obo:IAO_0000064 . obo:OBI_0002479 obo:IAO_0000111 "sequence read length measurement datum"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A measurement datum that is the result of the measurement of the number of bases in a DNA or RNA sequence."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; obo:IAO_0000118 "read length, read length measurement datum"@en ; a owl:Class ; rdfs:label "sequence read length measurement datum"@en ; rdfs:subClassOf obo:IAO_0000109 . obo:OBI_0002480 obo:IAO_0000111 "sequencing library input quantity measurement datum"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A scalar measurement datum that indicates the amount of sequencing library used as input for a sequencer."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim"@en ; obo:IAO_0000118 "library input amount"@en ; a owl:Class ; rdfs:label "sequencing library input quantity measurement datum"@en ; rdfs:subClassOf obo:IAO_0000032 . obo:OBI_0002481 obo:IAO_0000111 "single-end library"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cDNA library that is a collection of short tags from only one end of DNA fragments."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; a owl:Class ; rdfs:label "single-end library"@en ; rdfs:subClassOf obo:OBI_0002754 . obo:OBI_0002482 obo:IAO_0000111 "specimen harvest quantity"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A scalar measurement datum that indicates the amount of specimen collected."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; obo:IAO_0000118 "harvest quantity"@en ; a owl:Class ; rdfs:label "specimen harvest quantity"@en ; rdfs:subClassOf obo:IAO_0000109 . obo:OBI_0002483 obo:IAO_0000111 "spike-in dilution factor"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A data item that indicates the dilution of spike-in added to a specimen."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en ; a owl:Class ; rdfs:label "spike-in dilution factor"@en ; rdfs:subClassOf obo:IAO_0000027 . obo:OBI_0002484 obo:IAO_0000111 "star algorithm"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A reference genome transcriptome alignment algorithm that is a standalone RNA-seq alignment algorithm that uses uncompressed suffix arrays and a mapping algorithm similar to those used in large-scale genome alignment tools to align RNA-seq reads to a genomic reference."@en ; obo:IAO_0000119 "Stephen A. Fisher, Junhyong Kim, Dan Berrios"@en, "https://www.ncbi.nlm.nih.gov/pubmed/23104886"@en ; a owl:Class ; rdfs:label "star algorithm"@en ; rdfs:subClassOf obo:OBI_0002478 . obo:OBI_0002485 obo:IAO_0000111 "transcript analysis by single-end sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A sequencing assay that incorporates single-end reads and sequencing technology to determine transcripts, gene structures, and gene expressions." ; obo:IAO_0000117 "Dan Berrios", "Junhyong Kim", "Stephen A. Fisher" ; obo:IAO_0000118 "transcript analysis by single-end sequencing" ; obo:IAO_0000119 "url:https://www.illumina.com/science/technology/next-generation-sequencing/paired-end-vs-single-read-sequencing.html" ; a owl:Class ; rdfs:label "transcript analysis by single-end sequencing assay" ; rdfs:subClassOf obo:OBI_0600047 . obo:OBI_0002486 obo:IAO_0000111 "verse algorithm"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An alignment counting algorithm that assigns gene features to genomic alignments using a hierarchical assignment scheme, which allows simultaneous quantification of multiple feature types or annotation levels without repeatedly assigning reads."@en ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim"@en ; obo:IAO_0000119 "http://kim.bio.upenn.edu/software/verse.shtml or http://biorxiv.org/content/early/2016/05/14/053306"@en ; a owl:Class ; rdfs:label "verse algorithm"@en ; rdfs:subClassOf obo:OBI_0002466 . obo:OBI_0002487 obo:IAO_0000111 "microraft" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A material separation device also commerically known as Isoraft, that is used to isolate single cells." ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Microrafts" ; a owl:Class ; rdfs:label "microraft" ; rdfs:subClassOf obo:OBI_0000932 . obo:OBI_0002488 obo:IAO_0000111 "pipette" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is a laboratory tool commonly used in chemistry, biology and medicine to transport a measured volume of liquid, often as a media dispenser." ; obo:IAO_0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Pipette" ; a owl:Class ; rdfs:label "pipette" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0002489 obo:IAO_0000111 "differential medium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that uses a differential medium to achieve its objective." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "EuPathDB, https://www.uwyo.edu/molb2210_lab/info/biochemical_tests.htm" ; a owl:Class ; rdfs:label "differential medium assay" ; rdfs:subClassOf obo:OBI_0003498, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0100051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100051 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000027 ] . obo:OBI_0002490 obo:IAO_0000111 "medication time value specification" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A scalar value specification that specifies the point in time that a human participant under investigation self-administers a medication material" ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "medication timepoint" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "medication time value specification" ; rdfs:subClassOf obo:OBI_0001931 . obo:OBI_0002491 obo:IAO_0000111 "medication dose value specification" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A scalar value specification that specifies the value of the quantity of a material entity administered to an organism as a treatment" ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "medication dose" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "medication dose value specification" ; rdfs:subClassOf obo:OBI_0001931 . obo:OBI_0002492 obo:IAO_0000111 "case role in case-control study"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A role that is borne by a case-control study design participant under investigation that is associated with the outcome mentioned in the study design."@en ; obo:IAO_0000117 "John Judkins, Bjoern Peters"@en ; obo:IAO_0000119 "OBI"@en ; a owl:Class ; rdfs:label "case role in case-control study"@en ; rdfs:subClassOf obo:OBI_0000097 . obo:OBI_0002493 obo:IAO_0000111 "control role in case-control study"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A role that is borne by a case-control study design participant under investigation that is not associated with the outcome mentioned in the study design."@en ; obo:IAO_0000117 "John Judkins, Bjoern Peters"@en ; obo:IAO_0000119 "OBI"@en ; a owl:Class ; rdfs:label "control role in case-control study"@en ; rdfs:subClassOf obo:OBI_0000097 . obo:OBI_0002500 obo:IAO_0000111 "amniotic fluid specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from amniotic fluid." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, Penn Medicine Biobank" ; a owl:Class ; rdfs:label "amniotic fluid specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0000173 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002501 obo:IAO_0000111 "bile specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from bile." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, Penn Medicine Biobank" ; a owl:Class ; rdfs:label "bile specimen" ; rdfs:subClassOf obo:OBI_2000009 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0001970 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002502 obo:IAO_0000111 "cerebrospinal fluid specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from cerbrospinal fluid." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, Penn Medicine Biobank" ; a owl:Class ; rdfs:label "cerebrospinal fluid specimen" ; rdfs:subClassOf obo:OBI_2000009 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002503 obo:IAO_0000111 "feces specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from feces." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000118 "stool specimen" ; obo:IAO_0000119 "Chris Stoeckert, Penn Medicine Biobank" ; a owl:Class ; rdfs:label "feces specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0001988 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002504 obo:IAO_0000111 "digestive system fluid or secretion specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from digestive system fluid or secretion." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000118 "gastric fluid specimen" ; obo:IAO_0000119 "Chris Stoeckert, Penn Medicine Biobank" ; a owl:Class ; rdfs:label "digestive system fluid or secretion specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0006911 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002505 obo:IAO_0000111 "milk specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from milk." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, Penn Medicine Biobank" ; a owl:Class ; rdfs:label "milk specimen" ; rdfs:subClassOf obo:OBI_2000009 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0001913 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002506 obo:IAO_0000111 "pericardial fluid specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from pericardial fluid." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, Penn Medicine Biobank" ; a owl:Class ; rdfs:label "pericardial fluid specimen" ; rdfs:subClassOf obo:OBI_2000009 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0002409 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002507 obo:IAO_0000111 "saliva specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from saliva." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, Penn Medicine Biobank" ; a owl:Class ; rdfs:label "saliva specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0001836 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002508 obo:IAO_0000111 "sputum specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from sputum." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, Penn Medicine Biobank" ; a owl:Class ; rdfs:label "sputum specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0007311 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002509 obo:IAO_0000111 "sweat specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from sweat." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, Penn Medicine Biobank" ; a owl:Class ; rdfs:label "sweat specimen" ; rdfs:subClassOf obo:OBI_2000009 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0001089 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002510 obo:IAO_0000111 "synovial fluid specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from synovial fluid." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, Penn Medicine Biobank" ; a owl:Class ; rdfs:label "synovial fluid specimen" ; rdfs:subClassOf obo:OBI_2000009 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0001090 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002511 obo:IAO_0000111 "vitreous humor specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from vireous humor." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000118 "vitreous fluid specimen" ; obo:IAO_0000119 "Chris Stoeckert, Penn Medicine Biobank" ; a owl:Class ; rdfs:label "vitreous humor specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001797 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002512 obo:IAO_0000111 "bone marrow specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from bone marrow." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, Penn Medicine Biobank" ; a owl:Class ; rdfs:label "bone marrow specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0002371 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002662 ] ) ] ) ] . obo:OBI_0002513 obo:IAO_0000111 "placenta specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from placenta." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, Penn Medicine Biobank" ; a owl:Class ; rdfs:label "placenta specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002514 obo:IAO_0000111 "peritoneal fluid specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from peritoneal fluid." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, Penn Medicine Biobank" ; a owl:Class ; rdfs:label "peritoneal fluid specimen" ; rdfs:subClassOf obo:OBI_2000009 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0001268 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002515 obo:IAO_0000111 "pleural fluid specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from pleural fluid." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, Penn Medicine Biobank" ; a owl:Class ; rdfs:label "pleural fluid specimen" ; rdfs:subClassOf obo:OBI_2000009 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0001087 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002516 obo:IAO_0000111 "brain specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from brain." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "brain specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002517 obo:IAO_0000111 "hair specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from hair." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "hair specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0001037 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002518 obo:IAO_0000111 "prostate gland specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from prostate gland." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "prostate gland specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002519 obo:IAO_0000111 "skeletal muscle tissue specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from skeletal muscle." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "skeletal muscle tissue specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0001134 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002520 obo:IAO_0000111 "heart specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from heart." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "heart specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002521 obo:IAO_0000111 "renal medulla specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from renal medulla." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000118 "kidney medulla specimen" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "renal medulla specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000362 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002522 obo:IAO_0000111 "adrenal gland specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from adrenal gland." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "adrenal gland specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002369 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002523 obo:IAO_0000111 "breast specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from breast." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000118 "mammary tissue specimen" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "breast specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000310 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002524 obo:IAO_0000111 "urinary bladder specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from urinary bladder." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "urinary bladder specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002525 obo:IAO_0000111 "tibial artery specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from tibial artery." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "tibial artery specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007610 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002526 obo:IAO_0000111 "skin of body specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from skin." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000118 "skin specimen" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "skin of body specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002097 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002527 obo:IAO_0000111 "pancreas specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from pancreas." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "pancreas specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002528 obo:IAO_0000111 "stomach specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from stomach." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "stomach specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002529 obo:IAO_0000111 "pituitary gland specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from pituitary gland." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "pituitary gland specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000007 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002530 obo:IAO_0000111 "adipose tissue specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from adipose tissue." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "adipose tissue specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0001013 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002531 obo:IAO_0000111 "cortex of kidney specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from cortex of kidney." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000118 "kidney cortex specimen" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "cortex of kidney specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001225 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002532 obo:IAO_0000111 "esophagus mucosa specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from esophagus mucosa." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "esophagus mucosa specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002469 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002533 obo:IAO_0000111 "colon specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from colon." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "colon specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002534 obo:IAO_0000111 "lung specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from lung." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "lung specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002535 obo:IAO_0000111 "esophagus muscularis mucosa specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from esophagus muscularis mucosa." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000118 "esophagus muscularis specimen" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "esophagus muscularis mucosa specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004648 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002536 obo:IAO_0000111 "cerebral cortex specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from cerebral cortex." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000118 "brain cortex specimen" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "cerebral cortex specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002537 obo:IAO_0000111 "thyroid gland specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from thyroid gland." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "thyroid gland specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002046 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002538 obo:IAO_0000111 "cerebellum specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from cerebellum." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000118 "brain cerebellum specimen" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "cerebellum specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002539 obo:IAO_0000111 "tibial nerve specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from tibial nerve." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "tibial nerve specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001323 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002540 obo:IAO_0000111 "coronary artery specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from coronary artery." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "coronary artery specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001621 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002541 obo:IAO_0000111 "spleen specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from spleen." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "spleen specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002542 obo:IAO_0000111 "aorta specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from aorta." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "aorta specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000947 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002543 obo:IAO_0000111 "atrial appendage specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from the atrium auricular region." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "atrial appendage specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006618 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002544 obo:IAO_0000111 "esophagogastric junction specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from the esophagogastric junction." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "esophagogastric junction specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007650 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002545 obo:IAO_0000111 "ileum specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from ileum." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "ileum specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002116 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002546 obo:IAO_0000111 "liver specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from liver." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "liver specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002547 obo:IAO_0000111 "minor salivary gland specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from minor salivary gland." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "minor salivary gland specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001830 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002548 obo:IAO_0000111 "omentum specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from omentum." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "omentum specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003688 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002549 obo:IAO_0000111 "ovary specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from female gonad." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "ovary specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002550 obo:IAO_0000111 "sigmoid colon specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from sigmoid colon." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "sigmoid colon specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001159 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002551 obo:IAO_0000111 "suprapubic skin specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from suprapubic skin." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "suprapubic skin specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0036149 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002552 obo:IAO_0000111 "testis specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from testis." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "testis specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000473 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002553 obo:IAO_0000111 "uterus specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from uterus." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "uterus specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002554 obo:IAO_0000111 "vagina specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is derived from vagina." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, NCI BBRB" ; a owl:Class ; rdfs:label "vagina specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0002555 obo:IAO_0000111 "age group inclusion criterion"@en ; obo:IAO_0000112 "\"18-33 years old\""@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An inclusion criterion that defines and states an age bracket which, if met, makes an entity suitable for a given task or participation in a given process." ; obo:IAO_0000117 "Mathias Brochhausen" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/839" ; a owl:Class ; rdfs:label "age group inclusion criterion"@en ; rdfs:subClassOf obo:OBI_0500027, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0002556 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0002557 ] ) ] . obo:OBI_0002556 obo:IAO_0000111 "minimum age value specification"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A value specifcation that specifies the youngest age when specifying an age range."@en ; obo:IAO_0000117 "Mathias Brochhausen"@en ; a owl:Class ; rdfs:label "minimum age value specification"@en ; rdfs:subClassOf obo:OBI_0001933 . obo:OBI_0002557 obo:IAO_0000111 "maximum age value specification"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A value specifcation that specifies the oldest age when specifying an age range."@en ; obo:IAO_0000117 "Mathias Brochhausen"@en ; a owl:Class ; rdfs:label "maximum age value specification"@en ; rdfs:subClassOf obo:OBI_0001933 . obo:OBI_0002558 obo:IAO_0000111 "use of medication inclusion criterion"@en ; obo:IAO_0000112 "\"received at least 2 days of vancomycin\""@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An inclusion criterion that defines and states a a set of medications, which, if used by an entity, makes that entity suitable for a given task or participation in a given process."@en ; obo:IAO_0000117 "Mathias Brochhausen"@en ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/840"@en ; a owl:Class ; rdfs:label "use of medication inclusion criterion"@en ; rdfs:subClassOf obo:OBI_0500027 . obo:OBI_0002559 obo:IAO_0000111 "hospital patient inclusion criterion"@en ; obo:IAO_0000112 "\"included hospital patients\""@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An inclusion criterion defines that a human being has to be a hospital patient to be suitable for a given task or participation in a given process."@en ; obo:IAO_0000117 "Mathias Brochhausen"@en ; a owl:Class ; rdfs:label "hospital patient inclusion criterion"@en ; rdfs:subClassOf obo:OBI_0500027 . obo:OBI_0002560 obo:IAO_0000111 "family status inclusion criterion"@en ; obo:IAO_0000112 "\"included married and unmarried patients\", \"included divorced individuals\""@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An inclusion criterion that defines and states one or more family statuses, which, if met, makes a human being suitable for a given task or participation in a given process."@en ; obo:IAO_0000117 "Mathias Brochhausen"@en ; a owl:Class ; rdfs:label "family status inclusion criterion"@en ; rdfs:subClassOf obo:OBI_0500027 . obo:OBI_0002561 obo:IAO_0000111 "sex inclusion criterion"@en ; obo:IAO_0000112 "\"included males and females\", \"included male patients\""@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An inclusion criterion that defines and states one or more sexes which, if met, makes an entity suitable for a given task or participation in a given process."@en ; obo:IAO_0000117 "Mathias Brochhausen"@en ; a owl:Class ; rdfs:label "sex inclusion criterion"@en ; rdfs:subClassOf obo:OBI_0500027 . obo:OBI_0002562 obo:IAO_0000111 "country of residence inclusion criteria"@en ; obo:IAO_0000112 "\"include US residents\""@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An inclusion criterion that defines and states one or more countries of residence which, if met, makes a human being suitable for a given task or participation in a given process."@en ; obo:IAO_0000117 "Mathias Brochhausen"@en ; a owl:Class ; rdfs:label "country of residence inclusion criteria"@en ; rdfs:subClassOf obo:OBI_0500027 . obo:OBI_0002563 obo:IAO_0000111 "ethnicity inclusion criterion"@en ; obo:IAO_0000112 "\"include only Hispanic individuals\""@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An inclusion criteria that defines and states one or more ethnicities which, if met, makes an entity suitable for a given task or participation in a given process."@en ; obo:IAO_0000117 "Mathias Brochhausen"@en ; a owl:Class ; rdfs:label "ethnicity inclusion criterion"@en ; rdfs:subClassOf obo:OBI_0500027 . obo:OBI_0002564 obo:IAO_0000111 "histopathology assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A histological assay that is intended to check for the presence or level of a specific disease." ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "histopathology assay" ; rdfs:subClassOf obo:OBI_0600020 . obo:OBI_0002565 obo:IAO_0000111 "adapter-sequence trimming" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data transformation in which adapter sequences at the end of a molecular sequence are cut (removed)." ; obo:IAO_0000117 "Dan Berrios" ; obo:IAO_0000119 "Dan Berrios" ; a owl:Class ; rdfs:label "adapter-sequence trimming" ; rdfs:subClassOf obo:OBI_0002585, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0002578 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0002579 ] . obo:OBI_0002566 obo:IAO_0000111 "file merge" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data transformation in which data contained in 2 or more files are merged into a single file." ; obo:IAO_0000117 "Dan Berrios" ; obo:IAO_0000119 "Dan Berrios" ; a owl:Class ; rdfs:label "file merge" ; rdfs:subClassOf obo:OBI_0200000 . obo:OBI_0002567 obo:IAO_0000111 "sequence alignment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data transformation in which one or more sequences (reads) are positioned on a reference sequence template (often a reference set of genes), according to the genetic base-pairing paradigm." ; obo:IAO_0000117 "Dan Berrios" ; obo:IAO_0000119 "Dan Berrios" ; a owl:Class ; rdfs:label "sequence alignment" ; rdfs:subClassOf obo:OBI_0200187, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000973 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0002580 ] . obo:OBI_0002568 obo:IAO_0000111 "sequence data feature count tabulation" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The counting of features (typically, genes) within aligned sequence data, and organization of these counts into one or more tables." ; obo:IAO_0000117 "Dan Berrios" ; obo:IAO_0000119 "Dan Berrios" ; a owl:Class ; rdfs:label "sequence data feature count tabulation" ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200187, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0002580 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0002582 ] . obo:OBI_0002569 obo:IAO_0000111 "trimmed sequence data" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The results of a data transformation of sequence data in which (e.g., low quality) read bases are removed, to achieve some specific objective." ; obo:IAO_0000117 "Dan Berrios" ; obo:IAO_0000119 "Dan Berrios" ; a owl:Class ; rdfs:label "trimmed sequence data" ; rdfs:subClassOf obo:OBI_0000973 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000973 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002585 ] ) ] . obo:OBI_0002570 obo:IAO_0000111 "nCounter Mouse miRNA Expression array" ; obo:IAO_0000112 "Kolbert, Christopher P., et al. \"Multi-platform analysis of microRNA expression measurements in RNA from fresh frozen and FFPE tissues.\" PloS one 8.1 (2013): e52517. PMID:23382819" ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "A mouse array which is manufacutred by NanoString Technologies. Built upon color-coded molecular barcodes technology, the array profiles miRNA with increased specificity and sensitivty than microarrays." ; obo:IAO_0000117 "PERSON: Venkat Malladi, Chris Stoeckert, Jie Zheng, Alan Ruttenberg. Mark A. Miller added based on http://purl.obolibrary.org/obo/OBI_0002013" ; obo:IAO_0000119 "https://www.nanostring.com/products/mirna-assays/mirna-panels" ; a owl:Class ; rdfs:label "nCounter Mouse miRNA Expression array" ; rdfs:subClassOf obo:OBI_0001865, [ a owl:Restriction ; owl:hasValue obo:OBI_0001860 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002571 obo:IAO_0000111 "polyA-selected RNA sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An RNA-seq assay to study transcriptomes through the enrichment of polyadenylated transcripts or removal of ribosomal RNA prior to high-throughput sequencing." ; obo:IAO_0000117 "Jason Hilton", "Mark A. Miller" ; obo:IAO_0000118 "mRNA-seq" ; obo:IAO_0000119 "url:https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-15-419" ; obo:IAO_0000234 "ENCODE" ; a owl:Class ; rdfs:label "polyA-selected RNA sequencing assay" ; rdfs:subClassOf obo:OBI_0001271, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000869 ] . obo:OBI_0002572 obo:IAO_0000111 "polyA-depleted RNA sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An RNA-seq assay to study non-polyadenylated transcripts, such as, but not exclusive to unspliced and circular isoforms, through the depletion of polyadenylated transcripts prior to high-throughput sequencing." ; obo:IAO_0000117 "Jason Hilton", "Mark A. Miller" ; obo:IAO_0000118 "polyA-depleted RNA-seq" ; obo:IAO_0000119 "url:http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030733", "url:http://www.tandfonline.com/doi/full/10.1080/15476286.2015.1110676" ; obo:IAO_0000234 "ENCODE" ; a owl:Class ; rdfs:label "polyA-depleted RNA sequencing assay" ; rdfs:subClassOf obo:OBI_0001271, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0002573 ] . obo:OBI_0002573 obo:IAO_0000111 "polyA depleted RNA extract" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A RNA extract that is the output of an extraction process in which RNA molecules lacking poly A tails at thier 3' ends are purified." ; obo:IAO_0000117 "Mark A. Miller, based on http://purl.obolibrary.org/obo/OBI_0000869", "PERSON: Chris Stoeckert", "PERSON: Jie Zheng" ; obo:IAO_0000119 "UPenn Group" ; dc:date "2018-05-11T16:35:11Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "polyA depleted RNA extract" ; rdfs:subClassOf obo:OBI_0000880, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002574 ] . obo:OBI_0002574 obo:IAO_0000111 "RNA extraction with polyA depletion" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A RNA extraction process in which only RNAs lacking a polyA tail are retained" ; obo:IAO_0000117 "Mark A. Miller, based on OBI_0000848" ; obo:IAO_0000119 "UPenn Group" ; dc:date "2018-05-11T15:01:14Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "RNA extraction with polyA depletion" ; rdfs:subClassOf obo:OBI_0666666 . obo:OBI_0002575 obo:IAO_0000111 "isoform sequencing" ; obo:IAO_0000112 "Novel transcript forms were assessed by isoform sequencing." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A method for sequencing isoforms by enriching a cDNA library for full-length reads spanning entire transcript isoforms." ; obo:IAO_0000118 "ISO-seq" ; obo:IAO_0000119 "url:http://www.pacb.com/blog/intro-to-iso-seq-method-full-leng/" ; a owl:Class ; rdfs:label "isoform sequencing" ; rdfs:subClassOf obo:OBI_0001271 . obo:OBI_0002578 obo:IAO_0000111 "adapter sequence data" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Nucleotide sequences of molecules that are ligated to assay samples prior to sequencing of these samples; these sequences are provided by assay kit manufacturers and typically used to combine sequencing of multiple samples in one assay run." ; obo:IAO_0000117 "Dan Berrios" ; obo:IAO_0000119 "Dan Berrios" ; a owl:Class ; rdfs:label "adapter sequence data" ; rdfs:subClassOf obo:OBI_0000973 . obo:OBI_0002579 obo:IAO_0000111 "adapter-trimmed sequence data" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The results of a data transformation of sequence data in which reference subsequences corresponding to ligated library adapters are removed." ; obo:IAO_0000117 "Dan Berrios" ; obo:IAO_0000119 "Dan Berrios" ; a owl:Class ; rdfs:label "adapter-trimmed sequence data" ; rdfs:subClassOf obo:OBI_0000973 . obo:OBI_0002580 obo:IAO_0000111 "aligned sequence data" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The results of a sequence alignment." ; obo:IAO_0000117 "Dan Berrios" ; obo:IAO_0000119 "Dan Berrios" ; a owl:Class ; rdfs:label "aligned sequence data" ; rdfs:subClassOf obo:OBI_0000973 . obo:OBI_0002581 obo:IAO_0000111 "merged aligned sequence data" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The results of a data transformation of sequence data in which files containing aligned sequence data are merged together" ; obo:IAO_0000117 "Dan Berrios" ; obo:IAO_0000119 "Dan Berrios" ; a owl:Class ; rdfs:label "merged aligned sequence data" ; rdfs:subClassOf obo:OBI_0000973, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002566 ] . obo:OBI_0002582 obo:IAO_0000111 "sequence library feature count data" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The results of a sequence data feature count tabulation." ; obo:IAO_0000117 "Dan Berrios" ; obo:IAO_0000119 "Dan Berrios" ; a owl:Class ; rdfs:label "sequence library feature count data" ; rdfs:subClassOf obo:IAO_0000100 . obo:OBI_0002583 obo:IAO_0000111 "DNA methylation profiling data" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The results of a DNA methylation profiling assay" ; a owl:Class ; rdfs:label "DNA methylation profiling data" ; rdfs:subClassOf obo:OBI_0000973, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000634 ] . obo:OBI_0002584 obo:IAO_0000111 "differential expression analysis data" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The results of a differential expression analysis." ; a owl:Class ; rdfs:label "differential expression analysis data" ; rdfs:subClassOf obo:IAO_0000100 . obo:OBI_0002585 obo:IAO_0000111 "sequence trimming" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A data transformation in which subsequences of a molecular sequence are cut (removed)." ; a owl:Class ; rdfs:label "sequence trimming" ; rdfs:subClassOf obo:OBI_0200000 . obo:OBI_0002586 obo:IAO_0000111 "digital acquisition card" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The digital acquisition card acts as the interface between the computer and a measurement device via the computer bus. It converts the signal generated by a measurement device (output from device) to a digital signal via an analog-to-digital converter, ADC. It also converts a digital signal to an analog signal via a digital-to-analog converter, DAC. This analog signal (e.g., stimulus) is fed to a measurement device (input to device)." ; obo:IAO_0000117 "Mark A. Miller" ; obo:IAO_0000118 "DAQ device", "digital acquisition and digital generation card" ; obo:IAO_0000119 "Brenda Farrell, bfarrell@bcm.edu" ; a owl:Class ; rdfs:label "digital acquisition card" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000393 ] . obo:OBI_0002587 obo:IAO_0000111 "machine learning" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process with the objective to give a computer the ability to use patterns in data to progressively improve its performance on a specific task, achieved by using statistical techniques instead of explicitly programming the ability." ; obo:IAO_0000117 "Mark A. Miller" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Machine_learning" ; dc:contributor "https://github.com/TrisSN" ; a owl:Class ; rdfs:label "machine learning" ; rdfs:subClassOf obo:OBI_0000011 . obo:OBI_0002588 obo:IAO_0000111 "supervised machine learning" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A machine learning process using a function that maps an input to an output based on example input-output pairs. It infers a function from labeled training data consisting of a set of training examples." ; obo:IAO_0000117 "Mark A. Miller" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Supervised_learning" ; dc:contributor "https://github.com/TrisSN" ; a owl:Class ; rdfs:label "supervised machine learning" ; rdfs:subClassOf obo:OBI_0002587 . obo:OBI_0002589 obo:IAO_0000111 "unsupervised machine learning" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A machine learning process that infers a function describing the structure of \"unlabeled\" data (i.e. data that has not been classified or categorized)." ; obo:IAO_0000117 "Mark A. Miller" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Unsupervised_learning" ; dc:contributor "https://github.com/TrisSN" ; a owl:Class ; rdfs:label "unsupervised machine learning" ; rdfs:subClassOf obo:OBI_0002587 . obo:OBI_0002590 obo:IAO_0000111 "molecular interaction identification design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that investigates the features of interaction between molecules." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000119 "person:RCT" ; a owl:Class ; rdfs:label "molecular interaction identification design" ; rdfs:subClassOf obo:OBI_0500000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000131 ] . obo:OBI_0002591 obo:IAO_0000111 "colocalization identification design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A molecular interaction identification design that investigates the co-occurence and correlation of two or more molecules." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Colocalization" ; a owl:Class ; rdfs:label "colocalization identification design" ; rdfs:subClassOf obo:OBI_0002590 . obo:OBI_0002592 obo:IAO_0000111 "genetic interaction identification design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A molecular interaction identification design that investigates a phenotype that is the result of two or more genetic perturbations, and is not explained by the individual genetic perturbations alone." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000119 "MI:0208" ; a owl:Class ; rdfs:label "genetic interaction identification design" ; rdfs:subClassOf obo:OBI_0002590, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000750 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001404 ] ) ] ] . obo:OBI_0002593 obo:IAO_0000111 "functional association identification design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A molecular interaction identification design that investigates a relationship that is the result of intermediate steps between two or more molecules that are not necessarily in direct contact with each other." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000119 "MI:2286" ; a owl:Class ; rdfs:label "functional association identification design" ; rdfs:subClassOf obo:OBI_0002590 . obo:OBI_0002594 obo:IAO_0000111 "direct interaction identification design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A molecular interaction identification design that investigates the influence of molecules, which are in direct contact, on one another." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "molecular binding identification design" ; obo:IAO_0000119 "MI:0407" ; a owl:Class ; rdfs:label "direct interaction identification design" ; rdfs:subClassOf obo:OBI_0002590, [ a owl:Restriction ; owl:onProperty obo:RO_0000058 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:BFO_0000054 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001146 ] ] ] . obo:OBI_0002595 obo:IAO_0000111 "enzymatic reaction identification design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A direct interaction identification design that investigations a biological reaction on a molecule which has been triggered by an enzyme." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000119 "MI:0414" ; a owl:Class ; rdfs:label "enzymatic reaction identification design" ; rdfs:subClassOf obo:OBI_0002594 . obo:OBI_0002596 obo:IAO_0000111 "self interaction identification design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A molecular interaction identification design that investigates intra-molecular interactions between two or more regions of a single molecule." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000119 "MI:1126" ; a owl:Class ; rdfs:label "self interaction identification design" ; rdfs:subClassOf obo:OBI_0002590 . obo:OBI_0002597 obo:IAO_0000111 "chromosome conformation capture sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A chromosome conformation capture-on-chip assay quantitates the products with multiplexed high-throughput sequencing." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "3C-seq assay" ; obo:IAO_0000119 "PMID:23411633" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/939" ; a owl:Class ; rdfs:label "chromosome conformation capture sequencing assay" ; rdfs:subClassOf obo:OBI_0002458, obo:OBI_0600047, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001108 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001108 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001010 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001010 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000973 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:SO_0000001 ] ] . obo:OBI_0002598 obo:IAO_0000111 "inverse polymerase chain reaction" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A polymerase chain reaction which amplifies DNA with only one known sequence from which primers may be designed. A series of restriction digestions and ligations result in a looped DNA fragment which can be primed for PCR." ; obo:IAO_0000117 "Rebecca Tauber" ; obo:IAO_0000118 "inverse PCR" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Chromosome_conformation_capture" ; a owl:Class ; rdfs:label "inverse polymerase chain reaction" ; rdfs:subClassOf obo:OBI_0000415 . obo:OBI_0002599 obo:IAO_0000111 "swab specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is stored on a swab as the output of a collecting specimen with swab process." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "OBIB/OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/910" ; obo:IAO_0000234 "OBIB" ; a owl:Class ; rdfs:label "swab specimen" ; rdfs:subClassOf obo:OBI_0100051 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] . obo:OBI_0002600 obo:IAO_0000111 "collecting specimen with swab" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen collection process that uses a swab as the collection device. A swab is an absorbent material (e.g. cotton) on a rod (e.g., wooden stick)." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "OBIB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/910" ; obo:IAO_0000234 "OBIB" ; a owl:Class ; rdfs:label "collecting specimen with swab" ; rdfs:subClassOf obo:OBI_0000659 . obo:OBI_0002601 obo:IAO_0000111 "demultiplexed sequence data" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Sequence data in which an identifier subsequence has been used to categorize each reads by source." ; obo:IAO_0000117 "Dan Berrios" ; obo:IAO_0000119 "Dan Berrios" ; a owl:Class ; rdfs:label "demultiplexed sequence data" ; rdfs:subClassOf obo:OBI_0000973 . obo:OBI_0002602 obo:IAO_0000111 "multiplexed sequence data" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Sequence data from a sequence library generated from at least two different sources, where each read in the sequence data includes base calls from a multiplex identifier sequence that can be used to trace the source of the read to its source." ; obo:IAO_0000117 "Dan Berrios" ; obo:IAO_0000119 "Dan Berrios" ; a owl:Class ; rdfs:label "multiplexed sequence data" ; rdfs:subClassOf obo:OBI_0000973 . obo:OBI_0002603 obo:IAO_0000111 "areolar swab specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is collected with a swab from the surface of an areola of a breast." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, OBIB" ; a owl:Class ; rdfs:label "areolar swab specimen" ; rdfs:subClassOf obo:OBI_0002599 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0002032 ] ) ] ] ) ] ) ] . obo:OBI_0002604 obo:IAO_0000111 "breast swab specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is collected with a swab from the surface of a breast." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, OBIB" ; a owl:Class ; rdfs:label "breast swab specimen" ; rdfs:subClassOf obo:OBI_0002599 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0000310 ] ) ] ] ) ] ) ] . obo:OBI_0002605 obo:IAO_0000111 "cheek swab specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is collected with a swab from the cheek portion of the inside surface of a mouth." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, OBIB" ; a owl:Class ; rdfs:label "cheek swab specimen" ; rdfs:subClassOf obo:OBI_0002599 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0001567 ] ) ] ] ) ] ) ] . obo:OBI_0002606 obo:IAO_0000111 "nasopharyngeal swab specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is collected with a swab from the surface of a nasopharynx." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, OBIB" ; a owl:Class ; rdfs:label "nasopharyngeal swab specimen" ; rdfs:subClassOf obo:OBI_0002599 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0001728 ] ) ] ] ) ] ) ] . obo:OBI_0002607 obo:IAO_0000111 "oral swab specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is collected with a swab from the inside surface of a mouth." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, OBIB" ; a owl:Class ; rdfs:label "oral swab specimen" ; rdfs:subClassOf obo:OBI_0002599 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0000165 ] ) ] ] ) ] ) ] . obo:OBI_0002608 obo:IAO_0000111 "oropharyngeal swab specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is collected with a swab from the surface of a oropharynx." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, OBIB" ; a owl:Class ; rdfs:label "oropharyngeal swab specimen" ; rdfs:subClassOf obo:OBI_0002599 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0001729 ] ) ] ] ) ] ) ] . obo:OBI_0002609 obo:IAO_0000111 "rectal swab specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is collected with a swab from the surface of a rectum." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, OBIB" ; a owl:Class ; rdfs:label "rectal swab specimen" ; rdfs:subClassOf obo:OBI_0002599 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0001052 ] ) ] ] ) ] ) ] . obo:OBI_0002610 obo:IAO_0000111 "tongue swab specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is collected with a swab from the surface of a tongue." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, OBIB" ; a owl:Class ; rdfs:label "tongue swab specimen" ; rdfs:subClassOf obo:OBI_0002599 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] ] ) ] ) ] . obo:OBI_0002611 obo:IAO_0000111 "vagina swab specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is collected with a swab from the surface of a vagina." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, OBIB" ; a owl:Class ; rdfs:label "vagina swab specimen" ; rdfs:subClassOf obo:OBI_0002599 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] ] ) ] ) ] . obo:OBI_0002612 obo:IAO_0000111 "fecal swab specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is collected with a swab from the surface of a feces." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000118 "stool swab specimen" ; obo:IAO_0000119 "Chris Stoeckert, OBIB" ; a owl:Class ; rdfs:label "fecal swab specimen" ; rdfs:subClassOf obo:OBI_0002599 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0001988 ] ) ] ] ) ] ) ] . obo:OBI_0002613 obo:IAO_0000111 "environmental swab specimen" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen that is collected with a swab from the surface of an environmenal material." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Chris Stoeckert, OBIB" ; a owl:Class ; rdfs:label "environmental swab specimen" ; rdfs:subClassOf obo:OBI_0002599 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:ENVO_00010483 ] ) ] ] ) ] ) ] . obo:OBI_0002614 obo:IAO_0000111 "birth cohort study design" ; obo:IAO_0000112 "The LucKi Birth Cohort Study was designed and started in 2006 to follow children from birth into adulthood on a wide range of determinants, disorders, and diseases." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cohort study design for which the subjects are followed from the time of birth usually including information about gestation and follow up." ; obo:IAO_0000117 "MIABIS" ; obo:IAO_0000119 "MIABIS contributors" ; a owl:Class ; rdfs:label "birth cohort study design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0002615 obo:IAO_0000111 "disease specific study design" ; obo:IAO_0000112 "A study of the symptoms experienced by patients who have been diagnosed with multiple sclerosis employs a disease specific study design." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design for which material and information is collected from subjects that have already developed a particular disease." ; obo:IAO_0000117 "MIABIS" ; obo:IAO_0000119 "MIABIS contributors" ; a owl:Class ; rdfs:label "disease specific study design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0002616 obo:IAO_0000111 "genealogical record"@en ; obo:IAO_0000112 "A family tree is a type of genealogical record." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A document about the family relationships of persons related as members of a domestic group linked through descent from a common ancestor, marriage, or adoption." ; obo:IAO_0000117 "MIABIS", "Sarah Bost" ; a owl:Class ; rdfs:label "genealogical record"@en ; rdfs:subClassOf obo:IAO_0000310 . obo:OBI_0002617 obo:IAO_0000111 "national registry"@en ; obo:IAO_0000112 "The Social Security Administration's Death Master File is a national registry in the United States." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An information content entity that contains information about a nationwide group of individuals." ; obo:IAO_0000117 "MIABIS", "Sarah Bost" ; obo:IAO_0000119 "MIABIS contributors" ; a owl:Class ; rdfs:label "national registry"@en ; rdfs:subClassOf obo:IAO_0000030 . obo:OBI_0002618 obo:IAO_0000111 "national biomedical registry"@en ; obo:IAO_0000112 "The Care Register for Health Care, maintained by the Finnish National Institute for Health and Welfare, is a national biomedical registry." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A national registry that contains information about individuals that was accumulated for a biomedical purpose, such as diagnoses, treatments, or outcomes." ; obo:IAO_0000117 "MIABIS", "Sarah Bost" ; obo:IAO_0000119 "MIABIS contributors" ; a owl:Class ; rdfs:label "national biomedical registry"@en ; rdfs:subClassOf obo:OBI_0002617 . obo:OBI_0002619 obo:IAO_0000111 "site-directed mutagenesis" ; obo:IAO_0000112 "Site-directed mutagenesis was used to prepare mutants of the Hypoxia-inducible factor-1 (HIF-1) alpha subunit to investigate the role of certain amino acids in hypoxia. (PMID:12393189)" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An induced mutation in which a specific base change is programmed into the sequence of a synthetic primer." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000119 "url:https://www.ncbi.nlm.nih.gov/books/NBK21945/" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1058" ; a owl:Class ; rdfs:label "site-directed mutagenesis" ; rdfs:subClassOf obo:OBI_0001154 . obo:OBI_0002620 obo:IAO_0000111 "random mutagenesis" ; obo:IAO_0000112 "Error-prone PCR was used to introduce amino acid mutations to the cAMP receptor protein (CRP) of E. coli to investigate strain engineering to improve osmotolerance for industrial requirements. (PMID:22179860)" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An induced mutation that produces a random mutation, either by introducing the organism to mutagens, or through a process such as error-prone PCR." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000119 "PMID:15153637" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1058" ; a owl:Class ; rdfs:label "random mutagenesis" ; rdfs:subClassOf obo:OBI_0001154 . obo:OBI_0002621 obo:IAO_0000111 "reconstitution assay" ; obo:IAO_0000112 "\"In an attempt to define the mechanism of insulin-regulated glucose transporter 4 (Glut4) translocation, we have developed an in vitro reconstitution assay... insulin-induced Glut4 translocation can be reconstituted in vitro to a limited extent by using isolated membranes.\" (PMID:10611313)" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An assay in which a cellular process is replicated from the bottom-up using isolated components in order to observe how the components work together." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "reconstitution experiment" ; obo:IAO_0000119 "url:https://jcs.biologists.org/content/132/4/jcs227488" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1059" ; a owl:Class ; rdfs:label "reconstitution assay" ; rdfs:subClassOf obo:OBI_0000070, obo:OBI_0000471, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000059 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001285 obo:OBI_0002590 ) ] ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0009987 ] ] . obo:OBI_0002622 obo:IAO_0000111 "in vitro transcription reconstitution assay" ; obo:IAO_0000112 "An in vitro reconstituted mouse transcription system helped identify an NF-Y interacting promoter as essential for high-level expression from the R2 promoter. (PMID:11502214)" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A reconstitution assay in which RNA synthesis is investigated using RNA polymerase II transcription systems replicated in vitro from their base components." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000119 "PMID:9237163" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1059" ; a owl:Class ; rdfs:label "in vitro transcription reconstitution assay" ; rdfs:subClassOf obo:OBI_0002621, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0001172 ] ] . obo:OBI_0002623 obo:IAO_0000111 "whole metagenome sequencing assay" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A DNA sequencing assay that intends to provide information on the DNA sequences of multiple genomes (a metagenome) from different organisms present in the same input sample." ; obo:IAO_0000116 "Whole metagenome sequencing has been used to explore the composition and metabolic capability of communities of microbes found in the environment (e.g. in soil, water, etc.) and in humans and other species (e.g. in the gut, oral cavity, etc.)." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "WMS" ; obo:IAO_0000119 "Bjoern Peters", "Michelle Giglio" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1056" ; a owl:Class ; rdfs:label "whole metagenome sequencing assay" ; rdfs:subClassOf obo:OBI_0000626 . obo:OBI_0002624 obo:IAO_0000111 "case-control study design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that entails the creation of two types of roles, such that each participant under investigation bears one or the other. What distinguishes the two types of roles is an 'outcome', which is associated with participants that have the case role but not associated with participants that have the control role. A case-control study examines the hypothesis that the presence of the outcome in case participants is associated with an 'exposure' that is not associated with control participants." ; obo:IAO_0000117 "John Judkins, Bjoern Peters" ; obo:IAO_0000119 "Wikipedia, OBI" ; a owl:Class ; rdfs:label "case-control study design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0002625 obo:IAO_0000111 "gene knockdown" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A genetic transformation which reduces the expression of a specific gene or genes in an organism." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "gene knock-down" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Gene_knockdown" ; a owl:Class ; rdfs:label "gene knockdown" ; rdfs:subClassOf obo:OBI_0600043 . obo:OBI_0002626 obo:IAO_0000111 "RNAi gene knockdown" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A gene knockdown that silences genes through artificially-induced RNA interference. This is accomplished by introducing small double-stranded interfering RNA complementary to the target mRNA to be silenced, which is then cleaved by a ribonuclease." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "RNA interference gene knockdown" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Gene_knockdown" ; a owl:Class ; rdfs:label "RNAi gene knockdown" ; rdfs:subClassOf obo:OBI_0002625, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001152 ] . obo:OBI_0002627 obo:IAO_0000111 "ribosomal RNA-depleted RNA extract" ; obo:IAO_0000112 "Looking at the reads for each ribosomal RNA-depleted RNA extract, the vast majority align to protein coding genes based on the ENSEMBL annotation." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An extract of RNA which is produced through rRNA (ribosomal RNA) depletion (the removal of highly abundant rRNA species)." ; obo:IAO_0000117 "Dan Berrios" ; obo:IAO_0000119 "https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-018-4585-1"^^xsd:anyURI ; a owl:Class ; rdfs:label "ribosomal RNA-depleted RNA extract" ; rdfs:subClassOf obo:OBI_0000880 . obo:OBI_0002628 obo:IAO_0000111 "RNAi knockdown assay" ; obo:IAO_0000112 "\"Here, we described the development of RNAi by micro-injection of double-stranded RNA (dsRNA) in the pea aphid Acyrthosiphon pisum. Injection of dsRNA into whole aphid body induced the silencing of two marker genes with different expression patterns: the ubiquitously expressed Ap-crt genes encoding a calreticulin and the gut specific Ap-cath-L gene encoding a cathepsin-L.\" (PMID:17903251)" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A gene knockdown assay in which RNAi gene knockdown is used to disrupt gene transcripts." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "RNA interference knockdown assay", "RNAi gene knockdown assay" ; obo:IAO_0000119 "Rebecca Jackson" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1057" ; a owl:Class ; rdfs:label "RNAi knockdown assay" ; rdfs:subClassOf obo:OBI_0001672, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0002626 ] . obo:OBI_0002629 obo:IAO_0000111 "direct RNA sequencing assay" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An assay to study transcription through direct RNA sequence determination, without prior conversion of RNA molecules to cDNA." ; obo:IAO_0000117 "Dan Berrios" ; obo:IAO_0000118 "DRS", "direct RNA-seq" ; obo:IAO_0000119 "url:https://www.nature.com/articles/nature08390" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/874" ; obo:IAO_0000234 "jahilton" ; a owl:Class ; rdfs:label "direct RNA sequencing assay" ; rdfs:subClassOf obo:OBI_0001177 . obo:OBI_0002630 obo:IAO_0000111 "Illumina NovaSeq 6000" ; obo:IAO_0000112 "Genomic DNA of Xenophilus sp. E41 was extracted and sequenced using an Illumina NovaSeq 6000 system." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencer which is manufactured by the Illumina corporation, with two flow cells and an output of up to 6000 Gb (32-40 B reads per run). The sequencer utilizes synthesis technology and patterned flow cells to optimize throughput and even spacing of sequencing clusters." ; obo:IAO_0000117 "Dan Berrios" ; obo:IAO_0000118 "NovaSeq 6000" ; obo:IAO_0000119 "http://www.illumina.com/systems/sequencing-platforms/novaseq.html" ; a owl:Class ; rdfs:label "Illumina NovaSeq 6000" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000759 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002631 obo:IAO_0000111 "single-cell RNA sequencing assay" ; obo:IAO_0000112 "Single-cell RNA sequencing (scRNA-seq) assays provide the expression profiles of individual cells." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An RNA sequencing assay that uses RNA extracts as input that can be traced to a single cell of origin." ; obo:IAO_0000117 "Dan Berrios" ; obo:IAO_0000118 "scRNA-seq" ; obo:IAO_0000119 "Anna Maria Masci" ; a owl:Class ; rdfs:label "single-cell RNA sequencing assay" ; rdfs:subClassOf obo:OBI_0001271 . obo:OBI_0002632 obo:IAO_0000111 "PacBio Sequel" ; obo:IAO_0000112 "The cDNAs were sequenced on the PacBio Sequel platform." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencer built upon single molecule real-time sequencing technology, optimized for generation with long reads and high consensus accuracy, and manufactured by the Pacific Biosciences corporation" ; obo:IAO_0000117 "Bonita Lam", "Dan Berrios" ; obo:IAO_0000118 "Pacific BioSciences Sequel" ; obo:IAO_0000119 "http://www.pacb.com/products-and-services/pacbio-systems/sequel/" ; a owl:Class ; rdfs:label "PacBio Sequel" ; rdfs:subClassOf obo:OBI_0400103 . obo:OBI_0002633 obo:IAO_0000111 "PacBio Sequel II" ; obo:IAO_0000112 "The cDNAs were sequenced on the PacBio Sequel II platform." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencer built upon single molecule real-time sequencing technology, optimized for generation of highly accurate (\"HiFi\") long reads, and which is manufactured by the Pacific Biosciences corporation." ; obo:IAO_0000117 "Bonita Lam", "Dan Berrios" ; obo:IAO_0000118 "Pacific BioSciences Sequel II" ; obo:IAO_0000119 "http://www.pacb.com/products-and-services/pacbio-systems/sequel/" ; a owl:Class ; rdfs:label "PacBio Sequel II" ; rdfs:subClassOf obo:OBI_0400103 . obo:OBI_0002634 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific disease exacerbation resulting from the adoptive transfer of epitope specific antibodies or B cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An efficacy of B cell epitope intervention experiment that uses a disease exacerbation in vivo intervention experiment after adoptive transfer of epitope specific antibodies or B cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "disease exacerbation after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific disease exacerbation resulting from the adoptive transfer of epitope specific antibodies or B cells" ; rdfs:subClassOf obo:OBI_0001711, obo:OBI_0002677 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001188 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] ) ] . obo:OBI_0002635 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific disease reduction resulting from the adoptive transfer of epitope specific T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An efficacy of T cell epitope intervention experiment that detects a decrease in disease after adoptive transfer of epitope specfic T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "decreased disease after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific disease reduction resulting from the adoptive transfer of epitope specific T cells" ; rdfs:subClassOf obo:OBI_0001507, obo:OBI_0002676 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001190 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001174 obo:OBI_0003414 ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] ) ] . obo:OBI_0002636 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific disease reduction resulting from adoptive transfer of epitope specific antibodies or B cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An efficacy of B cell epitope intervention experiment that detects a decrease in disease after adoptive transfer of epitope specific antibodies or B cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "decreased disease after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific disease reduction resulting from adoptive transfer of epitope specific antibodies or B cells" ; rdfs:subClassOf obo:OBI_0001697, obo:OBI_0002677 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001190 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001174 obo:OBI_0003414 ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] ) ] . obo:OBI_0002637 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific protection from challenge resulting from the adoptive transfer of epitope specific T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An efficacy of T cell epitope intervention experiment that uses a epitope protection experiment after adoptive transfer of epitope specfic T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "protection from challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific protection from challenge resulting from the adoptive transfer of epitope specific T cells" ; rdfs:subClassOf obo:OBI_0002073, obo:OBI_0002676 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] ) ] . obo:OBI_0002638 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific protection from challenge resulting from adoptive transfer of epitope specific antibodies or B cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An efficacy of B cell epitope intervention experiment that uses a epitope protection experiment after adoptive transfer of epitope specific antibodies or B cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "protection from challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific protection from challenge resulting from adoptive transfer of epitope specific antibodies or B cells" ; rdfs:subClassOf obo:OBI_0001710, obo:OBI_0002677 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] ) ] . obo:OBI_0002639 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific protection from challenge resulting from the adoptive transfer of epitope specific T cells based on pathogen burden" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring T cell epitope specific protection from pathogen challenge resulting from the adoptive transfer of epitope specific antibodies or B cells using pathogen burden." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "pathogen burden after challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific protection from challenge resulting from the adoptive transfer of epitope specific T cells based on pathogen burden" ; rdfs:subClassOf obo:OBI_0001475, obo:OBI_0003470, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000712 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001174 obo:OBI_0003414 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] . obo:OBI_0002640 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific protection from challenge resulting from the adoptive transfer of epitope specific antibodies or B cells based on pathogen burden" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring B cell epitope specific protection from pathogen challenge resulting from the adoptive transfer of epitope specific antibodies or B cells using pathogen burden." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "pathogen burden after challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific protection from challenge resulting from the adoptive transfer of epitope specific antibodies or B cells based on pathogen burden" ; rdfs:subClassOf obo:OBI_0002051, obo:OBI_0003475, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000712 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001174 obo:OBI_0003414 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] . obo:OBI_0002641 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific protection from other challenge resulting from the adoptive transfer of epitope specific T cells based on survival" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring T cell epitope specific protection from other challenge resulting from the adoptive transfer of epitope specific T cells using survival." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "survival from other challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific protection from other challenge resulting from the adoptive transfer of epitope specific T cells based on survival" ; rdfs:subClassOf obo:OBI_0001492, obo:OBI_0003474, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001174 obo:OBI_0003414 ) ] ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:complementOf [ a owl:Class ; owl:unionOf (obo:OBI_0000712 obo:OBI_0003455 ) ] ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] . obo:OBI_0002642 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific protection from other challenge resulting from the adoptive transfer of epitope specific antibodies or B cells based on survival" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring B cell epitope specific protection from other challenge resulting from the adoptive transfer of epitope specific antibodies or B cells using survival." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "survival from other challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific protection from other challenge resulting from the adoptive transfer of epitope specific antibodies or B cells based on survival" ; rdfs:subClassOf obo:OBI_0001696, obo:OBI_0003479, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001174 obo:OBI_0003414 ) ] ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:complementOf [ a owl:Class ; owl:unionOf (obo:OBI_0000712 obo:OBI_0003455 ) ] ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] . obo:OBI_0002643 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific protection from challenge resulting from the adoptive transfer of epitope specific T cells based on tumor burden" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring T cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific T cells using tumor burden." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "tumor burden after challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific protection from challenge resulting from the adoptive transfer of epitope specific T cells based on tumor burden" ; rdfs:subClassOf obo:OBI_0001473, obo:OBI_0003472, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003455 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001174 obo:OBI_0003414 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] . obo:OBI_0002644 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific protection from challenge resulting from the adoptive transfer of epitope specific antibodies or B cells based on tumor burden" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring B cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific antibodies or B cells using tumor burden." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "tumor burden after challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific protection from challenge resulting from the adoptive transfer of epitope specific antibodies or B cells based on tumor burden" ; rdfs:subClassOf obo:OBI_0002052, obo:OBI_0003477, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003455 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001174 obo:OBI_0003414 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] . obo:OBI_0002645 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific tolerance induction resulting from the adoptive transfer of epitope specific T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An efficacy of T cell epitope intervention experiment that uses a tolerance induction intervention experiment after adoptive transfer of epitope specfic T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "tolerance after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific tolerance induction resulting from the adoptive transfer of epitope specific T cells" ; rdfs:subClassOf obo:OBI_0001324, obo:OBI_0002676 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001488 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0002517 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] ) ] . obo:OBI_0002646 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific tolerance induction resulting from the adoptive transfer of epitope specific antibodies or B cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An efficacy of B cell epitope intervention experiment that uses a tolerance induction intervention experiment after adoptive transfer of epitope specific antibodies or B cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "tolerance after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific tolerance induction resulting from the adoptive transfer of epitope specific antibodies or B cells" ; rdfs:subClassOf obo:OBI_0001693, obo:OBI_0002677 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001488 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0002514 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] ) ] . obo:OBI_0002647 obo:IAO_0000111 "Giemsa stain assay" ; obo:IAO_0000112 "Cytogenetics; the histopathological diagnosis of malaria and other parasites; differentiate nuclear and cytoplasmic morphology of the various blood cells like platelets, RBCs, WBCs" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that uses a Giemsa stain to characterize cells." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1093" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "Giemsa stain assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400169 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400169 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:CL_0000000 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000185 obo:OBI_0003368 ) ] ] . obo:OBI_0002648 obo:IAO_0000111 "individual organism specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen composed of an individual organism to be studied in an investigation." ; obo:IAO_0000117 "Person: Jie Zheng" ; obo:IAO_0000119 "EFO_0000542 individual" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1092" ; a owl:Class ; rdfs:label "individual organism specimen" ; rdfs:subClassOf obo:OBI_0100051, [ a owl:Restriction ; owl:onClass obo:OBI_0100026 ; owl:onProperty obo:RO_0002180 ; owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ] . obo:OBI_0002649 obo:IAO_0000111 "blood microbiology assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An organism detection assay that detects microorganisms in a blood specimen." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1064" ; a owl:Class ; rdfs:label "blood microbiology assay" ; rdfs:subClassOf obo:OBI_0003040, obo:OBI_0003498, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000655 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000655 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0100026 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100026 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000655 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000027 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0100026 ] ] . obo:OBI_0002650 obo:IAO_0000111 "biopsy" ; obo:IAO_0000112 "Biopsy of a potentially cancerous mole." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen collection that obtains a sample of tissue or cell from a living multicellular organism body for diagnostic purposes by means intended to be minimally invasive." ; obo:IAO_0000117 "Damion Dooley", "Nicole Vasilevsky" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Biopsy" ; a owl:Class ; rdfs:label "biopsy" ; rdfs:subClassOf obo:OBI_0600005, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000968 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0000465 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000873 ] . obo:OBI_0002651 obo:IAO_0000111 "image guided biopsy" ; obo:IAO_0000112 "Image-guided needle biopsy allows a doctor to biopsy suspicious areas that aren't readily seen or felt through skin, such as in a prostate gland." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A biopsy which uses an imaging procedure to guide a needle biopsy." ; obo:IAO_0000117 "Damion Dooley" ; obo:IAO_0000118 "image guided needle biopsy", "image-guided biopsy", "imaging guided biopsy" ; obo:IAO_0000119 "https://www.mayoclinic.org/diseases-conditions/cancer/in-depth/biopsy/art-20043922" ; a owl:Class ; rdfs:label "image guided biopsy" ; rdfs:subClassOf obo:OBI_0002654 . obo:OBI_0002652 obo:IAO_0000111 "computed tomography assisted biopsy" ; obo:IAO_0000112 "A CT Guided Biopsy is a procedure performed by a radiologist to obtain a small tissue sample through a needle." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A needle biopsy guided by real-time computed tomography (CT) scan images." ; obo:IAO_0000117 "Damion Dooley" ; obo:IAO_0000118 "CT Assisted Biopsy", "CT Guided Biopsy", "Computed Tomography Assisted Biopsy", "Computed Tomography-Guided Needle Biopsy" ; obo:IAO_0000119 "http://purl.obolibrary.org/obo/NCIT_C137909" ; a owl:Class ; rdfs:label "computed tomography assisted biopsy" ; rdfs:subClassOf obo:OBI_0002651, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000982 ] . obo:OBI_0002653 obo:IAO_0000111 "ultrasound-guided needle biopsy" ; obo:IAO_0000112 "An ultrasound-guided needle biopsy uses sound waves to help locate a nodule or abnormality within the thyroid." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A needle biopsy guided by ultrasound visualization." ; obo:IAO_0000117 "Damion Dooley" ; obo:IAO_0000119 "https://www.oncolink.org/cancer-treatment/procedures-diagnostic-tests/biopsy-procedures/ultrasound-guided-needle-biopsy" ; a owl:Class ; rdfs:label "ultrasound-guided needle biopsy" ; rdfs:subClassOf obo:OBI_0002651 . obo:OBI_0002654 obo:IAO_0000111 "needle biopsy" ; obo:IAO_0000112 "A needle biopsy is often used on suspicious breast lumps and enlarged lymph nodes that a doctor can feel through a patient's skin." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A biopsy that uses a hollow needle to extract cells." ; obo:IAO_0000117 "Damion Dooley" ; obo:IAO_0000119 "https://www.mayoclinic.org/tests-procedures/needle-biopsy/about/pac-20394749" ; a owl:Class ; rdfs:label "needle biopsy" ; rdfs:subClassOf obo:OBI_0002650, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000436 ] . obo:OBI_0002655 obo:IAO_0000111 "fine needle aspiration biopsy" ; obo:IAO_0000112 "A fine needle aspiration biopsy is commonly performed in order to test for cancer." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A biopsy that uses a thin needle to extract cells." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis, Jie Zheng" ; obo:IAO_0000118 "FNA", "FNAB" ; obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769667/" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "fine needle aspiration biopsy" ; rdfs:subClassOf obo:OBI_0002654 . obo:OBI_0002656 obo:IAO_0000111 "core needle biopsy" ; obo:IAO_0000112 "A core needle biopsy can remove more tissue than a fine needle biopsy, and therefore can provide more information about the cells and tissue removed." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A biopsy that uses a hollow tube to collect a core of tissue." ; obo:IAO_0000117 "Chris Stoeckert, Helena Ellis, Jie Zheng" ; obo:IAO_0000118 "CNB" ; obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769667/" ; obo:IAO_0000234 "NCI BBRB" ; a owl:Class ; rdfs:label "core needle biopsy" ; rdfs:subClassOf obo:OBI_0002654 . obo:OBI_0002657 obo:IAO_0000111 "surgical biopsy" ; obo:IAO_0000112 "Surgical biopsy may be required to collect hard-to-reach tissue." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A biopsy involving a surgical incision into an organism to access the biopsy material." ; obo:IAO_0000117 "Damion Dooley" ; obo:IAO_0000118 "excisional biopsy", "open biopsy" ; obo:IAO_0000119 "https://www.mayoclinic.org/diseases-conditions/cancer/in-depth/biopsy/art-20043922" ; a owl:Class ; rdfs:label "surgical biopsy" ; rdfs:subClassOf obo:OBI_0002650 . obo:OBI_0002660 obo:IAO_0000111 "abdominal wall fat pad biopsy" ; obo:IAO_0000112 "The makeup of fat in the abdominal wall can be investigated by fat biopsy." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A biopsy involving the collection of a small part of the abdominal wall fat pad." ; obo:IAO_0000117 "Nicole Vasilevsky, Damion Dooley" ; obo:IAO_0000118 "abdominal wall biopsy", "fat biopsy" ; obo:IAO_0000119 "https://www.ucsfbenioffchildrens.org/tests/003841.html" ; a owl:Class ; rdfs:label "abdominal wall fat pad biopsy" ; rdfs:subClassOf obo:OBI_0002650, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0010414 ] . obo:OBI_0002661 obo:IAO_0000111 "tail biopsy" ; obo:IAO_0000112 "A mouse tail biopsy was performed to collect material for DNA extraction." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A biopsy involving the collection of the tip of a mamallian tail." ; obo:IAO_0000117 "Nicole Vasilevsky, Damion Dooley" ; obo:IAO_0000118 "snip" ; obo:IAO_0000119 "http://web.jhu.edu/animalcare/policies/Tail%20Biopsy%20of%20Mice.pdf" ; a owl:Class ; rdfs:label "tail biopsy" ; rdfs:subClassOf obo:OBI_0002650, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0002415 ] . obo:OBI_0002662 obo:IAO_0000111 "bone marrow biopsy" ; obo:IAO_0000112 "A bone marrow biopsy removes bone with the marrow inside to look at under a microscope" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A biopsy where a small amount of bone and a small amount of fluid and bone marrow are collected." ; obo:IAO_0000117 "Nicole Vasilevsky" ; obo:IAO_0000119 "http://www.webmd.com/cancer/bone-marrow-aspiration-and-biopsy" ; a owl:Class ; rdfs:label "bone marrow biopsy" ; rdfs:subClassOf obo:OBI_0002650, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0002371 ] . obo:OBI_0002663 obo:IAO_0000111 "skinpunch biopsy" ; obo:IAO_0000112 "A three or four millimeter punch is used in s skinpunch biopsy proceedure." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A biopsy that involves the collection of a cylinder of skin (including epidermis, dermis and superficial fat) using a punch tool." ; obo:IAO_0000117 "Nicole Vasilevsky" ; obo:IAO_0000118 "punch biopsy; skin biopsy" ; obo:IAO_0000119 "http://healthlibrary.epnet.com/GetContent.aspx?token=b93d114e-5009-4f6a-9917-6c594254fcc7&chunkiid=14861" ; a owl:Class ; rdfs:label "skinpunch biopsy" ; rdfs:subClassOf obo:OBI_0002650, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0002199 ] . obo:OBI_0002664 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific interleukin-15 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects interleukin-15 production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-15 release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific interleukin-15 production by T cells" ; rdfs:subClassOf obo:OBI_0001292, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032618 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002665 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific interleukin-16 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects interleukin-16 production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-16 release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific interleukin-16 production by T cells" ; rdfs:subClassOf obo:OBI_0001280, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032619 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002666 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific induction of hypersensitivity resulting from the adoptive transfer of epitope specific antibodies or B cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An efficacy of B cell epitope intervention experiment that detects a hypersensitivity response by monitoring skin reactions after adoptive transfer of epitope specific antibodies or B cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "hypersensitivity after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific induction of hypersensitivity resulting from the adoptive transfer of epitope specific antibodies or B cells" ; rdfs:subClassOf obo:OBI_0001694, obo:OBI_0002677 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001178 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0002524 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] ) ] . obo:OBI_0002667 obo:IAO_0000111 "in vivo skin test assay measuring T cell epitope specific type IV hypersensitivity resulting from the adoptive transfer of epitope specific T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An efficacy of T cell epitope intervention experiment that detects epitope specific type IV hypersensitivity after adoptive transfer of epitope specfic T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "type IV hypersensitivity (DTH) after adoptive transfer|in vivo skin test" ; a owl:Class ; rdfs:label "in vivo skin test assay measuring T cell epitope specific type IV hypersensitivity resulting from the adoptive transfer of epitope specific T cells" ; rdfs:subClassOf obo:OBI_0001348, obo:OBI_0002676 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001178 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001806 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] ) ] . obo:OBI_0002668 obo:IAO_0000111 "in vivo assay measuring epitope specific proliferation of T cells resulting from the adoptive transfer of epitope specific T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific proliferation assay that is performed in vivo after adoptive transfer of epitope specfic T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "proliferation after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring epitope specific proliferation of T cells resulting from the adoptive transfer of epitope specific T cells" ; rdfs:subClassOf obo:OBI_0002070, obo:OBI_0002676 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042098 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] ) ] . obo:OBI_0002669 obo:IAO_0000111 "assay measuring epitope specific helper T cell enhancement of a B cell mediated immune response resulting from the adoptive transfer of epitope specific T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific helper activity assay that detects the ability of a T cell epitope to enhance an antibody response after adoptive transfer of epitope specfic T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "antibody help after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "assay measuring epitope specific helper T cell enhancement of a B cell mediated immune response resulting from the adoptive transfer of epitope specific T cells" ; rdfs:subClassOf obo:OBI_0001228, obo:OBI_0002676 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0035399 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] ) ] . obo:OBI_0002670 obo:IAO_0000111 "assay measuring epitope specific helper T cell enhancement of a T cell mediated immune response resulting from the adoptive transfer of epitope specific T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific helper activity assay that detects the ability of a T cell epitope to enhance a T cell response after adoptive transfer of epitope specfic T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "T cell help after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "assay measuring epitope specific helper T cell enhancement of a T cell mediated immune response resulting from the adoptive transfer of epitope specific T cells" ; rdfs:subClassOf obo:OBI_0001263, obo:OBI_0002676 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0035398 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] ) ] . obo:OBI_0002671 obo:IAO_0000111 "in vivo assay measuring epitope specific T cell killing resulting from the adoptive transfer of epitope specific T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo cell killing assay that detects the killing of an antigen presenting cell (APC) by a T cell whose TCR recognizes an epitope presented by the APC after adoptive transfer of epitope specific T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "cytotoxicity after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring epitope specific T cell killing resulting from the adoptive transfer of epitope specific T cells" ; rdfs:subClassOf obo:OBI_0001392, obo:OBI_0002676 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000883 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001913 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] ) ] . obo:OBI_0002672 obo:IAO_0000111 "ELISA measuring epitope specific perforin release by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects epitope specific perforin release by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "perforin release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific perforin release by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001497 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0003317 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0002673 obo:IAO_0000111 "enrichment culture medium" ; obo:IAO_0000112 "Selenite broth is an enrichment culture medium used to selectively isolate Salmonella species." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A culture medium that is designed to favor the growth of a particular microorganism or cells over others, enriching a sample for the microorganism or cells of interest." ; obo:IAO_0000117 , ; obo:IAO_0000118 "isolation medium" ; obo:IAO_0000119 ; dc:date "2020-03-08T22:04:07Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "enrichment culture medium" ; rdfs:seeAlso ; rdfs:subClassOf obo:OBI_0000079 . obo:OBI_0002674 obo:IAO_0000111 "case series study design" ; obo:IAO_0000112 "PMID: 22213493" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A study design that samples only subjects who have experienced a particular event (outcome or exposure). Such a design, in contrast to a cohort study, does not permit calculation of absolute risk as non-case subjects are not included." ; obo:IAO_0000117 "http://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/22213493" ; a owl:Class ; rdfs:label "case series design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0002675 obo:IAO_0000111 "massively parallel reporter assay" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An assay in which multiplexing the construction and interrogation of larger libraries of reporter constructs allows measurement of the transcriptional regulatory activities of thousands to hundreds of thousands of DNA sequences." ; obo:IAO_0000117 "Damion Dooley" ; obo:IAO_0000118 "MPRA" ; obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364389/" ; a owl:Class ; rdfs:label "massively parallel reporter assay" ; rdfs:subClassOf obo:OBI_0002082 . obo:OBI_0002676 obo:IAO_0000111 "in vivo assay measuring a T cell epitope specific response after adoptive transfer of epitope specific T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An efficacy of T cell epitope intervention experiment that is performed after adoptive transfer of epitope specfic T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "in vivo response after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring a T cell epitope specific response after adoptive transfer of epitope specific T cells" ; rdfs:subClassOf obo:OBI_0001484 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] ) ] . obo:OBI_0002677 obo:IAO_0000111 "in vivo assay measuring a B cell epitope specific response after adoptive transfer of epitope specific antibodies or B cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An efficacy of B cell epitope intervention experiment that is performed after adoptive transfer of epitope specific antibodies or B cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "in vivo response after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring a B cell epitope specific response after adoptive transfer of epitope specific antibodies or B cells" ; rdfs:subClassOf obo:OBI_0001698 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] ) ] . obo:OBI_0002678 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific disease exacerbation resulting from the adoptive transfer of epitope specific T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An efficacy of T cell epitope intervention experiment that uses a disease exacerbation in vivo intervention experiment after adoptive transfer of epitope specfic T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "disease exacerbation after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific disease exacerbation resulting from the adoptive transfer of epitope specific T cells" ; rdfs:subClassOf obo:OBI_0001467, obo:OBI_0002676 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001188 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] ) ] . obo:OBI_0002679 obo:IAO_0000111 "vacuum-assisted biopsy needle" ; obo:IAO_0000112 "Vacuum-assisted biopsy needles come in two varieties: a non-tethered design and a needle design requiring tethering cable to a vacuum source." ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "A core biopsy needle integrated with a vacuum system which facilitates the collection of specimen material." ; obo:IAO_0000117 "Damion Dooley" ; obo:IAO_0000119 "https://www.researchgate.net/publication/330227873" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1163" ; a owl:Class ; rdfs:label "vacuum-assisted biopsy needle" ; rdfs:subClassOf obo:OBI_0000436, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000383 ] . obo:OBI_0002680 obo:IAO_0000111 "pseudovirus entry assay" ; obo:IAO_0000112 "“Inhibition of MERS-CoV-spike-mediated pseudovirus entry by the HKU4 S1 domain “ (from https://doi.org/10.1073/pnas.1405889111); “protease treatment did not enhance pseudotype entry in the absence of host receptor “; “bat-derived cell lines derived from other species were infected with VSV-reporter particles pseudotyped with chimeric spikes and luciferase was measured as readout for cell entry” (from https://doi.org/10.1038/s41564-020-0688-y) ; “teicoplanin could inhibit the entry of HIV-1-2019-nCoV-S pseudoviruses with the IC50 value of 1.66 uM” (from https://doi.org/10.1101/2020.02.05.935387)" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An assay that measures the entry in target cells of reporter viral particles that express an envelope protein of a different virus of interest." ; obo:IAO_0000117 "Thomas Lemberger" ; obo:IAO_0000118 "pseudotype cell entry", "pseudotype entry", "pseudotyped particle cell entry assay", "pseudovirus cell entry" ; obo:IAO_0000119 "Figure 1c in https://doi.org/10.1038/s41564-020-0688-y or Materials & Method in https://www.pnas.org/content/111/34/12516" ; a owl:Class ; rdfs:label "pseudovirus entry assay" ; rdfs:subClassOf obo:OBI_0001187 . obo:OBI_0002681 obo:IAO_0000111 "glass bottle" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A container with a narrow neck that is made of glass." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "glass bottle" ; rdfs:subClassOf obo:OBI_0000967, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000370 ] . obo:OBI_0002682 obo:IAO_0000111 "glass bottle coated with insecticides" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A glass bottle that coated with material designed to control insects." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "glass bottle coated with insecticides" ; rdfs:subClassOf obo:OBI_0002681, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000370 ] . obo:OBI_0002683 obo:IAO_0000111 "short interspersed nuclear elements polymerase chain reaction" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A polymerase chain reaction that amplifies short interspersed nuclear elements (SINEs)." ; obo:IAO_0000117 "Jie Zheng" ; obo:IAO_0000118 "short interspersed elements PCR" ; obo:IAO_0000119 "PMID: 12711348" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "short interspersed nuclear elements polymerase chain reaction" ; rdfs:subClassOf obo:OBI_0000415 . obo:OBI_0002684 obo:IAO_0000111 "nested polymerase chain reaction" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A polymerase chain reaction with modification intended to reduce non-specific binding in products due to the amplification of unexpected primer binding sites. The nested polymerase chain reaction (PCR) involves the use of two primer sets and two successive PCR reactions. The first set of primers are designed to anneal to sequences upstream from the second set of primers and are used in an initial PCR reaction." ; obo:IAO_0000117 "Jie Zheng" ; obo:IAO_0000118 "nested PCR", "nested-PCR" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Nested_polymerase_chain_reaction" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "nested polymerase chain reaction" ; rdfs:subClassOf obo:OBI_0000415 . obo:OBI_0002685 obo:IAO_0000111 "immunoelectrophoresis" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An electrophoresis that separates and characterize proteins based on reaction with antibodies." ; obo:IAO_0000117 "Jie Zheng" ; obo:IAO_0000118 "IEP" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Immunoelectrophoresis" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "immunoelectrophoresis" ; rdfs:subClassOf obo:OBI_0600053 . obo:OBI_0002686 obo:IAO_0000111 "counter current immunoelectrophoresis" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An electrophoresis in which antigen and antibody move in opposite directions and form precipitates in the area between the cells where they meet in concentrations of optimal proportions." ; obo:IAO_0000117 "Jie Zheng" ; obo:IAO_0000119 "http://www.ispybio.com/search/protocols/ie%20protocol2.pdf" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "counter current immunoelectrophoresis" ; rdfs:subClassOf obo:OBI_0600053 . obo:OBI_0002687 obo:IAO_0000111 "ligase detection reaction" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A linear amplification that uses a thermostable ligase to amplify a piece of DNA. Because the enzyme retains activity after multiple thermal cycles, the ligations may be repeated to linearly increase product." ; obo:IAO_0000117 "Jie Zheng" ; obo:IAO_0000118 "LDR" ; obo:IAO_0000119 "MIRO:20000103" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "ligase detection reaction" ; rdfs:subClassOf obo:OBI_0001494 . obo:OBI_0002688 obo:IAO_0000111 "loop-mediated isothermal amplification" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzymatic amplification in which a piece of DNA is amplified at a constant temperature of 60 - 65 degree C using either two or three sets of primers and a polymerase with high strand displacement activity in addition to a replication activity. This amplification does not need thermal cyclers and may be a low cost alternative to PCR." ; obo:IAO_0000117 "Jie Zheng" ; obo:IAO_0000118 "LAMP" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Loop-mediated_isothermal_amplification" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "loop-mediated isothermal amplification" ; rdfs:subClassOf obo:OBI_0600058 . obo:OBI_0002689 obo:IAO_0000111 "detection of pathogenic organisms objective" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism feature identification objective that aims to detect whether an organism contains pathogenic organisms." ; obo:IAO_0000117 "Jie Zheng" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "detection of pathogenic organisms objective" ; rdfs:subClassOf obo:OBI_0000268 . obo:OBI_0002690 obo:IAO_0000111 "insecticide resistance detection objective" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism feature identification objective that aims to detect insecticide resistance of an insect." ; obo:IAO_0000117 "Jie Zheng" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance detection objective" ; rdfs:subClassOf obo:OBI_0000268 . obo:OBI_0002691 obo:IAO_0000111 "arthropod meal of blood specimen" ; obo:IAO_0000112 "A specimen used in a blood meal assay to determine what is the source of blood ingested by a mosquito." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen of the blood ingested by an arthropod." ; obo:IAO_0000116 "The mosquito feeds on a human for example, ingests the blood of the human, this blood is then taken from the tummy of a mosquito and a PCR may be run on this specimen to identify that the mosquito definitely fed on a human." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng" ; obo:IAO_0000118 "blood meal" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "arthropod meal of blood specimen" ; rdfs:subClassOf obo:OBI_0100051 . obo:OBI_0002692 obo:IAO_0000111 "polymerase chain reaction assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that uses polymerase chain reaction technique to amplify DNA." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "polymerase chain reaction assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000415 ] ) ] . obo:OBI_0002693 obo:IAO_0000111 "restriction fragment length polymorphism assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that uses digestion of DNA with specific restriction enzymes followed by gel electropheresis to detect differences in the sizes of the generated fragments that are due to genetic differences (polymorphisms) in homologous sequences." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "RFLP", "restriction fragment length polymorphism", "restriction fragment length polymorphism analysis" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Restriction_fragment_length_polymorphism" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "restriction fragment length polymorphism assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001121 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001121 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000732 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000732 ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0600055 ] . obo:OBI_0002694 obo:IAO_0000111 "DNA fingerprinting assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay to identify a specific individual organism from a DNA specimen by looking at unique patterns in their DNA." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "DNA finger printing", "DNA fingerprint", "DNA fingerprinting", "DNA profiling" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "DNA fingerprinting assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0002695 obo:IAO_0000111 "insecticide resistance assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that aims to detect the presence and/or frequency of resistance to insecticides in an organism or organism population." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "resistance identification/monitoring" ; obo:IAO_0000119 "MIRO:20000001" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] ) ] . obo:OBI_0002696 obo:IAO_0000111 "insecticide resistance by monitoring known mutations assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance assay that detects, in a population, presence and frequency of mutant alleles for previously characterized mutations with insecticide resistance phenotypes." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "monitoring known mutations" ; obo:IAO_0000119 "MIRO:20000096" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance by monitoring known mutations assay" ; rdfs:subClassOf obo:OBI_0002695, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002697 obo:IAO_0000111 "insecticide resistance by detecting enzyme activity assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance assay that is based on determination the catalytic activity of an enzyme associated with insecticide resistance phenotypes." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "metabolic resistance assay" ; obo:IAO_0000119 "MIRO:20000003" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance by detecting enzyme activity assay" ; rdfs:subClassOf obo:OBI_0002695, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0003824 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002698 obo:IAO_0000111 "insecticide resistance bioassay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance assay that is typically conducted to measure the effects of a substance on a living organism." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "bioassay" ; obo:IAO_0000119 "MIRO:20000058" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance bioassay" ; rdfs:subClassOf obo:OBI_0002695, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002699 obo:IAO_0000111 "insecticide resistance by detecting alpha esterase activity assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance by detecting enzyme activity assay that measures activity of alpha esterase." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "alpha esterase activity assay" ; obo:IAO_0000119 "IRO:0000149" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance by detecting alpha esterase activity assay" ; rdfs:subClassOf obo:OBI_0002697, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0016788 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002700 obo:IAO_0000111 "insecticide resistance by detecting beta esterase activity assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance by detecting enzyme activity assay that measures activity of beta esterase." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "beta esterase activity assay" ; obo:IAO_0000119 "IRO:0000150" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance by detecting beta esterase activity assay" ; rdfs:subClassOf obo:OBI_0002697, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0016788 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002701 obo:IAO_0000111 "insecticide resistance by detecting acetylcholinesterase activity assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance by detecting enzyme activity assay that measures activity of acetylcholinesterase." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "AChE activity assay", "AChE assay", "acetylcholinesterase assay" ; obo:IAO_0000119 "MIRO:20000010", "MIRO:20000084", "MIRO:20000086" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance by detecting acetylcholinesterase activity assay" ; rdfs:subClassOf obo:OBI_0002697, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0003990 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002702 obo:IAO_0000111 "insecticide resistance by detecting glutathione S-transferase activity assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance by detecting enzyme activity assay that measures activity of glutathione S-transferase (GST)." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "GST related assay" ; obo:IAO_0000119 "MIRO:20000083" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance by detecting glutathione S-transferase activity assay" ; rdfs:subClassOf obo:OBI_0002697, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0004364 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002703 obo:IAO_0000111 "insecticide resistance by detecting carboxylic ester hydrolase activity assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance by detecting enzyme activity assay that measures activity of carboxylic ester hydrolase using p-nitrophenyl acetate as a substrate." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "pNPA assay" ; obo:IAO_0000119 "MIRO:20000019" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance by detecting carboxylic ester hydrolase activity assay" ; rdfs:subClassOf obo:OBI_0002697, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0052689 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002704 obo:IAO_0000111 "insecticide resistance by detecting mixed-function oxidase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance by detecting enzyme activity assay that measures whether mixed-function oxidase activity present." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "mixed-function oxidase assay" ; obo:IAO_0000119 "MIRO:20000062" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance by detecting mixed-function oxidase assay" ; rdfs:subClassOf obo:OBI_0002697, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002705 obo:IAO_0000111 "direct insecticide resistance bioassay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance bioassay without the use of any synergist." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "direct bioassay" ; obo:IAO_0000119 "MIRO:20000044" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "direct insecticide resistance bioassay" ; rdfs:subClassOf obo:OBI_0002698, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002706 obo:IAO_0000111 "topical application insecticide resistance bioassay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance bioassay by adding insecticide directly to the thorax of the insect." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "topical application assay" ; obo:IAO_0000119 "IRO:0000155" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "topical application insecticide resistance bioassay" ; rdfs:subClassOf obo:OBI_0002698, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002707 obo:IAO_0000111 "direct insecticide resistance diagnostic assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A direct insecticide resistance assay that at preset insecticide dosage scoring mortality to determine resistance of a population." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "diagnostic test" ; obo:IAO_0000119 "MIRO:20000075" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "direct insecticide resistance diagnostic assay" ; rdfs:subClassOf obo:OBI_0002705, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002708 obo:IAO_0000111 "insecticide resistance dose response assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A direct insecticide resistance assay in which an insect population is exposed to a range of insecticide dosage scoring mortality to determine resistance." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "dose response test" ; obo:IAO_0000119 "MIRO:20000076" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance dose response assay" ; rdfs:subClassOf obo:OBI_0002705, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002709 obo:IAO_0000111 "insecticide resistance time response assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A direct insecticide resistance assay to determine resistance as a consequence of the time of exposure to insecticide." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "time response test" ; obo:IAO_0000119 "MIRO:20000013" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance time response assay" ; rdfs:subClassOf obo:OBI_0002705, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002710 obo:IAO_0000111 "Centre for Disease Control and Prevention bottle bioassay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A direct insecticide resistance diagnostic assay performs in a glass bottle coated with insecticides for detecting resistance to insecticides in vector populations." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "CDC bottle bioassay" ; obo:IAO_0000119 "MIRO:20000009" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "Centre for Disease Control and Prevention bottle bioassay" ; rdfs:subClassOf obo:OBI_0002707, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0002682 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0002682 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002711 obo:IAO_0000111 "WHO cone kit diagnostic assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A direct insecticide resistance diagnostic assay uses WHO cone kit." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "cone DT" ; obo:IAO_0000119 "MIRO:20000039" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "WHO cone kit diagnostic assay" ; rdfs:subClassOf obo:OBI_0002707, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002712 obo:IAO_0000111 "WHO paper kit diagnostic assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A direct insecticide resistance diagnostic assay uses WHO paper kit." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "WHO paper kit DT" ; obo:IAO_0000119 "MIRO:20000041" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "WHO paper kit diagnostic assay" ; rdfs:subClassOf obo:OBI_0002707, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002713 obo:IAO_0000111 "WHO larvicide diagnostic assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A direct insecticide resistance diagnostic assay tests survival of larvae in a medium supplemented with insecticide." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "WHO larvicide DT" ; obo:IAO_0000119 "MIRO:20000049" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "WHO larvicide diagnostic assay" ; rdfs:subClassOf obo:OBI_0002707, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002714 obo:IAO_0000111 "insecticide resistance dose response by bottle assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance dose response assay that performs in a glass bottle coated with insecticides." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "bottle bioassay DR test" ; obo:IAO_0000119 "MIRO:20000011" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance dose response by bottle assay" ; rdfs:subClassOf obo:OBI_0002708, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0002682 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0002682 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002715 obo:IAO_0000111 "insecticide resistance dose response by survival of larvae assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance dose response assay that tests survival of larvae in a medium supplemented with insecticide." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "WHO larvicide DR test" ; obo:IAO_0000119 "MIRO:20000050" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance dose response by survival of larvae assay" ; rdfs:subClassOf obo:OBI_0002708, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002716 obo:IAO_0000111 "insecticide resistance dose response by WHO paper kit assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance dose response assay using WHO paper kit." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "WHO paper kit DR test" ; obo:IAO_0000119 "MIRO:20000048" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance dose response by WHO paper kit assay" ; rdfs:subClassOf obo:OBI_0002708, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002717 obo:IAO_0000111 "insecticide resistance time response by bottle assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance time response assay that is performed in a glass bottle coated with insecticides, with the presence of a synergist." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "bottle bioassay TR test" ; obo:IAO_0000119 "MIRO:20000030" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance time response by bottle assay" ; rdfs:subClassOf obo:OBI_0002709, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0002682 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0002682 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002718 obo:IAO_0000111 "insecticide resistance time response by WHO paper kit assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance time response assay using WHO paper kit, with the presence of a synergist." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "WHO paper kit TR test" ; obo:IAO_0000119 "MIRO:20000036" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance time response by WHO paper kit assay" ; rdfs:subClassOf obo:OBI_0002709, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002719 obo:IAO_0000111 "insecticide resistance by amplification refractory mutation system assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance by monitoring known mutations assay that detects any mutation involving single base changes or small deletions using amplification refractory mutation system (ARMS). The ARMS is based on the use of sequence-specific PCR primers that allow amplification of test DNA only when the target allele is contained within the sample. Following an ARMS reaction the presence or absence of a PCR product is diagnostic for the presence or absence of the target allele. It can be used to analyze human genomic DNA for one or more mutations." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "ARMS", "Amplification Refractory Mutation System" ; obo:IAO_0000119 "IRO:0000006", "PMID: 18428319" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance by amplification refractory mutation system assay" ; rdfs:subClassOf obo:OBI_0002692, obo:OBI_0002696, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000415 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002720 obo:IAO_0000111 "insecticide resistance by primer introduced restriction analysis PCR assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance by monitoring known mutations assay that detects Single Nucleotide Polymorphisms (SNPs) using PCR technique and mismatched primers that is close to the mutation of interest and digested the PCR productions using restriction enzymes." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "PIRA-PCR", "Primer Introduced Restriction Analysis PCR", "polymerase chain reaction-primer-introduced restriction analysis" ; obo:IAO_0000119 "IRO:0000007", "PMID: 8339229" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance by primer introduced restriction analysis PCR assay" ; rdfs:subClassOf obo:OBI_0002692, obo:OBI_0002696, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000415 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0600050 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002721 obo:IAO_0000111 "insecticide resistance by nested polymerase chain reaction assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance by monitoring known mutations assay that detects gene mutation based on nested polymerase chain reaction technique." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "gene mutation detection by nested PCR" ; obo:IAO_0000119 "IRO:0000127" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance by nested polymerase chain reaction assay" ; rdfs:subClassOf obo:OBI_0002692, obo:OBI_0002696, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0002684 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002722 obo:IAO_0000111 "insecticide resistance by ligase detection reaction assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance assay that is based on monitoring known mutations using ligase detection reaction exquisitely discriminate between a mismatched and complementary DNA helix." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000119 "MIRO:20000103" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance by ligase detection reaction assay" ; rdfs:subClassOf obo:OBI_0002696, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0002687 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002723 obo:IAO_0000111 "insecticide resistance by ligase detection reaction-fluorescent microsphere assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance by ligase detection reaction assay that uses fluorescently labeled conserved probes in ligase detection reaction." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "gene mutation detection by LDR-FMA", "ligase detection reaction-fluorescent microsphere assay" ; obo:IAO_0000119 "IRO:0000151" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance by ligase detection reaction-fluorescent microsphere assay" ; rdfs:subClassOf obo:OBI_0002722, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0002687 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002724 obo:IAO_0000111 "insecticide resistance by PCR amplification of specific alleles assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance assay that is based on monitoring known mutations by PCR amplification of specific alleles to detect polymorphic or mutant alleles." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "PASA", "PCR amplification of specific alleles", "allele-specific amplification and amplification refractory mutation system" ; obo:IAO_0000119 "PMID: 1734929" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance by PCR amplification of specific alleles assay" ; rdfs:subClassOf obo:OBI_0002692, obo:OBI_0002696, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000415 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002725 obo:IAO_0000111 "insecticide resistance by fluorogenic PCR assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance assay that is based on monitoring known mutations by PCR technique that uses target specific probes labeled with fluorogenic chromophores to detect gene mutation." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000119 "MIRO:20000102" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance by fluorogenic PCR assay" ; rdfs:subClassOf obo:OBI_0002692, obo:OBI_0002696, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000415 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002726 obo:IAO_0000111 "insecticide resistance by PCR-RFLP assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance by monitoring known mutations assay based on restriction fragment length polymorphism assay." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "PCR-RFLP" ; obo:IAO_0000119 "MIRO:20000113" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance by PCR-RFLP assay" ; rdfs:subClassOf obo:OBI_0002692, obo:OBI_0002696, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000415 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002693 obo:OBI_0003368 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002727 obo:IAO_0000111 "insecticide resistance by short interspersed elements PCR assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An insecticide resistance assay that is based on monitoring known mutations by PCR amplification of short interspersed elements (SINEs)." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "Short Interspersed Elements PCR" ; obo:IAO_0000119 "IRO:0000013" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance by short interspersed elements PCR assay" ; rdfs:subClassOf obo:OBI_0002692, obo:OBI_0002696, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000415 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002690 ] . obo:OBI_0002728 obo:IAO_0000111 "pathogen detection assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that detects pathogens." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "pathogen detection method" ; obo:IAO_0000119 "IRO:0000137" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "pathogen detection assay" ; rdfs:subClassOf obo:OBI_0003498 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003498 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:IDO_0000528 ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002689 ] ) ] . obo:OBI_0002729 obo:IAO_0000111 "VectorTest assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathogen detection assay that identifies the presence or absence of specific peptide epitopes of circumsporozoite (CS) protein of the most important Plasmodium falciparum and two strains (variants 210 and 247) of the more widespread Plasmodium vivax using a dipstick wicking test strip." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "VectorTest" ; obo:IAO_0000119 "IRO:0000138" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "VectorTest assay" ; rdfs:subClassOf obo:OBI_0002728, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:IDO_0000528 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002689 ] . obo:OBI_0002730 obo:IAO_0000111 "pathogen detection by Rapid Analyte Measurement Platform assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathogen detection assay that is based on Rapid Analyte Measurement Platform (RAMP) technology to quantify immunologically active substances." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "Rapid Analyte Measurement Platform" ; obo:IAO_0000119 "IRO:0000164" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "pathogen detection by Rapid Analyte Measurement Platform assay" ; rdfs:subClassOf obo:OBI_0002728, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:IDO_0000528 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002689 ] . obo:OBI_0002731 obo:IAO_0000111 "pathogen detection by loop-mediated isothermal amplification assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pathogen detection assay that is based on loop-mediated isothermal amplification." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "Loop-mediated isothermal amplification" ; obo:IAO_0000119 "IRO:0000165" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "pathogen detection by loop-mediated isothermal amplification assay" ; rdfs:subClassOf obo:OBI_0002728, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0002688 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:IDO_0000528 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0002689 ] . obo:OBI_0002732 obo:IAO_0000111 "blood meal assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that analyzes the specimen taken from blood meal fed organism, such as insect." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "blood meal analysis" ; obo:IAO_0000119 "IRO:0000135" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "blood meal assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0002691 ] ) ] . obo:OBI_0002733 obo:IAO_0000111 "blood meal by counter current immunoelectrophoresis assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A blood meal assay that uses a counter current immunoelectrophoresis technique." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "CIE", "countercurrent immunoelectrophoresis" ; obo:IAO_0000119 "IRO:0000136" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "blood meal by counter current immunoelectrophoresis assay" ; rdfs:subClassOf obo:OBI_0002732, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0002686 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0002691 ] . obo:OBI_0002734 obo:IAO_0000111 "DNA based blood meal finger printing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA fingerprinting assay that uses DNA extracted from blood meal fed organism, such as insect." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "DNA based blood meal finger printing" ; obo:IAO_0000119 "VEuPathDB", "VSMO:0001307" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "DNA based blood meal finger printing assay" ; rdfs:subClassOf obo:OBI_0002694, obo:OBI_0002732, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0002691 ] . obo:OBI_0002735 obo:IAO_0000111 "organism detection by size assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that is based on the size of organism." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "by size" ; obo:IAO_0000119 "IRO:0000145" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "organism detection by size assay" ; rdfs:subClassOf obo:OBI_0003498 . obo:OBI_0002736 obo:IAO_0000111 "organism detection by cross mating assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that is based on genetic crossings between specimens collected in the field to determine whether fertile progeny is produced." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "cross mating experiment" ; obo:IAO_0000119 "MIRO:30000036" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "organism detection by cross mating assay" ; rdfs:subClassOf obo:OBI_0003498 . obo:OBI_0002737 obo:IAO_0000111 "organism detection by cytological chromosome examination assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that is based on analysis of polytene chromosomes through cytological examination of the banding pattern of the species." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "cytological chromosome examination" ; obo:IAO_0000119 "MIRO:30000037" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "organism detection by cytological chromosome examination assay" ; rdfs:subClassOf obo:OBI_0003498 . obo:OBI_0002738 obo:IAO_0000111 "organism detection by isoenzyme electrophoresis assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that is based on electrophoresis to determine the isozymes that are present in a specific population to determine the species." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "isoenzyme electrophoresis" ; obo:IAO_0000119 "MIRO:30000038" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "organism detection by isoenzyme electrophoresis assay" ; rdfs:subClassOf obo:OBI_0003498, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0600053 ] . obo:OBI_0002739 obo:IAO_0000111 "organism detection by morphological examination assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that is based on examination of morphology and the use of specific taxonomic keys to determine the species of the specimen." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "morphological examination" ; obo:IAO_0000119 "MIRO:30000039" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "organism detection by morphological examination assay" ; rdfs:subClassOf obo:OBI_0003498 . obo:OBI_0002740 obo:IAO_0000111 "organism detection by PCR assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that is based on PCR." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "PCR-based species identification" ; obo:IAO_0000119 "MIRO:30000040" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "organism detection by PCR assay" ; rdfs:subClassOf obo:OBI_0002692, obo:OBI_0003498, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000415 ] . obo:OBI_0002741 obo:IAO_0000111 "organism detection by specific DNA hybridization assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that is based on DNA hybrdization." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "species specific DNA hybridization" ; obo:IAO_0000119 "MIRO:30000041" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "organism detection by specific DNA hybridization assay" ; rdfs:subClassOf obo:OBI_0003498, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0302903 ] . obo:OBI_0002742 obo:IAO_0000111 "organism detection by salinity tolerance assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay of mosquito species that is on the basis of mosquito survival depending on the salt concentration in the water used to lay their eggs to differentiate between morphologically very similar species." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "salinity tolerance tests" ; obo:IAO_0000119 "MIRO:30000042" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1117" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "organism detection by salinity tolerance assay" ; rdfs:subClassOf obo:OBI_0003498 . obo:OBI_0002743 obo:IAO_0000111 "molecular label role"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A reagent role inhering in a molecular entity intended to associate with some molecular target to serve as a proxy for the presence, abundance, or location of this target in a detection of molecular label assay."@en ; obo:IAO_0000116 """MHB (9-29-13): 'molecular label role' imported from the Reagent Ontology and replaced OBI:OBI_0000140 (label role). JZ (3-30-20): discussed on the OBI call. Since the REO was never actually registered, we decided to adopt the term into OBI and replaced REO_0000171 by newly assigned ID: OBI:0002743.""" ; obo:IAO_0000117 "Group: OBI"@en ; obo:IAO_0000118 "molecular tracer role"@en ; obo:IAO_0000119 "OBI developer call, 3-12-12" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1135"@en ; a owl:Class ; rdfs:label "molecular label role"@en ; rdfs:subClassOf obo:OBI_0000086 . obo:OBI_0002744 obo:IAO_0000111 "molecular label"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A molecular reagent intended to associate with some molecular target to serve as a proxy for the presence, abundance, or location of this target in a detection of molecular label assay"@en ; obo:IAO_0000116 "JZ (3-30-20): discussed on the OBI call. Since the REO was never actually registered, we decided to adopt the term into OBI and replaced OBI:0002744 by newly assigned ID: OBI:0002744."@en ; obo:IAO_0000117 "Group: OBI"@en ; obo:IAO_0000118 "molecular tracer"@en ; obo:IAO_0000119 "OBI developer call, 3-12-12" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1135"@en ; a owl:Class ; rdfs:label "molecular label"@en ; rdfs:subClassOf obo:CHEBI_23367, obo:OBI_0001879 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CHEBI_23367 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0002743 ] ) ] . obo:OBI_0002745 obo:IAO_0000111 "vacuum-assisted biopsy" ; obo:IAO_0000112 "A vacuum assisted biopsy can remove an area of abnormal cells from breast tissue." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A biopsy performed with a needle augmented with a vacuum device." ; obo:IAO_0000117 "Damion Dooley" ; obo:IAO_0000118 "VAB" ; obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769667/" ; a owl:Class ; rdfs:label "vacuum-assisted biopsy" ; rdfs:subClassOf obo:OBI_0002654, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0002679 ] . obo:OBI_0002746 obo:IAO_0000111 "induced sputum specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A sputum specimen that is collected from an organism following its inhalation of a nebulized salt solution." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "PMC3297553" ; a owl:Class ; rdfs:label "induced sputum specimen" ; rdfs:subClassOf obo:OBI_0002508, [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0007311 ] ) ], [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] . obo:OBI_0002747 obo:IAO_0000111 "passage process"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A material processing that consists of first growing an organism in an environmental system and then removing the organism to be grown in another environmental system, a process which may be repeated with the objective of altering the organism or increasing its number."@en ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Serial_passage", "https://www.merriam-webster.com/dictionary/passage" ; a owl:Class ; rdfs:label "passage process"@en ; rdfs:subClassOf obo:OBI_0000094 . obo:OBI_0002748 obo:IAO_0000111 "passage history record"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item that is about the sequence of environmental systems in each of which is grown an organism in a passage process."@en ; obo:IAO_0000117 "John Judkins"@en ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Serial_passage"@en, "https://www.merriam-webster.com/dictionary/passage"@en ; a owl:Class ; rdfs:label "passage history record"@en ; rdfs:subClassOf obo:IAO_0000027, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0002747 ] . obo:OBI_0002750 obo:IAO_0000111 "Oxford Nanopore MinION" ; obo:IAO_0000112 "Approaches to Whole Mitochondrial Genome Sequencing on the Oxford Nanopore MinION" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A portable DNA sequencer which is manufactured by the Oxford Nanopore Technologies corporation, that uses consumable flow cells producing up to 30 Gb of DNA sequence data per flow cell. The sequencer produces real-time results and utilizes nanopore technology with up to 512 nanopore channels in the sensor array." ; obo:IAO_0000117 "PERSON: Bonita Lam" ; obo:IAO_0000118 "ONT MinION, MinION" ; obo:IAO_0000119 "https://nanoporetech.com/products/minion" ; a owl:Class ; rdfs:label "Oxford Nanopore MinION" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0002755 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002751 obo:IAO_0000111 "Oxford Nanopore GridION Mk1" ; obo:IAO_0000112 "Nineteen libraries were constructed and sequenced on nineteen different R9.4 FlowCells using the GridION X5 sequencer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencer that is manufactured by the Oxford Nanopore Technologies corporation, that can run and analyze up to five individual flow cells producing up to 150 Gb of data per run. The sequencer produces real-time results and utilizes nanopore technology with the option of running the flow cells concurrently or individually." ; obo:IAO_0000117 "PERSON: Bonita Lam" ; obo:IAO_0000118 "Oxford Nanopore GridION X5, GridION Mk1" ; obo:IAO_0000119 "https://nanoporetech.com/products/gridion" ; a owl:Class ; rdfs:label "Oxford Nanopore GridION Mk1" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0002755 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002752 obo:IAO_0000111 "Oxford Nanopore PromethION" ; obo:IAO_0000112 "Structural variants identified by Oxford Nanopore PromethION sequencing of the human genome." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencer that is manufactured by the Oxford Nanopore Technologies corporation, capable of running up to 48 flow cells and producing up to 7.6 Tb of data per run. The sequencer produces real-time results and utilizes Nanopore technology, with each flow cell allowing up to 3,000 nanopores to be sequencing simultaneously." ; obo:IAO_0000117 "PERSON: Bonita Lam" ; obo:IAO_0000118 "PromethION" ; obo:IAO_0000119 "https://nanoporetech.com/products/promethion" ; a owl:Class ; rdfs:label "Oxford Nanopore PromethION" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0002755 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002753 obo:IAO_0000111 "PRO-cap" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Precision nuclear run-on and sequencing to detect Pol II initiation sites" ; obo:IAO_0000117 "Bonita Lam" ; obo:IAO_0000118 "PRO-CAP" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1102" ; a owl:Class ; rdfs:label "PRO-cap" ; rdfs:subClassOf obo:OBI_0001177, obo:OBI_0002692, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000552 ] . obo:OBI_0002754 obo:IAO_0000111 ""@en, "cDNA library"@en ; obo:IAO_0000112 "cDNA library lacks the non-coding and regulatory elements found in genomic DNA"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A collection of DNA molecules with sequences complementary to a specified set of mRNA molecules and commonly developed by enzymatic reverse transcription."@en ; obo:IAO_0000117 "Dan Berrios"@en ; obo:IAO_0000119 "modified from Wikipedia"@en ; a owl:Class ; rdfs:label "cDNA library"@en ; rdfs:subClassOf obo:OBI_0000047 . obo:OBI_0002755 obo:IAO_0000111 "Oxford Nanopore Technologies" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organization that is developing and selling nanopore sequencing products and is based in the UK." ; obo:IAO_0000117 "James A. Overton" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Oxford_Nanopore_Technologies" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Oxford Nanopore Technologies" . obo:OBI_0002756 obo:IAO_0000111 "ordinal value specification"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical value specification in which the available categories were created with an explicit order." ; obo:IAO_0000116 """https://en.wikipedia.org/wiki/Ordinal_data provides references for follow-up, but more than one OBI developer has objected to \"...whose levels have natural, ordered categories and the distances between those categories is not known...\" Separate from that, an OBI mechanism for asserting the order of ordinal values specification levels with OWL has not been determined yet.""" ; obo:IAO_0000117 "Mark Andrew Miller, ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Bjoern Peters in https://github.com/obi-ontology/obi/issues/862" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/862" ; a owl:Class ; rdfs:label "ordinal value specification"@en ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0002759 obo:IAO_0000111 "ribosomal RNA-depleted RNA sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An RNA-seq assay in which highly abundant ribosomal RNAs are removed from total RNA before sequencing, resulting in more efficient transcript/gene detection." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "rRNA-deleted RNA sequencing assay" ; obo:IAO_0000119 "PMID:29556074" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "ribosomal RNA-depleted RNA sequencing assay" ; rdfs:subClassOf obo:OBI_0001271, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0002627 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001331 ] . obo:OBI_0002760 obo:IAO_0000111 "metatranscriptome sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An RNA-seq assay that determines the RNA sequence of microbial transcripts from a microbioal community of mixed species from a given microbiome." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "PMID:31450270" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "metatranscriptome sequencing assay" ; rdfs:subClassOf obo:OBI_0001271, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001331 ] . obo:OBI_0002761 obo:IAO_0000111 "lipid profiling assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay assay that detects and identifies lipids resulting from biochemical and cellular metabolism." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "lipidomic assay" ; obo:IAO_0000119 "OBI metabolite profiling assay" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "lipid profiling assay" ; rdfs:subClassOf obo:OBI_0000443 . obo:OBI_0002762 obo:IAO_0000111 "single-nucleus ATAC-seq" ; obo:IAO_0000112 "snATAC-seq can be used to dissect heterogeneity and delineate gene regulatory sequences in complex tissues, and uncover both the cell types and the regulatory elements in each cell type without prior knowledge." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An ATAC-seq assay in which single nuclei are isolated from frozen tissue samples, through a protocol designed to maximally preserve nucleus integrity during sample processing and optimize transposase-mediated fragmentation of chromatin in individual nuclei." ; obo:IAO_0000117 "Mark Andrew Miller, ORCID:0000-0001-9076-6066" ; obo:IAO_0000118 "snATAC-seq" ; obo:IAO_0000119 "http://www.biorxiv.org/content/early/2017/07/06/159137" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/864" ; obo:IAO_0000234 "ENCODE" ; a owl:Class ; rdfs:label "single-nucleus ATAC-seq" ; rdfs:subClassOf obo:OBI_0002039 . obo:OBI_0002763 obo:IAO_0000111 "16s ribosomal gene sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An amplicon sequencing assay in which the amplicon is derived from universal primers used to amplify the 16S ribosomal RNA gene from isolate bacterial genomic DNA or metagenomic DNA from a microbioal community. Resulting sequences are compared to reference 16S sequence databases to identify or classify bacteria present within a given sample." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "16S rRNA sequencing assay" ; obo:IAO_0000119 "PMID:31450270" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "16s ribosomal gene sequencing assay" ; rdfs:subClassOf obo:OBI_0001960, obo:OBI_0002767, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0000181 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001969 ] . obo:OBI_0002764 obo:IAO_0000111 "single-cell ATAC-seq" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An ATAC assay designed to robustly map the accessible genome of individual cells, using sequencing integrated into a programmable microfluidics platform, in order to provide insights into cell-to-cell variation in accessibility profiles." ; obo:IAO_0000117 "Mark Andrew Miller, ORCID:0000-0001-9076-6066" ; obo:IAO_0000118 "scATAC-seq" ; obo:IAO_0000119 "http://www.nature.com/nature/journal/v523/n7561/full/nature14590.html" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/864" ; obo:IAO_0000234 "ENCODE" ; a owl:Class ; rdfs:label "single-cell ATAC-seq" ; rdfs:subClassOf obo:OBI_0002039 . obo:OBI_0002765 obo:IAO_0000111 "microbiome protein expression profiling assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A protein expression profiling assay of microbial proteins extracted from a microbioal community of mixed species from a given microbiome." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "metaproteomic assay" ; obo:IAO_0000119 "PMID:31450270" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "microbiome protein expression profiling assay" ; rdfs:subClassOf obo:OBI_0000615, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000000001 ] ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0002766 obo:IAO_0000111 "cytokine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay to study presence, concentration, or amount of cytokines." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "PMID:23603216" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "cytokine assay" ; rdfs:subClassOf obo:OBI_0000443 . obo:OBI_0002767 obo:IAO_0000111 "amplicon sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A sequencing assay in which a DNA or RNA input molecule is amplified by PCR and the product sequenced." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "PMID:29628929", "PMID:31450270" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "amplicon sequencing assay" ; rdfs:subClassOf obo:OBI_0600047, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0001108 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001108 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001010 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001010 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0002768 obo:IAO_0000111 "whole virome sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A whole metagenome sequencing assay that intends to provide information on multiple genome sequences from different viruses present in the same input sample." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "OBI:0002623" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "whole virome sequencing assay" ; rdfs:subClassOf obo:OBI_0002623 . obo:OBI_0002769 obo:IAO_0000111 "karyotype information"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A genetic characteristics information that is about the number and appearance of chromosomes in the nucleus of an eukaryotic cell."@en ; obo:IAO_0000117 "Jie Zheng"@en ; obo:IAO_0000119 "EFO_0004426 karyotype"@en ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1097"@en ; obo:IAO_0000234 "VEuPathDB"@en ; a owl:Class ; rdfs:label "karyotype information"@en ; rdfs:subClassOf obo:OBI_0001404 . obo:OBI_0002770 obo:IAO_0000111 "partial karyotype information"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A karyotype information that is about the structural variation of partial genome rather than whole genome."@en ; obo:IAO_0000117 "Jie Zheng"@en ; obo:IAO_0000119 "VEuPathDB"@en ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1097"@en ; obo:IAO_0000234 "VEuPathDB"@en ; a owl:Class ; rdfs:label "partial karyotype information"@en ; rdfs:subClassOf obo:OBI_0002769, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0002771 ] . obo:OBI_0002771 obo:IAO_0000111 "full karyotype information"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A karyotype information that is about the structural variation of the whole genome."@en ; obo:IAO_0000117 "Jie Zheng"@en ; obo:IAO_0000119 "OBI group"@en ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1097"@en ; a owl:Class ; rdfs:label "full karyotype information"@en ; rdfs:subClassOf obo:OBI_0002769 . obo:OBI_0002772 obo:IAO_0000111 "presence or over-threshold value specification"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 """An ordinal value specification that indicates that either a) an analyte or mesaurand is present in an evaluant, or b) that the amount of analyte/measurand detected is over some predetermined threshold.""" ; obo:IAO_0000117 "Mark Andrew Miller, ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "LOINC User's Guide, Version 2.68, PUBLISHED JUNE 2020, page 32" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1202" ; a owl:Class ; rdfs:comment "bump" ; rdfs:label "presence or over-threshold value specification"@en ; rdfs:subClassOf obo:OBI_0002756 . obo:OBI_0002773 obo:IAO_0000111 "single-value binding of antibody with reporter to antigen assay" ; obo:IAO_0000112 "Detection of SARS-CoV-2 IgG antibodies by an immunoassay method, such as enzyme-linked immunosorbent assay. This test is used in conjunction with SARS-CoV-2 IgA and IgM to aid in the diagnosis of COVID-19 and in the identification of individuals infected with SARS-CoV-2." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that detects the linking of antigens and antibodies via special signaling mechanisms, such as EIA, ELISA, chemiluminescence, etc. that produces one measure (quantitative or qualitative) of the analyte of interest" ; obo:IAO_0000116 "LOINC indicates that this class would not include flow cytometry or any technique that can determine the localization of an analyte, such as peroxidase immune staining or indirect immunofluorescence (IFA)" ; obo:IAO_0000117 "Mark Andrew Miller, ORCID:0000-0001-9076-6066" ; obo:IAO_0000118 "IA", "immunoassay" ; obo:IAO_0000119 "LOINC User's Guide, Version 2.68, PUBLISHED JUNE 2020, page 47" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1203" ; a owl:Class ; rdfs:label "single-value binding of antibody with reporter to antigen assay" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0002774 obo:IAO_0000111 "platelet-poor plasma specimen"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A blood plasma specimen that is the output of some platelet-poor plasma preparation and is the portion of plasma that contains fewer than 10,000 platelets per microliter."@en ; obo:IAO_0000117 "PERSON: Matthew Diller"@en ; a owl:Class ; rdfs:label "platelet-poor plasma specimen"@en ; rdfs:subClassOf obo:OBI_0100016 . obo:OBI_0002775 obo:IAO_0000111 "platelet-poor plasma preparation process"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A material component separation process in which (1) whole blood is first centrifuged to separate red blood cells from blood plasma, which forms the supernatant, and (2) the blood plasma is then centrifuged to separate platelets from the plasm."@en ; obo:IAO_0000117 "PERSON: Matthew Diller"@en ; a owl:Class ; rdfs:label "platelet-poor plasma preparation process"@en ; rdfs:subClassOf obo:OBI_0600014 . obo:OBI_0002776 obo:IAO_0000111 "cytometry analysis by automated gating" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A gating in which the output of a flow- or mass- cytometry experiment is separated into gates that were set by an algorithm in order to quantify the frequency of different cell populations of interest." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "CMI-PB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1226" ; a owl:Class ; rdfs:label "cytometry analysis by automated gating" ; rdfs:subClassOf obo:OBI_0200077 . obo:OBI_0002777 obo:IAO_0000111 "cytometry analysis by manual gating" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A gating in which the output of a flow- or mass- cytometry experiment is separated into gates that were set by a human operator in order to quantify the frequency of different cell populations of interest." ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000119 "CMI-PB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1226" ; a owl:Class ; rdfs:label "cytometry analysis by manual gating" ; rdfs:subClassOf obo:OBI_0200077 . obo:OBI_0002778 obo:IAO_0000111 "tracheal aspirate specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is collected with a suctioning tube from the trachea." ; obo:IAO_0000117 "Asiyah Yu Lin ORCID:0000-0003-2620-0345" ; obo:IAO_0000118 "tracheal wash specimen" ; obo:IAO_0000119 "PMID:25338241" ; a owl:Class ; rdfs:label "tracheal aspirate specimen" ; rdfs:subClassOf obo:OBI_0100051, [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002785 ] ) ], [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] ] ) ] . obo:OBI_0002779 obo:IAO_0000111 "mid-turbinate nasal swab specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is collected with a mid-turbinate nasal swab from the turbinate area of the nasal cavity." ; obo:IAO_0000117 "Asiyah Yu Lin ORCID:0000-0003-2620-0345" ; obo:IAO_0000119 "https://seattlechildrenslab.testcatalog.org/catalogs/185/files/11633" ; a owl:Class ; rdfs:label "mid-turbinate nasal swab specimen" ; rdfs:subClassOf obo:OBI_0002599 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0005921 ] ) ] ] ) ] ) ] . obo:OBI_0002780 obo:IAO_0000111 "nasal aspirate specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is collected with a suctioning tube from the nasal cavity." ; obo:IAO_0000117 "Asiyah Yu Lin ORCID:0000-0003-2620-0345" ; obo:IAO_0000118 "nasal wash specimen|nasopharyngeal aspirate" ; obo:IAO_0000119 "Asiyah Yu Lin ORCID:0000-0003-2620-0345" ; a owl:Class ; rdfs:label "nasal aspirate specimen" ; rdfs:subClassOf obo:OBI_0100051 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002785 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0001826 ] ) ] ] ) ] ) ] . obo:OBI_0002781 obo:IAO_0000111 "lower respiratory tract aspirate specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is collected with a suctioning tube from the lower respiratory tract." ; obo:IAO_0000117 "Asiyah Yu Lin ORCID:0000-0003-2620-0345" ; obo:IAO_0000118 "lower respiratory tract wash specimen" ; obo:IAO_0000119 "Asiyah Yu Lin ORCID:0000-0003-2620-0345" ; a owl:Class ; rdfs:label "lower respiratory tract aspirate specimen" ; rdfs:subClassOf obo:OBI_0002783 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002785 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0001558 ] ) ] ] ) ] ) ] . obo:OBI_0002782 obo:IAO_0000111 "upper respiratory specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from the upper respiratory tract" ; obo:IAO_0000117 "Asiyah Yu Lin ORCID:0000-0003-2620-0345" ; obo:IAO_0000119 "Asiyah Yu Lin ORCID:0000-0003-2620-0345" ; a owl:Class ; rdfs:label "upper respiratory specimen" ; rdfs:subClassOf obo:OBI_0002599 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0001557 ] ) ] ] ) ] ) ] . obo:OBI_0002783 obo:IAO_0000111 "lower respiratory tract specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from the lower respiratory tract." ; obo:IAO_0000117 "Asiyah Yu Lin ORCID:0000-0003-2620-0345" ; obo:IAO_0000119 "Asiyah Yu Lin ORCID:0000-0003-2620-0345" ; a owl:Class ; rdfs:label "lower respiratory tract specimen" ; rdfs:subClassOf obo:OBI_0100051 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0001558 ] ) ] ] ) ] . obo:OBI_0002784 obo:IAO_0000111 "anterior nasal swab specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from the anterior nasal wall" ; obo:IAO_0000117 "Asiyah Yu Lin ORCID:0000-0003-2620-0345" ; obo:IAO_0000119 "Asiyah Yu Lin ORCID:0000-0003-2620-0345" ; a owl:Class ; rdfs:label "anterior nasal swab specimen" ; rdfs:subClassOf obo:OBI_0002599 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_3000016 ] ) ] ] ) ] ) ] . obo:OBI_0002785 obo:IAO_0000111 "aspiration specimen collection"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Procedure using suction, usually with a thin needle and syringe, to remove bodily fluid or tissue." ; obo:IAO_0000117 "Asiyah Yu Lin|ORCID:0000-0003-2620-0345" ; obo:IAO_0000118 "aspiration procedure" ; obo:IAO_0000119 "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C15631"^^xsd:anyURI ; a owl:Class ; rdfs:label "aspiration specimen collection"@en ; rdfs:subClassOf obo:OBI_0000659 . obo:OBI_0002786 obo:IAO_0000111 "personal protective device" ; obo:IAO_0000112 "Examples of PPE include respirators, gloves, aprons, fall protection, and full body suits, as well as head, eye and foot protection.", "PPE is equipment worn by a worker to minimize exposure to specific hazards." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A device which is a wearable garment designed to protect the wearer's body from injury or infection." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000118 "PPE", "personal protective equipment" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Personal_protective_equipment" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "personal protective device" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0002787 obo:IAO_0000111 "face mask" ; obo:IAO_0000112 "A systematic review on the efficacy of face coverings against respiratory viruses analyzed 19 randomized trials and concluded that use of face masks and respirators appeared to be protective in both health care and community settings" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A personal protective device worn over the nose and mouth as a respiratory filter to inhibit the flow of particles." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000118 "face covering", "respirator" ; obo:IAO_0000119 "Adapted from https://dictionary.cambridge.org/dictionary/english/face-mask" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "face mask" ; rdfs:subClassOf obo:OBI_0002786 . obo:OBI_0002788 obo:IAO_0000111 "non-medical mask" ; obo:IAO_0000112 "A non-medical mask may contain fabrics that are not regulated for use in surgical masks or respirators, or may not be designed to form a seal around the nose and mouth." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A face mask not manufactured according to medical equipment standards." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000118 "cloth mask" ; obo:IAO_0000119 "https://www.canada.ca/en/public-health/services/diseases/2019-novel-coronavirus-infection/prevention-risks/about-non-medical-masks-face-coverings.html" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "non-medical mask" ; rdfs:subClassOf obo:OBI_0002787 . obo:OBI_0002789 obo:IAO_0000111 "medical mask" ; obo:IAO_0000112 "The finding of a much higher rate of infection in the cloth mask arm could be interpreted as harm caused by cloth masks, efficacy of medical masks, or most likely a combination of both." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A face mask manufactured according to a recognized medical equipment standard." ; obo:IAO_0000117 "https://orcid.org/0000-0002-9578-0788" ; obo:IAO_0000118 "surgical mask" ; obo:IAO_0000119 "https://www.canada.ca/en/public-health/services/diseases/2019-novel-coronavirus-infection/prevention-risks/about-non-medical-masks-face-coverings.html" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "medical mask" ; rdfs:subClassOf obo:OBI_0002787 . obo:OBI_0002790 obo:IAO_0000111 "N95 respirator" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A face mask that meets the U.S. National Institute for Occupational Safety and Health (NIOSH) N95 classification of air filtration, meaning that it filters at least 95% of incoming airborne particles." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000118 "N95", "N95 face mask", "N95 facemask", "N95 respirator mask" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/N95_mask" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "N95 respirator" ; rdfs:subClassOf obo:OBI_0002787 . obo:OBI_0002791 obo:IAO_0000111 "face shield" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A personal protective device used to protect the wearer's entire face (or part of it) from hazards such as flying objects and road debris, chemical splashes, or alternately potentially infectious materials." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000118 "faceshield", "splash shield" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Face_shield" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "face shield" ; rdfs:subClassOf obo:OBI_0002786 . obo:OBI_0002792 obo:IAO_0000111 "patient gown" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A personal protective clothing item which is a gown designed for use by a patient to facilitate caregiving by medical staff." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000118 "hospital gown" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Patient_gown" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "patient gown" ; rdfs:subClassOf obo:OBI_0002800 . obo:OBI_0002793 obo:IAO_0000111 "scrubs" ; obo:IAO_0000112 "Examples consist of a short-sleeve V-necked shirt and drawstring pants or a short-sleeve calf-length dress, a tie-back or bouffant-style cap, a mask, a surgical gown, latex gloves, and supportive closed-toe shoes." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A personal protective clothing item which is sterilized and which is worn by a health care professional. It can reference a shirt and pants or dress, and depending on medical protocol, may include a medical cap." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000118 "scrub clothing item" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Scrubs_(clothing)" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "scrubs" ; rdfs:subClassOf obo:OBI_0002800 . obo:OBI_0002794 obo:IAO_0000111 "reusable patient gown" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A patient gown intended to be reused after being laundered." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Patient_gown" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "reusable patient gown" ; rdfs:subClassOf obo:OBI_0002792 . obo:OBI_0002795 obo:IAO_0000111 "disposable patient gown" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A patient gown intended for a single period of continuous use and then disposed of." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Patient_gown" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "disposable patient gown" ; rdfs:subClassOf obo:OBI_0002792 . obo:OBI_0002796 obo:IAO_0000111 "medical gown" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A personal protective clothing item which is a gown worn by a medical professional in order to provide a barrier between patient and professional." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000118 "hospital gown" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Medical_gown" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "medical gown" ; rdfs:subClassOf obo:OBI_0002800 . obo:OBI_0002797 obo:IAO_0000111 "apron" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A garment which is worn over other clothing and covers mainly the front of the body." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Apron" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "apron" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0002798 obo:IAO_0000111 "surgical gown" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A medical gown which is subjected to a sterilization process and which is intended to be worn by a medical professional during surgical procedures." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "surgical gown" ; rdfs:subClassOf obo:OBI_0002796 . obo:OBI_0002799 obo:IAO_0000111 "personal protective glove" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A personal protective device which is a glove." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "personal protective glove" ; rdfs:subClassOf obo:OBI_0002800 . obo:OBI_0002800 obo:IAO_0000111 "personal protective clothing item" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A personal protective device which consists of a garment that serves in place of or in addition to regular body clothing." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "personal protective clothing item" ; rdfs:subClassOf obo:OBI_0002786 . obo:OBI_0002802 obo:IAO_0000111 "laboratory coat" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A personal protective clothing item which is an overcoat worn by medical or laboratory professionals." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000118 "white coat" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/White_coat" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "laboratory coat" ; rdfs:subClassOf obo:OBI_0002800 . obo:OBI_0002803 obo:IAO_0000111 "medical glove" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A personal protective glove which is disposable and is used during medical examinations and procedures to help prevent cross-contamination between caregivers and patients." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Medical_glove" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "medical glove" ; rdfs:subClassOf obo:OBI_0002799 . obo:OBI_0002804 obo:IAO_0000111 "nitrile glove" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A personal protective glove which is made out of nitrile rubber." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Medical_glove" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "nitrile glove" ; rdfs:subClassOf obo:OBI_0002799 . obo:OBI_0002805 obo:IAO_0000111 "transparent partition" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A device which is a transparent constructed barrier, usually made out of acrylic (Plexiglass) or polycarbonate plastic, installed in facilities to intercept respiratory droplets, encourage physical distancing requirements." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000118 "transparent partition" ; obo:IAO_0000119 "https://ncceh.ca/content/blog/physical-barriers-covid-19-infection-prevention-and-control-commercial-settings" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "transparent droplet barrier" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0002806 obo:IAO_0000111 "footwear cover" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A personal protective device which is an impermiable material which covers a shoe or boot in order to prevent spread of specific environmental contaminants." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000118 "boot cover", "shoe cover" ; obo:IAO_0000119 "https://en.wiktionary.org/wiki/shoecover" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "footwear cover" ; rdfs:subClassOf obo:OBI_0002800 . obo:OBI_0002807 obo:IAO_0000111 "disposable footwear cover" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A footwear cover which is designed for a single period of continuous use and then disposed of." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "disposable footwear cover" ; rdfs:subClassOf obo:OBI_0002806 . obo:OBI_0002808 obo:IAO_0000111 "reusable footwear cover" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A footwear cover which is designed for repeated use." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "reusable footwear cover" ; rdfs:subClassOf obo:OBI_0002806 . obo:OBI_0002809 obo:IAO_0000111 "surgical N95 respirator" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A N95 respirator which has been approved by the FDA as a surgical mask." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000118 "healthcare respirator", "medical respirator", "surgical N95", "surgical N95 respirator" ; obo:IAO_0000119 "https://multimedia.3m.com/mws/media/1794572O/surgical-n95-vs-standard-n95-which-to-consider.pdf" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "surgical N95 respirator" ; rdfs:subClassOf obo:OBI_0002790 . obo:OBI_0002810 obo:IAO_0000111 "protective coverall" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A personal protective clothing item which is a loose fitting coverall for ease of movement, with sleeves, full leggings and often a hood to cover the head. These can also include overshoe pieces to cover footwear and protect against contamination." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "https://www.safeopedia.com/definition/863/disposable-coveralls" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "protective coverall" ; rdfs:subClassOf obo:OBI_0002800 . obo:OBI_0002811 obo:IAO_0000111 "protective sleeve" ; obo:IAO_0000112 "A protective sleeve can be designed to provide protection from heat, welding spatter or hot metal, chemicals, sharp objects, paint or other liquids." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A personal protective clothing item which is a protective cover worn over the arm." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "https://www.safeopedia.com/definition/974/protective-sleeves" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "protective sleeve" ; rdfs:subClassOf obo:OBI_0002800 . obo:OBI_0002812 obo:IAO_0000111 "protective apron" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A personal protective clothing item which is an apron." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Apron" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "protective apron" ; rdfs:subClassOf obo:OBI_0002800 . obo:OBI_0002813 obo:IAO_0000111 "medical cap" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A personal protective device which is worn on the head that helps prevent transmission of contaminants contained in hair and scalp." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000118 "bouffant cap", "bouffant hat", "medical bonnet", "scrub cap", "surgical hat" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Scrubs_(clothing)" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1193" ; a owl:Class ; rdfs:label "medical cap" ; rdfs:subClassOf obo:OBI_0002800 . obo:OBI_0002814 obo:IAO_0000111 "specimen collection device" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A device used to collect a specimen." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; a owl:Class ; rdfs:label "specimen collection device" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0002815 obo:IAO_0000111 "has representation"@en ; obo:IAO_0000112 "12th arrondissement of Paris"@en, "20g", "I feel sick to my stomach every Tuesday"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "'has representation' is a data property that attaches between an information content entity and a value that contains linguistically or computationally coded text."@en ; obo:IAO_0000116 "Further processing may enable the value to be represented in a component data structure such as an OBI value specification."@en ; obo:IAO_0000117 "Damion Dooley", "Mark Miller" ; dc:date "2019-07-14T07:05:50Z"^^xsd:dateTime ; a owl:DatatypeProperty ; rdfs:label "has representation"@en . obo:OBI_0002816 obo:IAO_0000111 "chromatography vial" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A vial with cap and container material suited to optical, sanitary and handling requirements of chromatography." ; obo:IAO_0000117 "PERSON:Daniel Schober" ; obo:IAO_0000119 "GROUP:", "http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01117" ; a owl:Class ; rdfs:label "chromatography vial" ; rdfs:subClassOf obo:OBI_0000601 . obo:OBI_0002819 obo:IAO_0000111 "specimen pad" ; obo:IAO_0000112 "An absorbent pad and its accompanying container are designed to provide safe storage and transport to various degrees for diagnostic and clinical samples, infectious and hazardous materials, chemicals, pharmaceuticals and environmental samples." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A sample collection device consisting of a soft flexible, absorbent pad usually made from natural material such as gauze or cotton, used to absorb specimen fluid or particulate matter." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000118 "absorbant pad", "polysponge", "sample pad", "sampling sponge", "specimen sponge", "surface wipe", "swab" ; obo:IAO_0000119 "Derived from NCIT sponge definition." ; a owl:Class ; rdfs:label "specimen pad" ; rdfs:subClassOf obo:OBI_0002814 . obo:OBI_0002820 obo:IAO_0000111 "specimen collection swab stick" ; obo:IAO_0000112 "A swab stick allows a worker to collect samples without touching the inside of the bag" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen collection device which is a specimen pad attached to a long handle used to collect specimen material." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000118 "polyprobe", "sponge probe", "sponge stick", "sponge-stick" ; obo:IAO_0000119 "https://medical-dictionary.thefreedictionary.com/swab" ; a owl:Class ; rdfs:label "specimen collection swab stick" ; rdfs:subClassOf obo:OBI_0002814 . obo:OBI_0002821 obo:IAO_0000111 "cotton swab" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A device which is a cotton pad mounted on one or both ends of a stick." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000118 "Q-tip", "swab-sampler" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Cotton_swab" ; a owl:Class ; rdfs:label "cotton swab" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0002822 obo:IAO_0000111 "drag swab" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen collection device consisting of a specimen pad made of sterile gauze which is aseptically attached to a pole by clips or to a string" ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "https://www.fda.gov/food/laboratory-methods-food/environmental-sampling-and-detection-salmonella-poultry-houses" ; a owl:Class ; rdfs:label "drag swab" ; rdfs:subClassOf obo:OBI_0002814, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0002819 ] . obo:OBI_0002823 obo:IAO_0000111 "pre-moistened swab stick" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A specimen collection swab stick that is pre-moistened with liquid prior to sampling." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; a owl:Class ; rdfs:label "pre-moistened swab stick" ; rdfs:subClassOf obo:OBI_0002820 . obo:OBI_0002824 obo:IAO_0000111 "surface wipe" ; obo:IAO_0000112 "Surface sampling procedures involved the use of polyester wipes, swabs, contact slides (two types), and adhesive tapes; a gelatin filter was used to sample the air." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A sample collection device consisting of a thin, less absorbent sheet, used to collect material from surfaces." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "https://www.science.gov/topicpages/s/surface+wipe+sampling.html" ; a owl:Class ; rdfs:label "surface wipe" ; rdfs:subClassOf obo:OBI_0002814 . obo:OBI_0002830 obo:IAO_0000111 "catheter" ; obo:IAO_0000112 "A catheter left inside the body, either temporarily or permanently, may be referred to as an indwelling catheter." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A device which is a flexible tube inserted into a body and which enables transfer of fluids into or out of a body." ; obo:IAO_0000117 "https://orcid.org/0000-0002-8844-9165" ; obo:IAO_0000119 "http://purl.bioontology.org/ontology/MESH/D057785" ; a owl:Class ; rdfs:label "catheter" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0002897 obo:IAO_0000111 "surveillance process" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An investigation in which some entity is monitored, and data concerning that entity collected, interpreted, and disseminated, for the purpose of managing, directing, or protecting that entity, or some other entity." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Shane Babcock, OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1181" ; obo:IAO_0000234 "IDO, VEuPathDB" ; a owl:Class ; rdfs:label "surveillance process" ; rdfs:subClassOf obo:OBI_0000066 . obo:OBI_0002898 obo:IAO_0000111 "cluster study group role" ; obo:IAO_0000112 "A cluster study group consisting of eight pregnant women who lived close enough to each other so that a community promoter could readily walk to each compound." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study group role that is the result of the allocation of a cluster of study-defined groupings of people in a clinical trial to receive a specific intervention/treatment, or no intervention, according to the trial's protocol." ; obo:IAO_0000117 "Chris Stoeckert, Brianna Lindsay" ; obo:IAO_0000118 "cluster study arm" ; obo:IAO_0000119 "ClinEpiDB" ; a owl:Class ; rdfs:label "cluster study group role" ; rdfs:subClassOf obo:OBI_0000174 . obo:OBI_0002899 obo:IAO_0000111 "compound study group role" ; obo:IAO_0000112 "A compound study group consisting of geographically proximate households that share a common water source." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study group role that is the result of the allocation of a compound of geographically-proximate households with a shared component in a clinical trial to receive a specific intervention/treatment, or no intervention, according to the trial's protocol." ; obo:IAO_0000117 "Chris Stoeckert, Brianna Lindsay" ; obo:IAO_0000118 "compound study arm" ; obo:IAO_0000119 "ClinEpiDB" ; a owl:Class ; rdfs:label "compound study group role" ; rdfs:subClassOf obo:OBI_0000174 . obo:OBI_0002900 obo:IAO_0000111 "ultraviolet light source" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A light source that provides ultraviolet (UV) light for use in a distant area using a delivery system." ; obo:IAO_0000117 "Person: Jie Zheng" ; obo:IAO_0000118 "UV light source" ; obo:IAO_0000119 "Person: Jie Zheng" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1200" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "ultraviolet light source" ; rdfs:subClassOf obo:OBI_0400065 . obo:OBI_0002901 obo:IAO_0000111 "visible light source" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A light source that provides visible light for use in a distant area using a delivery system." ; obo:IAO_0000117 "Person: Jie Zheng" ; obo:IAO_0000119 "Person: Jie Zheng" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1200" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "visible light source" ; rdfs:subClassOf obo:OBI_0400065 . obo:OBI_0002902 obo:IAO_0000111 "solar light source" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A light source that light is produced from solar energy." ; obo:IAO_0000117 "Person: Chris Stoeckert", "Person: Jie Zheng" ; obo:IAO_0000119 "Person: Chris Stoeckert", "Person: Jie Zheng" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1200" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "solar light source" ; rdfs:subClassOf obo:OBI_0400065 . obo:OBI_0002903 obo:IAO_0000111 "BioGents" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organization that manufactures mosquito traps and other mosquito control products." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "WEB:https://eu.biogents.com/about-biogents/" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "BioGents" . obo:OBI_0002904 obo:IAO_0000111 "adult arthropod specimen collection process" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A live arthropod specimen collection process in which the arthropods are in the adult stage." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "collection of adults" ; obo:IAO_0000119 "MIRO:30000052" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "adult arthropod specimen collection process" ; rdfs:subClassOf obo:OBI_0002919 . obo:OBI_0002905 obo:IAO_0000111 "animal-biting arthropod specimen collection by aspiration" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod specimen collection by aspiration that occurs while the arthropod is biting an animal." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "animal biting catch" ; obo:IAO_0000119 "MIRO:30000012" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "animal-biting arthropod specimen collection by aspiration" ; rdfs:subClassOf obo:OBI_0002912 . obo:OBI_0002906 obo:IAO_0000111 "animal-biting outdoor arthropod specimen collection by aspiration" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An animal-biting arthropod specimen collection by aspiration that occurs outside a building." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "animal biting catch - outdoors" ; obo:IAO_0000119 "MIRO:30000014" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "animal-biting outdoor arthropod specimen collection by aspiration" ; rdfs:subClassOf obo:OBI_0002905 . obo:OBI_0002907 obo:IAO_0000111 "aquatic arthropod specimen collection process" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod specimen collection process that has the objective of collecting mosquitoes from an aquatic environment." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "aquatic environment catch" ; obo:IAO_0000119 "MIRO:30000048" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "aquatic arthropod specimen collection process" ; rdfs:subClassOf obo:OBI_0002913 . obo:OBI_0002908 obo:IAO_0000111 "arthropod resting in animal house specimen collection by aspiration" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod specimen collection by aspiration that catches specimens resting inside an animal house." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "animal shed resting catch" ; obo:IAO_0000119 "MIRO:30000027" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "arthropod resting in animal house specimen collection by aspiration" ; rdfs:subClassOf obo:OBI_0002912 . obo:OBI_0002909 obo:IAO_0000111 "arthropod resting outdoors on artificial support specimen collection by aspiration" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod resting outdoors specimen collection by aspiration that occurs while the arthropod rests on a processed material such as a wall or furniture." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "outdoors shelter catch - artificial" ; obo:IAO_0000119 "MIRO:30000026" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "arthropod resting outdoors on artificial support specimen collection by aspiration" ; rdfs:subClassOf obo:OBI_0002911 . obo:OBI_0002910 obo:IAO_0000111 "arthropod resting outdoors on natural support specimen collection by aspiration" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod resting outdoors specimen collection by aspiration that occurs while the arthropod rests on an unprocessed material such as a plant." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "outdoors shelter catch - natural" ; obo:IAO_0000119 "MIRO:30000025" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "arthropod resting outdoors on natural support specimen collection by aspiration" ; rdfs:subClassOf obo:OBI_0002911 . obo:OBI_0002911 obo:IAO_0000111 "arthropod resting outdoors specimen collection by aspiration" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An animal-biting arthropod specimen collection by aspiration that occurs while the arthropod is resting outside a building during a period of inactivity." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "outdoors shelter catch" ; obo:IAO_0000119 "MIRO:30000024" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "arthropod resting outdoors specimen collection by aspiration" ; rdfs:subClassOf obo:OBI_0002905 . obo:OBI_0002912 obo:IAO_0000111 "arthropod specimen collection by aspiration" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A live arthropod specimen collection process that involves the use of an aspirator, a device which draws an arthropod by suction into a container." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "catch by aspiration" ; obo:IAO_0000119 "MIRO:30000043" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "arthropod specimen collection by aspiration" ; rdfs:subClassOf obo:OBI_0002904 . obo:OBI_0002913 obo:IAO_0000111 "arthropod specimen collection process" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen collection process that has the objective of collecting arthropods as specimens." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "collection of arthropods", "field population catch" ; obo:IAO_0000119 "MIRO:30000044" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "arthropod specimen collection process" ; rdfs:subClassOf obo:OBI_0000659 . obo:OBI_0002914 obo:IAO_0000111 "human-biting arthropod specimen collection by aspiration" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod specimen collection by aspiration that occurs while the arthropod is biting a human." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "man biting catch" ; obo:IAO_0000119 "MIRO:30000017" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "human-biting arthropod specimen collection by aspiration" ; rdfs:subClassOf obo:OBI_0002912 . obo:OBI_0002915 obo:IAO_0000111 "human-biting indoor arthropod specimen collection by aspiration" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod specimen collection by aspiration that occurs while the arthropod is biting a human inside a building." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "man biting catch - indoors" ; obo:IAO_0000119 "MIRO:30000019" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "human-biting indoor arthropod specimen collection by aspiration" ; rdfs:subClassOf obo:OBI_0002914 . obo:OBI_0002916 obo:IAO_0000111 "human-biting outdoor arthropod specimen collection by aspiration" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod specimen collection by aspiration designed to catch specimens that are in the process of biting a human outside a building." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "man biting catch - outdoors" ; obo:IAO_0000119 "MIRO:30000018" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "human-biting outdoor arthropod specimen collection by aspiration" ; rdfs:subClassOf obo:OBI_0002914 . obo:OBI_0002917 obo:IAO_0000111 "knockdown arthropod specimen collection by pyrethrum spray" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A knockdown arthropod specimen collection process in which the pesticide is pyrethrum." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "pyrethrum spray catch" ; obo:IAO_0000119 "MIRO:30000023" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "knockdown arthropod specimen collection by pyrethrum spray" ; rdfs:subClassOf obo:OBI_0002918 . obo:OBI_0002918 obo:IAO_0000111 "knockdown arthropod specimen collection process" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod specimen collection process that involves exposing arthropods to pesticide, then collecting them once they become dead or immobilized." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "knockdown collection" ; obo:IAO_0000119 "IRO:0000014" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "knockdown arthropod specimen collection process" ; rdfs:subClassOf obo:OBI_0002919 . obo:OBI_0002919 obo:IAO_0000111 "live arthropod specimen collection process" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod specimen collection process meant to collect live specimens." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "catch of live specimens" ; obo:IAO_0000119 "MIRO:30000044", "VSMO:0001445" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "live arthropod specimen collection process" ; rdfs:subClassOf obo:OBI_0002913 . obo:OBI_0002920 obo:IAO_0000111 "arthropod trap" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device designed to catch arthropods." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "MIRO:30000011" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "arthropod trap" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0002921 obo:IAO_0000111 "artificial pit shelter" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod trap, consisting of a pit dug in the ground to provide a space for arthropods to rest and be collected." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "IRO:0000005" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "artificial pit shelter" ; rdfs:subClassOf obo:OBI_0002939 . obo:OBI_0002922 obo:IAO_0000111 "baited net trap" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An arthropod trap designed to work with an animal (which could be human) inside a netted structure. This structure is designed so that an arthropod, attracted by the animal, can fly into the netted structure but can neither escape nor reach the animal." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "baited net trap" ; rdfs:subClassOf obo:OBI_0002920 . obo:OBI_0002923 obo:IAO_0000111 "barrier trap" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod trap consisting of a static physical barrier designed to funnel arthropods in flight into a container." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "IRO:0000017" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "barrier trap" ; rdfs:subClassOf obo:OBI_0002920 . obo:OBI_0002924 obo:IAO_0000111 "BG-Counter" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device manufactured by BioGents that is designed to count mosquitoes passing through the device, differentiating the mosquitoes from other arthropods." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "IRO:0000143" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "BG-Counter" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:hasValue obo:OBI_0002903 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002925 obo:IAO_0000111 "BG-Sentinel trap" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod trap that is manufactured by Biogents and is designed to attract arthropods through the use of a motorized fan to mimic convection currents produced by a human. The current also pulls arthropods into the trap, where a layer of gauze prevents the arthropods from escaping along with the air current." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "IRO:0000028", "VSMO:0001906" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "BG-Sentinel trap" ; rdfs:subClassOf obo:OBI_0002920, [ a owl:Restriction ; owl:hasValue obo:OBI_0002903 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0002926 obo:IAO_0000111 "Centers for Disease Control and Prevention light trap" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A light trap that is designed similarly to the New Jersey trap—in that it uses motorized suction and light attractant—and is powered by a six-volt battery." ; obo:IAO_0000116 "This trap is also designed to be lightweight and operate in environments in which electricity may be scarce." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "CDC light trap" ; obo:IAO_0000119 "IRO:0000163" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "Centers for Disease Control and Prevention light trap" ; rdfs:subClassOf obo:OBI_0002930 . obo:OBI_0002927 obo:IAO_0000111 "dipper for arthropod immatures" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is designed for the collection of arthropod larvae or pupae from water and has the shape of a ladle or a pan." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "dipper for immatures" ; obo:IAO_0000119 "VSMO:0001479" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "dipper for arthropod immatures" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0002928 obo:IAO_0000111 "encephalitis virus surveillance trap" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A light trap that uses carbon dioxide as attractant. The trap consists of a container of dry ice with holes in the bottom to allow the carbon dioxide to flow downward into a separate container, in which a motorized fan creates suction to collect arthropods." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "EVS trap" ; obo:IAO_0000119 "IRO:0000029", "VSMO:0001295" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "encephalitis virus surveillance trap" ; rdfs:subClassOf obo:OBI_0002930 . obo:OBI_0002929 obo:IAO_0000111 "gravid trap" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod trap that is designed to collect gravid female arthropods or their eggs." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "IRO:0000030" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "gravid trap" ; rdfs:subClassOf obo:OBI_0002920 . obo:OBI_0002930 obo:IAO_0000111 "light trap" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod trap that uses light as an attractant." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "MIRO:30000065" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "light trap" ; rdfs:subClassOf obo:OBI_0002920 . obo:OBI_0002931 obo:IAO_0000111 "light trap for indoor use" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A light trap designed to be placed inside a building." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "indoor light trap" ; obo:IAO_0000119 "MIRO:30000009" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "light trap for indoor use" ; rdfs:subClassOf obo:OBI_0002930 . obo:OBI_0002932 obo:IAO_0000111 "light trap for outdoor use" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A light trap designed to be placed outside a building." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "outdoor light trap" ; obo:IAO_0000119 "MIRO:30000010" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "light trap for outdoor use" ; rdfs:subClassOf obo:OBI_0002930 . obo:OBI_0002933 obo:IAO_0000111 "Mosquito Magnet Pro trap" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod trap that is powered by propane and is designed to emit a combination of carbon dioxide, heat, water, and oct-1-en-3-ol attractants while simultaneously using suction to trap arthropods." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "IRO:0000022" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "Mosquito Magnet Pro trap" ; rdfs:subClassOf obo:OBI_0002920 . obo:OBI_0002934 obo:IAO_0000111 "MosquiTRAP" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A gravid trap consisting of an arthropod attractant and adhesive surface." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "IRO:0000140" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "MosquiTRAP" ; rdfs:subClassOf obo:OBI_0002929 . obo:OBI_0002935 obo:IAO_0000111 "New Jersey light trap" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A light trap that is designed to use motorized suction to trap arthropods in a collection bag once they approach the light attractant." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "New Jersey trap" ; obo:IAO_0000119 "IRO:0000031" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "New Jersey light trap" ; rdfs:subClassOf obo:OBI_0002930 . obo:OBI_0002936 obo:IAO_0000111 "Onderstepoort Veterinary Institute light-suction trap" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A light trap that is designed to use motorized suction to trap arthropods in a collection bag once they approach the attractant. The light is supplied by an 8 watt tube, and the fan providing the suction has an 11-centimeter diameter." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "OVI light-suction trap" ; obo:IAO_0000119 "IRO:0000154", "Parasites Vectors 8, 239 (2015)" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "Onderstepoort Veterinary Institute light-suction trap" ; rdfs:subClassOf obo:OBI_0002920 . obo:OBI_0002937 obo:IAO_0000111 "outlet window trap" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod trap that is positioned adjacent to a window of a building and is designed to collect arthropods flying out of the building." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "outlet window trap" ; obo:IAO_0000119 "MIRO:30000020" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "outlet window trap" ; rdfs:subClassOf obo:OBI_0002920 . obo:OBI_0002938 obo:IAO_0000111 "ovitrap" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod trap that consists of a container holding a mesh layer above water and is designed to trap arthropods hatched from eggs dropped over the water by gravid females." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "oviposition trap" ; obo:IAO_0000119 "MIRO:30000016", "VSMO:0001501" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "ovitrap" ; rdfs:subClassOf obo:OBI_0002920 . obo:OBI_0002939 obo:IAO_0000111 "resting arthropod trap" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An arthropod trap that is designed to be attractive to an arthropod as a place to rest during a period of inactivity." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "resting arthropod trap" ; rdfs:subClassOf obo:OBI_0002920 . obo:OBI_0002940 obo:IAO_0000111 "resting box trap" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod trap that consists of a box that is open on one end. The placement of the box and modifications to it are done in such a way that it becomes attractive to an arthropod as a place to rest during a period of inactivity." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "resting box catch" ; obo:IAO_0000119 "IRO:0000021" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "resting box trap" ; rdfs:subClassOf obo:OBI_0002939 . obo:OBI_0002941 obo:IAO_0000111 "resting bucket" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod trap that consists of a bucket, which is lined with fabric and placed on its side, and a wet cloth inside the bucket. The placement of the box and modifications to it are done in such a way that it becomes attractive to an arthropod as a place to rest during a period of inactivity (not actively seeking a host)." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "resting bucket catch" ; obo:IAO_0000119 "IRO:0000141" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "resting bucket" ; rdfs:subClassOf obo:OBI_0002939 . obo:OBI_0002942 obo:IAO_0000111 "Shannon trap" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod trap that is made of cloth and netting and is designed to be suspended from above (e.g. from a tree). It is also designed so that the arthropod enters the trap from beneath, being attracted to some bait, and is prevented from escaping upward by the suspended cloth, which allows them to be collected from the upper interior of the trap." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "shannon trap catch" ; obo:IAO_0000119 "IRO:0000191" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "Shannon trap" ; rdfs:subClassOf obo:OBI_0002920 . obo:OBI_0002943 obo:IAO_0000111 "sticky resting bucket" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod trap that consists of a bucket, which is lined with adhesive and placed on its side, and a wet cloth inside the bucket. The placement of the box and modifications to it are done in such a way that it becomes attractive to an arthropod as a place to rest during a period of inactivity. The trap is designed for arthropods to become caught in the adhesive so that they can be collected." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "sticky resting bucket catch" ; obo:IAO_0000119 "IRO:0000142" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "sticky resting bucket" ; rdfs:subClassOf obo:OBI_0002939 . obo:OBI_0002944 obo:IAO_0000111 "sticky trap" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod trap that is designed to capture arthropods resting on a surface by coating the surface with adhesive." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "sticky trap catch" ; obo:IAO_0000119 "IRO:0000128" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1217" ; a owl:Class ; rdfs:label "sticky trap" ; rdfs:subClassOf obo:OBI_0002939 . obo:OBI_0002945 obo:IAO_0000111 "population based design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design where the selection of the individuals that are included into the study are intended to be representative of all individuals in the a priori defined specific population and is done at the population level or among the population groups, generally to find the cause, incidence or spread of the disease or to see the response to the treatment, nutrition or environment." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "https://link.springer.com/referenceworkentry/10.1007%2F978-1-4419-1005-9_45, EFO_0001430 population based design" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1090" ; a owl:Class ; rdfs:label "population based design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0002946 obo:IAO_0000111 "fluorescence imaging-based apoptosis assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of cytometry assay in which fluorescent dyes are used to label and detect proteins or structures associated with molecular processes of apoptosis." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "url:http://lincsportal.ccs.miami.edu/beta/assays/1" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "fluorescence imaging-based apoptosis assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001501 obo:OBI_0003368 ) ] ] . obo:OBI_0002947 obo:IAO_0000111 "fluorescence imaging-based cell proliferation assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of cell proliferation assay in which fluorescent dyes are ued to label and detect proteins or structures that can be used to count cells." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "fluroescence imaging-based cell count assay" ; obo:IAO_0000119 "url:http://lincsportal.ccs.miami.edu/beta/assays/31" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "fluorescence imaging-based cell proliferation assay" ; rdfs:subClassOf obo:OBI_0000891, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001501 obo:OBI_0003368 ) ] ] . obo:OBI_0002948 obo:IAO_0000111 "fluroescence imaging-based cell cycle state assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of cytometry assay in which fluorescent dyes are used to label and detect proteins or structures associated with particular cell cycle states." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "url:http://lincsportal.ccs.miami.edu/beta/assays/10" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "fluroescence imaging-based cell cycle state assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001501 obo:OBI_0003368 ) ] ] . obo:OBI_0002949 obo:IAO_0000111 "fluorescence imaging-based cell viability assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of cytometry assay in which fluorescent dyes are used to label and detect proteins or structures associated with cell viability." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "url:http://lincsportal.ccs.miami.edu/beta/assays/27" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "fluorescence imaging-based cell viability assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001501 obo:OBI_0003368 ) ] ] . obo:OBI_0002950 obo:IAO_0000111 "fluorescence imaging-based drug synergy assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of cytometry assay in which fluorescent dyes are used to label and detect proteins or structures to determine if drugs applied to cells in combination have a greater effect together than the sum of their separate effects." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "url:http://lincsportal.ccs.miami.edu/beta/assays/7" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "fluorescence imaging-based drug synergy assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001501 obo:OBI_0003368 ) ] ] . obo:OBI_0002951 obo:IAO_0000111 "fluorescence imaging-based cell morphology assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of cytometry assay in which fluorescent dyes are used to label and detect proteins or structures in order to determine cell morphology." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "CFDE", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "fluorescence imaging-based cell morphology assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001501 obo:OBI_0003368 ) ] ] . obo:OBI_0002952 obo:IAO_0000111 "fluorescence imaging multiplex cytological profiling" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of cytometry assay in which fluorescent dyes are used to stain seven major cellular components followed by automatic image capture and analysis which extracts shape, texture, and intensity parameters." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "url:http://lincsportal.ccs.miami.edu/beta/assays/8" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "fluorescence imaging multiplex cytological profiling" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001501 obo:OBI_0003368 ) ] ] . obo:OBI_0002953 obo:IAO_0000111 "protein state assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of assay that measures the quantity and/or identity of proteins in their modficied and unmodified states where modifications include phosphorylation, methylation, acetylation, etc." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "CFDE", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "protein state assay" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0002954 obo:IAO_0000111 "fluorescence imaging-based protein phosphorylation state assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of protein state assay that employs high-throughput microscopy to measure levels of proteins in different phosphorylation states." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "url:http://lincsportal.ccs.miami.edu/beta/assays/15" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "fluorescence imaging-based protein phosphorylation state assay" ; rdfs:subClassOf obo:OBI_0002953, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001501 obo:OBI_0003368 ) ] ] . obo:OBI_0002955 obo:IAO_0000111 "mass spectrometry-based protein state assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of protein state assay that employs mass spectrometry to measure levels of proteins in different phosphorylation states." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "CFDE", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "mass spectrometry-based protein state assay" ; rdfs:subClassOf obo:OBI_0002953, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000470 obo:OBI_0003368 ) ] ] . obo:OBI_0002956 obo:IAO_0000111 "targeted, drug-modulated, mass spectrometry-based protein phoshporylation-state assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of mass spectrometry protein state assay that measures levels of a targeted set of proteins in different phosphorylation states in response to drug perturbations." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "P100 phosphoprotein quantification assay" ; obo:IAO_0000119 "PMID:26912667", "PMID:29655704" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "targeted, drug-modulated, mass spectrometry-based protein phoshporylation-state assay" ; rdfs:subClassOf obo:OBI_0002955 . obo:OBI_0002957 obo:IAO_0000111 "reverse phase protein array profiling assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of protein state assay where tissue or cell samples are lysed and then spotted onto a slide which is probed with antibodies specific to proteins with and without post-translational modifications." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "RPLA assay", "RPPA assay", "reverse phase lysate array profiling assay" ; obo:IAO_0000119 "PMID: 17041095", "PMID:31820393" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "reverse phase protein array profiling assay" ; rdfs:subClassOf obo:OBI_0002953 . obo:OBI_0002958 obo:IAO_0000111 "SWATH-MS protein profiling assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of mass spectrometry assay using a data-independent acquisition method to identify target peptides." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "sequential window acquisition of all theoretical mass spectra protein profiling assay" ; obo:IAO_0000119 "PMID:30104418" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "SWATH-MS protein profiling assay" ; rdfs:subClassOf obo:OBI_0000615, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000470 obo:OBI_0003368 ) ] ] . obo:OBI_0002959 obo:IAO_0000111 "tandem mass tag mass spectrometry assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of tandem mass spectrometry where isotopomer labels are employed for accurate quantification and identification of specific proteins." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "PMID:12713048" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "tandem mass tag mass spectrometry assay" ; rdfs:subClassOf obo:OBI_0003540 . obo:OBI_0002960 obo:IAO_0000111 "fluorescence imaging-based reporter gene assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of reporter gene assay that employs fluorescence imaging to detect a reporter gene's expression." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "CFDE", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "fluorescence imaging-based reporter gene assay" ; rdfs:subClassOf obo:OBI_0002082, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001501 obo:OBI_0003368 ) ] ] . obo:OBI_0002961 obo:IAO_0000111 "global chromatin profiling by mass spectrometry assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of epigenetic modification assay that employs targeted quantitative mass spectrometry to profile modifications of the core histones of chromatin." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "GCP", "global chromatin epigenetic profiling", "global chromatin profiling" ; obo:IAO_0000119 "PMID:25448295" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "global chromatin profiling by mass spectrometry assay" ; rdfs:subClassOf obo:OBI_0002020, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000470 obo:OBI_0003368 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001234 ] . obo:OBI_0002962 obo:IAO_0000111 "kinase inhibitor assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of assay that identifies compounds that inhibit the activity of kinases." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "CFDE", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "kinase inhibitor assay" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0002963 obo:IAO_0000111 "KINOMEscan assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of proprietary kinase inhibitor assay that and employs a panel of kinases against which one can test compounds for their selectivity and potency in interactions with kinases, without the need to add ATP to the reactions." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "url:https://www.discoverx.com/technologies-platforms/competitive-binding-technology/kinomescan-technology-platform" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "KINOMEscan assay" ; rdfs:subClassOf obo:OBI_0002962 . obo:OBI_0002964 obo:IAO_0000111 "KiNativ assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of proprietary in situ kinase inhibitor assay that employs biotinylated acyl phosphates of ATP and ADP." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "url:https://www.kinativ.com/technology.html" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "KiNativ assay" ; rdfs:subClassOf obo:OBI_0002962 . obo:OBI_0002965 obo:IAO_0000111 "landmark transcript profiling assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of transcription profiling assay in which a set of landmark transcripts that have been determined to provide a comprehensive profile of cell activity, plus numerous steady-state controls, are assayed via ligation-mediated amplification followed by capture on fluorescently labeled microspheres followed by detection of fluorescence." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "L1000 mRNA profiling assay" ; obo:IAO_0000119 "PMID:29195078" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "landmark transcript profiling assay" ; rdfs:subClassOf obo:OBI_0000424 . obo:OBI_0002966 obo:IAO_0000111 "microenvironment microarray assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of cytometry assay where cells are incubated for three days with a standardized set of extracellular matrix proteins in combination with various ligands creating varying microenvironment perterbations for the cells. Immunofluorescent imaging of cells is used to measure features such as morphology, metabolism, cell cycle, and nuclear activity." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "MEMA assay" ; obo:IAO_0000119 "PMID:29199020" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "microenvironment microarray assay" ; rdfs:subClassOf obo:OBI_0001977 . obo:OBI_0002967 obo:IAO_0000111 "microwestern meso-scale quantitative western blot assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A western blot assay that provides a high-throughput, sensitive, and quantitative measurement of proteins from numerous samples via an array of small western blots on a single sheet of nitrocellulose." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "PMID:28092050" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "microwestern meso-scale quantitative western blot assay" ; rdfs:subClassOf obo:OBI_0000854 . obo:OBI_0002968 obo:IAO_0000111 "positive/negative ion switching metabolite profiling assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of metabolic profiling assay which employs a hybrid dual quadrupole linear ion trap mass spectrometer for steady-state profiling of endogenous polar metabolites from organic extractions from biological samples." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "positive/negative ion switching metabolomic assay" ; obo:IAO_0000119 "PMID:22498707" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "positive/negative ion switching metabolite profiling assay" ; rdfs:subClassOf obo:OBI_0000366, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000470 obo:OBI_0003368 ) ] ] . obo:OBI_0002969 obo:IAO_0000111 "cyclic immunoflouroescence assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of microscopy assay resulting in highly multiplexed immunofluorescence imaging through sequential rounds of imaging followed by fluorophore inactivation." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "PMID:27925668", "PMID:29993362" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "cyclic immunoflouroescence assay" ; rdfs:subClassOf obo:OBI_0002119 . obo:OBI_0002970 obo:IAO_0000111 "multiplex bead-based protein state immunoassay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of protein state assay in which antibodies attached to different colored beads and fluorescent reporter dye labels are used in a multiplexed mixture to assay for proteins in specific states." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "url:https://www.bio-rad.com/en-us/applications-technologies/multiplex-immunoassays?ID=LUSM0E8UU" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1243" ; obo:IAO_0000234 "CFDE-LINCS" ; a owl:Class ; rdfs:label "multiplex bead-based protein state immunoassay" ; rdfs:subClassOf obo:OBI_0002953 . obo:OBI_0002971 obo:IAO_0000111 "endotracheal tube specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that derives from a biofilm that forms on the inner surface of an endotracheal tube while the tube is in the trachea. The specimen is collected upon removal of the tube from the trachea." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-019-0926-3" ; a owl:Class ; rdfs:label "endotracheal tube specimen" ; rdfs:subClassOf obo:OBI_0001479, [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0006538 ] ) ], [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] . obo:OBI_0002972 obo:IAO_0000111 "endotracheal aspirate specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that derives from a biofilm that forms on the inner surface of an endotracheal tube while the tube is in the trachea. The specimen is collected by suction without removing the tube." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-019-0926-3" ; a owl:Class ; rdfs:label "endotracheal aspirate specimen" ; rdfs:subClassOf obo:OBI_0001479, [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0006538 ] ) ], [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] . obo:OBI_0002975 obo:IAO_0000111 "input protein sequence start site" ; obo:IAO_0000112 "When a new genome is sequenced, the start sites of proteins are identified by comparing the new sequence to that of a reference sequence in a database. The first amino acid of a protein sequence being analyzed is the input protein sequence start site." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The position of the first amino acid in a protein sequence being analyzed (input protein sequence)." ; obo:IAO_0000117 "Emma Griffiths" ; obo:IAO_0000118 "input protein start", "query protein start site" ; obo:IAO_0000119 "Emma Griffiths" ; a owl:Class ; rdfs:label "input protein sequence start site" ; rdfs:subClassOf obo:OBI_0000973 . obo:OBI_0002976 obo:IAO_0000111 "input protein sequence stop site" ; obo:IAO_0000112 "When a new genome is sequenced, the termination sites of proteins are identified by comparing the new sequence to that of a reference sequence in a database. The last amino acid of a protein sequence being analyzed is the input protein sequence stop site." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The position of the last amino acid in a protein sequence being analyzed (input protein sequence)." ; obo:IAO_0000117 "Emma Griffiths" ; obo:IAO_0000118 "input protein stop", "query protein stop site" ; obo:IAO_0000119 "Emma Griffiths" ; a owl:Class ; rdfs:label "input protein sequence stop site" ; rdfs:subClassOf obo:OBI_0000973 . obo:OBI_0002977 obo:IAO_0000111 "input gene sequence start site" ; obo:IAO_0000112 "When a new genome is sequenced, the start sites of genes are identified by comparing the new sequence to that of a reference sequence in a database. The first nucelotide of a gene sequence being analyzed is the input gene sequence start site." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The position of the first nucleotide in a gene sequence being analyzed (input gene sequence)." ; obo:IAO_0000117 "Emma Griffiths" ; obo:IAO_0000118 "input gene start", "query gene start site" ; obo:IAO_0000119 "Emma Griffiths" ; a owl:Class ; rdfs:label "input gene sequence start site" ; rdfs:subClassOf obo:OBI_0000973 . obo:OBI_0002978 obo:IAO_0000111 "input gene sequence stop site" ; obo:IAO_0000112 "When a new genome is sequenced, the termination sites of genes are identified by comparing the new sequence to that of a reference sequence in a database. The last nucelotide of a gene sequence being analyzed is the input gene sequence stop site." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The position of the last nucelotide in a gene sequence being analyzed (input gene sequence)." ; obo:IAO_0000117 "Emma Griffiths" ; obo:IAO_0000118 "input gene stop", "query gene stop site" ; obo:IAO_0000119 "Emma Griffiths" ; a owl:Class ; rdfs:label "input gene sequence stop site" ; rdfs:subClassOf obo:OBI_0000973 . obo:OBI_0002979 obo:IAO_0000111 "reference protein sequence start site" ; obo:IAO_0000112 "When a new genome is sequenced, the start sites of proteins are identified by comparing the new sequence to that of a reference sequence in a database. The first amino acid of a protein sequence being used for comparison is the reference protein sequence start site." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The position of the first amino acid in a reference protein sequence (sequence being used for comparison)." ; obo:IAO_0000117 "Emma Griffiths" ; obo:IAO_0000118 "reference protein start", "subject protein start site" ; obo:IAO_0000119 "Emma Griffiths" ; a owl:Class ; rdfs:label "reference protein sequence start site" ; rdfs:subClassOf obo:OBI_0000973 . obo:OBI_0002980 obo:IAO_0000111 "reference protein sequence stop site" ; obo:IAO_0000112 "When a new genome is sequenced, the termination sites of proteins are identified by comparing the new sequence to that of a reference sequence in a database. The last amino acid of a protein sequence used for comparison is the reference protein sequence stop site." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The position of the last amino acid in a reference protein sequence (sequence being used for comparison)." ; obo:IAO_0000117 "Emma Griffiths" ; obo:IAO_0000118 "reference protein stop", "subject protein stop site" ; obo:IAO_0000119 "Emma Griffiths" ; a owl:Class ; rdfs:label "reference protein sequence stop site" ; rdfs:subClassOf obo:OBI_0000973 . obo:OBI_0002981 obo:IAO_0000111 "reference gene sequence start site" ; obo:IAO_0000112 "When a new genome is sequenced, the start sites of genes are identified by comparing the new sequence to that of a reference sequence in a database. The first nucelotide of a gene sequence used for comparison is the reference gene sequence start site." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The position of the first nucleotide in a reference gene sequence (sequence being used for comparison)." ; obo:IAO_0000117 "Emma Griffiths" ; obo:IAO_0000118 "reference gene start", "subject gene start site" ; obo:IAO_0000119 "Emma Griffiths" ; a owl:Class ; rdfs:label "reference gene sequence start site" ; rdfs:subClassOf obo:OBI_0000973 . obo:OBI_0002982 obo:IAO_0000111 "reference gene sequence stop site" ; obo:IAO_0000112 "When a new genome is sequenced, the termination sites of genes are identified by comparing the new sequence to that of a reference sequence in a database. The last nucelotide of a gene sequence used for comparison is the reference gene sequence stop site." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The position of the last nucelotide in a reference sequence (sequence being used for comparison)." ; obo:IAO_0000117 "Emma Griffiths" ; obo:IAO_0000118 "reference gene stop", "subject gene stop site" ; obo:IAO_0000119 "Emma Griffiths" ; a owl:Class ; rdfs:label "reference gene sequence stop site" ; rdfs:subClassOf obo:OBI_0000973 . obo:OBI_0002983 obo:IAO_0000111 "altitude measurement datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A length measurement datum between a point at sea or ground level and some point above it." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "Adapted from https://www.merriam-webster.com/dictionary/altitude" ; a owl:Class ; rdfs:label "altitude measurement datum" ; rdfs:subClassOf obo:IAO_0000408 . obo:OBI_0002984 obo:IAO_0000111 "capture Hi-C assay" ; obo:IAO_0000112 "PMID:29979818 Chromosome conformation capture (3C), coupled with next-generation sequencing (Hi-C), provides a means for deciphering not only the principles underlying genome folding and architecture, but more broadly, the role 3D chromatin structure plays in gene regulation and the replication and repair of DNA." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Hi-C assay in which a selection step is performed on ligated fragments in order to enrich for ligation products containing specific regions of interest." ; obo:IAO_0000117 "Bonita Lam" ; obo:IAO_0000118 "cHi-C" ; obo:IAO_0000119 "PMID:29979818" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1251" ; a owl:Class ; rdfs:label "capture Hi-C assay" ; rdfs:subClassOf obo:OBI_0002440 . obo:OBI_0002985 obo:IAO_0000111 "magnetic resonance imaging assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An imaging assay in which nuclear magnetic resonance is used to produce information about the interior structure and composition of an input material entity." ; obo:IAO_0000117 "Alexander D. Bartnik, ORCID:0000-0001-9676-7377", "Alexander D. Diehl, ORCID:0000-0001-9990-8331", "Lauren M. Wishnie, ORCID:0000-0002-7245-3450", "Lucas M. Serra, ORCID:0000-0002-2104-0568", "Mackenzie T. Smith, ORCID:0000-0002-9821-4132", "Rebecca Jackson", "William D. Duncan, ORCID:0000-0001-9625-1899" ; obo:IAO_0000118 "MRI" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Magnetic_resonance_imaging" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1290" ; a owl:Class ; rdfs:label "magnetic resonance imaging assay" ; rdfs:subClassOf obo:OBI_0000185, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000566 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000566 ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000059 ; owl:someValuesFrom obo:OBI_0003332 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0003330 ] ] . obo:OBI_0002986 obo:IAO_0000111 "computed tomography imaging assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An imaging assay that uses a series of X-ray images to produce information about the interior structure and composition of an input material entity." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "CAT scan", "CT scan", "computed tomography scan" ; obo:IAO_0000119 "url:https://www.mayoclinic.org/tests-procedures/ct-scan/about/pac-20393675" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1290" ; a owl:Class ; rdfs:label "computed tomography imaging assay" ; rdfs:subClassOf obo:OBI_0000185, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000982 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000982 ] ) ] . obo:OBI_0002987 obo:IAO_0000111 "positron emission tomography imaging assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An imaging assay in which positron-emitting radionuclides are used to visualize functional processes of an input material entity." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "PET scan", "positron emission tomography scan" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Positron_emission_tomography" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1290" ; a owl:Class ; rdfs:label "positron emission tomography imaging assay" ; rdfs:subClassOf obo:OBI_0000185, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000933 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000933 ] ) ] . obo:OBI_0002988 obo:IAO_0000111 "duration of specimen collection" ; obo:IAO_0000112 "Specimen collection duration of 3 nights that a trap is set out for collection of mosquitoes. Urine collected over a 24 hour period of specimen collection duration." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A time measurement datum that is the count of collection cycles over which a specimen collection process occurs." ; obo:IAO_0000118 "specimen collection duration" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "specimen collection duration" ; rdfs:subClassOf obo:IAO_0000416 . obo:OBI_0002989 obo:IAO_0000111 "material supplier" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A person or organization that provides material supplies to other people or organizations." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1289" ; a owl:Class ; rdfs:label "material supplier" ; rdfs:subClassOf obo:BFO_0000040 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:unionOf (obo:NCBITaxon_9606 obo:OBI_0000245 ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000018 ] ) ] . obo:OBI_0002990 obo:IAO_0000111 "T cell receptor repertoire sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A sequencing assay that determines the sequences of DNA or RNA molecules that encode the repertoire of T cell receptors within an input sample." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "TCR repertoire sequencing assay", "bulk TCR assay" ; obo:IAO_0000119 "doi:10.1186/s12896-017-0379-9" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1307" ; a owl:Class ; rdfs:label "T cell receptor repertoire sequencing assay" ; rdfs:subClassOf obo:OBI_0600047 . obo:OBI_0002991 obo:IAO_0000111 "B cell receptor repertoire sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A sequencing assay that determines the sequence of a DNA or RNA molecules that encode the repertoire of B cell receptors within an input sample." ; obo:IAO_0000117 "Rebecca Jackson" ; obo:IAO_0000118 "Antibody repertoire sequencing assay", "BCR repertoire sequencing assay", "bulk BCR assay" ; obo:IAO_0000119 "doi:10.1186/s12896-017-0379-9" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1307" ; a owl:Class ; rdfs:label "B cell receptor repertoire sequencing assay" ; rdfs:subClassOf obo:OBI_0600047 . obo:OBI_0002992 obo:IAO_0000111 "prevalence of pathogen in specimens" ; obo:IAO_0000112 "prevalence of Plasmodium falciparum in Mosquito samples assayed by PCR" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item that is the frequency of detection of a specified pathogenic organism in collected specimens." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000118 "prevalence of pathogen" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "prevalence of pathogen in specimens" ; rdfs:subClassOf obo:IAO_0000027 . obo:OBI_0002993 obo:IAO_0000111 "prevalence of blood meal specimens from a host organism" ; obo:IAO_0000112 "prevalence of blood meal host organism in specimens measured as % of blood meal specimens collected from mosquitoes that had human blood as a meal." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item that is the frequency of blood whose source is from a specified host organism in collected blood meal specimens." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000118 "host blood index" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "prevalence of blood meal specimens from a host organism" ; rdfs:subClassOf obo:IAO_0000027 . obo:OBI_0002994 obo:IAO_0000111 "presence of blood from host organism in blood meal specimen" ; obo:IAO_0000112 "presence of blood meal host organism indicated by boolean values of yes or no." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item that indicates whether blood in a blood meal specimen came from a specified host organism." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000118 "presence of blood meal host organism" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "presence of blood from host organism in blood meal specimen" ; rdfs:subClassOf obo:IAO_0000027 . obo:OBI_0002995 obo:IAO_0000111 "blood meal source organism" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism that is the source of a blood meal." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000118 "blood meal host organism" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "blood meal source organism" ; rdfs:subClassOf obo:OBI_0100026, [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0002996 ] ) ] . obo:OBI_0002996 obo:IAO_0000111 "blood meal source role" ; obo:IAO_0000112 "A mosquito feeds on a human whereby the human acquires the blood meal source role for the mosquito blood meal." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A role borne by an organism that is gained during a process in which another organism ingests blood as food from the organism." ; obo:IAO_0000116 "Will deprecate this term in VEuPathDB ontology once in OBI." ; obo:IAO_0000117 "Chris Stoeckert" ; obo:IAO_0000119 "http://purl.obolibrary.org/obo/EUPATH_0000791" ; a owl:Class ; rdfs:label "blood meal source role" ; rdfs:subClassOf obo:BFO_0000023 . obo:OBI_0002997 obo:IAO_0000111 "arthropod attractor role" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A role of a material entity realized in drawing an arthropod in the direction of the material." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "attractant" ; obo:IAO_0000119 "IRO:0000034" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1302" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "arthropod attractor role" ; rdfs:subClassOf obo:BFO_0000023 . obo:OBI_0002998 obo:IAO_0000111 "arthropod collection process with automated identification" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod specimen collection process that involves a device that produces data specifying the types of arthropod collected." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1302" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "arthropod collection process with automated identification" ; rdfs:subClassOf obo:OBI_0002913 . obo:OBI_0002999 obo:IAO_0000111 "gravid female arthropod specimen collection process" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod specimen collection process that has the objective of collecting gravid female arthropods." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1302" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "gravid female arthropod specimen collection process" ; rdfs:subClassOf obo:OBI_0002913 . obo:OBI_0003000 obo:IAO_0000111 "resting flight-capable arthropod specimen collection process" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod specimen collection process that occurs while an arthropod that is capable of flight is resting outdoors during a period of inactivity." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VSMO:0000514" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1302" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "resting flight-capable arthropod specimen collection process" ; rdfs:subClassOf obo:OBI_0002913 . obo:OBI_0003001 obo:IAO_0000111 "daytime arthropod specimen collection by aspiration" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod specimen collection by aspiration that occurs in the daytime." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1302" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "daytime arthropod specimen collection by aspiration" ; rdfs:subClassOf obo:OBI_0002912 . obo:OBI_0003002 obo:IAO_0000111 "arthropod resting in human house specimen collection by aspiration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An arthropod specimen collection by aspiration that catches specimens resting inside a human house." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1302" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "arthropod resting in human house specimen collection by aspiration" ; rdfs:subClassOf obo:OBI_0002912 . obo:OBI_0003003 obo:IAO_0000111 "landing arthropod specimen collection process" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod specimen collection process that occurs while the arthropods land on a surface." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "collection of landing insects" ; obo:IAO_0000119 "VSMO:0001457" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1302" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "landing arthropod specimen collection process" ; rdfs:subClassOf obo:OBI_0002904 . obo:OBI_0003004 obo:IAO_0000111 "flying adult arthropod collection process by passive interception" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An adult arthropod specimen collection process that has the objective of collecting arthropods capable of flight, through the use of a barrier trap." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1302" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "flying adult arthropod collection process by passive interception" ; rdfs:subClassOf obo:OBI_0002904 . obo:OBI_0003005 obo:IAO_0000111 "device for collection of resting adult arthropods" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that is designed to provide a solid surface that is attractive to an arthropod as a place to rest during a period of inactivity." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VSMO:0001355" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1302" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "device for collection of resting adult arthropods" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0003006 obo:IAO_0000111 "well net for arthropod immatures" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A device that is designed for the collection of arthropod larvae or pupae from water and consists of a conical net." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1302" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "well net for arthropod immatures" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0003007 obo:IAO_0000111 "arthropod trap containing small non-human animal bait" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod trap that uses as attractant an animal that is not human and is the size of a chicken or smaller." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "trap containing small non-human animal bait" ; obo:IAO_0000119 "VSMO:0001595" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1302" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "arthropod trap containing small non-human animal bait" ; rdfs:subClassOf obo:OBI_0002920 . obo:OBI_0003008 obo:IAO_0000111 "trap for emerging adult arthropods" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod trap that is designed to trap an arthropod as it emerges from water at the beginning of its adult stage." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "American Midland Naturalist, Vol. 97, No. 2 (Apr., 1977), pp. 381-389", "VSMO:0001352" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1302" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "trap for emerging adult arthropods" ; rdfs:subClassOf obo:OBI_0002920 . obo:OBI_0003009 obo:IAO_0000111 "ferritin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures ferritin" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5557" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "ferritin assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0070288 ] ] ) ] . obo:OBI_0003010 obo:IAO_0000111 "fibrinogen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures fibrinogen" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5558" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "fibrinogen assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0005577 ] ] ) ] . obo:OBI_0003011 obo:IAO_0000111 "iron assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of iron" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5559" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "iron assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_24875 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_24875 ] ) ] ) ] . obo:OBI_0003012 obo:IAO_0000111 "ionized calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of ionized calcium" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5561" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "ionized calcium assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39124 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39124 ] ) ] ) ] . obo:OBI_0003013 obo:IAO_0000111 "transferrin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of transferrin" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5562" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "transferrin assay" ; rdfs:subClassOf obo:OBI_2100023 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000016261 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000016261 ] ) ] ) ] . obo:OBI_0003014 obo:IAO_0000111 "uric acid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of uric acid" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5563" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "uric acid assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_27226 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_27226 ] ) ] ) ] . obo:OBI_0003015 obo:IAO_0000111 "globulin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of globulin" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5564" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "globulin assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_166899 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_166899 ] ) ] ) ] . obo:OBI_0003016 obo:IAO_0000111 "myelocyte assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the abundance and/or characteristics of myelocytes" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5565" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "myelocyte assay" ; rdfs:subClassOf obo:OBI_0001977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001977 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0002193 ] ] ) ] . obo:OBI_0003017 obo:IAO_0000111 "metamyelocyte assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the abundance and/or characteristics of metamyelocytes" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5566" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "metamyelocyte assay" ; rdfs:subClassOf obo:OBI_0001977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001977 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0002192 ] ] ) ] . obo:OBI_0003018 obo:IAO_0000111 "hematocrit assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the proportion of red blood cells" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5567" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "hematocrit assay" ; rdfs:subClassOf obo:OBI_0001977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001977 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000232 ] ] ) ] . obo:OBI_0003019 obo:IAO_0000111 "promyelocyte assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the abundance and/or characteristics of promyelocytes" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5568" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "promyelocyte assay" ; rdfs:subClassOf obo:OBI_0001977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001977 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000836 ] ] ) ] . obo:OBI_0003021 obo:IAO_0000111 "basophil assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the abundance and/or characteristics of basophils" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5569" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "basophil assay" ; rdfs:subClassOf obo:OBI_0001977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001977 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000767 ] ] ) ] . obo:OBI_0003022 obo:IAO_0000111 "neutrophil assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the abundance and/or characteristics of neutrophils" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5570" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "neutrophil assay" ; rdfs:subClassOf obo:OBI_0001977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001977 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000775 ] ] ) ] . obo:OBI_0003023 obo:IAO_0000111 "eosinophil assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the abundance and/or characteristics of eosinophils" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5571" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "eosinophil assay" ; rdfs:subClassOf obo:OBI_0001977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001977 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000771 ] ] ) ] . obo:OBI_0003024 obo:IAO_0000111 "lymphocyte assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the abundance and/or characteristics of lymphocytes" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5572" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "lymphocyte assay" ; rdfs:subClassOf obo:OBI_0001977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001977 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000542 ] ] ) ] . obo:OBI_0003025 obo:IAO_0000111 "monocyte assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the abundance and/or characteristics of monocytes" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5573" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "monocyte assay" ; rdfs:subClassOf obo:OBI_0001977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001977 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000576 ] ] ) ] . obo:OBI_0003026 obo:IAO_0000111 "reticulocyte assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the abundance and/or characteristics of reticulocytes" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5574" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "reticulocyte assay" ; rdfs:subClassOf obo:OBI_0001977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001977 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000558 ] ] ) ] . obo:OBI_0003027 obo:IAO_0000111 "macrophage assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the abundance and/or characteristics of macrophages" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5577" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "macrophage assay" ; rdfs:subClassOf obo:OBI_0001977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001977 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000235 ] ] ) ] . obo:OBI_0003028 obo:IAO_0000111 "platelet assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the abundance and/or characteristics of platelets" ; obo:IAO_0000117 "James A. Overton, ORCID:0000-0001-5139-5578" ; obo:IAO_0000119 "OBI" ; a owl:Class ; rdfs:label "platelet assay" ; rdfs:subClassOf obo:OBI_0001977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001977 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000233 ] ] ) ] . obo:OBI_0003029 obo:IAO_0000111 "barcode target locus role" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An evaluant role that is realized in a taxonomic diversity assessment by targeted gene survey involving sequencing a small defined region of genome amplified by PCR." ; obo:IAO_0000117 "Chris Stoeckert https://orcid.org/0000-0002-5714-991X" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1325" ; a owl:Class ; rdfs:label "barcode target locus role" ; rdfs:subClassOf obo:OBI_0000067, [ a owl:Restriction ; owl:onProperty obo:BFO_0000054 ; owl:someValuesFrom obo:OBI_0001960 ] . obo:OBI_0003030 obo:IAO_0000111 "oligonucleotide primer set" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A processed material that consists of oligonucleotides that bear a primer role." ; obo:IAO_0000117 "Chris Stoeckert https://orcid.org/0000-0002-5714-991X" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1325" ; a owl:Class ; rdfs:label "oligonucleotide primer set" ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:OBI_0000405 ] . obo:OBI_0003031 obo:IAO_0000111 "fluorogenic PCR assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A polymerase chain reaction assay that uses target specific probes labeled with fluorogenic chromophores." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "TaqMan" ; obo:IAO_0000119 "MIRO:20000102" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1320" ; a owl:Class ; rdfs:label "fluorogenic PCR assay" ; rdfs:subClassOf obo:OBI_0002692 . obo:OBI_0003032 obo:IAO_0000111 "genotyping by PCR assay" ; obo:IAO_0000112 "genotyping by PCR assay to identify microsatellites, chromosomal inversions and targeted assays of known resistance loci." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A genotyping assay that uses polymerase chain reaction." ; obo:IAO_0000117 "Chris Stoeckert, ORCID:0000-0002-5714-991X", "Jie Zheng, ORCID:0000-0002-2999-0103" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1348" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "genotyping by PCR assay" ; rdfs:subClassOf obo:OBI_0000435, obo:OBI_0002692, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000415 ] . obo:OBI_0003033 obo:IAO_0000111 "cleavage under targets and release using nuclease assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of DNA sequencing assay employing in situ chromatin profiling in which antibody-targeted controlled cleavage by micrococcal nuclease releases specific protein-DNA complexes into the the supernatant for sequencing." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "CUT&RUN assay" ; obo:IAO_0000119 "url:https://elifesciences.org/articles/21856" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1192" ; obo:IAO_0000234 "bonitalam" ; a owl:Class ; rdfs:label "cleavage under targets and release using nuclease assay" ; rdfs:subClassOf obo:OBI_0000626 . obo:OBI_0003034 obo:IAO_0000111 "cleavage under targets and tagmentation" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A type of DNA sequencing assay employing in situ chromatin profiling in which a chromatin protein is bound in situ by a specific antibody, which then tethers to a protein A-Tn5 hyperactive transposase fusion protein (pA-Tn5) loaded with sequence adapters. Activation of pA-Tn5 results in factor-targeted tagmentation, generating fragments ready for PCR enrichment and DNA sequencing." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "CUT&Tag assay" ; obo:IAO_0000119 "url:https://www.nature.com/articles/s41467-019-09982-5" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1192" ; obo:IAO_0000234 "bonitalam" ; a owl:Class ; rdfs:label "cleavage under targets and tagmentation" ; rdfs:subClassOf obo:OBI_0000626 . obo:OBI_0003035 obo:IAO_0000111 "coma severity assay" ; obo:IAO_0000112 "Examining a patient and grading their coma status on the Blantyre or Glasgow coma scale." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A physical examination of an organism that has the objective to determine the severity of coma in a patient." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1357" ; obo:IAO_0000234 "John Judkins" ; a owl:Class ; rdfs:label "coma severity assay" ; rdfs:subClassOf obo:OBI_0002441 . obo:OBI_0003036 obo:IAO_0000111 "Plasmodium gametocyte detection assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that detects Plasmodium gametocytes in a specimen." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng", "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1322" ; a owl:Class ; rdfs:label "Plasmodium gametocyte detection assay" ; rdfs:subClassOf obo:OBI_0003038, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0100051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OPL_0000267 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OPL_0000267 ] ) ] . obo:OBI_0003037 obo:IAO_0000111 "malaria rapid diagnosis assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that is quick and easy in the diagnosis of malaria by detecting evidence of malaria parasites (antigens) in human blood." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng" ; obo:IAO_0000118 "malaria rapid diagnosis test" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1322" ; a owl:Class ; rdfs:label "malaria rapid diagnosis assay" ; rdfs:subClassOf obo:OBI_0003038, obo:OBI_0003040, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000655 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000655 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NCBITaxon_5820 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:NCBITaxon_5820 ] ) ] . obo:OBI_0003038 obo:IAO_0000111 "parasite detection assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that detects parasite in a specimen." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1322" ; a owl:Class ; rdfs:label "parasite detection assay" ; rdfs:subClassOf obo:OBI_0003498, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0100051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OPL_0000232 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OPL_0000232 ] ) ] . obo:OBI_0003039 obo:IAO_0000111 "feces microbiology assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that detects microorganisms in a feces specimen." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "stool test for microorganisms" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1322" ; a owl:Class ; rdfs:label "feces microbiology assay" ; rdfs:subClassOf obo:OBI_0003237, obo:OBI_0003498, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002503 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002503 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0100026 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100026 ] ) ] . obo:OBI_0003040 obo:IAO_0000111 "blood assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that has a blood specimen as evaulant." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1322" ; a owl:Class ; rdfs:label "blood assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000655 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000655 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] ) ] . obo:OBI_0003041 obo:IAO_0000111 "falcivax rapid diagnostic test" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A parasite detection assay that can quickly establish the diagnosis of P. falciparum or P. vivax malaria infection by detecting the antigens in a person's blood." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1322" ; a owl:Class ; rdfs:label "falcivax rapid diagnostic test" ; rdfs:subClassOf obo:OBI_0003038, obo:OBI_0003040, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000655 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000655 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0003042 obo:IAO_0000111 "optimal-IT rapid diagnostic test" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A parasite detection assay that is rapid, sensitive, and able to differentiate between P. falciparum and other malaria parasites." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1322" ; a owl:Class ; rdfs:label "optimal-IT rapid diagnostic test" ; rdfs:subClassOf obo:OBI_0003038, obo:OBI_0003040, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000655 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000655 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0003043 obo:IAO_0000111 "urine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that has a urine specimen as evaluant." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1322" ; a owl:Class ; rdfs:label "urine assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000651 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000651 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] ) ] . obo:OBI_0003044 obo:IAO_0000111 "parasite species identification by PCR assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A parasite detection by PCR assay that identifies the species of parasite." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1322" ; a owl:Class ; rdfs:label "parasite species identification by PCR assay" ; rdfs:subClassOf obo:OBI_0003045, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002692 obo:OBI_0003368 ) ] ] . obo:OBI_0003045 obo:IAO_0000111 "parasite detection by PCR assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A parasite detection assay that uses PCR." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1322" ; a owl:Class ; rdfs:label "parasite detection by PCR assay" ; rdfs:subClassOf obo:OBI_0002692, obo:OBI_0003038, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000415 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002692 obo:OBI_0003368 ) ] ] . obo:OBI_0003046 obo:IAO_0000111 "free-standing window trap" ; obo:IAO_0000112 "Jonsson developed a free-standing window trap consisting of a 16 x 20-cm perspex box, 16 cm high and divided in the middle by a 20 x 36-cm sheet of perspex (window). The two compartments of the box are filled to a depth of about 12 cm with 4-6% formalin containing a few drops of detergent; in winter ethylene glycol can be added to prevent freezing. One or two holes drilled in one side of the box at 12 cm and covered with fine netting prevent the trap overflowing after heavy rain. Traps are mounted on aluminium poles. Flying insects on hitting the transparent vertical plastic window fall into the formalin. The window trap may catch vectors that are seeking a host or moving for other purposes. [ISBN:9781402066658]" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod trap that consists of a transparent window placed in a box that holds a liquid solution deadly to arthropods. This trap is designed to stop an arthropod in flight, causing it to fall into the liquid and die." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000119 "VSMO:0001649" ; a owl:Class ; rdfs:label "free-standing window trap" ; rdfs:subClassOf obo:OBI_0002920 . obo:OBI_0003048 obo:IAO_0000111 "BG-lure scent dispenser" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device manufactured by BioGents that is designed for operation with the BG-Sentinel trap and releases an attractant that mimics the scent of human skin." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "BG-lure" ; obo:IAO_0000119 "IRO:0001060" ; a owl:Class ; rdfs:label "BG-lure scent dispenser" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:hasValue obo:OBI_0002903 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003049 obo:IAO_0000111 "hand-held sweep net" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that consists of a network of mesh and is designed to capture adult arthropods." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000119 "VSMO:0001522" ; a owl:Class ; rdfs:label "hand-held sweep net" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0003050 obo:IAO_0000111 "Centers for Disease Control and Prevention gravid trap" ; obo:IAO_0000112 "The original trap CDC gravid trap (or gravid trap of Reiter) consists of a 3 inch diameter PVC inlet tube housing a 6 V motor, as used in CDC traps, on which is mounted a four-bladed 3 inch counter-clockwise fan. The inlet tube is clamped between two vertical wooden boards that fit over a black plastic box (18.5 x 14.0 x 6.5 inches). A plastic 12 inch long PVC chimney slots into the upper end of the inlet tube. The top half consists of three struts that fit into and support a netting collecting bag. For this the middle of the collecting bag is reinforced with a circular patch of denim cloth. The oviposition attractant is made by adding 1 lb of hay and 1 oz each of dried brewer's yeast and lactalbumen powder to 30 gallons of tap water. This infusion is allowed to mature for 5 days. This original gravid mosquito trap of Reiter suffers from certain limitations, namely up to 10% of the catch of adults is damaged by passing through the fan blades, and adults tend to die of desiccation. [ISBN:9781402066658]" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A gravid trap that consists of a pan holding a hay infusion, motorized fan, and collection bag. This trap is designed to attract gravid female arthropods to the infused material, which would serve as an oviposition medium, and then draw them into the bag with the current generated by the fan." ; obo:IAO_0000117 "VEuPathDB" ; obo:IAO_0000118 "CDC gravid trap" ; obo:IAO_0000119 "VSMO:0001510" ; a owl:Class ; rdfs:label "Centers for Disease Control and Prevention gravid trap" ; rdfs:subClassOf obo:OBI_0002929 . obo:OBI_0003051 obo:IAO_0000111 "egg specimen collection process" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod specimen collection process in which the arthropods are in the embryo stage." ; obo:IAO_0000117 "VEuPath" ; obo:IAO_0000118 "collection of eggs" ; obo:IAO_0000119 "MIRO:30000049" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1322" ; a owl:Class ; rdfs:label "egg specimen collection process" ; rdfs:subClassOf obo:OBI_0002907 . obo:OBI_0003052 obo:IAO_0000111 "larval specimen collection process" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod specimen collection process in which the arthropods are in the larval stage." ; obo:IAO_0000117 "VEuPath" ; obo:IAO_0000118 "collection of larvae" ; obo:IAO_0000119 "MIRO:30000022" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1322" ; a owl:Class ; rdfs:label "larval specimen collection process" ; rdfs:subClassOf obo:OBI_0002907 . obo:OBI_0003053 obo:IAO_0000111 "pupal specimen collection process" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arthropod specimen collection process in which the arthropods are in the pupal stage." ; obo:IAO_0000117 "VEuPath" ; obo:IAO_0000118 "collection of pupae" ; obo:IAO_0000119 "MIRO:30000050" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1322" ; a owl:Class ; rdfs:label "pupal specimen collection process" ; rdfs:subClassOf obo:OBI_0002907 . obo:OBI_0003054 obo:IAO_0000111 "blood specimen in vacutainer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A blood specimen that is located in a vacutainer." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "Vacutainer sample" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "blood specimen in vacutainer" ; rdfs:subClassOf obo:OBI_2000009, [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ], [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] . obo:OBI_0003055 obo:IAO_0000111 "blood specimen on filter paper" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A blood specimen that is located on a filter paper." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng" ; obo:IAO_0000118 "Filter paper sample" ; obo:IAO_0000119 "Penn Group" ; a owl:Class ; rdfs:label "blood specimen on filter paper" ; rdfs:subClassOf obo:OBI_2000009, [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ], [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] . obo:OBI_0003056 obo:IAO_0000111 "proportion mapped reads" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A sequence datum that is the specified output of a read mapping and is the ratio of the count of mapped reads to the total count of reads." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "proportion mapped reads" ; rdfs:subClassOf obo:OBI_0000973 . obo:OBI_0003057 obo:IAO_0000111 "antibiotic administration process" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Administering substance in vivo where an antibiotic substance is administered to a living organism." ; obo:IAO_0000117 "Chris Stoeckert", "Cristian Cocos", "Jie Zheng" ; obo:IAO_0000119 "Penn Group" ; a owl:Class ; rdfs:label "antibiotic administration process" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000319 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:IDO_0000562 ] ) ] ] . obo:OBI_0003063 obo:IAO_0000111 "insecticide resistance datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item that is about resistance to an insecticide." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "insecticide resistance datum" ; rdfs:subClassOf obo:IAO_0000027 . obo:OBI_0003064 obo:IAO_0000111 "organism detection datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item that is the specified output of an organism detection assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "organism detection datum" ; rdfs:subClassOf obo:IAO_0000027 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:IAO_0000027 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003498 ] ) ] . obo:OBI_0003066 obo:IAO_0000111 "easting coordinate measurement datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A one dimensional Cartesian spatial coordinate datum that is the eastward component of a distance from a point on a map projection." ; obo:IAO_0000116 "Easting and northing coordinates are commonly measured in meters from a horizontal datum." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Grid_reference_system" ; a owl:Class ; rdfs:label "easting coordinate measurement datum" ; rdfs:subClassOf obo:IAO_0000401 . obo:OBI_0003067 obo:IAO_0000111 "northing coordinate measurement datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A one dimensional Cartesian spatial coordinate datum that is the northward component of a distance from a point on a map projection." ; obo:IAO_0000116 "Easting and northing coordinates are commonly measured in meters from a horizontal datum." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Grid_reference_system" ; a owl:Class ; rdfs:label "northing coordinate measurement datum" ; rdfs:subClassOf obo:IAO_0000401 . obo:OBI_0003068 obo:IAO_0000111 "clinical study center" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Organization that undertakes a clinical study at some point in time." ; obo:IAO_0000117 "Chris Stoeckert", "Cristian Cocos", "Jie Zheng" ; obo:IAO_0000119 "Penn Group" ; a owl:Class ; rdfs:label "clinical study center" ; rdfs:subClassOf obo:OBI_0000245 . obo:OBI_0003069 obo:IAO_0000111 "sequencing protocol" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A protocol that, when concretized, is realized in an assay that uses chemical or biological means to infer the sequence of a biomaterial." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "sequencing protocol" ; rdfs:subClassOf obo:OBI_0000272 . obo:OBI_0003070 obo:IAO_0000111 "specimen collection protocol" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A protocol that specifies processes to fulfill a specimen collection objective." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "specimen collection protocol" ; rdfs:subClassOf obo:OBI_0000272, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000684 ] . obo:OBI_0003071 obo:IAO_0000111 "participant identifier" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A symbol that denotes a participant under investigation." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "participant identifier" ; rdfs:subClassOf obo:IAO_0000028 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:IAO_0000028 [ a owl:Restriction ; owl:onProperty obo:IAO_0000219 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000097 ] ] ) ] . obo:OBI_0003072 obo:IAO_0000111 "axillary temperature measurement datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A temperature measurement datum that is about an axilla." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "axillary temperature measurement datum" ; rdfs:subClassOf obo:OBI_0003079 . obo:OBI_0003073 obo:IAO_0000111 "organismal body temperature measurement datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A temperature measurement datum that is about an organism." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng" ; obo:IAO_0000119 "Penn Group" ; a owl:Class ; rdfs:label "organismal body temperature measurement datum" ; rdfs:subClassOf obo:OBI_0003079 . obo:OBI_0003074 obo:IAO_0000111 "common name of organism" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A textual entity refers to a taxon or organism that is based on the normal language of everyday life; this kind of name is often contrasted with the scientific name for the same organism, which is Latinized." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Common_name" ; a owl:Class ; rdfs:label "common name of organism" ; rdfs:subClassOf obo:IAO_0000300, [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0100026 ; owl:onProperty obo:IAO_0000219 ] . obo:OBI_0003075 obo:IAO_0000111 "age since birth at time of enrollment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An age since birth measurement datum at the time of subject enrollment." ; obo:IAO_0000117 "Jie Zheng" ; obo:IAO_0000119 "Penn Group" ; a owl:Class ; rdfs:label "age since birth at time of enrollment" ; rdfs:subClassOf obo:OBI_0001169 . obo:OBI_0003076 obo:IAO_0000111 "age since birth at time of visit" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An age since birth measurement datum at the time of a clinical visit." ; obo:IAO_0000117 "Chris Stoeckert", "Grant Dorsey", "Jie Zheng", "Shon Cade" ; obo:IAO_0000119 "Penn Group" ; a owl:Class ; rdfs:label "age since birth at time of visit" ; rdfs:subClassOf obo:OBI_0001169 . obo:OBI_0003077 obo:IAO_0000111 "entomological data item" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item that is about a collection of insects." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "entomological measurement datum" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "entomological data item" ; rdfs:subClassOf obo:IAO_0000027 . obo:OBI_0003079 obo:IAO_0000111 "temperature measurement datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A scalar measurement datum that is the result of measuring temperature." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "temperature measurement datum" ; rdfs:subClassOf obo:IAO_0000032 . obo:OBI_0003080 obo:IAO_0000111 "organismal body temperature measurement assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that detects body temperature of an organism." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1322" ; a owl:Class ; rdfs:label "organismal body temperature measurement assay" ; rdfs:subClassOf obo:OBI_0002140, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0100026 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0003081 obo:IAO_0000111 "extraction date" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A time measurement datum that specifies when some material was extracted from an input material." ; obo:IAO_0000117 "Chris Stoeckert, ORCID: 0000-0002-5714-991X" ; obo:IAO_0000119 "FLU, VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1286" ; a owl:Class ; rdfs:label "extraction date" ; rdfs:subClassOf obo:IAO_0000416 . obo:OBI_0003082 obo:IAO_0000111 "extraction duration time" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A time measurement datum that is the result of measuring the duration of an extraction process." ; obo:IAO_0000117 "Chris Stoeckert, ORCID: 0000-0002-5714-991X" ; obo:IAO_0000119 "Meredith Keybl, Shane Babcock" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1286" ; a owl:Class ; rdfs:label "extraction duration time" ; rdfs:subClassOf obo:IAO_0000416 . obo:OBI_0003083 obo:IAO_0000111 "specimen collection time post disease onset" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen collection time measurement datum that is the measure of a time when specimens are collected after the onset of disease in a host." ; obo:IAO_0000117 "Chris Stoeckert, ORCID: 0000-0002-5714-991X" ; obo:IAO_0000119 "GROUP:FLU, Shane Babcock" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1286" ; a owl:Class ; rdfs:label "specimen collection time post disease onset" ; rdfs:subClassOf obo:OBI_0001619 . obo:OBI_0003084 obo:IAO_0000111 "specimen collection time post infection" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen collection time measurement datum that is the measure of a time when specimens are collected after an infection starts." ; obo:IAO_0000117 "Chris Stoeckert, ORCID: 0000-0002-5714-991X" ; obo:IAO_0000119 "VEuPathDB, EUPATH:0000613" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1286" ; a owl:Class ; rdfs:label "specimen collection time post infection" ; rdfs:subClassOf obo:OBI_0001619 . obo:OBI_0003085 obo:IAO_0000111 "laboratory postal address" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A postal address used as a directive to deliver something to a laboratory." ; obo:IAO_0000117 "Chris Stoeckert, ORCID: 0000-0002-5714-991X" ; obo:IAO_0000118 "laboratory address" ; obo:IAO_0000119 "GROUP:FLU, Shane Babcock" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1286" ; a owl:Class ; rdfs:label "laboratory postal address" ; rdfs:subClassOf obo:IAO_0000422 . obo:OBI_0003086 obo:IAO_0000111 "laboratory-based population" ; obo:IAO_0000112 "Refers to whether the mosquitoes used in the analysis of insecticide resistance were collected from an established strain or any other population kept in a laboratory under controlled conditions. (per MIRO_30000033)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A population where the collection of individuals is located and maintained in a laboratory, research, or production facility." ; obo:IAO_0000117 "Chris Stoeckert, ORCID: 0000-0002-5714-991X" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1370" ; a owl:Class ; rdfs:label "laboratory-based population" ; rdfs:subClassOf obo:OBI_0000181 . obo:OBI_0003087 obo:IAO_0000111 "autofluorescence assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A fluorescence detection assay in which the light that is naturally emitted by a sample is visualized after excitation of the sample with light at a suitable wavelength." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "intrinsic fluorescence assay" ; obo:IAO_0000119 "PMID:25578980", "url:https://en.wikipedia.org/wiki/Autofluorescence" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1393" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "autofluorescence assay" ; rdfs:subClassOf obo:OBI_0001501 . obo:OBI_0003088 obo:IAO_0000111 "autofluorescence microscopy assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An autofluorescence assay in which the light that is naturally emitted by a sample is visualized via microscopy after excitation of the sample with light at a suitable wavelength." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "PMID:25578980", "url:https://en.wikipedia.org/wiki/Autofluorescence" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1394" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "autofluorescence microscopy assay" ; rdfs:subClassOf obo:OBI_0003087, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400169 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400169 ] ) ] . obo:OBI_0003089 obo:IAO_0000111 "bulk assay for transposase-accessible chromatin using sequencing" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay for transposase-accessible chromatin using sequencing in which the sample that is sequenced is derived from a collection of cells, such as a tissue sample or entire cell culture, and therefore provides results representative of the aggregate of sample cells." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "bulk ATAC-seq" ; obo:IAO_0000119 "PMID:24097267" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1395" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "bulk assay for transposase-accessible chromatin using sequencing" ; rdfs:subClassOf obo:OBI_0002039 . obo:OBI_0003090 obo:IAO_0000111 "bulk RNA-seq assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An RNA-seq assay in which the sample that is sequenced is derived from a collection of cells, such as a tissue sample or entire cell culture, and therefore provides results representative of the aggregate of sample cells." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "url:https://www.biostars.org/p/458516/" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1396" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "bulk RNA-seq assay" ; rdfs:subClassOf obo:OBI_0001271 . obo:OBI_0003091 obo:IAO_0000111 "multiplexed fluorescent antibody imaging assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An imaging assay in which multiple cycles consisting of fluorescent labeling, imaging, and fluorophor deactivation are used to detect multiple proteins and their locations in a given sample of tissues or cells." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "PMID:29993362" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1397" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "multiplexed fluorescent antibody imaging assay" ; rdfs:subClassOf obo:OBI_0000185, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001501 obo:OBI_0003368 ) ] ] . obo:OBI_0003092 obo:IAO_0000111 "Cell DIVE multiplexed imaging assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A multiplexed fluorescent antibody imaging assay that involves an iterative staining, imaging and dye inactivation workflow for over 60 biomarkers on a single fixed tissue section." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "url:https://cancerres.aacrjournals.org/content/80/16_Supplement/1448", "url:https://www.cytivalifesciences.co.kr/wp-content/uploads/2020/07/Cell-DIVE-Tech-Info-Sheet-CY11898-09Apr20-DF.pdf" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1398" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "Cell DIVE multiplexed imaging assay" ; rdfs:subClassOf obo:OBI_0003091 . obo:OBI_0003093 obo:IAO_0000111 "co-detection by indexing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A multiplexed fluorescent antibody imaging assay that involves a highly multiplexed analysis of up to 40 proteins in a tissue using cyclic detection of DNA-indexed antibody panels." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "CODEX" ; obo:IAO_0000119 "url:https://www.scilifelab.se/facilities/co-detection-by-indexing-codex/" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1399" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "co-detection by indexing assay" ; rdfs:subClassOf obo:OBI_0003091 . obo:OBI_0003094 obo:IAO_0000111 "fluorescence in-situ hybridization assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in-situ hybridization assay in which fluorescently labeled molecules are used to localize specific DNA or RNA sequences." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "FISH" ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Fluorescence_in_situ_hybridization" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1400" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "fluorescence in-situ hybridization assay" ; rdfs:subClassOf obo:OBI_0001686, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001501 obo:OBI_0003368 ) ] ] . obo:OBI_0003095 obo:IAO_0000111 "decoding amplified targeted transcripts with fluorescence in situ hybridization assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A fluorescence in-situ hybridization assay which involves multiplex in situ digital quantification of targeted RNA transcripts in fresh or frozen tissue providing an understanding of the spatial organization of different cell types." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "DARTFISH" ; obo:IAO_0000119 "url:http://genome-tech.ucsd.edu/ZhangLab/index.php/data/tech-dev/", "url:http://www.weizmann.ac.il/conferences/SCG2015/sites/conferences.SCG2015/files/scg_2015_abstractbook_online_version.pdf", "url:https://escholarship.org/uc/item/5bq3128f" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1401" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "decoding amplified targeted transcripts with fluorescence in situ hybridization assay" ; rdfs:subClassOf obo:OBI_0000424, obo:OBI_0003094, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000880 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000880 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33697 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33697 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33697 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0010467 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001331 ] . obo:OBI_0003096 obo:IAO_0000111 "imaging mass cytometry assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry time of flight assay in which molecules of interest on or in cells are imaged through a system in which samples are labeled with multiple different rare-earth tagged antibodies. The sample is then ablated with a laser and the labeled material is detected by cytometry time of flight mass spectrometry." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "IMC", "imaging CyTOF" ; obo:IAO_0000119 "PMID:31798587" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1403" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "imaging mass cytometry assay" ; rdfs:subClassOf obo:OBI_0002115 . obo:OBI_0003097 obo:IAO_0000111 "liquid chromatography mass spectrometry assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A mass spectrometry assay where a sample mixture is first separated by liquid chromatography before being converted into ions which are characterized by using mass spectrometry based on their mass-to-charge ratio and relative abundance." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "LC-MS" ; obo:IAO_0000119 "CHMO:0000524" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1404" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "liquid chromatography mass spectrometry assay" ; rdfs:subClassOf obo:OBI_0000470 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000470 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003547 ] ) ] . obo:OBI_0003098 obo:IAO_0000111 "lightsheet fluorescence microscopy assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A fluorescence microscopy that involves capturing of photons emitted by fluorophores excited with a thin sheet of laser light in a sample only in a relatively narrow plane by a detection objective oriented perpendicularly to the light sheet and imaged onto a detection device such as a CCD camera." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "url:https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/light-sheet-fluorescence-microscopy" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1405" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "lightsheet fluorescence microscopy assay" ; rdfs:subClassOf obo:CHMO_0000087 . obo:OBI_0003099 obo:IAO_0000111 "matrix assisted laser desorption ionization imaging mass spectrometry assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A mass spectrometry assay that involves collection of spatially resolved mass spectra of a sample during microscopy where a pulse laser is used to produce both ionisation and vaporization. The sample is held in a matrix (such as dihydrobenzoic acid) to protect it from direct laser illumination and to separate the sample molecules. The spectra are used to visualise the spatial distribution of biomolecules by their molecular masses." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "MALDI-IMS" ; obo:IAO_0000119 "url:http://purl.obolibrary.org/obo/CHMO_0000054" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1406" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "matrix assisted laser desorption ionization imaging mass spectrometry assay" ; rdfs:subClassOf obo:OBI_0000470 . obo:OBI_0003100 obo:IAO_0000111 "multiplexed ion beam imaging assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry time of flight assay in which molecules of interest on or in cells are imaged through a system in which samples are labeled with multiple different rare-earth tagged antibodies. A primary ion beam is ued to rasterize sections under vacuum, releasing showers of secondary ions detected by cytometry time of flight mass spectrometry." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "MIBI" ; obo:IAO_0000119 "url:https://www.nature.com/articles/s41374-020-0417-4" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1407" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "multiplexed ion beam imaging assay" ; rdfs:subClassOf obo:OBI_0002115 . obo:OBI_0003101 obo:IAO_0000111 "nanospray desorption electrospray ionization assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A mass spectrometry assay that analyzes organic and biological molecules on a substrate by desorption of an analyte into a solvent bridge formed between two capillaries and the analysis surface. One capillary supplies solvent to create and maintain the bridge, while the second capillary transports the dissolved analyte from the bridge to the mass spectrometer. A high voltage applied between the inlet of mass spectrometer and the primary capillary creates a self-aspirating nanospray." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "NanoDESI" ; obo:IAO_0000119 "url:https://pubmed.ncbi.nlm.nih.gov/20593081/" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1408" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "nanospray desorption electrospray ionization assay" ; rdfs:subClassOf obo:OBI_0000470 . obo:OBI_0003102 obo:IAO_0000111 "nanodroplet processing in one pot for trace samples assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A protein expression profiling assay in which proteomics sample processing is performed in nanoliter volumes. Flow cytometry or laser microdissection is employed to isolate a small population or single cells into a nanoPOTS chip. Then, liquid chromatography mass spectrometry is used to measure the global protein expression." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "NanoPOTS" ; obo:IAO_0000119 "url:https://www.emsl.pnnl.gov/science/related-instrument/nanodroplet-processing-in-one-pot-for-trace-samples--nanopots-/1806" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1409" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "nanodroplet processing in one pot for trace samples assay" ; rdfs:subClassOf obo:OBI_0000615, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0003097 obo:OBI_0003368 ) ] ] . obo:OBI_0003103 obo:IAO_0000111 "periodic acid-Schiff staining assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A histological assay which is used on tissue samples to demonstrate the presence of carbohydrates and carbohydrate compounds such as polysaccharides, mucin, glycogen, or fungal cell wall components." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "PAS staining" ; obo:IAO_0000119 "url:https://microbenotes.com/periodic-acid-schiff-pas-staining/" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1410" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "periodic acid-Schiff staining assay" ; rdfs:subClassOf obo:OBI_0600020 . obo:OBI_0003104 obo:IAO_0000111 "single cell combinatorial indexing assay for transposase-accessessable chromatin using sequencing" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay for transposase-accessible chromatin that uses sequencing which involves single cell combinatorial indexing ('sci-') strategy where nucleic acids from each of many cells are uniquely tagged through several rounds of split-pool barcoding which enables identification of single cells without single cell isolation." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "sciATACseq" ; obo:IAO_0000119 "url:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158300/" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1411" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "single cell combinatorial indexing assay for transposase-accessessable chromatin using sequencing" ; rdfs:subClassOf obo:OBI_0002039 . obo:OBI_0003105 obo:IAO_0000111 "single-cell combinatorial indexing RNA sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A single-cell RNA sequencing assay that involves single cell combinatorial indexing ('sci-') strategy to profile the transcriptomes of single cells or nuclei without single cell isolation." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "sciRNAseq" ; obo:IAO_0000119 "url:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894354/" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1412" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "single-cell combinatorial indexing RNA sequencing assay" ; rdfs:subClassOf obo:OBI_0002631 . obo:OBI_0003106 obo:IAO_0000111 "sequential fluorescence in-situ hybridization assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A fluorescence in-situ hybridization assay that involves ultra-resolution imaging of cell activity by targetting thousands of single molecules with fluorescent probes which find and hybridize with complementary DNA or RNA sequences in the tissue sample, thus enabling identification of those molecules directly in single cells with their spatial context preserved." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "seqFISH" ; obo:IAO_0000119 "url:https://spatial.caltech.edu/seqfish/" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1413" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "sequential fluorescence in-situ hybridization assay" ; rdfs:subClassOf obo:OBI_0003094 . obo:OBI_0003107 obo:IAO_0000111 "slide-seq assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An RNA-seq assay that involves transfer of RNA from tissue sections onto a surface covered in DNA-barcoded beads with known positions, allowing the locations of the RNA to be inferred by sequencing." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000119 "url:https://science.sciencemag.org/content/363/6434/1463" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1414" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "slide-seq assay" ; rdfs:subClassOf obo:OBI_0001271 . obo:OBI_0003108 obo:IAO_0000111 "single-nucleus chromatin accessibility and mRNA expression sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A single-nucleus RNA sequencing assay that involves joint profiling of accessible chromatin and RNA within the same cells which enables direct matching of transcriptional regulation to its outputs." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "SNARE-seq", "SNAREseq" ; obo:IAO_0000119 "url:https://www.nature.com/articles/s41587-019-0290-0" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1416" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "single-nucleus chromatin accessibility and mRNA expression sequencing assay" ; rdfs:subClassOf obo:OBI_0003109 . obo:OBI_0003109 obo:IAO_0000111 "single-nucleus RNA sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A RNA-seq assay that is used for profiling gene expression in individual nuclei with optimized next generation sequencing (NGS) technologies. This allows the RNA-seq profiling of cell types that are more vulnerable to the tissue dissociation process, and that are therefore underrepresented in the final data set in single cell sequencing." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "sNuc-seq", "single nuclei RNA sequencing", "snRNA-seq" ; obo:IAO_0000119 "EFO:0009809", "url:https://www.biocompare.com/Editorial-Articles/557506-Advantages-of-Single-Nucleus-RNA-Sequencing/" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1415" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "single-nucleus RNA sequencing assay" ; rdfs:subClassOf obo:OBI_0001271 . obo:OBI_0003110 obo:IAO_0000111 "gas chromatography mass spectrometry assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A mass spectrometry assay combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determination of compounds." ; obo:IAO_0000117 "Michelle Giglio", "Rebecca Jackson", "Suvarna Nadendla" ; obo:IAO_0000118 "GC-MS" ; obo:IAO_0000119 "url:http://purl.bioontology.org/ontology/MESH/D008401" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1417" ; obo:IAO_0000234 "CFDE" ; a owl:Class ; rdfs:label "gas chromatography mass spectrometry assay" ; rdfs:subClassOf obo:OBI_0000470 . obo:OBI_0003111 obo:IAO_0000111 "SOMAscan assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that uses aptamers to detect protein analytes in serum." ; obo:IAO_0000117 "Bjoern Peters", "Randi Vita" ; obo:IAO_0000119 "Rohloff JC, et al. Nucleic acid ligands with protein-like side chains: modified aptamers and their uses as diagnostic and therapeutic agents. Mol Ther Nucleic Acids. 2014;3:e201." ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1308" ; obo:IAO_0000234 "ImmPort" ; a owl:Class ; rdfs:label "SOMAscan assay" ; rdfs:subClassOf obo:OBI_0000443 . obo:OBI_0003112 obo:IAO_0000111 "Olink assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A proximity extension assay that uses quantitative polymerase chain reaction (qPCR) technology to determine the concentration/presence of proteins using a high-multiplex, high-throughput protein biomarker platform. The assay utilizes two distinct oligonucleotide-labeled antibodies (‘probes’) that bind at different sites for each detected protein. When the two probes are in close proximity, a new PCR target sequence is formed by a proximity-dependent DNA polymerization event. The resulting sequence is subsequently detected and quantified using standard real-time PCR." ; obo:IAO_0000117 "Bjoern Peters", "Hector Guzman-Orozco", "Randi Vita" ; obo:IAO_0000119 "https://www.olink.com/" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1308" ; obo:IAO_0000234 "ImmPort" ; a owl:Class ; rdfs:label "Olink assay" ; rdfs:subClassOf obo:OBI_0003113 . obo:OBI_0003113 obo:IAO_0000111 "proximity extension assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that uses quantitative polymerase chain reaction (qPCR) technology to determine the concentration/presence of an analyte or analyte complex." ; obo:IAO_0000117 "Bjoern Peters", "Hector Guzman-Orozco", "Randi Vita" ; obo:IAO_0000119 "Bjoern Peters" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1308" ; obo:IAO_0000234 "ImmPort" ; a owl:Class ; rdfs:label "proximity extension assay" ; rdfs:subClassOf obo:OBI_0000443, obo:OBI_0002692, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002692 obo:OBI_0003368 ) ] ] . obo:OBI_0003114 obo:IAO_0000111 "Illumina MiniSeq" ; obo:IAO_0000112 "Whole genome sequencing of Klebsiella pneumoniae ST11 was performed using an Illumina Miniseq Sequencing System. PMID:31493526" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A small benchtop DNA sequencer which is manufactured by the Illumina corporation with integrated cluster generation, sequencing and data analysis. The sequencer accommodates various flow cell configurations and can produce up to 25M single reads or 50M paired-end reads per run." ; obo:IAO_0000117 "PERSON: Bonita Lam" ; obo:IAO_0000118 "MiniSeq" ; obo:IAO_0000119 "url:https://www.illumina.com/systems/sequencing-platforms/miniseq.html" ; a owl:Class ; rdfs:label "Illumina MiniSeq" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000759 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003115 obo:IAO_0000111 "antigen detection by cytometric bead array assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay in which a series of beads are coated with antibodies specific to antigens of interest. Antigens of interest attach to antibodies on the beads. Fluorescent labeled secondary antibodies are used to detect the antigens of interest." ; obo:IAO_0000117 "CMI-PB" ; obo:IAO_0000119 "CMI-PB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1399" ; a owl:Class ; rdfs:label "antigen detection by cytometric bead array assay" ; rdfs:subClassOf obo:OBI_0000920, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_1110034 ] ] . obo:OBI_0003116 obo:IAO_0000111 "antibody detection by cytometric bead array assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects antigen-specific antibodies. In the assay a series of beads are coated with antigens which capture antibodies specific to the antigens. Fluorescent labeled secondary antibodies are used to detect the antibodies of interest." ; obo:IAO_0000117 "CMI-PB" ; obo:IAO_0000119 "CMI-PB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1399" ; a owl:Class ; rdfs:label "antibody detection by cytometric bead array assay" ; rdfs:subClassOf obo:OBI_0000920, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0019814 ] ] . obo:OBI_0003117 obo:IAO_0000111 "3D molecular structure determination assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that determines the 3-dimensional configuration of a molecular entity or molecular complex." ; obo:IAO_0000117 "Bjoern Peters", "Hector Guzman-Orozco" ; obo:IAO_0000119 "IEDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1380" ; a owl:Class ; rdfs:label "3D molecular structure determination assay" ; rdfs:subClassOf obo:OBI_0600045 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600045 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001155 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:CHEBI_23367 obo:COB_0000080 ) ] ] ] ) ] . obo:OBI_0003118 obo:IAO_0000111 "electron-microscopy 3D molecular structure determination assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A 3D molecular structure determination assay that uses electron microscopy imaging." ; obo:IAO_0000117 "Bjoern Peters", "Hector Guzman-Orozco" ; obo:IAO_0000119 "IEDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1380" ; a owl:Class ; rdfs:label "electron-microscopy 3D molecular structure determination assay" ; rdfs:subClassOf obo:OBI_0003117, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000990 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000990 ] ) ] . obo:OBI_0003119 obo:IAO_0000111 "antigen:antibody complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A complex of molecular entitites which is the result of an antibody binding to an antigen." ; obo:IAO_0000117 "Bjoern Peters", "Hector Guzman-Orozco" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "antigen:antibody complex" ; rdfs:subClassOf obo:COB_0000080, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 obo:OBI_1110034 ) ] ] . obo:OBI_0003120 obo:IAO_0000111 "epitope:MHC:TCR complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A complex of molecular entities which is the result of a T cell receptor binding to a MHC-epitope complex." ; obo:IAO_0000117 "Bjorne Peters", "Hector Guzman-Orozco" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "epitope:MHC:TCR complex" ; rdfs:subClassOf obo:COB_0000080, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042101 obo:OBI_0003121 ) ] ] . obo:OBI_0003121 obo:IAO_0000111 "MHC:ligand complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A complex of molecular entities which is the result of a MHC molecule binding with a ligand." ; obo:IAO_0000117 "Bjorne Peters", "Hector Guzman-Orozco" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "MHC:ligand complex" ; rdfs:subClassOf obo:COB_0000080, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042611 ] . obo:OBI_0003122 obo:IAO_0000111 "3D cell structure determination assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A 3D structure determination assay that determines the 3-dimensional configuration of a cell." ; obo:IAO_0000117 "Hector Guzman-Orozco", "Patrick Ray" ; obo:IAO_0000119 "Hector Guzman-Orozco", "Patrick Ray" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1364" ; a owl:Class ; rdfs:label "3D cell structure determination assay" ; rdfs:subClassOf obo:OBI_0001977, obo:OBI_0600045 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600045 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:CL_0000000 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001155 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000000 ] ] ) ] . obo:OBI_0003123 obo:IAO_0000111 "3D neural cell structure determination assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A 3D cell structure determination assay that determines the 3-dimensional configuration of a neural cell." ; obo:IAO_0000117 "Hector Guzman-Orozco", "Patrick Ray" ; obo:IAO_0000119 "Hector Guzman-Orozco", "Patrick Ray" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1364" ; obo:IAO_0000234 "Allen Institute for Brain Science" ; a owl:Class ; rdfs:label "3D neural cell structure determination assay" ; rdfs:subClassOf obo:OBI_0003122 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003122 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001155 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0002319 ] ] ) ] . obo:OBI_0003124 obo:IAO_0000111 "neuron morphology assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A 3D neural cell structure determination assay that determines the 3-dimensional configuration of a neuron." ; obo:IAO_0000117 "Hector Guzman-Orozco", "Patrick Ray" ; obo:IAO_0000119 "Patrick Ray" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1364" ; obo:IAO_0000234 "Allen Institute for Brain Science" ; a owl:Class ; rdfs:label "neuron morphology assay" ; rdfs:subClassOf obo:OBI_0003123, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001155 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000540 ] ] . obo:OBI_0003125 obo:IAO_0000111 "mosaicism with repeat frameshift genetic sparse labeling" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A 3D neural cell structure determination assay where sparse and stochastic methods are used to label genetically-defined neurons." ; obo:IAO_0000117 "Patrick Ray" ; obo:IAO_0000118 "MORF genetic sparse labeling" ; obo:IAO_0000119 "https://biccn.org/teams/u01-yang", "https://doi.org/10.1016/j.neuron.2020.07.019" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1364" ; obo:IAO_0000234 "Allen Institute for Brain Science" ; a owl:Class ; rdfs:label "mosaicism with repeat frameshift genetic sparse labeling" ; rdfs:subClassOf obo:OBI_0003123, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001155 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0002319 ] ] . obo:OBI_0003126 obo:IAO_0000111 "neuron morphology reconstruction assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A neuron morphology assay where the morphology or structure of a neuron is represented. Often, this assay is a combination of different assays (sparse labelling, fluorescent labeling, fMOST)." ; obo:IAO_0000116 "The representation of the morphology (3D structure) of a neuron can be a summary of various measurements relating to the dimensions of the neuron in question." ; obo:IAO_0000117 "Hector Guzman-Orozco", "Patrick Ray" ; obo:IAO_0000119 "http://doi.org/10.1101/675280" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1364" ; obo:IAO_0000234 "Allen Institute for Brain Science" ; a owl:Class ; rdfs:label "neuron morphology reconstruction assay" ; rdfs:subClassOf obo:OBI_0003124 . obo:OBI_0003127 obo:IAO_0000111 "B cell epitope assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An immune epitope assay that characterizes the structrue of an antibody-epitope complex, or measures the binding of an antibody receptor to epitope, or the immune response process resulting from such a binding event or the recognition of the epitope." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "B cell assay|any method" ; a owl:Class ; rdfs:label "B cell epitope assay" ; rdfs:subClassOf obo:OBI_1110128 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0001702 obo:OBI_0003119 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ) ] ] ] ) ] . obo:OBI_0003128 obo:IAO_0000111 "T cell epitope assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An immune epitope assay that characterizes the structrue of an epitope-T cell receptor complex, or measures the binding of a T cell receptor to epitope, or the immune response process resulting from such a binding event or the recognition of the epitope." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "T cell assay|any method" ; a owl:Class ; rdfs:label "T cell epitope assay" ; rdfs:subClassOf obo:OBI_1110128 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0003120 obo:OBI_1110057 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0003129 obo:IAO_0000111 "chemical mutagenesis" ; obo:IAO_0000112 "129/Sv male mice were injected with ENU and mated to C57BL/6 females. Their first-generation (G1) male progeny were again crossed to C57BL/6 females, and then backcrossed to one of their second-generation (G2) daughters to yield a third-generation (G3). PMID:18802465" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A form of random mutagenesis that produces a mutation by introducing the organism to a chemical mutagen." ; obo:IAO_0000116 "Equivalent to FlyBase \"chemical\" (FBcv:0000525) in the origin of mutation branch and Dd mutagenesis meth0d term chemical mutagenesis (DDMUMET:0000014)." ; obo:IAO_0000117 "Susan Bello ORCID:orcid.org/0000-0003-4606-0597" ; obo:IAO_0000119 "url:https://pubmed.ncbi.nlm.nih.gov/25646611/" ; a owl:Class ; rdfs:label "chemical mutagenesis" ; rdfs:subClassOf obo:OBI_0002620 . obo:OBI_0003130 obo:IAO_0000111 "irradiation mutagenesis" ; obo:IAO_0000112 "Groups of (101 x C3H)F1 hybrid male mice 11 weeks old were exposed to two different doses of 137Cs gamma rays. PMID:7035547" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A form of random mutagenesis that produces a random mutation by exposing the organism to radiation." ; obo:IAO_0000116 "Equivalent to FlyBase \"irradiation\" (FBcv:0000503) in the origin of mutation branch." ; obo:IAO_0000117 "Susan Bello ORCID:orcid.org/0000-0003-4606-0597" ; obo:IAO_0000118 "radiation induced mutagenesis" ; obo:IAO_0000119 "url:http://purl.obolibrary.org/obo/FBcv_0000503" ; a owl:Class ; rdfs:label "irradiation mutagenesis" ; rdfs:subClassOf obo:OBI_0002620 . obo:OBI_0003131 obo:IAO_0000111 "directed mutagenesis" ; obo:IAO_0000112 "Exons 20 and 21 were targeted for deletion because they encode the signature and Walker B motifs of the first ATP-binding domain, elements that are known to be critical for ABCA1 function. PMID:15550377" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An induced mutation in which a specific gene(s) or part of a gene(s) is altered." ; obo:IAO_0000117 "Susan Bello ORCID:orcid.org/0000-0003-4606-0597" ; obo:IAO_0000119 "url:https://www.ncbi.nlm.nih.gov/books/NBK21878/def-item/A4754/" ; a owl:Class ; rdfs:label "directed mutagenesis" ; rdfs:subClassOf obo:OBI_0001154 . obo:OBI_0003132 obo:IAO_0000111 "endonuclease mediated mutagenesis" ; obo:IAO_0000112 "We have generated a WMS mouse model with S236X mutation in ADAMTS10 which is similar to the R237X mutation identifiedin WMS patients using CRISPR-Cas9. PMID:30060141" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A directed mutagenesis in which guide RNAs and an endonuclease (cas9, TALEN) are used to introduce a mutation at a specific location in a gene." ; obo:IAO_0000116 "Equivalent to FlyBase term \"site specific cleavage\" (FBcv:0003007) in the origin of mutation branch." ; obo:IAO_0000117 "Susan Bello ORCID:orcid.org/0000-0003-4606-0597" ; obo:IAO_0000119 "url:https://pubmed.ncbi.nlm.nih.gov/28177771/" ; a owl:Class ; rdfs:label "endonuclease mediated mutagenesis" ; rdfs:subClassOf obo:OBI_0003131 . obo:OBI_0003133 obo:IAO_0000111 "cas mediated mutagenesis" ; obo:IAO_0000112 "Briefly, to create Adar1 M249A/M249A mice, guide RNA targeting 5’-ACCTTCTGAGCCTCTTGACA-3’ was synthesized by using Gene Art Precisiong RNA Synthesis Kit (ThermoFisherScientific). Pronuclear-stage mouse embryos (CLEA Japan Inc., Tokyo, Japan) were electroporated to introduce Cas9 mRNA, the guide RNA and a single-stranded donor... PMID:33983932" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An endonuclease mediated mutagenesis in which guide RNAs and cas are used to introduce a mutation at a specific location in the genome." ; obo:IAO_0000116 "Equivalent (narrow match) to FlyBase term \"CRISPR/Cas9\" (FBcv:0003008, narrow match as the OBI term covers all forms of cas) in the origin of mutation branch and Dd mutagenesis method term \"CRISPR/Cas9\" (DDMUMET:0000025)." ; obo:IAO_0000117 "Susan Bello ORCID:orcid.org/0000-0003-4606-0597" ; obo:IAO_0000118 "CRISPR mediated mutagenesis", "CRISPR/cas mediated mutagenesis" ; obo:IAO_0000119 "url:https://pubmed.ncbi.nlm.nih.gov/28177771/" ; a owl:Class ; rdfs:label "cas mediated mutagenesis" ; rdfs:subClassOf obo:OBI_0003132 . obo:OBI_0003134 obo:IAO_0000111 "TALEN mediated mutagenesis" ; obo:IAO_0000112 "We designed transcription activator-like effector nucleases (TALENs) and a single-stranded oligo (ssOligo) donor template to edit the endogenous Actb locus within the mouse genome. PMID:30012594" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An endonuclease mediated mutagenesis in which guide RNAs and transcription activator-like effector nucleases (TALENs) are used to introduce a mutation at a specific location in the genome." ; obo:IAO_0000116 "Equivalent to FlyBase term \"TALEN\" (FBcv:0003009) in the origin of mutation branch." ; obo:IAO_0000117 "Susan Bello ORCID:orcid.org/0000-0003-4606-0597" ; obo:IAO_0000119 "url:https://pubmed.ncbi.nlm.nih.gov/23664777/" ; a owl:Class ; rdfs:label "TALEN mediated mutagenesis" ; rdfs:subClassOf obo:OBI_0003132 . obo:OBI_0003135 obo:IAO_0000111 "zinc finger mediated mutagenesis" ; obo:IAO_0000112 "ZFN constructs targeting the third exon of the mouse Apoc2 gene were designed and synthetized by Sigma Aldrich... PMID:26574515" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An endonuclease mediated mutagenesis in which synthetic zinc-finger proteins designed to target specific DNA sequences are used to introduce a mutation at a specific location in the genome." ; obo:IAO_0000116 "Equivalent to FlyBase term \"ZFN\" (FBcv:0003239) in the origin of mutation branch." ; obo:IAO_0000117 "Susan Bello ORCID:orcid.org/0000-0003-4606-0597" ; obo:IAO_0000118 "ZFN mediated mutagenesis" ; obo:IAO_0000119 "url:https://pubmed.ncbi.nlm.nih.gov/23664777/" ; a owl:Class ; rdfs:label "zinc finger mediated mutagenesis" ; rdfs:subClassOf obo:OBI_0003132 . obo:OBI_0003136 obo:IAO_0000111 "transgenic mutagenesis" ; obo:IAO_0000112 "Transgenic mice were then generated by pronuclear injection of either the mixed MoPrP-PS1 and MoPrP-APP or the bicistronic MoPrP–APP/IRES/PS1 expression cassettes into single cell embryos derived from F2 hybrids of C57BL/6J and C3H/HeJ mice... PMID:11337275" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A form of random mutagenesis that produces a mutation by introducing a construct into the genome of an organism in a random or semi-random fashion." ; obo:IAO_0000117 "Susan Bello ORCID:orcid.org/0000-0003-4606-0597" ; obo:IAO_0000119 "url:https://pubmed.ncbi.nlm.nih.gov/23996268/" ; a owl:Class ; rdfs:label "transgenic mutagenesis" ; rdfs:subClassOf obo:OBI_0002620 . obo:OBI_0003137 obo:IAO_0000111 "gene-trap mutagenesis" ; obo:IAO_0000112 "Constructs lacking a promoter and including a B3-galactosidase gene, or a reporter gene encoding a protein with both B3-galactosidase and neomycin phosphotransferase activity, were designed so that activation of the reporter gene depends on its insertion within an active transcription unit. PMID:1653172" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A transgenic mutagenesis that produces a mutation by introducing a construct designed to capture the expression of an endogenous gene by creating a spliced fusion transcript when inserted into the genome of an organism." ; obo:IAO_0000117 "Susan Bello ORCID:orcid.org/0000-0003-4606-0597" ; obo:IAO_0000119 "url:https://pubmed.ncbi.nlm.nih.gov/17877761/" ; a owl:Class ; rdfs:label "gene-trap mutagenesis" ; rdfs:subClassOf obo:OBI_0003136 . obo:OBI_0003138 obo:IAO_0000111 "enhancer-trap mutagenesis" ; obo:IAO_0000112 "We generated several lines of enhancer trap mice carrying an enhancer detector cassette expressing Cre recombinase under the transcriptional control of the minimal promoter (129 base pairs) of the mouse Thy-1.2 gene. PMID:22492032" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A transgenic mutagenesis that produces a mutation by introducing a construct designed to monitor transcriptionally active regions when inserted into the genome of an organism by inserting a reporter gene that requires cis-acting DNA sequences in the genome to activate reporter gene expression." ; obo:IAO_0000117 "Susan Bello ORCID:orcid.org/0000-0003-4606-0597" ; obo:IAO_0000119 "url:https://pubmed.ncbi.nlm.nih.gov/17877761/" ; a owl:Class ; rdfs:label "enhancer-trap mutagenesis" ; rdfs:subClassOf obo:OBI_0003136 . obo:OBI_0003139 obo:IAO_0000111 "targeted mutagenesis" ; obo:IAO_0000112 "To disrupt the mdr1a gene a 1.6 kb NheI genomic fragment containing exons 6 and 7 was replaced by a hygromycin phosphotransferase cassette in a targeting vector. PMID:7910522" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A directed mutation in which a construct is used to introduce a mutation into a specific genome location through homologous recombination." ; obo:IAO_0000116 "Equivalent to FlyBase term \"gene targeting by homologous recombination\" (FBcv:0000710) in the origin of mutation branch." ; obo:IAO_0000117 "Susan Bello ORCID:orcid.org/0000-0003-4606-0597" ; obo:IAO_0000118 "gene targeting by homologous recombination" ; obo:IAO_0000119 "url:https://pubmed.ncbi.nlm.nih.gov/23996268/" ; a owl:Class ; rdfs:label "targeted mutagenesis" ; rdfs:subClassOf obo:OBI_0003131 . obo:OBI_0003140 obo:IAO_0000111 "transposon-induced mutagenesis" ; obo:IAO_0000112 "In order to achieve SB transposon-mediated mutagenesis in mice, we employed the gene trap scheme using a novel transposon vector, and we have generated a large number of mutant mice, approximately 30% of which displayed the phenotype. PMID:16880528" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A random mutagenesis in which expression of a transposase causes the mobilization of an artificial or modified transposable element with the insertion of the element into the genome creating a mutation." ; obo:IAO_0000116 "Equivalent to FlyBase \"transposable element activity\" (FBcv:0000483) in the origin of mutation branch." ; obo:IAO_0000117 "Susan Bello ORCID:orcid.org/0000-0003-4606-0597" ; obo:IAO_0000119 "url:https://pubmed.ncbi.nlm.nih.gov/32050713/" ; a owl:Class ; rdfs:label "transposon-induced mutagenesis" ; rdfs:subClassOf obo:OBI_0002620 . obo:OBI_0003141 obo:IAO_0000111 "categorical binding datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A binding datum that is expressed as a categorical value." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000118 "qualitative binding datum" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "categorical binding datum" ; rdfs:subClassOf obo:OBI_0001181, [ a owl:Restriction ; owl:onProperty obo:OBI_0001938 ; owl:someValuesFrom obo:OBI_0001930 ] . obo:OBI_0003142 obo:IAO_0000111 "quantitative binding datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A binding datum that is expressed using numbers." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "quantitative binding datum" ; rdfs:subClassOf obo:OBI_0001181 . obo:OBI_0003143 obo:IAO_0000111 "EC50 binding datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A quantitative binding datum that is expressed as a half-maximal effective concentration (EC50)." ; obo:IAO_0000117 "Bjoern Peters", "Hector Guzman-Orozco" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "EC50 binding datum" ; rdfs:subClassOf obo:OBI_0001180, obo:OBI_0003142 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003142 [ a owl:Class ; owl:intersectionOf (obo:OBI_0001180 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001588 ] ) ] ) ] . obo:OBI_0003144 obo:IAO_0000111 "IC50 binding datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A quantitative binding datum that is expressed as a half-maximal inhibitory concentration (IC50)." ; obo:IAO_0000117 "Bjoern Peters", "Hector Guzman-Orozco" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "IC50 binding datum" ; rdfs:subClassOf obo:OBI_0001191, obo:OBI_0003142 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003142 [ a owl:Class ; owl:intersectionOf (obo:OBI_0001191 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001588 ] ) ] ) ] . obo:OBI_0003145 obo:IAO_0000111 "assay measuring quantitative binding of a MHC:ligand complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that detects the binding of a MHC molecule with a ligand, and produces a quantitative measurement of the binding as an output." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "quantitative binding|binding assay" ; a owl:Class ; rdfs:label "assay measuring quantitative binding of a MHC:ligand complex" ; rdfs:subClassOf obo:OBI_1110126 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0003142 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001503 ] ] ) ] . obo:OBI_0003146 obo:IAO_0000111 "assay measuring quantitative binding of an antigen:antibody complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that detects the binding of an antigen with an antibody, and produces a quantitative measurement of the binding as an output." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "quantitative binding|binding assay" ; a owl:Class ; rdfs:label "assay measuring quantitative binding of an antigen:antibody complex" ; rdfs:subClassOf obo:OBI_1110127 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0003142 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001702 ] ] ) ] . obo:OBI_0003147 obo:IAO_0000111 "assay measuring quantitative binding of an epitope:MHC:TCR complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that detects the binding of a MHC:epitope complex with a T cell receptor, and produces a quantitative measurement of the binding as an output." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "quantitative binding|binding assay" ; a owl:Class ; rdfs:label "assay measuring quantitative binding of an epitope:MHC:TCR complex" ; rdfs:subClassOf obo:OBI_1110037 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0003142 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_1110057 ] ] ) ] . obo:OBI_0003148 obo:IAO_0000111 "albumin concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An albumin assay that measures the concentration of albumin in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "albumin concentration assay" ; rdfs:subClassOf obo:OBI_2100022 . obo:OBI_0003149 obo:IAO_0000111 "basophil percentage assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A basophil assay that measures the percentage of basophils in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "basophil percentage assay" ; rdfs:subClassOf obo:OBI_0003021 . obo:OBI_0003150 obo:IAO_0000111 "calcium cation concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A calcium cation assay that measures the concentration of calcium cations in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "calcium cation concentration assay" ; rdfs:subClassOf obo:OBI_2100024 . obo:OBI_0003151 obo:IAO_0000111 "chloride concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A chloride assay that measures the concentration of chloride in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "chloride concentration assay" ; rdfs:subClassOf obo:OBI_2100010 . obo:OBI_0003152 obo:IAO_0000111 "cholesterol concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cholesterol assay that measures the concentration of cholesterol in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "cholesterol concentration assay" ; rdfs:subClassOf obo:OBI_2100031 . obo:OBI_0003153 obo:IAO_0000111 "creatinine concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A creatinine assay that measures the concentration of creatinine in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "creatinine concentration assay" ; rdfs:subClassOf obo:OBI_2100003 . obo:OBI_0003154 obo:IAO_0000111 "eosinophil percentage assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An eosinophil assay that measures the percentage of eosinophils in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "eosinophil percentage assay" ; rdfs:subClassOf obo:OBI_0003023 . obo:OBI_0003155 obo:IAO_0000111 "globulin concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A globulin assay that measures the concentration of globulin in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "globulin concentration assay" ; rdfs:subClassOf obo:OBI_0003015 . obo:OBI_0003156 obo:IAO_0000111 "hemoglobin concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A hemoglobin assay that measures the amount of hemoglobin in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "hemoglobin concentration assay" ; rdfs:subClassOf obo:OBI_2100014 . obo:OBI_0003157 obo:IAO_0000111 "high-density lipoprotein cholesterol concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A high-density lipoprotein cholesterol assay that measures the concentration of high-density lipoprotein cholesterol in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "high-density lipoprotein cholesterol concentration assay" ; rdfs:subClassOf obo:OBI_2100030 . obo:OBI_0003158 obo:IAO_0000111 "iron concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An iron assay that measures the concentration of iron cation in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "iron concentration assay" ; rdfs:subClassOf obo:OBI_0003011 . obo:OBI_0003159 obo:IAO_0000111 "low-density lipoprotein cholesterol concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A low-density lipoprotein cholesterol assay that measures the concentration of low-density lipoprotein cholesterol in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "low-density lipoprotein cholesterol concentration assay" ; rdfs:subClassOf obo:OBI_2100032 . obo:OBI_0003160 obo:IAO_0000111 "lymphocyte percentage assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A lymphocyte assay that measures the percentage of lymphocytes in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "lymphocyte percentage assay" ; rdfs:subClassOf obo:OBI_0003024 . obo:OBI_0003161 obo:IAO_0000111 "metamyelocyte count assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A metamyelocyte assay that measures the number of metamyelocytes in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "metamyelocyte count assay" ; rdfs:subClassOf obo:OBI_0003017 . obo:OBI_0003162 obo:IAO_0000111 "metamyelocyte percentage assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A metamyelocyte assay that measures the percentage of metamyelocytes in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "metamyelocyte percentage assay" ; rdfs:subClassOf obo:OBI_0003017 . obo:OBI_0003163 obo:IAO_0000111 "methemoglobin percentage assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A methemoglobin assay that measures the percentage of methemoglobin in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "methemoglobin percentage assay" ; rdfs:subClassOf obo:OBI_2100040 . obo:OBI_0003164 obo:IAO_0000111 "monocyte percentage assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A monocyte assay that measures the percentage of monocytes in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "monocyte percentage assay" ; rdfs:subClassOf obo:OBI_0003025 . obo:OBI_0003165 obo:IAO_0000111 "myelocyte count assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A myelocyte assay that measures the number of myelocytes in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "myelocyte count assay" ; rdfs:subClassOf obo:OBI_0003016 . obo:OBI_0003166 obo:IAO_0000111 "neutrophil percentage assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A neutrophil assay that measures the percentage of neutrophils in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "neutrophil percentage assay" ; rdfs:subClassOf obo:OBI_0003022 . obo:OBI_0003167 obo:IAO_0000111 "phosphate ion concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A phosphate ion assay that measures the concentration of phosphate ions in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "phosphate ion concentration assay" ; rdfs:subClassOf obo:OBI_2100015 . obo:OBI_0003168 obo:IAO_0000111 "potassium(1+) concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A potassium(1+) assay that measures the concentration of potassium(1+) in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "potassium(1+) concentration assay" ; rdfs:subClassOf obo:OBI_2100004 . obo:OBI_0003170 obo:IAO_0000111 "reticulocyte percentage assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A reticulocyte assay that measures the percentage of reticulocytes in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "reticulocyte percentage assay" ; rdfs:subClassOf obo:OBI_0003026 . obo:OBI_0003171 obo:IAO_0000111 "sodium(1+) concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A sodium(1+) assay that measures the concentration of sodium(1+) in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "sodium(1+) concentration assay" ; rdfs:subClassOf obo:OBI_2100002 . obo:OBI_0003172 obo:IAO_0000111 "thyroid stimulating hormone concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A thyroid stimulating hormone assay that measures the concentration of thyroid stimulating hormone in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "thyroid stimulating hormone concentration assay" ; rdfs:subClassOf obo:OBI_2100033 . obo:OBI_0003173 obo:IAO_0000111 "triglyceride concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A triglyceride assay that measures the concentration of triglycerides in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "triglyceride concentration assay" ; rdfs:subClassOf obo:OBI_2100029 . obo:OBI_0003174 obo:IAO_0000111 "3,3',5'-triiodothyronine concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A 3,3',5'-triiodothyronine assay that measures the concentration of 3,3',5'-triiodothyronine in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "3,3',5'-triiodothyronine concentration assay" ; rdfs:subClassOf obo:OBI_2100046 . obo:OBI_0003175 obo:IAO_0000111 "fibrinogen concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A fibrinogen assay that measures the concentration of fibrinogen in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "fibrinogen concentration assay" ; rdfs:subClassOf obo:OBI_0003010 . obo:OBI_0003176 obo:IAO_0000111 "free thyroxine concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A thyroxine assay that measures the concentration of free thyroxine in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "free thyroxine concentration assay" ; rdfs:subClassOf obo:OBI_2100035 . obo:OBI_0003177 obo:IAO_0000111 "total thyroxine concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A thyroxine assay that measures the concentration of total thyroxine in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "total thyroxine concentration assay" ; rdfs:subClassOf obo:OBI_2100035 . obo:OBI_0003180 obo:IAO_0000111 "direct bilirubin concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A bilirubin IXalpha assay that measures the concentration of direct bilirubin in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "direct bilirubin concentration assay" ; rdfs:subClassOf obo:OBI_2100018 . obo:OBI_0003181 obo:IAO_0000111 "indirect bilirubin concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A bilirubin IXalpha assay that measures the concentration of indirect bilirubin in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "indirect bilirubin concentration assay" ; rdfs:subClassOf obo:OBI_2100018 . obo:OBI_0003182 obo:IAO_0000111 "total bilirubin concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A bilirubin IXalpha assay that measures the concentration of total bilirubin in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "total bilirubin concentration assay" ; rdfs:subClassOf obo:OBI_2100018 . obo:OBI_0003183 obo:IAO_0000111 "mean cell hemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A hemoglobin assay that measures the average concentration of hemoglobin in a population of erythrocytes." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "mean cell hemoglobin assay" ; rdfs:subClassOf obo:OBI_2100014 . obo:OBI_0003184 obo:IAO_0000111 "mean cell hemoglobin concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A hemoglobin assay that measures the concentration of hemoglobin in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "mean cell hemoglobin concentration assay" ; rdfs:subClassOf obo:OBI_2100014 . obo:OBI_0003185 obo:IAO_0000111 "mean platelet volume assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A platelet assay that measures the average volume of platelets in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "mean platelet volume assay" ; rdfs:subClassOf obo:OBI_0003028 . obo:OBI_0003186 obo:IAO_0000111 "immature neutrophil count assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A neutrophil assay that measures the number of immature neutrophils in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "immature neutrophil count assay" ; rdfs:subClassOf obo:OBI_0003022, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000776 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CL_0000776 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000776 ] ] . obo:OBI_0003187 obo:IAO_0000111 "immature neutrophil percentage assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An neutrophil assay that measures the percentage of immature neutrophils in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "immature neutrophil percentage assay" ; rdfs:subClassOf obo:OBI_0003022, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000776 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CL_0000776 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000776 ] ] . obo:OBI_0003188 obo:IAO_0000111 "nucleated erythrocyte percentage assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An erythrocyte assay that measures the percentage of nucleated erythrocytes in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "nucleated erythrocyte percentage assay" ; rdfs:subClassOf obo:OBI_0003190, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000562 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CL_0000562 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000562 ] ] . obo:OBI_0003189 obo:IAO_0000111 "mean cell volume assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An erythrocyte assay that measures the average volume of erythrocytes in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "mean cell volume assay" ; rdfs:subClassOf obo:OBI_0003190 . obo:OBI_0003190 obo:IAO_0000111 "erythrocyte assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cytometry assay that measures the abundance and/or characteristics of erythrocytes." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "erythrocyte assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000232 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CL_0000232 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000232 ] ] . obo:OBI_0003191 obo:IAO_0000111 "manual hematocrit assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A hematocrit assay that measures the percentage of erythrocytes in a specimen by manual processes." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "manual hematocrit assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000232 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CL_0000232 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000232 ] ] . obo:OBI_0003192 obo:IAO_0000111 "adiponectin assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An analyte assay that measures the abundance of adiponectin" ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "adiponectin assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003777 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003777 ] ) ] . obo:OBI_0003193 obo:IAO_0000111 "adiponectin concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An adiponectin assay that measures the concentration of adiponectin in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "adiponectin concentration assay" ; rdfs:subClassOf obo:OBI_0003192, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003777 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003777 ] ) ] . obo:OBI_0003194 obo:IAO_0000111 "creatine assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatine" ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "creatine assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16919 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16919 ] ) ] . obo:OBI_0003195 obo:IAO_0000111 "creatine concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A creatine assay that measures the concentration of creatine in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "creatine concentration assay" ; rdfs:subClassOf obo:OBI_0003194, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16919 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16919 ] ) ] . obo:OBI_0003196 obo:IAO_0000111 "estradiol assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An analyte assay that measures the abundance of estradiol" ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "estradiol assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_23965 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_23965 ] ) ] . obo:OBI_0003197 obo:IAO_0000111 "estradiol concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An estradiol assay that measures the concentration of estradiol in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "estradiol concentration assay" ; rdfs:subClassOf obo:OBI_0003196, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_23965 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_23965 ] ) ] . obo:OBI_0003202 obo:IAO_0000111 "leptin assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An analyte assay that measures the abundance of leptin" ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "leptin assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000009758 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000009758 ] ) ] . obo:OBI_0003203 obo:IAO_0000111 "leptin concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An leptin assay that measures the concentration of leptin in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "leptin concentration assay" ; rdfs:subClassOf obo:OBI_0003202 . obo:OBI_0003204 obo:IAO_0000111 "lipoprotein concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An analyte assay that measures the abundance of lipoprotein" ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "lipoprotein concentration assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_6495 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_6495 ] ) ] . obo:OBI_0003205 obo:IAO_0000111 "high-density lipoprotein concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A lipoprotein concentration assay that measures the concentration of high-density lipoprotein in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "high-density lipoprotein concentration assay" ; rdfs:subClassOf obo:OBI_0003204, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39025 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39025 ] ) ] . obo:OBI_0003206 obo:IAO_0000111 "low-density lipoprotein concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A lipoprotein concentration assay that measures the concentration of low-density lipoprotein in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "low-density lipoprotein concentration assay" ; rdfs:subClassOf obo:OBI_0003204, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39026 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39026 ] ) ] . obo:OBI_0003207 obo:IAO_0000111 "very-low-density lipoprotein concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A lipoprotein concentration assay that measures the concentration of very-low-density lipoprotein in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "very-low-density lipoprotein concentration assay" ; rdfs:subClassOf obo:OBI_0003204, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39027 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39027 ] ) ] . obo:OBI_0003208 obo:IAO_0000111 "luteinizing hormone assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An analyte assay that measures the abundance of luteinizing hormone" ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "luteinizing hormone assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_81568 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_81568 ] ) ] . obo:OBI_0003209 obo:IAO_0000111 "luteinizing hormone concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A luteinizing hormone assay that measures the concentration of luteinizing hormone in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "luteinizing hormone concentration assay" ; rdfs:subClassOf obo:OBI_0003208 . obo:OBI_0003210 obo:IAO_0000111 "nitrite assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An analyte assay that measures the abundance of nitrite" ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "nitrite assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16301 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16301 ] ) ] . obo:OBI_0003211 obo:IAO_0000111 "nitrite concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A nitrite assay that measures the concentration of nitrite in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "nitrite concentration assay" ; rdfs:subClassOf obo:OBI_0003210 . obo:OBI_0003212 obo:IAO_0000111 "phospholipid assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An analyte assay that measures the abundance of phospholipid" ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "phospholipid assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16247 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16247 ] ) ] . obo:OBI_0003213 obo:IAO_0000111 "phospholipid concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A phospholipid assay that measures the concentration of phospholipids in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "phospholipid concentration assay" ; rdfs:subClassOf obo:OBI_0003212 . obo:OBI_0003214 obo:IAO_0000111 "progesterone assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An analyte assay that measures the abundance of progesterone" ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "progesterone assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17026 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17026 ] ) ] . obo:OBI_0003215 obo:IAO_0000111 "progesterone concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A progesterone assay that measures the concentration of progesterone in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "progesterone concentration assay" ; rdfs:subClassOf obo:OBI_0003214 . obo:OBI_0003216 obo:IAO_0000111 "testosterone assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An analyte assay that measures the abundance of testosterone" ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "testosterone assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17347 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17347 ] ) ] . obo:OBI_0003217 obo:IAO_0000111 "testosterone concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A testosterone assay that measures the concentration of testosterone in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "testosterone concentration assay" ; rdfs:subClassOf obo:OBI_0003216 . obo:OBI_0003218 obo:IAO_0000111 "bile salt assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bile salt" ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "bile salt assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_22868 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_22868 ] ) ] . obo:OBI_0003219 obo:IAO_0000111 "bile salt concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A bile salt assay that measures the concentration of bile salt in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "bile salt concentration assay" ; rdfs:subClassOf obo:OBI_0003218 . obo:OBI_0003220 obo:IAO_0000111 "fatty acid assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An analyte assay that measures the abundance of fatty acid" ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "fatty acid assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35366 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35366 ] ) ] . obo:OBI_0003221 obo:IAO_0000111 "free fatty acid concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A fatty acid assay that measures the concentration of free fatty acids in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "free fatty acid concentration assay" ; rdfs:subClassOf obo:OBI_0003220 . obo:OBI_0003222 obo:IAO_0000111 "insulin assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An analyte assay that measures the abundance of insulin" ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "insulin assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_145810 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_145810 ] ) ] . obo:OBI_0003223 obo:IAO_0000111 "insulin concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A insulin assay that measures the concentration of insulin in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "insulin concentration assay" ; rdfs:subClassOf obo:OBI_0003222 . obo:OBI_0003224 obo:IAO_0000111 "follicle stimulating hormone assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An analyte assay that measures the abundance of follicle stimulating hormone" ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "follicle stimulating hormone assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_81569 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_81569 ] ) ] . obo:OBI_0003225 obo:IAO_0000111 "follicle stimulating hormone concentration assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A follicle stimulating hormone assay that measures the concentration of follicle stimulating hormone in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "follicle stimulating hormone concentration assay" ; rdfs:subClassOf obo:OBI_0003224 . obo:OBI_0003226 obo:IAO_0000111 "total lymphocyte count assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A lymphocyte assay that measures the number of lymphocytes and large unstained cells in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "total lymphocyte count assay" ; rdfs:subClassOf obo:OBI_0003024 . obo:OBI_0003227 obo:IAO_0000111 "total lymphocyte percentage assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A lymphocyte assay that measures the percentage of lymphocytes and large unstained cells in a specimen." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "total lymphocyte percentage assay" ; rdfs:subClassOf obo:OBI_0003024 . obo:OBI_0003228 obo:IAO_0000111 "fluorescent immunospot assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that detects the presence of cells that secrete a material of interest (analyte). In the assay, a plate is coated with an antibody specific to the analyte of interest. These antibodies capture the analytes secreted by the cells. The analytes are then detected using fluorescent labeled secondary antibodies." ; obo:IAO_0000117 "Hector Guzman-Orozco" ; obo:IAO_0000118 "FLUOROSPOT" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/ELISpot#Mechanism_of_FluoroSpot" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1414" ; obo:IAO_0000234 "CMI-PB" ; a owl:Class ; rdfs:label "fluorescent immunospot assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001501 obo:OBI_0003368 ) ] ] . obo:OBI_0003229 obo:IAO_0000111 "plasma proteomics assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A proteomics profiling assay that detects proteins in a blood plasma specimen." ; obo:IAO_0000117 "Hector Guzman-Orozco" ; obo:IAO_0000119 "CMI-PB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1414" ; obo:IAO_0000234 "CMI-PB" ; a owl:Class ; rdfs:label "plasma proteomics assay" ; rdfs:subClassOf obo:OBI_0001318, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100016 ] . obo:OBI_0003230 obo:IAO_0000111 "T cell activation induced marker assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects the presence/amount of antigen-specific T cells without the need to identify their cytokine production. Instead, antigen-specific T cells are detected on the basis of upregulation of TCR stimulation-induced surface markers." ; obo:IAO_0000117 "Hector Guzman-Orozco" ; obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955771/" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1414" ; obo:IAO_0000234 "CMI-PB" ; a owl:Class ; rdfs:label "T cell activation induced marker assay" ; rdfs:subClassOf obo:OBI_0000916 . obo:OBI_0003231 obo:IAO_0000111 "leukapheresis" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A blood harvesting process in which white blood cells are separated from a blood specimen." ; obo:IAO_0000117 "Hector Guzman-Orozco" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Leukapheresis" ; a owl:Class ; rdfs:label "leukapheresis" ; rdfs:subClassOf obo:OBI_1110095, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000655 ] . obo:OBI_0003232 obo:IAO_0000111 "cerebrospinal fluid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that has a cerebrospinal fluid specimen as evaluant." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1429" ; a owl:Class ; rdfs:label "cerebrospinal fluid assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002502 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002502 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] ) ] . obo:OBI_0003233 obo:IAO_0000111 "endotracheal aspirate assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that has an endotracheal aspirate specimen as evaluant." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1429" ; a owl:Class ; rdfs:label "endotracheal aspirate assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002972 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002972 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] ) ] . obo:OBI_0003234 obo:IAO_0000111 "induced sputum assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that has an induced sputum specimen as evaluant." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1429" ; a owl:Class ; rdfs:label "induced sputum assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002746 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002746 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] ) ] . obo:OBI_0003235 obo:IAO_0000111 "lung assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that has a lung specimen as evaluant." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1429" ; a owl:Class ; rdfs:label "lung assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002534 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002534 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] ) ] . obo:OBI_0003236 obo:IAO_0000111 "milk assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that has a milk specimen as evaluant." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1429" ; a owl:Class ; rdfs:label "milk assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002505 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002505 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] ) ] . obo:OBI_0003237 obo:IAO_0000111 "feces assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that has a feces specimen as evaluant." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1429" ; a owl:Class ; rdfs:label "feces assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002503 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002503 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] ) ] . obo:OBI_0003238 obo:IAO_0000111 "umbilical cord blood assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that has an umbilical cord blood specimen as evaluant." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1429" ; a owl:Class ; rdfs:label "umbilical cord blood assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000012 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000012 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] ) ] . obo:OBI_0003239 obo:IAO_0000111 "saliva assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that has a saliva specimen as evaluant." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1429" ; a owl:Class ; rdfs:label "saliva assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002507 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002507 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] ) ] . obo:OBI_0003240 obo:IAO_0000111 "cerebrospinal fluid microbiology assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that detects microorganisms in a cerebrospinal fluid specimen." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1429" ; a owl:Class ; rdfs:label "cerebrospinal fluid microbiology assay" ; rdfs:subClassOf obo:OBI_0003232, obo:OBI_0003498, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002502 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002502 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0003241 obo:IAO_0000111 "endotracheal tube aspirate microbiology assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that detects microorganisms in an endotracheal aspirate specimen." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1429" ; a owl:Class ; rdfs:label "endotracheal tube aspirate microbiology assay" ; rdfs:subClassOf obo:OBI_0003233, obo:OBI_0003498, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002972 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002972 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0003242 obo:IAO_0000111 "induced sputum microbiology assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that detects microorganisms in an induced sputum specimen." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1429" ; a owl:Class ; rdfs:label "induced sputum microbiology assay" ; rdfs:subClassOf obo:OBI_0003234, obo:OBI_0003498, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002746 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002746 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0003243 obo:IAO_0000111 "blood assay datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item that is the specified output of a blood assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "blood assay datum" ; rdfs:subClassOf obo:IAO_0000027 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:IAO_0000027 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003040 ] ) ] . obo:OBI_0003244 obo:IAO_0000111 "blood microbiology datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection datum that is the specified output of a blood microbiology assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "blood microbiology datum" ; rdfs:subClassOf obo:OBI_0003064, obo:OBI_0003243 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003064 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002649 ] ) ] . obo:OBI_0003245 obo:IAO_0000111 "feces assay datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item that is the specified output of a feces assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "feces assay datum" ; rdfs:subClassOf obo:IAO_0000027 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:IAO_0000027 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003237 ] ) ] . obo:OBI_0003246 obo:IAO_0000111 "feces microbiology datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection datum that is the specified output of a feces microbiology assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "feces microbiology datum" ; rdfs:subClassOf obo:OBI_0003064, obo:OBI_0003245 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003064 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003039 ] ) ] . obo:OBI_0003247 obo:IAO_0000111 "urine assay datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item that is the specified output of a urine assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "urine assay datum" ; rdfs:subClassOf obo:IAO_0000027 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:IAO_0000027 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003043 ] ) ] . obo:OBI_0003248 obo:IAO_0000111 "urine microbiology datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection datum that is the specified output of a urine microbiology assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "urine microbiology datum" ; rdfs:subClassOf obo:OBI_0003064, obo:OBI_0003247 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003064 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003286 ] ) ] . obo:OBI_0003249 obo:IAO_0000111 "induced sputum assay datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item that is the specified output of a induced sputum assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "induced sputum assay datum" ; rdfs:subClassOf obo:IAO_0000027 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:IAO_0000027 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003234 ] ) ] . obo:OBI_0003250 obo:IAO_0000111 "biomedical laboratory organization"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organization that performs assays, processes specimens, analyses data and conducts planned processes relevant to the life sciences." ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Jie Zheng ORCID:0000-0002-2999-0103" ; obo:IAO_0000118 "laboratory" ; obo:IAO_0000119 "OBIB", "eagle-i resource ontology ERO_0000001" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1436" ; obo:IAO_0000234 "OBIB" ; a owl:Class ; rdfs:label "biomedical laboratory organization"@en ; rdfs:subClassOf obo:OBI_0000245 . obo:OBI_0003251 obo:IAO_0000111 "induced sputum microbiology datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection datum that is the specified output of an induced sputum microbiology assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "induced sputum microbiology datum" ; rdfs:subClassOf obo:OBI_0003064, obo:OBI_0003249 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003064 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003242 ] ) ] . obo:OBI_0003252 obo:IAO_0000111 "cerebrospinal fluid assay datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item that is the specified output of a cerebrospinal fluid assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "cerebrospinal fluid assay datum" ; rdfs:subClassOf obo:IAO_0000027 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:IAO_0000027 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003232 ] ) ] . obo:OBI_0003253 obo:IAO_0000111 "cerebrospinal fluid microbiology datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection datum that is the specified output of a cerebrospinal fluid microbiology assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "cerebrospinal fluid microbiology datum" ; rdfs:subClassOf obo:OBI_0003064, obo:OBI_0003252 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003064 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003240 ] ) ] . obo:OBI_0003254 obo:IAO_0000111 "endotracheal aspirate assay datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection datum that is the specified output of an endotracheal aspirate assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "endotracheal aspirate assay datum" ; rdfs:subClassOf obo:IAO_0000027 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:IAO_0000027 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003233 ] ) ] . obo:OBI_0003255 obo:IAO_0000111 "endotracheal tube aspirate microbiology datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection datum that is the specified output of an endotracheal tube aspirate microbiology assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "endotracheal tube aspirate microbiology datum" ; rdfs:subClassOf obo:OBI_0003064, obo:OBI_0003254 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003064 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003241 ] ) ] . obo:OBI_0003256 obo:IAO_0000111 "lung microbiology datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection datum that is the specified output of a lung microbiology assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "lung microbiology datum" ; rdfs:subClassOf obo:OBI_0003064 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003064 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003282 ] ) ] . obo:OBI_0003257 obo:IAO_0000111 "nasopharyngeal or oropharyngeal swab microbiology datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection datum that is the specified output of a nasopharyngeal or oropharyngeal swab microbiology assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "nasopharyngeal or oropharyngeal swab microbiology datum" ; rdfs:subClassOf obo:OBI_0003064 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003064 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003285 ] ) ] . obo:OBI_0003258 obo:IAO_0000111 "pleural fluid microbiology datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection datum that is the specified output of a pleural fluid microbiology assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "pleural fluid microbiology datum" ; rdfs:subClassOf obo:OBI_0003064 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003064 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003283 ] ) ] . obo:OBI_0003259 obo:IAO_0000111 "umbilical cord blood assay datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item that is the specified output of an umbilical cord blood assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "umbilical cord blood assay datum" ; rdfs:subClassOf obo:IAO_0000027 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:IAO_0000027 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003238 ] ) ] . obo:OBI_0003260 obo:IAO_0000111 "umbilical cord blood microbiology datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection datum that is the specified output of an umbilical cord blood microbiology assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "umbilical cord blood microbiology datum" ; rdfs:subClassOf obo:OBI_0003244, obo:OBI_0003259 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003064 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003284 ] ) ] . obo:OBI_0003261 obo:IAO_0000111 "bacteria in blood datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A blood microbiology datum that is about bacteria." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "bacteria in blood datum" ; rdfs:subClassOf obo:OBI_0003244 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003244 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_2 ] ) ] . obo:OBI_0003262 obo:IAO_0000111 "virus in blood datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A blood microbiology datum that is about a virus." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "virus in blood datum" ; rdfs:subClassOf obo:OBI_0003244 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003244 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_10239 ] ) ] . obo:OBI_0003263 obo:IAO_0000111 "eukaryota in blood datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A blood microbiology datum that is about eukaryota." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "eukaryota in blood datum" ; rdfs:subClassOf obo:OBI_0003244 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003244 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_2759 ] ) ] . obo:OBI_0003264 obo:IAO_0000111 "bacteria in feces datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A feces microbiology datum that is about bacteria." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "bacteria in feces datum" ; rdfs:subClassOf obo:OBI_0003246 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003246 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_2 ] ) ] . obo:OBI_0003265 obo:IAO_0000111 "eukaryota in feces datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A feces microbiology datum that is about eukaryota." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "eukaryota in feces datum" ; rdfs:subClassOf obo:OBI_0003246 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003246 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_2759 ] ) ] . obo:OBI_0003266 obo:IAO_0000111 "virus in feces datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A feces microbiology datum that is about a virus." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "virus in feces datum" ; rdfs:subClassOf obo:OBI_0003246 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003246 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_10239 ] ) ] . obo:OBI_0003267 obo:IAO_0000111 "eukaryota in urine datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A urine microbiology datum that is about eukaryota." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "eukaryota in urine datum" ; rdfs:subClassOf obo:OBI_0003248 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003248 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_2759 ] ) ] . obo:OBI_0003268 obo:IAO_0000111 "bacteria in induced sputum datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An induced sputum microbiology datum that is about bacteria." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "bacteria in induced sputum datum" ; rdfs:subClassOf obo:OBI_0003251 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003251 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_2 ] ) ] . obo:OBI_0003269 obo:IAO_0000111 "eukaryota in induced sputum datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An induced sputum microbiology datum that is about eukaryota." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "eukaryota in induced sputum datum" ; rdfs:subClassOf obo:OBI_0003251 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003251 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_2759 ] ) ] . obo:OBI_0003270 obo:IAO_0000111 "virus in induced sputum datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An induced sputum microbiology datum that is about a virus." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "virus in induced sputum datum" ; rdfs:subClassOf obo:OBI_0003251 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003251 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_10239 ] ) ] . obo:OBI_0003271 obo:IAO_0000111 "bacteria in endotracheal tube aspirate datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An endotracheal tube aspirate microbiology datum that is about bacteria." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "bacteria in endotracheal tube aspirate datum" ; rdfs:subClassOf obo:OBI_0003255 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003255 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_2 ] ) ] . obo:OBI_0003272 obo:IAO_0000111 "bacteria in lung datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A lung microbiology datum that is about bacteria." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "bacteria in lung datum" ; rdfs:subClassOf obo:OBI_0003256 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003256 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_2 ] ) ] . obo:OBI_0003273 obo:IAO_0000111 "eukaryota in lung datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A lung microbiology datum that is about eukaryota." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "eukaryota in lung datum" ; rdfs:subClassOf obo:OBI_0003256 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003256 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_2759 ] ) ] . obo:OBI_0003274 obo:IAO_0000111 "virus in lung datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A lung microbiology datum that is about a virus." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "virus in lung datum" ; rdfs:subClassOf obo:OBI_0003256 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003256 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_10239 ] ) ] . obo:OBI_0003275 obo:IAO_0000111 "bacteria in nasopharyngeal or oropharyngeal swab datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A nasopharyngeal or oropharyngeal swab microbiology datum that is about bacteria." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "bacteria in nasopharyngeal or oropharyngeal swab datum" ; rdfs:subClassOf obo:OBI_0003257 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003257 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_2 ] ) ] . obo:OBI_0003276 obo:IAO_0000111 "eukaryota in nasopharyngeal or oropharyngeal swab datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A nasopharyngeal or oropharyngeal swab microbiology datum that is about eukaryota." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "eukaryota in nasopharyngeal or oropharyngeal swab datum" ; rdfs:subClassOf obo:OBI_0003257 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003257 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_2759 ] ) ] . obo:OBI_0003277 obo:IAO_0000111 "virus in nasopharyngeal or oropharyngeal swab datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A nasopharyngeal or oropharyngeal swab microbiology datum that is about a virus." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "virus in nasopharyngeal or oropharyngeal swab datum" ; rdfs:subClassOf obo:OBI_0003257 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003257 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_10239 ] ) ] . obo:OBI_0003278 obo:IAO_0000111 "bacteria in pleural fluid datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pleural fluid microbiology datum that is about bacteria." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "bacteria in pleural fluid datum" ; rdfs:subClassOf obo:OBI_0003258 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003258 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_2 ] ) ] . obo:OBI_0003279 obo:IAO_0000111 "eukaryota in pleural fluid datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pleural fluid microbiology datum that is about eukaryota." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "eukaryota in pleural fluid datum" ; rdfs:subClassOf obo:OBI_0003258 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003258 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_2759 ] ) ] . obo:OBI_0003280 obo:IAO_0000111 "virus in pleural fluid datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A pleural fluid microbiology datum that is about a virus." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "virus in pleural fluid datum" ; rdfs:subClassOf obo:OBI_0003258 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003258 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_10239 ] ) ] . obo:OBI_0003281 obo:IAO_0000111 "eukaryota in umbilical cord blood datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An umbilical cord blood microbiology datum that is about eukaryota." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1428" ; a owl:Class ; rdfs:label "eukaryota in umbilical cord blood datum" ; rdfs:subClassOf obo:OBI_0003260, obo:OBI_0003263 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003260 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_2759 ] ) ] . obo:OBI_0003282 obo:IAO_0000111 "lung microbiology assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that detects microorganisms in a lung specimen." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1429" ; a owl:Class ; rdfs:label "lung microbiology assay" ; rdfs:subClassOf obo:OBI_0003235, obo:OBI_0003498, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002534 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002534 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0003283 obo:IAO_0000111 "pleural fluid microbiology assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that detects microorganisms in a pleural fluid specimen." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1429" ; a owl:Class ; rdfs:label "pleural fluid microbiology assay" ; rdfs:subClassOf obo:OBI_0003498, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002515 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002515 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0003284 obo:IAO_0000111 "umbilical cord blood microbiology assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that detects microorganisms in an umbilical cord blood specimen." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1429" ; a owl:Class ; rdfs:label "umbilical cord blood microbiology assay" ; rdfs:subClassOf obo:OBI_0002649, obo:OBI_0003238, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000012 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000012 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0003285 obo:IAO_0000111 "nasopharyngeal or oropharyngeal swab microbiology assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that detects microorganisms in a nasopharyngeal or oropharyngeal swab specimen." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1429" ; a owl:Class ; rdfs:label "nasopharyngeal or oropharyngeal swab microbiology assay" ; rdfs:subClassOf obo:OBI_0003498, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0002606 obo:OBI_0002608 ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:unionOf (obo:OBI_0002606 obo:OBI_0002608 ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0003286 obo:IAO_0000111 "urine microbiology assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that detects microorganisms in a urine specimen." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1429" ; a owl:Class ; rdfs:label "urine microbiology assay" ; rdfs:subClassOf obo:OBI_0003043, obo:OBI_0003498, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000651 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000651 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0003287 obo:IAO_0000111 "multiplex real time polymerase chain reaction assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A real time polymerase chain reaction assay in which multiple DNA sequences are amplified in a single cycle." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "multiplexed real time polymerase chain reaction assay" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1431" ; a owl:Class ; rdfs:label "multiplex real time polymerase chain reaction assay" ; rdfs:subClassOf obo:OBI_0000893 . obo:OBI_0003288 obo:IAO_0000111 "multiplex real time reverse-transcription polymerase chain reaction assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A real time reverse-transcription polymerase chain reaction assay in which multiple DNA sequences are amplified in a single cycle." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "multiplexed real time reverse-transcription polymerase chain reaction assay" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1431" ; a owl:Class ; rdfs:label "multiplex real time reverse-transcription polymerase chain reaction assay" ; rdfs:subClassOf obo:OBI_0000911 . obo:OBI_0003289 obo:IAO_0000111 "mosquito membrane feeding device" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that contains blood in a membrane penetrable to mosquitoes, designed to feed mosquitoes without the need for an animal host." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1439" ; a owl:Class ; rdfs:label "mosquito membrane feeding device" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0003290 obo:IAO_0000111 "mosquito membrane feeding assay" ; obo:IAO_0000112 "Testing the effectiveness of drugs or antibodies against parasite transmission." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that evaluates host-to-mosquito transmission of a parasite organism by feeding a specimen of host blood infected with the parasite organism to a collection of mosquitoes through a mosquito membrane feeding device and, after a given time, dissecting the mosquitoes and counting the number of parasite organisms within them." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1439" ; a owl:Class ; rdfs:label "mosquito membrane feeding assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0003289 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0003289 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:NCBITaxon_7157 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_7157 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OPL_0000232 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OPL_0000232 ] ) ] . obo:OBI_0003291 obo:IAO_0000111 "in silico design" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that is executed primarily on a computer." ; obo:IAO_0000117 "Hector Guzman-Orozco" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/In_silico" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1430" ; obo:IAO_0000234 "CMI-PB" ; a owl:Class ; rdfs:label "in silico design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0003292 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific granulysin release by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects epitope specific granulysin release by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "granulysin release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific granulysin release by T cells" ; rdfs:subClassOf obo:OBI_0001810, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0003320 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0003293 obo:IAO_0000111 "cytometric bead array assay measuring epitope specific perforin release by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometric bead array assay that detects epitope specific perforin release by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "perforin release|cytometric bead array" ; a owl:Class ; rdfs:label "cytometric bead array assay measuring epitope specific perforin release by T cells" ; rdfs:subClassOf obo:OBI_0001497, obo:OBI_0003115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003115 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0003317 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0003294 obo:IAO_0000111 "modified acid-fast stain microscopy assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A microscopy assay that uses staining to identify acid-fast organisms in a specimen and does not require heating." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "NCIT:C85736", "https://www.cdc.gov/dpdx/diagnosticprocedures/stool/staining.html" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1444" ; a owl:Class ; rdfs:label "modified acid-fast stain microscopy assay" ; rdfs:subClassOf obo:OBI_0002119, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0302887 ] . obo:OBI_0003295 obo:IAO_0000111 "positive binding datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A categorical binding datum that states that there is a significant disposition of two or more entities to form a complex." ; obo:IAO_0000117 "Bjoern Peters", "Hector Guzman-Orozco" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "positive binding datum" ; rdfs:subClassOf obo:OBI_0003141 . obo:OBI_0003296 obo:IAO_0000111 "antibodies from lymphocyte secretions assay" ; obo:IAO_0000112 "PMID: 11329444.Clin Diagn Lab Immunol. 2001 May. Development of a Novel In Vitro Assay (ALS Assay) for Evaluation of Vaccine-Induced Antibody Secretion from Circulating Mucosal Lymphocytes." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that evaluates a blood specimen for antibodies currently being produced by lymphocytes in the specimen, by separating peripheral blood mononuclear cells, culturing them, and then collecting the supernatant containing the antibodies secreted from those cells." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000118 "ALS assay", "antibodies from lymphocyte supernatant assay" ; obo:IAO_0000119 "OBI", "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1443" ; a owl:Class ; rdfs:label "antibodies from lymphocyte secretions assay" ; rdfs:subClassOf obo:OBI_0003040, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000655 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000655 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0019814 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:GO_0019814 ] ) ] . obo:OBI_0003297 obo:IAO_0000111 "tyramide signal amplification sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencing assay that uses tyramide signal amplification (TSA) to assess distance of DNA regions to a targeted nuclear compartment or protein, typically on a scale of 100-1000 nm." ; obo:IAO_0000117 "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "TSA-seq" ; obo:IAO_0000119 "EFO:0009971", "PMID:30154186" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1472" ; obo:IAO_0000234 "CFDE-4DN" ; a owl:Class ; rdfs:label "tyramide signal amplification sequencing assay" ; rdfs:subClassOf obo:OBI_0000626 . obo:OBI_0003298 obo:IAO_0000111 "DNA adenine methyltransferase identification assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay for identifying DNA binding sites for a protein by fusing it to Dam methylase, and expressing it so that bound DNA gets methylated. The methylated DNA can then be isolated and analyzed." ; obo:IAO_0000117 "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "DamID assay" ; obo:IAO_0000119 "EFO:0008704", "PMID:17545983" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1472" ; obo:IAO_0000234 "CFDE-4DN" ; a owl:Class ; rdfs:label "DNA adenine methyltransferase identification assay" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0003299 obo:IAO_0000111 "DamID-seq" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA adenine methyltransferase identification (DamID) assay in which DamID-generated DNA fragments undergo high-throughput sequencing to determine a protein's DNA-binding site." ; obo:IAO_0000117 "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000119 "4DN DCIC" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1472" ; obo:IAO_0000234 "CFDE-4DN" ; a owl:Class ; rdfs:label "DamID-seq" ; rdfs:subClassOf obo:OBI_0003298, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000626 obo:OBI_0003368 ) ] ] . obo:OBI_0003300 obo:IAO_0000111 "nucleolus-associated domain sequencing assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencing assay in which nucleoli are isolated and the DNA associated with them is sequenced to identify nucleoli-associating domains." ; obo:IAO_0000117 "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "NAD-seq" ; obo:IAO_0000119 "EFO:0009972", "PMID:31201210" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1472" ; obo:IAO_0000234 "CFDE-4DN" ; a owl:Class ; rdfs:label "nucleolus-associated domain sequencing assay" ; rdfs:subClassOf obo:OBI_0000626 . obo:OBI_0003301 obo:IAO_0000111 "DNase Hi-C assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Hi-C assay in which DNase I is used for digesting DNA fragments rather than a restriction enzyme, which can result in a higher resolution of mapped chromosome contacts." ; obo:IAO_0000117 "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000119 "EFO:0009976", "PMID:27685100" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1472" ; obo:IAO_0000234 "CFDE-4DN" ; a owl:Class ; rdfs:label "DNase Hi-C assay" ; rdfs:subClassOf obo:OBI_0002440 . obo:OBI_0003302 obo:IAO_0000111 "micro-C assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Hi-C assay which uses micrococcal nuclease digestion in place of the restriction enzyme digestion step." ; obo:IAO_0000117 "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000119 "EFO:0008808", "PMID:26119342" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1472" ; obo:IAO_0000234 "CFDE-4DN" ; a owl:Class ; rdfs:label "micro-C assay" ; rdfs:subClassOf obo:OBI_0002440 . obo:OBI_0003303 obo:IAO_0000111 "single cell combinatorial indexing Hi-C assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Hi-C assay performed on massively multiplexed single-cell samples." ; obo:IAO_0000117 "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "sci-Hi-C" ; obo:IAO_0000119 "EFO:0009977", "PMID:28135255" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1472" ; obo:IAO_0000234 "CFDE-4DN" ; a owl:Class ; rdfs:label "single cell combinatorial indexing Hi-C assay" ; rdfs:subClassOf obo:OBI_0002440 . obo:OBI_0003304 obo:IAO_0000111 "single nucleus Hi-C assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Hi-C assay performed on isolated nuclei." ; obo:IAO_0000117 "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "sn-Hi-C" ; obo:IAO_0000119 "EFO:0009978", "PMID:28355183" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1472" ; obo:IAO_0000234 "CFDE-4DN" ; a owl:Class ; rdfs:label "single nucleus Hi-C assay" ; rdfs:subClassOf obo:OBI_0002440 . obo:OBI_0003305 obo:IAO_0000111 "single cell Hi-C assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Hi-C assay performed on a single cell." ; obo:IAO_0000117 "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000119 "EFO:0009979" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1472" ; obo:IAO_0000234 "CFDE-4DN" ; a owl:Class ; rdfs:label "single cell Hi-C assay" ; rdfs:subClassOf obo:OBI_0002440 . obo:OBI_0003306 obo:IAO_0000111 "bulk Hi-C assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Hi-C assay in which the sample that is sequenced is derived from a collection of cells, such as a tissue sample or entire cell culture, and therefore provides results representative of the aggregate of sample cells." ; obo:IAO_0000117 "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000119 "4DN DCIC" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1472" ; obo:IAO_0000234 "CFDE-4DN" ; a owl:Class ; rdfs:label "bulk Hi-C assay" ; rdfs:subClassOf obo:OBI_0002440 . obo:OBI_0003307 obo:IAO_0000111 "multi-contact Hi-C assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A Hi-C assay that assesses interactions between multiple DNA fragments rather than only pairwise interactions as in traditional Hi-C. The experimental procedure of cross-linking, digestion, and ligation is performed similarly to traditional Hi-C, but after DNA is purified a long-read library is produced in which many ligated fragments may be contained in a single molecule. The library is then sequenced on a long read sequencer." ; obo:IAO_0000117 "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "MC-3C", "MC-HI-C" ; obo:IAO_0000119 "The 4D Nucleome Network" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1472" ; obo:IAO_0000234 "CFDE-4DN" ; a owl:Class ; rdfs:label "multi-contact Hi-C assay" ; rdfs:subClassOf obo:OBI_0002440 . obo:OBI_0003309 obo:IAO_0000111 "transposase-mediated analysis of chromatin looping assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencing assay designed to detect interacting genomic regions. Rather than the traditional Hi-C approach of digestion and proximity ligation, the procedure involves transposase-mediated insertion of an oligonucleotide linker between the pair of interacting regions." ; obo:IAO_0000117 "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "TrAC-Loop" ; obo:IAO_0000119 "EFO:0009982", "PMID:30150754" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1472" ; obo:IAO_0000234 "CFDE-4DN" ; a owl:Class ; rdfs:label "transposase-mediated analysis of chromatin looping assay" ; rdfs:subClassOf obo:OBI_0000626 . obo:OBI_0003310 obo:IAO_0000111 "split-pool recognition of interactions and tag extension assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A sequencing assay designed to detect multi-way interactions between nucleic acids. The procedure involves crosslinking nuclei, and then splitting the lysate among wells in a 96-well or other multi-well plate. A different barcode is ligated to the fragments in each well, and the lysates are pooled together again. This sequence of splitting, tagging, and re-combining is repeated several times so that fragments with the same sequences of barcodes represent fragments that have co-associated throughout the experiment. Finally, a sequencing library is constructed and high-throughput sequencing is performed." ; obo:IAO_0000117 "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "SPRITE" ; obo:IAO_0000119 "EFO:0009984", "PMID:29887377" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1472" ; obo:IAO_0000234 "CFDE-4DN" ; a owl:Class ; rdfs:label "split-pool recognition of interactions and tag extension assay" ; rdfs:subClassOf obo:OBI_0600047 . obo:OBI_0003311 obo:IAO_0000111 "DNA split-pool recognition of interactions and tag extension assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A split-pool recognition of interactions and tag extension (SPRITE) assay that only assays interactions between regions of genomic DNA." ; obo:IAO_0000117 "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "DNA SPRITE" ; obo:IAO_0000119 "EFO:0009985", "PMID:29887377" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1472" ; obo:IAO_0000234 "CFDE-4DN" ; a owl:Class ; rdfs:label "DNA split-pool recognition of interactions and tag extension assay" ; rdfs:subClassOf obo:OBI_0003310 . obo:OBI_0003312 obo:IAO_0000111 "RNA-DNA split-pool recognition of interactions and tag extension assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A split-pool recognition of interactions and tag extension (SPRITE) assay in which RNA in the cross-linked complexes is converted to cDNA before the initial splitting step, allowing analysis of RNA-DNA interactions." ; obo:IAO_0000117 "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "RNA-DNA SPRITE" ; obo:IAO_0000119 "EFO:0009986", "PMID:29887377" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1472" ; obo:IAO_0000234 "CFDE-4DN" ; a owl:Class ; rdfs:label "RNA-DNA split-pool recognition of interactions and tag extension assay" ; rdfs:subClassOf obo:OBI_0003310 . obo:OBI_0003313 obo:IAO_0000111 "genome architecture mapping assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencing assay designed to analyze 3D chromatin structure without relying on digestion and ligation. The procedure involves cryosectioning samples in random orientation, and then single nuclear profiles are isolated by laser microdissection. Each nuclear profile then undergoes high-throughput sequencing, and subsequent analysis can generate a matrix of inferred proximity between genomic regions." ; obo:IAO_0000117 "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "GAM" ; obo:IAO_0000119 "EFO:0009987", "PMID:28273065" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1472" ; obo:IAO_0000234 "CFDE-4DN" ; a owl:Class ; rdfs:label "genome architecture mapping assay" ; rdfs:subClassOf obo:OBI_0000626 . obo:OBI_0003314 obo:IAO_0000111 "mapping RNA-genome interactions assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A nuclear ligation assay for probing RNA-DNA interactions in the nucleus. Nuclei are crosslinked, and RNA fragments are ligated to proximal DNA fragments via a special linker molecule. After reverse transcription, high-throughput sequencing is performed." ; obo:IAO_0000117 "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "MARGI" ; obo:IAO_0000119 "EFO:0009988", "PMID:28132817" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1472" ; obo:IAO_0000234 "CFDE-4DN" ; a owl:Class ; rdfs:label "mapping RNA-genome interactions assay" ; rdfs:subClassOf obo:OBI_0002438, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000626 obo:OBI_0003368 ) ] ] . obo:OBI_0003315 obo:IAO_0000111 "assay measuring epitope specific amphiregulin production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects amphiregulin production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "amphiregulin release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific amphiregulin production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0140730 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0003316 obo:IAO_0000111 "ELISA measuring epitope specific amphiregulin production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects amphiregulin production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "amphiregulin release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific amphiregulin production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0003315 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0140730 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0003317 obo:IAO_0000111 "perforin release during T cell degranulation" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The release of perforin during cytotoxic T cell degranulation." ; obo:IAO_0000117 "Bjoern Peters", "Hector Guzman-Orozco" ; obo:IAO_0000119 "Alexander Diehl, Bjoern Peters" ; a owl:Class ; rdfs:label "perforin release during T cell degranulation" ; rdfs:subClassOf obo:GO_0035944, [ a owl:Class ; owl:intersectionOf (obo:GO_0035944 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043316 ] ) ] . obo:OBI_0003318 obo:IAO_0000111 "granzyme A release during T cell degranulation" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The release of granzyme A during cytotoxic T cell degranulation." ; obo:IAO_0000117 "Bjoern Peters", "Hector Guzman-Orozco" ; obo:IAO_0000119 "Alexander Diehl, Bjoern Peters" ; a owl:Class ; rdfs:label "granzyme A release during T cell degranulation" ; rdfs:subClassOf obo:GO_0035746, [ a owl:Class ; owl:intersectionOf (obo:GO_0035746 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043316 ] ) ] . obo:OBI_0003319 obo:IAO_0000111 "granzyme B release during T cell degranulation" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The release of granzyme B during cytotoxic T cell degranulation." ; obo:IAO_0000117 "Bjoern Peters", "Hector Guzman-Orozco" ; obo:IAO_0000119 "Alexander Diehl, Bjoern Peters" ; a owl:Class ; rdfs:label "granzyme B release during T cell degranulation" ; rdfs:subClassOf obo:GO_0071613, [ a owl:Class ; owl:intersectionOf (obo:GO_0071613 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043316 ] ) ] . obo:OBI_0003320 obo:IAO_0000111 "granulysin release during T cell degranulation" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The release of granulysin during cytotoxic T cell degranulation." ; obo:IAO_0000117 "Bjoern Peters", "Hector Guzman-Orozco" ; obo:IAO_0000119 "Alexander Diehl, Bjoern Peters" ; a owl:Class ; rdfs:label "granulysin release during T cell degranulation" ; rdfs:subClassOf obo:GO_0036262, [ a owl:Class ; owl:intersectionOf (obo:GO_0036262 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043316 ] ) ] . obo:OBI_0003321 obo:IAO_0000111 "venous blood microbiology assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A blood microbiology assay that detects a microorganism in a venous blood specimen." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1491" ; a owl:Class ; rdfs:label "venous blood microbiology assay" ; rdfs:subClassOf obo:OBI_0002649, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0100026 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100026 ] ) ] . obo:OBI_0003323 obo:IAO_0000111 "high throughput multiplexed assay measuring binding of a B cell epitope:antibody complex" ; obo:IAO_0000112 "Next-generation high-density peptide microarrays measuring antibody responses to overlapping peptides: PMID:25922409." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A B cell epitope assay that measures the binding of an antibody receptor to an epitope using a high throughput multiplexed assay." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "antibody binding|High throughput multiplexed assay" ; a owl:Class ; rdfs:label "high throughput multiplexed assay measuring binding of a B cell epitope:antibody complex" ; rdfs:subClassOf obo:OBI_1110127 . obo:OBI_0003324 obo:IAO_0000111 "high throughput multiplexed assay measuring binding of a T cell epitope:MHC:TCR complex" ; obo:IAO_0000112 "Adaptive Biotech multiplexed TCR sequencing assays: PMID:32793919." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope assay that measures the binding of T cell receptor to an epitope using a high throughput multiplexed assay." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "T cell binding|High throughput multiplexed assay" ; a owl:Class ; rdfs:label "high throughput multiplexed assay measuring binding of a T cell epitope:MHC:TCR complex" ; rdfs:subClassOf obo:OBI_1110037 . obo:OBI_0003325 obo:IAO_0000111 "high throughput multiplexed assay measuring binding of a MHC:ligand complex" ; obo:IAO_0000112 "Peptide microarray with fluorescence detection for millions of MHC binding measurements: PMID: 33705522." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A MHC ligand assay that detects the binding of a ligand to an MHC molecule using a high throughput multiplexed assay." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "MHC binding|High throughput multiplexed assay" ; a owl:Class ; rdfs:label "high throughput multiplexed assay measuring binding of a MHC:ligand complex" ; rdfs:subClassOf obo:OBI_1110126 . obo:OBI_0003326 obo:IAO_0000111 "high throughput multiplexed assay measuring MHC ligand processing and presentation" ; obo:IAO_0000112 "Mass spectrometry identified 35,367 and 28,132 HLA-class I ligands witth a false discovery rate: PMID: 29789417." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A MHC ligand assay that determines what ligands are processed and loaded onto MHC molecules by eluting ligands and identifying them using a high throughput multiplexed assay." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "ligand presentation|High throughput multiplexed assay" ; a owl:Class ; rdfs:label "high throughput multiplexed assay measuring MHC ligand processing and presentation" ; rdfs:subClassOf obo:OBI_1110125 . obo:OBI_0003327 obo:IAO_0000111 "image data set" ; obo:IAO_0000112 "The output produced by a digital imaging technique, such as microscopy, MRI, or CT." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A data set that is comprised of multidimensional structured measurements and metadata required for a morphological representation of an entity. An image data set can be the source from which an image (such as a 2D image using pixels or a 3D image using voxels) is produced." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9625-1899 \"William D. Duncan\"", "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"", "https://orcid.org/0000-0002-7245-3450 \"Lauren M. Wishnie\"", "https://orcid.org/0000-0002-9821-4132 \"Mackenzie T. Smith\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "image data set" ; rdfs:subClassOf obo:IAO_0000100, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:BFO_0000001 ] . obo:OBI_0003328 obo:IAO_0000111 "magnetic resonance image data set" ; obo:IAO_0000112 "The DICOM file produced by an MRI machine when a multiple sclerosis patient undergoes a brain scan." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An image data set whose information content originates from some MR imaging assay and is about some MRI participant." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9625-1899 \"William D. Duncan\"", "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"", "https://orcid.org/0000-0002-7245-3450 \"Lauren M. Wishnie\"", "https://orcid.org/0000-0002-9821-4132 \"Mackenzie T. Smith\"" ; obo:IAO_0000119 "MRI at a Glance, ISBN 10: 1119053552" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003327 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003327 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0003329 ] ) ] . obo:OBI_0003329 obo:IAO_0000111 "magnetic resonance imaging participant"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The subject being scanned in an MRI study, and bearor of data derived from that study." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9625-1899 \"William D. Duncan\"", "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-7245-3450 \"Lauren M. Wishnie\"", "https://orcid.org/0000-0002-9821-4132 \"Mackenzie T. Smith\"" ; a owl:Class ; rdfs:label "magnetic resonance imaging participant"@en ; rdfs:subClassOf obo:BFO_0000040 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:OBI_0003330 ] ) ] . obo:OBI_0003330 obo:IAO_0000111 "magnetic resonance imaging evaluant role"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An evaluant role that inheres in a material entity that is realized in a MR imaging assay in which MR imaging data is generated about the bearer of the evaluant role." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9625-1899 \"William D. Duncan\"", "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"", "https://orcid.org/0000-0002-7245-3450 \"Lauren M. Wishnie\"", "https://orcid.org/0000-0002-9821-4132 \"Mackenzie T. Smith\"" ; a owl:Class ; rdfs:label "magnetic resonance imaging evaluant role"@en ; rdfs:subClassOf obo:OBI_0000067 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:BFO_0000054 ; owl:someValuesFrom obo:OBI_0002985 ] ) ] . obo:OBI_0003331 obo:IAO_0000111 "raw image data set" ; obo:IAO_0000112 "The untransformed (\"k-space\") data produced by an MRI machine, prior to mathematical transformation into a form that corresponds to the anatomical structure of the brain." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An image data set that encodes measurement values produced by some instrument before undergoing a data transformation." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9625-1899 \"William D. Duncan\"", "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-1604-3078 \"Alan Ruttenberg\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"", "https://orcid.org/0000-0002-7245-3450 \"Lauren M. Wishnie\"", "https://orcid.org/0000-0002-9821-4132 \"Mackenzie T. Smith\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "raw image data set" ; rdfs:subClassOf obo:OBI_0003327 . obo:OBI_0003332 obo:IAO_0000111 "magnetic resonance pulse sequence protocol"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The NMR/MRI machine protocol about the radiofrequency pulse sequence." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"", "https://orcid.org/0000-0002-9821-4132 \"Mackenzie T. Smith\"" ; a owl:Class ; rdfs:label "magnetic resonance pulse sequence protocol"@en ; rdfs:subClassOf obo:OBI_0000272 . obo:OBI_0003333 obo:IAO_0000111 "computed image data set" ; obo:IAO_0000112 "The production of JPEG file by a digital camera." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An image data set that is the output of an image data set analysis." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9625-1899 \"William D. Duncan\"", "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-1604-3078 \"Alan Ruttenberg\"", "https://orcid.org/0000-0002-7245-3450 \"Lauren M. Wishnie\"", "https://orcid.org/0000-0002-9821-4132 \"Mackenzie T. Smith\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "computed image data set" ; rdfs:subClassOf obo:OBI_0003327 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003327 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003355 ] ) ] . obo:OBI_0003334 obo:IAO_0000111 "reconstructed magnetic resonance image data set" ; obo:IAO_0000112 "The product of a mathematical transformation of raw \"k-space\" data produced by an MRI machine into a form that represents the anatomical structure of the brain." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An image data set that is the direct output of a raw magnetic resonance image data set reconstruction or a transformation of another MR image data set." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9625-1899 \"William D. Duncan\"", "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"", "https://orcid.org/0000-0002-7245-3450 \"Lauren M. Wishnie\"", "https://orcid.org/0000-0002-9821-4132 \"Mackenzie T. Smith\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "reconstructed magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003328, obo:OBI_0003333 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003333 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0003329 ] ) ] . obo:OBI_0003335 obo:IAO_0000111 "diffusion weighted magnetic resonance image data set" ; obo:IAO_0000112 "MRI used for assessing structural integrity of brain axons and visualizing ischemia." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A type of magnetic resonance image data set collected using at least three diffusion gradients of some factor \"b,\" which is a function of the amplitude, duration, and interval of the gradiants." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "diffusion weighted magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003334 . obo:OBI_0003336 obo:IAO_0000111 "functional magnetic resonance image data set" ; obo:IAO_0000112 "MRI used for assessing brain activity via blood oxygen level dependent signal." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An magnetic resonance image data set collected as a 4D time series representing changes in brain metabolism (i.e. BOLD), typically used as a proxy for brain activity." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9625-1899 \"William D. Duncan\"", "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "functional magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003334 . obo:OBI_0003337 obo:IAO_0000111 "resting state functional magnetic resonance image data set" ; obo:IAO_0000112 "An fMRI used for assessing functional connectivity of brain regions at rest." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A type of functional MRI in which the participant is not given a task, but just rests during acquisision" ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "resting state functional magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003336 . obo:OBI_0003338 obo:IAO_0000111 "task-based functional magnetic resonance image data set" ; obo:IAO_0000112 "fMRI type used for assessing brain activity while performing an action or in response to stimuli." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A type of functional MRI in which the participant is given a task or tasks, which are timed with the acquisition" ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "task-based functional magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003336 . obo:OBI_0003339 obo:IAO_0000111 "perfusion weighted magnetic resonance image data set" ; obo:IAO_0000112 "MRI used for evaluating ischemia." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An magnetic resonance image data set that captures volume and flow of blood in the brain." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "perfusion weighted magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003334 . obo:OBI_0003340 obo:IAO_0000111 "proton density magnetic resonance image data set" ; obo:IAO_0000112 "MRI used for visualizing structure of tissue." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An magnetic resonance image data set in which the contrast emphasizes density of protons, supressing T1 and T2 effects" ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "proton density magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003334 . obo:OBI_0003341 obo:IAO_0000111 "T1 weighted magnetic resonance image data set" ; obo:IAO_0000112 "MRI used for visualizing structure of tissue where fluid is hypointense." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An magnetic resonance image acquired using a T1 weighted magnetic resonance image acquisition sequence." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "T1 weighted magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003334 . obo:OBI_0003342 obo:IAO_0000111 "post-Gd T1 weighted magnetic resonance image data set" ; obo:IAO_0000112 "MRI used for assessing breakdown of blood brain barrier." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A T1 weighted image data set where gadolidium contrast agent has been administered to the participant before image acquistion." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "post-Gd T1 weighted magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003341 . obo:OBI_0003343 obo:IAO_0000111 "T1 weighted GRE magnetic resonance image data set" ; obo:IAO_0000112 "MRI used for computational research on the structure of tissue." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "T1 weighted image data set collected using a gradient recall echo sequence." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "T1 weighted GRE magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003341 . obo:OBI_0003344 obo:IAO_0000111 "high resolution T1 weighted magnetic resonance image data set" ; obo:IAO_0000112 "MRI used for computational segmentation of tissue due to high quality." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A T1-weighted image data set acquired from an NMR/MRI machine with at least a 3 Tesla magnet and in which the voxel size is isotropic." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "high resolution T1 weighted magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003343 . obo:OBI_0003345 obo:IAO_0000111 "baseline high resolution T1 weighted magnetic resonance image data set" ; obo:IAO_0000112 "First MRI acquired as part of longitudinal study." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A T1w image data set collected at an evaluant's first visit in a study." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "baseline high resolution T1 weighted magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003343 . obo:OBI_0003346 obo:IAO_0000111 "follow-up high resolution T1 weighted magnetic resonance image data set" ; obo:IAO_0000112 "MRI acquired after the first scan as part of longitudinal study." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A T1w image data set collected at a later time than the evaluant's first scan." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "follow-up high resolution T1 weighted magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003343 . obo:OBI_0003347 obo:IAO_0000111 "T1 weighted SE magnetic resonance image data set" ; obo:IAO_0000112 "MRI used for visualizing structure of tissue, often of lower quality than a GRE sequence." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A T1 weighted image data set acquired using a spin echo sequence." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "T1 weighted SE magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003341 . obo:OBI_0003348 obo:IAO_0000111 "T2 weighted magnetic resonance image data set" ; obo:IAO_0000112 "MRI used for visualizing structure of tissue where fluid is hyperintense." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A magnetic resonance image produced by a T2 weighted magnetic resonance image acquisition sequence." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "T2 weighted magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003334 . obo:OBI_0003349 obo:IAO_0000111 "T2 weighted FLAIR magnetic resonance image data set" ; obo:IAO_0000112 "MRI used for visualizing lesions in multiple sclerosis." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A T2 weighted image data set collected using a FLAIR sequence." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "T2 weighted FLAIR magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003348 . obo:OBI_0003350 obo:IAO_0000111 "T2 weighted FSE magnetic resonance image data set" ; obo:IAO_0000112 "MRI used for visualizing structure of tissue with fast acquisition times." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "T2 weighted image collected using a fast/turbo spin echo sequence." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"" ; obo:IAO_0000118 "T2 weighted TSE magnetic resonance image data set" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "T2 weighted FSE magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003348 . obo:OBI_0003351 obo:IAO_0000111 "T2 weighted SE magnetic resonance image data set" ; obo:IAO_0000112 "MRI used for visualizing structure of tissue, often longer acquisition than FSE sequence." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A type of T2-weighted image in which the acquisition is performed using a 2D spin-echo technique" ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "T2 weighted SE magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003348 . obo:OBI_0003352 obo:IAO_0000111 "T2 weighted STIR magnetic resonance image data set" ; obo:IAO_0000112 "MRI used for visualizing structure of tissue where signal from fat is suppressed." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A T2 weighted magnetic resonance image data set collected using a STIR sequence to suppress the signal coming from fat." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "T2 weighted STIR magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003348 . obo:OBI_0003353 obo:IAO_0000111 "T2* weighted GRE magnetic resonance image data set" ; obo:IAO_0000112 "MRI better suited for identifying focal pathology than T2w SE sequences." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "T2* weighted image data set collected using a gradient echo sequence." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "T2* weighted GRE magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003348 . obo:OBI_0003354 obo:IAO_0000111 "raw magnetic resonance image data set" ; obo:IAO_0000112 "The untransformed (\"k-space\") data produced by an MRI machine, prior to mathematical transformation into a form that corresponds to the anatomical structure of the brain." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An image data set that is the direct output of an magnetic resonance imaging assay and whose values encode spatial frequencies produced by the NMR or MRI instrument." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "raw magnetic resonance image data set" ; rdfs:subClassOf obo:OBI_0003328, obo:OBI_0003331 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003331 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0003329 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002985 ] ) ] . obo:OBI_0003355 obo:IAO_0000111 "image data set analysis" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The process of deriving a data item from an image data set using computer algorithms. The produced data item can be an image data set, data measurement, or any other data item." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9625-1899 \"William D. Duncan\"", "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"", "https://orcid.org/0000-0002-7245-3450 \"Lauren M. Wishnie\"", "https://orcid.org/0000-0002-9821-4132 \"Mackenzie T. Smith\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "image data set analysis" ; rdfs:subClassOf obo:OBI_0200000, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0003327 ] . obo:OBI_0003356 obo:IAO_0000111 "raw magnetic resonance image data set reconstruction" ; obo:IAO_0000112 "A Fourier transform of raw \"k-space\" data produced into an image data set that represents the anatomical structure of the tissue examined." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A process that transforms raw magnetic resonance image data from an NMR/MRI machine into a reconstructed magnetic resonance image data set." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9625-1899 \"William D. Duncan\"", "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-2104-0568 \"Lucas M. Serra\"", "https://orcid.org/0000-0002-7245-3450 \"Lauren M. Wishnie\"", "https://orcid.org/0000-0002-9821-4132 \"Mackenzie T. Smith\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "raw magnetic resonance image data set reconstruction" ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0003355 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003355 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0003354 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0003334 ] ) ] . obo:OBI_0003357 obo:IAO_0000111 "brain region atlas image data set" ; obo:IAO_0000112 "The Desikan-Killiany brain region atlas used by the FreeSurfer software suite." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An image data set consisting of values computed from multiple image data sets encoded to represent the spatial location of individual functional or structural regions of a canonical brain." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9625-1899 \"William D. Duncan\"", "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-7245-3450 \"Lauren M. Wishnie\"", "https://orcid.org/0000-0002-9821-4132 \"Mackenzie T. Smith\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "brain region atlas image data set" ; rdfs:subClassOf obo:OBI_0003333, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0000955 ] . obo:OBI_0003358 obo:IAO_0000111 "probabilistic brain region atlas image dataset" ; obo:IAO_0000112 "A brain atlas of resting-state functional networks derived from the probability that disparate brains regions are active at the same time." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A brain atlas consisting of weighted values that respresent the probability that a voxel X is part of some brain component Y, typically derived from multiple image data sets." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-9821-4132 \"Mackenzie T. Smith\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "probabilistic brain region atlas image dataset" ; rdfs:subClassOf obo:OBI_0003357 . obo:OBI_0003359 obo:IAO_0000111 "deterministic brain region atlas image data set" ; obo:IAO_0000112 "The JHU white-matter tractography atlas used for mapping brain connectomes." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A brain atlas consisting of discrete integer values where a value X denotes a voxel is part of some brain component Y." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-9821-4132 \"Mackenzie T. Smith\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "deterministic brain region atlas image data set" ; rdfs:subClassOf obo:OBI_0003357 . obo:OBI_0003360 obo:IAO_0000111 "image segmentation map" ; obo:IAO_0000112 "The output of an algorithm that identifies pedestrians walking in a street from an image data set, where the output contains values only in the segment where the pedestrian is present." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An image data set of integer values in which each value corresponds to some shared characteristic or computed property. The values often belong to a group of pixels or voxels that share the same characteristic, such as a tissue type or anatomical region." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9625-1899 \"William D. Duncan\"", "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"", "https://orcid.org/0000-0002-7245-3450 \"Lauren M. Wishnie\"", "https://orcid.org/0000-0002-9821-4132 \"Mackenzie T. Smith\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "image segmentation map" ; rdfs:subClassOf obo:OBI_0003333 . obo:OBI_0003361 obo:IAO_0000111 "lesion mask" ; obo:IAO_0000112 "The output produced by a manual or automated segmentation of lesions from a brain MRI." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An image data set where voxel intensity values greater than zero encode the location of some brain lesion and voxels outside the lesion have an intensity value of zero." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "lesion mask" ; rdfs:subClassOf obo:OBI_0003360 . obo:OBI_0003362 obo:IAO_0000111 "T1 lesion mask" ; obo:IAO_0000112 "The output produced by a manual or automated segmentation of lesions from a T1w MRI." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A lesion mask where the lesions are derived from a T1 weighted image data set." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "T1 lesion mask" ; rdfs:subClassOf obo:OBI_0003361 . obo:OBI_0003363 obo:IAO_0000111 "T2 FLAIR lesion mask" ; obo:IAO_0000112 "The output produced by a manual or automated segmentation of lesions from a T2w FLAIR MRI." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A lesion mask where the lesions are derived from a T2 FLAIR image data set." ; obo:IAO_0000117 "https://orcid.org/0000-0001-9676-7377 \"Alexander D. Bartnik\"", "https://orcid.org/0000-0001-9990-8331 \"Alexander D. Diehl\"" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1481" ; a owl:Class ; rdfs:label "T2 FLAIR lesion mask" ; rdfs:subClassOf obo:OBI_0003361 . obo:OBI_0003365 obo:IAO_0000111 "milk assay datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item that is the specified output of a milk assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1515" ; a owl:Class ; rdfs:label "milk assay datum" ; rdfs:subClassOf obo:IAO_0000027 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:IAO_0000027 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003236 ] ) ] . obo:OBI_0003366 obo:IAO_0000111 "organism diagnostic process"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A drawing a conclusion based on data that involves the interpretation of data about a given organism (human, animal, or plant) and the assertion to the effect that the organism has or had a disease, disorder, or syndrome of a certain type, or none of these as output." ; obo:IAO_0000117 "Jie Zheng" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1505" ; a owl:Class ; rdfs:label "organism diagnostic process"@en ; rdfs:subClassOf obo:OBI_0000338, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0003367 ] . obo:OBI_0003367 obo:IAO_0000111 "diagnosis of an organism"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A conclusion based on data about that an organism has a disease, disorder, or syndrome of a certain type, or none of these." ; obo:IAO_0000117 "Jie Zheng" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1505" ; a owl:Class ; rdfs:label "diagnosis of an organism"@en ; rdfs:subClassOf obo:OBI_0001909, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003366 ] . obo:OBI_0003368 obo:IAO_0000111 "detection technique" ; obo:IAO_0000112 "Using a radioactivity detection assay as part of a tritiated thymidine incorporation assay to determine the degree to which cells are replicating by detecting radioactivity of tritiated thymidine, where radioactivity of tritiated thymidine in a cell is a proxy for cells that were actively replicating." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay (A) that is part of another assay (B), where the target entities of A and B are disjoint, and the target entity of A is a proxy for the target of assay B." ; obo:IAO_0000117 "Bjoern Peters", "Hector Guzman-Orozco" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1488" ; a owl:Class ; rdfs:label "detection technique" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_0000070 ] . obo:OBI_0003369 obo:IAO_0000111 "assay kit" ; obo:IAO_0000112 "Glutathione S-Transferase (GST) Assay Kit: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/101/301/cs0410bul.pdf" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device that consists of reagents and devices that enable the performance of a specific type of assay, which could, in addition, require specific instruments not included in the kit." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "OBI, VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1456" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "assay kit" ; rdfs:subClassOf obo:OBI_0000968 . obo:OBI_0003371 obo:IAO_0000111 "epitope specific XCL1 release by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A biological process where T cells produce XCL1 resulting from the recognition of a T cell epitope." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "epitope specific XCL1 release by T cells" ; rdfs:subClassOf obo:GO_0140779, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0140779 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_0003372 obo:IAO_0000111 "assay measuring epitope specific lymphotactin production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects lymphotactin production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "lymphotactin release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific lymphotactin production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0140779 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0003373 obo:IAO_0000111 "ELISA measuring epitope specific lymphotactin production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects lymphotactin production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "lymphotactin release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific lymphotactin production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0003372 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0140779 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0003374 obo:IAO_0000111 "remote patient assessment"@en ; obo:IAO_0000112 "A telephone or video remote patient assessment conducted between a physician and patient."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism diagnostic process which involves a remote assessment of a patient by a clinician."@en ; obo:IAO_0000117 ; obo:IAO_0000118 "telehealth patient assessment"@en ; obo:IAO_0000119 ; dc:date "2022-05-02T14:15:39Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "remote patient assessment"@en ; rdfs:subClassOf obo:OBI_0003366 . obo:OBI_0003380 obo:IAO_0000111 "placental blood specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from placental blood." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "placental blood specimen" ; rdfs:subClassOf obo:OBI_2000009 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_8470000 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_0003381 obo:IAO_0000111 "placental blood microbiology assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A blood microbiology assay that detects microorganisms in a placental blood specimen." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1297" ; a owl:Class ; rdfs:label "placental blood microbiology assay" ; rdfs:subClassOf obo:OBI_0002649, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0003380 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0003380 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0003382 obo:IAO_0000111 "placental blood microbiology datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection datum that is the specified output of a placental blood microbiology assay." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1297" ; a owl:Class ; rdfs:label "placental blood microbiology datum" ; rdfs:subClassOf obo:OBI_0003244 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003064 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003381 ] ) ] . obo:OBI_0003383 obo:IAO_0000111 "eukaryota in placental blood datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A placental blood microbiology datum that is about eukaryota." ; obo:IAO_0000117 "John Judkins" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1297" ; a owl:Class ; rdfs:label "eukaryota in placental blood datum" ; rdfs:subClassOf obo:OBI_0003263, obo:OBI_0003382 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003382 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:NCBITaxon_2759 ] ) ] . obo:OBI_0003384 obo:IAO_0000111 "synaptosome preparation process" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A material component separation process where a synaptic terminal is isolated from a neuron by mild homogenization of nervous tissue under isotonic conditions and subsequent fractionation using differential and density gradient centrifugation."@en ; obo:IAO_0000117 "Michelle Giglio"@en, "Suvarna Nadendla"@en ; obo:IAO_0000119 "url:https://en.wikipedia.org/wiki/Synaptosome"@en ; obo:IAO_0000234 "CFDE-GlyGen" ; a owl:Class ; rdfs:label "synaptosome preparation process"@en ; rdfs:subClassOf obo:OBI_0600014 . obo:OBI_0003385 obo:IAO_0000111 "has assay target context" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A relation between the target entity of an assay and a material entity, where the material entity is the environment in which the target entity of an assay is measured, such as a live mouse, cell culture, test tube, etc." ; obo:IAO_0000117 "Hector Guzman-Orozco" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1516" ; a owl:ObjectProperty ; rdfs:label "has assay target context" ; rdfs:range obo:BFO_0000040 . obo:OBI_0003386 obo:IAO_0000111 "Illumina HiSeq 1500" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencer which is manufactured by the Illumina corporation, with a single flow cell. Built upon sequencing by synthesis technology, the machine employs dual surface imaging and offers two high-output options and one rapid-run option." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "HiSeq 1500" ; obo:IAO_0000119 "https://jp.support.illumina.com/content/dam/illumina-support/documents/documentation/system_documentation/hiseq1500/hiseq-1500-system-guide-15035788-03.pdf" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Illumina HiSeq 1500" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000759 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003387 obo:IAO_0000111 "NextSeq 550" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencer manufactured by the Illumina corporation, which provides the increased flexibility of microarray scanning in addition to sequencing." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000119 "https://www.illumina.com/systems/sequencing-platforms/nextseq.html" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "NextSeq 550" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000759 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003388 obo:IAO_0000111 "Agilent-026655 Whole Mouse Genome Microarray 4x44K v2" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA microarray manufactured with Agilent 60-mer SurePrint Technology .The SurePrint G3 Mouse Gene Expression 4x44K v2 Microarray provide full coverage of the mouse transcriptome using the latest annotation databases, including long non-coding RNA(lncRNA). Each glass slide is formatted with four high-definition 44K arrays." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000119 "https://www.agilent.com/cs/library/brochures/IBS-231%20genomics%20catalog%20mech%20FINAL.pdf" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Agilent-026655 Whole Mouse Genome Microarray 4x44K v2" ; rdfs:subClassOf obo:OBI_0400148, [ a owl:Restriction ; owl:hasValue obo:OBI_0000765 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003389 obo:IAO_0000111 "Agilent-030493 SurePrint G3 Mouse Exon 4x180K Microarray" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA microarray manufactured with Agilent 60-mer SurePrint Technology for studying exon-level gene expression changes. The SurePrint G3 Mouse Exon 4x180K Microarray include probes targeting individual exons. Each glass slide formatted with four 180K arrays." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000119 "https://www.agilent.com/cs/library/brochures/5990-6928en_lo.pdf" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Agilent-030493 SurePrint G3 Mouse Exon 4x180K Microarray" ; rdfs:subClassOf obo:OBI_0400148, [ a owl:Restriction ; owl:hasValue obo:OBI_0000765 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003390 obo:IAO_0000111 "Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA microarray manufactured with Agilent 60-mer SurePrint technology which provides comprehensive coverage of genes and transcripts using the latest annotation databases. The SurePrint G3 Mouse Gene Expression 8x60K v2 Microarray features complete coverage of established RefSeq coding transcripts (NM) from the latest build and updated long non-coding RNA (lncRNA) content to ensure relevant research.Each glass slide formatted with eight high-definition 60K arrays." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000119 "https://www.agilent.com/cs/library/usermanuals/public/G4140-90050_GeneExpression_TwoColor_6.9.pdf" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray" ; rdfs:subClassOf obo:OBI_0400148, [ a owl:Restriction ; owl:hasValue obo:OBI_0000765 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003391 obo:IAO_0000111 "Affymetrix Mouse Genome 430 2.0 Array" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA microarray manufactured by Affymetrix, which includes complete coverage of the GeneChip Mouse Expression Set 430, for analysis of over 39,000 transcripts and variants from more than 34,000 well-characterized mouse genes and UniGene clusters, on a single array. The sequences for this array were selected from GenBank™, dbEST, and RefSeq., and sequence clusters cretaed from the UniGene database." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "GeneChip Mouse Genome 430 2.0 Array" ; obo:IAO_0000119 "https://www.thermofisher.com/order/catalog/product/900497" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Affymetrix Mouse Genome 430 2.0 Array" ; rdfs:subClassOf obo:OBI_0400148, [ a owl:Restriction ; owl:hasValue obo:OBI_0000462 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003392 obo:IAO_0000111 "Affymetrix Mouse Genome 430A 2.0 Array" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA microarray manufactured by Affymetrix for gene expression analysis focusing on approximately 14,000 well-characterized genes in the transcribed mouse genome using single-array cartridge. Sequences used in the design of the array were selected from GenBank™, dbEST, and RefSeq. The sequence clusters were created from the UniGene database." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "GeneChip Mouse Genome 430A 2.0 Array" ; obo:IAO_0000119 "https://www.thermofisher.com/order/catalog/product/900500TS?SID=srch-srp-900500TS" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Affymetrix Mouse Genome 430A 2.0 Array" ; rdfs:subClassOf obo:OBI_0400148, [ a owl:Restriction ; owl:hasValue obo:OBI_0000462 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003393 obo:IAO_0000111 "Affymetrix Mouse Gene 1.0 ST Array" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA microarray manufactured by Affymetrix, which is a whole-transcript array that includes probes to measure both messenger (mRNA) and long intergenic non-coding RNA transcripts (lincRNA). This whole-transcript array design provides a complete expression profile of mRNA as well as the intermediary lincRNA transcripts that impact the mRNA expression profile." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "GeneChip Mouse Gene 1.0 ST Array" ; obo:IAO_0000119 "https://www.thermofisher.com/order/catalog/product/901168" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Affymetrix Mouse Gene 1.0 ST Array" ; rdfs:subClassOf obo:OBI_0400148, [ a owl:Restriction ; owl:hasValue obo:OBI_0000462 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003394 obo:IAO_0000111 "Affymetrix Mouse Gene 2.1 ST Array" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA microarray manufactured by Affymetrix, which is a whole-transcript array that includes probes to measure both messenger (mRNA) and long intergenic non-coding RNA transcripts (lincRNA).To supplement the lincRNA data contained in RefSeq, we used sequence and transcript data from lncRNA db." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "GeneChip Mouse Gene 2.1 ST Array" ; obo:IAO_0000119 "https://www.thermofisher.com/document-connect/document-connect.html?url=https%3A%2F%2Fassets.thermofisher.com%2FTFS-Assets%2FLSG%2Fbrochures%2Fmouse_gene_array_datasheet.pdf" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Affymetrix Mouse Gene 2.1 ST Array" ; rdfs:subClassOf obo:OBI_0400148, [ a owl:Restriction ; owl:hasValue obo:OBI_0000462 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003395 obo:IAO_0000111 "Affymetrix Rhesus Macaque Genome Array" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA microarray manufactured by Affymetrix,which is a single-labeled high-density oligonucleotide array, designed to study gene expression in the rhesus animal model and to interrogate rhesus transcripts orthologous to the 3' end of human transcripts. The array consists of over 52,000 probe sets representing more than 20,000 genes, and several relevant viral organisms for studying host-disease immune response." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "GeneChip Rhesus Macaque Genome Array" ; obo:IAO_0000119 "https://www.thermofisher.com/document-connect/document-connect.html?url=https%3A%2F%2Fassets.thermofisher.com%2FTFS-Assets%2FLSG%2Fmanuals%2FMAN0017705_702023_RhesusArray_PI.pdf" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Affymetrix Rhesus Macaque Genome Array" ; rdfs:subClassOf obo:OBI_0400148, [ a owl:Restriction ; owl:hasValue obo:OBI_0000462 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003396 obo:IAO_0000111 "Affymetrix Human Transcriptome Array 2.0" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA microarray manufactured by Affymetrix, to go beyond gene-level expression profiling to accurately detect all known transcript isoforms produced by a gene. The array design covers >245,000 coding transcripts, >40,000 non-coding transcripts and >339,000 probe sets covering exon-exon junctions, thus ensuring uniform coverage of the transcriptome." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "GeneChip Human Transcriptome Array 2.0" ; obo:IAO_0000119 "https://www.thermofisher.com/document-connect/document-connect.html?url=https%3A%2F%2Fassets.thermofisher.com%2FTFS-Assets%2FLSG%2Fbrochures%2Fhta_array_2_0_datasheet.pdf" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Affymetrix Human Transcriptome Array 2.0" ; rdfs:subClassOf obo:OBI_0400148, [ a owl:Restriction ; owl:hasValue obo:OBI_0000462 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003397 obo:IAO_0000111 "Affymetrix Human Genome U219 Array" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA microarray manufactured by Affymetrix, which comprises more than 530,000 probes covering more than 36,000 transcripts and variants, which represent more than 20,000 genes mapped through RefSeq or via UniGene annotation. Sequences used in the design of the array were selected from the RefSeq version 36, UniGene database 219, and full-length human mRNAs from GenBank™." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "Applied Biosystems GeneChip PrimeView Human Gene Expression Array" ; obo:IAO_0000119 "https://www.thermofisher.com/document-connect/document-connect.html?url=https%3A%2F%2Fassets.thermofisher.com%2FTFS-Assets%2FLSG%2Fmanuals%2FMAN0017681_703036_GeneChipPrimeViewArray_PI.pdf" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Affymetrix Human Genome U219 Array" ; rdfs:subClassOf obo:OBI_0400148, [ a owl:Restriction ; owl:hasValue obo:OBI_0000462 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003398 obo:IAO_0000111 "Affymetrix Human Gene 2.0 ST Array" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA microarray manufactured by Affymetrix, which provides the most accurate, sensitive, and comprehensive measurement of protein coding (mRNA) and long intergenic non-coding RNA (lincRNA) transcripts. The array design covers >33,500 coding transcripts and >11,000 lincRNA transcripts thus enabling researchers to understand whole-transcriptome gene expression at the gene and exon levels, which allows the study of transcript variants and alternative splicing events." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000118 "GeneChip Human Gene 2.0 ST Array" ; obo:IAO_0000119 "https://www.thermofisher.com/document-connect/document-connect.html?url=https%3A%2F%2Fassets.thermofisher.com%2FTFS-Assets%2FLSG%2Fbrochures%2Fhugene_2_st_datasheet.pdf" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Affymetrix Human Gene 2.0 ST Array" ; rdfs:subClassOf obo:OBI_0400148, [ a owl:Restriction ; owl:hasValue obo:OBI_0000462 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003399 obo:IAO_0000111 "Affymetrix Clariom S Assay, Human" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA microarray manufactured by Affymetrix, to obtain a gene-level view of the human transcriptome. The assay design covers >20,000 well-annotated genes, providing researchers with the ability to perform gene-level expression profiling studies, to identify expression biomarkers , and to quickly assess changes in key genes and pathways." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000119 "https://www.thermofisher.com/order/catalog/product/902926#1_1" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Affymetrix Clariom S Assay, Human" ; rdfs:subClassOf obo:OBI_0400148, [ a owl:Restriction ; owl:hasValue obo:OBI_0000462 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003400 obo:IAO_0000111 "Affymetrix Clariom S Assay, Mouse" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA microarray manufactured by Affymetrix, to obtain a gene-level view of the mouse transcriptome. The assay design covers >20,000 well-annotated genes, providing researchers with the ability to perform gene-level expression profiling studies, to identify expression biomarkers, and to quickly assess changes in key genes and pathways." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000119 "https://www.thermofisher.com/order/catalog/product/902931?SID=srch-srp-902931," ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Affymetrix Clariom S Assay, Mouse" ; rdfs:subClassOf obo:OBI_0400148, [ a owl:Restriction ; owl:hasValue obo:OBI_0000462 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003401 obo:IAO_0000111 "Illumina HumanHT-12 V4.0 expression beadchip" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An Illumina BeadChip which employs direct-hybridization assay, for whole-genome expression profiling and expression-based quantitative trait loci (eQTL) studies. This BeadChip contains 12 arrays, each featuring more than 48,000 probes, targeting more than 31,000 annotated genes, providing genome-wide coverage of well-characterized genes, gene candidates, and splice variants." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000119 "https://www.illumina.com/documents/products/technotes/technote_humanht_12_imputation.pdf" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Illumina HumanHT-12 V4.0 expression beadchip" ; rdfs:subClassOf obo:OBI_0001869, [ a owl:Restriction ; owl:hasValue obo:OBI_0000759 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003402 obo:IAO_0000111 "Illumina MouseRef-8 v2.0 beadchip" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An Illumina BeadChip which employs direct-hybridization assay, for whole-genome expression profiling in the mouse.This Beadchip contains 8 microarrays, featuring more than 25,000 probes per array, derived from the NCBI RefSeq database and supplemented with MEEBO and RIKEN FANTOM2 content." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000119 "https://support.illumina.com/content/dam/illumina-support/documents/documentation/chemistry_documentation/arraykits/whole-genome-gene-expression/WGGEX_Direct_Hybridization_Assay_Guide_11322355_A.pdf, https://www.illumina.com/documents/products/datasheets/datasheet_gene_exp_analysis.pdf" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Illumina MouseRef-8 v2.0 beadchip" ; rdfs:subClassOf obo:OBI_0001869, [ a owl:Restriction ; owl:hasValue obo:OBI_0000759 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003403 obo:IAO_0000111 "Affymetrix Mouse Exon Junction Array" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA microarray manufactured by Affymetrix, used to identify exon-exon junctions associated with alternate splice variants in the mouse transcriptome." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000119 "https://academic.oup.com/bioinformatics/article/26/2/268/209989" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Affymetrix Mouse Exon Junction Array" ; rdfs:subClassOf obo:OBI_0400148, [ a owl:Restriction ; owl:hasValue obo:OBI_0000462 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003404 obo:IAO_0000111 "Affymetrix Human Exon Junction Array" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA microarray manufactured by Affymetrix, used to identify exon-exon junctions associated with alternate splice variants in the human transcriptome." ; obo:IAO_0000117 "Jain Aluvathingal", "Michelle Giglio", "Suvarna Nadendla" ; obo:IAO_0000119 "https://academic.oup.com/bioinformatics/article/26/2/268/209989" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1546" ; obo:IAO_0000234 "gEAR" ; a owl:Class ; rdfs:label "Affymetrix Human Exon Junction Array" ; rdfs:subClassOf obo:OBI_0400148, [ a owl:Restriction ; owl:hasValue obo:OBI_0000462 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003413 obo:IAO_0000111 "administering substance in vivo to cause disease" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An administration of substance in vivo with the intention to induce disease in the organism." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "administering substance in vivo to cause disease" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0003607 ] . obo:OBI_0003414 obo:IAO_0000111 "administering substance in vivo to reduce or prevent disease" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An administration of substance in vivo with the intention to reduce the symptoms of or prevent development of a disease in the organism." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "administering substance in vivo to reduce or prevent disease" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0003608 obo:OBI_0003609 obo:OBI_0003614 ) ] ] . obo:OBI_0003415 obo:IAO_0000111 "peripheral blood mononuclear cell specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A processed specimen that is extracted from whole blood using gradient centrifugation that separates the blood into a layer of peripheral blood mononuclear cells under the top layer of plasma. It contains lymphocytes, monocytes or macrophages that are critical components in the immune system." ; obo:IAO_0000117 "Chris Stoeckert", "Jie Zheng" ; obo:IAO_0000118 "PBMC specimen" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Peripheral_blood_mononuclear_cell" ; a owl:Class ; rdfs:label "peripheral blood mononuclear cell specimen" ; rdfs:subClassOf obo:OBI_0100051, [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:CL_2000001 ] ) ], [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] . obo:OBI_0003416 obo:IAO_0000111 "mid-upper arm circumference datum" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A length measurement datum that is the specified output of an assay measuring the length around an upper arm, taken midway along the upper arm." ; obo:IAO_0000119 "The Mother and Child Health and Education Trust" ; a owl:Class ; rdfs:label "mid-upper arm circumference datum" ; rdfs:subClassOf obo:IAO_0000408, [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000122 [ a owl:Restriction ; owl:onProperty obo:RO_0000080 ; owl:someValuesFrom obo:UBERON_0001460 ] ) ] ] . obo:OBI_0003417 obo:IAO_0000111 "antigen specific antibodies assay datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data item that is the specified output of an antigen specific antibodies assay." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1526" ; a owl:Class ; rdfs:label "antigen specific antibodies assay datum" ; rdfs:subClassOf obo:IAO_0000027 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:IAO_0000027 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002145 ] ) ] . obo:OBI_0003418 obo:IAO_0000111 "antigen specific antibodies in blood assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antigen specific antibodies assay that has a blood specimen as evaluant." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1526" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "antigen specific antibodies in blood assay" ; rdfs:subClassOf obo:OBI_0002145, obo:OBI_0003040, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000655 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000655 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0003419 obo:IAO_0000111 "antigen specific antibodies in milk assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antigen specific antibodies assay that has a milk specimen as evaluant." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1526" ; obo:IAO_0000234 "VEuPathDB" ; a owl:Class ; rdfs:label "antigen specific antibodies in milk assay" ; rdfs:subClassOf obo:OBI_0002145, obo:OBI_0003236, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002505 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002505 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0003420 obo:IAO_0000111 "antigen specific antibodies in blood assay datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antigen specific antibodies assay datum that is the specified output of an antigen specific antibodies in blood assay." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1526" ; a owl:Class ; rdfs:label "antigen specific antibodies in blood assay datum" ; rdfs:subClassOf obo:OBI_0003243, obo:OBI_0003417 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003417 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003040 ] ) ] . obo:OBI_0003421 obo:IAO_0000111 "antigen specific antibodies in milk assay datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antigen specific antibodies assay datum that is the specified output of an antigen specific antibodies in milk assay." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1526" ; a owl:Class ; rdfs:label "antigen specific antibodies in milk assay datum" ; rdfs:subClassOf obo:OBI_0003365, obo:OBI_0003417 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003417 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003236 ] ) ] . obo:OBI_0003422 obo:IAO_0000111 "enzymatic activity level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay in which the level of catalytic activity of an enzyme is determined." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "enzymatic activity level assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0003824 ] ] . obo:OBI_0003423 obo:IAO_0000111 "5'-nucleotidase activity level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An enzymatic activity level assay that measures the activity of 5'-nucleotidase in a sample." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "5'-nucleotidase activity level assay" ; rdfs:subClassOf obo:OBI_0003422 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003422 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0008253 ] ] ) ] . obo:OBI_0003424 obo:IAO_0000111 "alanine aminotransferase activity level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An enzymatic activity level assay that measures the activity of alanine aminotransferase in a sample." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "alanine aminotransferase activity level assay" ; rdfs:subClassOf obo:OBI_0003422 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003422 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0004021 ] ] ) ] . obo:OBI_0003425 obo:IAO_0000111 "alkaline phosphatase activity level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An enzymatic activity level assay that measures the activity of alkaline phosphatase in a sample." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "alkaline phosphatase activity level assay" ; rdfs:subClassOf obo:OBI_0003422 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003422 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0004035 ] ] ) ] . obo:OBI_0003426 obo:IAO_0000111 "amylase activity level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An enzymatic activity level assay that measures the activity of amylase in a sample." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "amylase activity level assay" ; rdfs:subClassOf obo:OBI_0003422 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003422 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0016160 ] ] ) ] . obo:OBI_0003427 obo:IAO_0000111 "aspartate aminotransferase activity level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An enzymatic activity level assay that measures the activity of aspartate aminotransferase in a sample." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "aspartate aminotransferase activity level assay" ; rdfs:subClassOf obo:OBI_0003422 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003422 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0004069 ] ] ) ] . obo:OBI_0003428 obo:IAO_0000111 "cholinesterase activity level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An enzymatic activity level assay that measures the activity of cholinesterase in a sample." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "cholinesterase activity level assay" ; rdfs:subClassOf obo:OBI_0003422 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003422 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0004104 ] ] ) ] . obo:OBI_0003429 obo:IAO_0000111 "creatine kinase activity level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An enzymatic activity level assay that measures the activity of creatine kinase in a sample." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "creatine kinase activity level assay" ; rdfs:subClassOf obo:OBI_0003422 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003422 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0004111 ] ] ) ] . obo:OBI_0003430 obo:IAO_0000111 "gamma-glutamyltransferase activity level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An enzymatic activity level assay that measures the activity of gamma-glutamyltransferase in a sample." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "gamma-glutamyltransferase activity level assay" ; rdfs:subClassOf obo:OBI_0003422 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003422 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0047823 ] ] ) ] . obo:OBI_0003431 obo:IAO_0000111 "glutamate dehydrogenase activity level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An enzymatic activity level assay that measures the activity of glutamate dehydrogenase in a sample." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "glutamate dehydrogenase activity level assay" ; rdfs:subClassOf obo:OBI_0003422 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003422 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0004353 ] ] ) ] . obo:OBI_0003432 obo:IAO_0000111 "isocitrate dehydrogenase activity level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An enzymatic activity level assay that measures the activity of isocitrate dehydrogenase in a sample." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "isocitrate dehydrogenase activity level assay" ; rdfs:subClassOf obo:OBI_0003422 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003422 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0004448 ] ] ) ] . obo:OBI_0003433 obo:IAO_0000111 "lactate dehydrogenase activity level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An enzymatic activity level assay that measures the activity of lactate dehydrogenase in a sample." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "lactate dehydrogenase activity level assay" ; rdfs:subClassOf obo:OBI_0003422 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003422 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0004457 ] ] ) ] . obo:OBI_0003434 obo:IAO_0000111 "sorbitol dehydrogenase activity level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An enzymatic activity level assay that measures the activity of sorbitol dehydrogenase in a sample." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "sorbitol dehydrogenase activity level assay" ; rdfs:subClassOf obo:OBI_0003422 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003422 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0003939 ] ] ) ] . obo:OBI_0003435 obo:IAO_0000111 "acyl-CoA oxidase activity level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An enzymatic activity level assay that measures the activity of Acyl-CoA oxidase in a sample." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "acyl-CoA oxidase activity level assay" ; rdfs:subClassOf obo:OBI_0003422 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003422 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0003997 ] ] ) ] . obo:OBI_0003436 obo:IAO_0000111 "N-acetyl-beta-glucosaminidase activity level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An enzymatic activity level assay that measures the activity of N-acetyl-beta-glucosaminidase in a sample." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "N-acetyl-beta-glucosaminidase activity level assay" ; rdfs:subClassOf obo:OBI_0003422 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003422 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0016231 ] ] ) ] . obo:OBI_0003437 obo:IAO_0000111 "ribonuclease activity level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An enzymatic activity level assay that measures the activity of ribonuclease in a sample." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "ribonuclease activity level assay" ; rdfs:subClassOf obo:OBI_0003422 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003422 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0004540 ] ] ) ] . obo:OBI_0003438 obo:IAO_0000111 "galactosidase activity level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An enzymatic activity level assay that measures the activity of galactosidase in a sample." ; obo:IAO_0000117 "James A. Overton" ; a owl:Class ; rdfs:label "galactosidase activity level assay" ; rdfs:subClassOf obo:OBI_0003422 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003422 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0015925 ] ] ) ] . obo:OBI_0003454 obo:IAO_0000111 "Mosquito Magnet Liberty Plus trap" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An arthropod trap that is designed to emit a combination of carbon dioxide, heat, water, and oct-1-en-3-ol attractants while simultaneously using suction to trap arthropods. This trap has the same design as the Mosquito Magnet Pro trap but is smaller, is more lightweight, and uses a main line electricity supply instead of propane to power itself. Both use propane to produce the arthropod attractor." ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1523" ; a owl:Class ; rdfs:label "Mosquito Magnet Liberty Plus trap" ; rdfs:subClassOf obo:OBI_0002920 . obo:OBI_0003455 obo:IAO_0000111 "tumor challenge" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The administration of a malignant cell to a host." ; obo:IAO_0000117 "Hector Guzman-Orozco" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "tumor challenge" ; rdfs:subClassOf obo:OBI_0003456, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000319 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:CL_0001064 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000725 ] ) ] ] ) ] ] . obo:OBI_0003456 obo:IAO_0000111 "in vivo challenge" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The administration of a challenge to a live host." ; obo:IAO_0000117 "Hector Guzman-Orozco" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "in vivo challenge" ; rdfs:subClassOf obo:OBI_0600007 . obo:OBI_0003457 obo:IAO_0000111 "epitope protection from infectious challenge experiment based on survival" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An epitope protection from infectious challenge experiment that determines the success of the epitope intervention based on increased survival of the host compared to controls." ; obo:IAO_0000117 "Hector Guzman-Orozco" ; obo:IAO_0000118 "survival after infectious challenge" ; obo:IAO_0000119 "IEDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1594" ; a owl:Class ; rdfs:label "epitope protection from infectious challenge experiment based on survival" ; rdfs:subClassOf obo:OBI_0001179 . obo:OBI_0003458 obo:IAO_0000111 "epitope protection from tumor challenge experiment based on burden" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An epitope protection from tumor challenge experiment in which the readout is a reduction in the presence of malignant cells in the host compared to controls." ; obo:IAO_0000117 "Hector Guzman-Orozco" ; obo:IAO_0000118 "burden after tumor challenge" ; obo:IAO_0000119 "IEDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1594" ; a owl:Class ; rdfs:label "epitope protection from tumor challenge experiment based on burden" ; rdfs:subClassOf obo:OBI_0001183 . obo:OBI_0003459 obo:IAO_0000111 "epitope protection from tumor challenge experiment based on survival" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An epitope protection from tumor challenge experiment that determines the success of the epitope intervention based on increased survival of the host compared to controls." ; obo:IAO_0000117 "Hector Guzman-Orozco" ; obo:IAO_0000118 "survival after tumor challenge" ; obo:IAO_0000119 "IEDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1594" ; a owl:Class ; rdfs:label "epitope protection from tumor challenge experiment based on survival" ; rdfs:subClassOf obo:OBI_0001183 . obo:OBI_0003460 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific protection from pathogen challenge" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring T cell epitope specific protection from pathogen challenge." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "protection from pathogen challenge|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific protection from pathogen challenge" ; rdfs:subClassOf obo:OBI_0001179, obo:OBI_0002073 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001179 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000712 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003414 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] ) ] . obo:OBI_0003461 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific protection from tumor challenge" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring T cell epitope specific protection from tumor challenge." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "protection from tumor challenge|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific protection from tumor challenge" ; rdfs:subClassOf obo:OBI_0001183, obo:OBI_0002073 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001183 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003414 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003455 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] ) ] . obo:OBI_0003462 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific protection from other challenge" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring T cell epitope specific protection from a challenge other than pathogen, infection, or tumor." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "protection from other challenge|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific protection from other challenge" ; rdfs:subClassOf obo:OBI_0002073 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003414 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:complementOf [ a owl:Class ; owl:unionOf (obo:OBI_0000712 obo:OBI_0003455 ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] ) ] . obo:OBI_0003463 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific survival after tumor challenge" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring T cell epitope specific protection from tumor challenge using survival." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "survival from tumor challenge|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific survival after tumor challenge" ; rdfs:subClassOf obo:OBI_0003459, obo:OBI_0003461 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003459 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003414 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003455 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] ) ] . obo:OBI_0003464 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific survival after pathogen challenge" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring T cell epitope specific protection from pathogen challenge using survival." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "survival from pathogen challenge|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific survival after pathogen challenge" ; rdfs:subClassOf obo:OBI_0003457, obo:OBI_0003460 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003457 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000712 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003414 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] ) ] . obo:OBI_0003465 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific protection from pathogen challenge" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring B cell epitope specific protection from pathogen challenge." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "protection from pathogen challenge|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific protection from pathogen challenge" ; rdfs:subClassOf obo:OBI_0001179, obo:OBI_0001710 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001179 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000712 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003414 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] ) ] . obo:OBI_0003466 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific protection from tumor challenge" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring B cell epitope specific protection from tumor challenge." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "protection from tumor challenge|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific protection from tumor challenge" ; rdfs:subClassOf obo:OBI_0001183, obo:OBI_0001710 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001183 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003414 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003455 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] ) ] . obo:OBI_0003467 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific protection from other challenge" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring B cell epitope specific protection from a challenge other than pathogen, infection, or tumor." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "protection from other challenge|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific protection from other challenge" ; rdfs:subClassOf obo:OBI_0001710 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003414 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:complementOf [ a owl:Class ; owl:unionOf (obo:OBI_0000712 obo:OBI_0003455 ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] ) ] . obo:OBI_0003468 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific survival after pathogen challenge" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring B cell epitope specific protection from pathogen challenge using survival." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "survival from pathogen challenge|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific survival after pathogen challenge" ; rdfs:subClassOf obo:OBI_0003457, obo:OBI_0003465 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003457 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000712 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003414 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] ) ] . obo:OBI_0003469 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific survival after tumor challenge" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring B cell epitope specific protection from tumor challenge using survival." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "survival from tumor challenge|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific survival after tumor challenge" ; rdfs:subClassOf obo:OBI_0003459, obo:OBI_0003466 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003459 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003414 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003455 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] ) ] . obo:OBI_0003470 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific protection from pathogen challenge resulting from the adoptive transfer of epitope specific T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring a T cell epitope specific protection from a pathogen challenge after adoptive transfer of epitope specific antibodies or B cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "protection from pathogen challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific protection from pathogen challenge resulting from the adoptive transfer of epitope specific T cells" ; rdfs:subClassOf obo:OBI_0001179, obo:OBI_0002637 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001179 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000712 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] ) ] . obo:OBI_0003471 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific pathogen protection from challenge resulting from the adoptive transfer of epitope specific T cells based on survival" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring T cell epitope specific protection from pathogen challenge resulting from the adoptive transfer of epitope specific T cells using survival." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "survival after pathogen challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific pathogen protection from challenge resulting from the adoptive transfer of epitope specific T cells based on survival" ; rdfs:subClassOf obo:OBI_0003464, obo:OBI_0003470, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000712 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001174 obo:OBI_0003414 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] . obo:OBI_0003472 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring a T cell epitope specific protection from a tumor challenge after adoptive transfer of epitope specific T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "protection from tumor challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific T cells" ; rdfs:subClassOf obo:OBI_0001183, obo:OBI_0002637 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001183 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003455 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] ) ] . obo:OBI_0003473 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific T cells based on survival" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring T cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific T cells using survival." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "survival after tumor challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific T cells based on survival" ; rdfs:subClassOf obo:OBI_0003463, obo:OBI_0003472, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003455 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001174 obo:OBI_0003414 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] . obo:OBI_0003474 obo:IAO_0000111 "in vivo assay measuring T cell epitope specific protection from other challenge resulting from the adoptive transfer of epitope specific T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring a T cell epitope specific protection from other challenge after adoptive transfer of epitope specific T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "protection from other challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring T cell epitope specific protection from other challenge resulting from the adoptive transfer of epitope specific T cells" ; rdfs:subClassOf obo:OBI_0002637 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:complementOf [ a owl:Class ; owl:unionOf (obo:OBI_0000712 obo:OBI_0003455 ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ] ] ) ] . obo:OBI_0003475 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific protection from pathogen challenge resulting from the adoptive transfer of epitope specific antibodies or B cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring a B cell epitope specific protection from a pathogen challenge after adoptive transfer of epitope specific antibodies or B cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "protection from pathogen challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific protection from pathogen challenge resulting from the adoptive transfer of epitope specific antibodies or B cells" ; rdfs:subClassOf obo:OBI_0001179, obo:OBI_0002638 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001179 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000712 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] ) ] . obo:OBI_0003476 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific pathogen protection from challenge resulting from the adoptive transfer of epitope specific antibodies or B cells based on survival" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring B cell epitope specific protection from pathogen challenge resulting from the adoptive transfer of epitope specific antibodies or B cells using survival." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "survival after pathogen challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific pathogen protection from challenge resulting from the adoptive transfer of epitope specific antibodies or B cells based on survival" ; rdfs:subClassOf obo:OBI_0003468, obo:OBI_0003475, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000712 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001174 obo:OBI_0003414 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] . obo:OBI_0003477 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific antibodies or B cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring a B cell epitope specific protection from a tumor challenge after adoptive transfer of epitope specific antibodies or B cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "protection from tumor challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific antibodies or B cells" ; rdfs:subClassOf obo:OBI_0001183, obo:OBI_0002638 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001183 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003455 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] ) ] . obo:OBI_0003478 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific antibodies or B cells based on survival" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring B cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific antibodies or B cells using survival." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "survival after tumor challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific antibodies or B cells based on survival" ; rdfs:subClassOf obo:OBI_0003469, obo:OBI_0003477, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003455 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001174 obo:OBI_0003414 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] . obo:OBI_0003479 obo:IAO_0000111 "in vivo assay measuring B cell epitope specific protection from other challenge resulting from the adoptive transfer of epitope specific antibodies or B cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An in vivo assay measuring a B cell epitope specific protection from other challenge after adoptive transfer of epitope specific antibodies or B cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "protection from other challenge after adoptive transfer|in vivo assay" ; a owl:Class ; rdfs:label "in vivo assay measuring B cell epitope specific protection from other challenge resulting from the adoptive transfer of epitope specific antibodies or B cells" ; rdfs:subClassOf obo:OBI_0002638 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0001174 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:complementOf [ a owl:Class ; owl:unionOf (obo:OBI_0000712 obo:OBI_0003455 ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NCBITaxon_33208 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ] ] ) ] . obo:OBI_0003480 obo:IAO_0000111 "Gram stain assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that identifies bacteria based on the differential retention of a crystal violet-iodine complex within the cell wall." ; obo:IAO_0000116 "Gram-positive bacteria retain the violet stain whereas gram-negative bacteria do not." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "American Heritage Medical Dictionary", "NCI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1603" ; a owl:Class ; rdfs:label "Gram stain assay" ; rdfs:subClassOf obo:OBI_0003498 . obo:OBI_0003481 obo:IAO_0000111 "cow-baited arthropod trap" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A resting arthropod trap that consists of a tent inside which an adult cow is tethered to the ground, in order to attract arthropods and collect those that rest on the interior walls of the tent." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "Sarah Kelly" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1602" ; a owl:Class ; rdfs:label "cow-baited arthropod trap" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:OBI_0002913 ] . obo:OBI_0003482 obo:IAO_0000111 "lymph specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from a portion of lymph collected from an organism." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "lymph specimen" ; rdfs:subClassOf obo:OBI_0001479, [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002391 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] . obo:OBI_0003483 obo:IAO_0000111 "digestive tract specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from part of a digestive tract." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; a owl:Class ; rdfs:label "digestive tract specimen" ; rdfs:subClassOf obo:OBI_0001479, [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] . obo:OBI_0003484 obo:IAO_0000111 "assay measuring epitope specific interleukin-25 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope specific cytokine production assay that detects interleukin-25 production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-25 release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific interleukin-25 production by T cells" ; rdfs:subClassOf obo:OBI_1110129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032629 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0003485 obo:IAO_0000111 "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-25 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-25 production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-25 release|RNA/DNA detection" ; a owl:Class ; rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-25 production by T cells" ; rdfs:subClassOf obo:OBI_0000874, obo:OBI_0003484 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000874 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032629 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0003486 obo:IAO_0000111 "intracellular cytokine staining assay measuring epitope specific interleukin-25 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects interleukin-25 production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-25 release|ICS" ; a owl:Class ; rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-25 production by T cells" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0003484 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032629 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0003487 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-25 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-25 production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-25 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-25 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0003484 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032629 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0003488 obo:IAO_0000111 "cell culture analyte detection bioassay measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A reporter cell line analyte detection bioassay that detects tumor necrosis factor superfamily cytokine production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TNF release|bioassay" ; a owl:Class ; rdfs:label "cell culture analyte detection bioassay measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ; rdfs:subClassOf obo:OBI_0000904, obo:OBI_0001400 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000904 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071706 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_0003489 obo:IAO_0000111 "Scrub Typhus Detect IgM ELISA kit" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay kit that is manufactured by InBios International to use ELISA to test for IgM antibodies for Orientia tsutsugamushi strains Karp, Kato, Gilliam, and TA 716, with a protein microarray that has a 96-well plate and the 56-kDa type-specific antigen." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "https://inbios.com/scrub-typhus-detecttm-igm-elisa-kit-intl/" ; a owl:Class ; rdfs:label "Scrub Typhus Detect IgM ELISA kit" ; rdfs:subClassOf obo:OBI_0003369, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:OBI_0003541 ], [ a owl:Restriction ; owl:hasValue obo:OBI_0003497 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003490 obo:IAO_0000111 "Panbio Dengue IgM capture ELISA kit" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay kit that is manufactured by Abbott to test for IgM antibodies for Dengue with a two-plate protein microarray. One plate contains stabilized Dengue viruses 1 through 4, and the other plate contains anti-human IgM antibody." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; a owl:Class ; rdfs:label "Panbio Dengue IgM capture ELISA kit" ; rdfs:subClassOf obo:OBI_0003369, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:OBI_0003542 ], [ a owl:Restriction ; owl:hasValue obo:OBI_0003495 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003491 obo:IAO_0000111 "Panbio Dengue Early ELISA kit" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay kit that is manufactured by Abbott to detect the NS1 Dengue viral protein with a protein microarray and an anti-NS1 monoclonal antibody." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; a owl:Class ; rdfs:label "Panbio Dengue Early ELISA kit" ; rdfs:subClassOf obo:OBI_0003369, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:OBI_0003543 ], [ a owl:Restriction ; owl:hasValue obo:OBI_0003495 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003492 obo:IAO_0000111 "SD Bioline Chikungunya IgM RDT kit" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A device manufactured by Abbott for rapid detection of human IgM antibodies for Chikungunya virus in blood, using analytical chromatography." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "https://www.indiamart.com/proddetail/abbott-sd-bioline-chikungunya-igm-test-kit-12908515588.html" ; a owl:Class ; rdfs:label "SD Bioline Chikungunya IgM RDT kit" ; rdfs:subClassOf obo:OBI_0003369, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:OBI_0003544 ], [ a owl:Restriction ; owl:hasValue obo:OBI_0003495 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003493 obo:IAO_0000111 "SD Bioline Chikungunya IgM capture ELISA kit" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay kit that is manufactured by Abbott to detect human IgM antibodies for Chikungunya with a protein microarray and ELISA." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; a owl:Class ; rdfs:label "SD Bioline Chikungunya IgM capture ELISA kit" ; rdfs:subClassOf obo:OBI_0003369, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:OBI_0003545 ], [ a owl:Restriction ; owl:hasValue obo:OBI_0003495 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003494 obo:IAO_0000111 "Advantage Chikungunya IgM Card kit" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay kit that is manufactured by J. Mitra to detect human IgM antibodies for Chikungunya virus with a protein microarray and double-antigen sandwich ELISA." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; a owl:Class ; rdfs:label "Advantage Chikungunya IgM Card kit" ; rdfs:subClassOf obo:OBI_0003369, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:OBI_0003546 ], [ a owl:Restriction ; owl:hasValue obo:OBI_0003496 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003495 obo:IAO_0000111 "Abbott" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A manufacturer of rapid point-of-care assay devices." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "WEB:https://www.globalpointofcare.abbott/en/about.html" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1456" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "Abbott" . obo:OBI_0003496 obo:IAO_0000111 "J. Mitra" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A manufacturer of in vitro diagnostic assay kits in India." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "WEB:https://jmitra.co.in/about-us/" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1456" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "J. Mitra" . obo:OBI_0003497 obo:IAO_0000111 "InBios" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A manufacturer that specializes in in vitro diagnostic devices designed to test for infectious diseases." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "WEB:https://inbios.com/about/" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1456" ; a obo:OBI_0000835, owl:NamedIndividual ; rdfs:label "InBios" . obo:OBI_0003498 obo:IAO_0000111 "organism detection assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that detects a type of organism and/or the quantity of individuals of a type of organism." ; obo:IAO_0000116 "This term is a generalized version of the term previously known as 'organism identification assay', to include classification other than species and to include quantities as outputs." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1633" ; a owl:Class ; rdfs:label "organism detection assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100051 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0100026 ] ] . obo:OBI_0003501 obo:IAO_0000111 "functional assessment of individual" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A physical examination of an organism's ability to perform functional activities." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "functional assessment of individual" ; rdfs:subClassOf obo:OBI_0002441 . obo:OBI_0003502 obo:IAO_0000111 "facial atrophy assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An observational assessment of the loss of facial muscle tissue due to inactivity or disease." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "facial atrophy assessment" ; rdfs:subClassOf obo:OBI_0003536, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0001577 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060185 ] ] . obo:OBI_0003503 obo:IAO_0000111 "tongue atrophy assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An observational assessment of the loss of muscle tissue related to tongue movement due to inactivity or disease." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "tongue atrophy assessment" ; rdfs:subClassOf obo:OBI_0003536, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0001723 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060185 ] ] . obo:OBI_0003504 obo:IAO_0000111 "forced cough assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assessment of an individual's ability to cough forcefully." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "forced cough assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0001103 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060185 ] ] . obo:OBI_0003505 obo:IAO_0000111 "speech test assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assessment of an individual's ability to understandably repeat spoken sentences." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "speech test assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0000165 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060185 ] ] . obo:OBI_0003506 obo:IAO_0000111 "finger to finger assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assessment of an individual's ability to touch index fingers together in front of the sternum without oscillation for a specified duration of time" ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "finger to finger assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0002389 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060181 ] ] . obo:OBI_0003507 obo:IAO_0000111 "nose to finger assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assessment of an individual's ability to touch their own nose and then touch an examiners finger in front of them and then touch their own nose once more." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "nose to finger assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0001460 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060181 ] ] . obo:OBI_0003508 obo:IAO_0000111 "dysmetria assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assessment of an individual's ability to accurately touch a moving target with their finger and then touch their own chin a number of times in a row." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "dysmetria assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0001460 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060181 ] ] . obo:OBI_0003509 obo:IAO_0000111 "rapid alternating hands assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assessment of an individual's ability to alternate the forearm between pronation and suppination as quickly as possible during a specified duration of time" ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "rapid alternating hands assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0002386 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060181 ] ] . obo:OBI_0003510 obo:IAO_0000111 "finger taps assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assessment of an individual's ability to touch their finger-tip to thumb as many times as possible during a specified duration of time." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "finger taps assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0002389 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060181 ] ] . obo:OBI_0003511 obo:IAO_0000111 "heel along shin assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assessment of an individual's ability to slide their heel back and forth along their contralateral tibia from the patella to the ankle with the contralateral leg extended." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "heel along shin assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0000978 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060182 ] ] . obo:OBI_0003512 obo:IAO_0000111 "heel to shin assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assessment of an individual's ability to tap their heel to the midpoint of the contralateral shin a number of times." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "heel to shin assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0000978 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060182 ] ] . obo:OBI_0003513 obo:IAO_0000111 "muscle atrophy assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An observational assesment of an individual's muscle tissue loss due to inactivity or disease." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "muscle atrophy assessment" ; rdfs:subClassOf obo:OBI_0003536, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0000010 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060186 ] ] . obo:OBI_0003514 obo:IAO_0000111 "muscle weakness assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assessment of an individual's ability to perform muscle movement to overcome gravity or physical resistence." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "muscle weakness assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0000010 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060186 ] ] . obo:OBI_0003515 obo:IAO_0000111 "vibratory sense assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assessment of an individual's ability to sense vibration." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "vibratory sense assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0000010 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060186 ] ] . obo:OBI_0003516 obo:IAO_0000111 "position sense assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assessment of an individual's ability to sense the position of a finger or toe that has been manipulated by minimal random movements." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "position sense assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0000010 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060186 ] ] . obo:OBI_0003517 obo:IAO_0000111 "deep tendon reflex assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assessment of an individual's muscle contraction when a muscle is triggered by a signal from a muscle spindle in response to a stimulus applied to a specific trigger point on the body." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "deep tendon reflex assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0000010 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060186 ] ] . obo:OBI_0003518 obo:IAO_0000111 "limits of stability assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The functional assessment of an individual's ability to maintain balance, posture or upright stability." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "limits of stability assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060184 ] ] . obo:OBI_0003519 obo:IAO_0000111 "sitting posture assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A limits of stability assessment designed to assess an individual's ability to maintain unsupported posture while sitting over a given time period." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "sitting posture assessment" ; rdfs:subClassOf obo:OBI_0003518, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060184 ] ] . obo:OBI_0003520 obo:IAO_0000111 "stance feet apart assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A limits of stability assessment designed to assess an individual's ability to maintain a stable stance with feet 20 cm apart." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "stance feet apart assessment" ; rdfs:subClassOf obo:OBI_0003518, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060184 ] ] . obo:OBI_0003521 obo:IAO_0000111 "stance feet apart assessment, with eyes closed" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A limits of stability assessment designed to assess an individual's ability to maintain a stable stance with their eyes closed." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "stance feet apart assessment, with eyes closed" ; rdfs:subClassOf obo:OBI_0003518, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060184 ] ] . obo:OBI_0003522 obo:IAO_0000111 "stance feet together assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A limits of stability assessment designed to assess an individual's ability to maintain a stable stance with feet together." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "stance feet together assessment" ; rdfs:subClassOf obo:OBI_0003518, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060184 ] ] . obo:OBI_0003523 obo:IAO_0000111 "stance feet together assessment, with eyes closed" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A limits of stability assessment designed to assess an individual's ability to maintain a stable stance with feet together and eyes closed." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "stance feet together assessment, with eyes closed" ; rdfs:subClassOf obo:OBI_0003518, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060184 ] ] . obo:OBI_0003524 obo:IAO_0000111 "tandem stance assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A limits of stability assessment designed to assess an individual's ability to maintain a stable stance with feet in tandem placement." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "tandem stance assessment" ; rdfs:subClassOf obo:OBI_0003518, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060184 ] ] . obo:OBI_0003525 obo:IAO_0000111 "stance on one foot assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A limits of stability assessment designed to assess an individual's ability to maintain a stable stance on one foot." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "stance on one foot assessment" ; rdfs:subClassOf obo:OBI_0003518, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060184 ] ] . obo:OBI_0003526 obo:IAO_0000111 "tandem walk assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A limits of stability assessment designed to assess an individual's ability to maintain balance while walking in a straight line placing steps in tandem." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "tandem walk assessment" ; rdfs:subClassOf obo:OBI_0003518, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060184 ] ] . obo:OBI_0003527 obo:IAO_0000111 "gait assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A limits of stability assessment designed to assess an individual's manner or pattern of walking." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "gait assessment" ; rdfs:subClassOf obo:OBI_0003518, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060184 ] ] . obo:OBI_0003528 obo:IAO_0000111 "bulbar assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assessment of an individual's lower cranial nerve function via proxy of facial muscle performance." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "bulbar assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060185 ] ] . obo:OBI_0003529 obo:IAO_0000111 "spontaneous speech assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assessment of an individual's ability to articulate spoken words." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "spontaneous speech assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060185 ] ] . obo:OBI_0003530 obo:IAO_0000111 "limb coordination assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assessment of an individual's ability to coordinate limb movement." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "limb coordination assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060180 ] ] . obo:OBI_0003531 obo:IAO_0000111 "upper limb coordination assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A limb coordination assessment designed to assess an individual's ability to coordinate upper limb movement." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "upper limb coordination assessment" ; rdfs:subClassOf obo:OBI_0003530, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060181 ] ] . obo:OBI_0003532 obo:IAO_0000111 "lower limb coordination assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A limb coordination assessment designed to assess an individual's ability to coordinate lower limb movement." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "lower limb coordination assessment" ; rdfs:subClassOf obo:OBI_0003530, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060182 ] ] . obo:OBI_0003533 obo:IAO_0000111 "nervous system functionality assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assesment of an individual's nerve performance. Specifically the nerves connecting the sensory and motor structures with the central nervous system." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "nervous system functionality assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060186 ] ] . obo:OBI_0003534 obo:IAO_0000111 "upright stability assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A functional assessment of an individual's ability to maintain upright body posture." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "upright stability assessment" ; rdfs:subClassOf obo:OBI_0003501, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060184 ] ] . obo:OBI_0003535 obo:IAO_0000111 "deep tendon reflex assessment of the knee joint" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A deep tendon reflex assessment of an individual's reaction to stimulus applied to a knee joint." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "deep tendon reflex assessment of the knee joint" ; rdfs:subClassOf obo:OBI_0003517, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0001485 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060187 ] ] . obo:OBI_0003536 obo:IAO_0000111 "observational assessment of individual" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A physical examination of an organism through visual assesment." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "observational assessment of individual" ; rdfs:subClassOf obo:OBI_0002441 . obo:OBI_0003537 obo:IAO_0000111 "deep tendon reflex assessment of the ankle joint" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A deep tendon reflex assessment of an individual's reaction to stimulus applied to an ankle joint." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "deep tendon reflex assessment of the ankle joint" ; rdfs:subClassOf obo:OBI_0003517, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0001488 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060188 ] ] . obo:OBI_0003538 obo:IAO_0000111 "deep tendon reflex assessment of the tendon of biceps brachii" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A deep tendon reflex assessment of an individual's reaction to stimulus applied to a tendon of biceps brachii." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "deep tendon reflex assessment of the tendon of biceps brachii" ; rdfs:subClassOf obo:OBI_0003517, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0008188 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060189 ] ] . obo:OBI_0003539 obo:IAO_0000111 "deep tendon reflex assessment of the brachioradialis" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A deep tendon reflex assessment of an individual's reaction to stimulus applied to a brachioradialis." ; obo:IAO_0000117 "Daniel Olson, ORCID: 0000-0002-8134-1207" ; obo:IAO_0000119 "Critical Path Institute" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1637" ; a owl:Class ; rdfs:label "deep tendon reflex assessment of the brachioradialis" ; rdfs:subClassOf obo:OBI_0003517, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:UBERON_0011011 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000221 ; owl:someValuesFrom obo:OBA_2060190 ] ] . obo:OBI_0003540 obo:IAO_0000111 "tandem mass spectrometry assay" ; obo:IAO_0000112 "A precursor ion is selected in the first stage, allowed to fragment and then all resultant masses are scanned in the second mass analyzer and detected in the detector that is positioned after the second mass analyzer. This experiment is commonly performed to identify transitions used for quantification by tandem MS." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A mass spectrometry assay that uses two or more analyzers separated by a region in which ions can be induced to fragment by transfer of energy (frequently by collision with other molecules)." ; obo:IAO_0000116 "Discussed on the OBI developer call 2022-03-07: 'tandem mass spectrometry' OBI:0200198 is under 'data transformation' but is actually defined like an assay. Moving OBI:0200198 from 'data transformation' to 'assay' is a major logical change, so the OBI development team supports obsoleting 'tandem mass spectrometry' OBI:0200198 and replacing it with ‘tandem mass spectrometry assay’ OBI:0003540." ; obo:IAO_0000117 "Hector Guzman-Orozco, ORCID:0000-0003-3430-8997" ; obo:IAO_0000119 "http://purl.obolibrary.org/obo/OBI_0200198" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1506" ; a owl:Class ; rdfs:label "tandem mass spectrometry assay" ; rdfs:subClassOf obo:OBI_0000470 . obo:OBI_0003541 obo:IAO_0000111 "ELISA measuring Orientia tsutsugamushi IgM antibody" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects the IgM antibody that binds Orientia tsutsugamushi." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1456" ; a owl:Class ; rdfs:label "ELISA measuring Orientia tsutsugamushi IgM antibody" ; rdfs:subClassOf obo:OBI_0000661, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071753 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_784 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071753 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_784 ] ) ] ] ) ] . obo:OBI_0003542 obo:IAO_0000111 "microarray assay measuring Dengue IgM antibody" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A microarray assay that detects the IgM antibody that binds Dengue." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1456" ; a owl:Class ; rdfs:label "microarray assay measuring Dengue IgM antibody" ; rdfs:subClassOf obo:OBI_0001985, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071753 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_12637 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071753 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_12637 ] ) ] ] ) ] . obo:OBI_0003543 obo:IAO_0000111 "microarray assay measuring NS1" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A microarray assay that detects NS1." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1456" ; a owl:Class ; rdfs:label "microarray assay measuring NS1" ; rdfs:subClassOf obo:OBI_0001985, obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000036824 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000036824 ] ) ] . obo:OBI_0003544 obo:IAO_0000111 "analytical chromatography measuring Chikungunya IgM antibody" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Analytical chromatography that detects the IgM antibody that binds Chikungunya." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1456" ; a owl:Class ; rdfs:label "analytical chromatography measuring Chikungunya IgM antibody" ; rdfs:subClassOf obo:OBI_0001630, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071753 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_37124 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071753 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_37124 ] ) ] ] ) ] . obo:OBI_0003545 obo:IAO_0000111 "ELISA measuring Chikungunya IgM antibody" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects the IgM antibody that binds Chikungunya." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1456" ; a owl:Class ; rdfs:label "ELISA measuring Chikungunya IgM antibody" ; rdfs:subClassOf obo:OBI_0000661, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071753 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_37124 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071753 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_37124 ] ) ] ] ) ] . obo:OBI_0003546 obo:IAO_0000111 "microarray ELISA measuring Chikungunya IgM antibody" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that uses a microarray as the solid support and detects the IgM antibody that binds Chikungunya." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1456" ; a owl:Class ; rdfs:label "microarray ELISA measuring Chikungunya IgM antibody" ; rdfs:subClassOf obo:OBI_0000661, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071753 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_37124 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071753 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_37124 ] ) ] ] ) ] . obo:OBI_0003547 obo:IAO_0000111 "liquid chromatography" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A preparative chromatography in which material components are separated in a liquid solution." ; obo:IAO_0000117 "Hector Guzman-Orozco" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1685" ; a owl:Class ; rdfs:label "liquid chromatography" ; rdfs:subClassOf obo:OBI_0600046 . obo:OBI_0003548 obo:IAO_0000111 "upper limit of detection" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A value specification that specifies the largest concentration/amount of a substance that can be quantified in an analyte assay." ; obo:IAO_0000117 "Bjoern Peters", "Hector Guzman-Orozco" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1485" ; a owl:Class ; rdfs:label "upper limit of detection" ; rdfs:subClassOf obo:OBI_0001933 . obo:OBI_0003549 obo:IAO_0000111 "lower limit of detection" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A value specification that specifies the smallest concentration/amount of a substance that can be detected in an analyte assay." ; obo:IAO_0000117 "Bjoern Peters", "Hector Guzman-Orozco" ; obo:IAO_0000119 "OBI" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1485" ; a owl:Class ; rdfs:label "lower limit of detection" ; rdfs:subClassOf obo:OBI_0001933 . obo:OBI_0003550 obo:IAO_0000111 "odor baited CDC light trap" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A CDC light trap that uses odorous gas from a human being as an attractant, by pumping it from the room where the human being sleeps into the trap." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000118 "human odour baited light trap" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1654" ; a owl:Class ; rdfs:label "odor baited CDC light trap" ; rdfs:subClassOf obo:OBI_0002926 . obo:OBI_0003551 obo:IAO_0000111 "resting clay pot trap" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A resting arthropod trap that consists of a container composed primarily of clay." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000118 "resting clay pot catch" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1651" ; a owl:Class ; rdfs:label "resting clay pot trap" ; rdfs:subClassOf obo:OBI_0002939 . obo:OBI_0003552 obo:IAO_0000111 "proximity ligation-assisted ChIP-seq" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A chromosome conformation capture assay in which proximity ligation is conducted in nuclei prior to chromatin shearing and immunoprecipitation. Immunopreciptation with an antibody that targets a transcription factor or histone modification allows for selection and enrichment of specific genomic regions for investigation of long-range chromosomal interactions." ; obo:IAO_0000117 "Hector Guzman-Orozco" ; obo:IAO_0000118 "PLAC-seq" ; obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143423/" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1145" ; a owl:Class ; rdfs:label "proximity ligation-assisted ChIP-seq" ; rdfs:subClassOf obo:OBI_0002439 . obo:OBI_0003553 obo:IAO_0000111 "intragastric administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance into the stomach of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "intragastric administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] ] . obo:OBI_0003554 obo:IAO_0000111 "intracolonic administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance into the colon of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "intracolonic administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] ] . obo:OBI_0003555 obo:IAO_0000111 "vaginal administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance into the vagina of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "vaginal administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] ] . obo:OBI_0003556 obo:IAO_0000111 "topical administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance onto the surface of the skin of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000118 "percutaneous administration", "transcutaneous administration" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "topical administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0002097 ] ) ] ] . obo:OBI_0003557 obo:IAO_0000111 "cervical administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance to the cervix of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "cervical administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0000002 ] ) ] ] . obo:OBI_0003558 obo:IAO_0000111 "conjunctival administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance to the conjunctiva of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "conjunctival administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0001811 ] ) ] ] . obo:OBI_0003559 obo:IAO_0000111 "intratracheal administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance into the trachea of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "intratracheal administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] ] . obo:OBI_0003560 obo:IAO_0000111 "intra-amniotic administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance into the amnion of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "intra-amniotic administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0000305 ] ) ] ] . obo:OBI_0003561 obo:IAO_0000111 "intra-arterial administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance into the artery of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "intra-arterial administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0001637 ] ) ] ] . obo:OBI_0003562 obo:IAO_0000111 "intracerebral administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance into the cerebrum of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "intracerebral administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0001893 ] ) ] ] . obo:OBI_0003563 obo:IAO_0000111 "intracranial administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance into the cranium of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "intracranial administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0003128 ] ) ] ] . obo:OBI_0003564 obo:IAO_0000111 "intraepidermal administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance into the epidermis of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "intraepidermal administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0001003 ] ) ] ] . obo:OBI_0003565 obo:IAO_0000111 "intralymphatic administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance into the lymphatic system of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "intralymphatic administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002465 ] ] ) ] ] . obo:OBI_0003566 obo:IAO_0000111 "lymph node administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An intralymphatic administration in which the substance is administered into a lymph node." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "lymph node administration" ; rdfs:subClassOf obo:OBI_0003565, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0000029 ] ) ] ] . obo:OBI_0003567 obo:IAO_0000111 "urethral administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance into the urethra of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "urethral administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] ] . obo:OBI_0003568 obo:IAO_0000111 "skin scarification administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An intraepidermal administration in which the skin is scratched before the substance is administered to the skin." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "skin scarification administration" ; rdfs:subClassOf obo:OBI_0003564, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003575 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0001003 ] ) ] ] . obo:OBI_0003569 obo:IAO_0000111 "intrauteral administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An adminstration of a substance into the uterus of an organism. " ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "intrauteral administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0000995 ] ) ] ] . obo:OBI_0003570 obo:IAO_0000111 "intracarotid administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An intra-arterial administration in which the substance is administered into the carotid artery." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000118 "i.c.", "i.c. administration" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "intracarotid administration" ; rdfs:subClassOf obo:OBI_0003561, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0001530 ] ) ] ] . obo:OBI_0003571 obo:IAO_0000111 "intraocular administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance to the eye of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "intraocular administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0000970 ] ) ] ] . obo:OBI_0003572 obo:IAO_0000111 "intraplacental administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance into the placenta of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "intraplacental administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] ] . obo:OBI_0003573 obo:IAO_0000111 "intrarectal administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance into the rectum of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "intrarectal administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0001052 ] ) ] ] . obo:OBI_0003574 obo:IAO_0000111 "intrasplenic administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance into the spleen of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "intrasplenic administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] ] . obo:OBI_0003575 obo:IAO_0000111 "scratching"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A process in which the target material entity is scraped by another material entity."@en ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000118 "abrading" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1703" ; a owl:Class ; rdfs:label "scratching"@en ; rdfs:subClassOf obo:BFO_0000015 . obo:OBI_0003576 obo:IAO_0000111 "skin of body microbiology assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that detects microorganisms in a skin of body specimen." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1680" ; a owl:Class ; rdfs:label "skin of body microbiology assay" ; rdfs:subClassOf obo:OBI_0003498, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002526 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0100026 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100026 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0002526 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000027 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0100026 ] ] . obo:OBI_0003577 obo:IAO_0000111 "skin of body microbiology datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection datum that is the specified output of a skin of body microbiology assay." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1680" ; a owl:Class ; rdfs:label "skin of body microbiology datum" ; rdfs:subClassOf obo:OBI_0003064 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003064 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003576 ] ) ] . obo:OBI_0003578 obo:IAO_0000111 "bone marrow microbiology assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that detects microorganisms in a bone marrow specimen." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1680" ; a owl:Class ; rdfs:label "bone marrow microbiology assay" ; rdfs:subClassOf obo:OBI_0003498, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002512 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002512 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0100026 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100026 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0002512 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000027 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0100026 ] ] . obo:OBI_0003579 obo:IAO_0000111 "bone marrow microbiology datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection datum that is the specified output of a bone marrow microbiology assay." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1680" ; a owl:Class ; rdfs:label "bone marrow microbiology datum" ; rdfs:subClassOf obo:OBI_0003064 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003064 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003578 ] ) ] . obo:OBI_0003580 obo:IAO_0000111 "nasal aspirate microbiology assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection assay that detects microorganisms in a nasal aspirate specimen." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1680" ; a owl:Class ; rdfs:label "nasal aspirate microbiology assay" ; rdfs:subClassOf obo:OBI_0003498, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002780 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002780 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0100026 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100026 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0002780 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000027 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0100026 ] ] . obo:OBI_0003581 obo:IAO_0000111 "nasal aspirate microbiology datum" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism detection datum that is the specified output of a nasal aspirate microbiology assay." ; obo:IAO_0000117 "John Judkins ORCID:0000-0001-6595-0902" ; obo:IAO_0000119 "VEuPathDB" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1680" ; a owl:Class ; rdfs:label "nasal aspirate microbiology datum" ; rdfs:subClassOf obo:OBI_0003064 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003064 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003580 ] ) ] . obo:OBI_0003582 obo:IAO_0000111 "cell proliferation assay using carboxyfluorescein succinimidyl ester staining" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cell proliferation assay that uses carboxyfluorescein succinimidyl ester staining to detect cell division." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1007" ; a owl:Class ; rdfs:label "cell proliferation assay using carboxyfluorescein succinimidyl ester staining" ; rdfs:subClassOf obo:OBI_0000891, obo:OBI_0002106 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003585 ] ) ] . obo:OBI_0003583 obo:IAO_0000111 "cell viability assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cytometry assay which measures the number of living cells in a population." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1007" ; a owl:Class ; rdfs:label "cell viability assay" ; rdfs:subClassOf obo:OBI_0001977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001977 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PATO_0000169 ] ] ) ] . obo:OBI_0003584 obo:IAO_0000111 "cell viability assay using Annexin V staining" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cell viability assay that uses Annexin V staining to detect apoptotic cells." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1007" ; a owl:Class ; rdfs:label "cell viability assay using Annexin V staining" ; rdfs:subClassOf obo:OBI_0003583 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003583 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0003586 ] ) ] . obo:OBI_0003585 obo:IAO_0000111 "carboxyfluorescein succinimidyl ester staining"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Staining using carboxyfluorescein succinimidyl ester." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1007" ; a owl:Class ; rdfs:label "carboxyfluorescein succinimidyl ester staining"@en ; rdfs:subClassOf obo:OBI_0302887 . obo:OBI_0003586 obo:IAO_0000111 "Annexin V staining"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Staining using Annexin V to detect apoptotic cells." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1007" ; a owl:Class ; rdfs:label "Annexin V staining"@en ; rdfs:subClassOf obo:OBI_0302887 . obo:OBI_0003587 obo:IAO_0000111 "cell culture assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An assay that has cell culture as an input." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; a owl:Class ; rdfs:label "cell culture assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100060 ] ) ] . obo:OBI_0003589 obo:IAO_0000111 "serum anti-Epstein-Barr virus antibody level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An antigen specific antibodies assay that is meant to detect antibodies that bind to Epstein-Barr virus (EBV) antigens in a serum sample." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000118 "EBV" ; a owl:Class ; rdfs:label "serum anti-Epstein-Barr virus antibody level assay" ; rdfs:subClassOf obo:OBI_0002145 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0002145 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0100017 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100017 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_10376 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:OBI_0001637 ; owl:someValuesFrom obo:NCBITaxon_10376 ] ) ] ] ) ] ) ] . obo:OBI_0003590 obo:IAO_0000111 "serum anti-cytomegalovirus antibody level assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A CMV antibody assay that has serum as an input." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000118 "CMV" ; a owl:Class ; rdfs:label "serum anti-cytomegalovirus antibody level assay" ; rdfs:subClassOf obo:OBI_0002154 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0002154 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0100017 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100017 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] ) ] . obo:OBI_0003591 obo:IAO_0000111 "chronic allograft damage index score"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A clinical data item that quantifies the degree of tissue damage in biopsies taken from transplanted kidneys." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000118 "CADI" ; a owl:Class ; rdfs:label "chronic allograft damage index score"@en ; rdfs:subClassOf obo:OGMS_0000123, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0100051 ] . obo:OBI_0003592 obo:IAO_0000111 "sequential organ failure assessment score"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical data item that quantifies the degree of function of a critically ill patient's organs." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000118 "SOFA score" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/SOFA_score" ; a owl:Class ; rdfs:label "sequential organ failure assessment score"@en ; rdfs:subClassOf obo:OGMS_0000123 . obo:OBI_0003593 obo:IAO_0000111 "physician's global assessment of disease activity"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A clinical data item that quantifies a physician's judgement of the overall activity of some specific disease in a patient." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000118 "MD global, PGA" ; a owl:Class ; rdfs:label "physician's global assessment of disease activity"@en ; rdfs:subClassOf obo:OGMS_0000123, [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OGMS_0000063 ] . obo:OBI_0003594 obo:IAO_0000111 "human leukocyte antigen mismatch count"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A genetic characteristics information that is about the number of dissimilarities in the human leukocyte antigen gene complexes of two humans." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000118 "HLA mismatch count, HLA mismatch" ; a owl:Class ; rdfs:label "human leukocyte antigen mismatch count"@en ; rdfs:subClassOf obo:OBI_0001404 . obo:OBI_0003595 obo:IAO_0000111 "nasal lavage fluid" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A specimen collected through nasal cavity lavage that contains the reagents used to for the lavage process, organisms, cells, cellular secretions, and other biomaterials present in the nasal cavity space." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; a owl:Class ; rdfs:label "nasal lavage fluid" ; rdfs:subClassOf obo:OBI_0100051, [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ], [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0001826 ] ) ] ] ) ] . obo:OBI_0003598 obo:IAO_0000111 "single cell B cell receptor repertoire sequencing assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A B cell receptor repertoire sequencing assay that determines the sequence of DNA or RNA molecules that encode the repertoire of B cell receptors that can be traced to a single cell of origin." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000118 "single-cell BCR assay" ; a owl:Class ; rdfs:label "single cell B cell receptor repertoire sequencing assay" ; rdfs:subClassOf obo:OBI_0002991, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001010 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001010 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0003599 obo:IAO_0000111 "single cell T cell receptor repertoire sequencing assay" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A T cell receptor repertoire sequencing assay that determines the sequence of DNA or RNA molecules that encode the repertoire of T cell receptors that can be traced to a single cell of origin." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000118 "single-cell TCR assay" ; a owl:Class ; rdfs:label "single cell T cell receptor repertoire sequencing assay" ; rdfs:subClassOf obo:OBI_0002990, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001010 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001010 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] . obo:OBI_0003600 obo:IAO_0000111 "hypertension grade" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A categorical value specification that indicates the severity of hypertension." ; obo:IAO_0000117 "Bjoern Peters", "Randi Vita", "Sebastian Duesing" ; a owl:Class ; rdfs:label "hypertension grade" ; rdfs:subClassOf obo:OBI_0001930 . obo:OBI_0003601 obo:IAO_0000111 "quartz crystal microbalance assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures the change in frequency of a quartz crystal resonator resulting from the addition or removal of a small mass of a ligand specifically binding at the surface of the resonator." ; obo:IAO_0000117 "Bjoern Peters", "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000118 "QCM" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/23504432", "https://en.wikipedia.org/wiki/Quartz_crystal_microbalance" ; a owl:Class ; rdfs:label "quartz crystal microbalance assay" ; rdfs:subClassOf obo:OBI_0000070 . obo:OBI_0003602 obo:IAO_0000111 "quartz crystal microbalance measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A quartz crystal microbalance assay that measures the dissociation constant [KD] of an antigen binding with an antibody." ; obo:IAO_0000117 "Bjoern Peters", "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000118 "QCM measuring KD" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "dissociation constant KD|quartz crystal microbalance|nM" ; a owl:Class ; rdfs:label "quartz crystal microbalance assay measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ; rdfs:subClassOf obo:OBI_0001708, obo:OBI_0003601, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001536 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001702 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:hasValue obo:UO_0000065 ; owl:onProperty obo:IAO_0000039 ] ] . obo:OBI_0003603 obo:IAO_0000111 "intratumoral administration" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An administration of a substance into a tumor of an organism." ; obo:IAO_0000117 "Sebastian Duesing" ; a owl:Class ; rdfs:label "intratumoral administration" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:HP_0002664 ] ) ] ] . obo:OBI_0003604 obo:IAO_0000111 "multiplexed error-robust fluorescence in situ hybridization assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A fluorescence in-situ hybridization assay that uses combinatorial FISH labeling with error resistant encoding schemes for highly multiplexed single-molecule imaging." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000118 "MERFISH" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Fluorescence_in_situ_hybridization#MERFISH" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1724" ; obo:IAO_0000234 "Brain Image Library" ; a owl:Class ; rdfs:label "multiplexed error-robust fluorescence in situ hybridization assay" ; rdfs:subClassOf obo:OBI_0003094 . obo:OBI_0003605 obo:IAO_0000111 "single molecule fluorescence in situ hybridization" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A fluorescence in-situ hybridization assay that detects single RNA molecules in fixed cells, allowing for both the quantification and localization at the single-cell level and single-molecule resolution." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000118 "smFISH" ; obo:IAO_0000119 "https://doi.org/10.21769/BioProtoc.3070" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1725" ; obo:IAO_0000234 "Brain Image Library" ; a owl:Class ; rdfs:label "single molecule fluorescence in situ hybridization" ; rdfs:subClassOf obo:OBI_0003094 . obo:OBI_0003606 obo:IAO_0000111 "Illumina NextSeq 1000" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencer which is manufactured by the Illumina corporation using sequence-by-synthesis chemistry that fits on a benchtop and uses P1 and P2 flow cells." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000118 "NextSeq 1000" ; obo:IAO_0000119 "https://www.illumina.com/systems/sequencing-platforms/nextseq-1000-2000.html" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1711" ; obo:IAO_0000234 "GENEPIO" ; a owl:Class ; rdfs:label "Illumina NextSeq 1000" ; rdfs:subClassOf obo:OBI_0400103, [ a owl:Restriction ; owl:hasValue obo:OBI_0000759 ; owl:onProperty obo:OBI_0000304 ] . obo:OBI_0003607 obo:IAO_0000111 "disease causation objective"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An objective specification that is fulfilled by causing a disease in a particular organism."@en ; obo:IAO_0000117 "Sebastian Duesing" ; a owl:Class ; rdfs:label "disease causation objective"@en ; rdfs:subClassOf obo:IAO_0000005 . obo:OBI_0003608 obo:IAO_0000111 "disease severity reduction objective"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An objective specification that is fulfilled by reducing the severity of a disease in a particular organism." ; obo:IAO_0000117 "Sebastian Duesing" ; a owl:Class ; rdfs:label "disease severity reduction objective"@en ; rdfs:subClassOf obo:IAO_0000005 . obo:OBI_0003609 obo:IAO_0000111 "disease prevention objective"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An objective specification that is fulfilled by preventing the development of a disease in a particular organism." ; obo:IAO_0000117 "Sebastian Duesing" ; a owl:Class ; rdfs:label "disease prevention objective"@en ; rdfs:subClassOf obo:IAO_0000005 . obo:OBI_0003610 obo:IAO_0000111 "reactant role"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A role borne by a biological or chemical entity that participates or has molecular components that participate in a chemical reaction."@en ; obo:IAO_0000117 "Sebastian Duesing" ; a owl:Class ; rdfs:label "reactant role"@en ; rdfs:subClassOf obo:BFO_0000023 . obo:OBI_0003611 obo:IAO_0000111 "precursor role"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A role borne by a biological or chemical entity which serves as the core component of a chemical reaction process, upon which other reactants, like reagents or solvents, act."@en ; obo:IAO_0000117 "Cameron More", "Sebastian Duesing" ; a owl:Class ; rdfs:label "precursor role"@en ; rdfs:subClassOf obo:OBI_0003610 . obo:OBI_0003612 obo:IAO_0000111 "electron microscopy assay determining the 3D structure of a T cell epitope:MHC:TCR complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An electron-microscopy 3D molecular structure determination assay that characterizes the 3-dimensional molecular structrue of a T cell epitope:MHC:TCR complex." ; obo:IAO_0000117 "PERSON:Randi Vita, Sebastian Duesing, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "3D structure|electron microscopy" ; a owl:Class ; rdfs:label "electron microscopy assay determining the 3D structure of a T cell epitope:MHC:TCR complex" ; rdfs:subClassOf obo:OBI_0001999, obo:OBI_0003118 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003118 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001155 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0003120 ] ] ) ] . obo:OBI_0003613 obo:IAO_0000111 "electron microscopy assay determining the 3D structure of a MHC:ligand complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An electron-microscopy 3D molecular structure determination assay that characterizes the 3-dimensional molecular structrue of a MHC:ligand complex." ; obo:IAO_0000117 "PERSON:Randi Vita, Sebastian Duesing, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "3D structure|electron microscopy" ; a owl:Class ; rdfs:label "electron microscopy assay determining the 3D structure of a MHC:ligand complex" ; rdfs:subClassOf obo:OBI_0002050, obo:OBI_0003118 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003118 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001155 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0003121 ] ] ) ] . obo:OBI_0003614 obo:IAO_0000111 "disease prevalence reduction objective"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An objective specification that is fulfilled by reducing the prevalence of a disease in a population of organisms." ; obo:IAO_0000117 "Sebastian Duesing" ; a owl:Class ; rdfs:label "disease prevalence reduction objective"@en ; rdfs:subClassOf obo:IAO_0000005 . obo:OBI_0003615 obo:IAO_0000111 "antibody purification of MHC protein complex" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A purification to separate a material entity into different compositions of which one fraction contains a higher concentration of MHC protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; a owl:Class ; rdfs:label "antibody purification of MHC protein complex" ; rdfs:subClassOf obo:OBI_0001505 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001505 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042571 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:GO_0042571 ] ) ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:GO_0042611 ] ) ] . obo:OBI_0003616 obo:IAO_0000111 "antibody purification of MHC class I protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of MHC protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of MHC class I protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of MHC class I protein complex" ; rdfs:subClassOf obo:OBI_0003615 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003615 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0001355 ] ) ] . obo:OBI_0003617 obo:IAO_0000111 "antibody purification of human MHC class I protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of human MHC class I protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of human MHC class I protein complex" ; rdfs:subClassOf obo:OBI_0003635 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003616 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0001454 ] ) ] . obo:OBI_0003618 obo:IAO_0000111 "antibody purification of HLA protein complex with A2 serotype" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with A2 serotype, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of HLA protein complex with A2 serotype" ; rdfs:subClassOf obo:OBI_0003620 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003617 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0001530 ] ) ] . obo:OBI_0003619 obo:IAO_0000111 "antibody purification of HLA protein complex with A24 serotype" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with A24 serotype, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of HLA protein complex with A24 serotype" ; rdfs:subClassOf obo:OBI_0003617 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003617 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0001533 ] ) ] . obo:OBI_0003620 obo:IAO_0000111 "antibody purification of HLA protein complex with A2 serotype and/or HLA protein complex with A28 serotype" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with A2 serotype and/or HLA protein complex with A28 serotype, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of HLA protein complex with A2 serotype and/or HLA protein complex with A28 serotype" ; rdfs:subClassOf obo:OBI_0003617 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003617 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:MRO_0001530 obo:MRO_0001537 ) ] ] ) ] . obo:OBI_0003621 obo:IAO_0000111 "antibody purification of HLA protein complex with A29 serotype" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with A29 serotype, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of HLA protein complex with A29 serotype" ; rdfs:subClassOf obo:OBI_0003617 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003617 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0001538 ] ) ] . obo:OBI_0003622 obo:IAO_0000111 "antibody purification of HLA protein complex with B27 serotype" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with B27 serotype, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of HLA protein complex with B27 serotype" ; rdfs:subClassOf obo:OBI_0003617 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003617 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0001557 ] ) ] . obo:OBI_0003623 obo:IAO_0000111 "antibody purification of HLA-C protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA-C protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of HLA-C protein complex" ; rdfs:subClassOf obo:OBI_0003617 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003617 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0001149 ] ) ] . obo:OBI_0003624 obo:IAO_0000111 "antibody purification of pig MHC class I protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of pig MHC class I protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of pig MHC class I protein complex" ; rdfs:subClassOf obo:OBI_0003635 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003616 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0001465 ] ) ] . obo:OBI_0003625 obo:IAO_0000111 "antibody purification of cattle MHC class I protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of cattle MHC class I protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of cattle MHC class I protein complex" ; rdfs:subClassOf obo:OBI_0003635 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003616 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0001434 ] ) ] . obo:OBI_0003626 obo:IAO_0000111 "antibody purification of rat MHC class I protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of rat MHC class I protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of rat MHC class I protein complex" ; rdfs:subClassOf obo:OBI_0003616 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003616 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0001790 ] ) ] . obo:OBI_0003627 obo:IAO_0000111 "antibody purification of mouse MHC class I protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse MHC class I protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of mouse MHC class I protein complex" ; rdfs:subClassOf obo:OBI_0003616 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003616 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0001460 ] ) ] . obo:OBI_0003628 obo:IAO_0000111 "antibody purification of H2-Dd protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Dd protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of H2-Dd protein complex" ; rdfs:subClassOf obo:OBI_0003632 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003627 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0000967 ] ) ] . obo:OBI_0003629 obo:IAO_0000111 "antibody purification of H2-Db protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Db protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of H2-Db protein complex" ; rdfs:subClassOf obo:OBI_0003631, obo:OBI_0003633 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003627 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0000966 ] ) ] . obo:OBI_0003630 obo:IAO_0000111 "antibody purification of H2-Kd protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Kd protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of H2-Kd protein complex" ; rdfs:subClassOf obo:OBI_0003632 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003627 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0000992 ] ) ] . obo:OBI_0003631 obo:IAO_0000111 "antibody purification of H2-Ld protein complex, H2-Db protein complex, and/or H2-Dq protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Ld protein complex, H2-Db protein complex, and/or H2-Dq protein complex while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of H2-Ld protein complex, H2-Db protein complex, and/or H2-Dq protein complex" ; rdfs:subClassOf obo:OBI_0003627 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003627 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:MRO_0000966 obo:MRO_0000997 obo:MRO_0002026 ) ] ] ) ] . obo:OBI_0003632 obo:IAO_0000111 "antibody purification of H2-Dd protein complex and/or H2-Kd protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Dd protein complex and/or H2-Kd protein complex while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of H2-Dd protein complex and/or H2-Kd protein complex" ; rdfs:subClassOf obo:OBI_0003627 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003627 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:MRO_0000967 obo:MRO_0000992 ) ] ] ) ] . obo:OBI_0003633 obo:IAO_0000111 "antibody purification of mouse MHC class I protein complex with H2-b haplotype and/or mouse MHC protein complex with H2-p haplotype" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse MHC class I protein complex with H2-b haplotype and/or mouse MHC protein complex with H2-p haplotype while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of mouse MHC class I protein complex with H2-b haplotype and/or mouse MHC protein complex with H2-p haplotype" ; rdfs:subClassOf obo:OBI_0003627 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003627 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:MRO_0001498 obo:MRO_0001759 ) ] ] ) ] . obo:OBI_0003634 obo:IAO_0000111 "antibody purification of H2-Kb protein complex, H2-Ks protein complex, and/or H2-Kq protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse H2-Kb protein complex, H2-Ks protein complex, and/or H2-Kq protein complex while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of H2-Kb protein complex, H2-Ks protein complex, and/or H2-Kq protein complex" ; rdfs:subClassOf obo:OBI_0003627 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003627 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:MRO_0000991 obo:MRO_0000994 obo:MRO_0002027 ) ] ] ) ] . obo:OBI_0003635 obo:IAO_0000111 "antibody purification of pig MHC class I protein complex, cattle MHC class I protein complex, and/or human MHC class I protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of pig MHC class I protein complex, cattle MHC class I protein complex, and/or human MHC class I protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of pig MHC class I protein complex, cattle MHC class I protein complex, and/or human MHC class I protein complex" ; rdfs:subClassOf obo:OBI_0003616 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003616 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:MRO_0001434 obo:MRO_0001454 obo:MRO_0001465 ) ] ] ) ] . obo:OBI_0003636 obo:IAO_0000111 "antibody purification of MHC class II protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of MHC protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of MHC class II protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of MHC class II protein complex" ; rdfs:subClassOf obo:OBI_0003615 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003615 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0001356 ] ) ] . obo:OBI_0003637 obo:IAO_0000111 "antibody purification of cattle MHC class II protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of cattle MHC class II protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of cattle MHC class II protein complex" ; rdfs:subClassOf obo:OBI_0003636 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003636 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0001435 ] ) ] . obo:OBI_0003638 obo:IAO_0000111 "antibody purification of human MHC class II protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of human MHC class II protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of human MHC class II protein complex" ; rdfs:subClassOf obo:OBI_0003636 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003636 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0001455 ] ) ] . obo:OBI_0003639 obo:IAO_0000111 "antibody purification of HLA-DP protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of human MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA-DP protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of HLA-DP protein complex" ; rdfs:subClassOf obo:OBI_0003638 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003638 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0001167 ] ) ] . obo:OBI_0003640 obo:IAO_0000111 "antibody purification of HLA-DR protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of human MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA-DR protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of HLA-DR protein complex" ; rdfs:subClassOf obo:OBI_0003638 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003638 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0000013 ] ) ] . obo:OBI_0003641 obo:IAO_0000111 "antibody purification of HLA protein complex with DQ3 serotype" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of human MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with DQ3 serotype, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of HLA protein complex with DQ3 serotype" ; rdfs:subClassOf obo:OBI_0003638 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003638 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0001622 ] ) ] . obo:OBI_0003642 obo:IAO_0000111 "antibody purification of mouse MHC class II protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse MHC class II protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of mouse MHC class II protein complex" ; rdfs:subClassOf obo:OBI_0003646 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003636 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0001461 ] ) ] . obo:OBI_0003643 obo:IAO_0000111 "antibody purification of H2-IA protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of mouse MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-IA protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of H2-IA protein complex" ; rdfs:subClassOf obo:OBI_0003642 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003642 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0000971 ] ) ] . obo:OBI_0003644 obo:IAO_0000111 "antibody purification of H2-IAg7 protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of mouse MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-IAg7 protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of H2-IAg7 protein complex" ; rdfs:subClassOf obo:OBI_0003643 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003642 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0000975 ] ) ] . obo:OBI_0003645 obo:IAO_0000111 "antibody purification of H2-IAd protein complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of mouse MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-IAd protein complex, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of H2-IAd protein complex" ; rdfs:subClassOf obo:OBI_0003643 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003642 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:MRO_0000973 ] ) ] . obo:OBI_0003646 obo:IAO_0000111 "antibody purification of mouse MHC class II protein complex and/or rat MHC class II protein complex with RT1-A haplotype" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An antibody purification of MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse MHC class II protein complex and/or rat MHC class II protein complex with RT1-A haplotype, while others contain impurities and are not of interest." ; obo:IAO_0000117 "Randi Vita", "Sebastian Duesing" ; obo:IAO_0000119 "Randi Vita" ; a owl:Class ; rdfs:label "antibody purification of mouse MHC class II protein complex and/or rat MHC class II protein complex with RT1-A haplotype" ; rdfs:subClassOf obo:OBI_0003636 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0003636 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:MRO_0001461 obo:MRO_0001793 ) ] ] ) ] . obo:OBI_0003647 obo:IAO_0000111 "tandem mass spectrometry analysis" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000119 "A mass spectrometry analysis in which the data being analyzed is the result of a tandem mass spectrometry assay." ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1684" ; a owl:Class ; rdfs:label "tandem mass spectrometry analysis" ; rdfs:subClassOf obo:OBI_0200085 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0200085 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:IAO_0000027 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003540 ] ) ] ] ) ] . obo:OBI_0003648 obo:IAO_0000111 "liquid chromatography mass spectrometry analysis" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000119 "A mass spectrometry analysis in which the data being analyzed is the result of a liquid chromatography mass spectrometry assay." ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1684" ; a owl:Class ; rdfs:label "liquid chromatrography mass spectrometry analysis" ; rdfs:subClassOf obo:OBI_0200085 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0200085 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:IAO_0000027 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0003097 ] ) ] ] ) ] . obo:OBI_0003649 obo:IAO_0000111 "liquid chromatography tandem mass spectrometry analysis" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000119 "A mass spectrometry analysis in which the data being analyzed is the result of a liquid chromatography tandem mass spectrometry assay." ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1684" ; a owl:Class ; rdfs:label "liquid chromatography-tandem mass spectrometry analysis" ; rdfs:subClassOf obo:OBI_0003647, obo:OBI_0003648 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0200085 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:IAO_0000027 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:CHMO_0000701 ] ) ] ] ) ] . obo:OBI_0003650 obo:IAO_0000111 "Illumina Infinium MethylationEPIC v2.0 BeadChip" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An Illumina methylation BeadChip that targets 935,000 methylation sites per sample at single-nucleotide resolution." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000119 "https://www.illumina.com/products/by-type/microarray-kits/infinium-methylation-epic.html" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1665" ; a owl:Class ; rdfs:label "Illumina Infinium MethylationEPIC v2.0 BeadChip" ; rdfs:subClassOf obo:OBI_0001870 . obo:OBI_0003651 obo:IAO_0000111 "multidimensional fatigue inventory score"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A clinical data item that quantifies the severity of a person's fatigue as measured by a 20-item self-report instrument." ; obo:IAO_0000117 "Sebastian Duesing" ; obo:IAO_0000119 "https://pubmed.ncbi.nlm.nih.gov/7636775/ DOI: 10.1016/0022-3999(94)00125-o" ; a owl:Class ; rdfs:label "multidimensional fatigue inventory score"@en ; rdfs:subClassOf obo:OGMS_0000123 . obo:OBI_0005246 obo:IAO_0000111 "injection function" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "The function of a device realized when administering a substance in vivo, applied particularly to the forcible insertion of a liquid or gas by means of a syringe, pump, etc." ; obo:IAO_0000117 "PERSON: Alan Ruttenberg", "PERSON: Melanie Courtot" ; obo:IAO_0000119 "adapted from WEB: http://www.dictionary.net/injection" ; a owl:Class ; rdfs:label "injection function" ; rdfs:subClassOf obo:BFO_0000034 . obo:OBI_0100010 obo:IAO_0000111 "Epstein Barr virus transformed B cell"@en ; obo:IAO_0000112 "PMID: 8777380. Expression of thyroid peroxidase in EBV-transformed B cell lines using adenovirus.Thyroid. 1996 Feb;6(1):23-8."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A material entity which results from viral transformation process using EBV as transformation agent when applied to B-cell entity"@en ; obo:IAO_0000117 "PERSON: Susanna Sansone" ; obo:IAO_0000119 "GROUP: OBI Biomaterial Branch" ; a owl:Class ; rdfs:label "Epstein Barr virus transformed B cell"@en ; rdfs:subClassOf obo:OBI_0000047 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0600036 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:NCBITaxon_10239 ] ) ] ] [ a owl:Restriction ; owl:allValuesFrom obo:CL_0000236 ; owl:onProperty obo:RO_0001000 ] ) ] . obo:OBI_0100014 obo:IAO_0000111 "chimera"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism which contains cells or tissues with a different genotype"@en ; obo:IAO_0000117 "PERSON: Helen Parkinson"@en ; obo:IAO_0000119 "GROUP: OBI"@en ; a owl:Class ; rdfs:label "chimera"@en ; rdfs:subClassOf obo:OBI_0100026 . obo:OBI_0100015 obo:IAO_0000111 "obsolete_anatomical entity" ; obo:IAO_0000112 "Tissue, organ, system, sperm, blood or body location (arm)." ; obo:IAO_0000114 obo:IAO_0000121 ; obo:IAO_0000115 "An anatomical entity is a material entity that is part of a multicellular organism, and which is large enough so that it forms an identifiable structure in the organism. Specifically, it excludes granular parts of the organism, such as atoms, molecules, cells, which can be removed from the organism without affecting it. It is defined as the union of 'multi-tissue structure', 'body substance' and 'portion of tissue'" ; obo:IAO_0000117 "Bjoern Peters", "Philippe Rocca-Serra", "Tina Boussard" ; obo:IAO_0000119 "MO" ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:Class ; rdfs:label "obsolete_anatomical entity" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0100016 obo:IAO_0000111 "blood plasma specimen"@en ; obo:IAO_0000112 "PMID: 18217225.Sex Transm Dis. 2008 Jan;35(1):55-60. Review.Human immunodeficiency virus viral load in blood plasma and semen: review and implications of empirical findings."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a material entity which corresponds to the liquid component of blood, in which the blood cells are suspended."@en ; obo:IAO_0000116 "03/21/2010: BP, blood plasma is defined as the output of certain separation processes, so this is in the domain of OBI, not FMA."@en ; obo:IAO_0000117 "PERSON: Maura Gasparetto"@en, "PERSON: Melanie Courtot"@en, "PERSON: Philippe Rocca-Serra" ; obo:IAO_0000118 "plasma"@en ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Blood_plasma"@en ; a owl:Class ; rdfs:label "blood plasma specimen"@en ; rdfs:subClassOf obo:OBI_0000953, [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0600014 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000655 ] ) ] ] . obo:OBI_0100017 obo:IAO_0000111 "blood serum specimen"@en ; obo:IAO_0000112 "PMID: 18229666.Adv Med Sci. 2007;52 Suppl 1:204-6.Antioxidant activity of blood serum and saliva in patients with periodontal disease treated due to epilepsy."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A material entity which derives from blood and corresponds to blood plasma without fibrinogen or the other clotting factors."@en ; obo:IAO_0000117 "PERSON: Maura Gasparetto"@en, "PERSON: Melanie Courtot"@en, "PERSON: Philippe Rocca-Serra" ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Blood_plasma"@en ; a owl:Class ; rdfs:label "blood serum specimen"@en ; rdfs:subClassOf obo:OBI_0000953, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:unionOf (obo:OBI_0302885 obo:OBI_0302886 obo:OBI_0600052 ) ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000655 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] . obo:OBI_0100026 obo:IAO_0000111 "organism"@en ; obo:IAO_0000112 "animal"@en, "fungus"@en, "plant"@en, "virus"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs."@en ; obo:IAO_0000116 "10/21/09: This is a placeholder term, that should ideally be imported from the NCBI taxonomy, but the high level hierarchy there does not suit our needs (includes plasmids and 'other organisms')", """13-02-2009: OBI doesn't take position as to when an organism starts or ends being an organism - e.g. sperm, foetus. This issue is outside the scope of OBI.""" ; obo:IAO_0000117 "GROUP: OBI Biomaterial Branch" ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Organism"@en ; a owl:Class ; rdfs:label "organism"@en ; rdfs:subClassOf obo:BFO_0000040 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:NCBITaxon_10239 obo:NCBITaxon_2 obo:NCBITaxon_2157 obo:NCBITaxon_2759 ) ] . obo:OBI_0100035 obo:IAO_0000111 "obsolete_immortal cell" ; obo:IAO_0000112 "a single Hela cell" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a cell derived from a multicellular organism that has the potential to replicate indefinitely" ; obo:IAO_0000117 "PERSON: Bjoern Peters" ; obo:IAO_0000119 "GROUP: OBI Biomaterial Branch" ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:Class ; rdfs:label "obsolete_immortal cell" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0100039 obo:IAO_0000111 "obsolete_fragment derived from protein" ; obo:IAO_0000112 "the peptide with sequence SIINFEKL, which is eluted from a cell expressing hen egg lysozyme" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A material entity which is derived from a protein" ; obo:IAO_0000117 "PERSON: Bjoern Peters" ; obo:IAO_0000119 "GROUP: IEDB" ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:Class ; rdfs:label "obsolete_fragment derived from protein" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0100046 obo:IAO_0000111 "phosphate buffered saline solution"@en ; obo:IAO_0000112 "PMID: 16279733.Dent Mater J. 2005 Sep;24(3):414-21.PBS buffer solutions with different pH values can change porosity of DNA-chitosan complexes."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "Phosphate buffered saline (abbreviated PBS) is a buffer solution commonly used in biochemistry. It is a salty solution containing sodium chloride, sodium phosphate and in some preparations potassium chloride and potassium phosphate. The buffer helps to maintain a constant pH. The concentration usually matches the human body (isotonic)."@en ; obo:IAO_0000117 "PERSON: Melanie Courtot"@en, "PERSON: Philippe Rocca-Serra", "PERSON: Tina Boussard"@en ; obo:IAO_0000118 "PBS buffer"@en ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Phosphate_buffered_saline"@en ; a owl:Class ; rdfs:label "phosphate buffered saline solution"@en ; rdfs:subClassOf obo:OBI_0302729, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000576 [ a owl:Restriction ; owl:allValuesFrom obo:CHEBI_26710 ; owl:onProperty obo:OBI_0000643 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000576 [ a owl:Restriction ; owl:allValuesFrom obo:CHEBI_37586 ; owl:onProperty obo:OBI_0000643 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0302731 ] . obo:OBI_0100051 obo:IAO_0000111 "specimen"@en ; obo:IAO_0000112 "Biobanking of blood taken and stored in a freezer for potential future investigations stores specimen." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A material entity that has the specimen role."@en ; obo:IAO_0000116 "Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation." ; obo:IAO_0000117 "PERSON: James Malone", "PERSON: Philippe Rocca-Serra" ; obo:IAO_0000119 "GROUP: OBI Biomaterial Branch"@en ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "specimen"@en ; rdfs:subClassOf obo:BFO_0000040 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ] ) ] . obo:OBI_0100055 obo:IAO_0000111 "obsolete_cell line cell" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A material entity that represents generations of a primary culture." ; obo:IAO_0000117 "PERSON: Susanna Sansone" ; obo:IAO_0000119 "GROUP: OBI Biomaterial Branch" ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:Class ; rdfs:label "obsolete_cell line cell" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0100056 obo:IAO_0000111 "obsolete_immortal cell line culture" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cell line that is expected to be capable of indefinite propagation in an vitro culture." ; obo:IAO_0000117 "PERSON:Matthew Brush" ; obo:IAO_0000118 "immortal cell line sample", "permanent cell line" ; obo:IAO_0000119 "PERSON:Matthew Brush" ; obo:IAO_0000231 obo:IAO_0000228 ; obo:IAO_0100001 obo:CLO_0009828 ; a owl:Class ; rdfs:label "obsolete_immortal cell line culture" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0100058 obo:IAO_0000111 "xenograft"@en ; obo:IAO_0000112 "Human xenotransplantation (e.g. from pig to human) offers a potential treatment for end-stage organ failure, a significant health problem in parts of the industrialized world"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A material entity which results from the transplantation of living cells, tissues or organs from on organism of one species to an organism of another species."@en ; obo:IAO_0000117 "PERSON: Melanie Courtot"@en, "PERSON: Philippe Rocca-Serra" ; obo:IAO_0000118 "xenotransplant"@en ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Xenograft"@en ; a owl:Class ; rdfs:label "xenograft"@en ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000105 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:OBI_0100026 ] . obo:OBI_0100060 obo:IAO_0000111 "cultured cell population" ; obo:IAO_0000112 """A cultured cell population applied in an experiment: \"293 cells expressing TrkA were serum-starved for 18 hours and then neurotrophins were added for 10 min before cell harvest.\" (Lee, Ramee, et al. \"Regulation of cell survival by secreted proneurotrophins.\" Science 294.5548 (2001): 1945-1948). A cultured cell population maintained in vitro: \"Rat cortical neurons from 15 day embryos are grown in dissociated cell culture and maintained in vitro for 8–12 weeks\" (Dichter, Marc A. \"Rat cortical neurons in cell culture: culture methods, cell morphology, electrophysiology, and synapse formation.\" Brain Research 149.2 (1978): 279-293).""" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A processed material comprised of a collection of cultured cells that has been continuously maintained together in culture and shares a common propagation history." ; obo:IAO_0000116 "2013-6-5 MHB: This OBI class was formerly called 'cell culture', but label changed and definition updated following CLO alignment efforts in spring 2013, during which the intent of this class was clarified to refer to portions of a culture or line rather than a complete cell culture or line."@en ; obo:IAO_0000117 "PERSON:Matthew Brush" ; obo:IAO_0000118 "cell culture sample" ; obo:IAO_0000119 "PERSON:Matthew Brush" ; a owl:Class ; rdfs:comment "The extent of a 'cultured cell population' is restricted only in that all cell members must share a propagation history (ie be derived through a common lineage of passages from an initial culture). In being defined in this way, this class can be used to refer to the populations that researchers actually use in the practice of science - ie are the inputs to culturing, experimentation, and sharing. The cells in such populations will be a relatively uniform population as they have experienced similar selective pressures due to their continuous co-propagation. And this population will also have a single passage number, again owing to their common passaging history. Cultured cell populations represent only a collection of cells (ie do not include media, culture dishes, etc), and include populations of cultured unicellular organisms or cultured multicellular organism cells. They can exist under active culture, stored in a quiescent state for future use, or applied experimentally." ; rdfs:label "cultured cell population" ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600024 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:CL_0000010 ], [ a owl:Restriction ; owl:allValuesFrom obo:CL_0000010 ; owl:onProperty obo:OBI_0000643 ] . obo:OBI_0100061 obo:IAO_0000111 "primary cultured cell population" ; obo:IAO_0000112 "Spleen cells put directly into culture; Cold storage of biopsies from wild endangered native Chilean species in field conditions and subsequent isolation of primary culture cell lines. In Vitro Cell Dev Biol Anim. 2008 Jul 2. PMID: 18594934", "cells that have been isolated from some organismal source, expanded in culture, but not undergone a complete passaging (ie are still in culture, or have been lifted from culture and frozen in aliquots for future use)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cultured cell population comprised of cells expanded directly from living tissue prior to being passaged." ; obo:IAO_0000116 "2013-6-5 MHB: This OBI class was formerly called 'primary cell culture', but label changed and definition updated following CLO alignment work. Previous definition: 'a primary cell culture is a cell culture where the cells derive from a fresh tissue source.'" ; obo:IAO_0000117 "PERSON:Matthew Brush" ; obo:IAO_0000118 "primary cell culture", "primary cell culture sample" ; obo:IAO_0000119 "PERSON:Matthew Brush" ; a owl:Class ; rdfs:label "primary cultured cell population"@en ; rdfs:subClassOf obo:OBI_0100060, [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:CL_0000001 ], [ a owl:Restriction ; owl:allValuesFrom obo:CL_0000001 ; owl:onProperty obo:OBI_0000643 ], _:genid15048 . obo:OBI_0100062 obo:IAO_0000111 "obsolete_cell line" ; obo:IAO_0000112 "A split of HeLa cells in active culture, or stored in frozen aliquots. Populations of HEK 293 cells used in experiments such as those documented in Changes in ultrastructure and endogenous ionic channels activity during culture of HEK 293 cell line. Eur J Pharmacol. 2007 Jul 12;567(1-2):10-8. PMID: 17482592.", "He, Tong-Chuan, et al. Identification of c-MYC as a target of the APC pathway. Science 281.5382 (1998): 1509-1512. - To evaluate the transcriptional effects of APC, we studied a human colorectal cancer cell line (HT29-APC) containing a zinc-inducible APC gene and a control cell line (HT29–β-Gal) containing an analogous inducible lacZ gene. Note that common usage in the literature is often of the form a human colorectal cancer cell line, as seen above. But such references to studies in a line refer to the fact that discrete populations of cells that are input into culturing or experiments, not an entire lineage of cells. It is these discrete populations that we refer to as 'cell lines'." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A secondary cultured cell population that represents a genetically stable and homogenous population of cultured cells that shares a common propagation history (ie has been successively passaged together in culture)." ; obo:IAO_0000117 "PERSON:Matthew Brush" ; obo:IAO_0000118 "cell line sample" ; obo:IAO_0000119 "OBI-CLO Alignment Working Group (Spring 2013)" ; obo:IAO_0000231 obo:IAO_0000228 ; obo:IAO_0100001 obo:CLO_0000031 ; a owl:Class ; rdfs:label "obsolete_cell line" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0100063 obo:IAO_0000111 "cultured clonal cell population"@en ; obo:IAO_0000112 """cell cut Stem cell functions assessed in clonal culture. Soc Gen Physiol Ser. 1988;43:39-45. Review. PMID: 3077557"""@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cultured cell population comprised of cells which can all be traced back to a single ancestor cell, and which therefore can be treated as identical."@en ; obo:IAO_0000117 "PERSON: Susanna Sansone", "PERSON:Matthew Brush" ; obo:IAO_0000118 "clonal cell culture sample" ; obo:IAO_0000119 "GROUP: OBI Biomaterial Branch" ; a owl:Class ; rdfs:label "cultured clonal cell population"@en ; rdfs:subClassOf obo:OBI_0100060 . obo:OBI_0100064 obo:IAO_0000111 "screening library"@en ; obo:IAO_0000112 "PMID: 15615535.J Med Chem. 2004 Dec 30;47(27):6864-74.A screening library for peptide activated G-protein coupled receptors. 1. The test set. [cdna_library, phage display library]"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a screening library is a collection of materials engineered to identify qualities of a subset of its members during a screening process?"@en ; obo:IAO_0000116 """PRS: 22-02-2008: while working on definition of cDNA library and looking at current example of usage, a screening library should be a defined class -> any material library which has input_role in a screening protocol application change biomaterial to material in definition"""@en ; obo:IAO_0000117 "PERSON: Bjoern Peters"@en ; obo:IAO_0000119 "GROUP: IEDB" ; obo:IAO_0000232 "7/13/09: Need to clarify if this meets reagent role definition" ; a owl:Class ; rdfs:label "screening library"@en ; rdfs:subClassOf obo:OBI_0000047 . obo:OBI_0100065 obo:IAO_0000111 "synthetic peptide"@en ; obo:IAO_0000112 "the synthesized peptide SIINFEKL which also occurs in hen-egg lysozyme"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a synthetic peptide is an material entity which is artificially engineered and results from the synthesis of a chain of amino acids which may also be found in natural protein and be identical in sequence to a protein fragment"@en ; obo:IAO_0000116 "changed from synthetic polypeptide to peptide, to get rid of the restriction of having more than 10 amino acids (required by Chebi)."@en ; obo:IAO_0000117 "Bjoern Peters"@en ; obo:IAO_0000119 "IEDB"@en ; obo:IAO_0000232 "PRS:22-02-2008: a chebi entity which has output role in a synthesis protocol application"@en, """original term: protein fragment split into synthetic polypeptide and fragment derived from protein DS: Is this synthetic an oxymoron to the biomaterial?"""@en ; a owl:Class ; rdfs:label "synthetic peptide"@en ; rdfs:subClassOf obo:CHEBI_16670, obo:OBI_0000047 ; owl:equivalentClass _:genid15048 . obo:OBI_0100066 obo:IAO_0000111 "organ section"@en ; obo:IAO_0000112 """A liver slice used in a perfusion experiment. Thyroidectomy during laryngectomy for advanced laryngeal carcinoma--whole organ section study with long-term functional evaluation. Clin Otolaryngol Allied Sci. 1995 Apr;20(2):145-9. PMID: 7634521"""@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A processed material which derives from an organ and results from a process of dissection or histological sample preparation a portion(formerly an organ section is portion of an organ removed from the context of the organ)"@en ; obo:IAO_0000117 "PERSON: Helen Parkinson"@en, "PERSON: Philippe Rocca-Serra" ; obo:IAO_0000119 "GROUP: CEBS"@en, "GROUP: OBI Biomaterial Branch" ; a owl:Class ; rdfs:label "organ section"@en ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0000341 obo:OBI_0600005 ) ] ], [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0000465 ] . obo:OBI_0100067 obo:IAO_0000111 "bronchial alveolar lavage"@en ; obo:IAO_0000112 "solution containing lung derived T cells, eosinophils, and TNFa."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Group of biomaterials present in the bronchial aveolar space of an organism which are collected through lavage including the reagents used to for the lavage process, organisms, cells, and cellular secretions present in the bronchial aveolar space."@en ; obo:IAO_0000117 "PERSON: Bjoern Peters"@en ; obo:IAO_0000118 "BAL"@en ; obo:IAO_0000119 "GROUP: IEDB"@en ; a owl:Class ; rdfs:label "bronchial alveolar lavage"@en ; rdfs:subClassOf obo:OBI_0100051, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000112 ], [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0600044 ; owl:onProperty obo:OBI_0000312 ] . obo:OBI_0100069 obo:IAO_0000111 "obsolete_polymer" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." ; obo:IAO_0000117 "James Malone", "Philippe Rocca-Serra" ; obo:IAO_0000119 "TERM: CHEBI:33839" ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:Class ; rdfs:label "obsolete_polymer" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0100086 obo:IAO_0000111 "glucose in solution" ; obo:IAO_0000112 "Glucose present in blood" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A scattered aggregate of glucose molecules in a liquid" ; obo:IAO_0000117 "PERSON: Jie Zheng" ; obo:IAO_0000118 "glucose molecules" ; a owl:Class ; rdfs:label "glucose in solution" ; rdfs:subClassOf obo:BFO_0000040, [ a owl:Restriction ; owl:allValuesFrom obo:CHEBI_17234 ; owl:onProperty obo:OBI_0000643 ] . obo:OBI_0200000 obo:IAO_0000111 "data transformation"@en ; obo:IAO_0000112 "The application of a clustering protocol to microarray data or the application of a statistical testing method on a primary data set to determine a p-value." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A planned process that produces output data from input data."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Helen Parkinson"@en, "James Malone"@en, "Melanie Courtot"@en, "Philippe Rocca-Serra", "Richard Scheuermann"@en, "Ryan Brinkman"@en, "Tina Hernandez-Boussard"@en ; obo:IAO_0000118 "data analysis"@en, "data processing"@en ; obo:IAO_0000119 "Branch editors"@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "data transformation"@en ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000059 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:IAO_0000064 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:IAO_0000005 ] ) ] ] ], [ a owl:Restriction ; owl:allValuesFrom obo:IAO_0000027 ; owl:onProperty obo:OBI_0000293 ] ; owl:disjointWith obo:OBI_0600013 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200166 ] . obo:OBI_0200001 obo:IAO_0000111 "geometric mean calculation"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data transformation in which the mean is calculated by taking the nth root of the product of all of the observations in a data (n being the number of all observations)." ; obo:IAO_0000117 "Mathias Brochhausen"@en ; obo:IAO_0000119 "PERSON: Mathias Brochhausen"@en ; a owl:Class ; rdfs:comment "A geometric mean calculation is a descriptive statistics calculation in which the mean is calculated by taking the nth root of the product of all of the observations in a data (n being the number of all observations)."@en ; rdfs:label "geometric mean calculation"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200181, obo:OBI_0200184, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000674 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200177 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200078 ] . obo:OBI_0200002 obo:IAO_0000111 "logistic-log curve fitting"@en ; obo:IAO_0000112 "Typically used in an enzyme-linked immunosorbent assay (ELISA) to model the relationship between optical density (OD) and dilution. In this case a and d correspond to the theoretical OD of the assay at zero and infinite concentrations, respectively; c is the dilution associated with the point of symmetry of the sigmoid and is located at the midpoint of the assay found at the inflection point of the curve; b is a curvature parameter and is related to the slope of the curve."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A logistic-log curve fitting is a curve fitting where a curve of the form y=d+((a-d)/(1+(x/c)^b)) is obtained, where a, b, c, and d are determined so to optimize its fit to the input data points (x_1, y_1), (x_2, y_2), ..., (x_n, y_n)."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "James Malone"@en, "Melanie Courtot"@en, "Ryan Brinkman"@en ; obo:IAO_0000119 "ARTICLE: Plikaytis B.D. et al. (1991), J. Clin. Microbiol. 29(7): 1439-1448"@en ; a owl:Class ; rdfs:label "logistic-log curve fitting"@en ; rdfs:subClassOf obo:OBI_0200072, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200174 ] . obo:OBI_0200003 obo:IAO_0000111 "logit-log curve fitting"@en ; obo:IAO_0000112 "Typically used in an enzyme-linked immunosorbent assay (ELISA) to model the relationship between optical density (OD) and dilution. In this case OD_0 (also referred to OD_min) and OD_infty (also referred to OD_max) correspond to the theoretical OD of the assay at zero and infinite concentrations, respectively."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A logit-log curve fitting is a curve fitting where first the limits y_0 an y_infty of y when x->0 and x->infinity, respectively, are estimated from the input data points (x_1, y_1), (x_2,y_2), ..., (x_n, y_n). Then a curve with equation log((y-y_0)/(y_infty-y))=a+b log(x) is obtained, where a and b are determined to optimize its fit to the input data points."@en ; obo:IAO_0000116 "The above definition refers to the 'fully specified' logit-log model. The reduced form of this, when it is assumed that y_0=0, is named 'partially specified' logit-log model."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "James Malone"@en, "Melanie Courtot"@en, "Ryan Brinkman"@en ; obo:IAO_0000119 "ARTICLE: Plikaytis B.D. et al. (1991), J. Clin. Microbiol. 29(7): 1439-1448"@en ; a owl:Class ; rdfs:label "logit-log curve fitting"@en ; rdfs:subClassOf obo:OBI_0200072, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200174 ] . obo:OBI_0200004 obo:IAO_0000111 "log-log curve fitting"@en ; obo:IAO_0000112 "Typically used in an enzyme-linked immunosorbent assay (ELISA) to model the relationship between optical density (OD) and dilution."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A log-log curve fitting is a curve fitting where first a logarithmic transformation is applied both to the x and the y coordinates of the input data points (x_1, y_1), (x_2, y_2), ..., (x_n, y_n), and then coefficients a and b are determined to optimize the fit of log(y)=a+b*log(x) to these input data points."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "James Malone"@en, "Melanie Courtot"@en, "Ryan Brinkman"@en ; obo:IAO_0000119 "ARTICLE: Plikaytis B.D. et al. (1991), J. Clin. Microbiol. 29(7): 1439-1446"@en ; a owl:Class ; rdfs:label "log-log curve fitting"@en ; rdfs:subClassOf obo:OBI_0200072, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200174 ] . obo:OBI_0200005 obo:IAO_0000111 "feature extraction objective"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A feature extraction objective is a data transformation objective where the aim of the data transformation is to generate quantified values from a scanned image."@en ; obo:IAO_0000117 "Elisabetta Manduchi", "James Malone"@en ; obo:IAO_0000119 "TERM: http://mged.sourceforge.net/ontologies/MGEDOntology.owl#feature_extraction"@en ; a owl:Class ; rdfs:label "feature extraction objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0200006 obo:IAO_0000111 "biexponential transformation"@en ; obo:IAO_0000112 "This type of transformation is typically used in flow cytometry."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A biexponential transformation is a data transformation that, for each (one dimensional) real number input x, outputs an approximation (found, e.g. with the Newton's method) to a solution y of the equation B(y)-x=0, where B denotes a b transformation."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Joseph Spliden"@en, "Ryan Brinkman"@en ; obo:IAO_0000119 "WEB: http://flowcyt.sourceforge.net/gating/latest.pdf"@en ; a owl:Class ; rdfs:label "biexponential transformation"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200072, obo:OBI_0200169, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000451 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200174 ] . obo:OBI_0200007 obo:IAO_0000111 "box-cox transformation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A box-cox transformation is a data transformation according to the methods of Box and Cox as described in the article Box, G. E. P. and Cox, D.R. (1964) An analysis of transformations. Journal of Royal Statistical Society, Series B, vol. 26, pp. 211-246."@en ; obo:IAO_0000117 "Ryan Brinkman"@en ; obo:IAO_0000119 "ARTICLE: Box, G. E. P. and Cox, D.R. (1964), \"An analysis of transformations\", Journal of Royal Statistical Society, Series B, vol. 26, pp. 211-246."@en ; a owl:Class ; rdfs:label "box-cox transformation"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200008 obo:IAO_0000111 "hyperlog transformation"@en ; obo:IAO_0000112 "This type of transformation is typically used in flow cytometry"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A hyperlog transformation ia a data transformation that, for each (one dimensional) real number input x, outputs an approximation (found, e.g. with the Newton's method) to a solution y of the equation EH(y)-x=0, where EH denotes an eh transformation."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Joseph Spliden"@en, "Ryan Brinkman"@en ; obo:IAO_0000119 "ARTICLE: Bagwell C.B. (2006), \"Hyperlog - a flexible log-like transform for negative, zero, and positive valued data\", Cytometry A 64, 34-42.\""@en, "http://flowcyt.sourceforge.net/gating/latest.pdf"@en ; a owl:Class ; rdfs:label "hyperlog transformation"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200010 obo:IAO_0000111 "loess scale group transformation one-channel"@en ; obo:IAO_0000112 "Loess scale group normalization applied to data from two one-channel expression microarray assays."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A loess scale group transformation one-channel is a loess scale group transformation consisting in the application of a scale adjustment following a loess group transformation one-channel, to render the M group variances similar."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "OTHER: Editor's adjustment based on MGED Ontology term"@en ; a owl:Class ; rdfs:label "loess scale group transformation one-channel"@en ; rdfs:subClassOf obo:OBI_0200025 . obo:OBI_0200011 obo:IAO_0000111 "logical transformation"@en ; obo:IAO_0000112 "This type of transformation is typically used in flow cytometry."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A logical transformation is a data transformation that, for each (one dimensional) real number input x, outputs an approximation (found, e.g. with the Newton's method) to a solution y of the equation S(y)-x=0, where S denotes an s transformation."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Joseph Spliden"@en, "Ryan Brinkman"@en ; obo:IAO_0000119 "WEB: http://flowcyt.sourceforge.net/gating/latest.pdf"@en ; a owl:Class ; rdfs:label "logical transformation"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200012 obo:IAO_0000111 "loess scale group transformation two-channel"@en ; obo:IAO_0000112 "Loess scale group normalization applied to data from a two-channel expression microarray assay."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A loess scale group transformation two-channel is a loess scale group transformation consisting in the application of a scale adjustment following a loess group transformation two-channel, to render the M group variances similar."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "OTHER: Adjusted from MGED Ontology"@en ; a owl:Class ; rdfs:label "loess scale group transformation two-channel"@en ; rdfs:subClassOf obo:OBI_0200025 . obo:OBI_0200013 obo:IAO_0000111 "loess global transformation one-channel"@en ; obo:IAO_0000112 "Loess global normalization applied to data from two one-channel expression microarray assays, where the curve is obtained using all reporters. The goal is to remove intensity-dependent biases."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A loess global transformation one-channel is a loess global transformation in the special case where the input is the result of an MA transformation applied to intensities from two related one-channel assays."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "OTHER: Editor's generalization based on MGED Ontology term"@en ; a owl:Class ; rdfs:label "loess global transformation one-channel"@en ; rdfs:subClassOf obo:OBI_0200023 . obo:OBI_0200014 obo:IAO_0000111 "split-scale transformation"@en ; obo:IAO_0000112 "This type of transformation is typically used in flow cytometry"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A split-scale transformation is a data transformation which is an application of a function f described as follows to a (one dimensional) real number input. f(x)=a*x+b if x=for x>t; where log denotes a logarithmic transformation and a, b, c, d, r, t are real constants, with a, c, d, r, t positive, chosen so that f is continuous with a continuous derivative at the transition point t."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Joseph Spliden"@en, "Ryan Brinkman"@en ; obo:IAO_0000119 "WEB: http://flowcyt.sourceforge.net/gating/latest.pdf"@en ; a owl:Class ; rdfs:label "split-scale transformation"@en ; rdfs:subClassOf obo:OBI_0200000 . obo:OBI_0200015 obo:IAO_0000111 "loess global transformation two-channel"@en ; obo:IAO_0000112 "Loess global normalization applied to data from a two-channel expression microarray assay, where the curve is obtained using all reporters. The goal is to remove intensity-dependent biases."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A loess global transformation two-channel is a loess global transformation in the special case where the input the result of an MA transformation applied to intensities from the two channels of a two-channel assay."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "OTHER: Editor's generalization based on MGED Ontology term"@en ; a owl:Class ; rdfs:label "loess global transformation two-channel"@en ; rdfs:subClassOf obo:OBI_0200023 . obo:OBI_0200016 obo:IAO_0000111 "sine transformation"@en ; obo:IAO_0000112 "sine(0)=0, sine(pi/2)=1, sine(pi)=0, sine(3*pi/2)=-1, sine(pi/6)=1/2, sine(x+2*k*pi)=sine(x) where k is any integer, etc."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A sine transformation is a data transformation which consists in applying the sine function to a (one dimensional) real number input. The sine function is one of the basic trigonometric functions and a definition is provided, e.g., at http://mathworld.wolfram.com/Sine.html."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "WEB: http://mathworld.wolfram.com/Sine.html"@en ; a owl:Class ; rdfs:label "sine transformation"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200017 obo:IAO_0000111 "cosine transformation"@en ; obo:IAO_0000112 "cosine(0)=1, cosine(pi/2)=0, cosine(pi)=-1, cosine(3*pi/2)=0, cosine(pi/3)=1/2, cosine(x+2*k*pi)=cosine(x) where k is any integer, etc."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A cosine transformation is a data transformation which consists in applying the cosine function to a (one dimensional) real number input. The cosine function is one of the basic trigonometric functions and a definition is provided, e.g., at http://mathworld.wolfram.com/Cosine.html."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Philippe Rocca-Serra" ; obo:IAO_0000119 "WEB: http://mathworld.wolfram.com/Cosine.html"@en ; a owl:Class ; rdfs:label "cosine transformation"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200018 obo:IAO_0000111 "loess group transformation one-channel"@en ; obo:IAO_0000112 "A loess group transformation one-channel is a loess group transformation in the special case where the input is the result of an MA transformation applied to intensities from two related one-channel assays."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A loess group transformation one-channel is a loess group transformation in the special case where the input is the result of an MA transformation applied to intensities from two related one-channel assays."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "OTHER: Editor's generalization based on MGED Ontology term"@en ; a owl:Class ; rdfs:label "loess group transformation one-channel"@en ; rdfs:subClassOf obo:OBI_0200024 . obo:OBI_0200019 obo:IAO_0000111 "loess group transformation two-channel"@en ; obo:IAO_0000112 "A loess group transformation two-channel is a loess group transformation in the special case where the input is the result of an MA transformation applied to intensities from the two channels of a two-channel assay."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A loess group transformation two-channel is a loess group transformation in the special case where the input is the result of an MA transformation applied to intensities from the two channels of a two-channel assay."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "OTHER: Editor's generalization based on MGED Ontology term"@en ; a owl:Class ; rdfs:label "loess group transformation two-channel"@en ; rdfs:subClassOf obo:OBI_0200024 . obo:OBI_0200020 obo:IAO_0000111 "homogeneous polynomial transformation"@en ; obo:IAO_0000112 "a*x, with a non-zero, is a homogeneous polynomial of degree 1 in 1 variable, a*x^2, with a non-zero, is a homogeneous polynomial of degree 2 in 1 variable; a_1*x_1+...+a_n*x_n, with at least one of the a_i's non-zero, is a homogeneous polynomial of degree one in n variables; a*x_n^3+b*x_1*x_2*x_3, with at least one of a and b non-zero, is a homogeneous polynomial of degree 3 in n variables."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A homogeneous polynomial transformation is a polynomial transformation where all the term of the polynomial have the same degree."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "WEB: http://mathworld.wolfram.com/HomogeneousPolynomial.html"@en ; a owl:Class ; rdfs:label "homogeneous polynomial transformation"@en ; rdfs:subClassOf obo:OBI_0200093 . obo:OBI_0200021 obo:IAO_0000111 "linlog transformation"@en ; obo:IAO_0000112 "This can be used for microarray normalization, e.g. to normalize the data from a two-channel expression microarray assay, as described in PMID 16646782."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A linlog transformation is a data transformation, described in PMID 16646782, whose input is a matrix [y_ik] and whose output is a matrix obtained by applying formula (9) of this paper, where values below an appropriately determined threshold (dependent on the row i) are transformed via a polynomial of degree 1, and values above this threshold are transformed via a logarithm."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Philippe Rocca-Serra" ; obo:IAO_0000119 "PMID: 16646782"@en ; a owl:Class ; rdfs:label "linlog transformation"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200022 obo:IAO_0000111 "variance stabilizing transformation"@en ; obo:IAO_0000112 "This can be used for expression microarray assay normalization and it is referred to as \"variance stabilizing normalization\", according to the procedure described e.g. in PMID 12169536."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A variance stabilizing transformation is a data transformation, described in PMID 12169536, whose input is a matrix [y_ik] and whose output is a matrix obtained by applying formula (6) in this paper. One of the goals is to obtain an output matrix whose rows have equal variances. The method relies on various assumptions described in the paper."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "James Malone"@en, "Melanie Courtot"@en ; obo:IAO_0000118 "variance stabilising transformation"@en ; obo:IAO_0000119 "PMID: 12169536"@en ; a owl:Class ; rdfs:label "variance stabilizing transformation"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200023 obo:IAO_0000111 "loess global transformation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A loess global transformation is a loess transformation where only one loess fitting is performed, utilizing one subset of (or possibly all of) the data points in the input so that there is only one resulting loess curve y=f(x) which is used for the transformation."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "James Malone"@en, "Melanie Courtot"@en, "Philippe Rocca-Serra" ; obo:IAO_0000119 "OTHER: Editor's generalization based on MGED Ontology term"@en ; a owl:Class ; rdfs:label "loess global transformation"@en ; rdfs:subClassOf obo:OBI_0200071 . obo:OBI_0200024 obo:IAO_0000111 "loess group transformation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A loess group transformation is a loess transformation where the input is partitioned into groups and for each group a loess fitting is performed, utilizing a subset of (or possibly all of) the data points in that group. Thus, a collection of loess curves y=f_i(x) is generated, one per group. Each (x, y) in the input is transformed into (x, y-f_i(x)), where f_i(x) is the curve corresponding to the group to which that data point belongs."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "James Malone"@en, "Melanie Courtot"@en, "Philippe Rocca-Serra" ; obo:IAO_0000119 "OTHER: Editor's generalization based on MGED Ontology term"@en ; a owl:Class ; rdfs:label "loess group transformation"@en ; rdfs:subClassOf obo:OBI_0200071 . obo:OBI_0200025 obo:IAO_0000111 "loess scale group transformation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A loess scale group transformation is a data transformation consisting in the application of a scale adjustment following a loess group transformation, to render the group variances for the second variable (y) similar. Has objective scaling."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "James Malone"@en, "Melanie Courtot"@en ; obo:IAO_0000119 "OTHER: Editor's generalization based on MGED Ontology term"@en ; a owl:Class ; rdfs:label "loess scale group transformation"@en ; rdfs:subClassOf obo:OBI_0200185, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200183 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002087 ; owl:someValuesFrom obo:OBI_0200024 ] . obo:OBI_0200026 obo:IAO_0000111 "total intensity transformation single"@en ; obo:IAO_0000112 "This can be used as a simple normalization method for expression microarray assays. For example, each intensity from a one-channel microarray assay is multiplied by a constant so that the output mean intensity over the microarray equals a desired target T (the multiplicative constant in this case is the T/(mean intensity))."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A total intensity transformation single is a data transformation that takes as input an n-dimensional (real) vector and multiplies each component of this vector by a coefficient, where the coefficient is obtained by taking the sum of the input components or of a subset of these, multiplied by a constant of choice."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Helen Parkinson"@en, "James Malone"@en, "Melanie Courtot"@en, "Philippe Rocca-Serra" ; obo:IAO_0000119 "OTHER: Adjusted from MGED Ontology"@en ; obo:IAO_0000232 "Note that if the word \"sum\" is replaced by the word \"mean\" in the definition, the resulting definition is equivalent."@en ; a owl:Class ; rdfs:label "total intensity transformation single"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200027 obo:IAO_0000111 "total intensity transformation paired"@en ; obo:IAO_0000112 "This can be used as a simple normalization method for the two channels from a two-channel expression microarray assay or from two related one-channel expression microarray assays."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A total intensity transformation paired is a data transformation that takes as input two n-dimensional (real) vectors and multiplies each component of the first vector by a coefficient, where the coefficient is obtained by taking the ratio of the sum of the second input components or of a subset of these by the sum of the first input components or of a subset of these (the same subset is used for the two vectors)."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Philippe Rocca-Serra" ; obo:IAO_0000119 "OTHER: Adjusted from MGED Ontology"@en ; obo:IAO_0000232 "Note that if the word \"sum\" is replaced by the word \"mean\" in the definition, the resulting definition is equivalent."@en ; a owl:Class ; rdfs:label "total intensity transformation paired"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200028 obo:IAO_0000111 "quantile transformation"@en ; obo:IAO_0000112 "This can be used for expression microarray assay normalization and it is referred to as \"quantile normalization\", according to the procedure described e.g. in PMID 12538238."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A quantile transformation is a data transformation that takes as input a collection of data sets, where each can be thought as an n-dimensional (real) vector, and which transforms each data set so that the resulting output data sets have equal quantiles."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en ; a owl:Class ; rdfs:label "quantile transformation"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200169, obo:OBI_0200181, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000674 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200177 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200029 obo:IAO_0000111 "mean centering"@en ; obo:IAO_0000112 "This can be used as a normalization method in expression microarray assays. For example, given a two-channel microarray assay, the log ratios of the two channels (M values) can be mean-centered."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A mean centering is a data transformation that takes as input an n-dimensional (real) vector, performs a mean calculation on its components, and subtracts the resulting mean from each component of the input."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Philippe Rocca-Serra" ; obo:IAO_0000118 "mean centring"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en ; a owl:Class ; rdfs:label "mean centering"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200030 obo:IAO_0000111 "median centering"@en ; obo:IAO_0000112 "This can be used as a normalization method in expression microarray assays. For example, given a two-channel microarray assay, the log ratios of the two channels (M values) can be median-centered."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A median centering is a data transformation that takes as input an n-dimensional (real) vector, performs a median calculation on its components, and subtracts the resulting median from each component of the input."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Philippe Rocca-Serra" ; obo:IAO_0000118 "median centring"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en ; a owl:Class ; rdfs:label "median centering"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200031 obo:IAO_0000111 "differential expression analysis objective"@en ; obo:IAO_0000112 "Analyses implemented by the SAM (http://www-stat.stanford.edu/~tibs/SAM), PaGE (www.cbil.upenn.edu/PaGE) or GSEA (www.broad.mit.edu/gsea/) algorithms and software"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A differential expression analysis objective is a data transformation objective whose input consists of expression levels of entities (such as transcripts or proteins), or of sets of such expression levels, under two or more conditions and whose output reflects which of these are likely to have different expression across such conditions."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en ; a owl:Class ; rdfs:label "differential expression analysis objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0200032 obo:IAO_0000111 "K-fold cross validation method"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "K-fold cross-validation randomly partitions the original sample into K subsamples. Of the K subsamples, a single subsample is retained as the validation data for testing the model, and the remaining K - 1 subsamples are used as training data. The cross-validation process is then repeated K times (the folds), with each of the K subsamples used exactly once as the validation data. The K results from the folds then can be averaged (or otherwise combined) to produce a single estimation. The advantage of this method over repeated random sub-sampling is that all observations are used for both training and validation, and each observation is used for validation exactly once. 10-fold cross-validation is commonly used" ; obo:IAO_0000117 "Person:Helen Parkinson" ; obo:IAO_0000119 "Tina Boussard" ; a owl:Class ; rdfs:label "K-fold cross validation method"@en ; rdfs:subClassOf obo:OBI_0000792, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200188 ] . obo:OBI_0200033 obo:IAO_0000111 "leave one out cross validation method"@en ; obo:IAO_0000112 "The authors conducted leave-one-out cross validation to estimate the strength and accuracy of the differentially expressed filtered genes. http://bioinformatics.oxfordjournals.org/cgi/content/abstract/19/3/368" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is a data transformation : leave-one-out cross-validation (LOOCV) involves using a single observation from the original sample as the validation data, and the remaining observations as the training data. This is repeated such that each observation in the sample is used once as the validation data" ; obo:IAO_0000116 "2009-11-10. Tracker: https://sourceforge.net/tracker/?func=detail&aid=2893049&group_id=177891&atid=886178" ; obo:IAO_0000117 "Person:Helen Parkinson" ; a owl:Class ; rdfs:label "leave one out cross validation method"@en ; rdfs:subClassOf obo:OBI_0000792, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200188 ] . obo:OBI_0200034 obo:IAO_0000111 "jackknifing method" ; obo:IAO_0000112 "simple weighting procedure is suggested for combining information over alleles and loci, and sample variances may be estimated by a jackknife procedure" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Jacknifing is a re-sampling data transformation process used to estimate the precision of sampling statistics and is a resampling method" ; obo:IAO_0000117 "Helen Parkinson" ; obo:IAO_0000118 "jackknifing"@en ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Resampling_%28statistics%29" ; a owl:Class ; rdfs:label "jackknifing method"@en ; rdfs:subClassOf obo:OBI_0000792, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200188 ] . obo:OBI_0200035 obo:IAO_0000111 "boostrapping"@en ; obo:IAO_0000112 "Although widely accepted that high throughput biological data are typically highly noisy, the effects that this uncertainty has upon the conclusions we draw from these data are often overlooked. However, in order to assign any degree of confidence to our conclusions, we must quantify these effects. Bootstrap resampling is one method by which this may be achieved." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Bootstrapping is a statistical method for estimating the sampling distribution of a statistic by sampling with replacement from the original data, most often with the purpose of deriving robust estimates of standard errors and confidence intervals of a population parameter like a mean, median, proportion, odds ratio, correlation coefficient or regression coefficient"@en ; obo:IAO_0000117 "Helen Parkinson" ; obo:IAO_0000119 "Bootstrapping is a data transformation process which estimates the precision of sampling statistics by drawing randomly with replacement from a set of data points" ; a owl:Class ; rdfs:label "boostrapping"@en ; rdfs:subClassOf obo:OBI_0000792, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200188 ] . obo:OBI_0200036 obo:IAO_0000111 "Benjamini and Hochberg false discovery rate correction method"@en ; obo:IAO_0000112 "Statistical significance of the 8 most represented biological processes (GO level 4) among E7 6 month upregulated genes following analysis with DAVID software; Benjamini-Hochberg FDR (false discovery rate)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data transformation process in which the Benjamini and Hochberg method sequential p-value procedure is applied with the aim of correcting false discovery rate" ; obo:IAO_0000116 """2011-03-31: [PRS]. specified input and output of dt which were missing"""@en ; obo:IAO_0000117 "Helen Parkinson", "Philippe Rocca-Serra"@en ; obo:IAO_0000119 "Helen Parkinson" ; a owl:Class ; rdfs:label "Benjamini and Hochberg false discovery rate correction method"@en ; rdfs:subClassOf obo:OBI_0200163, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000175 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000662 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001442 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000791 ] . obo:OBI_0200037 obo:IAO_0000111 "pareto scaling"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A pareto scaling is a data transformation that divides all measurements of a variable by the square root of the standard deviation of that variable."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Philippe Rocca-Serra"@en ; obo:IAO_0000119 "PMID:16762068"@en ; a owl:Class ; rdfs:label "pareto scaling"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200040 obo:IAO_0000111 "modular decomposition"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Molecular decomposition is the partition of a network into distinct subgraphs for the purpose of identifying functional clusters. The network data is run through any of several existing algorithms designed to partition a network into distinct subgraphs for the purpose of isolating groups of functionally linked biological elements such as proteins."@en ; obo:IAO_0000117 "Tina Hernandez-Boussard"@en ; obo:IAO_0000119 "editor"@en ; a owl:Class ; rdfs:label "modular decomposition"@en ; rdfs:subClassOf obo:OBI_0200080 . obo:OBI_0200041 obo:IAO_0000111 "k-means clustering"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A k-means clustering is a data transformation which achieves a class discovery or partitioning objective, which takes as input a collection of objects (represented as points in multidimensional space) and which partitions them into a specified number k of clusters. The algorithm attempts to find the centers of natural clusters in the data. The most common form of the algorithm starts by partitioning the input points into k initial sets, either at random or using some heuristic data. It then calculates the mean point, or centroid, of each set. It constructs a new partition by associating each point with the closest centroid. Then the centroids are recalculated for the new clusters, and the algorithm repeated by alternate applications of these two steps until convergence, which is obtained when the points no longer switch clusters (or alternatively centroids are no longer changed)."@en ; obo:IAO_0000117 "Elisabetta Manduchi", "James Malone"@en, "Philippe Rocca-Serra" ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/K-means"@en ; a owl:Class ; rdfs:label "k-means clustering"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200171, obo:OBI_0200175, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000648 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200178 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200172 ] . obo:OBI_0200042 obo:IAO_0000111 "hierarchical clustering"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A hierarchical clustering is a data transformation which achieves a class discovery objective, which takes as input data item and builds a hierarchy of clusters. The traditional representation of this hierarchy is a tree (visualized by a dendrogram), with the individual input objects at one end (leaves) and a single cluster containing every object at the other (root)."@en ; obo:IAO_0000117 "James Malone"@en ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Data_clustering#Hierarchical_clustering"@en ; a owl:Class ; rdfs:label "hierarchical clustering"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200175, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000648 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200178 ] ) ] . obo:OBI_0200043 obo:IAO_0000111 "average linkage hierarchical clustering"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An average linkage hierarchical clustering is an agglomerative hierarchical clustering which generates successive clusters based on a distance measure, where the distance between two clusters is calculated as the average distance between objects from the first cluster and objects from the second cluster."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en ; a owl:Class ; rdfs:label "average linkage hierarchical clustering"@en ; rdfs:subClassOf obo:OBI_0200154 . obo:OBI_0200044 obo:IAO_0000111 "complete linkage hierarchical clustering"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "an agglomerative hierarchical clustering which generates successive clusters based on a distance measure, where the distance between two clusters is calculated as the maximum distance between objects from the first cluster and objects from the second cluster."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en ; a owl:Class ; rdfs:label "complete linkage hierarchical clustering"@en ; rdfs:subClassOf obo:OBI_0200154 . obo:OBI_0200045 obo:IAO_0000111 "single linkage hierarchical clustering"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A single linkage hierarchical clustering is an agglomerative hierarchical clustering which generates successive clusters based on a distance measure, where the distance between two clusters is calculated as the minimum distance between objects from the first cluster and objects from the second cluster."@en ; obo:IAO_0000117 "Elisabetta Manduchi" ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en ; a owl:Class ; rdfs:label "single linkage hierarchical clustering"@en ; rdfs:subClassOf obo:OBI_0200154 . obo:OBI_0200049 obo:IAO_0000111 "Benjamini and Yekutieli false discovery rate correction method"@en ; obo:IAO_0000112 "The expression set was compared univariately between the stroke patients and controls, gene list was generated using False Discovery Rate correction (Benjamini and Yekutieli)" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data transformation in which the Benjamini and Yekutieli method is applied with the aim of correcting false discovery rate" ; obo:IAO_0000116 """2011-03-31: [PRS]. specified input and output of dt which were missing"""@en ; obo:IAO_0000117 "Helen Parkinson", "Philippe Rocca-Serra"@en ; obo:IAO_0000119 "Helen Parkinson" ; a owl:Class ; rdfs:label "Benjamini and Yekutieli false discovery rate correction method"@en ; rdfs:subClassOf obo:OBI_0200163, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000175 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000662 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001442 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000791 ] . obo:OBI_0200050 obo:IAO_0000111 "dimensionality reduction"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A dimensionality reduction is data partitioning which transforms each input m-dimensional vector (x_1, x_2, ..., x_m) into an output n-dimensional vector (y_1, y_2, ..., y_n), where n is smaller than m."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "James Malone"@en, "Melanie Courtot"@en, "Philippe Rocca-Serra" ; obo:IAO_0000118 "data projection" ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en, "PERSON: James Malone"@en, "PERSON: Melanie Courtot"@en ; a owl:Class ; rdfs:label "dimensionality reduction"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200175, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000648 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200178 ] ) ] . obo:OBI_0200051 obo:IAO_0000111 "principal components analysis dimensionality reduction"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A principal components analysis dimensionality reduction is a dimensionality reduction achieved by applying principal components analysis and by keeping low-order principal components and excluding higher-order ones."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "James Malone"@en, "Melanie Courtot"@en, "Philippe Rocca-Serra" ; obo:IAO_0000118 "pca data reduction"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en, "PERSON: James Malone"@en, "PERSON: Melanie Courtot"@en ; a owl:Class ; rdfs:label "principal components analysis dimensionality reduction"@en ; rdfs:subClassOf obo:OBI_0200050 . obo:OBI_0200052 obo:IAO_0000111 "probabilistic algorithm"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A probabilistic algorithm is one which involves an element of probability or randomness in the transformation of the data."@en ; obo:IAO_0000117 "James Malone"@en ; obo:IAO_0000119 "PERSON: James Malone"@en ; a owl:Class ; rdfs:label "probabilistic algorithm"@en ; rdfs:subClassOf obo:OBI_0200000 . obo:OBI_0200053 obo:IAO_0000111 "expectation maximization"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "EM is a probabilistic algorithm used to estimate the maximum likelihood of parameters from existing data where the model involves unobserved latent variables. The input to this method is the data model for which the estimation is performed over and the output is an approximated probability function."@en ; obo:IAO_0000117 "James Malone"@en ; obo:IAO_0000119 "PERSON: James Malone"@en ; a owl:Class ; rdfs:label "expectation maximization"@en ; rdfs:subClassOf obo:OBI_0200052 . obo:OBI_0200054 obo:IAO_0000111 "global modularity calculation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A network graph quality calculation in which an input data set of subgraph modules and their in-degree and out-degree qualities is used to calculate the average modularity of subgraphs within the network."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "global modularity calculation"@en ; rdfs:subClassOf obo:OBI_0200147 . obo:OBI_0200055 obo:IAO_0000111 "dye swap merge"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A dye swap merge is a replicate analysis which takes as input data from paired two-channel microarray assays where the sample labeled with one dye in the first assay is labeled with the other dye in the second assay and vice versa. The output for each reporter is obtained by combining its (raw or possibly pre-processed) M values in the two assays, where the M value in an assay is defined as the difference of the log intensities in the two channels. This can be used as a normalization step, when appropriate assumptions are met."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "James Malone"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en, "PERSON: James Malone"@en ; a owl:Class ; rdfs:label "dye swap merge"@en ; rdfs:subClassOf obo:OBI_0200057 . obo:OBI_0200056 obo:IAO_0000111 "moving average"@en ; obo:IAO_0000112 "The moving average is often used to handle data from tiling arrays."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A moving average is a data transformation in which center calculations, usually mean calculations, are performed on values within a sliding window across the input data set."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Helen Parkinson"@en, "Philippe Rocca-Serra" ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en, "PERSON: Helen Parkinson"@en ; a owl:Class ; rdfs:label "moving average"@en ; rdfs:subClassOf obo:OBI_0200170, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000679 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000425 ] ) ] . obo:OBI_0200057 obo:IAO_0000111 "replicate analysis"@en ; obo:IAO_0000112 "Replicate analysis can be used in microarray analysis to identify and potentially exclude low quality data."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A replicate analysis is a data transformation in which data from replicates are combined, e.g. through descriptive statistics calculations, and the results might be utilized for a variety of purposes, like assessing reproducibility, identifying outliers, normalizing, etc."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Helen Parkinson"@en ; obo:IAO_0000119 "PERSON: Helen Parkinson"@en, "PERSON:Elisabetta Manduchi"@en ; a owl:Class ; rdfs:label "replicate analysis"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200058 obo:IAO_0000111 "b cell epitope prediction"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A B cell epitope prediction takes as input an antigen sequence, and through an analysis of this sequence, produces as output a prediction of the likelihood the biomaterial is a B Cell Epitope."@en ; obo:IAO_0000117 "Helen Parkinson"@en ; obo:IAO_0000119 "PERSON: Helen Parkinson"@en ; a owl:Class ; rdfs:label "b cell epitope prediction"@en ; rdfs:subClassOf obo:OBI_0200187, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200081 ] . obo:OBI_0200059 obo:IAO_0000111 "mhc binding prediction"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An MHC binding prediction takes an input of a biomaterial sequence and through an analysis of this sequence, produces as output a prediction of the likelihood that the biomaterial will bind to an MHC molecule."@en ; obo:IAO_0000117 "Helen Parkinson"@en ; obo:IAO_0000119 "PERSON: Helen Parkinson"@en ; a owl:Class ; rdfs:label "mhc binding prediction"@en ; rdfs:subClassOf obo:OBI_0200187, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200081 ] . obo:OBI_0200060 obo:IAO_0000111 "t cell epitope prediction"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A T cell epitope prediction takes as input an antigen sequence, and through an analysis of this sequence, produces as output a prediction of the likelihood the biomaterial is a T cell epitope."@en ; obo:IAO_0000117 "Helen Parkinson"@en ; obo:IAO_0000119 "PERSON: Helen Parkinson"@en ; a owl:Class ; rdfs:label "t cell epitope prediction"@en ; rdfs:subClassOf obo:OBI_0200187, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200081 ] . obo:OBI_0200061 obo:IAO_0000111 "data imputation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "Imputation is a means of filling in missing data values from a predictive distribution of the missing values. The predictive distribution can be created either based on a formal statistical model (i,e, a multivariate normal distribution) or an algorithm."@en ; obo:IAO_0000117 "Monnie McGee"@en ; obo:IAO_0000119 "ARTICLE: Little, RJA and Rubin, DB (2002). Statistical Analysis with Missing Data, Second Edition. John Wiley: Hoboken New Jersey, pp. 59-60."@en ; a owl:Class ; rdfs:label "data imputation"@en ; rdfs:subClassOf obo:OBI_0200000 . obo:OBI_0200062 obo:IAO_0000111 "continuum mass spectrum"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A continuum mass spectrum is a data transformation that contains the full profile of the detected signals for a given ion."@en ; obo:IAO_0000117 "PERSON: James Malone", "PERSON: Tina Hernandez-Boussard"@en ; obo:IAO_0000119 "PERSON: Tina Boussard"@en ; a owl:Class ; rdfs:label "continuum mass spectrum analysis"@en ; rdfs:subClassOf obo:OBI_0200085, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200197 ] . obo:OBI_0200063 obo:IAO_0000111 "characteristic path length calculation"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Quantifying subgraph navigability based on shortest-path length averaged over all pairs of subgraph vertices"@en ; obo:IAO_0000117 "PERSON: Tina Hernandez-Boussard"@en ; obo:IAO_0000119 "PERSON: Tina Hernandez-Boussard"@en ; a owl:Class ; rdfs:label "characteristic path length calculation"@en ; rdfs:subClassOf obo:OBI_0200085, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200197 ] . obo:OBI_0200064 obo:IAO_0000111 "centroid mass spectrum"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A centroid mass spectrum is a data transformation in which many points are used to delineate a mass spectral peak, is converted into mass-centroided data by a data compression algorithm. The centroided mass peak is located at the weighted center of mass of the profile peak. The normalized area of the peak provides the mass intensity data."@en ; obo:IAO_0000117 "Person:Tina Hernandez-Boussard"@en ; obo:IAO_0000118 "centroid mass spectrum calculation", "centroiding" ; obo:IAO_0000119 "centroid mass spectrum"@en ; a owl:Class ; rdfs:label "centroid mass spectrum analysis"@en ; rdfs:subClassOf obo:OBI_0200085, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200197 ] . obo:OBI_0200066 obo:IAO_0000111 "Holm-Bonferroni family-wise error rate correction method"@en ; obo:IAO_0000112 "t-tests were used with the type I error adjusted for multiple comparisons, Holm's correction (HOLM 1979), and false discovery rate, http://www.genetics.org/cgi/content/full/172/2/1179" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a data transformation that performs more than one hypothesis test simultaneously, a closed-test procedure, that controls the familywise error rate for all the k hypotheses at level α in the strong sense. Objective: multiple testing correction" ; obo:IAO_0000116 """2011-03-14: [PRS]. Class Label has been changed to address the conflict with the definition Also added restriction to specify the output to be a FWER adjusted p-value The 'editor preferred term' should be removed"""@en ; obo:IAO_0000117 "Person:Helen Parkinson", "Philippe Rocca-Serra"@en ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Holm%E2%80%93Bonferroni_method" ; a owl:Class ; rdfs:label "Holm-Bonferroni family-wise error rate correction method"@en ; rdfs:subClassOf obo:OBI_0200073, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000175 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001265 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000791 ] . obo:OBI_0200070 obo:IAO_0000111 "edge weighting"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Edge weighting is the substitution or transformation of edge length using numerical data. Data input include a symmetric adjacency matrix for a network and a second data set, for example a list of interactor pairs and a confidence score associated with the experimental detection of each pair's interaction. Each element in the adjacency matrix is transformed or replaced with the corresponding number in the second data set. Output data are a modified adjacency matrix reflecting the transformed state of the network."@en ; obo:IAO_0000117 "Tina Hernandez-Boussard"@en ; obo:IAO_0000119 "editor"@en ; obo:IAO_0000232 """was classified under algorithm class which is not acceptable super-class TO BE DEALT WITH STILL BY RICHARD. JAMES"""@en ; a owl:Class ; rdfs:label "edge weighting"@en ; rdfs:subClassOf obo:OBI_0200080 . obo:OBI_0200071 obo:IAO_0000111 "loess transformation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A loess transformation is a data transformation that takes as input a collection of real number pairs (x, y) and, after performing (one or more) loess fittings, utilizes the resulting curves to transform each (x, y) in the input into (x, y-f(x)) where f(x) is one of the fitted curves."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "James Malone"@en, "Melanie Courtot"@en, "Philippe Rocca-Serra" ; obo:IAO_0000119 "OTHER: Editor's generalization based on MGED Ontology term"@en ; a owl:Class ; rdfs:label "loess transformation"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200072 obo:IAO_0000111 "curve fitting data transformation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A curve fitting is a data transformation that has objective curve fitting and that consists of finding a curve which matches a series of data points and possibly other constraints."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "James Malone"@en, "Melanie Courtot"@en ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Curve_fitting"@en ; a owl:Class ; rdfs:label "curve fitting data transformation"@en ; rdfs:subClassOf obo:OBI_0200000 ; owl:equivalentClass [ a owl:Class ; owl:unionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000656 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200174 ] ) ] . obo:OBI_0200073 obo:IAO_0000111 "family wise error rate correction method"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A family wise error rate correction method is a multiple testing procedure that controls the probability of at least one false positive." ; obo:IAO_0000116 """2011-03-31: [PRS]. creating a defined class by specifying the necessary output of dt allows correct classification of FWER dt"""@en ; obo:IAO_0000117 "Monnie McGee", "Philippe Rocca-Serra"@en ; obo:IAO_0000118 "FWER correction"@en ; obo:IAO_0000119 "Dudoit, Sandrine and van der Laan, Mark J. (2008) Multiple Testing Procedures with Applications to Genomics. New York: Springer , p. 19" ; a owl:Class ; rdfs:label "family wise error rate correction method"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200089, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000791 ] ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001265 ] . obo:OBI_0200074 obo:IAO_0000111 "submatrix extraction"@en ; obo:IAO_0000112 "When presented with the data from an expression microarray experiment in the form of a matrix, whose rows correspond to genes and whose columns correspond to samples, if one filters some of the genes and/or some of the samples out, the resulting data set corresponds to a submatrix of the original set."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A submatrix extraction is a projection whose input is a matrix and whose output is a matrix obtained by selecting certain rows and columns from the input. (Note that, if one represents the input matrix as a vector obtained by concatenating its rows, then extracting a submatrix is equivalent to projecting this vector into that composed by the entries belonging to the rows and columns of interest from the input matrix.)"@en ; obo:IAO_0000116 "Note that this can be considered as a special case of projection if one represents the input matrix as a vector obtained by concatenating its rows. Then extracting a submatrix is equivalent to projecting this vector into the entries belonging to the rows and columns of interest from the input matrix."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "James Malone"@en, "Melanie Courtot"@en ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Submatrix"@en ; a owl:Class ; rdfs:label "submatrix extraction"@en ; rdfs:subClassOf obo:OBI_0200050 . obo:OBI_0200075 obo:IAO_0000111 "row submatrix extraction"@en ; obo:IAO_0000112 "When presented with the data from an expression microarray experiment in the form of a matrix, whose rows correspond to genes and whose columns correspond to samples, if one filters some of the genes out, the resulting data set corresponds to a row submatrix of the original set."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A row submatrix extraction is a submatrix extraction where all the columns of the input matrix are retained and selection only occurs on the rows."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "James Malone"@en, "Melanie Courtot"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en, "PERSON: James Malone"@en, "PERSON: Melanie Courtot"@en ; a owl:Class ; rdfs:label "row submatrix extraction"@en ; rdfs:subClassOf obo:OBI_0200074 . obo:OBI_0200076 obo:IAO_0000111 "column submatrix extraction"@en ; obo:IAO_0000112 "When presented with the data from an expression microarray experiment in the form of a matrix, whose rows correspond to genes and whose columns correspond to samples, if one filters some of the samples out, the resulting data set corresponds to a column submatrix of the original set."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A column submatrix extraction is a submatrix extraction where all the rows of the input matrix are retained and selection only occurs on the columns."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "James Malone"@en, "Melanie Courtot"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en, "PERSON: James Malone"@en, "PERSON: Melanie Courtot"@en ; a owl:Class ; rdfs:label "column submatrix extraction"@en ; rdfs:subClassOf obo:OBI_0200074 . obo:OBI_0200077 obo:IAO_0000111 "gating"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Gating is a property-based vector selection with the objective of partitioning a data vector set into vector subsets based on dimension values of individual vectors (events), in which vectors represent individual physical particles (often cells) of a sample and dimension values represent light intensity qualities as measured by flow cytometry."@en ; obo:IAO_0000117 "James Malone"@en, "Josef Spidlen"@en, "Melanie Courtot"@en, "Richard Scheuermann"@en, "Ryan Brinkman"@en ; obo:IAO_0000119 "PERSON: James Malone"@en, "PERSON: Josef Spidlen"@en, "PERSON: Richard Scheuermann"@en, "PERSON: Ryan Brinkman"@en, "PERSON:Melanie Courtot"@en ; a owl:Class ; rdfs:label "gating"@en ; rdfs:subClassOf obo:OBI_0200171, obo:OBI_0200182, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200157 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200172 ] . obo:OBI_0200078 obo:IAO_0000111 "descriptive statistical calculation objective"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A descriptive statistical calculation objective is a data transformation objective which concerns any calculation intended to describe a feature of a data set, for example, its center or its variability."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "James Malone"@en, "Melanie Courtot"@en, "Monnie McGee"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en, "PERSON: James Malone"@en, "PERSON: Melanie Courtot"@en, "PERSON: Monnie McGee"@en ; a owl:Class ; rdfs:label "descriptive statistical calculation objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0200079 obo:IAO_0000111 "arithmetic mean calculation"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An arithmetic mean calculation is a descriptive statistics calculation in which the mean is calculated by taking the sum of all of the observations in a data set divided by the total number of observations. It gives a measure of the 'center of gravity' for the data set. It is also known as the first moment."@en ; obo:IAO_0000117 "James Malone"@en, "Monnie McGee"@en, "Philippe Rocca-Serra" ; obo:IAO_0000119 "PERSON: James Malone"@en, "PERSON: Monnie McGee"@en ; obo:IAO_0000232 "From Monnie's file comments - need to add moment_calculation and center_calculation roles but they don't exist yet - (editor note added by James Jan 2008)"@en ; a owl:Class ; rdfs:label "arithmetic mean calculation"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200170, obo:OBI_0200181, obo:OBI_0200184, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000674 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200177 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000679 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000425 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200078 ] . obo:OBI_0200080 obo:IAO_0000111 "network analysis"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A data transformation that takes as input data that describes biological networks in terms of the node (a.k.a. vertex) and edge graph elements and their characteristics and generates as output properties of the constituent nodes and edges, the sub-graphs, and the entire network."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000118 "network topology analysis" ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "network analysis"@en ; rdfs:subClassOf obo:OBI_0200000 . obo:OBI_0200081 obo:IAO_0000111 "sequence analysis objective"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A sequence analysis objective is a data transformation objective which aims to analyse some ordered biological data for sequential patterns."@en ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "PERSON: James Malone" ; a owl:Class ; rdfs:label "sequence analysis objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0200082 obo:IAO_0000111 "longitudinal data analysis" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Longitudinal analysis is a data transformation used to perform repeated observations of the same items over long periods of time."@en ; obo:IAO_0000117 "PERSON: James Malone", "PERSON: Tina Boussard" ; obo:IAO_0000118 "correlation analysis", "longitudinal data analysis"@en ; a owl:Class ; rdfs:label "longitudinal data analysis"@en ; rdfs:subClassOf obo:OBI_0200000, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200196 ] . obo:OBI_0200083 obo:IAO_0000111 "survival analysis objective"@en ; obo:IAO_0000112 "Kaplan meier data transformation" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A data transformation objective which has the data transformation aims to model time to event data (where events are e.g. death and or disease recurrence); the purpose of survival analysis is to model the underlying distribution of event times and to assess the dependence of the event time on other explanatory variables" ; obo:IAO_0000117 "PERSON: James Malone", "PERSON: Tina Boussard" ; obo:IAO_0000118 "survival analysis" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Survival_analysis" ; a owl:Class ; rdfs:label "survival analysis objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0200085 obo:IAO_0000111 "mass spectrometry analysis"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A data transformation which has the objective of spectrum analysis." ; a owl:Class ; rdfs:label "mass spectrometry analysis"@en ; rdfs:subClassOf obo:OBI_0200000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200197 ] . obo:OBI_0200086 obo:IAO_0000111 "spread calculation data transformation"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A spread calculation is a data transformation that has objective spread calculation."@en ; obo:IAO_0000117 "James Malone"@en ; obo:IAO_0000119 "EDITOR" ; a owl:Class ; rdfs:label "spread calculation data transformation"@en ; rdfs:subClassOf obo:OBI_0200000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200180 ] . obo:OBI_0200088 obo:IAO_0000111 "Kaplan Meier"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a nonparametric (actuarial) data transformation technique for estimating time-related events. It is a univariate analysis that estimates the probability of the proportion of subjects in remission at a particular time, starting from the initiation of active date (time zero), and takes into account those lost to follow-up or not yet in remission at end of study (censored)" ; obo:IAO_0000117 "PERSON: James Malone", "PERSON: Tina Boussard" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Kaplan%E2%80%93Meier_estimator" ; a owl:Class ; rdfs:label "Kaplan Meier"@en ; rdfs:subClassOf obo:OBI_0200194, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200083 ] . obo:OBI_0200089 obo:IAO_0000111 "multiple testing correction method" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A multiple testing correction method is a hypothesis test performed simultaneously on M > 1 hypotheses. Multiple testing procedures produce a set of rejected hypotheses that is an estimate for the set of false null hypotheses while controlling for a suitably define Type I error rate" ; obo:IAO_0000117 "Monnie McGee" ; obo:IAO_0000118 "multiple testing procedure"@en ; obo:IAO_0000119 "PAPER: Dudoit, Sandrine and van der Laan, Mark J. (2008) Multiple Testing Procedures with Applications to Genomics. New York: Springer , p. 9-10." ; a owl:Class ; rdfs:label "multiple testing correction method"@en ; rdfs:subClassOf obo:OBI_0000668 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000791 ] . obo:OBI_0200091 obo:IAO_0000111 "inter-rater reliability objective" ; obo:IAO_0000112 """A study was conducted to determine the inter-rater reliability of common clinical examination procedures proposed to identify patients with lumbar segmental instability. Examples include joint-probability of agreement, Cohen's kappa and the related Fleiss' kappa, inter-rater correlation, concordance correlation coefficient and intra-class correlation.""" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a data transformation objective of determining the concordance or agreement between human judges." ; obo:IAO_0000117 "Person:Alan Ruttenberg", "Person:Helen Parkinson" ; obo:IAO_0000118 "inter-rater agreement" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Inter-rater_reliability" ; a owl:Class ; rdfs:label "inter-rater reliability objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0200092 obo:IAO_0000111 "Westfall and Young family wise error rate correction"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Is a data transformation process in which the Westfall and Young method is applied with the aim of controlling for multiple testing" ; obo:IAO_0000116 """2011-03-31: [PRS]. specified input and output of dt which were missing"""@en, "PRS: 2011-03-31: set specified input and specified output to the data transformation"@en ; obo:IAO_0000117 "Helen Parkinson" ; obo:IAO_0000118 "Westfall and Young FWER correction"@en ; a owl:Class ; rdfs:label "Westfall and Young family wise error rate correction"@en ; rdfs:subClassOf obo:OBI_0200073, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000175 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001265 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000791 ] . obo:OBI_0200093 obo:IAO_0000111 "polynomial transformation"@en ; obo:IAO_0000112 """a*x+b, with a non-zero, is a polynomial of degree one in one variable; a*x^2+b*x+c, with a nonzero, is a polynomial of degree 2 in 1 variable; a*x*y+b*y+c, with a non-zero, is a polynomial of degree 2 in 2 variables (x and y); a_1*x_1+...+a_n*x_n+b, with at least one of the a_i's non-zero, is a polynomial of degree one in n variables"""@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A polynomial transformation is a data transformation that is obtained through a polynomial, where a polynomial is a mathematical expression involving a sum of powers in one or more variables multiplied by coefficients (e.g. see http://mathworld.wolfram.com/Polynomial.html). The number of variables and the degree are properties of a polynomial. The degree of a polynomial is the highest power of its terms, where the terms of a polynomial are the individual summands with the coefficients omitted."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "WEB: http://mathworld.wolfram.com/Polynomial.html"@en ; a owl:Class ; rdfs:label "polynomial transformation"@en ; rdfs:subClassOf obo:OBI_0200000 . obo:OBI_0200094 obo:IAO_0000111 "logarithmic transformation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A logarithmic transformation is a data transformation consisting in the application of the logarithm function with a given base a (where a>0 and a is not equal to 1) to a (one dimensional) positive real number input. The logarithm function with base a can be defined as the inverse of the exponential function with the same base. See e.g. http://en.wikipedia.org/wiki/Logarithm."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Logarithm"@en ; a owl:Class ; rdfs:label "logarithmic transformation"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200095 obo:IAO_0000111 "exponential transformation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An exponential transformation is a data transformation consisting in the application of the exponential function with a given base a (where a>0 and a is typically not equal to 1) to a (one dimensional) real number input. For alternative definitions and properties of this function see, e.g., http://en.wikipedia.org/wiki/Exponential_function and http://en.wikipedia.org/wiki/Characterizations_of_the_exponential_function."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Characterizations_of_the_exponential_function"@en, "WEB: http://en.wikipedia.org/wiki/Exponential_function"@en ; a owl:Class ; rdfs:label "exponential transformation"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200097 obo:IAO_0000111 "non-negative matrix factorization" ; obo:IAO_0000112 "Non-negative matrix factorization is used in text mining where document-term matrix is constructed with the weights of various terms (typically weighted word frequency information) from a set of documents. This matrix is factored into a term-feature and a feature-document matrix." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Non negative matrix factorization is a data transformation in which factorises a matrix and which forces that all elements must be equal to or greater than zero." ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Non-negative_matrix_factorization" ; a owl:Class ; rdfs:label "non-negative matrix factorization"@en ; rdfs:subClassOf obo:OBI_0200000 . obo:OBI_0200098 obo:IAO_0000111 "soft independent modeling of class analogy analysis" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Soft independent modeling by class analogy (SIMCA) is a descriptive statistics method for supervised classification of data. The method requires a training data set consisting of samples (or objects) with a set of attributes and their class membership. The term soft refers to the fact the classifier can identify samples as belonging to multiple classes and not necessarily producing a classification of samples into non-overlapping classes."@en ; obo:IAO_0000117 "Tina Hernandez-Boussard"@en ; obo:IAO_0000118 "SIMCA"@en ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Soft_independent_modelling_of_class_analogies"@en ; a owl:Class ; rdfs:label "soft independent modeling of class analogy analysis"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200099 obo:IAO_0000111 "discriminant function analysis"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Discriminant function analysis is a form of discriminant analysis used to determine which variables discriminate between two or more naturally occurring groups. Analysis is used to determine which variable(s) are the best predictors of a particular outcome."@en ; obo:IAO_0000117 "Tina Hernandez-Boussard"@en ; obo:IAO_0000119 "WEB: http://www.statsoft.com/textbook/stdiscan.html"@en ; a owl:Class ; rdfs:label "discriminant function analysis"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0000663, obo:OBI_0200106, obo:OBI_0200175, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000023 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200179 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000648 ] . obo:OBI_0200100 obo:IAO_0000111 "canonical variate analysis"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "canonical variate analysis is a form of discriminant analysis that takes several continuous predictor variables and uses the entire set to predict several criterion variables, each of which is also continuous. CVA simultaneously calculates a linear composite of all x variables and a linear composite of all y variables. Unlike other multivariate techniques, these weighted composites are derived in pairs. Each linear combination is called a canonical variate and takes the general linear form."@en ; obo:IAO_0000117 "Tina Hernandez-Boussard"@en ; obo:IAO_0000118 "CVA"@en ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Canonical_analysis"@en ; a owl:Class ; rdfs:label "canonical variate analysis"@en ; rdfs:subClassOf obo:OBI_0200106, obo:OBI_0200171, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200172 ] . obo:OBI_0200101 obo:IAO_0000111 "linear discriminant functional analysis"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Linear discriminant functional analysis (LDFA) is a multivariate technique used in special applications where there are several intact groups (random assignment may be impossible) and they have been measured on several independent measures. Thus, you will want to describe how these groups differ on the basis of these measures. In this case, classification and prediction is the main objective."@en ; obo:IAO_0000117 "Tina Hernandez-Boussard"@en ; obo:IAO_0000119 "PERSON: Tina Hernandez-Boussard"@en ; a owl:Class ; rdfs:label "linear discriminant functional analysis"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0000663, obo:OBI_0200106, obo:OBI_0200175, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000023 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200179 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000648 ] . obo:OBI_0200102 obo:IAO_0000111 "regression analysis method"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Regression analysis is a descriptive statistics technique that examines the relation of a dependent variable (response variable) to specified independent variables (explanatory variables). Regression analysis can be used as a descriptive method of data analysis (such as curve fitting) without relying on any assumptions about underlying processes generating the data."@en ; obo:IAO_0000117 "Tina Hernandez-Boussard"@en ; obo:IAO_0000119 "BOOK: Richard A. Berk, Regression Analysis: A Constructive Critique, Sage Publications (2004) 978-0761929048"@en ; a owl:Class ; rdfs:label "regression analysis method"@en ; rdfs:subClassOf obo:OBI_0200000 . obo:OBI_0200103 obo:IAO_0000111 "multiple linear regression analysis"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 """multiple linear regression is a regression method that models the relationship between a dependent variable Y, independent variables Xi, i = 1, ..., p, and a random term epsilon. The model can be written as Y = \\beta_0 + \\beta_1 X_1 + \\beta_2 X_2 + \\cdots +\\beta_p X_p + \\varepsilon where \\beta_0 = 0 is the intercept (\"constant\" term), the \\beta_i s are the respective parameters of independent variables, and p is the number of parameters to be estimated in the linear regression."""@en ; obo:IAO_0000117 "Tina Hernandez-Boussard"@en ; obo:IAO_0000119 "WEB:http://en.wikipedia.org/wiki/Linear_regression"@en ; a owl:Class ; rdfs:label "multiple linear regression analysis"@en ; rdfs:subClassOf obo:OBI_0200102 . obo:OBI_0200104 obo:IAO_0000111 "principal component regression"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "The Principal Component Regression method is a regression analysis method that combines the Principal Component Analysis (PCA)spectral decomposition with an Inverse Least Squares (ILS) regression method to create a quantitative model for complex samples. Unlike quantitation methods based directly on Beer's Law which attempt to calculate the absorbtivity coefficients for the constituents of interest from a direct regression of the constituent concentrations onto the spectroscopic responses, the PCR method regresses the concentrations on the PCA scores."@en ; obo:IAO_0000117 "Tina Hernandez-Boussard"@en ; obo:IAO_0000119 "WEB: : http://www.thermo.com/com/cda/resources/resources_detail/1,2166,13414,00.html"@en ; a owl:Class ; rdfs:label "principal component regression"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200102, obo:OBI_0200175, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000648 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200178 ] ) ] . obo:OBI_0200105 obo:IAO_0000111 "partial least square regression analysis"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 """Partial least squares regression is an extension of the multiple linear regression model (see, e.g., Multiple Regression or General Stepwise Regression). In its simplest form, a linear model specifies the (linear) relationship between a dependent (response) variable Y, and a set of predictor variables, the X's, so that Y = b0 + b1X1 + b2X2 + ... + bpXp In this equation b0 is the regression coefficient for the intercept and the bi values are the regression coefficients (for variables 1 through p) computed from the data."""@en ; obo:IAO_0000117 "Tina Hernandez-Boussard"@en ; obo:IAO_0000118 "PLS-RA"@en ; obo:IAO_0000119 "ARTICLE: de Jong, S. (1993). SIMPLS: An alternative approach to partial least squares regression. Chemometrics and Intelligent Laboratory Systems, 18: 251-263."@en ; a owl:Class ; rdfs:label "partial least square regression analysis"@en ; rdfs:subClassOf obo:OBI_0200102 . obo:OBI_0200106 obo:IAO_0000111 "discriminant analysis"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Discriminant function analysis is used to determine which variables discriminate between two or more naturally occurring groups. Analysis is used to determine which variable(s) are the best predictors of a particular outcome."@en ; obo:IAO_0000117 "Tina Hernandez-Boussard"@en ; obo:IAO_0000119 "WEB: http://www.statsoft.com/textbook/stdiscan.html"@en ; a owl:Class ; rdfs:label "discriminant analysis"@en ; rdfs:subClassOf obo:OBI_0200000 . obo:OBI_0200107 obo:IAO_0000111 "partial least square discriminant analysis"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "PLS Discriminant Analysis (PLS-DA) is a discriminant analysis performed in order to sharpen the separation between groups of observations, by hopefully rotating PCA (Principal Components Analysis) components such that a maximum separation among classes is obtained, and to understand which variables carry the class separating information." ; obo:IAO_0000117 "James Malone"@en ; obo:IAO_0000118 "PLS-DA"@en ; obo:IAO_0000119 "WEB: http://www.camo.com/rt/Resources/pls-da.html" ; a owl:Class ; rdfs:label "partial least square discriminant analysis"@en ; rdfs:subClassOf obo:OBI_0200106 . obo:OBI_0200108 obo:IAO_0000111 "eh transformation"@en ; obo:IAO_0000112 "This type of transformation is typically used in flow cytometry."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An eh transformation is a data transformation obtained by applying the function EH described in what follows to a (one dimensional) real number input. EH(x)=exp(x*d/r)+b*(d/r)*x-1, if x>=0, and EH(x)=-exp(-x*d/r)+b*(d/r)*x+1, otherwise. Here exp denotes an exponential transformation and b, d, r are positive real constants with the objective of normalization."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Joseph Spliden"@en, "Ryan Brinkman"@en ; obo:IAO_0000119 "WEB: http://flowcyt.sourceforge.net/gating/latest.pdf"@en ; a owl:Class ; rdfs:label "eh transformation"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200109 obo:IAO_0000111 "b transformation"@en ; obo:IAO_0000112 "This type of transformation is typically used in flow cytometry."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A b transformation is a data transformation obtained by applying the function B described in what follows to a (one dimensional) real number input. B(x)= a*exp(b*x)-c*exp(-d*x)+f, where exp denotes an exponential transformation and a, b, c, d, f are real constants with a, b, c, d positive with the objective of normalization."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Joseph Spliden"@en, "Ryan Brinkman"@en ; obo:IAO_0000119 "WEB: http://flowcyt.sourceforge.net/gating/latest.pdf"@en ; a owl:Class ; rdfs:label "b transformation"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200169, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000451 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] ) ] . obo:OBI_0200110 obo:IAO_0000111 "s transformation"@en ; obo:IAO_0000112 "This type of transformation is typically used in flow cytometry."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An s transformation is a data transformation obtained by applying the function S described in what follows to a (one dimensional) real number input. S(x)=T*exp(w-m)*(exp(x-w)-(p^2)*exp((w-x)/p)+p^2-1) if x>=w, S(x)=-S(w-x) otherwise; where exp denotes an exponential_transformations, 'p^' denotes the exponential transformation with base p; T, w, m, p are real constants with T, m, and p positive and w non-negative, and where w and p are related by w=2p*ln(p)(p+1) with the objective of normalization."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Joseph Spliden"@en, "Ryan Brinkman"@en ; obo:IAO_0000119 "WEB: http://flowcyt.sourceforge.net/gating/latest.pdf"@en ; a owl:Class ; rdfs:label "s transformation"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200111 obo:IAO_0000111 "data visualization" ; obo:IAO_0000112 "Generation of a heatmap from a microarray dataset" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A planned process with the objective to graphically represent some data by inputing the data and outputting images, diagrams or animations."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "James Malone"@en, "Melanie Courtot"@en, "Tina Boussard"@en ; obo:IAO_0000118 "data encoding as image", "visualization"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en, "PERSON: James Malone"@en, "PERSON: Melanie Courtot"@en, "PERSON: Tina Boussard"@en ; obo:IAO_0000232 """Possible future hierarchy might include this: information_encoding >data_encoding >>image_encoding""" ; a owl:Class ; rdfs:label "data visualization"@en ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:IAO_0000027 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:IAO_0000038 obo:IAO_0000101 ) ] ], [ a owl:Restriction ; owl:allValuesFrom obo:IAO_0000027 ; owl:onProperty obo:OBI_0000293 ], [ a owl:Restriction ; owl:allValuesFrom [ a owl:Class ; owl:unionOf (obo:IAO_0000038 obo:IAO_0000101 ) ] ; owl:onProperty obo:OBI_0000299 ] . obo:OBI_0200113 obo:IAO_0000111 "similarity calculation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A similarity calculation is a data transformation that attaches to each pair of objects in the input a number that is meant to reflect how 'close' or 'similar' those objects are."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en ; a owl:Class ; rdfs:label "similarity calculation"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0000663, obo:OBI_0200175, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000023 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000648 ] . obo:OBI_0200114 obo:IAO_0000111 "euclidean distance calculation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An euclidean distance calculation is a similarity calculation that attaches to each pair of real number vectors of the same dimension n the square root of the sum of the square differences between corresponding components. The smaller this number, the more similar the two vectors are considered."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en ; a owl:Class ; rdfs:label "euclidean distance calculation"@en ; rdfs:subClassOf obo:OBI_0200113 . obo:OBI_0200115 obo:IAO_0000111 "pearson correlation coefficient calculation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A pearson correlation coefficient calculation is a similarity calculation which attaches to each pair of random variables X and Y the ratio of their covariance by the product of their standard deviations. Given a series of n measurements of X and Y written as x_i and y_i where i = 1, 2, ..., n, then their Pearson correlation coefficient refers to the \"sample correlation coefficient\" and is written as the sum over i of the ratios (x_i-xbar)*(y_i-ybar)/((n-1)*s_x*s_y) where xbar and ybar are the sample means of X and Y , s_x and s_y are the sample standard deviations of X and Y. The closer the pearson correlation coefficient is to 1, the more similar the inputs are considered."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en, "WEB: http://en.wikipedia.org/wiki/Correlation"@en ; a owl:Class ; rdfs:label "pearson correlation coefficient calculation"@en ; rdfs:subClassOf obo:OBI_0200113 . obo:OBI_0200116 obo:IAO_0000111 "loess fitting"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A loess fitting is a curve fitting obtained by localized regression. The latter refers to fitting a polynomial (straight line, quadratic, cubic, etc) to data values within a window covering a fraction of the total number of observations. As the window slides along the axis, a new polynomial is fit to the observations falling within the window. This continues until all points are fit with a local polynomial. The results are then smoothed together to form a curve. The smoothness of loess fits is controlled by a smoothing parameter (often denoted as alpha, usually between 1/4 and 1) and the degree of the polynomial that is fitted by the method (usually denoted by lambda)."@en ; obo:IAO_0000117 "Monnie McGee"@en, "Philippe Rocca-Serra" ; obo:IAO_0000119 "ARTICLE: Mathematical details of loess fits are given in Cleveland, William (1993) Visualizing Data. Hobart Press, Summit, New Jersey, pp. 94-101."@en ; a owl:Class ; rdfs:label "loess fitting"@en ; rdfs:subClassOf obo:OBI_0200072, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200174 ] . obo:OBI_0200117 obo:IAO_0000111 "mode calculation"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A mode calculation is a descriptive statistics calculation in which the mode is calculated which is the most common value in a data set. It is most often used as a measure of center for discrete data."@en ; obo:IAO_0000117 "James Malone"@en, "Monnie McGee"@en ; obo:IAO_0000119 "PERSON: James Malone"@en, "PERSON: Monnie McGee"@en ; obo:IAO_0000232 "From Monnie's file comments - need to add center_calculation role but it doesn't exist yet - (editor note added by James Jan 2008)"@en ; a owl:Class ; rdfs:label "mode calculation"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200181, obo:OBI_0200184, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000674 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200177 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200078 ] . obo:OBI_0200118 obo:IAO_0000111 "quantile calculation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A quantile calculation is a descriptive statistics calculation in which the kth quantile is the data value for which an approximate k fraction of the data is less than or equal to that value. See http://www.stat.wvu.edu/SRS/Modules/Quantiles/quantiles.html for details."@en ; obo:IAO_0000117 "Monnie McGee"@en ; obo:IAO_0000119 "WEB: http://www.stat.wvu.edu/SRS/Modules/Quantiles/quantiles.html"@en ; a owl:Class ; rdfs:label "quantile calculation"@en ; rdfs:subClassOf obo:OBI_0200184, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200078 ] . obo:OBI_0200119 obo:IAO_0000111 "median calculation"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A median calculation is a descriptive statistics calculation in which the midpoint of the data set (the 0.5 quantile) is calculated. First, the observations are sorted in increasing order. For an odd number of observations, the median is the middle value of the sorted data. For an even number of observations, the median is the average of the two middle values."@en ; obo:IAO_0000117 "James Malone"@en, "Monnie McGee"@en ; obo:IAO_0000119 "PERSON: James Malone"@en, "PERSON: Monnie McGee"@en ; obo:IAO_0000232 "From Monnie's file comments - need to add center_calculation role but it doesn't exist yet - (editor note added by James Jan 2008)"@en ; a owl:Class ; rdfs:label "median calculation"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200181, obo:OBI_0200184, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000674 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200177 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200078 ] . obo:OBI_0200120 obo:IAO_0000111 "variance calculation"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A variance calculation is a descriptive statistics calculation in which the variance is defined as the average squared distance of each observation in the data set to the mean of the data set. It is also known as the second central moment."@en ; obo:IAO_0000117 "Monnie McGee"@en ; obo:IAO_0000119 "PERSON: Monnie McGee"@en ; obo:IAO_0000232 "From Monnie's file comments - need to add spread_calculation and moment_calculation roles but they don't exist yet - (editor note added by James Jan 2008)"@en ; a owl:Class ; rdfs:label "variance calculation"@en ; rdfs:subClassOf obo:OBI_0200086, obo:OBI_0200184, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200078 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200180 ] . obo:OBI_0200121 obo:IAO_0000111 "standard deviation calculation"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A standard deviation calculation is a descriptive statistics calculation defined as the square root of the variance. Also thought of as the average distance of each value to the mean."@en ; obo:IAO_0000117 "Monnie McGee"@en ; obo:IAO_0000119 "PERSON: Monnie McGee"@en ; obo:IAO_0000232 "From Monnie's file comments - need to add spread calculation role but they doesn't exist yet - (editor note added by James Jan 2008)"@en ; a owl:Class ; rdfs:label "standard deviation calculation"@en ; rdfs:subClassOf obo:OBI_0200086, obo:OBI_0200184, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200078 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200180 ] . obo:OBI_0200122 obo:IAO_0000111 "interquartile-range calculation"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The interquartile range is a descriptive statistics calculation defined as the difference between the 0.75 quantile and the 0.25 quantile for a set of data."@en ; obo:IAO_0000117 "Monnie McGee"@en ; obo:IAO_0000119 "PERSON: Monnie McGee"@en ; obo:IAO_0000232 "From Monnie's file comments - need to add spread calculation role but they doesn't exist yet - (editor note added by James Jan 2008)"@en ; a owl:Class ; rdfs:label "interquartile-range calculation"@en ; rdfs:subClassOf obo:OBI_0200086, obo:OBI_0200184, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200078 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200180 ] . obo:OBI_0200123 obo:IAO_0000111 "skewness calculation"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A skewness calculation is a descriptive statistics calculation defined as a parameter that describes how much a distribution (or a data set) varies from a bell-shaped curve. See http://www.riskglossary.com/link/skewness.htm for details. It is also known as the third central moment"@en ; obo:IAO_0000117 "Monnie McGee"@en ; obo:IAO_0000119 "WEB: http://www.riskglossary.com/link/skewness.htm"@en ; obo:IAO_0000232 "From Monnie's file comments - need to add moment calculation role but they doesn't exist yet - (editor note added by James Jan 2008)"@en ; a owl:Class ; rdfs:label "skewness calculation"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200181, obo:OBI_0200184, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000674 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200177 ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200078 ] . obo:OBI_0200124 obo:IAO_0000111 "kurtosis calculation"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A kurtosis calculation is a descriptive statistics calculation defined as a parameter that measures how large or small the tails of a distribution are relative to the mean. For details, see http://davidmlane.com/hyperstat/A53638.html"@en ; obo:IAO_0000117 "Monnie McGee"@en ; obo:IAO_0000119 "WEB: http://davidmlane.com/hyperstat/A53638.html"@en ; obo:IAO_0000232 "From Monnie's file comments - need to add moment calculation role but they doesn't exist yet - (editor note added by James Jan 2008)"@en ; a owl:Class ; rdfs:label "kurtosis calculation"@en ; rdfs:subClassOf obo:OBI_0200086, obo:OBI_0200184, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200078 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200180 ] . obo:OBI_0200125 obo:IAO_0000111 "data combination"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A data transformation in which individual input data elements and values are merged together into a output set of data elements and values."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000118 "data pooling" ; obo:IAO_0000119 "editor"@en ; a owl:Class ; rdfs:label "data combination"@en ; rdfs:subClassOf obo:OBI_0200000, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200189 ] . obo:OBI_0200126 obo:IAO_0000111 "network graph construction"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A network analysis in which an input data set describing objects and relationships between objects is transformed into an output representation of these objects as nodes and the relationships as edges of a network graph."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "network graph construction"@en ; rdfs:subClassOf obo:OBI_0200080 . obo:OBI_0200127 obo:IAO_0000111 "weighted network graph construction"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A network graph construction in which an input data set describing objects and quantitative relationships between objects is transformed into and output representation of these objects as nodes and the quantitative relationships as weighted edges of a network graph."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "weighted network graph construction"@en ; rdfs:subClassOf obo:OBI_0200126 . obo:OBI_0200128 obo:IAO_0000111 "directed network graph construction"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A network graph construction in which an input data set describing objects and directional relationships between objects is transformed into and output representation of these objects as nodes and the directional relationships as directed edges of a network graph."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "directed network graph construction"@en ; rdfs:subClassOf obo:OBI_0200126 . obo:OBI_0200129 obo:IAO_0000111 "node quality calculation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A network analysis in which an input data set describing node objects and edge relationships between node objects is used to determine the output quality of one of the node objects in the network."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "node quality calculation"@en ; rdfs:subClassOf obo:OBI_0200080 . obo:OBI_0200130 obo:IAO_0000111 "node degree calculation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A node quality calculation in which an input data set describing object nodes and relationship edges between object nodes is used to enumerate the number of unique relationships of an individual object node."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "node degree calculation"@en ; rdfs:subClassOf obo:OBI_0200129 . obo:OBI_0200131 obo:IAO_0000111 "quantitative node degree calculation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A node quality calculation in which an input data set describing object nodes and quantitative relationship edges between object nodes is used to sum all of the quantitative relationships of an individual object node."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "quantitative node degree calculation"@en ; rdfs:subClassOf obo:OBI_0200129 . obo:OBI_0200132 obo:IAO_0000111 "node in-degree calculation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A node quality calculation in which an input data set describing object nodes and directional relationship edges between object nodes is used to enumerate the number of unique relationships pointing into an individual object node."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "node in-degree calculation"@en ; rdfs:subClassOf obo:OBI_0200129 . obo:OBI_0200133 obo:IAO_0000111 "node out-degree calculation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A node quality calculation in which an input data set describing object nodes and directional relationship edges between object nodes is used to enumerate the number of unique relationships pointing out of an individual object node."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "node out-degree calculation"@en ; rdfs:subClassOf obo:OBI_0200129 . obo:OBI_0200134 obo:IAO_0000111 "node shortest path identification"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A node quality calculation in which a path describing the shortest path needed to transverse through connected nodes and edges to arrive at a specific target node in the network."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "node shortest path identification"@en ; rdfs:subClassOf obo:OBI_0200129 . obo:OBI_0200135 obo:IAO_0000111 "edge quality calculation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A network analysis in which an input data set describing node objects and edge relationships between node objects is used to determine the output quality of one of the edge relationships in the network."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "edge quality calculation"@en ; rdfs:subClassOf obo:OBI_0200080 . obo:OBI_0200136 obo:IAO_0000111 "edge betweenness calculation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An edge quality calculation in which the input is a data sets of shortest paths between all pairs of node in the network and the output is the sum of all shortest paths that traverse the specific edge."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "edge betweenness calculation"@en ; rdfs:subClassOf obo:OBI_0200135 . obo:OBI_0200137 obo:IAO_0000111 "network subgraph quality calculation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A network analysis in which an input data set describing node objects and edge relationships between node objects is used to determine the output quality of a subgraph partition of the network."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "network subgraph quality calculation"@en ; rdfs:subClassOf obo:OBI_0200080 . obo:OBI_0200138 obo:IAO_0000111 "subgraph degree calculation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A network subgraph quality calculation in which an input data set describing subgraphs and relationship edges between subgraphs and other network objects is used to enumerate the number of unique relationships of an individual subgraph."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "subgraph degree calculation"@en ; rdfs:subClassOf obo:OBI_0200137 . obo:OBI_0200139 obo:IAO_0000111 "quantitative subgraph degree calculation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A network subgraph quality calculation in which an input data set describing subgraphs and quantitative relationship edges between subgraphs and other network objects is used to sum the quantitative relationships of an individual subgraph."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "quantitative subgraph degree calculation"@en ; rdfs:subClassOf obo:OBI_0200137 . obo:OBI_0200140 obo:IAO_0000111 "mathematical feature" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "feature is a (parent_class) that describes a characteristic, trait or quality of a data transformation"@en ; obo:IAO_0000116 "This class is temporary and will be placed outside of data transformation ultimately (if it still remains at all after review)"@en ; obo:IAO_0000117 "James Malone"@en ; obo:IAO_0000119 "PERSON: James Malone" ; a owl:Class ; rdfs:label "mathematical feature"@en ; rdfs:subClassOf obo:OBI_0200000 . obo:OBI_0200141 obo:IAO_0000111 "log base" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The log base is a feature of a logarithmic function which is defined in http://en.wikipedia.org/wiki/Logarithm. Its value can be any positive real number different from 1." ; obo:IAO_0000117 "Elisabetta Manduchi" ; obo:IAO_0000118 "logarithm base", "logarithmic base" ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Logarithm" ; a owl:Class ; rdfs:label "log base"@en ; rdfs:subClassOf obo:OBI_0200140, [ a owl:Restriction ; owl:onProperty obo:OBI_0000292 ; owl:someValuesFrom xsd:float ] . obo:OBI_0200143 obo:IAO_0000111 "subgraph in-degree calculation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A network subgraph quality calculation in which an input data set describing subgraphs and directional relationship edges between subgraphs and other network objects is used to enumerate the number of unique relationships pointing into an individual subgraph."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "subgraph in-degree calculation"@en ; rdfs:subClassOf obo:OBI_0200137 . obo:OBI_0200144 obo:IAO_0000111 "subgraph out-degree calculation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A network subgraph quality calculation in which an input data set describing subgraphs and relationship edges between subgraphs and other network objects is used to enumerate the number of unique relationships pointing out of an individual subgraph."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "subgraph out-degree calculation"@en ; rdfs:subClassOf obo:OBI_0200137 . obo:OBI_0200145 obo:IAO_0000111 "intra subgraph connectivity calculation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A network subgraph quality calculation in which an input data set describing internal nodes, edges and node degrees is used to determine the average node degree within the subgraph."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "intra subgraph connectivity calculation"@en ; rdfs:subClassOf obo:OBI_0200137 . obo:OBI_0200146 obo:IAO_0000111 "subgraph modularity calculation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A network subgraph quality calculation in which an input data set of subgraph in-degree and out-degree qualities is used to calculate the ratio of indegree to outdegree as a measure of modularity."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "subgraph modularity calculation"@en ; rdfs:subClassOf obo:OBI_0200137 . obo:OBI_0200147 obo:IAO_0000111 "network graph quality calculation"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A network analysis in which an input data set describing node objects and edge relationships between node objects is used to determine the output quality of the network as a whole."@en ; obo:IAO_0000117 "Richard Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard Scheuermann"@en ; a owl:Class ; rdfs:label "network graph quality calculation"@en ; rdfs:subClassOf obo:OBI_0200080 . obo:OBI_0200149 obo:IAO_0000111 "unit-variance scaling"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A unit-variance scaling is a data transformation that divides all measurements of a variable by the standard deviation of that variable."@en ; obo:IAO_0000117 "Elisabetta Manduchi"@en, "Philippe Rocca-Serra"@en ; obo:IAO_0000118 "autoscaling"@en ; obo:IAO_0000119 "PMID:16762068"@en ; a owl:Class ; rdfs:label "unit-variance scaling"@en ; rdfs:subClassOf obo:OBI_0200169, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] . obo:OBI_0200150 obo:IAO_0000111 "MA transformation" ; obo:IAO_0000112 "MA transformations are typically used in microarray data analyses. In this context, the g_i and r_i represent the reporter intensities in the two channels of a 2-channel assay or the reporter intensities in two related one-channel assays. Typically the base used for the logarithm is 2." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An MA transformation is a data transformation which takes as input a collection of data points (g_1, r_1), (g_2, r_2), ..., (g_n, r_n) with the r_i and g_i positive real numbers, and whose output is the collection of data points (A_1, M_1), (A_2, M_2), ..., (A_n, M_n) where, for each i, A_i=(log(g_i)+log(r_i))/2 and M_i=log(r_i)-log(g_i). Here log denotes a logarithmic transformation." ; obo:IAO_0000117 "Elisabetta Manduchi", "Philippe Rocca-Serra" ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi" ; a owl:Class ; rdfs:label "MA transformation" ; rdfs:subClassOf obo:OBI_0200000 . obo:OBI_0200151 obo:IAO_0000111 "exponential base" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The exponential base is a feature of an exponential function which is defined in http://en.wikipedia.org/wiki/Exponential_function. Its value can be any positive real number (typically different from 1)." ; obo:IAO_0000117 "Elisabetta Manduchi" ; obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Exponential_function" ; a owl:Class ; rdfs:label "exponential base"@en ; rdfs:subClassOf obo:OBI_0200140, [ a owl:Restriction ; owl:onProperty obo:OBI_0000292 ; owl:someValuesFrom xsd:float ] . obo:OBI_0200152 obo:IAO_0000111 "polynomial degree" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The polynomial degree is a feature of a polynomial function defined as the highest power of the polynomial's terms, where the terms of a polynomial are the individual summands with the coefficients omitted." ; obo:IAO_0000117 "Elisabetta Manduchi" ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi" ; a owl:Class ; rdfs:label "polynomial degree"@en ; rdfs:subClassOf obo:OBI_0200140, [ a owl:Restriction ; owl:onProperty obo:OBI_0000292 ; owl:someValuesFrom xsd:nonNegativeInteger ] . obo:OBI_0200153 obo:IAO_0000111 "number of variables" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "The number of variables is a feature of any function (including polynomial functions) with domain contained in an n-dimensional vector space and is defined as n, the dimension of such space." ; obo:IAO_0000117 "Elisabetta Manduchi" ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi" ; a owl:Class ; rdfs:label "number of variables"@en ; rdfs:subClassOf obo:OBI_0200140, [ a owl:Restriction ; owl:onProperty obo:OBI_0000292 ; owl:someValuesFrom xsd:integer ] . obo:OBI_0200154 obo:IAO_0000111 "agglomerative hierarchical clustering"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An agglomerative hierarchical clustering is a hierarchical clustering which starts with separate clusters and then successively combines these clusters until there is only one cluster remaining."@en ; obo:IAO_0000117 "Elisabetta Manduchi", "James Malone"@en ; obo:IAO_0000118 "bottom-up hierarchical clustering" ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en ; a owl:Class ; rdfs:label "agglomerative hierarchical clustering"@en ; rdfs:subClassOf obo:OBI_0200042 . obo:OBI_0200155 obo:IAO_0000111 "divisive hierarchical clustering"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A divisive hierarchical clustering is a hierarchical clustering which starts with a single cluster and then successively splits resulting clusters until only clusters of individual objects remain."@en ; obo:IAO_0000117 "Elisabetta Manduchi", "James Malone"@en ; obo:IAO_0000118 "top-down hierarchical clustering" ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi"@en ; a owl:Class ; rdfs:label "divisive hierarchical clustering"@en ; rdfs:subClassOf obo:OBI_0200042 . obo:OBI_0200156 obo:IAO_0000111 "data partitioning"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Data partitioning is a data transformation with the objective of partitioning or separating input data into output subsets."@en ; obo:IAO_0000117 "James Malone"@en ; obo:IAO_0000119 "PERSON: Melanie Courtot"@en, "PERSON: Richard Scheuermann"@en, "PERSON: Ryan Brinkman"@en ; a owl:Class ; rdfs:label "data partitioning"@en ; rdfs:subClassOf obo:OBI_0200000 . obo:OBI_0200157 obo:IAO_0000111 "data vector reduction objective"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Data vector reduction is a data transformation objective in which k m-dimensional input vectors are reduced to j m-dimensional output vectors, where j is smaller than k."@en ; obo:IAO_0000117 "James Malone", "Richard H. Scheuermann"@en ; obo:IAO_0000119 "PERSON: Richard H. Scheuermann"@en ; a owl:Class ; rdfs:label "data vector reduction objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0200160 obo:IAO_0000111 "generalized family wise error rate correction method"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A generalized FWER correction method is a multiple testing procedure that controls the probability of at least k+1 false positives, where k is a user-supplied integer." ; obo:IAO_0000117 "Monnie McGee" ; obo:IAO_0000118 "gFWER correction"@en ; obo:IAO_0000119 "Dudoit, Sandrine and van der Laan, Mark J. (2008) Multiple Testing Procedures with Applications to Genomics. New York: Springer , p. 19" ; a owl:Class ; rdfs:label "generalized family wise error rate correction method"@en ; rdfs:subClassOf obo:OBI_0200089, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000791 ] . obo:OBI_0200161 obo:IAO_0000111 "quantile number of false positives correction method"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A quantile number of false positives correction method is a MTP that controls for the pth quantile of the distribution of the number of false positives out of the total number of tests performed'" ; obo:IAO_0000117 "Monnie McGee" ; obo:IAO_0000118 "QNFP"@en ; obo:IAO_0000119 "Dudoit, Sandrine and van der Laan, Mark J. (2008) Multiple Testing Procedures with Applications to Genomics. New York: Springer , p. 19" ; a owl:Class ; rdfs:label "quantile number of false positives correction method"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200089, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000662 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000791 ] ) ] . obo:OBI_0200162 obo:IAO_0000111 "tail probability for the proportion of false positives correction method"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A TPPFP correction method is a MTP that controls the probability that the proportion of false positives among all rejected hypotheses is no greater than a constant q, where q is between 0 and 1." ; obo:IAO_0000117 "Monnie McGee" ; obo:IAO_0000118 "TPPFP correction method"@en ; obo:IAO_0000119 "Dudoit, Sandrine and van der Laan, Mark J. (2008) Multiple Testing Procedures with Applications to Genomics. New York: Springer , p. 20" ; a owl:Class ; rdfs:label "tail probability for the proportion of false positives correction method"@en ; rdfs:subClassOf obo:OBI_0200089, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000791 ] . obo:OBI_0200163 obo:IAO_0000111 "false discovery rate correction method"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "The false discovery rate is a data transformation used in multiple hypothesis testing to correct for multiple comparisons. It controls the expected proportion of incorrectly rejected null hypotheses (type I errors) in a list of rejected hypotheses. It is a less conservative comparison procedure with greater power than familywise error rate (FWER) control, at a cost of increasing the likelihood of obtaining type I errors. ." ; obo:IAO_0000116 """2011-03-31: [PRS]. creating a defined class by specifying the necessary output of dt allows correct classification of FDR dt"""@en ; obo:IAO_0000117 "Monnie McGee", "Philippe Rocca-Serra"@en ; obo:IAO_0000118 "FDR correction method"@en ; obo:IAO_0000119 "Dudoit, Sandrine and van der Laan, Mark J. (2008) Multiple Testing Procedures with Applications to Genomics. New York: Springer , p. 21 and http://www.wikidoc.org/index.php/False_discovery_rate" ; a owl:Class ; rdfs:label "false discovery rate correction method"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200089, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000175 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000791 ] ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001442 ] . obo:OBI_0200164 obo:IAO_0000111 "proportion of expected false positives correction method"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A proportion of expected false positives correction method is a multiple testing procedure that controls the ratio of the expected value of the numbers of false positives to the expected value of the numbers of rejected hypotheses." ; obo:IAO_0000117 "Monnie McGee" ; obo:IAO_0000118 "PEFP correction method"@en ; obo:IAO_0000119 "Dudoit, Sandrine and van der Laan, Mark J. (2008) Multiple Testing Procedures with Applications to Genomics. New York: Springer , p. 21" ; a owl:Class ; rdfs:label "proportion of expected false positives correction method"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200089, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000662 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000791 ] ) ] . obo:OBI_0200165 obo:IAO_0000111 "quantile proportion of false positives correction method"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A quantile proportion of false positives correction method is a multiple testing procedure that controls the pth quantile of the distribution of the proportion of false positives among the rejected hypothesis (false discovery rate)." ; obo:IAO_0000117 "Monnie McGee" ; obo:IAO_0000118 "QPFP correction method"@en ; obo:IAO_0000119 "Dudoit, Sandrine and van der Laan, Mark J. (2008) Multiple Testing Procedures with Applications to Genomics. New York: Springer , p. 21" ; a owl:Class ; rdfs:label "quantile proportion of false positives correction method"@en ; rdfs:subClassOf obo:APOLLO_SV_00000796, obo:OBI_0200089, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000662 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000791 ] ) ] . obo:OBI_0200166 obo:IAO_0000111 "data transformation objective"@en ; obo:IAO_0000112 "normalize objective"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An objective specification to transformation input data into output data"@en ; obo:IAO_0000116 "Modified definition in 2013 Philly OBI workshop" ; obo:IAO_0000117 "James Malone"@en ; obo:IAO_0000119 "PERSON: James Malone"@en ; a owl:Class ; rdfs:label "data transformation objective"@en ; rdfs:subClassOf obo:IAO_0000005 . obo:OBI_0200167 obo:IAO_0000111 "data normalization objective"@en ; obo:IAO_0000112 "Quantile transformation which has normalization objective can be used for expression microarray assay normalization and it is referred to as \"quantile normalization\", according to the procedure described e.g. in PMID 12538238."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 """A normalization objective is a data transformation objective where the aim is to remove systematic sources of variation to put the data on equal footing in order to create a common base for comparisons."""@en ; obo:IAO_0000117 "Elisabetta Manduchi", "Helen Parkinson", "James Malone"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi", "PERSON: Helen Parkinson", "PERSON: James Malone"@en ; a owl:Class ; rdfs:label "data normalization objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0200168 obo:IAO_0000111 "correction objective"@en ; obo:IAO_0000112 "Type I error correction"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A correction objective is a data transformation objective where the aim is to correct for error, noise or other impairments to the input of the data transformation or derived from the data transformation itself"@en ; obo:IAO_0000117 "James Malone"@en ; obo:IAO_0000119 "PERSON: James Malone", "PERSON: Melanie Courtot" ; a owl:Class ; rdfs:label "correction objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0200169 obo:IAO_0000111 "normalization data transformation"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A normalization data transformation is a data transformation that has objective normalization."@en ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "PERSON: James Malone"@en ; a owl:Class ; rdfs:label "normalization data transformation"@en ; rdfs:subClassOf obo:OBI_0200000 ; owl:equivalentClass [ a owl:Class ; owl:unionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000451 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200167 ] ) ] . obo:OBI_0200170 obo:IAO_0000111 "averaging data transformation"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An averaging data transformation is a data transformation that has objective averaging."@en ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "PERSON: James Malone"@en ; a owl:Class ; rdfs:label "averaging data transformation"@en ; rdfs:subClassOf obo:OBI_0200000 ; owl:equivalentClass [ a owl:Class ; owl:unionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000679 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000425 ] ) ] . obo:OBI_0200171 obo:IAO_0000111 "partitioning data transformation"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A partitioning data transformation is a data transformation that has objective partitioning."@en ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "PERSON: James Malone"@en ; a owl:Class ; rdfs:label "partitioning data transformation"@en ; rdfs:subClassOf obo:OBI_0200000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200172 ] . obo:OBI_0200172 obo:IAO_0000111 "partitioning objective"@en ; obo:IAO_0000112 "A k-means clustering which has partitioning objective is a data transformation in which the input data is partitioned into k output sets."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A partitioning objective is a data transformation objective where the aim is to generate a collection of disjoint non-empty subsets whose union equals a non-empty input set."@en ; obo:IAO_0000117 "Elisabetta Manduchi", "James Malone"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi" ; a owl:Class ; rdfs:label "partitioning objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0200173 obo:IAO_0000111 "background correction objective"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A background correction objective is a data transformation objective where the aim is to remove irrelevant contributions from the measured signal, e.g. those due to instrument noise or sample preparation."@en ; obo:IAO_0000117 "Elisabetta Manduchi", "James Malone"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi" ; a owl:Class ; rdfs:label "background correction objective"@en ; rdfs:subClassOf obo:OBI_0200168 . obo:OBI_0200174 obo:IAO_0000111 "curve fitting objective"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A curve fitting objective is a data transformation objective in which the aim is to find a curve which matches a series of data points and possibly other constraints."@en ; obo:IAO_0000117 "Elisabetta Manduchi", "James Malone"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi" ; a owl:Class ; rdfs:label "curve fitting objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0200175 obo:IAO_0000111 "class discovery data transformation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A class discovery data transformation (sometimes called unsupervised classification) is a data transformation that has objective class discovery."@en ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000118 "clustering data transformation", "unsupervised classification data transformation" ; obo:IAO_0000119 "PERSON: James Malone"@en ; a owl:Class ; rdfs:label "class discovery data transformation"@en ; rdfs:subClassOf obo:OBI_0200000 ; owl:equivalentClass [ a owl:Class ; owl:unionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000648 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200178 ] ) ] . obo:OBI_0200176 obo:IAO_0000111 "Fisher's exact test" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Fisher's exact test is a data transformation used to determine if there are nonrandom associations between two Fisher's exact test is a statistical significance test used in the analysis of contingency tables where sample sizes are small where the significance of the deviation from a null hypothesis can be calculated exactly, rather than relying on an approximation that becomes exact in the limit as the sample size grows to infinity, as with many statistical tests." ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "WEB:http://mathworld.wolfram.com/FishersExactTest.html" ; a owl:Class ; rdfs:label "Fisher's exact test" ; rdfs:subClassOf obo:OBI_0000673, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000675 ] . obo:OBI_0200177 obo:IAO_0000111 "center calculation objective"@en ; obo:IAO_0000112 "A mean calculation which has center calculation objective is a data transformation in which the center of the input data is discovered through the calculation of a mean average."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A center calculation objective is a data transformation objective where the aim is to calculate the center of an input data set."@en ; obo:IAO_0000117 "James Malone"@en ; obo:IAO_0000119 "PERSON: James Malone" ; a owl:Class ; rdfs:label "center calculation objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0200178 obo:IAO_0000111 "class discovery objective"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A class discovery objective (sometimes called unsupervised classification) is a data transformation objective where the aim is to organize input data (typically vectors of attributes) into classes, where the number of classes and their specifications are not known a priori. Depending on usage, the class assignment can be definite or probabilistic."@en ; obo:IAO_0000117 "James Malone"@en ; obo:IAO_0000118 "clustering objective", "discriminant analysis objective"@en, "unsupervised classification objective"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi", "PERSON: James Malone" ; a owl:Class ; rdfs:label "class discovery objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0200179 obo:IAO_0000111 "class prediction objective"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 """A class prediction objective (sometimes called supervised classification) is a data transformation objective where the aim is to create a predictor from training data through a machine learning technique. The training data consist of pairs of objects (typically vectors of attributes) and class labels for these objects. The resulting predictor can be used to attach class labels to any valid novel input object. Depending on usage, the prediction can be definite or probabilistic. A classification is learned from the training data and can then be tested on test data."""@en ; obo:IAO_0000117 "James Malone"@en ; obo:IAO_0000118 "classification objective", "supervised classification objective"@en ; obo:IAO_0000119 "PERSON: Elisabetta Manduchi", "PERSON: James Malone" ; a owl:Class ; rdfs:label "class prediction objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0200180 obo:IAO_0000111 "spread calculation objective"@en ; obo:IAO_0000112 "Spread calculation can be achieved by use of a standard deviation, which measures distance from the mean" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is a data transformation objective whereby the aim is to the calculate the spread of a dataset, spread is a descriptive statistic which describes the variability of values in a data set." ; obo:IAO_0000116 "Awaiting English definition from Monnie McGee"@en ; obo:IAO_0000117 "James Malone"@en, "Person:Helen Parkinson" ; a owl:Class ; rdfs:label "spread calculation objective"@en ; rdfs:subClassOf obo:OBI_0200166 . obo:OBI_0200181 obo:IAO_0000111 "center calculation data transformation"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A center calculation data transformation is a data transformation that has objective of center calculation."@en ; obo:IAO_0000117 "James Malone" ; obo:IAO_0000119 "PERSON: James Malone"@en ; a owl:Class ; rdfs:label "center calculation data transformation"@en ; rdfs:subClassOf obo:OBI_0200000 ; owl:equivalentClass [ a owl:Class ; owl:unionOf ([ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000674 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0200177 ] ) ] . obo:OBI_0200182 obo:IAO_0000111 "data vector reduction data transformation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A data vector reduction is a data transformation that has objective data vector reduction and that consists of reducing the input vectors k to a smaller number of output vectors j, where j@2008/03/03" ; a owl:Class ; rdfs:label "DNA microarray" ; rdfs:subClassOf obo:OBI_0400147 . obo:OBI_0400149 obo:IAO_0000111 "protein microarray" ; obo:IAO_0000112 "The most common protein microarray is the antibody microarray, where antibodies are spotted onto the protein chip and are used as capture molecules to detect proteins from cell lysate solutions." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A protein-microarray is a microarray, ususlly a piece of glass, on which different molecules of protein have been affixed at separate locations in an ordered manner. These are used to identify protein-protein or protein-small molecule interactions." ; obo:IAO_0000117 "Daniel Schober" ; obo:IAO_0000119 "PERSON: Daniel Schober" ; a owl:Class ; rdfs:label "protein microarray" ; rdfs:subClassOf obo:OBI_0400147 . obo:OBI_0400153 obo:IAO_0000111 "droplet sorter" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A droplet sorter is part_of a flow cytometer sorter that converts the carrier fluid stream into individual droplets, and these droplets are directed into separate locations for recovery (enriching the original sample for particles of interest based on qualities determined by gating) or disposal." ; obo:IAO_0000117 "OBI Instrument branch" ; obo:IAO_0000119 "OBI Instrument branch" ; a owl:Class ; rdfs:label "droplet sorter" ; rdfs:subClassOf obo:OBI_0000932, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000403 ] . obo:OBI_0400155 obo:IAO_0000111 "water bath" ; obo:IAO_0000112 "A water bath was used to allow for cell incubation at 38 degree centigrade for 8 hours." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A water bath is a temperature control bath in which a water acts as contact medium enabling temperature transfer from the heating element or cooling element to the sample. The temperature can be controlled in the 0 to 100 degree centigrade range (under normal pressure)." ; obo:IAO_0000117 "Daniel Schober" ; obo:IAO_0000119 "PERSON: Daniel Schober" ; a owl:Class ; rdfs:label "water bath" ; rdfs:subClassOf obo:OBI_0400120 . obo:OBI_0400157 obo:IAO_0000111 "oil bath" ; obo:IAO_0000112 "An oil bath was used to allow for fast reaction of two chemical compounds during a 2 hour period." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An oil bath is a temperature control bath in which oil acts as contact medium for the temperature transfer (from heating or cooling elements to the sample)." ; obo:IAO_0000117 "Daniel Schober" ; obo:IAO_0000119 "PERSON: Daniel Schober" ; a owl:Class ; rdfs:label "oil bath" ; rdfs:subClassOf obo:OBI_0400120 . obo:OBI_0400158 obo:IAO_0000111 "digital-to-analog converter" ; obo:IAO_0000112 "A digital-to-analog_converter is used to convert a computergenerated discrete signal into a continuous analog one, e.g. a sound." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A digital-to-analog_converter is an instrument that converts a finite resolution digital signal into an infinite resolution analog signal." ; obo:IAO_0000117 "Daniel Schober" ; obo:IAO_0000119 "PERSON: Daniel Schober" ; a owl:Class ; rdfs:label "digital-to-analog converter" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000393 ] . obo:OBI_0400168 obo:IAO_0000111 "microtome" ; obo:IAO_0000112 "PMID: 9974145.Serial sectioning of thick tissue with a novel vibrating blade microtome. Brain Res Brain Res Protoc. 1999 Jan;3(3):302-7." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A microtome is a mechanical instrument used to cut biological specimens into very thin segments for further treatment (e.g. ISH) and ultimately microscopic or histologic examination. Most microtomes provide cooling facilities (cryo-microtome) and use a steel blade to cut a slice of defined thickness. Some are automatic, and some are driven by hand." ; obo:IAO_0000117 "PERSON: Phillippe Rocca-Serra" ; obo:IAO_0000119 "PERSON: Daniel Schober" ; a owl:Class ; rdfs:label "microtome" ; rdfs:subClassOf obo:OBI_0000932, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000372 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000379 ] . obo:OBI_0400169 obo:IAO_0000111 "microscope" ; obo:IAO_0000112 "PMID:18466942. A light and transmission electron microscope study of hepatic portal tracts in the rhesus monkey (Macacus rhesus). Tissue Cell. 2008 May 6" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A microscope is an instrument which magnifies the view on objects (too small to be viewed by the naked eye) under increased resolution. A microscope can be an optical instrument but also and electronic instrument. There are various kind of optical microscopes, e.g confocal microscope, epifluoresence microscope)" ; obo:IAO_0000117 "PERSON: Phillippe Rocca-Serra" ; obo:IAO_0000119 "wikipedia" ; a owl:Class ; rdfs:label "microscope" ; rdfs:subClassOf obo:OBI_0000398, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000369 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000397 ] . obo:OBI_0400170 obo:IAO_0000111 "microscope slide" ; obo:IAO_0000112 "PMID: 9668975.Microscope slide for enhanced analysis of DNA damage using the comet assay." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A microscope slide is a device usually made of glass which is used as a solid matrix for (biological) material deposited on its surface and which is compatible for use with a microscope instrument" ; obo:IAO_0000117 "PERSON: Phillippe Rocca-Serra" ; obo:IAO_0000119 "OBI biomaterial branch" ; a owl:Class ; rdfs:label "microscope slide" ; rdfs:subClassOf obo:OBI_0000968, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000399 ] . obo:OBI_0400171 obo:IAO_0000111 "animal cage" ; obo:IAO_0000112 "PMID: 18246864.Barthold SW.Effects of cage density on behavior in young adult mice." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A processed material which has the function to define a bounded habitat which is amenable to keeping animals." ; obo:IAO_0000117 "PERSON: Phillippe Rocca-Serra" ; obo:IAO_0000118 "laboratory cage" ; obo:IAO_0000119 "OBI biomaterial branch" ; a owl:Class ; rdfs:label "animal cage" ; rdfs:subClassOf obo:OBI_0000967, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_0000370 ] . obo:OBI_0500000 obo:IAO_0000111 "study design"@en ; obo:IAO_0000112 "a matched pairs study design describes criteria by which subjects are identified as pairs which then undergo the same protocols, and the data generated is analyzed by comparing the differences between the paired subjects, which constitute the results of the executed study design."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A plan specification comprised of protocols (which may specify how and what kinds of data will be gathered) that are executed as part of an investigation and is realized during a study design execution." ; obo:IAO_0000116 "Editor note: there is at least an implicit restriction on the kind of data transformations that can be done based on the measured data available." ; obo:IAO_0000117 "PERSON: Chris Stoeckert" ; obo:IAO_0000118 "experimental design"@en ; obo:IAO_0000232 "rediscussed at length (MC/JF/BP). 12/9/08). The definition was clarified to differentiate it from protocol."@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "study design"@en ; rdfs:subClassOf obo:IAO_0000104, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000272 ] . obo:OBI_0500001 obo:IAO_0000111 "clinical study design" ; obo:IAO_0000112 "PMID: 17655677.J Cardiovasc Electrophysiol. 2007 Aug;18(9):965-71.Biventricular versus right ventricular pacing in patients with AV block (BLOCK HF): clinical study design and rationale." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Plan for the precise procedure to be followed in a clinical trial, including planned and actual timing of events, choice of control group, method of allocating treatments, blinding methods; assigns a subject to pass through one or more epochs in the course of a trial. Specific design elements, e.g., crossover, parallel; dose-escalation [Modified from Pocock, Clinical Trials: A Practical Approach]" ; obo:IAO_0000116 "The definition needs to be extended to other things than simply patients" ; obo:IAO_0000117 "PlanAndPlannedProcess Branch" ; obo:IAO_0000119 "Clinical Research Glossary Version 4.0 CDICS glossary group" ; a owl:Class ; rdfs:label "clinical study design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0500002 obo:IAO_0000111 "repeated measure design" ; obo:IAO_0000112 "PMID: 10959922.J Biopharm Stat. 2000 Aug;10(3):433-45.Equivalence in test assay method comparisons for the repeated-measure, matched-pair design in medical device studies: statistical considerations." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a study design which use the same individuals and exposure them to a set of conditions. The effect of order and practice can be confounding factor in such designs" ; obo:IAO_0000117 "PlanAndPlannedProcess Branch" ; obo:IAO_0000119 "http://www.holah.karoo.net/experimentaldesigns.htm" ; a owl:Class ; rdfs:label "repeated measure design" ; rdfs:subClassOf obo:OBI_0000115 . obo:OBI_0500003 obo:IAO_0000111 "cross over design" ; obo:IAO_0000112 "PMID: 17601993-Objective: HIV-infected patients with lipodystrophy (HIV-lipodystrophy) are insulin resistant and have elevated plasma free fatty acid (FFA) concentrations. We aimed to explore the mechanisms underlying FFA-induced insulin resistance in patients with HIV-lipodystrophy. Research Design and Methods: Using a randomized placebo-controlled cross-over design, we studied the effects of an overnight acipimox-induced suppression of FFA on glucose and FFA metabolism by using stable isotope labelled tracer techniques during basal conditions and a two-stage euglycemic, hyperinsulinemic clamp (20 mU insulin/m(2)/min; 50 mU insulin/m(2)/min) in nine patients with nondiabetic HIV-lipodystrophy. All patients received antiretroviral therapy. Biopsies from the vastus lateralis muscle were obtained during each stage of the clamp. Results: Acipimox treatment reduced basal FFA rate of appearance by 68.9% (52.6%-79.5%) and decreased plasma FFA concentration by 51.6 % (42.0%-58.9%), (both, P < 0.0001). Endogenous glucose production was not influenced by acipimox. During the clamp the increase in glucose-uptake was significantly greater after acipimox treatment compared to placebo (acipimox: 26.85 (18.09-39.86) vs placebo: 20.30 (13.67-30.13) mumol/kg/min; P < 0.01). Insulin increased phosphorylation of Akt (Thr(308)) and GSK-3beta (Ser(9)), decreased phosphorylation of glycogen synthase (GS) site 3a+b and increased GS-activity (I-form) in skeletal muscle (P < 0.01). Acipimox decreased phosphorylation of GS (site 3a+b) (P < 0.02) and increased GS-activity (P < 0.01) in muscle. Conclusion: The present study provides direct evidence that suppression of lipolysis in patients with HIV-lipodystrophy improves insulin-stimulated peripheral glucose-uptake. The increased glucose-uptake may in part be explained by increased dephosphorylation of GS (site 3a+b) resulting in increased GS activity." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a repeated measure design which ensures that experimental units receive, in sequence, the treatment (or the control), and then, after a specified time interval (aka *wash-out periods*), switch to the control (or treatment). In this design, subjects (patients in human context) serve as their own controls, and randomization may be used to determine the ordering which a subject receives the treatment and control" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "(source: http://www.sbu.se/Filer/Content0/publikationer/1/literaturesearching_1993/glossary.html)" ; a owl:Class ; rdfs:label "cross over design" ; rdfs:subClassOf obo:OBI_0500002 . obo:OBI_0500004 obo:IAO_0000111 "n-to-1 design" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "N-of-1 design is a cross-over design in which the same patient is repeatedly randomised to receive either the experimental treatment or its control (Senn, 1993)." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "Adapted from http://www.childrens-mercy.org/stats/definitions/crossover.htm and source:http://symptomresearch.nih.gov/chapter_6/sec1/csss1pg1.htm)" ; a owl:Class ; rdfs:label "n-to-1 design" ; rdfs:subClassOf obo:OBI_0500003 . obo:OBI_0500005 obo:IAO_0000111 "matched pairs design" ; obo:IAO_0000112 "PMID: 17288613-BSTRACT: BACKGROUND: Physicians in Canadian emergency departments (EDs) annually treat 185,000 alert and stable trauma victims who are at risk for cervical spine (C-spine) injury. However, only 0.9% of these patients have suffered a cervical spine fracture. Current use of radiography is not efficient. The Canadian C-Spine Rule is designed to allow physicians to be more selective and accurate in ordering C-spine radiography, and to rapidly clear the C-spine without the need for radiography in many patients. The goal of this phase III study is to evaluate the effectiveness of an active strategy to implement the Canadian C-Spine Rule into physician practice. Specific objectives are to: 1) determine clinical impact, 2) determine sustainability, 3) evaluate performance, and 4) conduct an economic evaluation. METHODS: We propose a matched-pair cluster design study that compares outcomes during three consecutive 12-months before, after, and decay periods at six pairs of intervention and control sites. These 12 hospital ED sites will be stratified as teaching or community hospitals, matched according to baseline C-spine radiography ordering rates, and then allocated within each pair to either intervention or control groups. During the after period at the intervention sites, simple and inexpensive strategies will be employed to actively implement the Canadian C-Spine Rule. The following outcomes will be assessed: 1) measures of clinical impact, 2) performance of the Canadian C-Spine Rule, and 3) economic measures. During the 12-month decay period, implementation strategies will continue, allowing us to evaluate the sustainability of the effect. We estimate a sample size of 4,800 patients in each period in order to have adequate power to evaluate the main outcomes. DISCUSSION: Phase I successfully derived the Canadian C-Spine Rule and phase II confirmed the accuracy and safety of the rule, hence, the potential for physicians to improve care. What remains unknown is the actual change in clinical behaviors that can be affected by implementation of the Canadian C-Spine Rule, and whether implementation can be achieved with simple and inexpensive measures. We believe that the Canadian C-Spine Rule has the potential to significantly reduce health care costs and improve the efficiency of patient flow in busy Canadian EDs." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A matched pair design is a study design which use groups of individuals associated (hence matched) to each other based on a set of criteria, one member going to one treatment, the other member receiving the other treatment." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "http://www.holah.karoo.net/experimentaldesigns.htm" ; a owl:Class ; rdfs:label "matched pairs design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0500006 obo:IAO_0000111 "parallel group design" ; obo:IAO_0000112 "PMID: 17408389-Purpose: Proliferative vitreoretinopathy (PVR) is the most important reason for blindness following retinal detachment. Presently, vitreous tamponades such as gas or silicone oil cannot contact the lower part of the retina. A heavier-than-water tamponade displaces the inflammatory and PVR-stimulating environment from the inferior area of the retina. The Heavy Silicone Oil versus Standard Silicone Oil Study (HSO Study) is designed to answer the question of whether a heavier-than-water tamponade improves the prognosis of eyes with PVR of the lower retina. Methods: The HSO Study is a multicentre, randomized, prospective controlled clinical trial comparing two endotamponades within a two-arm parallel group design. Patients with inferiorly and posteriorly located PVR are randomized to either heavy silicone oil or standard silicone oil as a tamponading agent. Three hundred and fifty consecutive patients are recruited per group. After intraoperative re-attachment, patients are randomized to either standard silicone oil (1000 cSt or 5000 cSt) or Densiron((R)) as a tamponading agent. The main endpoint criteria are complete retinal attachment at 12 months and change of visual acuity (VA) 12 months postoperatively compared with the preoperative VA. Secondary endpoints include complete retinal attachment before endotamponade removal, quality of life analysis and the number of retina affecting re-operation within 1 year of follow-up. Results: The design and early recruitment phase of the study are described. Conclusions: The results of this study will uncover whether or not heavy silicone oil improves the prognosis of eyes with PVR." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A parallel group design or independent measure design is a study design which uses unique experimental unit each experimental group, in other word no two individuals are shared between experimental groups, hence also known as parallel group design. Subjects of a treatment group receive a unique combination of independent variable values making up a treatment" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000118 "independent measure design" ; obo:IAO_0000119 "http://www.holah.karoo.net/experimentaldesigns.htm" ; a owl:Class ; rdfs:label "parallel group design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0500007 obo:IAO_0000111 "randomized complete block design" ; obo:IAO_0000112 "http://www.stats.gla.ac.uk/steps/glossary/anova.html,(A researcher is carrying out a study of the effectiveness of four different skin creams for the treatment of a certain skin disease. He has eighty subjects and plans to divide them into 4 treatment groups of twenty subjects each. Using a randomised blocks& design, the subjects are assessed and put in blocks of four according to how severe their skin condition is; the four most severe cases are the first block, the next four most severe cases are the second block, and so on to the twentieth block. The four &members of each block are then randomly assigned, one to each of the four treatment groups. http://www.stats.gla.ac.uk/steps/glossary/anova.html#rbd))" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A randomized complete block design is_a study design which assigns randomly treatments to block. The number of units per block equals the number of treatment so each block receives each treatment exactly once (hence the qualifier 'complete'). The design was originally devised from field trials used in agronomy and agriculture. The analysis assumes that there is no interaction between block and treatment. The method was then used in other settings So The randomised complete block design is a design in which the subjects are matched according to a variable which the experimenter wishes to control. The subjects are put into groups (blocks) of the same size as the number of treatments. The members of each block are then randomly assigned to different treatment groups." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "http://www.tufts.edu/~gdallal/ranblock.htm" ; a owl:Class ; rdfs:label "randomized complete block design" ; rdfs:subClassOf obo:OBI_0000115 . obo:OBI_0500008 obo:IAO_0000111 "balanced incomplete block design" ; obo:IAO_0000112 "PMID: 7622388.Health Educ Q. 1995 May;22(2):201-10.Balanced incomplete block design: description, case study, and implications for practice." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "balanced incomplete block design is a kind of factorial design where all treatment pairs occur together within a block an equal number ?? times. ??ii' is the number of times treatment i occurs with i'" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Block_design and http://www.stat.psu.edu/~jglenn/stat503/05_factorial/02_factorial_IBD.html" ; a owl:Class ; rdfs:label "balanced incomplete block design" ; rdfs:subClassOf obo:OBI_0500014 . obo:OBI_0500009 obo:IAO_0000111 "loop design" ; obo:IAO_0000112 "PMID: 12933549" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A loop experiment design is where labeled extracts are compared in consecutive pairs. synonym: circular design" ; obo:IAO_0000117 "Philippe Rocca-Serra on behalf of MO" ; obo:IAO_0000119 "MO_912" ; a owl:Class ; rdfs:label "loop design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0500010 obo:IAO_0000111 "reference design" ; obo:IAO_0000112 "PMID: 12933549" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A reference experiment design type is where all samples are compared to a common reference." ; obo:IAO_0000117 "Philippe Rocca-Serra on behalf of MO" ; obo:IAO_0000119 "MO_699" ; a owl:Class ; rdfs:label "reference design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0500011 obo:IAO_0000111 "latin square design" ; obo:IAO_0000112 "PMID: 17582121-Our objective was to examine the effects of dietary cation-anion difference (DCAD) with different concentrations of dietary crude protein (CP) on performance and acid-base status in early lactation cows. Six lactating Holstein cows averaging 44 d in milk were used in a 6 x 6 Latin square design with a 2 x 3 factorial arrangement of treatments: DCAD of -3, 22, or 47 milliequivalents (Na + K - Cl - S)/100 g of dry matter (DM), and 16 or 19% CP on a DM basis. Linear increases with DCAD occurred in DM intake, milk fat percentage, 4% fat-corrected milk production, milk true protein, milk lactose, and milk solids-not-fat. Milk production itself was unaffected by DCAD. Jugular venous blood pH, base excess and HCO3(-) concentration, and urine pH increased, but jugular venous blood Cl- concentration, urine titratable acidity, and net acid excretion decreased linearly with increasing DCAD. An elevated ratio of coccygeal venous plasma essential AA to nonessential AA with increasing DCAD indicated that N metabolism in the rumen was affected, probably resulting in more microbial protein flowing to the small intestine. Cows fed 16% CP had lower urea N in milk than cows fed 19% CP; the same was true for urea N in coccygeal venous plasma and urine. Dry matter intake, milk production, milk composition, and acid-base status did not differ between the 16 and 19% CP treatments. It was concluded that DCAD affected DM intake and performance of dairy cows in early lactation. Feeding 16% dietary CP to cows in early lactation, compared with 19% CP, maintained lactation performance while reducing urea N excretion in milk and urine." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Latin square design is_a study design which allows in its simpler form controlling 2 levels of nuisance variables (also known as blocking variables).he 2 nuisance factors are divided into a tabular grid with the property that each row and each column receive each treatment exactly once." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "Adapted from: http://www.itl.nist.gov/div898/handbook/pri/section3/pri3321.htm and" ; a owl:Class ; rdfs:label "latin square design" ; rdfs:subClassOf obo:OBI_0500007 . obo:OBI_0500012 obo:IAO_0000111 "graeco latin square design" ; obo:IAO_0000112 "PMID: 6846242-Beaton et al (Am J Clin Nutr 1979;32:2546-59) reported on the partitioning of variance in 1-day dietary data for the intake of energy, protein, total carbohydrate, total fat, classes of fatty acids, cholesterol, and alcohol. Using the same food intake data and the expanded National Heart, Lung and Blood Institute food composition data base, these analyses of sources of variance have been expanded to include classes of carbohydrate, vitamin A, vitamin C, thiamin, riboflavin, niacin, calcium, iron, total ash, caffeine, and crude fiber. The analyses relate to observed intakes (replicated six times) of 30 adult males and 30 adult females obtained under a paired Graeco-Latin square design with sequence of interview, interviewer, and day of the week as determinants. Neither sequence nor interviewer made consistent contribution to variance. In females, day of the week had a significant effect for several nutrients. The major partitioning of variance was between interindividual variation (between subjects) and intraindividual variation (within subjects) which included both true day-to-day variation in intake and methodological variation. For all except caffeine, the intraindividual variability of 1-day data was larger than the interindividual variability. For vitamin A, almost all of the variance was associated with day-to-day variability. One day data provide a very inadequate estimate of usual intake of individuals. In the design of nutrition studies it is critical that the intended use of dietary data be a major consideration in deciding on methodology. There is no ideal dietary method. There may be preferred methods for particular purposes." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Greco-Latin square design is a study design which relates to Latin square design" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "Adapted from: http://www.itl.nist.gov/div898/handbook/pri/section3/pri3321.htm and" ; obo:IAO_0000232 "only 2 articles in pubmed ->probably irrelevant" ; a owl:Class ; rdfs:label "graeco latin square design" ; rdfs:subClassOf obo:OBI_0500007 . obo:OBI_0500013 obo:IAO_0000111 "hyper graeco latin square design" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "PRS to do" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "Adapted from: http://www.itl.nist.gov/div898/handbook/pri/section3/pri3321.htm and" ; obo:IAO_0000232 "no example found in pubmed->not in use in the community" ; a owl:Class ; rdfs:label "hyper graeco latin square design" ; rdfs:subClassOf obo:OBI_0500007 . obo:OBI_0500014 obo:IAO_0000111 "factorial design" ; obo:IAO_0000112 "PMID: 17582121-Our objective was to examine the effects of dietary cation-anion difference (DCAD) with different concentrations of dietary crude protein (CP) on performance and acid-base status in early lactation cows. Six lactating Holstein cows averaging 44 d in milk were used in a 6 x 6 Latin square design with a 2 x 3 factorial arrangement of treatments: DCAD of -3, 22, or 47 milliequivalents (Na + K - Cl - S)/100 g of dry matter (DM), and 16 or 19% CP on a DM basis. Linear increases with DCAD occurred in DM intake, milk fat percentage, 4% fat-corrected milk production, milk true protein, milk lactose, and milk solids-not-fat. Milk production itself was unaffected by DCAD. Jugular venous blood pH, base excess and HCO3(-) concentration, and urine pH increased, but jugular venous blood Cl- concentration, urine titratable acidity, and net acid excretion decreased linearly with increasing DCAD. An elevated ratio of coccygeal venous plasma essential AA to nonessential AA with increasing DCAD indicated that N metabolism in the rumen was affected, probably resulting in more microbial protein flowing to the small intestine. Cows fed 16% CP had lower urea N in milk than cows fed 19% CP; the same was true for urea N in coccygeal venous plasma and urine. Dry matter intake, milk production, milk composition, and acid-base status did not differ between the 16 and 19% CP treatments. It was concluded that DCAD affected DM intake and performance of dairy cows in early lactation. Feeding 16% dietary CP to cows in early lactation, compared with 19% CP, maintained lactation performance while reducing urea N excretion in milk and urine." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "factorial design is_a study design which is used to evaluate two or more factors simultaneously. The treatments are combinations of levels of the factors. The advantages of factorial designs over one-factor-at-a-time experiments is that they are more efficient and they allow interactions to be detected. In statistics, a factorial design experiment is an experiment whose design consists of two or more factors, each with discrete possible values or levels, and whose experimental units take on all possible combinations of these levels across all such factors. Such an experiment allows studying the effect of each factor on the response variable, as well as the effects of interactions between factors on the response variable." ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "http://www.stats.gla.ac.uk/steps/glossary/anova.html#facdes And from wikipedia (01/03/2007): http://en.wikipedia.org/wiki/Factorial_experiment)" ; a owl:Class ; rdfs:label "factorial design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0500015 obo:IAO_0000111 "2x2 factorial design" ; obo:IAO_0000112 "PMID: 17561240-The present experiment evaluates the effects of intermittent exposure to a social stimulus on ethanol and water drinking in rats. Four groups of rats were arranged in a 2x2 factorial design with 2 levels of Social procedure (Intermittent Social vs Continuous Social) and 2 levels of sipper Liquid (Ethanol vs Water). Intermittent Social groups received 35 trials per session. Each trial consisted of the insertion of the sipper tube for 10 s followed by lifting of the guillotine door for 15 s. The guillotine door separated the experimental rat from the conspecific rat in the wire mesh cage during the 60 s inter-trial interval. The Continuous Social groups received similar procedures except that the guillotine door was raised during the entire duration of the session. For the Ethanol groups, the concentrations of ethanol in the sipper [3, 4, 6, 8, 10, 12, 14, and 16% (vol/vol)] increased across sessions, while the Water groups received 0% ethanol (water) in the sipper throughout the experiment. Both Social procedures induced more intake of ethanol than water. The Intermittent Social procedure induced more ethanol intake at the two highest ethanol concentration blocks (10-12% and 14-16%) than the Continuous Social procedure, but this effect was not observed with water. Effects of social stimulation on ethanol drinking are discussed." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a factorial design which has 2 experimental factors (aka independent variables) and 2 factor levels per experimental factors" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "PMID: 17561240" ; a owl:Class ; rdfs:label "2x2 factorial design" ; rdfs:subClassOf obo:OBI_0500014 . obo:OBI_0500016 obo:IAO_0000111 "fractional factorial design" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A fractional factorial design is_a study design in which only an adequately chosen fraction of the treatment combinations required for the complete factorial experiment is selected to be run" ; obo:IAO_0000117 "Philippe Rocca-Serra" ; obo:IAO_0000119 "http://www.itl.nist.gov/div898/handbook/pri/section3/pri334.htm From ASQC (1983) Glossary & Tables for Statistical Quality Control" ; a owl:Class ; rdfs:label "fractional factorial design" ; rdfs:subClassOf obo:OBI_0500014 . obo:OBI_0500017 obo:IAO_0000111 "dye swap design" ; obo:IAO_0000112 "PMID: 17411393-Dye-specific bias effects, commonly observed in the two-color microarray platform, are normally corrected using the dye swap design. This design, however, is relatively expensive and labor-intensive. We propose a self-self hybridization design as an alternative to the dye swap design. In this design, the treated and control samples are labeled with Cy5 and Cy3 (or Cy3 and Cy5), respectively, without dye swap, along with a set of self-self hybridizations on the control sample. We compare this design with the dye swap design through investigation of mouse primary hepatocytes treated with three peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists at three dose levels. Using Agilent's Whole Mouse Genome microarray, differentially expressed genes (DEG) were determined for both the self-self hybridization and dye swap designs. The DEG concordance between the two designs was over 80% across each dose treatment and chemical. Furthermore, 90% of DEG-associated biological pathways were in common between the designs, indicating that biological interpretations would be consistent. The reduced labor and expense for the self-self hybridization design make it an efficient substitute for the dye swap design. For example, in larger toxicogenomic studies, only about half the chips are required for the self-self hybridization design compared to that needed in the dye swap design." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An experiment design type where the label orientations are reversed. exact synonym: flip dye, dye flip" ; obo:IAO_0000117 "Philippe Rocca-Serra on behalf of MO" ; obo:IAO_0000119 "MO_858" ; a owl:Class ; rdfs:label "dye swap design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0500018 obo:IAO_0000111 "replicate design" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A replicate experimental design type is where a series of replicates are performed to evaluate reproducibility or as a pilot study to determine the appropriate number of replicates for a subsequent experiments." ; obo:IAO_0000117 "Philippe Rocca-Serra on behalf of MO" ; obo:IAO_0000119 "MO_885" ; a owl:Class ; rdfs:label "replicate design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0500019 obo:IAO_0000111 "self vs self design" ; obo:IAO_0000112 "PMID: 17411393-Dye-specific bias effects, commonly observed in the two-color microarray platform, are normally corrected using the dye swap design. This design, however, is relatively expensive and labor-intensive. We propose a self-self hybridization design as an alternative to the dye swap design. In this design, the treated and control samples are labeled with Cy5 and Cy3 (or Cy3 and Cy5), respectively, without dye swap, along with a set of self-self hybridizations on the control sample. We compare this design with the dye swap design through investigation of mouse primary hepatocytes treated with three peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists at three dose levels. Using Agilent's Whole Mouse Genome microarray, differentially expressed genes (DEG) were determined for both the self-self hybridization and dye swap designs. The DEG concordance between the two designs was over 80% across each dose treatment and chemical. Furthermore, 90% of DEG-associated biological pathways were in common between the designs, indicating that biological interpretations would be consistent. The reduced labor and expense for the self-self hybridization design make it an efficient substitute for the dye swap design. For example, in larger toxicogenomic studies, only about half the chips are required for the self-self hybridization design compared to that needed in the dye swap design." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A study design that investigates variance and error estimates in the experimental system, and is where the same extract is compared." ; obo:IAO_0000117 "Philippe Rocca-Serra on behalf of MO" ; obo:IAO_0000119 "MO_490" ; a owl:Class ; rdfs:label "self vs self design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0500020 obo:IAO_0000111 "time series design" ; obo:IAO_0000112 "PMID: 14744830-Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, agricultural and pharmaceutical sciences. There are myriad sources of uncertainty in microarray experiments, and rigorous experimental design is essential for fully realizing the potential of these valuable resources. Two questions frequently asked by biologists on the brink of conducting cDNA or two-colour, spotted microarray experiments are 'Which mRNA samples should be competitively hybridized together on the same slide?' and 'How many times should each slide be replicated?' Early experience has shown that whilst the field of classical experimental design has much to offer this emerging multi-disciplinary area, new approaches which accommodate features specific to the microarray context are needed. In this paper, we propose optimal designs for factorial and time course experiments, which are special designs arising quite frequently in microarray experimentation. Our criterion for optimality is statistical efficiency based on a new notion of admissible designs; our approach enables efficient designs to be selected subject to the information available on the effects of most interest to biologists, the number of arrays available for the experiment, and other resource or practical constraints, including limitations on the amount of mRNA probe. We show that our designs are superior to both the popular reference designs, which are highly inefficient, and to designs incorporating all possible direct pairwise comparisons. Moreover, our proposed designs represent a substantial practical improvement over classical experimental designs which work in terms of standard interactions and main effects. The latter do not provide a basis for meaningful inference on the effects of most interest to biologists, nor make the most efficient use of valuable and limited resources." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Groups of assays that are related as part of a time series." ; obo:IAO_0000117 "Philippe Rocca-Serra on behalf of MO" ; obo:IAO_0000119 "MO_887" ; a owl:Class ; rdfs:label "time series design" ; rdfs:subClassOf obo:OBI_0500000 . obo:OBI_0500022 obo:IAO_0000111 "stopping rule"@en ; obo:IAO_0000112 "PMID: 17591081-BACKGROUND/AIMS: To investigate the viral kinetics of Chinese CHC patients received pegylated interferon plus ribavirin and examine the impact of HCV genotypes and severity of liver disease. METHODOLOGY: 65 treatment-naove CHC patients who finished a 24-week therapy with peginterferon (alpha-2b (1.5 mcg/kg/week) plus ribavirin (1000-1200 mg /day) and 24 weeks of follow-up were enrolled. Hepatic fibrosis was graded by the METAVIR scoring system. Serum quantitative HCV RNA was determined by Versant HCV RNA 3.0 assay (Bayer Inc.). RESULTS: Genotype non-1 patients responded quickly and a higher percentage of them achieved undetectable HCV RNA (< 615 IU/mL) at week 4 compared with genotype 1 patients (93% vs. 69%, p = 0.018). Degree of hepatic fibrosis significantly affected end-of-treatment and sustained response (SVR). For patients who did not achieve early virological response (EVR), the negative predictive value for SVR was 100%. In genotype 1 patients, undetectable HCV RNA by week 4 was a good marker to predict treatment response, with a positive predictive value of 84% and a negative predictive value of 82%. CONCLUSIONS: EVR can be applied to Chinese patients as an early stopping rule. A 24-week duration of pegylated IFN/ribavirin might be adequate for genotype 1 patients who rapidly responded to therapy."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a stopping rule (criterion) is_a *rule* which causes a *stopping process* to happen"@en ; obo:IAO_0000117 "PRS"@en ; obo:IAO_0000119 "PRS"@en ; a owl:Class ; rdfs:label "stopping rule"@en ; rdfs:subClassOf obo:IAO_0000055 . obo:OBI_0500023 obo:IAO_0000111 "compliance rule"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a compliance rule is a rule which ensures a compliance process occurs"@en ; obo:IAO_0000117 "PRS"@en ; obo:IAO_0000119 "PRS"@en ; a owl:Class ; rdfs:label "compliance rule"@en ; rdfs:subClassOf obo:IAO_0000055 . obo:OBI_0500024 obo:IAO_0000111 "standard compliance rule"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a standard compliance rule is a compliance rule which defines conformity to a representation standard"@en ; obo:IAO_0000117 "PRS"@en ; obo:IAO_0000119 "PRS"@en ; a owl:Class ; rdfs:label "standard compliance rule"@en ; rdfs:subClassOf obo:OBI_0500023 . obo:OBI_0500025 obo:IAO_0000111 "ethical standard compliance rule"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "an ethical standard compliance rule is_a *compliance rule* which enable a *ethical compliance process* to occur"@en ; obo:IAO_0000117 "PRS"@en ; obo:IAO_0000119 "PRS"@en ; a owl:Class ; rdfs:label "ethical standard compliance rule"@en ; rdfs:subClassOf obo:OBI_0500024 . obo:OBI_0500026 obo:IAO_0000111 "eligibility criterion"@en ; obo:IAO_0000112 "PMID: 17579629 -Eligibility criteria included: untreated ED-SCLC; age >/=70 and performance status 0-2, or age <70 and PS 3."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 """an eligibility criterion (rule) is_a selection criterion which defines and states the requirements (positive or negative) for an entity to be considered as suitable for a given task or participation in a process."""@en ; obo:IAO_0000117 "Person: Philippe Rocca-Serra"@en ; obo:IAO_0000118 "eligibility rule"@en ; obo:IAO_0000119 "Adapted from Clinical Research Glossary Version 4.0 CDICS glossary group"@en ; a owl:Class ; rdfs:label "eligibility criterion"@en ; rdfs:subClassOf obo:OBI_0001755 . obo:OBI_0500027 obo:IAO_0000111 "inclusion criterion"@en ; obo:IAO_0000112 "PMID: 23979341-The major inclusion criterion was patients in whom severe cerebral embolism was diagnosed at age 75 or younger (more than 9 in the NIHSS score on day 7 after the onset of stroke) ."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "an inclusion criterion (rule) is_a *eligibility criterion* which defines and states a condition which, if met, makes an entity suitable for a given task or participation in a given process. For instance, in a study protocol, inclusion criteria indicate the conditions that prospective subjects MUST meet to be eligible for participation in a study."@en ; obo:IAO_0000117 "Person: Philippe Rocca-Serra"@en ; obo:IAO_0000118 "inclusion condition"@en, "inclusion rule"@en ; obo:IAO_0000119 "Adapted from Clinical Research Glossary Version 4.0 CDICS glossary group"@en ; a owl:Class ; rdfs:label "inclusion criterion"@en ; rdfs:subClassOf obo:OBI_0500026 . obo:OBI_0500028 obo:IAO_0000111 "exclusion rule"@en ; obo:IAO_0000112 "PMID: 17600285-Exclusion criteria included the use of any topical ophthalmic or topical oral medication and/or history of ocular or oral surgery within the past six months."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "an exclusion criterion (rule) is_a *eligibility criterion* which defines and states a condition which, if met, makes an entity unsuitable for a given task or participation in a given process. For instance, in a study protocol, exclusion criteria indicate the conditions that prospective subjects SHOULD NOT meet to be eligible for participation in a study"@en ; obo:IAO_0000117 "Person: Philippe Rocca-Serra"@en ; obo:IAO_0000119 "Adapted from Clinical Research Glossary Version 4.0 CDICS glossary group"@en ; a owl:Class ; rdfs:label "exclusion criterion"@en ; rdfs:subClassOf obo:OBI_0500026 . obo:OBI_0600000 obo:IAO_0000111 "adding substance to cell culture"@en ; obo:IAO_0000112 "adding fetal calf serum to a 96 well plate containing a cell culture derived from a blood sample of a patient"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "is process in which a material substance is added to a cell culture"@en ; obo:IAO_0000116 "renamed from 'administering substance to cell culture', to reflect that administration is commonly used only for organisms" ; obo:IAO_0000117 "Bjoern Peters"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "adding substance to cell culture"@en ; rdfs:subClassOf obo:OBI_0000274, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100060 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0100060 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000434 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_0000319 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0100060 ] ) ] ] ) ] . obo:OBI_0600002 obo:IAO_0000111 "tumor grading" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An assay that determines the grade (severity/stage) of a tumor sample, used in cancer biology to describe abnormalities/qualities of tumor cells or tissues. Values can be described by terms from NCI Thesaurus." ; obo:IAO_0000117 "Compiled by Helen Parkinson for Transcriptomics thanks to Adam Witney" ; obo:IAO_0000118 "grading of tumor" ; obo:IAO_0000119 "OBI branch derived; submitted by MO" ; a owl:Class ; rdfs:label "tumor grading" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100051 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OGMS_0000063 ] ] . obo:OBI_0600003 obo:IAO_0000111 "obsolete performing a clinical assessment" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A protocol application during which a series of tests are made of a patient leading to determination of disease state, or condition." ; obo:IAO_0000117 "PlanAndPlannedProcess Branch" ; obo:IAO_0000118 "clinical diagnosis" ; obo:IAO_0000119 "OBI branch derived" ; obo:IAO_0000231 obo:IAO_0000103 ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/623" ; a owl:Class ; rdfs:label "obsolete performing a clinical assessment" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0600004 obo:IAO_0000111 "human subject enrollment"@en ; obo:IAO_0000112 "enlisting familiy members of HIV patients into a study"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A planned process with the objective to obtain a population of human subjects to participate in an investigation by determining eligibility of subjects and obtaining informed consent."@en ; obo:IAO_0000116 "As with group assignment, should the specified output here be an organism which bears a role" ; obo:IAO_0000117 "Bjoern Peters"@en ; obo:IAO_0000119 "IEDB"@en ; obo:IAO_0000232 "criteria come from plan / clinical trial branch"@en ; a owl:Class ; rdfs:label "human subject enrollment"@en ; rdfs:subClassOf obo:OBI_0001928, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000810 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000059 ; owl:someValuesFrom obo:OBI_0500026 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000181 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0000181 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:NCBITaxon_9606 ] ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000097 ] ) ] ] . obo:OBI_0600005 obo:IAO_0000111 "collecting specimen from organism"@en ; obo:IAO_0000112 "taking a sputum sample from a cancer patient, taking the spleen from a killed mouse, collecting a urine sample from a patient"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "a process with the objective to obtain a material entity that was part of an organism for potential future use in an investigation"@en ; obo:IAO_0000117 "PERSON:Bjoern Peters"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "collecting specimen from organism"@en ; rdfs:subClassOf obo:OBI_0000659, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100026 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0100051 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000684 ] . obo:OBI_0600006 obo:IAO_0000111 "killing"@en ; obo:IAO_0000112 "Terminal sacrifice of animals by cervical dislocation at the end of an investigation."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A protocol application in which an organism is intentionally put to death"@en ; obo:IAO_0000116 "difficult to place this properly - JG. Death process (e.g. unscheduled death) is out of scope but should be added somewhere. All killings have death process as a part, but not all death processes are part of a killing."@en ; obo:IAO_0000117 "Jennifer Fostel"@en, "Philippe Rocca-Serra" ; obo:IAO_0000118 "death status type"@en, "euthanisia"@en, "life termination"@en, "sacrifice"@en ; obo:IAO_0000119 "CEBS, Biomaterial_branch"@en ; a owl:Class ; rdfs:label "killing"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001421 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001422 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0600007 obo:IAO_0000111 "administering substance in vivo"@en ; obo:IAO_0000112 "Balb/c mice received an intracameral or subconjunctival injection of trinitrophenylated spleen cells", "injecting mice with 10 ug morphine intranasally, a patient taking two pills of 1 mg aspirin orally"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A process by which a substance is intentionally given to an organism resulting in exposure of the organism to that substance." ; obo:IAO_0000116 "2009-11-10. Tracker: https://sourceforge.net/tracker/?func=detail&aid=2893050&group_id=177891&atid=886178", "Different routes and means of administration should go as children underneath this"@en, """Update the definition based on the discussion. Details see the tracker: https://sourceforge.net/p/obi/obi-terms/738/""", "needs roles such as perturber and perturbee (children of input role). Perturb is too strong. Host might be the name for one role. Others considered: Doner, Donated, Acceptor."@en ; obo:IAO_0000117 "Bjoern Peters"@en, "Person:Bjoern Peters" ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "administering substance in vivo"@en ; rdfs:subClassOf obo:OBI_0000274, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100026 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0100026 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000434 ], [ a owl:Restriction ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ; owl:onProperty obo:OBI_0000299 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_0000319 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000444 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0100026 obo:UBERON_0000465 ) ] ] ) ] ] ) ] . obo:OBI_0600008 obo:IAO_0000111 "acquisition"@en ; obo:IAO_0000112 "Downloading a 3D structure from the PDB. Purchasing antibodies from sigma." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A planned process with the objective of gaining possession of an entity."@en ; obo:IAO_0000116 "5/31/2012 - OBI workshop: This process is not implying ownership of the material / information.", """Following OBI call November 2012,5th: addition of a restriction to acquisition class to capture the need of having selection criteria Relates to the creation of a class 'selection rule'"""@en ; obo:IAO_0000117 "Bjoern Peters"@en ; obo:IAO_0000119 "IEDB"@en ; obo:IAO_0000232 "This needs to be fleshed out and logical definitions added that will allow to place the children terms automatically under acquisition"@en ; a owl:Class ; rdfs:label "acquisition"@en ; rdfs:subClassOf obo:OBI_0001928, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000059 ; owl:someValuesFrom obo:OBI_0001755 ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:BFO_0000040 obo:IAO_0000030 ) ] ] . obo:OBI_0600009 obo:IAO_0000111 "exposure of material to environment"@en ; obo:IAO_0000112 "Putting cells in a freezer at -80C. Cy5-labeled DNA is irradiated with a laser to excite the fluorophore. Inducing a phase transition in a material by putting it in an environment with a specific temperature. Oxygen deprivation in a chamber."@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a planned process in which an input material is exposed to a defined set of conditions in a controlled environment. The environment is a specified input."@en ; obo:IAO_0000117 "Bjoern Peters"@en ; obo:IAO_0000119 "IEDB"@en ; obo:IAO_0000232 "Alan says there will be problmes, e.g. with selection by survival"@en ; a owl:Class ; rdfs:label "exposure of material to environment"@en ; rdfs:subClassOf obo:OBI_0000011 . obo:OBI_0600010 obo:IAO_0000111 "material acquisition"@en ; obo:IAO_0000112 "Acquiring 50 C57BL/6 mice bred in the animal facility of the institute as a service to investigators. Purchasing 1 mg of peptides synthesized by Mimotopes at 80% purity. Getting a gift of purified CD4+ specific antibodies presented by Stephen Schoenberger at LIAI."@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An acquisition in which possession of a material entity is gained."@en ; obo:IAO_0000116 "The assumption is that the object already exists in its current state, e.g, an available mouse strain purchased from the Jackson Lab, this is the differentia from specimen creation", "This excludes processes that create or change materials, such as material transformations." ; obo:IAO_0000117 "Bjoern Peters, Alan Ruttenberg, Helen Parkinson"@en ; obo:IAO_0000118 "material procurement" ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "material acquisition"@en ; rdfs:subClassOf obo:OBI_0600008, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:BFO_0000040 ] . obo:OBI_0600011 obo:IAO_0000111 "acclimatization"@en ; obo:IAO_0000112 "placing mice in animal facility for 2 weeks prior to an experiment to accustom them to their environment, reducing stress"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A protocol application in which an object is left in an environment for some period of time, until some qualities of interest are in equilibrium with that environment."@en ; obo:IAO_0000117 "Jennifer Fostel"@en ; obo:IAO_0000119 "CEBS, Biomaterial_branch"@en ; a owl:Class ; rdfs:label "acclimatization"@en ; rdfs:subClassOf obo:OBI_0600009 . obo:OBI_0600012 obo:IAO_0000111 "environmental material collection"@en ; obo:IAO_0000112 "Taking 1 liter of surface ocean water from the San Diego Mission Bay Jetty. Capturing mice living in rural Arkansas"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "environmental_material_collection is an acquisition where an object is taken from an environment and put into a storage container. Roles include, environment, thing collected, container, acquirer."@en ; obo:IAO_0000116 """relabel the term and add axiom connecting to EnVO:'environmental material' discussed on obi-dev call 9/28/2015, details see: https://sourceforge.net/p/obi/obi-terms/779/""" ; obo:IAO_0000117 "Bjoern Peters, Alan Ruttenberg"@en ; obo:IAO_0000119 "IEDB"@en ; obo:IAO_0000232 "the researcher is very interested in the location"@en ; a owl:Class ; rdfs:label "environmental material collection process"@en ; rdfs:subClassOf obo:OBI_0000659, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:ENVO_00010483 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0100051 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000684 ] . obo:OBI_0600013 obo:IAO_0000111 "information acquisition"@en ; obo:IAO_0000112 "Gathering all influenza HA sequences from GenBank, Retrieveing HLA allele frequencies in the North American populations from dbMHC"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An acquisition in which possession of information is gained."@en ; obo:IAO_0000116 "This excludes processes that create or change information, such as assays and data transformations." ; obo:IAO_0000117 "Bjoern Peters"@en ; obo:IAO_0000118 "data collection" ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "information acquisition"@en ; rdfs:subClassOf obo:OBI_0600008, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000030 ] . obo:OBI_0600014 obo:IAO_0000111 "material component separation"@en ; obo:IAO_0000112 "Using a cell sorter to separate a mixture of T cells into two fractions; one with surface receptor CD8 and the other lacking the receptor, or purification"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "a material processing in which components of an input material become segregated in space"@en ; obo:IAO_0000117 "Bjoern Peters"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "material component separation"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:BFO_0000040 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:BFO_0000040 ] ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000639 ] . obo:OBI_0600015 obo:IAO_0000111 "group assignment"@en ; obo:IAO_0000112 "Assigning' to be treated with active ingredient role' to an organism during group assignment. The group is those organisms that have the same role in the context of an investigation"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "group assignment is a process which has an organism as specified input and during which a role is assigned"@en ; obo:IAO_0000117 "Philippe Rocca-Serra"@en ; obo:IAO_0000118 "cohort assignment", "study assignment" ; obo:IAO_0000119 "OBI Plan"@en ; a owl:Class ; rdfs:label "group assignment"@en ; rdfs:subClassOf obo:OBI_0000011, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100026 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000023 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0100026 ] ) ] ] . obo:OBI_0600016 obo:IAO_0000111 "pooling specimens" ; obo:IAO_0000112 "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=104564; Combining spleens of 20 mice, Combining supernatant from a cell culture obtained at different time points"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "physical combination of several instances of like material"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000118 "sample pooling"@en ; obo:IAO_0000119 "OBI branch derived"@en ; obo:IAO_0000232 "like' is one of the things that you should be controling for in a well-designed experiment. The instances of material need to have the same class."@en ; a owl:Class ; rdfs:label "pooling specimens"@en ; rdfs:subClassOf obo:OBI_0000652, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100051 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0302716 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000686 ], [ a owl:Restriction ; owl:minCardinality "2"^^xsd:nonNegativeInteger ; owl:onProperty obo:OBI_0000293 ] . obo:OBI_0600017 obo:IAO_0000111 "assay detecting a molecular label" ; obo:IAO_0000112 "Determination of the amount of phycoerytherin label present in a cell population stained with anti-CD8-PE in order to determine the percentage of CD8+ T cells present" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An assay that detects the presence or a quality of a molecular label which is a proxy for the detection of the molecular target to which the label is attached" ; obo:IAO_0000117 "Matthew Brush" ; obo:IAO_0000119 "OBI developer call, 3-12-12" ; a owl:Class ; rdfs:label "assay detecting a molecular label" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0001936 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001936 ] ] . obo:OBI_0600018 obo:IAO_0000111 "material portioning"@en ; obo:IAO_0000112 "pouring 50 mL aliquots of fetal calf serum into conical tubes from a 500 mL stock"@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "a material processing in which the input substance is partitioned into a number of portions that are similar in composition."@en ; obo:IAO_0000117 "PERSON:Bjoern Peters"@en ; obo:IAO_0000118 "aliquoting"@en, "apportioning"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "material portioning"@en ; rdfs:subClassOf obo:OBI_0600014, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000678 ] . obo:OBI_0600019 obo:IAO_0000111 "non-specific labeling"@en ; obo:IAO_0000112 "The addition of phycoerytherin label to an anti-CD8 antibody, to label all antibodies."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "The addition of a reagent labeling the entire input biomaterial enabling future detection of the output biomaterial"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; obo:IAO_0000232 "definition blessed by Allyson, Bjoern, Jay & Randi"@en ; a owl:Class ; rdfs:label "non-specific labeling"@en ; rdfs:subClassOf obo:OBI_0600038 . obo:OBI_0600020 obo:IAO_0000111 "histological assay" ; obo:IAO_0000112 "the counting of the number of cells with fluorescent label at their surface to determine the percentage of the population which was activated" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An assay that uses visual examination of cells or tissue (or images of them) to make an assessment regarding a quality of the cells or tissue. This assay can include steps of staining, imaging, and judgement." ; obo:IAO_0000117 "Adam Witney", "Helen Parkinson" ; obo:IAO_0000118 "histology", "histopathology" ; obo:IAO_0000119 "OBI branch derived" ; a owl:Class ; rdfs:label "histological assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000341 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000185 obo:OBI_0003368 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:CL_0000000 obo:OBI_0100066 ) ] ] ] . obo:OBI_0600021 obo:IAO_0000111 "cell fixation"@en ; obo:IAO_0000112 "http://www.tissuearray.org/CellLinesProtocolforTMA112.pdf; the treatment of CD8+ cells with methanol at -20oC; http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=16080188&dopt=AbstractPlus"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a protocol application to preserve defined qualities of cells or tissues (sample) which may otherwise change over time"@en ; obo:IAO_0000116 "should include capturing what qualities are being preserved"@en ; obo:IAO_0000117 "PERSON:Bjoern Peters"@en ; obo:IAO_0000119 "OBI branch derived"@en ; obo:IAO_0000232 "we could generalize this for other input materials"@en ; a owl:Class ; rdfs:label "cell fixation"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:OBI_0100051 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:CHEBI_23367 obo:OBI_0302729 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0600022 obo:IAO_0000111 "excision"@en ; obo:IAO_0000112 "Cutting out the portion of a gel which contains a DNA fragment"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "the use physical means to remove a portion of a substance from the rest"@en ; obo:IAO_0000117 "Alan Ruttenberg, Kevin Clancy"@en ; obo:IAO_0000119 "www.crohnsresource.com/glossary.jsp (via google define:resection)"@en ; a owl:Class ; rdfs:label "excision"@en ; rdfs:subClassOf obo:OBI_0600014, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000681 ] . obo:OBI_0600023 obo:IAO_0000111 "non specific enzymatic cleavage"@en ; obo:IAO_0000112 "The use of agarase to digest an agar gel"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "an enzymatic cleavage that uses an enzyme without a strong affinity for specific cleavage sites in the input material"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "non specific enzymatic cleavage"@en ; rdfs:subClassOf obo:OBI_0000231 ; owl:disjointWith obo:OBI_0600050 . obo:OBI_0600024 obo:IAO_0000111 "maintaining cell culture"@en ; obo:IAO_0000112 "When harvesting blood from a human, isolating T cells, and then limited dilution cloning of the cells, the maintaining_cell_culture step comprises all steps after the initial dilution and plating of the cells into culture, e.g. placing the culture into an incubator, changing or adding media, and splitting a cell culture"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A planned process with the objective to keep cells alive in a defined environment outside of an organism."@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "maintaining cell culture"@en ; rdfs:subClassOf obo:OBI_0000838, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100060 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0000079 obo:OBI_0001912 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0100060 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000806 ] . obo:OBI_0600025 obo:IAO_0000111 "substance detection assay" ; obo:IAO_0000112 "the detection of phycoerytherin by means of flow cytometry" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An assay that detects a specified substance" ; obo:IAO_0000117 "Kevin Clancy" ; obo:IAO_0000119 "OBI branch derived" ; a owl:Class ; rdfs:label "substance detection assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:BFO_0000040 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000109 ] . obo:OBI_0600026 obo:IAO_0000111 "longitudinal mass measurement assay" ; obo:IAO_0000112 "The comparison of the weight of vaccinated and non-vaccinated mice after infection with influenza A over 6 weeks post-infection" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures the mass of a material at two or more time points" ; obo:IAO_0000117 "Helen Parkinson" ; obo:IAO_0000119 "OBI branch derived" ; a owl:Class ; rdfs:label "longitudinal mass measurement assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:BFO_0000040 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:IAO_0000414 ] . obo:OBI_0600027 obo:IAO_0000111 "artificially induced cell membrane lysis"@en ; obo:IAO_0000112 "http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=16080188&dopt=AbstractPlus; The destruction of cell membranes with detergent."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a material transformation to break the membranes of cells, releasing the cells contents; input=>cells; output=>cell_lysate"@en ; obo:IAO_0000116 "---\\nThere is a more general 'membrane lysis', which could apply to artificial membranes etc. For this general membrane encapsulated objects would need to be defined."@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "artificially induced cell membrane lysis"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0600028 obo:IAO_0000111 "artificially induced reverse transcription"@en ; obo:IAO_0000112 "The use of M-MLV reverse transcriptase from the Moloney murine leukemia virus to transcribe an RNA sample into cDNA"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a protocol with the objective to transcribe single-stranded RNA into complementary DNA (cDNA)"@en ; obo:IAO_0000116 "It could also be added that the reverse transcriptase is bearer of a GO:0003964 RNA-directed DNA polymerase activity, which is realized in this process.", "We need to indicate the relationship between the cDNA generated and the RNA that was used as a template. This may be outside of the OBI scope"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "artificially induced reverse transcription"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33697 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000419 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:CHEBI_16991 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0600029 obo:IAO_0000111 "isolation of cell culture supernatant"@en ; obo:IAO_0000112 "Pouring out a portion of the fluid part of an adherant cell culture growing in a flask.; The centrifugation of a T cell culture followed by aspiration of the supernatant while the cellular pellet remains in the centrifuge tube."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a protocol which results in the separation of supernatant material from a cell culture"@en ; obo:IAO_0000116 "This does not apply to the case where the cells are lysed"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "isolation of cell culture supernatant"@en ; rdfs:subClassOf obo:OBI_0600014, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000681 ] . obo:OBI_0600030 obo:IAO_0000111 "experimental disease induction"@en ; obo:IAO_0000112 "the injection of mice with LCM virus iv to establish an LCMV infection. Witholding food from animals to induce starvation syndrome."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a protocol application to induce a specific disease in an organism"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; obo:IAO_0000232 "could be defined class"@en ; a owl:Class ; rdfs:label "experimental disease induction"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0600031 obo:IAO_0000111 "enzyme-linked immunospot assay" ; obo:IAO_0000112 "Determination of the frequency of cells producing IFN-gamma in response to viral peptides by placing effector cells on a anti IFN-gamma coated plate, and adding antigen presenting cells pulsed with a peptide. After washing, the bound IFN-gamma is detected with a secondary antibody linked to a dye that visualizes as one spot per cell." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay in which cells are cultured on a surface coated with a capture antibody binding a secretory material of interest which subsequently gets stained resulting in a spot for each cell producing the secretory material of interest." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000118 "ELISPOT assay" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "enzyme-linked immunospot assay" ; rdfs:subClassOf obo:OBI_0001977, obo:OBI_0003587, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0100060 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100060 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042571 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:GO_0042571 ] ) ] . obo:OBI_0600032 obo:IAO_0000111 "artificially induced DNA repair"@en ; obo:IAO_0000112 "the use of DNA repair enzymes uracil DNA glycosylase and 3-methyladenine DNA glycosylase to repair DNA strands"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a protocol application to repair damaged DNA molecules"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; obo:IAO_0000232 "---\\nis this really a protocol?\\n--> This as several other protocol applications is also a natural process. The fact that it is induced experimetnally by following a protocol makes it a protocol application. Need to make sure that labels don't conflict wi"@en ; a owl:Class ; rdfs:label "artificially induced DNA repair"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0600033 obo:IAO_0000111 "cell permeabilization"@en ; obo:IAO_0000112 "Electroporation of HeLa cells to allow transfection with pUC19."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A protocol application to permeabilize cell membranes, allowing molecules to more easily pass through the membrane than was possible prior to the protocol application"@en ; obo:IAO_0000116 "need to add output cell has_quality permeable"@en ; obo:IAO_0000117 "PERSON:Bjoern Peters"@en ; obo:IAO_0000119 "OBI branch derived"@en ; obo:IAO_0000232 "definition blessed by Jay, Alan, Randi"@en ; a owl:Class ; rdfs:label "cell permeabilization"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CL_0000000 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:CL_0000000 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0600034 obo:IAO_0000111 "precipitation"@en ; obo:IAO_0000112 "The use of ethanol to precipitate DNA molecules from a solution containing DNA"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a protocol application to cause a material to precipitate (becoming a solid) out of solution. Input is a solution, output is a solution plus a solid component (the precipitate)"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "precipitation"@en ; rdfs:subClassOf obo:OBI_0600014, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000681 ] . obo:OBI_0600036 obo:IAO_0000111 "'establishing cell culture'" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a process through which a new type of cell culture or cell line is created, either through the isolation and culture of one or more cells from a fresh source, or the deliberate experimental modification of an existing cell culture (e.g passaging a primary culture to become a secondary culture or line, or the immortalization or stable genetic modification of an existing culture or line)." ; obo:IAO_0000117 "PERSON:Matthew Brush" ; obo:IAO_0000119 "PERSON:Matthew Brush" ; a owl:Class ; rdfs:comment "A 'cell culture' as used here referes to a new lineage of cells in culture deriving from a single biological source.. New cultures are established through the initial isolation and culturing of cells from an organismal source, or through changes in an existing cell culture or line that result in a new culture with unique characteristics. This can occur through the passaging/selection of a primary culture into a secondary culture or line, or experimental modifications of an existing cell culture or line such as an immortalization process or other stable genetic modification. This class covers establishment of cultures of either multicellular organism cells or unicellular organisms." ; rdfs:label "establishing cell culture" ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CL_0000000 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000079 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0100060 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0600037 obo:IAO_0000111 "cell culture splitting"@en ; obo:IAO_0000112 "The act of taking a cell culture of high density, counting the cells, removing part of the cells, and re-seeding a select number of the cells into new flasks with fresh tissue culture media."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "The act of taking part of a homogeneous cell culture and creating one or more additional separate cultures of similar qualities. input: cell_culture, output cell_culture min cardinality 2. part of cell culturing"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000118 "cell culture passaging" ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:comment "An active cell culture is typically split when it has grown to confluence in its culture dish. Cell culture splitting of a cell culture sample results in an increase in its passage number, which measures how long a sample has been propagated in vitro, and therefore how many selective or genetic changes it is likely to have undergone." ; rdfs:label "cell culture splitting"@en ; rdfs:subClassOf obo:OBI_0600014, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100060 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0100060 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000678 ] . obo:OBI_0600038 obo:IAO_0000111 "addition of molecular label"@en ; obo:IAO_0000112 "The addition of phycoerytherin label to an anti-CD8 antibody, to label all antibodies. The addition of anti-CD8-PE to a population of cells, to label the subpopulation cells that are CD8+."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a material processing technique intended to add a molecular label to some input material entity, to allow detection of the molecular target of this label in a detection of molecular label assay"@en ; obo:IAO_0000117 "PERSON:Matthew Brush"@en ; obo:IAO_0000118 "labeling" ; obo:IAO_0000119 "OBI developer call, 3-12-12"@en ; a owl:Class ; rdfs:label "addition of molecular label"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0002744 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_1110109 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001936 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0600039 obo:IAO_0000111 "artificially induced methylation"@en ; obo:IAO_0000112 "the use of enzymes to add methyl groups to DNA molecules"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A planned process of adding methyl groups to polymers"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "artificially induced methylation"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0600040 obo:IAO_0000111 "synthesis" ; obo:IAO_0000112 "making cDNA from nucleotides using RNA as a template"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "the construction of a biomaterial from simpler biomaterials"@en ; obo:IAO_0000116 "This probably needs breaking down into more specific applications. The example given is already covered in reverse_transcription"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000118 "synthesize"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "synthesis"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_23367 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:CHEBI_23367 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0600041 obo:IAO_0000111 "concentrate"@en ; obo:IAO_0000112 "Evaporation of the solution containing DNA to increase the concentration of the DNA molecules"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a protocol application to create an output material with an increased density of a material of interest that is part of the input material by separating other parts of the input material"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "concentrate"@en ; rdfs:subClassOf obo:OBI_0600014, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000681 ] . obo:OBI_0600042 obo:IAO_0000111 "recombinant plasmid cloning"@en ; obo:IAO_0000112 "The DNA fragment encoding the p35 gene from Mycobacterium avium complex was inserted into pcDNAII and expressed in E coli in order to study p35."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "the insertion of a particular DNA fragment into a plasmid in order to make copies of a biomaterial"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "recombinant plasmid cloning"@en ; rdfs:subClassOf obo:OBI_0600064 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600064 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000430 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000411 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000410 ] ) ] . obo:OBI_0600043 obo:IAO_0000111 "genetic transformation"@en ; obo:IAO_0000112 "The transduction of E. coli through the introduction of a plasmid encoding for M. avium p35"@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "the introduction. alteration or integration of genetic material into a cell or organism"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000118 "genetic modification"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "genetic transformation"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001151 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0001153 ] . obo:OBI_0600044 obo:IAO_0000111 "lavage"@en ; obo:IAO_0000112 "the collection of bronchoalveolar lavage fluid (BAL) from the lungs of mice in order to study the cytokines present"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A protocol application to separate cells and/or cellular secretions from an anatomical space by the introduction and removal of fluid"@en ; obo:IAO_0000116 "This is not washing, in which case the material of interest is not the resulting fluid"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "lavage"@en ; rdfs:subClassOf obo:OBI_0600005, obo:OBI_0600014, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000639 ] . obo:OBI_0600045 obo:IAO_0000111 "3D structure determination assay" ; obo:IAO_0000112 "The use of X-ray crystallography to determine the 3D coordinates of atoms in a protein." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that determines the 3-dimensional configuration of an input material." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "3D structure determination assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001155 ] ) ] . obo:OBI_0600046 obo:IAO_0000111 "preparative chromatography"@en ; obo:IAO_0000112 "The use of gas chromatography in order separate out from an input sample of eggs a fraction that would be enriched for pesticides."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "the use of a biomaterial's preferential affinity for either the mobile phase or the stationary phase to separate it from other materials of differing affinity"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy; Bjoern Peters"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "preparative chromatography"@en ; rdfs:subClassOf obo:OBI_0600014, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000318 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000681 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom obo:OBI_0000038 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom obo:OBI_0000048 ] . obo:OBI_0600047 obo:IAO_0000111 "sequencing assay" ; obo:IAO_0000112 "The use of the Sanger method of DNA sequencing to determine the order of the nucleotides in a DNA template" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "An assay the uses chemical or biochemical means to infer the sequence of a biomaterial" ; obo:IAO_0000117 "PlanAndPlannedProcess Branch" ; obo:IAO_0000119 "OBI branch derived" ; a owl:Class ; rdfs:label "sequencing assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0001108 obo:OBI_0001137 obo:OBI_0400103 ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0001108 obo:OBI_0001137 obo:OBI_0400103 ) ] ] ) ] [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0001010 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:unionOf (obo:OBI_0001010 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000000001 ] ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000973 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:SO_0000001 ] ] ) ] . obo:OBI_0600048 obo:IAO_0000111 "vector mediated amplification" ; obo:IAO_0000112 "E coli expressing the gene for M avium p35 were cultured in order to produce p35."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "The process of creating a copy of some biological entity in cell culture"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "vector mediated amplification"@en ; rdfs:subClassOf obo:OBI_0600064 . obo:OBI_0600049 obo:IAO_0000111 "DNA polymerase amplification"@en ; obo:IAO_0000112 "The use of taq polymerase to amplify a DNA fragment during a PCR."@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "DNA polymerase amplification is an enzymatic amplification which uses DNA polymerase enzyme to make copies of a DNA contained in biomaterial used as input"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en, "Philippe Rocca-Serra" ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "DNA polymerase amplification"@en ; rdfs:subClassOf obo:OBI_0600058, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:GO_0042575 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33697 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:BFO_0000040 ] ) ] ] . obo:OBI_0600050 obo:IAO_0000111 "specific enzymatic cleavage"@en ; obo:IAO_0000112 "The use of a protease to digest a protein into peptides"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "an enzymatic cleavage that uses an enzyme with a strong affinity for specific cleavage sites in the input material"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "specific enzymatic cleavage"@en ; rdfs:subClassOf obo:OBI_0000231 . obo:OBI_0600051 obo:IAO_0000111 "gradient separation"@en ; obo:IAO_0000112 "the use of a sucrose gradient to isolate mitochondria"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a protocol application that uses different concentrations of materials in a defined order to create a gradient to facilitate the separation of an input material into its components with specific qualities"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "gradient separation"@en ; rdfs:subClassOf obo:OBI_0600014, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000681 ] . obo:OBI_0600052 obo:IAO_0000111 "dialysis"@en ; obo:IAO_0000112 "the use of a dialysis bag of select pore size to remove salt from collagen isolated from mouse cartilage"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a protocol application that uses diffusion through a semi-permeable membrane to separate an input material into two fractions of different composition"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "dialysis"@en ; rdfs:subClassOf obo:OBI_0600014, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000681 ] . obo:OBI_0600053 obo:IAO_0000111 "electrophoresis"@en ; obo:IAO_0000112 "Loading a mixture of proteins into a polyacrylamide gel and the application of an electrical current to the gel to separate the proteins by size and change."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a protocol application that uses an electrical potential to move material through a defined matrix in order to separate it by its resistance to movement and its charge"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000119 "OBI branch derived"@en ; obo:IAO_0000232 "Need to define more terms like gel_separation, matrix,centrifugation, and the connection between the force used to separate materials and the medium or barriers."@en ; a owl:Class ; rdfs:label "electrophoresis"@en ; rdfs:subClassOf obo:OBI_0600014, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0000432 obo:OBI_0000439 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000681 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom obo:OBI_0400140 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom obo:OBI_0400142 ] . obo:OBI_0600054 obo:IAO_0000111 "selection by survival"@en ; obo:IAO_0000112 "The insertion of a gene for antibiotic resistance into a cell population and subsequent growth in the presence of the antibiotic to select for those cells which were successfully transfected"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "the use of environmental conditions to select for the organism or cells that have a certain trait"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "selection by survival"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0600055 obo:IAO_0000111 "DNA cleavage, restriction analysis"@en ; obo:IAO_0000112 "the use of the restriction enzymes SalPI and PstI to cleave DNA into fragments, assay made up of components"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specific enzymatic cleavage of DNA molecules using endonucleases that cleave DNA molecules at specific sites based on the surrounding nucleotide sequence"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000118 "restriction enzyme assay"@en ; a owl:Class ; rdfs:label "DNA restriction enzyme digestion"@en ; rdfs:subClassOf obo:OBI_0600050, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33697 ] . obo:OBI_0600056 obo:IAO_0000111 "protease cleavage"@en ; obo:IAO_0000112 "the use of trypsin to cleave pepsin into peptide fragments"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "protease cleavage is an enzymatic cleavage which relies on enzyme with protease activity to act on proteins and produce polypeptides (protein fragments)."@en ; obo:IAO_0000116 "enzymatic digestion"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "protease cleavage"@en ; rdfs:subClassOf obo:OBI_0000231, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000000001 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:BFO_0000040 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:CHEBI_16670 ] . obo:OBI_0600057 obo:IAO_0000111 "enzymatic DNA replication"@en ; obo:IAO_0000112 "the use of enzymes to duplicate DNA molecules"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "the use of enzymes to duplicate DNA molecule any process used to make additional copies of a biomaterial"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "enzymatic DNA replication"@en ; rdfs:subClassOf obo:OBI_0600058 . obo:OBI_0600058 obo:IAO_0000111 "enzymatic amplification"@en ; obo:IAO_0000112 "the use of a polymerase chain reaction to amplify a fragment of DNA"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "the use of enzymes to increase the number of molecules of a biomaterial"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "enzymatic amplification"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000427 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000409 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0600059 obo:IAO_0000111 "DNA transduction"@en ; obo:IAO_0000112 "The transfer of a recombinant bacterial plasmid into E.coli to facilitate amplification of a specific protein"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a genetic transformation which relies on the use of lysogenic infection to transfer DNA sequences into an organism"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "DNA transduction"@en ; rdfs:subClassOf obo:OBI_0600043, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:NCBITaxon_10239 ] . obo:OBI_0600060 obo:IAO_0000111 "DNA transfection"@en ; obo:IAO_0000112 "The use of electroporation to permeabilize a cell membrane in order to introduce a plasmid encoding for a labeled protein of interest"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a transfection which relies on the use of physical, electrical and chemical phenomena to introduce DNA into a cell"@en ; obo:IAO_0000117 "PERSON:Kevin Clancy"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "DNA transfection"@en ; rdfs:subClassOf obo:OBI_0001152, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16991 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:OBI_0000444 ] ) ] ] . obo:OBI_0600063 obo:IAO_0000111 "vector mediated expression"@en ; obo:IAO_0000112 "Construction of pRSS1327 expression vector by molecular cloning of a 1327-bp cDNA, which includes sequences of the entire coding region for RSS, into pBluescript. Expression in Escherichia coli of a functional, full-length RSS was confirmed by immunoblot analysis and enzymatic activity." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "vector mediated expression sis the generation of copies of biomaterial by in a cell_culture modified for this purpose by insertion of an expression vector"@en ; obo:IAO_0000116 "needs defined relationship to cell culture"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "vector mediated expression"@en ; rdfs:subClassOf obo:OBI_0600064 . obo:OBI_0600064 obo:IAO_0000111 "recombinant vector cloning"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a planned process with the objective to insert genetic material into a cloning vector for future replication of the inserted material"@en ; obo:IAO_0000117 "pa_branch (Alan, Randi, Kevin, Jay, Bjoern)"@en ; obo:IAO_0000118 "molecular cloning" ; obo:IAO_0000119 "OBI branch derived"@en ; a owl:Class ; rdfs:label "recombinant vector cloning"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_0000411 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000737 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000416 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000731 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_0600065 obo:IAO_0000111 "obsolete_defined processes" ; obo:IAO_0000114 obo:IAO_0000121 ; obo:IAO_0000115 "Place holder class, see editor note" ; obo:IAO_0000117 "PlanAndPlannedProcess Branch" ; obo:IAO_0000119 "OBI branch derived" ; obo:IAO_0000231 obo:IAO_0000226 ; a owl:Class ; rdfs:label "obsolete_defined processes" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_0600067 obo:IAO_0000111 "specific labeling"@en ; obo:IAO_0000112 "The addition of anti-CD8 antibody for an ICCS assay in order to selectively stain the CD8+ cells"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a labeling in which the labeling reagent used has a specificity to bind only certain components of the input material"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; obo:IAO_0000232 "definition blessed by Allyson, Bjoern, Jay & Randi"@en ; a owl:Class ; rdfs:label "specific labeling"@en ; rdfs:subClassOf obo:OBI_0600038 . obo:OBI_0666666 obo:IAO_0000111 "RNA extraction"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A RNA extraction is a nucleic acid extraction where the desired output material is RNA"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; obo:IAO_0000232 "requested by Helen Parkinson for MO"@en ; a owl:Class ; rdfs:label "RNA extraction"@en ; rdfs:subClassOf obo:OBI_0666667, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000880 ] . obo:OBI_0666667 obo:IAO_0000111 "nucleic acid extraction"@en ; obo:IAO_0000112 "Phenol / chlorophorm extraction disolvation of protein content folllowed by ethanol precipitation of the nucleic acid fraction over night in the fridge followed by centrifugation to obtain a nucleic acid pellet."@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a material separation to recover the nucleic acid fraction of an input material"@en ; obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ; obo:IAO_0000119 "OBI branch derived"@en ; obo:IAO_0000232 "requested by Helen Parkinson for MO. Could be defined class"@en ; a owl:Class ; rdfs:label "nucleic acid extraction"@en ; rdfs:subClassOf obo:OBI_0302884, [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0000671 obo:OBI_0100026 obo:OBI_0100060 ) ] ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001010 ] . obo:OBI_1000023 obo:IAO_0000111 "cell culture supernatant"@en ; obo:IAO_0000112 """solution containing RPMI, fetal calf sera, antibiotics, and monoclonal antibody UCHT1. Isolation of proliferation factor of immature T-cell clone in concanavalin A-stimulated splenocyte culture supernatant. Immunology. 2003 Jun;109(2):209-16. PMID: 12757615"""@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "Supernatant of a cell culture is a material entity which contains media, supplements, and secreted products of the cells and becomes the environment of cultivated cell."@en ; obo:IAO_0000117 "PERSON: Bjoern Peters"@en ; obo:IAO_0000119 "GROUP: IEDB"@en ; a owl:Class ; rdfs:label "cell culture supernatant"@en ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600029 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:OBI_0000079 ] . obo:OBI_1000024 obo:IAO_0000111 "cell pellet"@en ; obo:IAO_0000112 "Detection of fetal DNA in a cell pellet after centrifugation of mountant. J Forensic Sci. 2003 Jan;48(1):135-6. PMID: 12570214"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A material entity which results from the aggregation of cells produced by the application of centrifugal force to a liquid containing cells in suspension"@en ; obo:IAO_0000117 "PERSON: Helen Parkinson"@en, "PERSON: Philippe Rocca-Serra" ; obo:IAO_0000119 "GROUP: CEBS"@en, "GROUP: OBI Biomaterial Branch" ; a owl:Class ; rdfs:label "cell pellet"@en ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0302886 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:OBI_0100060 obo:OBI_0100067 ) ] ] . obo:OBI_1000029 obo:IAO_0000111 "phage display library"@en ; obo:IAO_0000112 "PMID: 15905471.Nucleic Acids Res. 2005 May 19;33(9):e81.Oligonucleotide-assisted cleavage and ligation: a novel directional DNA cloning technology to capture cDNAs. Application in the construction of a human immune antibody phage-display library. [Phage display library encoding fragments of human antibodies. m-rna library encoding for 9-mer peptides]"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a phage display library is a collection of materials in which a mixture of genes or gene fragments is expressed and can be individually selected and amplified."@en ; obo:IAO_0000117 "PERSON: Bjoern Peters"@en, "PERSON: Philippe Rocca-Serra"@en ; obo:IAO_0000118 "display library"@en ; obo:IAO_0000119 "WEB: http://www.immuneepitope.org/home.do"@en ; obo:IAO_0000232 """PRS: 22022008. class moved under population, modification of definition and replacement of biomaterials in previous definition with 'material' addition of has_role restriction"""@en ; a owl:Class ; rdfs:label "phage display library"@en ; rdfs:subClassOf obo:OBI_0000731, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600064 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom obo:OBI_0000731 ] . obo:OBI_1000036 obo:IAO_0000111 "cell lysate"@en ; obo:IAO_0000112 "The effect of vaccination with the lysate of heat-shocked tumor cells on nitric oxide production in BALB/c mice with fibrosarcoma tumor. Cell Biol Int. 2008 Jul;32(7):835-40. PMID: 18455932" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a cell lysate is a material entity which is output of a cell lysis process"@en ; obo:IAO_0000116 """PRS:22-02-2008: is a material which has output_role during lysis protocol-application. old defintion: A mixture (collection) of cell components created by rupturing of the cell wall resulting from a lysis process"""@en ; obo:IAO_0000117 "PERSON: Susanna Sansone"@en ; obo:IAO_0000118 "lysate"@en, "lysed material" ; obo:IAO_0000119 "GROUP: PSI"@en ; a owl:Class ; rdfs:label "cell lysate"@en ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0302894 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:CL_0000000 ] . obo:OBI_1000042 obo:IAO_0000111 "peptide construct"@en ; obo:IAO_0000112 """Multiple Antigenic Peptide (MAP) construct containing T and B cell epitopes from p. falciparum congugated to a central glycin A novel multivalent human CTL peptide construct elicits robust cellular immune responses in HLA-A*0201 transgenic mice: implications for HTLV-1 vaccine design. Vaccine. 2003 Jun 20;21(21-22):2767-81. PMID: 12798617"""@en ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "a material entity synthesized to contain a number of peptides conjugated together in a non-linear fashion"@en ; obo:IAO_0000117 "PERSON: Bjoern Peters"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "peptide construct"@en ; rdfs:subClassOf obo:OBI_0000047, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_16670 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0302892 ] . obo:OBI_1000048 obo:IAO_0000111 "transgenic organism"@en ; obo:IAO_0000112 """HLA-A*0201 transgenic mice, Vaccinia virus expressing the LCMV gp protein Possible ecological risks of transgenic organism release when transgenes affect mating success: sexual selection and the Trojan gene hypothesis. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13853-6. PMID: 10570162"""@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a transgenic organism is material entity which derives from an organism which has been modified to express a gene not normally part of it"@en ; obo:IAO_0000116 "PRS:22-02-2008: is a organism which has output_role during genetic modification of type (KO) protocol-application"@en ; obo:IAO_0000117 "PERSON: Bjoern Peters"@en, "PERSON: Philippe Rocca-Serra" ; obo:IAO_0000119 "GROUP:IEDB"@en ; a owl:Class ; rdfs:label "transgenic organism"@en ; rdfs:subClassOf obo:OBI_0302859, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600043 ] . obo:OBI_1000049 obo:IAO_0000111 "whole mount tissue"@en ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A whole organism preparation resulting from a histological preparation known as whole mount preparation where the whole specimen is mounted or spread on the microscope (glass) slide"@en ; obo:IAO_0000117 "PERSON: Helen Parkinson"@en, "PERSON: Philippe Rocca-Serra" ; obo:IAO_0000118 "whole mount sample"@en ; obo:IAO_0000119 "GROUP: OBI"@en ; obo:IAO_0000232 "PRS:22-02-2008: indicates the need to create a protocol application and distinguish it from this entity"@en, "PRS:22-02-2008: is a material which has output_role during whole mount preparation protocol-application"@en ; a owl:Class ; rdfs:label "whole mount tissue"@en ; rdfs:subClassOf obo:OBI_0000680, obo:OBI_0000953, obo:OBI_0001479, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000341 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0000465 ] . obo:OBI_1000207 obo:IAO_0000111 "assay bead"@en ; obo:IAO_0000112 "Dynabeads are commercially available magnetic beads which are precoated with antibodies specific for select cellular receptors and are used to separate cell populations."@en ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A globular or round particle of defined physicochemical properties and size which can be exploited as either the primary substance for detection or as a secondary solid platform for the attachment of bioactive molecules."@en ; obo:IAO_0000116 "DS: Probably better modeled as a role."@en ; obo:IAO_0000117 "OBI"@en ; obo:IAO_0000118 "bead"@en ; a owl:Class ; rdfs:label "assay bead"@en ; rdfs:subClassOf obo:OBI_0000047 . obo:OBI_1110001 obo:IAO_0000111 "epitope" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A material entity with the disposition to be bound by an adaptive immune receptor."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "epitope"@en ; rdfs:subClassOf obo:BFO_0000040 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:OBI_1110045 ] . obo:OBI_1110002 obo:IAO_0000111 "obsolete_occurrence of disease" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An occurrence of disease is a process involving pathologic changes within an organism" ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:IAO_0000231 obo:IAO_0000228 ; a owl:Class ; rdfs:label "obsolete_occurrence of disease" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_1110003 obo:IAO_0000111 "host exposure to infectious agent" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a process in which an infectious agent comes into physical contact with a host organism."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "host exposure to infectious agent"@en ; rdfs:subClassOf obo:GO_0008150 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000925 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:OBI_1110026 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_1110026 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:OBI_0000925 ] ) ] ] ) ] . obo:OBI_1110007 obo:IAO_0000111 "administration in vivo with infectious agent" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "is an administration of an infectious agent to a host organism" ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "administration in vivo with infectious agent" ; rdfs:subClassOf obo:OBI_0600007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000319 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000925 ] ) ] ] . obo:OBI_1110008 obo:IAO_0000111 "occurrence of infectious disease" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Is an occurrence of a disease caused by an infection"@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "occurrence of infectious disease"@en ; rdfs:subClassOf obo:OGMS_0000063, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_1110021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_1110093 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:RO_0002087 ; owl:someValuesFrom obo:OBI_1110003 ] ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_1110040 ] . obo:OBI_1110010 obo:IAO_0000111 "disposition to cause an allergic reaction" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The role borne by a material entity that is realized when it is recognized by the immune system and results in the occurrence of an allergic disease."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000118 "allergenic disposition" ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "disposition to cause an allergic reaction"@en ; rdfs:subClassOf obo:BFO_0000016, [ a owl:Restriction ; owl:allValuesFrom obo:OBI_1110011 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_1110011 obo:IAO_0000111 "allergic reaction" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "an allergic reaction is an pathologic immune response by an organism to a non-self entity that is normally harmless(the allergen)"@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "allergic reaction"@en ; rdfs:subClassOf obo:OBI_1110122, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_1110010 ] . obo:OBI_1110012 obo:IAO_0000111 "occurrence of allergy" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The process of an allergic disease occurring in an organism."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "occurrence of allergy"@en ; rdfs:subClassOf obo:OGMS_0000063, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_1110011 ] ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_1110049 ] . obo:OBI_1110013 obo:IAO_0000111 "ELISPOT assay measuring epitope specific interleukin-2 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunospot assay that detects interleukin-2 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-2 release|ELISPOT" ; a owl:Class ; rdfs:label "ELISPOT assay measuring epitope specific interleukin-2 production by T cells" ; rdfs:subClassOf obo:OBI_0001445, obo:OBI_0600031 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600031 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032623 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110014 obo:IAO_0000111 "epitope binding by adaptive immune receptor" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is the process in which an adaptive immune receptor binds to a material entity (realizing its disposition). The binding affinity is significant enough to trigger an immune response. Specifically, transient non-specific binding of adaptive immune receptors occurring during immune surveillance is not considered significant binding."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "epitope binding by adaptive immune receptor"@en ; rdfs:subClassOf obo:GO_0008150 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_1110045 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:OBI_1110119 ; owl:someValuesFrom obo:OBI_1110022 ] ) ] ] ) ] ] . obo:OBI_1110015 obo:IAO_0000111 "Immunization in vivo" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Process of administering an object playing the role of immunogen to a living organism"@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "Immunization in vivo"@en ; rdfs:subClassOf obo:OBI_1110094, [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom obo:OBI_0100026 ] . obo:OBI_1110016 obo:IAO_0000111 "adaptive immune effector function" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A function realized as an immune response, which inheres in a T cell, B cell or antibody which derives from or is produced by a cell with prior antigen experience."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "adaptive immune effector function"@en ; rdfs:subClassOf obo:BFO_0000034, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:CL_0000084 obo:CL_0000236 obo:GO_0042571 ) ] ], [ a owl:Restriction ; owl:allValuesFrom obo:GO_0002250 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_1110017 obo:IAO_0000111 "living with infected household contact" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a process in which a a human being lives in the same household as another human being that is known to be infected with an infectious agent" ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "living with infected household contact"@en ; rdfs:subClassOf obo:OBI_1110111 . obo:OBI_1110018 obo:IAO_0000111 "living in endemic area" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a process in which a potential host organism lives in a geographic area in which an infectious agent is present to such a degree of frequency that contact is likely" ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "living in endemic area"@en ; rdfs:subClassOf obo:OBI_1110111 . obo:OBI_1110019 obo:IAO_0000111 "pathogen release in laboratory accident" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a process in which a an infectious agent maintained in a laboratory setting is not contained as planned, leading to potential exposure of human beings to the agent" ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "pathogen release in laboratory accident"@en ; rdfs:subClassOf obo:OBI_1110111 . obo:OBI_1110020 obo:IAO_0000111 "Immunization in vitro" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A planned process with the objective to administer an object playing the role of immunogen to a cell culture."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "Immunization in vitro"@en ; rdfs:subClassOf obo:OBI_0000094, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_1110094 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0100060 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0100060 ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000417 ; owl:someValuesFrom obo:OBI_0000456 ] . obo:OBI_1110021 obo:IAO_0000111 "infection process" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "the detrimental process in which an infectious agent colonizes or replicates in a host environment"@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "infection process"@en ; rdfs:subClassOf obo:OBI_1110122, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_1110093 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom obo:IDO_0000586 ] . obo:OBI_1110022 obo:IAO_0000111 "adaptive immune receptor" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is a receptor produced by cells of the adaptive immune system with the purpose of binding epitopes."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "adaptive immune receptor"@en ; rdfs:subClassOf obo:GO_0032991 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:GO_0019815 obo:GO_0042101 obo:GO_0042571 ) ] . obo:OBI_1110023 obo:IAO_0000111 "immunogen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a material entity bearing the immunogen role"@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "immunogen"@en ; rdfs:subClassOf obo:BFO_0000040 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_1110082 ] . obo:OBI_1110024 obo:IAO_0000111 "environmental exposure to infectious agent" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Is a process in which an infectious agent is in direct contact with a potential host organism in its habitat. This is preceded by proximity to the infectious agent"@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "environmental exposure to infectious agent"@en ; rdfs:subClassOf obo:GO_0008150 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0008150 [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Class ; owl:unionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_0000925 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:OBI_0000925 ] ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_1110083 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002087 ; owl:someValuesFrom obo:OBI_1110111 ] ) ] . obo:OBI_1110026 obo:IAO_0000111 "host of immune response" ; obo:IAO_0000112 "A mouse that is vaccinated with a peptide and develops protective immunity. A human exposed to bacteria that are killed by pre-existing immune responses." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An organism in which an immune response process occurs."@en ; obo:IAO_0000116 "In immune response processes in the context of infectious diseases and allergy, there are often multiple organisms involved, which requires calling out the 'host'. This terminology is expanded to allergy, cancer and transplantation." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "host of immune response"@en ; rdfs:subClassOf obo:OBI_0100026 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0100026 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_1110083 ] ) ] . obo:OBI_1110028 obo:IAO_0000111 "293-T cell line" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cell line derived from human embryonic kidney cells. This cell line contains the SV40 Large T-antigen, allowing episomal replication of transfected plasmids containing the SV40 origin of replication." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en, "http://www.biotech.ist.unige.it/cldb/cl5008.html"@en ; a owl:Class ; rdfs:label "293-T cell line"@en ; rdfs:subClassOf obo:CLO_0009828 . obo:OBI_1110029 obo:IAO_0000111 "C1R cell line" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cell line derived from human B cells. This cell line was created by EBV transformation (B-lymphoblastoid cell-line (BLCL))." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "C1R cell line"@en ; rdfs:subClassOf obo:CLO_0009828 . obo:OBI_1110030 obo:IAO_0000111 "experimental infection of cell culture" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is the administration of an infectious agent to a cell culture with the objective to have the agent colonize and replicate in culture"@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "experimental infection of cell culture"@en ; rdfs:subClassOf obo:OBI_0600000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000319 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000925 ] ) ] ] . obo:OBI_1110031 obo:IAO_0000111 "EL-4 cell line" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cell line derived from mouse (C57BL/6N) lymphoma cells." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en, "http://www.biotech.ist.unige.it/cldb/cl1160.html"@en ; a owl:Class ; rdfs:label "EL-4 cell line"@en ; rdfs:subClassOf obo:CLO_0009828 . obo:OBI_1110032 obo:IAO_0000111 "HeLa cell culture" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cell line derived from human cervical cancer cells." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en, "http://www.biotech.ist.unige.it/cldb/cl1597.html"@en ; a owl:Class ; rdfs:label "HeLa cell line"@en ; rdfs:subClassOf obo:CLO_0009828 . obo:OBI_1110033 obo:IAO_0000111 "JAWS II cell line" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cell line derived from mouse dendritic cells." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en, "http://www.atcc.org/ATCCAdvancedCatalogSearch/ProductDetails/tabid/452/Default.aspx?ATCCNum=CRL-11904&Template=cellBiology"@en ; a owl:Class ; rdfs:label "JAWS II cell line"@en ; rdfs:subClassOf obo:CLO_0009828 . obo:OBI_1110034 obo:IAO_0000111 "antigen" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A material entity that has the antigen role."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "antigen"@en ; rdfs:subClassOf obo:BFO_0000040 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000237 ] . obo:OBI_1110035 obo:IAO_0000111 "Jurkat cell line" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cell line derived from human T cells." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en, "http://www.biotech.ist.unige.it/cldb/cl5296.html"@en ; a owl:Class ; rdfs:label "Jurkat cell line"@en ; rdfs:subClassOf obo:CLO_0009828 . obo:OBI_1110036 obo:IAO_0000111 "JY cell line" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The JY cell line is an Epstein-Barr virus (EBV)-immortalised b cell lymphoblastoid line.(wikipedia)" ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "JY cell line"@en ; rdfs:subClassOf obo:CLO_0009828 . obo:OBI_1110037 obo:IAO_0000111 "assay measuring binding of a T cell epitope:MHC:TCR complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope assay that measures the binding of T cell receptor to an epitope." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "T cell binding|any method" ; a owl:Class ; rdfs:label "assay measuring binding of a T cell epitope:MHC:TCR complex" ; rdfs:subClassOf obo:OBI_0003128 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001181 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_1110057 ] ] ) ] . obo:OBI_1110038 obo:IAO_0000111 "RMA cell line" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cell line derived from a mouse lymphoma, specifically a Rauscher virus-induced tumor.This cell ine is antigen processing-defective and expresses a very low level of MHC molecules on its surface." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "RMA cell line"@en ; rdfs:subClassOf obo:CLO_0009828 . obo:OBI_1110039 obo:IAO_0000111 "T2 cell line" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A human T-B lymphoblastoid hybrid cell line" ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en, "http://www.atcc.org/ATCCAdvancedCatalogSearch/ProductDetails/tabid/452/Default.aspx?ATCCNum=CRL-1992&Template=cellBiology"@en ; a owl:Class ; rdfs:label "T2 cell line"@en ; rdfs:subClassOf obo:CLO_0009828 . obo:OBI_1110040 obo:IAO_0000111 "infectious disease" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is a disease caused by an infectious agent"@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "infectious disease"@en ; rdfs:subClassOf obo:OGMS_0000031 . obo:OBI_1110041 obo:IAO_0000111 "lymph node cell specimen" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cell specimen comprised of a mixed population of cells obtained by processing whole lymph node into individual cells, typically performed using a sieve. This population includes T cells, B cells, macrophages, and other cell types." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "lymph node cell specimen"@en ; rdfs:subClassOf obo:OBI_0000953, obo:OBI_0001468, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_1110046 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0000029 ] ) ] ] . obo:OBI_1110043 obo:IAO_0000111 "cultured adherent cell population" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A mixed cell population that is characterized by its ability to bind to tissue culture flasks or plates. This population typically contains macrophages and other cells capable of playing the antigen presenting cell role." ; obo:IAO_0000116 """MHB 3-27-13: Following CLO alignment efforts, propose to update definition to read: \"A cultured cell population comprised of cells that are able to grow attached to a solid substrate provided by tissue culture flasks or plates\". The current definition seems to describe a more specific type of adherent culture of immunological origin as needed by IEDB. MHB 3-5-13: Need to review axiom on this class in light of clarification that it refers to a cell line sample, and not an entire line. Not every population of adhernet cells is the output of an isolation process.""" ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000118 "adherent cell culture sample" ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "cultured adherent cell population"@en ; rdfs:subClassOf obo:OBI_0100060 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0100060 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000540 ] ) ] . obo:OBI_1110044 obo:IAO_0000111 "cultured PBMC cell population" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A mixed cell population obtained by processing whole blood. The cells are characterized by having a similar density and are largely mononuclear cells (includes T cells, B cells, and other cell types)." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000118 "PBMC cell culture sample" ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "cultured PBMC cell population"@en ; rdfs:subClassOf obo:OBI_0001875 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001875 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000548 ] ) ] . obo:OBI_1110045 obo:IAO_0000111 "disposition to be bound by an adaptive immune receptor" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Is the disposition borne by a material entity that is realized in a process of being bound by a adaptive immune receptor."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000118 "epitope disposition" ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "disposition to be bound by an adaptive immune receptor"@en ; rdfs:subClassOf obo:BFO_0000016, [ a owl:Restriction ; owl:allValuesFrom obo:OBI_1110014 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_1110046 obo:IAO_0000111 "organ harvesting" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The process of removing an organ from its source organism"@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "organ harvesting"@en ; rdfs:subClassOf obo:OBI_0600014 . obo:OBI_1110047 obo:IAO_0000111 "cultured CD3+ T cell population" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A T cell population characterized by expressing the CD3 molecule on its surface." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000118 "CD3+ T cell culture sample" ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "cultured CD3+ T cell population"@en ; rdfs:subClassOf obo:OBI_0001875 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001875 [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001018 ] ) ] ] ) ] . obo:OBI_1110048 obo:IAO_0000111 "cultured CD3- T cell population" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A T cell population characterized by not expressing the CD3 molecule on its surface." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000118 "CD3- T cell culture sample" ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "cultured CD3- T cell population"@en ; rdfs:subClassOf obo:OBI_0001875 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001875 [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Class ; owl:complementOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001018 ] ] ) ] ] ) ] . obo:OBI_1110049 obo:IAO_0000111 "allergy" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is a disease in which an abnormally strong inflammatory immune response is triggered against non-self entities, and the immune response has no protective effect"@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "allergy"@en ; rdfs:subClassOf obo:OGMS_0000031 . obo:OBI_1110050 obo:IAO_0000111 "cultured CD4- T cell population" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A T cell population characterized by not expressing the CD4 molecule on its surface." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000118 "CD4- T cell culture sample" ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "cultured CD4- T cell population"@en ; rdfs:subClassOf obo:OBI_0001875 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001875 [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Class ; owl:complementOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001004 ] ] ) ] ] ) ] . obo:OBI_1110051 obo:IAO_0000111 "cultured CD8- T cell population" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A T cell population characterized by not expressing the CD8 molecule on its surface." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000118 "CD8- T cell culture sample" ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "cultured CD8- T cell population"@en ; rdfs:subClassOf obo:OBI_0001875 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001875 [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Class ; owl:complementOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000025402 ] ] ) ] ] ) ] . obo:OBI_1110052 obo:IAO_0000111 "cultured CD4-/CD8- T cell population" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A T cell population characterized by not expressing the CD4 nor the CD8 molecule on its surface." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000118 "CD4-/CD8- T cell culture sample" ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "cultured CD4-/CD8- T cell population"@en ; rdfs:subClassOf obo:OBI_1110050, obo:OBI_1110051 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001875 [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Class ; owl:complementOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001004 ] ] [ a owl:Class ; owl:complementOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000025402 ] ] ) ] ] ) ] . obo:OBI_1110053 obo:IAO_0000111 "cancer" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A disease characterized by abnormal and uncontrolled cell division"@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "cancer"@en ; rdfs:subClassOf obo:OGMS_0000031 . obo:OBI_1110054 obo:IAO_0000111 "autoimmune disease" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Is a disease characterized by an immune response of an organism against parts of itself"@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "autoimmune disease"@en ; rdfs:subClassOf obo:OGMS_0000031 . obo:OBI_1110055 obo:IAO_0000111 "obsolete_disease" ; obo:IAO_0000114 obo:IAO_0000121 ; obo:IAO_0000115 "placeholder to be imported from disease ontology" ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:IAO_0000231 obo:IAO_0000228 ; obo:IAO_0100001 obo:OGMS_0000031 ; a owl:Class ; rdfs:label "obsolete_disease" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_1110056 obo:IAO_0000111 "epitope specific IL-2 release by T cells" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A biological process where T cells produce IL-2 resulting from the recognition of a T cell epitope."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "epitope specific IL-2 release by T cells"@en ; rdfs:subClassOf obo:GO_0032623, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032623 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_1110057 obo:IAO_0000111 "MHC:epitope complex binding to TCR" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a process of an MHC molecule binding to an entity playing the role of epitope to create an MHC:epitope complex which is then bound by a TCR molecule."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "MHC:epitope complex binding to TCR"@en ; rdfs:subClassOf obo:OBI_0001588, obo:OBI_1110014, [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_1110045 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:OBI_1110119 ; owl:someValuesFrom obo:GO_0042101 ] [ a owl:Restriction ; owl:onProperty obo:OBI_1110119 ; owl:someValuesFrom obo:GO_0042611 ] ) ] ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_1110086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042611 ] ) ] ] . obo:OBI_1110059 obo:IAO_0000111 "ELISPOT assay measuring epitope specific interferon-gamma production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunospot assay that detects interferon-gamma production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IFNg release|ELISPOT" ; a owl:Class ; rdfs:label "ELISPOT assay measuring epitope specific interferon-gamma production by T cells" ; rdfs:subClassOf obo:OBI_0001414, obo:OBI_0600031 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600031 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032609 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110060 obo:IAO_0000111 "process is result of" ; obo:IAO_0000112 "The production of IFN-gamma by effector T cells is a process result of T cell stimulation through the TCR" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is a relationship between a process and a preceding occurrent that directly caused the later one to occur" ; obo:IAO_0000117 "IEDB", "PERSON:Bjoern Peters" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000003 ; rdfs:label "process is result of" ; rdfs:range obo:BFO_0000003 ; rdfs:subPropertyOf obo:RO_0002087 . obo:OBI_1110061 obo:IAO_0000111 "exposure resulting in immune reactivity" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a process in which an organism (host) is exposed to some material entity, which results in an immune reactivity" ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "exposure resulting in immune reactivity"@en ; rdfs:subClassOf obo:GO_0008150 . obo:OBI_1110082 obo:IAO_0000111 "immunogen role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A role of a material entity that is realized when the material elicits an immune response targeting itself in whole or in part."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "immunogen role"@en ; rdfs:subClassOf obo:BFO_0000023 . obo:OBI_1110083 obo:IAO_0000111 "host of immune response role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "is a role borne by an organism. It is realized by the organism during an immunization or an immune response taking place inside or on the surface of the organism, and in which the responding or stimulated immune system is part of the host."@en ; obo:IAO_0000116 "03/21/2010: This sense of 'host' is used not only in infectious diseases but also allergy, cancer, transplantation, etc. which is why it is needed separately from the 'host of infectious agent' meaning, which will be imported from IDO." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "host of immune response role"@en ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:allValuesFrom [ a owl:Class ; owl:unionOf (obo:GO_0006955 obo:OBI_1110015 ) ] ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_1110084 obo:IAO_0000111 "effector T cell function" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The function inhering in a T cell that is realized in an immune response that results from the T cell receptor binding to the MHC:epitope complex."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "effector T cell function"@en ; rdfs:subClassOf obo:OBI_1110016, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000084 ], [ a owl:Restriction ; owl:allValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0002250 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_1110085 obo:IAO_0000111 "antigen presentation function" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a function inhering in a cell that expresses MHC molecules which is realized in the process of antigen processing and presentation of antigen derived parts by MHC molecules on the cell surface."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000118 "APC"@en ; obo:IAO_0000119 "IEDB"@en ; obo:IAO_0000232 "should add a reference to the antigen processing and presentation process." ; a owl:Class ; rdfs:label "antigen presentation function"@en ; rdfs:subClassOf obo:BFO_0000034, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042611 ] ) ] ] . obo:OBI_1110086 obo:IAO_0000111 "restricting MHC role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The role played by an MHC molecule by binding a material entity playing the role of epitope when that epitope/MHC molecule pair are recognized (bound) by a TCR molecule on the surface of a cell playing the role of effector cell."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "restricting MHC role"@en ; rdfs:subClassOf obo:BFO_0000023 . obo:OBI_1110087 obo:IAO_0000111 "donor" ; obo:IAO_0000112 "A T cell line from a PPD(+) donor." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A role which inheres in an organism or part thereof from which any part including cell, organ or tissue is removed with the intention that the donated part will be placed into another organism and/or cultured in vitro."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000118 "donor role" ; obo:IAO_0000119 "IEDB"@en ; obo:IAO_0000232 "Definition modified by HP to deal with the case where an organ may be removed for donation but is not transplanted as intended." ; a owl:Class ; rdfs:label "donor role"@en ; rdfs:subClassOf obo:BFO_0000023 . obo:OBI_1110091 obo:IAO_0000111 "immune epitope carrier role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A role inhering in a material entity that is covalently bound to an epitope in order to increase the epitopes immunogenicity."@en ; obo:IAO_0000116 "03/21/2010, BP: surveying the literature, this seems to be a messy term. Need to clarify what material entities can be carriers, and if only immunogenicity (not antigenicity) is effected by their presence." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "immune epitope carrier role"@en ; rdfs:subClassOf obo:BFO_0000023 . obo:OBI_1110092 obo:IAO_0000111 "adjuvant role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Adjuvant role is a role that inheres in a material entity and which is realized through a process of modifying a biological response."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000118 "adjuvent role" ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "adjuvant role"@en ; rdfs:subClassOf obo:BFO_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:BFO_0000040 ], [ a owl:Restriction ; owl:allValuesFrom obo:GO_0008150 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_1110093 obo:IAO_0000111 "disposition to infect an organism" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Is a role borne by an agent, and realized when in contact with or inside another organism in which it is capable of replicating and causing disease"@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "disposition to infect an organism"@en ; rdfs:subClassOf obo:BFO_0000016, [ a owl:Restriction ; owl:allValuesFrom obo:OBI_1110021 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_1110094 obo:IAO_0000111 "immunization" ; obo:IAO_0000112 "Infection with influenza (the immunogen) leading to B cells producing antibodies (the effector function) against surface regions of the HA protein (the epitope)." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "The process of an epitope that is part of or derived from an immunogen coming into contact with adaptive immune cells resulting in these cells acquiring immune effector functions specific for the epitope."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "immunization"@en ; rdfs:subClassOf obo:GO_0008150 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0008150 [ a owl:Class ; owl:unionOf ([ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_1110001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:OBI_1110023 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_1110001 [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:OBI_1110023 ] ) ] ] ) ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:OBI_1110014 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OBI_1110082 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000057 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:unionOf (obo:CL_0000084 obo:CL_0000236 ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_1110016 ] ) ] ] ) ] . obo:OBI_1110095 obo:IAO_0000111 "blood harvesting" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A material separation where blood is taken from an organism."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "blood harvesting"@en ; rdfs:subClassOf obo:OBI_0600014, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0000655 ] . obo:OBI_1110099 obo:IAO_0000111 "L cell line" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cell line derived from mouse fibroblasts." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en, "http://www.biotech.ist.unige.it/cldb/cl3075.html"@en ; a owl:Class ; rdfs:label "L cell line"@en ; rdfs:subClassOf obo:CLO_0009828 . obo:OBI_1110106 obo:IAO_0000111 "cultured antigen presenting cell population" ; obo:IAO_0000112 "A culture of PBMCs. A culture of Hela cells." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a cell culture including cells that have an antigen presentation function" ; obo:IAO_0000118 "antigen presenting cell culture sample" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "cultured antigen presenting cell population" ; rdfs:subClassOf obo:OBI_0001875 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001875 [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_1110085 ] ) ] ] ) ] . obo:OBI_1110107 obo:IAO_0000111 "cultured effector T cell population" ; obo:IAO_0000112 "A culture of cytotoxic CD8+ T cells." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cell culture including cells that have an effector T cell function" ; obo:IAO_0000118 "culture of effector T cells", "effector T cell culture sample" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "cultured effector T cell population" ; rdfs:subClassOf obo:OBI_0001875 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0001875 [ a owl:Restriction ; owl:onProperty obo:OBI_0000643 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom obo:OBI_1110084 ] ) ] ] ) ] . obo:OBI_1110108 obo:IAO_0000111 "material to be added" ; obo:IAO_0000112 "A mixture of peptides that is being added into a cell culture." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A material entity that is added to another material entity in an “adding a material entity into a target” process." ; obo:IAO_0000116 "10/26/09: This defined class is used as a 'macro expression' to reduce the size of the IEDB export", "2010/02/24 Alan Ruttenberg: I think this might generate confusion as the common use of the term would consider something to be a specimen during the realization of the role, not only if it bears it. However having this class as a probe, or for display, or as a macro might be useful. Ideally we would mark or segregate such classes" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "material to be added" ; rdfs:subClassOf obo:BFO_0000040 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000319 ] . obo:OBI_1110109 obo:IAO_0000111 "target of material addition" ; obo:IAO_0000112 "A cell culture into which a mixture of peptides is being added." ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A material entity that receives the addition of another material entity in an “adding a material entity into a target” process." ; obo:IAO_0000116 "10/26/09: This defined class is used as a 'macro' to reduce the size of the IEDB export." ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "target of material addition" ; rdfs:subClassOf obo:BFO_0000040 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000444 ] . obo:OBI_1110111 obo:IAO_0000111 "environmental proximity to infectious agent" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "Is a process in which an infectious agent comes close enough to a potential host organism in its habitat that a contact can result"@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "environmental proximity to infectious agent"@en ; rdfs:subClassOf obo:GO_0008150 . obo:OBI_1110112 obo:IAO_0000111 "is_described_by" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000231 obo:IAO_0000103 ; a owl:ObjectProperty ; rdfs:label "obsolete_is_described_by" ; rdfs:subPropertyOf oboInOwl:ObsoleteProperty ; owl:deprecated true . obo:OBI_1110114 obo:IAO_0000111 "contact to pathogen carrying biological vector" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "a process in which a vector carrying an infectious agent comes close enough to a potential host organism that a contact can result" ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "contact to pathogen carrying biological vector"@en ; rdfs:subClassOf obo:OBI_1110111 . obo:OBI_1110116 obo:IAO_0000111 "splenocyte specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cell specimen comprised of a mixed cell population obtained by processing whole spleen into individual cells, typically performed using a sieve or blender. This population includes T cells, B cells, macrophages, and other cell types." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "splenocyte specimen"@en ; rdfs:subClassOf obo:OBI_0000953, obo:OBI_0001468, [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_1110046 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] ] . obo:OBI_1110118 obo:IAO_0000111 "P815 cell line" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A cell line derived from mouse mastocytoma." ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en, "http://www.biotech.ist.unige.it/cldb/cl5244.html"@en ; a owl:Class ; rdfs:label "P815 cell line"@en ; rdfs:subClassOf obo:CLO_0009828 . obo:OBI_1110119 obo:IAO_0000111 "bound_to" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A relationship between two material entities that form a complex based on a selective, non-covalent interaction." ; obo:IAO_0000116 "The definition of this term is modeled after the Chebi:50967 and GO:0005488 terms. Further alignment of the logical definitions with those ontologies will require agreement on the placement of GO:molecular function in BFO among other things. OBI will retire this term once such an alignment is achieved as 'bound to' is not in the primary OBI scope." ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "bound_to" ; rdfs:range obo:BFO_0000040 . obo:OBI_1110120 obo:IAO_0000111 "assay antigen role" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An antigen role that is realized as part of an assay, where immune recognition of the material with the assay antigen role is being detected as part of the assay."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "assay antigen role"@en ; rdfs:subClassOf obo:OBI_0000237, [ a owl:Restriction ; owl:allValuesFrom obo:OBI_0000070 ; owl:onProperty obo:BFO_0000054 ] . obo:OBI_1110122 obo:IAO_0000111 "pathologic process" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "abnormal, harmful processes caused by or associated with a disease"@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "pathologic process"@en ; rdfs:subClassOf obo:GO_0008150 . obo:OBI_1110124 obo:IAO_0000111 "assay measuring qualitative binding of a T cell epitope:MHC:TCR complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that detects the binding of a MHC:epitope complex with a T cell receptor, and produces a qualitative measurement of the binding as an output." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "qualitative binding|binding assay" ; a owl:Class ; rdfs:label "assay measuring qualitative binding of a T cell epitope:MHC:TCR complex" ; rdfs:subClassOf obo:OBI_1110037 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0003141 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_1110057 ] ] ) ] . obo:OBI_1110125 obo:IAO_0000111 "assay measuring MHC ligand processing and presentation" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A MHC ligand assay that determines what ligands are processed and loaded onto MHC molecules by eluting ligands and identifying them." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "ligand presentation|any method" ; a owl:Class ; rdfs:label "assay measuring MHC ligand processing and presentation" ; rdfs:subClassOf obo:OBI_0002075 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042611 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001503 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:GO_0019882 ] ) ] ] ] ) ] . obo:OBI_1110126 obo:IAO_0000111 "assay measuring binding of a MHC:ligand complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A MHC ligand assay that detects the binding of a ligand to an MHC molecule." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "MHC binding|any method" ; a owl:Class ; rdfs:label "assay measuring binding of a MHC:ligand complex" ; rdfs:subClassOf obo:OBI_0002075 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001181 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001503 ] ] ) ] . obo:OBI_1110127 obo:IAO_0000111 "assay measuring binding of a B cell epitope:antibody complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A B cell epitope assay that measures the binding of an antibody receptor to an epitope." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "antibody binding|any method" ; a owl:Class ; rdfs:label "assay measuring binding of a B cell epitope:antibody complex" ; rdfs:subClassOf obo:OBI_0003127 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001181 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_0001702 ] ] ) ] . obo:OBI_1110128 obo:IAO_0000111 "immune epitope assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that detects the binding of an epitope to an adaptive immune receptor, or an immune process resulting from such a binding event, or characterizes the structrue of the complex resulting from such a binding event." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "immune epitope assay" ; a owl:Class ; rdfs:label "immune epitope assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf ([ a owl:Class ; owl:unionOf (obo:OBI_0001503 obo:OBI_0003121 ) ] [ a owl:Class ; owl:unionOf (obo:OBI_0001702 obo:OBI_0003119 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_0001702 ] ) ] [ a owl:Class ; owl:unionOf (obo:OBI_0003120 obo:OBI_1110057 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ) ] ] ] ) ] . obo:OBI_1110129 obo:IAO_0000111 "assay measuring epitope specific cytokine production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope assay that detects cytokine production by T cells." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "cytokine release|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific cytokine production by T cells" ; rdfs:subClassOf obo:OBI_0002055 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001816 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110130 obo:IAO_0000111 "assay measuring epitope specific T cell killing" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope dependent biological activity assay that detects the killing of an antigen presenting cell (APC) by a T cell whose TCR recognizes an epitope presented by the APC." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "cytotoxicity|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific T cell killing" ; rdfs:subClassOf obo:OBI_0000882, obo:OBI_0002055 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000882 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001913 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110131 obo:IAO_0000111 "assay measuring epitope specific proliferation of T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A T cell epitope dependent biological activity assay that detects T cell proliferation." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "proliferation|biological activity" ; a owl:Class ; rdfs:label "assay measuring epitope specific proliferation of T cells" ; rdfs:subClassOf obo:OBI_0002055 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042098 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110132 obo:IAO_0000111 "obsolete CD8 receptor" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A transmembrane glycoprotein that serves as a co-receptor for the T cell receptor." ; obo:IAO_0000118 "CD8" ; obo:IAO_0000234 "https://github.com/obi-ontology/obi/issues/353" ; obo:IAO_0100001 obo:PR_000025402 ; a owl:Class ; rdfs:label "obsolete CD8 receptor" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:OBI_1110150 obo:IAO_0000111 "51 chromium assay measuring epitope specific T cell killing" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A chromium release assay that detects the killing of an antigen presenting cell (APC) by a T cell whose TCR recognizes an epitope presented by the APC." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "cytotoxicity|51 chromium" ; a owl:Class ; rdfs:label "51 chromium assay measuring epitope specific T cell killing" ; rdfs:subClassOf obo:OBI_0002062, obo:OBI_9999994 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_9999994 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001913 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom obo:OBI_0001876 ] ] ] ) ] . obo:OBI_1110151 obo:IAO_0000111 "ELISA measuring epitope specific interferon-gamma production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interferon-gamma production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IFNg release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interferon-gamma production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001414 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032609 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110152 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-2 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-2 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-2 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-2 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001445 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032623 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110153 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-4 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-4 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-4 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-4 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001450 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032633 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110154 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-5 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-5 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-5 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-5 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001230 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032634 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110155 obo:IAO_0000111 "ELISA measuring epitope specific tumor necrosis factor alpha production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects tumor necrosis factor alpha production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TNFa release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific tumor necrosis factor alpha production by T cells" ; rdfs:subClassOf obo:OBI_0001246, obo:OBI_0001416 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032640 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110156 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-10 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-10 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-10 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-10 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001209 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032613 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110157 obo:IAO_0000111 "ELISA measuring epitope specific granulocyte macrophage colony-stimulating factor production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects granulocyte macrophage colony stimulating factor production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "GM-CSF release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific granulocyte macrophage colony-stimulating factor production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001233 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032604 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110158 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-6 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-6 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-6 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-6 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001451 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032635 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110159 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-13 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-13 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-13 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-13 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001251 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032616 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110160 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-12 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-12 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-12 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-12 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001391 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032615 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110161 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-1 beta production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-1 beta production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-1b release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-1 beta production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001449 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032611 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110162 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-17 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-17 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-17 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-17 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001295 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032620 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110163 obo:IAO_0000111 "ELISA measuring epitope specific interleukin-18 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunosorbent assay that detects interleukin-18 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-18 release|ELISA" ; a owl:Class ; rdfs:label "ELISA measuring epitope specific interleukin-18 production by T cells" ; rdfs:subClassOf obo:OBI_0000661, obo:OBI_0001380 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000661 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032621 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110167 obo:IAO_0000111 "ELISPOT assay measuring epitope specific interleukin-4 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunospot assay that detects interleukin-4 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-4 release|ELISPOT" ; a owl:Class ; rdfs:label "ELISPOT assay measuring epitope specific interleukin-4 production by T cells" ; rdfs:subClassOf obo:OBI_0001450, obo:OBI_0600031 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600031 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032633 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110168 obo:IAO_0000111 "ELISPOT assay measuring epitope specific tumor necrosis factor alpha production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunospot assay that detects tumor necrosis factor alpha production by T cells" ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TNFa release|ELISPOT" ; a owl:Class ; rdfs:label "ELISPOT assay measuring epitope specific tumor necrosis factor alpha production by T cells" ; rdfs:subClassOf obo:OBI_0001272, obo:OBI_0001416 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600031 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032640 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110170 obo:IAO_0000111 "ELISPOT assay measuring epitope specific interleukin-10 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunospot assay that detects interleukin-10 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-10 release|ELISPOT" ; a owl:Class ; rdfs:label "ELISPOT assay measuring epitope specific interleukin-10 production by T cells" ; rdfs:subClassOf obo:OBI_0001209, obo:OBI_0600031 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600031 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032613 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110171 obo:IAO_0000111 "ELISPOT assay measuring epitope specific interleukin-13 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An enzyme-linked immunospot assay that detects interleukin-13 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-13 release|ELISPOT" ; a owl:Class ; rdfs:label "ELISPOT assay measuring epitope specific interleukin-13 production by T cells" ; rdfs:subClassOf obo:OBI_0001251, obo:OBI_0600031 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0600031 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032616 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110172 obo:IAO_0000111 "intracellular cytokine staining assay measuring epitope specific interferon-gamma production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects interferon-gamma production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IFNg release|ICS" ; a owl:Class ; rdfs:label "intracellular cytokine staining assay measuring epitope specific interferon-gamma production by T cells" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0001414 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032609 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110173 obo:IAO_0000111 "intracellular cytokine staining assay measuring epitope specific interleukin-2 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects interleukin-2 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-2 release|ICS" ; a owl:Class ; rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-2 production by T cells" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0001445 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032623 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110174 obo:IAO_0000111 "intracellular cytokine staining assay measuring epitope specific tumor necrosis factor alpha production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects tumor necrosis factor alpha production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "TNFa release|ICS" ; a owl:Class ; rdfs:label "intracellular cytokine staining assay measuring epitope specific tumor necrosis factor alpha production by T cells" ; rdfs:subClassOf obo:OBI_0001385, obo:OBI_0001416 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032640 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110175 obo:IAO_0000111 "intracellular cytokine staining assay measuring epitope specific interleukin-4 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects interleukin-4 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-4 release|ICS" ; a owl:Class ; rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-4 production by T cells" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0001450 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032633 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110177 obo:IAO_0000111 "intracellular cytokine staining assay measuring epitope specific interleukin-10 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects interleukin-10 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-10 release|ICS" ; a owl:Class ; rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-10 production by T cells" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0001209 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032613 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110178 obo:IAO_0000111 "intracellular cytokine staining assay measuring epitope specific interleukin-17 production by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A flow cytometry assay that detects interleukin-17 production by T cells." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "IL-17 release|ICS" ; a owl:Class ; rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-17 production by T cells" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0001295 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032620 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] ) ] . obo:OBI_1110179 obo:IAO_0000111 "MHC tetramer/multimer assay measuring binding of a T cell epitope:MHC:TCR complex" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A MHC tetramer/multimer assay that measures the binding of an epitope:MHC complex binding with a T cell receptor." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "qualitative binding|multimer/tetramer" ; a owl:Class ; rdfs:label "MHC tetramer/multimer assay measuring binding of a T cell epitope:MHC:TCR complex" ; rdfs:subClassOf obo:OBI_0000916, obo:OBI_0001501, obo:OBI_1110124 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000916 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000086 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0000788 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0000788 ] ) ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0003141 ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:OBI_1110057 ] ] ) ] . obo:OBI_1110180 obo:IAO_0000111 "3H-thymidine assay measuring epitope specific proliferation of T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A tritiated thymidine incorporation assay that detects T cell epitope specific proliferation in vitro." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "proliferation|3H-thymidine" ; a owl:Class ; rdfs:label "3H-thymidine assay measuring epitope specific proliferation of T cells" ; rdfs:subClassOf obo:OBI_0000669, obo:OBI_0002071 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000669 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042098 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom obo:OBI_0001876 ] ] ] ) ] . obo:OBI_1110181 obo:IAO_0000111 "BrdU assay measuring epitope specific proliferation of T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A BrdU incorporation assay that detects T cell epitope specific proliferation in vitro." ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; obo:OBI_9991118 "proliferation|BrdU" ; a owl:Class ; rdfs:label "BrdU assay measuring epitope specific proliferation of T cells" ; rdfs:subClassOf obo:OBI_0000664, obo:OBI_0002071 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000664 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042098 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:OBI_0003385 ; owl:someValuesFrom obo:OBI_0001876 ] ] ] ) ] . obo:OBI_1110182 obo:IAO_0000111 "epitope specific T cell proliferation" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A biological process where T cells proliferate resulting from the recognition of a T cell epitope."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "epitope specific T cell proliferation"@en ; rdfs:subClassOf obo:GO_0042098 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0042098 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_1110184 obo:IAO_0000111 "epitope specific GM-CSF release by T cells" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A biological process where T cells produce GM-CSF resulting from the recognition of a T cell epitope."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "epitope specific GM-CSF release by T cells"@en ; rdfs:subClassOf obo:GO_0032604, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032604 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_1110185 obo:IAO_0000111 "epitope specific IFN-g release by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A biological process where T cells produce IFNg resulting from the recognition of a T cell epitope."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "epitope specific IFN-g release by T cells"@en ; rdfs:subClassOf obo:GO_0032609, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032609 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_1110187 obo:IAO_0000111 "epitope specific IL-10 release by T cells" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A biological process where T cells produce IL-10 resulting from the recognition of a T cell epitope."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "epitope specific IL-10 release by T cells"@en ; rdfs:subClassOf obo:GO_0032613, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032613 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_1110190 obo:IAO_0000111 "epitope specific IL-12 release by T cells" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A biological process where T cells produce IL-12 resulting from the recognition of a T cell epitope."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "epitope specific IL-12 release by T cells"@en ; rdfs:subClassOf obo:GO_0032615, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032615 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_1110191 obo:IAO_0000111 "epitope specific IL-13 release by T cells" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A biological process where T cells produce IL-13 resulting from the recognition of a T cell epitope."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "epitope specific IL-13 release by T cells"@en ; rdfs:subClassOf obo:GO_0032616, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032616 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_1110193 obo:IAO_0000111 "epitope specific IL-17 release by T cells" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A biological process where T cells produce IL-17 resulting from the recognition of a T cell epitope."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "epitope specific IL-17 release by T cells"@en ; rdfs:subClassOf obo:GO_0032620, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032620 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_1110195 obo:IAO_0000111 "epitope specific IL-18 release by T cells" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A biological process where T cells produce IL-18 resulting from the recognition of a T cell epitope."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "epitope specific IL-18 release by T cells"@en ; rdfs:subClassOf obo:GO_0032621, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032621 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_1110196 obo:IAO_0000111 "epitope specific IL-1b release by T cells" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A biological process where T cells produce IL-1b resulting from the recognition of a T cell epitope."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "epitope specific IL-1b release by T cells"@en ; rdfs:subClassOf obo:GO_0032611, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032611 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_1110199 obo:IAO_0000111 "epitope specific IL-4 release by T cells" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A biological process where T cells produce IL-4 resulting from the recognition of a T cell epitope."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "epitope specific IL-4 release by T cells"@en ; rdfs:subClassOf obo:GO_0032633, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032633 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_1110201 obo:IAO_0000111 "allergen" ; obo:IAO_0000112 "Birch pollen is an allergen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A material entity bearing the disposition to cause an allergic reaction" ; obo:IAO_0000117 "IEDB" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "allergen" ; rdfs:subClassOf obo:BFO_0000040 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:OBI_1110010 ] ) ] . obo:OBI_1110202 obo:IAO_0000111 "epitope specific IL-5 release by T cells" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A biological process where T cells produce IL-5 resulting from the recognition of a T cell epitope."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "epitope specific IL-5 release by T cells"@en ; rdfs:subClassOf obo:GO_0032634, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032634 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_1110203 obo:IAO_0000111 "epitope specific IL-6 release by T cells" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A biological process where T cells produce IL-6 resulting from the recognition of a T cell epitope."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "epitope specific IL-6 release by T cells"@en ; rdfs:subClassOf obo:GO_0032635, obo:OBI_0001193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032635 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_1110204 obo:IAO_0000111 "epitope specific killing by T cells" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A biological process where T cells lyse antigen presenting cells resulting from the recognition of a T cell epitope on MHC molecules of the antigen presenting cell."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "epitope specific killing by T cells"@en ; rdfs:subClassOf obo:GO_0001913 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0001913 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_1110206 obo:IAO_0000111 "epitope specific TNF release by T cells" ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "A biological process where T cells produce TNF resulting from the recognition of a T cell epitope."@en ; obo:IAO_0000117 "IEDB"@en ; obo:IAO_0000119 "IEDB"@en ; a owl:Class ; rdfs:label "epitope specific TNF release by T cells"@en ; rdfs:subClassOf obo:GO_0032640, obo:OBI_0001351 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032640 [ a owl:Restriction ; owl:onProperty obo:OBI_1110060 ; owl:someValuesFrom obo:OBI_1110057 ] ) ] . obo:OBI_1110207 obo:IAO_0000111 "assay detecting IFN-gamma production" ; obo:IAO_0000112 "An IFN-g ELISPOT is an assay detecting ifn-gamma production" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An assay that determines information about the production of the cytokine interferon gamma" ; obo:IAO_0000117 "Bjoern Peters" ; obo:IAO_0000118 "IFNg release" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "assay detecting IFN-gamma production" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:IAO_0000109 [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0032609 ] ) ] ] ) ] . obo:OBI_1110300 obo:IAO_0000111 "direct submission to IEDB" ; obo:IAO_0000112 """The report on \"Identification of a dominant CD4 T cell epitope in the membrane lipoprotein Tul4 from Francisella tularensis LVS. \" submitted by Valentino et al to the IEDB. The content of that report on the IEDB website is here: http://iedb.org/refId/1013357""" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A report about experiments in an investigation that characterize immune epitopes, and was submitted directly by the authors to the Immune Epitope Database (IEDB)" ; obo:IAO_0000117 "PERSON: Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; a owl:Class ; rdfs:label "direct submission to IEDB" ; rdfs:subClassOf obo:IAO_0000088 . obo:OBI_1200000 obo:IAO_0000111 "FFPE specimen" ; obo:IAO_0000112 """Many of today’s researchers prefer to use Formalin-Fixed Paraffin-Embedded samples of tissues for their IHC, histological or in-situ genomic analyses. Professionally fixed and embedded FFPE samples and the biomolecules they contain are reasonably stable at ambient temperatures. -based on https://lab-ally.com/histopathology-resources/ffpe-samples/""" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that has been fixed in formalin and embedded in paraffin." ; obo:IAO_0000117 "MIABIS" ; obo:IAO_0000118 "formalin-fixed paraffin-embeded specimen" ; obo:IAO_0000119 ; obo:IAO_0000233 ; a owl:Class ; rdfs:label "FFPE specimen" ; rdfs:subClassOf obo:OBI_0000950 . obo:OBI_2000000 obo:IAO_0000111 "uterine cervix specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some uterine cervix" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "uterine cervix specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000002 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_2000001 obo:IAO_0000111 "urethra specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some urethra" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "urethra specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_2000002 obo:IAO_0000111 "cervical mucus specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some cervical mucus" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "cervical mucus specimen" ; rdfs:subClassOf obo:OBI_2000009 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0000316 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_2000003 obo:IAO_0000111 "throat specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some throat" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "throat specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000341 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_2000004 obo:IAO_0000111 "eye specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some eye" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "eye specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000970 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_2000005 obo:IAO_0000111 "respiratory system specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some respiratory system" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "respiratory system specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_2000006 obo:IAO_0000111 "upper respiratory tract specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some upper respiratory tract" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "upper respiratory tract specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001557 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_2000007 obo:IAO_0000111 "nasopharynx specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some nasopharynx" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "nasopharynx specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001728 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_2000008 obo:IAO_0000111 "semen specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some semen" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "semen specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0001968 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_2000009 obo:IAO_0000111 "bodily fluid specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some bodily fluid" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "bodily fluid specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0006314 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_2000010 obo:IAO_0000111 "chorionic villus specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some chorionic villus" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "chorionic villus specimen" ; rdfs:subClassOf obo:OBI_0001479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007106 ] ) ] ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_2000011 obo:IAO_0000111 "meconium specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some meconium" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "meconium specimen" ; rdfs:subClassOf obo:OBI_0002503 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0007109 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_2000012 obo:IAO_0000111 "umbilical cord blood specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some umbilical cord blood" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "umbilical cord blood specimen" ; rdfs:subClassOf obo:OBI_2000013 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0012168 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_2000013 obo:IAO_0000111 "arterial blood specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some arterial blood" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "arterial blood specimen" ; rdfs:subClassOf obo:OBI_2000009 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0013755 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_2000014 obo:IAO_0000111 "venous blood specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some venous blood" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "venous blood specimen" ; rdfs:subClassOf obo:OBI_2000009 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0013756 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_2000015 obo:IAO_0000111 "capillary blood specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some capillary blood" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "capillary blood specimen" ; rdfs:subClassOf obo:OBI_2000009 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0000659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:UBERON_0013757 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600005 ] ) ] ) ] . obo:OBI_2000016 obo:IAO_0000111 "erythrocyte specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some erythrocytes" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "erythrocyte specimen" ; rdfs:subClassOf obo:OBI_0002599, [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] ) ], [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CL_0000232 ] ) ] ] ) ] . obo:OBI_2000017 obo:IAO_0000111 "reticulocyte specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some reticulocytes" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "reticulocyte specimen" ; rdfs:subClassOf obo:OBI_0002599, [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] ) ], [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CL_0000558 ] ) ] ] ) ] . obo:OBI_2000018 obo:IAO_0000111 "leukocyte specimen" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A specimen that is derived from some leukocytes" ; obo:IAO_0000117 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; obo:IAO_0000119 "Christian Stoeckert ORCID:0000-0002-5714-991X", "Mark A. Miller ORCID:0000-0001-9076-6066" ; a owl:Class ; rdfs:label "leukocyte specimen" ; rdfs:subClassOf obo:OBI_0002599, [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0002600 ] ) ], [ a owl:Class ; owl:intersectionOf (obo:OBI_0100051 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000659 [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CL_0000738 ] ) ] ] ) ] . obo:OBI_2100001 obo:IAO_0000111 "carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "carbon dioxide assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ) ] . obo:OBI_2100002 obo:IAO_0000111 "sodium(1+) assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium(1+)" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "sodium(1+) assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ) ] . obo:OBI_2100003 obo:IAO_0000111 "creatinine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatinine" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "creatinine assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] ) ] . obo:OBI_2100004 obo:IAO_0000111 "potassium(1+) assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of potassium(1+)" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "potassium(1+) assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ) ] . obo:OBI_2100005 obo:IAO_0000111 "basophil count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of basophils" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "basophil count assay" ; rdfs:subClassOf obo:OBI_0003021, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000767 ] ] . obo:OBI_2100006 obo:IAO_0000111 "neutrophil count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of neutrophils" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "neutrophil count assay" ; rdfs:subClassOf obo:OBI_0003022, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000775 ] ] . obo:OBI_2100007 obo:IAO_0000111 "eosinophil count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of eosinophils" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "eosinophil count assay" ; rdfs:subClassOf obo:OBI_0003023, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000771 ] ] . obo:OBI_2100008 obo:IAO_0000111 "lymphocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of lymphocytes" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "lymphocyte count assay" ; rdfs:subClassOf obo:OBI_0003024, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000542 ] ] . obo:OBI_2100009 obo:IAO_0000111 "monocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of monocytes" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "monocyte count assay" ; rdfs:subClassOf obo:OBI_0003025, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000576 ] ] . obo:OBI_2100010 obo:IAO_0000111 "chloride assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of chloride" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chloride assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] ) ] . obo:OBI_2100011 obo:IAO_0000111 "erythrocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of erythrocytes" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "erythrocyte count assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000232 ] ] . obo:OBI_2100012 obo:IAO_0000111 "platelet count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of platelets" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "platelet count assay" ; rdfs:subClassOf obo:OBI_0003028, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000233 ] ] . obo:OBI_2100013 obo:IAO_0000111 "leukocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of leukocytes" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "leukocyte count assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000738 ] ] . obo:OBI_2100014 obo:IAO_0000111 "hemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of hemoglobin" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "hemoglobin assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] ) ] . obo:OBI_2100015 obo:IAO_0000111 "phosphate ion assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of phosphate ion" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "phosphate ion assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35780 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35780 ] ) ] ) ] . obo:OBI_2100016 obo:IAO_0000111 "alanine aminotransferase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of alanine aminotransferase" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "alanine aminotransferase assay" ; rdfs:subClassOf obo:OBI_2100023 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050219 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050219 ] ) ] ) ] . obo:OBI_2100017 obo:IAO_0000111 "alkaline phosphatase (human) assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of alkaline phosphatase (human)" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "alkaline phosphatase (human) assay" ; rdfs:subClassOf obo:OBI_2100023 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050343 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050343 ] ) ] ) ] . obo:OBI_2100018 obo:IAO_0000111 "bilirubin IXalpha assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bilirubin IXalpha" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "bilirubin IXalpha assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16990 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16990 ] ) ] ) ] . obo:OBI_2100019 obo:IAO_0000111 "aspartate aminotransferase (human) assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of aspartate aminotransferase (human)" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "aspartate aminotransferase (human) assay" ; rdfs:subClassOf obo:OBI_2100023 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050353 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050353 ] ) ] ) ] . obo:OBI_2100020 obo:IAO_0000111 "glucose assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of glucose" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "glucose assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ) ] . obo:OBI_2100021 obo:IAO_0000111 "magnesium cation assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of magnesium cation" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "magnesium cation assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39127 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39127 ] ) ] ) ] . obo:OBI_2100022 obo:IAO_0000111 "albumin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of albumin" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "albumin assay" ; rdfs:subClassOf obo:OBI_2100023 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003918 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003918 ] ) ] ) ] . obo:OBI_2100023 obo:IAO_0000111 "protein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of protein" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "protein assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ) ] . obo:OBI_2100024 obo:IAO_0000111 "calcium cation assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of calcium cation" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "calcium cation assay" ; rdfs:subClassOf obo:OBI_0003012 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ) ] . obo:OBI_2100025 obo:IAO_0000111 "creatine kinase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatine kinase" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "creatine kinase assay" ; rdfs:subClassOf obo:OBI_2100023 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000029971 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000029971 ] ) ] ) ] . obo:OBI_2100026 obo:IAO_0000111 "nucleate erythrocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of nucleate erythrocytes" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "nucleate erythrocyte count assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000562 ] ] . obo:OBI_2100027 obo:IAO_0000111 "segmented neutrophil of bone marrow count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of segmented neutrophil of bone marrows" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "segmented neutrophil of bone marrow count assay" ; rdfs:subClassOf obo:OBI_0003022, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0011114 ] ] . obo:OBI_2100028 obo:IAO_0000111 "lactate dehydrogenase complex assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures lactate dehydrogenase complex" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "lactate dehydrogenase complex assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PR_000050331 ] ] ) ] . obo:OBI_2100029 obo:IAO_0000111 "triglyceride assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of triglyceride" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "triglyceride assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17855 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17855 ] ) ] ) ] . obo:OBI_2100030 obo:IAO_0000111 "high-density lipoprotein cholesterol assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of high-density lipoprotein cholesterol" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "high-density lipoprotein cholesterol assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_47775 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_47775 ] ) ] ) ] . obo:OBI_2100031 obo:IAO_0000111 "cholesterol assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of cholesterol" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "cholesterol assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16113 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16113 ] ) ] ) ] . obo:OBI_2100032 obo:IAO_0000111 "low-density lipoprotein cholesterol assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of low-density lipoprotein cholesterol" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "low-density lipoprotein cholesterol assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_47774 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_47774 ] ) ] ) ] . obo:OBI_2100033 obo:IAO_0000111 "thyroid stimulating hormone assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of thyroid stimulating hormone" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "thyroid stimulating hormone assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_81567 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_81567 ] ) ] ) ] . obo:OBI_2100034 obo:IAO_0000111 "prostate-specific antigen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of prostate-specific antigen" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "prostate-specific antigen assay" ; rdfs:subClassOf obo:OBI_2100023 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003015 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003015 ] ) ] ) ] . obo:OBI_2100035 obo:IAO_0000111 "thyroxine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of thyroxine" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "thyroxine assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_30660 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_30660 ] ) ] ) ] . obo:OBI_2100036 obo:IAO_0000111 "elemental oxygen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of elemental oxygen" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "elemental oxygen assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] ) ] . obo:OBI_2100037 obo:IAO_0000111 "folic acids assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of folic acids" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "folic acids assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_37445 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_37445 ] ) ] ) ] . obo:OBI_2100038 obo:IAO_0000111 "reticulocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of reticulocytes" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "reticulocyte count assay" ; rdfs:subClassOf obo:OBI_0003026, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000558 ] ] . obo:OBI_2100039 obo:IAO_0000111 "osmolality assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures osmolality" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "osmolality assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PATO_0002027 ] ] ) ] . obo:OBI_2100040 obo:IAO_0000111 "methemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of methemoglobin" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "methemoglobin assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17423 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17423 ] ) ] ) ] . obo:OBI_2100041 obo:IAO_0000111 "cytosolic creatine kinase complex, MB-type assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures cytosolic creatine kinase complex, MB-type" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "cytosolic creatine kinase complex, MB-type assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PR_000027247 ] ] ) ] . obo:OBI_2100042 obo:IAO_0000111 "rac-lactic acid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures rac-lactic acid" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "rac-lactic acid assay" ; rdfs:subClassOf obo:OBI_0000070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000070 [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CHEBI_28358 ] ] ) ] . obo:OBI_2100043 obo:IAO_0000111 "hydrogencarbonate assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of hydrogencarbonate" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "hydrogencarbonate assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] ) ] . obo:OBI_2100044 obo:IAO_0000111 "vancomycin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of vancomycin" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "vancomycin assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_28001 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_28001 ] ) ] ) ] . obo:OBI_2100045 obo:IAO_0000111 "tobramycin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of tobramycin" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "tobramycin assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_28864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_28864 ] ) ] ) ] . obo:OBI_2100046 obo:IAO_0000111 "3,3',5'-triiodothyronine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of 3,3',5'-triiodothyronine" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "3,3',5'-triiodothyronine assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_28774 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_28774 ] ) ] ) ] . obo:OBI_2100047 obo:IAO_0000111 "C-reactive protein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of C-reactive protein" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "C-reactive protein assay" ; rdfs:subClassOf obo:OBI_2100023 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000005897 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000005897 ] ) ] ) ] . obo:OBI_2100048 obo:IAO_0000111 "megakaryocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of megakaryocytes" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "megakaryocyte count assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000556 ] ] . obo:OBI_2100049 obo:IAO_0000111 "mesothelial cell count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of mesothelial cells" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "mesothelial cell count assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000077 ] ] . obo:OBI_2100050 obo:IAO_0000111 "macrophage count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of macrophages" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "macrophage count assay" ; rdfs:subClassOf obo:OBI_0003027, [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000235 ] ] . obo:OBI_2100051 obo:IAO_0000111 "3-hydroxybutyric acid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of 3-hydroxybutyric acid" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "3-hydroxybutyric acid assay" ; rdfs:subClassOf obo:OBI_0000443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:OBI_0000443 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_20067 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_20067 ] ) ] ) ] . obo:OBI_2100052 obo:IAO_0000111 "panel5 venous blood carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a panel5 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "panel5 venous blood carbon dioxide assay" ; rdfs:subClassOf obo:OBI_2100001, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:OBI_2100053 obo:IAO_0000111 "panel5 venous blood sodium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium in venous blood as part of a panel5 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "panel5 venous blood sodium assay" ; rdfs:subClassOf obo:OBI_2100002, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] . obo:OBI_2100054 obo:IAO_0000111 "panel5 venous blood creatinine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatinine in venous blood as part of a panel5 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "panel5 venous blood creatinine assay" ; rdfs:subClassOf obo:OBI_2100003, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] . obo:OBI_2100055 obo:IAO_0000111 "panel5 venous blood potassium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of potassium in venous blood as part of a panel5 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "panel5 venous blood potassium assay" ; rdfs:subClassOf obo:OBI_2100004, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] . obo:OBI_2100056 obo:IAO_0000111 "automated differential venous blood basophil count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of basophils in venous blood as part of a automated differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "automated differential venous blood basophil count assay" ; rdfs:subClassOf obo:OBI_0003021, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000767 ] ] . obo:OBI_2100057 obo:IAO_0000111 "automated differential venous blood neutrophil count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of neutrophils in venous blood as part of a automated differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "automated differential venous blood neutrophil count assay" ; rdfs:subClassOf obo:OBI_0003022, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000775 ] ] . obo:OBI_2100058 obo:IAO_0000111 "automated differential venous blood eosinophil count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of eosinophils in venous blood as part of a automated differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "automated differential venous blood eosinophil count assay" ; rdfs:subClassOf obo:OBI_0003023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000771 ] ] . obo:OBI_2100059 obo:IAO_0000111 "automated differential venous blood lymphocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of lymphocytes in venous blood as part of a automated differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "automated differential venous blood lymphocyte count assay" ; rdfs:subClassOf obo:OBI_0003024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000542 ] ] . obo:OBI_2100060 obo:IAO_0000111 "automated differential venous blood monocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of monocytes in venous blood as part of a automated differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "automated differential venous blood monocyte count assay" ; rdfs:subClassOf obo:OBI_0003025, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000576 ] ] . obo:OBI_2100061 obo:IAO_0000111 "venous blood chloride assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of chloride in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood chloride assay" ; rdfs:subClassOf obo:OBI_2100010, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] . obo:OBI_2100062 obo:IAO_0000111 "CBC with automated differential venous blood RBC count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of RBCs in venous blood as part of a CBC with automated differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with automated differential venous blood RBC count assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000232 ] ] . obo:OBI_2100063 obo:IAO_0000111 "CBC with automated differential venous blood platelet count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of platelets in venous blood as part of a CBC with automated differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with automated differential venous blood platelet count assay" ; rdfs:subClassOf obo:OBI_0003028, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000233 ] ] . obo:OBI_2100064 obo:IAO_0000111 "CBC with automated differential venous blood WBC count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of WBCs in venous blood as part of a CBC with automated differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with automated differential venous blood WBC count assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000738 ] ] . obo:OBI_2100065 obo:IAO_0000111 "CBC with automated differential venous blood hematocrit assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the proportion of red blood cells in venous blood as part of a CBC with automated differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with automated differential venous blood hematocrit assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000232 ] ] . obo:OBI_2100066 obo:IAO_0000111 "CBC with automated differential venous blood hemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of hemoglobin in venous blood as part of a CBC with automated differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with automated differential venous blood hemoglobin assay" ; rdfs:subClassOf obo:OBI_2100014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] . obo:OBI_2100067 obo:IAO_0000111 "venous blood phosphate assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of phosphate in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood phosphate assay" ; rdfs:subClassOf obo:OBI_2100015, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35780 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35780 ] ) ] . obo:OBI_2100068 obo:IAO_0000111 "liver injury venous blood alanine aminotransferase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of alanine aminotransferase in venous blood as part of a liver injury order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver injury venous blood alanine aminotransferase assay" ; rdfs:subClassOf obo:OBI_2100016, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050219 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050219 ] ) ] . obo:OBI_2100069 obo:IAO_0000111 "liver injury venous blood human alkaline phosphatase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of human alkaline phosphatase in venous blood as part of a liver injury order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver injury venous blood human alkaline phosphatase assay" ; rdfs:subClassOf obo:OBI_2100017, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050343 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050343 ] ) ] . obo:OBI_2100070 obo:IAO_0000111 "liver injury venous blood bilirubin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bilirubin in venous blood as part of a liver injury order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver injury venous blood bilirubin assay" ; rdfs:subClassOf obo:OBI_2100018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16990 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16990 ] ) ] . obo:OBI_2100071 obo:IAO_0000111 "liver injury venous blood human aspartate aminotransferase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of human aspartate aminotransferase in venous blood as part of a liver injury order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver injury venous blood human aspartate aminotransferase assay" ; rdfs:subClassOf obo:OBI_2100019, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050353 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050353 ] ) ] . obo:OBI_2100072 obo:IAO_0000111 "venous blood glucose assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of glucose in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood glucose assay" ; rdfs:subClassOf obo:OBI_2100020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] . obo:OBI_2100073 obo:IAO_0000111 "venous blood magnesium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of magnesium in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood magnesium assay" ; rdfs:subClassOf obo:OBI_2100021, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39127 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39127 ] ) ] . obo:OBI_2100074 obo:IAO_0000111 "CBC venous blood RBC count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of RBCs in venous blood as part of a CBC order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC venous blood RBC count assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000232 ] ] . obo:OBI_2100075 obo:IAO_0000111 "CBC venous blood WBC count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of WBCs in venous blood as part of a CBC order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC venous blood WBC count assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000738 ] ] . obo:OBI_2100076 obo:IAO_0000111 "CBC venous blood hematocrit assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the proportion of red blood cells in venous blood as part of a CBC order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC venous blood hematocrit assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000232 ] ] . obo:OBI_2100077 obo:IAO_0000111 "CBC venous blood platelet count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of platelets in venous blood as part of a CBC order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC venous blood platelet count assay" ; rdfs:subClassOf obo:OBI_0003028, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000233 ] ] . obo:OBI_2100078 obo:IAO_0000111 "CBC venous blood hemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of hemoglobin in venous blood as part of a CBC order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC venous blood hemoglobin assay" ; rdfs:subClassOf obo:OBI_2100014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] . obo:OBI_2100079 obo:IAO_0000111 "corrected venous blood leukocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of leukocytes in venous blood as part of a corrected order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "corrected venous blood leukocyte count assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000738 ] ] . obo:OBI_2100080 obo:IAO_0000111 "liver evaluation venous blood bilirubin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bilirubin in venous blood as part of a liver evaluation order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver evaluation venous blood bilirubin assay" ; rdfs:subClassOf obo:OBI_2100018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16990 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16990 ] ) ] . obo:OBI_2100081 obo:IAO_0000111 "liver evaluation venous blood globulin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of globulin in venous blood as part of a liver evaluation order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver evaluation venous blood globulin assay" ; rdfs:subClassOf obo:OBI_0003015, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_166899 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_166899 ] ) ] . obo:OBI_2100082 obo:IAO_0000111 "liver evaluation venous blood albumin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of albumin in venous blood as part of a liver evaluation order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver evaluation venous blood albumin assay" ; rdfs:subClassOf obo:OBI_2100022, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003918 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003918 ] ) ] . obo:OBI_2100083 obo:IAO_0000111 "liver evaluation venous blood human aspartate aminotransferase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of human aspartate aminotransferase in venous blood as part of a liver evaluation order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver evaluation venous blood human aspartate aminotransferase assay" ; rdfs:subClassOf obo:OBI_2100019, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050353 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050353 ] ) ] . obo:OBI_2100084 obo:IAO_0000111 "liver evaluation venous blood alanine aminotransferase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of alanine aminotransferase in venous blood as part of a liver evaluation order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver evaluation venous blood alanine aminotransferase assay" ; rdfs:subClassOf obo:OBI_2100016, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050219 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050219 ] ) ] . obo:OBI_2100085 obo:IAO_0000111 "liver evaluation venous blood human alkaline phosphatase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of human alkaline phosphatase in venous blood as part of a liver evaluation order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver evaluation venous blood human alkaline phosphatase assay" ; rdfs:subClassOf obo:OBI_2100017, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050343 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050343 ] ) ] . obo:OBI_2100086 obo:IAO_0000111 "liver evaluation venous blood protein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of protein in venous blood as part of a liver evaluation order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver evaluation venous blood protein assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000000001 ] ) ] . obo:OBI_2100087 obo:IAO_0000111 "basic metabolic panel venous blood chloride assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of chloride in venous blood as part of a basic metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "basic metabolic panel venous blood chloride assay" ; rdfs:subClassOf obo:OBI_2100010, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] . obo:OBI_2100088 obo:IAO_0000111 "basic metabolic panel venous blood potassium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of potassium in venous blood as part of a basic metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "basic metabolic panel venous blood potassium assay" ; rdfs:subClassOf obo:OBI_2100004, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] . obo:OBI_2100089 obo:IAO_0000111 "basic metabolic panel venous blood sodium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium in venous blood as part of a basic metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "basic metabolic panel venous blood sodium assay" ; rdfs:subClassOf obo:OBI_2100002, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] . obo:OBI_2100090 obo:IAO_0000111 "basic metabolic panel venous blood creatinine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatinine in venous blood as part of a basic metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "basic metabolic panel venous blood creatinine assay" ; rdfs:subClassOf obo:OBI_2100003, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] . obo:OBI_2100091 obo:IAO_0000111 "basic metabolic panel venous blood glucose assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of glucose in venous blood as part of a basic metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "basic metabolic panel venous blood glucose assay" ; rdfs:subClassOf obo:OBI_2100020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] . obo:OBI_2100092 obo:IAO_0000111 "basic metabolic panel venous blood calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of calcium in venous blood as part of a basic metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "basic metabolic panel venous blood calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100093 obo:IAO_0000111 "basic metabolic panel venous blood carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a basic metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "basic metabolic panel venous blood carbon dioxide assay" ; rdfs:subClassOf obo:OBI_2100001, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:OBI_2100094 obo:IAO_0000111 "venous blood creatine kinase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatine kinase in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood creatine kinase assay" ; rdfs:subClassOf obo:OBI_2100025, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000029971 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000029971 ] ) ] . obo:OBI_2100095 obo:IAO_0000111 "venous blood calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of calcium in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100096 obo:IAO_0000111 "venous blood ferritin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures ferritin in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood ferritin assay" ; rdfs:subClassOf obo:OBI_0003009, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0070288 ] ] . obo:OBI_2100097 obo:IAO_0000111 "total venous blood calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of calcium in venous blood as part of a total order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "total venous blood calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100098 obo:IAO_0000111 "venous blood iron assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of iron in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood iron assay" ; rdfs:subClassOf obo:OBI_0003011, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_24875 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_24875 ] ) ] . obo:OBI_2100099 obo:IAO_0000111 "CBC with manual differential venous blood band neutrophil count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of band neutrophils in venous blood as part of a CBC with manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with manual differential venous blood band neutrophil count assay" ; rdfs:subClassOf obo:OBI_0003022, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000560 ] ] . obo:OBI_2100100 obo:IAO_0000111 "CBC with manual differential venous blood WBC count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of WBCs in venous blood as part of a CBC with manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with manual differential venous blood WBC count assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000738 ] ] . obo:OBI_2100101 obo:IAO_0000111 "CBC with manual differential venous blood eosinophil count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of eosinophils in venous blood as part of a CBC with manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with manual differential venous blood eosinophil count assay" ; rdfs:subClassOf obo:OBI_0003023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000771 ] ] . obo:OBI_2100102 obo:IAO_0000111 "CBC with manual differential venous blood lymphocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of lymphocytes in venous blood as part of a CBC with manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with manual differential venous blood lymphocyte count assay" ; rdfs:subClassOf obo:OBI_0003024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000542 ] ] . obo:OBI_2100103 obo:IAO_0000111 "CBC with manual differential venous blood nucleated RBC count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of nucleated RBCs in venous blood as part of a CBC with manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with manual differential venous blood nucleated RBC count assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000562 ] ] . obo:OBI_2100104 obo:IAO_0000111 "CBC with manual differential venous blood monocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of monocytes in venous blood as part of a CBC with manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with manual differential venous blood monocyte count assay" ; rdfs:subClassOf obo:OBI_0003025, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000576 ] ] . obo:OBI_2100105 obo:IAO_0000111 "CBC with manual differential venous blood segmented neutrophil count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of segmented neutrophils in venous blood as part of a CBC with manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with manual differential venous blood segmented neutrophil count assay" ; rdfs:subClassOf obo:OBI_0003022, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0011114 ] ] . obo:OBI_2100106 obo:IAO_0000111 "CBC with manual differential venous blood basophil count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of basophils in venous blood as part of a CBC with manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with manual differential venous blood basophil count assay" ; rdfs:subClassOf obo:OBI_0003021, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000767 ] ] . obo:OBI_2100107 obo:IAO_0000111 "venous blood albumin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of albumin in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood albumin assay" ; rdfs:subClassOf obo:OBI_2100022, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003918 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003918 ] ) ] . obo:OBI_2100108 obo:IAO_0000111 "cardiac enzymes venous blood creatine kinase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatine kinase in venous blood as part of a cardiac enzymes order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "cardiac enzymes venous blood creatine kinase assay" ; rdfs:subClassOf obo:OBI_2100025, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000029971 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000029971 ] ) ] . obo:OBI_2100109 obo:IAO_0000111 "venous blood haptoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of haptoglobin in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood haptoglobin assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000008725 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000008725 ] ) ] . obo:OBI_2100110 obo:IAO_0000111 "venous blood lactate dehydrogenase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures lactate dehydrogenase in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood lactate dehydrogenase assay" ; rdfs:subClassOf obo:OBI_2100028, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PR_000050331 ] ] . obo:OBI_2100111 obo:IAO_0000111 "venous blood prealbunin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of prealbunin in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood prealbunin assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000016801 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000016801 ] ) ] . obo:OBI_2100112 obo:IAO_0000111 "lipid panel venous blood triglyceride assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of triglyceride in venous blood as part of a lipid panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "lipid panel venous blood triglyceride assay" ; rdfs:subClassOf obo:OBI_2100029, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17855 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17855 ] ) ] . obo:OBI_2100113 obo:IAO_0000111 "lipid panel venous blood high density lipoprotein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of high density lipoprotein in venous blood as part of a lipid panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "lipid panel venous blood high density lipoprotein assay" ; rdfs:subClassOf obo:OBI_2100030, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_47775 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_47775 ] ) ] . obo:OBI_2100114 obo:IAO_0000111 "lipid panel venous blood cholesterol assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of cholesterol in venous blood as part of a lipid panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "lipid panel venous blood cholesterol assay" ; rdfs:subClassOf obo:OBI_2100031, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16113 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16113 ] ) ] . obo:OBI_2100115 obo:IAO_0000111 "lipid panel venous blood low density lipoprotein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of low density lipoprotein in venous blood as part of a lipid panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "lipid panel venous blood low density lipoprotein assay" ; rdfs:subClassOf obo:OBI_2100032, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_47774 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_47774 ] ) ] . obo:OBI_2100116 obo:IAO_0000111 "venous blood hemoglobin A1c assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures hemoglobin A1c in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood hemoglobin A1c assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PR_000050469 ] ] . obo:OBI_2100117 obo:IAO_0000111 "venous blood uric acid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of uric acid in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood uric acid assay" ; rdfs:subClassOf obo:OBI_0003014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_27226 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_27226 ] ) ] . obo:OBI_2100118 obo:IAO_0000111 "total venous blood protein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of protein in venous blood as part of a total order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "total venous blood protein assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000000001 ] ) ] . obo:OBI_2100119 obo:IAO_0000111 "venous blood thyroid stimulating hormone assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of thyroid stimulating hormone in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood thyroid stimulating hormone assay" ; rdfs:subClassOf obo:OBI_2100033, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_81567 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_81567 ] ) ] . obo:OBI_2100120 obo:IAO_0000111 "venous blood prostate specific antigen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of prostate specific antigen in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood prostate specific antigen assay" ; rdfs:subClassOf obo:OBI_2100034, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003015 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003015 ] ) ] . obo:OBI_2100121 obo:IAO_0000111 "24 hour total urine volume assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures volume in urine as part of a 24 hour total order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "24 hour total urine volume assay" ; rdfs:subClassOf obo:OBI_0003043, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000651 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000651 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PATO_0000918 ] ] . obo:OBI_2100122 obo:IAO_0000111 "T4 uptake venous blood T4 assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of T4 in venous blood as part of a T4 uptake order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "T4 uptake venous blood T4 assay" ; rdfs:subClassOf obo:OBI_2100035, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_30660 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_30660 ] ) ] . obo:OBI_2100123 obo:IAO_0000111 "arterial blood glucose assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of glucose in arterial blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "arterial blood glucose assay" ; rdfs:subClassOf obo:OBI_2100020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] . obo:OBI_2100124 obo:IAO_0000111 "CBC with manual differential venous blood cell count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of cells in venous blood as part of a CBC with manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with manual differential venous blood cell count assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000000 ] ] . obo:OBI_2100125 obo:IAO_0000111 "hemoglobin oxygen saturation arterial blood oxygen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of oxygen in arterial blood as part of a hemoglobin oxygen saturation order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "hemoglobin oxygen saturation arterial blood oxygen assay" ; rdfs:subClassOf obo:OBI_2100036, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] . obo:OBI_2100126 obo:IAO_0000111 "hemoglobin oxygen saturation arterial blood hemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of hemoglobin in arterial blood as part of a hemoglobin oxygen saturation order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "hemoglobin oxygen saturation arterial blood hemoglobin assay" ; rdfs:subClassOf obo:OBI_2100014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] . obo:OBI_2100127 obo:IAO_0000111 "inpatient profile venous blood sodium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium in venous blood as part of a inpatient profile order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "inpatient profile venous blood sodium assay" ; rdfs:subClassOf obo:OBI_2100002, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] . obo:OBI_2100128 obo:IAO_0000111 "inpatient profile venous blood creatinine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatinine in venous blood as part of a inpatient profile order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "inpatient profile venous blood creatinine assay" ; rdfs:subClassOf obo:OBI_2100003, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] . obo:OBI_2100129 obo:IAO_0000111 "inpatient profile venous blood potassium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of potassium in venous blood as part of a inpatient profile order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "inpatient profile venous blood potassium assay" ; rdfs:subClassOf obo:OBI_2100004, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] . obo:OBI_2100130 obo:IAO_0000111 "inpatient profile venous blood carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a inpatient profile order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "inpatient profile venous blood carbon dioxide assay" ; rdfs:subClassOf obo:OBI_2100001, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:OBI_2100131 obo:IAO_0000111 "venous blood folic acid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of folic acid in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood folic acid assay" ; rdfs:subClassOf obo:OBI_2100037, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_37445 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_37445 ] ) ] . obo:OBI_2100132 obo:IAO_0000111 "count venous blood reticulocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of reticulocytes in venous blood as part of a count order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "count venous blood reticulocyte count assay" ; rdfs:subClassOf obo:OBI_0003026, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000558 ] ] . obo:OBI_2100133 obo:IAO_0000111 "venous blood potassium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of potassium in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood potassium assay" ; rdfs:subClassOf obo:OBI_2100004, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] . obo:OBI_2100134 obo:IAO_0000111 "venous blood carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood carbon dioxide assay" ; rdfs:subClassOf obo:OBI_2100001, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:OBI_2100135 obo:IAO_0000111 "venous blood transferrin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of transferrin in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood transferrin assay" ; rdfs:subClassOf obo:OBI_0003013, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000016261 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000016261 ] ) ] . obo:OBI_2100136 obo:IAO_0000111 "venous blood sodium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood sodium assay" ; rdfs:subClassOf obo:OBI_2100002, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] . obo:OBI_2100137 obo:IAO_0000111 "random electrolytes urine sodium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium in urine as part of a random electrolytes order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "random electrolytes urine sodium assay" ; rdfs:subClassOf obo:OBI_0003043, obo:OBI_2100002, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000651 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000651 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] . obo:OBI_2100138 obo:IAO_0000111 "random electrolytes urine potassium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of potassium in urine as part of a random electrolytes order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "random electrolytes urine potassium assay" ; rdfs:subClassOf obo:OBI_0003043, obo:OBI_2100004, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000651 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000651 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] . obo:OBI_2100139 obo:IAO_0000111 "urine creatinine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatinine in urine" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "urine creatinine assay" ; rdfs:subClassOf obo:OBI_0003043, obo:OBI_2100003, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000651 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000651 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] . obo:OBI_2100140 obo:IAO_0000111 "urine osmolality assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures osmolality in urine" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "urine osmolality assay" ; rdfs:subClassOf obo:OBI_0003043, obo:OBI_2100039, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000651 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000651 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PATO_0002027 ] ] . obo:OBI_2100141 obo:IAO_0000111 "cooximitery arterial blood oxygen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of oxygen in arterial blood as part of a cooximitery order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "cooximitery arterial blood oxygen assay" ; rdfs:subClassOf obo:OBI_2100036, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] . obo:OBI_2100142 obo:IAO_0000111 "cooximitery arterial blood hemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of hemoglobin in arterial blood as part of a cooximitery order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "cooximitery arterial blood hemoglobin assay" ; rdfs:subClassOf obo:OBI_2100014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] . obo:OBI_2100143 obo:IAO_0000111 "cooximitery arterial blood methemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of methemoglobin in arterial blood as part of a cooximitery order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "cooximitery arterial blood methemoglobin assay" ; rdfs:subClassOf obo:OBI_2100040, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17423 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17423 ] ) ] . obo:OBI_2100144 obo:IAO_0000111 "electrolytes urine sodium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium in urine as part of a electrolytes order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "electrolytes urine sodium assay" ; rdfs:subClassOf obo:OBI_0003043, obo:OBI_2100002, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000651 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000651 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] . obo:OBI_2100145 obo:IAO_0000111 "electrolytes urine potassium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of potassium in urine as part of a electrolytes order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "electrolytes urine potassium assay" ; rdfs:subClassOf obo:OBI_0003043, obo:OBI_2100004, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000651 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000651 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] . obo:OBI_2100146 obo:IAO_0000111 "Biosite cardiac panel arterial blood creatine kinase MB assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures creatine kinase MB in arterial blood as part of a Biosite cardiac panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "Biosite cardiac panel arterial blood creatine kinase MB assay" ; rdfs:subClassOf obo:OBI_2100041, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PR_000027247 ] ] . obo:OBI_2100147 obo:IAO_0000111 "venous blood fibrinogen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures fibrinogen in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood fibrinogen assay" ; rdfs:subClassOf obo:OBI_0003010, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0005577 ] ] . obo:OBI_2100148 obo:IAO_0000111 "comprehensive metabolic panel venous blood carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a comprehensive metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "comprehensive metabolic panel venous blood carbon dioxide assay" ; rdfs:subClassOf obo:OBI_2100001, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:OBI_2100149 obo:IAO_0000111 "comprehensive metabolic panel venous blood calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of calcium in venous blood as part of a comprehensive metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "comprehensive metabolic panel venous blood calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100150 obo:IAO_0000111 "comprehensive metabolic panel venous blood potassium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of potassium in venous blood as part of a comprehensive metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "comprehensive metabolic panel venous blood potassium assay" ; rdfs:subClassOf obo:OBI_2100004, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] . obo:OBI_2100151 obo:IAO_0000111 "comprehensive metabolic panel venous blood sodium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium in venous blood as part of a comprehensive metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "comprehensive metabolic panel venous blood sodium assay" ; rdfs:subClassOf obo:OBI_2100002, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] . obo:OBI_2100152 obo:IAO_0000111 "comprehensive metabolic panel venous blood glucose assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of glucose in venous blood as part of a comprehensive metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "comprehensive metabolic panel venous blood glucose assay" ; rdfs:subClassOf obo:OBI_2100020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] . obo:OBI_2100153 obo:IAO_0000111 "comprehensive metabolic panel venous blood albumin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of albumin in venous blood as part of a comprehensive metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "comprehensive metabolic panel venous blood albumin assay" ; rdfs:subClassOf obo:OBI_2100022, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003918 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003918 ] ) ] . obo:OBI_2100154 obo:IAO_0000111 "comprehensive metabolic panel venous blood human alkaline phosphatase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of human alkaline phosphatase in venous blood as part of a comprehensive metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "comprehensive metabolic panel venous blood human alkaline phosphatase assay" ; rdfs:subClassOf obo:OBI_2100017, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050343 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050343 ] ) ] . obo:OBI_2100155 obo:IAO_0000111 "comprehensive metabolic panel venous blood bilirubin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bilirubin in venous blood as part of a comprehensive metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "comprehensive metabolic panel venous blood bilirubin assay" ; rdfs:subClassOf obo:OBI_2100018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16990 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16990 ] ) ] . obo:OBI_2100156 obo:IAO_0000111 "comprehensive metabolic panel venous blood chloride assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of chloride in venous blood as part of a comprehensive metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "comprehensive metabolic panel venous blood chloride assay" ; rdfs:subClassOf obo:OBI_2100010, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] . obo:OBI_2100157 obo:IAO_0000111 "comprehensive metabolic panel venous blood human aspartate aminotransferase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of human aspartate aminotransferase in venous blood as part of a comprehensive metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "comprehensive metabolic panel venous blood human aspartate aminotransferase assay" ; rdfs:subClassOf obo:OBI_2100019, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050353 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050353 ] ) ] . obo:OBI_2100158 obo:IAO_0000111 "comprehensive metabolic panel venous blood protein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of protein in venous blood as part of a comprehensive metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "comprehensive metabolic panel venous blood protein assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000000001 ] ) ] . obo:OBI_2100159 obo:IAO_0000111 "comprehensive metabolic panel venous blood creatinine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatinine in venous blood as part of a comprehensive metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "comprehensive metabolic panel venous blood creatinine assay" ; rdfs:subClassOf obo:OBI_2100003, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] . obo:OBI_2100160 obo:IAO_0000111 "comprehensive metabolic panel venous blood alanine aminotransferase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of alanine aminotransferase in venous blood as part of a comprehensive metabolic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "comprehensive metabolic panel venous blood alanine aminotransferase assay" ; rdfs:subClassOf obo:OBI_2100016, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050219 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050219 ] ) ] . obo:OBI_2100161 obo:IAO_0000111 "venous blood LDH assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures LDH in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood LDH assay" ; rdfs:subClassOf obo:OBI_2100028, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PR_000050331 ] ] . obo:OBI_2100162 obo:IAO_0000111 "venous blood creatine kinase MB assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures creatine kinase MB in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood creatine kinase MB assay" ; rdfs:subClassOf obo:OBI_2100041, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PR_000027247 ] ] . obo:OBI_2100163 obo:IAO_0000111 "venous blood lactic acid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures lactic acid in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood lactic acid assay" ; rdfs:subClassOf obo:OBI_2100042, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CHEBI_28358 ] ] . obo:OBI_2100164 obo:IAO_0000111 "venous blood hematocrit assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the proportion of red blood cells in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood hematocrit assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000232 ] ] . obo:OBI_2100165 obo:IAO_0000111 "venous blood creatinine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatinine in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood creatinine assay" ; rdfs:subClassOf obo:OBI_2100003, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] . obo:OBI_2100166 obo:IAO_0000111 "blood gas venous blood oxygen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of oxygen in venous blood as part of a blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "blood gas venous blood oxygen assay" ; rdfs:subClassOf obo:OBI_2100036, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] . obo:OBI_2100167 obo:IAO_0000111 "ionized venous blood ionized calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of ionized calcium in venous blood as part of a ionized order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ionized venous blood ionized calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100168 obo:IAO_0000111 "blood gas venous blood carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "blood gas venous blood carbon dioxide assay" ; rdfs:subClassOf obo:OBI_2100001, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:OBI_2100169 obo:IAO_0000111 "blood gas venous blood bicarbonate assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bicarbonate in venous blood as part of a blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "blood gas venous blood bicarbonate assay" ; rdfs:subClassOf obo:OBI_2100043, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] . obo:OBI_2100170 obo:IAO_0000111 "arterial blood creatinine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatinine in arterial blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "arterial blood creatinine assay" ; rdfs:subClassOf obo:OBI_2100003, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] . obo:OBI_2100171 obo:IAO_0000111 "venous blood tacrolimus assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of tacrolimus in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood tacrolimus assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_61057 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_61057 ] ) ] . obo:OBI_2100172 obo:IAO_0000111 "random venous blood vancomycin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of vancomycin in venous blood as part of a random order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "random venous blood vancomycin assay" ; rdfs:subClassOf obo:OBI_2100044, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_28001 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_28001 ] ) ] . obo:OBI_2100173 obo:IAO_0000111 "venous blood mycophenolic acid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of mycophenolic acid in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood mycophenolic acid assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_168396 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_168396 ] ) ] . obo:OBI_2100174 obo:IAO_0000111 "non-vented blood gas arterial blood carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide in arterial blood as part of a non-vented blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "non-vented blood gas arterial blood carbon dioxide assay" ; rdfs:subClassOf obo:OBI_2100001, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:OBI_2100175 obo:IAO_0000111 "non-vented blood gas arterial blood oxygen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of oxygen in arterial blood as part of a non-vented blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "non-vented blood gas arterial blood oxygen assay" ; rdfs:subClassOf obo:OBI_2100036, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] . obo:OBI_2100176 obo:IAO_0000111 "non-vented blood gas arterial blood bicarbonate assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bicarbonate in arterial blood as part of a non-vented blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "non-vented blood gas arterial blood bicarbonate assay" ; rdfs:subClassOf obo:OBI_2100043, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] . obo:OBI_2100177 obo:IAO_0000111 "quantitative venous blood IgG assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures IgG in venous blood as part of a quantitative order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "quantitative venous blood IgG assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0071735 ] ] . obo:OBI_2100178 obo:IAO_0000111 "quantitative venous blood IgM assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures IgM in venous blood as part of a quantitative order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "quantitative venous blood IgM assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0071753 ] ] . obo:OBI_2100179 obo:IAO_0000111 "quantitative venous blood IgA assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures IgA in venous blood as part of a quantitative order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "quantitative venous blood IgA assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0071745 ] ] . obo:OBI_2100180 obo:IAO_0000111 "arterial blood sodium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium in arterial blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "arterial blood sodium assay" ; rdfs:subClassOf obo:OBI_2100002, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] . obo:OBI_2100181 obo:IAO_0000111 "arterial blood potassium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of potassium in arterial blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "arterial blood potassium assay" ; rdfs:subClassOf obo:OBI_2100004, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] . obo:OBI_2100182 obo:IAO_0000111 "ionized arterial blood calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of calcium in arterial blood as part of a ionized order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ionized arterial blood calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100183 obo:IAO_0000111 "vented blood gas arterial blood bicarbonate assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bicarbonate in arterial blood as part of a vented blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "vented blood gas arterial blood bicarbonate assay" ; rdfs:subClassOf obo:OBI_2100043, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] . obo:OBI_2100184 obo:IAO_0000111 "vented blood gas arterial blood oxygen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of oxygen in arterial blood as part of a vented blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "vented blood gas arterial blood oxygen assay" ; rdfs:subClassOf obo:OBI_2100036, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] . obo:OBI_2100185 obo:IAO_0000111 "vented blood gas arterial blood carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide in arterial blood as part of a vented blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "vented blood gas arterial blood carbon dioxide assay" ; rdfs:subClassOf obo:OBI_2100001, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:OBI_2100186 obo:IAO_0000111 "arterial blood hematocrit assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the proportion of red blood cells in arterial blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "arterial blood hematocrit assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000232 ] ] . obo:OBI_2100187 obo:IAO_0000111 "arterial blood chloride assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of chloride in arterial blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "arterial blood chloride assay" ; rdfs:subClassOf obo:OBI_2100010, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] . obo:OBI_2100188 obo:IAO_0000111 "arterial blood hemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of hemoglobin in arterial blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "arterial blood hemoglobin assay" ; rdfs:subClassOf obo:OBI_2100014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] . obo:OBI_2100189 obo:IAO_0000111 "GEM premier blood gas venous blood hematocrit assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the proportion of red blood cells in venous blood as part of a GEM premier blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM premier blood gas venous blood hematocrit assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000232 ] ] . obo:OBI_2100190 obo:IAO_0000111 "GEM premier blood gas venous blood ionized calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of ionized calcium in venous blood as part of a GEM premier blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM premier blood gas venous blood ionized calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100191 obo:IAO_0000111 "GEM premier blood gas venous blood potassium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of potassium in venous blood as part of a GEM premier blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM premier blood gas venous blood potassium assay" ; rdfs:subClassOf obo:OBI_2100004, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] . obo:OBI_2100192 obo:IAO_0000111 "GEM premier blood gas venous blood oxygen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of oxygen in venous blood as part of a GEM premier blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM premier blood gas venous blood oxygen assay" ; rdfs:subClassOf obo:OBI_2100036, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] . obo:OBI_2100193 obo:IAO_0000111 "GEM premier blood gas venous blood hemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of hemoglobin in venous blood as part of a GEM premier blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM premier blood gas venous blood hemoglobin assay" ; rdfs:subClassOf obo:OBI_2100014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] . obo:OBI_2100194 obo:IAO_0000111 "GEM premier blood gas venous blood bicarbonate assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bicarbonate in venous blood as part of a GEM premier blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM premier blood gas venous blood bicarbonate assay" ; rdfs:subClassOf obo:OBI_2100043, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] . obo:OBI_2100195 obo:IAO_0000111 "GEM premier blood gas venous blood glucose assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of glucose in venous blood as part of a GEM premier blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM premier blood gas venous blood glucose assay" ; rdfs:subClassOf obo:OBI_2100020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] . obo:OBI_2100196 obo:IAO_0000111 "GEM premier blood gas venous blood sodium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium in venous blood as part of a GEM premier blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM premier blood gas venous blood sodium assay" ; rdfs:subClassOf obo:OBI_2100002, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] . obo:OBI_2100197 obo:IAO_0000111 "GEM premier blood gas venous blood lactic acid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures lactic acid in venous blood as part of a GEM premier blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM premier blood gas venous blood lactic acid assay" ; rdfs:subClassOf obo:OBI_2100042, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CHEBI_28358 ] ] . obo:OBI_2100198 obo:IAO_0000111 "GEM premier blood gas venous blood carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a GEM premier blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM premier blood gas venous blood carbon dioxide assay" ; rdfs:subClassOf obo:OBI_2100001, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:OBI_2100199 obo:IAO_0000111 "trough venous blood tobramycin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of tobramycin in venous blood as part of a trough order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "trough venous blood tobramycin assay" ; rdfs:subClassOf obo:OBI_2100045, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_28864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_28864 ] ) ] . obo:OBI_2100200 obo:IAO_0000111 "random venous blood tobramycin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of tobramycin in venous blood as part of a random order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "random venous blood tobramycin assay" ; rdfs:subClassOf obo:OBI_2100045, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_28864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_28864 ] ) ] . obo:OBI_2100201 obo:IAO_0000111 "CBC with manual differential venous blood metamyelocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of metamyelocytes in venous blood as part of a CBC with manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with manual differential venous blood metamyelocyte count assay" ; rdfs:subClassOf obo:OBI_0003017, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0002192 ] ] . obo:OBI_2100202 obo:IAO_0000111 "arterial blood lactic acid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures lactic acid in arterial blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "arterial blood lactic acid assay" ; rdfs:subClassOf obo:OBI_2100042, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CHEBI_28358 ] ] . obo:OBI_2100203 obo:IAO_0000111 "venous blood 25-hydroxyvitamin D2 assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of 25-hydroxyvitamin D2 in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood 25-hydroxyvitamin D2 assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_86319 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_86319 ] ) ] . obo:OBI_2100204 obo:IAO_0000111 "venous blood digoxin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of digoxin in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood digoxin assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_4551 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_4551 ] ) ] . obo:OBI_2100205 obo:IAO_0000111 "urine protein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of protein in urine" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "urine protein assay" ; rdfs:subClassOf obo:OBI_0003043, obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000651 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000651 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000000001 ] ) ] . obo:OBI_2100206 obo:IAO_0000111 "venous blood tobramycin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of tobramycin in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood tobramycin assay" ; rdfs:subClassOf obo:OBI_2100045, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_28864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_28864 ] ) ] . obo:OBI_2100207 obo:IAO_0000111 "CBC with manual differential venous blood myelocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of myelocytes in venous blood as part of a CBC with manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with manual differential venous blood myelocyte count assay" ; rdfs:subClassOf obo:OBI_0003165, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0002193 ] ] . obo:OBI_2100208 obo:IAO_0000111 "SPEP protein electrophoresis venous blood beta-globin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of beta-globin in venous blood as part of a SPEP protein electrophoresis order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "SPEP protein electrophoresis venous blood beta-globin assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000008457 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000008457 ] ) ] . obo:OBI_2100209 obo:IAO_0000111 "SPEP protein electrophoresis venous blood albumin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of albumin in venous blood as part of a SPEP protein electrophoresis order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "SPEP protein electrophoresis venous blood albumin assay" ; rdfs:subClassOf obo:OBI_2100022, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003918 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003918 ] ) ] . obo:OBI_2100210 obo:IAO_0000111 "SPEP protein electrophoresis venous blood protein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of protein in venous blood as part of a SPEP protein electrophoresis order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "SPEP protein electrophoresis venous blood protein assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000000001 ] ) ] . obo:OBI_2100211 obo:IAO_0000111 "trough venous blood vancomycin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of vancomycin in venous blood as part of a trough order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "trough venous blood vancomycin assay" ; rdfs:subClassOf obo:OBI_2100044, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_28001 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_28001 ] ) ] . obo:OBI_2100212 obo:IAO_0000111 "hepatic panel venous blood protein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of protein in venous blood as part of a hepatic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "hepatic panel venous blood protein assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000000001 ] ) ] . obo:OBI_2100213 obo:IAO_0000111 "hepatic panel venous blood bilirubin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bilirubin in venous blood as part of a hepatic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "hepatic panel venous blood bilirubin assay" ; rdfs:subClassOf obo:OBI_2100018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16990 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16990 ] ) ] . obo:OBI_2100214 obo:IAO_0000111 "hepatic panel venous blood alanine aminotransferase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of alanine aminotransferase in venous blood as part of a hepatic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "hepatic panel venous blood alanine aminotransferase assay" ; rdfs:subClassOf obo:OBI_2100016, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050219 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050219 ] ) ] . obo:OBI_2100215 obo:IAO_0000111 "hepatic panel venous blood human aspartate aminotransferase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of human aspartate aminotransferase in venous blood as part of a hepatic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "hepatic panel venous blood human aspartate aminotransferase assay" ; rdfs:subClassOf obo:OBI_2100019, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050353 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050353 ] ) ] . obo:OBI_2100216 obo:IAO_0000111 "hepatic panel venous blood albumin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of albumin in venous blood as part of a hepatic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "hepatic panel venous blood albumin assay" ; rdfs:subClassOf obo:OBI_2100022, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003918 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003918 ] ) ] . obo:OBI_2100217 obo:IAO_0000111 "hepatic panel venous blood human alkaline phosphatase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of human alkaline phosphatase in venous blood as part of a hepatic panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "hepatic panel venous blood human alkaline phosphatase assay" ; rdfs:subClassOf obo:OBI_2100017, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050343 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050343 ] ) ] . obo:OBI_2100218 obo:IAO_0000111 "estimated venous blood glomerular filtration assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures glomerular filtration in venous blood as part of a estimated order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "estimated venous blood glomerular filtration assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0003094 ] ] . obo:OBI_2100219 obo:IAO_0000111 "DT60 venous blood creatinine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatinine in venous blood as part of a DT60 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "DT60 venous blood creatinine assay" ; rdfs:subClassOf obo:OBI_2100003, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] . obo:OBI_2100220 obo:IAO_0000111 "fasting venous blood glucose assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of glucose in venous blood as part of a fasting order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "fasting venous blood glucose assay" ; rdfs:subClassOf obo:OBI_2100020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] . obo:OBI_2100221 obo:IAO_0000111 "random venous blood amikacin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of amikacin in venous blood as part of a random order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "random venous blood amikacin assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_2637 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_2637 ] ) ] . obo:OBI_2100222 obo:IAO_0000111 "venous blood ammonia assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of ammonia in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood ammonia assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16134 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16134 ] ) ] . obo:OBI_2100223 obo:IAO_0000111 "venous blood GGT assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of GGT in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood GGT assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000029983 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000029983 ] ) ] . obo:OBI_2100224 obo:IAO_0000111 "chem11 venous blood phosphate assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of phosphate in venous blood as part of a chem11 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem11 venous blood phosphate assay" ; rdfs:subClassOf obo:OBI_2100015, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35780 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35780 ] ) ] . obo:OBI_2100225 obo:IAO_0000111 "chem11 venous blood potassium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of potassium in venous blood as part of a chem11 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem11 venous blood potassium assay" ; rdfs:subClassOf obo:OBI_2100004, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] . obo:OBI_2100226 obo:IAO_0000111 "chem11 venous blood calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of calcium in venous blood as part of a chem11 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem11 venous blood calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100227 obo:IAO_0000111 "chem11 venous blood glucose assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of glucose in venous blood as part of a chem11 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem11 venous blood glucose assay" ; rdfs:subClassOf obo:OBI_2100020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] . obo:OBI_2100228 obo:IAO_0000111 "chem11 venous blood carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a chem11 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem11 venous blood carbon dioxide assay" ; rdfs:subClassOf obo:OBI_2100001, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:OBI_2100229 obo:IAO_0000111 "chem11 venous blood albumin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of albumin in venous blood as part of a chem11 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem11 venous blood albumin assay" ; rdfs:subClassOf obo:OBI_2100022, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003918 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003918 ] ) ] . obo:OBI_2100230 obo:IAO_0000111 "chem11 venous blood sodium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium in venous blood as part of a chem11 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem11 venous blood sodium assay" ; rdfs:subClassOf obo:OBI_2100002, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] . obo:OBI_2100231 obo:IAO_0000111 "chem11 venous blood magnesium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of magnesium in venous blood as part of a chem11 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem11 venous blood magnesium assay" ; rdfs:subClassOf obo:OBI_2100021, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39127 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39127 ] ) ] . obo:OBI_2100232 obo:IAO_0000111 "chem11 venous blood creatinine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatinine in venous blood as part of a chem11 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem11 venous blood creatinine assay" ; rdfs:subClassOf obo:OBI_2100003, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] . obo:OBI_2100233 obo:IAO_0000111 "chem11 venous blood chloride assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of chloride in venous blood as part of a chem11 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem11 venous blood chloride assay" ; rdfs:subClassOf obo:OBI_2100010, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] . obo:OBI_2100234 obo:IAO_0000111 "total venous blood IgE assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures IgE in venous blood as part of a total order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "total venous blood IgE assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:GO_0071742 ] ] . obo:OBI_2100235 obo:IAO_0000111 "chem16 venous blood human aspartate aminotransferase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of human aspartate aminotransferase in venous blood as part of a chem16 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem16 venous blood human aspartate aminotransferase assay" ; rdfs:subClassOf obo:OBI_2100019, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050353 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050353 ] ) ] . obo:OBI_2100236 obo:IAO_0000111 "chem16 venous blood creatinine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatinine in venous blood as part of a chem16 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem16 venous blood creatinine assay" ; rdfs:subClassOf obo:OBI_2100003, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] . obo:OBI_2100237 obo:IAO_0000111 "chem16 venous blood magnesium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of magnesium in venous blood as part of a chem16 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem16 venous blood magnesium assay" ; rdfs:subClassOf obo:OBI_2100021, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39127 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39127 ] ) ] . obo:OBI_2100238 obo:IAO_0000111 "chem16 venous blood carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a chem16 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem16 venous blood carbon dioxide assay" ; rdfs:subClassOf obo:OBI_2100001, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:OBI_2100239 obo:IAO_0000111 "chem16 venous blood glucose assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of glucose in venous blood as part of a chem16 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem16 venous blood glucose assay" ; rdfs:subClassOf obo:OBI_2100020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] . obo:OBI_2100240 obo:IAO_0000111 "chem16 venous blood calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of calcium in venous blood as part of a chem16 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem16 venous blood calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100241 obo:IAO_0000111 "chem16 venous blood triglyceride assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of triglyceride in venous blood as part of a chem16 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem16 venous blood triglyceride assay" ; rdfs:subClassOf obo:OBI_2100029, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17855 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17855 ] ) ] . obo:OBI_2100242 obo:IAO_0000111 "chem16 venous blood sodium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium in venous blood as part of a chem16 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem16 venous blood sodium assay" ; rdfs:subClassOf obo:OBI_2100002, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] . obo:OBI_2100243 obo:IAO_0000111 "chem16 venous blood phosphate assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of phosphate in venous blood as part of a chem16 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem16 venous blood phosphate assay" ; rdfs:subClassOf obo:OBI_2100015, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35780 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35780 ] ) ] . obo:OBI_2100244 obo:IAO_0000111 "chem16 venous blood human alkaline phosphatase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of human alkaline phosphatase in venous blood as part of a chem16 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem16 venous blood human alkaline phosphatase assay" ; rdfs:subClassOf obo:OBI_2100017, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050343 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050343 ] ) ] . obo:OBI_2100245 obo:IAO_0000111 "chem16 venous blood albumin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of albumin in venous blood as part of a chem16 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem16 venous blood albumin assay" ; rdfs:subClassOf obo:OBI_2100022, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003918 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003918 ] ) ] . obo:OBI_2100246 obo:IAO_0000111 "chem16 venous blood bilirubin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bilirubin in venous blood as part of a chem16 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem16 venous blood bilirubin assay" ; rdfs:subClassOf obo:OBI_2100018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16990 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16990 ] ) ] . obo:OBI_2100247 obo:IAO_0000111 "chem16 venous blood chloride assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of chloride in venous blood as part of a chem16 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem16 venous blood chloride assay" ; rdfs:subClassOf obo:OBI_2100010, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] . obo:OBI_2100248 obo:IAO_0000111 "chem16 venous blood alanine aminotransferase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of alanine aminotransferase in venous blood as part of a chem16 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem16 venous blood alanine aminotransferase assay" ; rdfs:subClassOf obo:OBI_2100016, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050219 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050219 ] ) ] . obo:OBI_2100249 obo:IAO_0000111 "chem16 venous blood potassium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of potassium in venous blood as part of a chem16 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "chem16 venous blood potassium assay" ; rdfs:subClassOf obo:OBI_2100004, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] . obo:OBI_2100250 obo:IAO_0000111 "POC chem8 arterial blood glucose assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of glucose in arterial blood as part of a POC chem8 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "POC chem8 arterial blood glucose assay" ; rdfs:subClassOf obo:OBI_2100020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] . obo:OBI_2100251 obo:IAO_0000111 "POC chem8 arterial blood ionized calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of ionized calcium in arterial blood as part of a POC chem8 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "POC chem8 arterial blood ionized calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100252 obo:IAO_0000111 "POC chem8 arterial blood potassium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of potassium in arterial blood as part of a POC chem8 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "POC chem8 arterial blood potassium assay" ; rdfs:subClassOf obo:OBI_2100004, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] . obo:OBI_2100253 obo:IAO_0000111 "POC chem8 arterial blood sodium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium in arterial blood as part of a POC chem8 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "POC chem8 arterial blood sodium assay" ; rdfs:subClassOf obo:OBI_2100002, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] . obo:OBI_2100254 obo:IAO_0000111 "POC chem8 arterial blood creatinine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatinine in arterial blood as part of a POC chem8 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "POC chem8 arterial blood creatinine assay" ; rdfs:subClassOf obo:OBI_2100003, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] . obo:OBI_2100255 obo:IAO_0000111 "POC chem8 arterial blood hematocrit assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the proportion of red blood cells in arterial blood as part of a POC chem8 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "POC chem8 arterial blood hematocrit assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000232 ] ] . obo:OBI_2100256 obo:IAO_0000111 "POC chem8 arterial blood chloride assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of chloride in arterial blood as part of a POC chem8 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "POC chem8 arterial blood chloride assay" ; rdfs:subClassOf obo:OBI_2100010, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] . obo:OBI_2100257 obo:IAO_0000111 "peak venous blood tobramycin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of tobramycin in venous blood as part of a peak order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "peak venous blood tobramycin assay" ; rdfs:subClassOf obo:OBI_2100045, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_28864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_28864 ] ) ] . obo:OBI_2100258 obo:IAO_0000111 "24 hour urine creatinine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatinine in urine as part of a 24 hour order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "24 hour urine creatinine assay" ; rdfs:subClassOf obo:OBI_0003043, obo:OBI_2100003, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000651 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000651 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] . obo:OBI_2100259 obo:IAO_0000111 "intact venous blood PTH assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of PTH in venous blood as part of a intact order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "intact venous blood PTH assay" ; rdfs:subClassOf obo:OBI_2100034, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003015 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003015 ] ) ] . obo:OBI_2100260 obo:IAO_0000111 "total venous blood PSA assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of PSA in venous blood as part of a total order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "total venous blood PSA assay" ; rdfs:subClassOf obo:OBI_2100034, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003015 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003015 ] ) ] . obo:OBI_2100261 obo:IAO_0000111 "total venous blood T3 assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of T3 in venous blood as part of a total order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "total venous blood T3 assay" ; rdfs:subClassOf obo:OBI_2100046, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_28774 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_28774 ] ) ] . obo:OBI_2100262 obo:IAO_0000111 "24 hour urine protein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of protein in urine as part of a 24 hour order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "24 hour urine protein assay" ; rdfs:subClassOf obo:OBI_0003043, obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000651 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000651 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000000001 ] ) ] . obo:OBI_2100263 obo:IAO_0000111 "total venous blood cholesterol assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of cholesterol in venous blood as part of a total order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "total venous blood cholesterol assay" ; rdfs:subClassOf obo:OBI_2100031, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16113 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16113 ] ) ] . obo:OBI_2100264 obo:IAO_0000111 "venous blood triglyceride assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of triglyceride in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood triglyceride assay" ; rdfs:subClassOf obo:OBI_2100029, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17855 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17855 ] ) ] . obo:OBI_2100265 obo:IAO_0000111 "tube 4 count cerebrospinal fluid cell count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of cells in cerebrospinal fluid as part of a tube 4 count order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "tube 4 count cerebrospinal fluid cell count assay" ; rdfs:subClassOf obo:OBI_0001977, obo:OBI_0003232, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002502 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002502 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000000 ] ] . obo:OBI_2100266 obo:IAO_0000111 "cerebrospinal fluid protein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of protein in cerebrospinal fluid" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "cerebrospinal fluid protein assay" ; rdfs:subClassOf obo:OBI_0003232, obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002502 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002502 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000000001 ] ) ] . obo:OBI_2100267 obo:IAO_0000111 "cerebrospinal fluid glucose assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of glucose in cerebrospinal fluid" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "cerebrospinal fluid glucose assay" ; rdfs:subClassOf obo:OBI_0003232, obo:OBI_2100020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002502 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002502 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] . obo:OBI_2100268 obo:IAO_0000111 "tube 1 count cerebrospinal fluid cell count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of cells in cerebrospinal fluid as part of a tube 1 count order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "tube 1 count cerebrospinal fluid cell count assay" ; rdfs:subClassOf obo:OBI_0001977, obo:OBI_0003232, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002502 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002502 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000000 ] ] . obo:OBI_2100269 obo:IAO_0000111 "venous blood dehydroepiandrosterone assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of dehydroepiandrosterone in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood dehydroepiandrosterone assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_28689 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_28689 ] ) ] . obo:OBI_2100270 obo:IAO_0000111 "venous blood cortisol assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of cortisol in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood cortisol assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17650 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17650 ] ) ] . obo:OBI_2100271 obo:IAO_0000111 "ABL90 panel arterial blood sodium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium in arterial blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel arterial blood sodium assay" ; rdfs:subClassOf obo:OBI_2100002, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] . obo:OBI_2100272 obo:IAO_0000111 "ABL90 panel arterial blood oxygen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of oxygen in arterial blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel arterial blood oxygen assay" ; rdfs:subClassOf obo:OBI_2100036, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] . obo:OBI_2100273 obo:IAO_0000111 "ABL90 panel arterial blood glucose assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of glucose in arterial blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel arterial blood glucose assay" ; rdfs:subClassOf obo:OBI_2100020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] . obo:OBI_2100274 obo:IAO_0000111 "ABL90 panel arterial blood lactic acid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures lactic acid in arterial blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel arterial blood lactic acid assay" ; rdfs:subClassOf obo:OBI_2100042, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CHEBI_28358 ] ] . obo:OBI_2100275 obo:IAO_0000111 "ABL90 panel arterial blood hemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of hemoglobin in arterial blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel arterial blood hemoglobin assay" ; rdfs:subClassOf obo:OBI_2100014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] . obo:OBI_2100276 obo:IAO_0000111 "ABL90 panel arterial blood chloride assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of chloride in arterial blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel arterial blood chloride assay" ; rdfs:subClassOf obo:OBI_2100010, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] . obo:OBI_2100277 obo:IAO_0000111 "ABL90 panel arterial blood carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide in arterial blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel arterial blood carbon dioxide assay" ; rdfs:subClassOf obo:OBI_2100001, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:OBI_2100278 obo:IAO_0000111 "ABL90 panel arterial blood hematocrit assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the proportion of red blood cells in arterial blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel arterial blood hematocrit assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000232 ] ] . obo:OBI_2100279 obo:IAO_0000111 "ABL90 panel arterial blood calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of calcium in arterial blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel arterial blood calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100280 obo:IAO_0000111 "ABL90 panel arterial blood temperature assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures temperature in arterial blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel arterial blood temperature assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PATO_0000146 ] ] . obo:OBI_2100281 obo:IAO_0000111 "ABL90 panel arterial blood bicarbonate assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bicarbonate in arterial blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel arterial blood bicarbonate assay" ; rdfs:subClassOf obo:OBI_2100043, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] . obo:OBI_2100282 obo:IAO_0000111 "ABL90 panel arterial blood potassium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of potassium in arterial blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel arterial blood potassium assay" ; rdfs:subClassOf obo:OBI_2100004, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] . obo:OBI_2100283 obo:IAO_0000111 "CBC with manual differential venous blood promyelocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of promyelocytes in venous blood as part of a CBC with manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with manual differential venous blood promyelocyte count assay" ; rdfs:subClassOf obo:OBI_0003019, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000836 ] ] . obo:OBI_2100284 obo:IAO_0000111 "ABL90 panel venous blood glucose assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of glucose in venous blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel venous blood glucose assay" ; rdfs:subClassOf obo:OBI_2100020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] . obo:OBI_2100285 obo:IAO_0000111 "ABL90 panel venous blood hemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of hemoglobin in venous blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel venous blood hemoglobin assay" ; rdfs:subClassOf obo:OBI_2100014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] . obo:OBI_2100286 obo:IAO_0000111 "ABL90 panel venous blood ionized calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of ionized calcium in venous blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel venous blood ionized calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100287 obo:IAO_0000111 "ABL90 panel venous blood carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel venous blood carbon dioxide assay" ; rdfs:subClassOf obo:OBI_2100001, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:OBI_2100288 obo:IAO_0000111 "ABL90 panel venous blood hematocrit assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the proportion of red blood cells in venous blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel venous blood hematocrit assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000232 ] ] . obo:OBI_2100289 obo:IAO_0000111 "ABL90 panel venous blood sodium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium in venous blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel venous blood sodium assay" ; rdfs:subClassOf obo:OBI_2100002, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] . obo:OBI_2100290 obo:IAO_0000111 "ABL90 panel venous blood oxygen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of oxygen in venous blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel venous blood oxygen assay" ; rdfs:subClassOf obo:OBI_2100036, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] . obo:OBI_2100291 obo:IAO_0000111 "ABL90 panel venous blood bicarbonate assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bicarbonate in venous blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel venous blood bicarbonate assay" ; rdfs:subClassOf obo:OBI_2100043, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] . obo:OBI_2100292 obo:IAO_0000111 "ABL90 panel venous blood lactic acid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures lactic acid in venous blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel venous blood lactic acid assay" ; rdfs:subClassOf obo:OBI_2100042, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CHEBI_28358 ] ] . obo:OBI_2100293 obo:IAO_0000111 "ABL90 panel venous blood chloride assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of chloride in venous blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel venous blood chloride assay" ; rdfs:subClassOf obo:OBI_2100010, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17996 ] ) ] . obo:OBI_2100294 obo:IAO_0000111 "venous blood T4 assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of T4 in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood T4 assay" ; rdfs:subClassOf obo:OBI_2100035, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_30660 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_30660 ] ) ] . obo:OBI_2100295 obo:IAO_0000111 "free venous blood T4 assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of T4 in venous blood as part of a free order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "free venous blood T4 assay" ; rdfs:subClassOf obo:OBI_2100035, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_30660 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_30660 ] ) ] . obo:OBI_2100296 obo:IAO_0000111 "ABL90 panel venous blood potassium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of potassium in venous blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel venous blood potassium assay" ; rdfs:subClassOf obo:OBI_2100004, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] . obo:OBI_2100297 obo:IAO_0000111 "urine sodium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium in urine" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "urine sodium assay" ; rdfs:subClassOf obo:OBI_0003043, obo:OBI_2100002, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000651 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000651 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] . obo:OBI_2100298 obo:IAO_0000111 "bone profile venous blood albumin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of albumin in venous blood as part of a bone profile order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "bone profile venous blood albumin assay" ; rdfs:subClassOf obo:OBI_2100022, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003918 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003918 ] ) ] . obo:OBI_2100299 obo:IAO_0000111 "bone profile venous blood calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of calcium in venous blood as part of a bone profile order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "bone profile venous blood calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100300 obo:IAO_0000111 "bone profile venous blood human alkaline phosphatase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of human alkaline phosphatase in venous blood as part of a bone profile order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "bone profile venous blood human alkaline phosphatase assay" ; rdfs:subClassOf obo:OBI_2100017, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050343 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050343 ] ) ] . obo:OBI_2100301 obo:IAO_0000111 "bone profile venous blood protein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of protein in venous blood as part of a bone profile order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "bone profile venous blood protein assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000000001 ] ) ] . obo:OBI_2100302 obo:IAO_0000111 "bone profile venous blood phosphate assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of phosphate in venous blood as part of a bone profile order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "bone profile venous blood phosphate assay" ; rdfs:subClassOf obo:OBI_2100015, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35780 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35780 ] ) ] . obo:OBI_2100303 obo:IAO_0000111 "ABG/electrolytes arterial blood carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide in arterial blood as part of a ABG/electrolytes order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABG/electrolytes arterial blood carbon dioxide assay" ; rdfs:subClassOf obo:OBI_2100001, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:OBI_2100304 obo:IAO_0000111 "ABG/electrolytes arterial blood oxygen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of oxygen in arterial blood as part of a ABG/electrolytes order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABG/electrolytes arterial blood oxygen assay" ; rdfs:subClassOf obo:OBI_2100036, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] . obo:OBI_2100305 obo:IAO_0000111 "ABG/electrolytes arterial blood ionized calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of ionized calcium in arterial blood as part of a ABG/electrolytes order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABG/electrolytes arterial blood ionized calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100306 obo:IAO_0000111 "CBC with automated differential venous blood nucleated RBC count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of nucleated RBCs in venous blood as part of a CBC with automated differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with automated differential venous blood nucleated RBC count assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000562 ] ] . obo:OBI_2100307 obo:IAO_0000111 "ABL90 panel venous blood methemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of methemoglobin in venous blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel venous blood methemoglobin assay" ; rdfs:subClassOf obo:OBI_2100040, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17423 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17423 ] ) ] . obo:OBI_2100308 obo:IAO_0000111 "ABL90 panel arterial blood methemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of methemoglobin in arterial blood as part of a ABL90 panel order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ABL90 panel arterial blood methemoglobin assay" ; rdfs:subClassOf obo:OBI_2100040, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17423 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17423 ] ) ] . obo:OBI_2100309 obo:IAO_0000111 "venous blood valproic acid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of valproic acid in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood valproic acid assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39867 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39867 ] ) ] . obo:OBI_2100310 obo:IAO_0000111 "high sensitivity cardiac/neonatal venous blood c-reactive protein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of c-reactive protein in venous blood as part of a high sensitivity cardiac/neonatal order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "high sensitivity cardiac/neonatal venous blood c-reactive protein assay" ; rdfs:subClassOf obo:OBI_2100047, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000005897 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000005897 ] ) ] . obo:OBI_2100311 obo:IAO_0000111 "POC arterial blood creatinine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatinine in arterial blood as part of a POC order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "POC arterial blood creatinine assay" ; rdfs:subClassOf obo:OBI_2100003, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] . obo:OBI_2100312 obo:IAO_0000111 "GEM4000 ANLCOOX arterial blood bicarbonate assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bicarbonate in arterial blood as part of a GEM4000 ANLCOOX order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4000 ANLCOOX arterial blood bicarbonate assay" ; rdfs:subClassOf obo:OBI_2100043, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] . obo:OBI_2100313 obo:IAO_0000111 "GEM4000 ANLCOOX arterial blood oxygen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of oxygen in arterial blood as part of a GEM4000 ANLCOOX order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4000 ANLCOOX arterial blood oxygen assay" ; rdfs:subClassOf obo:OBI_2100036, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] . obo:OBI_2100314 obo:IAO_0000111 "GEM4000 ANLCOOX arterial blood hematocrit assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the proportion of red blood cells in arterial blood as part of a GEM4000 ANLCOOX order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4000 ANLCOOX arterial blood hematocrit assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000232 ] ] . obo:OBI_2100315 obo:IAO_0000111 "GEM4000 ANLCOOX arterial blood temperature assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures temperature in arterial blood as part of a GEM4000 ANLCOOX order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4000 ANLCOOX arterial blood temperature assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PATO_0000146 ] ] . obo:OBI_2100316 obo:IAO_0000111 "GEM4000 ANLCOOX arterial blood hemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of hemoglobin in arterial blood as part of a GEM4000 ANLCOOX order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4000 ANLCOOX arterial blood hemoglobin assay" ; rdfs:subClassOf obo:OBI_2100014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] . obo:OBI_2100317 obo:IAO_0000111 "GEM4000 ANLCOOX arterial blood potassium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of potassium in arterial blood as part of a GEM4000 ANLCOOX order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4000 ANLCOOX arterial blood potassium assay" ; rdfs:subClassOf obo:OBI_2100004, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] . obo:OBI_2100318 obo:IAO_0000111 "GEM4000 ANLCOOX arterial blood glucose assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of glucose in arterial blood as part of a GEM4000 ANLCOOX order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4000 ANLCOOX arterial blood glucose assay" ; rdfs:subClassOf obo:OBI_2100020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] . obo:OBI_2100319 obo:IAO_0000111 "GEM4000 ANLCOOX arterial blood ionized calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of ionized calcium in arterial blood as part of a GEM4000 ANLCOOX order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4000 ANLCOOX arterial blood ionized calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100320 obo:IAO_0000111 "GEM4000 ANLCOOX arterial blood carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide in arterial blood as part of a GEM4000 ANLCOOX order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4000 ANLCOOX arterial blood carbon dioxide assay" ; rdfs:subClassOf obo:OBI_2100001, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:OBI_2100321 obo:IAO_0000111 "GEM4000 ANLCOOX arterial blood sodium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium in arterial blood as part of a GEM4000 ANLCOOX order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4000 ANLCOOX arterial blood sodium assay" ; rdfs:subClassOf obo:OBI_2100002, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] . obo:OBI_2100322 obo:IAO_0000111 "ionized venous blood calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of calcium in venous blood as part of a ionized order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "ionized venous blood calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100323 obo:IAO_0000111 "venous blood hemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of hemoglobin in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood hemoglobin assay" ; rdfs:subClassOf obo:OBI_2100014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] . obo:OBI_2100324 obo:IAO_0000111 "CBC with manual differential venous blood megakaryocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of megakaryocytes in venous blood as part of a CBC with manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with manual differential venous blood megakaryocyte count assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000556 ] ] . obo:OBI_2100325 obo:IAO_0000111 "non-cardiac venous blood c-reactive protein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of c-reactive protein in venous blood as part of a non-cardiac order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "non-cardiac venous blood c-reactive protein assay" ; rdfs:subClassOf obo:OBI_2100047, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000005897 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000005897 ] ) ] . obo:OBI_2100326 obo:IAO_0000111 "intraoperative venous blood PTH assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of PTH in venous blood as part of a intraoperative order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "intraoperative venous blood PTH assay" ; rdfs:subClassOf obo:OBI_2100034, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003015 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003015 ] ) ] . obo:OBI_2100327 obo:IAO_0000111 "venous blood parathyroid hormone assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of parathyroid hormone in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood parathyroid hormone assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000013429 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000013429 ] ) ] . obo:OBI_2100328 obo:IAO_0000111 "total bodily fluid protein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of protein in bodily fluid as part of a total order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "total bodily fluid protein assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000009 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000009 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000000001 ] ) ] . obo:OBI_2100329 obo:IAO_0000111 "bodily fluid glucose assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of glucose in bodily fluid" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "bodily fluid glucose assay" ; rdfs:subClassOf obo:OBI_2100020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000009 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000009 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] . obo:OBI_2100330 obo:IAO_0000111 "count bodily fluid cell count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of cells in bodily fluid as part of a count order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "count bodily fluid cell count assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000009 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000009 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000000 ] ] . obo:OBI_2100331 obo:IAO_0000111 "manual differential bodily fluid segmented neutrophil count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of segmented neutrophils in bodily fluid as part of a manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "manual differential bodily fluid segmented neutrophil count assay" ; rdfs:subClassOf obo:OBI_0003022, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000009 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000009 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0011114 ] ] . obo:OBI_2100332 obo:IAO_0000111 "manual differential bodily fluid mesothelial cell count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of mesothelial cells in bodily fluid as part of a manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "manual differential bodily fluid mesothelial cell count assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000009 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000009 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000077 ] ] . obo:OBI_2100333 obo:IAO_0000111 "manual differential bodily fluid monocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of monocytes in bodily fluid as part of a manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "manual differential bodily fluid monocyte count assay" ; rdfs:subClassOf obo:OBI_0003025, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000009 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000009 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000576 ] ] . obo:OBI_2100334 obo:IAO_0000111 "manual differential bodily fluid lymphocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of lymphocytes in bodily fluid as part of a manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "manual differential bodily fluid lymphocyte count assay" ; rdfs:subClassOf obo:OBI_0003024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000009 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000009 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000542 ] ] . obo:OBI_2100335 obo:IAO_0000111 "manual differential bodily fluid macrophage count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of macrophages in bodily fluid as part of a manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "manual differential bodily fluid macrophage count assay" ; rdfs:subClassOf obo:OBI_0003027, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000009 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000009 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000235 ] ] . obo:OBI_2100336 obo:IAO_0000111 "manual differential bodily fluid basophil count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of basophils in bodily fluid as part of a manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "manual differential bodily fluid basophil count assay" ; rdfs:subClassOf obo:OBI_0003021, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000009 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000009 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000767 ] ] . obo:OBI_2100337 obo:IAO_0000111 "manual differential bodily fluid eosinophil count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of eosinophils in bodily fluid as part of a manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "manual differential bodily fluid eosinophil count assay" ; rdfs:subClassOf obo:OBI_0003023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000009 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000009 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000771 ] ] . obo:OBI_2100338 obo:IAO_0000111 "liver function venous blood bilirubin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bilirubin in venous blood as part of a liver function order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver function venous blood bilirubin assay" ; rdfs:subClassOf obo:OBI_2100018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16990 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16990 ] ) ] . obo:OBI_2100339 obo:IAO_0000111 "liver function venous blood alanine aminotransferase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of alanine aminotransferase in venous blood as part of a liver function order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver function venous blood alanine aminotransferase assay" ; rdfs:subClassOf obo:OBI_2100016, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050219 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050219 ] ) ] . obo:OBI_2100340 obo:IAO_0000111 "liver function venous blood human aspartate aminotransferase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of human aspartate aminotransferase in venous blood as part of a liver function order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver function venous blood human aspartate aminotransferase assay" ; rdfs:subClassOf obo:OBI_2100019, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050353 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050353 ] ) ] . obo:OBI_2100341 obo:IAO_0000111 "liver function venous blood albumin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of albumin in venous blood as part of a liver function order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver function venous blood albumin assay" ; rdfs:subClassOf obo:OBI_2100022, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003918 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003918 ] ) ] . obo:OBI_2100342 obo:IAO_0000111 "liver function venous blood protein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of protein in venous blood as part of a liver function order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver function venous blood protein assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000000001 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000000001 ] ) ] . obo:OBI_2100343 obo:IAO_0000111 "liver function venous blood human alkaline phosphatase assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of human alkaline phosphatase in venous blood as part of a liver function order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver function venous blood human alkaline phosphatase assay" ; rdfs:subClassOf obo:OBI_2100017, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000050343 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000050343 ] ) ] . obo:OBI_2100344 obo:IAO_0000111 "vitamin B12 and Folate venous blood folic acid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of folic acid in venous blood as part of a vitamin B12 and Folate order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "vitamin B12 and Folate venous blood folic acid assay" ; rdfs:subClassOf obo:OBI_2100037, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_37445 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_37445 ] ) ] . obo:OBI_2100345 obo:IAO_0000111 "bodily fluid cell count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of cells in bodily fluid" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "bodily fluid cell count assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000009 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000009 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000000 ] ] . obo:OBI_2100346 obo:IAO_0000111 "venous blood reticulocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of reticulocytes in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood reticulocyte count assay" ; rdfs:subClassOf obo:OBI_0003026, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000558 ] ] . obo:OBI_2100347 obo:IAO_0000111 "bodily fluid cholesterol assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of cholesterol in bodily fluid" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "bodily fluid cholesterol assay" ; rdfs:subClassOf obo:OBI_2100031, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000009 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000009 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16113 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16113 ] ) ] . obo:OBI_2100348 obo:IAO_0000111 "TSH reflex Free T4 venous blood thyroid stimulating hormone assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of thyroid stimulating hormone in venous blood as part of a TSH reflex Free T4 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "TSH reflex Free T4 venous blood thyroid stimulating hormone assay" ; rdfs:subClassOf obo:OBI_2100033, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_81567 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_81567 ] ) ] . obo:OBI_2100349 obo:IAO_0000111 "direct venous blood bilirubin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bilirubin in venous blood as part of a direct order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "direct venous blood bilirubin assay" ; rdfs:subClassOf obo:OBI_2100018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16990 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16990 ] ) ] . obo:OBI_2100350 obo:IAO_0000111 "free venous blood T3 assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of T3 in venous blood as part of a free order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "free venous blood T3 assay" ; rdfs:subClassOf obo:OBI_2100046, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_28774 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_28774 ] ) ] . obo:OBI_2100351 obo:IAO_0000111 "bodily fluid albumin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of albumin in bodily fluid" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "bodily fluid albumin assay" ; rdfs:subClassOf obo:OBI_2100022, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000009 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000009 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003918 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003918 ] ) ] . obo:OBI_2100352 obo:IAO_0000111 "bodily fluid triglyceride assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of triglyceride in bodily fluid" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "bodily fluid triglyceride assay" ; rdfs:subClassOf obo:OBI_2100029, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000009 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000009 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17855 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17855 ] ) ] . obo:OBI_2100353 obo:IAO_0000111 "hemoglobin and hematocrit venous blood hematocrit assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the proportion of red blood cells in venous blood as part of a hemoglobin and hematocrit order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "hemoglobin and hematocrit venous blood hematocrit assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000232 ] ] . obo:OBI_2100354 obo:IAO_0000111 "hemoglobin and hematocrit venous blood hemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of hemoglobin in venous blood as part of a hemoglobin and hematocrit order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "hemoglobin and hematocrit venous blood hemoglobin assay" ; rdfs:subClassOf obo:OBI_2100014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] . obo:OBI_2100355 obo:IAO_0000111 "venous blood ionized calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of ionized calcium in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood ionized calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100356 obo:IAO_0000111 "venous blood temperature assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures temperature in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood temperature assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PATO_0000146 ] ] . obo:OBI_2100357 obo:IAO_0000111 "venous blood bicarbonate assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bicarbonate in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood bicarbonate assay" ; rdfs:subClassOf obo:OBI_2100043, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] . obo:OBI_2100358 obo:IAO_0000111 "venous blood oxygen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of oxygen in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood oxygen assay" ; rdfs:subClassOf obo:OBI_2100036, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] . obo:OBI_2100359 obo:IAO_0000111 "venous blood osmolality assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures osmolality in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood osmolality assay" ; rdfs:subClassOf obo:OBI_2100039, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PATO_0002027 ] ] . obo:OBI_2100360 obo:IAO_0000111 "liver fibrosis (chronic viral hepatitis) venous blood platelet count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of platelets in venous blood as part of a liver fibrosis (chronic viral hepatitis) order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver fibrosis (chronic viral hepatitis) venous blood platelet count assay" ; rdfs:subClassOf obo:OBI_0003028, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000233 ] ] . obo:OBI_2100361 obo:IAO_0000111 "venous blood T3 assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of T3 in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood T3 assay" ; rdfs:subClassOf obo:OBI_2100046, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_28774 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_28774 ] ) ] . obo:OBI_2100362 obo:IAO_0000111 "CBC with manual differential venous blood neutrophil count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of neutrophils in venous blood as part of a CBC with manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with manual differential venous blood neutrophil count assay" ; rdfs:subClassOf obo:OBI_0003022, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000775 ] ] . obo:OBI_2100363 obo:IAO_0000111 "creatinine clearance urine creatinine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of creatinine in urine as part of a creatinine clearance order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "creatinine clearance urine creatinine assay" ; rdfs:subClassOf obo:OBI_0003043, obo:OBI_2100003, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0000651 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000651 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16737 ] ) ] . obo:OBI_2100364 obo:IAO_0000111 "venous blood beta hydroxybutryic acid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of beta hydroxybutryic acid in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood beta hydroxybutryic acid assay" ; rdfs:subClassOf obo:OBI_2100051, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_20067 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_20067 ] ) ] . obo:OBI_2100365 obo:IAO_0000111 "venous blood megakaryocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of megakaryocytes in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood megakaryocyte count assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000556 ] ] . obo:OBI_2100366 obo:IAO_0000111 "venous blood nucleated RBC count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of nucleated RBCs in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood nucleated RBC count assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000562 ] ] . obo:OBI_2100367 obo:IAO_0000111 "venous blood WBC count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of WBCs in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood WBC count assay" ; rdfs:subClassOf obo:OBI_0001977, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000738 ] ] . obo:OBI_2100368 obo:IAO_0000111 "automated count venous blood reticulocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of reticulocytes in venous blood as part of a automated count order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "automated count venous blood reticulocyte count assay" ; rdfs:subClassOf obo:OBI_0003026, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000558 ] ] . obo:OBI_2100369 obo:IAO_0000111 "total venous blood homocysteine assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of homocysteine in venous blood as part of a total order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "total venous blood homocysteine assay" ; rdfs:subClassOf obo:OBI_0000443, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17230 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17230 ] ) ] . obo:OBI_2100370 obo:IAO_0000111 "venous blood Ceruloplasmin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of Ceruloplasmin in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood Ceruloplasmin assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000005794 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000005794 ] ) ] . obo:OBI_2100371 obo:IAO_0000111 "GEM4 arterial blood bicarbonate assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bicarbonate in arterial blood as part of a GEM4 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4 arterial blood bicarbonate assay" ; rdfs:subClassOf obo:OBI_2100043, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] . obo:OBI_2100372 obo:IAO_0000111 "GEM4 arterial blood lactic acid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures lactic acid in arterial blood as part of a GEM4 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4 arterial blood lactic acid assay" ; rdfs:subClassOf obo:OBI_2100042, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CHEBI_28358 ] ] . obo:OBI_2100373 obo:IAO_0000111 "GEM4 arterial blood hemoglobin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of hemoglobin in arterial blood as part of a GEM4 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4 arterial blood hemoglobin assay" ; rdfs:subClassOf obo:OBI_2100014, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] . obo:OBI_2100374 obo:IAO_0000111 "GEM4 arterial blood sodium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of sodium in arterial blood as part of a GEM4 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4 arterial blood sodium assay" ; rdfs:subClassOf obo:OBI_2100002, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29101 ] ) ] . obo:OBI_2100375 obo:IAO_0000111 "GEM4 arterial blood potassium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of potassium in arterial blood as part of a GEM4 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4 arterial blood potassium assay" ; rdfs:subClassOf obo:OBI_2100004, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_29103 ] ) ] . obo:OBI_2100376 obo:IAO_0000111 "GEM4 arterial blood temperature assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An assay that measures temperature in arterial blood as part of a GEM4 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4 arterial blood temperature assay" ; rdfs:subClassOf obo:OBI_0000070, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:PATO_0000146 ] ] . obo:OBI_2100377 obo:IAO_0000111 "GEM4 arterial blood glucose assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of glucose in arterial blood as part of a GEM4 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4 arterial blood glucose assay" ; rdfs:subClassOf obo:OBI_2100020, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17234 ] ) ] . obo:OBI_2100378 obo:IAO_0000111 "GEM4 arterial blood oxygen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of oxygen in arterial blood as part of a GEM4 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4 arterial blood oxygen assay" ; rdfs:subClassOf obo:OBI_2100036, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] . obo:OBI_2100379 obo:IAO_0000111 "GEM4 arterial blood hematocrit assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the proportion of red blood cells in arterial blood as part of a GEM4 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4 arterial blood hematocrit assay" ; rdfs:subClassOf obo:OBI_0003018, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000232 ] ] . obo:OBI_2100380 obo:IAO_0000111 "GEM4 arterial blood ionized calcium assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of ionized calcium in arterial blood as part of a GEM4 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4 arterial blood ionized calcium assay" ; rdfs:subClassOf obo:OBI_2100024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_39123 ] ) ] . obo:OBI_2100381 obo:IAO_0000111 "GEM4 arterial blood carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide in arterial blood as part of a GEM4 order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "GEM4 arterial blood carbon dioxide assay" ; rdfs:subClassOf obo:OBI_2100001, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:OBI_2100382 obo:IAO_0000111 "liver fibrosis (NAFLD) venous blood platelet count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of platelets in venous blood as part of a liver fibrosis (NAFLD) order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "liver fibrosis (NAFLD) venous blood platelet count assay" ; rdfs:subClassOf obo:OBI_0003028, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000233 ] ] . obo:OBI_2100383 obo:IAO_0000111 "venous blood beta hydroxybutric acid assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of beta hydroxybutric acid in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood beta hydroxybutric acid assay" ; rdfs:subClassOf obo:OBI_2100051, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_20067 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_20067 ] ) ] . obo:OBI_2100384 obo:IAO_0000111 "CBC with manual differential venous blood plasma cell count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of plasma cells in venous blood as part of a CBC with manual differential order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "CBC with manual differential venous blood plasma cell count assay" ; rdfs:subClassOf obo:OBI_0003024, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000786 ] ] . obo:OBI_2100385 obo:IAO_0000111 "venous blood erythropoietin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of erythropoietin in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood erythropoietin assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000007141 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000007141 ] ) ] . obo:OBI_2100386 obo:IAO_0000111 "blood gas arterial blood oxygen assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of oxygen in arterial blood as part of a blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "blood gas arterial blood oxygen assay" ; rdfs:subClassOf obo:OBI_2100036, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_33262 ] ) ] . obo:OBI_2100387 obo:IAO_0000111 "blood gas arterial blood bicarbonate assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of bicarbonate in arterial blood as part of a blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "blood gas arterial blood bicarbonate assay" ; rdfs:subClassOf obo:OBI_2100043, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17544 ] ) ] . obo:OBI_2100388 obo:IAO_0000111 "blood gas arterial blood carbon dioxide assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of carbon dioxide in arterial blood as part of a blood gas order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "blood gas arterial blood carbon dioxide assay" ; rdfs:subClassOf obo:OBI_2100001, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000013 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:OBI_2100389 obo:IAO_0000111 "free/total venous blood PSA assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of PSA in venous blood as part of a free/total order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "free/total venous blood PSA assay" ; rdfs:subClassOf obo:OBI_2100034, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003015 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000003015 ] ) ] . obo:OBI_2100390 obo:IAO_0000111 "cerebrospinal fluid lymphocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of lymphocytes in cerebrospinal fluid" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "cerebrospinal fluid lymphocyte count assay" ; rdfs:subClassOf obo:OBI_0003024, obo:OBI_0003232, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002502 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002502 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000542 ] ] . obo:OBI_2100391 obo:IAO_0000111 "cerebrospinal fluid segmented neutrophil count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of segmented neutrophils in cerebrospinal fluid" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "cerebrospinal fluid segmented neutrophil count assay" ; rdfs:subClassOf obo:OBI_0003022, obo:OBI_0003232, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002502 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002502 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0011114 ] ] . obo:OBI_2100392 obo:IAO_0000111 "cerebrospinal fluid mesothelial cell count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of mesothelial cells in cerebrospinal fluid" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "cerebrospinal fluid mesothelial cell count assay" ; rdfs:subClassOf obo:OBI_0001977, obo:OBI_0003232, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002502 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002502 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000077 ] ] . obo:OBI_2100393 obo:IAO_0000111 "cerebrospinal fluid macrophage count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of macrophages in cerebrospinal fluid" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "cerebrospinal fluid macrophage count assay" ; rdfs:subClassOf obo:OBI_0003027, obo:OBI_0003232, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002502 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002502 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000235 ] ] . obo:OBI_2100394 obo:IAO_0000111 "cerebrospinal fluid basophil count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of basophils in cerebrospinal fluid" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "cerebrospinal fluid basophil count assay" ; rdfs:subClassOf obo:OBI_0003021, obo:OBI_0003232, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002502 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002502 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000767 ] ] . obo:OBI_2100395 obo:IAO_0000111 "cerebrospinal fluid monocyte count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of monocytes in cerebrospinal fluid" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "cerebrospinal fluid monocyte count assay" ; rdfs:subClassOf obo:OBI_0003025, obo:OBI_0003232, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002502 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002502 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000576 ] ] . obo:OBI_2100396 obo:IAO_0000111 "cerebrospinal fluid eosinophil count assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A cytometry assay that measures the count of eosinophils in cerebrospinal fluid" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "cerebrospinal fluid eosinophil count assay" ; rdfs:subClassOf obo:OBI_0003023, obo:OBI_0003232, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0002502 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002502 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:IAO_0000136 ; owl:someValuesFrom obo:CL_0000771 ] ] . obo:OBI_2100397 obo:IAO_0000111 "venous blood beta-2-microglobulin assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of beta-2-microglobulin in venous blood" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "venous blood beta-2-microglobulin assay" ; rdfs:subClassOf obo:OBI_2100023, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000004580 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:PR_000004580 ] ) ] . obo:OBI_2100398 obo:IAO_0000111 "lipid panel reflex direct venous blood low density lipoprotein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of low density lipoprotein in venous blood as part of a Lipid panel reflex direct order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "lipid panel reflex direct venous blood low density lipoprotein assay" ; rdfs:subClassOf obo:OBI_2100032, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_47774 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_47774 ] ) ] . obo:OBI_2100399 obo:IAO_0000111 "lipid panel reflex direct venous blood triglyceride assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of triglyceride in venous blood as part of a Lipid panel reflex direct order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "lipid panel reflex direct venous blood triglyceride assay" ; rdfs:subClassOf obo:OBI_2100029, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_17855 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_17855 ] ) ] . obo:OBI_2100400 obo:IAO_0000111 "lipid panel reflex direct venous blood cholesterol assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of cholesterol in venous blood as part of a Lipid panel reflex direct order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "lipid panel reflex direct venous blood cholesterol assay" ; rdfs:subClassOf obo:OBI_2100031, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_16113 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_16113 ] ) ] . obo:OBI_2100401 obo:IAO_0000111 "lipid panel reflex direct venous blood high density lipoprotein assay" ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "An analyte assay that measures the abundance of high density lipoprotein in venous blood as part of a Lipid panel reflex direct order" ; obo:IAO_0000117 "Mark A. Miller, ORCID:0000-0001-9076-6066 & Chris Stoeckert, ORCID ORCID:0000-0002-5714-991X" ; obo:IAO_0000119 "PennTURBO team" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1253" ; a owl:Class ; rdfs:label "lipid panel reflex direct venous blood high density lipoprotein assay" ; rdfs:subClassOf obo:OBI_2100030, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_2000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_2000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000275 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_47775 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_47775 ] ) ] . obo:OBI_2100402 obo:IAO_0000111 "pooled clone sequencing assay" ; obo:IAO_0000112 "Although a similar pooled clone sequencing method has recently been described by others for metagenome-derived medium-insert plasmids and large-insert fosmids, to our knowledge, we are the first to report the pooled strategy for sequencing of large-insert metagenomic clones while also critically evaluating the performance of this pooled strategy by comparing the results to barcoded reference sequences of the same clones." ; obo:IAO_0000114 obo:IAO_0000120 ; obo:IAO_0000115 "A DNA sequencing assay in which the DNA input is derived from pooled clones (for example BACs and Fosmids) is sequenced." ; obo:IAO_0000117 "Dan Berrios, ORCID: 0000-0003-4312-9552" ; obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049660/" ; obo:IAO_0000233 "https://github.com/obi-ontology/obi/issues/1106" ; obo:IAO_0000234 "Bonita Lam" ; a owl:Class ; rdfs:label "pooled clone sequencing assay" ; rdfs:subClassOf obo:OBI_0000626, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:BFO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:OBI_0400103 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:OBI_0400103 ] ) ], [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000067 [ a owl:Restriction ; owl:onProperty obo:RO_0000081 ; owl:someValuesFrom obo:OBI_0001051 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0001051 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:OBI_0000067 ] ) ] ] ) ], [ a owl:Restriction ; owl:onProperty obo:OBI_0000299 ; owl:someValuesFrom obo:OBI_0001573 ] . obo:OBI_9991118 obo:IAO_0000111 "IEDB alternative term" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An alternative term used by the IEDB." ; obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters" ; obo:IAO_0000119 "IEDB" ; a owl:AnnotationProperty ; rdfs:label "IEDB alternative term" ; rdfs:subPropertyOf obo:IAO_0000118 . obo:OBI_9991119 obo:IAO_0000111 "FGED alternative term" ; obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "An alternative term used by the Functional Genomics Data (FGED) Society." ; obo:IAO_0000117 "PERSON: Chris Stoeckert, Jie Zheng" ; obo:IAO_0000119 "Penn Group" ; a owl:AnnotationProperty ; rdfs:label "FGED alternative term" ; rdfs:subPropertyOf obo:IAO_0000118 . obo:OBI_9999994 obo:IAO_0000111 "chromium release assay" ; obo:IAO_0000112 "Autologous EBV-transformed B-LCL were used as target cells for the influenza virus-specific CTL assays. Equal volumes of target and effector cells were added to triplicate wells of 96-well tissue culture plates, and 1:2 serial dilutions of effectors were made, producing effector-to-target (E:T) ratios of 100:1, 50:1, 25:1, and 12.5:1. After a 4-h incubation of the effector cells with the target cells, supernatants were collected following brief centrifugation and transferred to polystyrene tubes to be counted with the LKB 1272 Clinigamma counter (Wallac). Percent specific killing was determined with the following equation: (experimental 51Cr release - spontaneous 51Cr release)/(maximum 51Cr release - spontaneous 51Cr release) x 100." ; obo:IAO_0000114 obo:IAO_0000123 ; obo:IAO_0000115 "An in vitro cell killing assay in which radioactive chromium is absorbed by cells and released into supernatant when the cells die. The amount of radioactivity measured in the supernatant is a proxy for the number of cells that have died." ; obo:IAO_0000117 "IEDB", "PlanAndPlannedProcess Branch" ; a owl:Class ; rdfs:label "chromium release assay" ; rdfs:subClassOf obo:OBI_0000903, [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0002743 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_50076 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:OBI_0000293 ; owl:someValuesFrom obo:CHEBI_50076 ] ) ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:OBI_0000201 obo:OBI_0003368 ) ] ] . obo:OGMS_0000015 obo:IAO_0000111 "clinical history" ; obo:IAO_0000115 "A series of statements representing health-relevant qualities of a patient and of a patient's family."@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "clinical history" ; rdfs:subClassOf obo:IAO_0000030 . obo:OGMS_0000023 obo:IAO_0000111 "phenotype" ; obo:IAO_0000115 "A (combination of) quality(ies) of an organism determined by the interaction of its genetic make-up and environment that differentiates specific instances of a species from other instances of the same species."@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "phenotype" ; rdfs:subClassOf obo:BFO_0000019 . obo:OGMS_0000031 obo:IAO_0000111 "disease" ; obo:IAO_0000115 "A disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism."@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "disease" ; rdfs:subClassOf obo:BFO_0000016 . obo:OGMS_0000063 obo:IAO_0000111 "disease course" ; obo:IAO_0000115 "The totality of all processes through which a given disease instance is realized."@en ; obo:IAO_0000232 """replace 'OBI:occurrence of disease', need to add logical definition The axioms of OBI occurence of disease: Equivalent classes: realizes some disease Superclasses: 'has part' some 'pathologic process' 'has participant' some (organism and ('has role' some 'host of immune response role')) biological_process realizes some 'host of immune response role'""" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "disease course" ; rdfs:subClassOf obo:GO_0008150 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000055 ; owl:someValuesFrom obo:OGMS_0000031 ] . obo:OGMS_0000073 obo:IAO_0000111 "diagnosis" ; obo:IAO_0000115 "The representation of a conclusion of a diagnostic process."@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "diagnosis" ; rdfs:subClassOf obo:IAO_0000027 . obo:OGMS_0000090 obo:IAO_0000111 "treatment" ; obo:IAO_0000115 "A planned process whose completion is hypothesized by a health care provider to eliminate, prevent, or alleviate a disorder, the signs and symptoms of a disorder, or a pathological process"@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "treatment" ; rdfs:subClassOf obo:OBI_0000011 . obo:OGMS_0000123 obo:IAO_0000111 "clinical data item"@en ; obo:IAO_0000115 "A data item that is about a patient and is the specified output of a health care process assay or diagnostic process" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "clinical data item"@en ; rdfs:subClassOf obo:IAO_0000027 . obo:OMIABIS_0000050 obo:IAO_0000111 "fixed tissue specimen"@en ; obo:IAO_0000115 "A processed specimen that is the output of a fixation process."@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "fixed tissue specimen"@en ; rdfs:subClassOf obo:OBI_0000953 . obo:OMIABIS_0000052 obo:IAO_0000111 "fixed tissue slide specimen"@en ; obo:IAO_0000115 "A fixed tissue specimen that is placed in a slide."@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "fixed tissue slide specimen"@en ; rdfs:subClassOf obo:OMIABIS_0000050 . obo:OMRSE_00000012 obo:IAO_0000111 "health care provider role"@en ; obo:IAO_0000115 "A human health care role inhering in an organization or human being that is realized by a process of providing health care services to an organism."@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "health care provider role"@en ; rdfs:subClassOf obo:BFO_0000023 . obo:OPL_0000232 obo:IAO_0000111 "parasite organism" ; obo:IAO_0000115 "An organism living in, with, or on another organism in parasitism. Individual members of parasite species, such as Leishmania, Plasmodium, Trypanosoma, etc. are members of this class." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "parasite organism" ; rdfs:subClassOf obo:OBI_0100026 . obo:OPL_0000267 obo:IAO_0000111 "Plasmodium gametocyte" ; obo:IAO_0000115 "A Plasmodium that is located either in the bloodstream of the vertebrate host or midgut of mosquito vector during gametocyte stage. Gametocytes are the precursor cells of the macro- or microgametes" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Plasmodium gametocyte" ; rdfs:subClassOf obo:NCBITaxon_5820 . obo:PATO_0000011 obo:IAO_0000111 "age" ; obo:IAO_0000115 "A time quality inhering in a bearer by virtue of how long the bearer has existed." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "age" ; rdfs:subClassOf obo:PATO_0000165 . obo:PATO_0000018 obo:IAO_0000111 "fluorescence" ; obo:IAO_0000115 "A luminous flux quality inhering in a bearer by virtue of the bearer's emitting longer wavelength light following the absorption of shorter wavelength radiation; fluorescence is common with aromatic compounds with several rings joined together." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "fluorescence" ; rdfs:subClassOf obo:PATO_0001296 . obo:PATO_0000025 obo:IAO_0000111 "composition" ; obo:IAO_0000115 "A single physical entity inhering in an bearer by virtue of the bearer's quantities or relative ratios of subparts." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "composition" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0000033 obo:IAO_0000111 "concentration of" ; obo:IAO_0000115 "A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "concentration of" ; rdfs:subClassOf obo:PATO_0002182 . obo:PATO_0000047 obo:IAO_0000111 "biological sex" ; obo:IAO_0000115 "An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "biological sex" ; rdfs:subClassOf obo:PATO_0001995 . obo:PATO_0000051 obo:IAO_0000111 "morphology" ; obo:IAO_0000115 "A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "morphology" ; rdfs:subClassOf obo:PATO_0001241 . obo:PATO_0000117 obo:IAO_0000111 "size" ; obo:IAO_0000115 "A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "size" ; rdfs:subClassOf obo:PATO_0000051 . obo:PATO_0000122 obo:IAO_0000111 "length" ; obo:IAO_0000115 "A 1-D extent quality which is equal to the distance between two points." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "length" ; rdfs:subClassOf obo:PATO_0000051 . obo:PATO_0000125 obo:IAO_0000111 "mass" ; obo:IAO_0000115 "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mass" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0000140 obo:IAO_0000111 "position" ; obo:IAO_0000115 "A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "position" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0000141 obo:IAO_0000111 "structure" ; obo:IAO_0000115 "A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "structure" ; rdfs:subClassOf obo:PATO_0000051 . obo:PATO_0000146 obo:IAO_0000111 "temperature" ; obo:IAO_0000115 "A physical quality of the thermal energy of a system." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "temperature" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0000165 obo:IAO_0000111 "time" ; obo:IAO_0000115 "A quality in which events occur in sequence." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "time" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0000169 obo:IAO_0000111 "viability" ; obo:IAO_0000115 "An organismal quality inhering in a bearer or a population by virtue of the bearer's disposition to survive and develop normally or the number of surviving individuals in a given population." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "viability" ; rdfs:subClassOf obo:PATO_0001995 . obo:PATO_0000186 obo:IAO_0000111 "behavioral quality" ; obo:IAO_0000115 "An organismal quality inhering in a bearer by virtue of the bearer's behavior aggregate of the responses or reactions or movements in a given situation." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "behavioral quality" ; rdfs:subClassOf obo:PATO_0001995 . obo:PATO_0000383 obo:IAO_0000111 "female" ; obo:IAO_0000115 "A biological sex quality inhering in an individual or a population that only produces gametes that can be fertilised by male gametes." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "female" ; rdfs:subClassOf obo:PATO_0001894 . obo:PATO_0000384 obo:IAO_0000111 "male" ; obo:IAO_0000115 "A biological sex quality inhering in an individual or a population whose sex organs contain only male gametes." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "male" ; rdfs:subClassOf obo:PATO_0001894 . obo:PATO_0000918 obo:IAO_0000111 "volume" ; obo:IAO_0000115 "A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "volume" ; rdfs:subClassOf obo:PATO_0001710 . obo:PATO_0001018 obo:IAO_0000111 "physical quality" ; obo:IAO_0000115 "A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "physical quality" ; rdfs:subClassOf obo:PATO_0001241 . obo:PATO_0001020 obo:IAO_0000111 "damage" ; obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of whether the bearer has been harmed or injured or spoiled." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "damage" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0001025 obo:IAO_0000111 "pressure" ; obo:IAO_0000115 "A physical quality that inheres in a bearer by virtue of the bearer's amount of force per unit area it exerts." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "pressure" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0001161 obo:IAO_0000111 "diluted" ; obo:IAO_0000115 "A concentration which relatively low." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "diluted" ; rdfs:subClassOf obo:PATO_0000033 . obo:PATO_0001167 obo:IAO_0000111 "damaged" ; obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer being harmed or injured or spoiled, such that its functionality is impaired." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "damaged" ; rdfs:subClassOf obo:PATO_0001020 . obo:PATO_0001193 obo:IAO_0000111 "lateral to" ; obo:IAO_0000115 "A spatial quality inhering in a bearer by virtue of the bearer's being located toward the side relative to another entity." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "lateral to" ; rdfs:subClassOf obo:PATO_0000140 . obo:PATO_0001196 obo:IAO_0000111 "ventral to" ; obo:IAO_0000115 "A spatial quality inhering in a bearer by virtue of the bearer's being located toward the abdomen of an organism relative to another entity." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ventral to" ; rdfs:subClassOf obo:PATO_0000140 . obo:PATO_0001233 obo:IAO_0000111 "dorsal to" ; obo:IAO_0000115 "A spatial quality inhering in a bearer by virtue of the bearer's being located toward the back or upper surface of an organism relative to another entity." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "dorsal to" ; rdfs:subClassOf obo:PATO_0000140 . obo:PATO_0001241 obo:IAO_0000111 "physical object quality" ; obo:IAO_0000115 "A quality which inheres in a continuant." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "physical object quality" ; rdfs:subClassOf obo:BFO_0000019 . obo:PATO_0001291 obo:IAO_0000111 "electromagnetic (EM) radiation quality" ; obo:IAO_0000115 "A physical quality that inheres in an bearer by virtue of how that bearer interacts with electromagnetic radiation." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "electromagnetic (EM) radiation quality" ; rdfs:subClassOf obo:PATO_0001739 . obo:PATO_0001296 obo:IAO_0000111 "luminous flux" ; obo:IAO_0000115 "A scalar optical quality which obtains by the magnitude of the light emitted by the bearer." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "luminous flux" ; rdfs:subClassOf obo:PATO_0001300 . obo:PATO_0001300 obo:IAO_0000111 "optical quality" ; obo:IAO_0000115 "An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "optical quality" ; rdfs:subClassOf obo:PATO_0001291 . obo:PATO_0001335 obo:IAO_0000111 "bacterial mating type" ; obo:IAO_0000115 "A mating type that indicates whether the F plasmid has integrated into the chromosome." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "bacterial mating type" ; rdfs:subClassOf obo:PATO_0001895 . obo:PATO_0001337 obo:IAO_0000111 "yeast mating type" ; obo:IAO_0000115 "A yeast mating type." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "yeast mating type" ; rdfs:subClassOf obo:PATO_0001895 . obo:PATO_0001338 obo:IAO_0000111 "mixed sex" ; obo:IAO_0000115 "A biological sex quality inhering in a population of multiple sexes." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mixed sex" ; rdfs:subClassOf obo:PATO_0002003 . obo:PATO_0001339 obo:IAO_0000111 "biomaterial purity" ; obo:IAO_0000115 "A composition quality inhering in an bearer by virtue of the bearer's homogeneity of a biomaterial." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "biomaterial purity" ; rdfs:subClassOf obo:PATO_0000025 . obo:PATO_0001340 obo:IAO_0000111 "hermaphrodite" ; obo:IAO_0000115 "A biological sex quality inhering in an organism or a population with both male and female sexual organs in one individual." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "hermaphrodite" ; rdfs:subClassOf obo:PATO_0001894 . obo:PATO_0001341 obo:IAO_0000111 "a mating type (yeast)" ; obo:IAO_0000115 "A S. cerevisiae mating type cells that secrete a pheromone that in alpha haploids stimulates processes that lead to mating." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "a mating type (yeast)" ; rdfs:subClassOf obo:PATO_0001342 . obo:PATO_0001342 obo:IAO_0000111 "Saccharomyces cerevisiae mating type" ; obo:IAO_0000115 "A S. cerevisiae mating type." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Saccharomyces cerevisiae mating type" ; rdfs:subClassOf obo:PATO_0001337 . obo:PATO_0001343 obo:IAO_0000111 "Schizosaccharomyces pombe mating type" ; obo:IAO_0000115 "A S. pombe mating type determined by the gene configuration on the mat1 locus." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "Schizosaccharomyces pombe mating type" ; rdfs:subClassOf obo:PATO_0001337 . obo:PATO_0001344 obo:IAO_0000111 "alpha mating type (yeast)" ; obo:IAO_0000115 "A S. cerevisiae mating type cells that secrete a pheromone that stimulates a haploids." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "alpha mating type (yeast)" ; rdfs:subClassOf obo:PATO_0001342 . obo:PATO_0001345 obo:IAO_0000111 "h minus" ; obo:IAO_0000115 "A S. pombe mating type determined by the mat1-Mc and mat1-Mi on the mat1 locus." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "h minus" ; rdfs:subClassOf obo:PATO_0001343 . obo:PATO_0001346 obo:IAO_0000111 "h plus" ; obo:IAO_0000115 "A S. pombe mating type determined by the mat1-Pc and mat1-Pi on the mat1 locus." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "h plus" ; rdfs:subClassOf obo:PATO_0001343 . obo:PATO_0001347 obo:IAO_0000111 "F mating type" ; obo:IAO_0000115 "A bacterial mating type indicating the presence of F plasmid in a bacterial cell." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "F mating type" ; rdfs:subClassOf obo:PATO_0001335 . obo:PATO_0001348 obo:IAO_0000111 "F minus mating type" ; obo:IAO_0000115 "A bacterial mating type indicating the absence of F plasmid in a bacterial cell." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "F minus mating type" ; rdfs:subClassOf obo:PATO_0001335 . obo:PATO_0001374 obo:IAO_0000111 "ploidy" ; obo:IAO_0000115 "A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ploidy" ; rdfs:subClassOf obo:PATO_0001396 . obo:PATO_0001375 obo:IAO_0000111 "haploid" ; obo:IAO_0000115 "A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "haploid" ; rdfs:subClassOf obo:PATO_0001393 . obo:PATO_0001377 obo:IAO_0000111 "polyploid" ; obo:IAO_0000115 "A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "polyploid" ; rdfs:subClassOf obo:PATO_0001393 . obo:PATO_0001385 obo:IAO_0000111 "aneuploid" ; obo:IAO_0000115 "A ploidy quality inhering in a bearer by virtue of the bearer's containing a non-integral multiple of the monoploid number, due to extra or missing chromosomes." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "aneuploid" ; rdfs:subClassOf obo:PATO_0001374 . obo:PATO_0001393 obo:IAO_0000111 "euploid" ; obo:IAO_0000115 "A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "euploid" ; rdfs:subClassOf obo:PATO_0001374 . obo:PATO_0001394 obo:IAO_0000111 "diploid" ; obo:IAO_0000115 "A ploidy quality inhering in a bearer by virtue of the bearer's having two copies (homologs) of each chromosome, usually one from the mother and one from the father." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "diploid" ; rdfs:subClassOf obo:PATO_0001393 . obo:PATO_0001396 obo:IAO_0000111 "cellular quality" ; obo:IAO_0000115 "A monadic quality of continuant that exists at the cellular level of organisation." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cellular quality" ; rdfs:subClassOf obo:PATO_0001241 . obo:PATO_0001421 obo:IAO_0000111 "alive" ; obo:IAO_0000115 "A viability quality inhering in a bearer by virtue of the bearer's condition before death." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "alive" ; rdfs:subClassOf obo:PATO_0000169 . obo:PATO_0001422 obo:IAO_0000111 "dead" ; obo:IAO_0000115 "A viability quality inhering in a bearer by virtue of the cessation of the bearer's life." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "dead" ; rdfs:subClassOf obo:PATO_0000169 . obo:PATO_0001546 obo:IAO_0000111 "quality of a solid" ; obo:IAO_0000115 "A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity characterized by particles arranged such that their shape and volume are relatively stable." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "quality of a solid" ; rdfs:subClassOf obo:PATO_0002198 . obo:PATO_0001547 obo:IAO_0000111 "quality of a gas" ; obo:IAO_0000115 "A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity consisting of particles that have neither a defined volume nor defined shape." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "quality of a gas" ; rdfs:subClassOf obo:PATO_0002198 . obo:PATO_0001548 obo:IAO_0000111 "quality of a liquid" ; obo:IAO_0000115 "A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "quality of a liquid" ; rdfs:subClassOf obo:PATO_0002198 . obo:PATO_0001574 obo:IAO_0000111 "flow rate" ; obo:IAO_0000115 "A physical quality inhering in a bearer by virtue of the bearer's motion characteristic." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "flow rate" ; rdfs:subClassOf obo:PATO_0001906 . obo:PATO_0001632 obo:IAO_0000111 "anterior to" ; obo:IAO_0000115 "A spatial quality inhering in a bearer by virtue of the bearer's being located toward the front of an organism relative to another entity." ; obo:IAO_0000118 "frontal"@en ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "anterior to" ; rdfs:subClassOf obo:PATO_0000140 . obo:PATO_0001710 obo:IAO_0000111 "3-D extent" ; obo:IAO_0000115 "A size quality inhering in an bearer by virtue of the bearer's extension in three dimensions." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "3-D extent" ; rdfs:subClassOf obo:PATO_0000117 . obo:PATO_0001739 obo:IAO_0000111 "radiation quality" ; obo:IAO_0000115 "A quality that inheres in an bearer by virtue of how that bearer interacts with radiation." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "radiation quality" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0001740 obo:IAO_0000111 "activity (of a radionuclide)" ; obo:IAO_0000115 "A radiation quality inhering in a radioactive substance by virtue of its transformation (disintegration) rate." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "activity (of a radionuclide)" ; rdfs:subClassOf obo:PATO_0001739 . obo:PATO_0001741 obo:IAO_0000111 "radioactive" ; obo:IAO_0000115 "A radiation quality inhering in bearer by virtue of the bearer's exhibiting or being caused by radioactivity." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "radioactive" ; rdfs:subClassOf obo:PATO_0001740 . obo:PATO_0001792 obo:IAO_0000111 "left side of" ; obo:IAO_0000115 "A spatial quality inhering in a bearer by virtue of the bearer's being located on left side of from the a another entity." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "left side of" ; rdfs:subClassOf obo:PATO_0000140 . obo:PATO_0001793 obo:IAO_0000111 "right side of" ; obo:IAO_0000115 "A spatial quality inhering in a bearer by virtue of the bearer's being located on right side of a another entity." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "right side of" ; rdfs:subClassOf obo:PATO_0000140 . obo:PATO_0001894 obo:IAO_0000111 "phenotypic sex" ; obo:IAO_0000115 "An organismal quality inhering in a bearer by virtue of the bearer's physical expression of sexual characteristics." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "phenotypic sex" ; rdfs:subClassOf obo:PATO_0000047 . obo:PATO_0001895 obo:IAO_0000111 "mating type" ; obo:IAO_0000115 "A biological sex quality inhering in an individual or a population that undergo sexual reproduction." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mating type" ; rdfs:subClassOf obo:PATO_0000047 . obo:PATO_0001906 obo:IAO_0000111 "movement quality" ; obo:IAO_0000115 "A physical quality inhering in a bearer by virtue of the bearer's participation in movement." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "movement quality" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0001985 obo:IAO_0000111 "frozen" ; obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's being kept below its freezing point." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "frozen" ; rdfs:subClassOf obo:PATO_0000146 . obo:PATO_0001995 obo:IAO_0000111 "organismal quality" ; obo:IAO_0000115 "A quality that inheres in an entire organism or part of an organism." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "organismal quality" ; rdfs:subClassOf obo:PATO_0001241 . obo:PATO_0002003 obo:IAO_0000111 "population quality" ; obo:IAO_0000115 "A quality that inheres in an entire population or part of a population." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "population quality" ; rdfs:subClassOf obo:PATO_0001241 . obo:PATO_0002027 obo:IAO_0000111 "osmolality" ; obo:IAO_0000115 "A concentration quality inhering in a bearer by virtue of the bearer's amount of osmoles of solute per kilogram of solvent." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "osmolality" ; rdfs:subClassOf obo:PATO_0000033 . obo:PATO_0002182 obo:IAO_0000111 "molecular quality" ; obo:IAO_0000115 "A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "molecular quality" ; rdfs:subClassOf obo:PATO_0001241 . obo:PATO_0002198 obo:IAO_0000111 "quality of a substance" ; obo:IAO_0000115 "A quality inhering in a bearer by virtue of its constitution." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "quality of a substance" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0002201 obo:IAO_0000111 "handedness" ; obo:IAO_0000115 "A behavioral quality inhering ina bearer by virtue of the bearer's unequal distribution of fine motor skill between its left and right hands or feet." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "handedness" ; rdfs:subClassOf obo:PATO_0000186 . obo:PATO_0002202 obo:IAO_0000111 "left handedness" ; obo:IAO_0000115 "Handedness where the organism preferentially uses the left hand or foot for tasks requiring the use of a single hand or foot or a dominant hand or foot." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "left handedness" ; rdfs:subClassOf obo:PATO_0002201 . obo:PATO_0002203 obo:IAO_0000111 "right handedness" ; obo:IAO_0000115 "Handedness where the organism preferentially uses the right hand or foot for tasks requiring the use of a single hand or foot or a dominant hand or foot." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "right handedness" ; rdfs:subClassOf obo:PATO_0002201 . obo:PATO_0002204 obo:IAO_0000111 "ambidextrous handedness" ; obo:IAO_0000115 "Handedness where the organism exhibits no overall dominance in the use of right or left hand or foot in the performance of tasks that require one hand or foot or a dominant hand or foot." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ambidextrous handedness" ; rdfs:subClassOf obo:PATO_0002201 . obo:PATO_0002243 obo:IAO_0000111 "fluid flow rate" ; obo:IAO_0000115 "A physical quality inhering in a fluid (liquid or gas) by virtue of the amount of fluid which passes through a given surface per unit time." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "fluid flow rate" ; rdfs:subClassOf obo:PATO_0001574 . obo:PR_000000001 obo:IAO_0000111 "protein" ; obo:IAO_0000112 "antithrombin III is a protein" ; obo:IAO_0000115 "An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "protein" ; rdfs:subClassOf obo:CHEBI_16670 . obo:PR_000001004 obo:IAO_0000111 "CD4 molecule" ; obo:IAO_0000115 "A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "CD4 molecule" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001018 obo:IAO_0000111 "CD3 subunit with immunoglobulin domain" ; obo:IAO_0000115 "A protein with a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "CD3 subunit with immunoglobulin domain" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000003015 obo:IAO_0000111 "prostate-specific antigen" ; obo:IAO_0000115 "A trypsin that is a translation product of the human KLK3 gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "prostate-specific antigen" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000003252 obo:IAO_0000111 "antithrombin-III" ; obo:IAO_0000115 "A serpin that is a translation product of the human SERPINC1 gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "antithrombin-III" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000003745 obo:IAO_0000111 "double-stranded RNA-specific adenosine deaminase" ; obo:IAO_0000115 "A protein that is a translation product of the human ADAR gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "double-stranded RNA-specific adenosine deaminase" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000003777 obo:IAO_0000111 "adiponectin" ; obo:IAO_0000115 "A protein that is a translation product of the human ADIPOQ gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "adiponectin" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000003918 obo:IAO_0000111 "albumin" ; obo:IAO_0000115 "A protein that is a translation product of the human ALB gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "albumin" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000004580 obo:IAO_0000111 "beta-2-microglobulin" ; obo:IAO_0000115 "A protein that is a translation product of the human B2M gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "beta-2-microglobulin" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000005794 obo:IAO_0000111 "ceruloplasmin" ; obo:IAO_0000115 "A protein that is a translation product of the human CP gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ceruloplasmin" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000005897 obo:IAO_0000111 "C-reactive protein" ; obo:IAO_0000115 "A protein that is a translation product of the human CRP gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "C-reactive protein" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000006592 obo:IAO_0000111 "deoxyribonuclease-1" ; obo:IAO_0000115 "A protein that is a translation product of the human DNASE1 gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "deoxyribonuclease-1" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000007141 obo:IAO_0000111 "erythropoietin" ; obo:IAO_0000115 "A protein that is a translation product of the human EPO gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "erythropoietin" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000007928 obo:IAO_0000111 "glial cell line-derived neurotrophic factor" ; obo:IAO_0000115 "A protein that is a translation product of the human GDNF gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "glial cell line-derived neurotrophic factor" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000008457 obo:IAO_0000111 "beta-globin" ; obo:IAO_0000115 "A hemoglobin subunit that is a translation product of the human HBB gene, a 1:1 ortholog thereof, or pro-orthologs thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "beta-globin" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000008725 obo:IAO_0000111 "haptoglobin" ; obo:IAO_0000115 "A protein that is a translation product of the human HP gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "haptoglobin" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000009758 obo:IAO_0000111 "leptin" ; obo:IAO_0000115 "A protein that is a translation product of the human LEP gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "leptin" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000013429 obo:IAO_0000111 "parathyroid hormone" ; obo:IAO_0000115 "A protein that is a translation product of the human PTH gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "parathyroid hormone" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000014060 obo:IAO_0000111 "ribonuclease T2" ; obo:IAO_0000115 "A protein that is a translation product of the human RNASET2 gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ribonuclease T2" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000016261 obo:IAO_0000111 "serotransferrin" ; obo:IAO_0000115 "A protein that is a translation product of the human TF gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "serotransferrin" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000016801 obo:IAO_0000111 "transthyretin" ; obo:IAO_0000115 "A protein that is a translation product of the human TTR gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "transthyretin" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000023089 obo:IAO_0000111 "DNA ligase" ; obo:IAO_0000115 "A protein that is a translation product of the Escherichia coli K-12 ligA gene or a 1:1 ortholog thereof." ; obo:IAO_0000116 "Definition defined by OBI developers: an enzyme that covalently joins two compatible pieces of DNA through the cleavage of an ATP molecule" ; obo:IAO_0000118 "ligase" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "DNA ligase" ; rdfs:subClassOf obo:OBI_0000427, obo:PR_000000001, [ a owl:Restriction ; owl:onProperty obo:RO_0000085 ; owl:someValuesFrom [ a owl:Restriction ; owl:allValuesFrom obo:GO_0003824 ; owl:onProperty obo:BFO_0000054 ] ] . obo:PR_000025402 obo:IAO_0000111 "T cell receptor co-receptor CD8" ; obo:IAO_0000115 "A protein-containing complex that is a membrane-bound heterodimeric co-receptor for MHC class-I antigen/T-cell receptor interaction." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "T cell receptor co-receptor CD8" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000025467 obo:IAO_0000111 "guanyl-specific ribonuclease T1" ; obo:IAO_0000115 "A protein that is a translation product of the Aspergillus oryzae RIB40 rntA gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "guanyl-specific ribonuclease T1" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000025471 obo:IAO_0000111 "nuclease S1" ; obo:IAO_0000115 "A protein that is a translation product of the Aspergillus oryzae RIB40 nucS gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "nuclease S1" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000025475 obo:IAO_0000111 "ribonuclease U2" ; obo:IAO_0000115 "A protein that is a translation product of the Ustilago sphaerogena RNU2 gene or a 1:1 ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ribonuclease U2" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000025477 obo:IAO_0000111 "ribonuclease V1 (cobra)" ; obo:IAO_0000115 "A protein with ribonuclease activity that is a constituent of cobra venom." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ribonuclease V1 (cobra)" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000025478 obo:IAO_0000111 "ribonuclease CL3 (chicken)" ; obo:IAO_0000115 "A protein with ribonuclease activity that is purified from chicken liver." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ribonuclease CL3 (chicken)" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000027247 obo:IAO_0000111 "cytosolic creatine kinase complex, MB-type" ; obo:IAO_0000115 "A cytosolic creatine kinase complex that is a heterodimer of a B-type subunit and an M-type subunit." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cytosolic creatine kinase complex, MB-type" ; rdfs:subClassOf obo:GO_0032991 . obo:PR_000029971 obo:IAO_0000111 "creatine kinase" ; obo:IAO_0000115 "A protein that contains a single ATP:guanido phosphotransferase N-terminal domain (Pfam:PF02807) followed by a single ATP:guanido phosphotransferase C-terminal catalytic domain (Pfam:PF00217)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "creatine kinase" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000029983 obo:IAO_0000111 "protein-glutamine gamma-glutamyltransferase" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "protein-glutamine gamma-glutamyltransferase" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000036824 obo:IAO_0000111 "NS1" ; obo:IAO_0000115 "A dengue virus genome polyprotein proteolytic cleavage product that is the N-terminal most non-structural protein within the dengue virus genome polyprotein. Example: UniProtKB:P29990, 776-1127, Asn-905/Asn-982, MOD:00160." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "NS1" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000050219 obo:IAO_0000111 "alanine aminotransferase" ; obo:IAO_0000115 "A protein that is a translation product of the human GPT or GPT2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "alanine aminotransferase" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000050331 obo:IAO_0000111 "lactate dehydrogenase complex" ; obo:IAO_0000115 "A protein-containing complex that is composed of four subunits of L-lactate dehydrogenase, cytoplasmic." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "lactate dehydrogenase complex" ; rdfs:subClassOf obo:GO_0032991 . obo:PR_000050343 obo:IAO_0000111 "alkaline phosphatase (human)" ; obo:IAO_0000115 "A protein that is a translation product of any of the following alkaline phosphatase genes in human: ALPG (encoding the germinal form; GCAP), ALPP (encoding the placental form; PLAP), ALPI (encoding the intestinal form; IAP), and ALPL (encoding the tissue non-specific form; TNAP)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "alkaline phosphatase (human)" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000050353 obo:IAO_0000111 "aspartate aminotransferase (human)" ; obo:IAO_0000115 "A protein that is a translation product of any of the following genes in human: GOT1/GOT2." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "aspartate aminotransferase (human)" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000050469 obo:IAO_0000111 "hemoglobin A1c" ; obo:IAO_0000115 "A hemoglobin complex that is composed of at least one beta-N-1-deoxy fructosyl hemoglobin subunit, in which the glycan is attached to the N-terminal valine (after initiator methionine removal) of one or both beta subunits." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "hemoglobin A1c" ; rdfs:subClassOf obo:GO_0032991 . obo:REO_0000171 obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A reagent role inhering in a molecular entity intended to associate with some molecular target to serve as a proxy for the presence, abundance, or location of this target in a detection of molecular label assay." ; obo:IAO_0000117 "Group: OBI" ; obo:IAO_0000118 "molecular tracer role" ; obo:IAO_0000119 "OBI developer call, 3-12-12" ; obo:IAO_0000231 obo:OBI_0002743 ; a owl:Class ; rdfs:label "obsolete molecular label role" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:REO_0000280 obo:IAO_0000114 obo:IAO_0000122 ; obo:IAO_0000115 "A molecular reagent intended to associate with some molecular target to serve as a proxy for the presence, abundance, or location of this target in a detection of molecular label assay" ; obo:IAO_0000117 "Group: OBI" ; obo:IAO_0000118 "molecular tracer" ; obo:IAO_0000119 "OBI developer call, 3-12-12" ; obo:IAO_0000231 obo:OBI_0002744 ; a owl:Class ; rdfs:label "obsolete molecular label" ; rdfs:subClassOf oboInOwl:ObsoleteClass ; owl:deprecated true . obo:RO_0000052 obo:IAO_0000111 "inheres in"@en ; obo:IAO_0000112 "this fragility inheres in this vase"@en, "this red color inheres in this apple"@en ; obo:IAO_0000115 "a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence"@en ; obo:IAO_0000116 "A dependent inheres in its bearer at all times for which the dependent exists."@en ; obo:IAO_0000118 "inheres_in"@en ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:label "inheres in"@en ; owl:inverseOf obo:RO_0000053 . obo:RO_0000053 obo:IAO_0000111 "bearer of"@en ; obo:IAO_0000112 "this apple is bearer of this red color"@en, "this vase is bearer of this fragility"@en ; obo:IAO_0000115 "a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence"@en ; obo:IAO_0000116 "A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist."@en ; obo:IAO_0000118 "bearer_of"@en, "is bearer of"@en ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:label "bearer of"@en ; rdfs:range obo:BFO_0000020 . obo:RO_0000056 obo:IAO_0000111 "participates in"@en ; obo:IAO_0000112 "this blood clot participates in this blood coagulation"@en, "this input material (or this output material) participates in this process"@en, "this investigator participates in this investigation"@en ; obo:IAO_0000115 "a relation between a continuant and a process, in which the continuant is somehow involved in the process"@en ; obo:IAO_0000118 "participates_in"@en ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000002 ; rdfs:label "participates in"@en ; rdfs:range obo:BFO_0000003 ; owl:inverseOf obo:RO_0000057 . obo:RO_0000057 obo:IAO_0000111 "has participant"@en ; obo:IAO_0000112 "this blood coagulation has participant this blood clot"@en, "this investigation has participant this investigator"@en, "this process has participant this input material (or this output material)"@en ; obo:IAO_0000115 "a relation between a process and a continuant, in which the continuant is somehow involved in the process"@en ; obo:IAO_0000116 "Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time."@en ; obo:IAO_0000118 "has_participant"@en ; dc:source "http://www.obofoundry.org/ro/#OBO_REL:has_participant" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000003 ; rdfs:label "has participant"@en ; rdfs:range obo:BFO_0000002 . obo:RO_0000058 obo:IAO_0000112 "A journal article is an information artifact that inheres in some number of printed journals. For each copy of the printed journal there is some quality that carries the journal article, such as a pattern of ink. The journal article (a generically dependent continuant) is concretized as the quality (a specifically dependent continuant), and both depend on that copy of the printed journal (an independent continuant)."@en, "An investigator reads a protocol and forms a plan to carry out an assay. The plan is a realizable entity (a specifically dependent continuant) that concretizes the protocol (a generically dependent continuant), and both depend on the investigator (an independent continuant). The plan is then realized by the assay (a process)."@en ; obo:IAO_0000115 "A relationship between a generically dependent continuant and a specifically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. A generically dependent continuant may be concretized as multiple specifically dependent continuants."@en ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000031 ; rdfs:label "is concretized as"@en ; rdfs:range obo:BFO_0000020 ; owl:inverseOf obo:RO_0000059 . obo:RO_0000059 obo:IAO_0000112 "A journal article is an information artifact that inheres in some number of printed journals. For each copy of the printed journal there is some quality that carries the journal article, such as a pattern of ink. The quality (a specifically dependent continuant) concretizes the journal article (a generically dependent continuant), and both depend on that copy of the printed journal (an independent continuant)."@en, "An investigator reads a protocol and forms a plan to carry out an assay. The plan is a realizable entity (a specifically dependent continuant) that concretizes the protocol (a generically dependent continuant), and both depend on the investigator (an independent continuant). The plan is then realized by the assay (a process)."@en ; obo:IAO_0000115 "A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant."@en ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000020 ; rdfs:label "concretizes"@en ; rdfs:range obo:BFO_0000031 . obo:RO_0000079 obo:IAO_0000112 "this catalysis function is a function of this enzyme"@en ; obo:IAO_0000115 "a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence"@en ; obo:IAO_0000116 "A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists."@en ; obo:IAO_0000118 "function_of"@en, "is function of"@en ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000034 ; rdfs:label "function of"@en ; rdfs:subPropertyOf obo:RO_0000052 ; owl:inverseOf obo:RO_0000085 . obo:RO_0000080 obo:IAO_0000112 "this red color is a quality of this apple"@en ; obo:IAO_0000115 "a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence"@en ; obo:IAO_0000116 "A quality inheres in its bearer at all times for which the quality exists."@en ; obo:IAO_0000118 "is quality of"@en, "quality_of"@en ; a owl:ObjectProperty ; rdfs:label "quality of"@en ; rdfs:subPropertyOf obo:RO_0000052 ; owl:inverseOf obo:RO_0000086 . obo:RO_0000081 obo:IAO_0000112 "this investigator role is a role of this person"@en ; obo:IAO_0000115 "a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence"@en ; obo:IAO_0000116 "A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists."@en ; obo:IAO_0000118 "is role of"@en, "role_of"@en ; a owl:ObjectProperty ; rdfs:label "role of"@en ; rdfs:subPropertyOf obo:RO_0000052 ; owl:inverseOf obo:RO_0000087 . obo:RO_0000085 obo:IAO_0000112 "this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function)"@en ; obo:IAO_0000115 "a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence"@en ; obo:IAO_0000116 "A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists."@en ; obo:IAO_0000118 "has_function"@en ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "has function"@en ; rdfs:range obo:BFO_0000034 ; rdfs:subPropertyOf obo:RO_0000053 . obo:RO_0000086 obo:IAO_0000112 "this apple has quality this red color"@en ; obo:IAO_0000115 "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence"@en ; obo:IAO_0000116 "A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist."@en ; obo:IAO_0000118 "has_quality"@en ; a owl:ObjectProperty ; rdfs:label "has quality"@en ; rdfs:range obo:BFO_0000019 ; rdfs:subPropertyOf obo:RO_0000053 . obo:RO_0000087 obo:IAO_0000112 "this person has role this investigator role (more colloquially: this person has this role of investigator)"@en ; obo:IAO_0000115 "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence"@en ; obo:IAO_0000116 "A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists."@en ; obo:IAO_0000118 "has_role"@en ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "has role"@en ; rdfs:range obo:BFO_0000023 ; rdfs:subPropertyOf obo:RO_0000053 . obo:RO_0000091 obo:IAO_0000115 "a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence"@en ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "has disposition"@en ; rdfs:range obo:BFO_0000016 ; rdfs:subPropertyOf obo:RO_0000053 ; owl:inverseOf obo:RO_0000092 . obo:RO_0000092 a owl:ObjectProperty ; rdfs:label "disposition of"@en ; rdfs:subPropertyOf obo:RO_0000052 . obo:RO_0001000 obo:IAO_0000111 "derives from" ; obo:IAO_0000112 "this cell derives from this parent cell (cell division)"@en, "this nucleus derives from this parent nucleus (nuclear division)"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity"@en ; obo:IAO_0000116 "This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops from'."@en ; obo:IAO_0000118 "derives_from"@en ; obo:IAO_0000412 ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "derives from"@en ; rdfs:range obo:BFO_0000004 ; rdfs:subPropertyOf owl:topObjectProperty ; owl:inverseOf obo:RO_0001001 . obo:RO_0001001 obo:IAO_0000112 "this parent cell derives into this cell (cell division)"@en, "this parent nucleus derives into this nucleus (nuclear division)"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity"@en ; obo:IAO_0000116 "This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops into'. To avoid making statements about a future that may not come to pass, it is often better to use the backward-looking 'derives from' rather than the forward-looking 'derives into'."@en ; obo:IAO_0000118 "derives_into"@en ; a owl:ObjectProperty ; rdfs:label "derives into"@en . obo:RO_0001015 obo:IAO_0000111 "is location of"@en ; obo:IAO_0000112 "my head is the location of my brain"@en, "this cage is the location of this rat"@en ; obo:IAO_0000115 "a relation between two independent continuants, the location and the target, in which the target is entirely within the location"@en ; obo:IAO_0000116 "Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime"@en ; obo:IAO_0000118 "location_of"@en ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "location of"@en ; owl:inverseOf obo:RO_0001025 . obo:RO_0001025 obo:IAO_0000111 "located in"@en ; obo:IAO_0000112 "my brain is located in my head"@en, "this rat is located in this cage"@en ; obo:IAO_0000115 "a relation between two independent continuants, the target and the location, in which the target is entirely within the location"@en ; obo:IAO_0000116 "Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus"@en, "Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime"@en ; obo:IAO_0000118 "located_in"@en ; obo:RO_0001900 obo:RO_0001901 ; dc:source "http://www.obofoundry.org/ro/#OBO_REL:located_in" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:domain obo:BFO_0000004, [ a owl:Class ; owl:intersectionOf (obo:BFO_0000004 [ a owl:Class ; owl:complementOf obo:BFO_0000006 ] ) ] ; rdfs:label "located in"@en ; rdfs:range obo:BFO_0000004, [ a owl:Class ; owl:intersectionOf (obo:BFO_0000004 [ a owl:Class ; owl:complementOf obo:BFO_0000006 ] ) ] . obo:RO_0001900 obo:IAO_0000115 "An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context." ; a owl:AnnotationProperty ; rdfs:label "temporal interpretation"@en ; rdfs:seeAlso "https://oborel.github.io/obo-relations/temporal-semantics/"^^xsd:anyURI . obo:RO_0001901 obo:IAO_0000115 """ ## Elucidation This is used when the statement/axiom is assumed to hold true 'eternally' ## How to interpret (informal) First the \"atemporal\" FOL is derived from the OWL using the standard interpretation. This axiom is temporalized by embedding the axiom within a for-all-times quantified sentence. The t argument is added to all instantiation predicates and predicates that use this relation. ## Example Class: nucleus SubClassOf: part_of some cell forall t : forall n : instance_of(n,Nucleus,t) implies exists c : instance_of(c,Cell,t) part_of(n,c,t) ## Notes This interpretation is *not* the same as an at-all-times relation """ ; a owl:NamedIndividual ; rdfs:label "axiom holds for all times"@en . obo:RO_0001902 obo:IAO_0000115 """ ## Elucidation This is used when the first-order logic form of the relation is binary, and takes no temporal argument. ## Example: Class: limb SubClassOf: develops_from some lateral-plate-mesoderm forall t, t2: forall x : instance_of(x,Limb,t) implies exists y : instance_of(y,LPM,t2) develops_from(x,y) """ ; a owl:NamedIndividual ; rdfs:label "relation has no temporal argument"@en . obo:RO_0002000 obo:IAO_0000112 "the surface of my skin is a 2D boundary of my body"@en ; obo:IAO_0000115 "a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity"@en ; obo:IAO_0000116 "A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts."@en, "Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape."@en ; obo:IAO_0000118 "2D_boundary_of"@en, "boundary of"@en, "is 2D boundary of"@en, "is boundary of"@en ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:label "2D boundary of"@en ; owl:inverseOf obo:RO_0002002 . obo:RO_0002002 obo:IAO_0000112 "my body has 2D boundary the surface of my skin"@en ; obo:IAO_0000115 "a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity"@en ; obo:IAO_0000116 "A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts."@en, "Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape."@en ; obo:IAO_0000118 "has boundary"@en, "has_2D_boundary"@en ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "has 2D boundary"@en ; rdfs:range obo:BFO_0000141 . obo:RO_0002087 obo:IAO_0000117 "David Osumi-Sutherland" ; obo:IAO_0000118 "starts_at_end_of" ; a owl:ObjectProperty ; rdfs:comment "X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)"@en ; rdfs:label "immediately preceded by"@en ; rdfs:subPropertyOf obo:BFO_0000062 ; owl:inverseOf obo:RO_0002090 . obo:RO_0002090 obo:IAO_0000117 "David Osumi-Sutherland" ; obo:IAO_0000118 "ends_at_start_of", "meets" ; a owl:ObjectProperty ; rdfs:comment "X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)"@en ; rdfs:label "immediately precedes"@en ; rdfs:subPropertyOf obo:BFO_0000063 . obo:RO_0002180 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." ; obo:IAO_0000116 "The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity." ; obo:IAO_0000232 "For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit."@en ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:label "has component"@en ; rdfs:seeAlso ; rdfs:subPropertyOf obo:BFO_0000051 . obo:RO_0002215 obo:IAO_0000115 "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process." ; obo:IAO_0000118 "has function realized in" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "capable of" ; rdfs:range obo:BFO_0000015 . obo:RO_0002219 obo:IAO_0000111 "surrounded by" ; obo:IAO_0000115 "x surrounded_by y if and only if x is adjacent to y and for every region r that is adjacent to x, r overlaps y" ; obo:IAO_0000412 ; a owl:ObjectProperty ; rdfs:label "surrounded by"@en ; rdfs:subPropertyOf obo:RO_0002220 . obo:RO_0002220 a owl:ObjectProperty ; rdfs:label "adjacent to" . obo:RO_0002222 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000116 "move to BFO?" ; obo:IAO_0000119 "Allen" ; a owl:ObjectProperty ; rdfs:comment "A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations." ; rdfs:label "temporal relation"@en ; rdfs:range obo:BFO_0000003 . obo:RO_0002223 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "inverse of starts with" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "Allen" ; a owl:ObjectProperty ; rdfs:label "starts"@en ; rdfs:subPropertyOf obo:BFO_0000050, obo:RO_0002222 . obo:RO_0002350 obo:IAO_0000112 "An organism that is a member of a population of organisms" ; obo:IAO_0000115 "is member of is a mereological relation between a item and a collection." ; obo:IAO_0000118 "is member of", "member part of" ; obo:IAO_0000119 "SIO" ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:label "member of"@en ; rdfs:subPropertyOf obo:BFO_0000050 ; owl:inverseOf obo:RO_0002351 . obo:RO_0002351 obo:IAO_0000115 "has member is a mereological relation between a collection and an item." ; obo:IAO_0000119 "SIO" ; obo:RO_0001900 obo:RO_0001901 ; a owl:IrreflexiveProperty, owl:ObjectProperty ; rdfs:label "has member"@en ; rdfs:subPropertyOf obo:BFO_0000051 . obo:SO_0000001 obo:IAO_0000111 "region" ; obo:IAO_0000115 "A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino acids." ; obo:IAO_0000118 "primary structure of sequence macromolecule", "sequence" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "region" ; rdfs:subClassOf obo:BFO_0000031 . obo:SO_0000104 obo:IAO_0000111 "polypeptide" ; obo:IAO_0000115 "A sequence of amino acids linked by peptide bonds which may lack appreciable tertiary structure and may not be liable to irreversible denaturation." ; obo:IAO_0000118 "polypeptide sequence" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "polypeptide" ; rdfs:subClassOf obo:SO_0000001 . obo:SO_0000148 obo:IAO_0000111 "supercontig" ; obo:IAO_0000115 "One or more contigs that have been ordered and oriented using end-read information. Contains gaps that are filled with N's." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "supercontig" ; rdfs:subClassOf obo:SO_0000353 . obo:SO_0000149 obo:IAO_0000111 "contig" ; obo:IAO_0000115 "A contiguous sequence derived from sequence assembly. Has no gaps, but may contain N's from unavailable bases." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "contig" ; rdfs:subClassOf obo:SO_0000353 . obo:SO_0000235 obo:IAO_0000111 "TF_binding_site" ; obo:IAO_0000115 "A DNA site where a transcription factor binds." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "TF_binding_site" ; rdfs:subClassOf obo:SO_0005836 . obo:SO_0000276 obo:IAO_0000111 "miRNA" ; obo:IAO_0000115 "Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene (or the product of other non coding RNA genes. Micro RNAs are produced from precursor molecules (SO:0001244) that can form local hairpin structures, which ordinarily are processed (usually via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "miRNA" ; rdfs:subClassOf obo:SO_0000001 . obo:SO_0000353 obo:IAO_0000111 "sequence_assembly" ; obo:IAO_0000115 "A sequence of nucleotides that has been algorithmically derived from an alignment of two or more different sequences." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "sequence_assembly" ; rdfs:subClassOf obo:SO_0001248 . obo:SO_0000988 obo:IAO_0000111 "circular" ; obo:IAO_0000115 "A quality of a nucleotide polymer that has no terminal nucleotide residues." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "circular" ; rdfs:subClassOf obo:PATO_0001241 . obo:SO_0001248 obo:IAO_0000111 "assembly" ; obo:IAO_0000115 "A region of the genome of known length that is composed by ordering and aligning two or more different regions." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "assembly" ; rdfs:subClassOf obo:SO_0001410 . obo:SO_0001410 obo:IAO_0000111 "experimental_feature" ; obo:IAO_0000115 "A region which is the result of some arbitrary experimental procedure. The procedure may be carried out with biological material or inside a computer." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "experimental_feature" ; rdfs:subClassOf obo:SO_0000001 . obo:SO_0005836 obo:IAO_0000111 "regulatory_region" ; obo:IAO_0000115 "A region of sequence that is involved in the control of a biological process." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "regulatory_region" ; rdfs:subClassOf obo:SO_0000001 . obo:UBERON_0000002 obo:IAO_0000111 "uterine cervix" ; obo:IAO_0000115 "Lower, narrow portion of the uterus where it joins with the top end of the vagina." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "uterine cervix" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000007 obo:IAO_0000111 "pituitary gland" ; obo:IAO_0000115 "The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands [GO]. An endocrine gland located ventral to the diencephalon and derived from mixed neuroectodermal and non neuroectodermal origin [ZFIN]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "pituitary gland" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000010 obo:IAO_0000111 "peripheral nervous system" ; obo:IAO_0000115 "A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "peripheral nervous system" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000029 obo:IAO_0000111 "lymph node" ; obo:IAO_0000115 "Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "lymph node" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000057 obo:IAO_0000111 "urethra" ; obo:IAO_0000115 "The fibromuscular tubular canal through which urine is discharged from the bladder to the exterior via the external urinary meatus; in males, the urethra is joined by the ejaculatory ducts and serves as a passageway for semen during ejaculation, as well as a canal for urine during voiding; in females, the urethra is shorter and emerges above the vaginal opening." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "urethra" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000105 obo:IAO_0000111 "life cycle stage" ; obo:IAO_0000115 "A spatiotemporal region encompassing some part of the life cycle of an organism." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "life cycle stage" ; rdfs:subClassOf obo:GO_0008150 . obo:UBERON_0000165 obo:IAO_0000111 "mouth" ; obo:IAO_0000115 "The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mouth" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000173 obo:IAO_0000111 "amniotic fluid" ; obo:IAO_0000115 "Amniotic fluid is a bodily fluid consisting of watery liquid surrounding and cushioning a growing fetus within the amnion. It allows the fetus to move freely without the walls of the uterus being too tight against its body. Buoyancy is also provided. The composition of the fluid changes over the course of gestation. Initially, amniotic fluid is similar to maternal plasma, mainly water with electrolytes. As the fetus develops, proteins, carbohydrates, lipids, phospholipids originating from the lungs, fetal cells, and urea are deposited in the fluid." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "amniotic fluid" ; rdfs:subClassOf obo:UBERON_0000463 . obo:UBERON_0000178 obo:IAO_0000111 "blood" ; obo:IAO_0000115 "A fluid that is composed of blood plasma and erythrocytes." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "blood" ; rdfs:subClassOf obo:UBERON_0006314 . obo:UBERON_0000305 obo:IAO_0000111 "amnion" ; obo:IAO_0000115 "The thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "amnion" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000310 obo:IAO_0000111 "breast" ; obo:IAO_0000115 "The upper ventral region of the torso of an organism." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "breast" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000316 obo:IAO_0000111 "cervical mucus" ; obo:IAO_0000115 "A substance produced by the cervix and endocervical glands[BTO]. Thick acidic mucus that blocks the cervical os after mestruation[WP]. This 'infertile' mucus blocks spermatozoa from entering the uterus." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cervical mucus" ; rdfs:subClassOf obo:UBERON_0006314 . obo:UBERON_0000341 obo:IAO_0000111 "throat" ; obo:IAO_0000115 "In anatomy, the throat is the anterior part of the neck, in front of the vertebral column. It consists of the pharynx and larynx. An important feature of the throat is the epiglottis, a flap which separates the esophagus from the trachea and prevents inhalation of food or drink. The throat contains various blood vessels, various pharyngeal muscles, the trachea (windpipe) and the esophagus. The hyoid bone and the clavicle are the only bones located in the throat of mammals. It is sometimes considered a synonym for fauces. [WP,unvetted]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "throat" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000362 obo:IAO_0000111 "renal medulla" ; obo:IAO_0000115 "The inner portion of the kidney consisting of the renal pyramids." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "renal medulla" ; rdfs:subClassOf obo:UBERON_0000481 . obo:UBERON_0000463 obo:IAO_0000111 "organism substance" ; obo:IAO_0000115 "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "organism substance" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000465 obo:IAO_0000111 "material anatomical entity" ; obo:IAO_0000115 "Anatomical entity that has mass." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "material anatomical entity" ; rdfs:subClassOf obo:BFO_0000040 . obo:UBERON_0000473 obo:IAO_0000111 "testis" ; obo:IAO_0000115 "A gonad of a male animal. A gonad produces and releases sperm." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "testis" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000477 obo:IAO_0000111 "anatomical cluster" ; obo:IAO_0000115 "Anatomical group whose component anatomical structures lie in close proximity to each other." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "anatomical cluster" ; rdfs:subClassOf obo:BFO_0000040 . obo:UBERON_0000479 obo:IAO_0000111 "tissue" ; obo:IAO_0000115 "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "tissue" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000481 obo:IAO_0000111 "multi-tissue structure" ; obo:IAO_0000115 "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "multi-tissue structure" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000483 obo:IAO_0000111 "epithelium" ; obo:IAO_0000115 "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "epithelium" ; rdfs:subClassOf obo:UBERON_0000479 . obo:UBERON_0000945 obo:IAO_0000111 "stomach" ; obo:IAO_0000115 "An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "stomach" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000947 obo:IAO_0000111 "aorta" ; obo:IAO_0000115 "The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "aorta" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000948 obo:IAO_0000111 "heart" ; obo:IAO_0000115 "A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "heart" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000955 obo:IAO_0000111 "brain" ; obo:IAO_0000115 "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "brain" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000956 obo:IAO_0000111 "cerebral cortex" ; obo:IAO_0000115 "The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cerebral cortex" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000970 obo:IAO_0000111 "eye" ; obo:IAO_0000115 "An organ that detects light." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "eye" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000978 obo:IAO_0000111 "leg" ; obo:IAO_0000115 "The portion of the hindlimb that contains both the stylopod and zeugopod." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "leg" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000992 obo:IAO_0000111 "ovary" ; obo:IAO_0000115 "The gonad of a female organism which contains germ cells." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ovary" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000995 obo:IAO_0000111 "uterus" ; obo:IAO_0000115 "The female muscular organ of gestation in which the developing embryo or fetus is nourished until birth." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "uterus" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0000996 obo:IAO_0000111 "vagina" ; obo:IAO_0000115 "A fibromuscular tubular tract leading from the uterus to the exterior of the body in female placental mammals and marsupials, or to the cloaca in female birds, monotremes, and some reptiles[WP]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "vagina" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001003 obo:IAO_0000111 "skin epidermis" ; obo:IAO_0000115 "The outer epithelial layer of the skin that is superficial to the dermis." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "skin epidermis" ; rdfs:subClassOf obo:UBERON_0000483 . obo:UBERON_0001004 obo:IAO_0000111 "respiratory system" ; obo:IAO_0000115 "Functional system which consists of structures involved in respiration." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "respiratory system" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001013 obo:IAO_0000111 "adipose tissue" ; obo:IAO_0000115 "Portion of connective tissue composed of adipocytes enmeshed in areolar tissue." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "adipose tissue" ; rdfs:subClassOf obo:UBERON_0000479 . obo:UBERON_0001037 obo:IAO_0000111 "strand of hair" ; obo:IAO_0000115 "A filament, mostly protein, that grows from follicles found in the dermis[WP]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "strand of hair" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001052 obo:IAO_0000111 "rectum" ; obo:IAO_0000115 "The terminal portion of the intestinal tube, terminating with the anus." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "rectum" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001087 obo:IAO_0000111 "pleural fluid" ; obo:IAO_0000115 "Transudate contained in the pleural cavity." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "pleural fluid" ; rdfs:subClassOf obo:UBERON_0006314 . obo:UBERON_0001088 obo:IAO_0000111 "urine" ; obo:IAO_0000115 "Excretion that is the output of a kidney." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "urine" ; rdfs:subClassOf obo:UBERON_0000463 . obo:UBERON_0001089 obo:IAO_0000111 "sweat" ; obo:IAO_0000115 "Secretion produced by a sweat gland." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "sweat" ; rdfs:subClassOf obo:UBERON_0006314 . obo:UBERON_0001090 obo:IAO_0000111 "synovial fluid" ; obo:IAO_0000115 "Joint fluid is a transudate of plasma that is actively secreted by synovial cells." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "synovial fluid" ; rdfs:subClassOf obo:UBERON_0006314 . obo:UBERON_0001103 obo:IAO_0000111 "diaphragm" ; obo:IAO_0000115 "A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "diaphragm" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001134 obo:IAO_0000111 "skeletal muscle tissue" ; obo:IAO_0000115 "Muscle tissue that consists primarily of skeletal muscle fibers." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "skeletal muscle tissue" ; rdfs:subClassOf obo:UBERON_0000479 . obo:UBERON_0001155 obo:IAO_0000111 "colon" ; obo:IAO_0000115 "A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "colon" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001159 obo:IAO_0000111 "sigmoid colon" ; obo:IAO_0000115 "The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "sigmoid colon" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001225 obo:IAO_0000111 "cortex of kidney" ; obo:IAO_0000115 "Outer cortical portion of the kidney, between the renal capsule and the renal medulla." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cortex of kidney" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001255 obo:IAO_0000111 "urinary bladder" ; obo:IAO_0000115 "Distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "urinary bladder" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001264 obo:IAO_0000111 "pancreas" ; obo:IAO_0000115 "An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "pancreas" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001268 obo:IAO_0000111 "peritoneal fluid" ; obo:IAO_0000115 "Transudate contained in the peritoneal cavity." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "peritoneal fluid" ; rdfs:subClassOf obo:UBERON_0006314 . obo:UBERON_0001323 obo:IAO_0000111 "tibial nerve" ; obo:IAO_0000115 "The tibial nerve is a branch of the sciatic nerve. The tibial nerve passes through the popliteal fossa to pass below the arch of soleus. In the popliteal fossa the nerve gives off branches to gastrocnemius, popliteus, soleus and plantaris muscles, an articular branch to the knee joint, and a cutaneous branch that will become the sural nerve. The sural nerve is joined by fibres from the common peroneal nerve and runs down the calf to supply the lateral side of the foot. Below the soleus muscle the nerve lies close to the tibia and supplies the tibialis posterior, the flexor digitorum longus and the flexor hallucis longus. The nerve passes into the foot running posterior to the medial malleolus. Here it is bound down by the flexor retinaculum in company with the posterior tibial artery. [WP,unvetted]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "tibial nerve" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001359 obo:IAO_0000111 "cerebrospinal fluid" ; obo:IAO_0000115 "A clear, colorless, bodily fluid, that occupies the subarachnoid space and the ventricular system around and inside the brain and spinal cord." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cerebrospinal fluid" ; rdfs:subClassOf obo:UBERON_0006314 . obo:UBERON_0001460 obo:IAO_0000111 "arm" ; obo:IAO_0000115 "The part of the forelimb extending from the shoulder to the autopod[cjm]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "arm" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001485 obo:IAO_0000111 "knee joint" ; obo:IAO_0000115 "The knee joint joins the thigh with the leg and consists of two articulations: one between the femur and tibia, and one between the femur and patella. It is the largest and most complicated joint in the human body. The knee is a mobile trocho-ginglymus (i.e. a pivotal hinge joint), which permits flexion and extension as well as a slight medial and lateral rotation[WP,unvetted]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "knee joint" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001488 obo:IAO_0000111 "ankle joint" ; obo:IAO_0000115 "A joint that connects the hindlimb autopod and zeugopod skeletons." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ankle joint" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001530 obo:IAO_0000111 "common carotid artery plus branches" ; obo:IAO_0000115 "A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "common carotid artery plus branches" ; rdfs:subClassOf obo:UBERON_0001637 . obo:UBERON_0001555 obo:IAO_0000111 "digestive tract" ; obo:IAO_0000115 "A tube extending from the mouth to the anus." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "digestive tract" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001557 obo:IAO_0000111 "upper respiratory tract" ; obo:IAO_0000115 "The segment of the respiratory tract that starts proximally with the nose and ends distally with the cricoid cartilage, before continuing to the trachea." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "upper respiratory tract" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001558 obo:IAO_0000111 "lower respiratory tract" ; obo:IAO_0000115 "The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "lower respiratory tract" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001567 obo:IAO_0000111 "cheek" ; obo:IAO_0000115 "A fleshy subdivision of one side of the face bounded by an eye, ear and the nose." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cheek" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001577 obo:IAO_0000111 "facial muscle" ; obo:IAO_0000115 "A muscle innervated by a facial nerve." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "facial muscle" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001621 obo:IAO_0000111 "coronary artery" ; obo:IAO_0000115 "An artery that supplies the myocardium." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "coronary artery" ; rdfs:subClassOf obo:UBERON_0001637 . obo:UBERON_0001637 obo:IAO_0000111 "artery" ; obo:IAO_0000115 "An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "artery" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001638 obo:IAO_0000111 "vein" ; obo:IAO_0000115 "Any of the tubular branching vessels that carry blood from the capillaries toward the heart." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "vein" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001723 obo:IAO_0000111 "tongue" ; obo:IAO_0000115 "A muscular organ in the floor of the mouth." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "tongue" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001728 obo:IAO_0000111 "nasopharynx" ; obo:IAO_0000115 "The section of the pharynx that lies above the soft palate." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "nasopharynx" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001729 obo:IAO_0000111 "oropharynx" ; obo:IAO_0000115 "The portion of the pharynx that lies between the soft palate and the upper edge of the epiglottis." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "oropharynx" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001797 obo:IAO_0000111 "vitreous humor" ; obo:IAO_0000115 "A transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "vitreous humor" ; rdfs:subClassOf obo:UBERON_0000463 . obo:UBERON_0001811 obo:IAO_0000111 "conjunctiva" ; obo:IAO_0000115 "The mucous membrane that lines the inner surface of the eyelids and the front of the eyeball." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "conjunctiva" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001826 obo:IAO_0000111 "nasal cavity mucosa" ; obo:IAO_0000115 "The mucous membrane that lines the nasal cavity[MP]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "nasal cavity mucosa" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001830 obo:IAO_0000111 "minor salivary gland" ; obo:IAO_0000115 "One of the smaller, largely mucus-secreting, exocrine glands of the oral cavity, consisting of the labial, buccal, molar, lingual, and palatine glands[MP]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "minor salivary gland" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001836 obo:IAO_0000111 "saliva" ; obo:IAO_0000115 "A fluid produced in the oral cavity by salivary glands, typically used in predigestion, but also in other functions." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "saliva" ; rdfs:subClassOf obo:UBERON_0000463 . obo:UBERON_0001873 obo:IAO_0000111 "caudate nucleus" ; obo:IAO_0000115 "Subcortical nucleus of telecephalic origin consisting of an elongated gray mass lying lateral to and bordering the lateral ventricle. It is divided into a head, body and tail in some species." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "caudate nucleus" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001874 obo:IAO_0000111 "putamen" ; obo:IAO_0000115 "Subcortical nucleus of telencephalic , which together with the caudate nucleus, forms the striatum. The putamen lies lateral to the internal capsule and medial to the external medullary lamina, and is separated from the caudate nucleus by the fibers of the internal capsule for most of its length, except at its anterior portion." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "putamen" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001893 obo:IAO_0000111 "telencephalon" ; obo:IAO_0000115 "Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "telencephalon" ; rdfs:subClassOf obo:UBERON_0000481 . obo:UBERON_0001913 obo:IAO_0000111 "milk" ; obo:IAO_0000115 "An emulsion of fat globules within a fluid that is secreted by the mammary gland during lactation." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "milk" ; rdfs:subClassOf obo:UBERON_0006314 . obo:UBERON_0001968 obo:IAO_0000111 "semen" ; obo:IAO_0000115 "Organism substance that is composed of sperm cells suspended in seminal fluid." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "semen" ; rdfs:subClassOf obo:UBERON_0000463 . obo:UBERON_0001970 obo:IAO_0000111 "bile" ; obo:IAO_0000115 "Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "bile" ; rdfs:subClassOf obo:UBERON_0006314 . obo:UBERON_0001987 obo:IAO_0000111 "placenta" ; obo:IAO_0000115 "Organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin[GO]. The fetal portion of the placenta is known as the villous chorion. The maternal portion is known as the decidua basalis. The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "placenta" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0001988 obo:IAO_0000111 "feces" ; obo:IAO_0000115 "Portion of semisolid bodily waste discharged through the anus[MW,modified]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "feces" ; rdfs:subClassOf obo:UBERON_0000463 . obo:UBERON_0002032 obo:IAO_0000111 "areola" ; obo:IAO_0000115 "Subdivision of breast which consists of skin, connective tissue and smooth muscle bundle and modified sebaceous glands and which surrounds the nipple." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "areola" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002037 obo:IAO_0000111 "cerebellum" ; obo:IAO_0000115 "Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cerebellum" ; rdfs:subClassOf obo:UBERON_0000481 . obo:UBERON_0002046 obo:IAO_0000111 "thyroid gland" ; obo:IAO_0000115 "A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "thyroid gland" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002048 obo:IAO_0000111 "lung" ; obo:IAO_0000115 "Respiration organ that develops as an outpocketing of the esophagus." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "lung" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002067 obo:IAO_0000111 "dermis" ; obo:IAO_0000115 "The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "dermis" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002072 obo:IAO_0000111 "hypodermis" ; obo:IAO_0000115 "Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "hypodermis" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002097 obo:IAO_0000111 "skin of body" ; obo:IAO_0000115 "The organ covering the body that consists of the dermis and epidermis." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "skin of body" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002106 obo:IAO_0000111 "spleen" ; obo:IAO_0000115 "The organ that functions to filter blood and to store red corpuscles and platelets." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "spleen" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002107 obo:IAO_0000111 "liver" ; obo:IAO_0000115 "An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "liver" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002116 obo:IAO_0000111 "ileum" ; obo:IAO_0000115 "The portion of the small intestine that extends from the jejunum to the colon." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "ileum" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002199 obo:IAO_0000111 "integument" ; obo:IAO_0000115 "The dermis, epidermis and hypodermis." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "integument" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002358 obo:IAO_0000111 "peritoneum" ; obo:IAO_0000115 "A serous membrane that lines the peritoneal cavity[VHOG,modified]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "peritoneum" ; rdfs:subClassOf obo:UBERON_0000481 . obo:UBERON_0002367 obo:IAO_0000111 "prostate gland" ; obo:IAO_0000115 "The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "prostate gland" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002369 obo:IAO_0000111 "adrenal gland" ; obo:IAO_0000115 "Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "adrenal gland" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002371 obo:IAO_0000111 "bone marrow" ; obo:IAO_0000115 "The soft tissue that fills the cavities of bones." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "bone marrow" ; rdfs:subClassOf obo:UBERON_0000479 . obo:UBERON_0002386 obo:IAO_0000111 "forelimb zeugopod" ; obo:IAO_0000115 "The middle limb segment of the pectoral free limb, between the autopod and stylopod segments. Includes as parts the forelimb zeugopodial skeleton, which includes as parts the radius and ulna, or their cartilage precursors, or evolutionary variants." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "forelimb zeugopod" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002389 obo:IAO_0000111 "manual digit" ; obo:IAO_0000115 "A digit that is part of a manus (hand)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "manual digit" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002391 obo:IAO_0000111 "lymph" ; obo:IAO_0000115 "Lymph is the fluid that is formed when interstitial fluid enters the conduits of the lymphatic system through lymph capillaries[WP]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "lymph" ; rdfs:subClassOf obo:UBERON_0006314 . obo:UBERON_0002409 obo:IAO_0000111 "pericardial fluid" ; obo:IAO_0000115 "Transudate contained in the pericardial cavity.[FMA]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "pericardial fluid" ; rdfs:subClassOf obo:UBERON_0006314 . obo:UBERON_0002415 obo:IAO_0000111 "tail" ; obo:IAO_0000115 "An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "tail" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002465 obo:IAO_0000111 "lymphoid system" ; obo:IAO_0000115 "The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system[WP]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "lymphoid system" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002469 obo:IAO_0000111 "esophagus mucosa" ; obo:IAO_0000115 "A mucosa that is part of a esophagus [Automatically generated definition]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "esophagus mucosa" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002812 obo:IAO_0000111 "left cerebral hemisphere" ; obo:IAO_0000115 "A cerebral hemisphere that is in the left side of a brain." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "left cerebral hemisphere" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0002813 obo:IAO_0000111 "right cerebral hemisphere" ; obo:IAO_0000115 "A cerebral hemisphere that is in the right side of a brain." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "right cerebral hemisphere" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0003126 obo:IAO_0000111 "trachea" ; obo:IAO_0000115 "The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "trachea" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0003128 obo:IAO_0000111 "cranium" ; obo:IAO_0000115 "Upper portion of the skull that excludes the mandible (when present in the organism)." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "cranium" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0003688 obo:IAO_0000111 "omentum" ; obo:IAO_0000115 "A fold of peritoneum originating at the stomach and supporting the viscera." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "omentum" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0004648 obo:IAO_0000111 "esophagus muscularis mucosa" ; obo:IAO_0000115 "A muscularis mucosa that is part of a esophagus." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "esophagus muscularis mucosa" ; rdfs:subClassOf obo:UBERON_0000479 . obo:UBERON_0005022 obo:IAO_0000111 "mucosa of nasopharynx" ; obo:IAO_0000115 "A mucosa that is part of a nasopharynx [Automatically generated definition]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mucosa of nasopharynx" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0005023 obo:IAO_0000111 "mucosa of oropharynx" ; obo:IAO_0000115 "A mucosa that is part of a oropharynx [Automatically generated definition]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mucosa of oropharynx" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0005921 obo:IAO_0000111 "middle nasal concha" ; obo:IAO_0000115 "The medial surface of the labyrinth of ethmoid consists of a thin lamella, which descends from the under surface of the cribriform plate, and ends below in a free, convoluted margin, the middle nasal concha. It is rough, and marked above by numerous grooves, directed nearly vertically downward from the cribriform plate; they lodge branches of the olfactory nerves, which are distributed to the mucous membrane covering the superior nasal concha." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "middle nasal concha" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0006314 obo:IAO_0000111 "bodily fluid" ; obo:IAO_0000115 "Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "bodily fluid" ; rdfs:subClassOf obo:UBERON_0000463 . obo:UBERON_0006538 obo:IAO_0000111 "respiratory system fluid/secretion" ; obo:IAO_0000115 "A portion of organism substance that secreted_by a respiratory system." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "respiratory system fluid/secretion" ; rdfs:subClassOf obo:UBERON_0000463 . obo:UBERON_0006618 obo:IAO_0000111 "atrium auricular region" ; obo:IAO_0000115 "A small conical pouch projections located on the upper anterior portion of each atrium of the heart." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "atrium auricular region" ; rdfs:subClassOf obo:UBERON_0000481 . obo:UBERON_0006911 obo:IAO_0000111 "digestive system secreted substance" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "digestive system secreted substance" ; rdfs:subClassOf obo:UBERON_0000463 . obo:UBERON_0007106 obo:IAO_0000111 "chorionic villus" ; obo:IAO_0000115 "One of the minute vascular projections of the fetal chorion that combines with maternal uterine tissue to form the placenta." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "chorionic villus" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0007109 obo:IAO_0000111 "meconium" ; obo:IAO_0000115 "A dark greenish mass that accumulates in the bowel during fetal life and is discharged shortly after birth." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "meconium" ; rdfs:subClassOf obo:UBERON_0001988 . obo:UBERON_0007311 obo:IAO_0000111 "sputum" ; obo:IAO_0000115 "Matter ejected from the lungs, bronchi, and trachea, through the mouth." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "sputum" ; rdfs:subClassOf obo:UBERON_0006538 . obo:UBERON_0007610 obo:IAO_0000111 "tibial artery" ; obo:IAO_0000115 "The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and pes. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "tibial artery" ; rdfs:subClassOf obo:UBERON_0001637 . obo:UBERON_0007650 obo:IAO_0000111 "esophagogastric junction" ; obo:IAO_0000115 "The junction between the esophagus and the stomach epithelium." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "esophagogastric junction" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0008188 obo:IAO_0000111 "tendon of biceps brachii" ; obo:IAO_0000115 "A tendon that attaches_to a biceps brachii." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "tendon of biceps brachii" ; rdfs:subClassOf obo:UBERON_0000479 . obo:UBERON_0010414 obo:IAO_0000111 "omental fat pad" ; obo:IAO_0000115 "Encapsulated adipose tissue associated with the fold of peritoneal tissue that extends from the stomach to the posterior abdominal wall after associating with the transverse colon." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "omental fat pad" ; rdfs:subClassOf obo:UBERON_0001013 . obo:UBERON_0011011 obo:IAO_0000111 "brachioradialis" ; obo:IAO_0000115 "Brachioradialis is a muscle of the forearm that acts to flex the forearm at the elbow. It is also capable of both pronation and supination, depending on the position of the forearm. It is attached to the distal styloid process of the radius by way of the brachioradialis tendon, and to the lateral supracondylar ridge of the humerus." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "brachioradialis" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_0012168 obo:IAO_0000111 "umbilical cord blood" ; obo:IAO_0000115 "Blood that remains in the placenta and in the attached umbilical cord after childbirth[WP]." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "umbilical cord blood" ; rdfs:subClassOf obo:UBERON_0013755 . obo:UBERON_0013755 obo:IAO_0000111 "arterial blood" ; obo:IAO_0000115 "A blood that is part of a artery." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "arterial blood" ; rdfs:subClassOf obo:UBERON_0000178 . obo:UBERON_0013756 obo:IAO_0000111 "venous blood" ; obo:IAO_0000115 "A blood that is part of a vein." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "venous blood" ; rdfs:subClassOf obo:UBERON_0000178 . obo:UBERON_0013757 obo:IAO_0000111 "capillary blood" ; obo:IAO_0000115 "A blood that is part of a capillary." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "capillary blood" ; rdfs:subClassOf obo:UBERON_0000178 . obo:UBERON_0036149 obo:IAO_0000111 "suprapubic skin" ; obo:IAO_0000115 "Area of skin in the hypoastric region of the abdomen." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "suprapubic skin" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_3000016 obo:IAO_0000111 "anterior nasal wall" ; obo:IAO_0000115 "Paired, vertical, and relatively straight plates that form the anterior limit of the nasal capsule." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "anterior nasal wall" ; rdfs:subClassOf obo:UBERON_0000465 . obo:UBERON_8470000 obo:IAO_0000111 "placental blood" ; obo:IAO_0000115 "Blood located in the placenta." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "placental blood" ; rdfs:subClassOf obo:UBERON_0000178 . obo:UO_0000001 obo:IAO_0000111 "length unit" ; obo:IAO_0000115 "A unit which is a standard measure of the distance between two points." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "length unit" ; rdfs:subClassOf obo:IAO_0000003 . obo:UO_0000002 obo:IAO_0000111 "mass unit" ; obo:IAO_0000115 "A unit which is a standard measure of the amount of matter/energy of a physical object." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "mass unit" ; rdfs:subClassOf obo:IAO_0000003 . obo:UO_0000003 obo:IAO_0000111 "time unit" ; obo:IAO_0000115 "A unit which is a standard measure of the dimension in which events occur in sequence." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "time unit" ; rdfs:subClassOf obo:IAO_0000003 . obo:UO_0000005 obo:IAO_0000111 "temperature unit" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "temperature unit" ; rdfs:subClassOf obo:IAO_0000003 . obo:UO_0000006 obo:IAO_0000111 "substance unit" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "substance unit" ; rdfs:subClassOf obo:IAO_0000003 . obo:UO_0000008 obo:IAO_0000111 "meter" ; obo:IAO_0000115 "A length unit which is equal to the length of the path traveled by light in vacuum during a time interval of 1/299 792 458 of a second." ; obo:IAO_0000118 "m" ; obo:IAO_0000412 ; a obo:UO_0000001, owl:NamedIndividual ; rdfs:label "meter" . obo:UO_0000009 obo:IAO_0000111 "kilogram" ; obo:IAO_0000115 "A mass unit which is equal to the mass of the International Prototype Kilogram kept by the BIPM at Svres, France." ; obo:IAO_0000118 "kg" ; obo:IAO_0000412 ; a obo:UO_0000002, owl:NamedIndividual ; rdfs:label "kilogram" . obo:UO_0000010 obo:IAO_0000111 "second" ; obo:IAO_0000115 "A time unit which is equal to the duration of 9 192 631 770 periods of the radiation corresponding to the transition between the two hyperfine levels of the ground state of the caesium 133 atom." ; obo:IAO_0000118 "s", "sec" ; obo:IAO_0000412 ; a obo:UO_0000003, owl:NamedIndividual ; rdfs:label "second" . obo:UO_0000015 obo:IAO_0000111 "centimeter" ; obo:IAO_0000115 "A length unit which is equal to one hundredth of a meter or 10^[-2] m." ; obo:IAO_0000118 "cm" ; obo:IAO_0000412 ; a obo:UO_0000001, owl:NamedIndividual ; rdfs:label "centimeter" . obo:UO_0000016 obo:IAO_0000111 "millimeter" ; obo:IAO_0000115 "A length unit which is equal to one thousandth of a meter or 10^[-3] m." ; obo:IAO_0000118 "mm" ; obo:IAO_0000412 ; a obo:UO_0000001, owl:NamedIndividual ; rdfs:label "millimeter" . obo:UO_0000017 obo:IAO_0000111 "micrometer" ; obo:IAO_0000115 "A length unit which is equal to one millionth of a meter or 10^[-6] m." ; obo:IAO_0000118 "um" ; obo:IAO_0000412 ; a obo:UO_0000001, owl:NamedIndividual ; rdfs:label "micrometer" . obo:UO_0000018 obo:IAO_0000111 "nanometer" ; obo:IAO_0000115 "A length unit which is equal to one thousandth of one millionth of a meter or 10^[-9] m." ; obo:IAO_0000118 "nm" ; obo:IAO_0000412 ; a obo:UO_0000001, owl:NamedIndividual ; rdfs:label "nanometer" . obo:UO_0000019 obo:IAO_0000111 "angstrom" ; obo:IAO_0000115 "A length unit which is equal to 10 [-10] m." ; obo:IAO_0000412 ; a obo:UO_0000001, owl:NamedIndividual ; rdfs:label "angstrom" . obo:UO_0000021 obo:IAO_0000111 "gram" ; obo:IAO_0000115 "A mass unit which is equal to one thousandth of a kilogram or 10^[-3] kg." ; obo:IAO_0000118 "g" ; obo:IAO_0000412 ; a obo:UO_0000002, owl:NamedIndividual ; rdfs:label "gram" . obo:UO_0000022 obo:IAO_0000111 "milligram" ; obo:IAO_0000115 "A mass unit which is equal to one thousandth of a gram or 10^[-3] g." ; obo:IAO_0000118 "mg" ; obo:IAO_0000412 ; a obo:UO_0000002, owl:NamedIndividual ; rdfs:label "milligram" . obo:UO_0000023 obo:IAO_0000111 "microgram" ; obo:IAO_0000115 "A mass unit which is equal to one millionth of a gram or 10^[-6] g." ; obo:IAO_0000118 "ug" ; obo:IAO_0000412 ; a obo:UO_0000002, owl:NamedIndividual ; rdfs:label "microgram" . obo:UO_0000024 obo:IAO_0000111 "nanogram" ; obo:IAO_0000115 "A mass unit which is equal to one thousandth of one millionth of a gram or 10^[-9] g." ; obo:IAO_0000118 "ng" ; obo:IAO_0000412 ; a obo:UO_0000002, owl:NamedIndividual ; rdfs:label "nanogram" . obo:UO_0000025 obo:IAO_0000111 "picogram" ; obo:IAO_0000115 "A mass unit which is equal to 10^[-12] g." ; obo:IAO_0000118 "pg" ; obo:IAO_0000412 ; a obo:UO_0000002, owl:NamedIndividual ; rdfs:label "picogram" . obo:UO_0000027 obo:IAO_0000111 "degree Celsius" ; obo:IAO_0000115 "A temperature unit which is equal to one kelvin degree. However, they have their zeros at different points. The centigrade scale has its zero at 273.15 K." ; obo:IAO_0000118 "C", "degree C" ; obo:IAO_0000412 ; a obo:UO_0000005, owl:NamedIndividual ; rdfs:label "degree Celsius" . obo:UO_0000031 obo:IAO_0000111 "minute" ; obo:IAO_0000115 "A time unit which is equal to 60 seconds." ; obo:IAO_0000118 "min" ; obo:IAO_0000412 ; a obo:UO_0000003, owl:NamedIndividual ; rdfs:label "minute" . obo:UO_0000032 obo:IAO_0000111 "hour" ; obo:IAO_0000115 "A time unit which is equal to 3600 seconds or 60 minutes." ; obo:IAO_0000118 "h", "hr" ; obo:IAO_0000412 ; a obo:UO_0000003, owl:NamedIndividual ; rdfs:label "hour" . obo:UO_0000033 obo:IAO_0000111 "day" ; obo:IAO_0000115 "A time unit which is equal to 24 hours." ; obo:IAO_0000412 ; a obo:UO_0000003, owl:NamedIndividual ; rdfs:label "day" . obo:UO_0000034 obo:IAO_0000111 "week" ; obo:IAO_0000115 "A time unit which is equal to 7 days." ; obo:IAO_0000412 ; a obo:UO_0000003, owl:NamedIndividual ; rdfs:label "week" . obo:UO_0000035 obo:IAO_0000111 "month" ; obo:IAO_0000115 "A time unit which is approximately equal to the length of time of one of cycle of the moon's phases which in science is taken to be equal to 30 days." ; obo:IAO_0000412 ; a obo:UO_0000003, owl:NamedIndividual ; rdfs:label "month" . obo:UO_0000036 obo:IAO_0000111 "year" ; obo:IAO_0000115 "A time unit which is equal to 12 months which is science is taken to be equal to 365.25 days." ; obo:IAO_0000412 ; a obo:UO_0000003, owl:NamedIndividual ; rdfs:label "year" . obo:UO_0000039 obo:IAO_0000111 "micromole" ; obo:IAO_0000115 "A substance unit equal to a millionth of a mol or 10^[-6] mol." ; obo:IAO_0000118 "umol" ; obo:IAO_0000412 ; a obo:UO_0000006, owl:NamedIndividual ; rdfs:label "micromole" . obo:UO_0000041 obo:IAO_0000111 "nanomole" ; obo:IAO_0000115 "A substance unit equal to one thousandth of one millionth of a mole or 10^[-9] mol." ; obo:IAO_0000118 "nmol" ; obo:IAO_0000412 ; a obo:UO_0000006, owl:NamedIndividual ; rdfs:label "nanomole" . obo:UO_0000042 obo:IAO_0000111 "picomole" ; obo:IAO_0000115 "A substance unit equal to 10^[-12] mol." ; obo:IAO_0000118 "pmol" ; obo:IAO_0000412 ; a obo:UO_0000006, owl:NamedIndividual ; rdfs:label "picomole" . obo:UO_0000051 obo:IAO_0000111 "concentration unit" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "concentration unit" ; rdfs:subClassOf obo:IAO_0000003 . obo:UO_0000062 obo:IAO_0000111 "molar" ; obo:IAO_0000115 "A unit of concentration which expresses a concentration of 1 mole of solute per liter of solution (mol/L)." ; obo:IAO_0000118 "M" ; obo:IAO_0000412 ; a obo:UO_0000051, owl:NamedIndividual ; rdfs:label "molar" . obo:UO_0000063 obo:IAO_0000111 "millimolar" ; obo:IAO_0000115 "A unit of molarity which is equal to one thousandth of a molar or 10^[-3] M." ; obo:IAO_0000118 "mM" ; obo:IAO_0000412 ; a obo:UO_0000051, owl:NamedIndividual ; rdfs:label "millimolar" . obo:UO_0000064 obo:IAO_0000111 "micromolar" ; obo:IAO_0000115 "A unit of molarity which is equal to one millionth of a molar or 10^[-6] M." ; obo:IAO_0000118 "uM" ; obo:IAO_0000412 ; a obo:UO_0000051, owl:NamedIndividual ; rdfs:label "micromolar" . obo:UO_0000065 obo:IAO_0000111 "nanomolar" ; obo:IAO_0000115 "A unit of molarity which is equal to one thousandth of one millionth of a molar or 10^[-9] M." ; obo:IAO_0000118 "nM" ; obo:IAO_0000412 ; a obo:UO_0000051, owl:NamedIndividual ; rdfs:label "nanomolar" . obo:UO_0000066 obo:IAO_0000111 "picomolar" ; obo:IAO_0000115 "A unit of molarity which is equal to 10^[-12] M." ; obo:IAO_0000118 "pM" ; obo:IAO_0000412 ; a obo:UO_0000051, owl:NamedIndividual ; rdfs:label "picomolar" . obo:UO_0000095 obo:IAO_0000111 "volume unit" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "volume unit" ; rdfs:subClassOf obo:IAO_0000003 . obo:UO_0000097 obo:IAO_0000111 "cubic centimeter" ; obo:IAO_0000115 "A volume unit which is equal to one millionth of a cubic meter or 10^[-9] m^[3], or to 1 ml." ; obo:IAO_0000118 "cc" ; obo:IAO_0000412 ; a obo:UO_0000095, owl:NamedIndividual ; rdfs:label "cubic centimeter" . obo:UO_0000098 obo:IAO_0000111 "milliliter" ; obo:IAO_0000115 "A volume unit which is equal to one thousandth of a liter or 10^[-3] L, or to 1 cubic centimeter." ; obo:IAO_0000118 "ml" ; obo:IAO_0000412 ; a obo:UO_0000095, owl:NamedIndividual ; rdfs:label "milliliter" . obo:UO_0000099 obo:IAO_0000111 "liter" ; obo:IAO_0000115 "A volume unit which is equal to one thousandth of a cubic meter or 10^[-3] m^[3], or to 1 decimeter." ; obo:IAO_0000118 "L" ; obo:IAO_0000412 ; a obo:UO_0000095, owl:NamedIndividual ; rdfs:label "liter" . obo:UO_0000100 obo:IAO_0000111 "cubic decimeter" ; obo:IAO_0000115 "A volume unit which is equal to one thousand of a cubic meter or 10^[-3] m^[3], or to 1 L." ; obo:IAO_0000412 ; a obo:UO_0000095, owl:NamedIndividual ; rdfs:label "cubic decimeter" . obo:UO_0000101 obo:IAO_0000111 "microliter" ; obo:IAO_0000115 "A volume unit which is equal to one millionth of a liter or 10^[-6] L." ; obo:IAO_0000118 "ul" ; obo:IAO_0000412 ; a obo:UO_0000095, owl:NamedIndividual ; rdfs:label "microliter" . obo:UO_0000102 obo:IAO_0000111 "nanoliter" ; obo:IAO_0000115 "A volume unit which is equal to one thousandth of one millionth of a liter or 10^[-9] L." ; obo:IAO_0000118 "nl" ; obo:IAO_0000412 ; a obo:UO_0000095, owl:NamedIndividual ; rdfs:label "nanoliter" . obo:UO_0000103 obo:IAO_0000111 "picoliter" ; obo:IAO_0000115 "A volume unit which is equal to 10^[-12] L." ; obo:IAO_0000118 "pl" ; obo:IAO_0000412 ; a obo:UO_0000095, owl:NamedIndividual ; rdfs:label "picoliter" . obo:UO_0000105 obo:IAO_0000111 "frequency unit" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "frequency unit" ; rdfs:subClassOf obo:IAO_0000003 . obo:UO_0000106 obo:IAO_0000111 "hertz" ; obo:IAO_0000115 "A frequency unit which is equal to 1 complete cycle of a recurring phenomenon in 1 second." ; obo:IAO_0000412 ; a obo:UO_0000105, owl:NamedIndividual ; rdfs:label "hertz" . obo:UO_0000109 obo:IAO_0000111 "pressure unit" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "pressure unit" ; rdfs:subClassOf obo:IAO_0000003 . obo:UO_0000163 obo:IAO_0000111 "mass percentage" ; obo:IAO_0000115 "A dimensionless concentration unit which denotes the mass of a substance in a mixture as a percentage of the mass of the entire mixture." ; obo:IAO_0000118 "% w/w", "percent weight pr weight" ; obo:IAO_0000412 ; a obo:UO_0000051, owl:NamedIndividual ; rdfs:label "mass percentage" . obo:UO_0000164 obo:IAO_0000111 "mass volume percentage" ; obo:IAO_0000115 "A dimensionless concentration unit which denotes the mass of the substance in a mixture as a percentage of the volume of the entire mixture." ; obo:IAO_0000118 "% w/v", "percent vol per vol" ; obo:IAO_0000412 ; a obo:UO_0000051, owl:NamedIndividual ; rdfs:label "mass volume percentage" . obo:UO_0000165 obo:IAO_0000111 "volume percentage" ; obo:IAO_0000115 "A dimensionless concentration unit which denotes the volume of the solute in mL per 100 mL of the resulting solution." ; obo:IAO_0000118 "% v/v", "percent vol per vol" ; obo:IAO_0000412 ; a obo:UO_0000051, owl:NamedIndividual ; rdfs:label "volume percentage" . obo:UO_0000175 obo:IAO_0000111 "gram per liter" ; obo:IAO_0000115 "A mass unit density which is equal to mass of an object in grams divided by the volume in liters." ; obo:IAO_0000118 "g per L", "g/L" ; obo:IAO_0000412 ; a obo:UO_0000051, owl:NamedIndividual ; rdfs:label "gram per liter" . obo:UO_0000176 obo:IAO_0000111 "milligram per milliliter" ; obo:IAO_0000115 "A mass unit density which is equal to mass of an object in milligrams divided by the volume in milliliters." ; obo:IAO_0000118 "mg per ml", "mg/ml" ; obo:IAO_0000412 ; a obo:UO_0000051, owl:NamedIndividual ; rdfs:label "milligram per milliliter" . obo:UO_0000195 obo:IAO_0000111 "degree Fahrenheit" ; obo:IAO_0000115 "A temperature unit which is equal to 5/9ths of a kelvin. Negative 40 degrees Fahrenheit is equal to negative 40 degrees Celsius." ; obo:IAO_0000412 ; a obo:UO_0000005, owl:NamedIndividual ; rdfs:label "degree Fahrenheit" . obo:UO_0000196 obo:IAO_0000111 "pH" ; obo:IAO_0000115 "A dimensionless concentration notation which denotes the acidity of a solution in terms of activity of hydrogen ions (H+)." ; obo:IAO_0000412 ; a obo:UO_0000051, owl:NamedIndividual ; rdfs:label "pH" . obo:UO_0000207 obo:IAO_0000111 "milliliter per liter" ; obo:IAO_0000115 "A volume per unit volume unit which is equal to one millionth of a liter of solute in one liter of solution." ; obo:IAO_0000118 "ml per L", "ml/l" ; obo:IAO_0000412 ; a obo:UO_0000051, owl:NamedIndividual ; rdfs:label "milliliter per liter" . obo:UO_0000208 obo:IAO_0000111 "gram per deciliter" ; obo:IAO_0000115 "A mass density unit which is equal to mass of an object in grams divided by the volume in deciliters." ; obo:IAO_0000118 "g/dl" ; obo:IAO_0000412 ; a obo:UO_0000051, owl:NamedIndividual ; rdfs:label "gram per deciliter" . obo:UO_0000212 obo:IAO_0000111 "colony forming unit per volume" ; obo:IAO_0000115 "A concentration unit which a measure of viable bacterial numbers in a given volume." ; obo:IAO_0000412 ; a obo:UO_0000051, owl:NamedIndividual ; rdfs:label "colony forming unit per volume" . obo:UO_0000270 obo:IAO_0000111 "volumetric flow rate unit" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "volumetric flow rate unit" ; rdfs:subClassOf obo:IAO_0000003 . obo:UO_0000271 obo:IAO_0000111 "microliters per minute" ; obo:IAO_0000115 "A volumetric flow rate unit which is equal to one microliter volume through a given surface in one minute." ; obo:IAO_0000412 ; a obo:UO_0000270, owl:NamedIndividual ; rdfs:label "microliters per minute" . obo:UO_0000280 obo:IAO_0000111 "rate unit" ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "rate unit" ; rdfs:subClassOf obo:IAO_0000003 . obo:UO_0000281 obo:IAO_0000111 "count per nanomolar second" ; obo:IAO_0000115 "A rate unit which is equal to one over one nanomolar second." ; obo:IAO_0000412 ; a obo:UO_0000280, owl:NamedIndividual ; rdfs:label "count per nanomolar second" . obo:UO_0000282 obo:IAO_0000111 "count per molar second" ; obo:IAO_0000115 "A rate unit which is equal to one over one molar second." ; obo:IAO_0000412 ; a obo:UO_0000280, owl:NamedIndividual ; rdfs:label "count per molar second" . obo:UO_0000284 obo:IAO_0000111 "count per nanomolar" ; obo:IAO_0000115 "A rate unit which is equal to one over one nanomolar." ; obo:IAO_0000412 ; a obo:UO_0000280, owl:NamedIndividual ; rdfs:label "count per nanomolar" . obo:UO_0000285 obo:IAO_0000111 "count per molar" ; obo:IAO_0000115 "A rate unit which is equal to one over one molar." ; obo:IAO_0000412 ; a obo:UO_0000280, owl:NamedIndividual ; rdfs:label "count per molar" . obo:UO_0000301 obo:IAO_0000111 "microgram per liter" ; obo:IAO_0000115 "A mass unit density which is equal to mass of an object in micrograms divided by the volume in liters." ; obo:IAO_0000118 "ng/ml", "ug/L" ; obo:IAO_0000412 ; a obo:UO_0000051, owl:NamedIndividual ; rdfs:label "microgram per liter" . obo:VO_0000001 obo:IAO_0000111 "vaccine" ; obo:IAO_0000115 "A vaccine is a processed material with the function that when administered, it prevents or ameliorates a disorder in a target organism by inducing or modifying adaptive immune responses specific to the antigens in the vaccine." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "vaccine" ; rdfs:subClassOf obo:BFO_0000040 . obo:VO_0000002 obo:IAO_0000111 "vaccination" ; obo:IAO_0000115 "a process of administering substance in vivo that involves in adding a vaccine into a host (e.g., human) in vivo with the intent to invoke a protective or therapeutic adaptive immune response." ; obo:IAO_0000412 ; a owl:Class ; rdfs:label "vaccination" ; rdfs:subClassOf obo:OBI_0600007 . a owl:NamedIndividual . protege:defaultLanguage "en" ; obo:IAO_0000589 "Ontology for Biomedical Investigations"@en ; dc:contributor "Advisors for this project come from the IFOMIS group, Saarbruecken and from the Co-ODE group in Manchester"@en ; dc:creator "Alan Ruttenberg"@en, "Allyson Lister"@en, "Barry Smith"@en, "Bill Bug"@en, "Bjoern Peters"@en, "Carlo Torniai"@en, "Chris Mungall"@en, "Chris Stoeckert"@en, "Chris Taylor"@en, "Christian Bolling"@en, "Cristian Cocos"@en, "Daniel Rubin"@en, "Daniel Schober"@en, "Dawn Field"@en, "Dirk Derom"@en, "Elisabetta Manduchi"@en, "Eric Deutsch"@en, "Frank Gibson"@en, "Gilberto Fragoso"@en, "Helen C. Causton"@en, "Helen Parkinson"@en, "Holger Stenzhorn"@en, "James A. Overton"@en, "James Malone"@en, "Jay Greenbaum"@en, "Jeffrey Grethe"@en, "Jennifer Fostel"@en, "Jessica Turner"@en, "Jie Zheng"@en, "Joe White"@en, "John Westbrook"@en, "Kevin Clancy"@en, "Larisa Soldatova"@en, "Lawrence Hunter"@en, "Liju Fan"@en, "Luisa Montecchi"@en, "Matthew Brush"@en, "Matthew Pocock"@en, "Melanie Courtot"@en, "Melissa Haendel"@en, "Mervi Heiskanen"@en, "Monnie McGee"@en, "Norman Morrison"@en, "Philippe Rocca-Serra"@en, "Phillip Lord"@en, "Pierre Grenon"@en, "Richard Bruskiewich"@en, "Richard Scheuermann"@en, "Robert Stevens"@en, "Ryan R. Brinkman"@en, "Stefan Wiemann"@en, "Susanna-Assunta Sansone"@en, "Tanya Gray"@en, "Tina Hernandez-Boussard"@en, "Trish Whetzel"@en, "Yongqun He"@en ; dc:date "2009-07-31"^^xsd:date ; dc:description "An ontology for representing biomedical investigations, including study designs, the collection and preparation of the targets of investigation, assays, instrumentation and reagents used, as well as the data generated and the types of analysis performed on the data to reach conclusions, and their documentation."@en ; dc:format "OWL-DL"@en ; dc:subject "An ontology for the annotation of biomedical and functional genomics experiments."@en ; terms:license "http://creativecommons.org/licenses/by/4.0/" ; terms:title "Ontology for Biomedical Investigations" ; a owl:NamedIndividual, owl:Ontology ; rdfs:comment "Please cite the OBI consortium http://purl.obolibrary.org/obo/obi where traditional citation is called for. However it is adequate that individual terms be attributed simply by use of the identifying PURL for the term, in projects that refer to them." ; owl:versionIRI ; owl:versionInfo "2024-01-09" . dc:contributor dc:description """Examples of a Contributor include a person, an organisation, or a service. Typically, the name of a Contributor should be used to indicate the entity."""@en-us ; a owl:AnnotationProperty ; rdfs:comment """An entity responsible for making contributions to the content of the resource."""@en-us ; rdfs:isDefinedBy ; rdfs:label "Contributor", "Contributor"@en-us . dc:coverage dc:description """Coverage will typically include spatial location (a place name or geographic coordinates), temporal period (a period label, date, or date range) or jurisdiction (such as a named administrative entity). Recommended best practice is to select a value from a controlled vocabulary (for example, the Thesaurus of Geographic Names [TGN]) and that, where appropriate, named places or time periods be used in preference to numeric identifiers such as sets of coordinates or date ranges."""@en-us ; a owl:AnnotationProperty ; rdfs:comment "The extent or scope of the content of the resource."@en-us ; rdfs:isDefinedBy ; rdfs:label "Coverage", "Coverage"@en-us . dc:creator dc:description """Examples of a Creator include a person, an organisation, or a service. Typically, the name of a Creator should be used to indicate the entity."""@en-us ; a owl:AnnotationProperty ; rdfs:comment """An entity primarily responsible for making the content of the resource."""@en-us ; rdfs:isDefinedBy ; rdfs:label "Creator", "Creator"@en-us . dc:date dc:description """Typically, Date will be associated with the creation or availability of the resource. Recommended best practice for encoding the date value is defined in a profile of ISO 8601 [W3CDTF] and follows the YYYY-MM-DD format."""@en-us ; a owl:AnnotationProperty ; rdfs:comment """A date associated with an event in the life cycle of the resource."""@en-us ; rdfs:isDefinedBy ; rdfs:label "Date", "Date"@en-us . dc:description dc:description """Description may include but is not limited to: an abstract, table of contents, reference to a graphical representation of content or a free-text account of the content."""@en-us ; a owl:AnnotationProperty ; rdfs:comment "An account of the content of the resource."@en-us ; rdfs:isDefinedBy ; rdfs:label "Description", "Description"@en-us . dc:format dc:description """Typically, Format may include the media-type or dimensions of the resource. Format may be used to determine the software, hardware or other equipment needed to display or operate the resource. Examples of dimensions include size and duration. Recommended best practice is to select a value from a controlled vocabulary (for example, the list of Internet Media Types [MIME] defining computer media formats)."""@en-us ; a owl:AnnotationProperty ; rdfs:comment "The physical or digital manifestation of the resource."@en-us ; rdfs:isDefinedBy ; rdfs:label "Format", "Format"@en-us . dc:identifier dc:description """Recommended best practice is to identify the resource by means of a string or number conforming to a formal identification system. Example formal identification systems include the Uniform Resource Identifier (URI) (including the Uniform Resource Locator (URL)), the Digital Object Identifier (DOI) and the International Standard Book Number (ISBN)."""@en-us ; a owl:AnnotationProperty ; rdfs:comment "An unambiguous reference to the resource within a given context."@en-us ; rdfs:isDefinedBy ; rdfs:label "Resource Identifier", "Resource Identifier"@en-us . dc:language dc:description """Recommended best practice is to use RFC 3066 [RFC3066], which, in conjunction with ISO 639 [ISO639], defines two- and three-letter primary language tags with optional subtags. Examples include \"en\" or \"eng\" for English, \"akk\" for Akkadian, and \"en-GB\" for English used in the United Kingdom."""@en-us ; a owl:AnnotationProperty ; rdfs:comment "A language of the intellectual content of the resource."@en-us ; rdfs:isDefinedBy ; rdfs:label "Language", "Language"@en-us . dc:member a owl:AnnotationProperty . dc:publisher dc:description """Examples of a Publisher include a person, an organisation, or a service. Typically, the name of a Publisher should be used to indicate the entity."""@en-us ; a owl:AnnotationProperty ; rdfs:comment "An entity responsible for making the resource available"@en-us ; rdfs:isDefinedBy ; rdfs:label "Publisher", "Publisher"@en-us . dc:relation dc:description """ Recommended best practice is to reference the resource by means of a string or number conforming to a formal identification system. """@en-us ; a owl:AnnotationProperty ; rdfs:comment "A reference to a related resource."@en-us ; rdfs:isDefinedBy ; rdfs:label "Relation", "Relation"@en-us . dc:rights dc:description """ Typically, a Rights element will contain a rights management statement for the resource, or reference a service providing such information. Rights information often encompasses Intellectual Property Rights (IPR), Copyright, and various Property Rights. If the Rights element is absent, no assumptions can be made about the status of these and other rights with respect to the resource. """@en-us ; a owl:AnnotationProperty ; rdfs:comment "Information about rights held in and over the resource."@en-us ; rdfs:isDefinedBy ; rdfs:label "Rights Management", "Rights Management"@en-us . dc:source dc:description """The present resource may be derived from the Source resource in whole or in part. Recommended best practice is to reference the resource by means of a string or number conforming to a formal identification system."""@en-us ; a owl:AnnotationProperty ; rdfs:comment """A reference to a resource from which the present resource is derived."""@en-us ; rdfs:isDefinedBy ; rdfs:label "Source", "Source"@en-us . dc:subject dc:description """Typically, a Subject will be expressed as keywords, key phrases or classification codes that describe a topic of the resource. Recommended best practice is to select a value from a controlled vocabulary or formal classification scheme."""@en-us ; a owl:AnnotationProperty ; rdfs:comment "The topic of the content of the resource."@en-us ; rdfs:isDefinedBy ; rdfs:label "Subject and Keywords", "Subject and Keywords"@en-us . dc:title dc:description """ Typically, a Title will be a name by which the resource is formally known. """@en-us ; a owl:AnnotationProperty ; rdfs:comment "A name given to the resource."@en-us ; rdfs:isDefinedBy ; rdfs:label "Title", "Title"@en-us . dc:type dc:description """Type includes terms describing general categories, functions, genres, or aggregation levels for content. Recommended best practice is to select a value from a controlled vocabulary (for example, the DCMI Type Vocabulary [DCMITYPE]). To describe the physical or digital manifestation of the resource, use the Format element."""@en-us ; a owl:AnnotationProperty ; rdfs:comment "The nature or genre of the content of the resource."@en-us ; rdfs:isDefinedBy ; rdfs:label "Resource Type", "Resource Type"@en-us . terms:license obo:IAO_0000117 "Mark Miller" ; dc:date "2018-05-11T13:47:29Z"^^xsd:dateTime ; a owl:AnnotationProperty . terms:title a owl:AnnotationProperty . oboInOwl:ObsoleteClass a owl:Class ; rdfs:label "Obsolete Class" ; rdfs:subClassOf owl:Thing . oboInOwl:ObsoleteProperty a owl:ObjectProperty . oboInOwl:created_by a owl:AnnotationProperty . oboInOwl:creation_date a owl:AnnotationProperty . oboInOwl:shorthand a owl:AnnotationProperty ; rdfs:label "shorthand" . rdf:PlainLiteral a rdfs:Datatype . rdfs:Literal a rdfs:Datatype . rdfs:comment a owl:AnnotationProperty . rdfs:isDefinedBy a owl:AnnotationProperty . rdfs:label obo:IAO_0000111 "label" ; a owl:AnnotationProperty ; rdfs:label "label" . rdfs:seeAlso a owl:AnnotationProperty . xsd:date a rdfs:Datatype . xsd:float a rdfs:Datatype . xsd:integer a rdfs:Datatype . xsd:nonNegativeInteger a rdfs:Datatype . xsd:string a rdfs:Datatype . owl:Thing a owl:Class . foaf:homepage a owl:AnnotationProperty . foaf:mbox a owl:AnnotationProperty . foaf:page a owl:AnnotationProperty . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000006 ; owl:annotatedTarget "A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000006 ; owl:annotatedTarget "All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; rdfs:comment "per discussion with Barry Smith" ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:BFO_0000008 ; owl:annotatedTarget "Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000008 ; owl:annotatedTarget "A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000008 ; owl:annotatedTarget "All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000008 ; owl:annotatedTarget "Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000008 ; owl:annotatedTarget "(forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000008 ; owl:annotatedTarget "(forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000008 ; owl:annotatedTarget "(forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000009 ; owl:annotatedTarget "A two-dimensional spatial region is a spatial region that is of two dimensions. (axiom label in BFO2 Reference: [039-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000009 ; owl:annotatedTarget "(forall (x) (if (TwoDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [039-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000011 ; owl:annotatedTarget "A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000011 ; owl:annotatedTarget "All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000011 ; owl:annotatedTarget "Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000011 ; owl:annotatedTarget "Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000011 ; owl:annotatedTarget "Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000011 ; owl:annotatedTarget "(forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000011 ; owl:annotatedTarget "(forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000011 ; owl:annotatedTarget "(forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000011 ; owl:annotatedTarget "(forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000011 ; owl:annotatedTarget "(forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:BFO_0000015 ; owl:annotatedTarget "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000015 ; owl:annotatedTarget "(iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000016 ; owl:annotatedTarget "b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000016 ; owl:annotatedTarget "If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000016 ; owl:annotatedTarget "(forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000016 ; owl:annotatedTarget "(forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000017 ; owl:annotatedTarget "To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000017 ; owl:annotatedTarget "All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000017 ; owl:annotatedTarget "(forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000017 ; owl:annotatedTarget "(forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000018 ; owl:annotatedTarget "A zero-dimensional spatial region is a point in space. (axiom label in BFO2 Reference: [037-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000018 ; owl:annotatedTarget "(forall (x) (if (ZeroDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [037-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000019 ; owl:annotatedTarget "a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000019 ; owl:annotatedTarget "If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000019 ; owl:annotatedTarget "(forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000019 ; owl:annotatedTarget "(forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:BFO_0000020 ; owl:annotatedTarget "b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n > 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i < j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:BFO_0000020 ; owl:annotatedTarget "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; rdfs:comment "per discussion with Barry Smith" ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:BFO_0000020 ; owl:annotatedTarget "Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc."@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000020 ; owl:annotatedTarget "(iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000020 ; owl:annotatedTarget "(iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000023 ; owl:annotatedTarget "b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000023 ; owl:annotatedTarget "(forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000024 ; owl:annotatedTarget "b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000024 ; owl:annotatedTarget "(forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000026 ; owl:annotatedTarget "A one-dimensional spatial region is a line or aggregate of lines stretching from one point in space to another. (axiom label in BFO2 Reference: [038-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000026 ; owl:annotatedTarget "(forall (x) (if (OneDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [038-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:BFO_0000027 ; owl:annotatedTarget "An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:BFO_0000027 ; owl:annotatedTarget "An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000119 ; owl:annotatedSource obo:BFO_0000027 ; owl:annotatedTarget "ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158." . [] obo:IAO_0000116 "consider if we really want to be so strict here . . . ie maybe we we say that they have not been output from an 'establishing cell line' process, but in some cases a passage or two may be allowed for a primary culture. the establishing of a line requires some procedss that attains a degree of homogeneity in the culture." ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:OBI_0100061 ; owl:annotatedTarget _:genid15048 . _:genid15048 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:CHEBI_16670 [ a owl:Restriction ; owl:onProperty obo:OBI_0000312 ; owl:someValuesFrom obo:OBI_0600040 ] ) ; owl:onClass obo:OBI_0600037 ; owl:onProperty obo:OBI_0000312 ; owl:qualifiedCardinality "0"^^xsd:nonNegativeInteger . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000027 ; owl:annotatedTarget "b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000027 ; owl:annotatedTarget "(forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000028 ; owl:annotatedTarget "A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000028 ; owl:annotatedTarget "(forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000029 ; owl:annotatedTarget "b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000029 ; owl:annotatedTarget "(forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000030 ; owl:annotatedTarget "b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:BFO_0000031 ; owl:annotatedTarget "b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000031 ; owl:annotatedTarget "(iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000034 ; owl:annotatedTarget "A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000034 ; owl:annotatedTarget "(forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:BFO_0000035 ; owl:annotatedTarget "p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000035 ; owl:annotatedTarget "Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000035 ; owl:annotatedTarget "(forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000035 ; owl:annotatedTarget "(iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000038 ; owl:annotatedTarget "A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000038 ; owl:annotatedTarget "(forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000040 ; owl:annotatedTarget "A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000040 ; owl:annotatedTarget "Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000040 ; owl:annotatedTarget "every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000040 ; owl:annotatedTarget "(forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000040 ; owl:annotatedTarget "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000040 ; owl:annotatedTarget "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:BFO_0000140 ; owl:annotatedTarget "b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:BFO_0000140 ; owl:annotatedTarget "Continuant fiat boundary doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the mereological sum of two-dimensional continuant fiat boundary and a one dimensional continuant fiat boundary that doesn't overlap it. The situation is analogous to temporal and spatial regions."@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000140 ; owl:annotatedTarget "(iff (ContinuantFiatBoundary a) (and (ImmaterialEntity a) (exists (b) (and (or (ZeroDimensionalSpatialRegion b) (OneDimensionalSpatialRegion b) (TwoDimensionalSpatialRegion b)) (forall (t) (locatedInAt a b t)))) (not (exists (c t) (and (SpatialRegion c) (continuantPartOfAt c a t)))))) // axiom label in BFO2 CLIF: [029-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000142 ; owl:annotatedTarget "a one-dimensional continuant fiat boundary is a continuous fiat line whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [032-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000142 ; owl:annotatedTarget "(iff (OneDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (OneDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [032-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:BFO_0000144 ; owl:annotatedTarget "b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000144 ; owl:annotatedTarget "b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000144 ; owl:annotatedTarget "(forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000144 ; owl:annotatedTarget "(iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:BFO_0000145 ; owl:annotatedTarget "b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000145 ; owl:annotatedTarget "(iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000146 ; owl:annotatedTarget "a two-dimensional continuant fiat boundary (surface) is a self-connected fiat surface whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [033-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000146 ; owl:annotatedTarget "(iff (TwoDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (TwoDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [033-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; rdfs:comment "requested by Melanie Courtot" ; rdfs:seeAlso ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:BFO_0000147 ; owl:annotatedTarget "zero dimension continuant fiat boundaries are not spatial points. Considering the example 'the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet' : There are many frames in which that point is zooming through many points in space. Whereas, no matter what the frame, the quadripoint is always in the same relation to the boundaries of Colorado, Utah, New Mexico, and Arizona."@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000147 ; owl:annotatedTarget "a zero-dimensional continuant fiat boundary is a fiat point whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [031-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000147 ; owl:annotatedTarget "(iff (ZeroDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (ZeroDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [031-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000148 ; owl:annotatedTarget "A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000148 ; owl:annotatedTarget "(forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000182 ; owl:annotatedTarget "A history is a process that is the sum of the totality of processes taking place in the spatiotemporal region occupied by a material entity or site, including processes on the surface of the entity or within the cavities to which it serves as host. (axiom label in BFO2 Reference: [138-001])"@en . _:genid215 obo:IAO_0000116 "'derives from' is transitive, so even cell line cells created through modification of an existing cell line cell have derived_from some initial primary cultured cell that existed at some point in time." ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CLO_0000001 ; owl:annotatedTarget _:genid215 ; owl:onProperty obo:RO_0001000 ; owl:someValuesFrom obo:CL_0000001 . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000134 ; owl:annotatedTarget "To say that each spatiotemporal region s temporally_projects_onto some temporal region t is to say that t is the temporal extension of s. (axiom label in BFO2 Reference: [080-003])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000134 ; owl:annotatedTarget "To say that spatiotemporal region s spatially_projects_onto spatial region r at t is to say that r is the spatial extent of s at t. (axiom label in BFO2 Reference: [081-003])"@en . [] a owl:AllDisjointClasses ; owl:members (obo:BFO_0000004 obo:BFO_0000020 obo:BFO_0000031 ) . [] a owl:AllDisjointClasses ; owl:members (obo:BFO_0000006 obo:BFO_0000029 obo:BFO_0000140 ) . [] a owl:AllDisjointClasses ; owl:members (obo:BFO_0000008 obo:BFO_0000011 obo:BFO_0000015 obo:BFO_0000035 ) . [] a owl:AllDisjointClasses ; owl:members (obo:BFO_0000009 obo:BFO_0000018 obo:BFO_0000026 obo:BFO_0000028 ) . [] a owl:AllDisjointClasses ; owl:members (obo:BFO_0000142 obo:BFO_0000146 obo:BFO_0000147 ) . [] a owl:AllDifferent ; owl:distinctMembers (obo:IAO_0000120 obo:IAO_0000121 obo:IAO_0000122 obo:IAO_0000123 obo:IAO_0000124 obo:IAO_0000125 obo:IAO_0000423 obo:IAO_0000428 ) . [] a owl:AllDifferent ; owl:distinctMembers (obo:IAO_0000226 obo:IAO_0000227 obo:IAO_0000228 obo:IAO_0000229 ) . [] obo:IAO_0000116 "This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation." ; a owl:Axiom ; owl:annotatedProperty rdfs:domain ; owl:annotatedSource obo:RO_0001025 ; owl:annotatedTarget obo:BFO_0000004 . [] obo:IAO_0000116 "This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation." ; a owl:Axiom ; owl:annotatedProperty rdfs:range ; owl:annotatedSource obo:RO_0001025 ; owl:annotatedTarget obo:BFO_0000004 . [] obo:IAO_0010000 ; a owl:Axiom ; rdfs:comment "per discussion with Barry Smith" ; rdfs:seeAlso ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:BFO_0000001 ; owl:annotatedTarget "Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000001 ; owl:annotatedTarget "An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:BFO_0000002 ; owl:annotatedTarget "Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000002 ; owl:annotatedTarget "A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000002 ; owl:annotatedTarget "if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000002 ; owl:annotatedTarget "if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000002 ; owl:annotatedTarget "if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000002 ; owl:annotatedTarget "(forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000002 ; owl:annotatedTarget "(forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000002 ; owl:annotatedTarget "(forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000002 ; owl:annotatedTarget "(forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] " . [] obo:IAO_0010000 ; a owl:Axiom ; rdfs:comment "per discussion with Barry Smith" ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:BFO_0000003 ; owl:annotatedTarget "Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process."@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:BFO_0000003 ; owl:annotatedTarget "Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame." . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000600 ; owl:annotatedSource obo:BFO_0000003 ; owl:annotatedTarget "An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000003 ; owl:annotatedTarget "Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000003 ; owl:annotatedTarget "b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000003 ; owl:annotatedTarget "(forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000003 ; owl:annotatedTarget "(forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:BFO_0000004 ; owl:annotatedTarget "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000004 ; owl:annotatedTarget "For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000601 ; owl:annotatedSource obo:BFO_0000004 ; owl:annotatedTarget "For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])"@en . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000004 ; owl:annotatedTarget "(forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000004 ; owl:annotatedTarget "(forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000004 ; owl:annotatedTarget "(iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000006 ; owl:annotatedTarget "(forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000602 ; owl:annotatedSource obo:BFO_0000006 ; owl:annotatedTarget "(forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001] " . [] obo:IAO_0010000 ; a owl:Axiom ; rdfs:comment "per discussion with Barry Smith" ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:BFO_0000006 ; owl:annotatedTarget "Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional."@en .