@prefix rdf: . @prefix : . @prefix dc: . @prefix obo: . @prefix owl: . @prefix xml: . @prefix xsd: . @prefix cito: . @prefix foaf: . @prefix rdfs: . @prefix skos: . @prefix swrl: . @prefix swrla: . @prefix swrlb: . @prefix terms: . @prefix subsets: . @prefix oboInOwl: . obo:BFO_0000002 rdfs:subClassOf [ a owl:Restriction ; owl:allValuesFrom obo:BFO_0000002 ; owl:onProperty obo:RO_0002214 ], [ a owl:Restriction ; owl:allValuesFrom obo:BFO_0000002 ; owl:onProperty obo:RO_HOM0000000 ] . obo:BFO_0000003 rdfs:subClassOf [ a owl:Restriction ; owl:allValuesFrom obo:BFO_0000003 ; owl:onProperty obo:RO_HOM0000000 ] . obo:BFO_0000015 rdfs:subClassOf [ a owl:Restriction ; owl:allValuesFrom obo:BFO_0000015 ; owl:onProperty obo:RO_0002214 ] . obo:BFO_0000050 obo:RO_0040042 obo:BFO_0000002, obo:BFO_0000003, obo:BFO_0000004, obo:BFO_0000017, obo:BFO_0000019, obo:BFO_0000020, obo:BFO_0000031 ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_gp2term, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:seeAlso , ; rdfs:subPropertyOf obo:RO_0002131 . obo:BFO_0000051 oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:subPropertyOf obo:RO_0002131 . obo:BFO_0000060 owl:deprecated true . obo:BFO_0000062 oboInOwl:inSubset subsets:ro-eco ; owl:propertyChainAxiom (obo:BFO_0000050 obo:BFO_0000062 ) . obo:BFO_0000063 oboInOwl:inSubset subsets:ro-eco ; rdfs:subPropertyOf obo:RO_0002222 ; owl:propertyChainAxiom (obo:BFO_0000050 obo:BFO_0000063 ), (obo:RO_0002092 obo:BFO_0000063 ) . obo:BFO_0000066 oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam . obo:CARO_0000006 rdfs:subClassOf [ a owl:Restriction ; owl:allValuesFrom obo:CARO_0000003 ; owl:onProperty obo:RO_0002179 ] . obo:CL_0000101 a owl:Class . obo:GO_0004842 rdfs:subClassOf [ a owl:Restriction ; owl:hasSelf true ; owl:onProperty obo:RO_0002482 ] . obo:GO_0004872 a owl:Class . obo:GO_0016301 rdfs:subClassOf [ a owl:Restriction ; owl:hasSelf true ; owl:onProperty obo:RO_0002481 ] . obo:GO_0044403 rdfs:subClassOf [ a owl:Restriction ; owl:hasSelf true ; owl:onProperty obo:RO_0002465 ] . obo:GO_0072519 rdfs:subClassOf [ a owl:Restriction ; owl:hasSelf true ; owl:onProperty obo:RO_0002468 ] . obo:GO_0085030 rdfs:subClassOf [ a owl:Restriction ; owl:hasSelf true ; owl:onProperty obo:RO_0002467 ] . obo:GO_0085031 rdfs:subClassOf [ a owl:Restriction ; owl:hasSelf true ; owl:onProperty obo:RO_0002466 ] . obo:IAO_0000232 a owl:AnnotationProperty . obo:IAO_0000426 obo:IAO_0000115 "An assertion that holds between an OWL Object Property and a string or literal, where the value of the string or literal is a Common Logic sentence of collection of sentences that define the Object Property." ; rdfs:subPropertyOf obo:RO_0002422 . obo:IAO_0000589 a owl:AnnotationProperty . obo:RO_0000052 rdfs:subPropertyOf obo:RO_0002314 . obo:RO_0000057 owl:propertyChainAxiom (obo:BFO_0000051 obo:RO_0000057 ), (obo:BFO_0000051 obo:BFO_0000055 obo:RO_0000052 ) . obo:RO_0000092 obo:IAO_0000115 "inverse of has disposition" ; oboInOwl:inSubset obo:RO_0002259 . obo:RO_0000300 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "OBSOLETE A relation that holds between two neurons connected directly via a synapse, or indirectly via a series of synaptically connected neurons."@en ; obo:IAO_0000117 "David Osumi-Sutherland"@en ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:comment "Obsoleted as no longer a useful relationship (all neurons in an organism are in a neural circuit with each other)." ; rdfs:label "obsolete in neural circuit with"@en ; owl:deprecated true . obo:RO_0000301 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "OBSOLETE A relation that holds between a neuron that is synapsed_to another neuron or a neuron that is connected indirectly to another by a chain of neurons, each synapsed_to the next, in which the direction is from the last to the first."@en ; obo:IAO_0000117 "David Osumi-Sutherland"@en ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:comment "Obsoleted as no longer a useful relationship (all neurons in an organism are in a neural circuit with each other)." ; rdfs:label "obsolete upstream in neural circuit with"@en ; owl:deprecated true . obo:RO_0000302 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "OBSOLETE A relation that holds between a neuron that is synapsed_by another neuron or a neuron that is connected indirectly to another by a chain of neurons, each synapsed_by the next, in which the direction is from the last to the first."@en ; obo:IAO_0000117 "David Osumi-Sutherland"@en ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:comment "Obsoleted as no longer a useful relationship (all neurons in an organism are in a neural circuit with each other)." ; rdfs:label "obsolete downstream in neural circuit with"@en ; owl:deprecated true . obo:RO_0001000 obo:IAO_0000232 "This relation is taken from the RO2005 version of RO. It may be obsoleted and replaced by relations with different definitions. See also the 'develops from' family of relations." ; oboInOwl:inSubset subsets:ro-eco . obo:RO_0001001 oboInOwl:inSubset subsets:ro-eco . obo:RO_0001018 obo:IAO_0000111 "contained in"@en ; obo:IAO_0000116 "Containment is location not involving parthood, and arises only where some immaterial continuant is involved.", "Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation. If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows: c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t. The containment relation on the instance level can then be defined (see definition):"@en, """Intended meaning: domain: material entity range: spatial region or site (immaterial continuant) """@en ; obo:IAO_0000118 "contained_in"@en ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "contained in"@en ; rdfs:range obo:BFO_0000004 ; owl:inverseOf obo:RO_0001019 ; owl:propertyChainAxiom (obo:RO_0001025 obo:BFO_0000050 ) . obo:RO_0001019 obo:IAO_0000111 "contains"@en ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "contains"@en . obo:RO_0001020 obo:IAO_0000112 "penicillin (CHEBI:17334) is allergic trigger for penicillin allergy (DOID:0060520)" ; obo:IAO_0000115 "A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "is allergic trigger for"@en ; rdfs:subPropertyOf obo:RO_0003302 ; owl:inverseOf obo:RO_0001022 . obo:RO_0001021 obo:IAO_0000115 "A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "is autoimmune trigger for"@en ; rdfs:subPropertyOf obo:RO_0003302 ; owl:inverseOf obo:RO_0001023 . obo:RO_0001022 obo:IAO_0000112 "penicillin allergy (DOID:0060520) has allergic trigger penicillin (CHEBI:17334)" ; obo:IAO_0000115 "A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." ; a owl:ObjectProperty ; rdfs:label "has allergic trigger"@en ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0003302 . obo:RO_0001023 obo:IAO_0000115 "A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." ; a owl:ObjectProperty ; rdfs:label "has autoimmune trigger"@en ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0003302 . obo:RO_0001025 oboInOwl:inSubset obo:valid_for_go_gp2term ; owl:propertyChainAxiom (obo:RO_0001025 obo:BFO_0000050 ) . obo:RO_0001900 obo:IAO_0000115 "An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context." ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002422 . obo:RO_0002000 rdfs:subPropertyOf obo:RO_0002323 . obo:RO_0002001 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000116 "May be obsoleted, see https://github.com/oborel/obo-relations/issues/260" ; obo:IAO_0000117 "David Osumi-Sutherland" ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "aligned with"@en . obo:RO_0002002 obo:IAO_0000117 "David Osumi-Sutherland" ; rdfs:subPropertyOf obo:RO_0002323 . obo:RO_0002003 obo:IAO_0000115 "A relation that holds between two neurons that are electrically coupled via gap junctions." ; obo:IAO_0000117 "David Osumi-Sutherland" ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:label "electrically_synapsed_to"^^xsd:string ; rdfs:subPropertyOf obo:RO_0002170 . obo:RO_0002004 obo:IAO_0000115 "The relationship that holds between a trachea or tracheole and an antomical structure that is contained in (and so provides an oxygen supply to)."^^xsd:string ; obo:IAO_0000117 "David Osumi-Sutherland" ; a owl:ObjectProperty ; rdfs:domain obo:CARO_0000003 ; rdfs:label "tracheates"@en ; rdfs:range obo:CARO_0000003 ; rdfs:subPropertyOf obo:RO_0001018 . obo:RO_0002005 obo:IAO_0000117 "David Osumi-Sutherland" ; cito:citesAsAuthority "http://www.ncbi.nlm.nih.gov/pubmed/22402613"^^xsd:anyURI ; a owl:ObjectProperty ; rdfs:domain obo:CARO_0000003 ; rdfs:label "innervated_by"@en ; rdfs:range obo:CARO_0001001 ; owl:inverseOf obo:RO_0002134 . obo:RO_0002006 obo:IAO_0000117 "David Osumi-Sutherland" ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:label "has synaptic terminal of"@en ; rdfs:subPropertyOf obo:RO_0002131 ; owl:inverseOf obo:RO_0002130 . obo:RO_0002007 obo:IAO_0000115 """X outer_layer_of Y iff: . X :continuant that bearer_of some PATO:laminar . X part_of Y . exists Z :surface . X has_boundary Z . Z boundary_of Y has_boundary: http://purl.obolibrary.org/obo/RO_0002002 boundary_of: http://purl.obolibrary.org/obo/RO_0002000""" ; obo:IAO_0000117 "David Osumi-Sutherland" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:comment "A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane." ; rdfs:domain [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002124 ] ) ] ; rdfs:label "bounding layer of"@en ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:BFO_0000050 . obo:RO_0002008 obo:IAO_0000115 "A relation that holds between two linear structures that are approximately parallel to each other for their entire length and where either the two structures are adjacent to each other or one is part of the other."^^xsd:string ; obo:IAO_0000116 "Note from NCEAS meeting: consider changing primary label" ; obo:IAO_0000117 "David Osumi-Sutherland" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:comment "Example: if we define region of chromosome as any subdivision of a chromosome along its long axis, then we can define a region of chromosome that contains only gene x as 'chromosome region' that coincident_with some 'gene x', where the term gene X corresponds to a genomic sequence." ; rdfs:domain [ a owl:Class ; owl:intersectionOf (obo:BFO_0000002 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001199 ] ) ] ; rdfs:label "coincident with" ; rdfs:range [ a owl:Class ; owl:intersectionOf (obo:BFO_0000002 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001199 ] ) ] ; rdfs:subPropertyOf obo:RO_0002323 . obo:RO_0002009 obo:IAO_0000115 "A relation that applies between a cell(c) and a gene(g) , where the process of 'transcription, DNA templated (GO_0006351)' is occuring in in cell c and that process has input gene g." ; obo:IAO_0000117 "David Osumi-Sutherland" ; terms:description """x 'cell expresses' y iff: cell(x) AND gene(y) AND exists some 'transcription, DNA templated (GO_0006351)'(t) AND t occurs_in x AND t has_input y""" ; a owl:ObjectProperty ; rdfs:domain obo:CL_0000000 ; rdfs:label "cell expresses" ; rdfs:subPropertyOf obo:RO_0002292 . obo:RO_0002010 obo:IAO_0000115 "x 'regulates in other organism' y if and only if: (x is the realization of a function to exert an effect on the frequency, rate or extent of y) AND (the agents of x are produced by organism o1 and the agents of y are produced by organism o2)." ; obo:IAO_0000117 "David Osumi-Sutherland" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "regulates in other organism" ; rdfs:range obo:BFO_0000015 ; rdfs:subPropertyOf obo:RO_0002418 . obo:RO_0002011 obo:IAO_0000115 "A relationship that holds between a process that regulates a transport process and the entity transported by that process." ; obo:IAO_0000117 "David Osumi-Sutherland" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "regulates transport of" ; owl:propertyChainAxiom (obo:RO_0002211 obo:RO_0002313 ) . obo:RO_0002012 obo:IAO_0000115 "A part of relation that applies only between occurents." ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000003 ; rdfs:label "occurent part of" ; rdfs:range obo:BFO_0000003 ; rdfs:subPropertyOf obo:BFO_0000050, obo:RO_0002418 . obo:RO_0002013 obo:IAO_0000115 "A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B." ; oboInOwl:created_by "dos"^^xsd:string ; oboInOwl:creation_date "2017-05-24T09:30:46Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "has regulatory component activity" ; rdfs:subPropertyOf obo:RO_0002017, obo:RO_0002334 . obo:RO_0002014 obo:IAO_0000115 "A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B." ; oboInOwl:created_by "dos"^^xsd:string ; oboInOwl:creation_date "2017-05-24T09:31:01Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:comment "By convention GO molecular functions are classified by their effector function. Internal regulatory functions are treated as components. For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'." ; rdfs:label "has negative regulatory component activity" ; rdfs:subPropertyOf obo:RO_0002013, obo:RO_0002335 . obo:RO_0002015 obo:IAO_0000115 "A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B." ; oboInOwl:created_by "dos"^^xsd:string ; oboInOwl:creation_date "2017-05-24T09:31:17Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:comment "By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'." ; rdfs:label "has positive regulatory component activity" ; rdfs:subPropertyOf obo:RO_0002013, obo:RO_0002336 . obo:RO_0002016 oboInOwl:created_by "dos"^^xsd:string ; oboInOwl:creation_date "2017-05-24T09:36:08Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:comment "A has necessary component activity B if A and B are GO molecular functions (GO_0003674), A has_component B and B is necessary for A. For example, ATPase coupled transporter activity has necessary component ATPase activity; transcript factor activity has necessary component DNA binding activity." ; rdfs:label "has necessary component activity" ; rdfs:subPropertyOf obo:RO_0002017, obo:RO_0002336 . obo:RO_0002017 oboInOwl:created_by "dos"^^xsd:string ; oboInOwl:creation_date "2017-05-24T09:44:33Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:comment "A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B." ; rdfs:label "has component activity" ; rdfs:subPropertyOf obo:RO_0002018 . obo:RO_0002018 obo:IAO_0000115 "w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." ; oboInOwl:created_by "dos"^^xsd:string ; oboInOwl:creation_date "2017-05-24T09:49:21Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "has component process" ; rdfs:range obo:BFO_0000015 ; rdfs:subPropertyOf obo:RO_0002180 . obo:RO_0002019 obo:IAO_0000115 "A relationship that holds between between a receptor and an chemical entity, typically a small molecule or peptide, that carries information between cells or compartments of a cell and which binds the receptor and regulates its effector function." ; oboInOwl:created_by "dos"^^xsd:string ; oboInOwl:creation_date "2017-07-19T17:30:36Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "has ligand" ; rdfs:subPropertyOf obo:RO_0002233 . obo:RO_0002020 obo:IAO_0000115 "Holds between p and c when p is a transport process or transporter activity and the outcome of this p is to move c from one location to another." ; oboInOwl:created_by "dos"^^xsd:string ; oboInOwl:creation_date "2017-07-20T17:11:08Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "transports" ; rdfs:subPropertyOf obo:RO_0002313 . obo:RO_0002021 obo:IAO_0000115 "A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization." ; oboInOwl:created_by "dos"^^xsd:string ; oboInOwl:creation_date "2017-07-20T17:19:37Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "occurs across" ; rdfs:subPropertyOf obo:RO_0002479 . obo:RO_0002022 oboInOwl:created_by "dos"^^xsd:string ; oboInOwl:creation_date "2017-09-17T13:52:24Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:comment "Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2." ; rdfs:label "directly regulated by" ; rdfs:subPropertyOf obo:RO_0002334 ; owl:inverseOf obo:RO_0002578 . obo:RO_0002023 obo:IAO_0000115 "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." ; oboInOwl:created_by "dos"^^xsd:string ; oboInOwl:creation_date "2017-09-17T13:52:38Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "directly negatively regulated by" ; rdfs:subPropertyOf obo:RO_0002022 ; owl:inverseOf obo:RO_0002630 . obo:RO_0002024 obo:IAO_0000115 "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." ; oboInOwl:created_by "dos"^^xsd:string ; oboInOwl:creation_date "2017-09-17T13:52:47Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "directly positively regulated by" ; rdfs:subPropertyOf obo:RO_0002022 ; owl:inverseOf obo:RO_0002629 . obo:RO_0002025 obo:IAO_0000115 "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity." ; oboInOwl:created_by "dos"^^xsd:string ; oboInOwl:creation_date "2017-09-22T14:14:36Z"^^xsd:dateTime ; a owl:FunctionalProperty, owl:ObjectProperty ; rdfs:comment "This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations." ; rdfs:label "has effector activity" ; rdfs:subPropertyOf obo:RO_0002017 . obo:RO_0002026 obo:IAO_0000115 """A relationship that holds between two images, A and B, where: A depicts X; B depicts Y; X and Y are both of type T' C is a 2 layer image consiting of layers A and B; A and B are aligned in C according to a shared co-ordinate framework so that common features of X and Y are co-incident with each other. Note: A and B may be 2D or 3D. Examples include: the relationship between two channels collected simultaneously from a confocal microscope; the relationship between an image dpeicting X and a painted annotation layer that delineates regions of X; the relationship between the tracing of a neuron on an EM stack and the co-ordinate space of the stack; the relationship between two separately collected images that have been brought into register via some image registration software.""" ; oboInOwl:created_by "dos"^^xsd:string ; oboInOwl:creation_date "2017-12-07T12:58:06Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:domain foaf:image ; rdfs:label "in register with"@en ; rdfs:range foaf:image ; rdfs:subPropertyOf obo:RO_0002323 . obo:RO_0002029 obo:IAO_0000115 "Then percentage of organisms in a population that die during some specified age range (age-specific mortality rate), minus the percentage that die in during the same age range in a wild-type population." ; oboInOwl:created_by "dos"^^xsd:string ; oboInOwl:creation_date "2018-05-22T16:43:28Z"^^xsd:dateTime ; a owl:DatatypeProperty ; rdfs:comment "This could be used to record the increased infant morality rate in some population compared to wild-type. For examples of usage see http://purl.obolibrary.org/obo/FBcv_0000351 and subclasses." ; rdfs:label "has increased age-specific mortality rate"@en ; rdfs:range [ a rdfs:Datatype ; owl:onDatatype xsd:short ; owl:withRestrictions ([ xsd:minInclusive "0"^^xsd:short ] [ xsd:maxInclusive "100"^^xsd:short ] ) ] . obo:RO_0002081 oboInOwl:inSubset subsets:ro-eco . obo:RO_0002082 obo:IAO_0000117 "David Osumi-Sutherland" ; oboInOwl:inSubset subsets:ro-eco . obo:RO_0002083 oboInOwl:inSubset subsets:ro-eco . obo:RO_0002084 oboInOwl:inSubset subsets:ro-eco . obo:RO_0002085 obo:IAO_0000117 "David Osumi-Sutherland" ; obo:IAO_0000118 "di" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:comment "Previously had ID http://purl.obolibrary.org/obo/RO_0002124 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point. No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line. Official ID now chosen from DOS ID range." ; rdfs:label "encompasses"@en ; rdfs:subPropertyOf obo:RO_0002088 ; owl:inverseOf obo:RO_0002092 . obo:RO_0002086 oboInOwl:inSubset subsets:ro-eco . obo:RO_0002087 owl:propertyChainAxiom (obo:RO_0002224 obo:RO_0002230 ) . obo:RO_0002088 oboInOwl:inSubset subsets:ro-eco . obo:RO_0002089 oboInOwl:inSubset subsets:ro-eco . obo:RO_0002090 obo:IAO_0000117 "David Osumi-Sutherland" ; obo:RO_0002575 obo:BFO_0000063 ; oboInOwl:inSubset subsets:ro-eco ; owl:propertyChainAxiom (obo:RO_0002230 obo:RO_0002224 ) . obo:RO_0002091 oboInOwl:inSubset subsets:ro-eco . obo:RO_0002092 oboInOwl:inSubset subsets:ro-eco, obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; rdfs:subPropertyOf obo:RO_0002091 . obo:RO_0002093 oboInOwl:inSubset subsets:ro-eco . obo:RO_0002100 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Relation between a neuron and an anatomical structure that its soma is part of."@en ; obo:IAO_0000117 "David Osumi-Sutherland" ; obo:IAO_0000424 """ some ( and some ?Y)""" ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:domain obo:CL_0000540 ; rdfs:label "has soma location"@en ; rdfs:range obo:CARO_0000003 ; rdfs:subPropertyOf obo:RO_0002131 ; owl:propertyChainAxiom (obo:RO_0002100 obo:BFO_0000050 ) . obo:RO_0002101 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 """relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through. """@en ; obo:IAO_0000117 "David Osumi-Sutherland" ; obo:IAO_0000118 "fasciculates with" ; obo:IAO_0000426 """(forall (?x ?y) (iff (fasciculates_with ?x ?y) (exists (?nps ?npbs) (and (\"neuron ; CL_0000540\" ?x) (\"neuron projection bundle ; CARO_0001001\" ?y) (\"neuron projection segment ; CARO_0001502\" ?nps) (\"neuron projection bundle segment ; CARO_0001500' \" ?npbs) (part_of ?npbs ?y) (part_of ?nps ?x) (part_of ?nps ?npbs) (forall (?npbss) (if (and (\"neuron projection bundle subsegment ; CARO_0001501\" ?npbss) (part_of ?npbss ?npbs) ) (overlaps ?nps ?npbss) ))))))"""^^xsd:string ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:domain obo:CL_0000540 ; rdfs:label "fasciculates with"@en ; rdfs:range obo:CARO_0001001 ; rdfs:subPropertyOf obo:RO_0002131 ; owl:inverseOf obo:RO_0002132 . obo:RO_0002102 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Relation between a neuron and some structure its axon forms (chemical) synapses in."@en ; obo:IAO_0000117 "Chris Mungall"@en, "David Osumi-Sutherland", "David Osumi-Sutherland"@en ; obo:IAO_0000424 """ some ( and some ( and some ( and some ?Y)))""" ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:domain obo:CL_0000540 ; rdfs:label "axon synapses in"@en ; rdfs:subPropertyOf obo:RO_0002113 ; owl:propertyChainAxiom (obo:RO_0002102 obo:BFO_0000050 ) . obo:RO_0002103 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. "@en ; obo:IAO_0000117 "Chris Mungall"@en, "David Osumi-Sutherland"@en ; obo:IAO_0000424 " some ( that part_of some ( that has_part some ( that some Y?)))" ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:label "synapsed by"@en ; rdfs:range [ a owl:Class ; owl:unionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000540 ] ) ] ; rdfs:subPropertyOf obo:RO_0002485 ; owl:inverseOf obo:RO_0002120 . obo:RO_0002104 obo:IAO_0000112 "Every B cell[CL_0000236] has plasma membrane part some immunoglobulin complex[GO_0019814]"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part." ; obo:IAO_0000117 "Alexander Diehl", "Chris Mungall"@en, "Lindsay Cowell" ; obo:IAO_0000119 ; obo:IAO_0000424 " some ( and some ?Y)" ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:domain obo:CARO_0000006 ; rdfs:label "has plasma membrane part"@en ; rdfs:range obo:CARO_0000006 ; rdfs:subPropertyOf obo:BFO_0000051 . obo:RO_0002105 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A relation between a motor neuron and a muscle that it synapses to via a type Ib bouton." ; obo:IAO_0000117 "David Osumi-Sutherland", "Marta Costa" ; obo:IAO_0000424 "BFO_0000051 some (GO_0061176 that BFO_0000051 some (that BFO_0000051 some (GO_0045202 that BFO_0000051 some ( that BFO_0000050 some ?Y))))" ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:comment "Expands to: has_part some ('type Ib terminal button' that has_part some ('pre-synaptic membrane' that part_of some ('synapse' that has_part some ('post-synaptic membrane' that part_of some ?Y))))" ; rdfs:label "synapsed_via_type_Ib_bouton_to"@en ; rdfs:subPropertyOf obo:RO_0002120 ; owl:inverseOf obo:RO_0002109 . obo:RO_0002106 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A relation between a motor neuron and a muscle that it synapses to via a type Is bouton." ; obo:IAO_0000117 "David Osumi-Sutherland", "Marta Costa" ; obo:IAO_0000424 "BFO_0000051 some (GO_0061177 that BFO_0000051 some (that BFO_0000051 some (GO_0045202 that BFO_0000051 some ( that BFO_0000050 some ?Y))))" ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:comment "Expands to: has_part some ('type Is terminal button' that has_part some ('pre-synaptic membrane' that part_of some ('synapse' that has_part some ('post-synaptic membrane' that part_of some ?Y))))" ; rdfs:label "synapsed_via_type_Is_bouton_to"@en ; rdfs:subPropertyOf obo:RO_0002120 ; owl:inverseOf obo:RO_0002112 . obo:RO_0002107 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A relation between a motor neuron and a muscle that it synapses to via a type II bouton." ; obo:IAO_0000117 "David Osumi-Sutherland", "Marta Costa" ; obo:IAO_0000424 "BFO_0000051 some (GO_0061175 that BFO_0000051 some (that BFO_0000051 some (GO_0045202 that BFO_0000051 some ( that BFO_0000050 some ?Y))))" ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:comment "Expands to: has_part some ('type II terminal button' that has_part some ('pre-synaptic membrane' that part_of some ('synapse' that has_part some ('post-synaptic membrane' that part_of some ?Y))))" ; rdfs:label "synapsed_via_type_II_bouton_to"@en ; rdfs:subPropertyOf obo:RO_0002120 ; owl:inverseOf obo:RO_0002108 . obo:RO_0002108 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Relation between a muscle and a motor neuron that synapses to it via a type II bouton." ; obo:IAO_0000117 "David Osumi-Sutherland", "Marta Costa" ; obo:IAO_0000424 """BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0061174 that BFO_0000051 some GO_0045211 that BFO_0000050 some ?Y))) """ ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:comment "Expands to: has_part some ('presynaptic membrane' that part_of some ('synapse' that has_part some ('type II terminal button' that has_part some 'postsynaptic membrane' that part_of some ?Y)))))" ; rdfs:label "synapsed_by_via_type_II_bouton"@en ; rdfs:subPropertyOf obo:RO_0002103 . obo:RO_0002109 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Relation between a muscle and a motor neuron that synapses to it via a type Ib bouton." ; obo:IAO_0000117 "David Osumi-Sutherland", "Marta Costa" ; obo:IAO_0000424 "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0061176 that BFO_0000051 some GO_0045211 that BFO_0000050 some ?Y)))" ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:comment "Expands to: has_part some ('presynaptic membrane' that part_of some ('synapse' that has_part some ('type Ib terminal button' that has_part some 'postsynaptic membrane' that part_of some ?Y)))))" ; rdfs:label "synapsed_by_via_type_Ib_bouton"@en ; rdfs:subPropertyOf obo:RO_0002103 . obo:RO_0002110 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. "@en ; obo:IAO_0000117 "Chris Mungall"@en, "David Osumi-Sutherland"@en ; obo:IAO_0000118 "synapsed in"@en ; obo:IAO_0000424 """http://purl.obolibrary.org/obo/BFO_0000051 some ( http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some ( http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))""" ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:domain obo:CL_0000540 ; rdfs:label "has postsynaptic terminal in"@en ; rdfs:subPropertyOf obo:RO_0002130 ; owl:inverseOf obo:RO_0002113 ; owl:propertyChainAxiom (obo:RO_0002110 obo:BFO_0000050 ) . obo:RO_0002111 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000118 "has neurotransmitter" ; a owl:ObjectProperty ; rdfs:domain obo:CARO_0000003 ; rdfs:label "releases neurotransmitter"@en ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf owl:topObjectProperty . obo:RO_0002112 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Relation between a muscle and a motor neuron that synapses to it via a type Is bouton." ; obo:IAO_0000117 "David Osumi-Sutherland", "Marta Costa" ; obo:IAO_0000424 "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0061177 that BFO_0000051 some GO_0045211 that BFO_0000050 some ?Y)))" ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:comment "Expands to: has_part some ('presynaptic membrane' that part_of some ('synapse' that has_part some ('type Is terminal button' that has_part some 'postsynaptic membrane' that part_of some ?Y)))))" ; rdfs:label "synapsed_by_via_type_Is_bouton"@en ; rdfs:subPropertyOf obo:RO_0002103 . obo:RO_0002113 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input."@en ; obo:IAO_0000118 "synapses in"@en ; obo:IAO_0000424 " some ( that some ( that some Y?)"@en ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:domain obo:CL_0000540 ; rdfs:label "has presynaptic terminal in"@en ; rdfs:subPropertyOf obo:RO_0002130 ; owl:propertyChainAxiom (obo:RO_0002113 obo:BFO_0000050 ) . obo:RO_0002114 obo:IAO_0000115 "A relation between a motor neuron and a muscle that it synapses to via a type III bouton." ; obo:IAO_0000424 "BFO_0000051 some (GO_0061177 that BFO_0000051 some (that BFO_0000051 some (GO_0097467 that BFO_0000051 some ( that BFO_0000050 some ?Y))))" ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:comment "Expands to: has_part some ('type III terminal button' that has_part some ('pre-synaptic membrane' that part_of some ('synapse' that has_part some ('post-synaptic membrane' that part_of some ?Y))))" ; rdfs:label "synapsed_via_type_III_bouton_to"@en ; rdfs:subPropertyOf obo:RO_0002120 ; owl:inverseOf obo:RO_0002115 . obo:RO_0002115 obo:IAO_0000115 """Relation between a muscle and a motor neuron that synapses to it via a type III bouton. """ ; obo:IAO_0000424 "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0097467 that BFO_0000051 some GO_0045211 that BFO_0000050 some ?Y)))" ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:comment "Expands to: has_part some ('presynaptic membrane' that part_of some ('synapse' that has_part some ('type III terminal button' that has_part some 'postsynaptic membrane' that part_of some ?Y)))))" ; rdfs:label "synapsed_by_via_type_III_bouton"@en ; rdfs:subPropertyOf obo:RO_0002103 . obo:RO_0002120 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 """ Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to. """@en ; obo:IAO_0000117 "Chris Mungall"@en, "David Osumi-Sutherland"@en ; obo:IAO_0000424 " some ( that part_of some ( that some ( that some Y?)))" ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:comment """N1 synapsed_to some N2 Expands to: N1 SubclassOf ( has_part some ( ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( ‘synapse ; GO:0045202’ that has_part some ( ‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))""" ; rdfs:domain [ a owl:Class ; owl:unionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000540 ] ) ] ; rdfs:label "synapsed to"@en ; rdfs:subPropertyOf obo:RO_0002486 . obo:RO_0002121 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 """Relation between a neuron and some structure (e.g.- a brain region) in which its dendrite receives synaptic input. """@en ; obo:IAO_0000117 "Chris Mungall"@en, "David Osumi-Sutherland"@en ; obo:IAO_0000424 """ some ( and some ( http://purl.obolibrary.org/obo/GO_0042734 and some ( and some ?Y)))""" ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:domain obo:CL_0000540 ; rdfs:label "dendrite synapsed in"@en ; rdfs:subPropertyOf obo:RO_0002110 ; owl:propertyChainAxiom (obo:RO_0002121 obo:BFO_0000050 ) . obo:RO_0002130 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." ; obo:IAO_0000117 "David Osumi-Sutherland"@en ; obo:IAO_0000118 "has synapse in" ; obo:IAO_0000424 " some ( that some Y?)" ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:domain obo:CL_0000540 ; rdfs:label "has synaptic terminal in"@en ; rdfs:subPropertyOf obo:RO_0002131 ; owl:propertyChainAxiom (obo:RO_0002130 obo:BFO_0000050 ) . obo:RO_0002131 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x overlaps y if and only if there exists some z such that x has part z and z part of y" ; obo:IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)" ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:inSubset subsets:ro-eco, obo:valid_for_go_annotation_extension, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "overlaps"@en ; rdfs:subPropertyOf obo:RO_0002323 ; owl:propertyChainAxiom (obo:BFO_0000050 obo:BFO_0000050 ), (obo:BFO_0000051 obo:BFO_0000050 ), (obo:BFO_0000051 obo:RO_0002131 ), (obo:RO_0002131 obo:BFO_0000050 ) . obo:RO_0002132 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "The relation between a neuron projection bundle and a neuron projection that is fasciculated with it."@en ; obo:IAO_0000117 "David Osumi-Sutherland"@en ; obo:IAO_0000118 "has fasciculating component"@en ; obo:IAO_0000426 """(forall (?x ?y) (iff (has_fasciculating_neuron_projection ?x ?y) (exists (?nps ?npbs) (and (\"neuron projection bundle ; CARO_0001001\" ?x) (\"neuron projection ; GO0043005\" ?y) (\"neuron projection segment ; CARO_0001502\" ?nps) (\"neuron projection bundle segment ; CARO_0001500\" ?npbs) (part_of ?nps ?y) (part_of ?npbs ?x) (part_of ?nps ?npbs) (forall (?npbss) (if (and (\"neuron projection bundle subsegment ; CARO_0001501\" ?npbss) (part_of ?npbss ?npbs) ) (overlaps ?nps ?npbss) )))))) """^^xsd:string ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:domain obo:CARO_0001001 ; rdfs:label "has fasciculating neuron projection"@en ; rdfs:range [ a owl:Class ; owl:unionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000540 ] ) ] ; rdfs:subPropertyOf obo:RO_0002131 . obo:RO_0002134 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 """Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R."""@en ; obo:IAO_0000117 "David Osumi-Sutherland"@en ; obo:IAO_0000424 " some ( that ( some ( that some Y?)))" ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:domain obo:CARO_0001001 ; rdfs:label "innervates"@en ; rdfs:subPropertyOf owl:topObjectProperty ; owl:propertyChainAxiom (obo:RO_0002134 obo:BFO_0000050 ) . obo:RO_0002150 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "X continuous_with Y if and only if X and Y share a fiat boundary."^^xsd:string ; obo:IAO_0000117 "David Osumi-Sutherland" ; obo:IAO_0000118 "connected to" ; obo:IAO_0000232 "The label for this relation was previously connected to. I relabeled this to \"continuous with\". The standard notion of connectedness does not imply shared boundaries - e.g. Glasgow connected_to Edinburgh via M8; my patella connected_to my femur (via patellar-femoral joint)" ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "continuous with"@en ; rdfs:range obo:BFO_0000004 ; rdfs:seeAlso "FMA:85972" ; rdfs:subPropertyOf obo:RO_0002323 . obo:RO_0002151 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x partially overlaps y iff there exists some z such that z is part of x and z is part of y, and it is also the case that neither x is part of y or y is part of x" ; obo:IAO_0000116 "We would like to include disjointness axioms with part_of and has_part, however this is not possible in OWL2 as these are non-simple properties and hence cannot appear in a disjointness axiom" ; obo:IAO_0000118 "proper overlaps"^^xsd:string ; obo:IAO_0000426 """(forall (?x ?y) (iff (proper_overlaps ?x ?y) (and (overlaps ?x ?y) (not (part_of ?x ?y)) (not (part_of ?y ?x)))))"""^^xsd:string ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "partially overlaps"@en ; rdfs:subPropertyOf obo:RO_0002131 . obo:RO_0002156 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "d derived_by_descent_from a if d is specified by some genetic program that is sequence-inherited-from a genetic program that specifies a."^^xsd:string ; obo:IAO_0000118 "ancestral_stucture_of"^^xsd:string, "evolutionarily_descended_from"^^xsd:string ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "derived by descent from"^^xsd:string ; rdfs:subPropertyOf obo:RO_0002320 ; owl:inverseOf obo:RO_0002157 . obo:RO_0002157 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "inverse of derived by descent from" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "has derived by descendant"^^xsd:string ; rdfs:subPropertyOf obo:RO_0002320 . obo:RO_0002158 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "two individual entities d1 and d2 stand in a shares_ancestor_with relation if and only if there exists some a such that d1 derived_by_descent_from a and d2 derived_by_descent_from a."^^xsd:string ; obo:IAO_0000232 "Consider obsoleting and merging with child relation, 'in homology relationship with'" ; a owl:ObjectProperty, owl:SymmetricProperty, owl:TransitiveProperty ; rdfs:comment "VBO calls this homologous_to"^^xsd:string ; rdfs:label "shares ancestor with"^^xsd:string ; rdfs:subPropertyOf obo:RO_0002320 ; owl:propertyChainAxiom (obo:RO_0002156 obo:RO_0002157 ) . obo:RO_0002159 obo:IAO_0000114 obo:IAO_0000125 ; a owl:ObjectProperty, owl:SymmetricProperty, owl:TransitiveProperty ; rdfs:label "serially homologous to"^^xsd:string ; rdfs:subPropertyOf obo:RO_0002320 . obo:RO_0002160 obo:IAO_0000112 "lactation SubClassOf 'only in taxon' some 'Mammalia'" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z." ; obo:IAO_0000116 """The original intent was to treat this as a macro that expands to 'in taxon' only ?Y - however, this is not necessary if we instead have supplemental axioms that state that each pair of sibling tax have a disjointness axiom using the 'in taxon' property - e.g. 'in taxon' some Eukaryota DisjointWith 'in taxon' some Eubacteria""" ; obo:IAO_0000117 "Chris Mungall"@en ; obo:IAO_0000119 , ; a owl:ObjectProperty ; rdfs:label "only in taxon"^^xsd:string ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002162 . obo:RO_0002161 obo:IAO_0000112 "tooth SubClassOf 'never in taxon' value 'Aves'" ; obo:IAO_0000115 "x never in taxon T if and only if T is a class, and x does not instantiate the class expression \"in taxon some T\". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL." ; obo:IAO_0000117 "Chris Mungall"@en ; obo:IAO_0000119 , ; obo:IAO_0000425 "?X DisjointWith RO_0002162 some ?Y " ; a owl:AnnotationProperty ; rdfs:label "never in taxon"^^xsd:string ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002172 . obo:RO_0002162 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed." ; obo:IAO_0000117 "Chris Mungall"@en, "Jennifer Deegan" ; obo:IAO_0000119 , ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:comment "Connects a biological entity to its taxon of origin."^^xsd:string ; rdfs:label "in taxon"^^xsd:string ; rdfs:range obo:CARO_0001010 ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002320 ; owl:propertyChainAxiom (obo:BFO_0000050 obo:RO_0002162 ), (obo:BFO_0000051 obo:RO_0002162 ), (obo:RO_0002202 obo:RO_0002162 ), (obo:RO_0002206 obo:RO_0002162 ), (obo:RO_0002214 obo:RO_0002162 ), (obo:RO_0002215 obo:RO_0002162 ), (obo:RO_0002225 obo:RO_0002162 ), (obo:RO_0002254 obo:RO_0002162 ), (obo:RO_0002295 obo:RO_0002162 ) . obo:RO_0002163 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A is spatially_disjoint_from B if and only if they have no parts in common" ; obo:IAO_0000116 "There are two ways to encode this as a shortcut relation. The other possibility to use an annotation assertion between two classes, and expand this to a disjointness axiom. "@en ; obo:IAO_0000117 "Chris Mungall"@en ; obo:IAO_0000119 ; obo:IAO_0000232 "Note that it would be possible to use the relation to label the relationship between a near infinite number of structures - between the rings of saturn and my left earlobe. The intent is that this is used for parsiomoniously for disambiguation purposes - for example, between siblings in a jointly exhaustive pairwise disjointness hierarchy" ; obo:IAO_0000424 "BFO_0000051 exactly 0 (BFO_0000050 some ?Y)" ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "spatially disjoint from"^^xsd:string ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002323 . obo:RO_0002170 obo:IAO_0000112 "a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones)." ; obo:IAO_0000115 "a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b" ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:domain [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:RO_0002577 ] ; rdfs:label "connected to"@en ; rdfs:range [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:RO_0002577 ] ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern"^^xsd:anyURI, "https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002323 ; owl:propertyChainAxiom ([ owl:inverseOf obo:RO_0002176 ] obo:RO_0002176 ) . obo:RO_0002171 obo:IAO_0000115 "A is mutually_spatially_disjoint_with B if both A and B are classes, and there exists no p such that p is part_of some A and p is part_of some B." ; obo:IAO_0000118 "non-overlapping with", "shares no parts with" ; obo:IAO_0000119 ; obo:IAO_0000425 "Class: EquivalentTo: (BFO_0000050 some ?X) and (BFO_0000050 some ?Y)" ; a owl:AnnotationProperty ; rdfs:label "mutually spatially disjoint with"@en ; rdfs:seeAlso obo:RO_0002163, "https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002420 . obo:RO_0002172 obo:IAO_0000115 "An assertion that holds between an ontology class and an organism taxon class, which is intepreted to yield some relationship between instances of the ontology class and the taxon." ; a owl:AnnotationProperty ; rdfs:label "taxonomic class assertion"@en ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002420 . obo:RO_0002173 obo:IAO_0000115 "S ambiguous_for_taxon T if the class S does not have a clear referent in taxon T. An example would be the class 'manual digit 1', which encompasses a homology hypotheses that is accepted for some species (e.g. human and mouse), but does not have a clear referent in Aves - the referent is dependent on the hypothesis embraced, and also on the ontogenetic stage. [PHENOSCPAE:asilomar_mtg]" ; a owl:AnnotationProperty ; rdfs:label "ambiguous for taxon"@en ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002172 . obo:RO_0002174 obo:IAO_0000115 "S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T." ; obo:IAO_0000117 "https://orcid.org/0000-0002-6601-2165" ; obo:IAO_0000119 ; a owl:AnnotationProperty ; rdfs:comment "This relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take ongoing coordinated effort to resolve. Example: metencephalon in teleost" ; rdfs:label "dubious for taxon"@en ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002172 . obo:RO_0002175 obo:IAO_0000115 "S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S" ; obo:IAO_0000117 "https://orcid.org/0000-0002-6601-2165" ; obo:IAO_0000119 ; a owl:AnnotationProperty ; rdfs:label "present in taxon"@en ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002172 . obo:RO_0002176 obo:IAO_0000112 "The M8 connects Glasgow and Edinburgh", "a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones)." ; obo:IAO_0000115 "c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system." ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "connects"@en ; rdfs:range [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:RO_0002577 ] ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern"^^xsd:anyURI, "https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002323 . obo:RO_0002177 obo:IAO_0000115 "a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b." ; obo:IAO_0000589 "attached to part of (anatomical structure to anatomical structure)" ; a owl:ObjectProperty ; rdfs:domain obo:CARO_0000003 ; rdfs:label "attached to part of"@en ; rdfs:range obo:CARO_0000003 ; rdfs:subPropertyOf obo:RO_0002323, obo:RO_0002567 ; owl:propertyChainAxiom (obo:RO_0002371 obo:BFO_0000050 ) . obo:RO_0002178 obo:IAO_0000115 "Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy." ; obo:IAO_0000116 "Individual ontologies should provide their own constraints on this abstract relation. For example, in the realm of anatomy this should hold between an artery and an anatomical structure" ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "supplies"@en ; rdfs:subPropertyOf obo:RO_0002170 . obo:RO_0002179 obo:IAO_0000115 "Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure." ; obo:IAO_0000116 "Individual ontologies should provide their own constraints on this abstract relation. For example, in the realm of anatomy this should hold between a vein and an anatomical structure" ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "drains"@en ; rdfs:subPropertyOf obo:RO_0002170 . obo:RO_0002180 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." ; obo:IAO_0000116 "The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity." ; obo:IAO_0000232 "For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit."@en ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "has component"@en ; rdfs:seeAlso ; rdfs:subPropertyOf obo:BFO_0000051 . obo:RO_0002200 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype)." ; obo:IAO_0000117 "Chris Mungall"@en ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain [ a owl:Class ; owl:unionOf (obo:BFO_0000031 obo:CARO_0000006 obo:OGMS_0000031 ) ] ; rdfs:label "has phenotype"@en ; rdfs:range obo:UPHENO_0001001 ; rdfs:subPropertyOf owl:topObjectProperty ; owl:inverseOf obo:RO_0002201 . obo:RO_0002201 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "inverse of has phenotype" ; obo:IAO_0000117 "Chris Mungall"@en ; oboInOwl:inSubset obo:RO_0002259, subsets:ro-eco ; a owl:FunctionalProperty, owl:ObjectProperty ; rdfs:label "phenotype of"@en ; rdfs:subPropertyOf owl:topObjectProperty . obo:RO_0002202 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y" ; obo:IAO_0000117 "Chris Mungall"@en, "David Osumi-Sutherland"@en, "Melissa Haendel", "Terry Meehan"@en ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:comment "This is the transitive form of the develops from relation" ; rdfs:domain obo:BFO_0000004 ; rdfs:label "develops from"@en ; rdfs:range obo:BFO_0000004 ; rdfs:subPropertyOf obo:RO_0002258 ; owl:inverseOf obo:RO_0002203 . obo:RO_0002203 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "inverse of develops from" ; obo:IAO_0000117 "Chris Mungall"@en, "David Osumi-Sutherland"@en, "Terry Meehan"@en ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "develops into"@en ; rdfs:subPropertyOf obo:RO_0002286, obo:RO_0002387, obo:RO_0002388 . obo:RO_0002204 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "definition \"x has gene product of y if and only if y is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of that process is either y or something that is ribosomally translated from x\"" ; obo:IAO_0000116 "We would like to be able to express the rule: if t transcribed from g, and t is a noncoding RNA and has an evolved function, then t has gene product g." ; obo:IAO_0000117 "Chris Mungall"@en ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004, [ a owl:Class ; owl:unionOf (obo:BFO_0000031 obo:BFO_0000040 ) ] ; rdfs:label "gene product of"@en ; rdfs:range obo:BFO_0000002, [ a owl:Class ; owl:unionOf (obo:BFO_0000031 obo:BFO_0000040 ) ] ; rdfs:subPropertyOf obo:RO_0002330 ; owl:inverseOf obo:RO_0002205 ; owl:propertyChainAxiom (obo:RO_0002512 obo:RO_0002510 ) . obo:RO_0002205 obo:IAO_0000112 "every HOTAIR lncRNA is the gene product of some HOXC gene", "every sonic hedgehog protein (PR:000014841) is the gene product of some sonic hedgehog gene" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x has gene product y if and only if x is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of that process is either y or something that is ribosomally translated from y" ; obo:IAO_0000117 "Chris Mungall"@en ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000002 ; rdfs:label "has gene product"@en ; rdfs:range obo:BFO_0000004 ; rdfs:subPropertyOf obo:RO_0002330 ; owl:propertyChainAxiom (obo:RO_0002511 obo:RO_0002513 ) . obo:RO_0002206 obo:IAO_0000112 "'neural crest cell' SubClassOf expresses some 'Wnt1 gene'" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x expressed in y if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and the transcription of x is part of the gene expression process (iii) x is a mature gene product such as a protein, and x was translated or otherwise processes from a transcript that was transcribed as part of this gene expression process" ; obo:IAO_0000117 "Chris Mungall"@en ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000002, [ a owl:Class ; owl:unionOf (obo:BFO_0000031 obo:BFO_0000040 ) ] ; rdfs:label "expressed in"@en ; rdfs:range obo:CARO_0000006 ; rdfs:subPropertyOf obo:RO_0002330 ; owl:inverseOf obo:RO_0002292 ; owl:propertyChainAxiom (obo:RO_0002206 obo:BFO_0000050 ) . obo:RO_0002207 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y." ; obo:IAO_0000117 "Chris Mungall", "David Osumi-Sutherland", "has developmental precursor" ; obo:IAO_0000119 "FBbt" ; obo:RO_0002575 obo:RO_0002202 ; a owl:ObjectProperty ; rdfs:comment "TODO - add child relations from DOS" ; rdfs:domain [ a owl:Class ; owl:unionOf (obo:CARO_0010000 obo:CL_0000000 ) ] ; rdfs:label "directly develops from"@en ; rdfs:range [ a owl:Class ; owl:unionOf (obo:CARO_0010000 obo:CL_0000000 ) ] ; rdfs:subPropertyOf obo:RO_0002202 ; owl:inverseOf obo:RO_0002210 . obo:RO_0002208 obo:IAO_0000115 "A parasite that kills or sterilizes its host" ; a owl:ObjectProperty ; rdfs:label "parasitoid of" ; rdfs:subPropertyOf obo:RO_0002444 ; owl:inverseOf obo:RO_0002209 . obo:RO_0002209 obo:IAO_0000115 "inverse of parasitoid of" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "has parasitoid" ; rdfs:subPropertyOf obo:RO_0002445 . obo:RO_0002210 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "inverse of directly develops from" ; obo:IAO_0000118 "developmental precursor of" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "directly develops into"@en ; rdfs:subPropertyOf obo:RO_0002203 . obo:RO_0002211 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2." ; obo:IAO_0000116 "We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit" ; obo:IAO_0000117 "Chris Mungall", "David Hill", "Tanya Berardini" ; obo:IAO_0000119 , "GO" ; obo:IAO_0000232 "Regulation precludes parthood; the regulatory process may not be within the regulated process." ; obo:IAO_0000589 "regulates (processual)" ; obo:IAO_0000600 false ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "regulates"@en ; rdfs:range obo:BFO_0000015 ; rdfs:subPropertyOf obo:RO_0002411 ; owl:inverseOf obo:RO_0002334 ; owl:propertyChainAxiom (obo:RO_0002211 obo:RO_0002025 ), (obo:RO_0002230 obo:RO_0002211 ), (obo:RO_0002578 obo:RO_0002578 ) . obo:RO_0002212 obo:IAO_0000115 "Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2." ; obo:IAO_0000117 "Chris Mungall"@en ; obo:IAO_0000119 ; obo:IAO_0000589 "negatively regulates (process to process)" ; obo:RO_0004050 obo:RO_0002211 ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "negatively regulates"@en ; rdfs:subPropertyOf obo:RO_0002211, obo:RO_0002305 ; owl:inverseOf obo:RO_0002335 ; owl:propertyChainAxiom (obo:RO_0002230 obo:RO_0002212 ) . obo:RO_0002213 obo:IAO_0000115 "Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2." ; obo:IAO_0000117 "Chris Mungall"@en ; obo:IAO_0000119 ; obo:IAO_0000589 "positively regulates (process to process)" ; obo:RO_0004049 obo:RO_0002211 ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "positively regulates"@en ; rdfs:subPropertyOf obo:RO_0002211, obo:RO_0002304 ; owl:inverseOf obo:RO_0002336 ; owl:propertyChainAxiom (obo:RO_0002212 obo:RO_0002212 ), (obo:RO_0002230 obo:RO_0002213 ) . obo:RO_0002214 obo:IAO_0000112 "'human p53 protein' SubClassOf some ('has prototype' some ('participates in' some 'DNA repair'))", "heart SubClassOf 'has prototype' some ('participates in' some 'blood circulation')" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x has prototype y if and only if x is an instance of C and y is a prototypical instance of C. For example, every instance of heart, both normal and abnormal is related by the has prototype relation to some instance of a \"canonical\" heart, which participates in blood circulation." ; obo:IAO_0000116 "Experimental. In future there may be a formalization in which this relation is treated as a shortcut to some modal logic axiom. We may decide to obsolete this and adopt a more specific evolutionary relationship (e.g. evolved from)", "TODO: add homeomorphy axiom", "This property can be used to make weaker forms of certain relations by chaining an additional property. For example, we may say: retina SubClassOf has_prototype some 'detection of light'. i.e. every retina is related to a prototypical retina instance which is detecting some light. Note that this is very similar to 'capable of', but this relation affords a wider flexibility. E.g. we can make a relation between continuants." ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:domain [ a owl:Class ; owl:unionOf (obo:BFO_0000004 obo:BFO_0000015 ) ] ; rdfs:label "has prototype"@en . obo:RO_0002215 obo:IAO_0000112 "mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)", "osteoclast SubClassOf 'capable of' some 'bone resorption'" ; obo:IAO_0000115 "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "has function realized in" ; obo:IAO_0000119 , ; obo:IAO_0000232 "For compatibility with BFO, this relation has a shortcut definition in which the expression \"capable of some P\" expands to \"bearer_of (some realized_by only P)\"." ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "capable of"@en ; rdfs:range obo:BFO_0000015 ; rdfs:subPropertyOf obo:RO_0002216 . obo:RO_0002216 obo:IAO_0000115 "c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "has function in" ; a owl:ObjectProperty ; rdfs:label "capable of part of"@en ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002328, obo:RO_0002500 ; owl:propertyChainAxiom (obo:RO_0002215 obo:BFO_0000050 ) . obo:RO_0002217 obo:IAO_0000115 "OBSOLETE x actively participates in y if and only if x participates in y and x realizes some active role" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "agent in" ; a owl:ObjectProperty ; rdfs:comment "Obsoleted as the inverse property was obsoleted."^^xsd:string ; rdfs:label "obsolete actively participates in"@en ; owl:deprecated true . obo:RO_0002218 obo:IAO_0000112 "'heart development' has active participant some Shh protein" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x has participant y if and only if x realizes some active role that inheres in y" ; obo:IAO_0000116 "This may be obsoleted and replaced by the original 'has agent' relation" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "has agent" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "obsolete has active participant"^^xsd:string ; owl:deprecated true . obo:RO_0002219 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x" ; obo:IAO_0000117 "Chris Mungall" ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:label "surrounded by"@en ; rdfs:subPropertyOf obo:RO_0002220 ; owl:inverseOf obo:RO_0002221 . obo:RO_0002220 obo:IAO_0000112 "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts.", "The epidermis layer of a vertebrate is adjacent to the dermis.", "The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies.", "The skin of the forelimb is adjacent to the skin of the torso if these are considered anatomical subdivisions with a defined border. Otherwise a relation such as continuous_with would be used." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x adjacent to y if and only if x and y share a boundary." ; obo:IAO_0000116 "This relation acts as a join point with BSPO" ; obo:IAO_0000117 "Chris Mungall" ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "adjacent to"@en ; rdfs:range obo:BFO_0000004 ; rdfs:subPropertyOf obo:RO_0002163 . obo:RO_0002221 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "inverse of surrounded by" ; obo:IAO_0000117 "Chris Mungall" ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "surrounds"@en ; rdfs:subPropertyOf obo:RO_0002220 . obo:RO_0002222 obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends." ; terms:source "https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1"^^xsd:anyURI ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty . obo:RO_0002223 obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; rdfs:subPropertyOf obo:BFO_0000050 . obo:RO_0002224 obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; rdfs:subPropertyOf obo:BFO_0000051 . obo:RO_0002225 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x develops from part of y if and only if there exists some z such that x develops from z and z is part of y" ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "develops from part of"@en ; rdfs:subPropertyOf obo:RO_0002202 ; owl:propertyChainAxiom (obo:RO_0002207 obo:BFO_0000050 ) . obo:RO_0002226 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x develops_in y if x is located in y whilst x is developing" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "EHDAA2", "Jonathan Bard, EHDAA2" ; a owl:ObjectProperty ; rdfs:domain obo:CARO_0000000 ; rdfs:label "develops in"@en ; rdfs:subPropertyOf obo:RO_0002258 ; owl:propertyChainAxiom (obo:RO_0002207 obo:RO_0001025 ) . obo:RO_0002227 obo:IAO_0000115 "A sub-relation of parasite-of in which the parasite that cannot complete its life cycle without a host." ; a owl:ObjectProperty ; rdfs:label "obligate parasite of" ; rdfs:subPropertyOf obo:RO_0002444 . obo:RO_0002228 obo:IAO_0000115 "A sub-relations of parasite-of in which the parasite that can complete its life cycle independent of a host." ; a owl:ObjectProperty ; rdfs:label "facultative parasite of" ; rdfs:subPropertyOf obo:RO_0002444 . obo:RO_0002229 obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; rdfs:subPropertyOf obo:BFO_0000050 . obo:RO_0002230 obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; rdfs:subPropertyOf obo:BFO_0000051 . obo:RO_0002231 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "starts with process that occurs in" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "has start location"@en ; rdfs:range obo:BFO_0000004 ; rdfs:subPropertyOf obo:RO_0002479 ; owl:propertyChainAxiom (obo:RO_0002224 obo:BFO_0000066 ) . obo:RO_0002232 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "ends with process that occurs in" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "has end location"@en ; rdfs:range obo:BFO_0000004 ; rdfs:subPropertyOf obo:RO_0002479 ; owl:propertyChainAxiom (obo:RO_0002230 obo:BFO_0000066 ) . obo:RO_0002233 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "consumes" ; oboInOwl:inSubset subsets:ro-eco, obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "has input"@en ; rdfs:subPropertyOf obo:RO_0000057 ; owl:inverseOf obo:RO_0002352 ; owl:propertyChainAxiom (obo:RO_0002224 obo:RO_0002233 ) . obo:RO_0002234 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "p has output c iff c is a participant in p, c is present at the end of p, and c is not present at the beginning of p." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "produces" ; oboInOwl:inSubset subsets:ro-eco, obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "has output"@en ; rdfs:subPropertyOf obo:RO_0000057 ; owl:inverseOf obo:RO_0002353 ; owl:propertyChainAxiom (obo:RO_0002230 obo:RO_0002234 ) . obo:RO_0002235 obo:IAO_0000115 "A parasite-of relationship in which the host is a plant and the parasite that attaches to the host stem (PO:0009047)" ; a owl:ObjectProperty ; rdfs:label "stem parasite of" ; rdfs:subPropertyOf obo:RO_0002444 . obo:RO_0002236 obo:IAO_0000115 "A parasite-of relationship in which the host is a plant and the parasite that attaches to the host root (PO:0009005)" ; a owl:ObjectProperty ; rdfs:label "root parasite of" ; rdfs:subPropertyOf obo:RO_0002444 . obo:RO_0002237 obo:IAO_0000115 "A sub-relation of parasite-of in which the parasite is a plant, and the parasite is parasitic under natural conditions and is also photosynthetic to some degree. Hemiparasites may just obtain water and mineral nutrients from the host plant. Many obtain at least part of their organic nutrients from the host as well." ; a owl:ObjectProperty ; rdfs:label "hemiparasite of" ; rdfs:subPropertyOf obo:RO_0002444 . obo:RO_0002240 obo:IAO_0000115 "A broad relationship between an exposure event or process and any entity (e.g., an organism, organism population, or an organism part) that interacts with an exposure stimulus during the exposure event." ; obo:IAO_0000119 "ExO:0000001" ; a owl:ObjectProperty ; rdfs:label "has exposure receptor" ; rdfs:subPropertyOf obo:RO_0002244 . obo:RO_0002241 obo:IAO_0000115 "A broad relationship between an exposure event or process and any agent, stimulus, activity, or event that causes stress or tension on an organism and interacts with an exposure receptor during an exposure event." ; obo:IAO_0000119 "ExO:0000000" ; a owl:ObjectProperty ; rdfs:label "has exposure stressor" ; rdfs:subPropertyOf obo:RO_0002309 . obo:RO_0002242 obo:IAO_0000115 "A broad relationship between an exposure event or process and a process by which the exposure stressor comes into contact with the exposure receptor" ; obo:IAO_0000119 "ExO:0000055" ; a owl:ObjectProperty ; rdfs:label "has exposure route" ; rdfs:subPropertyOf obo:RO_0002244 . obo:RO_0002243 obo:IAO_0000115 "A broad relationship between an exposure event or process and the course takes from the source to the target." ; obo:IAO_0000119 "http://purl.obolibrary.org/obo/ExO_0000004"^^xsd:anyURI ; a owl:ObjectProperty ; rdfs:label "has exposure transport path" ; rdfs:subPropertyOf obo:RO_0002244 . obo:RO_0002244 obo:IAO_0000115 "Any relationship between an exposure event or process and any other entity." ; obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving exposure events or processes." ; a owl:ObjectProperty ; rdfs:domain obo:RO_0002310 ; rdfs:label "related via exposure to" ; rdfs:subPropertyOf obo:RO_0002410 . obo:RO_0002245 obo:IAO_0000115 "g is over-expressed in t iff g is expressed in t, and the expression level of g is increased relative to some background." ; a owl:ObjectProperty ; rdfs:label "over-expressed in" ; rdfs:subPropertyOf obo:RO_0002206 . obo:RO_0002246 obo:IAO_0000115 "g is under-expressed in t iff g is expressed in t, and the expression level of g is decreased relative to some background." ; a owl:ObjectProperty ; rdfs:label "under-expressed in" ; rdfs:subPropertyOf obo:RO_0002206 . obo:RO_0002248 obo:IAO_0000112 "Any portion of roundup 'has active ingredient' some glyphosate" ; obo:IAO_0000115 "A relationship that holds between a substance and a chemical entity, if the chemical entity is part of the substance, and the chemical entity forms the biologically active component of the substance." ; oboInOwl:hasExactSynonym "has active substance" ; oboInOwl:hasRelatedSynonym "has active pharmaceutical ingredient" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "has active ingredient" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:BFO_0000051 ; owl:inverseOf obo:RO_0002249 . obo:RO_0002249 obo:IAO_0000115 "inverse of has active ingredient" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "active ingredient in" ; rdfs:subPropertyOf obo:BFO_0000050 . obo:RO_0002252 obo:IAO_0000115 "b connecting-branch-of s iff b is connected to s, and there exists some tree-like structure t such that the mereological sum of b plus s is either the same as t or a branching-part-of t." ; a owl:ObjectProperty ; rdfs:label "connecting branch of" ; rdfs:subPropertyOf obo:RO_0002375 ; owl:inverseOf obo:RO_0002253 . obo:RO_0002253 obo:IAO_0000115 "inverse of connecting branch of" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "has connecting branch" ; rdfs:subPropertyOf obo:RO_0002375 . obo:RO_0002254 obo:IAO_0000112 "Mammalian thymus has developmental contribution from some pharyngeal pouch 3; Mammalian thymus has developmental contribution from some pharyngeal pouch 4 [Kardong]" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x has developmental contribution from y iff x has some part z such that z develops from y"@en ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:domain obo:CARO_0000000 ; rdfs:label "has developmental contribution from"@en ; rdfs:range obo:CARO_0000000 ; rdfs:subPropertyOf obo:RO_0002258 ; owl:inverseOf obo:RO_0002255 ; owl:propertyChainAxiom (obo:BFO_0000051 obo:RO_0002202 ) . obo:RO_0002255 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "inverse of has developmental contribution from" ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "developmentally contributes to"@en ; rdfs:subPropertyOf obo:RO_0002286, obo:RO_0002385 ; owl:propertyChainAxiom (obo:RO_0002203 obo:BFO_0000050 ) . obo:RO_0002256 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor anatomical structure type T to T', where T' develops_from T" ; obo:IAO_0000117 "Chris Mungall", "David Osumi-Sutherland", "Melissa Haendel" ; obo:IAO_0000118 "induced by" ; obo:IAO_0000119 , " Developmental Biology, Gilbert, 8th edition, figure 6.5(F)", "GO:0001759" ; obo:IAO_0000232 "We place this under 'developmentally preceded by'. This placement should be examined in the context of reciprocal inductions[cjm]" ; a owl:ObjectProperty ; rdfs:domain obo:CARO_0000003 ; rdfs:label "developmentally induced by"@en ; rdfs:range obo:CARO_0000003 ; rdfs:subPropertyOf obo:RO_0002258 ; owl:inverseOf obo:RO_0002257 . obo:RO_0002257 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Inverse of developmentally induced by"@en ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "developmentally induces"@en ; rdfs:subPropertyOf obo:RO_0002286, obo:RO_0002386 . obo:RO_0002258 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p" ; obo:IAO_0000116 false ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "In general you should not use this relation to make assertions - use one of the more specific relations below this one" ; a owl:ObjectProperty ; rdfs:comment "This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from" ; rdfs:domain obo:BFO_0000002 ; rdfs:label "developmentally preceded by"@en ; rdfs:range obo:BFO_0000002 ; rdfs:subPropertyOf obo:RO_0002324 ; owl:inverseOf obo:RO_0002286 . obo:RO_0002259 a owl:AnnotationProperty ; rdfs:label "defined by inverse" ; rdfs:subPropertyOf oboInOwl:SubsetProperty . obo:RO_0002260 a owl:ObjectProperty . obo:RO_0002261 a owl:ObjectProperty . obo:RO_0002262 a owl:ObjectProperty . obo:RO_0002263 obo:IAO_0000112 "A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision." ; obo:IAO_0000115 "c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes." ; oboInOwl:inSubset obo:valid_for_go_gp2term ; a owl:ObjectProperty ; rdfs:label "acts upstream of" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002264 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002411 ) . obo:RO_0002264 obo:IAO_0000112 "A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway." ; obo:IAO_0000115 "c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process." ; oboInOwl:hasRelatedSynonym "affects" ; oboInOwl:inSubset obo:valid_for_go_gp2term ; a owl:ObjectProperty ; rdfs:label "acts upstream of or within" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002500 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002418 ) . obo:RO_0002285 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else" ; obo:IAO_0000116 "This relation is intended for cases such as when we have a bone element replacing its cartilage element precursor. Currently most AOs represent this using 'develops from'. We need to decide whether 'develops from' will be generic and encompass replacement, or whether we need a new name for a generic relation that encompasses replacement and development-via-cell-lineage" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "replaces" ; a owl:ObjectProperty ; rdfs:label "developmentally replaces"@en ; rdfs:subPropertyOf obo:RO_0002258 . obo:RO_0002286 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Inverse of developmentally preceded by" ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "developmentally succeeded by"@en ; rdfs:subPropertyOf obo:RO_0002384 . obo:RO_0002287 obo:IAO_0000112 "'hypopharyngeal eminence' SubClassOf 'part of precursor of' some tongue" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "part of developmental precursor of"@en ; rdfs:subPropertyOf obo:RO_0002286 ; owl:propertyChainAxiom (obo:BFO_0000050 obo:RO_0002210 ) . obo:RO_0002291 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x is ubiquitously expressed in y if and only if x is expressed in y, and the majority of cells in y express x" ; obo:IAO_0000116 "Revisit this term after coordinating with SO/SOM. The domain of this relation should be a sequence, as an instance of a DNA molecule is only expressed in the cell of which it is a part." ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "ubiquitously expressed in"@en ; rdfs:subPropertyOf obo:RO_0002206 ; owl:inverseOf obo:RO_0002293 . obo:RO_0002292 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Inverse of 'expressed in'" ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "expresses"@en ; rdfs:subPropertyOf obo:RO_0002330 . obo:RO_0002293 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "inverse of ubiquiotously expressed in" ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "ubiquitously expresses"@en ; rdfs:subPropertyOf obo:RO_0002292 . obo:RO_0002295 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "p results in the developmental progression of s iff p is a developmental process and s is an anatomical structure and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss)." ; obo:IAO_0000116 "This property and its subproperties are being used primarily for the definition of GO developmental processes. The property hierarchy mirrors the core GO hierarchy. In future we may be able to make do with a more minimal set of properties, but due to the way GO is currently structured we require highly specific relations to avoid incorrect entailments. To avoid this, the corresponding genus terms in GO should be declared mutually disjoint." ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:shorthand "results_in_developmental_progression_of"^^xsd:string ; a owl:ObjectProperty ; rdfs:domain obo:GO_0008150 ; rdfs:label "results in developmental progression of"@en ; rdfs:range obo:CARO_0000003 ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002324 . obo:RO_0002296 obo:IAO_0000112 "every flower development (GO:0009908) results in development of some flower (PO:0009046)"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "p 'results in development of' c if and only if p is a developmental process and p results in the state of c changing from its initial state as a primordium or anlage through its mature state and to its final state." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.geneontology.org/GO.doc.development.shtml"^^xsd:anyURI ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; oboInOwl:shorthand "results_in_development_of"^^xsd:string ; a owl:ObjectProperty ; rdfs:label "results in development of"@en ; rdfs:subPropertyOf obo:RO_0002295, obo:RO_0040036 . obo:RO_0002297 obo:IAO_0000112 "an annotation of gene X to anatomical structure formation with results_in_formation_of UBERON:0000007 (pituitary gland) means that at the beginning of the process a pituitary gland does not exist and at the end of the process a pituitary gland exists.", "every \"endocardial cushion formation\" (GO:0003272) results_in_formation_of some \"endocardial cushion\" (UBERON:0002062)"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "GOC:mtg_berkeley_2013" ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; oboInOwl:shorthand "results_in_formation_of"^^xsd:string ; a owl:ObjectProperty ; rdfs:label "results in formation of"@en ; rdfs:subPropertyOf obo:RO_0002234, obo:RO_0002295 ; owl:inverseOf obo:RO_0002354 . obo:RO_0002298 obo:IAO_0000112 "an annotation of gene X to cell morphogenesis with results_in_morphogenesis_of CL:0000540 (neuron) means that at the end of the process an input neuron has attained its shape.", "tongue morphogenesis (GO:0043587) results in morphogenesis of tongue (UBERON:0001723)"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "GOC:mtg_berkeley_2013" ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; oboInOwl:shorthand "results_in_morphogenesis_of"^^xsd:string ; a owl:ObjectProperty ; rdfs:label "results in morphogenesis of"@en ; rdfs:subPropertyOf obo:RO_0002295, obo:RO_0040036 . obo:RO_0002299 obo:IAO_0000112 " an annotation of gene X to cell maturation with results_in_maturation_of CL:0000057 (fibroblast) means that the fibroblast is mature at the end of the process", "bone maturation (GO:0070977) results_in_maturation_of bone (UBERON:0001474)"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "The relationship that links an entity with a process that results in the progression of the entity over time that is independent of changes in it's shape and results in an end point state of that entity." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "GOC:mtg_berkeley_2013" ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; oboInOwl:shorthand "results_in_maturation_of"^^xsd:string ; a owl:ObjectProperty ; rdfs:label "results in maturation of"@en ; rdfs:subPropertyOf obo:RO_0002295, obo:RO_0040036 . obo:RO_0002300 obo:IAO_0000112 "foramen ovale closure SubClassOf results in disappearance of foramen ovale" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "May be merged into parent relation" ; oboInOwl:shorthand "results_in_disappearance_of"^^xsd:string ; a owl:ObjectProperty ; rdfs:label "results in disappearance of"@en ; rdfs:subPropertyOf obo:RO_0002552 . obo:RO_0002301 obo:IAO_0000112 "every mullerian duct regression (GO:0001880) results in regression of some mullerian duct (UBERON:0003890)" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "May be merged into parent relation" ; a owl:ObjectProperty ; rdfs:label "results in developmental regression of"@en ; rdfs:subPropertyOf obo:RO_0002552 . obo:RO_0002302 obo:IAO_0000115 "Inverse of 'is substance that treats'" ; terms:creator "cjm"^^xsd:string ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "is treated by substance" ; rdfs:subPropertyOf obo:RO_0002410 ; owl:inverseOf obo:RO_0002606 . obo:RO_0002303 obo:IAO_0000112 """Hydrozoa (NCBITaxon_6074) SubClassOf 'has habitat' some 'Hydrozoa habitat' where 'Hydrozoa habitat' SubClassOf overlaps some ('marine environment' (ENVO_00000569) and 'freshwater environment' (ENVO_01000306) and 'wetland' (ENVO_00000043)) and 'has part' some (freshwater (ENVO_00002011) or 'sea water' (ENVO_00002149)) -- http://eol.org/pages/1795/overview""" ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x 'has habitat' y if and only if: x is an organism, y is a habitat, and y can sustain and allow the growth of a population of xs." ; obo:IAO_0000117 "Pier Buttigieg" ; obo:IAO_0000118 "adapted for living in" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:comment "A population of xs will possess adaptations (either evolved naturally or via artifical selection) which permit it to exist and grow in y." ; rdfs:domain obo:CARO_0001010 ; rdfs:label "has habitat"@en ; rdfs:range obo:ENVO_01000254 ; rdfs:subPropertyOf obo:RO_0002321 . obo:RO_0002304 obo:RO_0004049 obo:RO_0002411 ; terms:creator "cjm"^^xsd:string ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:comment "holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y" ; rdfs:label "causally upstream of, positive effect" ; rdfs:subPropertyOf obo:RO_0002411, obo:RO_0004047 . obo:RO_0002305 obo:RO_0004050 obo:RO_0002411 ; terms:creator "cjm"^^xsd:string ; a owl:ObjectProperty ; rdfs:comment "holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y" ; rdfs:label "causally upstream of, negative effect" ; rdfs:subPropertyOf obo:RO_0002411, obo:RO_0004046 . obo:RO_0002309 obo:IAO_0000115 "A relationship between an exposure event or process and any agent, stimulus, activity, or event that causally effects an organism and interacts with an exposure receptor during an exposure event." ; terms:contributor "Austin Meier", "Chris Mungall", "Marie Angelique Laporte" ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-06-05T17:35:04Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "has exposure stimulus" ; rdfs:subPropertyOf obo:RO_0002244 . obo:RO_0002310 obo:IAO_0000112 "An exposure event in which a human is exposed to particulate matter in the air. Here the exposure stimulus/stress is the particulate matter, the receptor is the airways and lungs of the human,", "An exposure event in which a plant is provided with fertilizer. The exposure receptor is the root system of the plant, the stimulus is the fertilizing chemical, the route is via the soil, possibly mediated by symbotic microbes."^^xsd:anyURI ; obo:IAO_0000115 "A process occurring within or in the vicinity of an organism that exerts some causal influence on the organism via the interaction between an exposure stimulus and an exposure receptor. The exposure stimulus may be a process, material entity or condition (for example, lack of nutrients). The exposure receptor can be an organism, organism population or a part of an organism." ; obo:IAO_0000116 "This class is intended as a grouping for various domain and species-specific exposure classes. The ExO class http://purl.obolibrary.org/obo/ExO_0000002 'exposure event' assumes that all exposures involve stressors, which limits the applicability of this class to 'positive' exposures, e.g. exposing a plant to beneficial growing conditions." ; terms:creator "Chris Mungall" ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-06-05T17:55:39Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "exposure event or process" ; rdfs:seeAlso "https://github.com/oborel/obo-relations/pull/173"^^xsd:anyURI ; rdfs:subClassOf obo:BFO_0000015 . obo:RO_0002312 obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "evolutionary variant of"@en ; rdfs:subPropertyOf obo:RO_0002320 . obo:RO_0002313 obo:IAO_0000115 "Holds between p and c when p is a localization process (localization covers maintenance of localization as well as its establishment) and the outcome of this process is to regulate the localization of c." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "regulates localization of" ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "transports or maintains localization of"@en ; rdfs:subPropertyOf obo:RO_0002337, obo:RO_0040036 . obo:RO_0002314 obo:IAO_0000115 "q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w." ; obo:IAO_0000116 "Because part_of is transitive, inheres in is a sub-relation of characteristic of part of" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "inheres in part of" ; obo:IAO_0000119 ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:label "characteristic of part of"@en ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002502 ; owl:propertyChainAxiom (obo:RO_0000052 obo:BFO_0000050 ), (obo:RO_0002314 obo:BFO_0000050 ) . obo:RO_0002315 obo:IAO_0000112 "an annotation of gene X to cell differentiation with results_in_maturation_of CL:0000057 (fibroblast) means that at the end of the process the input cell that did not have features of a fibroblast, now has the features of a fibroblast." ; obo:IAO_0000115 "The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "GOC:mtg_berkeley_2013" ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; oboInOwl:shorthand "results_in_acquisition_of_features_of"^^xsd:string ; a owl:ObjectProperty ; rdfs:label "results in acquisition of features of"@en ; rdfs:range obo:CARO_0000003 ; rdfs:subPropertyOf obo:RO_0002295, obo:RO_0040036 . obo:RO_0002320 obo:IAO_0000115 "A relationship that holds via some environmental process" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the process of evolution." ; a owl:ObjectProperty ; rdfs:label "evolutionarily related to"@en . obo:RO_0002321 obo:IAO_0000115 "A relationship that is mediated in some way by the environment or environmental feature (ENVO:00002297)" ; obo:IAO_0000116 "Awaiting class for domain/range constraint, see: https://github.com/OBOFoundry/Experimental-OBO-Core/issues/6" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving ecological interactions" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "ecologically related to"@en . obo:RO_0002322 obo:IAO_0000116 "An experimental relation currently used to connect a feature possessed by an organism (e.g. anatomical structure, biological process, phenotype or quality) to a habitat or environment in which that feature is well suited, adapted or provides a reproductive advantage for the organism. For example, fins to an aquatic environment. Usually this will mean that the structure is adapted for this environment, but we avoid saying this directly - primitive forms of the structure may not have evolved specifically for that environment (for example, early wings were not necessarily adapted for an aerial environment). Note also that this is a statement about the general class of structures - not every instance of a limb need confer an advantage for a terrestrial environment, e.g. if the limb is vestigial." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "adapted for" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "confers advantage in"@en ; rdfs:range obo:ENVO_01000254 ; rdfs:subPropertyOf obo:RO_0002321 . obo:RO_0002323 obo:IAO_0000115 "A mereological relationship or a topological relationship" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships" ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:label "mereotopologically related to"@en . obo:RO_0002324 obo:IAO_0000115 "A relationship that holds between entities participating in some developmental process (GO:0032502)" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving organismal development" ; a owl:ObjectProperty ; rdfs:label "developmentally related to"@en . obo:RO_0002325 obo:IAO_0000112 "Clp1p relocalizes from the nucleolus to the spindle and site of cell division; i.e. it is associated transiently with the spindle pole body and the contractile ring (evidence from GFP fusion). Clp1p colocalizes_with spindle pole body (GO:0005816) and contractile ring (GO:0005826)" ; obo:IAO_0000115 "a colocalizes_with b if and only if a is transiently or peripherally associated with b[GO]." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.geneontology.org/GO.annotation.conventions.shtml#colocalizes_with" ; obo:IAO_0000232 "In the context of the Gene Ontology, colocalizes_with may be used for annotating to cellular component terms[GO]" ; terms:creator "Gene Ontology Consortium" ; oboInOwl:inSubset obo:valid_for_go_gp2term ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "colocalizes with"@en ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0002323 . obo:RO_0002326 obo:IAO_0000112 "ATP citrate lyase (ACL) in Arabidopsis: it is a heterooctamer, composed of two types of subunits, ACLA and ACLB in a A(4)B(4) stoichiometry. Neither of the subunits expressed alone give ACL activity, but co-expression results in ACL activity. Both subunits contribute_to the ATP citrate lyase activity.", "Subunits of nuclear RNA polymerases: none of the individual subunits have RNA polymerase activity, yet all of these subunits contribute_to DNA-dependent RNA polymerase activity.", "eIF2: has three subunits (alpha, beta, gamma); one binds GTP; one binds RNA; the whole complex binds the ribosome (all three subunits are required for ribosome binding). So one subunit is annotated to GTP binding and one to RNA binding without qualifiers, and all three stand in the contributes_to relationship to \"ribosome binding\". And all three are part_of an eIF2 complex" ; obo:IAO_0000116 """We would like to say if and only if exists c', p' c part_of c' and c' capable_of p and c capable_of p' and p' part_of p then c contributes_to p However, this is not possible in OWL. We instead make this relation a sub-relation of the two chains, which gives us the inference in the one direction.""" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.geneontology.org/GO.annotation.conventions.shtml#contributes_to" ; obo:IAO_0000232 "In the context of the Gene Ontology, contributes_to may be used only with classes from the molecular function ontology. " ; oboInOwl:inSubset obo:valid_for_go_gp2term ; a owl:ObjectProperty ; rdfs:label "contributes to"@en ; rdfs:subPropertyOf obo:RO_0002216, obo:RO_0002329 . obo:RO_0002327 obo:IAO_0000112 "a particular instances of akt-2 enables some instance of protein kinase activity" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "catalyzes", "executes", "has", "is catalyzing", "is executing" ; obo:IAO_0000232 "This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized.", "This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time." ; oboInOwl:inSubset obo:valid_for_go_gp2term ; a owl:ObjectProperty ; rdfs:label "enables"@en ; rdfs:subPropertyOf obo:RO_0002215 ; owl:inverseOf obo:RO_0002333 ; owl:propertyChainAxiom (obo:RO_0002327 obo:BFO_0000051 ), (obo:RO_0002327 obo:RO_0002017 ) . obo:RO_0002328 obo:IAO_0000115 "A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "This is a grouping relation that collects relations used for the purpose of connecting structure and function" ; a owl:ObjectProperty ; rdfs:label "functionally related to"@en . obo:RO_0002329 obo:IAO_0000115 "this relation holds between c and p when c is part of some c', and c' is capable of p." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 false ; a owl:ObjectProperty ; rdfs:label "part of structure that is capable of"@en ; rdfs:subPropertyOf obo:RO_0002328 ; owl:propertyChainAxiom (obo:BFO_0000050 obo:RO_0002215 ) . obo:RO_0002330 obo:IAO_0000115 "holds between two entities when some genome-level process such as gene expression is involved. This includes transcriptional, spliceosomal events. These relations can be used between either macromolecule entities (such as regions of nucleic acid) or between their abstract informational counterparts." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving the genome of an organism" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000002 ; rdfs:label "genomically related to"@en ; rdfs:range obo:BFO_0000002 . obo:RO_0002331 obo:IAO_0000115 "c involved_in p if and only if c enables some process p', and p' is part of p" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "actively involved in", "enables part of" ; a owl:ObjectProperty ; rdfs:label "involved in"@en ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0000056, obo:RO_0002431 ; owl:propertyChainAxiom (obo:RO_0002327 obo:BFO_0000050 ), (obo:RO_0002331 obo:BFO_0000050 ) . obo:RO_0002332 obo:IAO_0000112 "every cellular sphingolipid homeostasis process regulates_level_of some sphingolipid" ; obo:IAO_0000115 "p regulates levels of c if p regulates some amount (PATO:0000070) of c" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 ; obo:IAO_0000589 "regulates levels of (process to entity)" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "regulates levels of"@en ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0002328 . obo:RO_0002333 obo:IAO_0000115 "inverse of enables" ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "enabled by"@en ; rdfs:subPropertyOf obo:RO_0000057, obo:RO_0002328 . obo:RO_0002334 obo:IAO_0000115 "inverse of regulates" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000589 "regulated by (processual)" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "regulated by"@en ; rdfs:range obo:BFO_0000015 ; rdfs:subPropertyOf obo:RO_0002427 . obo:RO_0002335 obo:IAO_0000115 "inverse of negatively regulates" ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "negatively regulated by"@en ; rdfs:subPropertyOf obo:RO_0002334 . obo:RO_0002336 obo:IAO_0000115 "inverse of positively regulates" ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "positively regulated by"@en ; rdfs:subPropertyOf obo:RO_0002334 . obo:RO_0002337 obo:IAO_0000115 "A relationship that holds via some process of localization" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "Do not use this relation directly. It is a grouping relation." ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "related via localization to"@en ; rdfs:range obo:BFO_0000002 . obo:RO_0002338 obo:IAO_0000115 "This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination." ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "has target start location"@en ; rdfs:subPropertyOf obo:RO_0002344 ; owl:propertyChainAxiom (obo:RO_0002338 obo:BFO_0000050 ) . obo:RO_0002339 obo:IAO_0000115 "This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l." ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "has target end location"@en ; rdfs:subPropertyOf obo:RO_0002344 ; owl:propertyChainAxiom (obo:RO_0002339 obo:BFO_0000050 ) . obo:RO_0002340 obo:IAO_0000115 "Holds between p and c when p is a transportation or localization process and the outcome of this process is to move c to a destination that is part of some s, where the start location of c is part of the region that surrounds s." ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset obo:valid_for_go_ontology ; a owl:ObjectProperty ; rdfs:label "imports"@en ; rdfs:subPropertyOf obo:RO_0002020 . obo:RO_0002341 obo:IAO_0000115 "Holds between p and l when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that is aligned_with l " ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "results in transport along"@en ; rdfs:subPropertyOf obo:RO_0002337 . obo:RO_0002342 obo:IAO_0000115 "Holds between p and m when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that crosses m." ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset obo:valid_for_go_ontology ; a owl:ObjectProperty ; rdfs:label "results in transport across"@en ; rdfs:subPropertyOf obo:RO_0002021, obo:RO_0002344 . obo:RO_0002343 obo:IAO_0000112 "'pollen tube growth' results_in growth_of some 'pollen tube'" ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "results in growth of"@en ; rdfs:subPropertyOf obo:RO_0002295, obo:RO_0040036 . obo:RO_0002344 obo:IAO_0000112 "'mitochondrial transport' results_in_transport_to_from_or_in some mitochondrion (GO:0005739)" ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "results in transport to from or in"@en ; rdfs:subPropertyOf obo:RO_0002337 . obo:RO_0002345 obo:IAO_0000115 "Holds between p and c when p is a transportation or localization process and the outcome of this process is to move c to a destination that is part of some s, where the end location of c is part of the region that surrounds s."^^xsd:string ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset obo:valid_for_go_ontology ; a owl:ObjectProperty ; rdfs:label "exports"@en ; rdfs:subPropertyOf obo:RO_0002020 . obo:RO_0002348 obo:IAO_0000112 "an annotation of gene X to cell commitment with results_in_commitment_to CL:0000540 (neuron) means that at the end of the process an unspecified cell has been specified and determined to develop into a neuron." ; obo:IAO_0000115 "p 'results in commitment to' c if and only if p is a developmental process and c is a cell and p results in the state of c changing such that is can only develop into a single cell type." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.geneontology.org/GO.doc.development.shtml#fate"^^xsd:anyURI ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "results in commitment to"@en ; rdfs:range obo:CL_0000000 ; rdfs:subPropertyOf obo:RO_0002295 . obo:RO_0002349 obo:IAO_0000115 "p 'results in determination of' c if and only if p is a developmental process and c is a cell and p results in the state of c changing to be determined. Once a cell becomes determined, it becomes committed to differentiate down a particular pathway regardless of its environment." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.geneontology.org/GO.doc.development.shtml#fate"^^xsd:anyURI ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "results in determination of"@en ; rdfs:range obo:CL_0000000 ; rdfs:subPropertyOf obo:RO_0002295 . obo:RO_0002352 obo:IAO_0000115 "inverse of has input" ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset obo:RO_0002259, subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "input of"@en ; rdfs:subPropertyOf obo:RO_0000056, obo:RO_0002328 . obo:RO_0002353 obo:IAO_0000115 "inverse of has output" ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset obo:RO_0002259, subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "output of"@en ; rdfs:subPropertyOf obo:RO_0000056, obo:RO_0002328 . obo:RO_0002354 obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "formed as result of"@en ; rdfs:subPropertyOf obo:RO_0002353 . obo:RO_0002355 obo:IAO_0000115 "A relationship between a process and an anatomical entity such that the process contributes to the act of creating the structural organization of the anatomical entity." ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "results in structural organization of"@en ; rdfs:subPropertyOf obo:RO_0002295, obo:RO_0040036 . obo:RO_0002356 obo:IAO_0000115 "The relationship linking a cell and its participation in a process that results in the fate of the cell being specified. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. " ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.geneontology.org/GO.doc.development.shtml#fate"^^xsd:anyURI ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "results in specification of"@en ; rdfs:range obo:CL_0000000 ; rdfs:subPropertyOf obo:RO_0002295 . obo:RO_0002357 obo:IAO_0000115 "p results in developmental induction of c if and only if p is a collection of cell-cell signaling processes that signal to a neighbouring tissue that is the precursor of the mature c, where the signaling results in the commitment to cell types necessary for the formation of c." ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "results in developmental induction of"@en ; rdfs:subPropertyOf obo:RO_0002295 . obo:RO_0002360 obo:IAO_0000117 "Chris Mungall" ; terms:source "http://neurolex.org/wiki/Property:DendriteLocation"^^xsd:anyURI ; a owl:ObjectProperty ; rdfs:label "has dendrite location"@en ; rdfs:subPropertyOf obo:RO_0002131 . obo:RO_0002371 obo:IAO_0000115 "a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000589 "attached to (anatomical structure to anatomical structure)" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty, owl:SymmetricProperty ; rdfs:label "attached to"@en ; rdfs:subPropertyOf obo:RO_0002170, obo:RO_0002177 . obo:RO_0002372 obo:IAO_0000115 "m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to."@en ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "Wikipedia:Insertion_(anatomy)"@en ; a owl:ObjectProperty ; rdfs:domain obo:CARO_0000003 ; rdfs:label "has muscle origin"@en ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002371, obo:RO_0002567 . obo:RO_0002373 obo:IAO_0000115 "m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone."@en ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "Wikipedia:Insertion_(anatomy)"@en ; a owl:ObjectProperty ; rdfs:domain obo:CARO_0000003 ; rdfs:label "has muscle insertion"@en ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002371, obo:RO_0002567 . obo:RO_0002374 obo:IAO_0000112 false ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x has_fused_element y iff: there exists some z : x has_part z, z homologous_to y, and y is a distinct element, the boundary between x and z is largely fiat"@en ; obo:IAO_0000117 "Chris Mungall", "Chris Mungall"@en ; obo:IAO_0000119 ; oboInOwl:hasBroadSynonym "has fused element" ; a owl:ObjectProperty ; rdfs:comment "A has_fused_element B does not imply that A has_part some B: rather than A has_part some B', where B' that has some evolutionary relationship to B."@en ; rdfs:label "derived from ancestral fusion of"@en ; rdfs:subPropertyOf obo:RO_0002156 . obo:RO_0002375 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "A relationship that holds between two material entities in a system of connected structures, where the branching relationship holds based on properties of the connecting network." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving branching relationships", "This relation can be used for geographic features (e.g. rivers) as well as anatomical structures (plant branches and roots, leaf veins, animal veins, arteries, nerves)" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "in branching relationship with"@en ; rdfs:range obo:BFO_0000040 ; rdfs:seeAlso , "https://github.com/obophenotype/uberon/issues/170"^^xsd:anyURI ; rdfs:subPropertyOf obo:BFO_0000050, obo:RO_0002323 . obo:RO_0002376 obo:IAO_0000112 "Deschutes River tributary_of Columbia River", "inferior epigastric vein tributary_of external iliac vein" ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x tributary_of y if and only if x a channel for the flow of a substance into y, where y is larger than x. If x and y are hydrographic features, then y is the main stem of a river, or a lake or bay, but not the sea or ocean. If x and y are anatomical, then y is a vein." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "drains into", "drains to", "tributary channel of" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Tributary", "http://www.medindia.net/glossary/venous_tributary.htm" ; obo:IAO_0000232 "This relation can be used for geographic features (e.g. rivers) as well as anatomical structures (veins, arteries)"^^xsd:anyURI ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "tributary of"@en ; rdfs:seeAlso , "http://en.wikipedia.org/wiki/Tributary"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002375 . obo:RO_0002377 obo:IAO_0000112 "Deschutes River distributary_of Little Lava Lake" ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x distributary_of y if and only if x is capable of channeling the flow of a substance to y, where y channels less of the substance than x" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "branch of", "distributary channel of" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Distributary" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:comment "This is both a mereotopological relationship and a relationship defined in connection to processes. It concerns both the connecting structure, and how this structure is disposed to causally affect flow processes" ; rdfs:label "distributary of"@en ; rdfs:subPropertyOf obo:RO_0002375 . obo:RO_0002378 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x anabranch_of y if x is a distributary of y (i.e. it channels a from a larger flow from y) and x ultimately channels the flow back into y." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "anastomoses with" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "anabranch of"@en ; rdfs:subPropertyOf obo:RO_0002377, [ owl:inverseOf obo:RO_0002376 ] ; owl:propertyDisjointWith obo:RO_0002382, obo:RO_0002383 . obo:RO_0002379 obo:IAO_0000112 "A lump of clay and a statue" ; obo:IAO_0000115 "x spatially_coextensive_with y if and inly if x and y have the same location" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "This relation is added for formal completeness. It is unlikely to be used in many practical scenarios" ; a owl:ObjectProperty ; rdfs:label "spatially coextensive with"@en ; rdfs:subPropertyOf obo:RO_0002131 ; owl:propertyChainAxiom (obo:RO_0001025 [ owl:inverseOf obo:RO_0001025 ] ) . obo:RO_0002380 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x is a branching part of y if and only if x is part of y and x is connected directly or indirectly to the main stem of y" ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "branching part of"@en ; rdfs:range [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000402 ] ; rdfs:seeAlso "FMA:85994" ; rdfs:subPropertyOf obo:BFO_0000050, obo:RO_0002375 ; owl:inverseOf obo:RO_0002569 ; owl:propertyChainAxiom (obo:RO_0002377 obo:RO_0002381 ) . obo:RO_0002381 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x main_stem_of y if y is a branching structure and x is a channel that traces a linear path through y, such that x has higher capacity than any other such path." ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "main stem of"@en ; rdfs:subPropertyOf obo:RO_0002375 . obo:RO_0002382 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x proper_distributary_of y iff x distributary_of y and x does not flow back into y" ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "proper distributary of"@en ; rdfs:subPropertyOf obo:RO_0002377 . obo:RO_0002383 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x proper_tributary_of y iff x tributary_of y and x does not originate from y" ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "proper tributary of"@en ; rdfs:subPropertyOf obo:RO_0002376 . obo:RO_0002384 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction)."@en ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:domain obo:CARO_0000000 ; rdfs:label "has developmental potential involving"@en ; rdfs:range obo:CARO_0000000 ; rdfs:subPropertyOf obo:RO_0002324 . obo:RO_0002385 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y"@en ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "has potential to developmentally contribute to"@en ; rdfs:subPropertyOf obo:RO_0002384 . obo:RO_0002386 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y"@en ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "has potential to developmentally induce"@en ; rdfs:subPropertyOf obo:RO_0002384 . obo:RO_0002387 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x has the potential to develop into y iff x develops into y or if x is capable of developing into y"@en ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "has potential to develop into"@en ; rdfs:subPropertyOf obo:RO_0002384 . obo:RO_0002388 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y"@en ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "has potential to directly develop into"@en ; rdfs:subPropertyOf obo:RO_0002387 . obo:RO_0002400 obo:IAO_0000112 "'protein catabolic process' SubClassOf has_direct_input some protein" ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "p has direct input c iff c is a participant in p, c is present at the start of p, and the state of c is modified during p." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "directly consumes" ; obo:IAO_0000232 "This is likely to be obsoleted. A candidate replacement would be a new relation 'has bound input' or 'has substrate'" ; a owl:ObjectProperty ; rdfs:label "has direct input"@en ; rdfs:subPropertyOf obo:RO_0002233 ; owl:propertyChainAxiom (obo:RO_0002224 obo:RO_0002400 ) . obo:RO_0002401 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:comment """Likely to be obsoleted. See: https://docs.google.com/document/d/1QMhs9J-P_q3o_rDh-IX4ZEnz0PnXrzLRVkI3vvz8NEQ/edit""" ; rdfs:label "obsolete has indirect input"^^xsd:string ; owl:deprecated true . obo:RO_0002402 obo:IAO_0000112 "translation SubClassOf has_direct_output some protein" ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "p has direct input c iff c is a participanti n p, c is present at the end of p, and c is not present at the beginning of c. " ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "directly produces" ; a owl:ObjectProperty ; rdfs:label "obsolete has direct output"^^xsd:string ; owl:deprecated true . obo:RO_0002403 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:comment """Likely to be obsoleted. See: https://docs.google.com/document/d/1QMhs9J-P_q3o_rDh-IX4ZEnz0PnXrzLRVkI3vvz8NEQ/edit""" ; rdfs:label "obsolete has indirect output"^^xsd:string ; owl:deprecated true ; owl:propertyChainAxiom (obo:RO_0002411 obo:RO_0002402 ) . obo:RO_0002404 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "inverse of upstream of" ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "causally downstream of"@en ; rdfs:subPropertyOf obo:BFO_0000062, obo:RO_0002427 ; owl:inverseOf obo:RO_0002411 . obo:RO_0002405 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "immediately causally downstream of"@en ; rdfs:subPropertyOf obo:RO_0002087, obo:RO_0002404 ; owl:inverseOf obo:RO_0002412 . obo:RO_0002406 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "p directly activates q if and only if p is immediately upstream of q and p is the realization of a function to increase the rate or activity of q" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "directly positively regulates" ; obo:IAO_0000119 ; obo:IAO_0000589 "directly activates (process to process)" ; a owl:ObjectProperty ; rdfs:label "directly activates"@en ; rdfs:subPropertyOf obo:RO_0002629 . obo:RO_0002407 obo:IAO_0000115 "p indirectly activates q if and only if p is upstream of q and there is a chain of directly activates relationships connecting p and q, where the chain is of length greater than one." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "indirectly positively regulates" ; obo:RO_0002579 obo:RO_0002213 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "indirectly activates"@en ; rdfs:subPropertyOf obo:RO_0002213 ; owl:propertyChainAxiom (obo:RO_0002406 obo:RO_0002406 ), (obo:RO_0002406 obo:RO_0002407 ), (obo:RO_0002407 obo:RO_0002406 ), (obo:RO_0002409 obo:RO_0002409 ) . obo:RO_0002408 obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "directly negatively regulates" ; obo:IAO_0000119 ; obo:IAO_0000589 "directly inhibits (process to process)" ; a owl:ObjectProperty ; rdfs:label "directly inhibits"@en ; rdfs:subPropertyOf obo:RO_0002630 . obo:RO_0002409 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "indirectly negatively regulates" ; obo:RO_0002579 obo:RO_0002212 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "indirectly inhibits"@en ; rdfs:subPropertyOf obo:RO_0002212 ; owl:propertyChainAxiom (obo:RO_0002408 obo:RO_0002408 ), (obo:RO_0002408 obo:RO_0002409 ), (obo:RO_0002409 obo:RO_0002408 ) . obo:RO_0002410 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "This relation groups causal relations between material entities and causal relations between processes" ; obo:IAO_0000116 """This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents. To define causal relations in an activity-flow type network, we make use of 3 primitives: * Temporal: how do the intervals of the two occurrents relate? * Is the causal relation regulatory? * Is the influence positive or negative The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified. For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule. For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral. Each of these 3 primitives can be composed to yield a cross-product of different relation types.""" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." ; a owl:ObjectProperty ; rdfs:label "causally related to"@en . obo:RO_0002411 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain" ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_gocam ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "causally upstream of"@en ; rdfs:subPropertyOf obo:BFO_0000063, obo:RO_0002418 . obo:RO_0002412 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q." ; obo:IAO_0000117 "Chris Mungall" ; obo:RO_0002575 obo:RO_0002411 ; a owl:ObjectProperty ; rdfs:label "immediately causally upstream of"@en ; rdfs:subPropertyOf obo:RO_0002090, obo:RO_0002411 . obo:RO_0002413 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "p1 directly provides input for p2 iff there exists some c such that p1 has_output c and p2 has_input c" ; obo:IAO_0000116 "This is currently called 'directly provides input for' to be consistent with our terminology where we use 'direct' whenever two occurrents succeed one another directly. We may relabel this simply 'provides input for', as directness is implicit" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 ; obo:IAO_0000589 "directly provides input for (process to process)" ; a owl:ObjectProperty ; rdfs:label "directly provides input for"@en ; rdfs:subPropertyOf obo:RO_0002412, obo:RO_0002414 ; owl:propertyChainAxiom (obo:RO_0002402 obo:RO_0002400 ) . obo:RO_0002414 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "transitive form of directly_provides_input_for" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "This is a grouping relation that should probably not be used in annotation. Consider instead the child relation 'directly provides input for' (which may later be relabeled simply to 'provides input for')" ; obo:IAO_0000589 "transitively provides input for (process to process)" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "transitively provides input for"@en ; rdfs:range obo:BFO_0000015 ; rdfs:subPropertyOf obo:RO_0002411 . obo:RO_0002416 obo:IAO_0000115 "An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL." ; a owl:AnnotationProperty ; rdfs:label "logical macro assertion"@en ; rdfs:seeAlso "http://purl.obolibrary.org/obo/ro/docs/shortcut-relations/"^^xsd:anyURI . obo:RO_0002418 obo:IAO_0000115 "p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q." ; obo:IAO_0000116 "We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "influences (processual)" ; oboInOwl:hasRelatedSynonym "affects" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "causally upstream of or within" ; rdfs:subPropertyOf obo:RO_0002501 ; owl:inverseOf obo:RO_0002427 . obo:RO_0002419 obo:IAO_0000115 "An assertion that holds between an OWL Annotation Property P and a non-negative integer N, with the interpretation: for any P(i j) it must be the case that | { k : P(i k) } | = N." ; a owl:AnnotationProperty ; rdfs:label "annotation property cardinality"@en ; rdfs:range xsd:nonNegativeInteger ; rdfs:subPropertyOf obo:RO_0002423 . obo:RO_0002420 obo:IAO_0000115 "A logical macro assertion whose domain is an IRI for a class" ; obo:IAO_0000116 "The domain for this class can be considered to be owl:Class, but we cannot assert this in OWL2-DL" ; a owl:AnnotationProperty ; rdfs:label "logical macro assertion on a class"@en ; rdfs:subPropertyOf obo:RO_0002416 . obo:RO_0002421 obo:IAO_0000115 "A logical macro assertion whose domain is an IRI for a property" ; a owl:AnnotationProperty ; rdfs:label "logical macro assertion on a property"@en ; rdfs:subPropertyOf obo:RO_0002416 . obo:RO_0002422 obo:IAO_0000115 "Used to annotate object properties to describe a logical meta-property or characteristic of the object property." ; a owl:AnnotationProperty ; rdfs:label "logical macro assertion on an object property"@en ; rdfs:subPropertyOf obo:RO_0002421 . obo:RO_0002423 a owl:AnnotationProperty ; rdfs:label "logical macro assertion on an annotation property"@en ; rdfs:subPropertyOf obo:RO_0002421 . obo:RO_0002424 obo:IAO_0000116 false ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:comment "This is an exploratory relation" ; rdfs:label "differs in"@en ; rdfs:seeAlso "https://code.google.com/p/phenotype-ontologies/w/edit/PhenotypeModelCompetencyQuestions"^^xsd:anyURI . obo:RO_0002425 obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "differs in attribute of"@en ; rdfs:range [ a owl:Class ; owl:unionOf (obo:BFO_0000004 obo:BFO_0000015 ) ] ; rdfs:subPropertyOf obo:RO_0002424 . obo:RO_0002426 obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "differs in attribute"@en ; rdfs:range obo:BFO_0000020 ; rdfs:subPropertyOf obo:RO_0002424 . obo:RO_0002427 obo:IAO_0000115 "inverse of causally upstream of or within" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "causally downstream of or within" ; rdfs:subPropertyOf obo:RO_0002501 . obo:RO_0002428 obo:IAO_0000115 "c involved in regulation of p if c is involved in some p' and p' regulates some p" ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "involved in regulation of" ; rdfs:subPropertyOf obo:RO_0002263, obo:RO_0002431 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002211 ), (obo:RO_0002331 obo:RO_0002211 ) . obo:RO_0002429 obo:IAO_0000115 "c involved in regulation of p if c is involved in some p' and p' positively regulates some p" ; obo:IAO_0000117 "Chris Mungall" ; obo:RO_0004049 obo:RO_0002428 ; a owl:ObjectProperty ; rdfs:label "involved in positive regulation of" ; rdfs:subPropertyOf obo:RO_0002428 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002213 ), (obo:RO_0002331 obo:RO_0002213 ) . obo:RO_0002430 obo:IAO_0000115 "c involved in regulation of p if c is involved in some p' and p' negatively regulates some p" ; obo:IAO_0000117 "Chris Mungall" ; obo:RO_0004050 obo:RO_0002428 ; a owl:ObjectProperty ; rdfs:label "involved in negative regulation of" ; rdfs:subPropertyOf obo:RO_0002428 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002212 ), (obo:RO_0002331 obo:RO_0002212 ) . obo:RO_0002431 obo:IAO_0000115 "c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p" ; obo:IAO_0000116 "OWL does not allow defining object properties via a Union" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "involved in or reguates" ; a owl:ObjectProperty ; rdfs:label "involved in or involved in regulation of" ; rdfs:subPropertyOf obo:RO_0002264, obo:RO_0002328, obo:RO_0002500 . obo:RO_0002432 obo:IAO_0000112 "A protein that enables activity in a cytosol." ; obo:IAO_0000115 "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "executes activity in" ; oboInOwl:hasExactSynonym "enables activity in" ; a owl:ObjectProperty ; rdfs:comment "" ; rdfs:label "is active in" ; rdfs:subPropertyOf obo:RO_0002131, obo:RO_0002328 ; owl:propertyChainAxiom (obo:RO_0002327 obo:BFO_0000066 ) . obo:RO_0002433 obo:IAO_0000115 "p contributes to morphology of w if and only if a change in the morphology of p entails a change in the morphology of w. Examples: every skull contributes to morphology of the head which it is a part of. Counter-example: nuclei do not generally contribute to the morphology of the cell they are part of, as they are buffered by cytoplasm." ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "contributes to morphology of" ; rdfs:subPropertyOf obo:RO_0002131 . obo:RO_0002434 obo:IAO_0000115 "A relationship that holds between two entities in which the processes executed by the two entities are causally connected." ; obo:IAO_0000116 "Considering relabeling as 'pairwise interacts with'"^^xsd:anyURI, "This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules." ; oboInOwl:hasExactSynonym "in pairwise interaction with" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty, owl:SymmetricProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "interacts with" ; rdfs:range obo:BFO_0000040 ; rdfs:seeAlso "http://purl.obolibrary.org/obo/ro/docs/interaction-relations/"^^xsd:anyURI ; skos:closeMatch "http://purl.obolibrary.org/obo/MI_0914"^^xsd:anyURI . obo:RO_0002435 obo:IAO_0000116 "An interaction that holds between two genetic entities (genes, alleles) through some genetic interaction (e.g. epistasis)" ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty, owl:SymmetricProperty ; rdfs:label "genetically interacts with" ; rdfs:seeAlso obo:ECO_0000316 ; rdfs:subPropertyOf obo:RO_0002434 ; skos:closeMatch "http://purl.obolibrary.org/obo/MI_0208"^^xsd:anyURI . obo:RO_0002436 obo:IAO_0000115 "An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "binds", "molecularly binds with" ; a owl:ObjectProperty, owl:SymmetricProperty ; rdfs:label "molecularly interacts with" ; rdfs:seeAlso obo:ECO_0000353 ; rdfs:subPropertyOf obo:RO_0002434 ; skos:closeMatch "http://purl.obolibrary.org/obo/MI_0915"^^xsd:anyURI . obo:RO_0002437 obo:IAO_0000115 "An interaction relationship in which at least one of the partners is an organism and the other is either an organism or an abiotic entity with which the organism interacts." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "interacts with on organism level" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty, owl:SymmetricProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "biotically interacts with" ; rdfs:range obo:BFO_0000040 ; rdfs:seeAlso , "http://eol.org/schema/terms/interactsWith" ; rdfs:subPropertyOf obo:RO_0002321, obo:RO_0002434 . obo:RO_0002438 obo:IAO_0000115 "An interaction relationship in which the partners are related via a feeding relationship." ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "trophically interacts with" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002574 . obo:RO_0002439 obo:IAO_0000112 "A wasp killing a Monarch larva in order to feed to offspring [http://www.inaturalist.org/observations/2942824]", "Baleen whale preys on krill" ; obo:IAO_0000115 "An interaction relationship involving a predation process, where the subject kills the target in order to eat it or to feed to siblings, offspring or group members" ; obo:IAO_0000117 "Chris Mungall", "Jorrit Poelen", "Katja Shulz" ; obo:IAO_0000118 "is subject of predation interaction with", "preys upon" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "preys on" ; rdfs:seeAlso "http://eol.org/schema/terms/preysUpon", "http://www.inaturalist.org/observations/2942824" ; rdfs:subPropertyOf obo:RO_0002438 ; owl:inverseOf obo:RO_0002458 . obo:RO_0002440 obo:IAO_0000115 "A biotic interaction in which the two organisms live together in more or less intimate association." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/19278549"^^xsd:anyURI ; obo:IAO_0000232 "We follow GO and PAMGO in using 'symbiosis' as the broad term encompassing mutualism through parasitism" ; obo:RO_0002561 obo:GO_0044403 ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty, owl:SymmetricProperty ; rdfs:label "symbiotically interacts with" ; rdfs:subPropertyOf obo:RO_0002574 ; owl:propertyChainAxiom (obo:RO_0002461 obo:RO_0002465 [ owl:inverseOf obo:RO_0002461 ] ) . obo:RO_0002441 obo:IAO_0000115 "An interaction relationship between two organisms living together in more or less intimate association in a relationship in which one benefits and the other is unaffected (GO)." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/19278549"^^xsd:anyURI ; obo:RO_0002561 obo:GO_0085031 ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "commensually interacts with" ; rdfs:subPropertyOf obo:RO_0002440 ; owl:propertyChainAxiom (obo:RO_0002461 obo:RO_0002466 [ owl:inverseOf obo:RO_0002461 ] ) . obo:RO_0002442 obo:IAO_0000115 "An interaction relationship between two organisms living together in more or less intimate association in a relationship in which both organisms benefit from each other (GO)." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/19278549"^^xsd:anyURI ; obo:RO_0002561 obo:GO_0085030 ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "mutualistically interacts with" ; rdfs:subPropertyOf obo:RO_0002440 ; owl:propertyChainAxiom (obo:RO_0002461 obo:RO_0002467 [ owl:inverseOf obo:RO_0002461 ] ) . obo:RO_0002443 obo:IAO_0000115 "An interaction relationship between two organisms living together in more or less intimate association in a relationship in which association is disadvantageous or destructive to one of the organisms (GO)." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/19278549"^^xsd:anyURI ; obo:IAO_0000232 "This relation groups a pair of inverse relations, parasite of and parasitized by" ; obo:RO_0002561 obo:GO_0072519 ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "interacts with via parasite-host interaction" ; rdfs:subPropertyOf obo:RO_0002440 ; owl:propertyChainAxiom (obo:RO_0002461 obo:RO_0002468 [ owl:inverseOf obo:RO_0002461 ] ) . obo:RO_0002444 obo:IAO_0000112 "Pediculus humanus capitis parasite of human" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "parasitizes" ; obo:RO_0002560 obo:GO_0072519 ; oboInOwl:hasExactSynonym "direct parasite of" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "parasite of" ; rdfs:seeAlso "http://eol.org/schema/terms/parasitizes" ; rdfs:subPropertyOf obo:RO_0002443, obo:RO_0002454 ; owl:inverseOf obo:RO_0002445 ; owl:propertyChainAxiom (obo:RO_0002462 obo:RO_0002468 [ owl:inverseOf obo:RO_0002463 ] ) . obo:RO_0002445 obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "has parasite", "parasitised by" ; oboInOwl:hasExactSynonym "directly parasitized by" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "parasitized by" ; rdfs:seeAlso "http://eol.org/schema/terms/hasParasite" ; rdfs:subPropertyOf obo:RO_0002443, obo:RO_0002453 . obo:RO_0002446 obo:IAO_0000112 "Porifiera attaches to substrate" ; obo:IAO_0000115 "A biotic interaction relationship in which one partner is an organism and the other partner is inorganic. For example, the relationship between a sponge and the substrate to which is it anchored." ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:hasRelatedSynonym "semibiotically interacts with" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "participates in a abiotic-biotic interaction with" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002437 . obo:RO_0002447 obo:IAO_0000116 "Axiomatization to GO to be added later" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y." ; a owl:ObjectProperty ; rdfs:label "phosphorylates" ; rdfs:subPropertyOf obo:RO_0002436 ; owl:propertyChainAxiom (obo:RO_0002215 obo:RO_0002481 obo:RO_0002400 ) . obo:RO_0002448 obo:IAO_0000115 """The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B. A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B.""" ; obo:IAO_0000117 "Chris Mungall", "Vasundra Touré" ; oboInOwl:hasExactSynonym "molecularly controls" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "directly regulates activity of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0002436, obo:RO_0011002 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002211 obo:RO_0002333 ) . obo:RO_0002449 obo:IAO_0000115 """The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B.""" ; obo:IAO_0000117 "Chris Mungall", "Vasundra Touré" ; obo:IAO_0000118 "directly inhibits" ; oboInOwl:hasExactSynonym "molecularly decreases activity of" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "directly negatively regulates activity of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0002448 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002630 obo:RO_0002333 ) . obo:RO_0002450 obo:IAO_0000115 """The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B.""" ; obo:IAO_0000117 "Chris Mungall", "Vasundra Touré" ; obo:IAO_0000118 "directly activates" ; oboInOwl:hasExactSynonym "molecularly increases activity of" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "directly positively regulates activity of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0002448 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002629 obo:RO_0002333 ) . obo:RO_0002451 obo:IAO_0000112 "all dengue disease transmitted by some mosquito" ; obo:IAO_0000115 "A relationship that holds between a disease and organism" ; obo:IAO_0000116 "Add domain and range constraints" ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "transmitted by" ; rdfs:subPropertyOf obo:RO_0002321 . obo:RO_0002452 obo:IAO_0000115 "A relation that holds between a disease or an organism and a phenotype" ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:domain obo:OGMS_0000031 ; rdfs:label "has symptom" ; rdfs:subPropertyOf obo:RO_0002200 . obo:RO_0002453 obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "The term host is usually used for the larger (macro) of the two members of a symbiosis (GO)" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "host of" ; rdfs:subPropertyOf obo:RO_0002440 . obo:RO_0002454 obo:IAO_0000115 "X 'has host' y if and only if: x is an organism, y is an organism, and x can live on the surface of or within the body of y" ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "has host" ; rdfs:seeAlso "http://eol.org/schema/terms/hasHost" ; rdfs:subPropertyOf obo:RO_0002440 . obo:RO_0002455 obo:IAO_0000112 "Bees pollinate Flowers" ; obo:IAO_0000116 "This relation is intended to be used for biotic pollination - e.g. a bee pollinating a flowering plant. Some kinds of pollination may be semibiotic - e.g. wind can have the role of pollinator. We would use a separate relation for this." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "is subject of pollination interaction with" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "pollinates" ; rdfs:seeAlso "http://eol.org/schema/terms/pollinates" ; rdfs:subPropertyOf obo:RO_0002442 ; owl:inverseOf obo:RO_0002456 . obo:RO_0002456 obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "has polinator", "is target of pollination interaction with" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "pollinated by" ; rdfs:seeAlso "http://eol.org/schema/terms/hasPollinator" ; rdfs:subPropertyOf obo:RO_0002442 . obo:RO_0002457 obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "Intended to be used when the target of the relation is not itself consumed, and does not have integral parts consumed, but provided nutrients in some other fashion." ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "acquires nutrients from" ; rdfs:subPropertyOf obo:RO_0002438 ; owl:inverseOf obo:RO_0002469 . obo:RO_0002458 obo:IAO_0000115 "inverse of preys on" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "has predator", "is target of predation interaction with" ; oboInOwl:inSubset obo:RO_0002259, subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "preyed upon by" ; rdfs:seeAlso "http://eol.org/schema/terms/HasPredator", "http://polytraits.lifewatchgreece.eu/terms/PRED" ; rdfs:subPropertyOf obo:RO_0002438 . obo:RO_0002459 obo:IAO_0000112 "Anopheles is a vector for Plasmodium" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "a is a vector for b if a carries and transmits an infectious pathogen b into another living organism" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "is vector for" ; rdfs:subPropertyOf obo:RO_0002574 ; owl:inverseOf obo:RO_0002460 . obo:RO_0002460 obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "has vector" ; rdfs:subPropertyOf obo:RO_0002574 . obo:RO_0002461 obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "Experimental: relation used for defining interaction relations. An interaction relation holds when there is an interaction event with two partners. In a directional interaction, one partner is deemed the subject, the other the target" ; a owl:ObjectProperty ; rdfs:label "partner in" ; rdfs:subPropertyOf obo:RO_0000056 . obo:RO_0002462 obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "Experimental: relation used for defining interaction relations; the meaning of s 'subject participant in' p is determined by the type of p, where p must be a directional interaction process. For example, in a predator-prey interaction process the subject is the predator. We can imagine a reciprocal prey-predatory process with subject and object reversed." ; a owl:ObjectProperty ; rdfs:label "subject participant in" ; rdfs:subPropertyOf obo:RO_0002461 . obo:RO_0002463 obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "Experimental: relation used for defining interaction relations; the meaning of s 'target participant in' p is determined by the type of p, where p must be a directional interaction process. For example, in a predator-prey interaction process the target is the prey. We can imagine a reciprocal prey-predatory process with subject and object reversed." ; a owl:ObjectProperty ; rdfs:label "target participant in" ; rdfs:subPropertyOf obo:RO_0002461 . obo:RO_0002464 obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "This property or its subproperties is not to be used directly. These properties exist as helper properties that are used to support OWL reasoning." ; a owl:ObjectProperty ; rdfs:label "helper property (not for use in curation)" . obo:RO_0002465 obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "is symbiosis" ; rdfs:subPropertyOf obo:RO_0002563 . obo:RO_0002466 obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "is commensalism" ; rdfs:subPropertyOf obo:RO_0002465 . obo:RO_0002467 obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "is mutualism" ; rdfs:subPropertyOf obo:RO_0002465 . obo:RO_0002468 obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "is parasitism" ; rdfs:subPropertyOf obo:RO_0002465 . obo:RO_0002469 obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "provides nutrients for" ; rdfs:subPropertyOf obo:RO_0002438 . obo:RO_0002470 obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "is subject of eating interaction with" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "eats" ; rdfs:subPropertyOf obo:RO_0002438 . obo:RO_0002471 obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "eaten by", "is target of eating interaction with" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "is eaten by" ; rdfs:subPropertyOf obo:RO_0002438 . obo:RO_0002472 obo:IAO_0000115 """A relationship between a piece of evidence a and some entity b, where b is an information content entity, material entity or process, and the a supports either the existence of b, or the truth value of b.""" ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "is evidence for" ; rdfs:subPropertyOf obo:RO_0002616 ; owl:inverseOf obo:RO_0002558 . obo:RO_0002473 obo:IAO_0000112 "'otolith organ' SubClassOf 'composed primarily of' some 'calcium carbonate'" ; obo:IAO_0000115 "x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "composed primarily of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:BFO_0000051 . obo:RO_0002474 obo:IAO_0000115 "An assertion that holds between an OWL Object Property and a dispositional interpretation that elucidates how OWL Class Axioms or OWL Individuals that use this property are to be interpreted in a dispositional context. For example, A binds B may be interpreted as A have a mutual disposition that is realized by binding to the other one." ; a owl:AnnotationProperty ; rdfs:label "dispositional interpretation" ; rdfs:subPropertyOf obo:RO_0002422 . obo:RO_0002475 obo:IAO_0000112 "'pectoral appendage skeleton' has no connections with 'pelvic appendage skeleton'" ; obo:IAO_0000115 "A is has_no_connections_with B if there are no parts of A or B that have a connection with the other." ; obo:IAO_0000118 "shares no connection with" ; obo:IAO_0000425 "Class: EquivalentTo: (BFO_0000050 some ?X) and (RO_0002170 some (BFO_0000050 some ?Y))" ; a owl:AnnotationProperty ; rdfs:label "has no connections with" ; rdfs:subPropertyOf obo:RO_0002420 . obo:RO_0002476 obo:IAO_0000112 "ABal nucleus child nucleus of ABa nucleus (in C elegans)" ; obo:IAO_0000115 "c is a child nucleus of d if and only if c and d are both nuclei and parts of cells c' and d', where c' is derived from d' by mitosis and the genetic material in c is a copy of the generic material in d" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "This relation is primarily used in the worm anatomy ontology for representing lineage at the level of nuclei. However, it is applicable to any organismal cell lineage." ; a owl:ObjectProperty ; rdfs:domain obo:GO_0005634 ; rdfs:label "child nucleus of" ; rdfs:range obo:GO_0005634 ; rdfs:subPropertyOf obo:RO_0002258 . obo:RO_0002477 obo:IAO_0000115 "A child nucleus relationship in which the cells are part of a hermaphroditic organism" ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "child nucleus of in hermaphrodite" ; rdfs:subPropertyOf obo:RO_0002476 . obo:RO_0002478 obo:IAO_0000115 "A child nucleus relationship in which the cells are part of a male organism" ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "child nucleus of in male" ; rdfs:subPropertyOf obo:RO_0002476 . obo:RO_0002479 obo:IAO_0000115 "p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c." ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000003 ; rdfs:label "has part that occurs in" ; rdfs:range obo:BFO_0000004 ; owl:propertyChainAxiom (obo:BFO_0000051 obo:BFO_0000066 ) . obo:RO_0002480 obo:IAO_0000115 "An interaction relation between x and y in which x catalyzes a reaction in which one or more ubiquitin groups are added to y" ; obo:IAO_0000116 "Axiomatization to GO to be added later" ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "ubiquitinates" ; rdfs:subPropertyOf obo:RO_0002436 ; owl:propertyChainAxiom (obo:RO_0002215 obo:RO_0002482 obo:RO_0002400 ) . obo:RO_0002481 obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "is kinase activity" ; rdfs:subPropertyOf obo:RO_0002564 . obo:RO_0002482 obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "is ubiquitination" ; rdfs:subPropertyOf obo:RO_0002564 . obo:RO_0002483 a owl:AnnotationProperty ; rdfs:label "inherited annotation property" . obo:RO_0002484 obo:IAO_0000115 "Connects an ontology entity (class, property, etc) to a URL from which curator guidance can be obtained. This assertion is inherited in the same manner as functional annotations (e.g. for GO, over SubClassOf and part_of)" ; a owl:AnnotationProperty ; rdfs:label "curator guidance link" ; rdfs:subPropertyOf obo:RO_0002483 . obo:RO_0002485 obo:IAO_0000116 "See notes for inverse relation" ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "receives input from" ; rdfs:subPropertyOf obo:RO_0002170 ; owl:inverseOf obo:RO_0002486 . obo:RO_0002486 obo:IAO_0000116 "This is an exploratory relation. The label is taken from the FMA. It needs aligned with the neuron-specific relations such as has postsynaptic terminal in." ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "sends output to" ; rdfs:subPropertyOf obo:RO_0002170 . obo:RO_0002487 obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, typically connecting an anatomical entity to a biological process or developmental stage." ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "relation between physical entity and a process or stage" ; rdfs:range obo:BFO_0000003 . obo:RO_0002488 obo:IAO_0000115 "x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y)." ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "existence starts during" ; rdfs:subPropertyOf obo:RO_0002490, obo:RO_0002496 ; owl:propertyChainAxiom (obo:RO_0002488 obo:BFO_0000050 ), (obo:RO_0002583 obo:BFO_0000050 ) . obo:RO_0002489 obo:IAO_0000115 "x starts ends with y if and only if the time point at which x starts is equivalent to the time point at which y starts. Formally: x existence starts with y iff α(x) = α(y)." ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "existence starts with" ; rdfs:subPropertyOf obo:RO_0002488 . obo:RO_0002490 obo:IAO_0000115 "x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y))" ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:comment "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ; rdfs:label "existence overlaps" ; rdfs:subPropertyOf obo:RO_0002487 . obo:RO_0002491 obo:IAO_0000115 "x exists during y if and only if: 1) the time point at which x begins to exist is after or equal to the time point at which y begins and 2) the time point at which x ceases to exist is before or equal to the point at which y ends. Formally: x existence starts and ends during y iff α(x) >= α(y) & α(x) <= ω(y) & ω(x) <= ω(y) & ω(x) >= α(y)"^^xsd:string ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:hasExactSynonym "exists during"^^xsd:string ; a owl:ObjectProperty ; rdfs:comment "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ; rdfs:label "existence starts and ends during" ; rdfs:subPropertyOf obo:RO_0002488, obo:RO_0002492 . obo:RO_0002492 obo:IAO_0000115 "x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y)." ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:comment "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ; rdfs:label "existence ends during" ; rdfs:subPropertyOf obo:RO_0002490, obo:RO_0002497 ; owl:propertyChainAxiom (obo:RO_0002492 obo:BFO_0000050 ), (obo:RO_0002593 obo:BFO_0000050 ) . obo:RO_0002493 obo:IAO_0000115 "x existence ends with y if and only if the time point at which x ends is equivalent to the time point at which y ends. Formally: x existence ends with y iff ω(x) = ω(y)." ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:comment "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ; rdfs:label "existence ends with" ; rdfs:subPropertyOf obo:RO_0002492 . obo:RO_0002494 obo:IAO_0000115 "x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships" ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "transformation of" ; rdfs:subPropertyOf obo:RO_0002202 . obo:RO_0002495 obo:IAO_0000115 "x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t" ; obo:IAO_0000117 "Chris Mungall" ; obo:RO_0002575 obo:RO_0002494 ; a owl:ObjectProperty ; rdfs:label "immediate transformation of" ; rdfs:subPropertyOf obo:RO_0002207, obo:RO_0002494 . obo:RO_0002496 obo:IAO_0000115 "x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y)." ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:comment "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ; rdfs:label "existence starts during or after" ; rdfs:subPropertyOf obo:RO_0002487 ; owl:propertyChainAxiom (obo:BFO_0000050 obo:RO_0002496 ), (obo:RO_0002258 obo:RO_0002496 ), (obo:RO_0002496 obo:BFO_0000050 ), (obo:RO_0002496 obo:BFO_0000062 ), (obo:RO_0002496 obo:RO_0002082 ), (obo:RO_0002583 obo:BFO_0000062 [ owl:inverseOf obo:RO_0002583 ] ) . obo:RO_0002497 obo:IAO_0000115 "x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends." ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:comment "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ; rdfs:label "existence ends during or before" ; rdfs:subPropertyOf obo:RO_0002487 ; owl:propertyChainAxiom (obo:BFO_0000050 obo:RO_0002497 ), (obo:RO_0002286 obo:RO_0002497 ), (obo:RO_0002497 obo:BFO_0000050 ), (obo:RO_0002497 obo:BFO_0000063 ), (obo:RO_0002497 obo:RO_0002082 ), (obo:RO_0002593 obo:BFO_0000063 [ owl:inverseOf obo:RO_0002593 ] ) . obo:RO_0002500 obo:IAO_0000115 "A relationship between a material entity and a process where the material entity has some causal role that influences the process" ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "causal agent in process" ; rdfs:subPropertyOf obo:RO_0002595 ; owl:inverseOf obo:RO_0002608 . obo:RO_0002501 obo:IAO_0000115 "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 ; obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000003 ; rdfs:label "causal relation between processes" ; rdfs:range obo:BFO_0000003 ; rdfs:subPropertyOf obo:RO_0002410 . obo:RO_0002502 obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "depends on" ; rdfs:seeAlso obo:BFO_0000169 . obo:RO_0002503 obo:IAO_0000115 "q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2" ; obo:IAO_0000116 "This relation is provided in order to support the use of relational qualities such as 'concentration of'; for example, the concentration of C in V is a quality that inheres in V, but pertains to C." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "towards" ; rdfs:subPropertyOf obo:RO_0002502 . obo:RO_0002504 obo:IAO_0000112 "brain always_present_in_taxon 'Vertebrata'", "forelimb always_present_in_taxon Euarchontoglires" ; obo:IAO_0000115 "S always_present_in_taxon T if every fully formed member of taxon T has part some S, or is an instance of S" ; obo:IAO_0000116 "This is a very strong relation. Often we will not have enough evidence to know for sure that there are no species within a lineage that lack the structure - loss is common in evolution. However, there are some statements we can make with confidence - no vertebrate lineage could persist without a brain or a heart. All primates are limbed. " ; obo:IAO_0000118 "never lost in" ; a owl:AnnotationProperty ; rdfs:label "always present in taxon" ; rdfs:subPropertyOf obo:RO_0002175 . obo:RO_0002505 obo:IAO_0000112 "'lysine biosynthetic process via diaminopimelate' SubClassOf has_intermediate some diaminopimelate" ; obo:IAO_0000115 "p has intermediate c if and only if p has parts p1, p2 and p1 has output c, and p2 has input c" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "has intermediate product" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "has intermediate" ; rdfs:subPropertyOf obo:RO_0000057 . obo:RO_0002506 obo:IAO_0000116 "The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 ; obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000002 ; rdfs:label "causal relation between entities" ; rdfs:range obo:BFO_0000002 ; rdfs:subPropertyOf obo:RO_0002410 . obo:RO_0002507 obo:IAO_0000112 "A coral reef environment is determined by a particular coral reef" ; obo:IAO_0000115 "s determined by f if and only if s is a type of system, and f is a material entity that is part of s, such that f exerts a strong causal influence on the functioning of s, and the removal of f would cause the collapse of s." ; obo:IAO_0000116 "The label for this relation is probably too general for its restricted use, where the domain is a system. It may be relabeled in future" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 ; obo:IAO_0000589 "determined by (system to material entity)" ; terms:creator "Chris Mungall", "Pier Buttigieg" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain obo:RO_0002577 ; rdfs:label "determined by" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:BFO_0000050, obo:RO_0002509, obo:RO_0002559 ; owl:inverseOf obo:RO_0002508 . obo:RO_0002508 obo:IAO_0000115 "inverse of determined by" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000589 "determines (material entity to system)" ; oboInOwl:inSubset obo:RO_0002259, subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "determines" ; rdfs:subPropertyOf obo:RO_0002566 . obo:RO_0002509 obo:IAO_0000115 "s 'determined by part of' w if and only if there exists some f such that (1) s 'determined by' f and (2) f part_of w, or f=w." ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain obo:RO_0002577 ; rdfs:label "determined by part of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0002131, obo:RO_0002506 ; owl:propertyChainAxiom (obo:RO_0002507 obo:BFO_0000050 ) . obo:RO_0002510 obo:IAO_0000115 "x is transcribed from y if and only if x is synthesized from template y" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ; a owl:ObjectProperty ; rdfs:domain [ a owl:Class ; owl:unionOf (obo:BFO_0000031 obo:BFO_0000040 ) ] ; rdfs:label "transcribed from" ; rdfs:range [ a owl:Class ; owl:unionOf (obo:BFO_0000031 obo:BFO_0000040 ) ] ; rdfs:subPropertyOf obo:RO_0002330 ; owl:inverseOf obo:RO_0002511 . obo:RO_0002511 obo:IAO_0000115 "inverse of transcribed from" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "transcribed to" ; rdfs:subPropertyOf obo:RO_0002330 . obo:RO_0002512 obo:IAO_0000115 "x is the ribosomal translation of y if and only if a ribosome reads x through a series of triplet codon-amino acid adaptor activities (GO:0030533) and produces y" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ; a owl:ObjectProperty ; rdfs:domain [ a owl:Class ; owl:unionOf (obo:BFO_0000031 obo:BFO_0000040 ) ] ; rdfs:label "ribosomal translation of" ; rdfs:range [ a owl:Class ; owl:unionOf (obo:BFO_0000031 obo:BFO_0000040 ) ] ; rdfs:subPropertyOf obo:RO_0002330 ; owl:inverseOf obo:RO_0002513 . obo:RO_0002513 obo:IAO_0000115 "inverse of ribosomal translation of" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ; a owl:ObjectProperty ; rdfs:domain [ a owl:Class ; owl:unionOf (obo:BFO_0000031 obo:BFO_0000040 ) ] ; rdfs:label "ribosomally translates to" ; rdfs:range [ a owl:Class ; owl:unionOf (obo:BFO_0000031 obo:BFO_0000040 ) ] ; rdfs:subPropertyOf obo:RO_0002330 . obo:RO_0002514 obo:IAO_0000115 "A relation that holds between two entities that have the property of being sequences or having sequences. " ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ; obo:IAO_0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving cause and effect.", "The domain and range of this relation include entities such as: information-bearing macromolecules such as DNA, or regions of these molecules; abstract information entities encoded as a linear sequence including text, abstract DNA sequences; Sequence features, entities that have a sequence or sequences. Note that these entities are not necessarily contiguous - for example, the mereological sum of exons on a genome of a particular gene." ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:domain obo:RO_0002532 ; rdfs:label "sequentially related to" ; rdfs:range obo:RO_0002532 . obo:RO_0002515 obo:IAO_0000112 "Every UTR is adjacent to a CDS of the same transcript", "Two consecutive DNA residues are sequentially adjacent", "Two exons on a processed transcript that were previously connected by an intron are adjacent" ; obo:IAO_0000115 "x is sequentially adjacent to y iff x and y do not overlap and if there are no base units intervening between x and y" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:label "sequentially adjacent to" ; rdfs:subPropertyOf obo:RO_0002527 . obo:RO_0002516 obo:IAO_0000112 "Every CDS has as a start sequence the start codon for that transcript" ; obo:IAO_0000115 "x has start sequence y if the start of x is identical to the start of y, and x has y as a subsequence" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "started by" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ; cito:citesAsAuthority ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "has start sequence" ; rdfs:subPropertyOf obo:RO_0002524 ; owl:inverseOf obo:RO_0002517 . obo:RO_0002517 obo:IAO_0000115 "inverse of has start sequence" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "starts" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ; cito:citesAsAuthority ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "is start sequence of" ; rdfs:subPropertyOf obo:RO_0002525 . obo:RO_0002518 obo:IAO_0000112 "Every CDS has as an end sequence the stop codon for that transcript (note this follows from the SO definition of CDS, in which stop codons are included)" ; obo:IAO_0000115 "x has end sequence y if the end of x is identical to the end of y, and x has y as a subsequence" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "ended by" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ; cito:citesAsAuthority ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "has end sequence" ; rdfs:subPropertyOf obo:RO_0002524 ; owl:inverseOf obo:RO_0002519 . obo:RO_0002519 obo:IAO_0000115 "inverse of has end sequence" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "ends" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ; cito:citesAsAuthority ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "is end sequence of" ; rdfs:subPropertyOf obo:RO_0002525 . obo:RO_0002520 obo:IAO_0000115 "x is a consecutive sequence of y iff x has subsequence y, and all the parts of x are made of zero or more repetitions of y or sequences as the same type as y." ; obo:IAO_0000116 "In the SO paper, this was defined as an instance-type relation" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:label "is consecutive sequence of" ; rdfs:subPropertyOf obo:RO_0002524 . obo:RO_0002521 obo:IAO_0000112 "Human Shh and Mouse Shh are sequentially aligned, by cirtue of the fact that they derive from the same ancestral sequence." ; obo:IAO_0000115 "x is sequentially aligned with if a significant portion bases of x and y correspond in terms of their base type and their relative ordering" ; obo:IAO_0000117 "Chris Mungall" ; cito:citesAsAuthority ; a owl:ObjectProperty, owl:SymmetricProperty ; rdfs:label "is sequentially aligned with" ; rdfs:subPropertyOf obo:RO_0002514 . obo:RO_0002522 obo:IAO_0000112 "The genomic exons of a transcript bound the sequence of the genomic introns of the same transcript (but the introns are not subsequences of the exons)" ; obo:IAO_0000115 "x bounds the sequence of y iff the upstream-most part of x is upstream of or coincident with the upstream-most part of y, and the downstream-most part of x is downstream of or coincident with the downstream-most part of y" ; obo:IAO_0000117 "Chris Mungall" ; cito:citesAsAuthority ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "bounds sequence of" ; rdfs:subPropertyOf obo:RO_0002514 ; owl:inverseOf obo:RO_0002523 . obo:RO_0002523 obo:IAO_0000115 "inverse of bounds sequence of" ; obo:IAO_0000117 "Chris Mungall" ; cito:citesAsAuthority ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "is bound by sequence of" ; rdfs:subPropertyOf obo:RO_0002514 . obo:RO_0002524 obo:IAO_0000115 "x has subsequence y iff all of the sequence parts of x are sequence parts of y" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "contains" ; obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ; cito:citesAsAuthority ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "has subsequence" ; rdfs:subPropertyOf obo:BFO_0000051, obo:RO_0002522, obo:RO_0002526 ; owl:inverseOf obo:RO_0002525 . obo:RO_0002525 obo:IAO_0000115 "inverse of has subsequence" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "contained by" ; cito:citesAsAuthority ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "is subsequence of" ; rdfs:subPropertyOf obo:BFO_0000050, obo:RO_0002523, obo:RO_0002526 . obo:RO_0002526 obo:IAO_0000115 "x overlaps the sequence of x if and only if x has a subsequence z and z is a subsequence of y." ; obo:IAO_0000117 "Chris Mungall" ; cito:citesAsAuthority ; a owl:ObjectProperty, owl:SymmetricProperty ; rdfs:label "overlaps sequence of" ; rdfs:subPropertyOf obo:RO_0002131, obo:RO_0002514 ; owl:propertyChainAxiom (obo:RO_0002524 obo:RO_0002525 ) . obo:RO_0002527 obo:IAO_0000115 "x does not overlaps the sequence of x if and only if there is no z such that x has a subsequence z and z is a subsequence of y." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "disconnected from" ; cito:citesAsAuthority ; a owl:ObjectProperty, owl:SymmetricProperty ; rdfs:label "does not overlap sequence of" ; rdfs:subPropertyOf obo:RO_0002514 . obo:RO_0002528 obo:IAO_0000115 "inverse of downstream of sequence of" ; obo:IAO_0000117 "Chris Mungall" ; cito:citesAsAuthority ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "is upstream of sequence of" ; rdfs:subPropertyOf obo:RO_0002527 . obo:RO_0002529 obo:IAO_0000115 "x is downstream of the sequence of y iff either (1) x and y have sequence units, and all units of x are downstream of all units of y, or (2) x and y are sequence units, and x is either immediately downstream of y, or transitively downstream of y." ; obo:IAO_0000117 "Chris Mungall" ; cito:citesAsAuthority ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "is downstream of sequence of" ; rdfs:subPropertyOf obo:RO_0002527 ; owl:inverseOf obo:RO_0002529 . obo:RO_0002530 obo:IAO_0000112 "A 3'UTR is immediately downstream of the sequence of the CDS from the same monocistronic transcript" ; obo:IAO_0000115 "x is immediately downstream of the sequence of y iff either (1) x and y have sequence units, and all units of x are downstream of all units of y, and x is sequentially adjacent to y, or (2) x and y are sequence units, in which case the immediately downstream relation is primitive and defined by context: for DNA bases, y would be adjacent and 5' to y" ; obo:IAO_0000117 "Chris Mungall" ; obo:RO_0002575 obo:RO_0002529 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:label "is immediately downstream of sequence of" ; rdfs:subPropertyOf obo:RO_0002515, obo:RO_0002529 . obo:RO_0002531 obo:IAO_0000112 "A 5'UTR is immediately upstream of the sequence of the CDS from the same monocistronic transcript" ; obo:IAO_0000115 "inverse of immediately downstream of" ; obo:IAO_0000117 "Chris Mungall" ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:label "is immediately upstream of sequence of" ; rdfs:subPropertyOf obo:RO_0002515, obo:RO_0002528 . obo:RO_0002532 obo:IAO_0000115 "Any entity that is ordered in discrete units along a linear axis." ; obo:IAO_0000117 "Chris Mungall" ; a owl:Class ; rdfs:label "sequentially ordered entity" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002524 ; owl:someValuesFrom obo:RO_0002533 ] . obo:RO_0002533 obo:IAO_0000115 "Any individual unit of a collection of like units arranged in a linear order" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "An individual unit can be a molecular entity such as a base pair, or an abstract entity, such as the abstraction of a base pair." ; a owl:Class ; rdfs:label "sequence atomic unit" ; rdfs:subClassOf obo:RO_0002532 . obo:RO_0002534 obo:IAO_0000115 "Any entity that can be divided into parts such that each part is an atomical unit of a sequence" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "Sequence bearers can be molecular entities, such as a portion of a DNA molecule, or they can be abstract entities, such as an entity representing all human sonic hedgehog regions of the genome with a particular DNA sequence." ; a owl:Class ; rdfs:label "sequence bearer" ; rdfs:subClassOf obo:RO_0002532 . obo:RO_0002535 obo:IAO_0000232 "This properties were created originally for the annotation of developmental or life cycle stages, such as for example Carnegie Stage 20 in humans. " ; a owl:AnnotationProperty ; rdfs:label "temporal logical macro assertion on a class" ; rdfs:subPropertyOf obo:RO_0002420 . obo:RO_0002536 a owl:AnnotationProperty ; rdfs:label "measurement property has unit" ; rdfs:subPropertyOf obo:RO_0002423 . obo:RO_0002537 a owl:AnnotationProperty ; rdfs:label "has start time value" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002535 . obo:RO_0002538 a owl:AnnotationProperty ; rdfs:label "has end time value" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002535 . obo:RO_0002539 obo:IAO_0000115 "Count of number of days intervening between the start of the stage and the time of fertilization according to a reference model. Note that the first day of development has the value of 0 for this property." ; a owl:AnnotationProperty ; rdfs:label "start, days post fertilization" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002537 . obo:RO_0002540 obo:IAO_0000115 "Count of number of days intervening between the end of the stage and the time of fertilization according to a reference model. Note that the first day of development has the value of 1 for this property." ; a owl:AnnotationProperty ; rdfs:label "end, days post fertilization" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002538 . obo:RO_0002541 obo:IAO_0000115 "Count of number of years intervening between the start of the stage and the time of birth according to a reference model. Note that the first year of post-birth development has the value of 0 for this property, and the period during which the child is one year old has the value 1." ; a owl:AnnotationProperty ; rdfs:label "start, years post birth" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002537 . obo:RO_0002542 obo:IAO_0000115 "Count of number of years intervening between the end of the stage and the time of birth according to a reference model. Note that the first year of post-birth development has the value of 1 for this property, and the period during which the child is one year old has the value 2" ; a owl:AnnotationProperty ; rdfs:label "end, years post birth" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002538 . obo:RO_0002543 obo:IAO_0000115 "Count of number of months intervening between the start of the stage and the time of birth according to a reference model. Note that the first month of post-birth development has the value of 0 for this property, and the period during which the child is one month old has the value 1." ; a owl:AnnotationProperty ; rdfs:label "start, months post birth" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002537 . obo:RO_0002544 obo:IAO_0000115 "Count of number of months intervening between the end of the stage and the time of birth according to a reference model. Note that the first month of post-birth development has the value of 1 for this property, and the period during which the child is one month old has the value 2" ; a owl:AnnotationProperty ; rdfs:label "end, months post birth" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002538 . obo:RO_0002545 obo:IAO_0000115 "Defines the start and end of a stage with a duration of 1 month, relative to either the time of fertilization or last menstrual period of the mother (to be clarified), counting from one, in terms of a reference model. Thus if month_of_gestation=3, then the stage is 2 month in." ; a owl:AnnotationProperty ; rdfs:label "month of gestation" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002535 . obo:RO_0002546 obo:IAO_0000115 "A relationship between a stage class and an anatomical structure or developmental process class, in which the stage is characterized by the appearance of the structure or the occurrence of the biological process" ; a owl:AnnotationProperty ; rdfs:label "has developmental stage marker" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002535 . obo:RO_0002547 obo:IAO_0000115 "Count of number of days intervening between the start of the stage and the time of coitum." ; obo:IAO_0000232 "For mouse staging: assuming that it takes place around midnight during a 7pm to 5am dark cycle (noon of the day on which the vaginal plug is found, the embryos are aged 0.5 days post coitum)" ; a owl:AnnotationProperty ; rdfs:label "start, days post coitum" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002537 . obo:RO_0002548 obo:IAO_0000115 "Count of number of days intervening between the end of the stage and the time of coitum." ; a owl:AnnotationProperty ; rdfs:label "end, days post coitum" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002538 . obo:RO_0002549 a owl:AnnotationProperty ; rdfs:label "start, weeks post birth" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002537 . obo:RO_0002550 a owl:AnnotationProperty ; rdfs:label "end, weeks post birth" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002538 . obo:RO_0002551 obo:IAO_0000112 "Forelimb SubClassOf has_skeleton some 'Forelimb skeleton'" ; obo:IAO_0000115 "A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000118 "has supporting framework" ; obo:IAO_0000232 "The skeleton of a structure may be a true skeleton (for example, the bony skeleton of a hand) or any kind of support framework (the hydrostatic skeleton of a sea star, the exoskeleton of an insect, the cytoskeleton of a cell)." ; a owl:AsymmetricProperty, owl:IrreflexiveProperty, owl:ObjectProperty ; rdfs:domain obo:CARO_0000003 ; rdfs:label "has skeleton" ; rdfs:range obo:CARO_0000006 ; rdfs:subPropertyOf obo:BFO_0000051 ; owl:inverseOf obo:RO_0002576 . obo:RO_0002552 obo:IAO_0000115 "p results in the end of s if p results in a change of state in s whereby s either ceases to exist, or s becomes functionally impaired or s has its fate committed such that it is put on a path to be degraded." ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "results in ending of" ; rdfs:subPropertyOf obo:RO_0002295, obo:RO_0040036 . obo:RO_0002553 obo:IAO_0000115 "x is a hyperparasite of y iff x is a parasite of a parasite of the target organism y" ; obo:IAO_0000116 "Note that parasite-of is a diret relationship, so hyperparasite-of is not considered a sub-relation, even though hyperparasitism can be considered a form of parasitism" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://eol.org/schema/terms/hyperparasitoidOf", "https://en.wikipedia.org/wiki/Hyperparasite" ; oboInOwl:hasRelatedSynonym "epiparasite of", "hyperparasitoid of" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "hyperparasite of" ; rdfs:subPropertyOf obo:RO_0002454 ; owl:inverseOf obo:RO_0002554 ; owl:propertyChainAxiom (obo:RO_0002444 obo:RO_0002444 ) . obo:RO_0002554 obo:IAO_0000115 "inverse of hyperparasite of" ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:hasRelatedSynonym "has epiparasite", "has hyperparasite", "hyperparasitoidized by" ; oboInOwl:inSubset obo:RO_0002259, subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "hyperparasitized by" ; rdfs:subPropertyOf obo:RO_0002453 ; owl:propertyChainAxiom (obo:RO_0002445 obo:RO_0002445 ) . obo:RO_0002555 obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Allelopathy" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "allelopath of" ; rdfs:seeAlso "http://eol.org/schema/terms/allelopathyYes", "x is an allelopath of y iff xis an organism produces one or more biochemicals that influence the growth, survival, and reproduction of y" ; rdfs:subPropertyOf obo:RO_0002574 . obo:RO_0002556 obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "pathogen of" ; rdfs:subPropertyOf obo:RO_0002454 ; owl:inverseOf obo:RO_0002557 . obo:RO_0002557 obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "has pathogen" ; rdfs:subPropertyOf obo:RO_0002453 . obo:RO_0002558 obo:IAO_0000115 "inverse of is evidence for" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 ; oboInOwl:inSubset obo:RO_0002259, subsets:ro-eco ; a owl:ObjectProperty ; rdfs:comment "x has evidence y iff , x is an information content entity, material entity or process, and y supports either the existence of x, or the truth value of x." ; rdfs:label "has evidence" ; rdfs:subPropertyOf obo:RO_0002616 . obo:RO_0002559 obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 ; obo:IAO_0000589 "causally influenced by (entity-centric)" ; a owl:ObjectProperty ; rdfs:label "causally influenced by" ; rdfs:subPropertyOf obo:RO_0002506 ; owl:inverseOf obo:RO_0002566 . obo:RO_0002560 obo:IAO_0000115 "If Rel is the relational form of a process Pr, then it follow that: Rel(x,y) <-> exists p : Pr(p), x subject-partner-in p, y object-partner-in p" ; a owl:AnnotationProperty ; rdfs:label "is asymmetric relational form of process class" ; rdfs:seeAlso "http://purl.obolibrary.org/obo/ro/docs/interaction-relations/"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002562 . obo:RO_0002561 obo:IAO_0000115 "If Rel is the relational form of a process Pr, then it follow that: Rel(x,y) <-> exists p : Pr(p), x partner-in p, y partner-in p" ; a owl:AnnotationProperty ; rdfs:label "is symmetric relational form of process class" ; rdfs:seeAlso "http://purl.obolibrary.org/obo/ro/docs/interaction-relations/"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002562 . obo:RO_0002562 obo:IAO_0000115 "R is the relational form of a process if and only if either (1) R is the symmetric relational form of a process or (2) R is the asymmetric relational form of a process" ; a owl:AnnotationProperty ; rdfs:label "is relational form of process class" ; rdfs:seeAlso "http://purl.obolibrary.org/obo/ro/docs/interaction-relations/"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002594 . obo:RO_0002563 obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "interaction relation helper property" ; rdfs:seeAlso , "http://purl.obolibrary.org/obo/ro/docs/interaction-relations/"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002464 . obo:RO_0002564 obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "molecular interaction relation helper property" ; rdfs:subPropertyOf obo:RO_0002563 . obo:RO_0002565 obo:IAO_0000115 "Holds between p and c when p is locomotion process and the outcome of this process is the change of location of c" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "" ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "results in movement of" ; rdfs:subPropertyOf obo:RO_0040036 . obo:RO_0002566 obo:IAO_0000115 "The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size)." ; obo:IAO_0000117 "Chris Mungall", "Vasundra Touré" ; obo:IAO_0000119 ; obo:IAO_0000589 "causally influences (entity-centric)" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000002 ; rdfs:label "causally influences" ; rdfs:range obo:BFO_0000002 ; rdfs:subPropertyOf obo:RO_0002506 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002411 obo:RO_0002233 ), (obo:RO_0002327 obo:RO_0002411 obo:RO_0002333 ) . obo:RO_0002567 obo:IAO_0000115 "A relation that holds between elements of a musculoskeletal system or its analogs." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the biomechanical processes." ; a owl:ObjectProperty ; rdfs:domain obo:CARO_0000003 ; rdfs:label "biomechanically related to" ; rdfs:range obo:CARO_0000003 ; rdfs:subPropertyOf obo:RO_0002328 . obo:RO_0002568 obo:IAO_0000115 "m1 has_muscle_antagonist m2 iff m1 has_muscle_insertion s, m2 has_muscle_insection s, m1 acts in opposition to m2, and m2 is responsible for returning the structure to its initial position." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "Wikipedia:Antagonist_(muscle)" ; a owl:ObjectProperty ; rdfs:label "has muscle antagonist" ; rdfs:subPropertyOf obo:RO_0002567 . obo:RO_0002569 obo:IAO_0000115 "inverse of branching part of" ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset obo:RO_0002259, subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "has branching part" ; rdfs:subPropertyOf obo:RO_0002375 . obo:RO_0002570 obo:IAO_0000115 "x is a conduit for y iff y overlaps through the lumen_of of x, and y has parts on either side of the lumen of x." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "UBERON:cjm" ; obo:IAO_0000232 "This relation holds between a thing with a 'conduit' (e.g. a bone foramen) and a 'conduee' (for example, a nerve) such that at the time the relationship holds, the conduee has two ends sticking out either end of the conduit. It should therefore note be used for objects that move through the conduit but whose spatial extent does not span the passage. For example, it would not be used for a mountain that contains a long tunnel through which trains pass. Nor would we use it for a digestive tract and objects such as food that pass through." ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "conduit for" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0002131 . obo:RO_0002571 obo:IAO_0000115 "x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "GOC:cjm" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "lumen of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:BFO_0000050 . obo:RO_0002572 obo:IAO_0000115 "s is luminal space of x iff s is lumen_of x and s is an immaterial entity" ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000141 ; rdfs:label "luminal space of" ; rdfs:subPropertyOf obo:RO_0002571 . obo:RO_0002573 obo:IAO_0000115 "A relation that holds between an attribute or a qualifier and another attribute." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 ; obo:IAO_0000232 "This relation is intended to be used in combination with PATO, to be able to refine PATO quality classes using modifiers such as 'abnormal' and 'normal'. It has yet to be formally aligned into an ontological framework; it's not clear what the ontological status of the \"modifiers\" are." ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000020 ; rdfs:label "has modifier" ; rdfs:range obo:BFO_0000020 . obo:RO_0002574 obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain obo:CARO_0001010 ; rdfs:label "participates in a biotic-biotic interaction with" ; rdfs:range obo:CARO_0001010 ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002437 . obo:RO_0002575 obo:IAO_0000115 "relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y" ; obo:IAO_0000116 """The general property hierarchy is: \"directly P\" SubPropertyOf \"P\" Transitive(P) Where we have an annotation assertion \"directly P\" \"is direct form of\" \"P\"""" ; obo:RO_0002423 "If we have the annotation P is-direct-form-of Q, and we have inverses P' and Q', then it follows that P' is-direct-form-of Q'" ; terms:creator "Chris Mungall" ; a owl:AnnotationProperty ; rdfs:label "is direct form of" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002422 . obo:RO_0002576 obo:IAO_0000115 "inverse of has skeleton" ; obo:IAO_0000117 "Chris Mungall" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:domain obo:CARO_0000003 ; rdfs:label "skeleton of" ; rdfs:range obo:CARO_0000003 ; rdfs:subPropertyOf obo:BFO_0000050 . obo:RO_0002577 obo:IAO_0000115 "A material entity consisting of multiple components that are causally integrated." ; obo:IAO_0000116 "May be replaced by a BFO class, as discussed in http://www.jbiomedsem.com/content/4/1/43" ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 "http://www.jbiomedsem.com/content/4/1/43" ; rdfs:label "system" ; rdfs:subClassOf obo:BFO_0000040 . obo:RO_0002578 obo:IAO_0000115 "Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 ; obo:IAO_0000589 "directly regulates (processual)" ; obo:RO_0002575 obo:RO_0002211 ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "directly regulates" ; rdfs:subPropertyOf obo:RO_0002211, obo:RO_0002412 . obo:RO_0002579 obo:IAO_0000115 "relation p is the indirect form of relation q iff p is a subPropertyOf q, and there exists some p' such that p' is the direct form of q, p' o p' -> p, and forall x,y : x q y -> either (1) x p y or (2) x p' y" ; terms:creator "Chris Mungall" ; a owl:AnnotationProperty ; rdfs:label "is indirect form of" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002422 . obo:RO_0002580 a owl:AnnotationProperty ; rdfs:label "logical macro assertion on an axiom" ; rdfs:subPropertyOf obo:RO_0002416 . obo:RO_0002581 obo:IAO_0000115 "If R <- P o Q is a defining property chain axiom, then it also holds that R -> P o Q. Note that this cannot be expressed directly in OWL" ; a owl:AnnotationProperty ; rdfs:label "is a defining property chain axiom" ; rdfs:subPropertyOf obo:RO_0002580 . obo:RO_0002582 obo:IAO_0000115 "If R <- P o Q is a defining property chain axiom, then (1) R -> P o Q holds and (2) Q is either reflexive or locally reflexive. A corollary of this is that P SubPropertyOf R." ; a owl:AnnotationProperty ; rdfs:label "is a defining property chain axiom where second argument is reflexive" ; rdfs:subPropertyOf obo:RO_0002581 . obo:RO_0002583 obo:IAO_0000115 "holds between x and y if and only if the time point at which x starts is equivalent to the time point at which y ends. Formally: iff α(x) = ω(y)." ; a owl:ObjectProperty ; rdfs:label "existence starts at end of" ; rdfs:subPropertyOf obo:RO_0002496 . obo:RO_0002584 obo:IAO_0000112 "gland SubClassOf 'has part structure that is capable of' some 'secretion by cell'" ; obo:IAO_0000115 "s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p" ; obo:IAO_0000117 "Chris Mungall" ; a owl:ObjectProperty ; rdfs:label "has part structure that is capable of" ; rdfs:subPropertyOf obo:RO_0002328, obo:RO_0002595 ; owl:propertyChainAxiom (obo:BFO_0000051 obo:RO_0002215 ) . obo:RO_0002585 obo:IAO_0000116 "p 'results in closure of' c if and only if p is a developmental process and p results in a state of c changing from open to closed." ; a owl:ObjectProperty ; rdfs:label "results in closure of" ; rdfs:subPropertyOf obo:RO_0002295, obo:RO_0040036 . obo:RO_0002586 obo:IAO_0000115 "p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p" ; a owl:ObjectProperty ; rdfs:label "results in breakdown of" ; rdfs:subPropertyOf obo:RO_0002233 . obo:RO_0002587 a owl:ObjectProperty ; rdfs:label "results in synthesis of" ; rdfs:subPropertyOf obo:RO_0002297 . obo:RO_0002588 oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "results in assembly of" ; rdfs:subPropertyOf obo:RO_0002297, obo:RO_0002592 . obo:RO_0002589 obo:IAO_0000115 "p results in catabolism of c if and only if p is a catabolic process, and the execution of p results in c being broken into smaller parts with energy being released." ; a owl:ObjectProperty ; rdfs:label "results in catabolism of" ; rdfs:subPropertyOf obo:RO_0002586 . obo:RO_0002590 a owl:ObjectProperty ; rdfs:label "results in disassembly of" ; rdfs:subPropertyOf obo:RO_0002586, obo:RO_0002592 . obo:RO_0002591 a owl:ObjectProperty ; rdfs:label "results in remodeling of" ; rdfs:subPropertyOf obo:RO_0002233, obo:RO_0002592 . obo:RO_0002592 obo:IAO_0000115 "p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c" ; a owl:ObjectProperty ; rdfs:label "results in organization of" ; rdfs:subPropertyOf obo:RO_0040036 . obo:RO_0002593 obo:IAO_0000115 "holds between x and y if and only if the time point at which x ends is equivalent to the time point at which y starts. Formally: iff ω(x) = α(y)." ; a owl:ObjectProperty ; rdfs:label "existence ends at start of" ; rdfs:subPropertyOf obo:RO_0002497 . obo:RO_0002594 obo:IAO_0000115 "An annotation property that connects an object property to a class, where the object property is derived from or a shortcut property for the class. The exact semantics of this annotation may vary on a case by case basis." ; a owl:AnnotationProperty ; rdfs:label "is relational form of a class" ; rdfs:subPropertyOf obo:RO_0002422 . obo:RO_0002595 obo:IAO_0000115 "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." ; obo:IAO_0000116 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." ; obo:IAO_0000117 "Chris Mungall" ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "causal relation between material entity and a process" ; rdfs:range obo:BFO_0000015 ; rdfs:subPropertyOf obo:RO_0002410 . obo:RO_0002596 obo:IAO_0000112 "pyrethroid -> growth" ; obo:IAO_0000115 "Holds between c and p if and only if c is capable of some activity a, and a regulates p." ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "capable of regulating" ; rdfs:subPropertyOf obo:RO_0002500 ; owl:propertyChainAxiom (obo:RO_0002215 obo:RO_0002211 ) . obo:RO_0002597 obo:IAO_0000115 "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p." ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "capable of negatively regulating" ; rdfs:subPropertyOf obo:RO_0002596 ; owl:propertyChainAxiom (obo:RO_0002215 obo:RO_0002212 ) . obo:RO_0002598 obo:IAO_0000112 "renin -> arteriolar smooth muscle contraction" ; obo:IAO_0000115 "Holds between c and p if and only if c is capable of some activity a, and a positively regulates p." ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "capable of positively regulating" ; rdfs:subPropertyOf obo:RO_0002596 ; owl:propertyChainAxiom (obo:RO_0002215 obo:RO_0002213 ) . obo:RO_0002599 obo:IAO_0000112 "pazopanib -> pathological angiogenesis" ; obo:IAO_0000115 "Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a inhibits p." ; obo:IAO_0000118 "treats" ; obo:IAO_0000119 ; obo:IAO_0000232 "The entity c may be a molecular entity with a drug role, or it could be some other entity used in a therapeutic context, such as a hyperbaric chamber." ; a owl:ObjectProperty ; rdfs:label "capable of inhibiting or preventing pathological process" ; rdfs:subPropertyOf obo:RO_0002597 . obo:RO_0002600 obo:IAO_0000112 "benzene -> cancer [CHEBI]" ; obo:IAO_0000115 "Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a negatively regulates p." ; obo:IAO_0000118 "causes disease" ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "capable of upregulating or causing pathological process" ; rdfs:subPropertyOf obo:RO_0002598 . obo:RO_0002601 obo:IAO_0000115 "A shortcut relationship that holds between two entities based on their identity criteria" ; a owl:AnnotationProperty ; rdfs:label "logical macro assertion involving identity" ; rdfs:subPropertyOf obo:RO_0002416 . obo:RO_0002602 obo:IAO_0000115 "A shortcut relationship between two entities x and y1, such that the intent is that the relationship is functional and inverse function, but there is no guarantee that this property holds." ; a owl:AnnotationProperty ; rdfs:label "in approximate one to one relationship with" ; rdfs:subPropertyOf obo:RO_0002601 . obo:RO_0002603 obo:IAO_0000115 "x is approximately equivalent to y if it is the case that x is equivalent, identical or near-equivalent to y" ; obo:IAO_0000232 "The precise meaning of this property is dependent upon some contexts. It is intended to group multiple possible formalisms. Possibilities include a probabilistic interpretation, for example, Pr(x=y) > 0.95. Other possibilities include reified statements of belief, for example, \"Database D states that x=y\"" ; a owl:AnnotationProperty ; rdfs:label "is approximately equivalent to" ; rdfs:subPropertyOf obo:RO_0002602 . obo:RO_0002604 obo:IAO_0000112 "'anterior end of organism' is-opposite-of 'posterior end of organism'", "'increase in temperature' is-opposite-of 'decrease in temperature'" ; obo:IAO_0000115 "x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x)." ; a owl:AnnotationProperty ; rdfs:label "is opposite of" ; rdfs:subPropertyOf obo:RO_0002602 . obo:RO_0002605 obo:IAO_0000115 "x is indistinguishable from y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x)." ; a owl:AnnotationProperty ; rdfs:label "is indistinguishable from" ; rdfs:subPropertyOf obo:RO_0002603 . obo:RO_0002606 obo:IAO_0000115 "c is a substance that treats d if c is a material entity (such as a small molecule or compound) and d is a pathological process, phenotype or disease, and c is capable of some activity that negative regulates or decreases the magnitude of d." ; obo:IAO_0000118 "treats" ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "is substance that treats" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002599 . obo:RO_0002607 obo:IAO_0000115 "c is marker for d iff the presence or occurrence of d is correlated with the presence of occurrence of c, and the observation of c is used to infer the presence or occurrence of d. Note that this does not imply that c and d are in a direct causal relationship, as it may be the case that there is a third entity e that stands in a direct causal relationship with c and d." ; obo:IAO_0000116 "May be ceded to OBI" ; a owl:ObjectProperty ; rdfs:label "is marker for" ; rdfs:subPropertyOf obo:RO_0002610 . obo:RO_0002608 obo:IAO_0000115 "Inverse of 'causal agent in process'" ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "process has causal agent" ; rdfs:subPropertyOf obo:RO_0002410 . obo:RO_0002609 obo:IAO_0000115 "A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." ; obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." ; a owl:ObjectProperty ; rdfs:label "obsolete related via dependence to"^^xsd:string ; owl:deprecated true . obo:RO_0002610 obo:IAO_0000115 "A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." ; obo:IAO_0000232 "Groups both positive and negative correlation" ; a owl:ObjectProperty ; rdfs:label "correlated with" . obo:RO_0002611 a owl:AnnotationProperty ; rdfs:label "evidential logical macro assertion on an axiom" ; rdfs:subPropertyOf obo:RO_0002580 . obo:RO_0002612 obo:IAO_0000115 "A relationship between a sentence and an instance of a piece of evidence in which the evidence supports the axiom" ; obo:IAO_0000232 "This annotation property is intended to be used in an OWL Axiom Annotation to connect an OWL Axiom to an instance of an ECO (evidence type ontology class). Because in OWL, all axiom annotations must use an Annotation Property, the value of the annotation cannot be an OWL individual, the convention is to use an IRI of the individual." ; a owl:AnnotationProperty ; rdfs:label "axiom has evidence" ; rdfs:subPropertyOf obo:RO_0002611 . obo:RO_0002613 obo:IAO_0000115 "A relationship between a sentence and an instance of a piece of evidence in which the evidence contradicts the axiom" ; obo:IAO_0000232 "This annotation property is intended to be used in an OWL Axiom Annotation to connect an OWL Axiom to an instance of an ECO (evidence type ontology class). Because in OWL, all axiom annotations must use an Annotation Property, the value of the annotation cannot be an OWL individual, the convention is to use an IRI of the individual." ; a owl:AnnotationProperty ; rdfs:label "axiom contradicted by evidence" ; rdfs:subPropertyOf obo:RO_0002611 . obo:RO_0002614 obo:IAO_0000112 "An instance of a sequence similarity evidence (ECO:0000044) that uses a homologous sequence UniProtKB:P12345 as support." ; obo:IAO_0000115 "A relationship between a piece of evidence and an entity that plays a role in supporting that evidence." ; a owl:ObjectProperty ; rdfs:comment "In the Gene Ontology association model, this corresponds to the With/From field" ; rdfs:label "is evidence with support from" ; rdfs:subPropertyOf obo:RO_0002616 . obo:RO_0002615 obo:IAO_0000115 "Inverse of is-model-of" ; a owl:ObjectProperty ; rdfs:label "has model" ; owl:inverseOf obo:RO_0003301 . obo:RO_0002616 obo:IAO_0000232 "Do not use this relation directly. It is a grouping relation." ; a owl:ObjectProperty ; rdfs:label "related via evidence or inference to" . obo:RO_0002617 obo:IAO_0000112 "In the context of a particular project, the IRI with CURIE NCBIGene:64327 (which in this example denotes a class) is considered to be representative. This means that if we have equivalent classes with IRIs OMIM:605522, ENSEMBL:ENSG00000105983, HGNC:13243 forming an equivalence set, the NCBIGene is considered the representative member IRI. Depending on the policies of the project, the classes may be merged, or the NCBIGene IRI may be chosen as the default in a user interface context." ; obo:IAO_0000115 "this property relates an IRI to the xsd boolean value \"True\" if the IRI is intended to be the representative IRI for a collection of classes that are mutually equivalent." ; obo:IAO_0000232 "If it is necessary to make the context explicit, an axiom annotation can be added to the annotation assertion" ; a owl:AnnotationProperty ; rdfs:label "is representative IRI for equivalence set" ; rdfs:seeAlso "OWLAPI Reasoner documentation for representativeElement, which follows a similar idea, but selects an arbitrary member" ; rdfs:subPropertyOf obo:RO_0002601 . obo:RO_0002618 a owl:ObjectProperty ; rdfs:label "visits" ; rdfs:seeAlso "https://github.com/oborel/obo-relations/issues/74"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002574 ; owl:inverseOf obo:RO_0002619 . obo:RO_0002619 a owl:ObjectProperty ; rdfs:label "visited by" ; rdfs:subPropertyOf obo:RO_0002574 . obo:RO_0002622 a owl:ObjectProperty ; rdfs:label "visits flowers of" ; rdfs:subPropertyOf obo:RO_0002618 ; owl:inverseOf obo:RO_0002623 . obo:RO_0002623 a owl:ObjectProperty ; rdfs:label "has flowers visited by" ; rdfs:subPropertyOf obo:RO_0002619 . obo:RO_0002624 a owl:ObjectProperty ; rdfs:label "lays eggs in" ; rdfs:subPropertyOf obo:RO_0002444, obo:RO_0002618 ; owl:inverseOf obo:RO_0002625 . obo:RO_0002625 a owl:ObjectProperty ; rdfs:label "has eggs laid in by" ; rdfs:subPropertyOf obo:RO_0002445, obo:RO_0002619 . obo:RO_0002626 obo:IAO_0000119 "https://github.com/jhpoelen/eol-globi-data/issues/143" ; a owl:ObjectProperty ; rdfs:label "kills" ; rdfs:subPropertyOf obo:RO_0002574 ; owl:inverseOf obo:RO_0002627 . obo:RO_0002627 a owl:ObjectProperty ; rdfs:label "is killed by" ; rdfs:subPropertyOf obo:RO_0002574 . obo:RO_0002629 obo:IAO_0000115 "Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2." ; obo:IAO_0000119 ; obo:IAO_0000589 "directly positively regulates (process to process)" ; obo:RO_0004049 obo:RO_0002578 ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "directly positively regulates" ; rdfs:subPropertyOf obo:RO_0002213, obo:RO_0002578 . obo:RO_0002630 obo:IAO_0000115 "Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2." ; obo:IAO_0000119 ; obo:IAO_0000589 "directly negatively regulates (process to process)" ; obo:RO_0004050 obo:RO_0002578 ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "directly negatively regulates" ; rdfs:subPropertyOf obo:RO_0002212, obo:RO_0002578 . obo:RO_0002632 obo:IAO_0000115 "A sub-relation of parasite-of in which the parasite lives on or in the integumental system of the host" ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "ectoparasite of" ; rdfs:subPropertyOf obo:RO_0002444 ; owl:inverseOf obo:RO_0002633 . obo:RO_0002633 obo:IAO_0000115 "inverse of ectoparasite of" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "has ectoparasite" ; rdfs:subPropertyOf obo:RO_0002445 . obo:RO_0002634 obo:IAO_0000119 , "A sub-relation of parasite-of in which the parasite lives inside the host, beneath the integumental system" ; oboInOwl:hasRelatedSynonym "lives inside of" ; a owl:ObjectProperty ; rdfs:label "endoparasite of" ; rdfs:subPropertyOf obo:RO_0002444 ; owl:inverseOf obo:RO_0002635 . obo:RO_0002635 a owl:ObjectProperty ; rdfs:label "has endoparasite" ; rdfs:subPropertyOf obo:RO_0002445 . obo:RO_0002636 obo:IAO_0000115 "A sub-relation of parasite-of in which the parasite is partially an endoparasite and partially an ectoparasite" ; a owl:ObjectProperty ; rdfs:label "mesoparasite of" ; rdfs:subPropertyOf obo:RO_0002444 ; owl:inverseOf obo:RO_0002637 . obo:RO_0002637 obo:IAO_0000115 "inverse of mesoparasite of" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "has mesoparasite" ; rdfs:subPropertyOf obo:RO_0002445 . obo:RO_0002638 obo:IAO_0000115 "A sub-relation of endoparasite-of in which the parasite inhabits the spaces between host cells." ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "intercellular endoparasite of" ; rdfs:subPropertyOf obo:RO_0002634 ; owl:inverseOf obo:RO_0002639 . obo:RO_0002639 obo:IAO_0000115 "inverse of intercellular endoparasite of" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "has intercellular endoparasite" ; rdfs:subPropertyOf obo:RO_0002635 . obo:RO_0002640 obo:IAO_0000115 "A sub-relation of endoparasite-of in which the parasite inhabits host cells." ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "intracellular endoparasite of" ; rdfs:subPropertyOf obo:RO_0002634 ; owl:inverseOf obo:RO_0002641 . obo:RO_0002641 obo:IAO_0000115 "inverse of intracellular endoparasite of" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "has intracellular endoparasite" ; rdfs:subPropertyOf obo:RO_0002635 . obo:RO_0002801 obo:IAO_0000115 "Two or more individuals sharing the same roost site (cave, mine, tree or tree hollow, animal burrow, leaf tent, rock crack, space in man-made structure, etc.). Individuals that are sharing a communal roost may be said to be co-roosting. The roost may be either a day roost where the individuals rest during daytime hours, or a night roost where individuals roost to feed, groom, or rest in between flights and/or foraging bouts. Communal roosting as thus defined is an umbrella term within which different specialized types -- which are not mutually exclusive -- may be recognized based on taxonomy and the temporal and spatial relationships of the individuals that are co-roosting."@en ; obo:IAO_0000119 ; a owl:ObjectProperty, owl:SymmetricProperty ; rdfs:label "co-roosts with"@en ; rdfs:subPropertyOf obo:RO_0008506 . obo:RO_0003000 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix."^^xsd:string ; obo:IAO_0000117 "Melissa Haendel" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:comment "Note that this definition doesn't quite distinguish the output of a transformation process from a production process, which is related to the identity/granularity issue."^^xsd:string ; rdfs:domain obo:BFO_0000040 ; rdfs:label "produces"@en ; rdfs:range obo:BFO_0000040 ; owl:inverseOf obo:RO_0003001 ; owl:propertyChainAxiom ([ owl:inverseOf obo:BFO_0000066 ] obo:RO_0002234 ) . obo:RO_0003001 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a produced_by b iff some process that occurs_in b has_output a." ; obo:IAO_0000117 "Melissa Haendel" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "produced by"@en ; rdfs:range obo:BFO_0000040 . obo:RO_0003002 obo:IAO_0000115 "Holds between entity A (a transcription factor) and a nucleic acid B if and only if A down-regulates the expression of B. The nucleic acid can be a gene or an mRNA." ; obo:IAO_0000117 "Vasundra Touré" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "represses expression of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0002449 . obo:RO_0003003 obo:IAO_0000115 "Holds between entity A (a transcription factor) and nucleic acid B if and only if A up-regulates the expression of B. The nucleic acid can be a gene or mRNA." ; obo:IAO_0000117 "Vasundra Touré" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "increases expression of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0002450 . obo:RO_0003301 obo:IAO_0000115 "A relation between a biological, experimental, or computational artifact and an entity it is used to study, in virtue of its replicating or approximating features of the studied entity." ; obo:IAO_0000117 "Matthew Brush" ; obo:IAO_0000118 "is used to study"@en ; a owl:AsymmetricProperty, owl:IrreflexiveProperty, owl:ObjectProperty ; rdfs:comment "The primary use case for this relation was to link a biological model system such as a cell line or model organism to a disease it is used to investigate, in virtue of the model system exhibiting features similar to that of the disease of interest. But the relation is defined more broadly to support other use cases, such as linking genes in which alterations are made to create model systems to the condition the system is used to interrogate, or computational models to real-world phenomena they are defined to simulate." ; rdfs:label "has role in modeling"@en . obo:RO_0003302 obo:IAO_0000112 """The genetic variant 'NM_007294.3(BRCA1):c.110C>A (p.Thr37Lys)' casues or contributes to the disease 'familial breast-ovarian cancer'. An environment of exposure to arsenic causes or contributes to the phenotype of patchy skin hyperpigmentation, and the disease 'skin cancer'.""" ; obo:IAO_0000115 "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal or contributing role that influences the condition." ; obo:IAO_0000116 "Note that relationships of phenotypes to organisms/strains that bear them, or diseases they are manifest in, should continue to use RO:0002200 ! 'has phenotype' and RO:0002201 ! 'phenotype of'." ; a owl:ObjectProperty ; rdfs:comment """Genetic variations can span any level of granularity from a full genome or genotype to an individual gene or sequence alteration. These variations can be represented at the physical level (DNA/RNA macromolecules or their parts, as in the ChEBI ontology and Molecular Sequence Ontology) or at the abstract level (generically dependent continuant sequence features that are carried by these macromolecules, as in the Sequence Ontology and Genotype Ontology). The causal relations in this hierarchy can be used in linking either physical or abstract genetic variations to phenotypes or diseases they cause or contribute to. Environmental exposures include those imposed by natural environments, experimentally applied conditions, or clinical interventions.""" ; rdfs:label "causes or contributes to condition"@en ; rdfs:subPropertyOf obo:RO_0002410 . obo:RO_0003303 obo:IAO_0000115 "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal role for the condition." ; a owl:ObjectProperty ; rdfs:label "causes condition"@en ; rdfs:subPropertyOf obo:RO_0003302 . obo:RO_0003304 obo:IAO_0000115 "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some contributing role that influences the condition." ; a owl:ObjectProperty ; rdfs:label "contributes to condition"@en ; rdfs:subPropertyOf obo:RO_0003302 . obo:RO_0003305 obo:IAO_0000115 "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the severity with which a condition manifests in an individual." ; obo:IAO_0000118 "contributes to expressivity of condition" ; a owl:ObjectProperty ; rdfs:label "contributes to severity of condition"@en ; rdfs:subPropertyOf obo:RO_0003304 . obo:RO_0003306 obo:IAO_0000115 "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the frequency of the condition in a population." ; obo:IAO_0000118 "contributes to penetrance of condition" ; a owl:ObjectProperty ; rdfs:label "contributes to frequency of condition"@en ; rdfs:subPropertyOf obo:RO_0003304 . obo:RO_0003307 obo:IAO_0000115 "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition." ; obo:IAO_0000118 "is preventative for condition" ; a owl:ObjectProperty ; rdfs:comment """Genetic variations can span any level of granularity from a full genome or genotype to an individual gene or sequence alteration. These variations can be represented at the physical level (DNA/RNA macromolecules or their parts, as in the ChEBI ontology and Molecular Sequence Ontology) or at the abstract level (generically dependent continuant sequence features that are carried by these macromolecules, as in the Sequence Ontology and Genotype Ontology). The causal relations in this hierarchy can be used in linking either physical or abstract genetic variations to phenotypes or diseases they cause or contribute to. Environmental exposures include those imposed by natural environments, experimentally applied conditions, or clinical interventions.""" ; rdfs:label "ameliorates condition"@en ; rdfs:subPropertyOf obo:RO_0003305 . obo:RO_0003308 obo:IAO_0000115 "A relationship between an entity and a condition (phenotype or disease) with which it exhibits a statistical dependence relationship." ; a owl:ObjectProperty ; rdfs:label "correlated with condition"@en ; rdfs:subPropertyOf obo:RO_0002610 . obo:RO_0003309 obo:IAO_0000115 "A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition." ; a owl:ObjectProperty ; rdfs:label "exacerbates condition"@en ; rdfs:subPropertyOf obo:RO_0003305 . obo:RO_0003310 obo:IAO_0000115 "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are reduced or eliminated by the presence of the entity." ; a owl:ObjectProperty ; rdfs:label "condition ameliorated by"@en ; rdfs:subPropertyOf obo:RO_0002410 . obo:RO_0003311 obo:IAO_0000115 "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are worsened by the presence of the entity." ; a owl:ObjectProperty ; rdfs:label "condition exacerbated by"@en ; rdfs:subPropertyOf obo:RO_0002410 . obo:RO_0004000 obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a more specific relations" ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T02:38:20Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000017 ; rdfs:label "condition has genetic basis in" ; rdfs:range [ a owl:Class ; owl:unionOf (obo:BFO_0000015 obo:BFO_0000019 obo:BFO_0000040 ) ] ; rdfs:subPropertyOf obo:RO_0002410 ; owl:inverseOf obo:RO_0004010 . obo:RO_0004001 oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T02:45:20Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "has material basis in gain of function germline mutation in" ; rdfs:seeAlso , ; rdfs:subPropertyOf obo:RO_0004000 ; owl:inverseOf obo:RO_0004011 . obo:RO_0004002 oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T02:45:37Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "has material basis in loss of function germline mutation in" ; rdfs:subPropertyOf obo:RO_0004000 ; owl:inverseOf obo:RO_0004012 . obo:RO_0004003 oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T02:45:54Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "has material basis in germline mutation in" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0004000 ; owl:inverseOf obo:RO_0004013 . obo:RO_0004004 oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T02:46:07Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "has material basis in somatic mutation in" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0004000 ; owl:inverseOf obo:RO_0004014 . obo:RO_0004005 oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T02:46:26Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "has major susceptibility factor" ; rdfs:subPropertyOf obo:RO_0004000 ; owl:inverseOf obo:RO_0004015 . obo:RO_0004006 oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T02:46:57Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "has partial material basis in germline mutation in" ; rdfs:subPropertyOf obo:RO_0004000 ; owl:inverseOf obo:RO_0004016 . obo:RO_0004007 obo:IAO_0000115 "p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2018-12-13T11:26:17Z"^^xsd:dateTime ; oboInOwl:inSubset obo:valid_for_go_ontology ; a owl:ObjectProperty ; rdfs:label "has primary input or output" ; rdfs:subPropertyOf obo:RO_0000057 . obo:RO_0004008 obo:IAO_0000115 "p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2018-12-13T11:26:32Z"^^xsd:dateTime ; oboInOwl:inSubset obo:valid_for_go_ontology ; a owl:ObjectProperty ; rdfs:label "has primary output" ; rdfs:subPropertyOf obo:RO_0002234, obo:RO_0004007 . obo:RO_0004009 obo:IAO_0000115 "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2018-12-13T11:26:56Z"^^xsd:dateTime ; oboInOwl:inSubset obo:valid_for_go_ontology ; a owl:ObjectProperty ; rdfs:label "has primary input" ; rdfs:subPropertyOf obo:RO_0002233, obo:RO_0004007 . obo:RO_0004010 obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a more specific relations" ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T02:53:08Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "is genetic basis for condition" ; rdfs:range obo:BFO_0000017 ; rdfs:subPropertyOf obo:RO_0004018 . obo:RO_0004011 obo:IAO_0000115 "Relates a gene to condition, such that a mutation in this gene in a germ cell provides a new function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T02:55:51Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "is causal gain of function germline mutation of in" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0004010 . obo:RO_0004012 obo:IAO_0000115 "Relates a gene to condition, such that a mutation in this gene in a germ cell impairs the function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T02:56:06Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "is causal loss of function germline mutation of in" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0004010 . obo:RO_0004013 obo:IAO_0000115 "Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T02:56:40Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "is causal germline mutation in" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0004010 . obo:RO_0004014 obo:IAO_0000115 "Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition but that cannot be passed on to offspring[modified from orphanet]." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T02:57:07Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "is causal somatic mutation in" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0004010 . obo:RO_0004015 obo:IAO_0000115 "Relates a gene to condition, such that a mutation in this gene predisposes to the development of a condition and that is necessary but not sufficient to develop the condition[modified from orphanet]." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T02:57:43Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "is causal susceptibility factor for" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0004010 . obo:RO_0004016 obo:IAO_0000115 "Relates a gene to condition, such that a mutation in this gene partially contributes to the presentation of this condition[modified from orphanet]." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T02:58:43Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "is causal germline mutation partially giving rise to" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0004010 . obo:RO_0004017 oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T03:20:01Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "realizable has basis in" ; rdfs:subPropertyOf obo:RO_0002410 ; owl:inverseOf obo:RO_0004018 . obo:RO_0004018 oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T03:20:29Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "is basis for realizable" ; rdfs:subPropertyOf obo:RO_0002410 . obo:RO_0004019 oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T03:26:47Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:domain obo:OGMS_0000031 ; rdfs:label "disease has basis in" ; rdfs:subPropertyOf obo:RO_0004017, obo:RO_0004023 . obo:RO_0004020 obo:IAO_0000115 "A relation that holds between the disease and a material entity where the physical basis of the disease is a disorder of that material entity that affects its function." ; obo:IAO_0000589 "disease has basis in dysfunction of (disease to anatomical structure)" ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T03:29:32Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "disease has basis in dysfunction of" ; rdfs:range obo:CARO_0000006 ; rdfs:subPropertyOf obo:RO_0004019 . obo:RO_0004021 obo:IAO_0000115 "A relation that holds between the disease and a process where the physical basis of the disease disrupts execution of a key biological process." ; obo:IAO_0000589 "disease has basis in disruption of (disease to process)" ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T03:37:52Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "disease has basis in disruption of" ; rdfs:range obo:BFO_0000015 ; rdfs:subPropertyOf obo:RO_0004019 . obo:RO_0004022 obo:IAO_0000115 "A relation that holds between the disease and a feature (a phenotype or other disease) where the physical basis of the disease is the feature." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T03:46:07Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:domain obo:OGMS_0000031 ; rdfs:label "disease has basis in feature" ; rdfs:range [ a owl:Class ; owl:unionOf (obo:OGMS_0000031 obo:UPHENO_0001001 ) ] ; rdfs:subPropertyOf obo:RO_0002200, obo:RO_0004019 . obo:RO_0004023 obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all of which have a disease as the subject." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T03:50:54Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:domain obo:OGMS_0000031 ; rdfs:label "causal relationship with disease as subject" ; rdfs:subPropertyOf obo:RO_0002410, obo:RO_0040035 . obo:RO_0004024 obo:IAO_0000115 "A relationship between a disease and a process where the disease process disrupts the execution of the process." ; obo:IAO_0000589 "disease causes disruption of (disease to process)" ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T03:51:09Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:domain obo:OGMS_0000031 ; rdfs:label "disease causes disruption of" ; rdfs:range obo:BFO_0000015 ; rdfs:subPropertyOf obo:RO_0004023 ; owl:propertyChainAxiom (obo:RO_0004024 obo:BFO_0000050 ), (obo:RO_0004025 obo:RO_0002215 ) . obo:RO_0004025 obo:IAO_0000589 "disease causes dysfunction of (disease to anatomical entity)" ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T03:58:20Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:domain obo:OGMS_0000031 ; rdfs:label "disease causes dysfunction of" ; rdfs:range obo:CARO_0000006 ; rdfs:subPropertyOf obo:RO_0004023 ; owl:propertyChainAxiom (obo:RO_0004025 obo:BFO_0000050 ) . obo:RO_0004026 obo:IAO_0000115 "A relationship between a disease and an anatomical entity where the disease has one or more features that are located in that entity." ; obo:IAO_0000116 "TODO: complete range axiom once more of CARO has been mireoted in to this ontology" ; obo:IAO_0000232 "This relation is intentionally very general, and covers isolated diseases, where the disease is realized as a process occurring in the location, and syndromic diseases, where one or more of the features may be present in that location. Thus any given disease can have multiple locations in the sense defined here." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-11-05T04:06:02Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:domain obo:OGMS_0000031 ; rdfs:label "disease has location" ; rdfs:range obo:BFO_0000004, [ a owl:Class ; owl:unionOf (obo:CARO_0000006 obo:CARO_0000007 ) ] ; rdfs:subPropertyOf obo:RO_0040035 . obo:RO_0004027 obo:IAO_0000115 "A relationship between a disease and an anatomical entity where the disease is triggered by an inflammatory response to stimuli occurring in the anatomical entity" ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-12-26T19:37:31Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:domain obo:OGMS_0000031 ; rdfs:label "disease has inflammation site" ; rdfs:range obo:BFO_0000004, [ a owl:Class ; owl:unionOf (obo:CARO_0000006 obo:CARO_0000007 ) ] ; rdfs:subPropertyOf obo:RO_0004026 . obo:RO_0004028 obo:IAO_0000115 "A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-12-26T19:45:49Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000017 ; rdfs:label "realized in response to stimulus" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0002410 ; owl:propertyChainAxiom (obo:RO_0009501 obo:RO_0002233 ) . obo:RO_0004029 obo:IAO_0000115 "A relationship between a disease and some feature of that disease, where the feature is either a phenotype or an isolated disease." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-12-26T19:50:53Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:domain obo:OGMS_0000031 ; rdfs:label "disease has feature" ; rdfs:range [ a owl:Class ; owl:unionOf (obo:OGMS_0000031 obo:UPHENO_0001001 ) ] ; rdfs:subPropertyOf obo:RO_0040035 . obo:RO_0004030 obo:IAO_0000115 "A relationship between a disease and an anatomical structure where the material basis of the disease is some pathological change in the structure." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2017-12-26T19:58:44Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "disease arises from structure" ; rdfs:range obo:CARO_0000003 ; rdfs:subPropertyOf obo:RO_0004019 . obo:RO_0004031 obo:IAO_0000115 "Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2018-01-25T23:20:13Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "enables subfunction" ; rdfs:subPropertyOf obo:RO_0002328 ; owl:propertyChainAxiom (obo:RO_0002327 obo:BFO_0000051 ) . obo:RO_0004032 obo:RO_0004049 obo:RO_0002264 ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2018-01-26T23:49:30Z"^^xsd:dateTime ; oboInOwl:inSubset obo:valid_for_go_gp2term ; a owl:ObjectProperty ; rdfs:label "acts upstream of or within, positive effect" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002264 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0004047 ) . obo:RO_0004033 obo:RO_0004050 obo:RO_0002264 ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2018-01-26T23:49:51Z"^^xsd:dateTime ; oboInOwl:inSubset obo:valid_for_go_gp2term ; a owl:ObjectProperty ; rdfs:label "acts upstream of or within, negative effect" ; rdfs:subPropertyOf obo:RO_0002264 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0004046 ) . obo:RO_0004034 obo:IAO_0000115 "c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive" ; obo:RO_0004049 obo:RO_0002263 ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2018-01-26T23:53:14Z"^^xsd:dateTime ; oboInOwl:inSubset obo:valid_for_go_gp2term ; a owl:ObjectProperty ; rdfs:label "acts upstream of, positive effect" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002263, obo:RO_0004032 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002304 ) . obo:RO_0004035 obo:IAO_0000115 "c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative" ; obo:RO_0004050 obo:RO_0002263 ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2018-01-26T23:53:22Z"^^xsd:dateTime ; oboInOwl:inSubset obo:valid_for_go_gp2term ; a owl:ObjectProperty ; rdfs:label "acts upstream of, negative effect" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002263, obo:RO_0004033 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002305 ) . obo:RO_0004046 obo:RO_0004050 obo:RO_0002418 ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2018-03-13T23:55:05Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "causally upstream of or within, negative effect" ; rdfs:subPropertyOf obo:RO_0002418 . obo:RO_0004047 obo:RO_0004049 obo:RO_0002418 ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2018-03-13T23:55:19Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "causally upstream of or within, positive effect" ; rdfs:subPropertyOf obo:RO_0002418 . obo:RO_0004048 obo:IAO_0000115 "Used to annotate object properties representing a causal relationship where the value indicates a direction. Should be \"+\", \"-\" or \"0\"" ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2018-03-13T23:59:29Z"^^xsd:dateTime ; a owl:AnnotationProperty ; rdfs:label "is directional form of" ; rdfs:subPropertyOf obo:RO_0002422 . obo:RO_0004049 oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2018-03-14T00:03:16Z"^^xsd:dateTime ; a owl:AnnotationProperty ; rdfs:label "is positive form of" ; rdfs:subPropertyOf obo:RO_0004048 . obo:RO_0004050 oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2018-03-14T00:03:24Z"^^xsd:dateTime ; a owl:AnnotationProperty ; rdfs:label "is negative form of" ; rdfs:subPropertyOf obo:RO_0004048 . obo:RO_0008501 obo:IAO_0000115 "An interaction relationship wherein a plant or algae is living on the outside surface of another plant." ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Epiphyte" ; a owl:ObjectProperty ; rdfs:label "epiphyte of" ; rdfs:subPropertyOf obo:RO_0002440 ; owl:inverseOf obo:RO_0008502 . obo:RO_0008502 obo:IAO_0000115 "inverse of epiphyte of" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "has epiphyte" ; rdfs:subPropertyOf obo:RO_0002440 . obo:RO_0008503 obo:IAO_0000115 "A sub-relation of parasite of in which a parasite steals resources from another organism, usually food or nest material" ; obo:IAO_0000119 "https://en.wikipedia.org/wiki/Kleptoparasitism" ; a owl:ObjectProperty ; rdfs:label "kleptoparasite of" ; rdfs:subPropertyOf obo:RO_0002444 ; owl:inverseOf obo:RO_0008504 . obo:RO_0008504 obo:IAO_0000115 "inverse of kleptoparasite of" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "kleptoparasitized by" ; rdfs:subPropertyOf obo:RO_0002445 . obo:RO_0008505 obo:IAO_0000115 "An interaction relationship wherein one organism creates a structure or environment that is lived in by another organism." ; a owl:ObjectProperty ; rdfs:domain obo:CARO_0001010 ; rdfs:label "creates habitat for" ; rdfs:range obo:CARO_0001010 ; rdfs:subPropertyOf obo:RO_0002321 . obo:RO_0008506 obo:IAO_0000115 "An interaction relationship describing organisms that often occur together at the same time and space or in the same environment." ; a owl:ObjectProperty, owl:SymmetricProperty ; rdfs:domain obo:CARO_0001010 ; rdfs:label "ecologically co-occurs with" ; rdfs:range obo:CARO_0001010 ; rdfs:subPropertyOf obo:RO_0002321 . obo:RO_0008507 obo:IAO_0000115 "An interaction relationship in which organism a lays eggs on the outside surface of organism b. Organism b is neither helped nor harmed in the process of egg laying or incubation." ; a owl:ObjectProperty ; rdfs:label "lays eggs on" ; rdfs:subPropertyOf obo:RO_0002618 ; owl:inverseOf obo:RO_0008508 . obo:RO_0008508 obo:IAO_0000115 "inverse of lays eggs on" ; a owl:ObjectProperty ; rdfs:label "has eggs laid on by" ; rdfs:subPropertyOf obo:RO_0002619 . obo:RO_0009001 obo:IAO_0000112 "muffin 'has substance added' some 'baking soda'"@en ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "\"has substance added\" is a relation existing between a (physical) entity and a substance in which the entity has had the substance added to it at some point in time."@en ; obo:IAO_0000116 "The relation X 'has substance added' some Y doesn't imply that X still has Y in any detectable fashion subsequent to the addition. Water in dehydrated food or ice cubes are examples, as is food that undergoes chemical transformation. This definition should encompass recipe ingredients."@en ; obo:IAO_0000117 "Damion Dooley" ; a owl:IrreflexiveProperty, owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "has substance added"@en ; rdfs:range obo:BFO_0000040 . obo:RO_0009002 obo:IAO_0000112 "'egg white' 'has substance removed' some 'egg yolk'"@en ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "\"has substance removed\" is a relation existing between two physical entities in which the first entity has had the second entity (a substance) removed from it at some point in time."@en ; obo:IAO_0000117 "Damion Dooley"@en ; a owl:IrreflexiveProperty, owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "has substance removed"@en ; rdfs:range obo:BFO_0000040 . obo:RO_0009003 obo:IAO_0000112 "sardines 'immersed in' some 'oil and mustard'"@en ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "\"immersed in\" is a relation between a (physical) entity and a fluid substance in which the entity is wholely or substantially surrounded by the substance."@en ; obo:IAO_0000117 "Damion Dooley" ; a owl:IrreflexiveProperty, owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "immersed in"@en ; rdfs:range obo:BFO_0000040 . obo:RO_0009004 obo:IAO_0000112 "sardine has consumer some homo sapiens"@en ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "'has consumer' is a relation between a material entity and an organism in which the former can normally be digested or otherwise absorbed by the latter without immediate or persistent ill effect."@en ; obo:IAO_0000117 "Damion Dooley" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "has consumer"@en ; rdfs:range obo:CARO_0001010 . obo:RO_0009005 obo:IAO_0000112 "bread 'has primary substance added' some 'flour'"@en ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "'has primary substance added' indicates that an entity has had the given substance added to it in a proportion greater than any other added substance."@en ; obo:IAO_0000117 "Damion Dooley" ; a owl:IrreflexiveProperty, owl:ObjectProperty ; rdfs:label "has primary substance added"@en ; rdfs:subPropertyOf obo:RO_0009001 . obo:RO_0009501 obo:IAO_0000112 "A drought sensitivity trait that inheres in a whole plant is realized in a systemic response process in response to exposure to drought conditions.", "An inflammatory disease that is realized in response to an inflammatory process occurring in the gut (which is itself the realization of a process realized in response to harmful stimuli in the mucosal lining of th gut)", "Environmental polymorphism in butterflies: These butterflies have a 'responsivity to day length trait' that is realized in response to the duration of the day, and is realized in developmental processes that lead to increased or decreased pigmentation in the adult morph." ; obo:IAO_0000115 "r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r." ; terms:contributor "Austin Meier", "Chris Mungall", "David Osumi-Sutherland", "Marie Angelique Laporte" ; oboInOwl:hasExactSynonym "triggered by process" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000017 ; rdfs:label "realized in response to"@en ; rdfs:range obo:BFO_0000015 ; rdfs:seeAlso "https://docs.google.com/document/d/1KWhZxVBhIPkV6_daHta0h6UyHbjY2eIrnON1WIRGgdY/edit"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002410 ; owl:propertyChainAxiom (obo:BFO_0000054 obo:RO_0002404 ) . obo:RO_0010001 obo:IAO_0000112 "Genetic information generically depend on molecules of DNA.", "The novel *War and Peace* generically depends on this copy of the novel.", "The pattern shared by chess boards generically depends on any chess board.", "The score of a symphony g-depends on a copy of the score.", "This pdf file generically depends on this server." ; obo:IAO_0000115 "A generically dependent continuant *b* generically depends on an independent continuant *c* at time *t* means: there inheres in *c* a specifically deendent continuant which concretizes *b* at *t*." ; obo:IAO_0000119 "[072-ISO]" ; oboInOwl:hasExactSynonym "g-depends on" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000031 ; rdfs:label "generically depends on" ; rdfs:range obo:BFO_0000004 ; owl:inverseOf obo:RO_0010002 ; owl:propertyChainAxiom (obo:RO_0000052 obo:RO_0000058 ) . obo:RO_0010002 obo:IAO_0000112 "Molecules of DNA are carriers of genetic information.", "This copy of *War and Peace* is carrier of the novel written by Tolstoy.", "This hard drive is carrier of these data items." ; obo:IAO_0000115 "*b* is carrier of *c* at time *t* if and only if *c* *g-depends on* *b* at *t*" ; obo:IAO_0000119 "[072-ISO]" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "is carrier of"@en ; rdfs:range obo:BFO_0000031 ; owl:propertyChainAxiom (obo:RO_0000059 obo:RO_0000053 ) . obo:RO_0011002 obo:IAO_0000115 "The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B." ; obo:IAO_0000117 "Vasundra Touré" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "regulates activity of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0002566 . obo:RO_0011003 obo:IAO_0000115 "The entity A has an activity that regulates the quantity or abundance or concentration of the entity B." ; obo:IAO_0000117 "Vasundra Touré" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "regulates quantity of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0002566 . obo:RO_0011004 obo:IAO_0000115 "The entity A is not immediately upstream of the entity B but A has an activity that regulates an activity performed by B." ; obo:IAO_0000117 "Vasundra Touré" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "indirectly regulates activity of"@en ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0011002 . obo:RO_0011007 obo:IAO_0000115 """The entity A has an activity that down-regulates by repression the quantity of B. The down-regulation is due to A having an effect on an intermediate entity (typically a DNA or mRNA element) which can produce B. For example, protein A (transcription factor) indirectly decreases by repression the quantity of protein B (gene product) if and only if A negatively regulates the process of transcription or translation of a nucleic acid element that produces B.""" ; obo:IAO_0000117 "Vasundra Touré" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "decreases by repression quantity of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0011023 . obo:RO_0011008 obo:IAO_0000115 """The entity A has an activity that up-regulates by expression the quantity of B. The up-regulation is due to A having an effect on an intermediate entity (typically a DNA or mRNA element) which can produce B. For example, protein A (transcription factor) indirectly increases by expression the quantity of protein B (gene product) if and only if A positively regulates the process of transcription or translation of a nucleic acid element that produces B.""" ; obo:IAO_0000117 "Vasundra Touré" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "increases by expression quantity of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0011024 . obo:RO_0011009 obo:IAO_0000115 "The entity A has an activity that directly positively regulates the quantity of B." ; obo:IAO_0000117 "Vasundra Touré" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "directly positively regulates quantity of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0011021 . obo:RO_0011010 obo:IAO_0000115 "The entity A has an activity that directly negatively regulates the quantity of B." ; obo:IAO_0000117 "Vasundra Touré" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "directly negatively regulates quantity of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0011021 . obo:RO_0011013 obo:IAO_0000115 "The entity A is not immediately upstream of the entity B and has an activity that up-regulates an activity performed by B." ; obo:IAO_0000117 "Vasundra Touré" ; obo:IAO_0000118 "indirectly activates" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "indirectly positively regulates activity of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0011004 . obo:RO_0011014 obo:IAO_0000112 "AKT1 destabilizes quantity of FOXO (interaction from Signor database: SIGNOR-252844)" ; obo:IAO_0000115 "An entity A directly interacts with B and A has an activity that decreases the amount of an entity B by degradating it." ; obo:IAO_0000117 "Vasundra Touré" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "destabilizes quantity of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0011010 . obo:RO_0011015 obo:IAO_0000112 "AKT1 stabilizes quantity of XIAP (interaction from Signor database: SIGNOR-119488)" ; obo:IAO_0000115 "An entity A physically interacts with B and A has an activity that increases the amount of an entity B by stabilizing it." ; obo:IAO_0000117 "Vasundra Touré" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "stabilizes quantity of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0011009 . obo:RO_0011016 obo:IAO_0000115 "The entity A is not immediately upstream of the entity B and has an activity that down-regulates an activity performed by B." ; obo:IAO_0000117 "Vasundra Touré" ; obo:IAO_0000118 "indirectly inhibits" ; a owl:ObjectProperty ; rdfs:label "indirectly negatively regulates activity of" ; rdfs:subPropertyOf obo:RO_0011004 . obo:RO_0011021 obo:IAO_0000115 "The entity A, immediately upstream of B, has an activity that directly regulates the quantity of B." ; obo:IAO_0000117 "Vasundra Touré" ; a owl:ObjectProperty ; rdfs:label "directly regulates quantity of" ; rdfs:subPropertyOf obo:RO_0011003 . obo:RO_0011022 obo:IAO_0000115 "The entity A is not immediately upstream of the entity B, but A has an activity that regulates the quantity or abundance or concentration of B." ; obo:IAO_0000117 "Vasundra Touré" ; a owl:ObjectProperty ; rdfs:label "indirectly regulates quantity of" ; rdfs:subPropertyOf obo:RO_0011003 . obo:RO_0011023 obo:IAO_0000115 "The entity A does not physically interact with the entity B, and A has an activity that down-regulates the quantity or abundance or concentration of B." ; obo:IAO_0000117 "Vasundra Touré" ; a owl:ObjectProperty ; rdfs:label "indirectly negatively regulates quantity of" ; rdfs:subPropertyOf obo:RO_0011022 . obo:RO_0011024 obo:IAO_0000115 "The entity A does not physically interact with the entity B, and A has an activity that up-regulates the quantity or abundance or concentration of B." ; obo:IAO_0000117 "Vasundra Touré" ; a owl:ObjectProperty ; rdfs:label "indirectly positively regulates quantity of" ; rdfs:subPropertyOf obo:RO_0011022 . obo:RO_0012000 obo:IAO_0000115 "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant"^^xsd:string ; oboInOwl:created_by "pg"^^xsd:string ; oboInOwl:creation_date "2020-04-22T20:27:26Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "has small molecule regulator"@en ; rdfs:subPropertyOf obo:RO_0000057 . obo:RO_0012001 obo:IAO_0000115 "a relation between a process and a continuant, in which the process is activated by the small molecule continuant"^^xsd:string ; oboInOwl:created_by "pg"^^xsd:string ; oboInOwl:creation_date "2020-04-22T20:28:37Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "has small molecule activator"@en ; rdfs:subPropertyOf obo:RO_0012000 . obo:RO_0012002 obo:IAO_0000115 "a relation between a process and a continuant, in which the process is inhibited by the small molecule continuant"^^xsd:string ; oboInOwl:created_by "pg"^^xsd:string ; oboInOwl:creation_date "2020-04-22T20:28:54Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "has small molecule inhibitor"@en ; rdfs:subPropertyOf obo:RO_0012000 . obo:RO_0012003 obo:IAO_0000115 "p acts on population of c iff c' is a collection, has members of type c, and p has participant c"^^xsd:string ; oboInOwl:created_by "pg"^^xsd:string ; oboInOwl:creation_date "2020-06-08T17:21:33Z"^^xsd:dateTime ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "acts on population of"@en ; rdfs:subPropertyOf obo:RO_0000057 . obo:RO_0012004 obo:IAO_0000115 "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process"^^xsd:string ; oboInOwl:created_by "pg"^^xsd:string ; oboInOwl:creation_date "2020-06-24T13:15:17Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "is small molecule regulator"@en ; rdfs:subPropertyOf obo:RO_0000057 . obo:RO_0012005 obo:IAO_0000115 "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process"^^xsd:string ; oboInOwl:created_by "pg"^^xsd:string ; oboInOwl:creation_date "2020-06-24T13:15:26Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "is small molecule activator"@en ; rdfs:subPropertyOf obo:RO_0012004 . obo:RO_0012006 obo:IAO_0000115 "a relation between a continuant and a process, in which the continuant is a small molecule that inhibits the process"^^xsd:string ; oboInOwl:created_by "pg"^^xsd:string ; oboInOwl:creation_date "2020-06-24T13:15:35Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "is small molecule inhibitor"@en ; rdfs:subPropertyOf obo:RO_0012004 . obo:RO_0012007 obo:IAO_0000115 "The relationship that links anatomical entities with a process that results in the adhesion of two or more entities via the non-covalent interaction of molecules expressed in, located in, and/or adjacent to, those entities."^^xsd:string ; oboInOwl:created_by "pg"^^xsd:string ; oboInOwl:creation_date "2020-08-27T08:13:59Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "results in adhesion of"@en ; rdfs:subPropertyOf obo:RO_0040036 . obo:RO_0012008 oboInOwl:created_by "pg"^^xsd:string ; oboInOwl:creation_date "2021-02-26T07:28:29Z"^^xsd:dateTime ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "results in fusion of"@en ; rdfs:subPropertyOf obo:RO_0002592 . obo:RO_0013001 obo:IAO_0000115 "A relationship between a neuron and a region, where the neuron has a functionally relevant number of input and/or output synapses in that region." ; oboInOwl:created_by ; oboInOwl:creation_date "2020-07-17T09:26:52Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "has synaptic input or output in" ; a owl:ObjectProperty ; rdfs:label "has synaptic IO in"@en ; rdfs:subPropertyOf obo:RO_0002130 ; owl:propertyChainAxiom (obo:RO_0013001 obo:BFO_0000050 ) . obo:RO_0013002 obo:IAO_0000115 "A relationship between a neuron and a region, where the neuron has a functionally relevant number of input synapses in that region." ; oboInOwl:created_by ; oboInOwl:creation_date "2020-07-17T09:42:23Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "receives synaptic input in"@en ; rdfs:subPropertyOf obo:RO_0002110, obo:RO_0013001 ; owl:propertyChainAxiom (obo:RO_0013002 obo:BFO_0000050 ) . obo:RO_0013003 obo:IAO_0000115 "A relationship between a neuron and a region, where the neuron has a functionally relevant number of output synapses in that region." ; oboInOwl:created_by ; oboInOwl:creation_date "2020-07-17T09:45:06Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "sends synaptic output to"@en ; rdfs:subPropertyOf obo:RO_0002113, obo:RO_0013001 ; owl:propertyChainAxiom (obo:RO_0013003 obo:BFO_0000050 ) . obo:RO_0013004 obo:IAO_0000115 "A relationship between a neuron and a region, where the neuron has a functionally relevant number of input and/or output synapses distributed throughout that region (rather than confined to a subregion)." ; oboInOwl:created_by ; oboInOwl:creation_date "2020-07-17T09:52:19Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "has synaptic IO throughout"@en ; rdfs:subPropertyOf obo:RO_0013001 . obo:RO_0013005 obo:IAO_0000115 "A relationship between a neuron and a region, where the neuron has a functionally relevant number of input synapses distributed throughout that region (rather than confined to a subregion)." ; oboInOwl:created_by ; oboInOwl:creation_date "2020-07-17T09:55:36Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "receives synaptic input throughout"@en ; rdfs:subPropertyOf obo:RO_0013002, obo:RO_0013004 . obo:RO_0013006 obo:IAO_0000115 "A relationship between a neuron and a region, where the neuron has a functionally relevant number output synapses distributed throughout that region (rather than confined to a subregion)." ; oboInOwl:created_by ; oboInOwl:creation_date "2020-07-17T09:57:27Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "sends synaptic output throughout"@en ; rdfs:subPropertyOf obo:RO_0013003, obo:RO_0013004 . obo:RO_0013007 obo:IAO_0000115 "Relation between a sensory neuron and some structure in which it receives sensory input via a sensory dendrite." ; oboInOwl:created_by ; oboInOwl:creation_date "2020-07-20T12:10:09Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "has sensory dendrite location", "has sensory terminal in", "has sensory terminal location" ; a owl:ObjectProperty ; rdfs:domain obo:CL_0000101 ; rdfs:label "has sensory dendrite in"@en ; rdfs:subPropertyOf obo:RO_0002360 ; owl:propertyChainAxiom (obo:RO_0013007 obo:BFO_0000050 ) . obo:RO_0014001 obo:IAO_0000115 "A relationship between a disease and an infectious agent where the material basis of the disease is an infection with some infectious agent." ; oboInOwl:created_by ; a owl:ObjectProperty ; rdfs:label "disease has infectious agent" ; rdfs:subPropertyOf obo:RO_0004019 . obo:RO_0040035 obo:IAO_0000115 "This relation groups relations between diseases and any other kind of entity." ; obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, in which the subject or object is a disease." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2018-09-26T00:00:32Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "disease relationship" . obo:RO_0040036 obo:IAO_0000115 "p has anatomical participant c iff p has participant c, and c is an anatomical entity" ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2018-09-26T01:08:58Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "has anatomical participant" ; rdfs:range [ a owl:Class ; owl:unionOf (obo:CARO_0000006 obo:CARO_0000007 ) ] ; rdfs:subPropertyOf obo:RO_0000057 . obo:RO_0040042 obo:IAO_0000112 "part-of is homeomorphic for independent continuants." ; obo:IAO_0000115 "R is homemorphic for C iff (1) there exists some x,y such that x R y, and x and y instantiate C and (2) for all x, if x is an instance of C, and there exists some y some such that x R y, then it follows that y is an instance of C." ; oboInOwl:created_by "cjm"^^xsd:string ; oboInOwl:creation_date "2018-10-21T19:46:34Z"^^xsd:dateTime ; a owl:AnnotationProperty ; rdfs:comment "R homeomorphic-for C expands to: C SubClassOf R only C. Additionally, for any class D that is disjoint with C, we can also expand to C DisjointWith R some D, D DisjointWith R some C." ; rdfs:label "is homeomorphic for" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002422 . obo:RO_HOM0000000 obo:IAO_0000116 "TODO: Add homeomorphy axiom" ; obo:RO_0040042 obo:BFO_0000002, obo:BFO_0000003 . obo:RO_HOM0000001 rdfs:subPropertyOf obo:RO_0002158 . obo:RO_HOM0000003 rdfs:subPropertyOf obo:RO_0002320 . dc:description "The OBO Relations Ontology (RO) is a collection of OWL relations (ObjectProperties) intended for use across a wide variety of biological ontologies."@en ; dc:title "OBO Relations Ontology"@en ; terms:license ; a owl:Ontology ; owl:imports , , , , , , , , , , , ; owl:versionIRI ; foaf:homepage " https://github.com/oborel/obo-relations/"^^xsd:anyURI . :x a swrl:Variable . :y a swrl:Variable . :z a swrl:Variable . subsets:ro-eco a owl:AnnotationProperty ; rdfs:label "eco subset" ; rdfs:seeAlso ; rdfs:subPropertyOf oboInOwl:SubsetProperty . obo:valid_for_go_annotation_extension oboInOwl:created_by "pg"^^xsd:string ; oboInOwl:creation_date "2020-09-22T11:05:29Z"^^xsd:dateTime ; a owl:AnnotationProperty ; rdfs:label "valid_for_go_annotation_extension"@en ; rdfs:seeAlso ; rdfs:subPropertyOf oboInOwl:SubsetProperty . obo:valid_for_go_gp2term oboInOwl:created_by "pg"^^xsd:string ; oboInOwl:creation_date "2020-09-22T11:05:18Z"^^xsd:dateTime ; a owl:AnnotationProperty ; rdfs:label "valid_for_go_gp2term"@en ; rdfs:seeAlso ; rdfs:subPropertyOf oboInOwl:SubsetProperty . obo:valid_for_go_ontology oboInOwl:created_by "pg"^^xsd:string ; oboInOwl:creation_date "2020-09-22T11:04:12Z"^^xsd:dateTime ; a owl:AnnotationProperty ; rdfs:label "valid_for_go_ontology"@en ; rdfs:seeAlso ; rdfs:subPropertyOf oboInOwl:SubsetProperty . obo:valid_for_gocam oboInOwl:created_by "pg"^^xsd:string ; oboInOwl:creation_date "2020-09-22T11:05:45Z"^^xsd:dateTime ; a owl:AnnotationProperty ; rdfs:label "valid_for_gocam"@en ; rdfs:seeAlso ; rdfs:subPropertyOf oboInOwl:SubsetProperty . dc:description a owl:AnnotationProperty . dc:license a owl:AnnotationProperty . terms:contributor a owl:AnnotationProperty . terms:creator a owl:AnnotationProperty . terms:description a owl:AnnotationProperty . terms:license a owl:AnnotationProperty . terms:source a owl:AnnotationProperty . terms:title a owl:AnnotationProperty . cito:citesAsAuthority a owl:AnnotationProperty . swrla:isRuleEnabled a owl:AnnotationProperty . oboInOwl:SubsetProperty a owl:AnnotationProperty ; rdfs:label "subset_property"^^xsd:string . oboInOwl:created_by a owl:AnnotationProperty . oboInOwl:creation_date a owl:AnnotationProperty . oboInOwl:inSubset a owl:AnnotationProperty ; rdfs:label "in_subset"^^xsd:string . rdfs:isDefinedBy obo:IAO_0000589 "is defined by" . rdfs:seeAlso a owl:AnnotationProperty . owl:topObjectProperty a owl:ObjectProperty . skos:closeMatch a owl:AnnotationProperty . foaf:image a owl:Class . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . [] obo:RO_0002582 true ; a owl:Axiom ; owl:annotatedProperty owl:propertyChainAxiom ; owl:annotatedSource obo:RO_0002177 ; owl:annotatedTarget (obo:RO_0002371 obo:BFO_0000050 ) . [] obo:RO_0002582 true ; a owl:Axiom ; owl:annotatedProperty owl:propertyChainAxiom ; owl:annotatedSource obo:RO_0002216 ; owl:annotatedTarget (obo:RO_0002215 obo:BFO_0000050 ) . [] a owl:Axiom ; rdfs:seeAlso ; owl:annotatedProperty obo:IAO_0000112 ; owl:annotatedSource obo:RO_0002220 ; owl:annotatedTarget "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." . [] obo:RO_0002582 true ; a owl:Axiom ; owl:annotatedProperty owl:propertyChainAxiom ; owl:annotatedSource obo:RO_0002314 ; owl:annotatedTarget (obo:RO_0000052 obo:BFO_0000050 ) . [] obo:RO_0002581 true ; a owl:Axiom ; owl:annotatedProperty owl:propertyChainAxiom ; owl:annotatedSource obo:RO_0002329 ; owl:annotatedTarget (obo:BFO_0000050 obo:RO_0002215 ) . [] a owl:Axiom ; rdfs:comment "We need to import uberon muscle to create a stricter domain constraint" ; owl:annotatedProperty rdfs:domain ; owl:annotatedSource obo:RO_0002372 ; owl:annotatedTarget obo:CARO_0000003 . [] obo:IAO_0000116 "We need to import uberon muscle into RO to use as a stricter domain constraint" ; a owl:Axiom ; owl:annotatedProperty rdfs:domain ; owl:annotatedSource obo:RO_0002373 ; owl:annotatedTarget obo:CARO_0000003 . [] obo:RO_0002581 true ; a owl:Axiom ; owl:annotatedProperty owl:propertyChainAxiom ; owl:annotatedSource obo:RO_0002432 ; owl:annotatedTarget (obo:RO_0002327 obo:BFO_0000066 ) . [] oboInOwl:hasDbXref "GOC:cjm"^^xsd:string, "GOC:dos"^^xsd:string ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0002432 ; owl:annotatedTarget "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." . [] obo:RO_0002581 true ; a owl:Axiom ; owl:annotatedProperty owl:propertyChainAxiom ; owl:annotatedSource obo:RO_0002479 ; owl:annotatedTarget (obo:BFO_0000051 obo:BFO_0000066 ) . [] oboInOwl:hasDbXref "GOC:dos"^^xsd:string ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:RO_0002022 ; owl:annotatedTarget "Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2." . [] oboInOwl:hasDbXref "GOC:dos"^^xsd:string ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0002023 ; owl:annotatedTarget "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." . [] oboInOwl:hasDbXref "GOC:dos"^^xsd:string ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0002024 ; owl:annotatedTarget "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." . [] obo:RO_0002582 true ; a owl:Axiom ; owl:annotatedProperty owl:propertyChainAxiom ; owl:annotatedSource obo:RO_0002509 ; owl:annotatedTarget (obo:RO_0002507 obo:BFO_0000050 ) . [] oboInOwl:hasDbXref "GOC:dos"^^xsd:string ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0002025 ; owl:annotatedTarget "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity." . [] oboInOwl:hasDbXref "GOC:dos"^^xsd:string ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0002026 ; owl:annotatedTarget """A relationship that holds between two images, A and B, where: A depicts X; B depicts Y; X and Y are both of type T' C is a 2 layer image consiting of layers A and B; A and B are aligned in C according to a shared co-ordinate framework so that common features of X and Y are co-incident with each other. Note: A and B may be 2D or 3D. Examples include: the relationship between two channels collected simultaneously from a confocal microscope; the relationship between an image dpeicting X and a painted annotation layer that delineates regions of X; the relationship between the tracing of a neuron on an EM stack and the co-ordinate space of the stack; the relationship between two separately collected images that have been brought into register via some image registration software.""" . [] obo:IAO_0000116 "This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional." ; a owl:Axiom ; owl:annotatedProperty rdfs:range ; owl:annotatedSource obo:RO_0002551 ; owl:annotatedTarget obo:CARO_0000006 . [] a owl:Axiom ; rdfs:comment "Usage of the term 'treats' applies when we believe there to be a an inhibitory relationship" ; owl:annotatedProperty obo:IAO_0000118 ; owl:annotatedSource obo:RO_0002599 ; owl:annotatedTarget "treats" . [] oboInOwl:hasDbXref "GOC:cjm"^^xsd:string, "GOC:dph"^^xsd:string, "GOC:kva", "GOC:pt" ; a owl:Axiom ; rdfs:comment "PMID:27812932" ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0004008 ; owl:annotatedTarget "p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c." . [] oboInOwl:hasDbXref "GOC:cjm"^^xsd:string, "GOC:dph"^^xsd:string, "GOC:kva", "GOC:pt" ; a owl:Axiom ; rdfs:comment "PMID:27812932" ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0004009 ; owl:annotatedTarget "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c." . [] oboInOwl:hasDbXref "RO:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:RO_0009501 ; owl:annotatedTarget "triggered by process" . [] oboInOwl:hasDbXref "PMID:24138933", "Wikipedia:Infant_mortality" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0002029 ; owl:annotatedTarget "Then percentage of organisms in a population that die during some specified age range (age-specific mortality rate), minus the percentage that die in during the same age range in a wild-type population." . [] a owl:Axiom ; rdfs:comment "This is an experimental annotation" ; owl:annotatedProperty obo:IAO_0000589 ; owl:annotatedSource rdfs:isDefinedBy ; owl:annotatedTarget "is defined by" . [] a owl:Restriction ; rdfs:subClassOf [ a owl:Class ; owl:unionOf ([ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0002418 ; owl:someValuesFrom obo:BFO_0000015 ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0002418 ; owl:someValuesFrom obo:BFO_0000015 ] ] ] ) ] ; owl:onProperty obo:RO_0002566 ; owl:someValuesFrom obo:BFO_0000040 . [] a swrl:Imp ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002180 ] [ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate obo:BFO_0000015 ] [ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate obo:BFO_0000015 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002018 ] ) . [] swrla:isRuleEnabled true ; a swrl:Imp ; rdfs:comment "MF(X)-directly_regulates->MF(Y)-enabled_by->GP(Z) => MF(Y)-has_input->GP(Y) e.g. if 'protein kinase activity'(X) directly_regulates 'protein binding activity (Y)and this is enabled by GP(Z) then X has_input Z"^^xsd:string ; rdfs:label "infer input from direct reg"^^xsd:string ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 :z ; swrl:argument2 :y ; swrl:propertyPredicate obo:RO_0002327 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 :x ; swrl:argument2 :y ; swrl:propertyPredicate obo:RO_0002578 ] [ a swrl:ClassAtom ; swrl:argument1 :x ; swrl:classPredicate obo:GO_0003674 ] [ a swrl:ClassAtom ; swrl:argument1 :y ; swrl:classPredicate obo:GO_0003674 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 :x ; swrl:argument2 :z ; swrl:propertyPredicate obo:RO_0002233 ] ) . [] a swrl:Imp ; rdfs:comment """GP(X)-enables->MF(Y)-has_part->MF(Z) => GP(X) enables MF(Z), e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase coupled transporter activity' has_part 'ATPase activity' then GP(X) enables 'ATPase activity'""" ; rdfs:label "enabling an MF enables its parts" ; swrl:body ([ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate obo:GO_0003674 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002327 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:BFO_0000051 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002327 ] ) . [] swrla:isRuleEnabled true ; a swrl:Imp ; rdfs:comment "GP(X)-enables->MF(Y)-part_of->BP(Z) => GP(X) involved_in BP(Z) e.g. if X enables 'protein kinase activity' and Y 'part of' 'signal tranduction' then X involved in 'signal transduction'"^^xsd:string ; rdfs:label "involved in BP"^^xsd:string ; swrl:body ([ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate obo:GO_0008150 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:BFO_0000050 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002327 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002331 ] ) . [] a swrl:Imp ; rdfs:seeAlso ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002578 ] [ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate obo:GO_0016301 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002333 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002333 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002447 ] ) . [] a swrl:Imp ; rdfs:comment "This rule is dubious: added as a quick fix for expected inference in GO-CAM. The problem is most acute for transmembrane proteins, such as receptors or cell adhesion molecules, which have some subfunctions inside the cell (e.g. kinase activity) and some subfunctions outside (e.g. ligand binding). Correct annotation of where these functions occurs leads to incorrect inference about the location of the whole protein. This should probably be weakened to \"... -> overlaps\"" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002327 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:BFO_0000066 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:BFO_0000050 ] ) . [] a swrl:Imp ; rdfs:comment "If a molecular function (X) has a regulatory subfunction, then any gene product which is an input to that subfunction has an activity that directly_regulates X. Note: this is intended for cases where the regaultory subfunction is protein binding, so it could be tightened with an additional clause to specify this." ; rdfs:label "inferring direct reg edge from input to regulatory subfunction" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002352 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002333 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002013 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002578 ] ) . [] a swrl:Imp ; rdfs:label "inferring direct neg reg edge from input to regulatory subfunction" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002352 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002333 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002014 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002630 ] ) . [] a swrl:Imp ; rdfs:label "inferring direct positive reg edge from input to regulatory subfunction" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002352 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002333 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002015 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002629 ] ) . [] a swrl:Imp ; rdfs:label "effector input is compound function input" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002025 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002233 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002233 ] ) . [] a swrl:Imp ; rdfs:label "Input of effector is input of its parent MF" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002025 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002233 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002233 ] ) . [] a swrl:Imp ; rdfs:comment "if effector directly regulates X, its parent MF directly regulates X" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002578 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002025 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002578 ] ) . [] a swrl:Imp ; rdfs:comment "if effector directly positively regulates X, its parent MF directly positively regulates X" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002025 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002629 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002629 ] ) . [] a swrl:Imp ; rdfs:label "if effector directly negatively regulates X, its parent MF directly negatively regulates X" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002630 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002025 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002630 ] ) . [] a swrl:Imp ; rdfs:label "'causally downstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties)." ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002131 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002404 ] ) ; swrl:head ([ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate owl:Nothing ] [ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate owl:Nothing ] ) . [] a swrl:Imp ; rdfs:label "'causally upstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties)." ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002131 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002411 ] ) ; swrl:head ([ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate owl:Nothing ] [ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate owl:Nothing ] ) . [] a swrl:Imp ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002212 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002213 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002212 ] ) . [] a swrl:Imp ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002212 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002213 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002212 ] ) . [] obo:RO_0002582 true ; a owl:Axiom ; owl:annotatedProperty owl:propertyChainAxiom ; owl:annotatedSource obo:RO_0002131 ; owl:annotatedTarget (obo:BFO_0000051 obo:BFO_0000050 ) .